-- dump date 20140619_091511 -- class Genbank::misc_feature -- table misc_feature_note -- id note 741093000001 Initiator Replication protein; Region: Rep_3; pfam01051 741093000002 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 741093000003 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093000004 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093000005 catalytic residue [active] 741093000006 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 741093000007 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 741093000008 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 741093000009 Type IV secretion system proteins; Region: T4SS; pfam07996 741093000010 VirB8 protein; Region: VirB8; pfam04335 741093000011 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 741093000012 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 741093000013 VirB7 interaction site; other site 741093000014 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 741093000015 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 741093000016 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 741093000017 ATP binding site [chemical binding]; other site 741093000018 Walker A motif; other site 741093000019 hexamer interface [polypeptide binding]; other site 741093000020 Walker B motif; other site 741093000021 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 741093000022 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 741093000023 Walker A motif; other site 741093000024 ATP binding site [chemical binding]; other site 741093000025 Walker B motif; other site 741093000026 TrbM; Region: TrbM; pfam07424 741093000027 DNA topoisomerase III; Provisional; Region: PRK07726 741093000028 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 741093000029 active site 741093000030 putative interdomain interaction site [polypeptide binding]; other site 741093000031 putative metal-binding site [ion binding]; other site 741093000032 putative nucleotide binding site [chemical binding]; other site 741093000033 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 741093000034 DNA binding groove [nucleotide binding] 741093000035 domain I; other site 741093000036 phosphate binding site [ion binding]; other site 741093000037 domain II; other site 741093000038 domain III; other site 741093000039 nucleotide binding site [chemical binding]; other site 741093000040 catalytic site [active] 741093000041 domain IV; other site 741093000042 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 741093000043 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 741093000044 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 741093000045 SprT homologues; Region: SprT; cl01182 741093000046 SprT-like family; Region: SprT-like; pfam10263 741093000047 Staphylococcal nuclease homologues; Region: SNc; smart00318 741093000048 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 741093000049 Catalytic site; other site 741093000050 Haemolysin expression modulating protein; Region: HHA; cl11501 741093000051 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 741093000052 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 741093000053 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 741093000054 conjugal transfer protein TraL; Provisional; Region: PRK13886 741093000055 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 741093000056 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 741093000057 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741093000058 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 741093000059 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 741093000060 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 741093000061 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 741093000062 putative catalytic residues [active] 741093000063 putative nucleotide binding site [chemical binding]; other site 741093000064 putative aspartate binding site [chemical binding]; other site 741093000065 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 741093000066 dimer interface [polypeptide binding]; other site 741093000067 putative threonine allosteric regulatory site; other site 741093000068 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 741093000069 putative threonine allosteric regulatory site; other site 741093000070 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 741093000071 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 741093000072 homoserine kinase; Region: thrB; TIGR00191 741093000073 Protein of unknown function; Region: YhfT; pfam10797 741093000074 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 741093000075 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 741093000076 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 741093000077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093000078 catalytic residue [active] 741093000079 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 741093000080 hypothetical protein; Validated; Region: PRK02101 741093000081 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 741093000082 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 741093000083 transaldolase-like protein; Provisional; Region: PTZ00411 741093000084 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 741093000085 active site 741093000086 dimer interface [polypeptide binding]; other site 741093000087 catalytic residue [active] 741093000088 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 741093000089 MPT binding site; other site 741093000090 trimer interface [polypeptide binding]; other site 741093000091 hypothetical protein; Provisional; Region: PRK10659 741093000092 hypothetical protein; Provisional; Region: PRK10236 741093000093 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 741093000094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 741093000095 hypothetical protein; Provisional; Region: PRK10154 741093000096 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 741093000097 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 741093000098 nucleotide binding site [chemical binding]; other site 741093000099 NEF interaction site [polypeptide binding]; other site 741093000100 SBD interface [polypeptide binding]; other site 741093000101 chaperone protein DnaJ; Provisional; Region: PRK10767 741093000102 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 741093000103 HSP70 interaction site [polypeptide binding]; other site 741093000104 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 741093000105 substrate binding site [polypeptide binding]; other site 741093000106 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 741093000107 Zn binding sites [ion binding]; other site 741093000108 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 741093000109 dimer interface [polypeptide binding]; other site 741093000110 Hok/gef family; Region: HOK_GEF; pfam01848 741093000111 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 741093000112 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 741093000113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093000114 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 741093000115 putative dimerization interface [polypeptide binding]; other site 741093000116 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 741093000117 PapC N-terminal domain; Region: PapC_N; pfam13954 741093000118 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093000119 PapC C-terminal domain; Region: PapC_C; pfam13953 741093000120 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 741093000121 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093000122 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093000123 Fimbrial protein; Region: Fimbrial; cl01416 741093000124 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 741093000125 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 741093000126 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 741093000127 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 741093000128 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 741093000129 active site 741093000130 Riboflavin kinase; Region: Flavokinase; smart00904 741093000131 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 741093000132 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 741093000133 HIGH motif; other site 741093000134 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 741093000135 active site 741093000136 KMSKS motif; other site 741093000137 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 741093000138 tRNA binding surface [nucleotide binding]; other site 741093000139 anticodon binding site; other site 741093000140 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 741093000141 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 741093000142 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 741093000143 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741093000144 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 741093000145 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 741093000146 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 741093000147 active site 741093000148 tetramer interface [polypeptide binding]; other site 741093000149 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 741093000150 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 741093000151 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 741093000152 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 741093000153 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 741093000154 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 741093000155 catalytic site [active] 741093000156 subunit interface [polypeptide binding]; other site 741093000157 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 741093000158 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741093000159 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 741093000160 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 741093000161 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741093000162 ATP-grasp domain; Region: ATP-grasp_4; cl17255 741093000163 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 741093000164 IMP binding site; other site 741093000165 dimer interface [polypeptide binding]; other site 741093000166 interdomain contacts; other site 741093000167 partial ornithine binding site; other site 741093000168 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 741093000169 carnitine operon protein CaiE; Provisional; Region: PRK13627 741093000170 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 741093000171 putative trimer interface [polypeptide binding]; other site 741093000172 putative metal binding site [ion binding]; other site 741093000173 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 741093000174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741093000175 substrate binding site [chemical binding]; other site 741093000176 oxyanion hole (OAH) forming residues; other site 741093000177 trimer interface [polypeptide binding]; other site 741093000178 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 741093000179 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 741093000180 acyl-activating enzyme (AAE) consensus motif; other site 741093000181 putative AMP binding site [chemical binding]; other site 741093000182 putative active site [active] 741093000183 putative CoA binding site [chemical binding]; other site 741093000184 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 741093000185 CoA-transferase family III; Region: CoA_transf_3; pfam02515 741093000186 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 741093000187 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 741093000188 active site 741093000189 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 741093000190 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 741093000191 Ligand binding site [chemical binding]; other site 741093000192 Electron transfer flavoprotein domain; Region: ETF; pfam01012 741093000193 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 741093000194 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 741093000195 Ligand binding site [chemical binding]; other site 741093000196 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 741093000197 putative oxidoreductase FixC; Provisional; Region: PRK10157 741093000198 ferredoxin-like protein FixX; Provisional; Region: PRK15449 741093000199 benzoate transport; Region: 2A0115; TIGR00895 741093000200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093000201 putative substrate translocation pore; other site 741093000202 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 741093000203 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 741093000204 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 741093000205 TrkA-N domain; Region: TrkA_N; pfam02254 741093000206 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 741093000207 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 741093000208 folate binding site [chemical binding]; other site 741093000209 NADP+ binding site [chemical binding]; other site 741093000210 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 741093000211 CcdB protein; Region: CcdB; pfam01845 741093000212 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 741093000213 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 741093000214 active site 741093000215 metal binding site [ion binding]; metal-binding site 741093000216 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 741093000217 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 741093000218 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 741093000219 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 741093000220 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 741093000221 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 741093000222 SurA N-terminal domain; Region: SurA_N; pfam09312 741093000223 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 741093000224 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 741093000225 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 741093000226 OstA-like protein; Region: OstA; pfam03968 741093000227 Organic solvent tolerance protein; Region: OstA_C; pfam04453 741093000228 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 741093000229 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 741093000230 putative metal binding site [ion binding]; other site 741093000231 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 741093000232 HSP70 interaction site [polypeptide binding]; other site 741093000233 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 741093000234 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741093000235 active site 741093000236 ATP-dependent helicase HepA; Validated; Region: PRK04914 741093000237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093000238 ATP binding site [chemical binding]; other site 741093000239 putative Mg++ binding site [ion binding]; other site 741093000240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093000241 nucleotide binding region [chemical binding]; other site 741093000242 ATP-binding site [chemical binding]; other site 741093000243 DNA polymerase II; Reviewed; Region: PRK05762 741093000244 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 741093000245 active site 741093000246 catalytic site [active] 741093000247 substrate binding site [chemical binding]; other site 741093000248 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 741093000249 active site 741093000250 metal-binding site 741093000251 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 741093000252 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 741093000253 intersubunit interface [polypeptide binding]; other site 741093000254 active site 741093000255 Zn2+ binding site [ion binding]; other site 741093000256 L-arabinose isomerase; Provisional; Region: PRK02929 741093000257 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 741093000258 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 741093000259 trimer interface [polypeptide binding]; other site 741093000260 putative substrate binding site [chemical binding]; other site 741093000261 putative metal binding site [ion binding]; other site 741093000262 ribulokinase; Provisional; Region: PRK04123 741093000263 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 741093000264 N- and C-terminal domain interface [polypeptide binding]; other site 741093000265 active site 741093000266 MgATP binding site [chemical binding]; other site 741093000267 catalytic site [active] 741093000268 metal binding site [ion binding]; metal-binding site 741093000269 carbohydrate binding site [chemical binding]; other site 741093000270 homodimer interface [polypeptide binding]; other site 741093000271 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 741093000272 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741093000273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093000274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093000275 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741093000276 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 741093000277 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 741093000278 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 741093000279 Walker A/P-loop; other site 741093000280 ATP binding site [chemical binding]; other site 741093000281 Q-loop/lid; other site 741093000282 ABC transporter signature motif; other site 741093000283 Walker B; other site 741093000284 D-loop; other site 741093000285 H-loop/switch region; other site 741093000286 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 741093000287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093000288 dimer interface [polypeptide binding]; other site 741093000289 conserved gate region; other site 741093000290 putative PBP binding loops; other site 741093000291 ABC-ATPase subunit interface; other site 741093000292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093000293 dimer interface [polypeptide binding]; other site 741093000294 conserved gate region; other site 741093000295 putative PBP binding loops; other site 741093000296 ABC-ATPase subunit interface; other site 741093000297 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 741093000298 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 741093000299 transcriptional regulator SgrR; Provisional; Region: PRK13626 741093000300 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 741093000301 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 741093000302 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 741093000303 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 741093000304 substrate binding site [chemical binding]; other site 741093000305 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 741093000306 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 741093000307 substrate binding site [chemical binding]; other site 741093000308 ligand binding site [chemical binding]; other site 741093000309 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 741093000310 tartrate dehydrogenase; Region: TTC; TIGR02089 741093000311 2-isopropylmalate synthase; Validated; Region: PRK00915 741093000312 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 741093000313 active site 741093000314 catalytic residues [active] 741093000315 metal binding site [ion binding]; metal-binding site 741093000316 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 741093000317 leu operon leader peptide; Provisional; Region: PRK09925 741093000318 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 741093000319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093000320 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 741093000321 putative substrate binding pocket [chemical binding]; other site 741093000322 putative dimerization interface [polypeptide binding]; other site 741093000323 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 741093000324 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741093000325 PYR/PP interface [polypeptide binding]; other site 741093000326 dimer interface [polypeptide binding]; other site 741093000327 TPP binding site [chemical binding]; other site 741093000328 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741093000329 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 741093000330 TPP-binding site [chemical binding]; other site 741093000331 dimer interface [polypeptide binding]; other site 741093000332 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 741093000333 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 741093000334 putative valine binding site [chemical binding]; other site 741093000335 dimer interface [polypeptide binding]; other site 741093000336 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 741093000337 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 741093000338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093000339 DNA binding site [nucleotide binding] 741093000340 domain linker motif; other site 741093000341 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 741093000342 dimerization interface [polypeptide binding]; other site 741093000343 ligand binding site [chemical binding]; other site 741093000344 mraZ protein; Region: TIGR00242 741093000345 MraZ protein; Region: MraZ; pfam02381 741093000346 MraZ protein; Region: MraZ; pfam02381 741093000347 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 741093000348 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 741093000349 cell division protein FtsL; Provisional; Region: PRK10772 741093000350 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 741093000351 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 741093000352 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 741093000353 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 741093000354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741093000355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741093000356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741093000357 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 741093000358 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741093000359 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741093000360 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741093000361 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 741093000362 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 741093000363 Mg++ binding site [ion binding]; other site 741093000364 putative catalytic motif [active] 741093000365 putative substrate binding site [chemical binding]; other site 741093000366 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 741093000367 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741093000368 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741093000369 cell division protein FtsW; Provisional; Region: PRK10774 741093000370 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 741093000371 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 741093000372 active site 741093000373 homodimer interface [polypeptide binding]; other site 741093000374 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 741093000375 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741093000376 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741093000377 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741093000378 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 741093000379 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 741093000380 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 741093000381 cell division protein FtsQ; Provisional; Region: PRK10775 741093000382 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 741093000383 Cell division protein FtsQ; Region: FtsQ; pfam03799 741093000384 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 741093000385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093000386 Cell division protein FtsA; Region: FtsA; pfam14450 741093000387 cell division protein FtsZ; Validated; Region: PRK09330 741093000388 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 741093000389 nucleotide binding site [chemical binding]; other site 741093000390 SulA interaction site; other site 741093000391 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 741093000392 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 741093000393 SecA regulator SecM; Provisional; Region: PRK02943 741093000394 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 741093000395 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 741093000396 SEC-C motif; Region: SEC-C; pfam02810 741093000397 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 741093000398 active site 741093000399 8-oxo-dGMP binding site [chemical binding]; other site 741093000400 nudix motif; other site 741093000401 metal binding site [ion binding]; metal-binding site 741093000402 DNA gyrase inhibitor; Reviewed; Region: PRK00418 741093000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 741093000404 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 741093000405 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 741093000406 CoA-binding site [chemical binding]; other site 741093000407 ATP-binding [chemical binding]; other site 741093000408 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 741093000409 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 741093000410 active site 741093000411 type IV pilin biogenesis protein; Provisional; Region: PRK10573 741093000412 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741093000413 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741093000414 hypothetical protein; Provisional; Region: PRK10436 741093000415 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 741093000416 Walker A motif; other site 741093000417 ATP binding site [chemical binding]; other site 741093000418 Walker B motif; other site 741093000419 putative major pilin subunit; Provisional; Region: PRK10574 741093000420 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 741093000421 Pilin (bacterial filament); Region: Pilin; pfam00114 741093000422 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 741093000423 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 741093000424 dimerization interface [polypeptide binding]; other site 741093000425 active site 741093000426 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 741093000427 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 741093000428 amidase catalytic site [active] 741093000429 Zn binding residues [ion binding]; other site 741093000430 substrate binding site [chemical binding]; other site 741093000431 regulatory protein AmpE; Provisional; Region: PRK10987 741093000432 aromatic amino acid transporter; Provisional; Region: PRK10238 741093000433 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741093000434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093000435 DNA-binding site [nucleotide binding]; DNA binding site 741093000436 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741093000437 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 741093000438 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 741093000439 dimer interface [polypeptide binding]; other site 741093000440 TPP-binding site [chemical binding]; other site 741093000441 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 741093000442 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741093000443 E3 interaction surface; other site 741093000444 lipoyl attachment site [posttranslational modification]; other site 741093000445 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741093000446 E3 interaction surface; other site 741093000447 lipoyl attachment site [posttranslational modification]; other site 741093000448 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741093000449 E3 interaction surface; other site 741093000450 lipoyl attachment site [posttranslational modification]; other site 741093000451 e3 binding domain; Region: E3_binding; pfam02817 741093000452 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 741093000453 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 741093000454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741093000455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093000456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741093000457 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 741093000458 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 741093000459 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 741093000460 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 741093000461 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 741093000462 substrate binding site [chemical binding]; other site 741093000463 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 741093000464 substrate binding site [chemical binding]; other site 741093000465 ligand binding site [chemical binding]; other site 741093000466 hypothetical protein; Provisional; Region: PRK05248 741093000467 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 741093000468 spermidine synthase; Provisional; Region: PRK00811 741093000469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093000470 S-adenosylmethionine binding site [chemical binding]; other site 741093000471 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 741093000472 multicopper oxidase; Provisional; Region: PRK10965 741093000473 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 741093000474 Multicopper oxidase; Region: Cu-oxidase; pfam00394 741093000475 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 741093000476 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 741093000477 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 741093000478 Trp docking motif [polypeptide binding]; other site 741093000479 putative active site [active] 741093000480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093000481 active site 741093000482 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 741093000483 active site clefts [active] 741093000484 zinc binding site [ion binding]; other site 741093000485 dimer interface [polypeptide binding]; other site 741093000486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 741093000487 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741093000488 Walker A/P-loop; other site 741093000489 ATP binding site [chemical binding]; other site 741093000490 Q-loop/lid; other site 741093000491 ABC transporter signature motif; other site 741093000492 Walker B; other site 741093000493 D-loop; other site 741093000494 H-loop/switch region; other site 741093000495 inner membrane transport permease; Provisional; Region: PRK15066 741093000496 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741093000497 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 741093000498 active pocket/dimerization site; other site 741093000499 active site 741093000500 phosphorylation site [posttranslational modification] 741093000501 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 741093000502 putative active site [active] 741093000503 putative metal binding site [ion binding]; other site 741093000504 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 741093000505 tetramerization interface [polypeptide binding]; other site 741093000506 active site 741093000507 Uncharacterized conserved protein [Function unknown]; Region: COG5464 741093000508 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 741093000509 pantoate--beta-alanine ligase; Region: panC; TIGR00018 741093000510 Pantoate-beta-alanine ligase; Region: PanC; cd00560 741093000511 active site 741093000512 ATP-binding site [chemical binding]; other site 741093000513 pantoate-binding site; other site 741093000514 HXXH motif; other site 741093000515 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 741093000516 oligomerization interface [polypeptide binding]; other site 741093000517 active site 741093000518 metal binding site [ion binding]; metal-binding site 741093000519 Fimbrial protein; Region: Fimbrial; cl01416 741093000520 putative fimbrial protein StaF; Provisional; Region: PRK15262 741093000521 putative fimbrial protein StaE; Provisional; Region: PRK15263 741093000522 Fimbrial protein; Region: Fimbrial; cl01416 741093000523 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 741093000524 PapC N-terminal domain; Region: PapC_N; pfam13954 741093000525 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093000526 PapC C-terminal domain; Region: PapC_C; pfam13953 741093000527 putative chaperone protein EcpD; Provisional; Region: PRK09926 741093000528 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093000529 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093000530 Fimbrial protein; Region: Fimbrial; cl01416 741093000531 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 741093000532 catalytic center binding site [active] 741093000533 ATP binding site [chemical binding]; other site 741093000534 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 741093000535 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 741093000536 active site 741093000537 NTP binding site [chemical binding]; other site 741093000538 metal binding triad [ion binding]; metal-binding site 741093000539 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 741093000540 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 741093000541 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 741093000542 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 741093000543 active site 741093000544 nucleotide binding site [chemical binding]; other site 741093000545 HIGH motif; other site 741093000546 KMSKS motif; other site 741093000547 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 741093000548 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 741093000549 2'-5' RNA ligase; Provisional; Region: PRK15124 741093000550 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 741093000551 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 741093000552 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 741093000553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093000554 ATP binding site [chemical binding]; other site 741093000555 putative Mg++ binding site [ion binding]; other site 741093000556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093000557 nucleotide binding region [chemical binding]; other site 741093000558 ATP-binding site [chemical binding]; other site 741093000559 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 741093000560 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 741093000561 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 741093000562 Transglycosylase; Region: Transgly; pfam00912 741093000563 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 741093000564 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 741093000565 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093000566 N-terminal plug; other site 741093000567 ligand-binding site [chemical binding]; other site 741093000568 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 741093000569 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741093000570 Walker A/P-loop; other site 741093000571 ATP binding site [chemical binding]; other site 741093000572 Q-loop/lid; other site 741093000573 ABC transporter signature motif; other site 741093000574 Walker B; other site 741093000575 D-loop; other site 741093000576 H-loop/switch region; other site 741093000577 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 741093000578 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 741093000579 siderophore binding site; other site 741093000580 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741093000581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093000582 ABC-ATPase subunit interface; other site 741093000583 dimer interface [polypeptide binding]; other site 741093000584 putative PBP binding regions; other site 741093000585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093000586 ABC-ATPase subunit interface; other site 741093000587 dimer interface [polypeptide binding]; other site 741093000588 putative PBP binding regions; other site 741093000589 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 741093000590 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093000591 inhibitor-cofactor binding pocket; inhibition site 741093000592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093000593 catalytic residue [active] 741093000594 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 741093000595 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 741093000596 Cl- selectivity filter; other site 741093000597 Cl- binding residues [ion binding]; other site 741093000598 pore gating glutamate residue; other site 741093000599 dimer interface [polypeptide binding]; other site 741093000600 H+/Cl- coupling transport residue; other site 741093000601 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 741093000602 hypothetical protein; Provisional; Region: PRK10578 741093000603 UPF0126 domain; Region: UPF0126; pfam03458 741093000604 UPF0126 domain; Region: UPF0126; pfam03458 741093000605 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 741093000606 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 741093000607 cobalamin binding residues [chemical binding]; other site 741093000608 putative BtuC binding residues; other site 741093000609 dimer interface [polypeptide binding]; other site 741093000610 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 741093000611 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 741093000612 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 741093000613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741093000614 Zn2+ binding site [ion binding]; other site 741093000615 Mg2+ binding site [ion binding]; other site 741093000616 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 741093000617 serine endoprotease; Provisional; Region: PRK10942 741093000618 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 741093000619 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741093000620 protein binding site [polypeptide binding]; other site 741093000621 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741093000622 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 741093000623 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 741093000624 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 741093000625 hypothetical protein; Provisional; Region: PRK13677 741093000626 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 741093000627 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 741093000628 trimer interface [polypeptide binding]; other site 741093000629 active site 741093000630 substrate binding site [chemical binding]; other site 741093000631 CoA binding site [chemical binding]; other site 741093000632 PII uridylyl-transferase; Provisional; Region: PRK05007 741093000633 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 741093000634 metal binding triad; other site 741093000635 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 741093000636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741093000637 Zn2+ binding site [ion binding]; other site 741093000638 Mg2+ binding site [ion binding]; other site 741093000639 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 741093000640 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 741093000641 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 741093000642 active site 741093000643 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 741093000644 rRNA interaction site [nucleotide binding]; other site 741093000645 S8 interaction site; other site 741093000646 putative laminin-1 binding site; other site 741093000647 elongation factor Ts; Provisional; Region: tsf; PRK09377 741093000648 UBA/TS-N domain; Region: UBA; pfam00627 741093000649 Elongation factor TS; Region: EF_TS; pfam00889 741093000650 Elongation factor TS; Region: EF_TS; pfam00889 741093000651 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 741093000652 putative nucleotide binding site [chemical binding]; other site 741093000653 uridine monophosphate binding site [chemical binding]; other site 741093000654 homohexameric interface [polypeptide binding]; other site 741093000655 ribosome recycling factor; Reviewed; Region: frr; PRK00083 741093000656 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 741093000657 hinge region; other site 741093000658 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 741093000659 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 741093000660 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 741093000661 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 741093000662 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 741093000663 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 741093000664 catalytic residue [active] 741093000665 putative FPP diphosphate binding site; other site 741093000666 putative FPP binding hydrophobic cleft; other site 741093000667 dimer interface [polypeptide binding]; other site 741093000668 putative IPP diphosphate binding site; other site 741093000669 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 741093000670 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 741093000671 zinc metallopeptidase RseP; Provisional; Region: PRK10779 741093000672 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 741093000673 active site 741093000674 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 741093000675 protein binding site [polypeptide binding]; other site 741093000676 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 741093000677 putative substrate binding region [chemical binding]; other site 741093000678 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 741093000679 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741093000680 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741093000681 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741093000682 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741093000683 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741093000684 Surface antigen; Region: Bac_surface_Ag; pfam01103 741093000685 periplasmic chaperone; Provisional; Region: PRK10780 741093000686 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 741093000687 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 741093000688 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 741093000689 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 741093000690 trimer interface [polypeptide binding]; other site 741093000691 active site 741093000692 UDP-GlcNAc binding site [chemical binding]; other site 741093000693 lipid binding site [chemical binding]; lipid-binding site 741093000694 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 741093000695 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 741093000696 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 741093000697 active site 741093000698 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 741093000699 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 741093000700 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 741093000701 RNA/DNA hybrid binding site [nucleotide binding]; other site 741093000702 active site 741093000703 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 741093000704 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 741093000705 putative active site [active] 741093000706 putative PHP Thumb interface [polypeptide binding]; other site 741093000707 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 741093000708 generic binding surface II; other site 741093000709 generic binding surface I; other site 741093000710 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 741093000711 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 741093000712 lysine decarboxylase LdcC; Provisional; Region: PRK15399 741093000713 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741093000714 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741093000715 homodimer interface [polypeptide binding]; other site 741093000716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093000717 catalytic residue [active] 741093000718 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741093000719 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 741093000720 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741093000721 putative metal binding site [ion binding]; other site 741093000722 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 741093000723 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 741093000724 Ligand Binding Site [chemical binding]; other site 741093000725 TilS substrate binding domain; Region: TilS; pfam09179 741093000726 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 741093000727 Rho-binding antiterminator; Provisional; Region: PRK11625 741093000728 hypothetical protein; Provisional; Region: PRK04964 741093000729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 741093000730 hypothetical protein; Provisional; Region: PRK09256 741093000731 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 741093000732 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 741093000733 NlpE N-terminal domain; Region: NlpE; pfam04170 741093000734 hypothetical protein; Provisional; Region: PRK11479 741093000735 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 741093000736 prolyl-tRNA synthetase; Provisional; Region: PRK09194 741093000737 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 741093000738 dimer interface [polypeptide binding]; other site 741093000739 motif 1; other site 741093000740 active site 741093000741 motif 2; other site 741093000742 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 741093000743 putative deacylase active site [active] 741093000744 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 741093000745 active site 741093000746 motif 3; other site 741093000747 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 741093000748 anticodon binding site; other site 741093000749 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 741093000750 homodimer interaction site [polypeptide binding]; other site 741093000751 cofactor binding site; other site 741093000752 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 741093000753 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 741093000754 lipoprotein, YaeC family; Region: TIGR00363 741093000755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093000756 dimer interface [polypeptide binding]; other site 741093000757 conserved gate region; other site 741093000758 ABC-ATPase subunit interface; other site 741093000759 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 741093000760 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 741093000761 Walker A/P-loop; other site 741093000762 ATP binding site [chemical binding]; other site 741093000763 Q-loop/lid; other site 741093000764 ABC transporter signature motif; other site 741093000765 Walker B; other site 741093000766 D-loop; other site 741093000767 H-loop/switch region; other site 741093000768 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 741093000769 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 741093000770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093000771 active site 741093000772 motif I; other site 741093000773 motif II; other site 741093000774 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093000775 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093000776 active site 741093000777 catalytic tetrad [active] 741093000778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093000779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093000780 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 741093000781 putative effector binding pocket; other site 741093000782 dimerization interface [polypeptide binding]; other site 741093000783 hypothetical protein; Provisional; Region: PRK05421 741093000784 putative catalytic site [active] 741093000785 putative metal binding site [ion binding]; other site 741093000786 putative phosphate binding site [ion binding]; other site 741093000787 putative catalytic site [active] 741093000788 putative phosphate binding site [ion binding]; other site 741093000789 putative metal binding site [ion binding]; other site 741093000790 Methyltransferase domain; Region: Methyltransf_31; pfam13847 741093000791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093000792 S-adenosylmethionine binding site [chemical binding]; other site 741093000793 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 741093000794 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093000795 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093000796 catalytic residue [active] 741093000797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093000798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093000799 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 741093000800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093000801 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 741093000802 RNA/DNA hybrid binding site [nucleotide binding]; other site 741093000803 active site 741093000804 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 741093000805 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 741093000806 active site 741093000807 catalytic site [active] 741093000808 substrate binding site [chemical binding]; other site 741093000809 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741093000810 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 741093000811 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 741093000812 ImpA domain protein; Region: DUF3702; pfam12486 741093000813 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 741093000814 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 741093000815 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 741093000816 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 741093000817 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 741093000818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093000819 Walker A motif; other site 741093000820 ATP binding site [chemical binding]; other site 741093000821 Walker B motif; other site 741093000822 arginine finger; other site 741093000823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093000824 Walker A motif; other site 741093000825 ATP binding site [chemical binding]; other site 741093000826 Walker B motif; other site 741093000827 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 741093000828 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 741093000829 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 741093000830 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 741093000831 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 741093000832 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 741093000833 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 741093000834 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 741093000835 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 741093000836 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 741093000837 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 741093000838 Protein of unknown function (DUF877); Region: DUF877; pfam05943 741093000839 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 741093000840 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 741093000841 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741093000842 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 741093000843 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741093000844 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741093000845 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741093000846 PAAR motif; Region: PAAR_motif; cl15808 741093000847 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093000848 RHS Repeat; Region: RHS_repeat; cl11982 741093000849 RHS Repeat; Region: RHS_repeat; pfam05593 741093000850 RHS Repeat; Region: RHS_repeat; pfam05593 741093000851 RHS Repeat; Region: RHS_repeat; cl11982 741093000852 RHS Repeat; Region: RHS_repeat; cl11982 741093000853 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093000854 RHS Repeat; Region: RHS_repeat; pfam05593 741093000855 RHS Repeat; Region: RHS_repeat; pfam05593 741093000856 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 741093000857 RHS protein; Region: RHS; pfam03527 741093000858 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093000859 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741093000860 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 741093000861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741093000862 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093000863 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093000864 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093000865 Erythromycin esterase; Region: Erythro_esteras; cl17110 741093000866 RHS protein; Region: RHS; pfam03527 741093000867 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093000868 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 741093000869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741093000870 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093000871 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093000872 C-N hydrolase family amidase; Provisional; Region: PRK10438 741093000873 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 741093000874 putative active site [active] 741093000875 catalytic triad [active] 741093000876 dimer interface [polypeptide binding]; other site 741093000877 multimer interface [polypeptide binding]; other site 741093000878 C-lysozyme inhibitor; Provisional; Region: PRK09993 741093000879 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 741093000880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 741093000881 active site 741093000882 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 741093000883 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 741093000884 dimer interface [polypeptide binding]; other site 741093000885 active site 741093000886 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 741093000887 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 741093000888 putative active site [active] 741093000889 putative dimer interface [polypeptide binding]; other site 741093000890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 741093000891 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093000892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 741093000893 RelB antitoxin; Region: RelB; cl01171 741093000894 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093000895 NlpC/P60 family; Region: NLPC_P60; pfam00877 741093000896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 741093000897 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 741093000898 FHIPEP family; Region: FHIPEP; pfam00771 741093000899 hypothetical protein; Validated; Region: PRK06778 741093000900 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093000901 ligand binding site [chemical binding]; other site 741093000902 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 741093000903 active site 741093000904 DNA polymerase IV; Validated; Region: PRK02406 741093000905 DNA binding site [nucleotide binding] 741093000906 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 741093000907 putative toxin YafO; Provisional; Region: PRK09885 741093000908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741093000909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093000910 Coenzyme A binding pocket [chemical binding]; other site 741093000911 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 741093000912 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 741093000913 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 741093000914 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 741093000915 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 741093000916 metal binding site [ion binding]; metal-binding site 741093000917 dimer interface [polypeptide binding]; other site 741093000918 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093000919 active site 741093000920 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 741093000921 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 741093000922 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093000923 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741093000924 trimer interface [polypeptide binding]; other site 741093000925 eyelet of channel; other site 741093000926 gamma-glutamyl kinase; Provisional; Region: PRK05429 741093000927 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 741093000928 nucleotide binding site [chemical binding]; other site 741093000929 homotetrameric interface [polypeptide binding]; other site 741093000930 putative phosphate binding site [ion binding]; other site 741093000931 putative allosteric binding site; other site 741093000932 PUA domain; Region: PUA; pfam01472 741093000933 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 741093000934 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 741093000935 putative catalytic cysteine [active] 741093000936 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093000937 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 741093000938 Int/Topo IB signature motif; other site 741093000939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093000940 non-specific DNA binding site [nucleotide binding]; other site 741093000941 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741093000942 salt bridge; other site 741093000943 sequence-specific DNA binding site [nucleotide binding]; other site 741093000944 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093000945 Catalytic site [active] 741093000946 Cro; Region: Cro; pfam09048 741093000947 Bacteriophage CII protein; Region: Phage_CII; pfam05269 741093000948 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741093000949 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741093000950 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 741093000951 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 741093000952 catalytic residues [active] 741093000953 catalytic nucleophile [active] 741093000954 Presynaptic Site I dimer interface [polypeptide binding]; other site 741093000955 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 741093000956 Synaptic Flat tetramer interface [polypeptide binding]; other site 741093000957 Synaptic Site I dimer interface [polypeptide binding]; other site 741093000958 DNA binding site [nucleotide binding] 741093000959 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 741093000960 DNA-binding interface [nucleotide binding]; DNA binding site 741093000961 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 741093000962 GIY-YIG motif/motif A; other site 741093000963 putative active site [active] 741093000964 putative metal binding site [ion binding]; other site 741093000965 transcriptional regulator YdeO; Provisional; Region: PRK09940 741093000966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093000967 Integrase core domain; Region: rve; pfam00665 741093000968 Integrase core domain; Region: rve_3; pfam13683 741093000969 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 741093000970 Transposase; Region: HTH_Tnp_1; cl17663 741093000971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093000972 putative transposase OrfB; Reviewed; Region: PHA02517 741093000973 HTH-like domain; Region: HTH_21; pfam13276 741093000974 Integrase core domain; Region: rve; pfam00665 741093000975 Integrase core domain; Region: rve_3; pfam13683 741093000976 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093000977 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093000978 active site 741093000979 Int/Topo IB signature motif; other site 741093000980 Restriction endonuclease; Region: Mrr_cat; pfam04471 741093000981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 741093000982 Walker A/P-loop; other site 741093000983 ATP binding site [chemical binding]; other site 741093000984 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 741093000985 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 741093000986 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 741093000987 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 741093000988 Ash protein family; Region: Phage_ASH; pfam10554 741093000989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 741093000990 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 741093000991 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 741093000992 active site 741093000993 metal binding site [ion binding]; metal-binding site 741093000994 interdomain interaction site; other site 741093000995 D5 N terminal like; Region: D5_N; smart00885 741093000996 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 741093000997 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 741093000998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093000999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093001000 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741093001001 putative effector binding pocket; other site 741093001002 putative dimerization interface [polypeptide binding]; other site 741093001003 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 741093001004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741093001005 NAD(P) binding site [chemical binding]; other site 741093001006 active site 741093001007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093001008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093001009 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741093001010 putative effector binding pocket; other site 741093001011 putative dimerization interface [polypeptide binding]; other site 741093001012 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 741093001013 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741093001014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001015 putative substrate translocation pore; other site 741093001016 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 741093001017 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 741093001018 XdhC Rossmann domain; Region: XdhC_C; pfam13478 741093001019 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 741093001020 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 741093001021 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 741093001022 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 741093001023 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 741093001024 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 741093001025 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093001026 catalytic loop [active] 741093001027 iron binding site [ion binding]; other site 741093001028 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 741093001029 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 741093001030 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 741093001031 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093001032 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 741093001033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741093001034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093001035 DNA binding residues [nucleotide binding] 741093001036 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 741093001037 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 741093001038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093001039 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093001040 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093001041 homodimer interface [polypeptide binding]; other site 741093001042 putative GKAP docking site [polypeptide binding]; other site 741093001043 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093001044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093001045 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093001046 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093001047 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093001048 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741093001049 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 741093001050 putative active site [active] 741093001051 putative FMN binding site [chemical binding]; other site 741093001052 putative substrate binding site [chemical binding]; other site 741093001053 putative catalytic residue [active] 741093001054 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 741093001055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093001056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093001057 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741093001058 putative effector binding pocket; other site 741093001059 putative dimerization interface [polypeptide binding]; other site 741093001060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093001061 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093001062 active site 741093001063 catalytic tetrad [active] 741093001064 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 741093001065 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093001066 Filamin/ABP280 repeat; Region: Filamin; pfam00630 741093001067 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093001068 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093001069 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093001070 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 741093001071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093001072 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 741093001073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093001074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093001075 active site 741093001076 catalytic tetrad [active] 741093001077 Predicted membrane protein [Function unknown]; Region: COG3059 741093001078 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093001079 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 741093001080 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741093001081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093001082 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741093001083 Cupin; Region: Cupin_6; pfam12852 741093001084 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741093001085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093001086 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 741093001087 Cysteine-rich domain; Region: CCG; pfam02754 741093001088 Cysteine-rich domain; Region: CCG; pfam02754 741093001089 iron-sulfur cluster-binding protein; Region: TIGR00273 741093001090 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 741093001091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093001092 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 741093001093 Uncharacterized conserved protein [Function unknown]; Region: COG1556 741093001094 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093001095 choline dehydrogenase; Validated; Region: PRK02106 741093001096 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741093001097 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 741093001098 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 741093001099 tetrameric interface [polypeptide binding]; other site 741093001100 NAD binding site [chemical binding]; other site 741093001101 catalytic residues [active] 741093001102 transcriptional regulator BetI; Validated; Region: PRK00767 741093001103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093001104 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 741093001105 choline transport protein BetT; Provisional; Region: PRK09928 741093001106 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 741093001107 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741093001108 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093001109 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093001110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093001111 DNA binding residues [nucleotide binding] 741093001112 dimerization interface [polypeptide binding]; other site 741093001113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093001114 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 741093001115 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 741093001116 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 741093001117 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 741093001118 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 741093001119 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 741093001120 CoA binding domain; Region: CoA_binding; pfam02629 741093001121 CoA-ligase; Region: Ligase_CoA; pfam00549 741093001122 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 741093001123 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 741093001124 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 741093001125 putative substrate binding site [chemical binding]; other site 741093001126 nucleotide binding site [chemical binding]; other site 741093001127 nucleotide binding site [chemical binding]; other site 741093001128 homodimer interface [polypeptide binding]; other site 741093001129 putative deaminase; Validated; Region: PRK06846 741093001130 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 741093001131 active site 741093001132 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 741093001133 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 741093001134 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741093001135 ligand binding site [chemical binding]; other site 741093001136 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741093001137 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093001138 Walker A/P-loop; other site 741093001139 ATP binding site [chemical binding]; other site 741093001140 Q-loop/lid; other site 741093001141 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093001142 Q-loop/lid; other site 741093001143 ABC transporter signature motif; other site 741093001144 Walker B; other site 741093001145 D-loop; other site 741093001146 H-loop/switch region; other site 741093001147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 741093001148 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093001149 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093001150 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093001151 TM-ABC transporter signature motif; other site 741093001152 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093001153 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093001154 TM-ABC transporter signature motif; other site 741093001155 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 741093001156 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 741093001157 putative NAD(P) binding site [chemical binding]; other site 741093001158 putative substrate binding site [chemical binding]; other site 741093001159 catalytic Zn binding site [ion binding]; other site 741093001160 structural Zn binding site [ion binding]; other site 741093001161 dimer interface [polypeptide binding]; other site 741093001162 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 741093001163 hypothetical protein; Provisional; Region: PRK09929 741093001164 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 741093001165 Propionate catabolism activator; Region: PrpR_N; pfam06506 741093001166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093001167 Walker A motif; other site 741093001168 ATP binding site [chemical binding]; other site 741093001169 Walker B motif; other site 741093001170 arginine finger; other site 741093001171 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741093001172 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 741093001173 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 741093001174 tetramer interface [polypeptide binding]; other site 741093001175 active site 741093001176 Mg2+/Mn2+ binding site [ion binding]; other site 741093001177 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 741093001178 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 741093001179 dimer interface [polypeptide binding]; other site 741093001180 active site 741093001181 citrylCoA binding site [chemical binding]; other site 741093001182 oxalacetate/citrate binding site [chemical binding]; other site 741093001183 coenzyme A binding site [chemical binding]; other site 741093001184 catalytic triad [active] 741093001185 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 741093001186 2-methylcitrate dehydratase; Region: prpD; TIGR02330 741093001187 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 741093001188 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 741093001189 acyl-activating enzyme (AAE) consensus motif; other site 741093001190 putative AMP binding site [chemical binding]; other site 741093001191 putative active site [active] 741093001192 putative CoA binding site [chemical binding]; other site 741093001193 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 741093001194 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 741093001195 Na binding site [ion binding]; other site 741093001196 putative substrate binding site [chemical binding]; other site 741093001197 cytosine deaminase; Provisional; Region: PRK09230 741093001198 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 741093001199 active site 741093001200 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 741093001201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093001202 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 741093001203 dimerization interface [polypeptide binding]; other site 741093001204 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 741093001205 active site clefts [active] 741093001206 zinc binding site [ion binding]; other site 741093001207 dimer interface [polypeptide binding]; other site 741093001208 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 741093001209 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 741093001210 oligomer interface [polypeptide binding]; other site 741093001211 active site 741093001212 putative cyanate transporter; Provisional; Region: cynX; PRK09705 741093001213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001214 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 741093001215 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 741093001216 active site 741093001217 substrate binding site [chemical binding]; other site 741093001218 trimer interface [polypeptide binding]; other site 741093001219 CoA binding site [chemical binding]; other site 741093001220 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 741093001221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001222 putative substrate translocation pore; other site 741093001223 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 741093001224 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 741093001225 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 741093001226 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 741093001227 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 741093001228 lac repressor; Reviewed; Region: lacI; PRK09526 741093001229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093001230 DNA binding site [nucleotide binding] 741093001231 domain linker motif; other site 741093001232 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 741093001233 ligand binding site [chemical binding]; other site 741093001234 dimerization interface (open form) [polypeptide binding]; other site 741093001235 dimerization interface (closed form) [polypeptide binding]; other site 741093001236 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 741093001237 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741093001238 conserved cys residue [active] 741093001239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093001240 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 741093001241 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 741093001242 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 741093001243 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 741093001244 Bacterial transcriptional regulator; Region: IclR; pfam01614 741093001245 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 741093001246 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741093001247 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 741093001248 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 741093001249 putative active site [active] 741093001250 Fe(II) binding site [ion binding]; other site 741093001251 putative dimer interface [polypeptide binding]; other site 741093001252 putative tetramer interface [polypeptide binding]; other site 741093001253 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 741093001254 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 741093001255 nucleophilic elbow; other site 741093001256 catalytic triad; other site 741093001257 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 741093001258 acetaldehyde dehydrogenase; Validated; Region: PRK08300 741093001259 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741093001260 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 741093001261 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 741093001262 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 741093001263 active site 741093001264 catalytic residues [active] 741093001265 metal binding site [ion binding]; metal-binding site 741093001266 DmpG-like communication domain; Region: DmpG_comm; pfam07836 741093001267 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 741093001268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 741093001271 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 741093001272 S-formylglutathione hydrolase; Region: PLN02442 741093001273 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 741093001274 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 741093001275 substrate binding site [chemical binding]; other site 741093001276 catalytic Zn binding site [ion binding]; other site 741093001277 NAD binding site [chemical binding]; other site 741093001278 structural Zn binding site [ion binding]; other site 741093001279 dimer interface [polypeptide binding]; other site 741093001280 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 741093001281 putative metal binding site [ion binding]; other site 741093001282 putative homodimer interface [polypeptide binding]; other site 741093001283 putative homotetramer interface [polypeptide binding]; other site 741093001284 putative homodimer-homodimer interface [polypeptide binding]; other site 741093001285 putative allosteric switch controlling residues; other site 741093001286 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 741093001287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093001288 Walker A/P-loop; other site 741093001289 ATP binding site [chemical binding]; other site 741093001290 Q-loop/lid; other site 741093001291 ABC transporter signature motif; other site 741093001292 Walker B; other site 741093001293 D-loop; other site 741093001294 H-loop/switch region; other site 741093001295 TOBE domain; Region: TOBE_2; pfam08402 741093001296 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741093001297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093001298 dimer interface [polypeptide binding]; other site 741093001299 conserved gate region; other site 741093001300 putative PBP binding loops; other site 741093001301 ABC-ATPase subunit interface; other site 741093001302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093001303 dimer interface [polypeptide binding]; other site 741093001304 conserved gate region; other site 741093001305 putative PBP binding loops; other site 741093001306 ABC-ATPase subunit interface; other site 741093001307 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741093001308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741093001309 regulatory protein UhpC; Provisional; Region: PRK11663 741093001310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001311 putative substrate translocation pore; other site 741093001312 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 741093001313 MASE1; Region: MASE1; pfam05231 741093001314 Histidine kinase; Region: HisKA_3; pfam07730 741093001315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093001316 ATP binding site [chemical binding]; other site 741093001317 Mg2+ binding site [ion binding]; other site 741093001318 G-X-G motif; other site 741093001319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741093001320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093001321 active site 741093001322 phosphorylation site [posttranslational modification] 741093001323 intermolecular recognition site; other site 741093001324 dimerization interface [polypeptide binding]; other site 741093001325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093001326 DNA binding residues [nucleotide binding] 741093001327 dimerization interface [polypeptide binding]; other site 741093001328 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 741093001329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093001330 substrate binding pocket [chemical binding]; other site 741093001331 membrane-bound complex binding site; other site 741093001332 hinge residues; other site 741093001333 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 741093001334 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741093001335 Walker A/P-loop; other site 741093001336 ATP binding site [chemical binding]; other site 741093001337 Q-loop/lid; other site 741093001338 ABC transporter signature motif; other site 741093001339 Walker B; other site 741093001340 D-loop; other site 741093001341 H-loop/switch region; other site 741093001342 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741093001343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093001344 dimer interface [polypeptide binding]; other site 741093001345 conserved gate region; other site 741093001346 putative PBP binding loops; other site 741093001347 ABC-ATPase subunit interface; other site 741093001348 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 741093001349 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 741093001350 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 741093001351 dimer interface [polypeptide binding]; other site 741093001352 active site 741093001353 Schiff base residues; other site 741093001354 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 741093001355 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093001356 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093001357 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 741093001358 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 741093001359 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741093001360 microcin B17 transporter; Reviewed; Region: PRK11098 741093001361 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 741093001362 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 741093001363 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 741093001364 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 741093001365 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 741093001366 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 741093001367 anti-RssB factor; Provisional; Region: PRK10244 741093001368 alkaline phosphatase; Provisional; Region: PRK10518 741093001369 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 741093001370 dimer interface [polypeptide binding]; other site 741093001371 active site 741093001372 hypothetical protein; Provisional; Region: PRK11505 741093001373 psiF repeat; Region: PsiF_repeat; pfam07769 741093001374 psiF repeat; Region: PsiF_repeat; pfam07769 741093001375 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 741093001376 MASE2 domain; Region: MASE2; pfam05230 741093001377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093001378 metal binding site [ion binding]; metal-binding site 741093001379 active site 741093001380 I-site; other site 741093001381 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 741093001382 pyrroline-5-carboxylate reductase; Region: PLN02688 741093001383 hypothetical protein; Validated; Region: PRK00124 741093001384 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 741093001385 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 741093001386 ADP binding site [chemical binding]; other site 741093001387 magnesium binding site [ion binding]; other site 741093001388 putative shikimate binding site; other site 741093001389 hypothetical protein; Provisional; Region: PRK10380 741093001390 hypothetical protein; Provisional; Region: PRK10481 741093001391 hypothetical protein; Provisional; Region: PRK10579 741093001392 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 741093001393 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 741093001394 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 741093001395 fructokinase; Reviewed; Region: PRK09557 741093001396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093001397 nucleotide binding site [chemical binding]; other site 741093001398 MFS transport protein AraJ; Provisional; Region: PRK10091 741093001399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001400 putative substrate translocation pore; other site 741093001401 exonuclease subunit SbcC; Provisional; Region: PRK10246 741093001402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093001403 Walker A/P-loop; other site 741093001404 ATP binding site [chemical binding]; other site 741093001405 Q-loop/lid; other site 741093001406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093001407 ABC transporter signature motif; other site 741093001408 Walker B; other site 741093001409 D-loop; other site 741093001410 H-loop/switch region; other site 741093001411 exonuclease subunit SbcD; Provisional; Region: PRK10966 741093001412 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 741093001413 active site 741093001414 metal binding site [ion binding]; metal-binding site 741093001415 DNA binding site [nucleotide binding] 741093001416 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 741093001417 transcriptional regulator PhoB; Provisional; Region: PRK10161 741093001418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093001419 active site 741093001420 phosphorylation site [posttranslational modification] 741093001421 intermolecular recognition site; other site 741093001422 dimerization interface [polypeptide binding]; other site 741093001423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093001424 DNA binding site [nucleotide binding] 741093001425 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 741093001426 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 741093001427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093001428 putative active site [active] 741093001429 heme pocket [chemical binding]; other site 741093001430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093001431 dimer interface [polypeptide binding]; other site 741093001432 phosphorylation site [posttranslational modification] 741093001433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093001434 ATP binding site [chemical binding]; other site 741093001435 Mg2+ binding site [ion binding]; other site 741093001436 G-X-G motif; other site 741093001437 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 741093001438 putative proline-specific permease; Provisional; Region: proY; PRK10580 741093001439 Spore germination protein; Region: Spore_permease; cl17796 741093001440 maltodextrin glucosidase; Provisional; Region: PRK10785 741093001441 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 741093001442 homodimer interface [polypeptide binding]; other site 741093001443 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 741093001444 active site 741093001445 homodimer interface [polypeptide binding]; other site 741093001446 catalytic site [active] 741093001447 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 741093001448 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 741093001449 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 741093001450 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 741093001451 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 741093001452 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 741093001453 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 741093001454 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 741093001455 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 741093001456 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 741093001457 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 741093001458 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 741093001459 Protein export membrane protein; Region: SecD_SecF; pfam02355 741093001460 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 741093001461 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 741093001462 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093001463 active site 741093001464 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 741093001465 hypothetical protein; Provisional; Region: PRK11530 741093001466 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 741093001467 ATP cone domain; Region: ATP-cone; pfam03477 741093001468 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 741093001469 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 741093001470 catalytic motif [active] 741093001471 Zn binding site [ion binding]; other site 741093001472 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 741093001473 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 741093001474 homopentamer interface [polypeptide binding]; other site 741093001475 active site 741093001476 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 741093001477 putative RNA binding site [nucleotide binding]; other site 741093001478 thiamine monophosphate kinase; Provisional; Region: PRK05731 741093001479 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 741093001480 ATP binding site [chemical binding]; other site 741093001481 dimerization interface [polypeptide binding]; other site 741093001482 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 741093001483 tetramer interfaces [polypeptide binding]; other site 741093001484 binuclear metal-binding site [ion binding]; other site 741093001485 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 741093001486 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093001487 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093001488 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093001489 active site 741093001490 catalytic tetrad [active] 741093001491 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 741093001492 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 741093001493 TPP-binding site; other site 741093001494 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741093001495 PYR/PP interface [polypeptide binding]; other site 741093001496 dimer interface [polypeptide binding]; other site 741093001497 TPP binding site [chemical binding]; other site 741093001498 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741093001499 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 741093001500 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 741093001501 substrate binding pocket [chemical binding]; other site 741093001502 chain length determination region; other site 741093001503 substrate-Mg2+ binding site; other site 741093001504 catalytic residues [active] 741093001505 aspartate-rich region 1; other site 741093001506 active site lid residues [active] 741093001507 aspartate-rich region 2; other site 741093001508 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 741093001509 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 741093001510 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 741093001511 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 741093001512 Ligand Binding Site [chemical binding]; other site 741093001513 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 741093001514 active site residue [active] 741093001515 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 741093001516 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 741093001517 conserved cys residue [active] 741093001518 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 741093001519 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 741093001520 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 741093001521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 741093001522 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 741093001523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093001525 putative substrate translocation pore; other site 741093001526 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 741093001527 UbiA prenyltransferase family; Region: UbiA; pfam01040 741093001528 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 741093001529 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 741093001530 Subunit I/III interface [polypeptide binding]; other site 741093001531 Subunit III/IV interface [polypeptide binding]; other site 741093001532 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 741093001533 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 741093001534 D-pathway; other site 741093001535 Putative ubiquinol binding site [chemical binding]; other site 741093001536 Low-spin heme (heme b) binding site [chemical binding]; other site 741093001537 Putative water exit pathway; other site 741093001538 Binuclear center (heme o3/CuB) [ion binding]; other site 741093001539 K-pathway; other site 741093001540 Putative proton exit pathway; other site 741093001541 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 741093001542 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 741093001543 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 741093001544 muropeptide transporter; Reviewed; Region: ampG; PRK11902 741093001545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001546 putative substrate translocation pore; other site 741093001547 hypothetical protein; Provisional; Region: PRK11627 741093001548 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 741093001549 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 741093001550 transcriptional regulator BolA; Provisional; Region: PRK11628 741093001551 trigger factor; Provisional; Region: tig; PRK01490 741093001552 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741093001553 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 741093001554 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 741093001555 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 741093001556 oligomer interface [polypeptide binding]; other site 741093001557 active site residues [active] 741093001558 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 741093001559 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 741093001560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093001561 Walker A motif; other site 741093001562 ATP binding site [chemical binding]; other site 741093001563 Walker B motif; other site 741093001564 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 741093001565 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 741093001566 Found in ATP-dependent protease La (LON); Region: LON; smart00464 741093001567 Found in ATP-dependent protease La (LON); Region: LON; smart00464 741093001568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093001569 Walker A motif; other site 741093001570 ATP binding site [chemical binding]; other site 741093001571 Walker B motif; other site 741093001572 arginine finger; other site 741093001573 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 741093001574 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741093001575 IHF dimer interface [polypeptide binding]; other site 741093001576 IHF - DNA interface [nucleotide binding]; other site 741093001577 periplasmic folding chaperone; Provisional; Region: PRK10788 741093001578 SurA N-terminal domain; Region: SurA_N_3; cl07813 741093001579 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 741093001580 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 741093001581 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 741093001582 active site 741093001583 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 741093001584 Ligand Binding Site [chemical binding]; other site 741093001585 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 741093001586 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 741093001587 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 741093001588 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 741093001589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093001590 active site 741093001591 motif I; other site 741093001592 motif II; other site 741093001593 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 741093001594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093001595 putative DNA binding site [nucleotide binding]; other site 741093001596 putative Zn2+ binding site [ion binding]; other site 741093001597 AsnC family; Region: AsnC_trans_reg; pfam01037 741093001598 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093001599 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 741093001600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093001601 Walker A/P-loop; other site 741093001602 ATP binding site [chemical binding]; other site 741093001603 Q-loop/lid; other site 741093001604 ABC transporter signature motif; other site 741093001605 Walker B; other site 741093001606 D-loop; other site 741093001607 H-loop/switch region; other site 741093001608 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 741093001609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093001610 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 741093001611 Walker A/P-loop; other site 741093001612 ATP binding site [chemical binding]; other site 741093001613 Q-loop/lid; other site 741093001614 ABC transporter signature motif; other site 741093001615 Walker B; other site 741093001616 D-loop; other site 741093001617 H-loop/switch region; other site 741093001618 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 741093001619 Nitrogen regulatory protein P-II; Region: P-II; smart00938 741093001620 ammonium transporter; Provisional; Region: PRK10666 741093001621 acyl-CoA thioesterase II; Provisional; Region: PRK10526 741093001622 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 741093001623 active site 741093001624 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 741093001625 catalytic triad [active] 741093001626 dimer interface [polypeptide binding]; other site 741093001627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 741093001628 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 741093001629 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741093001630 DNA binding site [nucleotide binding] 741093001631 active site 741093001632 Uncharacterized conserved protein [Function unknown]; Region: COG5507 741093001633 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 741093001634 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741093001635 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093001636 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 741093001637 maltose O-acetyltransferase; Provisional; Region: PRK10092 741093001638 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 741093001639 active site 741093001640 substrate binding site [chemical binding]; other site 741093001641 trimer interface [polypeptide binding]; other site 741093001642 CoA binding site [chemical binding]; other site 741093001643 gene expression modulator; Provisional; Region: PRK10945 741093001644 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 741093001645 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 741093001646 Protein export membrane protein; Region: SecD_SecF; cl14618 741093001647 Protein export membrane protein; Region: SecD_SecF; cl14618 741093001648 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 741093001649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093001650 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093001651 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 741093001652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093001653 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 741093001654 hypothetical protein; Provisional; Region: PRK11281 741093001655 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 741093001656 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 741093001657 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741093001658 hypothetical protein; Provisional; Region: PRK11038 741093001659 primosomal replication protein N''; Provisional; Region: PRK10093 741093001660 hypothetical protein; Provisional; Region: PRK10527 741093001661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093001662 active site 741093001663 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 741093001664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093001665 Walker A motif; other site 741093001666 ATP binding site [chemical binding]; other site 741093001667 Walker B motif; other site 741093001668 DNA polymerase III subunit delta'; Validated; Region: PRK08485 741093001669 arginine finger; other site 741093001670 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 741093001671 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 741093001672 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 741093001673 hypothetical protein; Validated; Region: PRK00153 741093001674 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 741093001675 RecR protein; Region: RecR; pfam02132 741093001676 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 741093001677 putative active site [active] 741093001678 putative metal-binding site [ion binding]; other site 741093001679 tetramer interface [polypeptide binding]; other site 741093001680 heat shock protein 90; Provisional; Region: PRK05218 741093001681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093001682 ATP binding site [chemical binding]; other site 741093001683 Mg2+ binding site [ion binding]; other site 741093001684 G-X-G motif; other site 741093001685 adenylate kinase; Reviewed; Region: adk; PRK00279 741093001686 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 741093001687 AMP-binding site [chemical binding]; other site 741093001688 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 741093001689 ferrochelatase; Region: hemH; TIGR00109 741093001690 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 741093001691 C-terminal domain interface [polypeptide binding]; other site 741093001692 active site 741093001693 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 741093001694 active site 741093001695 N-terminal domain interface [polypeptide binding]; other site 741093001696 acetyl esterase; Provisional; Region: PRK10162 741093001697 inosine/guanosine kinase; Provisional; Region: PRK15074 741093001698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093001699 putative cation:proton antiport protein; Provisional; Region: PRK10669 741093001700 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 741093001701 TrkA-N domain; Region: TrkA_N; pfam02254 741093001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093001703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093001704 putative substrate translocation pore; other site 741093001705 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 741093001706 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 741093001707 active site 741093001708 metal binding site [ion binding]; metal-binding site 741093001709 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 741093001710 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 741093001711 putative deacylase active site [active] 741093001712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 741093001713 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 741093001714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093001715 non-specific DNA binding site [nucleotide binding]; other site 741093001716 salt bridge; other site 741093001717 sequence-specific DNA binding site [nucleotide binding]; other site 741093001718 copper exporting ATPase; Provisional; Region: copA; PRK10671 741093001719 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 741093001720 metal-binding site [ion binding] 741093001721 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 741093001722 metal-binding site [ion binding] 741093001723 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741093001724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093001725 motif II; other site 741093001726 glutaminase; Reviewed; Region: PRK12356 741093001727 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 741093001728 amino acid transporter; Region: 2A0306; TIGR00909 741093001729 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 741093001730 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001731 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001732 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001733 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001734 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001735 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 741093001736 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001737 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001738 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001739 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001740 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001741 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001742 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001743 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001744 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001745 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001746 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001747 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001748 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001749 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001750 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001751 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001752 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001753 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001754 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001755 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001756 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001757 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001758 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741093001759 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741093001760 Family description; Region: VCBS; pfam13517 741093001761 Family description; Region: VCBS; pfam13517 741093001762 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 741093001763 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 741093001764 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 741093001765 putative active site [active] 741093001766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093001767 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 741093001768 Walker A/P-loop; other site 741093001769 ATP binding site [chemical binding]; other site 741093001770 Q-loop/lid; other site 741093001771 ABC transporter signature motif; other site 741093001772 Walker B; other site 741093001773 D-loop; other site 741093001774 H-loop/switch region; other site 741093001775 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 741093001776 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 741093001777 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093001778 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 741093001779 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 741093001780 DNA binding residues [nucleotide binding] 741093001781 dimer interface [polypeptide binding]; other site 741093001782 copper binding site [ion binding]; other site 741093001783 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 741093001784 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 741093001785 YadA-like C-terminal region; Region: YadA; pfam03895 741093001786 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 741093001787 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 741093001788 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 741093001789 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 741093001790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093001791 Walker A/P-loop; other site 741093001792 ATP binding site [chemical binding]; other site 741093001793 Q-loop/lid; other site 741093001794 ABC transporter signature motif; other site 741093001795 Walker B; other site 741093001796 D-loop; other site 741093001797 H-loop/switch region; other site 741093001798 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 741093001799 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 741093001800 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 741093001801 oxidoreductase; Provisional; Region: PRK08017 741093001802 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 741093001803 NADP binding site [chemical binding]; other site 741093001804 active site 741093001805 steroid binding site; other site 741093001806 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 741093001807 active site 741093001808 catalytic triad [active] 741093001809 oxyanion hole [active] 741093001810 switch loop; other site 741093001811 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 741093001812 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741093001813 Walker A/P-loop; other site 741093001814 ATP binding site [chemical binding]; other site 741093001815 Q-loop/lid; other site 741093001816 ABC transporter signature motif; other site 741093001817 Walker B; other site 741093001818 D-loop; other site 741093001819 H-loop/switch region; other site 741093001820 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 741093001821 FtsX-like permease family; Region: FtsX; pfam02687 741093001822 FtsX-like permease family; Region: FtsX; pfam02687 741093001823 PAAR motif; Region: PAAR_motif; cl15808 741093001824 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093001825 RHS Repeat; Region: RHS_repeat; pfam05593 741093001826 RHS Repeat; Region: RHS_repeat; pfam05593 741093001827 RHS Repeat; Region: RHS_repeat; cl11982 741093001828 RHS Repeat; Region: RHS_repeat; pfam05593 741093001829 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093001830 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 741093001831 RHS Repeat; Region: RHS_repeat; pfam05593 741093001832 RHS protein; Region: RHS; pfam03527 741093001833 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093001834 hypothetical protein; Provisional; Region: PRK14710 741093001835 Winged helix-turn helix; Region: HTH_29; pfam13551 741093001836 Helix-turn-helix domain; Region: HTH_28; pfam13518 741093001837 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 741093001838 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 741093001839 active site residue [active] 741093001840 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 741093001841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093001842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093001843 dimerization interface [polypeptide binding]; other site 741093001844 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 741093001845 ureidoglycolate hydrolase; Provisional; Region: PRK03606 741093001846 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 741093001847 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 741093001848 Bacterial transcriptional regulator; Region: IclR; pfam01614 741093001849 glyoxylate carboligase; Provisional; Region: PRK11269 741093001850 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741093001851 PYR/PP interface [polypeptide binding]; other site 741093001852 dimer interface [polypeptide binding]; other site 741093001853 TPP binding site [chemical binding]; other site 741093001854 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741093001855 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 741093001856 TPP-binding site [chemical binding]; other site 741093001857 hydroxypyruvate isomerase; Provisional; Region: PRK09997 741093001858 tartronate semialdehyde reductase; Provisional; Region: PRK15059 741093001859 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741093001860 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 741093001861 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 741093001862 Na binding site [ion binding]; other site 741093001863 substrate binding site [chemical binding]; other site 741093001864 putative uracil/xanthine transporter; Provisional; Region: PRK11412 741093001865 glycerate kinase II; Provisional; Region: PRK09932 741093001866 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 741093001867 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 741093001868 Cupin domain; Region: Cupin_2; cl17218 741093001869 allantoate amidohydrolase; Region: AllC; TIGR03176 741093001870 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 741093001871 active site 741093001872 metal binding site [ion binding]; metal-binding site 741093001873 dimer interface [polypeptide binding]; other site 741093001874 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 741093001875 membrane protein FdrA; Validated; Region: PRK06091 741093001876 CoA binding domain; Region: CoA_binding; pfam02629 741093001877 CoA-ligase; Region: Ligase_CoA; pfam00549 741093001878 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 741093001879 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 741093001880 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 741093001881 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 741093001882 putative substrate binding site [chemical binding]; other site 741093001883 nucleotide binding site [chemical binding]; other site 741093001884 nucleotide binding site [chemical binding]; other site 741093001885 homodimer interface [polypeptide binding]; other site 741093001886 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 741093001887 ATP-grasp domain; Region: ATP-grasp; pfam02222 741093001888 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 741093001889 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 741093001890 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741093001891 putative active site [active] 741093001892 putative metal binding site [ion binding]; other site 741093001893 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 741093001894 substrate binding site [chemical binding]; other site 741093001895 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 741093001896 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 741093001897 active site 741093001898 HIGH motif; other site 741093001899 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 741093001900 KMSKS motif; other site 741093001901 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 741093001902 tRNA binding surface [nucleotide binding]; other site 741093001903 anticodon binding site; other site 741093001904 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 741093001905 ribosome-associated protein; Provisional; Region: PRK11507 741093001906 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 741093001907 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 741093001908 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 741093001909 homodimer interface [polypeptide binding]; other site 741093001910 NADP binding site [chemical binding]; other site 741093001911 substrate binding site [chemical binding]; other site 741093001912 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 741093001913 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 741093001914 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093001915 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093001916 outer membrane usher protein FimD; Provisional; Region: PRK15198 741093001917 PapC N-terminal domain; Region: PapC_N; pfam13954 741093001918 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093001919 PapC C-terminal domain; Region: PapC_C; pfam13953 741093001920 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 741093001921 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 741093001922 transcriptional regulator FimZ; Provisional; Region: PRK09935 741093001923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093001924 active site 741093001925 phosphorylation site [posttranslational modification] 741093001926 intermolecular recognition site; other site 741093001927 dimerization interface [polypeptide binding]; other site 741093001928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093001929 DNA binding residues [nucleotide binding] 741093001930 dimerization interface [polypeptide binding]; other site 741093001931 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741093001932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093001933 hypothetical protein; Provisional; Region: PRK09936 741093001934 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 741093001935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093001936 TPR motif; other site 741093001937 binding surface 741093001938 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 741093001939 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 741093001940 active site 741093001941 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 741093001942 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 741093001943 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 741093001944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741093001945 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093001946 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093001947 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093001948 RHS Repeat; Region: RHS_repeat; cl11982 741093001949 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093001950 PAAR motif; Region: PAAR_motif; pfam05488 741093001951 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 741093001952 RHS Repeat; Region: RHS_repeat; pfam05593 741093001953 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 741093001954 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093001955 RHS Repeat; Region: RHS_repeat; cl11982 741093001956 RHS Repeat; Region: RHS_repeat; pfam05593 741093001957 RHS Repeat; Region: RHS_repeat; cl11982 741093001958 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 741093001959 RHS Repeat; Region: RHS_repeat; cl11982 741093001960 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093001961 Uncharacterized conserved protein [Function unknown]; Region: COG5435 741093001962 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 741093001963 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741093001964 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741093001965 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741093001966 sensor kinase CusS; Provisional; Region: PRK09835 741093001967 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093001968 dimerization interface [polypeptide binding]; other site 741093001969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093001970 dimer interface [polypeptide binding]; other site 741093001971 phosphorylation site [posttranslational modification] 741093001972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093001973 ATP binding site [chemical binding]; other site 741093001974 Mg2+ binding site [ion binding]; other site 741093001975 G-X-G motif; other site 741093001976 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 741093001977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093001978 active site 741093001979 phosphorylation site [posttranslational modification] 741093001980 intermolecular recognition site; other site 741093001981 dimerization interface [polypeptide binding]; other site 741093001982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093001983 DNA binding site [nucleotide binding] 741093001984 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 741093001985 periplasmic copper-binding protein; Provisional; Region: PRK09838 741093001986 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 741093001987 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093001988 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 741093001989 phenylalanine transporter; Provisional; Region: PRK10249 741093001990 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 741093001991 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741093001992 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 741093001993 dimer interface [polypeptide binding]; other site 741093001994 FMN binding site [chemical binding]; other site 741093001995 hypothetical protein; Provisional; Region: PRK10250 741093001996 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 741093001997 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 741093001998 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 741093001999 Hok/gef family; Region: HOK_GEF; pfam01848 741093002000 Hok/gef family; Region: HOK_GEF; pfam01848 741093002001 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 741093002002 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 741093002003 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 741093002004 outer membrane receptor FepA; Provisional; Region: PRK13524 741093002005 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093002006 N-terminal plug; other site 741093002007 ligand-binding site [chemical binding]; other site 741093002008 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 741093002009 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 741093002010 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 741093002011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 741093002012 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 741093002013 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 741093002014 acyl-activating enzyme (AAE) consensus motif; other site 741093002015 AMP binding site [chemical binding]; other site 741093002016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 741093002017 LPS O-antigen length regulator; Provisional; Region: PRK10381 741093002018 Chain length determinant protein; Region: Wzz; pfam02706 741093002019 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 741093002020 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 741093002021 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741093002022 Walker A/P-loop; other site 741093002023 ATP binding site [chemical binding]; other site 741093002024 Q-loop/lid; other site 741093002025 ABC transporter signature motif; other site 741093002026 Walker B; other site 741093002027 D-loop; other site 741093002028 H-loop/switch region; other site 741093002029 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 741093002030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093002031 ABC-ATPase subunit interface; other site 741093002032 dimer interface [polypeptide binding]; other site 741093002033 putative PBP binding regions; other site 741093002034 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741093002035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093002036 ABC-ATPase subunit interface; other site 741093002037 dimer interface [polypeptide binding]; other site 741093002038 putative PBP binding regions; other site 741093002039 enterobactin exporter EntS; Provisional; Region: PRK10489 741093002040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093002041 putative substrate translocation pore; other site 741093002042 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 741093002043 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 741093002044 siderophore binding site; other site 741093002045 isochorismate synthase EntC; Provisional; Region: PRK15016 741093002046 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 741093002047 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 741093002048 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 741093002049 acyl-activating enzyme (AAE) consensus motif; other site 741093002050 active site 741093002051 AMP binding site [chemical binding]; other site 741093002052 substrate binding site [chemical binding]; other site 741093002053 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 741093002054 hydrophobic substrate binding pocket; other site 741093002055 Isochorismatase family; Region: Isochorismatase; pfam00857 741093002056 active site 741093002057 conserved cis-peptide bond; other site 741093002058 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 741093002059 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 741093002060 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 741093002061 putative NAD(P) binding site [chemical binding]; other site 741093002062 active site 741093002063 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 741093002064 CoenzymeA binding site [chemical binding]; other site 741093002065 subunit interaction site [polypeptide binding]; other site 741093002066 PHB binding site; other site 741093002067 carbon starvation protein A; Provisional; Region: PRK15015 741093002068 Carbon starvation protein CstA; Region: CstA; pfam02554 741093002069 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 741093002070 Uncharacterized small protein [Function unknown]; Region: COG2879 741093002071 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 741093002072 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 741093002073 putative active site [active] 741093002074 metal binding site [ion binding]; metal-binding site 741093002075 methionine aminotransferase; Validated; Region: PRK09082 741093002076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093002078 homodimer interface [polypeptide binding]; other site 741093002079 catalytic residue [active] 741093002080 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 741093002081 ParB-like nuclease domain; Region: ParBc; pfam02195 741093002082 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 741093002083 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 741093002084 Active Sites [active] 741093002085 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 741093002086 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 741093002087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093002088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093002089 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 741093002090 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 741093002091 dimerization domain [polypeptide binding]; other site 741093002092 dimer interface [polypeptide binding]; other site 741093002093 catalytic residues [active] 741093002094 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 741093002095 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 741093002096 dimer interface [polypeptide binding]; other site 741093002097 decamer (pentamer of dimers) interface [polypeptide binding]; other site 741093002098 catalytic triad [active] 741093002099 peroxidatic and resolving cysteines [active] 741093002100 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 741093002101 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 741093002102 catalytic residue [active] 741093002103 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 741093002104 catalytic residues [active] 741093002105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093002106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093002107 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093002108 Ligand Binding Site [chemical binding]; other site 741093002109 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 741093002110 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093002111 NAD binding site [chemical binding]; other site 741093002112 catalytic Zn binding site [ion binding]; other site 741093002113 structural Zn binding site [ion binding]; other site 741093002114 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 741093002115 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 741093002116 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 741093002117 B1 nucleotide binding pocket [chemical binding]; other site 741093002118 B2 nucleotide binding pocket [chemical binding]; other site 741093002119 CAS motifs; other site 741093002120 active site 741093002121 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741093002122 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 741093002123 transmembrane helices; other site 741093002124 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 741093002125 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 741093002126 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 741093002127 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 741093002128 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 741093002129 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 741093002130 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 741093002131 putative active site [active] 741093002132 (T/H)XGH motif; other site 741093002133 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 741093002134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093002135 putative active site [active] 741093002136 heme pocket [chemical binding]; other site 741093002137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093002138 ATP binding site [chemical binding]; other site 741093002139 Mg2+ binding site [ion binding]; other site 741093002140 G-X-G motif; other site 741093002141 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 741093002142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093002143 active site 741093002144 phosphorylation site [posttranslational modification] 741093002145 intermolecular recognition site; other site 741093002146 dimerization interface [polypeptide binding]; other site 741093002147 Transcriptional regulator; Region: CitT; pfam12431 741093002148 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 741093002149 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 741093002150 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 741093002151 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741093002152 DNA-binding site [nucleotide binding]; DNA binding site 741093002153 RNA-binding motif; other site 741093002154 chromosome condensation membrane protein; Provisional; Region: PRK14196 741093002155 Predicted amidohydrolase [General function prediction only]; Region: COG0388 741093002156 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 741093002157 putative active site [active] 741093002158 catalytic triad [active] 741093002159 putative dimer interface [polypeptide binding]; other site 741093002160 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 741093002161 lipoyl synthase; Provisional; Region: PRK05481 741093002162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093002163 FeS/SAM binding site; other site 741093002164 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 741093002165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093002166 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 741093002167 substrate binding pocket [chemical binding]; other site 741093002168 dimerization interface [polypeptide binding]; other site 741093002169 lipoate-protein ligase B; Provisional; Region: PRK14342 741093002170 hypothetical protein; Provisional; Region: PRK04998 741093002171 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 741093002172 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 741093002173 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 741093002174 rare lipoprotein A; Provisional; Region: PRK10672 741093002175 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 741093002176 Sporulation related domain; Region: SPOR; pfam05036 741093002177 cell wall shape-determining protein; Provisional; Region: PRK10794 741093002178 penicillin-binding protein 2; Provisional; Region: PRK10795 741093002179 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 741093002180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 741093002181 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 741093002182 ribosome-associated protein; Provisional; Region: PRK11538 741093002183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741093002184 catalytic core [active] 741093002185 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 741093002186 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 741093002187 active site 741093002188 (T/H)XGH motif; other site 741093002189 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 741093002190 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 741093002191 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 741093002192 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 741093002193 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 741093002194 HIGH motif; other site 741093002195 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 741093002196 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 741093002197 active site 741093002198 KMSKS motif; other site 741093002199 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 741093002200 tRNA binding surface [nucleotide binding]; other site 741093002201 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 741093002202 hypothetical protein; Provisional; Region: PRK11032 741093002203 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 741093002204 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741093002205 Sel1-like repeats; Region: SEL1; smart00671 741093002206 Sel1-like repeats; Region: SEL1; smart00671 741093002207 Sel1-like repeats; Region: SEL1; smart00671 741093002208 Sel1-like repeats; Region: SEL1; smart00671 741093002209 Sel1-like repeats; Region: SEL1; smart00671 741093002210 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 741093002211 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 741093002212 HSP70 interaction site [polypeptide binding]; other site 741093002213 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741093002214 Sel1-like repeats; Region: SEL1; smart00671 741093002215 Sel1-like repeats; Region: SEL1; smart00671 741093002216 Sel1-like repeats; Region: SEL1; smart00671 741093002217 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 741093002218 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 741093002219 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 741093002220 nucleotide binding site [chemical binding]; other site 741093002221 putative NEF/HSP70 interaction site [polypeptide binding]; other site 741093002222 SBD interface [polypeptide binding]; other site 741093002223 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 741093002224 active site 741093002225 tetramer interface [polypeptide binding]; other site 741093002226 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741093002227 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741093002228 Walker A/P-loop; other site 741093002229 ATP binding site [chemical binding]; other site 741093002230 Q-loop/lid; other site 741093002231 ABC transporter signature motif; other site 741093002232 Walker B; other site 741093002233 D-loop; other site 741093002234 H-loop/switch region; other site 741093002235 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002237 dimer interface [polypeptide binding]; other site 741093002238 conserved gate region; other site 741093002239 putative PBP binding loops; other site 741093002240 ABC-ATPase subunit interface; other site 741093002241 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002243 dimer interface [polypeptide binding]; other site 741093002244 conserved gate region; other site 741093002245 putative PBP binding loops; other site 741093002246 ABC-ATPase subunit interface; other site 741093002247 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 741093002248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093002249 substrate binding pocket [chemical binding]; other site 741093002250 membrane-bound complex binding site; other site 741093002251 hinge residues; other site 741093002252 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 741093002253 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 741093002254 putative active site [active] 741093002255 catalytic triad [active] 741093002256 putative dimer interface [polypeptide binding]; other site 741093002257 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 741093002258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741093002259 Transporter associated domain; Region: CorC_HlyC; smart01091 741093002260 metal-binding heat shock protein; Provisional; Region: PRK00016 741093002261 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 741093002262 PhoH-like protein; Region: PhoH; pfam02562 741093002263 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 741093002264 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 741093002265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093002266 FeS/SAM binding site; other site 741093002267 TRAM domain; Region: TRAM; pfam01938 741093002268 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 741093002269 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741093002270 asparagine synthetase B; Provisional; Region: asnB; PRK09431 741093002271 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 741093002272 active site 741093002273 dimer interface [polypeptide binding]; other site 741093002274 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 741093002275 Ligand Binding Site [chemical binding]; other site 741093002276 Molecular Tunnel; other site 741093002277 UMP phosphatase; Provisional; Region: PRK10444 741093002278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002279 active site 741093002280 motif I; other site 741093002281 motif II; other site 741093002282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002283 MarR family; Region: MarR; pfam01047 741093002284 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741093002285 ROK family; Region: ROK; pfam00480 741093002286 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 741093002287 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 741093002288 active site 741093002289 dimer interface [polypeptide binding]; other site 741093002290 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 741093002291 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 741093002292 active site 741093002293 trimer interface [polypeptide binding]; other site 741093002294 allosteric site; other site 741093002295 active site lid [active] 741093002296 hexamer (dimer of trimers) interface [polypeptide binding]; other site 741093002297 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 741093002298 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741093002299 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093002300 active site turn [active] 741093002301 phosphorylation site [posttranslational modification] 741093002302 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 741093002303 HPr interaction site; other site 741093002304 glycerol kinase (GK) interaction site [polypeptide binding]; other site 741093002305 active site 741093002306 phosphorylation site [posttranslational modification] 741093002307 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 741093002308 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 741093002309 active site 741093002310 HIGH motif; other site 741093002311 nucleotide binding site [chemical binding]; other site 741093002312 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 741093002313 KMSKS motif; other site 741093002314 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 741093002315 outer membrane porin, OprD family; Region: OprD; pfam03573 741093002316 YbfN-like lipoprotein; Region: YbfN; pfam13982 741093002317 ferric uptake regulator; Provisional; Region: fur; PRK09462 741093002318 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 741093002319 metal binding site 2 [ion binding]; metal-binding site 741093002320 putative DNA binding helix; other site 741093002321 metal binding site 1 [ion binding]; metal-binding site 741093002322 dimer interface [polypeptide binding]; other site 741093002323 structural Zn2+ binding site [ion binding]; other site 741093002324 flavodoxin FldA; Validated; Region: PRK09267 741093002325 LexA regulated protein; Provisional; Region: PRK11675 741093002326 acyl-CoA esterase; Provisional; Region: PRK10673 741093002327 PGAP1-like protein; Region: PGAP1; pfam07819 741093002328 replication initiation regulator SeqA; Provisional; Region: PRK11187 741093002329 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 741093002330 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 741093002331 active site 741093002332 substrate binding site [chemical binding]; other site 741093002333 metal binding site [ion binding]; metal-binding site 741093002334 putrescine transporter; Provisional; Region: potE; PRK10655 741093002335 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 741093002336 ornithine decarboxylase; Provisional; Region: PRK13578 741093002337 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741093002338 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741093002339 homodimer interface [polypeptide binding]; other site 741093002340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093002341 catalytic residue [active] 741093002342 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741093002343 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 741093002344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093002345 active site 741093002346 phosphorylation site [posttranslational modification] 741093002347 intermolecular recognition site; other site 741093002348 dimerization interface [polypeptide binding]; other site 741093002349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093002350 DNA binding site [nucleotide binding] 741093002351 sensor protein KdpD; Provisional; Region: PRK10490 741093002352 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 741093002353 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 741093002354 Ligand Binding Site [chemical binding]; other site 741093002355 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 741093002356 GAF domain; Region: GAF_3; pfam13492 741093002357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093002358 dimer interface [polypeptide binding]; other site 741093002359 phosphorylation site [posttranslational modification] 741093002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093002361 ATP binding site [chemical binding]; other site 741093002362 Mg2+ binding site [ion binding]; other site 741093002363 G-X-G motif; other site 741093002364 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 741093002365 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 741093002366 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741093002367 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 741093002368 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 741093002369 PAAR motif; Region: PAAR_motif; cl15808 741093002370 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093002371 RHS Repeat; Region: RHS_repeat; pfam05593 741093002372 RHS Repeat; Region: RHS_repeat; pfam05593 741093002373 RHS Repeat; Region: RHS_repeat; pfam05593 741093002374 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093002375 RHS Repeat; Region: RHS_repeat; pfam05593 741093002376 RHS Repeat; Region: RHS_repeat; pfam05593 741093002377 RHS protein; Region: RHS; pfam03527 741093002378 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093002379 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 741093002380 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741093002381 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093002382 Transposase [DNA replication, recombination, and repair]; Region: COG5433 741093002383 hypothetical protein; Provisional; Region: PRK10167 741093002384 Uncharacterized conserved protein [Function unknown]; Region: COG3272 741093002385 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 741093002386 DNA photolyase; Region: DNA_photolyase; pfam00875 741093002387 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 741093002388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093002389 putative substrate translocation pore; other site 741093002390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093002391 Uncharacterized conserved protein [Function unknown]; Region: COG0327 741093002392 metal-binding protein; Provisional; Region: PRK10799 741093002393 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 741093002394 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 741093002395 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 741093002396 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 741093002397 putative active site [active] 741093002398 endonuclease VIII; Provisional; Region: PRK10445 741093002399 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 741093002400 DNA binding site [nucleotide binding] 741093002401 catalytic residue [active] 741093002402 putative catalytic residues [active] 741093002403 H2TH interface [polypeptide binding]; other site 741093002404 intercalation triad [nucleotide binding]; other site 741093002405 substrate specificity determining residue; other site 741093002406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 741093002407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 741093002408 Putative ammonia monooxygenase; Region: AmoA; pfam05145 741093002409 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 741093002410 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 741093002411 Fimbrial protein; Region: Fimbrial; pfam00419 741093002412 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741093002413 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093002414 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093002415 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741093002416 PapC N-terminal domain; Region: PapC_N; pfam13954 741093002417 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093002418 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093002419 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 741093002420 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 741093002421 dimer interface [polypeptide binding]; other site 741093002422 active site 741093002423 citrylCoA binding site [chemical binding]; other site 741093002424 NADH binding [chemical binding]; other site 741093002425 cationic pore residues; other site 741093002426 oxalacetate/citrate binding site [chemical binding]; other site 741093002427 coenzyme A binding site [chemical binding]; other site 741093002428 catalytic triad [active] 741093002429 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 741093002430 Iron-sulfur protein interface; other site 741093002431 proximal quinone binding site [chemical binding]; other site 741093002432 SdhD (CybS) interface [polypeptide binding]; other site 741093002433 proximal heme binding site [chemical binding]; other site 741093002434 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 741093002435 SdhC subunit interface [polypeptide binding]; other site 741093002436 proximal heme binding site [chemical binding]; other site 741093002437 cardiolipin binding site; other site 741093002438 Iron-sulfur protein interface; other site 741093002439 proximal quinone binding site [chemical binding]; other site 741093002440 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 741093002441 L-aspartate oxidase; Provisional; Region: PRK06175 741093002442 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 741093002443 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 741093002444 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 741093002445 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 741093002446 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 741093002447 TPP-binding site [chemical binding]; other site 741093002448 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 741093002449 dimer interface [polypeptide binding]; other site 741093002450 PYR/PP interface [polypeptide binding]; other site 741093002451 TPP binding site [chemical binding]; other site 741093002452 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 741093002453 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741093002454 E3 interaction surface; other site 741093002455 lipoyl attachment site [posttranslational modification]; other site 741093002456 e3 binding domain; Region: E3_binding; pfam02817 741093002457 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 741093002458 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 741093002459 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 741093002460 CoA-ligase; Region: Ligase_CoA; pfam00549 741093002461 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 741093002462 CoA binding domain; Region: CoA_binding; smart00881 741093002463 CoA-ligase; Region: Ligase_CoA; pfam00549 741093002464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093002465 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741093002466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093002467 dimerization interface [polypeptide binding]; other site 741093002468 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 741093002469 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 741093002470 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 741093002471 homodimer interface [polypeptide binding]; other site 741093002472 Walker A motif; other site 741093002473 ATP binding site [chemical binding]; other site 741093002474 hydroxycobalamin binding site [chemical binding]; other site 741093002475 Walker B motif; other site 741093002476 putative fumarate hydratase; Provisional; Region: PRK15392 741093002477 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 741093002478 Fumarase C-terminus; Region: Fumerase_C; pfam05683 741093002479 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741093002480 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 741093002481 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 741093002482 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 741093002483 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 741093002484 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 741093002485 dimer interface [polypeptide binding]; other site 741093002486 active site 741093002487 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 741093002488 substrate binding site [chemical binding]; other site 741093002489 B12 cofactor binding site [chemical binding]; other site 741093002490 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 741093002491 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 741093002492 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 741093002493 conserved hypothetical protein; Region: glmL_fam; TIGR01319 741093002494 nucleotide binding site [chemical binding]; other site 741093002495 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 741093002496 B12 binding site [chemical binding]; other site 741093002497 heterodimer interface [polypeptide binding]; other site 741093002498 cobalt ligand [ion binding]; other site 741093002499 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 741093002500 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 741093002501 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 741093002502 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 741093002503 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 741093002504 hypothetical protein; Provisional; Region: PRK10588 741093002505 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 741093002506 active site 741093002507 colicin uptake protein TolQ; Provisional; Region: PRK10801 741093002508 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 741093002509 colicin uptake protein TolR; Provisional; Region: PRK11024 741093002510 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 741093002511 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 741093002512 TolA C-terminal; Region: TolA; pfam06519 741093002513 translocation protein TolB; Provisional; Region: tolB; PRK03629 741093002514 TolB amino-terminal domain; Region: TolB_N; pfam04052 741093002515 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 741093002516 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 741093002517 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 741093002518 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 741093002519 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093002520 ligand binding site [chemical binding]; other site 741093002521 tol-pal system protein YbgF; Provisional; Region: PRK10803 741093002522 Tetratricopeptide repeat; Region: TPR_6; pfam13174 741093002523 Tetratricopeptide repeat; Region: TPR_6; pfam13174 741093002524 quinolinate synthetase; Provisional; Region: PRK09375 741093002525 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 741093002526 zinc transporter ZitB; Provisional; Region: PRK03557 741093002527 YbgS-like protein; Region: YbgS; pfam13985 741093002528 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 741093002529 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741093002530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741093002531 catalytic core [active] 741093002532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741093002533 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 741093002534 active site 741093002535 catalytic residues [active] 741093002536 galactokinase; Provisional; Region: PRK05101 741093002537 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 741093002538 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 741093002539 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 741093002540 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 741093002541 dimer interface [polypeptide binding]; other site 741093002542 active site 741093002543 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 741093002544 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 741093002545 NAD binding site [chemical binding]; other site 741093002546 homodimer interface [polypeptide binding]; other site 741093002547 active site 741093002548 substrate binding site [chemical binding]; other site 741093002549 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 741093002550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 741093002551 Walker A/P-loop; other site 741093002552 ATP binding site [chemical binding]; other site 741093002553 Q-loop/lid; other site 741093002554 ABC transporter signature motif; other site 741093002555 Walker B; other site 741093002556 D-loop; other site 741093002557 H-loop/switch region; other site 741093002558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093002559 Walker A/P-loop; other site 741093002560 ATP binding site [chemical binding]; other site 741093002561 Q-loop/lid; other site 741093002562 ABC transporter signature motif; other site 741093002563 Walker B; other site 741093002564 D-loop; other site 741093002565 H-loop/switch region; other site 741093002566 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 741093002567 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 741093002568 molybdenum-pterin binding domain; Region: Mop; TIGR00638 741093002569 TOBE domain; Region: TOBE; pfam03459 741093002570 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 741093002571 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 741093002572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093002573 substrate binding pocket [chemical binding]; other site 741093002574 membrane-bound complex binding site; other site 741093002575 hinge residues; other site 741093002576 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 741093002577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002578 putative PBP binding loops; other site 741093002579 ABC-ATPase subunit interface; other site 741093002580 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 741093002581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093002582 Walker A/P-loop; other site 741093002583 ATP binding site [chemical binding]; other site 741093002584 Q-loop/lid; other site 741093002585 ABC transporter signature motif; other site 741093002586 Walker B; other site 741093002587 D-loop; other site 741093002588 H-loop/switch region; other site 741093002589 molybdenum-pterin binding domain; Region: Mop; TIGR00638 741093002590 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 741093002591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002592 motif II; other site 741093002593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002594 6-phosphogluconolactonase; Provisional; Region: PRK11028 741093002595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093002596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093002597 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 741093002598 putative dimerization interface [polypeptide binding]; other site 741093002599 PrpF protein; Region: PrpF; pfam04303 741093002600 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741093002601 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 741093002602 transmembrane helices; other site 741093002603 putative hydratase; Provisional; Region: PRK11413 741093002604 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 741093002605 substrate binding site [chemical binding]; other site 741093002606 ligand binding site [chemical binding]; other site 741093002607 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 741093002608 substrate binding site [chemical binding]; other site 741093002609 acyl-CoA thioesterase; Provisional; Region: PRK10531 741093002610 putative pectinesterase; Region: PLN02432; cl01911 741093002611 Excisionase-like protein; Region: Exc; pfam07825 741093002612 DksA-like zinc finger domain containing protein; Region: PHA00080 741093002613 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 741093002614 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 741093002615 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 741093002616 RecT family; Region: RecT; cl04285 741093002617 NINE Protein; Region: NinE; pfam05322 741093002618 NinF protein; Region: NinF; pfam05810 741093002619 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 741093002620 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 741093002621 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741093002622 active site 741093002623 metal binding site [ion binding]; metal-binding site 741093002624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 741093002625 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 741093002626 Lysis protein S; Region: Lysis_S; pfam04971 741093002627 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093002628 catalytic residues [active] 741093002629 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093002630 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 741093002631 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741093002632 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 741093002633 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093002634 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 741093002635 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741093002636 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093002637 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 741093002638 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 741093002639 oligomer interface [polypeptide binding]; other site 741093002640 active site residues [active] 741093002641 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 741093002642 Uncharacterized conserved protein [Function unknown]; Region: COG5471 741093002643 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 741093002644 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 741093002645 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 741093002646 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741093002647 Bacterial Ig-like domain 2; Region: BID_2; smart00635 741093002648 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 741093002649 Minor tail protein T; Region: Phage_tail_T; pfam06223 741093002650 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093002651 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093002652 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093002653 Phage-related protein [Function unknown]; Region: COG4718 741093002654 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093002655 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093002656 MPN+ (JAMM) motif; other site 741093002657 Zinc-binding site [ion binding]; other site 741093002658 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093002659 NlpC/P60 family; Region: NLPC_P60; cl17555 741093002660 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093002661 Phage-related protein, tail component [Function unknown]; Region: COG4733 741093002662 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741093002663 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741093002664 Fibronectin type III protein; Region: DUF3672; pfam12421 741093002665 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 741093002666 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093002667 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 741093002668 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093002669 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093002670 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 741093002671 type III secretion system protein; Provisional; Region: PRK15384; cl14665 741093002672 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 741093002673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 741093002674 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 741093002675 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 741093002676 substrate binding site [chemical binding]; other site 741093002677 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 741093002678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093002679 inhibitor-cofactor binding pocket; inhibition site 741093002680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093002681 catalytic residue [active] 741093002682 biotin synthase; Provisional; Region: PRK15108 741093002683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093002684 FeS/SAM binding site; other site 741093002685 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 741093002686 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 741093002687 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 741093002688 substrate-cofactor binding pocket; other site 741093002689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093002690 catalytic residue [active] 741093002691 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 741093002692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093002693 S-adenosylmethionine binding site [chemical binding]; other site 741093002694 AAA domain; Region: AAA_26; pfam13500 741093002695 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741093002696 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 741093002697 ADP binding site [chemical binding]; other site 741093002698 excinuclease ABC subunit B; Provisional; Region: PRK05298 741093002699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093002700 ATP binding site [chemical binding]; other site 741093002701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093002702 nucleotide binding region [chemical binding]; other site 741093002703 ATP-binding site [chemical binding]; other site 741093002704 Ultra-violet resistance protein B; Region: UvrB; pfam12344 741093002705 UvrB/uvrC motif; Region: UVR; pfam02151 741093002706 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 741093002707 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 741093002708 putative substrate binding pocket [chemical binding]; other site 741093002709 dimer interface [polypeptide binding]; other site 741093002710 phosphate binding site [ion binding]; other site 741093002711 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 741093002712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093002713 FeS/SAM binding site; other site 741093002714 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 741093002715 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 741093002716 MPT binding site; other site 741093002717 trimer interface [polypeptide binding]; other site 741093002718 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 741093002719 trimer interface [polypeptide binding]; other site 741093002720 dimer interface [polypeptide binding]; other site 741093002721 putative active site [active] 741093002722 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 741093002723 MoaE interaction surface [polypeptide binding]; other site 741093002724 MoeB interaction surface [polypeptide binding]; other site 741093002725 thiocarboxylated glycine; other site 741093002726 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 741093002727 MoaE homodimer interface [polypeptide binding]; other site 741093002728 MoaD interaction [polypeptide binding]; other site 741093002729 active site residues [active] 741093002730 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 741093002731 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 741093002732 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 741093002733 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 741093002734 Predicted integral membrane protein [Function unknown]; Region: COG0392 741093002735 cardiolipin synthase 2; Provisional; Region: PRK11263 741093002736 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 741093002737 putative active site [active] 741093002738 catalytic site [active] 741093002739 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 741093002740 putative active site [active] 741093002741 catalytic site [active] 741093002742 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 741093002743 putative catalytic site [active] 741093002744 putative metal binding site [ion binding]; other site 741093002745 putative phosphate binding site [ion binding]; other site 741093002746 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 741093002747 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741093002748 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 741093002749 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741093002750 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 741093002751 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 741093002752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741093002753 Walker A/P-loop; other site 741093002754 ATP binding site [chemical binding]; other site 741093002755 Q-loop/lid; other site 741093002756 ABC transporter signature motif; other site 741093002757 Walker B; other site 741093002758 D-loop; other site 741093002759 H-loop/switch region; other site 741093002760 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 741093002761 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741093002762 Walker A/P-loop; other site 741093002763 ATP binding site [chemical binding]; other site 741093002764 Q-loop/lid; other site 741093002765 ABC transporter signature motif; other site 741093002766 Walker B; other site 741093002767 D-loop; other site 741093002768 H-loop/switch region; other site 741093002769 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 741093002770 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093002771 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093002772 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 741093002773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093002774 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 741093002775 helicase 45; Provisional; Region: PTZ00424 741093002776 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741093002777 ATP binding site [chemical binding]; other site 741093002778 Mg++ binding site [ion binding]; other site 741093002779 motif III; other site 741093002780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093002781 nucleotide binding region [chemical binding]; other site 741093002782 ATP-binding site [chemical binding]; other site 741093002783 SopA-like central domain; Region: SopA; pfam13981 741093002784 SopA-like catalytic domain; Region: SopA_C; pfam13979 741093002785 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 741093002786 DEAD_2; Region: DEAD_2; pfam06733 741093002787 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 741093002788 glycosyl transferase family protein; Provisional; Region: PRK08136 741093002789 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 741093002790 putative dehydrogenase; Provisional; Region: PRK10098 741093002791 hypothetical protein; Provisional; Region: PRK10259 741093002792 hypothetical protein; Provisional; Region: PRK11019 741093002793 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 741093002794 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 741093002795 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093002796 N-terminal plug; other site 741093002797 ligand-binding site [chemical binding]; other site 741093002798 hypothetical protein; Provisional; Region: PRK10259 741093002799 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 741093002800 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 741093002801 putative mechanosensitive channel protein; Provisional; Region: PRK11465 741093002802 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741093002803 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 741093002804 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741093002805 Walker A/P-loop; other site 741093002806 ATP binding site [chemical binding]; other site 741093002807 Q-loop/lid; other site 741093002808 ABC transporter signature motif; other site 741093002809 Walker B; other site 741093002810 D-loop; other site 741093002811 H-loop/switch region; other site 741093002812 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093002813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002814 dimer interface [polypeptide binding]; other site 741093002815 conserved gate region; other site 741093002816 putative PBP binding loops; other site 741093002817 ABC-ATPase subunit interface; other site 741093002818 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 741093002819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093002820 substrate binding pocket [chemical binding]; other site 741093002821 membrane-bound complex binding site; other site 741093002822 hinge residues; other site 741093002823 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 741093002824 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 741093002825 dimerization interface [polypeptide binding]; other site 741093002826 DPS ferroxidase diiron center [ion binding]; other site 741093002827 ion pore; other site 741093002828 threonine and homoserine efflux system; Provisional; Region: PRK10532 741093002829 EamA-like transporter family; Region: EamA; pfam00892 741093002830 outer membrane protein X; Provisional; Region: ompX; PRK09408 741093002831 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 741093002832 Sulfatase; Region: Sulfatase; pfam00884 741093002833 manganese transport regulator MntR; Provisional; Region: PRK11050 741093002834 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 741093002835 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 741093002836 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741093002837 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 741093002838 transmembrane helices; other site 741093002839 L,D-transpeptidase; Provisional; Region: PRK10260 741093002840 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093002841 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 741093002842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093002843 Walker A/P-loop; other site 741093002844 ATP binding site [chemical binding]; other site 741093002845 Q-loop/lid; other site 741093002846 ABC transporter signature motif; other site 741093002847 Walker B; other site 741093002848 D-loop; other site 741093002849 H-loop/switch region; other site 741093002850 ABC transporter; Region: ABC_tran_2; pfam12848 741093002851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741093002852 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 741093002853 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 741093002854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002855 active site 741093002856 motif I; other site 741093002857 motif II; other site 741093002858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002859 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 741093002860 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 741093002861 active site 741093002862 intersubunit interactions; other site 741093002863 catalytic residue [active] 741093002864 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 741093002865 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 741093002866 ATP binding site [chemical binding]; other site 741093002867 substrate interface [chemical binding]; other site 741093002868 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 741093002869 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 741093002870 dimer interface [polypeptide binding]; other site 741093002871 putative functional site; other site 741093002872 putative MPT binding site; other site 741093002873 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 741093002874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093002875 Walker A/P-loop; other site 741093002876 ATP binding site [chemical binding]; other site 741093002877 Q-loop/lid; other site 741093002878 ABC transporter signature motif; other site 741093002879 Walker B; other site 741093002880 D-loop; other site 741093002881 H-loop/switch region; other site 741093002882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741093002883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093002884 Walker A/P-loop; other site 741093002885 ATP binding site [chemical binding]; other site 741093002886 Q-loop/lid; other site 741093002887 ABC transporter signature motif; other site 741093002888 Walker B; other site 741093002889 D-loop; other site 741093002890 H-loop/switch region; other site 741093002891 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741093002892 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 741093002893 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 741093002894 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 741093002895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002896 dimer interface [polypeptide binding]; other site 741093002897 conserved gate region; other site 741093002898 putative PBP binding loops; other site 741093002899 ABC-ATPase subunit interface; other site 741093002900 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 741093002901 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741093002902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002903 dimer interface [polypeptide binding]; other site 741093002904 conserved gate region; other site 741093002905 putative PBP binding loops; other site 741093002906 ABC-ATPase subunit interface; other site 741093002907 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093002908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093002909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093002910 metal binding site [ion binding]; metal-binding site 741093002911 active site 741093002912 I-site; other site 741093002913 Predicted transcriptional regulator [Transcription]; Region: COG2944 741093002914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093002915 non-specific DNA binding site [nucleotide binding]; other site 741093002916 salt bridge; other site 741093002917 sequence-specific DNA binding site [nucleotide binding]; other site 741093002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 741093002919 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 741093002920 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 741093002921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093002922 FeS/SAM binding site; other site 741093002923 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 741093002924 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 741093002925 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 741093002926 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741093002927 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 741093002928 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 741093002929 N-terminal domain interface [polypeptide binding]; other site 741093002930 dimer interface [polypeptide binding]; other site 741093002931 substrate binding pocket (H-site) [chemical binding]; other site 741093002932 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 741093002933 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 741093002934 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 741093002935 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 741093002936 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741093002937 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093002938 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 741093002939 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741093002940 active site 741093002941 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 741093002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093002943 putative substrate translocation pore; other site 741093002944 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 741093002945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002946 active site 741093002947 motif I; other site 741093002948 motif II; other site 741093002949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093002950 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741093002951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093002952 putative substrate translocation pore; other site 741093002953 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093002954 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 741093002955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093002956 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 741093002957 putative transporter; Provisional; Region: PRK04972 741093002958 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 741093002959 TrkA-C domain; Region: TrkA_C; pfam02080 741093002960 TrkA-C domain; Region: TrkA_C; pfam02080 741093002961 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 741093002962 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 741093002963 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 741093002964 GSH binding site [chemical binding]; other site 741093002965 catalytic residues [active] 741093002966 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 741093002967 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 741093002968 dimer interface [polypeptide binding]; other site 741093002969 FMN binding site [chemical binding]; other site 741093002970 NADPH bind site [chemical binding]; other site 741093002971 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 741093002972 RimK-like ATP-grasp domain; Region: RimK; pfam08443 741093002973 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 741093002974 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 741093002975 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 741093002976 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 741093002977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093002978 Walker A/P-loop; other site 741093002979 ATP binding site [chemical binding]; other site 741093002980 Q-loop/lid; other site 741093002981 ABC transporter signature motif; other site 741093002982 Walker B; other site 741093002983 D-loop; other site 741093002984 H-loop/switch region; other site 741093002985 TOBE domain; Region: TOBE_2; pfam08402 741093002986 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741093002987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002988 dimer interface [polypeptide binding]; other site 741093002989 conserved gate region; other site 741093002990 putative PBP binding loops; other site 741093002991 ABC-ATPase subunit interface; other site 741093002992 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741093002993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093002994 dimer interface [polypeptide binding]; other site 741093002995 conserved gate region; other site 741093002996 putative PBP binding loops; other site 741093002997 ABC-ATPase subunit interface; other site 741093002998 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 741093002999 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 741093003000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093003001 S-adenosylmethionine binding site [chemical binding]; other site 741093003002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 741093003003 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 741093003004 active site 741093003005 P-loop; other site 741093003006 phosphorylation site [posttranslational modification] 741093003007 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 741093003008 Sulfatase; Region: Sulfatase; cl17466 741093003009 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 741093003010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093003011 substrate binding pocket [chemical binding]; other site 741093003012 membrane-bound complex binding site; other site 741093003013 hinge residues; other site 741093003014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093003015 dimer interface [polypeptide binding]; other site 741093003016 conserved gate region; other site 741093003017 putative PBP binding loops; other site 741093003018 ABC-ATPase subunit interface; other site 741093003019 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093003020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093003021 dimer interface [polypeptide binding]; other site 741093003022 conserved gate region; other site 741093003023 putative PBP binding loops; other site 741093003024 ABC-ATPase subunit interface; other site 741093003025 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 741093003026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093003027 substrate binding pocket [chemical binding]; other site 741093003028 membrane-bound complex binding site; other site 741093003029 hinge residues; other site 741093003030 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 741093003031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093003032 Walker A/P-loop; other site 741093003033 ATP binding site [chemical binding]; other site 741093003034 Q-loop/lid; other site 741093003035 ABC transporter signature motif; other site 741093003036 Walker B; other site 741093003037 D-loop; other site 741093003038 H-loop/switch region; other site 741093003039 putative lipoprotein; Provisional; Region: PRK10533 741093003040 hypothetical protein; Provisional; Region: PRK02877 741093003041 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 741093003042 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 741093003043 amidase catalytic site [active] 741093003044 Zn binding residues [ion binding]; other site 741093003045 substrate binding site [chemical binding]; other site 741093003046 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741093003047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741093003048 NAD(P) binding site [chemical binding]; other site 741093003049 active site 741093003050 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 741093003051 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 741093003052 putative NAD(P) binding site [chemical binding]; other site 741093003053 putative active site [active] 741093003054 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 741093003055 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 741093003056 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 741093003057 tetramer interface [polypeptide binding]; other site 741093003058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093003059 catalytic residue [active] 741093003060 pyruvate dehydrogenase; Provisional; Region: PRK09124 741093003061 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 741093003062 PYR/PP interface [polypeptide binding]; other site 741093003063 dimer interface [polypeptide binding]; other site 741093003064 tetramer interface [polypeptide binding]; other site 741093003065 TPP binding site [chemical binding]; other site 741093003066 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741093003067 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 741093003068 TPP-binding site [chemical binding]; other site 741093003069 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 741093003070 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 741093003071 FAD binding pocket [chemical binding]; other site 741093003072 FAD binding motif [chemical binding]; other site 741093003073 phosphate binding motif [ion binding]; other site 741093003074 beta-alpha-beta structure motif; other site 741093003075 NAD binding pocket [chemical binding]; other site 741093003076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093003077 catalytic loop [active] 741093003078 iron binding site [ion binding]; other site 741093003079 hybrid cluster protein; Provisional; Region: PRK05290 741093003080 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093003081 ACS interaction site; other site 741093003082 CODH interaction site; other site 741093003083 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 741093003084 hybrid metal cluster; other site 741093003085 Predicted membrane protein [Function unknown]; Region: COG2431 741093003086 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 741093003087 amphipathic channel; other site 741093003088 Asn-Pro-Ala signature motifs; other site 741093003089 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 741093003090 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 741093003091 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 741093003092 putative active site [active] 741093003093 putative metal-binding site [ion binding]; other site 741093003094 Protein of unknown function (DUF535); Region: DUF535; pfam04393 741093003095 macrolide transporter subunit MacA; Provisional; Region: PRK11578 741093003096 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093003097 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093003098 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 741093003099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741093003100 Walker A/P-loop; other site 741093003101 ATP binding site [chemical binding]; other site 741093003102 Q-loop/lid; other site 741093003103 ABC transporter signature motif; other site 741093003104 Walker B; other site 741093003105 D-loop; other site 741093003106 H-loop/switch region; other site 741093003107 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741093003108 FtsX-like permease family; Region: FtsX; pfam02687 741093003109 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741093003110 DNA-binding site [nucleotide binding]; DNA binding site 741093003111 RNA-binding motif; other site 741093003112 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 741093003113 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 741093003114 Clp amino terminal domain; Region: Clp_N; pfam02861 741093003115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093003116 Walker A motif; other site 741093003117 ATP binding site [chemical binding]; other site 741093003118 Walker B motif; other site 741093003119 arginine finger; other site 741093003120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093003121 Walker A motif; other site 741093003122 ATP binding site [chemical binding]; other site 741093003123 Walker B motif; other site 741093003124 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 741093003125 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 741093003126 rRNA binding site [nucleotide binding]; other site 741093003127 predicted 30S ribosome binding site; other site 741093003128 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 741093003129 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 741093003130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093003131 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 741093003132 Walker A/P-loop; other site 741093003133 ATP binding site [chemical binding]; other site 741093003134 Q-loop/lid; other site 741093003135 ABC transporter signature motif; other site 741093003136 Walker B; other site 741093003137 D-loop; other site 741093003138 H-loop/switch region; other site 741093003139 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 741093003140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093003141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093003142 Walker A/P-loop; other site 741093003143 ATP binding site [chemical binding]; other site 741093003144 Q-loop/lid; other site 741093003145 ABC transporter signature motif; other site 741093003146 Walker B; other site 741093003147 D-loop; other site 741093003148 H-loop/switch region; other site 741093003149 thioredoxin reductase; Provisional; Region: PRK10262 741093003150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093003151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093003152 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 741093003153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093003154 putative DNA binding site [nucleotide binding]; other site 741093003155 putative Zn2+ binding site [ion binding]; other site 741093003156 AsnC family; Region: AsnC_trans_reg; pfam01037 741093003157 DNA translocase FtsK; Provisional; Region: PRK10263 741093003158 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 741093003159 DNA translocase FtsK; Provisional; Region: PRK10263 741093003160 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 741093003161 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 741093003162 periplasmic chaperone LolA; Region: lolA; TIGR00547 741093003163 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 741093003164 recombination factor protein RarA; Reviewed; Region: PRK13342 741093003165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093003166 Walker A motif; other site 741093003167 ATP binding site [chemical binding]; other site 741093003168 Walker B motif; other site 741093003169 arginine finger; other site 741093003170 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 741093003171 seryl-tRNA synthetase; Provisional; Region: PRK05431 741093003172 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 741093003173 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 741093003174 dimer interface [polypeptide binding]; other site 741093003175 active site 741093003176 motif 1; other site 741093003177 motif 2; other site 741093003178 motif 3; other site 741093003179 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 741093003180 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 741093003181 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741093003182 putative [Fe4-S4] binding site [ion binding]; other site 741093003183 putative molybdopterin cofactor binding site [chemical binding]; other site 741093003184 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741093003185 putative molybdopterin cofactor binding site; other site 741093003186 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 741093003187 4Fe-4S binding domain; Region: Fer4; pfam00037 741093003188 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 741093003189 Isochorismatase family; Region: Isochorismatase; pfam00857 741093003190 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 741093003191 catalytic triad [active] 741093003192 dimer interface [polypeptide binding]; other site 741093003193 conserved cis-peptide bond; other site 741093003194 putative MFS family transporter protein; Provisional; Region: PRK03633 741093003195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093003196 putative substrate translocation pore; other site 741093003197 Amino acid permease; Region: AA_permease_2; pfam13520 741093003198 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 741093003199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093003200 FeS/SAM binding site; other site 741093003201 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 741093003202 Pyruvate formate lyase 1; Region: PFL1; cd01678 741093003203 coenzyme A binding site [chemical binding]; other site 741093003204 active site 741093003205 catalytic residues [active] 741093003206 glycine loop; other site 741093003207 formate transporter; Provisional; Region: PRK10805 741093003208 uncharacterized domain; Region: TIGR00702 741093003209 YcaO-like family; Region: YcaO; pfam02624 741093003210 Predicted membrane protein [Function unknown]; Region: COG2323 741093003211 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 741093003212 homodimer interface [polypeptide binding]; other site 741093003213 substrate-cofactor binding pocket; other site 741093003214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093003215 catalytic residue [active] 741093003216 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 741093003217 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 741093003218 hinge; other site 741093003219 active site 741093003220 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 741093003221 cytidylate kinase; Provisional; Region: cmk; PRK00023 741093003222 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 741093003223 CMP-binding site; other site 741093003224 The sites determining sugar specificity; other site 741093003225 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 741093003226 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 741093003227 RNA binding site [nucleotide binding]; other site 741093003228 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 741093003229 RNA binding site [nucleotide binding]; other site 741093003230 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 741093003231 RNA binding site [nucleotide binding]; other site 741093003232 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 741093003233 RNA binding site [nucleotide binding]; other site 741093003234 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 741093003235 RNA binding site [nucleotide binding]; other site 741093003236 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741093003237 IHF dimer interface [polypeptide binding]; other site 741093003238 IHF - DNA interface [nucleotide binding]; other site 741093003239 ComEC family competence protein; Provisional; Region: PRK11539 741093003240 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 741093003241 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 741093003242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 741093003243 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 741093003244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093003245 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 741093003246 Walker A/P-loop; other site 741093003247 ATP binding site [chemical binding]; other site 741093003248 Q-loop/lid; other site 741093003249 ABC transporter signature motif; other site 741093003250 Walker B; other site 741093003251 D-loop; other site 741093003252 H-loop/switch region; other site 741093003253 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 741093003254 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 741093003255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 741093003256 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 741093003257 hypothetical protein; Provisional; Region: PRK11827 741093003258 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 741093003259 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 741093003260 Ligand binding site; other site 741093003261 oligomer interface; other site 741093003262 hypothetical protein; Provisional; Region: PRK10593 741093003263 Uncharacterized conserved protein [Function unknown]; Region: COG1434 741093003264 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 741093003265 putative active site [active] 741093003266 Methyltransferase domain; Region: Methyltransf_31; pfam13847 741093003267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093003268 S-adenosylmethionine binding site [chemical binding]; other site 741093003269 condesin subunit F; Provisional; Region: PRK05260 741093003270 condesin subunit E; Provisional; Region: PRK05256 741093003271 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 741093003272 MukB N-terminal; Region: MukB; pfam04310 741093003273 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 741093003274 murein L,D-transpeptidase; Provisional; Region: PRK10594 741093003275 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 741093003276 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093003277 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093003278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 741093003279 Peptidase M15; Region: Peptidase_M15_3; cl01194 741093003280 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 741093003281 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 741093003282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093003283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093003284 homodimer interface [polypeptide binding]; other site 741093003285 catalytic residue [active] 741093003286 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093003287 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741093003288 trimer interface [polypeptide binding]; other site 741093003289 eyelet of channel; other site 741093003290 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 741093003291 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 741093003292 putative dimer interface [polypeptide binding]; other site 741093003293 putative anticodon binding site; other site 741093003294 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 741093003295 homodimer interface [polypeptide binding]; other site 741093003296 motif 1; other site 741093003297 motif 2; other site 741093003298 active site 741093003299 motif 3; other site 741093003300 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 741093003301 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 741093003302 active site 741093003303 aminopeptidase N; Provisional; Region: pepN; PRK14015 741093003304 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 741093003305 active site 741093003306 Zn binding site [ion binding]; other site 741093003307 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 741093003308 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741093003309 Walker A/P-loop; other site 741093003310 ATP binding site [chemical binding]; other site 741093003311 Q-loop/lid; other site 741093003312 ABC transporter signature motif; other site 741093003313 Walker B; other site 741093003314 D-loop; other site 741093003315 H-loop/switch region; other site 741093003316 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741093003317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093003318 dimer interface [polypeptide binding]; other site 741093003319 conserved gate region; other site 741093003320 putative PBP binding loops; other site 741093003321 ABC-ATPase subunit interface; other site 741093003322 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 741093003323 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 741093003324 active site 741093003325 dimer interface [polypeptide binding]; other site 741093003326 non-prolyl cis peptide bond; other site 741093003327 insertion regions; other site 741093003328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093003329 substrate binding pocket [chemical binding]; other site 741093003330 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 741093003331 membrane-bound complex binding site; other site 741093003332 hinge residues; other site 741093003333 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 741093003334 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741093003335 Fimbrial protein; Region: Fimbrial; cl01416 741093003336 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741093003337 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093003338 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093003339 Fimbrial protein; Region: Fimbrial; cl01416 741093003340 Fimbrial protein; Region: Fimbrial; cl01416 741093003341 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093003342 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093003343 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 741093003344 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 741093003345 quinone interaction residues [chemical binding]; other site 741093003346 active site 741093003347 catalytic residues [active] 741093003348 FMN binding site [chemical binding]; other site 741093003349 substrate binding site [chemical binding]; other site 741093003350 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 741093003351 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 741093003352 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 741093003353 MOSC domain; Region: MOSC; pfam03473 741093003354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093003355 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 741093003356 catalytic loop [active] 741093003357 iron binding site [ion binding]; other site 741093003358 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 741093003359 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 741093003360 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 741093003361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093003362 S-adenosylmethionine binding site [chemical binding]; other site 741093003363 ABC transporter ATPase component; Reviewed; Region: PRK11147 741093003364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093003365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093003366 Walker A/P-loop; other site 741093003367 Walker A/P-loop; other site 741093003368 ATP binding site [chemical binding]; other site 741093003369 ATP binding site [chemical binding]; other site 741093003370 Q-loop/lid; other site 741093003371 Q-loop/lid; other site 741093003372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741093003373 ABC transporter signature motif; other site 741093003374 Walker B; other site 741093003375 D-loop; other site 741093003376 ABC transporter; Region: ABC_tran_2; pfam12848 741093003377 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741093003378 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 741093003379 Paraquat-inducible protein A; Region: PqiA; pfam04403 741093003380 Paraquat-inducible protein A; Region: PqiA; pfam04403 741093003381 paraquat-inducible protein B; Provisional; Region: PRK10807 741093003382 mce related protein; Region: MCE; pfam02470 741093003383 mce related protein; Region: MCE; pfam02470 741093003384 mce related protein; Region: MCE; pfam02470 741093003385 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 741093003386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 741093003387 Protein of unknown function (DUF330); Region: DUF330; pfam03886 741093003388 ribosome modulation factor; Provisional; Region: PRK14563 741093003389 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 741093003390 active site 1 [active] 741093003391 dimer interface [polypeptide binding]; other site 741093003392 active site 2 [active] 741093003393 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 741093003394 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 741093003395 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 741093003396 outer membrane protein A; Reviewed; Region: PRK10808 741093003397 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 741093003398 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093003399 ligand binding site [chemical binding]; other site 741093003400 cell division inhibitor SulA; Region: sula; TIGR00623 741093003401 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 741093003402 TfoX C-terminal domain; Region: TfoX_C; pfam04994 741093003403 TIGR01666 family membrane protein; Region: YCCS 741093003404 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 741093003405 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741093003406 Predicted membrane protein [Function unknown]; Region: COG3304 741093003407 Domain of unknown function (DUF307); Region: DUF307; pfam03733 741093003408 Domain of unknown function (DUF307); Region: DUF307; pfam03733 741093003409 DNA helicase IV; Provisional; Region: helD; PRK11054 741093003410 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 741093003411 Part of AAA domain; Region: AAA_19; pfam13245 741093003412 Family description; Region: UvrD_C_2; pfam13538 741093003413 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 741093003414 active site 741093003415 dimer interfaces [polypeptide binding]; other site 741093003416 catalytic residues [active] 741093003417 hypothetical protein; Provisional; Region: PRK03641 741093003418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 741093003419 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 741093003420 heat shock protein HspQ; Provisional; Region: PRK14129 741093003421 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 741093003422 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 741093003423 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 741093003424 putative RNA binding site [nucleotide binding]; other site 741093003425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093003426 S-adenosylmethionine binding site [chemical binding]; other site 741093003427 Acylphosphatase; Region: Acylphosphatase; cl00551 741093003428 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 741093003429 sulfur transfer protein TusE; Provisional; Region: PRK11508 741093003430 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 741093003431 YccA-like proteins; Region: YccA_like; cd10433 741093003432 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093003433 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741093003434 dimer interface [polypeptide binding]; other site 741093003435 active site 741093003436 Int/Topo IB signature motif; other site 741093003437 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 741093003438 active site 741093003439 substrate binding site [chemical binding]; other site 741093003440 catalytic site [active] 741093003441 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741093003442 DicB protein; Region: DicB; pfam05358 741093003443 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 741093003444 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 741093003445 transcriptional repressor DicA; Reviewed; Region: PRK09706 741093003446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093003447 non-specific DNA binding site [nucleotide binding]; other site 741093003448 salt bridge; other site 741093003449 sequence-specific DNA binding site [nucleotide binding]; other site 741093003450 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741093003451 primosomal protein DnaI; Provisional; Region: PRK02854 741093003452 putative replication protein; Provisional; Region: PRK12377 741093003453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093003454 Walker A motif; other site 741093003455 ATP binding site [chemical binding]; other site 741093003456 Walker B motif; other site 741093003457 arginine finger; other site 741093003458 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 741093003459 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 741093003460 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 741093003461 Hok/gef family; Region: HOK_GEF; pfam01848 741093003462 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741093003463 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 741093003464 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 741093003465 CAAX protease self-immunity; Region: Abi; pfam02517 741093003466 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093003467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093003468 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093003469 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093003470 Transposase; Region: HTH_Tnp_1; cl17663 741093003471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003472 HTH-like domain; Region: HTH_21; pfam13276 741093003473 Integrase core domain; Region: rve; pfam00665 741093003474 Integrase core domain; Region: rve_3; pfam13683 741093003475 PerC transcriptional activator; Region: PerC; pfam06069 741093003476 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093003477 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093003478 catalytic residues [active] 741093003479 Lysis protein S; Region: Lysis_S; pfam04971 741093003480 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 741093003481 Transposase; Region: HTH_Tnp_1; pfam01527 741093003482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003484 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093003485 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093003486 homodimer interface [polypeptide binding]; other site 741093003487 putative GKAP docking site [polypeptide binding]; other site 741093003488 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093003489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003490 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093003491 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093003492 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093003493 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741093003494 gpW; Region: gpW; pfam02831 741093003495 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741093003496 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093003497 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 741093003498 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 741093003499 tandem repeat interface [polypeptide binding]; other site 741093003500 oligomer interface [polypeptide binding]; other site 741093003501 active site residues [active] 741093003502 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 741093003503 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 741093003504 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741093003505 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 741093003506 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 741093003507 Minor tail protein T; Region: Phage_tail_T; cl05636 741093003508 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093003509 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093003510 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093003511 Phage-related protein [Function unknown]; Region: COG4718 741093003512 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093003513 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093003514 MPN+ (JAMM) motif; other site 741093003515 Zinc-binding site [ion binding]; other site 741093003516 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093003517 NlpC/P60 family; Region: NLPC_P60; cl17555 741093003518 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093003519 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 741093003520 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 741093003521 E-class dimer interface [polypeptide binding]; other site 741093003522 P-class dimer interface [polypeptide binding]; other site 741093003523 active site 741093003524 Cu2+ binding site [ion binding]; other site 741093003525 Zn2+ binding site [ion binding]; other site 741093003526 Phage-related protein, tail component [Function unknown]; Region: COG4733 741093003527 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741093003528 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 741093003529 Interdomain contacts; other site 741093003530 Cytokine receptor motif; other site 741093003531 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741093003532 Fibronectin type III protein; Region: DUF3672; pfam12421 741093003533 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 741093003534 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093003535 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093003536 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093003537 EspF protein repeat; Region: EspF; pfam04806 741093003538 EspF protein repeat; Region: EspF; pfam04806 741093003539 EspF protein repeat; Region: EspF; pfam04806 741093003540 EspF protein repeat; Region: EspF; pfam04806 741093003541 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 741093003542 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 741093003543 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 741093003544 hydrogenase 1 large subunit; Provisional; Region: PRK10170 741093003545 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 741093003546 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 741093003547 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 741093003548 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 741093003549 putative substrate-binding site; other site 741093003550 nickel binding site [ion binding]; other site 741093003551 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 741093003552 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 741093003553 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 741093003554 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 741093003555 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 741093003556 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 741093003557 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 741093003558 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 741093003559 catalytic core [active] 741093003560 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 741093003561 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 741093003562 Chain length determinant protein; Region: Wzz; pfam02706 741093003563 Chain length determinant protein; Region: Wzz; cl15801 741093003564 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 741093003565 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 741093003566 Nucleotide binding site [chemical binding]; other site 741093003567 Low molecular weight phosphatase family; Region: LMWPc; cd00115 741093003568 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 741093003569 active site 741093003570 polysaccharide export protein Wza; Provisional; Region: PRK15078 741093003571 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 741093003572 SLBB domain; Region: SLBB; pfam10531 741093003573 SLBB domain; Region: SLBB; pfam10531 741093003574 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 741093003575 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 741093003576 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 741093003577 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741093003578 DNA-binding site [nucleotide binding]; DNA binding site 741093003579 RNA-binding motif; other site 741093003580 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741093003581 DNA-binding site [nucleotide binding]; DNA binding site 741093003582 RNA-binding motif; other site 741093003583 cold shock gene; Provisional; Region: PRK09891 741093003584 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 741093003585 4Fe-4S binding domain; Region: Fer4_5; pfam12801 741093003586 4Fe-4S binding domain; Region: Fer4_5; pfam12801 741093003587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093003588 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 741093003589 HAMP domain; Region: HAMP; pfam00672 741093003590 dimerization interface [polypeptide binding]; other site 741093003591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093003592 dimer interface [polypeptide binding]; other site 741093003593 phosphorylation site [posttranslational modification] 741093003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093003595 ATP binding site [chemical binding]; other site 741093003596 Mg2+ binding site [ion binding]; other site 741093003597 G-X-G motif; other site 741093003598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093003599 active site 741093003600 phosphorylation site [posttranslational modification] 741093003601 intermolecular recognition site; other site 741093003602 dimerization interface [polypeptide binding]; other site 741093003603 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741093003604 putative binding surface; other site 741093003605 active site 741093003606 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 741093003607 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 741093003608 putative ligand binding site [chemical binding]; other site 741093003609 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 741093003610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093003611 active site 741093003612 phosphorylation site [posttranslational modification] 741093003613 intermolecular recognition site; other site 741093003614 dimerization interface [polypeptide binding]; other site 741093003615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093003616 DNA binding site [nucleotide binding] 741093003617 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 741093003618 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 741093003619 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 741093003620 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 741093003621 molybdopterin cofactor binding site [chemical binding]; other site 741093003622 substrate binding site [chemical binding]; other site 741093003623 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 741093003624 molybdopterin cofactor binding site; other site 741093003625 chaperone protein TorD; Validated; Region: torD; PRK04976 741093003626 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 741093003627 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 741093003628 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 741093003629 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 741093003630 HSP70 interaction site [polypeptide binding]; other site 741093003631 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 741093003632 substrate binding site [polypeptide binding]; other site 741093003633 dimer interface [polypeptide binding]; other site 741093003634 hypothetical protein; Provisional; Region: PRK09784 741093003635 hypothetical protein; Provisional; Region: PRK09784 741093003636 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 741093003637 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 741093003638 catalytic core [active] 741093003639 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 741093003640 hypothetical protein; Provisional; Region: PRK10174 741093003641 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 741093003642 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741093003643 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 741093003644 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093003645 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 741093003646 Int/Topo IB signature motif; other site 741093003647 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 741093003648 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 741093003649 Protein of unknown function (DUF551); Region: DUF551; pfam04448 741093003650 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 741093003651 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 741093003652 DksA-like zinc finger domain containing protein; Region: PHA00080 741093003653 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 741093003654 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 741093003655 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 741093003656 phage recombination protein Bet; Region: bet_lambda; TIGR01913 741093003657 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 741093003658 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 741093003659 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 741093003660 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 741093003661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 741093003662 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 741093003663 active site 741093003664 ATP binding site [chemical binding]; other site 741093003665 substrate binding site [chemical binding]; other site 741093003666 activation loop (A-loop); other site 741093003667 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 741093003668 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 741093003669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093003670 non-specific DNA binding site [nucleotide binding]; other site 741093003671 salt bridge; other site 741093003672 sequence-specific DNA binding site [nucleotide binding]; other site 741093003673 Predicted transcriptional regulator [Transcription]; Region: COG2932 741093003674 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093003675 Catalytic site [active] 741093003676 Helix-turn-helix domain; Region: HTH_17; pfam12728 741093003677 Bacteriophage CII protein; Region: Phage_CII; pfam05269 741093003678 Helix-turn-helix domain; Region: HTH_36; pfam13730 741093003679 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 741093003680 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 741093003681 active site 741093003682 metal binding site [ion binding]; metal-binding site 741093003683 interdomain interaction site; other site 741093003684 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 741093003685 thioester formation/cholesterol transfer; other site 741093003686 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 741093003687 ATP binding site [chemical binding]; other site 741093003688 AAA domain; Region: AAA_25; pfam13481 741093003689 Walker B motif; other site 741093003690 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 741093003691 NinB protein; Region: NinB; pfam05772 741093003692 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 741093003693 NINE Protein; Region: NinE; pfam05322 741093003694 ORF6N domain; Region: ORF6N; pfam10543 741093003695 Phage anti-repressor protein [Transcription]; Region: COG3561 741093003696 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 741093003697 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 741093003698 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 741093003699 Phage NinH protein; Region: Phage_NinH; pfam06322 741093003700 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 741093003701 DNA methylase; Region: N6_N4_Mtase; cl17433 741093003702 Ribosome inactivating protein; Region: RIP; pfam00161 741093003703 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 741093003704 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093003705 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093003706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 741093003707 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 741093003708 Protein of unknown function (DUF826); Region: DUF826; pfam05696 741093003709 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093003710 catalytic residues [active] 741093003711 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 741093003712 ORF11CD3 domain; Region: ORF11CD3; pfam10549 741093003713 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093003714 Bor protein; Region: Lambda_Bor; pfam06291 741093003715 large terminase protein; Provisional; Region: 17; PHA02533 741093003716 large terminase protein; Provisional; Region: 17; PHA02533 741093003717 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 741093003718 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093003719 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 741093003720 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 741093003721 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093003722 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093003723 Phage-related protein, tail component [Function unknown]; Region: COG4733 741093003724 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741093003725 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 741093003726 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 741093003727 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 741093003728 Hok/gef family; Region: HOK_GEF; pfam01848 741093003729 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 741093003730 Protein of unknown function (DUF551); Region: DUF551; pfam04448 741093003731 DksA-like zinc finger domain containing protein; Region: PHA00080 741093003732 Phage anti-repressor protein [Transcription]; Region: COG3561 741093003733 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 741093003734 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 741093003735 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 741093003736 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 741093003737 putative FMN binding site [chemical binding]; other site 741093003738 pyrimidine utilization protein D; Region: RutD; TIGR03611 741093003739 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 741093003740 homotrimer interaction site [polypeptide binding]; other site 741093003741 putative active site [active] 741093003742 Isochorismatase family; Region: Isochorismatase; pfam00857 741093003743 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 741093003744 catalytic triad [active] 741093003745 conserved cis-peptide bond; other site 741093003746 pyrimidine utilization protein A; Region: RutA; TIGR03612 741093003747 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 741093003748 active site 741093003749 dimer interface [polypeptide binding]; other site 741093003750 non-prolyl cis peptide bond; other site 741093003751 insertion regions; other site 741093003752 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 741093003753 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 741093003754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093003755 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 741093003756 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 741093003757 Predicted transcriptional regulator [Transcription]; Region: COG3905 741093003758 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 741093003759 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 741093003760 Glutamate binding site [chemical binding]; other site 741093003761 NAD binding site [chemical binding]; other site 741093003762 catalytic residues [active] 741093003763 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 741093003764 Na binding site [ion binding]; other site 741093003765 FTR1 family protein; Region: TIGR00145 741093003766 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 741093003767 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 741093003768 Imelysin; Region: Peptidase_M75; pfam09375 741093003769 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 741093003770 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 741093003771 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 741093003772 hypothetical protein; Provisional; Region: PRK10536 741093003773 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 741093003774 N-glycosyltransferase; Provisional; Region: PRK11204 741093003775 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 741093003776 DXD motif; other site 741093003777 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 741093003778 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 741093003779 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 741093003780 putative active site [active] 741093003781 putative metal binding site [ion binding]; other site 741093003782 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 741093003783 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093003784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093003785 metal binding site [ion binding]; metal-binding site 741093003786 active site 741093003787 I-site; other site 741093003788 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741093003789 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093003790 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 741093003791 DNA binding site [nucleotide binding] 741093003792 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 741093003793 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 741093003794 NADP binding site [chemical binding]; other site 741093003795 homodimer interface [polypeptide binding]; other site 741093003796 active site 741093003797 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741093003798 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093003799 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093003800 Fimbrial protein; Region: Fimbrial; cl01416 741093003801 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741093003802 PapC N-terminal domain; Region: PapC_N; pfam13954 741093003803 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093003804 PapC C-terminal domain; Region: PapC_C; pfam13953 741093003805 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741093003806 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093003807 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093003808 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093003809 haemagglutination activity domain; Region: Haemagg_act; pfam05860 741093003810 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 741093003811 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 741093003812 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 741093003813 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 741093003814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 741093003815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741093003816 NAD(P) binding site [chemical binding]; other site 741093003817 active site 741093003818 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 741093003819 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 741093003820 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 741093003821 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 741093003822 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 741093003823 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741093003824 dimer interface [polypeptide binding]; other site 741093003825 active site 741093003826 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 741093003827 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 741093003828 active site 741093003829 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 741093003830 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 741093003831 active site 741093003832 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 741093003833 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741093003834 Walker A/P-loop; other site 741093003835 ATP binding site [chemical binding]; other site 741093003836 Q-loop/lid; other site 741093003837 ABC transporter signature motif; other site 741093003838 Walker B; other site 741093003839 D-loop; other site 741093003840 H-loop/switch region; other site 741093003841 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 741093003842 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741093003843 FtsX-like permease family; Region: FtsX; pfam02687 741093003844 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 741093003845 integrase; Provisional; Region: PRK09692 741093003846 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093003847 active site 741093003848 Int/Topo IB signature motif; other site 741093003849 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 741093003850 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 741093003851 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 741093003852 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 741093003853 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 741093003854 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 741093003855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 741093003856 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 741093003857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093003858 ATP binding site [chemical binding]; other site 741093003859 putative Mg++ binding site [ion binding]; other site 741093003860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093003861 nucleotide binding region [chemical binding]; other site 741093003862 ATP-binding site [chemical binding]; other site 741093003863 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093003864 homodimer interface [polypeptide binding]; other site 741093003865 putative GKAP docking site [polypeptide binding]; other site 741093003866 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093003867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003868 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093003869 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093003870 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093003871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003872 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093003873 Transposase; Region: HTH_Tnp_1; pfam01527 741093003874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003875 putative transposase OrfB; Reviewed; Region: PHA02517 741093003876 Integrase core domain; Region: rve; pfam00665 741093003877 Integrase core domain; Region: rve_3; pfam13683 741093003878 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 741093003879 potential frameshift: common BLAST hit: gi|218691194|ref|YP_002399406.1| putative Restriction enzyme subunit beta 741093003880 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 741093003881 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741093003882 Sulfatase; Region: Sulfatase; pfam00884 741093003883 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 741093003884 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 741093003885 alpha-gamma subunit interface [polypeptide binding]; other site 741093003886 beta-gamma subunit interface [polypeptide binding]; other site 741093003887 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 741093003888 gamma-beta subunit interface [polypeptide binding]; other site 741093003889 alpha-beta subunit interface [polypeptide binding]; other site 741093003890 urease subunit alpha; Reviewed; Region: ureC; PRK13207 741093003891 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 741093003892 subunit interactions [polypeptide binding]; other site 741093003893 active site 741093003894 flap region; other site 741093003895 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 741093003896 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 741093003897 dimer interface [polypeptide binding]; other site 741093003898 catalytic residues [active] 741093003899 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 741093003900 UreF; Region: UreF; pfam01730 741093003901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741093003902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003903 Transposase; Region: HTH_Tnp_1; pfam01527 741093003904 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 741093003905 Hok/gef family; Region: HOK_GEF; pfam01848 741093003906 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093003907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003908 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093003909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003910 Transposase; Region: HTH_Tnp_1; pfam01527 741093003911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003912 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093003913 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093003914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003915 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093003916 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093003917 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093003918 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093003919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003920 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093003921 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093003922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093003923 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093003924 Predicted transcriptional regulator [Transcription]; Region: COG2378 741093003925 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 741093003926 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 741093003927 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 741093003928 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 741093003929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093003930 active site 741093003931 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 741093003932 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 741093003933 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 741093003934 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 741093003935 putative metal binding site [ion binding]; other site 741093003936 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 741093003937 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 741093003938 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 741093003939 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 741093003940 putative metal binding site [ion binding]; other site 741093003941 tellurite resistance protein terB; Region: terB; cd07176 741093003942 putative metal binding site [ion binding]; other site 741093003943 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 741093003944 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 741093003945 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 741093003946 putative metal binding site [ion binding]; other site 741093003947 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 741093003948 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 741093003949 putative metal binding site [ion binding]; other site 741093003950 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 741093003951 putative metal binding site [ion binding]; other site 741093003952 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 741093003953 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093003954 N-terminal plug; other site 741093003955 ligand-binding site [chemical binding]; other site 741093003956 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 741093003957 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 741093003958 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 741093003959 homodimer interface [polypeptide binding]; other site 741093003960 TDP-binding site; other site 741093003961 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 741093003962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 741093003963 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 741093003964 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 741093003965 Helix-turn-helix domain; Region: HTH_39; pfam14090 741093003966 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 741093003967 putative transposase OrfB; Reviewed; Region: PHA02517 741093003968 HTH-like domain; Region: HTH_21; pfam13276 741093003969 Integrase core domain; Region: rve; pfam00665 741093003970 Integrase core domain; Region: rve_3; pfam13683 741093003971 Transposase; Region: HTH_Tnp_1; cl17663 741093003972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003973 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 741093003974 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 741093003975 potential frameshift: common BLAST hit: gi|260854487|ref|YP_003228378.1| UvrD/REP helicase 741093003976 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 741093003977 AAA domain; Region: AAA_12; pfam13087 741093003978 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 741093003979 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 741093003980 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 741093003981 Active Sites [active] 741093003982 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 741093003983 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 741093003984 ParB-like nuclease domain; Region: ParB; smart00470 741093003985 PerC transcriptional activator; Region: PerC; pfam06069 741093003986 Helix-turn-helix domain; Region: HTH_28; pfam13518 741093003987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093003988 Transposase; Region: HTH_Tnp_1; pfam01527 741093003989 Predicted GTPase [General function prediction only]; Region: COG3596 741093003990 YfjP GTPase; Region: YfjP; cd11383 741093003991 G1 box; other site 741093003992 GTP/Mg2+ binding site [chemical binding]; other site 741093003993 Switch I region; other site 741093003994 G2 box; other site 741093003995 Switch II region; other site 741093003996 G3 box; other site 741093003997 G4 box; other site 741093003998 G5 box; other site 741093003999 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 741093004000 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 741093004001 hypothetical protein; Provisional; Region: PRK09945 741093004002 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741093004003 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093004004 Autotransporter beta-domain; Region: Autotransporter; smart00869 741093004005 hypothetical protein; Provisional; Region: PRK09866 741093004006 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 741093004007 G1 box; other site 741093004008 GTP/Mg2+ binding site [chemical binding]; other site 741093004009 G2 box; other site 741093004010 Switch I region; other site 741093004011 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 741093004012 G3 box; other site 741093004013 Switch II region; other site 741093004014 GTP/Mg2+ binding site [chemical binding]; other site 741093004015 G4 box; other site 741093004016 G5 box; other site 741093004017 YjcZ-like protein; Region: YjcZ; pfam13990 741093004018 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 741093004019 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 741093004020 nucleophile elbow; other site 741093004021 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 741093004022 Domain of unknown function (DUF932); Region: DUF932; pfam06067 741093004023 Antirestriction protein; Region: Antirestrict; pfam03230 741093004024 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 741093004025 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 741093004026 MPN+ (JAMM) motif; other site 741093004027 Zinc-binding site [ion binding]; other site 741093004028 Protein of unknown function (DUF987); Region: DUF987; pfam06174 741093004029 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 741093004030 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 741093004031 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 741093004032 Methyltransferase domain; Region: Methyltransf_27; pfam13708 741093004033 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 741093004034 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 741093004035 putative ligand binding site [chemical binding]; other site 741093004036 NAD binding site [chemical binding]; other site 741093004037 dimerization interface [polypeptide binding]; other site 741093004038 catalytic site [active] 741093004039 putative hydrolase; Validated; Region: PRK09248 741093004040 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 741093004041 active site 741093004042 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 741093004043 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 741093004044 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 741093004045 curli assembly protein CsgF; Provisional; Region: PRK10050 741093004046 curli assembly protein CsgE; Provisional; Region: PRK10386 741093004047 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 741093004048 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093004049 DNA binding residues [nucleotide binding] 741093004050 dimerization interface [polypeptide binding]; other site 741093004051 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 741093004052 Curlin associated repeat; Region: Curlin_rpt; pfam07012 741093004053 Curlin associated repeat; Region: Curlin_rpt; pfam07012 741093004054 major curlin subunit; Provisional; Region: csgA; PRK10051 741093004055 Curlin associated repeat; Region: Curlin_rpt; pfam07012 741093004056 Curlin associated repeat; Region: Curlin_rpt; pfam07012 741093004057 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 741093004058 Fimbrial protein; Region: Fimbrial; cl01416 741093004059 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 741093004060 putative ADP-ribose binding site [chemical binding]; other site 741093004061 putative active site [active] 741093004062 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 741093004063 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 741093004064 putative active site [active] 741093004065 catalytic site [active] 741093004066 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 741093004067 putative active site [active] 741093004068 catalytic site [active] 741093004069 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 741093004070 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741093004071 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 741093004072 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 741093004073 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 741093004074 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 741093004075 Ligand binding site; other site 741093004076 DXD motif; other site 741093004077 lipoprotein; Provisional; Region: PRK10175 741093004078 secY/secA suppressor protein; Provisional; Region: PRK11467 741093004079 drug efflux system protein MdtG; Provisional; Region: PRK09874 741093004080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093004081 putative substrate translocation pore; other site 741093004082 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741093004083 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741093004084 putative acyl-acceptor binding pocket; other site 741093004085 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 741093004086 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 741093004087 active site residue [active] 741093004088 hypothetical protein; Provisional; Region: PRK03757 741093004089 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 741093004090 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 741093004091 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 741093004092 hydroxyglutarate oxidase; Provisional; Region: PRK11728 741093004093 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 741093004094 DNA damage-inducible protein I; Provisional; Region: PRK10597 741093004095 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 741093004096 active site 741093004097 substrate binding pocket [chemical binding]; other site 741093004098 dimer interface [polypeptide binding]; other site 741093004099 lipoprotein; Provisional; Region: PRK10598 741093004100 glutaredoxin 2; Provisional; Region: PRK10387 741093004101 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 741093004102 C-terminal domain interface [polypeptide binding]; other site 741093004103 GSH binding site (G-site) [chemical binding]; other site 741093004104 catalytic residues [active] 741093004105 putative dimer interface [polypeptide binding]; other site 741093004106 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 741093004107 N-terminal domain interface [polypeptide binding]; other site 741093004108 multidrug resistance protein MdtH; Provisional; Region: PRK11646 741093004109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093004110 putative substrate translocation pore; other site 741093004111 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 741093004112 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 741093004113 hypothetical protein; Provisional; Region: PRK11239 741093004114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 741093004115 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741093004116 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741093004117 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741093004118 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 741093004119 MviN-like protein; Region: MVIN; pfam03023 741093004120 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 741093004121 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 741093004122 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 741093004123 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 741093004124 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 741093004125 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 741093004126 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 741093004127 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 741093004128 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741093004129 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 741093004130 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 741093004131 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 741093004132 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 741093004133 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 741093004134 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741093004135 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 741093004136 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 741093004137 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 741093004138 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741093004139 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 741093004140 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 741093004141 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741093004142 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 741093004143 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 741093004144 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 741093004145 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 741093004146 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 741093004147 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 741093004148 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 741093004149 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 741093004150 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 741093004151 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741093004152 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 741093004153 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 741093004154 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 741093004155 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 741093004156 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 741093004157 homodimer interface [polypeptide binding]; other site 741093004158 oligonucleotide binding site [chemical binding]; other site 741093004159 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 741093004160 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 741093004161 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 741093004162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093004163 RNA binding surface [nucleotide binding]; other site 741093004164 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741093004165 active site 741093004166 Maf-like protein; Region: Maf; pfam02545 741093004167 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 741093004168 active site 741093004169 dimer interface [polypeptide binding]; other site 741093004170 hypothetical protein; Provisional; Region: PRK11193 741093004171 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 741093004172 putative phosphate acyltransferase; Provisional; Region: PRK05331 741093004173 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 741093004174 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 741093004175 dimer interface [polypeptide binding]; other site 741093004176 active site 741093004177 CoA binding pocket [chemical binding]; other site 741093004178 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 741093004179 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 741093004180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 741093004181 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 741093004182 NAD(P) binding site [chemical binding]; other site 741093004183 homotetramer interface [polypeptide binding]; other site 741093004184 homodimer interface [polypeptide binding]; other site 741093004185 active site 741093004186 acyl carrier protein; Provisional; Region: acpP; PRK00982 741093004187 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 741093004188 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741093004189 dimer interface [polypeptide binding]; other site 741093004190 active site 741093004191 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 741093004192 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 741093004193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093004194 catalytic residue [active] 741093004195 conserved hypothetical protein, YceG family; Region: TIGR00247 741093004196 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 741093004197 dimerization interface [polypeptide binding]; other site 741093004198 thymidylate kinase; Validated; Region: tmk; PRK00698 741093004199 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 741093004200 TMP-binding site; other site 741093004201 ATP-binding site [chemical binding]; other site 741093004202 DNA polymerase III subunit delta'; Validated; Region: PRK07993 741093004203 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 741093004204 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 741093004205 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 741093004206 active site 741093004207 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 741093004208 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741093004209 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093004210 active site turn [active] 741093004211 phosphorylation site [posttranslational modification] 741093004212 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 741093004213 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093004214 N-terminal plug; other site 741093004215 ligand-binding site [chemical binding]; other site 741093004216 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 741093004217 nucleotide binding site/active site [active] 741093004218 HIT family signature motif; other site 741093004219 catalytic residue [active] 741093004220 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 741093004221 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 741093004222 putative dimer interface [polypeptide binding]; other site 741093004223 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 741093004224 thiamine kinase; Region: ycfN_thiK; TIGR02721 741093004225 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 741093004226 active site 741093004227 substrate binding site [chemical binding]; other site 741093004228 ATP binding site [chemical binding]; other site 741093004229 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 741093004230 beta-hexosaminidase; Provisional; Region: PRK05337 741093004231 hypothetical protein; Provisional; Region: PRK04940 741093004232 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 741093004233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093004234 hypothetical protein; Provisional; Region: PRK11280 741093004235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741093004236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093004237 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093004238 L,D-transpeptidase; Provisional; Region: PRK10260 741093004239 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093004240 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093004241 transcription-repair coupling factor; Provisional; Region: PRK10689 741093004242 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 741093004243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093004244 ATP binding site [chemical binding]; other site 741093004245 putative Mg++ binding site [ion binding]; other site 741093004246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093004247 nucleotide binding region [chemical binding]; other site 741093004248 ATP-binding site [chemical binding]; other site 741093004249 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 741093004250 Predicted membrane protein [Function unknown]; Region: COG4763 741093004251 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741093004252 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 741093004253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741093004254 FtsX-like permease family; Region: FtsX; pfam02687 741093004255 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 741093004256 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741093004257 Walker A/P-loop; other site 741093004258 ATP binding site [chemical binding]; other site 741093004259 Q-loop/lid; other site 741093004260 ABC transporter signature motif; other site 741093004261 Walker B; other site 741093004262 D-loop; other site 741093004263 H-loop/switch region; other site 741093004264 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 741093004265 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741093004266 FtsX-like permease family; Region: FtsX; pfam02687 741093004267 fructokinase; Reviewed; Region: PRK09557 741093004268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093004269 nucleotide binding site [chemical binding]; other site 741093004270 NAD-dependent deacetylase; Provisional; Region: PRK00481 741093004271 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 741093004272 NAD+ binding site [chemical binding]; other site 741093004273 substrate binding site [chemical binding]; other site 741093004274 Zn binding site [ion binding]; other site 741093004275 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 741093004276 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 741093004277 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741093004278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093004279 dimer interface [polypeptide binding]; other site 741093004280 conserved gate region; other site 741093004281 putative PBP binding loops; other site 741093004282 ABC-ATPase subunit interface; other site 741093004283 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 741093004284 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093004285 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741093004286 dimer interface [polypeptide binding]; other site 741093004287 active site 741093004288 Int/Topo IB signature motif; other site 741093004289 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 741093004290 active site 741093004291 substrate binding site [chemical binding]; other site 741093004292 catalytic site [active] 741093004293 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 741093004294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093004295 sequence-specific DNA binding site [nucleotide binding]; other site 741093004296 salt bridge; other site 741093004297 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741093004298 Pyocin large subunit [General function prediction only]; Region: COG5529 741093004299 primosomal protein DnaI; Provisional; Region: PRK02854 741093004300 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 741093004301 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 741093004302 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 741093004303 Protein of unknown function (DUF551); Region: DUF551; pfam04448 741093004304 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741093004305 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 741093004306 Antitermination protein; Region: Antiterm; pfam03589 741093004307 Antitermination protein; Region: Antiterm; pfam03589 741093004308 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093004309 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093004310 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 741093004311 Protein of unknown function (DUF826); Region: DUF826; pfam05696 741093004312 Lysis protein S; Region: Lysis_S; pfam04971 741093004313 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093004314 catalytic residues [active] 741093004315 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 741093004316 ORF11CD3 domain; Region: ORF11CD3; pfam10549 741093004317 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093004318 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 741093004319 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741093004320 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093004321 active site 741093004322 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 741093004323 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 741093004324 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 741093004325 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 741093004326 Phage capsid family; Region: Phage_capsid; pfam05065 741093004327 Phage-related protein [Function unknown]; Region: COG4695 741093004328 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 741093004329 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 741093004330 oligomerization interface [polypeptide binding]; other site 741093004331 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 741093004332 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 741093004333 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 741093004334 Immunoglobulin I-set domain; Region: I-set; pfam07679 741093004335 Immunoglobulin domain; Region: Ig_2; pfam13895 741093004336 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 741093004337 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 741093004338 Phage-related protein [Function unknown]; Region: COG4718 741093004339 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093004340 Mnt; Region: mnt; PHA01513 741093004341 Arc-like DNA binding domain; Region: Arc; pfam03869 741093004342 Prophage antirepressor [Transcription]; Region: COG3617 741093004343 BRO family, N-terminal domain; Region: Bro-N; smart01040 741093004344 Phage anti-repressor protein [Transcription]; Region: COG3561 741093004345 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093004346 MPN+ (JAMM) motif; other site 741093004347 Zinc-binding site [ion binding]; other site 741093004348 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093004349 NlpC/P60 family; Region: NLPC_P60; cl17555 741093004350 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093004351 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 741093004352 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093004353 SopA-like central domain; Region: SopA; pfam13981 741093004354 SopA-like catalytic domain; Region: SopA_C; pfam13979 741093004355 IS2 transposase TnpB; Reviewed; Region: PRK09409 741093004356 HTH-like domain; Region: HTH_21; pfam13276 741093004357 Integrase core domain; Region: rve; pfam00665 741093004358 Integrase core domain; Region: rve_3; pfam13683 741093004359 Transposase; Region: HTH_Tnp_1; cl17663 741093004360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093004361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 741093004362 type III secretion protein GogB; Provisional; Region: PRK15386 741093004363 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741093004364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093004365 dimer interface [polypeptide binding]; other site 741093004366 conserved gate region; other site 741093004367 putative PBP binding loops; other site 741093004368 ABC-ATPase subunit interface; other site 741093004369 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 741093004370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093004371 Walker A/P-loop; other site 741093004372 ATP binding site [chemical binding]; other site 741093004373 Q-loop/lid; other site 741093004374 ABC transporter signature motif; other site 741093004375 Walker B; other site 741093004376 D-loop; other site 741093004377 H-loop/switch region; other site 741093004378 TOBE domain; Region: TOBE_2; pfam08402 741093004379 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 741093004380 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 741093004381 metal binding site [ion binding]; metal-binding site 741093004382 dimer interface [polypeptide binding]; other site 741093004383 Uncharacterized conserved protein [Function unknown]; Region: COG2850 741093004384 Cupin-like domain; Region: Cupin_8; pfam13621 741093004385 integrase; Provisional; Region: PRK09692 741093004386 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093004387 active site 741093004388 Int/Topo IB signature motif; other site 741093004389 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 741093004390 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 741093004391 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 741093004392 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 741093004393 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 741093004394 ssDNA binding site [nucleotide binding]; other site 741093004395 dimer interface [polypeptide binding]; other site 741093004396 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093004397 PerC transcriptional activator; Region: PerC; pfam06069 741093004398 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 741093004399 Phage capsid family; Region: Phage_capsid; pfam05065 741093004400 Phage head maturation protease [General function prediction only]; Region: COG3740 741093004401 Phage-related protein [Function unknown]; Region: COG4695 741093004402 Phage portal protein; Region: Phage_portal; pfam04860 741093004403 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 741093004404 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 741093004405 oligomerization interface [polypeptide binding]; other site 741093004406 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741093004407 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093004408 active site 741093004409 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 741093004410 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 741093004411 sensor protein PhoQ; Provisional; Region: PRK10815 741093004412 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 741093004413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 741093004414 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 741093004415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093004416 ATP binding site [chemical binding]; other site 741093004417 Mg2+ binding site [ion binding]; other site 741093004418 G-X-G motif; other site 741093004419 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 741093004420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093004421 active site 741093004422 phosphorylation site [posttranslational modification] 741093004423 intermolecular recognition site; other site 741093004424 dimerization interface [polypeptide binding]; other site 741093004425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093004426 DNA binding site [nucleotide binding] 741093004427 adenylosuccinate lyase; Provisional; Region: PRK09285 741093004428 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 741093004429 tetramer interface [polypeptide binding]; other site 741093004430 active site 741093004431 putative lysogenization regulator; Reviewed; Region: PRK00218 741093004432 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 741093004433 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 741093004434 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 741093004435 nudix motif; other site 741093004436 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 741093004437 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 741093004438 probable active site [active] 741093004439 isocitrate dehydrogenase; Validated; Region: PRK07362 741093004440 isocitrate dehydrogenase; Reviewed; Region: PRK07006 741093004441 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 741093004442 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093004443 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741093004444 dimer interface [polypeptide binding]; other site 741093004445 active site 741093004446 Int/Topo IB signature motif; other site 741093004447 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 741093004448 Replication protein P; Region: Phage_lambda_P; pfam06992 741093004449 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 741093004450 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 741093004451 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 741093004452 catalytic residues [active] 741093004453 catalytic nucleophile [active] 741093004454 Recombinase; Region: Recombinase; pfam07508 741093004455 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 741093004456 hypothetical protein; Provisional; Region: PRK09741 741093004457 prophage protein NinE; Provisional; Region: PRK09689 741093004458 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 741093004459 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 741093004460 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 741093004461 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 741093004462 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093004463 catalytic residue [active] 741093004464 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093004465 Bor protein; Region: Lambda_Bor; pfam06291 741093004466 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 741093004467 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 741093004468 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 741093004469 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741093004470 gpW; Region: gpW; pfam02831 741093004471 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741093004472 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093004473 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 741093004474 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 741093004475 tandem repeat interface [polypeptide binding]; other site 741093004476 oligomer interface [polypeptide binding]; other site 741093004477 active site residues [active] 741093004478 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 741093004479 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 741093004480 DNA packaging protein FI; Region: Packaging_FI; pfam14000 741093004481 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 741093004482 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 741093004483 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 741093004484 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741093004485 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 741093004486 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 741093004487 Minor tail protein T; Region: Phage_tail_T; pfam06223 741093004488 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093004489 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093004490 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093004491 Phage-related protein [Function unknown]; Region: COG4718 741093004492 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093004493 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093004494 MPN+ (JAMM) motif; other site 741093004495 Zinc-binding site [ion binding]; other site 741093004496 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093004497 NlpC/P60 family; Region: NLPC_P60; cl17555 741093004498 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093004499 Phage-related protein, tail component [Function unknown]; Region: COG4733 741093004500 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741093004501 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741093004502 Fibronectin type III protein; Region: DUF3672; pfam12421 741093004503 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 741093004504 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093004505 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 741093004506 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 741093004507 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 741093004508 Phage Tail Collar Domain; Region: Collar; pfam07484 741093004509 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741093004510 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 741093004511 dimanganese center [ion binding]; other site 741093004512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 741093004513 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 741093004514 dimerization interface [polypeptide binding]; other site 741093004515 metal binding site [ion binding]; metal-binding site 741093004516 General stress protein [General function prediction only]; Region: GsiB; COG3729 741093004517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 741093004518 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741093004519 Transposase; Region: HTH_Tnp_1; pfam01527 741093004520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093004521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093004522 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093004523 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093004524 homodimer interface [polypeptide binding]; other site 741093004525 putative GKAP docking site [polypeptide binding]; other site 741093004526 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093004527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093004528 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093004529 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093004530 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093004531 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 741093004532 TAP-like protein; Region: Abhydrolase_4; pfam08386 741093004533 outer membrane protease; Reviewed; Region: PRK10993 741093004534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741093004535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093004536 sequence-specific DNA binding site [nucleotide binding]; other site 741093004537 salt bridge; other site 741093004538 putative transposase OrfB; Reviewed; Region: PHA02517 741093004539 HTH-like domain; Region: HTH_21; pfam13276 741093004540 Integrase core domain; Region: rve; pfam00665 741093004541 Integrase core domain; Region: rve_3; pfam13683 741093004542 Autotransporter beta-domain; Region: Autotransporter; smart00869 741093004543 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 741093004544 cell division inhibitor MinD; Provisional; Region: PRK10818 741093004545 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 741093004546 Switch I; other site 741093004547 Switch II; other site 741093004548 septum formation inhibitor; Reviewed; Region: minC; PRK03511 741093004549 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 741093004550 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 741093004551 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 741093004552 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 741093004553 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 741093004554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 741093004555 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 741093004556 hypothetical protein; Provisional; Region: PRK10691 741093004557 hypothetical protein; Provisional; Region: PRK05170 741093004558 hemolysin E; Provisional; Region: hlyE; PRK11376 741093004559 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741093004560 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093004561 Catalytic site [active] 741093004562 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 741093004563 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 741093004564 active site 741093004565 DNA binding site [nucleotide binding] 741093004566 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 741093004567 disulfide bond formation protein B; Provisional; Region: PRK01749 741093004568 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 741093004569 transmembrane helices; other site 741093004570 fatty acid metabolism regulator; Provisional; Region: PRK04984 741093004571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093004572 DNA-binding site [nucleotide binding]; DNA binding site 741093004573 FadR C-terminal domain; Region: FadR_C; pfam07840 741093004574 SpoVR family protein; Provisional; Region: PRK11767 741093004575 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 741093004576 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 741093004577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093004578 alanine racemase; Reviewed; Region: dadX; PRK03646 741093004579 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 741093004580 active site 741093004581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741093004582 substrate binding site [chemical binding]; other site 741093004583 catalytic residues [active] 741093004584 dimer interface [polypeptide binding]; other site 741093004585 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 741093004586 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 741093004587 TrkA-C domain; Region: TrkA_C; pfam02080 741093004588 Transporter associated domain; Region: CorC_HlyC; smart01091 741093004589 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 741093004590 dimer interface [polypeptide binding]; other site 741093004591 catalytic triad [active] 741093004592 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 741093004593 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093004594 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093004595 catalytic residue [active] 741093004596 putative transposase OrfB; Reviewed; Region: PHA02517 741093004597 HTH-like domain; Region: HTH_21; pfam13276 741093004598 Integrase core domain; Region: rve; pfam00665 741093004599 Integrase core domain; Region: rve_3; pfam13683 741093004600 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 741093004601 Flagellar regulator YcgR; Region: YcgR; pfam07317 741093004602 PilZ domain; Region: PilZ; pfam07238 741093004603 hypothetical protein; Provisional; Region: PRK10457 741093004604 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093004605 N-terminal plug; other site 741093004606 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 741093004607 ligand-binding site [chemical binding]; other site 741093004608 molybdenum transport protein ModD; Provisional; Region: PRK06096 741093004609 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 741093004610 dimerization interface [polypeptide binding]; other site 741093004611 active site 741093004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093004613 S-adenosylmethionine binding site [chemical binding]; other site 741093004614 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 741093004615 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741093004616 Walker A/P-loop; other site 741093004617 ATP binding site [chemical binding]; other site 741093004618 Q-loop/lid; other site 741093004619 ABC transporter signature motif; other site 741093004620 Walker B; other site 741093004621 D-loop; other site 741093004622 H-loop/switch region; other site 741093004623 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741093004624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093004625 ABC-ATPase subunit interface; other site 741093004626 dimer interface [polypeptide binding]; other site 741093004627 putative PBP binding regions; other site 741093004628 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 741093004629 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 741093004630 putative metal binding site [ion binding]; other site 741093004631 trehalase; Provisional; Region: treA; PRK13271 741093004632 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 741093004633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 741093004634 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 741093004635 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093004636 dimerization domain swap beta strand [polypeptide binding]; other site 741093004637 regulatory protein interface [polypeptide binding]; other site 741093004638 active site 741093004639 regulatory phosphorylation site [posttranslational modification]; other site 741093004640 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741093004641 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741093004642 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 741093004643 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 741093004644 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 741093004645 Dak1 domain; Region: Dak1; pfam02733 741093004646 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 741093004647 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 741093004648 GTP-binding protein YchF; Reviewed; Region: PRK09601 741093004649 YchF GTPase; Region: YchF; cd01900 741093004650 G1 box; other site 741093004651 GTP/Mg2+ binding site [chemical binding]; other site 741093004652 Switch I region; other site 741093004653 G2 box; other site 741093004654 Switch II region; other site 741093004655 G3 box; other site 741093004656 G4 box; other site 741093004657 G5 box; other site 741093004658 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 741093004659 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 741093004660 putative active site [active] 741093004661 catalytic residue [active] 741093004662 hypothetical protein; Provisional; Region: PRK10692 741093004663 putative transporter; Provisional; Region: PRK11660 741093004664 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 741093004665 Sulfate transporter family; Region: Sulfate_transp; pfam00916 741093004666 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 741093004667 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 741093004668 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 741093004669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093004670 active site 741093004671 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 741093004672 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 741093004673 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 741093004674 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 741093004675 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 741093004676 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 741093004677 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 741093004678 tRNA; other site 741093004679 putative tRNA binding site [nucleotide binding]; other site 741093004680 putative NADP binding site [chemical binding]; other site 741093004681 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 741093004682 peptide chain release factor 1; Validated; Region: prfA; PRK00591 741093004683 This domain is found in peptide chain release factors; Region: PCRF; smart00937 741093004684 RF-1 domain; Region: RF-1; pfam00472 741093004685 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 741093004686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093004687 hypothetical protein; Provisional; Region: PRK10278 741093004688 hypothetical protein; Provisional; Region: PRK10941 741093004689 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 741093004690 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 741093004691 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741093004692 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 741093004693 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 741093004694 cation transport regulator; Reviewed; Region: chaB; PRK09582 741093004695 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 741093004696 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 741093004697 putative active site pocket [active] 741093004698 dimerization interface [polypeptide binding]; other site 741093004699 putative catalytic residue [active] 741093004700 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 741093004701 putative invasin; Provisional; Region: PRK10177 741093004702 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 741093004703 transcriptional regulator NarL; Provisional; Region: PRK10651 741093004704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093004705 active site 741093004706 phosphorylation site [posttranslational modification] 741093004707 intermolecular recognition site; other site 741093004708 dimerization interface [polypeptide binding]; other site 741093004709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093004710 DNA binding residues [nucleotide binding] 741093004711 dimerization interface [polypeptide binding]; other site 741093004712 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 741093004713 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 741093004714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093004715 dimerization interface [polypeptide binding]; other site 741093004716 Histidine kinase; Region: HisKA_3; pfam07730 741093004717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093004718 ATP binding site [chemical binding]; other site 741093004719 Mg2+ binding site [ion binding]; other site 741093004720 G-X-G motif; other site 741093004721 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 741093004722 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 741093004723 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 741093004724 [4Fe-4S] binding site [ion binding]; other site 741093004725 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741093004726 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741093004727 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741093004728 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 741093004729 molybdopterin cofactor binding site; other site 741093004730 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 741093004731 4Fe-4S binding domain; Region: Fer4; cl02805 741093004732 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 741093004733 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 741093004734 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 741093004735 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 741093004736 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 741093004737 putative active site [active] 741093004738 putative substrate binding site [chemical binding]; other site 741093004739 putative cosubstrate binding site; other site 741093004740 catalytic site [active] 741093004741 SEC-C motif; Region: SEC-C; pfam02810 741093004742 hypothetical protein; Provisional; Region: PRK04233 741093004743 hypothetical protein; Provisional; Region: PRK10279 741093004744 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 741093004745 active site 741093004746 nucleophile elbow; other site 741093004747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093004748 active site 741093004749 response regulator of RpoS; Provisional; Region: PRK10693 741093004750 phosphorylation site [posttranslational modification] 741093004751 intermolecular recognition site; other site 741093004752 dimerization interface [polypeptide binding]; other site 741093004753 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 741093004754 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 741093004755 active site 741093004756 tetramer interface; other site 741093004757 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 741093004758 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 741093004759 thymidine kinase; Provisional; Region: PRK04296 741093004760 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 741093004761 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 741093004762 putative catalytic cysteine [active] 741093004763 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 741093004764 putative active site [active] 741093004765 metal binding site [ion binding]; metal-binding site 741093004766 hypothetical protein; Provisional; Region: PRK11111 741093004767 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 741093004768 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 741093004769 peptide binding site [polypeptide binding]; other site 741093004770 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 741093004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093004772 dimer interface [polypeptide binding]; other site 741093004773 conserved gate region; other site 741093004774 putative PBP binding loops; other site 741093004775 ABC-ATPase subunit interface; other site 741093004776 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 741093004777 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741093004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093004779 dimer interface [polypeptide binding]; other site 741093004780 conserved gate region; other site 741093004781 putative PBP binding loops; other site 741093004782 ABC-ATPase subunit interface; other site 741093004783 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 741093004784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093004785 Walker A/P-loop; other site 741093004786 ATP binding site [chemical binding]; other site 741093004787 Q-loop/lid; other site 741093004788 ABC transporter signature motif; other site 741093004789 Walker B; other site 741093004790 D-loop; other site 741093004791 H-loop/switch region; other site 741093004792 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741093004793 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 741093004794 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093004795 Walker A/P-loop; other site 741093004796 ATP binding site [chemical binding]; other site 741093004797 Q-loop/lid; other site 741093004798 ABC transporter signature motif; other site 741093004799 Walker B; other site 741093004800 D-loop; other site 741093004801 H-loop/switch region; other site 741093004802 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741093004803 dsDNA-mimic protein; Reviewed; Region: PRK05094 741093004804 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 741093004805 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 741093004806 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 741093004807 putative active site [active] 741093004808 catalytic site [active] 741093004809 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 741093004810 putative active site [active] 741093004811 catalytic site [active] 741093004812 voltage-gated potassium channel; Provisional; Region: PRK10537 741093004813 Ion channel; Region: Ion_trans_2; pfam07885 741093004814 TrkA-N domain; Region: TrkA_N; pfam02254 741093004815 YciI-like protein; Reviewed; Region: PRK11370 741093004816 transport protein TonB; Provisional; Region: PRK10819 741093004817 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 741093004818 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 741093004819 intracellular septation protein A; Reviewed; Region: PRK00259 741093004820 hypothetical protein; Provisional; Region: PRK02868 741093004821 outer membrane protein W; Provisional; Region: PRK10959 741093004822 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 741093004823 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093004824 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741093004825 dimer interface [polypeptide binding]; other site 741093004826 active site 741093004827 Int/Topo IB signature motif; other site 741093004828 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 741093004829 active site 741093004830 catalytic site [active] 741093004831 substrate binding site [chemical binding]; other site 741093004832 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741093004833 DicB protein; Region: DicB; pfam05358 741093004834 transcriptional repressor DicA; Reviewed; Region: PRK09706 741093004835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093004836 sequence-specific DNA binding site [nucleotide binding]; other site 741093004837 salt bridge; other site 741093004838 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 741093004839 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741093004840 Pyocin large subunit [General function prediction only]; Region: COG5529 741093004841 Helix-turn-helix domain; Region: HTH_36; pfam13730 741093004842 primosomal protein DnaI; Provisional; Region: PRK02854 741093004843 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 741093004844 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 741093004845 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741093004846 Hok/gef family; Region: HOK_GEF; pfam01848 741093004847 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741093004848 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 741093004849 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 741093004850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093004851 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741093004852 DNA methylase; Region: N6_N4_Mtase; pfam01555 741093004853 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741093004854 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093004855 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093004856 Lysis protein S; Region: Lysis_S; pfam04971 741093004857 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 741093004858 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093004859 catalytic residues [active] 741093004860 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 741093004861 ORF11CD3 domain; Region: ORF11CD3; pfam10549 741093004862 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093004863 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 741093004864 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741093004865 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093004866 active site 741093004867 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 741093004868 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 741093004869 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 741093004870 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 741093004871 Phage capsid family; Region: Phage_capsid; pfam05065 741093004872 Phage-related protein [Function unknown]; Region: COG4695 741093004873 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 741093004874 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 741093004875 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 741093004876 zinc binding site [ion binding]; other site 741093004877 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 741093004878 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 741093004879 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 741093004880 Immunoglobulin I-set domain; Region: I-set; pfam07679 741093004881 Immunoglobulin domain; Region: Ig_2; pfam13895 741093004882 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 741093004883 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 741093004884 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093004885 tape measure domain; Region: tape_meas_nterm; TIGR02675 741093004886 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 741093004887 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093004888 Phage-related protein [Function unknown]; Region: COG4718 741093004889 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093004890 Phage-related protein, tail component [Function unknown]; Region: COG4733 741093004891 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741093004892 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741093004893 Fibronectin type III protein; Region: DUF3672; pfam12421 741093004894 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 741093004895 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093004896 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093004897 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093004898 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093004899 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093004900 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741093004901 dimer interface [polypeptide binding]; other site 741093004902 active site 741093004903 Int/Topo IB signature motif; other site 741093004904 hypothetical protein; Provisional; Region: PHA03031 741093004905 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093004906 homodimer interface [polypeptide binding]; other site 741093004907 putative GKAP docking site [polypeptide binding]; other site 741093004908 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093004909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093004910 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093004911 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093004912 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093004913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093004914 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093004915 Transposase; Region: HTH_Tnp_1; pfam01527 741093004916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093004917 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093004918 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 741093004919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 741093004920 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 741093004921 dimerization interface [polypeptide binding]; other site 741093004922 metal binding site [ion binding]; metal-binding site 741093004923 General stress protein [General function prediction only]; Region: GsiB; COG3729 741093004924 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 741093004925 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 741093004926 substrate binding site [chemical binding]; other site 741093004927 active site 741093004928 catalytic residues [active] 741093004929 heterodimer interface [polypeptide binding]; other site 741093004930 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 741093004931 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 741093004932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093004933 catalytic residue [active] 741093004934 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 741093004935 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 741093004936 active site 741093004937 ribulose/triose binding site [chemical binding]; other site 741093004938 phosphate binding site [ion binding]; other site 741093004939 substrate (anthranilate) binding pocket [chemical binding]; other site 741093004940 product (indole) binding pocket [chemical binding]; other site 741093004941 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 741093004942 active site 741093004943 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 741093004944 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 741093004945 glutamine binding [chemical binding]; other site 741093004946 catalytic triad [active] 741093004947 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 741093004948 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 741093004949 anthranilate synthase component I; Provisional; Region: PRK13564 741093004950 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 741093004951 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 741093004952 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 741093004953 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 741093004954 active site 741093004955 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 741093004956 hypothetical protein; Provisional; Region: PRK11630 741093004957 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 741093004958 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 741093004959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093004960 RNA binding surface [nucleotide binding]; other site 741093004961 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 741093004962 probable active site [active] 741093004963 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 741093004964 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 741093004965 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 741093004966 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 741093004967 NADP binding site [chemical binding]; other site 741093004968 homodimer interface [polypeptide binding]; other site 741093004969 active site 741093004970 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 741093004971 putative inner membrane peptidase; Provisional; Region: PRK11778 741093004972 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 741093004973 tandem repeat interface [polypeptide binding]; other site 741093004974 oligomer interface [polypeptide binding]; other site 741093004975 active site residues [active] 741093004976 hypothetical protein; Provisional; Region: PRK11037 741093004977 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 741093004978 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 741093004979 active site 741093004980 interdomain interaction site; other site 741093004981 putative metal-binding site [ion binding]; other site 741093004982 nucleotide binding site [chemical binding]; other site 741093004983 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 741093004984 domain I; other site 741093004985 DNA binding groove [nucleotide binding] 741093004986 phosphate binding site [ion binding]; other site 741093004987 domain II; other site 741093004988 domain III; other site 741093004989 nucleotide binding site [chemical binding]; other site 741093004990 catalytic site [active] 741093004991 domain IV; other site 741093004992 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741093004993 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741093004994 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 741093004995 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 741093004996 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 741093004997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093004998 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 741093004999 substrate binding site [chemical binding]; other site 741093005000 putative dimerization interface [polypeptide binding]; other site 741093005001 aconitate hydratase; Validated; Region: PRK09277 741093005002 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 741093005003 substrate binding site [chemical binding]; other site 741093005004 ligand binding site [chemical binding]; other site 741093005005 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 741093005006 substrate binding site [chemical binding]; other site 741093005007 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 741093005008 dimerization interface [polypeptide binding]; other site 741093005009 active site 741093005010 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741093005011 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 741093005012 active site 741093005013 Predicted membrane protein [Function unknown]; Region: COG3771 741093005014 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 741093005015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 741093005016 TPR motif; other site 741093005017 binding surface 741093005018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093005019 binding surface 741093005020 TPR motif; other site 741093005021 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 741093005022 active site 741093005023 dimer interface [polypeptide binding]; other site 741093005024 translation initiation factor Sui1; Validated; Region: PRK06824 741093005025 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 741093005026 putative rRNA binding site [nucleotide binding]; other site 741093005027 lipoprotein; Provisional; Region: PRK10540 741093005028 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741093005029 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741093005030 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093005031 hypothetical protein; Provisional; Region: PRK13658 741093005032 RNase II stability modulator; Provisional; Region: PRK10060 741093005033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093005034 putative active site [active] 741093005035 heme pocket [chemical binding]; other site 741093005036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093005037 metal binding site [ion binding]; metal-binding site 741093005038 active site 741093005039 I-site; other site 741093005040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093005041 exoribonuclease II; Provisional; Region: PRK05054 741093005042 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 741093005043 RNB domain; Region: RNB; pfam00773 741093005044 S1 RNA binding domain; Region: S1; pfam00575 741093005045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 741093005046 Uncharacterized conserved protein [Function unknown]; Region: COG2128 741093005047 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 741093005048 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 741093005049 NAD binding site [chemical binding]; other site 741093005050 homotetramer interface [polypeptide binding]; other site 741093005051 homodimer interface [polypeptide binding]; other site 741093005052 substrate binding site [chemical binding]; other site 741093005053 active site 741093005054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741093005055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093005056 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 741093005057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093005058 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093005059 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 741093005060 Protein export membrane protein; Region: SecD_SecF; cl14618 741093005061 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 741093005062 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 741093005063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093005064 putative substrate translocation pore; other site 741093005065 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 741093005066 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093005067 Walker A/P-loop; other site 741093005068 ATP binding site [chemical binding]; other site 741093005069 Q-loop/lid; other site 741093005070 ABC transporter signature motif; other site 741093005071 Walker B; other site 741093005072 D-loop; other site 741093005073 H-loop/switch region; other site 741093005074 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 741093005075 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093005076 Walker A/P-loop; other site 741093005077 ATP binding site [chemical binding]; other site 741093005078 Q-loop/lid; other site 741093005079 ABC transporter signature motif; other site 741093005080 Walker B; other site 741093005081 D-loop; other site 741093005082 H-loop/switch region; other site 741093005083 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741093005084 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 741093005085 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741093005086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005087 dimer interface [polypeptide binding]; other site 741093005088 conserved gate region; other site 741093005089 putative PBP binding loops; other site 741093005090 ABC-ATPase subunit interface; other site 741093005091 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 741093005092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005093 dimer interface [polypeptide binding]; other site 741093005094 conserved gate region; other site 741093005095 putative PBP binding loops; other site 741093005096 ABC-ATPase subunit interface; other site 741093005097 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 741093005098 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 741093005099 peptide binding site [polypeptide binding]; other site 741093005100 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 741093005101 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 741093005102 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 741093005103 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 741093005104 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 741093005105 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 741093005106 catalytic triad [active] 741093005107 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 741093005108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093005109 non-specific DNA binding site [nucleotide binding]; other site 741093005110 salt bridge; other site 741093005111 sequence-specific DNA binding site [nucleotide binding]; other site 741093005112 Cupin domain; Region: Cupin_2; pfam07883 741093005113 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 741093005114 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 741093005115 NAD(P) binding site [chemical binding]; other site 741093005116 catalytic residues [active] 741093005117 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 741093005118 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 741093005119 4-aminobutyrate transaminase; Provisional; Region: PRK09792 741093005120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093005121 inhibitor-cofactor binding pocket; inhibition site 741093005122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093005123 catalytic residue [active] 741093005124 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 741093005125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093005126 Walker A motif; other site 741093005127 ATP binding site [chemical binding]; other site 741093005128 Walker B motif; other site 741093005129 arginine finger; other site 741093005130 phage shock protein PspA; Provisional; Region: PRK10698 741093005131 phage shock protein B; Provisional; Region: pspB; PRK09458 741093005132 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 741093005133 phage shock protein C; Region: phageshock_pspC; TIGR02978 741093005134 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 741093005135 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 741093005136 active site residue [active] 741093005137 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741093005138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005139 dimer interface [polypeptide binding]; other site 741093005140 conserved gate region; other site 741093005141 putative PBP binding loops; other site 741093005142 ABC-ATPase subunit interface; other site 741093005143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741093005144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005145 dimer interface [polypeptide binding]; other site 741093005146 conserved gate region; other site 741093005147 putative PBP binding loops; other site 741093005148 ABC-ATPase subunit interface; other site 741093005149 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093005150 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 741093005151 putative NAD(P) binding site [chemical binding]; other site 741093005152 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 741093005153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741093005154 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741093005155 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741093005156 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 741093005157 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 741093005158 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 741093005159 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 741093005160 beta-phosphoglucomutase; Region: bPGM; TIGR01990 741093005161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093005162 motif II; other site 741093005163 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 741093005164 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741093005165 Walker A/P-loop; other site 741093005166 ATP binding site [chemical binding]; other site 741093005167 Q-loop/lid; other site 741093005168 ABC transporter signature motif; other site 741093005169 Walker B; other site 741093005170 D-loop; other site 741093005171 H-loop/switch region; other site 741093005172 TOBE domain; Region: TOBE_2; pfam08402 741093005173 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 741093005174 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741093005175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093005176 DNA binding site [nucleotide binding] 741093005177 domain linker motif; other site 741093005178 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 741093005179 putative dimerization interface [polypeptide binding]; other site 741093005180 putative ligand binding site [chemical binding]; other site 741093005181 Predicted ATPase [General function prediction only]; Region: COG3106 741093005182 hypothetical protein; Provisional; Region: PRK05415 741093005183 TIGR01620 family protein; Region: hyp_HI0043 741093005184 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 741093005185 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 741093005186 putative aromatic amino acid binding site; other site 741093005187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093005188 Walker A motif; other site 741093005189 ATP binding site [chemical binding]; other site 741093005190 Walker B motif; other site 741093005191 arginine finger; other site 741093005192 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 741093005193 dimer interface [polypeptide binding]; other site 741093005194 catalytic triad [active] 741093005195 peroxidatic and resolving cysteines [active] 741093005196 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 741093005197 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 741093005198 active site 741093005199 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 741093005200 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 741093005201 putative active site [active] 741093005202 Zn binding site [ion binding]; other site 741093005203 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 741093005204 NADH(P)-binding; Region: NAD_binding_10; pfam13460 741093005205 putative NAD(P) binding site [chemical binding]; other site 741093005206 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 741093005207 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741093005208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093005209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093005210 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741093005211 putative effector binding pocket; other site 741093005212 putative dimerization interface [polypeptide binding]; other site 741093005213 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 741093005214 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 741093005215 peptide binding site [polypeptide binding]; other site 741093005216 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 741093005217 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741093005218 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 741093005219 universal stress protein UspE; Provisional; Region: PRK11175 741093005220 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093005221 Ligand Binding Site [chemical binding]; other site 741093005222 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093005223 Ligand Binding Site [chemical binding]; other site 741093005224 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 741093005225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 741093005226 ligand binding site [chemical binding]; other site 741093005227 flexible hinge region; other site 741093005228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741093005229 putative switch regulator; other site 741093005230 non-specific DNA interactions [nucleotide binding]; other site 741093005231 DNA binding site [nucleotide binding] 741093005232 sequence specific DNA binding site [nucleotide binding]; other site 741093005233 putative cAMP binding site [chemical binding]; other site 741093005234 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 741093005235 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 741093005236 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741093005237 DNA binding site [nucleotide binding] 741093005238 active site 741093005239 AbgT putative transporter family; Region: ABG_transport; cl17431 741093005240 putative transposase OrfB; Reviewed; Region: PHA02517 741093005241 HTH-like domain; Region: HTH_21; pfam13276 741093005242 Integrase core domain; Region: rve; pfam00665 741093005243 Integrase core domain; Region: rve_3; pfam13683 741093005244 AbgT putative transporter family; Region: ABG_transport; cl17431 741093005245 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 741093005246 amidohydrolase; Region: amidohydrolases; TIGR01891 741093005247 putative metal binding site [ion binding]; other site 741093005248 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 741093005249 amidohydrolase; Region: amidohydrolases; TIGR01891 741093005250 putative metal binding site [ion binding]; other site 741093005251 dimer interface [polypeptide binding]; other site 741093005252 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 741093005253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093005254 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 741093005255 putative substrate binding pocket [chemical binding]; other site 741093005256 putative dimerization interface [polypeptide binding]; other site 741093005257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 741093005258 Smr domain; Region: Smr; pfam01713 741093005259 PAS domain S-box; Region: sensory_box; TIGR00229 741093005260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093005261 putative active site [active] 741093005262 heme pocket [chemical binding]; other site 741093005263 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093005264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093005265 metal binding site [ion binding]; metal-binding site 741093005266 active site 741093005267 I-site; other site 741093005268 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 741093005269 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 741093005270 Cl binding site [ion binding]; other site 741093005271 oligomer interface [polypeptide binding]; other site 741093005272 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 741093005273 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741093005274 ATP binding site [chemical binding]; other site 741093005275 Mg++ binding site [ion binding]; other site 741093005276 motif III; other site 741093005277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093005278 nucleotide binding region [chemical binding]; other site 741093005279 ATP-binding site [chemical binding]; other site 741093005280 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 741093005281 putative RNA binding site [nucleotide binding]; other site 741093005282 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 741093005283 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 741093005284 Ligand Binding Site [chemical binding]; other site 741093005285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093005286 Ligand Binding Site [chemical binding]; other site 741093005287 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093005288 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 741093005289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 741093005290 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093005291 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 741093005292 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 741093005293 dimer interface [polypeptide binding]; other site 741093005294 PYR/PP interface [polypeptide binding]; other site 741093005295 TPP binding site [chemical binding]; other site 741093005296 substrate binding site [chemical binding]; other site 741093005297 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 741093005298 Domain of unknown function; Region: EKR; smart00890 741093005299 4Fe-4S binding domain; Region: Fer4_6; pfam12837 741093005300 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093005301 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 741093005302 TPP-binding site [chemical binding]; other site 741093005303 dimer interface [polypeptide binding]; other site 741093005304 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 741093005305 Domain of unknown function (DUF333); Region: DUF333; pfam03891 741093005306 heat-inducible protein; Provisional; Region: PRK10449 741093005307 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 741093005308 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 741093005309 putative ligand binding site [chemical binding]; other site 741093005310 putative NAD binding site [chemical binding]; other site 741093005311 catalytic site [active] 741093005312 hypothetical protein; Provisional; Region: PRK10695 741093005313 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 741093005314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 741093005315 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093005316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093005317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093005318 active site 741093005319 catalytic tetrad [active] 741093005320 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 741093005321 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 741093005322 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 741093005323 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 741093005324 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 741093005325 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 741093005326 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741093005327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093005328 S-adenosylmethionine binding site [chemical binding]; other site 741093005329 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 741093005330 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741093005331 active site 741093005332 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 741093005333 active site 741093005334 catalytic residues [active] 741093005335 azoreductase; Reviewed; Region: PRK00170 741093005336 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741093005337 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 741093005338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093005339 ATP binding site [chemical binding]; other site 741093005340 putative Mg++ binding site [ion binding]; other site 741093005341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093005342 nucleotide binding region [chemical binding]; other site 741093005343 ATP-binding site [chemical binding]; other site 741093005344 Helicase associated domain (HA2); Region: HA2; pfam04408 741093005345 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 741093005346 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 741093005347 Uncharacterized conserved protein [Function unknown]; Region: COG1434 741093005348 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 741093005349 putative active site [active] 741093005350 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 741093005351 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 741093005352 NAD binding site [chemical binding]; other site 741093005353 catalytic residues [active] 741093005354 substrate binding site [chemical binding]; other site 741093005355 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 741093005356 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 741093005357 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 741093005358 cytochrome b561; Provisional; Region: PRK11513 741093005359 hypothetical protein; Provisional; Region: PRK10040 741093005360 small toxic polypeptide; Provisional; Region: PRK09738 741093005361 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 741093005362 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741093005363 dimer interface [polypeptide binding]; other site 741093005364 ligand binding site [chemical binding]; other site 741093005365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093005366 dimerization interface [polypeptide binding]; other site 741093005367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741093005368 dimer interface [polypeptide binding]; other site 741093005369 putative CheW interface [polypeptide binding]; other site 741093005370 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 741093005371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093005372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093005373 dimerization interface [polypeptide binding]; other site 741093005374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 741093005375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 741093005376 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 741093005377 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 741093005378 hypothetical protein; Provisional; Region: PRK11415 741093005379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741093005380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741093005381 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 741093005382 putative trimer interface [polypeptide binding]; other site 741093005383 putative CoA binding site [chemical binding]; other site 741093005384 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 741093005385 putative trimer interface [polypeptide binding]; other site 741093005386 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 741093005387 putative CoA binding site [chemical binding]; other site 741093005388 putative trimer interface [polypeptide binding]; other site 741093005389 putative CoA binding site [chemical binding]; other site 741093005390 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 741093005391 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 741093005392 gating phenylalanine in ion channel; other site 741093005393 tellurite resistance protein TehB; Provisional; Region: PRK11207 741093005394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093005395 S-adenosylmethionine binding site [chemical binding]; other site 741093005396 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 741093005397 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 741093005398 benzoate transporter; Region: benE; TIGR00843 741093005399 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741093005400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093005401 non-specific DNA binding site [nucleotide binding]; other site 741093005402 salt bridge; other site 741093005403 sequence-specific DNA binding site [nucleotide binding]; other site 741093005404 Cupin domain; Region: Cupin_2; pfam07883 741093005405 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741093005406 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 741093005407 Peptidase family U32; Region: Peptidase_U32; pfam01136 741093005408 Collagenase; Region: DUF3656; pfam12392 741093005409 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 741093005410 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 741093005411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093005412 sequence-specific DNA binding site [nucleotide binding]; other site 741093005413 salt bridge; other site 741093005414 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741093005415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093005416 DNA-binding site [nucleotide binding]; DNA binding site 741093005417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093005418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093005419 homodimer interface [polypeptide binding]; other site 741093005420 catalytic residue [active] 741093005421 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741093005422 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741093005423 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741093005424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093005425 Walker A/P-loop; other site 741093005426 ATP binding site [chemical binding]; other site 741093005427 Q-loop/lid; other site 741093005428 ABC transporter signature motif; other site 741093005429 Walker B; other site 741093005430 D-loop; other site 741093005431 H-loop/switch region; other site 741093005432 TOBE domain; Region: TOBE_2; pfam08402 741093005433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005434 dimer interface [polypeptide binding]; other site 741093005435 conserved gate region; other site 741093005436 putative PBP binding loops; other site 741093005437 ABC-ATPase subunit interface; other site 741093005438 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741093005439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005440 ABC-ATPase subunit interface; other site 741093005441 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 741093005442 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 741093005443 tetrameric interface [polypeptide binding]; other site 741093005444 NAD binding site [chemical binding]; other site 741093005445 catalytic residues [active] 741093005446 substrate binding site [chemical binding]; other site 741093005447 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 741093005448 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 741093005449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 741093005450 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 741093005451 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741093005452 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 741093005453 Prostaglandin dehydrogenases; Region: PGDH; cd05288 741093005454 NAD(P) binding site [chemical binding]; other site 741093005455 substrate binding site [chemical binding]; other site 741093005456 dimer interface [polypeptide binding]; other site 741093005457 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 741093005458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093005459 DNA-binding site [nucleotide binding]; DNA binding site 741093005460 FCD domain; Region: FCD; pfam07729 741093005461 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 741093005462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093005463 N-terminal plug; other site 741093005464 ligand-binding site [chemical binding]; other site 741093005465 PQQ-like domain; Region: PQQ_2; pfam13360 741093005466 L-asparagine permease; Provisional; Region: PRK15049 741093005467 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 741093005468 C-terminal domain interface [polypeptide binding]; other site 741093005469 GSH binding site (G-site) [chemical binding]; other site 741093005470 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741093005471 dimer interface [polypeptide binding]; other site 741093005472 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 741093005473 dimer interface [polypeptide binding]; other site 741093005474 N-terminal domain interface [polypeptide binding]; other site 741093005475 substrate binding pocket (H-site) [chemical binding]; other site 741093005476 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 741093005477 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741093005478 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741093005479 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741093005480 PAAR motif; Region: PAAR_motif; cl15808 741093005481 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093005482 RHS Repeat; Region: RHS_repeat; pfam05593 741093005483 RHS Repeat; Region: RHS_repeat; pfam05593 741093005484 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093005485 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 741093005486 RHS Repeat; Region: RHS_repeat; pfam05593 741093005487 RHS protein; Region: RHS; pfam03527 741093005488 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093005489 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 741093005490 active site 1 [active] 741093005491 dimer interface [polypeptide binding]; other site 741093005492 hexamer interface [polypeptide binding]; other site 741093005493 active site 2 [active] 741093005494 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 741093005495 N-acetyltransferase; Region: Acetyltransf_2; cl00949 741093005496 hypothetical protein; Provisional; Region: PRK10281 741093005497 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 741093005498 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 741093005499 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 741093005500 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 741093005501 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 741093005502 [4Fe-4S] binding site [ion binding]; other site 741093005503 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741093005504 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741093005505 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741093005506 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 741093005507 molybdopterin cofactor binding site; other site 741093005508 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 741093005509 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 741093005510 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093005511 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741093005512 trimer interface [polypeptide binding]; other site 741093005513 eyelet of channel; other site 741093005514 aromatic amino acid exporter; Provisional; Region: PRK11689 741093005515 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 741093005516 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 741093005517 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 741093005518 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 741093005519 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 741093005520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093005521 non-specific DNA binding site [nucleotide binding]; other site 741093005522 salt bridge; other site 741093005523 sequence-specific DNA binding site [nucleotide binding]; other site 741093005524 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 741093005525 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 741093005526 NAD binding site [chemical binding]; other site 741093005527 substrate binding site [chemical binding]; other site 741093005528 catalytic Zn binding site [ion binding]; other site 741093005529 tetramer interface [polypeptide binding]; other site 741093005530 structural Zn binding site [ion binding]; other site 741093005531 malate dehydrogenase; Provisional; Region: PRK13529 741093005532 Malic enzyme, N-terminal domain; Region: malic; pfam00390 741093005533 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 741093005534 NAD(P) binding site [chemical binding]; other site 741093005535 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 741093005536 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 741093005537 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 741093005538 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741093005539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093005540 Walker A/P-loop; other site 741093005541 ATP binding site [chemical binding]; other site 741093005542 Q-loop/lid; other site 741093005543 ABC transporter signature motif; other site 741093005544 Walker B; other site 741093005545 D-loop; other site 741093005546 H-loop/switch region; other site 741093005547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741093005548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 741093005549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093005550 Walker A/P-loop; other site 741093005551 ATP binding site [chemical binding]; other site 741093005552 Q-loop/lid; other site 741093005553 ABC transporter signature motif; other site 741093005554 Walker B; other site 741093005555 D-loop; other site 741093005556 H-loop/switch region; other site 741093005557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741093005558 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 741093005559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741093005560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005561 dimer interface [polypeptide binding]; other site 741093005562 conserved gate region; other site 741093005563 putative PBP binding loops; other site 741093005564 ABC-ATPase subunit interface; other site 741093005565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741093005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093005567 dimer interface [polypeptide binding]; other site 741093005568 conserved gate region; other site 741093005569 putative PBP binding loops; other site 741093005570 ABC-ATPase subunit interface; other site 741093005571 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741093005572 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741093005573 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 741093005574 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 741093005575 heme-binding site [chemical binding]; other site 741093005576 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093005577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093005578 metal binding site [ion binding]; metal-binding site 741093005579 active site 741093005580 I-site; other site 741093005581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 741093005582 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 741093005583 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 741093005584 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 741093005585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093005586 catalytic residue [active] 741093005587 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 741093005588 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 741093005589 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741093005590 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 741093005591 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741093005592 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 741093005593 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 741093005594 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 741093005595 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 741093005596 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 741093005597 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 741093005598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093005599 FeS/SAM binding site; other site 741093005600 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 741093005601 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 741093005602 Sulfatase; Region: Sulfatase; pfam00884 741093005603 transcriptional regulator YdeO; Provisional; Region: PRK09940 741093005604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093005605 putative oxidoreductase; Provisional; Region: PRK09939 741093005606 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 741093005607 putative molybdopterin cofactor binding site [chemical binding]; other site 741093005608 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 741093005609 putative molybdopterin cofactor binding site; other site 741093005610 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 741093005611 mannosyl binding site [chemical binding]; other site 741093005612 Fimbrial protein; Region: Fimbrial; pfam00419 741093005613 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093005614 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093005615 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741093005616 PapC N-terminal domain; Region: PapC_N; pfam13954 741093005617 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093005618 PapC C-terminal domain; Region: PapC_C; pfam13953 741093005619 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 741093005620 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093005621 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093005622 Fimbrial protein; Region: Fimbrial; cl01416 741093005623 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 741093005624 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741093005625 HipA-like C-terminal domain; Region: HipA_C; pfam07804 741093005626 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093005627 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741093005628 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093005629 putative lipoprotein; Provisional; Region: PRK09707 741093005630 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 741093005631 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 741093005632 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 741093005633 putative N- and C-terminal domain interface [polypeptide binding]; other site 741093005634 putative active site [active] 741093005635 putative MgATP binding site [chemical binding]; other site 741093005636 catalytic site [active] 741093005637 metal binding site [ion binding]; metal-binding site 741093005638 putative carbohydrate binding site [chemical binding]; other site 741093005639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 741093005640 transcriptional regulator LsrR; Provisional; Region: PRK15418 741093005641 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 741093005642 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 741093005643 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 741093005644 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093005645 Walker A/P-loop; other site 741093005646 ATP binding site [chemical binding]; other site 741093005647 Q-loop/lid; other site 741093005648 ABC transporter signature motif; other site 741093005649 Walker B; other site 741093005650 D-loop; other site 741093005651 H-loop/switch region; other site 741093005652 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093005653 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093005654 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093005655 TM-ABC transporter signature motif; other site 741093005656 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093005657 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093005658 TM-ABC transporter signature motif; other site 741093005659 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 741093005660 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 741093005661 ligand binding site [chemical binding]; other site 741093005662 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 741093005663 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 741093005664 putative active site; other site 741093005665 catalytic residue [active] 741093005666 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 741093005667 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 741093005668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093005669 S-adenosylmethionine binding site [chemical binding]; other site 741093005670 Predicted membrane protein [Function unknown]; Region: COG3781 741093005671 altronate oxidoreductase; Provisional; Region: PRK03643 741093005672 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741093005673 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741093005674 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093005675 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093005676 metal binding site [ion binding]; metal-binding site 741093005677 active site 741093005678 I-site; other site 741093005679 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 741093005680 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 741093005681 glutaminase; Provisional; Region: PRK00971 741093005682 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 741093005683 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 741093005684 NAD(P) binding site [chemical binding]; other site 741093005685 catalytic residues [active] 741093005686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093005687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093005688 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 741093005689 putative dimerization interface [polypeptide binding]; other site 741093005690 putative arabinose transporter; Provisional; Region: PRK03545 741093005691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093005692 putative substrate translocation pore; other site 741093005693 inner membrane protein; Provisional; Region: PRK10995 741093005694 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 741093005695 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 741093005696 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 741093005697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093005698 hypothetical protein; Provisional; Region: PRK10106 741093005699 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 741093005700 EamA-like transporter family; Region: EamA; pfam00892 741093005701 EamA-like transporter family; Region: EamA; pfam00892 741093005702 putative transporter; Provisional; Region: PRK10054 741093005703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093005704 putative substrate translocation pore; other site 741093005705 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 741093005706 active site residue [active] 741093005707 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 741093005708 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741093005709 conserved cys residue [active] 741093005710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093005711 diguanylate cyclase; Provisional; Region: PRK09894 741093005712 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 741093005713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093005714 metal binding site [ion binding]; metal-binding site 741093005715 active site 741093005716 I-site; other site 741093005717 hypothetical protein; Provisional; Region: PRK10053 741093005718 hypothetical protein; Validated; Region: PRK03657 741093005719 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 741093005720 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 741093005721 active site 741093005722 Zn binding site [ion binding]; other site 741093005723 malonic semialdehyde reductase; Provisional; Region: PRK10538 741093005724 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 741093005725 putative NAD(P) binding site [chemical binding]; other site 741093005726 homodimer interface [polypeptide binding]; other site 741093005727 homotetramer interface [polypeptide binding]; other site 741093005728 active site 741093005729 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741093005730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093005731 DNA-binding site [nucleotide binding]; DNA binding site 741093005732 FCD domain; Region: FCD; pfam07729 741093005733 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 741093005734 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 741093005735 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741093005736 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741093005737 metabolite-proton symporter; Region: 2A0106; TIGR00883 741093005738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093005739 putative substrate translocation pore; other site 741093005740 DinI-like family; Region: DinI; pfam06183 741093005741 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093005742 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093005743 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093005744 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093005745 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093005746 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 741093005747 Phage-related protein, tail component [Function unknown]; Region: COG4733 741093005748 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741093005749 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 741093005750 Interdomain contacts; other site 741093005751 Cytokine receptor motif; other site 741093005752 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741093005753 Fibronectin type III protein; Region: DUF3672; pfam12421 741093005754 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093005755 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093005756 MPN+ (JAMM) motif; other site 741093005757 Zinc-binding site [ion binding]; other site 741093005758 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093005759 NlpC/P60 family; Region: NLPC_P60; cl17555 741093005760 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093005761 Phage-related protein [Function unknown]; Region: COG4718 741093005762 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093005763 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093005764 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093005765 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093005766 Minor tail protein T; Region: Phage_tail_T; cl05636 741093005767 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 741093005768 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741093005769 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 741093005770 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 741093005771 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 741093005772 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 741093005773 DNA packaging protein FI; Region: Packaging_FI; pfam14000 741093005774 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 741093005775 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 741093005776 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 741093005777 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 741093005778 tandem repeat interface [polypeptide binding]; other site 741093005779 oligomer interface [polypeptide binding]; other site 741093005780 active site residues [active] 741093005781 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741093005782 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093005783 gpW; Region: gpW; pfam02831 741093005784 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741093005785 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 741093005786 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 741093005787 PerC transcriptional activator; Region: PerC; pfam06069 741093005788 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093005789 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 741093005790 ORF11CD3 domain; Region: ORF11CD3; pfam10549 741093005791 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093005792 catalytic residues [active] 741093005793 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 741093005794 Lysis protein S; Region: Lysis_S; pfam04971 741093005795 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093005796 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093005797 tellurite resistance protein terB; Region: terB; cd07176 741093005798 putative metal binding site [ion binding]; other site 741093005799 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093005800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093005801 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 741093005802 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 741093005803 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741093005804 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 741093005805 Hok/gef family; Region: HOK_GEF; pfam01848 741093005806 Protein of unknown function (DUF551); Region: DUF551; pfam04448 741093005807 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 741093005808 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1710 741093005809 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 741093005810 primosomal protein DnaI; Provisional; Region: PRK02854 741093005811 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741093005812 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 741093005813 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741093005814 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093005815 Catalytic site [active] 741093005816 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 741093005817 DicB protein; Region: DicB; pfam05358 741093005818 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741093005819 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 741093005820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741093005821 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093005822 DNA binding site [nucleotide binding] 741093005823 Int/Topo IB signature motif; other site 741093005824 active site 741093005825 DinI-like family; Region: DinI; pfam06183 741093005826 putative transposase OrfB; Reviewed; Region: PHA02517 741093005827 HTH-like domain; Region: HTH_21; pfam13276 741093005828 Integrase core domain; Region: rve; pfam00665 741093005829 Integrase core domain; Region: rve_3; pfam13683 741093005830 Transposase; Region: HTH_Tnp_1; cl17663 741093005831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093005832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 741093005833 MULE transposase domain; Region: MULE; pfam10551 741093005834 Transposase; Region: HTH_Tnp_1; pfam01527 741093005835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093005836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093005837 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093005838 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093005839 homodimer interface [polypeptide binding]; other site 741093005840 putative GKAP docking site [polypeptide binding]; other site 741093005841 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093005842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093005843 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093005844 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093005845 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093005846 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093005847 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093005848 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093005849 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093005850 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093005851 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 741093005852 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093005853 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093005854 MPN+ (JAMM) motif; other site 741093005855 Zinc-binding site [ion binding]; other site 741093005856 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093005857 NlpC/P60 family; Region: NLPC_P60; cl17555 741093005858 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093005859 Phage-related protein [Function unknown]; Region: COG4718 741093005860 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093005861 tape measure domain; Region: tape_meas_nterm; TIGR02675 741093005862 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 741093005863 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093005864 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 741093005865 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 741093005866 Immunoglobulin domain; Region: Ig_3; pfam13927 741093005867 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 741093005868 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 741093005869 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 741093005870 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 741093005871 zinc binding site [ion binding]; other site 741093005872 Phage-related protein [Function unknown]; Region: COG4695 741093005873 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 741093005874 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 741093005875 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 741093005876 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 741093005877 Phage capsid family; Region: Phage_capsid; pfam05065 741093005878 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 741093005879 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 741093005880 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741093005881 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093005882 active site 741093005883 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 741093005884 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093005885 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 741093005886 ORF11CD3 domain; Region: ORF11CD3; pfam10549 741093005887 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093005888 catalytic residues [active] 741093005889 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 741093005890 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093005891 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093005892 tellurite resistance protein terB; Region: terB; cd07176 741093005893 putative metal binding site [ion binding]; other site 741093005894 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 741093005895 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 741093005896 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741093005897 Hok/gef family; Region: HOK_GEF; pfam01848 741093005898 Protein of unknown function (DUF551); Region: DUF551; pfam04448 741093005899 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 741093005900 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 741093005901 putative replication protein; Provisional; Region: PRK12377 741093005902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093005903 Walker A motif; other site 741093005904 ATP binding site [chemical binding]; other site 741093005905 Walker B motif; other site 741093005906 Helix-turn-helix domain; Region: HTH_36; pfam13730 741093005907 primosomal protein DnaI; Provisional; Region: PRK02854 741093005908 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741093005909 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741093005910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093005911 sequence-specific DNA binding site [nucleotide binding]; other site 741093005912 salt bridge; other site 741093005913 transcriptional repressor DicA; Reviewed; Region: PRK09706 741093005914 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 741093005915 DicB protein; Region: DicB; pfam05358 741093005916 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741093005917 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 741093005918 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 741093005919 active site 741093005920 catalytic site [active] 741093005921 substrate binding site [chemical binding]; other site 741093005922 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 741093005923 hypothetical protein; Provisional; Region: PRK02237 741093005924 hypothetical protein; Provisional; Region: PRK13659 741093005925 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 741093005926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093005927 Coenzyme A binding pocket [chemical binding]; other site 741093005928 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 741093005929 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 741093005930 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 741093005931 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741093005932 putative [Fe4-S4] binding site [ion binding]; other site 741093005933 putative molybdopterin cofactor binding site [chemical binding]; other site 741093005934 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741093005935 putative molybdopterin cofactor binding site; other site 741093005936 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 741093005937 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741093005938 putative [Fe4-S4] binding site [ion binding]; other site 741093005939 putative molybdopterin cofactor binding site [chemical binding]; other site 741093005940 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741093005941 putative molybdopterin cofactor binding site; other site 741093005942 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 741093005943 4Fe-4S binding domain; Region: Fer4; cl02805 741093005944 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 741093005945 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 741093005946 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 741093005947 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 741093005948 Cl- selectivity filter; other site 741093005949 Cl- binding residues [ion binding]; other site 741093005950 pore gating glutamate residue; other site 741093005951 dimer interface [polypeptide binding]; other site 741093005952 putative dithiobiotin synthetase; Provisional; Region: PRK12374 741093005953 AAA domain; Region: AAA_26; pfam13500 741093005954 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 741093005955 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741093005956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093005957 nucleotide binding site [chemical binding]; other site 741093005958 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 741093005959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093005960 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 741093005961 dimerization interface [polypeptide binding]; other site 741093005962 substrate binding pocket [chemical binding]; other site 741093005963 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741093005964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093005965 putative substrate translocation pore; other site 741093005966 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 741093005967 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 741093005968 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 741093005969 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 741093005970 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741093005971 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 741093005972 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 741093005973 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 741093005974 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 741093005975 ligand binding site [chemical binding]; other site 741093005976 homodimer interface [polypeptide binding]; other site 741093005977 NAD(P) binding site [chemical binding]; other site 741093005978 trimer interface B [polypeptide binding]; other site 741093005979 trimer interface A [polypeptide binding]; other site 741093005980 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 741093005981 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093005982 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093005983 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093005984 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 741093005985 Spore germination protein; Region: Spore_permease; cl17796 741093005986 dihydromonapterin reductase; Provisional; Region: PRK06483 741093005987 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 741093005988 NADP binding site [chemical binding]; other site 741093005989 substrate binding pocket [chemical binding]; other site 741093005990 active site 741093005991 GlpM protein; Region: GlpM; pfam06942 741093005992 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 741093005993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093005994 active site 741093005995 phosphorylation site [posttranslational modification] 741093005996 intermolecular recognition site; other site 741093005997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093005998 DNA binding site [nucleotide binding] 741093005999 sensor protein RstB; Provisional; Region: PRK10604 741093006000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093006001 dimerization interface [polypeptide binding]; other site 741093006002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093006003 dimer interface [polypeptide binding]; other site 741093006004 phosphorylation site [posttranslational modification] 741093006005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093006006 ATP binding site [chemical binding]; other site 741093006007 Mg2+ binding site [ion binding]; other site 741093006008 G-X-G motif; other site 741093006009 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 741093006010 fumarate hydratase; Reviewed; Region: fumC; PRK00485 741093006011 Class II fumarases; Region: Fumarase_classII; cd01362 741093006012 active site 741093006013 tetramer interface [polypeptide binding]; other site 741093006014 fumarate hydratase; Provisional; Region: PRK15389 741093006015 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 741093006016 Fumarase C-terminus; Region: Fumerase_C; pfam05683 741093006017 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 741093006018 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 741093006019 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 741093006020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 741093006021 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 741093006022 glucuronide transporter; Provisional; Region: PRK09848 741093006023 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741093006024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741093006025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093006026 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 741093006027 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 741093006028 NAD binding site [chemical binding]; other site 741093006029 substrate binding site [chemical binding]; other site 741093006030 homotetramer interface [polypeptide binding]; other site 741093006031 homodimer interface [polypeptide binding]; other site 741093006032 active site 741093006033 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 741093006034 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093006035 DNA binding site [nucleotide binding] 741093006036 domain linker motif; other site 741093006037 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 741093006038 putative dimerization interface [polypeptide binding]; other site 741093006039 putative ligand binding site [chemical binding]; other site 741093006040 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 741093006041 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 741093006042 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093006043 active site turn [active] 741093006044 phosphorylation site [posttranslational modification] 741093006045 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 741093006046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093006047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093006048 homodimer interface [polypeptide binding]; other site 741093006049 catalytic residue [active] 741093006050 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 741093006051 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 741093006052 active site 741093006053 purine riboside binding site [chemical binding]; other site 741093006054 putative oxidoreductase; Provisional; Region: PRK11579 741093006055 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741093006056 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741093006057 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 741093006058 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 741093006059 electron transport complex protein RsxA; Provisional; Region: PRK05151 741093006060 electron transport complex protein RnfB; Provisional; Region: PRK05113 741093006061 Putative Fe-S cluster; Region: FeS; pfam04060 741093006062 4Fe-4S binding domain; Region: Fer4; pfam00037 741093006063 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 741093006064 SLBB domain; Region: SLBB; pfam10531 741093006065 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093006066 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 741093006067 electron transport complex protein RnfG; Validated; Region: PRK01908 741093006068 electron transport complex RsxE subunit; Provisional; Region: PRK12405 741093006069 endonuclease III; Provisional; Region: PRK10702 741093006070 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 741093006071 minor groove reading motif; other site 741093006072 helix-hairpin-helix signature motif; other site 741093006073 substrate binding pocket [chemical binding]; other site 741093006074 active site 741093006075 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 741093006076 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 741093006077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006078 putative substrate translocation pore; other site 741093006079 POT family; Region: PTR2; pfam00854 741093006080 glutathionine S-transferase; Provisional; Region: PRK10542 741093006081 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 741093006082 C-terminal domain interface [polypeptide binding]; other site 741093006083 GSH binding site (G-site) [chemical binding]; other site 741093006084 dimer interface [polypeptide binding]; other site 741093006085 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 741093006086 N-terminal domain interface [polypeptide binding]; other site 741093006087 dimer interface [polypeptide binding]; other site 741093006088 substrate binding pocket (H-site) [chemical binding]; other site 741093006089 pyridoxamine kinase; Validated; Region: PRK05756 741093006090 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 741093006091 dimer interface [polypeptide binding]; other site 741093006092 pyridoxal binding site [chemical binding]; other site 741093006093 ATP binding site [chemical binding]; other site 741093006094 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 741093006095 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 741093006096 active site 741093006097 HIGH motif; other site 741093006098 dimer interface [polypeptide binding]; other site 741093006099 KMSKS motif; other site 741093006100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093006101 RNA binding surface [nucleotide binding]; other site 741093006102 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 741093006103 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 741093006104 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 741093006105 lysozyme inhibitor; Provisional; Region: PRK11372 741093006106 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 741093006107 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 741093006108 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 741093006109 transcriptional regulator SlyA; Provisional; Region: PRK03573 741093006110 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 741093006111 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 741093006112 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 741093006113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093006114 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093006115 Fusaric acid resistance protein family; Region: FUSC; pfam04632 741093006116 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741093006117 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 741093006118 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 741093006119 E-class dimer interface [polypeptide binding]; other site 741093006120 P-class dimer interface [polypeptide binding]; other site 741093006121 active site 741093006122 Cu2+ binding site [ion binding]; other site 741093006123 Zn2+ binding site [ion binding]; other site 741093006124 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093006125 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093006126 active site 741093006127 catalytic tetrad [active] 741093006128 Predicted Fe-S protein [General function prediction only]; Region: COG3313 741093006129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741093006130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093006131 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741093006132 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 741093006133 FMN binding site [chemical binding]; other site 741093006134 active site 741093006135 substrate binding site [chemical binding]; other site 741093006136 catalytic residue [active] 741093006137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741093006138 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 741093006139 dimer interface [polypeptide binding]; other site 741093006140 active site 741093006141 metal binding site [ion binding]; metal-binding site 741093006142 glutathione binding site [chemical binding]; other site 741093006143 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 741093006144 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 741093006145 dimer interface [polypeptide binding]; other site 741093006146 catalytic site [active] 741093006147 putative active site [active] 741093006148 putative substrate binding site [chemical binding]; other site 741093006149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093006150 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 741093006151 ATP binding site [chemical binding]; other site 741093006152 putative Mg++ binding site [ion binding]; other site 741093006153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093006154 nucleotide binding region [chemical binding]; other site 741093006155 ATP-binding site [chemical binding]; other site 741093006156 DEAD/H associated; Region: DEAD_assoc; pfam08494 741093006157 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 741093006158 putative GSH binding site [chemical binding]; other site 741093006159 catalytic residues [active] 741093006160 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093006161 NlpC/P60 family; Region: NLPC_P60; pfam00877 741093006162 superoxide dismutase; Provisional; Region: PRK10543 741093006163 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 741093006164 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 741093006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093006167 putative substrate translocation pore; other site 741093006168 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 741093006169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093006170 DNA binding site [nucleotide binding] 741093006171 domain linker motif; other site 741093006172 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 741093006173 dimerization interface [polypeptide binding]; other site 741093006174 ligand binding site [chemical binding]; other site 741093006175 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 741093006176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093006177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093006178 dimerization interface [polypeptide binding]; other site 741093006179 putative transporter; Provisional; Region: PRK11043 741093006180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006181 putative substrate translocation pore; other site 741093006182 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 741093006183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 741093006184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093006185 S-adenosylmethionine binding site [chemical binding]; other site 741093006186 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 741093006187 Lumazine binding domain; Region: Lum_binding; pfam00677 741093006188 Lumazine binding domain; Region: Lum_binding; pfam00677 741093006189 multidrug efflux protein; Reviewed; Region: PRK01766 741093006190 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 741093006191 cation binding site [ion binding]; other site 741093006192 hypothetical protein; Provisional; Region: PRK09945 741093006193 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 741093006194 putative monooxygenase; Provisional; Region: PRK11118 741093006195 hypothetical protein; Provisional; Region: PRK09897 741093006196 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 741093006197 hypothetical protein; Provisional; Region: PRK09946 741093006198 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 741093006199 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 741093006200 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 741093006201 hypothetical protein; Provisional; Region: PRK09947 741093006202 putative oxidoreductase; Provisional; Region: PRK09849 741093006203 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 741093006204 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 741093006205 hypothetical protein; Provisional; Region: PRK09898 741093006206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093006207 hypothetical protein; Provisional; Region: PRK10292 741093006208 pyruvate kinase; Provisional; Region: PRK09206 741093006209 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 741093006210 domain interfaces; other site 741093006211 active site 741093006212 murein lipoprotein; Provisional; Region: PRK15396 741093006213 L,D-transpeptidase; Provisional; Region: PRK10190 741093006214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093006215 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093006216 cysteine desufuration protein SufE; Provisional; Region: PRK09296 741093006217 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 741093006218 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 741093006219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741093006220 catalytic residue [active] 741093006221 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 741093006222 FeS assembly protein SufD; Region: sufD; TIGR01981 741093006223 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 741093006224 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 741093006225 Walker A/P-loop; other site 741093006226 ATP binding site [chemical binding]; other site 741093006227 Q-loop/lid; other site 741093006228 ABC transporter signature motif; other site 741093006229 Walker B; other site 741093006230 D-loop; other site 741093006231 H-loop/switch region; other site 741093006232 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 741093006233 putative ABC transporter; Region: ycf24; CHL00085 741093006234 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 741093006235 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 741093006236 CoenzymeA binding site [chemical binding]; other site 741093006237 subunit interaction site [polypeptide binding]; other site 741093006238 PHB binding site; other site 741093006239 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 741093006240 FAD binding domain; Region: FAD_binding_4; pfam01565 741093006241 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 741093006242 putative inner membrane protein; Provisional; Region: PRK10983 741093006243 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741093006244 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 741093006245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093006247 putative substrate translocation pore; other site 741093006248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006249 putative substrate translocation pore; other site 741093006250 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 741093006251 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 741093006252 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 741093006253 shikimate binding site; other site 741093006254 NAD(P) binding site [chemical binding]; other site 741093006255 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 741093006256 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 741093006257 active site 741093006258 catalytic residue [active] 741093006259 dimer interface [polypeptide binding]; other site 741093006260 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 741093006261 Coenzyme A transferase; Region: CoA_trans; smart00882 741093006262 Coenzyme A transferase; Region: CoA_trans; cl17247 741093006263 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 741093006264 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 741093006265 active site 741093006266 Cupin domain; Region: Cupin_2; pfam07883 741093006267 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 741093006268 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093006269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093006270 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 741093006271 Ligand binding site [chemical binding]; other site 741093006272 Electron transfer flavoprotein domain; Region: ETF; pfam01012 741093006273 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 741093006274 Electron transfer flavoprotein domain; Region: ETF; smart00893 741093006275 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 741093006276 oxidoreductase; Provisional; Region: PRK10015 741093006277 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 741093006278 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 741093006279 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 741093006280 acyl-activating enzyme (AAE) consensus motif; other site 741093006281 putative AMP binding site [chemical binding]; other site 741093006282 putative active site [active] 741093006283 putative CoA binding site [chemical binding]; other site 741093006284 phosphoenolpyruvate synthase; Validated; Region: PRK06464 741093006285 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 741093006286 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741093006287 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741093006288 PEP synthetase regulatory protein; Provisional; Region: PRK05339 741093006289 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 741093006290 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741093006291 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 741093006292 Uncharacterized conserved protein [Function unknown]; Region: COG0397 741093006293 hypothetical protein; Validated; Region: PRK00029 741093006294 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 741093006295 NlpC/P60 family; Region: NLPC_P60; pfam00877 741093006296 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 741093006297 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741093006298 Walker A/P-loop; other site 741093006299 ATP binding site [chemical binding]; other site 741093006300 Q-loop/lid; other site 741093006301 ABC transporter signature motif; other site 741093006302 Walker B; other site 741093006303 D-loop; other site 741093006304 H-loop/switch region; other site 741093006305 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 741093006306 catalytic residues [active] 741093006307 dimer interface [polypeptide binding]; other site 741093006308 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741093006309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093006310 ABC-ATPase subunit interface; other site 741093006311 dimer interface [polypeptide binding]; other site 741093006312 putative PBP binding regions; other site 741093006313 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741093006314 IHF dimer interface [polypeptide binding]; other site 741093006315 IHF - DNA interface [nucleotide binding]; other site 741093006316 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 741093006317 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 741093006318 putative tRNA-binding site [nucleotide binding]; other site 741093006319 B3/4 domain; Region: B3_4; pfam03483 741093006320 tRNA synthetase B5 domain; Region: B5; smart00874 741093006321 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 741093006322 dimer interface [polypeptide binding]; other site 741093006323 motif 1; other site 741093006324 motif 3; other site 741093006325 motif 2; other site 741093006326 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 741093006327 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 741093006328 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 741093006329 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 741093006330 dimer interface [polypeptide binding]; other site 741093006331 motif 1; other site 741093006332 active site 741093006333 motif 2; other site 741093006334 motif 3; other site 741093006335 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 741093006336 23S rRNA binding site [nucleotide binding]; other site 741093006337 L21 binding site [polypeptide binding]; other site 741093006338 L13 binding site [polypeptide binding]; other site 741093006339 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 741093006340 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 741093006341 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 741093006342 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 741093006343 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 741093006344 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 741093006345 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 741093006346 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 741093006347 active site 741093006348 dimer interface [polypeptide binding]; other site 741093006349 motif 1; other site 741093006350 motif 2; other site 741093006351 motif 3; other site 741093006352 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 741093006353 anticodon binding site; other site 741093006354 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 741093006355 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 741093006356 6-phosphofructokinase 2; Provisional; Region: PRK10294 741093006357 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 741093006358 putative substrate binding site [chemical binding]; other site 741093006359 putative ATP binding site [chemical binding]; other site 741093006360 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 741093006361 Phosphotransferase enzyme family; Region: APH; pfam01636 741093006362 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 741093006363 active site 741093006364 ATP binding site [chemical binding]; other site 741093006365 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 741093006366 YniB-like protein; Region: YniB; pfam14002 741093006367 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 741093006368 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741093006369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093006370 motif II; other site 741093006371 inner membrane protein; Provisional; Region: PRK11648 741093006372 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 741093006373 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741093006374 cell division modulator; Provisional; Region: PRK10113 741093006375 hydroperoxidase II; Provisional; Region: katE; PRK11249 741093006376 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 741093006377 tetramer interface [polypeptide binding]; other site 741093006378 heme binding pocket [chemical binding]; other site 741093006379 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 741093006380 domain interactions; other site 741093006381 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 741093006382 putative active site [active] 741093006383 YdjC motif; other site 741093006384 Mg binding site [ion binding]; other site 741093006385 putative homodimer interface [polypeptide binding]; other site 741093006386 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 741093006387 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 741093006388 NAD binding site [chemical binding]; other site 741093006389 sugar binding site [chemical binding]; other site 741093006390 divalent metal binding site [ion binding]; other site 741093006391 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093006392 dimer interface [polypeptide binding]; other site 741093006393 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 741093006394 Cupin domain; Region: Cupin_2; pfam07883 741093006395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093006396 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 741093006397 methionine cluster; other site 741093006398 active site 741093006399 phosphorylation site [posttranslational modification] 741093006400 metal binding site [ion binding]; metal-binding site 741093006401 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 741093006402 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 741093006403 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 741093006404 active site 741093006405 P-loop; other site 741093006406 phosphorylation site [posttranslational modification] 741093006407 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 741093006408 NAD+ synthetase; Region: nadE; TIGR00552 741093006409 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 741093006410 homodimer interface [polypeptide binding]; other site 741093006411 NAD binding pocket [chemical binding]; other site 741093006412 ATP binding pocket [chemical binding]; other site 741093006413 Mg binding site [ion binding]; other site 741093006414 active-site loop [active] 741093006415 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 741093006416 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 741093006417 GIY-YIG motif/motif A; other site 741093006418 active site 741093006419 catalytic site [active] 741093006420 putative DNA binding site [nucleotide binding]; other site 741093006421 metal binding site [ion binding]; metal-binding site 741093006422 hypothetical protein; Provisional; Region: PRK11396 741093006423 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 741093006424 dimer interface [polypeptide binding]; other site 741093006425 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 741093006426 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 741093006427 putative active site [active] 741093006428 Zn binding site [ion binding]; other site 741093006429 succinylarginine dihydrolase; Provisional; Region: PRK13281 741093006430 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 741093006431 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 741093006432 NAD(P) binding site [chemical binding]; other site 741093006433 catalytic residues [active] 741093006434 arginine succinyltransferase; Provisional; Region: PRK10456 741093006435 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 741093006436 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 741093006437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093006438 inhibitor-cofactor binding pocket; inhibition site 741093006439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093006440 catalytic residue [active] 741093006441 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 741093006442 putative catalytic site [active] 741093006443 putative phosphate binding site [ion binding]; other site 741093006444 active site 741093006445 metal binding site A [ion binding]; metal-binding site 741093006446 DNA binding site [nucleotide binding] 741093006447 putative AP binding site [nucleotide binding]; other site 741093006448 putative metal binding site B [ion binding]; other site 741093006449 Uncharacterized conserved protein [Function unknown]; Region: COG0398 741093006450 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 741093006451 Uncharacterized conserved protein [Function unknown]; Region: COG0398 741093006452 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 741093006453 Uncharacterized conserved protein [Function unknown]; Region: COG2128 741093006454 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 741093006455 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 741093006456 hypothetical protein; Provisional; Region: PRK11622 741093006457 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 741093006458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093006459 dimer interface [polypeptide binding]; other site 741093006460 conserved gate region; other site 741093006461 putative PBP binding loops; other site 741093006462 ABC-ATPase subunit interface; other site 741093006463 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 741093006464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093006465 Walker A/P-loop; other site 741093006466 ATP binding site [chemical binding]; other site 741093006467 Q-loop/lid; other site 741093006468 ABC transporter signature motif; other site 741093006469 Walker B; other site 741093006470 D-loop; other site 741093006471 H-loop/switch region; other site 741093006472 Rhodanese Homology Domain; Region: RHOD; smart00450 741093006473 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 741093006474 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 741093006475 active site residue [active] 741093006476 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 741093006477 active site residue [active] 741093006478 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 741093006479 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 741093006480 active site 741093006481 8-oxo-dGMP binding site [chemical binding]; other site 741093006482 nudix motif; other site 741093006483 metal binding site [ion binding]; metal-binding site 741093006484 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 741093006485 glutamate dehydrogenase; Provisional; Region: PRK09414 741093006486 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 741093006487 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 741093006488 NAD(P) binding site [chemical binding]; other site 741093006489 hypothetical protein; Provisional; Region: PRK11380 741093006490 DNA topoisomerase III; Provisional; Region: PRK07726 741093006491 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 741093006492 active site 741093006493 putative interdomain interaction site [polypeptide binding]; other site 741093006494 putative metal-binding site [ion binding]; other site 741093006495 putative nucleotide binding site [chemical binding]; other site 741093006496 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 741093006497 domain I; other site 741093006498 DNA binding groove [nucleotide binding] 741093006499 phosphate binding site [ion binding]; other site 741093006500 domain II; other site 741093006501 domain III; other site 741093006502 nucleotide binding site [chemical binding]; other site 741093006503 catalytic site [active] 741093006504 domain IV; other site 741093006505 selenophosphate synthetase; Provisional; Region: PRK00943 741093006506 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 741093006507 dimerization interface [polypeptide binding]; other site 741093006508 putative ATP binding site [chemical binding]; other site 741093006509 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 741093006510 putative FMN binding site [chemical binding]; other site 741093006511 protease 4; Provisional; Region: PRK10949 741093006512 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 741093006513 tandem repeat interface [polypeptide binding]; other site 741093006514 oligomer interface [polypeptide binding]; other site 741093006515 active site residues [active] 741093006516 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 741093006517 tandem repeat interface [polypeptide binding]; other site 741093006518 oligomer interface [polypeptide binding]; other site 741093006519 active site residues [active] 741093006520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 741093006521 Uncharacterized conserved protein [Function unknown]; Region: COG2968 741093006522 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 741093006523 active site 741093006524 homodimer interface [polypeptide binding]; other site 741093006525 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 741093006526 Isochorismatase family; Region: Isochorismatase; pfam00857 741093006527 catalytic triad [active] 741093006528 metal binding site [ion binding]; metal-binding site 741093006529 conserved cis-peptide bond; other site 741093006530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006532 Transposase; Region: HTH_Tnp_1; cl17663 741093006533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093006534 putative transposase OrfB; Reviewed; Region: PHA02517 741093006535 HTH-like domain; Region: HTH_21; pfam13276 741093006536 Integrase core domain; Region: rve; pfam00665 741093006537 Integrase core domain; Region: rve_3; pfam13683 741093006538 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741093006539 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741093006540 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093006541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093006542 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093006543 active site 741093006544 catalytic tetrad [active] 741093006545 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093006546 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 741093006547 substrate binding site [chemical binding]; other site 741093006548 ATP binding site [chemical binding]; other site 741093006549 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 741093006550 intersubunit interface [polypeptide binding]; other site 741093006551 active site 741093006552 zinc binding site [ion binding]; other site 741093006553 Na+ binding site [ion binding]; other site 741093006554 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093006555 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 741093006556 inhibitor binding site; inhibition site 741093006557 catalytic Zn binding site [ion binding]; other site 741093006558 structural Zn binding site [ion binding]; other site 741093006559 NADP binding site [chemical binding]; other site 741093006560 tetramer interface [polypeptide binding]; other site 741093006561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006563 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093006564 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 741093006565 putative NAD(P) binding site [chemical binding]; other site 741093006566 catalytic Zn binding site [ion binding]; other site 741093006567 structural Zn binding site [ion binding]; other site 741093006568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 741093006569 methionine sulfoxide reductase B; Provisional; Region: PRK00222 741093006570 SelR domain; Region: SelR; pfam01641 741093006571 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 741093006572 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 741093006573 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 741093006574 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 741093006575 active site 741093006576 phosphate binding residues; other site 741093006577 catalytic residues [active] 741093006578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093006579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093006580 active site 741093006581 catalytic tetrad [active] 741093006582 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 741093006583 PrkA family serine protein kinase; Provisional; Region: PRK15455 741093006584 AAA ATPase domain; Region: AAA_16; pfam13191 741093006585 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 741093006586 hypothetical protein; Provisional; Region: PRK05325 741093006587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093006588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093006589 metal binding site [ion binding]; metal-binding site 741093006590 active site 741093006591 I-site; other site 741093006592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093006593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093006594 metal binding site [ion binding]; metal-binding site 741093006595 active site 741093006596 I-site; other site 741093006597 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 741093006598 putative deacylase active site [active] 741093006599 Predicted membrane protein [Function unknown]; Region: COG2707 741093006600 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093006601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093006602 cyanate transporter; Region: CynX; TIGR00896 741093006603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006604 Uncharacterized conserved protein [Function unknown]; Region: COG3189 741093006605 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 741093006606 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 741093006607 Domain of unknown function (DUF333); Region: DUF333; pfam03891 741093006608 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 741093006609 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741093006610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093006611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093006612 metal binding site [ion binding]; metal-binding site 741093006613 active site 741093006614 I-site; other site 741093006615 hypothetical protein; Provisional; Region: PRK10457 741093006616 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 741093006617 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 741093006618 leucine export protein LeuE; Provisional; Region: PRK10958 741093006619 transcriptional activator TtdR; Provisional; Region: PRK09801 741093006620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093006621 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 741093006622 putative effector binding pocket; other site 741093006623 putative dimerization interface [polypeptide binding]; other site 741093006624 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 741093006625 tartrate dehydrogenase; Region: TTC; TIGR02089 741093006626 putative transporter; Provisional; Region: PRK09950 741093006627 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 741093006628 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 741093006629 [2Fe-2S] cluster binding site [ion binding]; other site 741093006630 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 741093006631 putative alpha subunit interface [polypeptide binding]; other site 741093006632 putative active site [active] 741093006633 putative substrate binding site [chemical binding]; other site 741093006634 Fe binding site [ion binding]; other site 741093006635 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 741093006636 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 741093006637 FMN-binding pocket [chemical binding]; other site 741093006638 flavin binding motif; other site 741093006639 phosphate binding motif [ion binding]; other site 741093006640 beta-alpha-beta structure motif; other site 741093006641 NAD binding pocket [chemical binding]; other site 741093006642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093006643 catalytic loop [active] 741093006644 iron binding site [ion binding]; other site 741093006645 ribonuclease D; Provisional; Region: PRK10829 741093006646 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 741093006647 catalytic site [active] 741093006648 putative active site [active] 741093006649 putative substrate binding site [chemical binding]; other site 741093006650 Helicase and RNase D C-terminal; Region: HRDC; smart00341 741093006651 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 741093006652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741093006653 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 741093006654 acyl-activating enzyme (AAE) consensus motif; other site 741093006655 putative AMP binding site [chemical binding]; other site 741093006656 putative active site [active] 741093006657 putative CoA binding site [chemical binding]; other site 741093006658 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 741093006659 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 741093006660 Glycoprotease family; Region: Peptidase_M22; pfam00814 741093006661 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 741093006662 DEAD/DEAH box helicase; Region: DEAD; pfam00270 741093006663 DEAD_2; Region: DEAD_2; pfam06733 741093006664 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 741093006665 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 741093006666 homotrimer interaction site [polypeptide binding]; other site 741093006667 putative active site [active] 741093006668 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 741093006669 hypothetical protein; Provisional; Region: PRK05114 741093006670 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 741093006671 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 741093006672 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 741093006673 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 741093006674 putative active site [active] 741093006675 putative CoA binding site [chemical binding]; other site 741093006676 nudix motif; other site 741093006677 metal binding site [ion binding]; metal-binding site 741093006678 L-serine deaminase; Provisional; Region: PRK15023 741093006679 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 741093006680 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 741093006681 phage resistance protein; Provisional; Region: PRK10551 741093006682 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741093006683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093006684 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 741093006685 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 741093006686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741093006687 Transporter associated domain; Region: CorC_HlyC; smart01091 741093006688 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 741093006689 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 741093006690 active pocket/dimerization site; other site 741093006691 active site 741093006692 phosphorylation site [posttranslational modification] 741093006693 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 741093006694 active site 741093006695 phosphorylation site [posttranslational modification] 741093006696 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 741093006697 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 741093006698 Predicted membrane protein [Function unknown]; Region: COG4811 741093006699 hypothetical protein; Provisional; Region: PRK11469 741093006700 Domain of unknown function DUF; Region: DUF204; pfam02659 741093006701 Domain of unknown function DUF; Region: DUF204; pfam02659 741093006702 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 741093006703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093006704 S-adenosylmethionine binding site [chemical binding]; other site 741093006705 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741093006706 DNA-binding site [nucleotide binding]; DNA binding site 741093006707 RNA-binding motif; other site 741093006708 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 741093006709 YebO-like protein; Region: YebO; pfam13974 741093006710 PhoPQ regulatory protein; Provisional; Region: PRK10299 741093006711 YobH-like protein; Region: YobH; pfam13996 741093006712 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 741093006713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093006714 dimerization interface [polypeptide binding]; other site 741093006715 putative Zn2+ binding site [ion binding]; other site 741093006716 putative DNA binding site [nucleotide binding]; other site 741093006717 Bacterial transcriptional regulator; Region: IclR; pfam01614 741093006718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093006719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093006720 putative substrate translocation pore; other site 741093006721 Predicted integral membrane protein [Function unknown]; Region: COG5521 741093006722 heat shock protein HtpX; Provisional; Region: PRK05457 741093006723 carboxy-terminal protease; Provisional; Region: PRK11186 741093006724 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 741093006725 protein binding site [polypeptide binding]; other site 741093006726 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 741093006727 Catalytic dyad [active] 741093006728 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 741093006729 ProP expression regulator; Provisional; Region: PRK04950 741093006730 ProQ/FINO family; Region: ProQ; pfam04352 741093006731 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 741093006732 GAF domain; Region: GAF_2; pfam13185 741093006733 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 741093006734 Paraquat-inducible protein A; Region: PqiA; pfam04403 741093006735 Paraquat-inducible protein A; Region: PqiA; pfam04403 741093006736 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 741093006737 mce related protein; Region: MCE; pfam02470 741093006738 mce related protein; Region: MCE; pfam02470 741093006739 mce related protein; Region: MCE; pfam02470 741093006740 mce related protein; Region: MCE; pfam02470 741093006741 mce related protein; Region: MCE; pfam02470 741093006742 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 741093006743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093006744 S-adenosylmethionine binding site [chemical binding]; other site 741093006745 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 741093006746 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 741093006747 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741093006748 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 741093006749 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741093006750 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 741093006751 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 741093006752 hypothetical protein; Provisional; Region: PRK10301 741093006753 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 741093006754 Predicted amidohydrolase [General function prediction only]; Region: COG0388 741093006755 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 741093006756 exodeoxyribonuclease X; Provisional; Region: PRK07983 741093006757 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 741093006758 active site 741093006759 catalytic site [active] 741093006760 substrate binding site [chemical binding]; other site 741093006761 protease 2; Provisional; Region: PRK10115 741093006762 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741093006763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 741093006764 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 741093006765 putative metal binding site [ion binding]; other site 741093006766 hypothetical protein; Provisional; Region: PRK13680 741093006767 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 741093006768 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 741093006769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741093006770 ATP-grasp domain; Region: ATP-grasp; pfam02222 741093006771 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 741093006772 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 741093006773 active site 741093006774 intersubunit interface [polypeptide binding]; other site 741093006775 catalytic residue [active] 741093006776 phosphogluconate dehydratase; Validated; Region: PRK09054 741093006777 6-phosphogluconate dehydratase; Region: edd; TIGR01196 741093006778 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 741093006779 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 741093006780 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 741093006781 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 741093006782 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741093006783 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741093006784 putative active site [active] 741093006785 pyruvate kinase; Provisional; Region: PRK05826 741093006786 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 741093006787 domain interfaces; other site 741093006788 active site 741093006789 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741093006790 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741093006791 putative acyl-acceptor binding pocket; other site 741093006792 putative peptidase; Provisional; Region: PRK11649 741093006793 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 741093006794 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093006795 Peptidase family M23; Region: Peptidase_M23; pfam01551 741093006796 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 741093006797 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 741093006798 metal binding site [ion binding]; metal-binding site 741093006799 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 741093006800 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 741093006801 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 741093006802 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093006803 ABC-ATPase subunit interface; other site 741093006804 dimer interface [polypeptide binding]; other site 741093006805 putative PBP binding regions; other site 741093006806 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 741093006807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093006808 Walker A motif; other site 741093006809 ATP binding site [chemical binding]; other site 741093006810 Walker B motif; other site 741093006811 arginine finger; other site 741093006812 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 741093006813 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 741093006814 RuvA N terminal domain; Region: RuvA_N; pfam01330 741093006815 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 741093006816 hypothetical protein; Provisional; Region: PRK11470 741093006817 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 741093006818 active site 741093006819 putative DNA-binding cleft [nucleotide binding]; other site 741093006820 dimer interface [polypeptide binding]; other site 741093006821 hypothetical protein; Validated; Region: PRK00110 741093006822 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 741093006823 nudix motif; other site 741093006824 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 741093006825 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 741093006826 dimer interface [polypeptide binding]; other site 741093006827 anticodon binding site; other site 741093006828 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 741093006829 homodimer interface [polypeptide binding]; other site 741093006830 motif 1; other site 741093006831 active site 741093006832 motif 2; other site 741093006833 GAD domain; Region: GAD; pfam02938 741093006834 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 741093006835 motif 3; other site 741093006836 Isochorismatase family; Region: Isochorismatase; pfam00857 741093006837 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 741093006838 catalytic triad [active] 741093006839 conserved cis-peptide bond; other site 741093006840 hypothetical protein; Provisional; Region: PRK10302 741093006841 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 741093006842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093006843 S-adenosylmethionine binding site [chemical binding]; other site 741093006844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093006845 S-adenosylmethionine binding site [chemical binding]; other site 741093006846 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 741093006847 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 741093006848 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 741093006849 molybdopterin cofactor binding site [chemical binding]; other site 741093006850 substrate binding site [chemical binding]; other site 741093006851 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 741093006852 molybdopterin cofactor binding site; other site 741093006853 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 741093006854 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 741093006855 copper homeostasis protein CutC; Provisional; Region: PRK11572 741093006856 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 741093006857 putative metal binding site [ion binding]; other site 741093006858 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 741093006859 arginyl-tRNA synthetase; Region: argS; TIGR00456 741093006860 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 741093006861 active site 741093006862 HIGH motif; other site 741093006863 KMSK motif region; other site 741093006864 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 741093006865 tRNA binding surface [nucleotide binding]; other site 741093006866 anticodon binding site; other site 741093006867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 741093006868 Flagellar protein FlhE; Region: FlhE; pfam06366 741093006869 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 741093006870 FHIPEP family; Region: FHIPEP; pfam00771 741093006871 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 741093006872 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 741093006873 chemotaxis regulator CheZ; Provisional; Region: PRK11166 741093006874 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 741093006875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093006876 active site 741093006877 phosphorylation site [posttranslational modification] 741093006878 intermolecular recognition site; other site 741093006879 dimerization interface [polypeptide binding]; other site 741093006880 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 741093006881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093006882 active site 741093006883 phosphorylation site [posttranslational modification] 741093006884 intermolecular recognition site; other site 741093006885 dimerization interface [polypeptide binding]; other site 741093006886 CheB methylesterase; Region: CheB_methylest; pfam01339 741093006887 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 741093006888 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 741093006889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093006890 S-adenosylmethionine binding site [chemical binding]; other site 741093006891 methyl-accepting protein IV; Provisional; Region: PRK09793 741093006892 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741093006893 dimer interface [polypeptide binding]; other site 741093006894 ligand binding site [chemical binding]; other site 741093006895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093006896 dimerization interface [polypeptide binding]; other site 741093006897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741093006898 dimer interface [polypeptide binding]; other site 741093006899 putative CheW interface [polypeptide binding]; other site 741093006900 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 741093006901 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741093006902 dimer interface [polypeptide binding]; other site 741093006903 ligand binding site [chemical binding]; other site 741093006904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093006905 dimerization interface [polypeptide binding]; other site 741093006906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741093006907 dimer interface [polypeptide binding]; other site 741093006908 putative CheW interface [polypeptide binding]; other site 741093006909 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 741093006910 putative CheA interaction surface; other site 741093006911 chemotaxis protein CheA; Provisional; Region: PRK10547 741093006912 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741093006913 putative binding surface; other site 741093006914 active site 741093006915 CheY binding; Region: CheY-binding; pfam09078 741093006916 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 741093006917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093006918 ATP binding site [chemical binding]; other site 741093006919 Mg2+ binding site [ion binding]; other site 741093006920 G-X-G motif; other site 741093006921 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 741093006922 flagellar motor protein MotB; Validated; Region: motB; PRK09041 741093006923 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 741093006924 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093006925 ligand binding site [chemical binding]; other site 741093006926 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 741093006927 flagellar motor protein MotA; Validated; Region: PRK09110 741093006928 transcriptional activator FlhC; Provisional; Region: PRK12722 741093006929 transcriptional activator FlhD; Provisional; Region: PRK02909 741093006930 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093006931 Ligand Binding Site [chemical binding]; other site 741093006932 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 741093006933 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 741093006934 active site 741093006935 homotetramer interface [polypeptide binding]; other site 741093006936 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 741093006937 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 741093006938 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 741093006939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093006940 Walker A/P-loop; other site 741093006941 ATP binding site [chemical binding]; other site 741093006942 Q-loop/lid; other site 741093006943 ABC transporter signature motif; other site 741093006944 Walker B; other site 741093006945 D-loop; other site 741093006946 H-loop/switch region; other site 741093006947 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093006948 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 741093006949 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 741093006950 ligand binding site [chemical binding]; other site 741093006951 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 741093006952 Ferritin-like domain; Region: Ferritin; pfam00210 741093006953 ferroxidase diiron center [ion binding]; other site 741093006954 YecR-like lipoprotein; Region: YecR; pfam13992 741093006955 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 741093006956 Ferritin-like domain; Region: Ferritin; pfam00210 741093006957 ferroxidase diiron center [ion binding]; other site 741093006958 probable metal-binding protein; Region: matur_matur; TIGR03853 741093006959 tyrosine transporter TyrP; Provisional; Region: PRK15132 741093006960 aromatic amino acid transport protein; Region: araaP; TIGR00837 741093006961 hypothetical protein; Provisional; Region: PRK10396 741093006962 yecA family protein; Region: ygfB_yecA; TIGR02292 741093006963 SEC-C motif; Region: SEC-C; pfam02810 741093006964 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 741093006965 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 741093006966 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 741093006967 GIY-YIG motif/motif A; other site 741093006968 active site 741093006969 catalytic site [active] 741093006970 putative DNA binding site [nucleotide binding]; other site 741093006971 metal binding site [ion binding]; metal-binding site 741093006972 UvrB/uvrC motif; Region: UVR; pfam02151 741093006973 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 741093006974 Helix-hairpin-helix motif; Region: HHH; pfam00633 741093006975 response regulator; Provisional; Region: PRK09483 741093006976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093006977 active site 741093006978 phosphorylation site [posttranslational modification] 741093006979 intermolecular recognition site; other site 741093006980 dimerization interface [polypeptide binding]; other site 741093006981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093006982 DNA binding residues [nucleotide binding] 741093006983 dimerization interface [polypeptide binding]; other site 741093006984 hypothetical protein; Provisional; Region: PRK10613 741093006985 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 741093006986 Autoinducer binding domain; Region: Autoind_bind; pfam03472 741093006987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093006988 DNA binding residues [nucleotide binding] 741093006989 dimerization interface [polypeptide binding]; other site 741093006990 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 741093006991 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741093006992 Walker A/P-loop; other site 741093006993 ATP binding site [chemical binding]; other site 741093006994 Q-loop/lid; other site 741093006995 ABC transporter signature motif; other site 741093006996 Walker B; other site 741093006997 D-loop; other site 741093006998 H-loop/switch region; other site 741093006999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093007000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093007001 dimer interface [polypeptide binding]; other site 741093007002 conserved gate region; other site 741093007003 putative PBP binding loops; other site 741093007004 ABC-ATPase subunit interface; other site 741093007005 D-cysteine desulfhydrase; Validated; Region: PRK03910 741093007006 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 741093007007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093007008 catalytic residue [active] 741093007009 cystine transporter subunit; Provisional; Region: PRK11260 741093007010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093007011 substrate binding pocket [chemical binding]; other site 741093007012 membrane-bound complex binding site; other site 741093007013 hinge residues; other site 741093007014 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 741093007015 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 741093007016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741093007017 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 741093007018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741093007019 DNA binding residues [nucleotide binding] 741093007020 flagellin; Validated; Region: PRK08026 741093007021 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 741093007022 Flagellin protein; Region: FliC; pfam12445 741093007023 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 741093007024 flagellar capping protein; Reviewed; Region: fliD; PRK08032 741093007025 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 741093007026 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 741093007027 Flagellar protein FliS; Region: FliS; cl00654 741093007028 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 741093007029 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 741093007030 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 741093007031 active site 741093007032 Na/Ca binding site [ion binding]; other site 741093007033 catalytic site [active] 741093007034 lipoprotein; Provisional; Region: PRK10397 741093007035 putative inner membrane protein; Provisional; Region: PRK11099 741093007036 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 741093007037 CPxP motif; other site 741093007038 hypothetical protein; Provisional; Region: PRK09951 741093007039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741093007040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093007041 Coenzyme A binding pocket [chemical binding]; other site 741093007042 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 741093007043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093007044 Coenzyme A binding pocket [chemical binding]; other site 741093007045 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 741093007046 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741093007047 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 741093007048 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 741093007049 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 741093007050 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 741093007051 flagellar motor switch protein FliG; Region: fliG; TIGR00207 741093007052 FliG C-terminal domain; Region: FliG_C; pfam01706 741093007053 flagellar assembly protein H; Validated; Region: fliH; PRK05687 741093007054 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 741093007055 Flagellar assembly protein FliH; Region: FliH; pfam02108 741093007056 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 741093007057 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 741093007058 Walker A motif/ATP binding site; other site 741093007059 Walker B motif; other site 741093007060 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 741093007061 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 741093007062 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 741093007063 flagellar hook-length control protein; Provisional; Region: PRK10118 741093007064 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 741093007065 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 741093007066 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 741093007067 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 741093007068 flagellar motor switch protein; Validated; Region: fliN; PRK05698 741093007069 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 741093007070 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 741093007071 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 741093007072 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 741093007073 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 741093007074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093007075 DNA binding residues [nucleotide binding] 741093007076 dimerization interface [polypeptide binding]; other site 741093007077 hypothetical protein; Provisional; Region: PRK10708 741093007078 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 741093007079 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 741093007080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093007081 active site 741093007082 motif I; other site 741093007083 motif II; other site 741093007084 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 741093007085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093007086 metal binding site [ion binding]; metal-binding site 741093007087 active site 741093007088 I-site; other site 741093007089 Uncharacterized small protein [Function unknown]; Region: COG5475 741093007090 hypothetical protein; Provisional; Region: PRK10062 741093007091 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 741093007092 EamA-like transporter family; Region: EamA; pfam00892 741093007093 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 741093007094 additional DNA contacts [nucleotide binding]; other site 741093007095 mismatch recognition site; other site 741093007096 active site 741093007097 zinc binding site [ion binding]; other site 741093007098 DNA intercalation site [nucleotide binding]; other site 741093007099 DNA cytosine methylase; Provisional; Region: PRK10458 741093007100 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 741093007101 cofactor binding site; other site 741093007102 DNA binding site [nucleotide binding] 741093007103 substrate interaction site [chemical binding]; other site 741093007104 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 741093007105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741093007106 Zn2+ binding site [ion binding]; other site 741093007107 Mg2+ binding site [ion binding]; other site 741093007108 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093007109 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741093007110 trimer interface [polypeptide binding]; other site 741093007111 eyelet of channel; other site 741093007112 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 741093007113 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093007114 chaperone protein HchA; Provisional; Region: PRK04155 741093007115 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 741093007116 dimer interface [polypeptide binding]; other site 741093007117 metal binding site [ion binding]; metal-binding site 741093007118 potential oxyanion hole; other site 741093007119 potential catalytic triad [active] 741093007120 conserved cys residue [active] 741093007121 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 741093007122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093007123 dimer interface [polypeptide binding]; other site 741093007124 phosphorylation site [posttranslational modification] 741093007125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093007126 ATP binding site [chemical binding]; other site 741093007127 Mg2+ binding site [ion binding]; other site 741093007128 G-X-G motif; other site 741093007129 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 741093007130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093007131 active site 741093007132 phosphorylation site [posttranslational modification] 741093007133 intermolecular recognition site; other site 741093007134 dimerization interface [polypeptide binding]; other site 741093007135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093007136 DNA binding site [nucleotide binding] 741093007137 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 741093007138 active site 741093007139 homotetramer interface [polypeptide binding]; other site 741093007140 TMAO/DMSO reductase; Reviewed; Region: PRK05363 741093007141 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 741093007142 Moco binding site; other site 741093007143 metal coordination site [ion binding]; other site 741093007144 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 741093007145 zinc/cadmium-binding protein; Provisional; Region: PRK10306 741093007146 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 741093007147 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 741093007148 EspF protein repeat; Region: EspF; pfam04806 741093007149 EspF protein repeat; Region: EspF; pfam04806 741093007150 EspF protein repeat; Region: EspF; pfam04806 741093007151 EspF protein repeat; Region: EspF; pfam04806 741093007152 EspF protein repeat; Region: EspF; pfam04806 741093007153 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093007154 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093007155 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093007156 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 741093007157 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093007158 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 741093007159 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093007160 NlpC/P60 family; Region: NLPC_P60; cl17555 741093007161 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093007162 Phage-related protein [Function unknown]; Region: COG4718 741093007163 Minor tail protein T; Region: Phage_tail_T; cl05636 741093007164 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 741093007165 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741093007166 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 741093007167 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 741093007168 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 741093007169 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 741093007170 tandem repeat interface [polypeptide binding]; other site 741093007171 oligomer interface [polypeptide binding]; other site 741093007172 active site residues [active] 741093007173 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741093007174 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093007175 gpW; Region: gpW; pfam02831 741093007176 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741093007177 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 741093007178 PerC transcriptional activator; Region: PerC; pfam06069 741093007179 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741093007180 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093007181 catalytic residues [active] 741093007182 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 741093007183 Lysis protein S; Region: Lysis_S; pfam04971 741093007184 Transposase; Region: HTH_Tnp_1; cl17663 741093007185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093007186 putative transposase OrfB; Reviewed; Region: PHA02517 741093007187 HTH-like domain; Region: HTH_21; pfam13276 741093007188 Integrase core domain; Region: rve; pfam00665 741093007189 Integrase core domain; Region: rve_3; pfam13683 741093007190 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093007191 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093007192 tellurite resistance protein terB; Region: terB; cd07176 741093007193 putative metal binding site [ion binding]; other site 741093007194 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 741093007195 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 741093007196 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741093007197 Hok/gef family; Region: HOK_GEF; pfam01848 741093007198 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 741093007199 Pyocin large subunit [General function prediction only]; Region: COG5529 741093007200 primosomal protein DnaI; Provisional; Region: PRK02854 741093007201 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741093007202 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 741093007203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093007204 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741093007205 non-specific DNA binding site [nucleotide binding]; other site 741093007206 salt bridge; other site 741093007207 sequence-specific DNA binding site [nucleotide binding]; other site 741093007208 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093007209 Catalytic site [active] 741093007210 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 741093007211 DicB protein; Region: DicB; pfam05358 741093007212 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741093007213 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 741093007214 active site 741093007215 substrate binding site [chemical binding]; other site 741093007216 catalytic site [active] 741093007217 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 741093007218 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741093007219 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741093007220 active site 741093007221 DNA binding site [nucleotide binding] 741093007222 Int/Topo IB signature motif; other site 741093007223 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 741093007224 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 741093007225 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007226 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007227 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007228 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007229 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007230 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007231 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007232 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007233 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 741093007234 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 741093007235 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 741093007236 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007237 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 741093007238 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007239 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007240 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093007241 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741093007242 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 741093007243 shikimate transporter; Provisional; Region: PRK09952 741093007244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093007245 putative substrate translocation pore; other site 741093007246 AMP nucleosidase; Provisional; Region: PRK08292 741093007247 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 741093007248 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 741093007249 hypothetical protein; Provisional; Region: PRK12378 741093007250 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 741093007251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093007252 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 741093007253 putative substrate binding site [chemical binding]; other site 741093007254 dimerization interface [polypeptide binding]; other site 741093007255 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 741093007256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093007257 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 741093007258 putative dimerization interface [polypeptide binding]; other site 741093007259 L,D-transpeptidase; Provisional; Region: PRK10190 741093007260 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741093007261 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 741093007262 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 741093007263 putative dimer interface [polypeptide binding]; other site 741093007264 active site pocket [active] 741093007265 putative cataytic base [active] 741093007266 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 741093007267 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 741093007268 homotrimer interface [polypeptide binding]; other site 741093007269 Walker A motif; other site 741093007270 GTP binding site [chemical binding]; other site 741093007271 Walker B motif; other site 741093007272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093007273 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093007274 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093007275 homodimer interface [polypeptide binding]; other site 741093007276 putative GKAP docking site [polypeptide binding]; other site 741093007277 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093007278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093007279 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093007280 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093007281 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093007282 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 741093007283 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093007284 N-terminal plug; other site 741093007285 ligand-binding site [chemical binding]; other site 741093007286 Transposase; Region: HTH_Tnp_1; cl17663 741093007287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093007288 putative transposase OrfB; Reviewed; Region: PHA02517 741093007289 HTH-like domain; Region: HTH_21; pfam13276 741093007290 Integrase core domain; Region: rve; pfam00665 741093007291 Integrase core domain; Region: rve_3; pfam13683 741093007292 hypothetical protein; Provisional; Region: PRK09866 741093007293 YjcZ-like protein; Region: YjcZ; pfam13990 741093007294 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 741093007295 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 741093007296 nucleophile elbow; other site 741093007297 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 741093007298 Domain of unknown function (DUF932); Region: DUF932; pfam06067 741093007299 Antirestriction protein; Region: Antirestrict; pfam03230 741093007300 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 741093007301 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 741093007302 MPN+ (JAMM) motif; other site 741093007303 Zinc-binding site [ion binding]; other site 741093007304 Protein of unknown function (DUF987); Region: DUF987; pfam06174 741093007305 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 741093007306 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 741093007307 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 741093007308 Switch II region; other site 741093007309 G4 box; other site 741093007310 G5 box; other site 741093007311 hypothetical protein; Provisional; Region: PRK05423 741093007312 Predicted membrane protein [Function unknown]; Region: COG1289 741093007313 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741093007314 DNA gyrase inhibitor; Provisional; Region: PRK10016 741093007315 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 741093007316 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 741093007317 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 741093007318 exonuclease I; Provisional; Region: sbcB; PRK11779 741093007319 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 741093007320 active site 741093007321 catalytic site [active] 741093007322 substrate binding site [chemical binding]; other site 741093007323 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 741093007324 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 741093007325 CPxP motif; other site 741093007326 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 741093007327 Sulphur transport; Region: Sulf_transp; pfam04143 741093007328 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 741093007329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093007330 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 741093007331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093007332 dimerization interface [polypeptide binding]; other site 741093007333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741093007334 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 741093007335 putative NAD(P) binding site [chemical binding]; other site 741093007336 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 741093007337 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 741093007338 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 741093007339 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 741093007340 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 741093007341 NAD binding site [chemical binding]; other site 741093007342 dimerization interface [polypeptide binding]; other site 741093007343 product binding site; other site 741093007344 substrate binding site [chemical binding]; other site 741093007345 zinc binding site [ion binding]; other site 741093007346 catalytic residues [active] 741093007347 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 741093007348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093007349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093007350 homodimer interface [polypeptide binding]; other site 741093007351 catalytic residue [active] 741093007352 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 741093007353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093007354 active site 741093007355 motif I; other site 741093007356 motif II; other site 741093007357 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 741093007358 putative active site pocket [active] 741093007359 4-fold oligomerization interface [polypeptide binding]; other site 741093007360 metal binding residues [ion binding]; metal-binding site 741093007361 3-fold/trimer interface [polypeptide binding]; other site 741093007362 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 741093007363 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 741093007364 putative active site [active] 741093007365 oxyanion strand; other site 741093007366 catalytic triad [active] 741093007367 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 741093007368 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 741093007369 catalytic residues [active] 741093007370 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 741093007371 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 741093007372 substrate binding site [chemical binding]; other site 741093007373 glutamase interaction surface [polypeptide binding]; other site 741093007374 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 741093007375 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 741093007376 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 741093007377 metal binding site [ion binding]; metal-binding site 741093007378 chain length determinant protein WzzB; Provisional; Region: PRK15471 741093007379 Chain length determinant protein; Region: Wzz; pfam02706 741093007380 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 741093007381 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 741093007382 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 741093007383 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 741093007384 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741093007385 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 741093007386 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 741093007387 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 741093007388 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 741093007389 putative trimer interface [polypeptide binding]; other site 741093007390 putative CoA binding site [chemical binding]; other site 741093007391 phosphomannomutase CpsG; Provisional; Region: PRK15414 741093007392 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 741093007393 active site 741093007394 substrate binding site [chemical binding]; other site 741093007395 metal binding site [ion binding]; metal-binding site 741093007396 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 741093007397 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 741093007398 Substrate binding site; other site 741093007399 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 741093007400 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 741093007401 active site 741093007402 GDP-Mannose binding site [chemical binding]; other site 741093007403 dimer interface [polypeptide binding]; other site 741093007404 modified nudix motif 741093007405 metal binding site [ion binding]; metal-binding site 741093007406 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 741093007407 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 741093007408 NADP binding site [chemical binding]; other site 741093007409 active site 741093007410 putative substrate binding site [chemical binding]; other site 741093007411 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 741093007412 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 741093007413 NADP-binding site; other site 741093007414 homotetramer interface [polypeptide binding]; other site 741093007415 substrate binding site [chemical binding]; other site 741093007416 homodimer interface [polypeptide binding]; other site 741093007417 active site 741093007418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741093007419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 741093007420 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 741093007421 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 741093007422 inhibitor-cofactor binding pocket; inhibition site 741093007423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093007424 catalytic residue [active] 741093007425 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 741093007426 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 741093007427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 741093007428 active site 741093007429 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 741093007430 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 741093007431 active site 741093007432 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 741093007433 active site 741093007434 tetramer interface; other site 741093007435 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 741093007436 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741093007437 putative NAD(P) binding site [chemical binding]; other site 741093007438 active site 741093007439 putative substrate binding site [chemical binding]; other site 741093007440 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 741093007441 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 741093007442 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 741093007443 putative ADP-binding pocket [chemical binding]; other site 741093007444 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 741093007445 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 741093007446 colanic acid exporter; Provisional; Region: PRK10459 741093007447 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 741093007448 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 741093007449 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 741093007450 phosphomannomutase CpsG; Provisional; Region: PRK15414 741093007451 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 741093007452 active site 741093007453 substrate binding site [chemical binding]; other site 741093007454 metal binding site [ion binding]; metal-binding site 741093007455 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 741093007456 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 741093007457 Substrate binding site; other site 741093007458 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 741093007459 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 741093007460 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 741093007461 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 741093007462 active site 741093007463 GDP-Mannose binding site [chemical binding]; other site 741093007464 dimer interface [polypeptide binding]; other site 741093007465 modified nudix motif 741093007466 metal binding site [ion binding]; metal-binding site 741093007467 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 741093007468 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 741093007469 NADP binding site [chemical binding]; other site 741093007470 active site 741093007471 putative substrate binding site [chemical binding]; other site 741093007472 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 741093007473 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 741093007474 NADP-binding site; other site 741093007475 homotetramer interface [polypeptide binding]; other site 741093007476 substrate binding site [chemical binding]; other site 741093007477 homodimer interface [polypeptide binding]; other site 741093007478 active site 741093007479 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 741093007480 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 741093007481 putative trimer interface [polypeptide binding]; other site 741093007482 putative active site [active] 741093007483 putative substrate binding site [chemical binding]; other site 741093007484 putative CoA binding site [chemical binding]; other site 741093007485 putative glycosyl transferase; Provisional; Region: PRK10063 741093007486 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 741093007487 metal-binding site 741093007488 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 741093007489 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 741093007490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 741093007491 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 741093007492 putative acyl transferase; Provisional; Region: PRK10191 741093007493 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 741093007494 trimer interface [polypeptide binding]; other site 741093007495 active site 741093007496 substrate binding site [chemical binding]; other site 741093007497 CoA binding site [chemical binding]; other site 741093007498 putative glycosyl transferase; Provisional; Region: PRK10018 741093007499 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 741093007500 active site 741093007501 tyrosine kinase; Provisional; Region: PRK11519 741093007502 Chain length determinant protein; Region: Wzz; pfam02706 741093007503 Chain length determinant protein; Region: Wzz; cl15801 741093007504 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 741093007505 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741093007506 Low molecular weight phosphatase family; Region: LMWPc; cd00115 741093007507 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 741093007508 active site 741093007509 polysaccharide export protein Wza; Provisional; Region: PRK15078 741093007510 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 741093007511 SLBB domain; Region: SLBB; pfam10531 741093007512 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 741093007513 FOG: CBS domain [General function prediction only]; Region: COG0517 741093007514 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741093007515 Transporter associated domain; Region: CorC_HlyC; smart01091 741093007516 Phage-related protein [Function unknown]; Region: COG4679 741093007517 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 741093007518 putative assembly protein; Provisional; Region: PRK10833 741093007519 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 741093007520 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 741093007521 trimer interface [polypeptide binding]; other site 741093007522 active site 741093007523 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 741093007524 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 741093007525 ATP-binding site [chemical binding]; other site 741093007526 Sugar specificity; other site 741093007527 Pyrimidine base specificity; other site 741093007528 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 741093007529 AlkA N-terminal domain; Region: AlkA_N; smart01009 741093007530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 741093007531 minor groove reading motif; other site 741093007532 helix-hairpin-helix signature motif; other site 741093007533 substrate binding pocket [chemical binding]; other site 741093007534 active site 741093007535 putative chaperone; Provisional; Region: PRK11678 741093007536 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 741093007537 nucleotide binding site [chemical binding]; other site 741093007538 putative NEF/HSP70 interaction site [polypeptide binding]; other site 741093007539 SBD interface [polypeptide binding]; other site 741093007540 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 741093007541 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 741093007542 substrate binding site [chemical binding]; other site 741093007543 activation loop (A-loop); other site 741093007544 Protein phosphatase 2C; Region: PP2C_2; pfam13672 741093007545 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 741093007546 metal ion-dependent adhesion site (MIDAS); other site 741093007547 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 741093007548 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093007549 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093007550 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 741093007551 Protein export membrane protein; Region: SecD_SecF; cl14618 741093007552 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 741093007553 putative transporter; Provisional; Region: PRK10504 741093007554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093007555 putative substrate translocation pore; other site 741093007556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093007557 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 741093007558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093007559 dimerization interface [polypeptide binding]; other site 741093007560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093007561 dimer interface [polypeptide binding]; other site 741093007562 phosphorylation site [posttranslational modification] 741093007563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093007564 ATP binding site [chemical binding]; other site 741093007565 Mg2+ binding site [ion binding]; other site 741093007566 G-X-G motif; other site 741093007567 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 741093007568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093007569 active site 741093007570 phosphorylation site [posttranslational modification] 741093007571 intermolecular recognition site; other site 741093007572 dimerization interface [polypeptide binding]; other site 741093007573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093007574 DNA binding site [nucleotide binding] 741093007575 Uncharacterized conserved protein [Function unknown]; Region: COG3422 741093007576 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 741093007577 putative protease; Provisional; Region: PRK15452 741093007578 Peptidase family U32; Region: Peptidase_U32; pfam01136 741093007579 lipid kinase; Reviewed; Region: PRK13054 741093007580 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 741093007581 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741093007582 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741093007583 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093007584 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 741093007585 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 741093007586 putative NAD(P) binding site [chemical binding]; other site 741093007587 catalytic Zn binding site [ion binding]; other site 741093007588 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 741093007589 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 741093007590 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 741093007591 active site 741093007592 P-loop; other site 741093007593 phosphorylation site [posttranslational modification] 741093007594 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093007595 active site 741093007596 phosphorylation site [posttranslational modification] 741093007597 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 741093007598 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 741093007599 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 741093007600 intersubunit interface [polypeptide binding]; other site 741093007601 active site 741093007602 zinc binding site [ion binding]; other site 741093007603 Na+ binding site [ion binding]; other site 741093007604 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 741093007605 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 741093007606 putative active site; other site 741093007607 catalytic residue [active] 741093007608 nucleoside transporter; Region: 2A0110; TIGR00889 741093007609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093007610 putative substrate translocation pore; other site 741093007611 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 741093007612 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093007613 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 741093007614 substrate binding site [chemical binding]; other site 741093007615 ATP binding site [chemical binding]; other site 741093007616 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741093007617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093007618 DNA-binding site [nucleotide binding]; DNA binding site 741093007619 UTRA domain; Region: UTRA; pfam07702 741093007620 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 741093007621 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 741093007622 active site 741093007623 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 741093007624 dimer interface [polypeptide binding]; other site 741093007625 substrate binding site [chemical binding]; other site 741093007626 ATP binding site [chemical binding]; other site 741093007627 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 741093007628 substrate binding site [chemical binding]; other site 741093007629 multimerization interface [polypeptide binding]; other site 741093007630 ATP binding site [chemical binding]; other site 741093007631 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 741093007632 putative metal binding site [ion binding]; other site 741093007633 putative homodimer interface [polypeptide binding]; other site 741093007634 putative homotetramer interface [polypeptide binding]; other site 741093007635 putative homodimer-homodimer interface [polypeptide binding]; other site 741093007636 putative allosteric switch controlling residues; other site 741093007637 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 741093007638 Predicted integral membrane protein [Function unknown]; Region: COG5455 741093007639 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 741093007640 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 741093007641 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 741093007642 PapC N-terminal domain; Region: PapC_N; pfam13954 741093007643 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093007644 PapC C-terminal domain; Region: PapC_C; pfam13953 741093007645 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 741093007646 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093007647 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093007648 Fimbrial protein; Region: Fimbrial; cl01416 741093007649 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 741093007650 antiporter inner membrane protein; Provisional; Region: PRK11670 741093007651 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 741093007652 Walker A motif; other site 741093007653 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 741093007654 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 741093007655 active site 741093007656 HIGH motif; other site 741093007657 KMSKS motif; other site 741093007658 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 741093007659 tRNA binding surface [nucleotide binding]; other site 741093007660 anticodon binding site; other site 741093007661 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 741093007662 dimer interface [polypeptide binding]; other site 741093007663 putative tRNA-binding site [nucleotide binding]; other site 741093007664 potential frameshift: common BLAST hit: gi|291283364|ref|YP_003500182.1| interrupted molybdate metabolism regulator 741093007665 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 741093007666 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 741093007667 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 741093007668 MoxR-like ATPases [General function prediction only]; Region: COG0714 741093007669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093007670 Walker A motif; other site 741093007671 ATP binding site [chemical binding]; other site 741093007672 Walker B motif; other site 741093007673 arginine finger; other site 741093007674 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 741093007675 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 741093007676 metal ion-dependent adhesion site (MIDAS); other site 741093007677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 741093007678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 741093007679 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 741093007680 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 741093007681 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 741093007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093007683 active site 741093007684 phosphorylation site [posttranslational modification] 741093007685 intermolecular recognition site; other site 741093007686 dimerization interface [polypeptide binding]; other site 741093007687 LytTr DNA-binding domain; Region: LytTR; pfam04397 741093007688 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 741093007689 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 741093007690 GAF domain; Region: GAF; pfam01590 741093007691 Histidine kinase; Region: His_kinase; pfam06580 741093007692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093007693 ATP binding site [chemical binding]; other site 741093007694 Mg2+ binding site [ion binding]; other site 741093007695 G-X-G motif; other site 741093007696 DinI-like family; Region: DinI; pfam06183 741093007697 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093007698 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 741093007699 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 741093007700 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093007701 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 741093007702 Phage-related protein, tail component [Function unknown]; Region: COG4723 741093007703 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741093007704 MPN+ (JAMM) motif; other site 741093007705 Zinc-binding site [ion binding]; other site 741093007706 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741093007707 NlpC/P60 family; Region: NLPC_P60; cl17555 741093007708 Phage-related protein [Function unknown]; Region: gp18; COG4672 741093007709 Phage-related protein [Function unknown]; Region: COG4718 741093007710 Phage-related minor tail protein [Function unknown]; Region: COG5281 741093007711 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093007712 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741093007713 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 741093007714 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741093007715 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 741093007716 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 741093007717 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741093007718 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 741093007719 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 741093007720 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 741093007721 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 741093007722 Uncharacterized conserved protein [Function unknown]; Region: COG5471 741093007723 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 741093007724 Transposase; Region: HTH_Tnp_1; cl17663 741093007725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093007726 putative transposase OrfB; Reviewed; Region: PHA02517 741093007727 HTH-like domain; Region: HTH_21; pfam13276 741093007728 Integrase core domain; Region: rve; pfam00665 741093007729 Integrase core domain; Region: rve_3; pfam13683 741093007730 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 741093007731 Clp protease; Region: CLP_protease; pfam00574 741093007732 oligomer interface [polypeptide binding]; other site 741093007733 active site residues [active] 741093007734 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741093007735 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741093007736 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741093007737 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 741093007738 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 741093007739 ORF11CD3 domain; Region: ORF11CD3; pfam10549 741093007740 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741093007741 catalytic residues [active] 741093007742 Lysis protein S; Region: Lysis_S; pfam04971 741093007743 Protein of unknown function (DUF826); Region: DUF826; pfam05696 741093007744 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 741093007745 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093007746 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093007747 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 741093007748 Ribosome inactivating protein; Region: RIP; pfam00161 741093007749 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 741093007750 Phage NinH protein; Region: Phage_NinH; pfam06322 741093007751 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 741093007752 NinF protein; Region: NinF; pfam05810 741093007753 NINE Protein; Region: NinE; pfam05322 741093007754 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 741093007755 NinB protein; Region: NinB; pfam05772 741093007756 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 741093007757 Replication protein P; Region: Phage_lambda_P; pfam06992 741093007758 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 741093007759 Bacteriophage CII protein; Region: Phage_CII; pfam05269 741093007760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093007761 non-specific DNA binding site [nucleotide binding]; other site 741093007762 salt bridge; other site 741093007763 sequence-specific DNA binding site [nucleotide binding]; other site 741093007764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093007765 non-specific DNA binding site [nucleotide binding]; other site 741093007766 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741093007767 salt bridge; other site 741093007768 sequence-specific DNA binding site [nucleotide binding]; other site 741093007769 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093007770 Catalytic site [active] 741093007771 Superinfection exclusion protein B; Region: SieB; pfam14163 741093007772 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 741093007773 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 741093007774 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 741093007775 phage recombination protein Bet; Region: bet_lambda; TIGR01913 741093007776 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 741093007777 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 741093007778 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 741093007779 DksA-like zinc finger domain containing protein; Region: PHA00080 741093007780 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 741093007781 Protein of unknown function (DUF551); Region: DUF551; pfam04448 741093007782 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 741093007783 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 741093007784 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 741093007785 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093007786 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 741093007787 Int/Topo IB signature motif; other site 741093007788 transcriptional regulator MirA; Provisional; Region: PRK15043 741093007789 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 741093007790 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741093007791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093007792 dimer interface [polypeptide binding]; other site 741093007793 conserved gate region; other site 741093007794 putative PBP binding loops; other site 741093007795 ABC-ATPase subunit interface; other site 741093007796 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 741093007797 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 741093007798 Walker A/P-loop; other site 741093007799 ATP binding site [chemical binding]; other site 741093007800 Q-loop/lid; other site 741093007801 ABC transporter signature motif; other site 741093007802 Walker B; other site 741093007803 D-loop; other site 741093007804 H-loop/switch region; other site 741093007805 CBS domain; Region: CBS; pfam00571 741093007806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093007807 dimer interface [polypeptide binding]; other site 741093007808 conserved gate region; other site 741093007809 ABC-ATPase subunit interface; other site 741093007810 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 741093007811 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 741093007812 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 741093007813 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 741093007814 D-lactate dehydrogenase; Provisional; Region: PRK11183 741093007815 FAD binding domain; Region: FAD_binding_4; pfam01565 741093007816 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 741093007817 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 741093007818 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 741093007819 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 741093007820 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741093007821 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 741093007822 oxidoreductase; Provisional; Region: PRK12743 741093007823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741093007824 NAD(P) binding site [chemical binding]; other site 741093007825 active site 741093007826 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 741093007827 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 741093007828 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 741093007829 FMN binding site [chemical binding]; other site 741093007830 active site 741093007831 catalytic residues [active] 741093007832 substrate binding site [chemical binding]; other site 741093007833 salicylate hydroxylase; Provisional; Region: PRK08163 741093007834 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741093007835 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 741093007836 maleylacetoacetate isomerase; Region: maiA; TIGR01262 741093007837 C-terminal domain interface [polypeptide binding]; other site 741093007838 GSH binding site (G-site) [chemical binding]; other site 741093007839 putative dimer interface [polypeptide binding]; other site 741093007840 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 741093007841 dimer interface [polypeptide binding]; other site 741093007842 N-terminal domain interface [polypeptide binding]; other site 741093007843 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 741093007844 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 741093007845 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 741093007846 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 741093007847 Cupin domain; Region: Cupin_2; pfam07883 741093007848 Cupin domain; Region: Cupin_2; cl17218 741093007849 benzoate transport; Region: 2A0115; TIGR00895 741093007850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093007851 putative substrate translocation pore; other site 741093007852 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 741093007853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093007854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093007855 dimerization interface [polypeptide binding]; other site 741093007856 hypothetical protein; Provisional; Region: PRK01821 741093007857 hypothetical protein; Provisional; Region: PRK10711 741093007858 cytidine deaminase; Provisional; Region: PRK09027 741093007859 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 741093007860 active site 741093007861 catalytic motif [active] 741093007862 Zn binding site [ion binding]; other site 741093007863 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 741093007864 active site 741093007865 catalytic motif [active] 741093007866 Zn binding site [ion binding]; other site 741093007867 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 741093007868 putative active site [active] 741093007869 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 741093007870 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 741093007871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741093007872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093007873 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 741093007874 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 741093007875 homodimer interface [polypeptide binding]; other site 741093007876 active site 741093007877 FMN binding site [chemical binding]; other site 741093007878 substrate binding site [chemical binding]; other site 741093007879 4Fe-4S binding domain; Region: Fer4; pfam00037 741093007880 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093007881 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093007882 TM-ABC transporter signature motif; other site 741093007883 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093007884 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 741093007885 Walker A/P-loop; other site 741093007886 ATP binding site [chemical binding]; other site 741093007887 Q-loop/lid; other site 741093007888 ABC transporter signature motif; other site 741093007889 Walker B; other site 741093007890 D-loop; other site 741093007891 H-loop/switch region; other site 741093007892 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093007893 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 741093007894 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 741093007895 ligand binding site [chemical binding]; other site 741093007896 calcium binding site [ion binding]; other site 741093007897 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 741093007898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093007899 DNA binding site [nucleotide binding] 741093007900 domain linker motif; other site 741093007901 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 741093007902 dimerization interface (closed form) [polypeptide binding]; other site 741093007903 ligand binding site [chemical binding]; other site 741093007904 Predicted membrane protein [Function unknown]; Region: COG2311 741093007905 hypothetical protein; Provisional; Region: PRK10835 741093007906 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 741093007907 homodecamer interface [polypeptide binding]; other site 741093007908 GTP cyclohydrolase I; Provisional; Region: PLN03044 741093007909 active site 741093007910 putative catalytic site residues [active] 741093007911 zinc binding site [ion binding]; other site 741093007912 GTP-CH-I/GFRP interaction surface; other site 741093007913 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 741093007914 S-formylglutathione hydrolase; Region: PLN02442 741093007915 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 741093007916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093007917 N-terminal plug; other site 741093007918 ligand-binding site [chemical binding]; other site 741093007919 lysine transporter; Provisional; Region: PRK10836 741093007920 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 741093007921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093007922 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 741093007923 putative dimerization interface [polypeptide binding]; other site 741093007924 conserved hypothetical integral membrane protein; Region: TIGR00698 741093007925 endonuclease IV; Provisional; Region: PRK01060 741093007926 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 741093007927 AP (apurinic/apyrimidinic) site pocket; other site 741093007928 DNA interaction; other site 741093007929 Metal-binding active site; metal-binding site 741093007930 putative kinase; Provisional; Region: PRK09954 741093007931 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 741093007932 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 741093007933 substrate binding site [chemical binding]; other site 741093007934 ATP binding site [chemical binding]; other site 741093007935 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 741093007936 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 741093007937 Nucleoside recognition; Region: Gate; pfam07670 741093007938 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 741093007939 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 741093007940 active site 741093007941 tetramer interface [polypeptide binding]; other site 741093007942 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 741093007943 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 741093007944 ligand binding site [chemical binding]; other site 741093007945 flexible hinge region; other site 741093007946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 741093007947 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 741093007948 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 741093007949 Nucleoside recognition; Region: Gate; pfam07670 741093007950 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 741093007951 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 741093007952 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 741093007953 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093007954 substrate binding site [chemical binding]; other site 741093007955 ATP binding site [chemical binding]; other site 741093007956 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 741093007957 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 741093007958 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741093007959 active site 741093007960 P-loop; other site 741093007961 phosphorylation site [posttranslational modification] 741093007962 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 741093007963 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 741093007964 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 741093007965 putative substrate binding site [chemical binding]; other site 741093007966 putative ATP binding site [chemical binding]; other site 741093007967 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 741093007968 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093007969 active site 741093007970 phosphorylation site [posttranslational modification] 741093007971 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093007972 dimerization domain swap beta strand [polypeptide binding]; other site 741093007973 regulatory protein interface [polypeptide binding]; other site 741093007974 active site 741093007975 regulatory phosphorylation site [posttranslational modification]; other site 741093007976 sugar efflux transporter B; Provisional; Region: PRK15011 741093007977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093007978 putative substrate translocation pore; other site 741093007979 elongation factor P; Provisional; Region: PRK04542 741093007980 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 741093007981 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 741093007982 RNA binding site [nucleotide binding]; other site 741093007983 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 741093007984 RNA binding site [nucleotide binding]; other site 741093007985 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 741093007986 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741093007987 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741093007988 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 741093007989 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 741093007990 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 741093007991 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741093007992 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 741093007993 active site 741093007994 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 741093007995 NlpC/P60 family; Region: NLPC_P60; pfam00877 741093007996 phage resistance protein; Provisional; Region: PRK10551 741093007997 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741093007998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093007999 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 741093008000 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 741093008001 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 741093008002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093008003 dimer interface [polypeptide binding]; other site 741093008004 conserved gate region; other site 741093008005 putative PBP binding loops; other site 741093008006 ABC-ATPase subunit interface; other site 741093008007 microcin C ABC transporter permease; Provisional; Region: PRK15021 741093008008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093008009 dimer interface [polypeptide binding]; other site 741093008010 conserved gate region; other site 741093008011 ABC-ATPase subunit interface; other site 741093008012 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 741093008013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093008014 Walker A/P-loop; other site 741093008015 ATP binding site [chemical binding]; other site 741093008016 Q-loop/lid; other site 741093008017 ABC transporter signature motif; other site 741093008018 Walker B; other site 741093008019 D-loop; other site 741093008020 H-loop/switch region; other site 741093008021 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741093008022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093008023 Walker A/P-loop; other site 741093008024 ATP binding site [chemical binding]; other site 741093008025 Q-loop/lid; other site 741093008026 ABC transporter signature motif; other site 741093008027 Walker B; other site 741093008028 D-loop; other site 741093008029 H-loop/switch region; other site 741093008030 hypothetical protein; Provisional; Region: PRK11835 741093008031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008032 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 741093008033 putative substrate translocation pore; other site 741093008034 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 741093008035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093008036 RNA binding surface [nucleotide binding]; other site 741093008037 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 741093008038 active site 741093008039 uracil binding [chemical binding]; other site 741093008040 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 741093008041 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093008042 ATP binding site [chemical binding]; other site 741093008043 putative Mg++ binding site [ion binding]; other site 741093008044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093008045 nucleotide binding region [chemical binding]; other site 741093008046 ATP-binding site [chemical binding]; other site 741093008047 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 741093008048 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 741093008049 5S rRNA interface [nucleotide binding]; other site 741093008050 CTC domain interface [polypeptide binding]; other site 741093008051 L16 interface [polypeptide binding]; other site 741093008052 Nucleoid-associated protein [General function prediction only]; Region: COG3081 741093008053 nucleoid-associated protein NdpA; Validated; Region: PRK00378 741093008054 hypothetical protein; Provisional; Region: PRK13689 741093008055 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 741093008056 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 741093008057 Sulfatase; Region: Sulfatase; pfam00884 741093008058 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 741093008059 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 741093008060 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093008061 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093008062 transcriptional regulator NarP; Provisional; Region: PRK10403 741093008063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093008064 active site 741093008065 phosphorylation site [posttranslational modification] 741093008066 intermolecular recognition site; other site 741093008067 dimerization interface [polypeptide binding]; other site 741093008068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093008069 DNA binding residues [nucleotide binding] 741093008070 dimerization interface [polypeptide binding]; other site 741093008071 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 741093008072 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 741093008073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 741093008074 binding surface 741093008075 TPR motif; other site 741093008076 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 741093008077 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 741093008078 catalytic residues [active] 741093008079 central insert; other site 741093008080 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 741093008081 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 741093008082 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 741093008083 heme exporter protein CcmC; Region: ccmC; TIGR01191 741093008084 heme exporter protein CcmB; Region: ccmB; TIGR01190 741093008085 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 741093008086 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 741093008087 Walker A/P-loop; other site 741093008088 ATP binding site [chemical binding]; other site 741093008089 Q-loop/lid; other site 741093008090 ABC transporter signature motif; other site 741093008091 Walker B; other site 741093008092 D-loop; other site 741093008093 H-loop/switch region; other site 741093008094 cytochrome c-type protein NapC; Provisional; Region: PRK10617 741093008095 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 741093008096 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 741093008097 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 741093008098 4Fe-4S binding domain; Region: Fer4_5; pfam12801 741093008099 4Fe-4S binding domain; Region: Fer4; cl02805 741093008100 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 741093008101 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 741093008102 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 741093008103 [4Fe-4S] binding site [ion binding]; other site 741093008104 molybdopterin cofactor binding site; other site 741093008105 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 741093008106 molybdopterin cofactor binding site; other site 741093008107 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 741093008108 ferredoxin-type protein; Provisional; Region: PRK10194 741093008109 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 741093008110 secondary substrate binding site; other site 741093008111 primary substrate binding site; other site 741093008112 inhibition loop; other site 741093008113 dimerization interface [polypeptide binding]; other site 741093008114 malate:quinone oxidoreductase; Validated; Region: PRK05257 741093008115 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 741093008116 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 741093008117 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 741093008118 Walker A/P-loop; other site 741093008119 ATP binding site [chemical binding]; other site 741093008120 Q-loop/lid; other site 741093008121 ABC transporter signature motif; other site 741093008122 Walker B; other site 741093008123 D-loop; other site 741093008124 H-loop/switch region; other site 741093008125 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 741093008126 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 741093008127 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 741093008128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093008129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093008130 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 741093008131 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741093008132 DNA binding site [nucleotide binding] 741093008133 active site 741093008134 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 741093008135 ApbE family; Region: ApbE; pfam02424 741093008136 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741093008137 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741093008138 trimer interface [polypeptide binding]; other site 741093008139 eyelet of channel; other site 741093008140 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 741093008141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093008142 ATP binding site [chemical binding]; other site 741093008143 G-X-G motif; other site 741093008144 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741093008145 putative binding surface; other site 741093008146 active site 741093008147 transcriptional regulator RcsB; Provisional; Region: PRK10840 741093008148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093008149 active site 741093008150 phosphorylation site [posttranslational modification] 741093008151 intermolecular recognition site; other site 741093008152 dimerization interface [polypeptide binding]; other site 741093008153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093008154 DNA binding residues [nucleotide binding] 741093008155 dimerization interface [polypeptide binding]; other site 741093008156 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 741093008157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093008158 dimer interface [polypeptide binding]; other site 741093008159 phosphorylation site [posttranslational modification] 741093008160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093008161 ATP binding site [chemical binding]; other site 741093008162 Mg2+ binding site [ion binding]; other site 741093008163 G-X-G motif; other site 741093008164 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 741093008165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093008166 active site 741093008167 phosphorylation site [posttranslational modification] 741093008168 intermolecular recognition site; other site 741093008169 dimerization interface [polypeptide binding]; other site 741093008170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 741093008171 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 741093008172 Predicted secreted protein [Function unknown]; Region: COG5445 741093008173 Stage II sporulation protein; Region: SpoIID; pfam08486 741093008174 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 741093008175 Predicted secreted protein [Function unknown]; Region: COG5445 741093008176 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 741093008177 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 741093008178 MG2 domain; Region: A2M_N; pfam01835 741093008179 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 741093008180 Alpha-2-macroglobulin family; Region: A2M; pfam00207 741093008181 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 741093008182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 741093008183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 741093008184 DNA gyrase subunit A; Validated; Region: PRK05560 741093008185 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 741093008186 CAP-like domain; other site 741093008187 active site 741093008188 primary dimer interface [polypeptide binding]; other site 741093008189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093008190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093008191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093008192 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093008193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093008194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093008195 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 741093008196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093008197 S-adenosylmethionine binding site [chemical binding]; other site 741093008198 adhesin; Provisional; Region: PRK09752 741093008199 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741093008200 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093008201 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 741093008202 ATP cone domain; Region: ATP-cone; pfam03477 741093008203 Class I ribonucleotide reductase; Region: RNR_I; cd01679 741093008204 active site 741093008205 dimer interface [polypeptide binding]; other site 741093008206 catalytic residues [active] 741093008207 effector binding site; other site 741093008208 R2 peptide binding site; other site 741093008209 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 741093008210 dimer interface [polypeptide binding]; other site 741093008211 putative radical transfer pathway; other site 741093008212 diiron center [ion binding]; other site 741093008213 tyrosyl radical; other site 741093008214 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 741093008215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093008216 catalytic loop [active] 741093008217 iron binding site [ion binding]; other site 741093008218 hypothetical protein; Provisional; Region: PRK09902 741093008219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093008220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008221 putative substrate translocation pore; other site 741093008222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093008223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093008224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741093008225 dimerization interface [polypeptide binding]; other site 741093008226 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 741093008227 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 741093008228 active site 741093008229 catalytic site [active] 741093008230 metal binding site [ion binding]; metal-binding site 741093008231 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 741093008232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008233 putative substrate translocation pore; other site 741093008234 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 741093008235 hydroxyglutarate oxidase; Provisional; Region: PRK11728 741093008236 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 741093008237 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 741093008238 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 741093008239 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 741093008240 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093008241 Cysteine-rich domain; Region: CCG; pfam02754 741093008242 Cysteine-rich domain; Region: CCG; pfam02754 741093008243 hypothetical protein; Provisional; Region: PRK09956 741093008244 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 741093008245 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 741093008246 D-galactonate transporter; Region: 2A0114; TIGR00893 741093008247 putative transposase OrfB; Reviewed; Region: PHA02517 741093008248 HTH-like domain; Region: HTH_21; pfam13276 741093008249 Integrase core domain; Region: rve; pfam00665 741093008250 Integrase core domain; Region: rve_3; pfam13683 741093008251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008252 putative substrate translocation pore; other site 741093008253 L-rhamnonate dehydratase; Provisional; Region: PRK15440 741093008254 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 741093008255 putative active site pocket [active] 741093008256 putative metal binding site [ion binding]; other site 741093008257 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 741093008258 Transcriptional regulator [Transcription]; Region: IclR; COG1414 741093008259 Bacterial transcriptional regulator; Region: IclR; pfam01614 741093008260 hypothetical protein; Provisional; Region: PRK03673 741093008261 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 741093008262 putative MPT binding site; other site 741093008263 Competence-damaged protein; Region: CinA; cl00666 741093008264 YfaZ precursor; Region: YfaZ; pfam07437 741093008265 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 741093008266 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 741093008267 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 741093008268 catalytic core [active] 741093008269 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 741093008270 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 741093008271 inhibitor-cofactor binding pocket; inhibition site 741093008272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093008273 catalytic residue [active] 741093008274 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 741093008275 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 741093008276 Ligand binding site; other site 741093008277 Putative Catalytic site; other site 741093008278 DXD motif; other site 741093008279 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 741093008280 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 741093008281 substrate binding site [chemical binding]; other site 741093008282 cosubstrate binding site; other site 741093008283 catalytic site [active] 741093008284 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 741093008285 active site 741093008286 hexamer interface [polypeptide binding]; other site 741093008287 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 741093008288 NAD binding site [chemical binding]; other site 741093008289 substrate binding site [chemical binding]; other site 741093008290 active site 741093008291 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 741093008292 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 741093008293 putative active site [active] 741093008294 putative catalytic site [active] 741093008295 putative Zn binding site [ion binding]; other site 741093008296 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 741093008297 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 741093008298 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 741093008299 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 741093008300 signal transduction protein PmrD; Provisional; Region: PRK15450 741093008301 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 741093008302 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 741093008303 acyl-activating enzyme (AAE) consensus motif; other site 741093008304 putative AMP binding site [chemical binding]; other site 741093008305 putative active site [active] 741093008306 putative CoA binding site [chemical binding]; other site 741093008307 O-succinylbenzoate synthase; Provisional; Region: PRK05105 741093008308 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 741093008309 active site 741093008310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741093008311 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 741093008312 substrate binding site [chemical binding]; other site 741093008313 oxyanion hole (OAH) forming residues; other site 741093008314 trimer interface [polypeptide binding]; other site 741093008315 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 741093008316 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 741093008317 nucleophilic elbow; other site 741093008318 catalytic triad; other site 741093008319 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 741093008320 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 741093008321 dimer interface [polypeptide binding]; other site 741093008322 tetramer interface [polypeptide binding]; other site 741093008323 PYR/PP interface [polypeptide binding]; other site 741093008324 TPP binding site [chemical binding]; other site 741093008325 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 741093008326 TPP-binding site; other site 741093008327 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 741093008328 isochorismate synthases; Region: isochor_syn; TIGR00543 741093008329 hypothetical protein; Provisional; Region: PRK10404 741093008330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093008331 Coenzyme A binding pocket [chemical binding]; other site 741093008332 ribonuclease BN; Region: true_RNase_BN; TIGR02649 741093008333 deubiquitinase; Provisional; Region: PRK11836 741093008334 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 741093008335 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 741093008336 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 741093008337 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093008338 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 741093008339 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093008340 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 741093008341 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 741093008342 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093008343 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 741093008344 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 741093008345 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 741093008346 4Fe-4S binding domain; Region: Fer4; pfam00037 741093008347 4Fe-4S binding domain; Region: Fer4; pfam00037 741093008348 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 741093008349 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 741093008350 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093008351 catalytic loop [active] 741093008352 iron binding site [ion binding]; other site 741093008353 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 741093008354 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 741093008355 [4Fe-4S] binding site [ion binding]; other site 741093008356 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 741093008357 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 741093008358 SLBB domain; Region: SLBB; pfam10531 741093008359 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 741093008360 NADH dehydrogenase subunit E; Validated; Region: PRK07539 741093008361 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 741093008362 putative dimer interface [polypeptide binding]; other site 741093008363 [2Fe-2S] cluster binding site [ion binding]; other site 741093008364 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 741093008365 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 741093008366 NADH dehydrogenase subunit D; Validated; Region: PRK06075 741093008367 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 741093008368 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 741093008369 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 741093008370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093008371 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 741093008372 putative dimerization interface [polypeptide binding]; other site 741093008373 aminotransferase AlaT; Validated; Region: PRK09265 741093008374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093008375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093008376 homodimer interface [polypeptide binding]; other site 741093008377 catalytic residue [active] 741093008378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741093008379 Zn2+ binding site [ion binding]; other site 741093008380 Mg2+ binding site [ion binding]; other site 741093008381 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 741093008382 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741093008383 TrkA-C domain; Region: TrkA_C; pfam02080 741093008384 TrkA-C domain; Region: TrkA_C; pfam02080 741093008385 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 741093008386 putative phosphatase; Provisional; Region: PRK11587 741093008387 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741093008388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093008389 motif II; other site 741093008390 hypothetical protein; Validated; Region: PRK05445 741093008391 hypothetical protein; Provisional; Region: PRK01816 741093008392 propionate/acetate kinase; Provisional; Region: PRK12379 741093008393 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 741093008394 phosphate acetyltransferase; Reviewed; Region: PRK05632 741093008395 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741093008396 DRTGG domain; Region: DRTGG; pfam07085 741093008397 phosphate acetyltransferase; Region: pta; TIGR00651 741093008398 hypothetical protein; Provisional; Region: PRK11588 741093008399 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 741093008400 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 741093008401 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 741093008402 nudix motif; other site 741093008403 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 741093008404 active site 741093008405 metal binding site [ion binding]; metal-binding site 741093008406 homotetramer interface [polypeptide binding]; other site 741093008407 glutathione S-transferase; Provisional; Region: PRK15113 741093008408 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 741093008409 C-terminal domain interface [polypeptide binding]; other site 741093008410 GSH binding site (G-site) [chemical binding]; other site 741093008411 dimer interface [polypeptide binding]; other site 741093008412 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 741093008413 N-terminal domain interface [polypeptide binding]; other site 741093008414 putative dimer interface [polypeptide binding]; other site 741093008415 putative substrate binding pocket (H-site) [chemical binding]; other site 741093008416 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 741093008417 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 741093008418 C-terminal domain interface [polypeptide binding]; other site 741093008419 GSH binding site (G-site) [chemical binding]; other site 741093008420 dimer interface [polypeptide binding]; other site 741093008421 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 741093008422 N-terminal domain interface [polypeptide binding]; other site 741093008423 putative dimer interface [polypeptide binding]; other site 741093008424 active site 741093008425 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 741093008426 homooctamer interface [polypeptide binding]; other site 741093008427 active site 741093008428 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 741093008429 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 741093008430 putative NAD(P) binding site [chemical binding]; other site 741093008431 putative active site [active] 741093008432 putative transposase; Provisional; Region: PRK09857 741093008433 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 741093008434 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 741093008435 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741093008436 Walker A/P-loop; other site 741093008437 ATP binding site [chemical binding]; other site 741093008438 Q-loop/lid; other site 741093008439 ABC transporter signature motif; other site 741093008440 Walker B; other site 741093008441 D-loop; other site 741093008442 H-loop/switch region; other site 741093008443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093008444 dimer interface [polypeptide binding]; other site 741093008445 conserved gate region; other site 741093008446 putative PBP binding loops; other site 741093008447 ABC-ATPase subunit interface; other site 741093008448 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093008449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093008450 dimer interface [polypeptide binding]; other site 741093008451 conserved gate region; other site 741093008452 putative PBP binding loops; other site 741093008453 ABC-ATPase subunit interface; other site 741093008454 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 741093008455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093008456 substrate binding pocket [chemical binding]; other site 741093008457 membrane-bound complex binding site; other site 741093008458 hinge residues; other site 741093008459 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 741093008460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093008461 substrate binding pocket [chemical binding]; other site 741093008462 membrane-bound complex binding site; other site 741093008463 hinge residues; other site 741093008464 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 741093008465 Flavoprotein; Region: Flavoprotein; pfam02441 741093008466 amidophosphoribosyltransferase; Provisional; Region: PRK09246 741093008467 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 741093008468 active site 741093008469 tetramer interface [polypeptide binding]; other site 741093008470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093008471 active site 741093008472 colicin V production protein; Provisional; Region: PRK10845 741093008473 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 741093008474 cell division protein DedD; Provisional; Region: PRK11633 741093008475 Sporulation related domain; Region: SPOR; pfam05036 741093008476 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 741093008477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741093008478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741093008479 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 741093008480 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 741093008481 hypothetical protein; Provisional; Region: PRK10847 741093008482 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741093008483 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 741093008484 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 741093008485 dimerization interface 3.5A [polypeptide binding]; other site 741093008486 active site 741093008487 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 741093008488 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741093008489 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 741093008490 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 741093008491 ligand binding site [chemical binding]; other site 741093008492 NAD binding site [chemical binding]; other site 741093008493 catalytic site [active] 741093008494 homodimer interface [polypeptide binding]; other site 741093008495 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 741093008496 putative transporter; Provisional; Region: PRK12382 741093008497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008498 putative substrate translocation pore; other site 741093008499 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 741093008500 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741093008501 dimer interface [polypeptide binding]; other site 741093008502 active site 741093008503 Uncharacterized conserved protein [Function unknown]; Region: COG4121 741093008504 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 741093008505 YfcL protein; Region: YfcL; pfam08891 741093008506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 741093008507 hypothetical protein; Provisional; Region: PRK10621 741093008508 Predicted permeases [General function prediction only]; Region: COG0730 741093008509 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 741093008510 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 741093008511 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 741093008512 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 741093008513 Tetramer interface [polypeptide binding]; other site 741093008514 active site 741093008515 FMN-binding site [chemical binding]; other site 741093008516 HemK family putative methylases; Region: hemK_fam; TIGR00536 741093008517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093008518 S-adenosylmethionine binding site [chemical binding]; other site 741093008519 hypothetical protein; Provisional; Region: PRK04946 741093008520 Smr domain; Region: Smr; pfam01713 741093008521 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 741093008522 Fimbrial protein; Region: Fimbrial; cl01416 741093008523 Fimbrial protein; Region: Fimbrial; cl01416 741093008524 Fimbrial protein; Region: Fimbrial; cl01416 741093008525 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093008526 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093008527 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 741093008528 PapC N-terminal domain; Region: PapC_N; pfam13954 741093008529 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093008530 PapC C-terminal domain; Region: PapC_C; pfam13953 741093008531 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093008532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741093008533 catalytic core [active] 741093008534 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 741093008535 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741093008536 substrate binding site [chemical binding]; other site 741093008537 oxyanion hole (OAH) forming residues; other site 741093008538 trimer interface [polypeptide binding]; other site 741093008539 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 741093008540 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741093008541 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 741093008542 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 741093008543 dimer interface [polypeptide binding]; other site 741093008544 active site 741093008545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 741093008546 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 741093008547 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 741093008548 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 741093008549 integrase; Provisional; Region: PRK09692 741093008550 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093008551 active site 741093008552 Int/Topo IB signature motif; other site 741093008553 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 741093008554 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 741093008555 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 741093008556 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 741093008557 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 741093008558 catalytic residues [active] 741093008559 catalytic nucleophile [active] 741093008560 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 741093008561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008562 putative substrate translocation pore; other site 741093008563 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093008564 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 741093008565 putative substrate binding site [chemical binding]; other site 741093008566 putative ATP binding site [chemical binding]; other site 741093008567 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 741093008568 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 741093008569 substrate binding [chemical binding]; other site 741093008570 active site 741093008571 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 741093008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093008573 DNA binding site [nucleotide binding] 741093008574 domain linker motif; other site 741093008575 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 741093008576 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 741093008577 putative dimerization interface [polypeptide binding]; other site 741093008578 putative ligand binding site [chemical binding]; other site 741093008579 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 741093008580 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 741093008581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741093008582 catalytic residue [active] 741093008583 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741093008584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008585 putative substrate translocation pore; other site 741093008586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093008587 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 741093008588 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093008589 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093008590 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 741093008591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093008592 active site 741093008593 phosphorylation site [posttranslational modification] 741093008594 intermolecular recognition site; other site 741093008595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093008596 DNA binding residues [nucleotide binding] 741093008597 dimerization interface [polypeptide binding]; other site 741093008598 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 741093008599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093008600 substrate binding pocket [chemical binding]; other site 741093008601 membrane-bound complex binding site; other site 741093008602 hinge residues; other site 741093008603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093008604 substrate binding pocket [chemical binding]; other site 741093008605 membrane-bound complex binding site; other site 741093008606 hinge residues; other site 741093008607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093008608 dimer interface [polypeptide binding]; other site 741093008609 phosphorylation site [posttranslational modification] 741093008610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093008611 ATP binding site [chemical binding]; other site 741093008612 Mg2+ binding site [ion binding]; other site 741093008613 G-X-G motif; other site 741093008614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093008615 active site 741093008616 phosphorylation site [posttranslational modification] 741093008617 intermolecular recognition site; other site 741093008618 dimerization interface [polypeptide binding]; other site 741093008619 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741093008620 putative binding surface; other site 741093008621 active site 741093008622 CoA-transferase family III; Region: CoA_transf_3; pfam02515 741093008623 putative CoA-transferase; Provisional; Region: PRK11430 741093008624 putative transporter YfdV; Provisional; Region: PRK09903 741093008625 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 741093008626 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741093008627 PYR/PP interface [polypeptide binding]; other site 741093008628 dimer interface [polypeptide binding]; other site 741093008629 TPP binding site [chemical binding]; other site 741093008630 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741093008631 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 741093008632 TPP-binding site; other site 741093008633 dimer interface [polypeptide binding]; other site 741093008634 formyl-coenzyme A transferase; Provisional; Region: PRK05398 741093008635 CoA-transferase family III; Region: CoA_transf_3; pfam02515 741093008636 hypothetical protein; Provisional; Region: PRK10316 741093008637 YfdX protein; Region: YfdX; pfam10938 741093008638 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 741093008639 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741093008640 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741093008641 putative acyl-acceptor binding pocket; other site 741093008642 aminotransferase; Validated; Region: PRK08175 741093008643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093008644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093008645 homodimer interface [polypeptide binding]; other site 741093008646 catalytic residue [active] 741093008647 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 741093008648 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 741093008649 GAF domain; Region: GAF; pfam01590 741093008650 Histidine kinase; Region: His_kinase; pfam06580 741093008651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093008652 ATP binding site [chemical binding]; other site 741093008653 Mg2+ binding site [ion binding]; other site 741093008654 G-X-G motif; other site 741093008655 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 741093008656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093008657 active site 741093008658 phosphorylation site [posttranslational modification] 741093008659 intermolecular recognition site; other site 741093008660 dimerization interface [polypeptide binding]; other site 741093008661 LytTr DNA-binding domain; Region: LytTR; pfam04397 741093008662 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093008663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093008664 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093008665 dimerization domain swap beta strand [polypeptide binding]; other site 741093008666 regulatory protein interface [polypeptide binding]; other site 741093008667 active site 741093008668 regulatory phosphorylation site [posttranslational modification]; other site 741093008669 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741093008670 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 741093008671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741093008672 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741093008673 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093008674 active site 741093008675 phosphorylation site [posttranslational modification] 741093008676 exoaminopeptidase; Provisional; Region: PRK09961 741093008677 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 741093008678 oligomer interface [polypeptide binding]; other site 741093008679 active site 741093008680 metal binding site [ion binding]; metal-binding site 741093008681 aminopeptidase; Provisional; Region: PRK09795 741093008682 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 741093008683 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 741093008684 active site 741093008685 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 741093008686 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741093008687 active site 741093008688 P-loop; other site 741093008689 phosphorylation site [posttranslational modification] 741093008690 glucokinase, proteobacterial type; Region: glk; TIGR00749 741093008691 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093008692 nucleotide binding site [chemical binding]; other site 741093008693 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 741093008694 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 741093008695 Cl- selectivity filter; other site 741093008696 Cl- binding residues [ion binding]; other site 741093008697 pore gating glutamate residue; other site 741093008698 dimer interface [polypeptide binding]; other site 741093008699 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 741093008700 manganese transport protein MntH; Reviewed; Region: PRK00701 741093008701 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 741093008702 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 741093008703 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 741093008704 Nucleoside recognition; Region: Gate; pfam07670 741093008705 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 741093008706 MASE1; Region: MASE1; pfam05231 741093008707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093008708 diguanylate cyclase; Region: GGDEF; smart00267 741093008709 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093008710 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 741093008711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093008712 salt bridge; other site 741093008713 non-specific DNA binding site [nucleotide binding]; other site 741093008714 sequence-specific DNA binding site [nucleotide binding]; other site 741093008715 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 741093008716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 741093008717 Probable transposase; Region: OrfB_IS605; pfam01385 741093008718 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 741093008719 Transposase IS200 like; Region: Y1_Tnp; pfam01797 741093008720 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 741093008721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 741093008722 active site 741093008723 HIGH motif; other site 741093008724 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 741093008725 active site 741093008726 KMSKS motif; other site 741093008727 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 741093008728 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 741093008729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 741093008730 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 741093008731 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 741093008732 nucleotide binding pocket [chemical binding]; other site 741093008733 K-X-D-G motif; other site 741093008734 catalytic site [active] 741093008735 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 741093008736 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 741093008737 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 741093008738 Dimer interface [polypeptide binding]; other site 741093008739 BRCT sequence motif; other site 741093008740 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 741093008741 cell division protein ZipA; Provisional; Region: PRK03427 741093008742 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 741093008743 FtsZ protein binding site [polypeptide binding]; other site 741093008744 putative sulfate transport protein CysZ; Validated; Region: PRK04949 741093008745 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 741093008746 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 741093008747 dimer interface [polypeptide binding]; other site 741093008748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093008749 catalytic residue [active] 741093008750 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093008751 dimerization domain swap beta strand [polypeptide binding]; other site 741093008752 regulatory protein interface [polypeptide binding]; other site 741093008753 active site 741093008754 regulatory phosphorylation site [posttranslational modification]; other site 741093008755 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 741093008756 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741093008757 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741093008758 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741093008759 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 741093008760 HPr interaction site; other site 741093008761 glycerol kinase (GK) interaction site [polypeptide binding]; other site 741093008762 active site 741093008763 phosphorylation site [posttranslational modification] 741093008764 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 741093008765 dimer interface [polypeptide binding]; other site 741093008766 pyridoxamine kinase; Validated; Region: PRK05756 741093008767 pyridoxal binding site [chemical binding]; other site 741093008768 ATP binding site [chemical binding]; other site 741093008769 hypothetical protein; Provisional; Region: PRK10318 741093008770 cysteine synthase B; Region: cysM; TIGR01138 741093008771 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 741093008772 dimer interface [polypeptide binding]; other site 741093008773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093008774 catalytic residue [active] 741093008775 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 741093008776 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 741093008777 Walker A/P-loop; other site 741093008778 ATP binding site [chemical binding]; other site 741093008779 Q-loop/lid; other site 741093008780 ABC transporter signature motif; other site 741093008781 Walker B; other site 741093008782 D-loop; other site 741093008783 H-loop/switch region; other site 741093008784 TOBE-like domain; Region: TOBE_3; pfam12857 741093008785 sulfate transport protein; Provisional; Region: cysT; CHL00187 741093008786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093008787 dimer interface [polypeptide binding]; other site 741093008788 conserved gate region; other site 741093008789 putative PBP binding loops; other site 741093008790 ABC-ATPase subunit interface; other site 741093008791 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 741093008792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093008793 dimer interface [polypeptide binding]; other site 741093008794 conserved gate region; other site 741093008795 putative PBP binding loops; other site 741093008796 ABC-ATPase subunit interface; other site 741093008797 thiosulfate transporter subunit; Provisional; Region: PRK10852 741093008798 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741093008799 short chain dehydrogenase; Provisional; Region: PRK08226 741093008800 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 741093008801 NAD binding site [chemical binding]; other site 741093008802 homotetramer interface [polypeptide binding]; other site 741093008803 homodimer interface [polypeptide binding]; other site 741093008804 active site 741093008805 transcriptional regulator MurR; Provisional; Region: PRK15482 741093008806 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741093008807 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741093008808 putative active site [active] 741093008809 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 741093008810 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 741093008811 putative active site [active] 741093008812 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 741093008813 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093008814 active site turn [active] 741093008815 phosphorylation site [posttranslational modification] 741093008816 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741093008817 putative periplasmic esterase; Provisional; Region: PRK03642 741093008818 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741093008819 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 741093008820 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 741093008821 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 741093008822 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 741093008823 putative acetyltransferase; Provisional; Region: PRK03624 741093008824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093008825 Coenzyme A binding pocket [chemical binding]; other site 741093008826 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 741093008827 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741093008828 active site 741093008829 metal binding site [ion binding]; metal-binding site 741093008830 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 741093008831 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 741093008832 transcriptional regulator EutR; Provisional; Region: PRK10130 741093008833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093008834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093008835 carboxysome structural protein EutK; Provisional; Region: PRK15466 741093008836 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 741093008837 Hexamer interface [polypeptide binding]; other site 741093008838 Hexagonal pore residue; other site 741093008839 FaeA-like protein; Region: FaeA; pfam04703 741093008840 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 741093008841 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 741093008842 putative hexamer interface [polypeptide binding]; other site 741093008843 putative hexagonal pore; other site 741093008844 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 741093008845 putative hexamer interface [polypeptide binding]; other site 741093008846 putative hexagonal pore; other site 741093008847 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 741093008848 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 741093008849 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 741093008850 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 741093008851 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 741093008852 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 741093008853 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 741093008854 active site 741093008855 metal binding site [ion binding]; metal-binding site 741093008856 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 741093008857 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093008858 nucleotide binding site [chemical binding]; other site 741093008859 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 741093008860 putative catalytic cysteine [active] 741093008861 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 741093008862 Hexamer/Pentamer interface [polypeptide binding]; other site 741093008863 central pore; other site 741093008864 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 741093008865 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 741093008866 Hexamer interface [polypeptide binding]; other site 741093008867 Putative hexagonal pore residue; other site 741093008868 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 741093008869 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 741093008870 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 741093008871 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 741093008872 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 741093008873 G1 box; other site 741093008874 GTP/Mg2+ binding site [chemical binding]; other site 741093008875 G2 box; other site 741093008876 Switch I region; other site 741093008877 G3 box; other site 741093008878 Switch II region; other site 741093008879 G4 box; other site 741093008880 G5 box; other site 741093008881 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 741093008882 putative hexamer interface [polypeptide binding]; other site 741093008883 putative hexagonal pore; other site 741093008884 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 741093008885 Malic enzyme, N-terminal domain; Region: malic; pfam00390 741093008886 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 741093008887 putative NAD(P) binding site [chemical binding]; other site 741093008888 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 741093008889 transaldolase-like protein; Provisional; Region: PTZ00411 741093008890 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 741093008891 active site 741093008892 dimer interface [polypeptide binding]; other site 741093008893 catalytic residue [active] 741093008894 transketolase; Reviewed; Region: PRK12753 741093008895 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 741093008896 TPP-binding site [chemical binding]; other site 741093008897 dimer interface [polypeptide binding]; other site 741093008898 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741093008899 PYR/PP interface [polypeptide binding]; other site 741093008900 dimer interface [polypeptide binding]; other site 741093008901 TPP binding site [chemical binding]; other site 741093008902 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741093008903 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 741093008904 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 741093008905 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 741093008906 dimer interface [polypeptide binding]; other site 741093008907 ADP-ribose binding site [chemical binding]; other site 741093008908 active site 741093008909 nudix motif; other site 741093008910 metal binding site [ion binding]; metal-binding site 741093008911 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 741093008912 4Fe-4S binding domain; Region: Fer4; pfam00037 741093008913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093008914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093008915 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 741093008916 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 741093008917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093008918 dimerization interface [polypeptide binding]; other site 741093008919 Histidine kinase; Region: HisKA_3; pfam07730 741093008920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093008921 ATP binding site [chemical binding]; other site 741093008922 Mg2+ binding site [ion binding]; other site 741093008923 G-X-G motif; other site 741093008924 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 741093008925 Protein export membrane protein; Region: SecD_SecF; cl14618 741093008926 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 741093008927 ArsC family; Region: ArsC; pfam03960 741093008928 putative catalytic residues [active] 741093008929 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 741093008930 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 741093008931 metal binding site [ion binding]; metal-binding site 741093008932 dimer interface [polypeptide binding]; other site 741093008933 hypothetical protein; Provisional; Region: PRK13664 741093008934 putative hydrolase; Provisional; Region: PRK11460 741093008935 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 741093008936 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 741093008937 Helicase; Region: Helicase_RecD; pfam05127 741093008938 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 741093008939 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 741093008940 Predicted metalloprotease [General function prediction only]; Region: COG2321 741093008941 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 741093008942 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 741093008943 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 741093008944 ATP binding site [chemical binding]; other site 741093008945 active site 741093008946 substrate binding site [chemical binding]; other site 741093008947 lipoprotein; Provisional; Region: PRK11679 741093008948 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 741093008949 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 741093008950 dihydrodipicolinate synthase; Region: dapA; TIGR00674 741093008951 dimer interface [polypeptide binding]; other site 741093008952 active site 741093008953 catalytic residue [active] 741093008954 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 741093008955 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 741093008956 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 741093008957 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 741093008958 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 741093008959 catalytic triad [active] 741093008960 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 741093008961 4Fe-4S binding domain; Region: Fer4; pfam00037 741093008962 hydrogenase 4 subunit B; Validated; Region: PRK06521 741093008963 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093008964 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 741093008965 NADH dehydrogenase; Region: NADHdh; cl00469 741093008966 hydrogenase 4 subunit D; Validated; Region: PRK06525 741093008967 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093008968 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 741093008969 hydrogenase 4 subunit F; Validated; Region: PRK06458 741093008970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093008971 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 741093008972 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 741093008973 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 741093008974 hydrogenase 4 subunit H; Validated; Region: PRK08222 741093008975 4Fe-4S binding domain; Region: Fer4; pfam00037 741093008976 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 741093008977 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 741093008978 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 741093008979 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741093008980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093008981 Walker A motif; other site 741093008982 ATP binding site [chemical binding]; other site 741093008983 Walker B motif; other site 741093008984 arginine finger; other site 741093008985 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741093008986 putative formate transporter; Provisional; Region: focB; PRK09713 741093008987 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 741093008988 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741093008989 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 741093008990 Peptidase family M48; Region: Peptidase_M48; cl12018 741093008991 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 741093008992 ArsC family; Region: ArsC; pfam03960 741093008993 catalytic residues [active] 741093008994 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 741093008995 DNA replication initiation factor; Provisional; Region: PRK08084 741093008996 uracil transporter; Provisional; Region: PRK10720 741093008997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093008998 active site 741093008999 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 741093009000 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 741093009001 dimerization interface [polypeptide binding]; other site 741093009002 putative ATP binding site [chemical binding]; other site 741093009003 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 741093009004 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 741093009005 active site 741093009006 substrate binding site [chemical binding]; other site 741093009007 cosubstrate binding site; other site 741093009008 catalytic site [active] 741093009009 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 741093009010 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 741093009011 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 741093009012 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 741093009013 domain interface [polypeptide binding]; other site 741093009014 active site 741093009015 catalytic site [active] 741093009016 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 741093009017 putative active site [active] 741093009018 catalytic site [active] 741093009019 exopolyphosphatase; Provisional; Region: PRK10854 741093009020 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 741093009021 MASE1; Region: MASE1; pfam05231 741093009022 diguanylate cyclase; Region: GGDEF; smart00267 741093009023 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741093009024 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093009025 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 741093009026 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 741093009027 GMP synthase; Reviewed; Region: guaA; PRK00074 741093009028 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 741093009029 AMP/PPi binding site [chemical binding]; other site 741093009030 candidate oxyanion hole; other site 741093009031 catalytic triad [active] 741093009032 potential glutamine specificity residues [chemical binding]; other site 741093009033 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 741093009034 ATP Binding subdomain [chemical binding]; other site 741093009035 Ligand Binding sites [chemical binding]; other site 741093009036 Dimerization subdomain; other site 741093009037 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 741093009038 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741093009039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 741093009040 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 741093009041 active site 741093009042 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 741093009043 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 741093009044 generic binding surface II; other site 741093009045 generic binding surface I; other site 741093009046 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 741093009047 GTP-binding protein Der; Reviewed; Region: PRK00093 741093009048 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 741093009049 G1 box; other site 741093009050 GTP/Mg2+ binding site [chemical binding]; other site 741093009051 Switch I region; other site 741093009052 G2 box; other site 741093009053 Switch II region; other site 741093009054 G3 box; other site 741093009055 G4 box; other site 741093009056 G5 box; other site 741093009057 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 741093009058 G1 box; other site 741093009059 GTP/Mg2+ binding site [chemical binding]; other site 741093009060 Switch I region; other site 741093009061 G2 box; other site 741093009062 G3 box; other site 741093009063 Switch II region; other site 741093009064 G4 box; other site 741093009065 G5 box; other site 741093009066 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 741093009067 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 741093009068 Trp docking motif [polypeptide binding]; other site 741093009069 active site 741093009070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 741093009071 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 741093009072 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 741093009073 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 741093009074 dimer interface [polypeptide binding]; other site 741093009075 motif 1; other site 741093009076 active site 741093009077 motif 2; other site 741093009078 motif 3; other site 741093009079 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 741093009080 anticodon binding site; other site 741093009081 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 741093009082 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 741093009083 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 741093009084 cytoskeletal protein RodZ; Provisional; Region: PRK10856 741093009085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093009086 non-specific DNA binding site [nucleotide binding]; other site 741093009087 salt bridge; other site 741093009088 sequence-specific DNA binding site [nucleotide binding]; other site 741093009089 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 741093009090 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 741093009091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093009092 FeS/SAM binding site; other site 741093009093 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 741093009094 active site 741093009095 multimer interface [polypeptide binding]; other site 741093009096 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 741093009097 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 741093009098 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 741093009099 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 741093009100 4Fe-4S binding domain; Region: Fer4; pfam00037 741093009101 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 741093009102 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741093009103 putative [Fe4-S4] binding site [ion binding]; other site 741093009104 putative molybdopterin cofactor binding site [chemical binding]; other site 741093009105 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741093009106 putative molybdopterin cofactor binding site; other site 741093009107 penicillin-binding protein 1C; Provisional; Region: PRK11240 741093009108 Transglycosylase; Region: Transgly; pfam00912 741093009109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 741093009110 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 741093009111 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 741093009112 MG2 domain; Region: A2M_N; pfam01835 741093009113 Alpha-2-macroglobulin family; Region: A2M; pfam00207 741093009114 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 741093009115 surface patch; other site 741093009116 thioester region; other site 741093009117 specificity defining residues; other site 741093009118 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 741093009119 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 741093009120 active site residue [active] 741093009121 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 741093009122 active site residue [active] 741093009123 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 741093009124 aminopeptidase B; Provisional; Region: PRK05015 741093009125 Peptidase; Region: DUF3663; pfam12404 741093009126 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 741093009127 interface (dimer of trimers) [polypeptide binding]; other site 741093009128 Substrate-binding/catalytic site; other site 741093009129 Zn-binding sites [ion binding]; other site 741093009130 hypothetical protein; Provisional; Region: PRK10721 741093009131 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 741093009132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093009133 catalytic loop [active] 741093009134 iron binding site [ion binding]; other site 741093009135 chaperone protein HscA; Provisional; Region: hscA; PRK05183 741093009136 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 741093009137 nucleotide binding site [chemical binding]; other site 741093009138 putative NEF/HSP70 interaction site [polypeptide binding]; other site 741093009139 SBD interface [polypeptide binding]; other site 741093009140 co-chaperone HscB; Provisional; Region: hscB; PRK05014 741093009141 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 741093009142 HSP70 interaction site [polypeptide binding]; other site 741093009143 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 741093009144 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 741093009145 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 741093009146 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 741093009147 trimerization site [polypeptide binding]; other site 741093009148 active site 741093009149 cysteine desulfurase; Provisional; Region: PRK14012 741093009150 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 741093009151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741093009152 catalytic residue [active] 741093009153 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 741093009154 Rrf2 family protein; Region: rrf2_super; TIGR00738 741093009155 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 741093009156 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 741093009157 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 741093009158 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 741093009159 active site 741093009160 dimerization interface [polypeptide binding]; other site 741093009161 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 741093009162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741093009163 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 741093009164 PRD domain; Region: PRD; pfam00874 741093009165 PRD domain; Region: PRD; pfam00874 741093009166 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 741093009167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009168 putative substrate translocation pore; other site 741093009169 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 741093009170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093009171 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 741093009172 putative dimerization interface [polypeptide binding]; other site 741093009173 putative substrate binding pocket [chemical binding]; other site 741093009174 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 741093009175 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 741093009176 iron-sulfur cluster [ion binding]; other site 741093009177 [2Fe-2S] cluster binding site [ion binding]; other site 741093009178 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 741093009179 beta subunit interface [polypeptide binding]; other site 741093009180 alpha subunit interface [polypeptide binding]; other site 741093009181 active site 741093009182 substrate binding site [chemical binding]; other site 741093009183 Fe binding site [ion binding]; other site 741093009184 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 741093009185 inter-subunit interface; other site 741093009186 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 741093009187 [2Fe-2S] cluster binding site [ion binding]; other site 741093009188 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 741093009189 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 741093009190 NAD binding site [chemical binding]; other site 741093009191 active site 741093009192 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 741093009193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093009194 Predicted membrane protein [Function unknown]; Region: COG2259 741093009195 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 741093009196 active site 741093009197 catalytic residues [active] 741093009198 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093009199 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093009200 TM-ABC transporter signature motif; other site 741093009201 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741093009202 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093009203 Walker A/P-loop; other site 741093009204 ATP binding site [chemical binding]; other site 741093009205 Q-loop/lid; other site 741093009206 ABC transporter signature motif; other site 741093009207 Walker B; other site 741093009208 D-loop; other site 741093009209 H-loop/switch region; other site 741093009210 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093009211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 741093009212 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 741093009213 ligand binding site [chemical binding]; other site 741093009214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093009215 TPR motif; other site 741093009216 Tetratricopeptide repeat; Region: TPR_16; pfam13432 741093009217 binding surface 741093009218 TPR repeat; Region: TPR_11; pfam13414 741093009219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093009220 TPR motif; other site 741093009221 binding surface 741093009222 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 741093009223 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741093009224 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093009225 nucleotide binding site [chemical binding]; other site 741093009226 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 741093009227 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 741093009228 dimer interface [polypeptide binding]; other site 741093009229 active site 741093009230 glycine-pyridoxal phosphate binding site [chemical binding]; other site 741093009231 folate binding site [chemical binding]; other site 741093009232 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 741093009233 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 741093009234 heme-binding site [chemical binding]; other site 741093009235 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 741093009236 FAD binding pocket [chemical binding]; other site 741093009237 FAD binding motif [chemical binding]; other site 741093009238 phosphate binding motif [ion binding]; other site 741093009239 beta-alpha-beta structure motif; other site 741093009240 NAD binding pocket [chemical binding]; other site 741093009241 Heme binding pocket [chemical binding]; other site 741093009242 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 741093009243 Nitrogen regulatory protein P-II; Region: P-II; smart00938 741093009244 response regulator GlrR; Provisional; Region: PRK15115 741093009245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093009246 active site 741093009247 phosphorylation site [posttranslational modification] 741093009248 intermolecular recognition site; other site 741093009249 dimerization interface [polypeptide binding]; other site 741093009250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093009251 Walker A motif; other site 741093009252 ATP binding site [chemical binding]; other site 741093009253 Walker B motif; other site 741093009254 arginine finger; other site 741093009255 hypothetical protein; Provisional; Region: PRK10722 741093009256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 741093009257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093009258 dimer interface [polypeptide binding]; other site 741093009259 phosphorylation site [posttranslational modification] 741093009260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093009261 ATP binding site [chemical binding]; other site 741093009262 Mg2+ binding site [ion binding]; other site 741093009263 G-X-G motif; other site 741093009264 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 741093009265 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 741093009266 dimerization interface [polypeptide binding]; other site 741093009267 ATP binding site [chemical binding]; other site 741093009268 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 741093009269 dimerization interface [polypeptide binding]; other site 741093009270 ATP binding site [chemical binding]; other site 741093009271 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 741093009272 putative active site [active] 741093009273 catalytic triad [active] 741093009274 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 741093009275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093009276 substrate binding pocket [chemical binding]; other site 741093009277 membrane-bound complex binding site; other site 741093009278 hinge residues; other site 741093009279 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093009280 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093009281 catalytic residue [active] 741093009282 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 741093009283 nucleoside/Zn binding site; other site 741093009284 dimer interface [polypeptide binding]; other site 741093009285 catalytic motif [active] 741093009286 hypothetical protein; Provisional; Region: PRK11590 741093009287 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 741093009288 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741093009289 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 741093009290 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741093009291 putative active site [active] 741093009292 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 741093009293 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 741093009294 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 741093009295 active site 741093009296 hydrophilic channel; other site 741093009297 dimerization interface [polypeptide binding]; other site 741093009298 catalytic residues [active] 741093009299 active site lid [active] 741093009300 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 741093009301 Recombination protein O N terminal; Region: RecO_N; pfam11967 741093009302 Recombination protein O C terminal; Region: RecO_C; pfam02565 741093009303 GTPase Era; Reviewed; Region: era; PRK00089 741093009304 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 741093009305 G1 box; other site 741093009306 GTP/Mg2+ binding site [chemical binding]; other site 741093009307 Switch I region; other site 741093009308 G2 box; other site 741093009309 Switch II region; other site 741093009310 G3 box; other site 741093009311 G4 box; other site 741093009312 G5 box; other site 741093009313 KH domain; Region: KH_2; pfam07650 741093009314 ribonuclease III; Reviewed; Region: rnc; PRK00102 741093009315 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 741093009316 dimerization interface [polypeptide binding]; other site 741093009317 active site 741093009318 metal binding site [ion binding]; metal-binding site 741093009319 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 741093009320 dsRNA binding site [nucleotide binding]; other site 741093009321 signal peptidase I; Provisional; Region: PRK10861 741093009322 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 741093009323 Catalytic site [active] 741093009324 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 741093009325 GTP-binding protein LepA; Provisional; Region: PRK05433 741093009326 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 741093009327 G1 box; other site 741093009328 putative GEF interaction site [polypeptide binding]; other site 741093009329 GTP/Mg2+ binding site [chemical binding]; other site 741093009330 Switch I region; other site 741093009331 G2 box; other site 741093009332 G3 box; other site 741093009333 Switch II region; other site 741093009334 G4 box; other site 741093009335 G5 box; other site 741093009336 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 741093009337 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 741093009338 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 741093009339 SoxR reducing system protein RseC; Provisional; Region: PRK10862 741093009340 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 741093009341 anti-sigma E factor; Provisional; Region: rseB; PRK09455 741093009342 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 741093009343 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 741093009344 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 741093009345 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 741093009346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741093009347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741093009348 DNA binding residues [nucleotide binding] 741093009349 L-aspartate oxidase; Provisional; Region: PRK09077 741093009350 L-aspartate oxidase; Provisional; Region: PRK06175 741093009351 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 741093009352 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 741093009353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093009354 S-adenosylmethionine binding site [chemical binding]; other site 741093009355 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 741093009356 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741093009357 ATP binding site [chemical binding]; other site 741093009358 Mg++ binding site [ion binding]; other site 741093009359 motif III; other site 741093009360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093009361 nucleotide binding region [chemical binding]; other site 741093009362 ATP-binding site [chemical binding]; other site 741093009363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093009364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093009365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741093009366 dimerization interface [polypeptide binding]; other site 741093009367 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 741093009368 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 741093009369 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 741093009370 ligand binding site [chemical binding]; other site 741093009371 active site 741093009372 UGI interface [polypeptide binding]; other site 741093009373 catalytic site [active] 741093009374 putative methyltransferase; Provisional; Region: PRK10864 741093009375 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 741093009376 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 741093009377 thioredoxin 2; Provisional; Region: PRK10996 741093009378 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 741093009379 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 741093009380 catalytic residues [active] 741093009381 Uncharacterized conserved protein [Function unknown]; Region: COG3148 741093009382 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 741093009383 CoA binding domain; Region: CoA_binding_2; pfam13380 741093009384 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 741093009385 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 741093009386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741093009387 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741093009388 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 741093009389 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 741093009390 domain interface [polypeptide binding]; other site 741093009391 putative active site [active] 741093009392 catalytic site [active] 741093009393 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 741093009394 domain interface [polypeptide binding]; other site 741093009395 putative active site [active] 741093009396 catalytic site [active] 741093009397 lipoprotein; Provisional; Region: PRK10759 741093009398 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 741093009399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009400 putative substrate translocation pore; other site 741093009401 protein disaggregation chaperone; Provisional; Region: PRK10865 741093009402 Clp amino terminal domain; Region: Clp_N; pfam02861 741093009403 Clp amino terminal domain; Region: Clp_N; pfam02861 741093009404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093009405 Walker A motif; other site 741093009406 ATP binding site [chemical binding]; other site 741093009407 Walker B motif; other site 741093009408 arginine finger; other site 741093009409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093009410 Walker A motif; other site 741093009411 ATP binding site [chemical binding]; other site 741093009412 Walker B motif; other site 741093009413 arginine finger; other site 741093009414 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 741093009415 hypothetical protein; Provisional; Region: PRK10723 741093009416 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 741093009417 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 741093009418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093009419 RNA binding surface [nucleotide binding]; other site 741093009420 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741093009421 active site 741093009422 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 741093009423 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 741093009424 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 741093009425 30S subunit binding site; other site 741093009426 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 741093009427 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 741093009428 Prephenate dehydratase; Region: PDT; pfam00800 741093009429 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 741093009430 putative L-Phe binding site [chemical binding]; other site 741093009431 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 741093009432 Chorismate mutase type II; Region: CM_2; cl00693 741093009433 prephenate dehydrogenase; Validated; Region: PRK08507 741093009434 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 741093009435 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741093009436 lipoprotein; Provisional; Region: PRK11443 741093009437 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 741093009438 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 741093009439 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 741093009440 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093009441 metal binding site [ion binding]; metal-binding site 741093009442 active site 741093009443 I-site; other site 741093009444 putative outer membrane lipoprotein; Provisional; Region: PRK09967 741093009445 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093009446 ligand binding site [chemical binding]; other site 741093009447 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 741093009448 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 741093009449 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 741093009450 RimM N-terminal domain; Region: RimM; pfam01782 741093009451 PRC-barrel domain; Region: PRC; pfam05239 741093009452 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 741093009453 signal recognition particle protein; Provisional; Region: PRK10867 741093009454 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 741093009455 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 741093009456 P loop; other site 741093009457 GTP binding site [chemical binding]; other site 741093009458 Signal peptide binding domain; Region: SRP_SPB; pfam02978 741093009459 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 741093009460 hypothetical protein; Provisional; Region: PRK11573 741093009461 Domain of unknown function DUF21; Region: DUF21; pfam01595 741093009462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741093009463 Transporter associated domain; Region: CorC_HlyC; smart01091 741093009464 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 741093009465 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 741093009466 dimer interface [polypeptide binding]; other site 741093009467 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 741093009468 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 741093009469 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 741093009470 recombination and repair protein; Provisional; Region: PRK10869 741093009471 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 741093009472 Walker A/P-loop; other site 741093009473 ATP binding site [chemical binding]; other site 741093009474 Q-loop/lid; other site 741093009475 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 741093009476 Q-loop/lid; other site 741093009477 ABC transporter signature motif; other site 741093009478 Walker B; other site 741093009479 D-loop; other site 741093009480 H-loop/switch region; other site 741093009481 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 741093009482 hypothetical protein; Validated; Region: PRK01777 741093009483 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 741093009484 putative coenzyme Q binding site [chemical binding]; other site 741093009485 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 741093009486 SmpB-tmRNA interface; other site 741093009487 DinI-like family; Region: DinI; pfam06183 741093009488 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 741093009489 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093009490 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 741093009491 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 741093009492 Transposase; Region: HTH_Tnp_1; cl17663 741093009493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093009494 putative transposase OrfB; Reviewed; Region: PHA02517 741093009495 HTH-like domain; Region: HTH_21; pfam13276 741093009496 Integrase core domain; Region: rve; pfam00665 741093009497 Integrase core domain; Region: rve_3; pfam13683 741093009498 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093009499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093009500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093009501 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093009502 Transposase; Region: HTH_Tnp_1; pfam01527 741093009503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093009504 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 741093009505 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 741093009506 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093009507 Antitermination protein; Region: Antiterm; pfam03589 741093009508 Antitermination protein; Region: Antiterm; pfam03589 741093009509 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 741093009510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741093009511 active site 741093009512 metal binding site [ion binding]; metal-binding site 741093009513 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 741093009514 HNH endonuclease; Region: HNH_3; pfam13392 741093009515 AP2 domain; Region: AP2; pfam00847 741093009516 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 741093009517 DNA-binding interface [nucleotide binding]; DNA binding site 741093009518 Helix-turn-helix domain; Region: HTH_38; pfam13936 741093009519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 741093009520 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 741093009521 active site 741093009522 catalytic residues [active] 741093009523 DNA binding site [nucleotide binding] 741093009524 Int/Topo IB signature motif; other site 741093009525 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 741093009526 active site 741093009527 catalytic residues [active] 741093009528 DNA binding site [nucleotide binding] 741093009529 Int/Topo IB signature motif; other site 741093009530 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 741093009531 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 741093009532 hypothetical protein; Provisional; Region: PRK09945 741093009533 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 741093009534 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093009535 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093009536 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 741093009537 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 741093009538 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 741093009539 active site 741093009540 catalytic site [active] 741093009541 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 741093009542 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 741093009543 substrate binding pocket [chemical binding]; other site 741093009544 active site 741093009545 iron coordination sites [ion binding]; other site 741093009546 Predicted dehydrogenase [General function prediction only]; Region: COG0579 741093009547 hydroxyglutarate oxidase; Provisional; Region: PRK11728 741093009548 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 741093009549 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 741093009550 tetramerization interface [polypeptide binding]; other site 741093009551 NAD(P) binding site [chemical binding]; other site 741093009552 catalytic residues [active] 741093009553 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 741093009554 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093009555 inhibitor-cofactor binding pocket; inhibition site 741093009556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093009557 catalytic residue [active] 741093009558 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 741093009559 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 741093009560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093009561 DNA-binding site [nucleotide binding]; DNA binding site 741093009562 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741093009563 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 741093009564 bacterial OsmY and nodulation domain; Region: BON; smart00749 741093009565 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093009566 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 741093009567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093009568 dimerization interface [polypeptide binding]; other site 741093009569 putative DNA binding site [nucleotide binding]; other site 741093009570 Transcriptional regulators [Transcription]; Region: MarR; COG1846 741093009571 putative Zn2+ binding site [ion binding]; other site 741093009572 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 741093009573 active site residue [active] 741093009574 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 741093009575 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 741093009576 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 741093009577 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 741093009578 hypothetical protein; Provisional; Region: PRK10556 741093009579 hypothetical protein; Provisional; Region: PRK10132 741093009580 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741093009581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093009582 DNA-binding site [nucleotide binding]; DNA binding site 741093009583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093009584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093009585 homodimer interface [polypeptide binding]; other site 741093009586 catalytic residue [active] 741093009587 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 741093009588 Uncharacterized conserved protein [Function unknown]; Region: COG2128 741093009589 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 741093009590 catalytic residues [active] 741093009591 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 741093009592 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 741093009593 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 741093009594 Class I ribonucleotide reductase; Region: RNR_I; cd01679 741093009595 active site 741093009596 dimer interface [polypeptide binding]; other site 741093009597 catalytic residues [active] 741093009598 effector binding site; other site 741093009599 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 741093009600 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 741093009601 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 741093009602 dimer interface [polypeptide binding]; other site 741093009603 putative radical transfer pathway; other site 741093009604 diiron center [ion binding]; other site 741093009605 tyrosyl radical; other site 741093009606 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 741093009607 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 741093009608 Walker A/P-loop; other site 741093009609 ATP binding site [chemical binding]; other site 741093009610 Q-loop/lid; other site 741093009611 ABC transporter signature motif; other site 741093009612 Walker B; other site 741093009613 D-loop; other site 741093009614 H-loop/switch region; other site 741093009615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 741093009616 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 741093009617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093009618 dimer interface [polypeptide binding]; other site 741093009619 conserved gate region; other site 741093009620 putative PBP binding loops; other site 741093009621 ABC-ATPase subunit interface; other site 741093009622 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 741093009623 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 741093009624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741093009625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009626 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 741093009627 putative L-valine exporter; Provisional; Region: PRK10408 741093009628 transcriptional repressor MprA; Provisional; Region: PRK10870 741093009629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 741093009630 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 741093009631 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093009632 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093009633 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741093009634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009635 putative substrate translocation pore; other site 741093009636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009637 S-ribosylhomocysteinase; Provisional; Region: PRK02260 741093009638 glutamate--cysteine ligase; Provisional; Region: PRK02107 741093009639 Predicted membrane protein [Function unknown]; Region: COG1238 741093009640 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 741093009641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093009642 motif II; other site 741093009643 carbon storage regulator; Provisional; Region: PRK01712 741093009644 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 741093009645 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 741093009646 motif 1; other site 741093009647 active site 741093009648 motif 2; other site 741093009649 motif 3; other site 741093009650 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 741093009651 DHHA1 domain; Region: DHHA1; pfam02272 741093009652 recombination regulator RecX; Reviewed; Region: recX; PRK00117 741093009653 recombinase A; Provisional; Region: recA; PRK09354 741093009654 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 741093009655 hexamer interface [polypeptide binding]; other site 741093009656 Walker A motif; other site 741093009657 ATP binding site [chemical binding]; other site 741093009658 Walker B motif; other site 741093009659 hypothetical protein; Validated; Region: PRK03661 741093009660 Transglycosylase SLT domain; Region: SLT_2; pfam13406 741093009661 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093009662 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093009663 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 741093009664 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 741093009665 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 741093009666 putative NAD(P) binding site [chemical binding]; other site 741093009667 active site 741093009668 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 741093009669 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 741093009670 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741093009671 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093009672 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 741093009673 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 741093009674 putative active site [active] 741093009675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 741093009676 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 741093009677 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741093009678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093009679 Walker A motif; other site 741093009680 ATP binding site [chemical binding]; other site 741093009681 Walker B motif; other site 741093009682 arginine finger; other site 741093009683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 741093009684 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 741093009685 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 741093009686 Rubredoxin [Energy production and conversion]; Region: COG1773 741093009687 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 741093009688 iron binding site [ion binding]; other site 741093009689 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 741093009690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093009691 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 741093009692 Acylphosphatase; Region: Acylphosphatase; pfam00708 741093009693 HypF finger; Region: zf-HYPF; pfam07503 741093009694 HypF finger; Region: zf-HYPF; pfam07503 741093009695 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 741093009696 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 741093009697 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 741093009698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741093009699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093009700 DNA binding site [nucleotide binding] 741093009701 domain linker motif; other site 741093009702 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 741093009703 dimerization interface (closed form) [polypeptide binding]; other site 741093009704 ligand binding site [chemical binding]; other site 741093009705 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 741093009706 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093009707 active site turn [active] 741093009708 phosphorylation site [posttranslational modification] 741093009709 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 741093009710 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 741093009711 beta-galactosidase; Region: BGL; TIGR03356 741093009712 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 741093009713 nickel binding site [ion binding]; other site 741093009714 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 741093009715 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 741093009716 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 741093009717 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741093009718 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 741093009719 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 741093009720 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 741093009721 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 741093009722 NADH dehydrogenase; Region: NADHdh; cl00469 741093009723 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 741093009724 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741093009725 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 741093009726 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 741093009727 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 741093009728 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 741093009729 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 741093009730 hydrogenase assembly chaperone; Provisional; Region: PRK10409 741093009731 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 741093009732 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 741093009733 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 741093009734 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 741093009735 dimerization interface [polypeptide binding]; other site 741093009736 ATP binding site [chemical binding]; other site 741093009737 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 741093009738 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741093009739 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741093009740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093009741 Walker A motif; other site 741093009742 ATP binding site [chemical binding]; other site 741093009743 Walker B motif; other site 741093009744 arginine finger; other site 741093009745 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 741093009746 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 741093009747 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 741093009748 MutS domain I; Region: MutS_I; pfam01624 741093009749 MutS domain II; Region: MutS_II; pfam05188 741093009750 MutS domain III; Region: MutS_III; pfam05192 741093009751 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 741093009752 Walker A/P-loop; other site 741093009753 ATP binding site [chemical binding]; other site 741093009754 Q-loop/lid; other site 741093009755 ABC transporter signature motif; other site 741093009756 Walker B; other site 741093009757 D-loop; other site 741093009758 H-loop/switch region; other site 741093009759 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 741093009760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741093009761 active site 741093009762 metal binding site [ion binding]; metal-binding site 741093009763 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 741093009764 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 741093009765 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 741093009766 Flavoprotein; Region: Flavoprotein; pfam02441 741093009767 MarR family; Region: MarR_2; cl17246 741093009768 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 741093009769 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 741093009770 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 741093009771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741093009772 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 741093009773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741093009774 DNA binding residues [nucleotide binding] 741093009775 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 741093009776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093009777 Peptidase family M23; Region: Peptidase_M23; pfam01551 741093009778 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 741093009779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093009780 S-adenosylmethionine binding site [chemical binding]; other site 741093009781 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 741093009782 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 741093009783 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 741093009784 Permutation of conserved domain; other site 741093009785 active site 741093009786 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 741093009787 homotrimer interaction site [polypeptide binding]; other site 741093009788 zinc binding site [ion binding]; other site 741093009789 CDP-binding sites; other site 741093009790 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 741093009791 substrate binding site; other site 741093009792 dimer interface; other site 741093009793 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 741093009794 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 741093009795 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 741093009796 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 741093009797 ligand-binding site [chemical binding]; other site 741093009798 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 741093009799 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 741093009800 CysD dimerization site [polypeptide binding]; other site 741093009801 G1 box; other site 741093009802 putative GEF interaction site [polypeptide binding]; other site 741093009803 GTP/Mg2+ binding site [chemical binding]; other site 741093009804 Switch I region; other site 741093009805 G2 box; other site 741093009806 G3 box; other site 741093009807 Switch II region; other site 741093009808 G4 box; other site 741093009809 G5 box; other site 741093009810 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 741093009811 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 741093009812 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 741093009813 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 741093009814 Active Sites [active] 741093009815 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 741093009816 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 741093009817 metal binding site [ion binding]; metal-binding site 741093009818 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 741093009819 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 741093009820 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 741093009821 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 741093009822 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 741093009823 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 741093009824 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 741093009825 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 741093009826 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 741093009827 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 741093009828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 741093009829 Hok/gef family; Region: HOK_GEF; pfam01848 741093009830 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 741093009831 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 741093009832 Active Sites [active] 741093009833 sulfite reductase subunit beta; Provisional; Region: PRK13504 741093009834 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741093009835 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741093009836 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 741093009837 Flavodoxin; Region: Flavodoxin_1; pfam00258 741093009838 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 741093009839 FAD binding pocket [chemical binding]; other site 741093009840 FAD binding motif [chemical binding]; other site 741093009841 catalytic residues [active] 741093009842 NAD binding pocket [chemical binding]; other site 741093009843 phosphate binding motif [ion binding]; other site 741093009844 beta-alpha-beta structure motif; other site 741093009845 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 741093009846 homohexamer interface [polypeptide binding]; other site 741093009847 putative substrate stabilizing pore; other site 741093009848 pterin binding site; other site 741093009849 putative oxidoreductase FixC; Provisional; Region: PRK10157 741093009850 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 741093009851 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 741093009852 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 741093009853 Ligand binding site [chemical binding]; other site 741093009854 Electron transfer flavoprotein domain; Region: ETF; pfam01012 741093009855 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 741093009856 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 741093009857 FAD binding domain; Region: FAD_binding_4; pfam01565 741093009858 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 741093009859 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 741093009860 NADP binding site [chemical binding]; other site 741093009861 homodimer interface [polypeptide binding]; other site 741093009862 active site 741093009863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093009864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009865 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 741093009866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 741093009867 nucleotide binding site [chemical binding]; other site 741093009868 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 741093009869 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 741093009870 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 741093009871 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 741093009872 Repair protein; Region: Repair_PSII; pfam04536 741093009873 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 741093009874 Repair protein; Region: Repair_PSII; pfam04536 741093009875 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 741093009876 Repair protein; Region: Repair_PSII; pfam04536 741093009877 enolase; Provisional; Region: eno; PRK00077 741093009878 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 741093009879 dimer interface [polypeptide binding]; other site 741093009880 metal binding site [ion binding]; metal-binding site 741093009881 substrate binding pocket [chemical binding]; other site 741093009882 CTP synthetase; Validated; Region: pyrG; PRK05380 741093009883 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 741093009884 Catalytic site [active] 741093009885 active site 741093009886 UTP binding site [chemical binding]; other site 741093009887 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 741093009888 active site 741093009889 putative oxyanion hole; other site 741093009890 catalytic triad [active] 741093009891 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 741093009892 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 741093009893 homodimer interface [polypeptide binding]; other site 741093009894 metal binding site [ion binding]; metal-binding site 741093009895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 741093009896 homodimer interface [polypeptide binding]; other site 741093009897 active site 741093009898 putative chemical substrate binding site [chemical binding]; other site 741093009899 metal binding site [ion binding]; metal-binding site 741093009900 toxin MazF; Provisional; Region: PRK09907 741093009901 antitoxin MazE; Provisional; Region: PRK09798 741093009902 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 741093009903 HD domain; Region: HD_4; pfam13328 741093009904 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 741093009905 synthetase active site [active] 741093009906 NTP binding site [chemical binding]; other site 741093009907 metal binding site [ion binding]; metal-binding site 741093009908 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 741093009909 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 741093009910 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 741093009911 TRAM domain; Region: TRAM; pfam01938 741093009912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093009913 S-adenosylmethionine binding site [chemical binding]; other site 741093009914 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 741093009915 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 741093009916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093009917 dimerization interface [polypeptide binding]; other site 741093009918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093009919 dimer interface [polypeptide binding]; other site 741093009920 phosphorylation site [posttranslational modification] 741093009921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093009922 ATP binding site [chemical binding]; other site 741093009923 Mg2+ binding site [ion binding]; other site 741093009924 G-X-G motif; other site 741093009925 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 741093009926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093009927 active site 741093009928 phosphorylation site [posttranslational modification] 741093009929 intermolecular recognition site; other site 741093009930 dimerization interface [polypeptide binding]; other site 741093009931 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741093009932 putative binding surface; other site 741093009933 active site 741093009934 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 741093009935 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 741093009936 active site 741093009937 tetramer interface [polypeptide binding]; other site 741093009938 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 741093009939 metal binding site [ion binding]; metal-binding site 741093009940 substrate binding pocket [chemical binding]; other site 741093009941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009942 D-galactonate transporter; Region: 2A0114; TIGR00893 741093009943 putative substrate translocation pore; other site 741093009944 flavodoxin; Provisional; Region: PRK08105 741093009945 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 741093009946 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 741093009947 probable active site [active] 741093009948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 741093009949 SecY interacting protein Syd; Provisional; Region: PRK04968 741093009950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 741093009951 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 741093009952 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 741093009953 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 741093009954 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 741093009955 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 741093009956 serine transporter; Region: stp; TIGR00814 741093009957 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 741093009958 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 741093009959 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 741093009960 flap endonuclease-like protein; Provisional; Region: PRK09482 741093009961 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 741093009962 active site 741093009963 metal binding site 1 [ion binding]; metal-binding site 741093009964 putative 5' ssDNA interaction site; other site 741093009965 metal binding site 3; metal-binding site 741093009966 metal binding site 2 [ion binding]; metal-binding site 741093009967 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 741093009968 putative DNA binding site [nucleotide binding]; other site 741093009969 putative metal binding site [ion binding]; other site 741093009970 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 741093009971 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 741093009972 dimer interface [polypeptide binding]; other site 741093009973 active site 741093009974 metal binding site [ion binding]; metal-binding site 741093009975 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 741093009976 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 741093009977 intersubunit interface [polypeptide binding]; other site 741093009978 active site 741093009979 Zn2+ binding site [ion binding]; other site 741093009980 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 741093009981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093009982 putative substrate translocation pore; other site 741093009983 L-fucose isomerase; Provisional; Region: fucI; PRK10991 741093009984 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 741093009985 hexamer (dimer of trimers) interface [polypeptide binding]; other site 741093009986 trimer interface [polypeptide binding]; other site 741093009987 substrate binding site [chemical binding]; other site 741093009988 Mn binding site [ion binding]; other site 741093009989 L-fuculokinase; Provisional; Region: PRK10331 741093009990 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 741093009991 putative N- and C-terminal domain interface [polypeptide binding]; other site 741093009992 putative active site [active] 741093009993 putative MgATP binding site [chemical binding]; other site 741093009994 putative catalytic site [active] 741093009995 metal binding site [ion binding]; metal-binding site 741093009996 putative carbohydrate binding site [chemical binding]; other site 741093009997 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 741093009998 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 741093009999 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741093010000 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093010001 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 741093010002 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 741093010003 hypothetical protein; Provisional; Region: PRK10873 741093010004 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741093010005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093010006 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 741093010007 dimerization interface [polypeptide binding]; other site 741093010008 substrate binding pocket [chemical binding]; other site 741093010009 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741093010010 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 741093010011 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 741093010012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741093010013 catalytic residue [active] 741093010014 CsdA-binding activator; Provisional; Region: PRK15019 741093010015 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 741093010016 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 741093010017 putative ATP binding site [chemical binding]; other site 741093010018 putative substrate interface [chemical binding]; other site 741093010019 murein transglycosylase A; Provisional; Region: mltA; PRK11162 741093010020 MltA specific insert domain; Region: MltA; pfam03562 741093010021 3D domain; Region: 3D; pfam06725 741093010022 AMIN domain; Region: AMIN; pfam11741 741093010023 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741093010024 active site 741093010025 metal binding site [ion binding]; metal-binding site 741093010026 N-acetylglutamate synthase; Validated; Region: PRK05279 741093010027 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 741093010028 putative feedback inhibition sensing region; other site 741093010029 putative nucleotide binding site [chemical binding]; other site 741093010030 putative substrate binding site [chemical binding]; other site 741093010031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093010032 Coenzyme A binding pocket [chemical binding]; other site 741093010033 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 741093010034 AAA domain; Region: AAA_30; pfam13604 741093010035 Family description; Region: UvrD_C_2; pfam13538 741093010036 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 741093010037 protease3; Provisional; Region: PRK15101 741093010038 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 741093010039 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741093010040 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741093010041 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 741093010042 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 741093010043 hypothetical protein; Provisional; Region: PRK10332 741093010044 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 741093010045 hypothetical protein; Provisional; Region: PRK11521 741093010046 hypothetical protein; Provisional; Region: PRK10557 741093010047 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 741093010048 hypothetical protein; Provisional; Region: PRK10506 741093010049 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 741093010050 thymidylate synthase; Reviewed; Region: thyA; PRK01827 741093010051 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 741093010052 dimerization interface [polypeptide binding]; other site 741093010053 active site 741093010054 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 741093010055 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 741093010056 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741093010057 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741093010058 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741093010059 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741093010060 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 741093010061 putative active site [active] 741093010062 Ap4A binding site [chemical binding]; other site 741093010063 nudix motif; other site 741093010064 putative metal binding site [ion binding]; other site 741093010065 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 741093010066 putative DNA-binding cleft [nucleotide binding]; other site 741093010067 putative DNA clevage site; other site 741093010068 molecular lever; other site 741093010069 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 741093010070 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741093010071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093010072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093010073 active site 741093010074 catalytic tetrad [active] 741093010075 lysophospholipid transporter LplT; Provisional; Region: PRK11195 741093010076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010077 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 741093010078 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 741093010079 putative acyl-acceptor binding pocket; other site 741093010080 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 741093010081 acyl-activating enzyme (AAE) consensus motif; other site 741093010082 putative AMP binding site [chemical binding]; other site 741093010083 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 741093010084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093010085 DNA binding site [nucleotide binding] 741093010086 domain linker motif; other site 741093010087 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 741093010088 dimerization interface (closed form) [polypeptide binding]; other site 741093010089 ligand binding site [chemical binding]; other site 741093010090 diaminopimelate decarboxylase; Provisional; Region: PRK11165 741093010091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 741093010092 active site 741093010093 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741093010094 substrate binding site [chemical binding]; other site 741093010095 catalytic residues [active] 741093010096 dimer interface [polypeptide binding]; other site 741093010097 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 741093010098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093010099 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 741093010100 putative dimerization interface [polypeptide binding]; other site 741093010101 putative racemase; Provisional; Region: PRK10200 741093010102 aspartate racemase; Region: asp_race; TIGR00035 741093010103 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 741093010104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010105 putative substrate translocation pore; other site 741093010106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010107 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 741093010108 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 741093010109 NADP binding site [chemical binding]; other site 741093010110 homodimer interface [polypeptide binding]; other site 741093010111 active site 741093010112 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 741093010113 putative acyltransferase; Provisional; Region: PRK05790 741093010114 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 741093010115 dimer interface [polypeptide binding]; other site 741093010116 active site 741093010117 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 741093010118 serine transporter; Region: stp; TIGR00814 741093010119 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 741093010120 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 741093010121 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 741093010122 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 741093010123 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 741093010124 Tetratricopeptide repeat; Region: TPR_3; pfam07720 741093010125 Tetratricopeptide repeat; Region: TPR_3; pfam07720 741093010126 transcriptional regulator; Provisional; Region: PRK11906 741093010127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093010128 DNA binding site [nucleotide binding] 741093010129 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 741093010130 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093010131 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093010132 catalytic residue [active] 741093010133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741093010134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093010135 DNA binding residues [nucleotide binding] 741093010136 dimerization interface [polypeptide binding]; other site 741093010137 invasion protein OrgB; Provisional; Region: PRK15322 741093010138 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; pfam09482 741093010139 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 741093010140 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 741093010141 Type III secretion needle MxiH like; Region: MxiH; cl09641 741093010142 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 741093010143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093010144 DNA binding residues [nucleotide binding] 741093010145 dimerization interface [polypeptide binding]; other site 741093010146 type III secretion system protein SpaS; Validated; Region: PRK08156 741093010147 type III secretion system protein SpaQ; Provisional; Region: PRK15333 741093010148 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 741093010149 type III secretion system protein SpaO; Validated; Region: PRK08158 741093010150 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 741093010151 Surface presentation of antigens protein; Region: SPAN; pfam02510 741093010152 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 741093010153 ATP synthase SpaL; Validated; Region: PRK08149 741093010154 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 741093010155 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 741093010156 Walker A motif; other site 741093010157 ATP binding site [chemical binding]; other site 741093010158 Walker B motif; other site 741093010159 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 741093010160 type III secretion system protein InvA; Provisional; Region: PRK15337 741093010161 type III secretion system regulator InvE; Provisional; Region: PRK15338 741093010162 HrpJ-like domain; Region: HrpJ; pfam07201 741093010163 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 741093010164 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741093010165 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741093010166 transcriptional regulator InvF; Provisional; Region: PRK15340 741093010167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093010168 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 741093010169 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 741093010170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741093010171 Peptidase family M23; Region: Peptidase_M23; pfam01551 741093010172 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 741093010173 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 741093010174 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 741093010175 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 741093010176 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 741093010177 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 741093010178 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741093010179 catalytic loop [active] 741093010180 iron binding site [ion binding]; other site 741093010181 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 741093010182 GAF domain; Region: GAF; cl17456 741093010183 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 741093010184 PAS domain; Region: PAS; smart00091 741093010185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093010186 Walker A motif; other site 741093010187 ATP binding site [chemical binding]; other site 741093010188 Walker B motif; other site 741093010189 arginine finger; other site 741093010190 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741093010191 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 741093010192 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 741093010193 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 741093010194 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 741093010195 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 741093010196 catalytic residue [active] 741093010197 peptidase; Reviewed; Region: PRK13004 741093010198 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 741093010199 putative metal binding site [ion binding]; other site 741093010200 putative dimer interface [polypeptide binding]; other site 741093010201 D-hydantoinase; Region: D-hydantoinase; TIGR02033 741093010202 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 741093010203 tetramer interface [polypeptide binding]; other site 741093010204 active site 741093010205 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 741093010206 carbamate kinase; Reviewed; Region: PRK12686 741093010207 putative substrate binding site [chemical binding]; other site 741093010208 homodimer interface [polypeptide binding]; other site 741093010209 nucleotide binding site [chemical binding]; other site 741093010210 nucleotide binding site [chemical binding]; other site 741093010211 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 741093010212 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 741093010213 XdhC Rossmann domain; Region: XdhC_C; pfam13478 741093010214 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 741093010215 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 741093010216 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 741093010217 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 741093010218 Ligand binding site; other site 741093010219 metal-binding site 741093010220 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 741093010221 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741093010222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093010223 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 741093010224 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 741093010225 active site 741093010226 putative substrate binding pocket [chemical binding]; other site 741093010227 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 741093010228 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 741093010229 putative hypoxanthine oxidase; Provisional; Region: PRK09800 741093010230 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 741093010231 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 741093010232 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 741093010233 uracil-xanthine permease; Region: ncs2; TIGR00801 741093010234 guanine deaminase; Provisional; Region: PRK09228 741093010235 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 741093010236 active site 741093010237 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741093010238 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 741093010239 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 741093010240 4Fe-4S binding domain; Region: Fer4; pfam00037 741093010241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741093010242 xanthine permease; Region: pbuX; TIGR03173 741093010243 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 741093010244 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 741093010245 active site 741093010246 metal binding site [ion binding]; metal-binding site 741093010247 nudix motif; other site 741093010248 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 741093010249 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 741093010250 dimer interface [polypeptide binding]; other site 741093010251 putative anticodon binding site; other site 741093010252 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 741093010253 motif 1; other site 741093010254 active site 741093010255 motif 2; other site 741093010256 motif 3; other site 741093010257 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 741093010258 DHH family; Region: DHH; pfam01368 741093010259 DHHA1 domain; Region: DHHA1; pfam02272 741093010260 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 741093010261 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 741093010262 dimerization domain [polypeptide binding]; other site 741093010263 dimer interface [polypeptide binding]; other site 741093010264 catalytic residues [active] 741093010265 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 741093010266 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 741093010267 active site 741093010268 Int/Topo IB signature motif; other site 741093010269 flavodoxin FldB; Provisional; Region: PRK12359 741093010270 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 741093010271 hypothetical protein; Provisional; Region: PRK10878 741093010272 putative global regulator; Reviewed; Region: PRK09559 741093010273 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 741093010274 hemolysin; Provisional; Region: PRK15087 741093010275 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 741093010276 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 741093010277 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 741093010278 beta-galactosidase; Region: BGL; TIGR03356 741093010279 glycine dehydrogenase; Provisional; Region: PRK05367 741093010280 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 741093010281 tetramer interface [polypeptide binding]; other site 741093010282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093010283 catalytic residue [active] 741093010284 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 741093010285 tetramer interface [polypeptide binding]; other site 741093010286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093010287 catalytic residue [active] 741093010288 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 741093010289 lipoyl attachment site [posttranslational modification]; other site 741093010290 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 741093010291 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 741093010292 oxidoreductase; Provisional; Region: PRK08013 741093010293 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 741093010294 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 741093010295 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 741093010296 proline aminopeptidase P II; Provisional; Region: PRK10879 741093010297 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 741093010298 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 741093010299 active site 741093010300 hypothetical protein; Reviewed; Region: PRK01736 741093010301 Z-ring-associated protein; Provisional; Region: PRK10972 741093010302 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 741093010303 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 741093010304 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 741093010305 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 741093010306 ligand binding site [chemical binding]; other site 741093010307 NAD binding site [chemical binding]; other site 741093010308 tetramer interface [polypeptide binding]; other site 741093010309 catalytic site [active] 741093010310 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 741093010311 L-serine binding site [chemical binding]; other site 741093010312 ACT domain interface; other site 741093010313 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 741093010314 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093010315 active site 741093010316 dimer interface [polypeptide binding]; other site 741093010317 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 741093010318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093010319 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 741093010320 putative dimerization interface [polypeptide binding]; other site 741093010321 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 741093010322 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 741093010323 active site 741093010324 substrate binding site [chemical binding]; other site 741093010325 coenzyme B12 binding site [chemical binding]; other site 741093010326 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 741093010327 B12 binding site [chemical binding]; other site 741093010328 cobalt ligand [ion binding]; other site 741093010329 membrane ATPase/protein kinase; Provisional; Region: PRK09435 741093010330 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 741093010331 Walker A; other site 741093010332 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 741093010333 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741093010334 substrate binding site [chemical binding]; other site 741093010335 oxyanion hole (OAH) forming residues; other site 741093010336 trimer interface [polypeptide binding]; other site 741093010337 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 741093010338 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 741093010339 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 741093010340 Uncharacterized conserved protein [Function unknown]; Region: COG2968 741093010341 oxidative stress defense protein; Provisional; Region: PRK11087 741093010342 arginine exporter protein; Provisional; Region: PRK09304 741093010343 mechanosensitive channel MscS; Provisional; Region: PRK10334 741093010344 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741093010345 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 741093010346 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 741093010347 active site 741093010348 intersubunit interface [polypeptide binding]; other site 741093010349 zinc binding site [ion binding]; other site 741093010350 Na+ binding site [ion binding]; other site 741093010351 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 741093010352 Phosphoglycerate kinase; Region: PGK; pfam00162 741093010353 substrate binding site [chemical binding]; other site 741093010354 hinge regions; other site 741093010355 ADP binding site [chemical binding]; other site 741093010356 catalytic site [active] 741093010357 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 741093010358 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 741093010359 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 741093010360 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 741093010361 trimer interface [polypeptide binding]; other site 741093010362 putative Zn binding site [ion binding]; other site 741093010363 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 741093010364 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 741093010365 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 741093010366 Walker A/P-loop; other site 741093010367 ATP binding site [chemical binding]; other site 741093010368 Q-loop/lid; other site 741093010369 ABC transporter signature motif; other site 741093010370 Walker B; other site 741093010371 D-loop; other site 741093010372 H-loop/switch region; other site 741093010373 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 741093010374 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 741093010375 Walker A/P-loop; other site 741093010376 ATP binding site [chemical binding]; other site 741093010377 Q-loop/lid; other site 741093010378 ABC transporter signature motif; other site 741093010379 Walker B; other site 741093010380 D-loop; other site 741093010381 H-loop/switch region; other site 741093010382 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 741093010383 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 741093010384 active site 741093010385 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 741093010386 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 741093010387 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 741093010388 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 741093010389 putative active site [active] 741093010390 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 741093010391 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093010392 putative NAD(P) binding site [chemical binding]; other site 741093010393 catalytic Zn binding site [ion binding]; other site 741093010394 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 741093010395 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 741093010396 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 741093010397 active site 741093010398 P-loop; other site 741093010399 phosphorylation site [posttranslational modification] 741093010400 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093010401 active site 741093010402 phosphorylation site [posttranslational modification] 741093010403 transketolase; Reviewed; Region: PRK12753 741093010404 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 741093010405 TPP-binding site [chemical binding]; other site 741093010406 dimer interface [polypeptide binding]; other site 741093010407 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741093010408 PYR/PP interface [polypeptide binding]; other site 741093010409 dimer interface [polypeptide binding]; other site 741093010410 TPP binding site [chemical binding]; other site 741093010411 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741093010412 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 741093010413 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 741093010414 agmatinase; Region: agmatinase; TIGR01230 741093010415 oligomer interface [polypeptide binding]; other site 741093010416 putative active site [active] 741093010417 Mn binding site [ion binding]; other site 741093010418 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 741093010419 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 741093010420 dimer interface [polypeptide binding]; other site 741093010421 active site 741093010422 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741093010423 catalytic residues [active] 741093010424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 741093010425 Virulence promoting factor; Region: YqgB; pfam11036 741093010426 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 741093010427 S-adenosylmethionine synthetase; Validated; Region: PRK05250 741093010428 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 741093010429 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 741093010430 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 741093010431 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 741093010432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010433 putative substrate translocation pore; other site 741093010434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010435 hypothetical protein; Provisional; Region: PRK04860 741093010436 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 741093010437 DNA-specific endonuclease I; Provisional; Region: PRK15137 741093010438 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 741093010439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 741093010440 RNA methyltransferase, RsmE family; Region: TIGR00046 741093010441 glutathione synthetase; Provisional; Region: PRK05246 741093010442 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 741093010443 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 741093010444 hypothetical protein; Validated; Region: PRK00228 741093010445 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 741093010446 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 741093010447 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 741093010448 Walker A motif; other site 741093010449 ATP binding site [chemical binding]; other site 741093010450 Walker B motif; other site 741093010451 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 741093010452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741093010453 catalytic residue [active] 741093010454 YGGT family; Region: YGGT; pfam02325 741093010455 YGGT family; Region: YGGT; pfam02325 741093010456 hypothetical protein; Validated; Region: PRK05090 741093010457 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 741093010458 active site 741093010459 dimerization interface [polypeptide binding]; other site 741093010460 HemN family oxidoreductase; Provisional; Region: PRK05660 741093010461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093010462 FeS/SAM binding site; other site 741093010463 HemN C-terminal domain; Region: HemN_C; pfam06969 741093010464 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 741093010465 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 741093010466 homodimer interface [polypeptide binding]; other site 741093010467 active site 741093010468 hypothetical protein; Provisional; Region: PRK10626 741093010469 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 741093010470 hypothetical protein; Provisional; Region: PRK11702 741093010471 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 741093010472 adenine DNA glycosylase; Provisional; Region: PRK10880 741093010473 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 741093010474 minor groove reading motif; other site 741093010475 helix-hairpin-helix signature motif; other site 741093010476 substrate binding pocket [chemical binding]; other site 741093010477 active site 741093010478 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 741093010479 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 741093010480 DNA binding and oxoG recognition site [nucleotide binding] 741093010481 oxidative damage protection protein; Provisional; Region: PRK05408 741093010482 murein transglycosylase C; Provisional; Region: mltC; PRK11671 741093010483 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 741093010484 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093010485 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093010486 catalytic residue [active] 741093010487 nucleoside transporter; Region: 2A0110; TIGR00889 741093010488 ornithine decarboxylase; Provisional; Region: PRK13578 741093010489 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741093010490 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741093010491 homodimer interface [polypeptide binding]; other site 741093010492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093010493 catalytic residue [active] 741093010494 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741093010495 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 741093010496 integrase; Provisional; Region: PRK09692 741093010497 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093010498 active site 741093010499 Int/Topo IB signature motif; other site 741093010500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 741093010501 Homeodomain-like domain; Region: HTH_23; pfam13384 741093010502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093010503 Transposase; Region: HTH_Tnp_1; pfam01527 741093010504 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093010505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093010506 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093010507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093010508 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093010509 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093010510 Nuclease-related domain; Region: NERD; pfam08378 741093010511 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 741093010512 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 741093010513 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 741093010514 type III secretion system protein; Provisional; Region: PRK15384; cl14665 741093010515 Winged helix-turn helix; Region: HTH_29; pfam13551 741093010516 Homeodomain-like domain; Region: HTH_23; pfam13384 741093010517 Homeodomain-like domain; Region: HTH_32; pfam13565 741093010518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 741093010519 DDE superfamily endonuclease; Region: DDE_3; pfam13358 741093010520 putative transposase OrfB; Reviewed; Region: PHA02517 741093010521 HTH-like domain; Region: HTH_21; pfam13276 741093010522 Integrase core domain; Region: rve; pfam00665 741093010523 Integrase core domain; Region: rve_3; pfam13683 741093010524 Transposase; Region: HTH_Tnp_1; cl17663 741093010525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093010526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093010527 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093010528 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093010529 homodimer interface [polypeptide binding]; other site 741093010530 putative GKAP docking site [polypeptide binding]; other site 741093010531 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093010532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093010533 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093010534 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093010535 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093010536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093010537 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093010538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093010539 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093010540 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093010541 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093010542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093010543 Transposase; Region: HTH_Tnp_1; cl17663 741093010544 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 741093010545 Phosphate transporter family; Region: PHO4; cl00396 741093010546 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 741093010547 CHAP domain; Region: CHAP; pfam05257 741093010548 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 741093010549 putative S-transferase; Provisional; Region: PRK11752 741093010550 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 741093010551 C-terminal domain interface [polypeptide binding]; other site 741093010552 GSH binding site (G-site) [chemical binding]; other site 741093010553 dimer interface [polypeptide binding]; other site 741093010554 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 741093010555 dimer interface [polypeptide binding]; other site 741093010556 N-terminal domain interface [polypeptide binding]; other site 741093010557 active site 741093010558 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 741093010559 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 741093010560 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 741093010561 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 741093010562 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 741093010563 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 741093010564 putative substrate-binding site; other site 741093010565 nickel binding site [ion binding]; other site 741093010566 hydrogenase 2 large subunit; Provisional; Region: PRK10467 741093010567 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 741093010568 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 741093010569 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 741093010570 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 741093010571 4Fe-4S binding domain; Region: Fer4_6; pfam12837 741093010572 hydrogenase 2 small subunit; Provisional; Region: PRK10468 741093010573 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 741093010574 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 741093010575 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 741093010576 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 741093010577 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741093010578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093010579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093010580 active site 741093010581 catalytic tetrad [active] 741093010582 hypothetical protein; Provisional; Region: PRK05208 741093010583 oxidoreductase; Provisional; Region: PRK07985 741093010584 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 741093010585 NAD binding site [chemical binding]; other site 741093010586 metal binding site [ion binding]; metal-binding site 741093010587 active site 741093010588 biopolymer transport protein ExbD; Provisional; Region: PRK11267 741093010589 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 741093010590 biopolymer transport protein ExbB; Provisional; Region: PRK10414 741093010591 cystathionine beta-lyase; Provisional; Region: PRK08114 741093010592 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 741093010593 homodimer interface [polypeptide binding]; other site 741093010594 substrate-cofactor binding pocket; other site 741093010595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093010596 catalytic residue [active] 741093010597 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741093010598 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 741093010599 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 741093010600 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741093010601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093010602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093010603 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 741093010604 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 741093010605 dimer interface [polypeptide binding]; other site 741093010606 active site 741093010607 metal binding site [ion binding]; metal-binding site 741093010608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741093010609 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741093010610 active site 741093010611 catalytic tetrad [active] 741093010612 putative outer membrane lipoprotein; Provisional; Region: PRK09973 741093010613 hypothetical protein; Provisional; Region: PRK01254 741093010614 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 741093010615 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 741093010616 FtsI repressor; Provisional; Region: PRK10883 741093010617 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 741093010618 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 741093010619 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 741093010620 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 741093010621 putative acyl-acceptor binding pocket; other site 741093010622 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 741093010623 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 741093010624 CAP-like domain; other site 741093010625 active site 741093010626 primary dimer interface [polypeptide binding]; other site 741093010627 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741093010628 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 741093010629 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 741093010630 peptide binding site [polypeptide binding]; other site 741093010631 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 741093010632 TIGR00156 family protein; Region: TIGR00156 741093010633 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 741093010634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093010635 active site 741093010636 phosphorylation site [posttranslational modification] 741093010637 intermolecular recognition site; other site 741093010638 dimerization interface [polypeptide binding]; other site 741093010639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093010640 DNA binding site [nucleotide binding] 741093010641 sensor protein QseC; Provisional; Region: PRK10337 741093010642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093010643 dimer interface [polypeptide binding]; other site 741093010644 phosphorylation site [posttranslational modification] 741093010645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093010646 ATP binding site [chemical binding]; other site 741093010647 Mg2+ binding site [ion binding]; other site 741093010648 G-X-G motif; other site 741093010649 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 741093010650 Uncharacterized conserved protein [Function unknown]; Region: COG1359 741093010651 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741093010652 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741093010653 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 741093010654 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 741093010655 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 741093010656 siderophore binding site; other site 741093010657 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 741093010658 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093010659 ABC-ATPase subunit interface; other site 741093010660 dimer interface [polypeptide binding]; other site 741093010661 putative PBP binding regions; other site 741093010662 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741093010663 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093010664 dimer interface [polypeptide binding]; other site 741093010665 putative PBP binding regions; other site 741093010666 ABC-ATPase subunit interface; other site 741093010667 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 741093010668 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741093010669 Walker A/P-loop; other site 741093010670 ATP binding site [chemical binding]; other site 741093010671 Q-loop/lid; other site 741093010672 ABC transporter signature motif; other site 741093010673 Walker B; other site 741093010674 D-loop; other site 741093010675 H-loop/switch region; other site 741093010676 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 741093010677 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093010678 N-terminal plug; other site 741093010679 ligand-binding site [chemical binding]; other site 741093010680 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 741093010681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093010682 ATP binding site [chemical binding]; other site 741093010683 Mg2+ binding site [ion binding]; other site 741093010684 G-X-G motif; other site 741093010685 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 741093010686 anchoring element; other site 741093010687 dimer interface [polypeptide binding]; other site 741093010688 ATP binding site [chemical binding]; other site 741093010689 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 741093010690 active site 741093010691 metal binding site [ion binding]; metal-binding site 741093010692 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 741093010693 esterase YqiA; Provisional; Region: PRK11071 741093010694 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741093010695 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 741093010696 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741093010697 active site 741093010698 metal binding site [ion binding]; metal-binding site 741093010699 hexamer interface [polypeptide binding]; other site 741093010700 putative dehydrogenase; Provisional; Region: PRK11039 741093010701 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 741093010702 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 741093010703 dimer interface [polypeptide binding]; other site 741093010704 ADP-ribose binding site [chemical binding]; other site 741093010705 active site 741093010706 nudix motif; other site 741093010707 metal binding site [ion binding]; metal-binding site 741093010708 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 741093010709 hypothetical protein; Provisional; Region: PRK11653 741093010710 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 741093010711 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 741093010712 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 741093010713 putative active site [active] 741093010714 metal binding site [ion binding]; metal-binding site 741093010715 zinc transporter ZupT; Provisional; Region: PRK04201 741093010716 ZIP Zinc transporter; Region: Zip; pfam02535 741093010717 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 741093010718 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 741093010719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 741093010720 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 741093010721 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 741093010722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 741093010723 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 741093010724 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 741093010725 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 741093010726 putative ribose interaction site [chemical binding]; other site 741093010727 putative ADP binding site [chemical binding]; other site 741093010728 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 741093010729 active site 741093010730 nucleotide binding site [chemical binding]; other site 741093010731 HIGH motif; other site 741093010732 KMSKS motif; other site 741093010733 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 741093010734 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 741093010735 metal binding triad; other site 741093010736 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 741093010737 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 741093010738 metal binding triad; other site 741093010739 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 741093010740 Uncharacterized conserved protein [Function unknown]; Region: COG3025 741093010741 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 741093010742 putative active site [active] 741093010743 putative metal binding residues [ion binding]; other site 741093010744 signature motif; other site 741093010745 putative triphosphate binding site [ion binding]; other site 741093010746 CHAD domain; Region: CHAD; pfam05235 741093010747 SH3 domain-containing protein; Provisional; Region: PRK10884 741093010748 Bacterial SH3 domain homologues; Region: SH3b; smart00287 741093010749 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 741093010750 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 741093010751 active site 741093010752 NTP binding site [chemical binding]; other site 741093010753 metal binding triad [ion binding]; metal-binding site 741093010754 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 741093010755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741093010756 Zn2+ binding site [ion binding]; other site 741093010757 Mg2+ binding site [ion binding]; other site 741093010758 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 741093010759 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 741093010760 homooctamer interface [polypeptide binding]; other site 741093010761 active site 741093010762 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 741093010763 transcriptional activator TtdR; Provisional; Region: PRK09801 741093010764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093010765 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 741093010766 putative effector binding pocket; other site 741093010767 putative dimerization interface [polypeptide binding]; other site 741093010768 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 741093010769 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 741093010770 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741093010771 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 741093010772 transmembrane helices; other site 741093010773 UGMP family protein; Validated; Region: PRK09604 741093010774 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 741093010775 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 741093010776 DNA primase; Validated; Region: dnaG; PRK05667 741093010777 CHC2 zinc finger; Region: zf-CHC2; pfam01807 741093010778 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 741093010779 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 741093010780 active site 741093010781 metal binding site [ion binding]; metal-binding site 741093010782 interdomain interaction site; other site 741093010783 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 741093010784 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 741093010785 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 741093010786 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 741093010787 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 741093010788 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 741093010789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741093010790 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 741093010791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741093010792 DNA binding residues [nucleotide binding] 741093010793 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 741093010794 active site 741093010795 SUMO-1 interface [polypeptide binding]; other site 741093010796 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 741093010797 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 741093010798 FAD binding pocket [chemical binding]; other site 741093010799 FAD binding motif [chemical binding]; other site 741093010800 phosphate binding motif [ion binding]; other site 741093010801 NAD binding pocket [chemical binding]; other site 741093010802 Predicted transcriptional regulators [Transcription]; Region: COG1695 741093010803 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 741093010804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093010805 PAS fold; Region: PAS_3; pfam08447 741093010806 putative active site [active] 741093010807 heme pocket [chemical binding]; other site 741093010808 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 741093010809 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741093010810 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741093010811 dimer interface [polypeptide binding]; other site 741093010812 putative CheW interface [polypeptide binding]; other site 741093010813 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 741093010814 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093010815 inhibitor-cofactor binding pocket; inhibition site 741093010816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093010817 catalytic residue [active] 741093010818 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 741093010819 dimer interface [polypeptide binding]; other site 741093010820 putative tRNA-binding site [nucleotide binding]; other site 741093010821 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 741093010822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093010823 DNA binding site [nucleotide binding] 741093010824 domain linker motif; other site 741093010825 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 741093010826 putative dimerization interface [polypeptide binding]; other site 741093010827 putative ligand binding site [chemical binding]; other site 741093010828 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 741093010829 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 741093010830 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 741093010831 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 741093010832 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 741093010833 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 741093010834 inner membrane transporter YjeM; Provisional; Region: PRK15238 741093010835 alpha-glucosidase; Provisional; Region: PRK10137 741093010836 Protein of unknown function, DUF608; Region: DUF608; pfam04685 741093010837 Trehalase; Region: Trehalase; cl17346 741093010838 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741093010839 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 741093010840 active site 741093010841 FMN binding site [chemical binding]; other site 741093010842 2,4-decadienoyl-CoA binding site; other site 741093010843 catalytic residue [active] 741093010844 4Fe-4S cluster binding site [ion binding]; other site 741093010845 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 741093010846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093010847 non-specific DNA binding site [nucleotide binding]; other site 741093010848 salt bridge; other site 741093010849 sequence-specific DNA binding site [nucleotide binding]; other site 741093010850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 741093010851 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 741093010852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093010853 S-adenosylmethionine binding site [chemical binding]; other site 741093010854 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 741093010855 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 741093010856 putative active site [active] 741093010857 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741093010858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741093010859 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 741093010860 serine/threonine transporter SstT; Provisional; Region: PRK13628 741093010861 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741093010862 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 741093010863 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 741093010864 galactarate dehydratase; Region: galactar-dH20; TIGR03248 741093010865 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 741093010866 Glucuronate isomerase; Region: UxaC; pfam02614 741093010867 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 741093010868 D-galactonate transporter; Region: 2A0114; TIGR00893 741093010869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010870 putative substrate translocation pore; other site 741093010871 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 741093010872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093010873 DNA-binding site [nucleotide binding]; DNA binding site 741093010874 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741093010875 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741093010876 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 741093010877 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 741093010878 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 741093010879 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 741093010880 Predicted membrane protein [Function unknown]; Region: COG5393 741093010881 YqjK-like protein; Region: YqjK; pfam13997 741093010882 Predicted membrane protein [Function unknown]; Region: COG2259 741093010883 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 741093010884 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 741093010885 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 741093010886 putative dimer interface [polypeptide binding]; other site 741093010887 N-terminal domain interface [polypeptide binding]; other site 741093010888 putative substrate binding pocket (H-site) [chemical binding]; other site 741093010889 Predicted membrane protein [Function unknown]; Region: COG3152 741093010890 Predicted membrane protein [Function unknown]; Region: COG3152 741093010891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093010892 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 741093010893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093010894 dimerization interface [polypeptide binding]; other site 741093010895 Pirin-related protein [General function prediction only]; Region: COG1741 741093010896 Pirin; Region: Pirin; pfam02678 741093010897 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 741093010898 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 741093010899 serine transporter; Region: stp; TIGR00814 741093010900 L-serine dehydratase TdcG; Provisional; Region: PRK15040 741093010901 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 741093010902 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 741093010903 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 741093010904 homotrimer interaction site [polypeptide binding]; other site 741093010905 putative active site [active] 741093010906 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 741093010907 Pyruvate formate lyase 1; Region: PFL1; cd01678 741093010908 coenzyme A binding site [chemical binding]; other site 741093010909 active site 741093010910 catalytic residues [active] 741093010911 glycine loop; other site 741093010912 propionate/acetate kinase; Provisional; Region: PRK12379 741093010913 Acetokinase family; Region: Acetate_kinase; cl17229 741093010914 threonine/serine transporter TdcC; Provisional; Region: PRK13629 741093010915 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 741093010916 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 741093010917 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 741093010918 tetramer interface [polypeptide binding]; other site 741093010919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093010920 catalytic residue [active] 741093010921 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 741093010922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093010923 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 741093010924 putative substrate binding pocket [chemical binding]; other site 741093010925 putative dimerization interface [polypeptide binding]; other site 741093010926 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 741093010927 hypothetical protein; Provisional; Region: PRK09716 741093010928 glycerate kinase I; Provisional; Region: PRK10342 741093010929 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 741093010930 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741093010931 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 741093010932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093010933 D-galactonate transporter; Region: 2A0114; TIGR00893 741093010934 putative substrate translocation pore; other site 741093010935 galactarate dehydratase; Region: galactar-dH20; TIGR03248 741093010936 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 741093010937 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 741093010938 putative regulator PrlF; Provisional; Region: PRK09974 741093010939 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 741093010940 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 741093010941 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 741093010942 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741093010943 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093010944 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 741093010945 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 741093010946 active site 741093010947 phosphorylation site [posttranslational modification] 741093010948 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 741093010949 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 741093010950 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 741093010951 active pocket/dimerization site; other site 741093010952 active site 741093010953 phosphorylation site [posttranslational modification] 741093010954 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 741093010955 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 741093010956 active site 741093010957 dimer interface [polypeptide binding]; other site 741093010958 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 741093010959 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 741093010960 dimer interface [polypeptide binding]; other site 741093010961 active site 741093010962 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 741093010963 putative active site [active] 741093010964 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 741093010965 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 741093010966 active site 741093010967 intersubunit interface [polypeptide binding]; other site 741093010968 zinc binding site [ion binding]; other site 741093010969 Na+ binding site [ion binding]; other site 741093010970 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 741093010971 active site 741093010972 phosphorylation site [posttranslational modification] 741093010973 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 741093010974 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093010975 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741093010976 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093010977 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093010978 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741093010979 PapC N-terminal domain; Region: PapC_N; pfam13954 741093010980 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093010981 PapC C-terminal domain; Region: PapC_C; pfam13953 741093010982 Transposase; Region: HTH_Tnp_1; cl17663 741093010983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093010984 putative transposase OrfB; Reviewed; Region: PHA02517 741093010985 HTH-like domain; Region: HTH_21; pfam13276 741093010986 Integrase core domain; Region: rve; pfam00665 741093010987 Integrase core domain; Region: rve_3; pfam13683 741093010988 Fimbrial protein; Region: Fimbrial; pfam00419 741093010989 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 741093010990 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 741093010991 putative SAM binding site [chemical binding]; other site 741093010992 putative homodimer interface [polypeptide binding]; other site 741093010993 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 741093010994 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 741093010995 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 741093010996 putative ligand binding site [chemical binding]; other site 741093010997 TIGR00252 family protein; Region: TIGR00252 741093010998 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 741093010999 dimer interface [polypeptide binding]; other site 741093011000 active site 741093011001 outer membrane lipoprotein; Provisional; Region: PRK11023 741093011002 BON domain; Region: BON; pfam04972 741093011003 BON domain; Region: BON; pfam04972 741093011004 Predicted permease; Region: DUF318; pfam03773 741093011005 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 741093011006 NADH(P)-binding; Region: NAD_binding_10; pfam13460 741093011007 NAD binding site [chemical binding]; other site 741093011008 active site 741093011009 intracellular protease, PfpI family; Region: PfpI; TIGR01382 741093011010 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 741093011011 proposed catalytic triad [active] 741093011012 conserved cys residue [active] 741093011013 hypothetical protein; Provisional; Region: PRK03467 741093011014 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 741093011015 GIY-YIG motif/motif A; other site 741093011016 putative active site [active] 741093011017 putative metal binding site [ion binding]; other site 741093011018 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 741093011019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093011020 Coenzyme A binding pocket [chemical binding]; other site 741093011021 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 741093011022 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 741093011023 Peptidase family U32; Region: Peptidase_U32; pfam01136 741093011024 putative protease; Provisional; Region: PRK15447 741093011025 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 741093011026 hypothetical protein; Provisional; Region: PRK10508 741093011027 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 741093011028 tryptophan permease; Provisional; Region: PRK10483 741093011029 aromatic amino acid transport protein; Region: araaP; TIGR00837 741093011030 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 741093011031 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741093011032 ATP binding site [chemical binding]; other site 741093011033 Mg++ binding site [ion binding]; other site 741093011034 motif III; other site 741093011035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093011036 nucleotide binding region [chemical binding]; other site 741093011037 ATP-binding site [chemical binding]; other site 741093011038 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 741093011039 putative RNA binding site [nucleotide binding]; other site 741093011040 lipoprotein NlpI; Provisional; Region: PRK11189 741093011041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093011042 binding surface 741093011043 TPR motif; other site 741093011044 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 741093011045 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 741093011046 RNase E interface [polypeptide binding]; other site 741093011047 trimer interface [polypeptide binding]; other site 741093011048 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 741093011049 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 741093011050 RNase E interface [polypeptide binding]; other site 741093011051 trimer interface [polypeptide binding]; other site 741093011052 active site 741093011053 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 741093011054 putative nucleic acid binding region [nucleotide binding]; other site 741093011055 G-X-X-G motif; other site 741093011056 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 741093011057 RNA binding site [nucleotide binding]; other site 741093011058 domain interface; other site 741093011059 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 741093011060 16S/18S rRNA binding site [nucleotide binding]; other site 741093011061 S13e-L30e interaction site [polypeptide binding]; other site 741093011062 25S rRNA binding site [nucleotide binding]; other site 741093011063 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 741093011064 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 741093011065 RNA binding site [nucleotide binding]; other site 741093011066 active site 741093011067 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 741093011068 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 741093011069 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 741093011070 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 741093011071 translation initiation factor IF-2; Region: IF-2; TIGR00487 741093011072 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 741093011073 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 741093011074 G1 box; other site 741093011075 putative GEF interaction site [polypeptide binding]; other site 741093011076 GTP/Mg2+ binding site [chemical binding]; other site 741093011077 Switch I region; other site 741093011078 G2 box; other site 741093011079 G3 box; other site 741093011080 Switch II region; other site 741093011081 G4 box; other site 741093011082 G5 box; other site 741093011083 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 741093011084 Translation-initiation factor 2; Region: IF-2; pfam11987 741093011085 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 741093011086 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 741093011087 NusA N-terminal domain; Region: NusA_N; pfam08529 741093011088 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 741093011089 RNA binding site [nucleotide binding]; other site 741093011090 homodimer interface [polypeptide binding]; other site 741093011091 NusA-like KH domain; Region: KH_5; pfam13184 741093011092 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 741093011093 G-X-X-G motif; other site 741093011094 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 741093011095 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 741093011096 ribosome maturation protein RimP; Reviewed; Region: PRK00092 741093011097 Sm and related proteins; Region: Sm_like; cl00259 741093011098 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 741093011099 putative oligomer interface [polypeptide binding]; other site 741093011100 putative RNA binding site [nucleotide binding]; other site 741093011101 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 741093011102 ANP binding site [chemical binding]; other site 741093011103 Substrate Binding Site II [chemical binding]; other site 741093011104 Substrate Binding Site I [chemical binding]; other site 741093011105 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 741093011106 Sulfatase; Region: Sulfatase; pfam00884 741093011107 Preprotein translocase SecG subunit; Region: SecG; pfam03840 741093011108 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 741093011109 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 741093011110 active site 741093011111 substrate binding site [chemical binding]; other site 741093011112 metal binding site [ion binding]; metal-binding site 741093011113 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 741093011114 dihydropteroate synthase; Region: DHPS; TIGR01496 741093011115 substrate binding pocket [chemical binding]; other site 741093011116 dimer interface [polypeptide binding]; other site 741093011117 inhibitor binding site; inhibition site 741093011118 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 741093011119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093011120 Walker A motif; other site 741093011121 ATP binding site [chemical binding]; other site 741093011122 Walker B motif; other site 741093011123 arginine finger; other site 741093011124 Peptidase family M41; Region: Peptidase_M41; pfam01434 741093011125 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 741093011126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093011127 S-adenosylmethionine binding site [chemical binding]; other site 741093011128 RNA-binding protein YhbY; Provisional; Region: PRK10343 741093011129 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 741093011130 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 741093011131 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 741093011132 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 741093011133 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 741093011134 GTPase CgtA; Reviewed; Region: obgE; PRK12298 741093011135 GTP1/OBG; Region: GTP1_OBG; pfam01018 741093011136 Obg GTPase; Region: Obg; cd01898 741093011137 G1 box; other site 741093011138 GTP/Mg2+ binding site [chemical binding]; other site 741093011139 Switch I region; other site 741093011140 G2 box; other site 741093011141 G3 box; other site 741093011142 Switch II region; other site 741093011143 G4 box; other site 741093011144 G5 box; other site 741093011145 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 741093011146 EamA-like transporter family; Region: EamA; pfam00892 741093011147 EamA-like transporter family; Region: EamA; pfam00892 741093011148 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 741093011149 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 741093011150 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 741093011151 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 741093011152 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 741093011153 substrate binding pocket [chemical binding]; other site 741093011154 chain length determination region; other site 741093011155 substrate-Mg2+ binding site; other site 741093011156 catalytic residues [active] 741093011157 aspartate-rich region 1; other site 741093011158 active site lid residues [active] 741093011159 aspartate-rich region 2; other site 741093011160 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 741093011161 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 741093011162 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 741093011163 hinge; other site 741093011164 active site 741093011165 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 741093011166 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 741093011167 anti sigma factor interaction site; other site 741093011168 regulatory phosphorylation site [posttranslational modification]; other site 741093011169 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 741093011170 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 741093011171 mce related protein; Region: MCE; pfam02470 741093011172 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 741093011173 conserved hypothetical integral membrane protein; Region: TIGR00056 741093011174 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 741093011175 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 741093011176 Walker A/P-loop; other site 741093011177 ATP binding site [chemical binding]; other site 741093011178 Q-loop/lid; other site 741093011179 ABC transporter signature motif; other site 741093011180 Walker B; other site 741093011181 D-loop; other site 741093011182 H-loop/switch region; other site 741093011183 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 741093011184 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 741093011185 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 741093011186 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 741093011187 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 741093011188 putative active site [active] 741093011189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 741093011190 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 741093011191 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 741093011192 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 741093011193 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 741093011194 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 741093011195 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 741093011196 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 741093011197 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 741093011198 Walker A/P-loop; other site 741093011199 ATP binding site [chemical binding]; other site 741093011200 Q-loop/lid; other site 741093011201 ABC transporter signature motif; other site 741093011202 Walker B; other site 741093011203 D-loop; other site 741093011204 H-loop/switch region; other site 741093011205 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 741093011206 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 741093011207 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 741093011208 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 741093011209 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 741093011210 30S subunit binding site; other site 741093011211 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093011212 active site 741093011213 phosphorylation site [posttranslational modification] 741093011214 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 741093011215 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093011216 dimerization domain swap beta strand [polypeptide binding]; other site 741093011217 regulatory protein interface [polypeptide binding]; other site 741093011218 active site 741093011219 regulatory phosphorylation site [posttranslational modification]; other site 741093011220 hypothetical protein; Provisional; Region: PRK10345 741093011221 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 741093011222 Transglycosylase; Region: Transgly; cl17702 741093011223 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 741093011224 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 741093011225 conserved cys residue [active] 741093011226 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 741093011227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093011228 putative active site [active] 741093011229 heme pocket [chemical binding]; other site 741093011230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093011231 dimer interface [polypeptide binding]; other site 741093011232 phosphorylation site [posttranslational modification] 741093011233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093011234 ATP binding site [chemical binding]; other site 741093011235 Mg2+ binding site [ion binding]; other site 741093011236 G-X-G motif; other site 741093011237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093011238 active site 741093011239 phosphorylation site [posttranslational modification] 741093011240 intermolecular recognition site; other site 741093011241 dimerization interface [polypeptide binding]; other site 741093011242 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741093011243 putative binding surface; other site 741093011244 active site 741093011245 radical SAM protein, TIGR01212 family; Region: TIGR01212 741093011246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093011247 FeS/SAM binding site; other site 741093011248 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 741093011249 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 741093011250 active site 741093011251 dimer interface [polypeptide binding]; other site 741093011252 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 741093011253 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 741093011254 active site 741093011255 FMN binding site [chemical binding]; other site 741093011256 substrate binding site [chemical binding]; other site 741093011257 3Fe-4S cluster binding site [ion binding]; other site 741093011258 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 741093011259 domain interface; other site 741093011260 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 741093011261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093011262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093011263 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 741093011264 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 741093011265 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 741093011266 N-acetylmannosamine kinase; Provisional; Region: PRK05082 741093011267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741093011268 nucleotide binding site [chemical binding]; other site 741093011269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 741093011270 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 741093011271 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 741093011272 putative active site cavity [active] 741093011273 putative sialic acid transporter; Provisional; Region: PRK03893 741093011274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093011275 putative substrate translocation pore; other site 741093011276 N-acetylneuraminate lyase; Region: nanA; TIGR00683 741093011277 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 741093011278 inhibitor site; inhibition site 741093011279 active site 741093011280 dimer interface [polypeptide binding]; other site 741093011281 catalytic residue [active] 741093011282 transcriptional regulator NanR; Provisional; Region: PRK03837 741093011283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093011284 DNA-binding site [nucleotide binding]; DNA binding site 741093011285 FCD domain; Region: FCD; pfam07729 741093011286 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 741093011287 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 741093011288 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 741093011289 stringent starvation protein A; Provisional; Region: sspA; PRK09481 741093011290 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 741093011291 C-terminal domain interface [polypeptide binding]; other site 741093011292 putative GSH binding site (G-site) [chemical binding]; other site 741093011293 dimer interface [polypeptide binding]; other site 741093011294 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 741093011295 dimer interface [polypeptide binding]; other site 741093011296 N-terminal domain interface [polypeptide binding]; other site 741093011297 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 741093011298 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 741093011299 23S rRNA interface [nucleotide binding]; other site 741093011300 L3 interface [polypeptide binding]; other site 741093011301 Predicted ATPase [General function prediction only]; Region: COG1485 741093011302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 741093011303 hypothetical protein; Provisional; Region: PRK11677 741093011304 serine endoprotease; Provisional; Region: PRK10139 741093011305 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 741093011306 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741093011307 protein binding site [polypeptide binding]; other site 741093011308 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741093011309 serine endoprotease; Provisional; Region: PRK10898 741093011310 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 741093011311 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741093011312 malate dehydrogenase; Provisional; Region: PRK05086 741093011313 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 741093011314 NAD binding site [chemical binding]; other site 741093011315 dimerization interface [polypeptide binding]; other site 741093011316 Substrate binding site [chemical binding]; other site 741093011317 arginine repressor; Provisional; Region: PRK05066 741093011318 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 741093011319 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 741093011320 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093011321 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 741093011322 RNAase interaction site [polypeptide binding]; other site 741093011323 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 741093011324 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741093011325 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 741093011326 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093011327 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093011328 efflux system membrane protein; Provisional; Region: PRK11594 741093011329 transcriptional regulator; Provisional; Region: PRK10632 741093011330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093011331 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741093011332 putative effector binding pocket; other site 741093011333 dimerization interface [polypeptide binding]; other site 741093011334 protease TldD; Provisional; Region: tldD; PRK10735 741093011335 hypothetical protein; Provisional; Region: PRK10899 741093011336 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 741093011337 ribonuclease G; Provisional; Region: PRK11712 741093011338 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 741093011339 homodimer interface [polypeptide binding]; other site 741093011340 oligonucleotide binding site [chemical binding]; other site 741093011341 Maf-like protein; Region: Maf; pfam02545 741093011342 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 741093011343 active site 741093011344 dimer interface [polypeptide binding]; other site 741093011345 rod shape-determining protein MreD; Provisional; Region: PRK11060 741093011346 rod shape-determining protein MreC; Region: mreC; TIGR00219 741093011347 rod shape-determining protein MreC; Region: MreC; pfam04085 741093011348 rod shape-determining protein MreB; Provisional; Region: PRK13927 741093011349 MreB and similar proteins; Region: MreB_like; cd10225 741093011350 nucleotide binding site [chemical binding]; other site 741093011351 Mg binding site [ion binding]; other site 741093011352 putative protofilament interaction site [polypeptide binding]; other site 741093011353 RodZ interaction site [polypeptide binding]; other site 741093011354 regulatory protein CsrD; Provisional; Region: PRK11059 741093011355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093011356 metal binding site [ion binding]; metal-binding site 741093011357 active site 741093011358 I-site; other site 741093011359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093011360 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 741093011361 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 741093011362 NADP binding site [chemical binding]; other site 741093011363 dimer interface [polypeptide binding]; other site 741093011364 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 741093011365 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 741093011366 carboxyltransferase (CT) interaction site; other site 741093011367 biotinylation site [posttranslational modification]; other site 741093011368 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 741093011369 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741093011370 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 741093011371 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 741093011372 hypothetical protein; Provisional; Region: PRK10633 741093011373 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 741093011374 Na binding site [ion binding]; other site 741093011375 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 741093011376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 741093011377 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 741093011378 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 741093011379 FMN binding site [chemical binding]; other site 741093011380 active site 741093011381 catalytic residues [active] 741093011382 substrate binding site [chemical binding]; other site 741093011383 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 741093011384 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 741093011385 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741093011386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093011387 DNA methylase; Region: N6_N4_Mtase; pfam01555 741093011388 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 741093011389 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 741093011390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093011391 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 741093011392 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 741093011393 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093011394 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093011395 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 741093011396 Protein export membrane protein; Region: SecD_SecF; cl14618 741093011397 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 741093011398 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 741093011399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093011400 substrate binding pocket [chemical binding]; other site 741093011401 membrane-bound complex binding site; other site 741093011402 hinge residues; other site 741093011403 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 741093011404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093011405 conserved gate region; other site 741093011406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093011407 dimer interface [polypeptide binding]; other site 741093011408 conserved gate region; other site 741093011409 putative PBP binding loops; other site 741093011410 ABC-ATPase subunit interface; other site 741093011411 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741093011412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093011413 dimer interface [polypeptide binding]; other site 741093011414 conserved gate region; other site 741093011415 putative PBP binding loops; other site 741093011416 ABC-ATPase subunit interface; other site 741093011417 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741093011418 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741093011419 Walker A/P-loop; other site 741093011420 ATP binding site [chemical binding]; other site 741093011421 Q-loop/lid; other site 741093011422 ABC transporter signature motif; other site 741093011423 Walker B; other site 741093011424 D-loop; other site 741093011425 H-loop/switch region; other site 741093011426 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 741093011427 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 741093011428 trimer interface [polypeptide binding]; other site 741093011429 putative metal binding site [ion binding]; other site 741093011430 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 741093011431 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 741093011432 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 741093011433 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 741093011434 shikimate binding site; other site 741093011435 NAD(P) binding site [chemical binding]; other site 741093011436 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 741093011437 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741093011438 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 741093011439 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741093011440 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741093011441 hypothetical protein; Validated; Region: PRK03430 741093011442 hypothetical protein; Provisional; Region: PRK10736 741093011443 DNA protecting protein DprA; Region: dprA; TIGR00732 741093011444 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 741093011445 active site 741093011446 catalytic residues [active] 741093011447 metal binding site [ion binding]; metal-binding site 741093011448 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 741093011449 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 741093011450 putative active site [active] 741093011451 substrate binding site [chemical binding]; other site 741093011452 putative cosubstrate binding site; other site 741093011453 catalytic site [active] 741093011454 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 741093011455 substrate binding site [chemical binding]; other site 741093011456 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 741093011457 putative RNA binding site [nucleotide binding]; other site 741093011458 16S rRNA methyltransferase B; Provisional; Region: PRK10901 741093011459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093011460 S-adenosylmethionine binding site [chemical binding]; other site 741093011461 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 741093011462 TrkA-N domain; Region: TrkA_N; pfam02254 741093011463 TrkA-C domain; Region: TrkA_C; pfam02080 741093011464 TrkA-N domain; Region: TrkA_N; pfam02254 741093011465 TrkA-C domain; Region: TrkA_C; pfam02080 741093011466 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 741093011467 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 741093011468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 741093011469 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 741093011470 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 741093011471 DNA binding residues [nucleotide binding] 741093011472 dimer interface [polypeptide binding]; other site 741093011473 metal binding site [ion binding]; metal-binding site 741093011474 hypothetical protein; Provisional; Region: PRK10203 741093011475 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 741093011476 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 741093011477 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 741093011478 alphaNTD homodimer interface [polypeptide binding]; other site 741093011479 alphaNTD - beta interaction site [polypeptide binding]; other site 741093011480 alphaNTD - beta' interaction site [polypeptide binding]; other site 741093011481 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 741093011482 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 741093011483 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 741093011484 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093011485 RNA binding surface [nucleotide binding]; other site 741093011486 30S ribosomal protein S11; Validated; Region: PRK05309 741093011487 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 741093011488 30S ribosomal protein S13; Region: bact_S13; TIGR03631 741093011489 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 741093011490 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 741093011491 SecY translocase; Region: SecY; pfam00344 741093011492 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 741093011493 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 741093011494 23S rRNA binding site [nucleotide binding]; other site 741093011495 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 741093011496 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 741093011497 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 741093011498 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 741093011499 23S rRNA interface [nucleotide binding]; other site 741093011500 5S rRNA interface [nucleotide binding]; other site 741093011501 L27 interface [polypeptide binding]; other site 741093011502 L5 interface [polypeptide binding]; other site 741093011503 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 741093011504 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 741093011505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 741093011506 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 741093011507 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 741093011508 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 741093011509 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 741093011510 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 741093011511 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 741093011512 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 741093011513 RNA binding site [nucleotide binding]; other site 741093011514 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 741093011515 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 741093011516 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 741093011517 23S rRNA interface [nucleotide binding]; other site 741093011518 putative translocon interaction site; other site 741093011519 signal recognition particle (SRP54) interaction site; other site 741093011520 L23 interface [polypeptide binding]; other site 741093011521 trigger factor interaction site; other site 741093011522 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 741093011523 23S rRNA interface [nucleotide binding]; other site 741093011524 5S rRNA interface [nucleotide binding]; other site 741093011525 putative antibiotic binding site [chemical binding]; other site 741093011526 L25 interface [polypeptide binding]; other site 741093011527 L27 interface [polypeptide binding]; other site 741093011528 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 741093011529 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 741093011530 G-X-X-G motif; other site 741093011531 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 741093011532 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 741093011533 protein-rRNA interface [nucleotide binding]; other site 741093011534 putative translocon binding site; other site 741093011535 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 741093011536 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 741093011537 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 741093011538 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 741093011539 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 741093011540 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 741093011541 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 741093011542 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 741093011543 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 741093011544 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 741093011545 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 741093011546 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 741093011547 heme binding site [chemical binding]; other site 741093011548 ferroxidase pore; other site 741093011549 ferroxidase diiron center [ion binding]; other site 741093011550 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 741093011551 elongation factor Tu; Reviewed; Region: PRK00049 741093011552 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 741093011553 G1 box; other site 741093011554 GEF interaction site [polypeptide binding]; other site 741093011555 GTP/Mg2+ binding site [chemical binding]; other site 741093011556 Switch I region; other site 741093011557 G2 box; other site 741093011558 G3 box; other site 741093011559 Switch II region; other site 741093011560 G4 box; other site 741093011561 G5 box; other site 741093011562 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 741093011563 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 741093011564 Antibiotic Binding Site [chemical binding]; other site 741093011565 elongation factor G; Reviewed; Region: PRK00007 741093011566 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 741093011567 G1 box; other site 741093011568 putative GEF interaction site [polypeptide binding]; other site 741093011569 GTP/Mg2+ binding site [chemical binding]; other site 741093011570 Switch I region; other site 741093011571 G2 box; other site 741093011572 G3 box; other site 741093011573 Switch II region; other site 741093011574 G4 box; other site 741093011575 G5 box; other site 741093011576 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 741093011577 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 741093011578 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 741093011579 30S ribosomal protein S7; Validated; Region: PRK05302 741093011580 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 741093011581 S17 interaction site [polypeptide binding]; other site 741093011582 S8 interaction site; other site 741093011583 16S rRNA interaction site [nucleotide binding]; other site 741093011584 streptomycin interaction site [chemical binding]; other site 741093011585 23S rRNA interaction site [nucleotide binding]; other site 741093011586 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 741093011587 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 741093011588 sulfur relay protein TusC; Validated; Region: PRK00211 741093011589 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 741093011590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 741093011591 YheO-like PAS domain; Region: PAS_6; pfam08348 741093011592 HTH domain; Region: HTH_22; pfam13309 741093011593 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 741093011594 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 741093011595 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741093011596 phi X174 lysis protein; Provisional; Region: PRK02793 741093011597 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 741093011598 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741093011599 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 741093011600 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 741093011601 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 741093011602 TrkA-N domain; Region: TrkA_N; pfam02254 741093011603 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 741093011604 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 741093011605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093011606 Walker A/P-loop; other site 741093011607 ATP binding site [chemical binding]; other site 741093011608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741093011609 ABC transporter signature motif; other site 741093011610 Walker B; other site 741093011611 D-loop; other site 741093011612 ABC transporter; Region: ABC_tran_2; pfam12848 741093011613 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741093011614 putative hydrolase; Provisional; Region: PRK10985 741093011615 hypothetical protein; Provisional; Region: PRK04966 741093011616 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 741093011617 active site 741093011618 hypothetical protein; Provisional; Region: PRK10738 741093011619 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 741093011620 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 741093011621 ligand binding site [chemical binding]; other site 741093011622 flexible hinge region; other site 741093011623 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741093011624 putative switch regulator; other site 741093011625 non-specific DNA interactions [nucleotide binding]; other site 741093011626 DNA binding site [nucleotide binding] 741093011627 sequence specific DNA binding site [nucleotide binding]; other site 741093011628 putative cAMP binding site [chemical binding]; other site 741093011629 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 741093011630 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 741093011631 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741093011632 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 741093011633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741093011634 inhibitor-cofactor binding pocket; inhibition site 741093011635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093011636 catalytic residue [active] 741093011637 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 741093011638 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 741093011639 glutamine binding [chemical binding]; other site 741093011640 catalytic triad [active] 741093011641 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 741093011642 cell filamentation protein Fic; Provisional; Region: PRK10347 741093011643 hypothetical protein; Provisional; Region: PRK10204 741093011644 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 741093011645 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 741093011646 substrate binding site [chemical binding]; other site 741093011647 putative transporter; Provisional; Region: PRK03699 741093011648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093011649 putative substrate translocation pore; other site 741093011650 nitrite reductase subunit NirD; Provisional; Region: PRK14989 741093011651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093011652 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 741093011653 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 741093011654 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741093011655 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 741093011656 nitrite transporter NirC; Provisional; Region: PRK11562 741093011657 siroheme synthase; Provisional; Region: cysG; PRK10637 741093011658 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 741093011659 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 741093011660 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 741093011661 active site 741093011662 SAM binding site [chemical binding]; other site 741093011663 homodimer interface [polypeptide binding]; other site 741093011664 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 741093011665 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 741093011666 hypothetical protein; Provisional; Region: PHA02764 741093011667 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 741093011668 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 741093011669 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 741093011670 dimer interface [polypeptide binding]; other site 741093011671 active site 741093011672 fructoselysine 3-epimerase; Provisional; Region: PRK09856 741093011673 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 741093011674 AP (apurinic/apyrimidinic) site pocket; other site 741093011675 DNA interaction; other site 741093011676 Metal-binding active site; metal-binding site 741093011677 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 741093011678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093011679 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 741093011680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093011681 DNA-binding site [nucleotide binding]; DNA binding site 741093011682 UTRA domain; Region: UTRA; pfam07702 741093011683 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 741093011684 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 741093011685 active site 741093011686 HIGH motif; other site 741093011687 dimer interface [polypeptide binding]; other site 741093011688 KMSKS motif; other site 741093011689 phosphoglycolate phosphatase; Provisional; Region: PRK13222 741093011690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093011691 motif II; other site 741093011692 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 741093011693 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 741093011694 substrate binding site [chemical binding]; other site 741093011695 hexamer interface [polypeptide binding]; other site 741093011696 metal binding site [ion binding]; metal-binding site 741093011697 DNA adenine methylase; Provisional; Region: PRK10904 741093011698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 741093011699 cell division protein DamX; Validated; Region: PRK10905 741093011700 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 741093011701 active site 741093011702 dimer interface [polypeptide binding]; other site 741093011703 metal binding site [ion binding]; metal-binding site 741093011704 shikimate kinase; Reviewed; Region: aroK; PRK00131 741093011705 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 741093011706 ADP binding site [chemical binding]; other site 741093011707 magnesium binding site [ion binding]; other site 741093011708 putative shikimate binding site; other site 741093011709 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 741093011710 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741093011711 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741093011712 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 741093011713 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 741093011714 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 741093011715 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 741093011716 Transglycosylase; Region: Transgly; pfam00912 741093011717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 741093011718 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 741093011719 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 741093011720 ADP-ribose binding site [chemical binding]; other site 741093011721 dimer interface [polypeptide binding]; other site 741093011722 active site 741093011723 nudix motif; other site 741093011724 metal binding site [ion binding]; metal-binding site 741093011725 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 741093011726 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 741093011727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093011728 motif II; other site 741093011729 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093011730 RNA binding surface [nucleotide binding]; other site 741093011731 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 741093011732 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 741093011733 dimerization interface [polypeptide binding]; other site 741093011734 domain crossover interface; other site 741093011735 redox-dependent activation switch; other site 741093011736 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 741093011737 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 741093011738 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 741093011739 active site 741093011740 substrate-binding site [chemical binding]; other site 741093011741 metal-binding site [ion binding] 741093011742 ATP binding site [chemical binding]; other site 741093011743 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 741093011744 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093011745 dimerization interface [polypeptide binding]; other site 741093011746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093011747 dimer interface [polypeptide binding]; other site 741093011748 phosphorylation site [posttranslational modification] 741093011749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093011750 ATP binding site [chemical binding]; other site 741093011751 G-X-G motif; other site 741093011752 osmolarity response regulator; Provisional; Region: ompR; PRK09468 741093011753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093011754 active site 741093011755 phosphorylation site [posttranslational modification] 741093011756 intermolecular recognition site; other site 741093011757 dimerization interface [polypeptide binding]; other site 741093011758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093011759 DNA binding site [nucleotide binding] 741093011760 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 741093011761 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 741093011762 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 741093011763 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 741093011764 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 741093011765 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 741093011766 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 741093011767 RNA binding site [nucleotide binding]; other site 741093011768 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 741093011769 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 741093011770 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 741093011771 G1 box; other site 741093011772 GTP/Mg2+ binding site [chemical binding]; other site 741093011773 Switch I region; other site 741093011774 G2 box; other site 741093011775 G3 box; other site 741093011776 Switch II region; other site 741093011777 G4 box; other site 741093011778 G5 box; other site 741093011779 Nucleoside recognition; Region: Gate; pfam07670 741093011780 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 741093011781 Nucleoside recognition; Region: Gate; pfam07670 741093011782 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 741093011783 putative transposase; Provisional; Region: PRK09857 741093011784 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 741093011785 carboxylesterase BioH; Provisional; Region: PRK10349 741093011786 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 741093011787 DNA utilization protein GntX; Provisional; Region: PRK11595 741093011788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093011789 active site 741093011790 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 741093011791 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 741093011792 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 741093011793 high-affinity gluconate transporter; Provisional; Region: PRK14984 741093011794 gluconate transporter; Region: gntP; TIGR00791 741093011795 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 741093011796 4-alpha-glucanotransferase; Region: malQ; TIGR00217 741093011797 maltodextrin phosphorylase; Provisional; Region: PRK14985 741093011798 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 741093011799 homodimer interface [polypeptide binding]; other site 741093011800 active site pocket [active] 741093011801 transcriptional regulator MalT; Provisional; Region: PRK04841 741093011802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093011803 DNA binding residues [nucleotide binding] 741093011804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 741093011805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741093011806 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 741093011807 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 741093011808 putative active site [active] 741093011809 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 741093011810 hypothetical protein; Reviewed; Region: PRK09588 741093011811 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 741093011812 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 741093011813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093011814 Walker A motif; other site 741093011815 ATP binding site [chemical binding]; other site 741093011816 Walker B motif; other site 741093011817 arginine finger; other site 741093011818 intramembrane serine protease GlpG; Provisional; Region: PRK10907 741093011819 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 741093011820 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 741093011821 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 741093011822 active site residue [active] 741093011823 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 741093011824 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 741093011825 glycogen phosphorylase; Provisional; Region: PRK14986 741093011826 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 741093011827 homodimer interface [polypeptide binding]; other site 741093011828 active site pocket [active] 741093011829 glycogen synthase; Provisional; Region: glgA; PRK00654 741093011830 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 741093011831 ADP-binding pocket [chemical binding]; other site 741093011832 homodimer interface [polypeptide binding]; other site 741093011833 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 741093011834 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 741093011835 ligand binding site; other site 741093011836 oligomer interface; other site 741093011837 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 741093011838 sulfate 1 binding site; other site 741093011839 glycogen debranching enzyme; Provisional; Region: PRK03705 741093011840 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 741093011841 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 741093011842 active site 741093011843 catalytic site [active] 741093011844 glycogen branching enzyme; Provisional; Region: PRK05402 741093011845 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 741093011846 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 741093011847 active site 741093011848 catalytic site [active] 741093011849 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 741093011850 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 741093011851 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741093011852 putative antibiotic transporter; Provisional; Region: PRK10739 741093011853 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 741093011854 DNA protecting protein DprA; Region: dprA; TIGR00732 741093011855 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741093011856 non-specific DNA interactions [nucleotide binding]; other site 741093011857 DNA binding site [nucleotide binding] 741093011858 sequence specific DNA binding site [nucleotide binding]; other site 741093011859 putative cAMP binding site [chemical binding]; other site 741093011860 low affinity gluconate transporter; Provisional; Region: PRK10472 741093011861 gluconate transporter; Region: gntP; TIGR00791 741093011862 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 741093011863 ATP-binding site [chemical binding]; other site 741093011864 Gluconate-6-phosphate binding site [chemical binding]; other site 741093011865 Shikimate kinase; Region: SKI; pfam01202 741093011866 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 741093011867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093011868 DNA binding site [nucleotide binding] 741093011869 domain linker motif; other site 741093011870 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 741093011871 putative ligand binding site [chemical binding]; other site 741093011872 putative dimerization interface [polypeptide binding]; other site 741093011873 Pirin-related protein [General function prediction only]; Region: COG1741 741093011874 Pirin; Region: Pirin; pfam02678 741093011875 putative oxidoreductase; Provisional; Region: PRK10206 741093011876 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741093011877 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741093011878 putative acetyltransferase YhhY; Provisional; Region: PRK10140 741093011879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093011880 Coenzyme A binding pocket [chemical binding]; other site 741093011881 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 741093011882 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 741093011883 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 741093011884 hypothetical protein; Provisional; Region: PRK10350 741093011885 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 741093011886 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 741093011887 putative active site [active] 741093011888 catalytic site [active] 741093011889 putative metal binding site [ion binding]; other site 741093011890 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741093011891 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741093011892 Walker A/P-loop; other site 741093011893 ATP binding site [chemical binding]; other site 741093011894 Q-loop/lid; other site 741093011895 ABC transporter signature motif; other site 741093011896 Walker B; other site 741093011897 D-loop; other site 741093011898 H-loop/switch region; other site 741093011899 TOBE domain; Region: TOBE_2; pfam08402 741093011900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741093011901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093011902 dimer interface [polypeptide binding]; other site 741093011903 conserved gate region; other site 741093011904 putative PBP binding loops; other site 741093011905 ABC-ATPase subunit interface; other site 741093011906 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 741093011907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093011908 dimer interface [polypeptide binding]; other site 741093011909 conserved gate region; other site 741093011910 putative PBP binding loops; other site 741093011911 ABC-ATPase subunit interface; other site 741093011912 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 741093011913 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741093011914 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 741093011915 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 741093011916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 741093011917 binding surface 741093011918 TPR motif; other site 741093011919 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 741093011920 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 741093011921 Walker A/P-loop; other site 741093011922 ATP binding site [chemical binding]; other site 741093011923 Q-loop/lid; other site 741093011924 ABC transporter signature motif; other site 741093011925 Walker B; other site 741093011926 D-loop; other site 741093011927 H-loop/switch region; other site 741093011928 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 741093011929 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 741093011930 Walker A/P-loop; other site 741093011931 ATP binding site [chemical binding]; other site 741093011932 Q-loop/lid; other site 741093011933 ABC transporter signature motif; other site 741093011934 Walker B; other site 741093011935 D-loop; other site 741093011936 H-loop/switch region; other site 741093011937 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 741093011938 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 741093011939 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 741093011940 TM-ABC transporter signature motif; other site 741093011941 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093011942 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 741093011943 TM-ABC transporter signature motif; other site 741093011944 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 741093011945 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 741093011946 dimerization interface [polypeptide binding]; other site 741093011947 ligand binding site [chemical binding]; other site 741093011948 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 741093011949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 741093011950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 741093011951 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 741093011952 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 741093011953 dimerization interface [polypeptide binding]; other site 741093011954 ligand binding site [chemical binding]; other site 741093011955 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 741093011956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741093011957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741093011958 DNA binding residues [nucleotide binding] 741093011959 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 741093011960 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 741093011961 cell division protein FtsE; Provisional; Region: PRK10908 741093011962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093011963 Walker A/P-loop; other site 741093011964 ATP binding site [chemical binding]; other site 741093011965 Q-loop/lid; other site 741093011966 ABC transporter signature motif; other site 741093011967 Walker B; other site 741093011968 D-loop; other site 741093011969 H-loop/switch region; other site 741093011970 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 741093011971 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 741093011972 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 741093011973 P loop; other site 741093011974 GTP binding site [chemical binding]; other site 741093011975 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 741093011976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093011977 S-adenosylmethionine binding site [chemical binding]; other site 741093011978 hypothetical protein; Provisional; Region: PRK10910 741093011979 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 741093011980 Predicted membrane protein [Function unknown]; Region: COG3714 741093011981 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 741093011982 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 741093011983 metal-binding site [ion binding] 741093011984 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741093011985 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 741093011986 CPxP motif; other site 741093011987 hypothetical protein; Provisional; Region: PRK11212 741093011988 hypothetical protein; Provisional; Region: PRK11615 741093011989 major facilitator superfamily transporter; Provisional; Region: PRK05122 741093011990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093011991 putative substrate translocation pore; other site 741093011992 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 741093011993 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741093011994 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 741093011995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093011996 S-adenosylmethionine binding site [chemical binding]; other site 741093011997 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 741093011998 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 741093011999 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 741093012000 putative acyl-acceptor binding pocket; other site 741093012001 Phosphopantetheine attachment site; Region: PP-binding; cl09936 741093012002 acyl carrier protein; Provisional; Region: PRK05350 741093012003 Predicted membrane protein [Function unknown]; Region: COG4648 741093012004 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 741093012005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741093012006 acyl-activating enzyme (AAE) consensus motif; other site 741093012007 active site 741093012008 AMP binding site [chemical binding]; other site 741093012009 CoA binding site [chemical binding]; other site 741093012010 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 741093012011 active site 2 [active] 741093012012 active site 1 [active] 741093012013 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 741093012014 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 741093012015 Ligand binding site; other site 741093012016 Putative Catalytic site; other site 741093012017 DXD motif; other site 741093012018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741093012019 putative acyl-acceptor binding pocket; other site 741093012020 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 741093012021 active site 741093012022 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 741093012023 Predicted exporter [General function prediction only]; Region: COG4258 741093012024 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 741093012025 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 741093012026 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741093012027 dimer interface [polypeptide binding]; other site 741093012028 active site 741093012029 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 741093012030 putative active site 1 [active] 741093012031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741093012032 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 741093012033 NAD(P) binding site [chemical binding]; other site 741093012034 active site 741093012035 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 741093012036 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741093012037 dimer interface [polypeptide binding]; other site 741093012038 active site 741093012039 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 741093012040 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 741093012041 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741093012042 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 741093012043 substrate binding site [chemical binding]; other site 741093012044 nickel transporter permease NikB; Provisional; Region: PRK10352 741093012045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093012046 dimer interface [polypeptide binding]; other site 741093012047 conserved gate region; other site 741093012048 putative PBP binding loops; other site 741093012049 ABC-ATPase subunit interface; other site 741093012050 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 741093012051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093012052 dimer interface [polypeptide binding]; other site 741093012053 conserved gate region; other site 741093012054 putative PBP binding loops; other site 741093012055 ABC-ATPase subunit interface; other site 741093012056 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 741093012057 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093012058 Walker A/P-loop; other site 741093012059 ATP binding site [chemical binding]; other site 741093012060 Q-loop/lid; other site 741093012061 ABC transporter signature motif; other site 741093012062 Walker B; other site 741093012063 D-loop; other site 741093012064 H-loop/switch region; other site 741093012065 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741093012066 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 741093012067 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093012068 Walker A/P-loop; other site 741093012069 ATP binding site [chemical binding]; other site 741093012070 Q-loop/lid; other site 741093012071 ABC transporter signature motif; other site 741093012072 Walker B; other site 741093012073 D-loop; other site 741093012074 H-loop/switch region; other site 741093012075 nickel responsive regulator; Provisional; Region: PRK02967 741093012076 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 741093012077 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741093012078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093012079 DNA-binding site [nucleotide binding]; DNA binding site 741093012080 UTRA domain; Region: UTRA; pfam07702 741093012081 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093012082 active site 741093012083 phosphorylation site [posttranslational modification] 741093012084 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 741093012085 active site 741093012086 P-loop; other site 741093012087 phosphorylation site [posttranslational modification] 741093012088 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 741093012089 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 741093012090 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 741093012091 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 741093012092 putative N- and C-terminal domain interface [polypeptide binding]; other site 741093012093 putative active site [active] 741093012094 putative MgATP binding site [chemical binding]; other site 741093012095 catalytic site [active] 741093012096 metal binding site [ion binding]; metal-binding site 741093012097 putative carbohydrate binding site [chemical binding]; other site 741093012098 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093012099 dimerization domain swap beta strand [polypeptide binding]; other site 741093012100 regulatory protein interface [polypeptide binding]; other site 741093012101 active site 741093012102 regulatory phosphorylation site [posttranslational modification]; other site 741093012103 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 741093012104 intersubunit interface [polypeptide binding]; other site 741093012105 active site 741093012106 zinc binding site [ion binding]; other site 741093012107 Na+ binding site [ion binding]; other site 741093012108 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 741093012109 HicB family; Region: HicB; pfam05534 741093012110 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741093012111 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 741093012112 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741093012113 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741093012114 Walker A/P-loop; other site 741093012115 ATP binding site [chemical binding]; other site 741093012116 Q-loop/lid; other site 741093012117 ABC transporter signature motif; other site 741093012118 Walker B; other site 741093012119 D-loop; other site 741093012120 H-loop/switch region; other site 741093012121 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741093012122 Walker A/P-loop; other site 741093012123 ATP binding site [chemical binding]; other site 741093012124 Q-loop/lid; other site 741093012125 ABC transporter signature motif; other site 741093012126 Walker B; other site 741093012127 D-loop; other site 741093012128 H-loop/switch region; other site 741093012129 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741093012130 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 741093012131 HlyD family secretion protein; Region: HlyD; pfam00529 741093012132 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093012133 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093012134 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 741093012135 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 741093012136 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 741093012137 Predicted flavoproteins [General function prediction only]; Region: COG2081 741093012138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093012139 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 741093012140 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 741093012141 universal stress protein UspB; Provisional; Region: PRK04960 741093012142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093012143 Ligand Binding Site [chemical binding]; other site 741093012144 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 741093012145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012146 POT family; Region: PTR2; pfam00854 741093012147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093012148 S-adenosylmethionine binding site [chemical binding]; other site 741093012149 oligopeptidase A; Provisional; Region: PRK10911 741093012150 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 741093012151 active site 741093012152 Zn binding site [ion binding]; other site 741093012153 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 741093012154 glutathione reductase; Validated; Region: PRK06116 741093012155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741093012156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093012157 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741093012158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093012159 dimerization interface [polypeptide binding]; other site 741093012160 putative DNA binding site [nucleotide binding]; other site 741093012161 putative Zn2+ binding site [ion binding]; other site 741093012162 arsenical pump membrane protein; Provisional; Region: PRK15445 741093012163 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 741093012164 transmembrane helices; other site 741093012165 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 741093012166 ArsC family; Region: ArsC; pfam03960 741093012167 catalytic residues [active] 741093012168 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 741093012169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741093012170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093012171 DNA binding residues [nucleotide binding] 741093012172 dimerization interface [polypeptide binding]; other site 741093012173 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 741093012174 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 741093012175 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 741093012176 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 741093012177 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093012178 N-terminal plug; other site 741093012179 ligand-binding site [chemical binding]; other site 741093012180 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 741093012181 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 741093012182 putative hemin binding site; other site 741093012183 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 741093012184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093012185 FeS/SAM binding site; other site 741093012186 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 741093012187 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 741093012188 NADH(P)-binding; Region: NAD_binding_10; pfam13460 741093012189 NAD(P) binding site [chemical binding]; other site 741093012190 putative active site [active] 741093012191 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741093012192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741093012193 ABC-ATPase subunit interface; other site 741093012194 dimer interface [polypeptide binding]; other site 741093012195 putative PBP binding regions; other site 741093012196 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 741093012197 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741093012198 Walker A/P-loop; other site 741093012199 ATP binding site [chemical binding]; other site 741093012200 Q-loop/lid; other site 741093012201 ABC transporter signature motif; other site 741093012202 Walker B; other site 741093012203 D-loop; other site 741093012204 H-loop/switch region; other site 741093012205 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 741093012206 MgtC family; Region: MgtC; pfam02308 741093012207 acid-resistance protein; Provisional; Region: hdeB; PRK11566 741093012208 acid-resistance protein; Provisional; Region: PRK10208 741093012209 acid-resistance membrane protein; Provisional; Region: PRK10209 741093012210 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 741093012211 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 741093012212 pyruvate kinase; Provisional; Region: PRK05826 741093012213 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 741093012214 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093012215 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093012216 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 741093012217 Protein export membrane protein; Region: SecD_SecF; cl14618 741093012218 transcriptional regulator YdeO; Provisional; Region: PRK09940 741093012219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093012220 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 741093012221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093012222 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 741093012223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093012224 catalytic residue [active] 741093012225 Haem-binding domain; Region: Haem_bd; pfam14376 741093012226 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 741093012227 trehalase; Provisional; Region: treF; PRK13270 741093012228 Trehalase; Region: Trehalase; pfam01204 741093012229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741093012230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093012231 DNA binding residues [nucleotide binding] 741093012232 dimerization interface [polypeptide binding]; other site 741093012233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093012234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093012235 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 741093012236 putative effector binding pocket; other site 741093012237 putative dimerization interface [polypeptide binding]; other site 741093012238 inner membrane protein YhjD; Region: TIGR00766 741093012239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012240 metabolite-proton symporter; Region: 2A0106; TIGR00883 741093012241 putative substrate translocation pore; other site 741093012242 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 741093012243 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 741093012244 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093012245 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093012246 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 741093012247 substrate binding site [chemical binding]; other site 741093012248 ATP binding site [chemical binding]; other site 741093012249 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 741093012250 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741093012251 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 741093012252 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741093012253 putative diguanylate cyclase; Provisional; Region: PRK13561 741093012254 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741093012255 metal binding site [ion binding]; metal-binding site 741093012256 active site 741093012257 I-site; other site 741093012258 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093012259 TPR repeat; Region: TPR_11; pfam13414 741093012260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093012261 binding surface 741093012262 TPR motif; other site 741093012263 Tetratricopeptide repeat; Region: TPR_16; pfam13432 741093012264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093012265 binding surface 741093012266 TPR repeat; Region: TPR_11; pfam13414 741093012267 TPR motif; other site 741093012268 Tetratricopeptide repeat; Region: TPR_16; pfam13432 741093012269 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 741093012270 endo-1,4-D-glucanase; Provisional; Region: PRK11097 741093012271 cellulose synthase regulator protein; Provisional; Region: PRK11114 741093012272 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 741093012273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 741093012274 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 741093012275 DXD motif; other site 741093012276 PilZ domain; Region: PilZ; pfam07238 741093012277 cell division protein; Provisional; Region: PRK10037 741093012278 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 741093012279 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 741093012280 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 741093012281 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 741093012282 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 741093012283 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 741093012284 serine transporter; Region: stp; TIGR00814 741093012285 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 741093012286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093012287 Walker A/P-loop; other site 741093012288 ATP binding site [chemical binding]; other site 741093012289 Q-loop/lid; other site 741093012290 ABC transporter signature motif; other site 741093012291 Walker B; other site 741093012292 D-loop; other site 741093012293 H-loop/switch region; other site 741093012294 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741093012295 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 741093012296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093012297 Walker A/P-loop; other site 741093012298 ATP binding site [chemical binding]; other site 741093012299 Q-loop/lid; other site 741093012300 ABC transporter signature motif; other site 741093012301 Walker B; other site 741093012302 D-loop; other site 741093012303 H-loop/switch region; other site 741093012304 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741093012305 dipeptide transporter; Provisional; Region: PRK10913 741093012306 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741093012307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093012308 dimer interface [polypeptide binding]; other site 741093012309 conserved gate region; other site 741093012310 putative PBP binding loops; other site 741093012311 ABC-ATPase subunit interface; other site 741093012312 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741093012313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093012314 dimer interface [polypeptide binding]; other site 741093012315 conserved gate region; other site 741093012316 putative PBP binding loops; other site 741093012317 ABC-ATPase subunit interface; other site 741093012318 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741093012319 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 741093012320 peptide binding site [polypeptide binding]; other site 741093012321 phosphoethanolamine transferase; Provisional; Region: PRK11560 741093012322 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741093012323 Sulfatase; Region: Sulfatase; pfam00884 741093012324 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 741093012325 Fimbrial protein; Region: Fimbrial; cl01416 741093012326 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 741093012327 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093012328 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093012329 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 741093012330 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 741093012331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012332 putative substrate translocation pore; other site 741093012333 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 741093012334 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 741093012335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741093012336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093012337 Coenzyme A binding pocket [chemical binding]; other site 741093012338 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 741093012339 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 741093012340 molybdopterin cofactor binding site [chemical binding]; other site 741093012341 substrate binding site [chemical binding]; other site 741093012342 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 741093012343 molybdopterin cofactor binding site; other site 741093012344 putative outer membrane lipoprotein; Provisional; Region: PRK10510 741093012345 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093012346 ligand binding site [chemical binding]; other site 741093012347 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 741093012348 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 741093012349 dimerization interface [polypeptide binding]; other site 741093012350 ligand binding site [chemical binding]; other site 741093012351 NADP binding site [chemical binding]; other site 741093012352 catalytic site [active] 741093012353 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 741093012354 Predicted transcriptional regulator [Transcription]; Region: COG2944 741093012355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093012356 non-specific DNA binding site [nucleotide binding]; other site 741093012357 salt bridge; other site 741093012358 sequence-specific DNA binding site [nucleotide binding]; other site 741093012359 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741093012360 DNA-binding site [nucleotide binding]; DNA binding site 741093012361 RNA-binding motif; other site 741093012362 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 741093012363 DALR anticodon binding domain; Region: DALR_1; pfam05746 741093012364 anticodon binding site; other site 741093012365 tRNA binding surface [nucleotide binding]; other site 741093012366 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 741093012367 dimer interface [polypeptide binding]; other site 741093012368 motif 1; other site 741093012369 active site 741093012370 motif 2; other site 741093012371 motif 3; other site 741093012372 YsaB-like lipoprotein; Region: YsaB; pfam13983 741093012373 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 741093012374 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741093012375 hypothetical protein; Provisional; Region: PRK11383 741093012376 yiaA/B two helix domain; Region: YiaAB; pfam05360 741093012377 yiaA/B two helix domain; Region: YiaAB; pfam05360 741093012378 hypothetical protein; Provisional; Region: PRK11403 741093012379 yiaA/B two helix domain; Region: YiaAB; pfam05360 741093012380 xylulokinase; Provisional; Region: PRK15027 741093012381 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 741093012382 N- and C-terminal domain interface [polypeptide binding]; other site 741093012383 active site 741093012384 MgATP binding site [chemical binding]; other site 741093012385 catalytic site [active] 741093012386 metal binding site [ion binding]; metal-binding site 741093012387 xylulose binding site [chemical binding]; other site 741093012388 homodimer interface [polypeptide binding]; other site 741093012389 xylose isomerase; Provisional; Region: PRK05474 741093012390 xylose isomerase; Region: xylose_isom_A; TIGR02630 741093012391 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 741093012392 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 741093012393 putative ligand binding site [chemical binding]; other site 741093012394 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 741093012395 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093012396 Walker A/P-loop; other site 741093012397 ATP binding site [chemical binding]; other site 741093012398 Q-loop/lid; other site 741093012399 ABC transporter signature motif; other site 741093012400 Walker B; other site 741093012401 D-loop; other site 741093012402 H-loop/switch region; other site 741093012403 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093012404 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093012405 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093012406 TM-ABC transporter signature motif; other site 741093012407 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 741093012408 putative dimerization interface [polypeptide binding]; other site 741093012409 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741093012410 putative ligand binding site [chemical binding]; other site 741093012411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093012412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093012413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093012414 hypothetical protein; Provisional; Region: PRK10356 741093012415 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 741093012416 alpha-amylase; Reviewed; Region: malS; PRK09505 741093012417 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 741093012418 active site 741093012419 catalytic site [active] 741093012420 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 741093012421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093012422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093012423 homodimer interface [polypeptide binding]; other site 741093012424 catalytic residue [active] 741093012425 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 741093012426 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 741093012427 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741093012428 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741093012429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093012430 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741093012431 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741093012432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 741093012433 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 741093012434 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 741093012435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741093012436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093012437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741093012438 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 741093012439 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093012440 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093012441 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 741093012442 FlxA-like protein; Region: FlxA; pfam14282 741093012443 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 741093012444 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 741093012445 NAD(P) binding site [chemical binding]; other site 741093012446 catalytic residues [active] 741093012447 Fic family protein [Function unknown]; Region: COG3177 741093012448 Fic/DOC family; Region: Fic; pfam02661 741093012449 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 741093012450 putative alcohol dehydrogenase; Provisional; Region: PRK09860 741093012451 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 741093012452 dimer interface [polypeptide binding]; other site 741093012453 active site 741093012454 metal binding site [ion binding]; metal-binding site 741093012455 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 741093012456 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 741093012457 G1 box; other site 741093012458 putative GEF interaction site [polypeptide binding]; other site 741093012459 GTP/Mg2+ binding site [chemical binding]; other site 741093012460 Switch I region; other site 741093012461 G2 box; other site 741093012462 G3 box; other site 741093012463 Switch II region; other site 741093012464 G4 box; other site 741093012465 G5 box; other site 741093012466 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 741093012467 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 741093012468 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 741093012469 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 741093012470 selenocysteine synthase; Provisional; Region: PRK04311 741093012471 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 741093012472 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 741093012473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741093012474 catalytic residue [active] 741093012475 putative glutathione S-transferase; Provisional; Region: PRK10357 741093012476 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 741093012477 putative C-terminal domain interface [polypeptide binding]; other site 741093012478 putative GSH binding site (G-site) [chemical binding]; other site 741093012479 putative dimer interface [polypeptide binding]; other site 741093012480 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 741093012481 dimer interface [polypeptide binding]; other site 741093012482 N-terminal domain interface [polypeptide binding]; other site 741093012483 putative substrate binding pocket (H-site) [chemical binding]; other site 741093012484 PAAR motif; Region: PAAR_motif; cl15808 741093012485 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093012486 RHS Repeat; Region: RHS_repeat; pfam05593 741093012487 RHS Repeat; Region: RHS_repeat; pfam05593 741093012488 RHS Repeat; Region: RHS_repeat; pfam05593 741093012489 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093012490 RHS Repeat; Region: RHS_repeat; pfam05593 741093012491 RHS Repeat; Region: RHS_repeat; pfam05593 741093012492 RHS protein; Region: RHS; pfam03527 741093012493 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093012494 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741093012495 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 741093012496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093012497 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093012498 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 741093012499 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 741093012500 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 741093012501 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 741093012502 active site 741093012503 P-loop; other site 741093012504 phosphorylation site [posttranslational modification] 741093012505 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093012506 active site 741093012507 phosphorylation site [posttranslational modification] 741093012508 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 741093012509 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741093012510 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741093012511 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 741093012512 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 741093012513 hypothetical protein; Provisional; Region: PRK11020 741093012514 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 741093012515 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 741093012516 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 741093012517 trimer interface [polypeptide binding]; other site 741093012518 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 741093012519 trimer interface [polypeptide binding]; other site 741093012520 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 741093012521 trimer interface [polypeptide binding]; other site 741093012522 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 741093012523 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 741093012524 trimer interface [polypeptide binding]; other site 741093012525 Haemagglutinin; Region: HIM; pfam05662 741093012526 Haemagglutinin; Region: HIM; pfam05662 741093012527 YadA-like C-terminal region; Region: YadA; pfam03895 741093012528 L-lactate permease; Provisional; Region: PRK10420 741093012529 glycolate transporter; Provisional; Region: PRK09695 741093012530 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 741093012531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093012532 DNA-binding site [nucleotide binding]; DNA binding site 741093012533 FCD domain; Region: FCD; pfam07729 741093012534 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 741093012535 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741093012536 phosphate binding site [ion binding]; other site 741093012537 putative rRNA methylase; Provisional; Region: PRK10358 741093012538 serine acetyltransferase; Provisional; Region: cysE; PRK11132 741093012539 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 741093012540 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 741093012541 trimer interface [polypeptide binding]; other site 741093012542 active site 741093012543 substrate binding site [chemical binding]; other site 741093012544 CoA binding site [chemical binding]; other site 741093012545 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 741093012546 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 741093012547 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 741093012548 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 741093012549 SecA binding site; other site 741093012550 Preprotein binding site; other site 741093012551 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 741093012552 GSH binding site [chemical binding]; other site 741093012553 catalytic residues [active] 741093012554 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 741093012555 active site residue [active] 741093012556 phosphoglyceromutase; Provisional; Region: PRK05434 741093012557 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 741093012558 AmiB activator; Provisional; Region: PRK11637 741093012559 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 741093012560 Peptidase family M23; Region: Peptidase_M23; pfam01551 741093012561 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 741093012562 NodB motif; other site 741093012563 putative active site [active] 741093012564 putative catalytic site [active] 741093012565 Zn binding site [ion binding]; other site 741093012566 putative glycosyl transferase; Provisional; Region: PRK10073 741093012567 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 741093012568 active site 741093012569 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 741093012570 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 741093012571 NAD(P) binding site [chemical binding]; other site 741093012572 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 741093012573 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 741093012574 substrate-cofactor binding pocket; other site 741093012575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093012576 catalytic residue [active] 741093012577 hypothetical protein; Provisional; Region: PRK11346 741093012578 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 741093012579 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 741093012580 NADP binding site [chemical binding]; other site 741093012581 homopentamer interface [polypeptide binding]; other site 741093012582 substrate binding site [chemical binding]; other site 741093012583 active site 741093012584 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741093012585 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741093012586 putative active site [active] 741093012587 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741093012588 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741093012589 putative active site [active] 741093012590 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 741093012591 O-antigen ligase RfaL; Provisional; Region: PRK15487 741093012592 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 741093012593 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 741093012594 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 741093012595 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 741093012596 Ligand binding site; other site 741093012597 metal-binding site 741093012598 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 741093012599 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 741093012600 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 741093012601 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 741093012602 Ligand binding site; other site 741093012603 metal-binding site 741093012604 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 741093012605 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 741093012606 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 741093012607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741093012608 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 741093012609 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741093012610 putative active site [active] 741093012611 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 741093012612 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 741093012613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 741093012614 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 741093012615 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 741093012616 active site 741093012617 (T/H)XGH motif; other site 741093012618 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 741093012619 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 741093012620 DNA binding site [nucleotide binding] 741093012621 catalytic residue [active] 741093012622 H2TH interface [polypeptide binding]; other site 741093012623 putative catalytic residues [active] 741093012624 turnover-facilitating residue; other site 741093012625 intercalation triad [nucleotide binding]; other site 741093012626 8OG recognition residue [nucleotide binding]; other site 741093012627 putative reading head residues; other site 741093012628 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 741093012629 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 741093012630 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 741093012631 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 741093012632 hypothetical protein; Reviewed; Region: PRK00024 741093012633 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 741093012634 MPN+ (JAMM) motif; other site 741093012635 Zinc-binding site [ion binding]; other site 741093012636 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 741093012637 Flavoprotein; Region: Flavoprotein; pfam02441 741093012638 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 741093012639 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 741093012640 trimer interface [polypeptide binding]; other site 741093012641 active site 741093012642 division inhibitor protein; Provisional; Region: slmA; PRK09480 741093012643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093012644 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741093012645 active site 741093012646 ribonuclease PH; Reviewed; Region: rph; PRK00173 741093012647 Ribonuclease PH; Region: RNase_PH_bact; cd11362 741093012648 hexamer interface [polypeptide binding]; other site 741093012649 active site 741093012650 hypothetical protein; Provisional; Region: PRK11820 741093012651 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 741093012652 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 741093012653 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 741093012654 BRO family, N-terminal domain; Region: Bro-N; pfam02498 741093012655 Predicted membrane protein [Function unknown]; Region: COG2860 741093012656 UPF0126 domain; Region: UPF0126; pfam03458 741093012657 UPF0126 domain; Region: UPF0126; pfam03458 741093012658 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 741093012659 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 741093012660 nucleotide binding pocket [chemical binding]; other site 741093012661 K-X-D-G motif; other site 741093012662 catalytic site [active] 741093012663 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 741093012664 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 741093012665 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 741093012666 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 741093012667 catalytic site [active] 741093012668 G-X2-G-X-G-K; other site 741093012669 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 741093012670 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 741093012671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741093012672 Zn2+ binding site [ion binding]; other site 741093012673 Mg2+ binding site [ion binding]; other site 741093012674 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 741093012675 synthetase active site [active] 741093012676 NTP binding site [chemical binding]; other site 741093012677 metal binding site [ion binding]; metal-binding site 741093012678 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 741093012679 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 741093012680 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 741093012681 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 741093012682 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 741093012683 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 741093012684 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 741093012685 generic binding surface II; other site 741093012686 ssDNA binding site; other site 741093012687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093012688 ATP binding site [chemical binding]; other site 741093012689 putative Mg++ binding site [ion binding]; other site 741093012690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093012691 nucleotide binding region [chemical binding]; other site 741093012692 ATP-binding site [chemical binding]; other site 741093012693 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 741093012694 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 741093012695 AsmA family; Region: AsmA; pfam05170 741093012696 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 741093012697 putative alpha-glucosidase; Provisional; Region: PRK10658 741093012698 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 741093012699 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 741093012700 active site 741093012701 homotrimer interface [polypeptide binding]; other site 741093012702 catalytic site [active] 741093012703 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 741093012704 putative transporter; Provisional; Region: PRK11462 741093012705 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741093012706 integrase; Provisional; Region: PRK09692 741093012707 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093012708 active site 741093012709 Int/Topo IB signature motif; other site 741093012710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093012711 Transposase; Region: HTH_Tnp_1; cl17663 741093012712 Integrase core domain; Region: rve; pfam00665 741093012713 DDE domain; Region: DDE_Tnp_IS240; pfam13610 741093012714 Integrase core domain; Region: rve_3; pfam13683 741093012715 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 741093012716 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 741093012717 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 741093012718 Transposase; Region: HTH_Tnp_1; pfam01527 741093012719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093012720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093012721 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 741093012722 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 741093012723 homodimer interface [polypeptide binding]; other site 741093012724 putative GKAP docking site [polypeptide binding]; other site 741093012725 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 741093012726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 741093012727 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 741093012728 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 741093012729 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 741093012730 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 741093012731 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 741093012732 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 741093012733 Enterobacterial EspB protein; Region: EspB; pfam05802 741093012734 Uncharacterized conserved protein [Function unknown]; Region: COG5613 741093012735 EspA-like secreted protein; Region: EspA; pfam03433 741093012736 HrpJ-like domain; Region: HrpJ; pfam07201 741093012737 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 741093012738 type III secretion system protein SsaD; Provisional; Region: PRK15367 741093012739 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 741093012740 LysM domain; Region: LysM; pfam01476 741093012741 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 741093012742 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 741093012743 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093012744 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 741093012745 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 741093012746 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 741093012747 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 741093012748 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 741093012749 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 741093012750 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 741093012751 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 741093012752 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 741093012753 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 741093012754 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 741093012755 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 741093012756 Walker A motif/ATP binding site; other site 741093012757 Walker B motif; other site 741093012758 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 741093012759 FHIPEP family; Region: FHIPEP; pfam00771 741093012760 SepZ; Region: SepZ; pfam06066 741093012761 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 741093012762 outer membrane secretin SsaC; Provisional; Region: PRK15346 741093012763 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741093012764 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741093012765 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 741093012766 Tetratricopeptide repeat; Region: TPR_3; pfam07720 741093012767 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 741093012768 negative regulator GrlR; Provisional; Region: PRK14051 741093012769 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 741093012770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093012771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093012772 catalytic residue [active] 741093012773 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 741093012774 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 741093012775 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 741093012776 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 741093012777 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 741093012778 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 741093012779 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 741093012780 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 741093012781 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 741093012782 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 741093012783 EspG protein; Region: EspG; pfam06872 741093012784 SdiA-regulated; Region: SdiA-regulated; cd09971 741093012785 SdiA-regulated; Region: SdiA-regulated; pfam06977 741093012786 putative active site [active] 741093012787 EamA-like transporter family; Region: EamA; pfam00892 741093012788 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 741093012789 EamA-like transporter family; Region: EamA; pfam00892 741093012790 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 741093012791 lipoprotein, YaeC family; Region: TIGR00363 741093012792 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 741093012793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012794 putative substrate translocation pore; other site 741093012795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 741093012796 Predicted transcriptional regulator [Transcription]; Region: COG2944 741093012797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093012798 non-specific DNA binding site [nucleotide binding]; other site 741093012799 salt bridge; other site 741093012800 sequence-specific DNA binding site [nucleotide binding]; other site 741093012801 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 741093012802 cryptic adenine deaminase; Provisional; Region: PRK10027 741093012803 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741093012804 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 741093012805 active site 741093012806 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 741093012807 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 741093012808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012809 putative substrate translocation pore; other site 741093012810 regulatory protein UhpC; Provisional; Region: PRK11663 741093012811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012812 putative substrate translocation pore; other site 741093012813 sensory histidine kinase UhpB; Provisional; Region: PRK11644 741093012814 MASE1; Region: MASE1; pfam05231 741093012815 Histidine kinase; Region: HisKA_3; pfam07730 741093012816 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 741093012817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093012818 active site 741093012819 phosphorylation site [posttranslational modification] 741093012820 intermolecular recognition site; other site 741093012821 dimerization interface [polypeptide binding]; other site 741093012822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093012823 DNA binding residues [nucleotide binding] 741093012824 dimerization interface [polypeptide binding]; other site 741093012825 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 741093012826 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 741093012827 putative valine binding site [chemical binding]; other site 741093012828 dimer interface [polypeptide binding]; other site 741093012829 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 741093012830 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741093012831 PYR/PP interface [polypeptide binding]; other site 741093012832 dimer interface [polypeptide binding]; other site 741093012833 TPP binding site [chemical binding]; other site 741093012834 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741093012835 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 741093012836 TPP-binding site [chemical binding]; other site 741093012837 dimer interface [polypeptide binding]; other site 741093012838 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 741093012839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012840 putative substrate translocation pore; other site 741093012841 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 741093012842 Domain of unknown function (DUF202); Region: DUF202; pfam02656 741093012843 Predicted membrane protein [Function unknown]; Region: COG2149 741093012844 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 741093012845 Sulfatase; Region: Sulfatase; pfam00884 741093012846 putative transporter; Provisional; Region: PRK10484 741093012847 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 741093012848 Na binding site [ion binding]; other site 741093012849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741093012850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093012851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093012852 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 741093012853 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 741093012854 NAD binding site [chemical binding]; other site 741093012855 sugar binding site [chemical binding]; other site 741093012856 divalent metal binding site [ion binding]; other site 741093012857 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093012858 dimer interface [polypeptide binding]; other site 741093012859 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 741093012860 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 741093012861 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093012862 active site turn [active] 741093012863 phosphorylation site [posttranslational modification] 741093012864 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741093012865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093012866 DNA-binding site [nucleotide binding]; DNA binding site 741093012867 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 741093012868 putative transporter; Validated; Region: PRK03818 741093012869 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 741093012870 TrkA-C domain; Region: TrkA_C; pfam02080 741093012871 TrkA-C domain; Region: TrkA_C; pfam02080 741093012872 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 741093012873 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 741093012874 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 741093012875 putative dimer interface [polypeptide binding]; other site 741093012876 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 741093012877 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 741093012878 putative dimer interface [polypeptide binding]; other site 741093012879 hypothetical protein; Provisional; Region: PRK11616 741093012880 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 741093012881 putative oxidoreductase; Provisional; Region: PRK11445 741093012882 hypothetical protein; Provisional; Region: PRK07236 741093012883 hypothetical protein; Provisional; Region: PRK10215 741093012884 sugar phosphate phosphatase; Provisional; Region: PRK10513 741093012885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093012886 active site 741093012887 motif I; other site 741093012888 motif II; other site 741093012889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093012890 hypothetical protein; Provisional; Region: PRK11426 741093012891 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 741093012892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093012893 Mg2+ binding site [ion binding]; other site 741093012894 G-X-G motif; other site 741093012895 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 741093012896 anchoring element; other site 741093012897 dimer interface [polypeptide binding]; other site 741093012898 ATP binding site [chemical binding]; other site 741093012899 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 741093012900 active site 741093012901 putative metal-binding site [ion binding]; other site 741093012902 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 741093012903 recF protein; Region: recf; TIGR00611 741093012904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093012905 Walker A/P-loop; other site 741093012906 ATP binding site [chemical binding]; other site 741093012907 Q-loop/lid; other site 741093012908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093012909 ABC transporter signature motif; other site 741093012910 Walker B; other site 741093012911 D-loop; other site 741093012912 H-loop/switch region; other site 741093012913 DNA polymerase III subunit beta; Validated; Region: PRK05643 741093012914 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 741093012915 putative DNA binding surface [nucleotide binding]; other site 741093012916 dimer interface [polypeptide binding]; other site 741093012917 beta-clamp/clamp loader binding surface; other site 741093012918 beta-clamp/translesion DNA polymerase binding surface; other site 741093012919 DnaA N-terminal domain; Region: DnaA_N; pfam11638 741093012920 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 741093012921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093012922 Walker A motif; other site 741093012923 ATP binding site [chemical binding]; other site 741093012924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 741093012925 Walker B motif; other site 741093012926 arginine finger; other site 741093012927 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 741093012928 DnaA box-binding interface [nucleotide binding]; other site 741093012929 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 741093012930 ribonuclease P; Reviewed; Region: rnpA; PRK01732 741093012931 membrane protein insertase; Provisional; Region: PRK01318 741093012932 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 741093012933 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 741093012934 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 741093012935 trmE is a tRNA modification GTPase; Region: trmE; cd04164 741093012936 G1 box; other site 741093012937 GTP/Mg2+ binding site [chemical binding]; other site 741093012938 Switch I region; other site 741093012939 G2 box; other site 741093012940 Switch II region; other site 741093012941 G3 box; other site 741093012942 G4 box; other site 741093012943 G5 box; other site 741093012944 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 741093012945 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 741093012946 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 741093012947 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 741093012948 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 741093012949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741093012950 catalytic residue [active] 741093012951 tryptophan permease TnaB; Provisional; Region: PRK09664 741093012952 aromatic amino acid transport protein; Region: araaP; TIGR00837 741093012953 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 741093012954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093012955 putative substrate translocation pore; other site 741093012956 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 741093012957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093012958 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 741093012959 substrate binding pocket [chemical binding]; other site 741093012960 dimerization interface [polypeptide binding]; other site 741093012961 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 741093012962 Predicted flavoprotein [General function prediction only]; Region: COG0431 741093012963 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741093012964 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741093012965 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 741093012966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093012967 active site 741093012968 motif I; other site 741093012969 motif II; other site 741093012970 Salmonella outer protein D; Region: SopD; cl14701 741093012971 transcriptional regulator PhoU; Provisional; Region: PRK11115 741093012972 PhoU domain; Region: PhoU; pfam01895 741093012973 PhoU domain; Region: PhoU; pfam01895 741093012974 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 741093012975 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 741093012976 Walker A/P-loop; other site 741093012977 ATP binding site [chemical binding]; other site 741093012978 Q-loop/lid; other site 741093012979 ABC transporter signature motif; other site 741093012980 Walker B; other site 741093012981 D-loop; other site 741093012982 H-loop/switch region; other site 741093012983 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 741093012984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093012985 dimer interface [polypeptide binding]; other site 741093012986 conserved gate region; other site 741093012987 putative PBP binding loops; other site 741093012988 ABC-ATPase subunit interface; other site 741093012989 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 741093012990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093012991 dimer interface [polypeptide binding]; other site 741093012992 conserved gate region; other site 741093012993 putative PBP binding loops; other site 741093012994 ABC-ATPase subunit interface; other site 741093012995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093012996 Fimbrial protein; Region: Fimbrial; cl01416 741093012997 Fimbrial protein; Region: Fimbrial; cl01416 741093012998 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741093012999 PapC N-terminal domain; Region: PapC_N; pfam13954 741093013000 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093013001 PapC C-terminal domain; Region: PapC_C; pfam13953 741093013002 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093013003 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093013004 fimbrial protein; Provisional; Region: lpfA; PRK15289 741093013005 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 741093013006 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 741093013007 glutaminase active site [active] 741093013008 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 741093013009 dimer interface [polypeptide binding]; other site 741093013010 active site 741093013011 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 741093013012 dimer interface [polypeptide binding]; other site 741093013013 active site 741093013014 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 741093013015 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 741093013016 Substrate binding site; other site 741093013017 Mg++ binding site; other site 741093013018 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 741093013019 active site 741093013020 substrate binding site [chemical binding]; other site 741093013021 CoA binding site [chemical binding]; other site 741093013022 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 741093013023 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 741093013024 gamma subunit interface [polypeptide binding]; other site 741093013025 epsilon subunit interface [polypeptide binding]; other site 741093013026 LBP interface [polypeptide binding]; other site 741093013027 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 741093013028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 741093013029 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 741093013030 alpha subunit interaction interface [polypeptide binding]; other site 741093013031 Walker A motif; other site 741093013032 ATP binding site [chemical binding]; other site 741093013033 Walker B motif; other site 741093013034 inhibitor binding site; inhibition site 741093013035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 741093013036 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 741093013037 core domain interface [polypeptide binding]; other site 741093013038 delta subunit interface [polypeptide binding]; other site 741093013039 epsilon subunit interface [polypeptide binding]; other site 741093013040 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 741093013041 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 741093013042 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 741093013043 beta subunit interaction interface [polypeptide binding]; other site 741093013044 Walker A motif; other site 741093013045 ATP binding site [chemical binding]; other site 741093013046 Walker B motif; other site 741093013047 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 741093013048 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 741093013049 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 741093013050 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 741093013051 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 741093013052 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 741093013053 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 741093013054 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 741093013055 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 741093013056 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 741093013057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093013058 S-adenosylmethionine binding site [chemical binding]; other site 741093013059 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 741093013060 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 741093013061 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 741093013062 FMN-binding protein MioC; Provisional; Region: PRK09004 741093013063 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 741093013064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093013065 putative DNA binding site [nucleotide binding]; other site 741093013066 putative Zn2+ binding site [ion binding]; other site 741093013067 AsnC family; Region: AsnC_trans_reg; pfam01037 741093013068 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 741093013069 dimer interface [polypeptide binding]; other site 741093013070 active site 741093013071 hypothetical protein; Provisional; Region: yieM; PRK10997 741093013072 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 741093013073 metal ion-dependent adhesion site (MIDAS); other site 741093013074 regulatory ATPase RavA; Provisional; Region: PRK13531 741093013075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093013076 Walker A motif; other site 741093013077 ATP binding site [chemical binding]; other site 741093013078 Walker B motif; other site 741093013079 arginine finger; other site 741093013080 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 741093013081 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 741093013082 potassium uptake protein; Region: kup; TIGR00794 741093013083 D-ribose pyranase; Provisional; Region: PRK11797 741093013084 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 741093013085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093013086 Walker A/P-loop; other site 741093013087 ATP binding site [chemical binding]; other site 741093013088 Q-loop/lid; other site 741093013089 ABC transporter signature motif; other site 741093013090 Walker B; other site 741093013091 D-loop; other site 741093013092 H-loop/switch region; other site 741093013093 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093013094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093013095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093013096 TM-ABC transporter signature motif; other site 741093013097 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 741093013098 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 741093013099 ligand binding site [chemical binding]; other site 741093013100 dimerization interface [polypeptide binding]; other site 741093013101 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 741093013102 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093013103 substrate binding site [chemical binding]; other site 741093013104 dimer interface [polypeptide binding]; other site 741093013105 ATP binding site [chemical binding]; other site 741093013106 transcriptional repressor RbsR; Provisional; Region: PRK10423 741093013107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093013108 DNA binding site [nucleotide binding] 741093013109 domain linker motif; other site 741093013110 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 741093013111 dimerization interface [polypeptide binding]; other site 741093013112 ligand binding site [chemical binding]; other site 741093013113 putative transporter; Provisional; Region: PRK10504 741093013114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093013115 putative substrate translocation pore; other site 741093013116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093013117 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741093013118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093013119 DNA-binding site [nucleotide binding]; DNA binding site 741093013120 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741093013121 transcriptional regulator HdfR; Provisional; Region: PRK03601 741093013122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093013123 LysR substrate binding domain; Region: LysR_substrate; pfam03466 741093013124 dimerization interface [polypeptide binding]; other site 741093013125 hypothetical protein; Provisional; Region: PRK11027 741093013126 putative ATP-dependent protease; Provisional; Region: PRK09862 741093013127 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 741093013128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093013129 Walker A motif; other site 741093013130 ATP binding site [chemical binding]; other site 741093013131 Walker B motif; other site 741093013132 arginine finger; other site 741093013133 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 741093013134 ilvG operon leader peptide; Provisional; Region: PRK10424 741093013135 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 741093013136 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741093013137 PYR/PP interface [polypeptide binding]; other site 741093013138 dimer interface [polypeptide binding]; other site 741093013139 TPP binding site [chemical binding]; other site 741093013140 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741093013141 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 741093013142 TPP-binding site [chemical binding]; other site 741093013143 dimer interface [polypeptide binding]; other site 741093013144 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 741093013145 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 741093013146 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 741093013147 homodimer interface [polypeptide binding]; other site 741093013148 substrate-cofactor binding pocket; other site 741093013149 catalytic residue [active] 741093013150 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 741093013151 threonine dehydratase; Reviewed; Region: PRK09224 741093013152 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 741093013153 tetramer interface [polypeptide binding]; other site 741093013154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093013155 catalytic residue [active] 741093013156 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 741093013157 putative Ile/Val binding site [chemical binding]; other site 741093013158 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 741093013159 putative Ile/Val binding site [chemical binding]; other site 741093013160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093013161 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 741093013162 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 741093013163 putative dimerization interface [polypeptide binding]; other site 741093013164 ketol-acid reductoisomerase; Validated; Region: PRK05225 741093013165 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 741093013166 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 741093013167 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 741093013168 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 741093013169 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 741093013170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 741093013171 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 741093013172 Part of AAA domain; Region: AAA_19; pfam13245 741093013173 Family description; Region: UvrD_C_2; pfam13538 741093013174 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 741093013175 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 741093013176 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 741093013177 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741093013178 ATP binding site [chemical binding]; other site 741093013179 Mg++ binding site [ion binding]; other site 741093013180 motif III; other site 741093013181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093013182 nucleotide binding region [chemical binding]; other site 741093013183 ATP-binding site [chemical binding]; other site 741093013184 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 741093013185 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 741093013186 catalytic residues [active] 741093013187 putative rho operon leader peptide; Provisional; Region: PRK09979 741093013188 transcription termination factor Rho; Provisional; Region: rho; PRK09376 741093013189 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 741093013190 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 741093013191 RNA binding site [nucleotide binding]; other site 741093013192 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 741093013193 multimer interface [polypeptide binding]; other site 741093013194 Walker A motif; other site 741093013195 ATP binding site [chemical binding]; other site 741093013196 Walker B motif; other site 741093013197 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 741093013198 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 741093013199 Mg++ binding site [ion binding]; other site 741093013200 putative catalytic motif [active] 741093013201 substrate binding site [chemical binding]; other site 741093013202 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 741093013203 Chain length determinant protein; Region: Wzz; pfam02706 741093013204 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 741093013205 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 741093013206 active site 741093013207 homodimer interface [polypeptide binding]; other site 741093013208 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 741093013209 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 741093013210 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 741093013211 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 741093013212 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 741093013213 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 741093013214 NAD binding site [chemical binding]; other site 741093013215 substrate binding site [chemical binding]; other site 741093013216 homodimer interface [polypeptide binding]; other site 741093013217 active site 741093013218 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 741093013219 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 741093013220 substrate binding site; other site 741093013221 tetramer interface; other site 741093013222 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 741093013223 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 741093013224 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 741093013225 inhibitor-cofactor binding pocket; inhibition site 741093013226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093013227 catalytic residue [active] 741093013228 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 741093013229 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 741093013230 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 741093013231 putative common antigen polymerase; Provisional; Region: PRK02975 741093013232 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 741093013233 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 741093013234 putative transport protein YifK; Provisional; Region: PRK10746 741093013235 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 741093013236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093013237 FeS/SAM binding site; other site 741093013238 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 741093013239 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 741093013240 Sulfatase; Region: Sulfatase; pfam00884 741093013241 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 741093013242 HemY protein N-terminus; Region: HemY_N; pfam07219 741093013243 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 741093013244 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 741093013245 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 741093013246 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 741093013247 active site 741093013248 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 741093013249 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 741093013250 domain interfaces; other site 741093013251 active site 741093013252 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 741093013253 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 741093013254 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 741093013255 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 741093013256 putative iron binding site [ion binding]; other site 741093013257 hypothetical protein; Provisional; Region: PRK09807 741093013258 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 741093013259 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 741093013260 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 741093013261 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 741093013262 hypothetical protein; Provisional; Region: PRK10963 741093013263 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 741093013264 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741093013265 active site 741093013266 DNA binding site [nucleotide binding] 741093013267 Int/Topo IB signature motif; other site 741093013268 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 741093013269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093013270 motif II; other site 741093013271 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 741093013272 Part of AAA domain; Region: AAA_19; pfam13245 741093013273 Family description; Region: UvrD_C_2; pfam13538 741093013274 Uncharacterized conserved protein [Function unknown]; Region: COG1912 741093013275 Predicted periplasmic protein [Function unknown]; Region: COG3698 741093013276 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 741093013277 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 741093013278 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 741093013279 Cl binding site [ion binding]; other site 741093013280 oligomer interface [polypeptide binding]; other site 741093013281 conserved hypothetical protein; Region: TIGR03034 741093013282 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 741093013283 EamA-like transporter family; Region: EamA; cl17759 741093013284 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 741093013285 CoenzymeA binding site [chemical binding]; other site 741093013286 subunit interaction site [polypeptide binding]; other site 741093013287 PHB binding site; other site 741093013288 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 741093013289 dimerization interface [polypeptide binding]; other site 741093013290 substrate binding site [chemical binding]; other site 741093013291 active site 741093013292 calcium binding site [ion binding]; other site 741093013293 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 741093013294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093013295 ATP binding site [chemical binding]; other site 741093013296 putative Mg++ binding site [ion binding]; other site 741093013297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093013298 nucleotide binding region [chemical binding]; other site 741093013299 ATP-binding site [chemical binding]; other site 741093013300 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 741093013301 Helicase and RNase D C-terminal; Region: HRDC; smart00341 741093013302 threonine efflux system; Provisional; Region: PRK10229 741093013303 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 741093013304 lysophospholipase L2; Provisional; Region: PRK10749 741093013305 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741093013306 putative hydrolase; Provisional; Region: PRK10976 741093013307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093013308 active site 741093013309 motif I; other site 741093013310 motif II; other site 741093013311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093013312 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 741093013313 EamA-like transporter family; Region: EamA; pfam00892 741093013314 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 741093013315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093013316 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 741093013317 putative dimerization interface [polypeptide binding]; other site 741093013318 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 741093013319 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 741093013320 THF binding site; other site 741093013321 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 741093013322 substrate binding site [chemical binding]; other site 741093013323 THF binding site; other site 741093013324 zinc-binding site [ion binding]; other site 741093013325 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 741093013326 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 741093013327 uridine phosphorylase; Provisional; Region: PRK11178 741093013328 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 741093013329 DNA recombination protein RmuC; Provisional; Region: PRK10361 741093013330 RmuC family; Region: RmuC; pfam02646 741093013331 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 741093013332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093013333 S-adenosylmethionine binding site [chemical binding]; other site 741093013334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 741093013335 SCP-2 sterol transfer family; Region: SCP2; pfam02036 741093013336 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 741093013337 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 741093013338 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 741093013339 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 741093013340 sec-independent translocase; Provisional; Region: PRK01770 741093013341 sec-independent translocase; Provisional; Region: tatB; PRK00404 741093013342 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 741093013343 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 741093013344 active site 741093013345 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 741093013346 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 741093013347 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 741093013348 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 741093013349 FMN reductase; Validated; Region: fre; PRK08051 741093013350 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 741093013351 FAD binding pocket [chemical binding]; other site 741093013352 FAD binding motif [chemical binding]; other site 741093013353 phosphate binding motif [ion binding]; other site 741093013354 beta-alpha-beta structure motif; other site 741093013355 NAD binding pocket [chemical binding]; other site 741093013356 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 741093013357 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 741093013358 dimer interface [polypeptide binding]; other site 741093013359 active site 741093013360 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 741093013361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741093013362 substrate binding site [chemical binding]; other site 741093013363 oxyanion hole (OAH) forming residues; other site 741093013364 trimer interface [polypeptide binding]; other site 741093013365 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 741093013366 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741093013367 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741093013368 proline dipeptidase; Provisional; Region: PRK13607 741093013369 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 741093013370 active site 741093013371 hypothetical protein; Provisional; Region: PRK11568 741093013372 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 741093013373 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 741093013374 potassium transporter; Provisional; Region: PRK10750 741093013375 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 741093013376 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 741093013377 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 741093013378 Walker A motif; other site 741093013379 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 741093013380 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 741093013381 GTP binding site; other site 741093013382 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 741093013383 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 741093013384 serine/threonine protein kinase; Provisional; Region: PRK11768 741093013385 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 741093013386 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 741093013387 catalytic residues [active] 741093013388 hinge region; other site 741093013389 alpha helical domain; other site 741093013390 hypothetical protein; Provisional; Region: PRK11367 741093013391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 741093013392 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 741093013393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 741093013394 putative acyl-acceptor binding pocket; other site 741093013395 DNA polymerase I; Provisional; Region: PRK05755 741093013396 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 741093013397 active site 741093013398 metal binding site 1 [ion binding]; metal-binding site 741093013399 putative 5' ssDNA interaction site; other site 741093013400 metal binding site 3; metal-binding site 741093013401 metal binding site 2 [ion binding]; metal-binding site 741093013402 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 741093013403 putative DNA binding site [nucleotide binding]; other site 741093013404 putative metal binding site [ion binding]; other site 741093013405 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 741093013406 active site 741093013407 catalytic site [active] 741093013408 substrate binding site [chemical binding]; other site 741093013409 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 741093013410 active site 741093013411 DNA binding site [nucleotide binding] 741093013412 catalytic site [active] 741093013413 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 741093013414 G1 box; other site 741093013415 GTP/Mg2+ binding site [chemical binding]; other site 741093013416 Switch I region; other site 741093013417 G2 box; other site 741093013418 G3 box; other site 741093013419 Switch II region; other site 741093013420 G4 box; other site 741093013421 G5 box; other site 741093013422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 741093013423 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 741093013424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093013425 FeS/SAM binding site; other site 741093013426 HemN C-terminal domain; Region: HemN_C; pfam06969 741093013427 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 741093013428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093013429 active site 741093013430 phosphorylation site [posttranslational modification] 741093013431 intermolecular recognition site; other site 741093013432 dimerization interface [polypeptide binding]; other site 741093013433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093013434 Walker A motif; other site 741093013435 ATP binding site [chemical binding]; other site 741093013436 Walker B motif; other site 741093013437 arginine finger; other site 741093013438 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741093013439 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 741093013440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741093013441 putative active site [active] 741093013442 heme pocket [chemical binding]; other site 741093013443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093013444 dimer interface [polypeptide binding]; other site 741093013445 phosphorylation site [posttranslational modification] 741093013446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093013447 ATP binding site [chemical binding]; other site 741093013448 Mg2+ binding site [ion binding]; other site 741093013449 G-X-G motif; other site 741093013450 glutamine synthetase; Provisional; Region: glnA; PRK09469 741093013451 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 741093013452 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 741093013453 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 741093013454 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 741093013455 G1 box; other site 741093013456 putative GEF interaction site [polypeptide binding]; other site 741093013457 GTP/Mg2+ binding site [chemical binding]; other site 741093013458 Switch I region; other site 741093013459 G2 box; other site 741093013460 G3 box; other site 741093013461 Switch II region; other site 741093013462 G4 box; other site 741093013463 G5 box; other site 741093013464 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 741093013465 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 741093013466 transcriptional regulator protein; Region: phnR; TIGR03337 741093013467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093013468 DNA-binding site [nucleotide binding]; DNA binding site 741093013469 UTRA domain; Region: UTRA; pfam07702 741093013470 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 741093013471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093013472 putative substrate translocation pore; other site 741093013473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093013474 outer membrane porin L; Provisional; Region: ompL; PRK09980 741093013475 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 741093013476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093013477 putative substrate translocation pore; other site 741093013478 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741093013479 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 741093013480 alpha-glucosidase; Provisional; Region: PRK10426 741093013481 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 741093013482 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 741093013483 putative active site [active] 741093013484 putative catalytic site [active] 741093013485 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 741093013486 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 741093013487 active site 741093013488 catalytic residues [active] 741093013489 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 741093013490 dimerization interface [polypeptide binding]; other site 741093013491 putative active cleft [active] 741093013492 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 741093013493 catalytic residue [active] 741093013494 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 741093013495 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741093013496 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093013497 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 741093013498 substrate binding site [chemical binding]; other site 741093013499 ATP binding site [chemical binding]; other site 741093013500 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741093013501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093013502 putative DNA binding site [nucleotide binding]; other site 741093013503 putative Zn2+ binding site [ion binding]; other site 741093013504 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093013505 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 741093013506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093013507 motif II; other site 741093013508 hypothetical protein; Reviewed; Region: PRK01637 741093013509 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 741093013510 putative active site [active] 741093013511 dimerization interface [polypeptide binding]; other site 741093013512 putative tRNAtyr binding site [nucleotide binding]; other site 741093013513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093013514 Coenzyme A binding pocket [chemical binding]; other site 741093013515 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 741093013516 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 741093013517 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 741093013518 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 741093013519 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 741093013520 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 741093013521 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 741093013522 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 741093013523 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 741093013524 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 741093013525 putative frv operon regulatory protein; Provisional; Region: PRK09863 741093013526 HTH domain; Region: HTH_11; pfam08279 741093013527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093013528 active site 741093013529 phosphorylation site [posttranslational modification] 741093013530 putative peptidase; Provisional; Region: PRK09864 741093013531 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 741093013532 oligomer interface [polypeptide binding]; other site 741093013533 active site 741093013534 metal binding site [ion binding]; metal-binding site 741093013535 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 741093013536 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741093013537 active site 741093013538 P-loop; other site 741093013539 phosphorylation site [posttranslational modification] 741093013540 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 741093013541 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093013542 active site 741093013543 phosphorylation site [posttranslational modification] 741093013544 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 741093013545 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 741093013546 intersubunit interface [polypeptide binding]; other site 741093013547 active site 741093013548 Zn2+ binding site [ion binding]; other site 741093013549 L-rhamnose isomerase; Provisional; Region: PRK01076 741093013550 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 741093013551 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 741093013552 N- and C-terminal domain interface [polypeptide binding]; other site 741093013553 active site 741093013554 putative catalytic site [active] 741093013555 metal binding site [ion binding]; metal-binding site 741093013556 ATP binding site [chemical binding]; other site 741093013557 rhamnulokinase; Provisional; Region: rhaB; PRK10640 741093013558 carbohydrate binding site [chemical binding]; other site 741093013559 transcriptional activator RhaS; Provisional; Region: PRK13503 741093013560 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741093013561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093013562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093013563 transcriptional activator RhaR; Provisional; Region: PRK13500 741093013564 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741093013565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093013566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093013567 superoxide dismutase; Provisional; Region: PRK10925 741093013568 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 741093013569 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 741093013570 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 741093013571 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 741093013572 MOSC domain; Region: MOSC; pfam03473 741093013573 3-alpha domain; Region: 3-alpha; pfam03475 741093013574 two-component sensor protein; Provisional; Region: cpxA; PRK09470 741093013575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093013576 dimerization interface [polypeptide binding]; other site 741093013577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093013578 dimer interface [polypeptide binding]; other site 741093013579 phosphorylation site [posttranslational modification] 741093013580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093013581 ATP binding site [chemical binding]; other site 741093013582 Mg2+ binding site [ion binding]; other site 741093013583 G-X-G motif; other site 741093013584 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 741093013585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093013586 active site 741093013587 intermolecular recognition site; other site 741093013588 dimerization interface [polypeptide binding]; other site 741093013589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093013590 DNA binding site [nucleotide binding] 741093013591 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 741093013592 dimer interface [polypeptide binding]; other site 741093013593 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 741093013594 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 741093013595 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 741093013596 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 741093013597 active site 741093013598 ADP/pyrophosphate binding site [chemical binding]; other site 741093013599 dimerization interface [polypeptide binding]; other site 741093013600 allosteric effector site; other site 741093013601 fructose-1,6-bisphosphate binding site; other site 741093013602 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741093013603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741093013604 substrate binding pocket [chemical binding]; other site 741093013605 membrane-bound complex binding site; other site 741093013606 hinge residues; other site 741093013607 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 741093013608 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 741093013609 triosephosphate isomerase; Provisional; Region: PRK14567 741093013610 substrate binding site [chemical binding]; other site 741093013611 dimer interface [polypeptide binding]; other site 741093013612 catalytic triad [active] 741093013613 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 741093013614 Predicted membrane protein [Function unknown]; Region: COG3152 741093013615 hypothetical protein; Provisional; Region: PRK09981 741093013616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741093013617 Ligand Binding Site [chemical binding]; other site 741093013618 ferredoxin-NADP reductase; Provisional; Region: PRK10926 741093013619 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 741093013620 FAD binding pocket [chemical binding]; other site 741093013621 FAD binding motif [chemical binding]; other site 741093013622 phosphate binding motif [ion binding]; other site 741093013623 beta-alpha-beta structure motif; other site 741093013624 NAD binding pocket [chemical binding]; other site 741093013625 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 741093013626 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 741093013627 putative active site [active] 741093013628 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 741093013629 amphipathic channel; other site 741093013630 Asn-Pro-Ala signature motifs; other site 741093013631 septal ring assembly protein ZapB; Provisional; Region: PRK15422 741093013632 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 741093013633 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 741093013634 UbiA prenyltransferase family; Region: UbiA; pfam01040 741093013635 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 741093013636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093013637 Walker A motif; other site 741093013638 ATP binding site [chemical binding]; other site 741093013639 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 741093013640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 741093013641 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 741093013642 active site 741093013643 HslU subunit interaction site [polypeptide binding]; other site 741093013644 essential cell division protein FtsN; Provisional; Region: PRK10927 741093013645 cell division protein FtsN; Provisional; Region: PRK12757 741093013646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093013647 DNA binding site [nucleotide binding] 741093013648 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 741093013649 domain linker motif; other site 741093013650 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 741093013651 dimerization interface [polypeptide binding]; other site 741093013652 ligand binding site [chemical binding]; other site 741093013653 primosome assembly protein PriA; Validated; Region: PRK05580 741093013654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093013655 ATP binding site [chemical binding]; other site 741093013656 putative Mg++ binding site [ion binding]; other site 741093013657 helicase superfamily c-terminal domain; Region: HELICc; smart00490 741093013658 ATP-binding site [chemical binding]; other site 741093013659 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 741093013660 PAAR motif; Region: PAAR_motif; cl15808 741093013661 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093013662 RHS Repeat; Region: RHS_repeat; pfam05593 741093013663 RHS Repeat; Region: RHS_repeat; pfam05593 741093013664 RHS Repeat; Region: RHS_repeat; pfam05593 741093013665 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 741093013666 RHS Repeat; Region: RHS_repeat; pfam05593 741093013667 RHS Repeat; Region: RHS_repeat; pfam05593 741093013668 RHS protein; Region: RHS; pfam03527 741093013669 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741093013670 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 741093013671 hypothetical protein; Provisional; Region: PRK10030 741093013672 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 741093013673 dimerization interface [polypeptide binding]; other site 741093013674 DNA binding site [nucleotide binding] 741093013675 corepressor binding sites; other site 741093013676 cystathionine gamma-synthase; Provisional; Region: PRK08045 741093013677 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 741093013678 homodimer interface [polypeptide binding]; other site 741093013679 substrate-cofactor binding pocket; other site 741093013680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093013681 catalytic residue [active] 741093013682 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 741093013683 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 741093013684 putative catalytic residues [active] 741093013685 putative nucleotide binding site [chemical binding]; other site 741093013686 putative aspartate binding site [chemical binding]; other site 741093013687 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 741093013688 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 741093013689 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 741093013690 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 741093013691 FAD binding site [chemical binding]; other site 741093013692 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 741093013693 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 741093013694 heme binding site [chemical binding]; other site 741093013695 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 741093013696 EamA-like transporter family; Region: EamA; pfam00892 741093013697 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 741093013698 EamA-like transporter family; Region: EamA; pfam00892 741093013699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 741093013700 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 741093013701 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 741093013702 dimer interface [polypeptide binding]; other site 741093013703 active site 741093013704 metal binding site [ion binding]; metal-binding site 741093013705 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 741093013706 active site 741093013707 intersubunit interactions; other site 741093013708 catalytic residue [active] 741093013709 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741093013710 dimerization domain swap beta strand [polypeptide binding]; other site 741093013711 regulatory protein interface [polypeptide binding]; other site 741093013712 active site 741093013713 regulatory phosphorylation site [posttranslational modification]; other site 741093013714 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741093013715 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 741093013716 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741093013717 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741093013718 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093013719 active site 741093013720 phosphorylation site [posttranslational modification] 741093013721 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741093013722 active site 741093013723 P-loop; other site 741093013724 phosphorylation site [posttranslational modification] 741093013725 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 741093013726 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 741093013727 dimer interface [polypeptide binding]; other site 741093013728 active site 741093013729 glycine loop; other site 741093013730 pyruvate formate lyase II activase; Provisional; Region: PRK10076 741093013731 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741093013732 active site 741093013733 P-loop; other site 741093013734 phosphorylation site [posttranslational modification] 741093013735 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093013736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093013737 hypothetical protein; Provisional; Region: PRK10649 741093013738 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741093013739 Sulfatase; Region: Sulfatase; pfam00884 741093013740 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 741093013741 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 741093013742 acetylornithine deacetylase; Provisional; Region: PRK05111 741093013743 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 741093013744 metal binding site [ion binding]; metal-binding site 741093013745 putative dimer interface [polypeptide binding]; other site 741093013746 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 741093013747 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741093013748 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 741093013749 nucleotide binding site [chemical binding]; other site 741093013750 N-acetyl-L-glutamate binding site [chemical binding]; other site 741093013751 argininosuccinate lyase; Provisional; Region: PRK04833 741093013752 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 741093013753 active sites [active] 741093013754 tetramer interface [polypeptide binding]; other site 741093013755 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 741093013756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741093013757 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 741093013758 dimerization interface [polypeptide binding]; other site 741093013759 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 741093013760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741093013761 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741093013762 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741093013763 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 741093013764 metal binding site [ion binding]; metal-binding site 741093013765 putative dimer interface [polypeptide binding]; other site 741093013766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093013767 metabolite-proton symporter; Region: 2A0106; TIGR00883 741093013768 putative substrate translocation pore; other site 741093013769 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 741093013770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093013771 hypothetical protein; Provisional; Region: PRK11056 741093013772 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 741093013773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093013774 S-adenosylmethionine binding site [chemical binding]; other site 741093013775 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 741093013776 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741093013777 N-terminal plug; other site 741093013778 ligand-binding site [chemical binding]; other site 741093013779 glutamate racemase; Provisional; Region: PRK00865 741093013780 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 741093013781 FAD binding domain; Region: FAD_binding_4; pfam01565 741093013782 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 741093013783 Biotin operon repressor [Transcription]; Region: BirA; COG1654 741093013784 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 741093013785 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 741093013786 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 741093013787 pantothenate kinase; Provisional; Region: PRK05439 741093013788 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 741093013789 ATP-binding site [chemical binding]; other site 741093013790 CoA-binding site [chemical binding]; other site 741093013791 Mg2+-binding site [ion binding]; other site 741093013792 elongation factor Tu; Reviewed; Region: PRK00049 741093013793 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 741093013794 G1 box; other site 741093013795 GEF interaction site [polypeptide binding]; other site 741093013796 GTP/Mg2+ binding site [chemical binding]; other site 741093013797 Switch I region; other site 741093013798 G2 box; other site 741093013799 G3 box; other site 741093013800 Switch II region; other site 741093013801 G4 box; other site 741093013802 G5 box; other site 741093013803 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 741093013804 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 741093013805 Antibiotic Binding Site [chemical binding]; other site 741093013806 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 741093013807 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 741093013808 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 741093013809 putative homodimer interface [polypeptide binding]; other site 741093013810 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 741093013811 heterodimer interface [polypeptide binding]; other site 741093013812 homodimer interface [polypeptide binding]; other site 741093013813 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 741093013814 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 741093013815 23S rRNA interface [nucleotide binding]; other site 741093013816 L7/L12 interface [polypeptide binding]; other site 741093013817 putative thiostrepton binding site; other site 741093013818 L25 interface [polypeptide binding]; other site 741093013819 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 741093013820 mRNA/rRNA interface [nucleotide binding]; other site 741093013821 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 741093013822 23S rRNA interface [nucleotide binding]; other site 741093013823 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 741093013824 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 741093013825 core dimer interface [polypeptide binding]; other site 741093013826 peripheral dimer interface [polypeptide binding]; other site 741093013827 L10 interface [polypeptide binding]; other site 741093013828 L11 interface [polypeptide binding]; other site 741093013829 putative EF-Tu interaction site [polypeptide binding]; other site 741093013830 putative EF-G interaction site [polypeptide binding]; other site 741093013831 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 741093013832 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 741093013833 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 741093013834 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 741093013835 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 741093013836 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 741093013837 RPB3 interaction site [polypeptide binding]; other site 741093013838 RPB1 interaction site [polypeptide binding]; other site 741093013839 RPB11 interaction site [polypeptide binding]; other site 741093013840 RPB10 interaction site [polypeptide binding]; other site 741093013841 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 741093013842 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 741093013843 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 741093013844 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 741093013845 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 741093013846 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 741093013847 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 741093013848 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 741093013849 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 741093013850 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 741093013851 DNA binding site [nucleotide binding] 741093013852 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 741093013853 stationary phase growth adaptation protein; Provisional; Region: PRK09717 741093013854 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 741093013855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093013856 FeS/SAM binding site; other site 741093013857 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 741093013858 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 741093013859 ThiS interaction site; other site 741093013860 putative active site [active] 741093013861 tetramer interface [polypeptide binding]; other site 741093013862 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 741093013863 thiS-thiF/thiG interaction site; other site 741093013864 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 741093013865 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 741093013866 ATP binding site [chemical binding]; other site 741093013867 substrate interface [chemical binding]; other site 741093013868 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 741093013869 thiamine phosphate binding site [chemical binding]; other site 741093013870 active site 741093013871 pyrophosphate binding site [ion binding]; other site 741093013872 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 741093013873 ThiC-associated domain; Region: ThiC-associated; pfam13667 741093013874 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 741093013875 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 741093013876 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 741093013877 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 741093013878 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 741093013879 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 741093013880 putative NADH binding site [chemical binding]; other site 741093013881 putative active site [active] 741093013882 nudix motif; other site 741093013883 putative metal binding site [ion binding]; other site 741093013884 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 741093013885 substrate binding site [chemical binding]; other site 741093013886 active site 741093013887 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 741093013888 Active_site [active] 741093013889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 741093013890 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741093013891 IHF dimer interface [polypeptide binding]; other site 741093013892 IHF - DNA interface [nucleotide binding]; other site 741093013893 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 741093013894 zinc resistance protein; Provisional; Region: zraP; PRK11546 741093013895 dimer interface [polypeptide binding]; other site 741093013896 sensor protein ZraS; Provisional; Region: PRK10364 741093013897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093013898 dimer interface [polypeptide binding]; other site 741093013899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093013900 ATP binding site [chemical binding]; other site 741093013901 Mg2+ binding site [ion binding]; other site 741093013902 G-X-G motif; other site 741093013903 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 741093013904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093013905 active site 741093013906 phosphorylation site [posttranslational modification] 741093013907 intermolecular recognition site; other site 741093013908 dimerization interface [polypeptide binding]; other site 741093013909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093013910 Walker A motif; other site 741093013911 ATP binding site [chemical binding]; other site 741093013912 Walker B motif; other site 741093013913 arginine finger; other site 741093013914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741093013915 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 741093013916 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 741093013917 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 741093013918 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 741093013919 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 741093013920 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 741093013921 purine monophosphate binding site [chemical binding]; other site 741093013922 dimer interface [polypeptide binding]; other site 741093013923 putative catalytic residues [active] 741093013924 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 741093013925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741093013926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093013927 Coenzyme A binding pocket [chemical binding]; other site 741093013928 homoserine O-succinyltransferase; Provisional; Region: PRK05368 741093013929 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 741093013930 proposed active site lysine [active] 741093013931 conserved cys residue [active] 741093013932 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 741093013933 malate synthase A; Region: malate_syn_A; TIGR01344 741093013934 active site 741093013935 isocitrate lyase; Provisional; Region: PRK15063 741093013936 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 741093013937 tetramer interface [polypeptide binding]; other site 741093013938 active site 741093013939 Mg2+/Mn2+ binding site [ion binding]; other site 741093013940 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 741093013941 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 741093013942 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 741093013943 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 741093013944 transcriptional repressor IclR; Provisional; Region: PRK11569 741093013945 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 741093013946 Bacterial transcriptional regulator; Region: IclR; pfam01614 741093013947 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 741093013948 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 741093013949 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 741093013950 substrate binding pocket [chemical binding]; other site 741093013951 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 741093013952 B12 binding site [chemical binding]; other site 741093013953 cobalt ligand [ion binding]; other site 741093013954 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 741093013955 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 741093013956 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 741093013957 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 741093013958 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 741093013959 active site pocket [active] 741093013960 oxyanion hole [active] 741093013961 catalytic triad [active] 741093013962 active site nucleophile [active] 741093013963 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 741093013964 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 741093013965 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093013966 putative NAD(P) binding site [chemical binding]; other site 741093013967 catalytic Zn binding site [ion binding]; other site 741093013968 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 741093013969 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 741093013970 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 741093013971 active site 741093013972 phosphorylation site [posttranslational modification] 741093013973 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 741093013974 active pocket/dimerization site; other site 741093013975 active site 741093013976 phosphorylation site [posttranslational modification] 741093013977 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 741093013978 classical (c) SDRs; Region: SDR_c; cd05233 741093013979 NAD(P) binding site [chemical binding]; other site 741093013980 active site 741093013981 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 741093013982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741093013983 putative DNA binding site [nucleotide binding]; other site 741093013984 putative Zn2+ binding site [ion binding]; other site 741093013985 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 741093013986 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 741093013987 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741093013988 RNA binding surface [nucleotide binding]; other site 741093013989 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 741093013990 probable active site [active] 741093013991 hypothetical protein; Provisional; Region: PRK10515 741093013992 aspartate kinase III; Validated; Region: PRK09084 741093013993 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 741093013994 nucleotide binding site [chemical binding]; other site 741093013995 substrate binding site [chemical binding]; other site 741093013996 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 741093013997 lysine allosteric regulatory site; other site 741093013998 dimer interface [polypeptide binding]; other site 741093013999 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 741093014000 dimer interface [polypeptide binding]; other site 741093014001 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 741093014002 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 741093014003 active site 741093014004 dimer interface [polypeptide binding]; other site 741093014005 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 741093014006 dimer interface [polypeptide binding]; other site 741093014007 active site 741093014008 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 741093014009 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 741093014010 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 741093014011 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 741093014012 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 741093014013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014014 putative substrate translocation pore; other site 741093014015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014016 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741093014017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093014018 dimer interface [polypeptide binding]; other site 741093014019 conserved gate region; other site 741093014020 putative PBP binding loops; other site 741093014021 ABC-ATPase subunit interface; other site 741093014022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093014023 dimer interface [polypeptide binding]; other site 741093014024 conserved gate region; other site 741093014025 putative PBP binding loops; other site 741093014026 ABC-ATPase subunit interface; other site 741093014027 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 741093014028 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 741093014029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741093014030 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 741093014031 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741093014032 Walker A/P-loop; other site 741093014033 ATP binding site [chemical binding]; other site 741093014034 Q-loop/lid; other site 741093014035 ABC transporter signature motif; other site 741093014036 Walker B; other site 741093014037 D-loop; other site 741093014038 H-loop/switch region; other site 741093014039 TOBE domain; Region: TOBE_2; pfam08402 741093014040 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 741093014041 trimer interface; other site 741093014042 sugar binding site [chemical binding]; other site 741093014043 maltose regulon periplasmic protein; Provisional; Region: PRK10564 741093014044 hypothetical protein; Validated; Region: PRK09718 741093014045 SopA-like central domain; Region: SopA; pfam13981 741093014046 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 741093014047 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 741093014048 UbiA prenyltransferase family; Region: UbiA; pfam01040 741093014049 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 741093014050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 741093014051 putative acyl-acceptor binding pocket; other site 741093014052 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 741093014053 LexA repressor; Validated; Region: PRK00215 741093014054 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 741093014055 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741093014056 Catalytic site [active] 741093014057 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 741093014058 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 741093014059 hypothetical protein; Provisional; Region: PRK10428 741093014060 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 741093014061 metal binding site 2 [ion binding]; metal-binding site 741093014062 putative DNA binding helix; other site 741093014063 metal binding site 1 [ion binding]; metal-binding site 741093014064 dimer interface [polypeptide binding]; other site 741093014065 structural Zn2+ binding site [ion binding]; other site 741093014066 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 741093014067 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 741093014068 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 741093014069 FMN binding site [chemical binding]; other site 741093014070 active site 741093014071 catalytic residues [active] 741093014072 substrate binding site [chemical binding]; other site 741093014073 phage shock protein G; Reviewed; Region: pspG; PRK09459 741093014074 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 741093014075 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 741093014076 NADP binding site [chemical binding]; other site 741093014077 dimer interface [polypeptide binding]; other site 741093014078 replicative DNA helicase; Provisional; Region: PRK08006 741093014079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 741093014080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 741093014081 Walker A motif; other site 741093014082 ATP binding site [chemical binding]; other site 741093014083 Walker B motif; other site 741093014084 DNA binding loops [nucleotide binding] 741093014085 alanine racemase; Reviewed; Region: alr; PRK00053 741093014086 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 741093014087 active site 741093014088 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741093014089 substrate binding site [chemical binding]; other site 741093014090 catalytic residues [active] 741093014091 dimer interface [polypeptide binding]; other site 741093014092 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 741093014093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093014094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093014095 homodimer interface [polypeptide binding]; other site 741093014096 catalytic residue [active] 741093014097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093014098 active site 741093014099 motif I; other site 741093014100 motif II; other site 741093014101 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 741093014102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 741093014103 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 741093014104 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 741093014105 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 741093014106 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 741093014107 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 741093014108 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 741093014109 dimer interface [polypeptide binding]; other site 741093014110 ssDNA binding site [nucleotide binding]; other site 741093014111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093014112 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 741093014113 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 741093014114 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741093014115 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741093014116 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 741093014117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093014118 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 741093014119 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 741093014120 DNA binding residues [nucleotide binding] 741093014121 dimer interface [polypeptide binding]; other site 741093014122 [2Fe-2S] cluster binding site [ion binding]; other site 741093014123 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741093014124 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 741093014125 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 741093014126 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 741093014127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014128 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014129 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 741093014130 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 741093014131 Na binding site [ion binding]; other site 741093014132 Predicted membrane protein [Function unknown]; Region: COG3162 741093014133 acetyl-CoA synthetase; Provisional; Region: PRK00174 741093014134 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 741093014135 active site 741093014136 CoA binding site [chemical binding]; other site 741093014137 acyl-activating enzyme (AAE) consensus motif; other site 741093014138 AMP binding site [chemical binding]; other site 741093014139 acetate binding site [chemical binding]; other site 741093014140 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 741093014141 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 741093014142 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 741093014143 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 741093014144 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 741093014145 heme lyase subunit NrfE; Provisional; Region: PRK10369 741093014146 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 741093014147 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 741093014148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741093014149 binding surface 741093014150 TPR motif; other site 741093014151 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 741093014152 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741093014153 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741093014154 Sel1-like repeats; Region: SEL1; smart00671 741093014155 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 741093014156 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 741093014157 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741093014158 multidrug resistance protein MdtN; Provisional; Region: PRK10476 741093014159 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741093014160 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093014161 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 741093014162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 741093014163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 741093014164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093014165 active site 741093014166 phosphorylation site [posttranslational modification] 741093014167 intermolecular recognition site; other site 741093014168 dimerization interface [polypeptide binding]; other site 741093014169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093014170 DNA binding site [nucleotide binding] 741093014171 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 741093014172 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741093014173 substrate binding site [chemical binding]; other site 741093014174 ATP binding site [chemical binding]; other site 741093014175 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 741093014176 intersubunit interface [polypeptide binding]; other site 741093014177 active site 741093014178 zinc binding site [ion binding]; other site 741093014179 Na+ binding site [ion binding]; other site 741093014180 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 741093014181 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 741093014182 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741093014183 putative ligand binding site [chemical binding]; other site 741093014184 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093014185 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093014186 TM-ABC transporter signature motif; other site 741093014187 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741093014188 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093014189 Walker A/P-loop; other site 741093014190 ATP binding site [chemical binding]; other site 741093014191 Q-loop/lid; other site 741093014192 ABC transporter signature motif; other site 741093014193 Walker B; other site 741093014194 D-loop; other site 741093014195 H-loop/switch region; other site 741093014196 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093014197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 741093014198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093014199 dimerization interface [polypeptide binding]; other site 741093014200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093014201 dimer interface [polypeptide binding]; other site 741093014202 phosphorylation site [posttranslational modification] 741093014203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093014204 ATP binding site [chemical binding]; other site 741093014205 Mg2+ binding site [ion binding]; other site 741093014206 G-X-G motif; other site 741093014207 Response regulator receiver domain; Region: Response_reg; pfam00072 741093014208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093014209 active site 741093014210 phosphorylation site [posttranslational modification] 741093014211 intermolecular recognition site; other site 741093014212 dimerization interface [polypeptide binding]; other site 741093014213 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 741093014214 putative hydrolase; Provisional; Region: PRK02113 741093014215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093014216 Coenzyme A binding pocket [chemical binding]; other site 741093014217 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 741093014218 AAA domain; Region: AAA_18; pfam13238 741093014219 active site 741093014220 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 741093014221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741093014222 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 741093014223 active site 741093014224 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 741093014225 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741093014226 Walker A/P-loop; other site 741093014227 ATP binding site [chemical binding]; other site 741093014228 Q-loop/lid; other site 741093014229 ABC transporter signature motif; other site 741093014230 Walker B; other site 741093014231 D-loop; other site 741093014232 H-loop/switch region; other site 741093014233 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 741093014234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741093014235 Walker A/P-loop; other site 741093014236 ATP binding site [chemical binding]; other site 741093014237 Q-loop/lid; other site 741093014238 ABC transporter signature motif; other site 741093014239 Walker B; other site 741093014240 D-loop; other site 741093014241 H-loop/switch region; other site 741093014242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741093014243 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 741093014244 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 741093014245 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 741093014246 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 741093014247 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 741093014248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093014249 DNA-binding site [nucleotide binding]; DNA binding site 741093014250 UTRA domain; Region: UTRA; pfam07702 741093014251 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 741093014252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741093014253 dimer interface [polypeptide binding]; other site 741093014254 conserved gate region; other site 741093014255 putative PBP binding loops; other site 741093014256 ABC-ATPase subunit interface; other site 741093014257 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 741093014258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 741093014259 substrate binding pocket [chemical binding]; other site 741093014260 membrane-bound complex binding site; other site 741093014261 hinge residues; other site 741093014262 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 741093014263 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 741093014264 Walker A/P-loop; other site 741093014265 ATP binding site [chemical binding]; other site 741093014266 Q-loop/lid; other site 741093014267 ABC transporter signature motif; other site 741093014268 Walker B; other site 741093014269 D-loop; other site 741093014270 H-loop/switch region; other site 741093014271 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 741093014272 dimer interface [polypeptide binding]; other site 741093014273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741093014274 hypothetical protein; Provisional; Region: PRK10220 741093014275 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 741093014276 PhnA protein; Region: PhnA; pfam03831 741093014277 hypothetical protein; Provisional; Region: PRK09866 741093014278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 741093014279 G1 box; other site 741093014280 GTP/Mg2+ binding site [chemical binding]; other site 741093014281 G2 box; other site 741093014282 Switch I region; other site 741093014283 G3 box; other site 741093014284 Switch II region; other site 741093014285 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 741093014286 G2 box; other site 741093014287 Switch I region; other site 741093014288 G3 box; other site 741093014289 Switch II region; other site 741093014290 G4 box; other site 741093014291 G5 box; other site 741093014292 YjcZ-like protein; Region: YjcZ; pfam13990 741093014293 proline/glycine betaine transporter; Provisional; Region: PRK10642 741093014294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014295 putative substrate translocation pore; other site 741093014296 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 741093014297 sensor protein BasS/PmrB; Provisional; Region: PRK10755 741093014298 HAMP domain; Region: HAMP; pfam00672 741093014299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093014300 dimer interface [polypeptide binding]; other site 741093014301 phosphorylation site [posttranslational modification] 741093014302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093014303 ATP binding site [chemical binding]; other site 741093014304 Mg2+ binding site [ion binding]; other site 741093014305 G-X-G motif; other site 741093014306 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 741093014307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093014308 active site 741093014309 phosphorylation site [posttranslational modification] 741093014310 intermolecular recognition site; other site 741093014311 dimerization interface [polypeptide binding]; other site 741093014312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093014313 DNA binding site [nucleotide binding] 741093014314 putative metal dependent hydrolase; Provisional; Region: PRK11598 741093014315 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741093014316 Sulfatase; Region: Sulfatase; pfam00884 741093014317 arginine:agmatin antiporter; Provisional; Region: PRK10644 741093014318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741093014319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093014320 arginine decarboxylase; Provisional; Region: PRK15029 741093014321 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741093014322 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741093014323 homodimer interface [polypeptide binding]; other site 741093014324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093014325 catalytic residue [active] 741093014326 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741093014327 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 741093014328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093014329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093014330 alpha-galactosidase; Provisional; Region: PRK15076 741093014331 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 741093014332 NAD binding site [chemical binding]; other site 741093014333 sugar binding site [chemical binding]; other site 741093014334 divalent metal binding site [ion binding]; other site 741093014335 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093014336 dimer interface [polypeptide binding]; other site 741093014337 melibiose:sodium symporter; Provisional; Region: PRK10429 741093014338 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 741093014339 hypothetical protein; Provisional; Region: PRK09867 741093014340 fumarate hydratase; Provisional; Region: PRK15389 741093014341 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 741093014342 Fumarase C-terminus; Region: Fumerase_C; pfam05683 741093014343 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 741093014344 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 741093014345 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 741093014346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093014347 active site 741093014348 phosphorylation site [posttranslational modification] 741093014349 intermolecular recognition site; other site 741093014350 dimerization interface [polypeptide binding]; other site 741093014351 Transcriptional regulator; Region: CitT; pfam12431 741093014352 sensory histidine kinase DcuS; Provisional; Region: PRK11086 741093014353 PAS domain; Region: PAS; smart00091 741093014354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093014355 ATP binding site [chemical binding]; other site 741093014356 Mg2+ binding site [ion binding]; other site 741093014357 G-X-G motif; other site 741093014358 Uncharacterized conserved protein [Function unknown]; Region: COG3592 741093014359 Predicted acetyltransferase [General function prediction only]; Region: COG2388 741093014360 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 741093014361 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 741093014362 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 741093014363 dimer interface [polypeptide binding]; other site 741093014364 putative anticodon binding site; other site 741093014365 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 741093014366 motif 1; other site 741093014367 active site 741093014368 motif 2; other site 741093014369 motif 3; other site 741093014370 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 741093014371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014372 putative substrate translocation pore; other site 741093014373 POT family; Region: PTR2; pfam00854 741093014374 lysine decarboxylase CadA; Provisional; Region: PRK15400 741093014375 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741093014376 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741093014377 homodimer interface [polypeptide binding]; other site 741093014378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093014379 catalytic residue [active] 741093014380 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741093014381 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 741093014382 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 741093014383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093014384 DNA binding site [nucleotide binding] 741093014385 putative transcriptional regulator; Provisional; Region: PRK11640 741093014386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093014387 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 741093014388 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 741093014389 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 741093014390 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 741093014391 DsbD alpha interface [polypeptide binding]; other site 741093014392 catalytic residues [active] 741093014393 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 741093014394 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 741093014395 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 741093014396 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 741093014397 Aspartase; Region: Aspartase; cd01357 741093014398 active sites [active] 741093014399 tetramer interface [polypeptide binding]; other site 741093014400 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 741093014401 putative transporter; Provisional; Region: PRK11021 741093014402 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 741093014403 oligomerisation interface [polypeptide binding]; other site 741093014404 mobile loop; other site 741093014405 roof hairpin; other site 741093014406 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 741093014407 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 741093014408 ring oligomerisation interface [polypeptide binding]; other site 741093014409 ATP/Mg binding site [chemical binding]; other site 741093014410 stacking interactions; other site 741093014411 hinge regions; other site 741093014412 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 741093014413 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 741093014414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093014415 FeS/SAM binding site; other site 741093014416 elongation factor P; Validated; Region: PRK00529 741093014417 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 741093014418 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 741093014419 RNA binding site [nucleotide binding]; other site 741093014420 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 741093014421 RNA binding site [nucleotide binding]; other site 741093014422 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 741093014423 multidrug efflux system protein; Provisional; Region: PRK11431 741093014424 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 741093014425 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 741093014426 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 741093014427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741093014428 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 741093014429 Iron-sulfur protein interface; other site 741093014430 proximal quinone binding site [chemical binding]; other site 741093014431 C-subunit interface; other site 741093014432 distal quinone binding site; other site 741093014433 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 741093014434 D-subunit interface [polypeptide binding]; other site 741093014435 Iron-sulfur protein interface; other site 741093014436 proximal quinone binding site [chemical binding]; other site 741093014437 distal quinone binding site [chemical binding]; other site 741093014438 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 741093014439 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 741093014440 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 741093014441 L-aspartate oxidase; Provisional; Region: PRK06175 741093014442 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 741093014443 poxB regulator PoxA; Provisional; Region: PRK09350 741093014444 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 741093014445 motif 1; other site 741093014446 dimer interface [polypeptide binding]; other site 741093014447 active site 741093014448 motif 2; other site 741093014449 motif 3; other site 741093014450 inner membrane transporter YjeM; Provisional; Region: PRK15238 741093014451 putative mechanosensitive channel protein; Provisional; Region: PRK10929 741093014452 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 741093014453 DNA-binding site [nucleotide binding]; DNA binding site 741093014454 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 741093014455 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741093014456 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 741093014457 GTPase RsgA; Reviewed; Region: PRK12288 741093014458 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 741093014459 RNA binding site [nucleotide binding]; other site 741093014460 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 741093014461 GTPase/Zn-binding domain interface [polypeptide binding]; other site 741093014462 GTP/Mg2+ binding site [chemical binding]; other site 741093014463 G4 box; other site 741093014464 G5 box; other site 741093014465 G1 box; other site 741093014466 Switch I region; other site 741093014467 G2 box; other site 741093014468 G3 box; other site 741093014469 Switch II region; other site 741093014470 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 741093014471 catalytic site [active] 741093014472 putative active site [active] 741093014473 putative substrate binding site [chemical binding]; other site 741093014474 dimer interface [polypeptide binding]; other site 741093014475 epoxyqueuosine reductase; Region: TIGR00276 741093014476 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 741093014477 putative carbohydrate kinase; Provisional; Region: PRK10565 741093014478 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 741093014479 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 741093014480 putative substrate binding site [chemical binding]; other site 741093014481 putative ATP binding site [chemical binding]; other site 741093014482 ADP-binding protein; Provisional; Region: PRK10646 741093014483 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 741093014484 AMIN domain; Region: AMIN; pfam11741 741093014485 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741093014486 active site 741093014487 metal binding site [ion binding]; metal-binding site 741093014488 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 741093014489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093014490 ATP binding site [chemical binding]; other site 741093014491 Mg2+ binding site [ion binding]; other site 741093014492 G-X-G motif; other site 741093014493 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 741093014494 ATP binding site [chemical binding]; other site 741093014495 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 741093014496 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 741093014497 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 741093014498 bacterial Hfq-like; Region: Hfq; cd01716 741093014499 hexamer interface [polypeptide binding]; other site 741093014500 Sm1 motif; other site 741093014501 RNA binding site [nucleotide binding]; other site 741093014502 Sm2 motif; other site 741093014503 GTPase HflX; Provisional; Region: PRK11058 741093014504 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 741093014505 HflX GTPase family; Region: HflX; cd01878 741093014506 G1 box; other site 741093014507 GTP/Mg2+ binding site [chemical binding]; other site 741093014508 Switch I region; other site 741093014509 G2 box; other site 741093014510 G3 box; other site 741093014511 Switch II region; other site 741093014512 G4 box; other site 741093014513 G5 box; other site 741093014514 FtsH protease regulator HflK; Provisional; Region: PRK10930 741093014515 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 741093014516 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 741093014517 FtsH protease regulator HflC; Provisional; Region: PRK11029 741093014518 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 741093014519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 741093014520 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 741093014521 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 741093014522 GDP-binding site [chemical binding]; other site 741093014523 ACT binding site; other site 741093014524 IMP binding site; other site 741093014525 Predicted transcriptional regulator [Transcription]; Region: COG1959 741093014526 transcriptional repressor NsrR; Provisional; Region: PRK11014 741093014527 exoribonuclease R; Provisional; Region: PRK11642 741093014528 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 741093014529 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 741093014530 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 741093014531 RNB domain; Region: RNB; pfam00773 741093014532 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 741093014533 RNA binding site [nucleotide binding]; other site 741093014534 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 741093014535 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 741093014536 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 741093014537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 741093014538 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 741093014539 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 741093014540 Predicted membrane protein [Function unknown]; Region: COG3766 741093014541 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 741093014542 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 741093014543 Predicted integral membrane protein [Function unknown]; Region: COG5463 741093014544 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 741093014545 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 741093014546 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 741093014547 FAD binding site [chemical binding]; other site 741093014548 substrate binding site [chemical binding]; other site 741093014549 catalytic residues [active] 741093014550 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093014551 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 741093014552 esterase; Provisional; Region: PRK10566 741093014553 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741093014554 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741093014555 transcriptional repressor UlaR; Provisional; Region: PRK13509 741093014556 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741093014557 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741093014558 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 741093014559 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 741093014560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 741093014561 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 741093014562 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 741093014563 active site 741093014564 P-loop; other site 741093014565 phosphorylation site [posttranslational modification] 741093014566 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741093014567 active site 741093014568 phosphorylation site [posttranslational modification] 741093014569 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 741093014570 active site 741093014571 dimer interface [polypeptide binding]; other site 741093014572 magnesium binding site [ion binding]; other site 741093014573 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 741093014574 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 741093014575 AP (apurinic/apyrimidinic) site pocket; other site 741093014576 DNA interaction; other site 741093014577 Metal-binding active site; metal-binding site 741093014578 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 741093014579 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 741093014580 intersubunit interface [polypeptide binding]; other site 741093014581 active site 741093014582 Zn2+ binding site [ion binding]; other site 741093014583 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741093014584 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 741093014585 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 741093014586 dimer interface [polypeptide binding]; other site 741093014587 ssDNA binding site [nucleotide binding]; other site 741093014588 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093014589 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 741093014590 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 741093014591 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 741093014592 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 741093014593 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 741093014594 Transposase IS200 like; Region: Y1_Tnp; pfam01797 741093014595 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 741093014596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 741093014597 Probable transposase; Region: OrfB_IS605; pfam01385 741093014598 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 741093014599 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 741093014600 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 741093014601 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 741093014602 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 741093014603 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741093014604 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 741093014605 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 741093014606 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 741093014607 Hemerythrin-like domain; Region: Hr-like; cd12108 741093014608 Fe binding site [ion binding]; other site 741093014609 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 741093014610 EamA-like transporter family; Region: EamA; pfam00892 741093014611 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 741093014612 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 741093014613 NADP binding site [chemical binding]; other site 741093014614 Predicted transcriptional regulators [Transcription]; Region: COG1733 741093014615 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 741093014616 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 741093014617 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 741093014618 active site 741093014619 metal binding site [ion binding]; metal-binding site 741093014620 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 741093014621 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 741093014622 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 741093014623 active site 741093014624 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 741093014625 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 741093014626 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 741093014627 Domain of unknown function DUF21; Region: DUF21; pfam01595 741093014628 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741093014629 Transporter associated domain; Region: CorC_HlyC; smart01091 741093014630 methionine sulfoxide reductase A; Provisional; Region: PRK00058 741093014631 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 741093014632 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741093014633 Surface antigen; Region: Bac_surface_Ag; pfam01103 741093014634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 741093014635 Family of unknown function (DUF490); Region: DUF490; pfam04357 741093014636 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 741093014637 putative active site pocket [active] 741093014638 dimerization interface [polypeptide binding]; other site 741093014639 putative catalytic residue [active] 741093014640 hypothetical protein; Provisional; Region: PRK09719 741093014641 antitoxin ChpS; Provisional; Region: PRK11347 741093014642 toxin ChpB; Provisional; Region: PRK09812 741093014643 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 741093014644 dimer interface [polypeptide binding]; other site 741093014645 substrate binding site [chemical binding]; other site 741093014646 metal binding sites [ion binding]; metal-binding site 741093014647 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 741093014648 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741093014649 putative ligand binding site [chemical binding]; other site 741093014650 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741093014651 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741093014652 Walker A/P-loop; other site 741093014653 ATP binding site [chemical binding]; other site 741093014654 Q-loop/lid; other site 741093014655 ABC transporter signature motif; other site 741093014656 Walker B; other site 741093014657 D-loop; other site 741093014658 H-loop/switch region; other site 741093014659 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741093014660 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093014661 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093014662 TM-ABC transporter signature motif; other site 741093014663 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741093014664 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741093014665 TM-ABC transporter signature motif; other site 741093014666 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 741093014667 AMP binding site [chemical binding]; other site 741093014668 metal binding site [ion binding]; metal-binding site 741093014669 active site 741093014670 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 741093014671 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741093014672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741093014673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741093014674 hypothetical protein; Provisional; Region: PRK05255 741093014675 peptidase PmbA; Provisional; Region: PRK11040 741093014676 cytochrome b562; Provisional; Region: PRK15058 741093014677 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 741093014678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093014679 FeS/SAM binding site; other site 741093014680 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 741093014681 ATP cone domain; Region: ATP-cone; pfam03477 741093014682 Class III ribonucleotide reductase; Region: RNR_III; cd01675 741093014683 effector binding site; other site 741093014684 active site 741093014685 Zn binding site [ion binding]; other site 741093014686 glycine loop; other site 741093014687 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 741093014688 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 741093014689 Ca binding site [ion binding]; other site 741093014690 active site 741093014691 catalytic site [active] 741093014692 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 741093014693 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 741093014694 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741093014695 active site turn [active] 741093014696 phosphorylation site [posttranslational modification] 741093014697 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741093014698 trehalose repressor; Provisional; Region: treR; PRK09492 741093014699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741093014700 DNA binding site [nucleotide binding] 741093014701 domain linker motif; other site 741093014702 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 741093014703 dimerization interface [polypeptide binding]; other site 741093014704 ligand binding site [chemical binding]; other site 741093014705 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 741093014706 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 741093014707 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741093014708 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 741093014709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093014710 motif II; other site 741093014711 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 741093014712 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 741093014713 homotrimer interaction site [polypeptide binding]; other site 741093014714 putative active site [active] 741093014715 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 741093014716 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 741093014717 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 741093014718 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 741093014719 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 741093014720 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 741093014721 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 741093014722 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 741093014723 homotrimer interaction site [polypeptide binding]; other site 741093014724 putative active site [active] 741093014725 oxidoreductase; Provisional; Region: PRK12742 741093014726 classical (c) SDRs; Region: SDR_c; cd05233 741093014727 NAD(P) binding site [chemical binding]; other site 741093014728 active site 741093014729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741093014730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741093014731 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 741093014732 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 741093014733 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 741093014734 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 741093014735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 741093014736 RNase E inhibitor protein; Provisional; Region: PRK11191 741093014737 Predicted membrane protein [Function unknown]; Region: COG4269 741093014738 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 741093014739 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 741093014740 HIGH motif; other site 741093014741 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 741093014742 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 741093014743 active site 741093014744 KMSKS motif; other site 741093014745 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 741093014746 tRNA binding surface [nucleotide binding]; other site 741093014747 anticodon binding site; other site 741093014748 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 741093014749 DNA polymerase III subunit chi; Validated; Region: PRK05728 741093014750 multifunctional aminopeptidase A; Provisional; Region: PRK00913 741093014751 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 741093014752 interface (dimer of trimers) [polypeptide binding]; other site 741093014753 Substrate-binding/catalytic site; other site 741093014754 Zn-binding sites [ion binding]; other site 741093014755 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 741093014756 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 741093014757 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 741093014758 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 741093014759 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 741093014760 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 741093014761 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 741093014762 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 741093014763 putative NAD(P) binding site [chemical binding]; other site 741093014764 putative substrate binding site [chemical binding]; other site 741093014765 catalytic Zn binding site [ion binding]; other site 741093014766 structural Zn binding site [ion binding]; other site 741093014767 dimer interface [polypeptide binding]; other site 741093014768 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741093014769 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 741093014770 Int/Topo IB signature motif; other site 741093014771 Transposase; Region: HTH_Tnp_1; cl17663 741093014772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093014773 putative transposase OrfB; Reviewed; Region: PHA02517 741093014774 HTH-like domain; Region: HTH_21; pfam13276 741093014775 Integrase core domain; Region: rve; pfam00665 741093014776 Integrase core domain; Region: rve_3; pfam13683 741093014777 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 741093014778 NIPSNAP; Region: NIPSNAP; pfam07978 741093014779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 741093014780 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 741093014781 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 741093014782 catalytic residues [active] 741093014783 catalytic nucleophile [active] 741093014784 Presynaptic Site I dimer interface [polypeptide binding]; other site 741093014785 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 741093014786 Synaptic Flat tetramer interface [polypeptide binding]; other site 741093014787 Synaptic Site I dimer interface [polypeptide binding]; other site 741093014788 DNA binding site [nucleotide binding] 741093014789 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 741093014790 DNA-binding interface [nucleotide binding]; DNA binding site 741093014791 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741093014792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093014793 non-specific DNA binding site [nucleotide binding]; other site 741093014794 salt bridge; other site 741093014795 sequence-specific DNA binding site [nucleotide binding]; other site 741093014796 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741093014797 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 741093014798 HNH endonuclease; Region: HNH_2; pfam13391 741093014799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 741093014800 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741093014801 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093014802 active site 741093014803 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 741093014804 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741093014805 ligand binding site [chemical binding]; other site 741093014806 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 741093014807 Capsid triplex subunit 2; Provisional; Region: PHA03259 741093014808 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 741093014809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093014810 ATP binding site [chemical binding]; other site 741093014811 putative Mg++ binding site [ion binding]; other site 741093014812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093014813 nucleotide binding region [chemical binding]; other site 741093014814 ATP-binding site [chemical binding]; other site 741093014815 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 741093014816 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 741093014817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093014818 ATP binding site [chemical binding]; other site 741093014819 putative Mg++ binding site [ion binding]; other site 741093014820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093014821 nucleotide binding region [chemical binding]; other site 741093014822 ATP-binding site [chemical binding]; other site 741093014823 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 741093014824 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 741093014825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093014826 ATP binding site [chemical binding]; other site 741093014827 putative Mg++ binding site [ion binding]; other site 741093014828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741093014829 ATP-binding site [chemical binding]; other site 741093014830 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 741093014831 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 741093014832 Part of AAA domain; Region: AAA_19; pfam13245 741093014833 Family description; Region: UvrD_C_2; pfam13538 741093014834 Domain of unknown function (DUF303); Region: DUF303; pfam03629 741093014835 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 741093014836 Kelch motif; Region: Kelch_1; pfam01344 741093014837 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 741093014838 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 741093014839 Int/Topo IB signature motif; other site 741093014840 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 741093014841 Int/Topo IB signature motif; other site 741093014842 Fimbrial protein; Region: Fimbrial; cl01416 741093014843 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093014844 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 741093014845 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741093014846 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741093014847 outer membrane usher protein; Provisional; Region: PRK15193 741093014848 PapC N-terminal domain; Region: PapC_N; pfam13954 741093014849 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741093014850 PapC C-terminal domain; Region: PapC_C; pfam13953 741093014851 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093014852 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741093014853 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 741093014854 mannosyl binding site [chemical binding]; other site 741093014855 Fimbrial protein; Region: Fimbrial; pfam00419 741093014856 fructuronate transporter; Provisional; Region: PRK10034 741093014857 gluconate transporter; Region: gntP; TIGR00791 741093014858 mannonate dehydratase; Region: uxuA; TIGR00695 741093014859 mannonate dehydratase; Provisional; Region: PRK03906 741093014860 D-mannonate oxidoreductase; Provisional; Region: PRK15037 741093014861 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741093014862 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741093014863 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 741093014864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093014865 DNA-binding site [nucleotide binding]; DNA binding site 741093014866 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741093014867 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 741093014868 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 741093014869 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 741093014870 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 741093014871 dimer interface [polypeptide binding]; other site 741093014872 active site 741093014873 hypothetical protein; Provisional; Region: PRK10519 741093014874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 741093014875 Nucleoside recognition; Region: Gate; pfam07670 741093014876 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 741093014877 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 741093014878 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014879 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014880 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014881 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014882 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014883 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014884 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014885 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741093014886 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 741093014887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741093014888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014889 putative substrate translocation pore; other site 741093014890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 741093014891 SdiA-regulated; Region: SdiA-regulated; cd09971 741093014892 putative active site [active] 741093014893 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 741093014894 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014898 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741093014899 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 741093014900 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 741093014901 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 741093014902 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 741093014903 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 741093014904 Predicted membrane protein [Function unknown]; Region: COG2733 741093014905 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 741093014906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014907 putative substrate translocation pore; other site 741093014908 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 741093014909 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741093014910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741093014911 DNA-binding site [nucleotide binding]; DNA binding site 741093014912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741093014913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741093014914 homodimer interface [polypeptide binding]; other site 741093014915 catalytic residue [active] 741093014916 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 741093014917 endoribonuclease SymE; Provisional; Region: PRK13605 741093014918 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 741093014919 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 741093014920 HsdM N-terminal domain; Region: HsdM_N; pfam12161 741093014921 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 741093014922 Methyltransferase domain; Region: Methyltransf_26; pfam13659 741093014923 S-adenosylmethionine binding site [chemical binding]; other site 741093014924 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 741093014925 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 741093014926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741093014927 ATP binding site [chemical binding]; other site 741093014928 putative Mg++ binding site [ion binding]; other site 741093014929 Uncharacterized conserved protein [Function unknown]; Region: COG1479 741093014930 Protein of unknown function DUF262; Region: DUF262; pfam03235 741093014931 Protein of unknown function DUF262; Region: DUF262; pfam03235 741093014932 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 741093014933 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 741093014934 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 741093014935 P-loop, Walker A motif; other site 741093014936 Base recognition motif; other site 741093014937 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 741093014938 Uncharacterized small protein [Function unknown]; Region: COG2879 741093014939 carbon starvation protein A; Provisional; Region: PRK15015 741093014940 Carbon starvation protein CstA; Region: CstA; pfam02554 741093014941 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 741093014942 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 741093014943 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741093014944 dimer interface [polypeptide binding]; other site 741093014945 ligand binding site [chemical binding]; other site 741093014946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093014947 dimerization interface [polypeptide binding]; other site 741093014948 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741093014949 dimer interface [polypeptide binding]; other site 741093014950 putative CheW interface [polypeptide binding]; other site 741093014951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741093014952 D-galactonate transporter; Region: 2A0114; TIGR00893 741093014953 putative substrate translocation pore; other site 741093014954 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741093014955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 741093014956 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741093014957 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741093014958 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 741093014959 putative NAD(P) binding site [chemical binding]; other site 741093014960 catalytic Zn binding site [ion binding]; other site 741093014961 structural Zn binding site [ion binding]; other site 741093014962 phosphoglycerol transferase I; Provisional; Region: PRK03776 741093014963 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 741093014964 hypothetical protein; Provisional; Region: PRK11667 741093014965 DNA replication protein DnaC; Validated; Region: PRK07952 741093014966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741093014967 Walker A motif; other site 741093014968 ATP binding site [chemical binding]; other site 741093014969 Walker B motif; other site 741093014970 primosomal protein DnaI; Provisional; Region: PRK02854 741093014971 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 741093014972 Uncharacterized conserved protein [Function unknown]; Region: COG2966 741093014973 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 741093014974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741093014975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093014976 DNA binding residues [nucleotide binding] 741093014977 dimerization interface [polypeptide binding]; other site 741093014978 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 741093014979 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741093014980 DNA binding residues [nucleotide binding] 741093014981 dimerization interface [polypeptide binding]; other site 741093014982 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 741093014983 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 741093014984 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 741093014985 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 741093014986 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 741093014987 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 741093014988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093014989 S-adenosylmethionine binding site [chemical binding]; other site 741093014990 DNA polymerase III subunit psi; Validated; Region: PRK06856 741093014991 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 741093014992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741093014993 Coenzyme A binding pocket [chemical binding]; other site 741093014994 dUMP phosphatase; Provisional; Region: PRK09449 741093014995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093014996 motif II; other site 741093014997 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 741093014998 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 741093014999 G1 box; other site 741093015000 putative GEF interaction site [polypeptide binding]; other site 741093015001 GTP/Mg2+ binding site [chemical binding]; other site 741093015002 Switch I region; other site 741093015003 G2 box; other site 741093015004 G3 box; other site 741093015005 Switch II region; other site 741093015006 G4 box; other site 741093015007 G5 box; other site 741093015008 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 741093015009 periplasmic protein; Provisional; Region: PRK10568 741093015010 BON domain; Region: BON; pfam04972 741093015011 BON domain; Region: BON; pfam04972 741093015012 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 741093015013 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 741093015014 active site 741093015015 nucleophile elbow; other site 741093015016 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 741093015017 active site 741093015018 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 741093015019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741093015020 FeS/SAM binding site; other site 741093015021 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 741093015022 intersubunit interface [polypeptide binding]; other site 741093015023 active site 741093015024 catalytic residue [active] 741093015025 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 741093015026 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 741093015027 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 741093015028 phosphopentomutase; Provisional; Region: PRK05362 741093015029 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 741093015030 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 741093015031 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 741093015032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093015033 non-specific DNA binding site [nucleotide binding]; other site 741093015034 salt bridge; other site 741093015035 sequence-specific DNA binding site [nucleotide binding]; other site 741093015036 unknown domain/lipoate-protein ligase A fusion protein; Provisional; Region: PRK14061 741093015037 hypothetical protein; Provisional; Region: PRK11246 741093015038 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 741093015039 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 741093015040 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 741093015041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741093015042 motif II; other site 741093015043 DNA repair protein RadA; Region: sms; TIGR00416 741093015044 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 741093015045 Walker A motif/ATP binding site; other site 741093015046 ATP binding site [chemical binding]; other site 741093015047 Walker B motif; other site 741093015048 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 741093015049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741093015050 non-specific DNA binding site [nucleotide binding]; other site 741093015051 salt bridge; other site 741093015052 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 741093015053 sequence-specific DNA binding site [nucleotide binding]; other site 741093015054 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 741093015055 active site 741093015056 (T/H)XGH motif; other site 741093015057 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 741093015058 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 741093015059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741093015060 Walker A/P-loop; other site 741093015061 ATP binding site [chemical binding]; other site 741093015062 Q-loop/lid; other site 741093015063 ABC transporter signature motif; other site 741093015064 Walker B; other site 741093015065 D-loop; other site 741093015066 H-loop/switch region; other site 741093015067 ABC transporter; Region: ABC_tran_2; pfam12848 741093015068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741093015069 lytic murein transglycosylase; Provisional; Region: PRK11619 741093015070 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741093015071 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741093015072 catalytic residue [active] 741093015073 Trp operon repressor; Provisional; Region: PRK01381 741093015074 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 741093015075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741093015076 catalytic core [active] 741093015077 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 741093015078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741093015079 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 741093015080 hypothetical protein; Provisional; Region: PRK10756 741093015081 CreA protein; Region: CreA; pfam05981 741093015082 DNA-binding response regulator CreB; Provisional; Region: PRK11083 741093015083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093015084 active site 741093015085 phosphorylation site [posttranslational modification] 741093015086 intermolecular recognition site; other site 741093015087 dimerization interface [polypeptide binding]; other site 741093015088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093015089 DNA binding site [nucleotide binding] 741093015090 sensory histidine kinase CreC; Provisional; Region: PRK11100 741093015091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741093015092 dimerization interface [polypeptide binding]; other site 741093015093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741093015094 dimer interface [polypeptide binding]; other site 741093015095 phosphorylation site [posttranslational modification] 741093015096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741093015097 ATP binding site [chemical binding]; other site 741093015098 Mg2+ binding site [ion binding]; other site 741093015099 G-X-G motif; other site 741093015100 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 741093015101 two-component response regulator; Provisional; Region: PRK11173 741093015102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741093015103 active site 741093015104 phosphorylation site [posttranslational modification] 741093015105 intermolecular recognition site; other site 741093015106 dimerization interface [polypeptide binding]; other site 741093015107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741093015108 DNA binding site [nucleotide binding] 741093015109 putative RNA methyltransferase; Provisional; Region: PRK10433 741093015110 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 741093015111 Peptidase M66; Region: Peptidase_M66; pfam10462 741093015112 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 741093015113 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 741093015114 type II secretion system protein D; Region: type_II_gspD; TIGR02517 741093015115 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741093015116 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741093015117 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741093015118 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741093015119 type II secretion system protein E; Region: type_II_gspE; TIGR02533 741093015120 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 741093015121 Walker A motif; other site 741093015122 ATP binding site [chemical binding]; other site 741093015123 Walker B motif; other site 741093015124 type II secretion system protein F; Region: GspF; TIGR02120 741093015125 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741093015126 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741093015127 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 741093015128 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 741093015129 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 741093015130 type II secretion system protein I; Region: gspI; TIGR01707 741093015131 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 741093015132 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 741093015133 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 741093015134 type II secretion system protein J; Region: gspJ; TIGR01711 741093015135 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 741093015136 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 741093015137 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 741093015138 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 741093015139 GspL periplasmic domain; Region: GspL_C; pfam12693 741093015140 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 741093015141 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 741093015142 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 741093015143 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 741093015144 lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004 741093015145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093015146 Transposase; Region: HTH_Tnp_1; pfam01527 741093015147 putative transposase OrfB; Reviewed; Region: PHA02517 741093015148 HTH-like domain; Region: HTH_21; pfam13276 741093015149 Integrase core domain; Region: rve; pfam00665 741093015150 Integrase core domain; Region: rve_3; pfam13683 741093015151 RTX toxin acyltransferase family; Region: HlyC; pfam02794 741093015152 RTX N-terminal domain; Region: RTX; pfam02382 741093015153 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 741093015154 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 741093015155 RTX C-terminal domain; Region: RTX_C; pfam08339 741093015156 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 741093015157 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 741093015158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741093015159 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 741093015160 Walker A/P-loop; other site 741093015161 ATP binding site [chemical binding]; other site 741093015162 Q-loop/lid; other site 741093015163 ABC transporter signature motif; other site 741093015164 Walker B; other site 741093015165 D-loop; other site 741093015166 H-loop/switch region; other site 741093015167 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 741093015168 HlyD family secretion protein; Region: HlyD_3; pfam13437 741093015169 MarR family; Region: MarR_2; cl17246 741093015170 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 741093015171 active site 741093015172 catalytic residues [active] 741093015173 DNA binding site [nucleotide binding] 741093015174 Int/Topo IB signature motif; other site 741093015175 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 741093015176 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 741093015177 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 741093015178 Phage integrase family; Region: Phage_integrase; pfam00589 741093015179 active site 741093015180 DNA binding site [nucleotide binding] 741093015181 Int/Topo IB signature motif; other site 741093015182 putative transposase OrfB; Reviewed; Region: PHA02517 741093015183 HTH-like domain; Region: HTH_21; pfam13276 741093015184 Integrase core domain; Region: rve; pfam00665 741093015185 Integrase core domain; Region: rve_3; pfam13683 741093015186 Transposase; Region: HTH_Tnp_1; cl17663 741093015187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093015188 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 741093015189 MerR family regulatory protein; Region: MerR; pfam00376 741093015190 DNA binding residues [nucleotide binding] 741093015191 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 741093015192 P-loop; other site 741093015193 Magnesium ion binding site [ion binding]; other site 741093015194 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 741093015195 Magnesium ion binding site [ion binding]; other site 741093015196 plasmid-partitioning protein; Provisional; Region: PRK13698 741093015197 ParB-like nuclease domain; Region: ParB; smart00470 741093015198 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 741093015199 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 741093015200 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 741093015201 putative active site [active] 741093015202 putative NTP binding site [chemical binding]; other site 741093015203 putative nucleic acid binding site [nucleotide binding]; other site 741093015204 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 741093015205 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741093015206 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741093015207 active site 741093015208 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 741093015209 putative methylase; Provisional; Region: PRK13699 741093015210 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741093015211 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 741093015212 Protein of unknown function (DUF1472); Region: DUF1472; pfam07339 741093015213 Antirestriction protein; Region: Antirestrict; pfam03230 741093015214 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 741093015215 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 741093015216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741093015217 S-adenosylmethionine binding site [chemical binding]; other site 741093015218 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 741093015219 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 741093015220 dimer interface [polypeptide binding]; other site 741093015221 ssDNA binding site [nucleotide binding]; other site 741093015222 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741093015223 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 741093015224 ParB-like nuclease domain; Region: ParBc; pfam02195 741093015225 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 741093015226 KorB domain; Region: KorB; pfam08535 741093015227 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 741093015228 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 741093015229 small toxic polypeptide; Provisional; Region: PRK09738 741093015230 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 741093015231 TolA C-terminal; Region: TolA; pfam06519 741093015232 Integrase core domain; Region: rve; pfam00665 741093015233 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 741093015234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 741093015235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 741093015236 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 741093015237 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 741093015238 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 741093015239 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 741093015240 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 741093015241 putative transposase OrfB; Reviewed; Region: PHA02517 741093015242 Transposase; Region: HTH_Tnp_1; cl17663 741093015243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741093015244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 741093015245 DNA helicase TraI; Region: TraI; pfam07057 741093015246 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 741093015247 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741093015248 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741093015249 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 741093015250 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 741093015251 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 741093015252 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 741093015253 putative RNA binding sites [nucleotide binding]; other site 741093015254 Staphylococcal nuclease homologues; Region: SNc; smart00318 741093015255 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 741093015256 Catalytic site; other site 741093015257 Haemolysin expression modulating protein; Region: HHA; pfam05321 741093015258 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 741093015259 replication protein; Provisional; Region: PRK13702 741093015260 replication protein; Provisional; Region: PRK13750 741093015261 Predicted transcriptional regulator [Transcription]; Region: COG3905 741093015262 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 741093015263 Putative transposase; Region: Y2_Tnp; pfam04986 741093015264 Integrase core domain; Region: rve; pfam00665 741093015265 Integrase core domain; Region: rve_3; pfam13683 741093015266 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 741093015267 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 741093015268 dimer interface [polypeptide binding]; other site 741093015269 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 741093015270 active site 741093015271 heme binding site [chemical binding]; other site 741093015272 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 741093015273 Cytochrome b562; Region: Cytochrom_B562; pfam07361 741093015274 putative transposase OrfB; Reviewed; Region: PHA02517 741093015275 HTH-like domain; Region: HTH_21; pfam13276 741093015276 Integrase core domain; Region: rve; pfam00665 741093015277 Integrase core domain; Region: rve_3; pfam13683 741093015278 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 741093015279 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 741093015280 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 741093015281 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741093015282 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741093015283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 741093015284 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 741093015285 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 741093015286 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 741093015287 putative active site [active] 741093015288 putative metal binding site [ion binding]; other site 741093015289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741093015290 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 741093015291 hypothetical protein; Provisional; Region: PRK10649 741093015292 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741093015293 Sulfatase; Region: Sulfatase; pfam00884 741093015294 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741093015295 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741093015296 putative acyl-acceptor binding pocket; other site