-- dump date 20140619_090914 -- class Genbank::misc_feature -- table misc_feature_note -- id note 439855000001 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 439855000002 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 439855000003 Rop protein; Region: Rop; pfam01815 439855000004 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 439855000005 Colicin pore forming domain; Region: Colicin; pfam01024 439855000006 Initiator Replication protein; Region: Rep_3; pfam01051 439855000007 MobA/MobL family; Region: MobA_MobL; pfam03389 439855000008 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 439855000009 replication protein; Provisional; Region: PRK13750 439855000010 replication protein; Provisional; Region: PRK13702 439855000011 Haemolysin expression modulating protein; Region: HHA; pfam05321 439855000012 Staphylococcal nuclease homologues; Region: SNc; smart00318 439855000013 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 439855000014 Catalytic site; other site 439855000015 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 439855000016 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 439855000017 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 439855000018 putative RNA binding sites [nucleotide binding]; other site 439855000019 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 439855000020 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 439855000021 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 439855000022 AAA domain; Region: AAA_30; pfam13604 439855000023 DNA helicase TraI; Region: TraI; pfam07057 439855000024 conjugal transfer protein TraD; Provisional; Region: PRK13700 439855000025 F sex factor protein N terminal; Region: TraD_N; pfam12615 439855000026 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 439855000027 multimer interface [polypeptide binding]; other site 439855000028 Walker A motif; other site 439855000029 ATP binding site [chemical binding]; other site 439855000030 Walker B motif; other site 439855000031 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 439855000032 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 439855000033 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 439855000034 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 439855000035 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 439855000036 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 439855000037 conjugal transfer protein TrbB; Provisional; Region: PRK13728 439855000038 Type-F conjugative transfer system pilin chaperone (TraQ); Region: TraQ; cl11516 439855000039 conjugal transfer protein TrbA; Provisional; Region: PRK13712 439855000040 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 439855000041 F plasmid transfer operon protein; Region: TraF; pfam13728 439855000042 conjugal transfer protein TrbE; Provisional; Region: PRK13718 439855000043 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 439855000044 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 439855000045 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 439855000046 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 439855000047 conjugal transfer protein TrbI; Provisional; Region: PRK13717 439855000048 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 439855000049 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 439855000050 conjugal transfer protein TraR; Provisional; Region: PRK13715 439855000051 conjugal transfer protein TraV; Provisional; Region: PRK13733 439855000052 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 439855000053 conjugal transfer protein TrbG; Provisional; Region: PRK13744 439855000054 conjugal transfer protein TrbD; Provisional; Region: PRK13724 439855000055 conjugal transfer protein TraP; Provisional; Region: PRK13739 439855000056 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 439855000057 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 439855000058 conjugal transfer protein TraK; Provisional; Region: PRK13736 439855000059 TraK protein; Region: TraK; pfam06586 439855000060 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 439855000061 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 439855000062 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 439855000063 conjugal transfer protein TraY; Provisional; Region: PRK13740 439855000064 PAS fold; Region: PAS; pfam00989 439855000065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 439855000066 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 439855000067 G4 box; other site 439855000068 G5 box; other site 439855000069 conjugal transfer protein TraM; Provisional; Region: PRK13713 439855000070 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 439855000071 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855000072 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855000073 catalytic residue [active] 439855000074 Domain of unknown function (DUF932); Region: DUF932; pfam06067 439855000075 small toxic polypeptide; Provisional; Region: PRK09738 439855000076 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 439855000077 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 439855000078 ParB-like nuclease domain; Region: ParBc; pfam02195 439855000079 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 439855000080 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 439855000081 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 439855000082 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 439855000083 dimer interface [polypeptide binding]; other site 439855000084 ssDNA binding site [nucleotide binding]; other site 439855000085 tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855000086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855000087 S-adenosylmethionine binding site [chemical binding]; other site 439855000088 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 439855000089 Antirestriction protein; Region: Antirestrict; pfam03230 439855000090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 439855000091 Transposase; Region: DEDD_Tnp_IS110; pfam01548 439855000092 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 439855000093 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855000094 Protein of unknown function (DUF1472); Region: DUF1472; pfam07339 439855000095 plasmid-partitioning protein; Provisional; Region: PRK13698 439855000096 ParB-like nuclease domain; Region: ParB; smart00470 439855000097 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 439855000098 MerR family regulatory protein; Region: MerR; pfam00376 439855000099 DNA binding residues [nucleotide binding] 439855000100 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 439855000101 P-loop; other site 439855000102 Magnesium ion binding site [ion binding]; other site 439855000103 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 439855000104 Magnesium ion binding site [ion binding]; other site 439855000105 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855000106 Protein of unknown function, DUF270; Region: Otopetrin; pfam03189 439855000107 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 439855000108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855000109 ABC-ATPase subunit interface; other site 439855000110 dimer interface [polypeptide binding]; other site 439855000111 putative PBP binding regions; other site 439855000112 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 439855000113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855000114 ABC-ATPase subunit interface; other site 439855000115 dimer interface [polypeptide binding]; other site 439855000116 putative PBP binding regions; other site 439855000117 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 439855000118 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 439855000119 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 439855000120 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 439855000121 metal binding site [ion binding]; metal-binding site 439855000122 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855000123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855000124 Transposase; Region: HTH_Tnp_1; cl17663 439855000125 HTH-like domain; Region: HTH_21; pfam13276 439855000126 Integrase core domain; Region: rve; pfam00665 439855000127 DDE domain; Region: DDE_Tnp_IS240; pfam13610 439855000128 Integrase core domain; Region: rve_3; pfam13683 439855000129 Initiator Replication protein; Region: Rep_3; cl03080 439855000130 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 439855000131 active site 439855000132 catalytic residues [active] 439855000133 DNA binding site [nucleotide binding] 439855000134 Int/Topo IB signature motif; other site 439855000135 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 439855000136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 439855000137 NAD(P) binding site [chemical binding]; other site 439855000138 active site 439855000139 outer membrane protease; Reviewed; Region: PRK10993 439855000140 Transposase; Region: HTH_Tnp_1; cl17663 439855000141 putative transposase OrfB; Reviewed; Region: PHA02517 439855000142 HTH-like domain; Region: HTH_21; pfam13276 439855000143 Integrase core domain; Region: rve; pfam00665 439855000144 Integrase core domain; Region: rve_3; pfam13683 439855000145 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855000146 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855000147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855000148 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855000149 HTH-like domain; Region: HTH_21; pfam13276 439855000150 Integrase core domain; Region: rve; pfam00665 439855000151 Integrase core domain; Region: rve_3; pfam13683 439855000152 YebF-like protein; Region: YebF; cl10126 439855000153 Phage integrase family; Region: Phage_integrase; pfam00589 439855000154 active site 439855000155 DNA binding site [nucleotide binding] 439855000156 Int/Topo IB signature motif; other site 439855000157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000158 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000159 Integrase core domain; Region: rve; pfam00665 439855000160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000161 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000162 Integrase core domain; Region: rve; pfam00665 439855000163 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 439855000164 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 439855000165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000166 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000167 Integrase core domain; Region: rve; pfam00665 439855000168 integrase/recombinase; Provisional; Region: PRK15417 439855000169 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 439855000170 Int/Topo IB signature motif; other site 439855000171 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 439855000172 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 439855000173 folate binding site [chemical binding]; other site 439855000174 NADP+ binding site [chemical binding]; other site 439855000175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000176 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000177 Integrase core domain; Region: rve; pfam00665 439855000178 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 439855000179 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 439855000180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 439855000181 Transposase; Region: DEDD_Tnp_IS110; pfam01548 439855000182 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 439855000183 dihydropteroate synthase; Region: DHPS; TIGR01496 439855000184 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 439855000185 substrate binding pocket [chemical binding]; other site 439855000186 dimer interface [polypeptide binding]; other site 439855000187 inhibitor binding site; inhibition site 439855000188 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 439855000189 Phosphotransferase enzyme family; Region: APH; pfam01636 439855000190 active site 439855000191 ATP binding site [chemical binding]; other site 439855000192 antibiotic binding site [chemical binding]; other site 439855000193 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 439855000194 beta-lactamase TEM; Provisional; Region: PRK15442 439855000195 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 439855000196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000197 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000198 Integrase core domain; Region: rve; pfam00665 439855000199 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 439855000200 TAP-like protein; Region: Abhydrolase_4; pfam08386 439855000201 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 439855000202 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 439855000203 aminoglycoside resistance protein; Provisional; Region: PRK13746 439855000204 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 439855000205 active site 439855000206 NTP binding site [chemical binding]; other site 439855000207 metal binding triad [ion binding]; metal-binding site 439855000208 antibiotic binding site [chemical binding]; other site 439855000209 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 439855000210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000211 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000212 Integrase core domain; Region: rve; pfam00665 439855000213 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 439855000214 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 439855000215 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 439855000216 oligomeric interface; other site 439855000217 putative active site [active] 439855000218 homodimer interface [polypeptide binding]; other site 439855000219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855000220 Walker B; other site 439855000221 D-loop; other site 439855000222 H-loop/switch region; other site 439855000223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855000224 AAA domain; Region: AAA_21; pfam13304 439855000225 Walker A/P-loop; other site 439855000226 ATP binding site [chemical binding]; other site 439855000227 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 439855000228 putative kissing complex interaction region; other site 439855000229 putative RNA binding sites [nucleotide binding]; other site 439855000230 Predicted permease; Region: DUF318; cl17795 439855000231 Predicted permease; Region: DUF318; cl17795 439855000232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855000233 dimerization interface [polypeptide binding]; other site 439855000234 putative DNA binding site [nucleotide binding]; other site 439855000235 putative Zn2+ binding site [ion binding]; other site 439855000236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000237 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000238 Integrase core domain; Region: rve; pfam00665 439855000239 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 439855000240 tetracycline repressor protein TetR; Provisional; Region: PRK13756 439855000241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855000242 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 439855000243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855000244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855000245 putative substrate translocation pore; other site 439855000246 EamA-like transporter family; Region: EamA; pfam00892 439855000247 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 439855000248 EamA-like transporter family; Region: EamA; pfam00892 439855000249 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 439855000250 catalytic triad [active] 439855000251 conserved cis-peptide bond; other site 439855000252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000253 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000254 Integrase core domain; Region: rve; pfam00665 439855000255 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 439855000256 Phosphotransferase enzyme family; Region: APH; pfam01636 439855000257 active site 439855000258 ATP binding site [chemical binding]; other site 439855000259 antibiotic binding site [chemical binding]; other site 439855000260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 439855000261 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855000262 Integrase core domain; Region: rve; pfam00665 439855000263 PemK-like protein; Region: PemK; cl00995 439855000264 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 439855000265 CAAX protease self-immunity; Region: Abi; pfam02517 439855000266 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 439855000267 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 439855000268 putative catalytic residues [active] 439855000269 putative nucleotide binding site [chemical binding]; other site 439855000270 putative aspartate binding site [chemical binding]; other site 439855000271 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 439855000272 dimer interface [polypeptide binding]; other site 439855000273 putative threonine allosteric regulatory site; other site 439855000274 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 439855000275 putative threonine allosteric regulatory site; other site 439855000276 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 439855000277 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 439855000278 homoserine kinase; Region: thrB; TIGR00191 439855000279 Protein of unknown function; Region: YhfT; pfam10797 439855000280 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 439855000281 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 439855000282 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 439855000283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855000284 catalytic residue [active] 439855000285 hypothetical protein; Validated; Region: PRK02101 439855000286 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 439855000287 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 439855000288 transaldolase-like protein; Provisional; Region: PTZ00411 439855000289 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 439855000290 active site 439855000291 dimer interface [polypeptide binding]; other site 439855000292 catalytic residue [active] 439855000293 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 439855000294 MPT binding site; other site 439855000295 trimer interface [polypeptide binding]; other site 439855000296 hypothetical protein; Provisional; Region: PRK10659 439855000297 hypothetical protein; Provisional; Region: PRK10236 439855000298 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 439855000299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 439855000300 hypothetical protein; Provisional; Region: PRK10154 439855000301 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 439855000302 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 439855000303 nucleotide binding site [chemical binding]; other site 439855000304 NEF interaction site [polypeptide binding]; other site 439855000305 SBD interface [polypeptide binding]; other site 439855000306 chaperone protein DnaJ; Provisional; Region: PRK10767 439855000307 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 439855000308 HSP70 interaction site [polypeptide binding]; other site 439855000309 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 439855000310 substrate binding site [polypeptide binding]; other site 439855000311 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 439855000312 Zn binding sites [ion binding]; other site 439855000313 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 439855000314 dimer interface [polypeptide binding]; other site 439855000315 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 439855000316 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 439855000317 Sulfatase; Region: Sulfatase; pfam00884 439855000318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 439855000319 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 439855000320 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 439855000321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855000322 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 439855000323 putative dimerization interface [polypeptide binding]; other site 439855000324 putative alpha-glucosidase; Provisional; Region: PRK10658 439855000325 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 439855000326 putative active site [active] 439855000327 putative catalytic site [active] 439855000328 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 439855000329 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 439855000330 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 439855000331 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 439855000332 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 439855000333 active site 439855000334 Riboflavin kinase; Region: Flavokinase; smart00904 439855000335 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 439855000336 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 439855000337 HIGH motif; other site 439855000338 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 439855000339 active site 439855000340 KMSKS motif; other site 439855000341 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 439855000342 tRNA binding surface [nucleotide binding]; other site 439855000343 anticodon binding site; other site 439855000344 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 439855000345 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 439855000346 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 439855000347 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 439855000348 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 439855000349 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 439855000350 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 439855000351 active site 439855000352 tetramer interface [polypeptide binding]; other site 439855000353 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 439855000354 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 439855000355 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 439855000356 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 439855000357 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 439855000358 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 439855000359 catalytic site [active] 439855000360 subunit interface [polypeptide binding]; other site 439855000361 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 439855000362 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 439855000363 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 439855000364 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 439855000365 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 439855000366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 439855000367 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 439855000368 IMP binding site; other site 439855000369 dimer interface [polypeptide binding]; other site 439855000370 interdomain contacts; other site 439855000371 partial ornithine binding site; other site 439855000372 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 439855000373 carnitine operon protein CaiE; Provisional; Region: PRK13627 439855000374 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 439855000375 putative trimer interface [polypeptide binding]; other site 439855000376 putative metal binding site [ion binding]; other site 439855000377 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 439855000378 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 439855000379 substrate binding site [chemical binding]; other site 439855000380 oxyanion hole (OAH) forming residues; other site 439855000381 trimer interface [polypeptide binding]; other site 439855000382 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 439855000383 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 439855000384 acyl-activating enzyme (AAE) consensus motif; other site 439855000385 putative AMP binding site [chemical binding]; other site 439855000386 putative active site [active] 439855000387 putative CoA binding site [chemical binding]; other site 439855000388 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 439855000389 CoA-transferase family III; Region: CoA_transf_3; pfam02515 439855000390 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 439855000391 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 439855000392 active site 439855000393 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 439855000394 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 439855000395 Ligand binding site [chemical binding]; other site 439855000396 Electron transfer flavoprotein domain; Region: ETF; pfam01012 439855000397 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 439855000398 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 439855000399 Ligand binding site [chemical binding]; other site 439855000400 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 439855000401 putative oxidoreductase FixC; Provisional; Region: PRK10157 439855000402 ferredoxin-like protein FixX; Provisional; Region: PRK15449 439855000403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855000404 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 439855000405 putative substrate translocation pore; other site 439855000406 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 439855000407 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 439855000408 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 439855000409 TrkA-N domain; Region: TrkA_N; pfam02254 439855000410 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 439855000411 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 439855000412 folate binding site [chemical binding]; other site 439855000413 NADP+ binding site [chemical binding]; other site 439855000414 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 439855000415 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 439855000416 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 439855000417 active site 439855000418 metal binding site [ion binding]; metal-binding site 439855000419 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 439855000420 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 439855000421 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 439855000422 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 439855000423 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 439855000424 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 439855000425 SurA N-terminal domain; Region: SurA_N; pfam09312 439855000426 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 439855000427 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 439855000428 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 439855000429 OstA-like protein; Region: OstA; pfam03968 439855000430 Organic solvent tolerance protein; Region: OstA_C; pfam04453 439855000431 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 439855000432 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 439855000433 putative metal binding site [ion binding]; other site 439855000434 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 439855000435 HSP70 interaction site [polypeptide binding]; other site 439855000436 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 439855000437 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 439855000438 active site 439855000439 ATP-dependent helicase HepA; Validated; Region: PRK04914 439855000440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855000441 ATP binding site [chemical binding]; other site 439855000442 putative Mg++ binding site [ion binding]; other site 439855000443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855000444 nucleotide binding region [chemical binding]; other site 439855000445 ATP-binding site [chemical binding]; other site 439855000446 DNA polymerase II; Reviewed; Region: PRK05762 439855000447 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 439855000448 active site 439855000449 catalytic site [active] 439855000450 substrate binding site [chemical binding]; other site 439855000451 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 439855000452 active site 439855000453 metal-binding site 439855000454 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 439855000455 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 439855000456 intersubunit interface [polypeptide binding]; other site 439855000457 active site 439855000458 Zn2+ binding site [ion binding]; other site 439855000459 L-arabinose isomerase; Provisional; Region: PRK02929 439855000460 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 439855000461 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 439855000462 trimer interface [polypeptide binding]; other site 439855000463 putative substrate binding site [chemical binding]; other site 439855000464 putative metal binding site [ion binding]; other site 439855000465 ribulokinase; Provisional; Region: PRK04123 439855000466 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 439855000467 N- and C-terminal domain interface [polypeptide binding]; other site 439855000468 active site 439855000469 MgATP binding site [chemical binding]; other site 439855000470 catalytic site [active] 439855000471 metal binding site [ion binding]; metal-binding site 439855000472 carbohydrate binding site [chemical binding]; other site 439855000473 homodimer interface [polypeptide binding]; other site 439855000474 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 439855000475 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 439855000476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855000477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855000478 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 439855000479 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 439855000480 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 439855000481 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 439855000482 Walker A/P-loop; other site 439855000483 ATP binding site [chemical binding]; other site 439855000484 Q-loop/lid; other site 439855000485 ABC transporter signature motif; other site 439855000486 Walker B; other site 439855000487 D-loop; other site 439855000488 H-loop/switch region; other site 439855000489 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 439855000490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855000491 dimer interface [polypeptide binding]; other site 439855000492 conserved gate region; other site 439855000493 putative PBP binding loops; other site 439855000494 ABC-ATPase subunit interface; other site 439855000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855000496 dimer interface [polypeptide binding]; other site 439855000497 conserved gate region; other site 439855000498 putative PBP binding loops; other site 439855000499 ABC-ATPase subunit interface; other site 439855000500 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 439855000501 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 439855000502 transcriptional regulator SgrR; Provisional; Region: PRK13626 439855000503 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 439855000504 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 439855000505 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 439855000506 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 439855000507 substrate binding site [chemical binding]; other site 439855000508 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 439855000509 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 439855000510 substrate binding site [chemical binding]; other site 439855000511 ligand binding site [chemical binding]; other site 439855000512 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 439855000513 tartrate dehydrogenase; Region: TTC; TIGR02089 439855000514 2-isopropylmalate synthase; Validated; Region: PRK00915 439855000515 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 439855000516 active site 439855000517 catalytic residues [active] 439855000518 metal binding site [ion binding]; metal-binding site 439855000519 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 439855000520 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 439855000521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855000522 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 439855000523 putative substrate binding pocket [chemical binding]; other site 439855000524 putative dimerization interface [polypeptide binding]; other site 439855000525 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 439855000526 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 439855000527 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 439855000528 PYR/PP interface [polypeptide binding]; other site 439855000529 dimer interface [polypeptide binding]; other site 439855000530 TPP binding site [chemical binding]; other site 439855000531 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855000532 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 439855000533 TPP-binding site [chemical binding]; other site 439855000534 dimer interface [polypeptide binding]; other site 439855000535 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 439855000536 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 439855000537 putative valine binding site [chemical binding]; other site 439855000538 dimer interface [polypeptide binding]; other site 439855000539 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 439855000540 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 439855000541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855000542 DNA binding site [nucleotide binding] 439855000543 domain linker motif; other site 439855000544 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 439855000545 dimerization interface [polypeptide binding]; other site 439855000546 ligand binding site [chemical binding]; other site 439855000547 mraZ protein; Region: TIGR00242 439855000548 MraZ protein; Region: MraZ; pfam02381 439855000549 MraZ protein; Region: MraZ; pfam02381 439855000550 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 439855000551 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 439855000552 cell division protein FtsL; Provisional; Region: PRK10772 439855000553 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 439855000554 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 439855000555 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 439855000556 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 439855000557 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 439855000558 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 439855000559 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 439855000560 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 439855000561 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 439855000562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 439855000563 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 439855000564 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 439855000565 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 439855000566 Mg++ binding site [ion binding]; other site 439855000567 putative catalytic motif [active] 439855000568 putative substrate binding site [chemical binding]; other site 439855000569 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 439855000570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 439855000571 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 439855000572 cell division protein FtsW; Provisional; Region: PRK10774 439855000573 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 439855000574 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 439855000575 active site 439855000576 homodimer interface [polypeptide binding]; other site 439855000577 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 439855000578 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 439855000579 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 439855000580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 439855000581 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 439855000582 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 439855000583 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 439855000584 cell division protein FtsQ; Provisional; Region: PRK10775 439855000585 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 439855000586 Cell division protein FtsQ; Region: FtsQ; pfam03799 439855000587 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 439855000588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855000589 Cell division protein FtsA; Region: FtsA; pfam14450 439855000590 cell division protein FtsZ; Validated; Region: PRK09330 439855000591 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 439855000592 nucleotide binding site [chemical binding]; other site 439855000593 SulA interaction site; other site 439855000594 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 439855000595 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 439855000596 SecA regulator SecM; Provisional; Region: PRK02943 439855000597 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 439855000598 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 439855000599 SEC-C motif; Region: SEC-C; pfam02810 439855000600 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 439855000601 active site 439855000602 8-oxo-dGMP binding site [chemical binding]; other site 439855000603 nudix motif; other site 439855000604 metal binding site [ion binding]; metal-binding site 439855000605 DNA gyrase inhibitor; Reviewed; Region: PRK00418 439855000606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 439855000607 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 439855000608 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 439855000609 CoA-binding site [chemical binding]; other site 439855000610 ATP-binding [chemical binding]; other site 439855000611 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 439855000612 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 439855000613 active site 439855000614 type IV pilin biogenesis protein; Provisional; Region: PRK10573 439855000615 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 439855000616 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 439855000617 hypothetical protein; Provisional; Region: PRK10436 439855000618 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 439855000619 Walker A motif; other site 439855000620 ATP binding site [chemical binding]; other site 439855000621 Walker B motif; other site 439855000622 putative major pilin subunit; Provisional; Region: PRK10574 439855000623 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 439855000624 Pilin (bacterial filament); Region: Pilin; pfam00114 439855000625 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 439855000626 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 439855000627 dimerization interface [polypeptide binding]; other site 439855000628 active site 439855000629 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 439855000630 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 439855000631 amidase catalytic site [active] 439855000632 Zn binding residues [ion binding]; other site 439855000633 substrate binding site [chemical binding]; other site 439855000634 regulatory protein AmpE; Provisional; Region: PRK10987 439855000635 aromatic amino acid transporter; Provisional; Region: PRK10238 439855000636 Protein of unknown function (DUF796); Region: DUF796; cl01226 439855000637 S-type Pyocin; Region: Pyocin_S; pfam06958 439855000638 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 439855000639 active site 439855000640 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 439855000641 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 439855000642 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 439855000643 Transcriptional regulators [Transcription]; Region: FadR; COG2186 439855000644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855000645 DNA-binding site [nucleotide binding]; DNA binding site 439855000646 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855000647 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 439855000648 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 439855000649 dimer interface [polypeptide binding]; other site 439855000650 TPP-binding site [chemical binding]; other site 439855000651 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 439855000652 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 439855000653 E3 interaction surface; other site 439855000654 lipoyl attachment site [posttranslational modification]; other site 439855000655 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 439855000656 E3 interaction surface; other site 439855000657 lipoyl attachment site [posttranslational modification]; other site 439855000658 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 439855000659 E3 interaction surface; other site 439855000660 lipoyl attachment site [posttranslational modification]; other site 439855000661 e3 binding domain; Region: E3_binding; pfam02817 439855000662 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 439855000663 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 439855000664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 439855000665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855000666 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 439855000667 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 439855000668 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 439855000669 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 439855000670 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 439855000671 substrate binding site [chemical binding]; other site 439855000672 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 439855000673 substrate binding site [chemical binding]; other site 439855000674 ligand binding site [chemical binding]; other site 439855000675 hypothetical protein; Provisional; Region: PRK05248 439855000676 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 439855000677 spermidine synthase; Provisional; Region: PRK00811 439855000678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855000679 S-adenosylmethionine binding site [chemical binding]; other site 439855000680 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 439855000681 multicopper oxidase; Provisional; Region: PRK10965 439855000682 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 439855000683 Multicopper oxidase; Region: Cu-oxidase; pfam00394 439855000684 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 439855000685 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 439855000686 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 439855000687 Trp docking motif [polypeptide binding]; other site 439855000688 putative active site [active] 439855000689 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855000690 active site 439855000691 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 439855000692 active site clefts [active] 439855000693 zinc binding site [ion binding]; other site 439855000694 dimer interface [polypeptide binding]; other site 439855000695 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 439855000696 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 439855000697 Walker A/P-loop; other site 439855000698 ATP binding site [chemical binding]; other site 439855000699 Q-loop/lid; other site 439855000700 ABC transporter signature motif; other site 439855000701 Walker B; other site 439855000702 D-loop; other site 439855000703 H-loop/switch region; other site 439855000704 inner membrane transport permease; Provisional; Region: PRK15066 439855000705 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 439855000706 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 439855000707 active pocket/dimerization site; other site 439855000708 active site 439855000709 phosphorylation site [posttranslational modification] 439855000710 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 439855000711 putative active site [active] 439855000712 putative metal binding site [ion binding]; other site 439855000713 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 439855000714 tetramerization interface [polypeptide binding]; other site 439855000715 active site 439855000716 Uncharacterized conserved protein [Function unknown]; Region: COG5464 439855000717 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 439855000718 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 439855000719 pantoate--beta-alanine ligase; Region: panC; TIGR00018 439855000720 Pantoate-beta-alanine ligase; Region: PanC; cd00560 439855000721 active site 439855000722 ATP-binding site [chemical binding]; other site 439855000723 pantoate-binding site; other site 439855000724 HXXH motif; other site 439855000725 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 439855000726 oligomerization interface [polypeptide binding]; other site 439855000727 active site 439855000728 metal binding site [ion binding]; metal-binding site 439855000729 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 439855000730 putative fimbrial protein StaF; Provisional; Region: PRK15262 439855000731 putative fimbrial protein StaE; Provisional; Region: PRK15263 439855000732 Fimbrial protein; Region: Fimbrial; cl01416 439855000733 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 439855000734 PapC N-terminal domain; Region: PapC_N; pfam13954 439855000735 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855000736 PapC C-terminal domain; Region: PapC_C; pfam13953 439855000737 putative chaperone protein EcpD; Provisional; Region: PRK09926 439855000738 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855000739 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855000740 Fimbrial protein; Region: Fimbrial; cl01416 439855000741 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 439855000742 catalytic center binding site [active] 439855000743 ATP binding site [chemical binding]; other site 439855000744 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 439855000745 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 439855000746 active site 439855000747 NTP binding site [chemical binding]; other site 439855000748 metal binding triad [ion binding]; metal-binding site 439855000749 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 439855000750 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 439855000751 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 439855000752 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 439855000753 active site 439855000754 nucleotide binding site [chemical binding]; other site 439855000755 HIGH motif; other site 439855000756 KMSKS motif; other site 439855000757 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 439855000758 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 439855000759 2'-5' RNA ligase; Provisional; Region: PRK15124 439855000760 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 439855000761 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 439855000762 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 439855000763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855000764 ATP binding site [chemical binding]; other site 439855000765 putative Mg++ binding site [ion binding]; other site 439855000766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855000767 nucleotide binding region [chemical binding]; other site 439855000768 ATP-binding site [chemical binding]; other site 439855000769 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 439855000770 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 439855000771 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 439855000772 Transglycosylase; Region: Transgly; pfam00912 439855000773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 439855000774 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 439855000775 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855000776 N-terminal plug; other site 439855000777 ligand-binding site [chemical binding]; other site 439855000778 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 439855000779 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 439855000780 Walker A/P-loop; other site 439855000781 ATP binding site [chemical binding]; other site 439855000782 Q-loop/lid; other site 439855000783 ABC transporter signature motif; other site 439855000784 Walker B; other site 439855000785 D-loop; other site 439855000786 H-loop/switch region; other site 439855000787 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 439855000788 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 439855000789 siderophore binding site; other site 439855000790 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 439855000791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855000792 ABC-ATPase subunit interface; other site 439855000793 dimer interface [polypeptide binding]; other site 439855000794 putative PBP binding regions; other site 439855000795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855000796 ABC-ATPase subunit interface; other site 439855000797 dimer interface [polypeptide binding]; other site 439855000798 putative PBP binding regions; other site 439855000799 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 439855000800 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855000801 inhibitor-cofactor binding pocket; inhibition site 439855000802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855000803 catalytic residue [active] 439855000804 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 439855000805 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 439855000806 Cl- selectivity filter; other site 439855000807 Cl- binding residues [ion binding]; other site 439855000808 pore gating glutamate residue; other site 439855000809 dimer interface [polypeptide binding]; other site 439855000810 H+/Cl- coupling transport residue; other site 439855000811 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 439855000812 hypothetical protein; Provisional; Region: PRK10578 439855000813 UPF0126 domain; Region: UPF0126; pfam03458 439855000814 UPF0126 domain; Region: UPF0126; pfam03458 439855000815 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 439855000816 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 439855000817 cobalamin binding residues [chemical binding]; other site 439855000818 putative BtuC binding residues; other site 439855000819 dimer interface [polypeptide binding]; other site 439855000820 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 439855000821 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 439855000822 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 439855000823 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855000824 Zn2+ binding site [ion binding]; other site 439855000825 Mg2+ binding site [ion binding]; other site 439855000826 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 439855000827 serine endoprotease; Provisional; Region: PRK10942 439855000828 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 439855000829 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 439855000830 protein binding site [polypeptide binding]; other site 439855000831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 439855000832 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 439855000833 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 439855000834 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 439855000835 hypothetical protein; Provisional; Region: PRK13677 439855000836 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 439855000837 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 439855000838 trimer interface [polypeptide binding]; other site 439855000839 active site 439855000840 substrate binding site [chemical binding]; other site 439855000841 CoA binding site [chemical binding]; other site 439855000842 PII uridylyl-transferase; Provisional; Region: PRK05007 439855000843 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 439855000844 metal binding triad; other site 439855000845 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 439855000846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855000847 Zn2+ binding site [ion binding]; other site 439855000848 Mg2+ binding site [ion binding]; other site 439855000849 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 439855000850 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 439855000851 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 439855000852 active site 439855000853 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 439855000854 rRNA interaction site [nucleotide binding]; other site 439855000855 S8 interaction site; other site 439855000856 putative laminin-1 binding site; other site 439855000857 elongation factor Ts; Provisional; Region: tsf; PRK09377 439855000858 UBA/TS-N domain; Region: UBA; pfam00627 439855000859 Elongation factor TS; Region: EF_TS; pfam00889 439855000860 Elongation factor TS; Region: EF_TS; pfam00889 439855000861 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 439855000862 putative nucleotide binding site [chemical binding]; other site 439855000863 uridine monophosphate binding site [chemical binding]; other site 439855000864 homohexameric interface [polypeptide binding]; other site 439855000865 ribosome recycling factor; Reviewed; Region: frr; PRK00083 439855000866 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 439855000867 hinge region; other site 439855000868 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 439855000869 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 439855000870 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 439855000871 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 439855000872 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 439855000873 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 439855000874 catalytic residue [active] 439855000875 putative FPP diphosphate binding site; other site 439855000876 putative FPP binding hydrophobic cleft; other site 439855000877 dimer interface [polypeptide binding]; other site 439855000878 putative IPP diphosphate binding site; other site 439855000879 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 439855000880 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 439855000881 zinc metallopeptidase RseP; Provisional; Region: PRK10779 439855000882 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 439855000883 active site 439855000884 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 439855000885 protein binding site [polypeptide binding]; other site 439855000886 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 439855000887 putative substrate binding region [chemical binding]; other site 439855000888 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 439855000889 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 439855000890 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 439855000891 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 439855000892 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 439855000893 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 439855000894 Surface antigen; Region: Bac_surface_Ag; pfam01103 439855000895 periplasmic chaperone; Provisional; Region: PRK10780 439855000896 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 439855000897 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 439855000898 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 439855000899 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 439855000900 trimer interface [polypeptide binding]; other site 439855000901 active site 439855000902 UDP-GlcNAc binding site [chemical binding]; other site 439855000903 lipid binding site [chemical binding]; lipid-binding site 439855000904 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 439855000905 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 439855000906 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 439855000907 active site 439855000908 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 439855000909 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 439855000910 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 439855000911 RNA/DNA hybrid binding site [nucleotide binding]; other site 439855000912 active site 439855000913 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 439855000914 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 439855000915 putative active site [active] 439855000916 putative PHP Thumb interface [polypeptide binding]; other site 439855000917 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 439855000918 generic binding surface II; other site 439855000919 generic binding surface I; other site 439855000920 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 439855000921 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 439855000922 lysine decarboxylase LdcC; Provisional; Region: PRK15399 439855000923 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 439855000924 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 439855000925 homodimer interface [polypeptide binding]; other site 439855000926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855000927 catalytic residue [active] 439855000928 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 439855000929 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 439855000930 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 439855000931 putative metal binding site [ion binding]; other site 439855000932 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 439855000933 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 439855000934 Ligand Binding Site [chemical binding]; other site 439855000935 TilS substrate binding domain; Region: TilS; pfam09179 439855000936 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 439855000937 Rho-binding antiterminator; Provisional; Region: PRK11625 439855000938 hypothetical protein; Provisional; Region: PRK04964 439855000939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 439855000940 hypothetical protein; Provisional; Region: PRK09256 439855000941 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 439855000942 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 439855000943 NlpE N-terminal domain; Region: NlpE; pfam04170 439855000944 hypothetical protein; Provisional; Region: PRK11479 439855000945 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 439855000946 prolyl-tRNA synthetase; Provisional; Region: PRK09194 439855000947 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 439855000948 dimer interface [polypeptide binding]; other site 439855000949 motif 1; other site 439855000950 active site 439855000951 motif 2; other site 439855000952 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 439855000953 putative deacylase active site [active] 439855000954 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 439855000955 active site 439855000956 motif 3; other site 439855000957 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 439855000958 anticodon binding site; other site 439855000959 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 439855000960 homodimer interaction site [polypeptide binding]; other site 439855000961 cofactor binding site; other site 439855000962 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 439855000963 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 439855000964 lipoprotein, YaeC family; Region: TIGR00363 439855000965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855000966 dimer interface [polypeptide binding]; other site 439855000967 conserved gate region; other site 439855000968 ABC-ATPase subunit interface; other site 439855000969 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 439855000970 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 439855000971 Walker A/P-loop; other site 439855000972 ATP binding site [chemical binding]; other site 439855000973 Q-loop/lid; other site 439855000974 ABC transporter signature motif; other site 439855000975 Walker B; other site 439855000976 D-loop; other site 439855000977 H-loop/switch region; other site 439855000978 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 439855000979 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 439855000980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855000981 active site 439855000982 motif I; other site 439855000983 motif II; other site 439855000984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855000985 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855000986 active site 439855000987 catalytic tetrad [active] 439855000988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855000989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855000990 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 439855000991 putative effector binding pocket; other site 439855000992 dimerization interface [polypeptide binding]; other site 439855000993 hypothetical protein; Provisional; Region: PRK05421 439855000994 putative catalytic site [active] 439855000995 putative metal binding site [ion binding]; other site 439855000996 putative phosphate binding site [ion binding]; other site 439855000997 putative catalytic site [active] 439855000998 putative phosphate binding site [ion binding]; other site 439855000999 putative metal binding site [ion binding]; other site 439855001000 Methyltransferase domain; Region: Methyltransf_31; pfam13847 439855001001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855001002 S-adenosylmethionine binding site [chemical binding]; other site 439855001003 Flavivirus glycoprotein, central and dimerisation domains; Region: Flavi_glycoprot; pfam00869 439855001004 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 439855001005 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855001006 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855001007 catalytic residue [active] 439855001008 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 439855001009 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855001010 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 439855001011 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855001012 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 439855001013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855001014 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 439855001015 RNA/DNA hybrid binding site [nucleotide binding]; other site 439855001016 active site 439855001017 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 439855001018 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 439855001019 active site 439855001020 catalytic site [active] 439855001021 substrate binding site [chemical binding]; other site 439855001022 C-N hydrolase family amidase; Provisional; Region: PRK10438 439855001023 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 439855001024 putative active site [active] 439855001025 catalytic triad [active] 439855001026 dimer interface [polypeptide binding]; other site 439855001027 multimer interface [polypeptide binding]; other site 439855001028 C-lysozyme inhibitor; Provisional; Region: PRK09993 439855001029 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 439855001030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 439855001031 active site 439855001032 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 439855001033 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 439855001034 dimer interface [polypeptide binding]; other site 439855001035 active site 439855001036 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 439855001037 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 439855001038 putative active site [active] 439855001039 putative dimer interface [polypeptide binding]; other site 439855001040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 439855001041 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855001042 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 439855001043 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 439855001044 NlpC/P60 family; Region: NLPC_P60; pfam00877 439855001045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 439855001046 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 439855001047 FHIPEP family; Region: FHIPEP; pfam00771 439855001048 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 439855001049 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 439855001050 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 439855001051 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 439855001052 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 439855001053 flagellar motor switch protein FliN; Region: fliN; TIGR02480 439855001054 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 439855001055 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 439855001056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855001057 Walker A motif; other site 439855001058 ATP binding site [chemical binding]; other site 439855001059 Walker B motif; other site 439855001060 arginine finger; other site 439855001061 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855001062 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 439855001063 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 439855001064 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 439855001065 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 439855001066 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 439855001067 MgtE intracellular N domain; Region: MgtE_N; smart00924 439855001068 FliG C-terminal domain; Region: FliG_C; pfam01706 439855001069 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 439855001070 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 439855001071 Flagellar assembly protein FliH; Region: FliH; pfam02108 439855001072 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 439855001073 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 439855001074 Walker A motif/ATP binding site; other site 439855001075 Walker B motif; other site 439855001076 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 439855001077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 439855001078 active site 439855001079 nucleotide binding site [chemical binding]; other site 439855001080 HIGH motif; other site 439855001081 KMSKS motif; other site 439855001082 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 439855001083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 439855001084 active site 439855001085 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 439855001086 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 439855001087 FlgN protein; Region: FlgN; pfam05130 439855001088 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 439855001089 SAF-like; Region: SAF_2; pfam13144 439855001090 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 439855001091 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 439855001092 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 439855001093 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 439855001094 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 439855001095 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855001096 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 439855001097 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 439855001098 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 439855001099 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 439855001100 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855001101 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 439855001102 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855001103 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 439855001104 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855001105 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 439855001106 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 439855001107 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855001108 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 439855001109 Flagellar L-ring protein; Region: FlgH; pfam02107 439855001110 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 439855001111 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 439855001112 Rod binding protein; Region: Rod-binding; cl01626 439855001113 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 439855001114 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855001115 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 439855001116 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 439855001117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 439855001118 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 439855001119 DNA binding site [nucleotide binding] 439855001120 flagellin; Reviewed; Region: PRK08869 439855001121 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 439855001122 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 439855001123 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 439855001124 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 439855001125 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 439855001126 adenylate kinase; Region: PLN02674 439855001127 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 439855001128 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 439855001129 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 439855001130 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 439855001131 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855001132 DNA binding residues [nucleotide binding] 439855001133 flagellar motor protein MotA; Provisional; Region: PRK12482 439855001134 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 439855001135 hypothetical protein; Validated; Region: PRK06778 439855001136 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 439855001137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855001138 ligand binding site [chemical binding]; other site 439855001139 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 439855001140 active site 439855001141 DNA polymerase IV; Validated; Region: PRK02406 439855001142 DNA binding site [nucleotide binding] 439855001143 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 439855001144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 439855001145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855001146 Coenzyme A binding pocket [chemical binding]; other site 439855001147 hypothetical protein; Reviewed; Region: PRK09588 439855001148 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 439855001149 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 439855001150 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 439855001151 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 439855001152 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 439855001153 metal binding site [ion binding]; metal-binding site 439855001154 dimer interface [polypeptide binding]; other site 439855001155 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855001156 active site 439855001157 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 439855001158 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 439855001159 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 439855001160 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 439855001161 trimer interface [polypeptide binding]; other site 439855001162 eyelet of channel; other site 439855001163 gamma-glutamyl kinase; Provisional; Region: PRK05429 439855001164 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 439855001165 nucleotide binding site [chemical binding]; other site 439855001166 homotetrameric interface [polypeptide binding]; other site 439855001167 putative phosphate binding site [ion binding]; other site 439855001168 putative allosteric binding site; other site 439855001169 PUA domain; Region: PUA; pfam01472 439855001170 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 439855001171 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 439855001172 putative catalytic cysteine [active] 439855001173 integrase; Provisional; Region: PRK09692 439855001174 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 439855001175 active site 439855001176 Int/Topo IB signature motif; other site 439855001177 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 439855001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855001179 active site 439855001180 phosphorylation site [posttranslational modification] 439855001181 intermolecular recognition site; other site 439855001182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855001183 active site 439855001184 phosphorylation site [posttranslational modification] 439855001185 intermolecular recognition site; other site 439855001186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855001187 Transposase; Region: HTH_Tnp_1; cl17663 439855001188 HTH-like domain; Region: HTH_21; pfam13276 439855001189 Integrase core domain; Region: rve; pfam00665 439855001190 DDE domain; Region: DDE_Tnp_IS240; pfam13610 439855001191 Integrase core domain; Region: rve_3; pfam13683 439855001192 Antirestriction protein; Region: Antirestrict; pfam03230 439855001193 hypothetical protein; Reviewed; Region: PRK00024 439855001194 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 439855001195 MPN+ (JAMM) motif; other site 439855001196 Zinc-binding site [ion binding]; other site 439855001197 Protein of unknown function (DUF987); Region: DUF987; pfam06174 439855001198 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 439855001199 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 439855001200 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855001201 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 439855001202 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 439855001203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855001204 DNA binding residues [nucleotide binding] 439855001205 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 439855001206 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 439855001207 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 439855001208 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 439855001209 putative active site [active] 439855001210 putative FMN binding site [chemical binding]; other site 439855001211 putative substrate binding site [chemical binding]; other site 439855001212 putative catalytic residue [active] 439855001213 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 439855001214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855001215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855001216 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 439855001217 putative effector binding pocket; other site 439855001218 putative dimerization interface [polypeptide binding]; other site 439855001219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855001220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855001221 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 439855001222 putative effector binding pocket; other site 439855001223 putative dimerization interface [polypeptide binding]; other site 439855001224 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855001225 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855001226 active site 439855001227 catalytic tetrad [active] 439855001228 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855001229 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855001230 active site 439855001231 catalytic tetrad [active] 439855001232 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 439855001233 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855001234 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 439855001235 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855001236 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855001237 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855001238 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 439855001239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855001240 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 439855001241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855001242 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855001243 active site 439855001244 catalytic tetrad [active] 439855001245 Predicted membrane protein [Function unknown]; Region: COG3059 439855001246 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855001247 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 439855001248 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 439855001249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855001250 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 439855001251 Cupin; Region: Cupin_6; pfam12852 439855001252 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 439855001253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855001254 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 439855001255 Cysteine-rich domain; Region: CCG; pfam02754 439855001256 Cysteine-rich domain; Region: CCG; pfam02754 439855001257 iron-sulfur cluster-binding protein; Region: TIGR00273 439855001258 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 439855001259 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855001260 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 439855001261 Uncharacterized conserved protein [Function unknown]; Region: COG1556 439855001262 choline dehydrogenase; Validated; Region: PRK02106 439855001263 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 439855001264 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 439855001265 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 439855001266 tetrameric interface [polypeptide binding]; other site 439855001267 NAD binding site [chemical binding]; other site 439855001268 catalytic residues [active] 439855001269 transcriptional regulator BetI; Validated; Region: PRK00767 439855001270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855001271 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 439855001272 choline transport protein BetT; Provisional; Region: PRK09928 439855001273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855001274 DNA binding residues [nucleotide binding] 439855001275 dimerization interface [polypeptide binding]; other site 439855001276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855001277 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 439855001278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855001279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855001280 dimerization interface [polypeptide binding]; other site 439855001281 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 439855001282 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 439855001283 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 439855001284 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 439855001285 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 439855001286 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 439855001287 CoA binding domain; Region: CoA_binding; pfam02629 439855001288 CoA-ligase; Region: Ligase_CoA; pfam00549 439855001289 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 439855001290 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 439855001291 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 439855001292 putative substrate binding site [chemical binding]; other site 439855001293 nucleotide binding site [chemical binding]; other site 439855001294 nucleotide binding site [chemical binding]; other site 439855001295 homodimer interface [polypeptide binding]; other site 439855001296 putative deaminase; Validated; Region: PRK06846 439855001297 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 439855001298 active site 439855001299 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 439855001300 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 439855001301 putative NAD(P) binding site [chemical binding]; other site 439855001302 putative substrate binding site [chemical binding]; other site 439855001303 catalytic Zn binding site [ion binding]; other site 439855001304 structural Zn binding site [ion binding]; other site 439855001305 dimer interface [polypeptide binding]; other site 439855001306 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 439855001307 hypothetical protein; Provisional; Region: PRK09929 439855001308 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 439855001309 Propionate catabolism activator; Region: PrpR_N; pfam06506 439855001310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855001311 Walker A motif; other site 439855001312 ATP binding site [chemical binding]; other site 439855001313 Walker B motif; other site 439855001314 arginine finger; other site 439855001315 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855001316 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 439855001317 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 439855001318 tetramer interface [polypeptide binding]; other site 439855001319 active site 439855001320 Mg2+/Mn2+ binding site [ion binding]; other site 439855001321 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 439855001322 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 439855001323 dimer interface [polypeptide binding]; other site 439855001324 active site 439855001325 citrylCoA binding site [chemical binding]; other site 439855001326 oxalacetate/citrate binding site [chemical binding]; other site 439855001327 coenzyme A binding site [chemical binding]; other site 439855001328 catalytic triad [active] 439855001329 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 439855001330 2-methylcitrate dehydratase; Region: prpD; TIGR02330 439855001331 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 439855001332 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 439855001333 acyl-activating enzyme (AAE) consensus motif; other site 439855001334 putative AMP binding site [chemical binding]; other site 439855001335 putative active site [active] 439855001336 putative CoA binding site [chemical binding]; other site 439855001337 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 439855001338 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 439855001339 Na binding site [ion binding]; other site 439855001340 putative substrate binding site [chemical binding]; other site 439855001341 cytosine deaminase; Provisional; Region: PRK09230 439855001342 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 439855001343 active site 439855001344 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 439855001345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855001346 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 439855001347 dimerization interface [polypeptide binding]; other site 439855001348 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 439855001349 active site clefts [active] 439855001350 zinc binding site [ion binding]; other site 439855001351 dimer interface [polypeptide binding]; other site 439855001352 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 439855001353 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 439855001354 oligomer interface [polypeptide binding]; other site 439855001355 active site 439855001356 putative cyanate transporter; Provisional; Region: cynX; PRK09705 439855001357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001358 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 439855001359 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 439855001360 active site 439855001361 substrate binding site [chemical binding]; other site 439855001362 trimer interface [polypeptide binding]; other site 439855001363 CoA binding site [chemical binding]; other site 439855001364 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 439855001365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001366 putative substrate translocation pore; other site 439855001367 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 439855001368 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 439855001369 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 439855001370 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 439855001371 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 439855001372 lac repressor; Reviewed; Region: lacI; PRK09526 439855001373 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855001374 DNA binding site [nucleotide binding] 439855001375 domain linker motif; other site 439855001376 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 439855001377 ligand binding site [chemical binding]; other site 439855001378 dimerization interface (open form) [polypeptide binding]; other site 439855001379 dimerization interface (closed form) [polypeptide binding]; other site 439855001380 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 439855001381 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 439855001382 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855001383 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 439855001384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 439855001385 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 439855001386 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 439855001387 putative active site [active] 439855001388 Fe(II) binding site [ion binding]; other site 439855001389 putative dimer interface [polypeptide binding]; other site 439855001390 putative tetramer interface [polypeptide binding]; other site 439855001391 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 439855001392 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 439855001393 acetaldehyde dehydrogenase; Validated; Region: PRK08300 439855001394 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 439855001395 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 439855001396 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 439855001397 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 439855001398 active site 439855001399 catalytic residues [active] 439855001400 metal binding site [ion binding]; metal-binding site 439855001401 DmpG-like communication domain; Region: DmpG_comm; pfam07836 439855001402 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 439855001403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 439855001406 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 439855001407 S-formylglutathione hydrolase; Region: PLN02442 439855001408 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 439855001409 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 439855001410 substrate binding site [chemical binding]; other site 439855001411 catalytic Zn binding site [ion binding]; other site 439855001412 NAD binding site [chemical binding]; other site 439855001413 structural Zn binding site [ion binding]; other site 439855001414 dimer interface [polypeptide binding]; other site 439855001415 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 439855001416 putative metal binding site [ion binding]; other site 439855001417 putative homodimer interface [polypeptide binding]; other site 439855001418 putative homotetramer interface [polypeptide binding]; other site 439855001419 putative homodimer-homodimer interface [polypeptide binding]; other site 439855001420 putative allosteric switch controlling residues; other site 439855001421 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 439855001422 putative trimer interface [polypeptide binding]; other site 439855001423 putative CoA binding site [chemical binding]; other site 439855001424 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 439855001425 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 439855001426 DXD motif; other site 439855001427 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 439855001428 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 439855001429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855001430 substrate binding pocket [chemical binding]; other site 439855001431 membrane-bound complex binding site; other site 439855001432 hinge residues; other site 439855001433 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 439855001434 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 439855001435 Walker A/P-loop; other site 439855001436 ATP binding site [chemical binding]; other site 439855001437 Q-loop/lid; other site 439855001438 ABC transporter signature motif; other site 439855001439 Walker B; other site 439855001440 D-loop; other site 439855001441 H-loop/switch region; other site 439855001442 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 439855001443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855001444 dimer interface [polypeptide binding]; other site 439855001445 conserved gate region; other site 439855001446 putative PBP binding loops; other site 439855001447 ABC-ATPase subunit interface; other site 439855001448 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 439855001449 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 439855001450 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 439855001451 dimer interface [polypeptide binding]; other site 439855001452 active site 439855001453 Schiff base residues; other site 439855001454 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855001455 HTH-like domain; Region: HTH_21; pfam13276 439855001456 Integrase core domain; Region: rve; pfam00665 439855001457 Integrase core domain; Region: rve_3; pfam13683 439855001458 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855001459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855001460 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 439855001461 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 439855001462 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855001463 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 439855001464 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 439855001465 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 439855001466 microcin B17 transporter; Reviewed; Region: PRK11098 439855001467 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 439855001468 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 439855001469 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 439855001470 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 439855001471 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 439855001472 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 439855001473 anti-RssB factor; Provisional; Region: PRK10244 439855001474 alkaline phosphatase; Provisional; Region: PRK10518 439855001475 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 439855001476 dimer interface [polypeptide binding]; other site 439855001477 active site 439855001478 hypothetical protein; Provisional; Region: PRK11505 439855001479 psiF repeat; Region: PsiF_repeat; pfam07769 439855001480 psiF repeat; Region: PsiF_repeat; pfam07769 439855001481 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 439855001482 MASE2 domain; Region: MASE2; pfam05230 439855001483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855001484 metal binding site [ion binding]; metal-binding site 439855001485 active site 439855001486 I-site; other site 439855001487 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 439855001488 pyrroline-5-carboxylate reductase; Region: PLN02688 439855001489 hypothetical protein; Validated; Region: PRK00124 439855001490 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 439855001491 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 439855001492 ADP binding site [chemical binding]; other site 439855001493 magnesium binding site [ion binding]; other site 439855001494 putative shikimate binding site; other site 439855001495 hypothetical protein; Provisional; Region: PRK10380 439855001496 hypothetical protein; Provisional; Region: PRK10481 439855001497 hypothetical protein; Provisional; Region: PRK10579 439855001498 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 439855001499 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 439855001500 fructokinase; Reviewed; Region: PRK09557 439855001501 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855001502 nucleotide binding site [chemical binding]; other site 439855001503 MFS transport protein AraJ; Provisional; Region: PRK10091 439855001504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001505 putative substrate translocation pore; other site 439855001506 exonuclease subunit SbcC; Provisional; Region: PRK10246 439855001507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855001508 Walker A/P-loop; other site 439855001509 ATP binding site [chemical binding]; other site 439855001510 Q-loop/lid; other site 439855001511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855001512 ABC transporter signature motif; other site 439855001513 Walker B; other site 439855001514 D-loop; other site 439855001515 H-loop/switch region; other site 439855001516 exonuclease subunit SbcD; Provisional; Region: PRK10966 439855001517 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 439855001518 active site 439855001519 metal binding site [ion binding]; metal-binding site 439855001520 DNA binding site [nucleotide binding] 439855001521 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 439855001522 transcriptional regulator PhoB; Provisional; Region: PRK10161 439855001523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855001524 active site 439855001525 phosphorylation site [posttranslational modification] 439855001526 intermolecular recognition site; other site 439855001527 dimerization interface [polypeptide binding]; other site 439855001528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855001529 DNA binding site [nucleotide binding] 439855001530 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 439855001531 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 439855001532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855001533 putative active site [active] 439855001534 heme pocket [chemical binding]; other site 439855001535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855001536 dimer interface [polypeptide binding]; other site 439855001537 phosphorylation site [posttranslational modification] 439855001538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855001539 ATP binding site [chemical binding]; other site 439855001540 Mg2+ binding site [ion binding]; other site 439855001541 G-X-G motif; other site 439855001542 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 439855001543 putative proline-specific permease; Provisional; Region: proY; PRK10580 439855001544 Spore germination protein; Region: Spore_permease; cl17796 439855001545 maltodextrin glucosidase; Provisional; Region: PRK10785 439855001546 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 439855001547 homodimer interface [polypeptide binding]; other site 439855001548 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 439855001549 active site 439855001550 homodimer interface [polypeptide binding]; other site 439855001551 catalytic site [active] 439855001552 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 439855001553 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 439855001554 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 439855001555 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 439855001556 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 439855001557 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 439855001558 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 439855001559 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 439855001560 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 439855001561 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 439855001562 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 439855001563 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 439855001564 Protein export membrane protein; Region: SecD_SecF; pfam02355 439855001565 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 439855001566 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 439855001567 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 439855001568 active site 439855001569 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 439855001570 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 439855001571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 439855001572 Probable transposase; Region: OrfB_IS605; pfam01385 439855001573 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 439855001574 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 439855001575 ATP cone domain; Region: ATP-cone; pfam03477 439855001576 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 439855001577 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 439855001578 catalytic motif [active] 439855001579 Zn binding site [ion binding]; other site 439855001580 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 439855001581 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 439855001582 homopentamer interface [polypeptide binding]; other site 439855001583 active site 439855001584 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 439855001585 putative RNA binding site [nucleotide binding]; other site 439855001586 thiamine monophosphate kinase; Provisional; Region: PRK05731 439855001587 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 439855001588 ATP binding site [chemical binding]; other site 439855001589 dimerization interface [polypeptide binding]; other site 439855001590 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 439855001591 tetramer interfaces [polypeptide binding]; other site 439855001592 binuclear metal-binding site [ion binding]; other site 439855001593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855001594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855001595 active site 439855001596 catalytic tetrad [active] 439855001597 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 439855001598 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 439855001599 TPP-binding site; other site 439855001600 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 439855001601 PYR/PP interface [polypeptide binding]; other site 439855001602 dimer interface [polypeptide binding]; other site 439855001603 TPP binding site [chemical binding]; other site 439855001604 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 439855001605 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 439855001606 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 439855001607 substrate binding pocket [chemical binding]; other site 439855001608 chain length determination region; other site 439855001609 substrate-Mg2+ binding site; other site 439855001610 catalytic residues [active] 439855001611 aspartate-rich region 1; other site 439855001612 active site lid residues [active] 439855001613 aspartate-rich region 2; other site 439855001614 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 439855001615 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 439855001616 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 439855001617 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 439855001618 Ligand Binding Site [chemical binding]; other site 439855001619 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 439855001620 active site residue [active] 439855001621 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 439855001622 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 439855001623 conserved cys residue [active] 439855001624 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 439855001625 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 439855001626 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 439855001627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 439855001628 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 439855001629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855001631 putative substrate translocation pore; other site 439855001632 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 439855001633 Sel1 repeat; Region: Sel1; pfam08238 439855001634 Sel1-like repeats; Region: SEL1; smart00671 439855001635 Sel1-like repeats; Region: SEL1; smart00671 439855001636 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 439855001637 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 439855001638 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 439855001639 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 439855001640 UbiA prenyltransferase family; Region: UbiA; pfam01040 439855001641 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 439855001642 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 439855001643 Subunit I/III interface [polypeptide binding]; other site 439855001644 Subunit III/IV interface [polypeptide binding]; other site 439855001645 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 439855001646 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 439855001647 D-pathway; other site 439855001648 Putative ubiquinol binding site [chemical binding]; other site 439855001649 Low-spin heme (heme b) binding site [chemical binding]; other site 439855001650 Putative water exit pathway; other site 439855001651 Binuclear center (heme o3/CuB) [ion binding]; other site 439855001652 K-pathway; other site 439855001653 Putative proton exit pathway; other site 439855001654 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 439855001655 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 439855001656 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 439855001657 muropeptide transporter; Reviewed; Region: ampG; PRK11902 439855001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001659 putative substrate translocation pore; other site 439855001660 hypothetical protein; Provisional; Region: PRK11627 439855001661 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 439855001662 transcriptional regulator BolA; Provisional; Region: PRK11628 439855001663 trigger factor; Provisional; Region: tig; PRK01490 439855001664 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 439855001665 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 439855001666 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 439855001667 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 439855001668 oligomer interface [polypeptide binding]; other site 439855001669 active site residues [active] 439855001670 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 439855001671 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 439855001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855001673 Walker A motif; other site 439855001674 ATP binding site [chemical binding]; other site 439855001675 Walker B motif; other site 439855001676 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 439855001677 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 439855001678 Found in ATP-dependent protease La (LON); Region: LON; smart00464 439855001679 Found in ATP-dependent protease La (LON); Region: LON; smart00464 439855001680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855001681 Walker A motif; other site 439855001682 ATP binding site [chemical binding]; other site 439855001683 Walker B motif; other site 439855001684 arginine finger; other site 439855001685 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 439855001686 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 439855001687 IHF dimer interface [polypeptide binding]; other site 439855001688 IHF - DNA interface [nucleotide binding]; other site 439855001689 periplasmic folding chaperone; Provisional; Region: PRK10788 439855001690 SurA N-terminal domain; Region: SurA_N_3; cl07813 439855001691 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 439855001692 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 439855001693 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 439855001694 active site 439855001695 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 439855001696 Ligand Binding Site [chemical binding]; other site 439855001697 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 439855001698 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 439855001699 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 439855001700 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 439855001701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855001702 active site 439855001703 motif I; other site 439855001704 motif II; other site 439855001705 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 439855001706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855001707 putative DNA binding site [nucleotide binding]; other site 439855001708 putative Zn2+ binding site [ion binding]; other site 439855001709 AsnC family; Region: AsnC_trans_reg; pfam01037 439855001710 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 439855001711 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 439855001712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855001713 Walker A/P-loop; other site 439855001714 ATP binding site [chemical binding]; other site 439855001715 Q-loop/lid; other site 439855001716 ABC transporter signature motif; other site 439855001717 Walker B; other site 439855001718 D-loop; other site 439855001719 H-loop/switch region; other site 439855001720 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 439855001721 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 439855001722 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 439855001723 Walker A/P-loop; other site 439855001724 ATP binding site [chemical binding]; other site 439855001725 Q-loop/lid; other site 439855001726 ABC transporter signature motif; other site 439855001727 Walker B; other site 439855001728 D-loop; other site 439855001729 H-loop/switch region; other site 439855001730 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 439855001731 Nitrogen regulatory protein P-II; Region: P-II; smart00938 439855001732 ammonium transporter; Provisional; Region: PRK10666 439855001733 acyl-CoA thioesterase II; Provisional; Region: PRK10526 439855001734 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 439855001735 active site 439855001736 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 439855001737 catalytic triad [active] 439855001738 dimer interface [polypeptide binding]; other site 439855001739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 439855001740 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 439855001741 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 439855001742 DNA binding site [nucleotide binding] 439855001743 active site 439855001744 Uncharacterized conserved protein [Function unknown]; Region: COG5507 439855001745 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 439855001746 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 439855001747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855001748 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 439855001749 maltose O-acetyltransferase; Provisional; Region: PRK10092 439855001750 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 439855001751 active site 439855001752 substrate binding site [chemical binding]; other site 439855001753 trimer interface [polypeptide binding]; other site 439855001754 CoA binding site [chemical binding]; other site 439855001755 gene expression modulator; Provisional; Region: PRK10945 439855001756 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 439855001757 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 439855001758 Protein export membrane protein; Region: SecD_SecF; cl14618 439855001759 Protein export membrane protein; Region: SecD_SecF; cl14618 439855001760 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 439855001761 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855001762 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855001763 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 439855001764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855001765 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 439855001766 hypothetical protein; Provisional; Region: PRK11281 439855001767 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 439855001768 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 439855001769 Mechanosensitive ion channel; Region: MS_channel; pfam00924 439855001770 hypothetical protein; Provisional; Region: PRK11038 439855001771 primosomal replication protein N''; Provisional; Region: PRK10093 439855001772 hypothetical protein; Provisional; Region: PRK10527 439855001773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855001774 active site 439855001775 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 439855001776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855001777 Walker A motif; other site 439855001778 ATP binding site [chemical binding]; other site 439855001779 Walker B motif; other site 439855001780 DNA polymerase III subunit delta'; Validated; Region: PRK08485 439855001781 arginine finger; other site 439855001782 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 439855001783 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 439855001784 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 439855001785 hypothetical protein; Validated; Region: PRK00153 439855001786 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 439855001787 RecR protein; Region: RecR; pfam02132 439855001788 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 439855001789 putative active site [active] 439855001790 putative metal-binding site [ion binding]; other site 439855001791 tetramer interface [polypeptide binding]; other site 439855001792 heat shock protein 90; Provisional; Region: PRK05218 439855001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855001794 ATP binding site [chemical binding]; other site 439855001795 Mg2+ binding site [ion binding]; other site 439855001796 G-X-G motif; other site 439855001797 adenylate kinase; Reviewed; Region: adk; PRK00279 439855001798 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 439855001799 AMP-binding site [chemical binding]; other site 439855001800 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 439855001801 ferrochelatase; Region: hemH; TIGR00109 439855001802 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 439855001803 C-terminal domain interface [polypeptide binding]; other site 439855001804 active site 439855001805 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 439855001806 active site 439855001807 N-terminal domain interface [polypeptide binding]; other site 439855001808 acetyl esterase; Provisional; Region: PRK10162 439855001809 inosine/guanosine kinase; Provisional; Region: PRK15074 439855001810 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855001811 putative cation:proton antiport protein; Provisional; Region: PRK10669 439855001812 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 439855001813 TrkA-N domain; Region: TrkA_N; pfam02254 439855001814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855001815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855001816 putative substrate translocation pore; other site 439855001817 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 439855001818 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 439855001819 active site 439855001820 metal binding site [ion binding]; metal-binding site 439855001821 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 439855001822 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 439855001823 putative deacylase active site [active] 439855001824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 439855001825 copper exporting ATPase; Provisional; Region: copA; PRK10671 439855001826 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 439855001827 metal-binding site [ion binding] 439855001828 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 439855001829 metal-binding site [ion binding] 439855001830 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 439855001831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855001832 motif II; other site 439855001833 glutaminase; Reviewed; Region: PRK12356 439855001834 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 439855001835 amino acid transporter; Region: 2A0306; TIGR00909 439855001836 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 439855001837 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 439855001838 DNA binding residues [nucleotide binding] 439855001839 dimer interface [polypeptide binding]; other site 439855001840 copper binding site [ion binding]; other site 439855001841 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 439855001842 YadA-like C-terminal region; Region: YadA; pfam03895 439855001843 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 439855001844 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 439855001845 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 439855001846 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 439855001847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855001848 Walker A/P-loop; other site 439855001849 ATP binding site [chemical binding]; other site 439855001850 Q-loop/lid; other site 439855001851 ABC transporter signature motif; other site 439855001852 Walker B; other site 439855001853 D-loop; other site 439855001854 H-loop/switch region; other site 439855001855 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 439855001856 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 439855001857 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 439855001858 oxidoreductase; Provisional; Region: PRK08017 439855001859 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 439855001860 NADP binding site [chemical binding]; other site 439855001861 active site 439855001862 steroid binding site; other site 439855001863 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 439855001864 active site 439855001865 catalytic triad [active] 439855001866 oxyanion hole [active] 439855001867 switch loop; other site 439855001868 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 439855001869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 439855001870 Walker A/P-loop; other site 439855001871 ATP binding site [chemical binding]; other site 439855001872 Q-loop/lid; other site 439855001873 ABC transporter signature motif; other site 439855001874 Walker B; other site 439855001875 D-loop; other site 439855001876 H-loop/switch region; other site 439855001877 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 439855001878 FtsX-like permease family; Region: FtsX; pfam02687 439855001879 FtsX-like permease family; Region: FtsX; pfam02687 439855001880 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 439855001881 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 439855001882 active site residue [active] 439855001883 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 439855001884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855001885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855001886 dimerization interface [polypeptide binding]; other site 439855001887 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 439855001888 ureidoglycolate hydrolase; Provisional; Region: PRK03606 439855001889 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 439855001890 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 439855001891 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855001892 glyoxylate carboligase; Provisional; Region: PRK11269 439855001893 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 439855001894 PYR/PP interface [polypeptide binding]; other site 439855001895 dimer interface [polypeptide binding]; other site 439855001896 TPP binding site [chemical binding]; other site 439855001897 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855001898 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 439855001899 TPP-binding site [chemical binding]; other site 439855001900 hydroxypyruvate isomerase; Provisional; Region: PRK09997 439855001901 tartronate semialdehyde reductase; Provisional; Region: PRK15059 439855001902 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 439855001903 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 439855001904 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 439855001905 Na binding site [ion binding]; other site 439855001906 substrate binding site [chemical binding]; other site 439855001907 allantoinase; Provisional; Region: PRK08044 439855001908 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 439855001909 active site 439855001910 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 439855001911 glycerate kinase II; Provisional; Region: PRK09932 439855001912 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 439855001913 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 439855001914 Cupin domain; Region: Cupin_2; cl17218 439855001915 allantoate amidohydrolase; Region: AllC; TIGR03176 439855001916 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 439855001917 active site 439855001918 metal binding site [ion binding]; metal-binding site 439855001919 dimer interface [polypeptide binding]; other site 439855001920 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 439855001921 membrane protein FdrA; Validated; Region: PRK06091 439855001922 CoA binding domain; Region: CoA_binding; pfam02629 439855001923 CoA-ligase; Region: Ligase_CoA; pfam00549 439855001924 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 439855001925 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 439855001926 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 439855001927 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 439855001928 putative substrate binding site [chemical binding]; other site 439855001929 nucleotide binding site [chemical binding]; other site 439855001930 nucleotide binding site [chemical binding]; other site 439855001931 homodimer interface [polypeptide binding]; other site 439855001932 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 439855001933 ATP-grasp domain; Region: ATP-grasp; pfam02222 439855001934 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 439855001935 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 439855001936 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 439855001937 putative active site [active] 439855001938 putative metal binding site [ion binding]; other site 439855001939 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 439855001940 substrate binding site [chemical binding]; other site 439855001941 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 439855001942 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 439855001943 active site 439855001944 HIGH motif; other site 439855001945 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 439855001946 KMSKS motif; other site 439855001947 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 439855001948 tRNA binding surface [nucleotide binding]; other site 439855001949 anticodon binding site; other site 439855001950 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 439855001951 ribosome-associated protein; Provisional; Region: PRK11507 439855001952 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 439855001953 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 439855001954 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 439855001955 homodimer interface [polypeptide binding]; other site 439855001956 NADP binding site [chemical binding]; other site 439855001957 substrate binding site [chemical binding]; other site 439855001958 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 439855001959 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 439855001960 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855001961 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855001962 outer membrane usher protein FimD; Provisional; Region: PRK15198 439855001963 PapC N-terminal domain; Region: PapC_N; pfam13954 439855001964 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855001965 PapC C-terminal domain; Region: PapC_C; pfam13953 439855001966 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 439855001967 Fimbrial protein; Region: Fimbrial; cl01416 439855001968 transcriptional regulator FimZ; Provisional; Region: PRK09935 439855001969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855001970 active site 439855001971 phosphorylation site [posttranslational modification] 439855001972 intermolecular recognition site; other site 439855001973 dimerization interface [polypeptide binding]; other site 439855001974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855001975 DNA binding residues [nucleotide binding] 439855001976 dimerization interface [polypeptide binding]; other site 439855001977 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 439855001978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855001979 hypothetical protein; Provisional; Region: PRK09936 439855001980 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 439855001981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855001982 TPR motif; other site 439855001983 binding surface 439855001984 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 439855001985 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 439855001986 active site 439855001987 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 439855001988 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 439855001989 sensor kinase CusS; Provisional; Region: PRK09835 439855001990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855001991 dimerization interface [polypeptide binding]; other site 439855001992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855001993 dimer interface [polypeptide binding]; other site 439855001994 phosphorylation site [posttranslational modification] 439855001995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855001996 ATP binding site [chemical binding]; other site 439855001997 Mg2+ binding site [ion binding]; other site 439855001998 G-X-G motif; other site 439855001999 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 439855002000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855002001 active site 439855002002 phosphorylation site [posttranslational modification] 439855002003 intermolecular recognition site; other site 439855002004 dimerization interface [polypeptide binding]; other site 439855002005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855002006 DNA binding site [nucleotide binding] 439855002007 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 439855002008 periplasmic copper-binding protein; Provisional; Region: PRK09838 439855002009 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 439855002010 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855002011 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 439855002012 phenylalanine transporter; Provisional; Region: PRK10249 439855002013 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 439855002014 Mechanosensitive ion channel; Region: MS_channel; pfam00924 439855002015 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 439855002016 dimer interface [polypeptide binding]; other site 439855002017 FMN binding site [chemical binding]; other site 439855002018 hypothetical protein; Provisional; Region: PRK10250 439855002019 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 439855002020 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 439855002021 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 439855002022 Hok/gef family; Region: HOK_GEF; pfam01848 439855002023 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 439855002024 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 439855002025 outer membrane receptor FepA; Provisional; Region: PRK13524 439855002026 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855002027 N-terminal plug; other site 439855002028 ligand-binding site [chemical binding]; other site 439855002029 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 439855002030 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 439855002031 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 439855002032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 439855002033 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 439855002034 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 439855002035 acyl-activating enzyme (AAE) consensus motif; other site 439855002036 AMP binding site [chemical binding]; other site 439855002037 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 439855002038 LPS O-antigen length regulator; Provisional; Region: PRK10381 439855002039 Chain length determinant protein; Region: Wzz; pfam02706 439855002040 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 439855002041 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 439855002042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 439855002043 Walker A/P-loop; other site 439855002044 ATP binding site [chemical binding]; other site 439855002045 Q-loop/lid; other site 439855002046 ABC transporter signature motif; other site 439855002047 Walker B; other site 439855002048 D-loop; other site 439855002049 H-loop/switch region; other site 439855002050 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 439855002051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855002052 ABC-ATPase subunit interface; other site 439855002053 dimer interface [polypeptide binding]; other site 439855002054 putative PBP binding regions; other site 439855002055 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 439855002056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855002057 ABC-ATPase subunit interface; other site 439855002058 dimer interface [polypeptide binding]; other site 439855002059 putative PBP binding regions; other site 439855002060 enterobactin exporter EntS; Provisional; Region: PRK10489 439855002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855002062 putative substrate translocation pore; other site 439855002063 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 439855002064 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 439855002065 siderophore binding site; other site 439855002066 isochorismate synthase EntC; Provisional; Region: PRK15016 439855002067 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 439855002068 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 439855002069 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 439855002070 acyl-activating enzyme (AAE) consensus motif; other site 439855002071 active site 439855002072 AMP binding site [chemical binding]; other site 439855002073 substrate binding site [chemical binding]; other site 439855002074 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 439855002075 hydrophobic substrate binding pocket; other site 439855002076 Isochorismatase family; Region: Isochorismatase; pfam00857 439855002077 active site 439855002078 conserved cis-peptide bond; other site 439855002079 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 439855002080 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 439855002081 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 439855002082 putative NAD(P) binding site [chemical binding]; other site 439855002083 active site 439855002084 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 439855002085 CoenzymeA binding site [chemical binding]; other site 439855002086 subunit interaction site [polypeptide binding]; other site 439855002087 PHB binding site; other site 439855002088 carbon starvation protein A; Provisional; Region: PRK15015 439855002089 Carbon starvation protein CstA; Region: CstA; pfam02554 439855002090 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 439855002091 Uncharacterized small protein [Function unknown]; Region: COG2879 439855002092 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 439855002093 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 439855002094 putative active site [active] 439855002095 metal binding site [ion binding]; metal-binding site 439855002096 methionine aminotransferase; Validated; Region: PRK09082 439855002097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855002098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855002099 homodimer interface [polypeptide binding]; other site 439855002100 catalytic residue [active] 439855002101 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 439855002102 ParB-like nuclease domain; Region: ParBc; pfam02195 439855002103 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 439855002104 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 439855002105 Active Sites [active] 439855002106 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 439855002107 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 439855002108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855002109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855002110 dimerization interface [polypeptide binding]; other site 439855002111 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 439855002112 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 439855002113 dimerization domain [polypeptide binding]; other site 439855002114 dimer interface [polypeptide binding]; other site 439855002115 catalytic residues [active] 439855002116 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 439855002117 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 439855002118 dimer interface [polypeptide binding]; other site 439855002119 decamer (pentamer of dimers) interface [polypeptide binding]; other site 439855002120 catalytic triad [active] 439855002121 peroxidatic and resolving cysteines [active] 439855002122 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 439855002123 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 439855002124 catalytic residue [active] 439855002125 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 439855002126 catalytic residues [active] 439855002127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855002128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855002129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855002130 Ligand Binding Site [chemical binding]; other site 439855002131 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 439855002132 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 439855002133 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 439855002134 B1 nucleotide binding pocket [chemical binding]; other site 439855002135 B2 nucleotide binding pocket [chemical binding]; other site 439855002136 CAS motifs; other site 439855002137 active site 439855002138 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 439855002139 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 439855002140 transmembrane helices; other site 439855002141 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 439855002142 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 439855002143 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 439855002144 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 439855002145 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 439855002146 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 439855002147 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 439855002148 putative active site [active] 439855002149 (T/H)XGH motif; other site 439855002150 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 439855002151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855002152 putative active site [active] 439855002153 heme pocket [chemical binding]; other site 439855002154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855002155 ATP binding site [chemical binding]; other site 439855002156 Mg2+ binding site [ion binding]; other site 439855002157 G-X-G motif; other site 439855002158 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 439855002159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855002160 active site 439855002161 phosphorylation site [posttranslational modification] 439855002162 intermolecular recognition site; other site 439855002163 dimerization interface [polypeptide binding]; other site 439855002164 Transcriptional regulator; Region: CitT; pfam12431 439855002165 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 439855002166 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 439855002167 Transposase domain (DUF772); Region: DUF772; pfam05598 439855002168 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 439855002169 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 439855002170 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 439855002171 DNA-binding site [nucleotide binding]; DNA binding site 439855002172 RNA-binding motif; other site 439855002173 chromosome condensation membrane protein; Provisional; Region: PRK14196 439855002174 Predicted amidohydrolase [General function prediction only]; Region: COG0388 439855002175 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 439855002176 putative active site [active] 439855002177 catalytic triad [active] 439855002178 putative dimer interface [polypeptide binding]; other site 439855002179 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 439855002180 lipoyl synthase; Provisional; Region: PRK05481 439855002181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855002182 FeS/SAM binding site; other site 439855002183 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 439855002184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855002185 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 439855002186 substrate binding pocket [chemical binding]; other site 439855002187 dimerization interface [polypeptide binding]; other site 439855002188 lipoate-protein ligase B; Provisional; Region: PRK14342 439855002189 hypothetical protein; Provisional; Region: PRK04998 439855002190 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 439855002191 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 439855002192 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 439855002193 rare lipoprotein A; Provisional; Region: PRK10672 439855002194 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 439855002195 Sporulation related domain; Region: SPOR; pfam05036 439855002196 cell wall shape-determining protein; Provisional; Region: PRK10794 439855002197 penicillin-binding protein 2; Provisional; Region: PRK10795 439855002198 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 439855002199 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 439855002200 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 439855002201 ribosome-associated protein; Provisional; Region: PRK11538 439855002202 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 439855002203 catalytic core [active] 439855002204 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 439855002205 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 439855002206 active site 439855002207 (T/H)XGH motif; other site 439855002208 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 439855002209 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 439855002210 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 439855002211 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 439855002212 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 439855002213 HIGH motif; other site 439855002214 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 439855002215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 439855002216 active site 439855002217 KMSKS motif; other site 439855002218 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 439855002219 tRNA binding surface [nucleotide binding]; other site 439855002220 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 439855002221 hypothetical protein; Provisional; Region: PRK11032 439855002222 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 439855002223 Sel1-like repeats; Region: SEL1; smart00671 439855002224 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 439855002225 Sel1-like repeats; Region: SEL1; smart00671 439855002226 Sel1-like repeats; Region: SEL1; smart00671 439855002227 Sel1-like repeats; Region: SEL1; smart00671 439855002228 Sel1-like repeats; Region: SEL1; smart00671 439855002229 Sel1-like repeats; Region: SEL1; smart00671 439855002230 Sel1-like repeats; Region: SEL1; smart00671 439855002231 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 439855002232 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 439855002233 HSP70 interaction site [polypeptide binding]; other site 439855002234 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 439855002235 Sel1-like repeats; Region: SEL1; smart00671 439855002236 Sel1-like repeats; Region: SEL1; smart00671 439855002237 Sel1-like repeats; Region: SEL1; smart00671 439855002238 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 439855002239 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 439855002240 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 439855002241 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 439855002242 nucleotide binding site [chemical binding]; other site 439855002243 putative NEF/HSP70 interaction site [polypeptide binding]; other site 439855002244 SBD interface [polypeptide binding]; other site 439855002245 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 439855002246 active site 439855002247 tetramer interface [polypeptide binding]; other site 439855002248 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 439855002249 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 439855002250 Walker A/P-loop; other site 439855002251 ATP binding site [chemical binding]; other site 439855002252 Q-loop/lid; other site 439855002253 ABC transporter signature motif; other site 439855002254 Walker B; other site 439855002255 D-loop; other site 439855002256 H-loop/switch region; other site 439855002257 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855002258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002259 dimer interface [polypeptide binding]; other site 439855002260 conserved gate region; other site 439855002261 putative PBP binding loops; other site 439855002262 ABC-ATPase subunit interface; other site 439855002263 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855002264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002265 dimer interface [polypeptide binding]; other site 439855002266 conserved gate region; other site 439855002267 putative PBP binding loops; other site 439855002268 ABC-ATPase subunit interface; other site 439855002269 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 439855002270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855002271 substrate binding pocket [chemical binding]; other site 439855002272 membrane-bound complex binding site; other site 439855002273 hinge residues; other site 439855002274 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 439855002275 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 439855002276 putative active site [active] 439855002277 catalytic triad [active] 439855002278 putative dimer interface [polypeptide binding]; other site 439855002279 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 439855002280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 439855002281 Transporter associated domain; Region: CorC_HlyC; smart01091 439855002282 metal-binding heat shock protein; Provisional; Region: PRK00016 439855002283 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 439855002284 PhoH-like protein; Region: PhoH; pfam02562 439855002285 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 439855002286 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 439855002287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855002288 FeS/SAM binding site; other site 439855002289 TRAM domain; Region: TRAM; pfam01938 439855002290 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 439855002291 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 439855002292 asparagine synthetase B; Provisional; Region: asnB; PRK09431 439855002293 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 439855002294 active site 439855002295 dimer interface [polypeptide binding]; other site 439855002296 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 439855002297 Ligand Binding Site [chemical binding]; other site 439855002298 Molecular Tunnel; other site 439855002299 UMP phosphatase; Provisional; Region: PRK10444 439855002300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002301 active site 439855002302 motif I; other site 439855002303 motif II; other site 439855002304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002305 MarR family; Region: MarR; pfam01047 439855002306 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 439855002307 ROK family; Region: ROK; pfam00480 439855002308 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 439855002309 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 439855002310 active site 439855002311 dimer interface [polypeptide binding]; other site 439855002312 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 439855002313 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 439855002314 active site 439855002315 trimer interface [polypeptide binding]; other site 439855002316 allosteric site; other site 439855002317 active site lid [active] 439855002318 hexamer (dimer of trimers) interface [polypeptide binding]; other site 439855002319 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 439855002320 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 439855002321 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855002322 active site turn [active] 439855002323 phosphorylation site [posttranslational modification] 439855002324 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 439855002325 HPr interaction site; other site 439855002326 glycerol kinase (GK) interaction site [polypeptide binding]; other site 439855002327 active site 439855002328 phosphorylation site [posttranslational modification] 439855002329 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 439855002330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 439855002331 active site 439855002332 HIGH motif; other site 439855002333 nucleotide binding site [chemical binding]; other site 439855002334 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 439855002335 KMSKS motif; other site 439855002336 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 439855002337 outer membrane porin, OprD family; Region: OprD; pfam03573 439855002338 YbfN-like lipoprotein; Region: YbfN; pfam13982 439855002339 ferric uptake regulator; Provisional; Region: fur; PRK09462 439855002340 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 439855002341 metal binding site 2 [ion binding]; metal-binding site 439855002342 putative DNA binding helix; other site 439855002343 metal binding site 1 [ion binding]; metal-binding site 439855002344 dimer interface [polypeptide binding]; other site 439855002345 structural Zn2+ binding site [ion binding]; other site 439855002346 flavodoxin FldA; Validated; Region: PRK09267 439855002347 LexA regulated protein; Provisional; Region: PRK11675 439855002348 acyl-CoA esterase; Provisional; Region: PRK10673 439855002349 PGAP1-like protein; Region: PGAP1; pfam07819 439855002350 replication initiation regulator SeqA; Provisional; Region: PRK11187 439855002351 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 439855002352 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 439855002353 active site 439855002354 substrate binding site [chemical binding]; other site 439855002355 metal binding site [ion binding]; metal-binding site 439855002356 Protein of unknown function DUF2625; Region: DUF2625; pfam10946 439855002357 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 439855002358 putrescine transporter; Provisional; Region: potE; PRK10655 439855002359 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 439855002360 ornithine decarboxylase; Provisional; Region: PRK13578 439855002361 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 439855002362 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 439855002363 homodimer interface [polypeptide binding]; other site 439855002364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855002365 catalytic residue [active] 439855002366 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 439855002367 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 439855002368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855002369 active site 439855002370 phosphorylation site [posttranslational modification] 439855002371 intermolecular recognition site; other site 439855002372 dimerization interface [polypeptide binding]; other site 439855002373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855002374 DNA binding site [nucleotide binding] 439855002375 sensor protein KdpD; Provisional; Region: PRK10490 439855002376 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 439855002377 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 439855002378 Ligand Binding Site [chemical binding]; other site 439855002379 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 439855002380 GAF domain; Region: GAF_3; pfam13492 439855002381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855002382 dimer interface [polypeptide binding]; other site 439855002383 phosphorylation site [posttranslational modification] 439855002384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855002385 ATP binding site [chemical binding]; other site 439855002386 Mg2+ binding site [ion binding]; other site 439855002387 G-X-G motif; other site 439855002388 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 439855002389 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 439855002390 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 439855002391 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 439855002392 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 439855002393 hypothetical protein; Provisional; Region: PRK10167 439855002394 Uncharacterized conserved protein [Function unknown]; Region: COG3272 439855002395 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 439855002396 DNA photolyase; Region: DNA_photolyase; pfam00875 439855002397 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 439855002398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855002399 putative substrate translocation pore; other site 439855002400 POT family; Region: PTR2; pfam00854 439855002401 Uncharacterized conserved protein [Function unknown]; Region: COG0327 439855002402 metal-binding protein; Provisional; Region: PRK10799 439855002403 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 439855002404 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 439855002405 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 439855002406 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 439855002407 putative active site [active] 439855002408 endonuclease VIII; Provisional; Region: PRK10445 439855002409 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 439855002410 DNA binding site [nucleotide binding] 439855002411 catalytic residue [active] 439855002412 putative catalytic residues [active] 439855002413 H2TH interface [polypeptide binding]; other site 439855002414 intercalation triad [nucleotide binding]; other site 439855002415 substrate specificity determining residue; other site 439855002416 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 439855002417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 439855002418 Putative ammonia monooxygenase; Region: AmoA; pfam05145 439855002419 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 439855002420 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 439855002421 Fimbrial protein; Region: Fimbrial; pfam00419 439855002422 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 439855002423 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 439855002424 dimer interface [polypeptide binding]; other site 439855002425 active site 439855002426 citrylCoA binding site [chemical binding]; other site 439855002427 NADH binding [chemical binding]; other site 439855002428 cationic pore residues; other site 439855002429 oxalacetate/citrate binding site [chemical binding]; other site 439855002430 coenzyme A binding site [chemical binding]; other site 439855002431 catalytic triad [active] 439855002432 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 439855002433 Iron-sulfur protein interface; other site 439855002434 proximal quinone binding site [chemical binding]; other site 439855002435 SdhD (CybS) interface [polypeptide binding]; other site 439855002436 proximal heme binding site [chemical binding]; other site 439855002437 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 439855002438 SdhC subunit interface [polypeptide binding]; other site 439855002439 proximal heme binding site [chemical binding]; other site 439855002440 cardiolipin binding site; other site 439855002441 Iron-sulfur protein interface; other site 439855002442 proximal quinone binding site [chemical binding]; other site 439855002443 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 439855002444 L-aspartate oxidase; Provisional; Region: PRK06175 439855002445 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 439855002446 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 439855002447 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 439855002448 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 439855002449 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 439855002450 TPP-binding site [chemical binding]; other site 439855002451 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 439855002452 dimer interface [polypeptide binding]; other site 439855002453 PYR/PP interface [polypeptide binding]; other site 439855002454 TPP binding site [chemical binding]; other site 439855002455 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 439855002456 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 439855002457 E3 interaction surface; other site 439855002458 lipoyl attachment site [posttranslational modification]; other site 439855002459 e3 binding domain; Region: E3_binding; pfam02817 439855002460 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 439855002461 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 439855002462 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 439855002463 CoA-ligase; Region: Ligase_CoA; pfam00549 439855002464 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 439855002465 CoA binding domain; Region: CoA_binding; smart00881 439855002466 CoA-ligase; Region: Ligase_CoA; pfam00549 439855002467 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 439855002468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855002469 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 439855002470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855002471 dimerization interface [polypeptide binding]; other site 439855002472 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 439855002473 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 439855002474 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 439855002475 homodimer interface [polypeptide binding]; other site 439855002476 Walker A motif; other site 439855002477 ATP binding site [chemical binding]; other site 439855002478 hydroxycobalamin binding site [chemical binding]; other site 439855002479 Walker B motif; other site 439855002480 putative fumarate hydratase; Provisional; Region: PRK15392 439855002481 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 439855002482 Fumarase C-terminus; Region: Fumerase_C; pfam05683 439855002483 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 439855002484 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 439855002485 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 439855002486 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 439855002487 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 439855002488 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 439855002489 dimer interface [polypeptide binding]; other site 439855002490 active site 439855002491 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 439855002492 substrate binding site [chemical binding]; other site 439855002493 B12 cofactor binding site [chemical binding]; other site 439855002494 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 439855002495 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 439855002496 conserved hypothetical protein; Region: glmL_fam; TIGR01319 439855002497 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 439855002498 B12 binding site [chemical binding]; other site 439855002499 heterodimer interface [polypeptide binding]; other site 439855002500 cobalt ligand [ion binding]; other site 439855002501 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 439855002502 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 439855002503 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 439855002504 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 439855002505 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 439855002506 hypothetical protein; Provisional; Region: PRK10588 439855002507 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 439855002508 active site 439855002509 colicin uptake protein TolQ; Provisional; Region: PRK10801 439855002510 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 439855002511 colicin uptake protein TolR; Provisional; Region: PRK11024 439855002512 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 439855002513 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 439855002514 TolA C-terminal; Region: TolA; pfam06519 439855002515 translocation protein TolB; Provisional; Region: tolB; PRK03629 439855002516 TolB amino-terminal domain; Region: TolB_N; pfam04052 439855002517 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 439855002518 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 439855002519 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 439855002520 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 439855002521 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855002522 ligand binding site [chemical binding]; other site 439855002523 tol-pal system protein YbgF; Provisional; Region: PRK10803 439855002524 Tetratricopeptide repeat; Region: TPR_6; pfam13174 439855002525 Tetratricopeptide repeat; Region: TPR_6; pfam13174 439855002526 quinolinate synthetase; Provisional; Region: PRK09375 439855002527 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 439855002528 YbgS-like protein; Region: YbgS; pfam13985 439855002529 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 439855002530 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 439855002531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 439855002532 catalytic core [active] 439855002533 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 439855002534 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 439855002535 active site 439855002536 catalytic residues [active] 439855002537 galactokinase; Provisional; Region: PRK05101 439855002538 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 439855002539 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 439855002540 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 439855002541 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 439855002542 dimer interface [polypeptide binding]; other site 439855002543 active site 439855002544 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 439855002545 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 439855002546 NAD binding site [chemical binding]; other site 439855002547 homodimer interface [polypeptide binding]; other site 439855002548 active site 439855002549 substrate binding site [chemical binding]; other site 439855002550 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 439855002551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 439855002552 Walker A/P-loop; other site 439855002553 ATP binding site [chemical binding]; other site 439855002554 Q-loop/lid; other site 439855002555 ABC transporter signature motif; other site 439855002556 Walker B; other site 439855002557 D-loop; other site 439855002558 H-loop/switch region; other site 439855002559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855002560 Walker A/P-loop; other site 439855002561 ATP binding site [chemical binding]; other site 439855002562 Q-loop/lid; other site 439855002563 ABC transporter signature motif; other site 439855002564 Walker B; other site 439855002565 D-loop; other site 439855002566 H-loop/switch region; other site 439855002567 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 439855002568 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 439855002569 molybdenum-pterin binding domain; Region: Mop; TIGR00638 439855002570 TOBE domain; Region: TOBE; pfam03459 439855002571 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 439855002572 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 439855002573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855002574 substrate binding pocket [chemical binding]; other site 439855002575 membrane-bound complex binding site; other site 439855002576 hinge residues; other site 439855002577 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 439855002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002579 dimer interface [polypeptide binding]; other site 439855002580 conserved gate region; other site 439855002581 putative PBP binding loops; other site 439855002582 ABC-ATPase subunit interface; other site 439855002583 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 439855002584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855002585 Walker A/P-loop; other site 439855002586 ATP binding site [chemical binding]; other site 439855002587 Q-loop/lid; other site 439855002588 ABC transporter signature motif; other site 439855002589 Walker B; other site 439855002590 D-loop; other site 439855002591 H-loop/switch region; other site 439855002592 molybdenum-pterin binding domain; Region: Mop; TIGR00638 439855002593 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 439855002594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002595 motif II; other site 439855002596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002597 6-phosphogluconolactonase; Provisional; Region: PRK11028 439855002598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855002599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855002600 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 439855002601 putative dimerization interface [polypeptide binding]; other site 439855002602 PrpF protein; Region: PrpF; pfam04303 439855002603 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 439855002604 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 439855002605 transmembrane helices; other site 439855002606 putative hydratase; Provisional; Region: PRK11413 439855002607 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 439855002608 substrate binding site [chemical binding]; other site 439855002609 ligand binding site [chemical binding]; other site 439855002610 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 439855002611 substrate binding site [chemical binding]; other site 439855002612 acyl-CoA thioesterase; Provisional; Region: PRK10531 439855002613 putative pectinesterase; Region: PLN02432; cl01911 439855002614 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 439855002615 substrate binding site [chemical binding]; other site 439855002616 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 439855002617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855002618 inhibitor-cofactor binding pocket; inhibition site 439855002619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855002620 catalytic residue [active] 439855002621 biotin synthase; Provisional; Region: PRK15108 439855002622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855002623 FeS/SAM binding site; other site 439855002624 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 439855002625 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 439855002626 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 439855002627 substrate-cofactor binding pocket; other site 439855002628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855002629 catalytic residue [active] 439855002630 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 439855002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855002632 S-adenosylmethionine binding site [chemical binding]; other site 439855002633 AAA domain; Region: AAA_26; pfam13500 439855002634 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 439855002635 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 439855002636 ADP binding site [chemical binding]; other site 439855002637 excinuclease ABC subunit B; Provisional; Region: PRK05298 439855002638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855002639 ATP binding site [chemical binding]; other site 439855002640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855002641 nucleotide binding region [chemical binding]; other site 439855002642 ATP-binding site [chemical binding]; other site 439855002643 Ultra-violet resistance protein B; Region: UvrB; pfam12344 439855002644 UvrB/uvrC motif; Region: UVR; pfam02151 439855002645 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 439855002646 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 439855002647 putative substrate binding pocket [chemical binding]; other site 439855002648 dimer interface [polypeptide binding]; other site 439855002649 phosphate binding site [ion binding]; other site 439855002650 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 439855002651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855002652 FeS/SAM binding site; other site 439855002653 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 439855002654 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 439855002655 MPT binding site; other site 439855002656 trimer interface [polypeptide binding]; other site 439855002657 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 439855002658 trimer interface [polypeptide binding]; other site 439855002659 dimer interface [polypeptide binding]; other site 439855002660 putative active site [active] 439855002661 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 439855002662 MoaE interaction surface [polypeptide binding]; other site 439855002663 MoeB interaction surface [polypeptide binding]; other site 439855002664 thiocarboxylated glycine; other site 439855002665 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 439855002666 MoaE homodimer interface [polypeptide binding]; other site 439855002667 MoaD interaction [polypeptide binding]; other site 439855002668 active site residues [active] 439855002669 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 439855002670 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 439855002671 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 439855002672 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 439855002673 Predicted integral membrane protein [Function unknown]; Region: COG0392 439855002674 cardiolipin synthase 2; Provisional; Region: PRK11263 439855002675 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 439855002676 putative active site [active] 439855002677 catalytic site [active] 439855002678 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 439855002679 putative active site [active] 439855002680 catalytic site [active] 439855002681 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 439855002682 putative catalytic site [active] 439855002683 putative metal binding site [ion binding]; other site 439855002684 putative phosphate binding site [ion binding]; other site 439855002685 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 439855002686 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 439855002687 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 439855002688 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 439855002689 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 439855002690 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 439855002691 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 439855002692 Walker A/P-loop; other site 439855002693 ATP binding site [chemical binding]; other site 439855002694 Q-loop/lid; other site 439855002695 ABC transporter signature motif; other site 439855002696 Walker B; other site 439855002697 D-loop; other site 439855002698 H-loop/switch region; other site 439855002699 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 439855002700 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 439855002701 Walker A/P-loop; other site 439855002702 ATP binding site [chemical binding]; other site 439855002703 Q-loop/lid; other site 439855002704 ABC transporter signature motif; other site 439855002705 Walker B; other site 439855002706 D-loop; other site 439855002707 H-loop/switch region; other site 439855002708 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 439855002709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855002710 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855002711 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 439855002712 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 439855002713 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 439855002714 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 439855002715 ATP binding site [chemical binding]; other site 439855002716 Mg++ binding site [ion binding]; other site 439855002717 motif III; other site 439855002718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855002719 nucleotide binding region [chemical binding]; other site 439855002720 ATP-binding site [chemical binding]; other site 439855002721 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 439855002722 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 439855002723 DEAD_2; Region: DEAD_2; pfam06733 439855002724 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 439855002725 glycosyl transferase family protein; Provisional; Region: PRK08136 439855002726 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 439855002727 putative dehydrogenase; Provisional; Region: PRK10098 439855002728 hypothetical protein; Provisional; Region: PRK10259 439855002729 hypothetical protein; Provisional; Region: PRK11019 439855002730 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 439855002731 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 439855002732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855002733 N-terminal plug; other site 439855002734 ligand-binding site [chemical binding]; other site 439855002735 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855002736 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 439855002737 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 439855002738 putative mechanosensitive channel protein; Provisional; Region: PRK11465 439855002739 Mechanosensitive ion channel; Region: MS_channel; pfam00924 439855002740 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 439855002741 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 439855002742 Walker A/P-loop; other site 439855002743 ATP binding site [chemical binding]; other site 439855002744 Q-loop/lid; other site 439855002745 ABC transporter signature motif; other site 439855002746 Walker B; other site 439855002747 D-loop; other site 439855002748 H-loop/switch region; other site 439855002749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855002750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002751 dimer interface [polypeptide binding]; other site 439855002752 conserved gate region; other site 439855002753 putative PBP binding loops; other site 439855002754 ABC-ATPase subunit interface; other site 439855002755 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 439855002756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855002757 substrate binding pocket [chemical binding]; other site 439855002758 membrane-bound complex binding site; other site 439855002759 hinge residues; other site 439855002760 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 439855002761 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 439855002762 dimerization interface [polypeptide binding]; other site 439855002763 DPS ferroxidase diiron center [ion binding]; other site 439855002764 ion pore; other site 439855002765 threonine and homoserine efflux system; Provisional; Region: PRK10532 439855002766 EamA-like transporter family; Region: EamA; pfam00892 439855002767 outer membrane protein X; Provisional; Region: ompX; PRK09408 439855002768 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 439855002769 Sulfatase; Region: Sulfatase; pfam00884 439855002770 manganese transport regulator MntR; Provisional; Region: PRK11050 439855002771 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 439855002772 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 439855002773 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 439855002774 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 439855002775 transmembrane helices; other site 439855002776 L,D-transpeptidase; Provisional; Region: PRK10260 439855002777 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855002778 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 439855002779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855002780 Walker A/P-loop; other site 439855002781 ATP binding site [chemical binding]; other site 439855002782 Q-loop/lid; other site 439855002783 ABC transporter signature motif; other site 439855002784 Walker B; other site 439855002785 D-loop; other site 439855002786 H-loop/switch region; other site 439855002787 ABC transporter; Region: ABC_tran_2; pfam12848 439855002788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 439855002789 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 439855002790 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 439855002791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002792 active site 439855002793 motif I; other site 439855002794 motif II; other site 439855002795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002796 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 439855002797 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 439855002798 dimer interface [polypeptide binding]; other site 439855002799 active site 439855002800 glycine loop; other site 439855002801 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 439855002802 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 439855002803 active site 439855002804 intersubunit interactions; other site 439855002805 catalytic residue [active] 439855002806 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 439855002807 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 439855002808 ATP binding site [chemical binding]; other site 439855002809 substrate interface [chemical binding]; other site 439855002810 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 439855002811 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 439855002812 dimer interface [polypeptide binding]; other site 439855002813 putative functional site; other site 439855002814 putative MPT binding site; other site 439855002815 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 439855002816 catalytic nucleophile [active] 439855002817 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 439855002818 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855002819 Walker A/P-loop; other site 439855002820 ATP binding site [chemical binding]; other site 439855002821 Q-loop/lid; other site 439855002822 ABC transporter signature motif; other site 439855002823 Walker B; other site 439855002824 D-loop; other site 439855002825 H-loop/switch region; other site 439855002826 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 439855002827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855002828 Walker A/P-loop; other site 439855002829 ATP binding site [chemical binding]; other site 439855002830 Q-loop/lid; other site 439855002831 ABC transporter signature motif; other site 439855002832 Walker B; other site 439855002833 D-loop; other site 439855002834 H-loop/switch region; other site 439855002835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 439855002836 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 439855002837 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 439855002838 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 439855002839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002840 dimer interface [polypeptide binding]; other site 439855002841 conserved gate region; other site 439855002842 putative PBP binding loops; other site 439855002843 ABC-ATPase subunit interface; other site 439855002844 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 439855002845 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 439855002846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002847 dimer interface [polypeptide binding]; other site 439855002848 conserved gate region; other site 439855002849 putative PBP binding loops; other site 439855002850 ABC-ATPase subunit interface; other site 439855002851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855002852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855002853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855002854 metal binding site [ion binding]; metal-binding site 439855002855 active site 439855002856 I-site; other site 439855002857 Predicted transcriptional regulator [Transcription]; Region: COG2944 439855002858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855002859 non-specific DNA binding site [nucleotide binding]; other site 439855002860 salt bridge; other site 439855002861 sequence-specific DNA binding site [nucleotide binding]; other site 439855002862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 439855002863 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 439855002864 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 439855002865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855002866 FeS/SAM binding site; other site 439855002867 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 439855002868 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 439855002869 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 439855002870 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 439855002871 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 439855002872 putative C-terminal domain interface [polypeptide binding]; other site 439855002873 putative GSH binding site (G-site) [chemical binding]; other site 439855002874 putative dimer interface [polypeptide binding]; other site 439855002875 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 439855002876 N-terminal domain interface [polypeptide binding]; other site 439855002877 dimer interface [polypeptide binding]; other site 439855002878 substrate binding pocket (H-site) [chemical binding]; other site 439855002879 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 439855002880 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 439855002881 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 439855002882 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 439855002883 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 439855002884 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855002885 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 439855002886 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 439855002887 active site 439855002888 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 439855002889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855002890 putative substrate translocation pore; other site 439855002891 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 439855002892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002893 active site 439855002894 motif I; other site 439855002895 motif II; other site 439855002896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855002897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855002898 putative substrate translocation pore; other site 439855002899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855002900 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 439855002901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855002902 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 439855002903 putative transporter; Provisional; Region: PRK04972 439855002904 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 439855002905 TrkA-C domain; Region: TrkA_C; pfam02080 439855002906 TrkA-C domain; Region: TrkA_C; pfam02080 439855002907 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 439855002908 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 439855002909 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 439855002910 GSH binding site [chemical binding]; other site 439855002911 catalytic residues [active] 439855002912 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 439855002913 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 439855002914 dimer interface [polypeptide binding]; other site 439855002915 FMN binding site [chemical binding]; other site 439855002916 NADPH bind site [chemical binding]; other site 439855002917 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 439855002918 RimK-like ATP-grasp domain; Region: RimK; pfam08443 439855002919 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 439855002920 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 439855002921 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 439855002922 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 439855002923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855002924 Walker A/P-loop; other site 439855002925 ATP binding site [chemical binding]; other site 439855002926 Q-loop/lid; other site 439855002927 ABC transporter signature motif; other site 439855002928 Walker B; other site 439855002929 D-loop; other site 439855002930 H-loop/switch region; other site 439855002931 TOBE domain; Region: TOBE_2; pfam08402 439855002932 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 439855002933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002934 dimer interface [polypeptide binding]; other site 439855002935 conserved gate region; other site 439855002936 putative PBP binding loops; other site 439855002937 ABC-ATPase subunit interface; other site 439855002938 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 439855002939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002940 dimer interface [polypeptide binding]; other site 439855002941 conserved gate region; other site 439855002942 putative PBP binding loops; other site 439855002943 ABC-ATPase subunit interface; other site 439855002944 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 439855002945 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 439855002946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855002947 S-adenosylmethionine binding site [chemical binding]; other site 439855002948 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 439855002949 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855002950 substrate binding pocket [chemical binding]; other site 439855002951 membrane-bound complex binding site; other site 439855002952 hinge residues; other site 439855002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002954 dimer interface [polypeptide binding]; other site 439855002955 conserved gate region; other site 439855002956 putative PBP binding loops; other site 439855002957 ABC-ATPase subunit interface; other site 439855002958 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855002959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855002960 dimer interface [polypeptide binding]; other site 439855002961 conserved gate region; other site 439855002962 putative PBP binding loops; other site 439855002963 ABC-ATPase subunit interface; other site 439855002964 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 439855002965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855002966 substrate binding pocket [chemical binding]; other site 439855002967 membrane-bound complex binding site; other site 439855002968 hinge residues; other site 439855002969 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 439855002970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855002971 Walker A/P-loop; other site 439855002972 ATP binding site [chemical binding]; other site 439855002973 Q-loop/lid; other site 439855002974 ABC transporter signature motif; other site 439855002975 Walker B; other site 439855002976 D-loop; other site 439855002977 H-loop/switch region; other site 439855002978 putative lipoprotein; Provisional; Region: PRK10533 439855002979 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 439855002980 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 439855002981 hypothetical protein; Provisional; Region: PRK02877 439855002982 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 439855002983 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 439855002984 amidase catalytic site [active] 439855002985 Zn binding residues [ion binding]; other site 439855002986 substrate binding site [chemical binding]; other site 439855002987 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 439855002988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 439855002989 NAD(P) binding site [chemical binding]; other site 439855002990 active site 439855002991 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 439855002992 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 439855002993 putative NAD(P) binding site [chemical binding]; other site 439855002994 putative active site [active] 439855002995 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 439855002996 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 439855002997 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 439855002998 tetramer interface [polypeptide binding]; other site 439855002999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855003000 catalytic residue [active] 439855003001 pyruvate dehydrogenase; Provisional; Region: PRK09124 439855003002 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 439855003003 PYR/PP interface [polypeptide binding]; other site 439855003004 dimer interface [polypeptide binding]; other site 439855003005 tetramer interface [polypeptide binding]; other site 439855003006 TPP binding site [chemical binding]; other site 439855003007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855003008 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 439855003009 TPP-binding site [chemical binding]; other site 439855003010 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 439855003011 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 439855003012 FAD binding pocket [chemical binding]; other site 439855003013 FAD binding motif [chemical binding]; other site 439855003014 phosphate binding motif [ion binding]; other site 439855003015 beta-alpha-beta structure motif; other site 439855003016 NAD binding pocket [chemical binding]; other site 439855003017 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855003018 catalytic loop [active] 439855003019 iron binding site [ion binding]; other site 439855003020 hybrid cluster protein; Provisional; Region: PRK05290 439855003021 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855003022 ACS interaction site; other site 439855003023 CODH interaction site; other site 439855003024 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 439855003025 hybrid metal cluster; other site 439855003026 Predicted membrane protein [Function unknown]; Region: COG2431 439855003027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 439855003028 Transposase; Region: DEDD_Tnp_IS110; pfam01548 439855003029 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 439855003030 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 439855003031 oxidoreductase; Provisional; Region: PRK12743 439855003032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 439855003033 NAD(P) binding site [chemical binding]; other site 439855003034 active site 439855003035 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 439855003036 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 439855003037 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 439855003038 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 439855003039 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 439855003040 D-lactate dehydrogenase; Provisional; Region: PRK11183 439855003041 FAD binding domain; Region: FAD_binding_4; pfam01565 439855003042 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 439855003043 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 439855003044 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 439855003045 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 439855003046 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 439855003047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855003048 dimer interface [polypeptide binding]; other site 439855003049 conserved gate region; other site 439855003050 ABC-ATPase subunit interface; other site 439855003051 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 439855003052 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 439855003053 Walker A/P-loop; other site 439855003054 ATP binding site [chemical binding]; other site 439855003055 Q-loop/lid; other site 439855003056 ABC transporter signature motif; other site 439855003057 Walker B; other site 439855003058 D-loop; other site 439855003059 H-loop/switch region; other site 439855003060 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 439855003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855003062 putative PBP binding loops; other site 439855003063 ABC-ATPase subunit interface; other site 439855003064 transcriptional regulator MirA; Provisional; Region: PRK15043 439855003065 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 439855003066 DNA binding residues [nucleotide binding] 439855003067 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 439855003068 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 439855003069 GAF domain; Region: GAF; pfam01590 439855003070 Histidine kinase; Region: His_kinase; pfam06580 439855003071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855003072 ATP binding site [chemical binding]; other site 439855003073 Mg2+ binding site [ion binding]; other site 439855003074 G-X-G motif; other site 439855003075 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 439855003076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855003077 active site 439855003078 phosphorylation site [posttranslational modification] 439855003079 intermolecular recognition site; other site 439855003080 dimerization interface [polypeptide binding]; other site 439855003081 LytTr DNA-binding domain; Region: LytTR; pfam04397 439855003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 439855003083 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 439855003084 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 439855003085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 439855003086 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 439855003087 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 439855003088 metal ion-dependent adhesion site (MIDAS); other site 439855003089 MoxR-like ATPases [General function prediction only]; Region: COG0714 439855003090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855003091 Walker A motif; other site 439855003092 ATP binding site [chemical binding]; other site 439855003093 Walker B motif; other site 439855003094 arginine finger; other site 439855003095 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 439855003096 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 439855003097 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 439855003098 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 439855003099 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 439855003100 active site 439855003101 HIGH motif; other site 439855003102 KMSKS motif; other site 439855003103 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 439855003104 tRNA binding surface [nucleotide binding]; other site 439855003105 anticodon binding site; other site 439855003106 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 439855003107 dimer interface [polypeptide binding]; other site 439855003108 putative tRNA-binding site [nucleotide binding]; other site 439855003109 antiporter inner membrane protein; Provisional; Region: PRK11670 439855003110 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 439855003111 Walker A motif; other site 439855003112 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 439855003113 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855003114 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 439855003115 PapC N-terminal domain; Region: PapC_N; pfam13954 439855003116 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855003117 PapC C-terminal domain; Region: PapC_C; pfam13953 439855003118 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 439855003119 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 439855003120 Predicted integral membrane protein [Function unknown]; Region: COG5455 439855003121 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 439855003122 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 439855003123 putative metal binding site [ion binding]; other site 439855003124 putative homodimer interface [polypeptide binding]; other site 439855003125 putative homotetramer interface [polypeptide binding]; other site 439855003126 putative homodimer-homodimer interface [polypeptide binding]; other site 439855003127 putative allosteric switch controlling residues; other site 439855003128 integrase; Provisional; Region: PRK09692 439855003129 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 439855003130 active site 439855003131 Int/Topo IB signature motif; other site 439855003132 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 439855003133 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 439855003134 D5 N terminal like; Region: D5_N; smart00885 439855003135 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 439855003136 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 439855003137 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 439855003138 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 439855003139 ssDNA binding site [nucleotide binding]; other site 439855003140 dimer interface [polypeptide binding]; other site 439855003141 tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855003142 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 439855003143 Phage capsid family; Region: Phage_capsid; pfam05065 439855003144 Phage head maturation protease [General function prediction only]; Region: COG3740 439855003145 Phage-related protein [Function unknown]; Region: COG4695 439855003146 Phage portal protein; Region: Phage_portal; pfam04860 439855003147 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 439855003148 oligomerization interface [polypeptide binding]; other site 439855003149 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 439855003150 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 439855003151 active site 439855003152 Phage terminase, small subunit; Region: Terminase_4; cl01525 439855003153 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 439855003154 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 439855003155 substrate binding site [chemical binding]; other site 439855003156 multimerization interface [polypeptide binding]; other site 439855003157 ATP binding site [chemical binding]; other site 439855003158 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 439855003159 dimer interface [polypeptide binding]; other site 439855003160 substrate binding site [chemical binding]; other site 439855003161 ATP binding site [chemical binding]; other site 439855003162 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 439855003163 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 439855003164 active site 439855003165 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 439855003166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855003167 DNA-binding site [nucleotide binding]; DNA binding site 439855003168 UTRA domain; Region: UTRA; pfam07702 439855003169 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855003170 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 439855003171 substrate binding site [chemical binding]; other site 439855003172 ATP binding site [chemical binding]; other site 439855003173 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 439855003174 nucleoside transporter; Region: 2A0110; TIGR00889 439855003175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855003176 putative substrate translocation pore; other site 439855003177 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 439855003178 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 439855003179 putative active site; other site 439855003180 catalytic residue [active] 439855003181 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 439855003182 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 439855003183 intersubunit interface [polypeptide binding]; other site 439855003184 active site 439855003185 zinc binding site [ion binding]; other site 439855003186 Na+ binding site [ion binding]; other site 439855003187 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 439855003188 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855003189 active site 439855003190 phosphorylation site [posttranslational modification] 439855003191 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 439855003192 active site 439855003193 P-loop; other site 439855003194 phosphorylation site [posttranslational modification] 439855003195 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 439855003196 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 439855003197 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 439855003198 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 439855003199 putative NAD(P) binding site [chemical binding]; other site 439855003200 catalytic Zn binding site [ion binding]; other site 439855003201 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 439855003202 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 439855003203 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855003204 lipid kinase; Reviewed; Region: PRK13054 439855003205 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 439855003206 putative protease; Provisional; Region: PRK15452 439855003207 Peptidase family U32; Region: Peptidase_U32; pfam01136 439855003208 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 439855003209 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 439855003210 Uncharacterized conserved protein [Function unknown]; Region: COG3422 439855003211 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 439855003212 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 439855003213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855003214 active site 439855003215 phosphorylation site [posttranslational modification] 439855003216 intermolecular recognition site; other site 439855003217 dimerization interface [polypeptide binding]; other site 439855003218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855003219 DNA binding site [nucleotide binding] 439855003220 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 439855003221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855003222 dimerization interface [polypeptide binding]; other site 439855003223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855003224 dimer interface [polypeptide binding]; other site 439855003225 phosphorylation site [posttranslational modification] 439855003226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855003227 ATP binding site [chemical binding]; other site 439855003228 Mg2+ binding site [ion binding]; other site 439855003229 G-X-G motif; other site 439855003230 putative transporter; Provisional; Region: PRK10504 439855003231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855003232 putative substrate translocation pore; other site 439855003233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855003234 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 439855003235 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 439855003236 Protein export membrane protein; Region: SecD_SecF; cl14618 439855003237 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 439855003238 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855003239 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855003240 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 439855003241 metal ion-dependent adhesion site (MIDAS); other site 439855003242 Protein phosphatase 2C; Region: PP2C_2; pfam13672 439855003243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 439855003244 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 439855003245 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 439855003246 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 439855003247 substrate binding site [chemical binding]; other site 439855003248 activation loop (A-loop); other site 439855003249 Y-family of DNA polymerases; Region: PolY; cl12025 439855003250 putative chaperone; Provisional; Region: PRK11678 439855003251 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 439855003252 nucleotide binding site [chemical binding]; other site 439855003253 putative NEF/HSP70 interaction site [polypeptide binding]; other site 439855003254 SBD interface [polypeptide binding]; other site 439855003255 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 439855003256 AlkA N-terminal domain; Region: AlkA_N; smart01009 439855003257 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 439855003258 minor groove reading motif; other site 439855003259 helix-hairpin-helix signature motif; other site 439855003260 substrate binding pocket [chemical binding]; other site 439855003261 active site 439855003262 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 439855003263 putative diguanylate cyclase; Provisional; Region: PRK09776 439855003264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855003265 putative active site [active] 439855003266 heme pocket [chemical binding]; other site 439855003267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855003268 putative active site [active] 439855003269 heme pocket [chemical binding]; other site 439855003270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855003271 putative active site [active] 439855003272 heme pocket [chemical binding]; other site 439855003273 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855003274 metal binding site [ion binding]; metal-binding site 439855003275 active site 439855003276 I-site; other site 439855003277 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 439855003278 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 439855003279 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 439855003280 ATP-binding site [chemical binding]; other site 439855003281 Sugar specificity; other site 439855003282 Pyrimidine base specificity; other site 439855003283 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 439855003284 trimer interface [polypeptide binding]; other site 439855003285 active site 439855003286 putative assembly protein; Provisional; Region: PRK10833 439855003287 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 439855003288 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 439855003289 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 439855003290 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 439855003291 FOG: CBS domain [General function prediction only]; Region: COG0517 439855003292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 439855003293 Transporter associated domain; Region: CorC_HlyC; smart01091 439855003294 polysaccharide export protein Wza; Provisional; Region: PRK15078 439855003295 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 439855003296 SLBB domain; Region: SLBB; pfam10531 439855003297 Low molecular weight phosphatase family; Region: LMWPc; cd00115 439855003298 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 439855003299 active site 439855003300 tyrosine kinase; Provisional; Region: PRK11519 439855003301 Chain length determinant protein; Region: Wzz; pfam02706 439855003302 Chain length determinant protein; Region: Wzz; cl15801 439855003303 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 439855003304 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 439855003305 putative glycosyl transferase; Provisional; Region: PRK10018 439855003306 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 439855003307 active site 439855003308 putative acyl transferase; Provisional; Region: PRK10191 439855003309 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 439855003310 trimer interface [polypeptide binding]; other site 439855003311 active site 439855003312 substrate binding site [chemical binding]; other site 439855003313 CoA binding site [chemical binding]; other site 439855003314 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 439855003315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 439855003316 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 439855003317 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 439855003318 putative glycosyl transferase; Provisional; Region: PRK10063 439855003319 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 439855003320 metal-binding site 439855003321 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 439855003322 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 439855003323 putative trimer interface [polypeptide binding]; other site 439855003324 putative active site [active] 439855003325 putative substrate binding site [chemical binding]; other site 439855003326 putative CoA binding site [chemical binding]; other site 439855003327 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 439855003328 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 439855003329 NADP-binding site; other site 439855003330 homotetramer interface [polypeptide binding]; other site 439855003331 substrate binding site [chemical binding]; other site 439855003332 homodimer interface [polypeptide binding]; other site 439855003333 active site 439855003334 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 439855003335 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 439855003336 NADP binding site [chemical binding]; other site 439855003337 active site 439855003338 putative substrate binding site [chemical binding]; other site 439855003339 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 439855003340 active site 439855003341 GDP-Mannose binding site [chemical binding]; other site 439855003342 dimer interface [polypeptide binding]; other site 439855003343 modified nudix motif 439855003344 metal binding site [ion binding]; metal-binding site 439855003345 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 439855003346 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 439855003347 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 439855003348 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 439855003349 Substrate binding site; other site 439855003350 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 439855003351 phosphomannomutase CpsG; Provisional; Region: PRK15414 439855003352 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 439855003353 active site 439855003354 substrate binding site [chemical binding]; other site 439855003355 metal binding site [ion binding]; metal-binding site 439855003356 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 439855003357 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 439855003358 colanic acid exporter; Provisional; Region: PRK10459 439855003359 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 439855003360 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 439855003361 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 439855003362 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 439855003363 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 439855003364 putative ADP-binding pocket [chemical binding]; other site 439855003365 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 439855003366 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 439855003367 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 439855003368 putative NAD(P) binding site [chemical binding]; other site 439855003369 active site 439855003370 putative substrate binding site [chemical binding]; other site 439855003371 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 439855003372 active site 439855003373 tetramer interface; other site 439855003374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 439855003375 active site 439855003376 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 439855003377 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 439855003378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 439855003379 active site 439855003380 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 439855003381 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 439855003382 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 439855003383 phosphoglycerol transferase I; Provisional; Region: PRK12363 439855003384 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855003385 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 439855003386 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 439855003387 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 439855003388 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 439855003389 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 439855003390 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 439855003391 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 439855003392 chain length determinant protein WzzB; Provisional; Region: PRK15471 439855003393 Chain length determinant protein; Region: Wzz; pfam02706 439855003394 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 439855003395 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 439855003396 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 439855003397 metal binding site [ion binding]; metal-binding site 439855003398 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 439855003399 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 439855003400 substrate binding site [chemical binding]; other site 439855003401 glutamase interaction surface [polypeptide binding]; other site 439855003402 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 439855003403 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 439855003404 catalytic residues [active] 439855003405 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 439855003406 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 439855003407 putative active site [active] 439855003408 oxyanion strand; other site 439855003409 catalytic triad [active] 439855003410 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 439855003411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855003412 active site 439855003413 motif I; other site 439855003414 motif II; other site 439855003415 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 439855003416 putative active site pocket [active] 439855003417 4-fold oligomerization interface [polypeptide binding]; other site 439855003418 metal binding residues [ion binding]; metal-binding site 439855003419 3-fold/trimer interface [polypeptide binding]; other site 439855003420 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 439855003421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855003422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855003423 homodimer interface [polypeptide binding]; other site 439855003424 catalytic residue [active] 439855003425 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 439855003426 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 439855003427 NAD binding site [chemical binding]; other site 439855003428 dimerization interface [polypeptide binding]; other site 439855003429 product binding site; other site 439855003430 substrate binding site [chemical binding]; other site 439855003431 zinc binding site [ion binding]; other site 439855003432 catalytic residues [active] 439855003433 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 439855003434 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 439855003435 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 439855003436 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 439855003437 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 439855003438 putative NAD(P) binding site [chemical binding]; other site 439855003439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855003440 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 439855003441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855003442 dimerization interface [polypeptide binding]; other site 439855003443 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 439855003444 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 439855003445 Sulphur transport; Region: Sulf_transp; pfam04143 439855003446 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 439855003447 CPxP motif; other site 439855003448 exonuclease I; Provisional; Region: sbcB; PRK11779 439855003449 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 439855003450 active site 439855003451 catalytic site [active] 439855003452 substrate binding site [chemical binding]; other site 439855003453 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 439855003454 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 439855003455 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 439855003456 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 439855003457 DNA gyrase inhibitor; Provisional; Region: PRK10016 439855003458 Predicted membrane protein [Function unknown]; Region: COG1289 439855003459 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 439855003460 hypothetical protein; Provisional; Region: PRK05423 439855003461 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 439855003462 Switch II region; other site 439855003463 G4 box; other site 439855003464 G5 box; other site 439855003465 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 439855003466 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 439855003467 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 439855003468 Protein of unknown function (DUF987); Region: DUF987; pfam06174 439855003469 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 439855003470 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 439855003471 MPN+ (JAMM) motif; other site 439855003472 Zinc-binding site [ion binding]; other site 439855003473 Antirestriction protein; Region: Antirestrict; pfam03230 439855003474 Domain of unknown function (DUF932); Region: DUF932; pfam06067 439855003475 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 439855003476 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 439855003477 nucleophile elbow; other site 439855003478 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 439855003479 YjcZ-like protein; Region: YjcZ; pfam13990 439855003480 hypothetical protein; Provisional; Region: PRK09866 439855003481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 439855003482 G1 box; other site 439855003483 GTP/Mg2+ binding site [chemical binding]; other site 439855003484 G2 box; other site 439855003485 Switch I region; other site 439855003486 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 439855003487 G3 box; other site 439855003488 Switch II region; other site 439855003489 GTP/Mg2+ binding site [chemical binding]; other site 439855003490 G4 box; other site 439855003491 G5 box; other site 439855003492 Predicted GTPase [General function prediction only]; Region: COG3596 439855003493 YfjP GTPase; Region: YfjP; cd11383 439855003494 G1 box; other site 439855003495 GTP/Mg2+ binding site [chemical binding]; other site 439855003496 Switch I region; other site 439855003497 G2 box; other site 439855003498 Switch II region; other site 439855003499 G3 box; other site 439855003500 G4 box; other site 439855003501 G5 box; other site 439855003502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855003503 Helix-turn-helix domain; Region: HTH_28; pfam13518 439855003504 Helix-turn-helix domain; Region: HTH_28; pfam13518 439855003505 putative transposase OrfB; Reviewed; Region: PHA02517 439855003506 HTH-like domain; Region: HTH_21; pfam13276 439855003507 Integrase core domain; Region: rve; pfam00665 439855003508 Integrase core domain; Region: rve_2; pfam13333 439855003509 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 439855003510 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 439855003511 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 439855003512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 439855003513 Transposase; Region: DDE_Tnp_ISL3; pfam01610 439855003514 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 439855003515 active site 439855003516 substrate binding pocket [chemical binding]; other site 439855003517 homodimer interaction site [polypeptide binding]; other site 439855003518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 439855003519 Protein of unknown function, DUF606; Region: DUF606; pfam04657 439855003520 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 439855003521 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 439855003522 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 439855003523 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855003524 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 439855003525 substrate binding site [chemical binding]; other site 439855003526 dimer interface [polypeptide binding]; other site 439855003527 ATP binding site [chemical binding]; other site 439855003528 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855003529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855003530 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855003531 HTH-like domain; Region: HTH_21; pfam13276 439855003532 Integrase core domain; Region: rve; pfam00665 439855003533 Integrase core domain; Region: rve_3; pfam13683 439855003534 Aspartase; Region: Aspartase; cd01357 439855003535 Lyase; Region: Lyase_1; pfam00206 439855003536 active sites [active] 439855003537 tetramer interface [polypeptide binding]; other site 439855003538 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 439855003539 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 439855003540 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 439855003541 aspartate racemase; Region: asp_race; TIGR00035 439855003542 cell density-dependent motility repressor; Provisional; Region: PRK10082 439855003543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855003544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 439855003545 dimerization interface [polypeptide binding]; other site 439855003546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855003547 D-galactonate transporter; Region: 2A0114; TIGR00893 439855003548 putative substrate translocation pore; other site 439855003549 galactonate dehydratase; Provisional; Region: PRK14017 439855003550 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 439855003551 putative active site pocket [active] 439855003552 putative metal binding site [ion binding]; other site 439855003553 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 439855003554 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 439855003555 active site 439855003556 intersubunit interface [polypeptide binding]; other site 439855003557 catalytic residue [active] 439855003558 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 439855003559 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 439855003560 Transcriptional regulators [Transcription]; Region: FadR; COG2186 439855003561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855003562 DNA-binding site [nucleotide binding]; DNA binding site 439855003563 FCD domain; Region: FCD; pfam07729 439855003564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855003565 Transposase; Region: HTH_Tnp_1; cl17663 439855003566 HTH-like domain; Region: HTH_21; pfam13276 439855003567 Integrase core domain; Region: rve; pfam00665 439855003568 DDE domain; Region: DDE_Tnp_IS240; pfam13610 439855003569 Integrase core domain; Region: rve_3; pfam13683 439855003570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 439855003571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855003572 metabolite-proton symporter; Region: 2A0106; TIGR00883 439855003573 putative substrate translocation pore; other site 439855003574 Transcriptional regulators [Transcription]; Region: PurR; COG1609 439855003575 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855003576 DNA binding site [nucleotide binding] 439855003577 domain linker motif; other site 439855003578 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 439855003579 dimerization interface [polypeptide binding]; other site 439855003580 ligand binding site [chemical binding]; other site 439855003581 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 439855003582 active site 439855003583 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 439855003584 MgtC family; Region: MgtC; pfam02308 439855003585 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 439855003586 catalytic nucleophile [active] 439855003587 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 439855003588 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 439855003589 peptidase T; Region: peptidase-T; TIGR01882 439855003590 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 439855003591 metal binding site [ion binding]; metal-binding site 439855003592 dimer interface [polypeptide binding]; other site 439855003593 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 439855003594 Aspartase; Region: Aspartase; cd01357 439855003595 active sites [active] 439855003596 tetramer interface [polypeptide binding]; other site 439855003597 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 439855003598 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 439855003599 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 439855003600 homodimer interface [polypeptide binding]; other site 439855003601 active site 439855003602 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 439855003603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855003604 active site 439855003605 phosphorylation site [posttranslational modification] 439855003606 intermolecular recognition site; other site 439855003607 dimerization interface [polypeptide binding]; other site 439855003608 Transcriptional regulators [Transcription]; Region: FadR; COG2186 439855003609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855003610 DNA-binding site [nucleotide binding]; DNA binding site 439855003611 FCD domain; Region: FCD; pfam07729 439855003612 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 439855003613 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 439855003614 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 439855003615 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 439855003616 argininosuccinate lyase; Provisional; Region: PRK00855 439855003617 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 439855003618 active sites [active] 439855003619 tetramer interface [polypeptide binding]; other site 439855003620 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 439855003621 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 439855003622 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 439855003623 Active Sites [active] 439855003624 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 439855003625 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 439855003626 homotrimer interface [polypeptide binding]; other site 439855003627 Walker A motif; other site 439855003628 GTP binding site [chemical binding]; other site 439855003629 Walker B motif; other site 439855003630 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 439855003631 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 439855003632 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 439855003633 putative dimer interface [polypeptide binding]; other site 439855003634 active site pocket [active] 439855003635 putative cataytic base [active] 439855003636 L,D-transpeptidase; Provisional; Region: PRK10190 439855003637 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855003638 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 439855003639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855003640 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 439855003641 putative dimerization interface [polypeptide binding]; other site 439855003642 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 439855003643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855003644 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 439855003645 putative substrate binding site [chemical binding]; other site 439855003646 dimerization interface [polypeptide binding]; other site 439855003647 MATE family multidrug exporter; Provisional; Region: PRK10189 439855003648 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 439855003649 hypothetical protein; Provisional; Region: PRK12378 439855003650 AMP nucleosidase; Provisional; Region: PRK08292 439855003651 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 439855003652 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 439855003653 shikimate transporter; Provisional; Region: PRK09952 439855003654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855003655 putative substrate translocation pore; other site 439855003656 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 439855003657 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 439855003658 putative invasin; Provisional; Region: PRK10177 439855003659 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 439855003660 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003661 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003662 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003663 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003664 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003665 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 439855003666 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 439855003667 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 439855003668 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003669 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 439855003670 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003671 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 439855003672 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855003673 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 439855003674 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 439855003675 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 439855003676 active site 439855003677 DNA binding site [nucleotide binding] 439855003678 Int/Topo IB signature motif; other site 439855003679 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 439855003680 exonuclease VIII; Reviewed; Region: PRK09709 439855003681 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 439855003682 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 439855003683 active site 439855003684 catalytic site [active] 439855003685 substrate binding site [chemical binding]; other site 439855003686 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 439855003687 DicB protein; Region: DicB; pfam05358 439855003688 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 439855003689 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 439855003690 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 439855003691 Pyocin large subunit [General function prediction only]; Region: COG5529 439855003692 Helix-turn-helix domain; Region: HTH_36; pfam13730 439855003693 primosomal protein DnaI; Provisional; Region: PRK02854 439855003694 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 439855003695 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 439855003696 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 439855003697 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 439855003698 adenylosuccinate lyase; Provisional; Region: PRK09285 439855003699 Protein of unknown function (DUF968); Region: DUF968; pfam06147 439855003700 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 439855003701 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 439855003702 Lysis protein S; Region: Lysis_S; pfam04971 439855003703 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 439855003704 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 439855003705 catalytic residues [active] 439855003706 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 439855003707 Phage terminase, small subunit; Region: Terminase_4; cl01525 439855003708 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 439855003709 Phage-related protein [Function unknown]; Region: COG4695 439855003710 Phage portal protein; Region: Phage_portal; pfam04860 439855003711 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 439855003712 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 439855003713 Phage capsid family; Region: Phage_capsid; pfam05065 439855003714 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 439855003715 oligomerization interface [polypeptide binding]; other site 439855003716 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 439855003717 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 439855003718 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 439855003719 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 439855003720 Phage-related minor tail protein [Function unknown]; Region: COG5281 439855003721 tape measure domain; Region: tape_meas_nterm; TIGR02675 439855003722 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 439855003723 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 439855003724 Phage minor tail protein; Region: Phage_min_tail; pfam05939 439855003725 Phage-related protein [Function unknown]; Region: gp18; COG4672 439855003726 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 439855003727 MPN+ (JAMM) motif; other site 439855003728 Zinc-binding site [ion binding]; other site 439855003729 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 439855003730 NlpC/P60 family; Region: NLPC_P60; cl17555 439855003731 Phage-related protein, tail component [Function unknown]; Region: COG4723 439855003732 Phage-related protein, tail component [Function unknown]; Region: COG4733 439855003733 Putative phage tail protein; Region: Phage-tail_3; pfam13550 439855003734 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 439855003735 Interdomain contacts; other site 439855003736 Cytokine receptor motif; other site 439855003737 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 439855003738 Fibronectin type III protein; Region: DUF3672; pfam12421 439855003739 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 439855003740 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 439855003741 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855003742 HTH-like domain; Region: HTH_21; pfam13276 439855003743 Integrase core domain; Region: rve; pfam00665 439855003744 Integrase core domain; Region: rve_3; pfam13683 439855003745 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855003746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855003747 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 439855003748 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 439855003749 zinc/cadmium-binding protein; Provisional; Region: PRK10306 439855003750 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 439855003751 TMAO/DMSO reductase; Reviewed; Region: PRK05363 439855003752 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 439855003753 Moco binding site; other site 439855003754 metal coordination site [ion binding]; other site 439855003755 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 439855003756 active site 439855003757 homotetramer interface [polypeptide binding]; other site 439855003758 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 439855003759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855003760 active site 439855003761 phosphorylation site [posttranslational modification] 439855003762 intermolecular recognition site; other site 439855003763 dimerization interface [polypeptide binding]; other site 439855003764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855003765 DNA binding site [nucleotide binding] 439855003766 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 439855003767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855003768 dimer interface [polypeptide binding]; other site 439855003769 phosphorylation site [posttranslational modification] 439855003770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855003771 ATP binding site [chemical binding]; other site 439855003772 Mg2+ binding site [ion binding]; other site 439855003773 G-X-G motif; other site 439855003774 chaperone protein HchA; Provisional; Region: PRK04155 439855003775 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 439855003776 dimer interface [polypeptide binding]; other site 439855003777 metal binding site [ion binding]; metal-binding site 439855003778 potential oxyanion hole; other site 439855003779 potential catalytic triad [active] 439855003780 conserved cys residue [active] 439855003781 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 439855003782 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 439855003783 trimer interface [polypeptide binding]; other site 439855003784 eyelet of channel; other site 439855003785 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 439855003786 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 439855003787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855003788 Zn2+ binding site [ion binding]; other site 439855003789 Mg2+ binding site [ion binding]; other site 439855003790 DNA cytosine methylase; Provisional; Region: PRK10458 439855003791 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 439855003792 cofactor binding site; other site 439855003793 DNA binding site [nucleotide binding] 439855003794 substrate interaction site [chemical binding]; other site 439855003795 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 439855003796 additional DNA contacts [nucleotide binding]; other site 439855003797 mismatch recognition site; other site 439855003798 active site 439855003799 zinc binding site [ion binding]; other site 439855003800 DNA intercalation site [nucleotide binding]; other site 439855003801 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 439855003802 EamA-like transporter family; Region: EamA; pfam00892 439855003803 hypothetical protein; Provisional; Region: PRK10062 439855003804 Uncharacterized small protein [Function unknown]; Region: COG5475 439855003805 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 439855003806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855003807 metal binding site [ion binding]; metal-binding site 439855003808 active site 439855003809 I-site; other site 439855003810 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 439855003811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855003812 active site 439855003813 motif I; other site 439855003814 motif II; other site 439855003815 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 439855003816 hypothetical protein; Provisional; Region: PRK10708 439855003817 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 439855003818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855003819 DNA binding residues [nucleotide binding] 439855003820 dimerization interface [polypeptide binding]; other site 439855003821 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 439855003822 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 439855003823 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 439855003824 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 439855003825 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 439855003826 flagellar motor switch protein; Validated; Region: fliN; PRK05698 439855003827 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 439855003828 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 439855003829 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 439855003830 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 439855003831 flagellar hook-length control protein; Provisional; Region: PRK10118 439855003832 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 439855003833 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 439855003834 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 439855003835 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 439855003836 Walker A motif/ATP binding site; other site 439855003837 Walker B motif; other site 439855003838 flagellar assembly protein H; Validated; Region: fliH; PRK05687 439855003839 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 439855003840 Flagellar assembly protein FliH; Region: FliH; pfam02108 439855003841 flagellar motor switch protein FliG; Region: fliG; TIGR00207 439855003842 FliG C-terminal domain; Region: FliG_C; pfam01706 439855003843 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 439855003844 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 439855003845 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 439855003846 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 439855003847 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 439855003848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 439855003849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855003850 Coenzyme A binding pocket [chemical binding]; other site 439855003851 hypothetical protein; Provisional; Region: PRK09951 439855003852 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 439855003853 CPxP motif; other site 439855003854 putative inner membrane protein; Provisional; Region: PRK11099 439855003855 lipoprotein; Provisional; Region: PRK10397 439855003856 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 439855003857 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 439855003858 active site 439855003859 Na/Ca binding site [ion binding]; other site 439855003860 catalytic site [active] 439855003861 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 439855003862 Flagellar protein FliS; Region: FliS; cl00654 439855003863 flagellar capping protein; Reviewed; Region: fliD; PRK08032 439855003864 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 439855003865 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 439855003866 flagellin; Validated; Region: PRK08026 439855003867 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 439855003868 Flagellin protein; Region: FliC; pfam12445 439855003869 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 439855003870 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 439855003871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 439855003872 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 439855003873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855003874 DNA binding residues [nucleotide binding] 439855003875 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 439855003876 cystine transporter subunit; Provisional; Region: PRK11260 439855003877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855003878 substrate binding pocket [chemical binding]; other site 439855003879 membrane-bound complex binding site; other site 439855003880 hinge residues; other site 439855003881 D-cysteine desulfhydrase; Validated; Region: PRK03910 439855003882 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 439855003883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855003884 catalytic residue [active] 439855003885 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855003886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855003887 dimer interface [polypeptide binding]; other site 439855003888 conserved gate region; other site 439855003889 putative PBP binding loops; other site 439855003890 ABC-ATPase subunit interface; other site 439855003891 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 439855003892 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 439855003893 Walker A/P-loop; other site 439855003894 ATP binding site [chemical binding]; other site 439855003895 Q-loop/lid; other site 439855003896 ABC transporter signature motif; other site 439855003897 Walker B; other site 439855003898 D-loop; other site 439855003899 H-loop/switch region; other site 439855003900 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 439855003901 Autoinducer binding domain; Region: Autoind_bind; pfam03472 439855003902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855003903 DNA binding residues [nucleotide binding] 439855003904 dimerization interface [polypeptide binding]; other site 439855003905 hypothetical protein; Provisional; Region: PRK10613 439855003906 response regulator; Provisional; Region: PRK09483 439855003907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855003908 active site 439855003909 phosphorylation site [posttranslational modification] 439855003910 intermolecular recognition site; other site 439855003911 dimerization interface [polypeptide binding]; other site 439855003912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855003913 DNA binding residues [nucleotide binding] 439855003914 dimerization interface [polypeptide binding]; other site 439855003915 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 439855003916 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 439855003917 GIY-YIG motif/motif A; other site 439855003918 active site 439855003919 catalytic site [active] 439855003920 putative DNA binding site [nucleotide binding]; other site 439855003921 metal binding site [ion binding]; metal-binding site 439855003922 UvrB/uvrC motif; Region: UVR; pfam02151 439855003923 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 439855003924 Helix-hairpin-helix motif; Region: HHH; pfam00633 439855003925 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 439855003926 hypothetical protein; Provisional; Region: PRK10396 439855003927 yecA family protein; Region: ygfB_yecA; TIGR02292 439855003928 SEC-C motif; Region: SEC-C; pfam02810 439855003929 tyrosine transporter TyrP; Provisional; Region: PRK15132 439855003930 aromatic amino acid transport protein; Region: araaP; TIGR00837 439855003931 probable metal-binding protein; Region: matur_matur; TIGR03853 439855003932 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 439855003933 Ferritin-like domain; Region: Ferritin; pfam00210 439855003934 ferroxidase diiron center [ion binding]; other site 439855003935 YecR-like lipoprotein; Region: YecR; pfam13992 439855003936 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 439855003937 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 439855003938 Ferritin-like domain; Region: Ferritin; pfam00210 439855003939 ferroxidase diiron center [ion binding]; other site 439855003940 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 439855003941 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 439855003942 ligand binding site [chemical binding]; other site 439855003943 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 439855003944 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855003945 Walker A/P-loop; other site 439855003946 ATP binding site [chemical binding]; other site 439855003947 Q-loop/lid; other site 439855003948 ABC transporter signature motif; other site 439855003949 Walker B; other site 439855003950 D-loop; other site 439855003951 H-loop/switch region; other site 439855003952 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855003953 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855003954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855003955 TM-ABC transporter signature motif; other site 439855003956 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 439855003957 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 439855003958 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 439855003959 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 439855003960 active site 439855003961 homotetramer interface [polypeptide binding]; other site 439855003962 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855003963 Ligand Binding Site [chemical binding]; other site 439855003964 transcriptional activator FlhD; Provisional; Region: PRK02909 439855003965 transcriptional activator FlhC; Provisional; Region: PRK12722 439855003966 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 439855003967 flagellar motor protein MotA; Validated; Region: PRK09110 439855003968 flagellar motor protein MotB; Validated; Region: motB; PRK09041 439855003969 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 439855003970 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855003971 ligand binding site [chemical binding]; other site 439855003972 chemotaxis protein CheA; Provisional; Region: PRK10547 439855003973 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 439855003974 putative binding surface; other site 439855003975 active site 439855003976 CheY binding; Region: CheY-binding; pfam09078 439855003977 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 439855003978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855003979 ATP binding site [chemical binding]; other site 439855003980 Mg2+ binding site [ion binding]; other site 439855003981 G-X-G motif; other site 439855003982 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 439855003983 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 439855003984 putative CheA interaction surface; other site 439855003985 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 439855003986 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 439855003987 dimer interface [polypeptide binding]; other site 439855003988 ligand binding site [chemical binding]; other site 439855003989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855003990 dimerization interface [polypeptide binding]; other site 439855003991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 439855003992 dimer interface [polypeptide binding]; other site 439855003993 putative CheW interface [polypeptide binding]; other site 439855003994 methyl-accepting protein IV; Provisional; Region: PRK09793 439855003995 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 439855003996 dimer interface [polypeptide binding]; other site 439855003997 ligand binding site [chemical binding]; other site 439855003998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855003999 dimerization interface [polypeptide binding]; other site 439855004000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 439855004001 dimer interface [polypeptide binding]; other site 439855004002 putative CheW interface [polypeptide binding]; other site 439855004003 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 439855004004 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 439855004005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855004006 S-adenosylmethionine binding site [chemical binding]; other site 439855004007 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 439855004008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855004009 active site 439855004010 phosphorylation site [posttranslational modification] 439855004011 intermolecular recognition site; other site 439855004012 dimerization interface [polypeptide binding]; other site 439855004013 CheB methylesterase; Region: CheB_methylest; pfam01339 439855004014 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 439855004015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855004016 active site 439855004017 phosphorylation site [posttranslational modification] 439855004018 intermolecular recognition site; other site 439855004019 dimerization interface [polypeptide binding]; other site 439855004020 chemotaxis regulator CheZ; Provisional; Region: PRK11166 439855004021 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 439855004022 metal binding triad [ion binding]; metal-binding site 439855004023 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 439855004024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855004025 Zn2+ binding site [ion binding]; other site 439855004026 Mg2+ binding site [ion binding]; other site 439855004027 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 439855004028 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 439855004029 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 439855004030 FHIPEP family; Region: FHIPEP; pfam00771 439855004031 Flagellar protein FlhE; Region: FlhE; pfam06366 439855004032 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 439855004033 arginyl-tRNA synthetase; Region: argS; TIGR00456 439855004034 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 439855004035 active site 439855004036 HIGH motif; other site 439855004037 KMSK motif region; other site 439855004038 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 439855004039 tRNA binding surface [nucleotide binding]; other site 439855004040 anticodon binding site; other site 439855004041 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 439855004042 putative metal binding site [ion binding]; other site 439855004043 copper homeostasis protein CutC; Provisional; Region: PRK11572 439855004044 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 439855004045 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 439855004046 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 439855004047 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 439855004048 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 439855004049 molybdopterin cofactor binding site [chemical binding]; other site 439855004050 substrate binding site [chemical binding]; other site 439855004051 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 439855004052 molybdopterin cofactor binding site; other site 439855004053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855004054 S-adenosylmethionine binding site [chemical binding]; other site 439855004055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855004056 S-adenosylmethionine binding site [chemical binding]; other site 439855004057 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 439855004058 hypothetical protein; Provisional; Region: PRK10302 439855004059 Isochorismatase family; Region: Isochorismatase; pfam00857 439855004060 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 439855004061 catalytic triad [active] 439855004062 conserved cis-peptide bond; other site 439855004063 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 439855004064 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 439855004065 dimer interface [polypeptide binding]; other site 439855004066 anticodon binding site; other site 439855004067 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 439855004068 homodimer interface [polypeptide binding]; other site 439855004069 motif 1; other site 439855004070 active site 439855004071 motif 2; other site 439855004072 GAD domain; Region: GAD; pfam02938 439855004073 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 439855004074 motif 3; other site 439855004075 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 439855004076 nudix motif; other site 439855004077 hypothetical protein; Validated; Region: PRK00110 439855004078 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 439855004079 active site 439855004080 putative DNA-binding cleft [nucleotide binding]; other site 439855004081 dimer interface [polypeptide binding]; other site 439855004082 hypothetical protein; Provisional; Region: PRK11470 439855004083 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 439855004084 RuvA N terminal domain; Region: RuvA_N; pfam01330 439855004085 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 439855004086 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 439855004087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855004088 Walker A motif; other site 439855004089 ATP binding site [chemical binding]; other site 439855004090 Walker B motif; other site 439855004091 arginine finger; other site 439855004092 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 439855004093 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 439855004094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855004095 ABC-ATPase subunit interface; other site 439855004096 dimer interface [polypeptide binding]; other site 439855004097 putative PBP binding regions; other site 439855004098 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 439855004099 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 439855004100 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 439855004101 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 439855004102 metal binding site [ion binding]; metal-binding site 439855004103 putative peptidase; Provisional; Region: PRK11649 439855004104 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 439855004105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855004106 Peptidase family M23; Region: Peptidase_M23; pfam01551 439855004107 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 439855004108 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 439855004109 putative acyl-acceptor binding pocket; other site 439855004110 pyruvate kinase; Provisional; Region: PRK05826 439855004111 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 439855004112 domain interfaces; other site 439855004113 active site 439855004114 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 439855004115 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 439855004116 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 439855004117 putative active site [active] 439855004118 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 439855004119 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 439855004120 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 439855004121 phosphogluconate dehydratase; Validated; Region: PRK09054 439855004122 6-phosphogluconate dehydratase; Region: edd; TIGR01196 439855004123 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 439855004124 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 439855004125 active site 439855004126 intersubunit interface [polypeptide binding]; other site 439855004127 catalytic residue [active] 439855004128 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 439855004129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 439855004130 ATP-grasp domain; Region: ATP-grasp; pfam02222 439855004131 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 439855004132 hypothetical protein; Provisional; Region: PRK13680 439855004133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 439855004134 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 439855004135 putative metal binding site [ion binding]; other site 439855004136 protease 2; Provisional; Region: PRK10115 439855004137 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 439855004138 exodeoxyribonuclease X; Provisional; Region: PRK07983 439855004139 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 439855004140 active site 439855004141 catalytic site [active] 439855004142 substrate binding site [chemical binding]; other site 439855004143 Predicted amidohydrolase [General function prediction only]; Region: COG0388 439855004144 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 439855004145 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 439855004146 hypothetical protein; Provisional; Region: PRK10301 439855004147 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 439855004148 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 439855004149 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 439855004150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 439855004151 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 439855004152 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 439855004153 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 439855004154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855004155 S-adenosylmethionine binding site [chemical binding]; other site 439855004156 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 439855004157 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 439855004158 mce related protein; Region: MCE; pfam02470 439855004159 mce related protein; Region: MCE; pfam02470 439855004160 mce related protein; Region: MCE; pfam02470 439855004161 mce related protein; Region: MCE; pfam02470 439855004162 mce related protein; Region: MCE; pfam02470 439855004163 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 439855004164 Paraquat-inducible protein A; Region: PqiA; pfam04403 439855004165 Paraquat-inducible protein A; Region: PqiA; pfam04403 439855004166 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 439855004167 GAF domain; Region: GAF_2; pfam13185 439855004168 ProP expression regulator; Provisional; Region: PRK04950 439855004169 ProQ/FINO family; Region: ProQ; pfam04352 439855004170 carboxy-terminal protease; Provisional; Region: PRK11186 439855004171 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 439855004172 protein binding site [polypeptide binding]; other site 439855004173 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 439855004174 Catalytic dyad [active] 439855004175 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 439855004176 heat shock protein HtpX; Provisional; Region: PRK05457 439855004177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855004179 putative substrate translocation pore; other site 439855004180 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 439855004181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855004182 dimerization interface [polypeptide binding]; other site 439855004183 putative Zn2+ binding site [ion binding]; other site 439855004184 putative DNA binding site [nucleotide binding]; other site 439855004185 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855004186 YobH-like protein; Region: YobH; pfam13996 439855004187 PhoPQ regulatory protein; Provisional; Region: PRK10299 439855004188 YebO-like protein; Region: YebO; pfam13974 439855004189 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 439855004190 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 439855004191 DNA-binding site [nucleotide binding]; DNA binding site 439855004192 RNA-binding motif; other site 439855004193 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 439855004194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855004195 S-adenosylmethionine binding site [chemical binding]; other site 439855004196 hypothetical protein; Provisional; Region: PRK11469 439855004197 Domain of unknown function DUF; Region: DUF204; pfam02659 439855004198 Domain of unknown function DUF; Region: DUF204; pfam02659 439855004199 Predicted membrane protein [Function unknown]; Region: COG4811 439855004200 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 439855004201 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 439855004202 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 439855004203 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 439855004204 active pocket/dimerization site; other site 439855004205 active site 439855004206 phosphorylation site [posttranslational modification] 439855004207 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 439855004208 active site 439855004209 phosphorylation site [posttranslational modification] 439855004210 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 439855004211 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 439855004212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 439855004213 Transporter associated domain; Region: CorC_HlyC; smart01091 439855004214 phage resistance protein; Provisional; Region: PRK10551 439855004215 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 439855004216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855004217 L-serine deaminase; Provisional; Region: PRK15023 439855004218 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 439855004219 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 439855004220 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 439855004221 putative active site [active] 439855004222 putative CoA binding site [chemical binding]; other site 439855004223 nudix motif; other site 439855004224 metal binding site [ion binding]; metal-binding site 439855004225 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 439855004226 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 439855004227 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 439855004228 hypothetical protein; Provisional; Region: PRK05114 439855004229 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 439855004230 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 439855004231 homotrimer interaction site [polypeptide binding]; other site 439855004232 putative active site [active] 439855004233 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 439855004234 DEAD/DEAH box helicase; Region: DEAD; pfam00270 439855004235 DEAD_2; Region: DEAD_2; pfam06733 439855004236 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 439855004237 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 439855004238 Glycoprotease family; Region: Peptidase_M22; pfam00814 439855004239 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 439855004240 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 439855004241 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 439855004242 acyl-activating enzyme (AAE) consensus motif; other site 439855004243 putative AMP binding site [chemical binding]; other site 439855004244 putative active site [active] 439855004245 putative CoA binding site [chemical binding]; other site 439855004246 ribonuclease D; Provisional; Region: PRK10829 439855004247 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 439855004248 catalytic site [active] 439855004249 putative active site [active] 439855004250 putative substrate binding site [chemical binding]; other site 439855004251 Helicase and RNase D C-terminal; Region: HRDC; smart00341 439855004252 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 439855004253 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 439855004254 FMN-binding pocket [chemical binding]; other site 439855004255 flavin binding motif; other site 439855004256 phosphate binding motif [ion binding]; other site 439855004257 beta-alpha-beta structure motif; other site 439855004258 NAD binding pocket [chemical binding]; other site 439855004259 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855004260 catalytic loop [active] 439855004261 iron binding site [ion binding]; other site 439855004262 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 439855004263 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 439855004264 [2Fe-2S] cluster binding site [ion binding]; other site 439855004265 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 439855004266 putative alpha subunit interface [polypeptide binding]; other site 439855004267 putative active site [active] 439855004268 putative substrate binding site [chemical binding]; other site 439855004269 Fe binding site [ion binding]; other site 439855004270 putative transporter; Provisional; Region: PRK09950 439855004271 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 439855004272 tartrate dehydrogenase; Region: TTC; TIGR02089 439855004273 transcriptional activator TtdR; Provisional; Region: PRK09801 439855004274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855004275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 439855004276 putative effector binding pocket; other site 439855004277 putative dimerization interface [polypeptide binding]; other site 439855004278 leucine export protein LeuE; Provisional; Region: PRK10958 439855004279 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 439855004280 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 439855004281 hypothetical protein; Provisional; Region: PRK10457 439855004282 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 439855004283 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 439855004284 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855004285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855004286 metal binding site [ion binding]; metal-binding site 439855004287 active site 439855004288 I-site; other site 439855004289 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 439855004290 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 439855004291 Domain of unknown function (DUF333); Region: DUF333; pfam03891 439855004292 Uncharacterized conserved protein [Function unknown]; Region: COG3189 439855004293 cyanate transporter; Region: CynX; TIGR00896 439855004294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004295 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855004296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855004297 Predicted membrane protein [Function unknown]; Region: COG2707 439855004298 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 439855004299 putative deacylase active site [active] 439855004300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855004301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855004302 metal binding site [ion binding]; metal-binding site 439855004303 active site 439855004304 I-site; other site 439855004305 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855004306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855004307 metal binding site [ion binding]; metal-binding site 439855004308 active site 439855004309 I-site; other site 439855004310 hypothetical protein; Provisional; Region: PRK05325 439855004311 PrkA family serine protein kinase; Provisional; Region: PRK15455 439855004312 AAA ATPase domain; Region: AAA_16; pfam13191 439855004313 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 439855004314 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 439855004315 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855004316 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855004317 active site 439855004318 catalytic tetrad [active] 439855004319 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 439855004320 active site 439855004321 phosphate binding residues; other site 439855004322 catalytic residues [active] 439855004323 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 439855004324 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 439855004325 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 439855004326 methionine sulfoxide reductase B; Provisional; Region: PRK00222 439855004327 SelR domain; Region: SelR; pfam01641 439855004328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 439855004329 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855004330 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 439855004331 putative NAD(P) binding site [chemical binding]; other site 439855004332 catalytic Zn binding site [ion binding]; other site 439855004333 structural Zn binding site [ion binding]; other site 439855004334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004336 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855004337 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 439855004338 inhibitor binding site; inhibition site 439855004339 catalytic Zn binding site [ion binding]; other site 439855004340 structural Zn binding site [ion binding]; other site 439855004341 NADP binding site [chemical binding]; other site 439855004342 tetramer interface [polypeptide binding]; other site 439855004343 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 439855004344 intersubunit interface [polypeptide binding]; other site 439855004345 active site 439855004346 zinc binding site [ion binding]; other site 439855004347 Na+ binding site [ion binding]; other site 439855004348 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855004349 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 439855004350 substrate binding site [chemical binding]; other site 439855004351 ATP binding site [chemical binding]; other site 439855004352 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855004353 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855004354 active site 439855004355 catalytic tetrad [active] 439855004356 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 439855004357 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 439855004358 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855004359 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 439855004360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004361 putative substrate translocation pore; other site 439855004362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004363 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 439855004364 Isochorismatase family; Region: Isochorismatase; pfam00857 439855004365 catalytic triad [active] 439855004366 metal binding site [ion binding]; metal-binding site 439855004367 conserved cis-peptide bond; other site 439855004368 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 439855004369 active site 439855004370 homodimer interface [polypeptide binding]; other site 439855004371 protease 4; Provisional; Region: PRK10949 439855004372 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 439855004373 tandem repeat interface [polypeptide binding]; other site 439855004374 oligomer interface [polypeptide binding]; other site 439855004375 active site residues [active] 439855004376 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 439855004377 tandem repeat interface [polypeptide binding]; other site 439855004378 oligomer interface [polypeptide binding]; other site 439855004379 active site residues [active] 439855004380 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 439855004381 putative FMN binding site [chemical binding]; other site 439855004382 selenophosphate synthetase; Provisional; Region: PRK00943 439855004383 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 439855004384 dimerization interface [polypeptide binding]; other site 439855004385 putative ATP binding site [chemical binding]; other site 439855004386 DNA topoisomerase III; Provisional; Region: PRK07726 439855004387 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 439855004388 active site 439855004389 putative interdomain interaction site [polypeptide binding]; other site 439855004390 putative metal-binding site [ion binding]; other site 439855004391 putative nucleotide binding site [chemical binding]; other site 439855004392 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 439855004393 domain I; other site 439855004394 DNA binding groove [nucleotide binding] 439855004395 phosphate binding site [ion binding]; other site 439855004396 domain II; other site 439855004397 domain III; other site 439855004398 nucleotide binding site [chemical binding]; other site 439855004399 catalytic site [active] 439855004400 domain IV; other site 439855004401 glutamate dehydrogenase; Provisional; Region: PRK09414 439855004402 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 439855004403 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 439855004404 NAD(P) binding site [chemical binding]; other site 439855004405 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 439855004406 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 439855004407 active site 439855004408 8-oxo-dGMP binding site [chemical binding]; other site 439855004409 nudix motif; other site 439855004410 metal binding site [ion binding]; metal-binding site 439855004411 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 439855004412 Rhodanese Homology Domain; Region: RHOD; smart00450 439855004413 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 439855004414 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 439855004415 active site residue [active] 439855004416 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 439855004417 active site residue [active] 439855004418 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 439855004419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855004420 Walker A/P-loop; other site 439855004421 ATP binding site [chemical binding]; other site 439855004422 Q-loop/lid; other site 439855004423 ABC transporter signature motif; other site 439855004424 Walker B; other site 439855004425 D-loop; other site 439855004426 H-loop/switch region; other site 439855004427 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 439855004428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855004429 putative PBP binding loops; other site 439855004430 ABC-ATPase subunit interface; other site 439855004431 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 439855004432 hypothetical protein; Provisional; Region: PRK11622 439855004433 Uncharacterized conserved protein [Function unknown]; Region: COG2128 439855004434 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 439855004435 Uncharacterized conserved protein [Function unknown]; Region: COG0398 439855004436 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 439855004437 Uncharacterized conserved protein [Function unknown]; Region: COG0398 439855004438 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 439855004439 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 439855004440 putative catalytic site [active] 439855004441 putative phosphate binding site [ion binding]; other site 439855004442 active site 439855004443 metal binding site A [ion binding]; metal-binding site 439855004444 DNA binding site [nucleotide binding] 439855004445 putative AP binding site [nucleotide binding]; other site 439855004446 putative metal binding site B [ion binding]; other site 439855004447 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 439855004448 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855004449 inhibitor-cofactor binding pocket; inhibition site 439855004450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855004451 catalytic residue [active] 439855004452 arginine succinyltransferase; Provisional; Region: PRK10456 439855004453 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 439855004454 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 439855004455 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 439855004456 NAD(P) binding site [chemical binding]; other site 439855004457 catalytic residues [active] 439855004458 succinylarginine dihydrolase; Provisional; Region: PRK13281 439855004459 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 439855004460 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 439855004461 putative active site [active] 439855004462 Zn binding site [ion binding]; other site 439855004463 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 439855004464 dimer interface [polypeptide binding]; other site 439855004465 hypothetical protein; Provisional; Region: PRK11396 439855004466 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 439855004467 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 439855004468 GIY-YIG motif/motif A; other site 439855004469 active site 439855004470 catalytic site [active] 439855004471 putative DNA binding site [nucleotide binding]; other site 439855004472 metal binding site [ion binding]; metal-binding site 439855004473 NAD+ synthetase; Region: nadE; TIGR00552 439855004474 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 439855004475 homodimer interface [polypeptide binding]; other site 439855004476 NAD binding pocket [chemical binding]; other site 439855004477 ATP binding pocket [chemical binding]; other site 439855004478 Mg binding site [ion binding]; other site 439855004479 active-site loop [active] 439855004480 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 439855004481 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 439855004482 active site 439855004483 P-loop; other site 439855004484 phosphorylation site [posttranslational modification] 439855004485 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 439855004486 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 439855004487 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 439855004488 methionine cluster; other site 439855004489 active site 439855004490 phosphorylation site [posttranslational modification] 439855004491 metal binding site [ion binding]; metal-binding site 439855004492 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 439855004493 Cupin domain; Region: Cupin_2; pfam07883 439855004494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855004495 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 439855004496 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 439855004497 NAD binding site [chemical binding]; other site 439855004498 sugar binding site [chemical binding]; other site 439855004499 divalent metal binding site [ion binding]; other site 439855004500 tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855004501 dimer interface [polypeptide binding]; other site 439855004502 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 439855004503 putative active site [active] 439855004504 YdjC motif; other site 439855004505 Mg binding site [ion binding]; other site 439855004506 putative homodimer interface [polypeptide binding]; other site 439855004507 hydroperoxidase II; Provisional; Region: katE; PRK11249 439855004508 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 439855004509 tetramer interface [polypeptide binding]; other site 439855004510 heme binding pocket [chemical binding]; other site 439855004511 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 439855004512 domain interactions; other site 439855004513 cell division modulator; Provisional; Region: PRK10113 439855004514 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 439855004515 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 439855004516 inner membrane protein; Provisional; Region: PRK11648 439855004517 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 439855004518 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 439855004519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855004520 motif II; other site 439855004521 YniB-like protein; Region: YniB; pfam14002 439855004522 Phosphotransferase enzyme family; Region: APH; pfam01636 439855004523 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 439855004524 active site 439855004525 ATP binding site [chemical binding]; other site 439855004526 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 439855004527 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 439855004528 6-phosphofructokinase 2; Provisional; Region: PRK10294 439855004529 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 439855004530 putative substrate binding site [chemical binding]; other site 439855004531 putative ATP binding site [chemical binding]; other site 439855004532 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 439855004533 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 439855004534 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 439855004535 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 439855004536 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 439855004537 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 439855004538 active site 439855004539 dimer interface [polypeptide binding]; other site 439855004540 motif 1; other site 439855004541 motif 2; other site 439855004542 motif 3; other site 439855004543 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 439855004544 anticodon binding site; other site 439855004545 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 439855004546 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 439855004547 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 439855004548 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 439855004549 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 439855004550 23S rRNA binding site [nucleotide binding]; other site 439855004551 L21 binding site [polypeptide binding]; other site 439855004552 L13 binding site [polypeptide binding]; other site 439855004553 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 439855004554 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 439855004555 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 439855004556 dimer interface [polypeptide binding]; other site 439855004557 motif 1; other site 439855004558 active site 439855004559 motif 2; other site 439855004560 motif 3; other site 439855004561 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 439855004562 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 439855004563 putative tRNA-binding site [nucleotide binding]; other site 439855004564 B3/4 domain; Region: B3_4; pfam03483 439855004565 tRNA synthetase B5 domain; Region: B5; smart00874 439855004566 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 439855004567 dimer interface [polypeptide binding]; other site 439855004568 motif 1; other site 439855004569 motif 3; other site 439855004570 motif 2; other site 439855004571 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 439855004572 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 439855004573 IHF dimer interface [polypeptide binding]; other site 439855004574 IHF - DNA interface [nucleotide binding]; other site 439855004575 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 439855004576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855004577 ABC-ATPase subunit interface; other site 439855004578 dimer interface [polypeptide binding]; other site 439855004579 putative PBP binding regions; other site 439855004580 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 439855004581 catalytic residues [active] 439855004582 dimer interface [polypeptide binding]; other site 439855004583 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 439855004584 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 439855004585 Walker A/P-loop; other site 439855004586 ATP binding site [chemical binding]; other site 439855004587 Q-loop/lid; other site 439855004588 ABC transporter signature motif; other site 439855004589 Walker B; other site 439855004590 D-loop; other site 439855004591 H-loop/switch region; other site 439855004592 NlpC/P60 family; Region: NLPC_P60; pfam00877 439855004593 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 439855004594 Uncharacterized conserved protein [Function unknown]; Region: COG0397 439855004595 hypothetical protein; Validated; Region: PRK00029 439855004596 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 439855004597 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 439855004598 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 439855004599 PEP synthetase regulatory protein; Provisional; Region: PRK05339 439855004600 phosphoenolpyruvate synthase; Validated; Region: PRK06464 439855004601 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 439855004602 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855004603 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 439855004604 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 439855004605 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 439855004606 transmembrane helices; other site 439855004607 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 439855004608 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 439855004609 putative ligand binding site [chemical binding]; other site 439855004610 NAD binding site [chemical binding]; other site 439855004611 catalytic site [active] 439855004612 Domain of unknown function (DUF386); Region: DUF386; cl01047 439855004613 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 439855004614 classical (c) SDRs; Region: SDR_c; cd05233 439855004615 NAD(P) binding site [chemical binding]; other site 439855004616 active site 439855004617 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 439855004618 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 439855004619 acyl-activating enzyme (AAE) consensus motif; other site 439855004620 putative AMP binding site [chemical binding]; other site 439855004621 putative active site [active] 439855004622 putative CoA binding site [chemical binding]; other site 439855004623 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 439855004624 oxidoreductase; Provisional; Region: PRK10015 439855004625 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 439855004626 Electron transfer flavoprotein domain; Region: ETF; smart00893 439855004627 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 439855004628 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 439855004629 Ligand binding site [chemical binding]; other site 439855004630 Electron transfer flavoprotein domain; Region: ETF; pfam01012 439855004631 Cupin domain; Region: Cupin_2; pfam07883 439855004632 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 439855004633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855004634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855004635 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 439855004636 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 439855004637 active site 439855004638 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 439855004639 Coenzyme A transferase; Region: CoA_trans; smart00882 439855004640 Coenzyme A transferase; Region: CoA_trans; cl17247 439855004641 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 439855004642 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 439855004643 active site 439855004644 catalytic residue [active] 439855004645 dimer interface [polypeptide binding]; other site 439855004646 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 439855004647 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 439855004648 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 439855004649 shikimate binding site; other site 439855004650 NAD(P) binding site [chemical binding]; other site 439855004651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004652 putative substrate translocation pore; other site 439855004653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855004655 putative substrate translocation pore; other site 439855004656 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 439855004657 putative inner membrane protein; Provisional; Region: PRK10983 439855004658 Domain of unknown function DUF20; Region: UPF0118; pfam01594 439855004659 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 439855004660 FAD binding domain; Region: FAD_binding_4; pfam01565 439855004661 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 439855004662 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 439855004663 CoenzymeA binding site [chemical binding]; other site 439855004664 subunit interaction site [polypeptide binding]; other site 439855004665 PHB binding site; other site 439855004666 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 439855004667 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 439855004668 putative ABC transporter; Region: ycf24; CHL00085 439855004669 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 439855004670 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 439855004671 Walker A/P-loop; other site 439855004672 ATP binding site [chemical binding]; other site 439855004673 Q-loop/lid; other site 439855004674 ABC transporter signature motif; other site 439855004675 Walker B; other site 439855004676 D-loop; other site 439855004677 H-loop/switch region; other site 439855004678 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 439855004679 FeS assembly protein SufD; Region: sufD; TIGR01981 439855004680 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 439855004681 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 439855004682 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855004683 catalytic residue [active] 439855004684 cysteine desufuration protein SufE; Provisional; Region: PRK09296 439855004685 L,D-transpeptidase; Provisional; Region: PRK10190 439855004686 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855004687 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855004688 murein lipoprotein; Provisional; Region: PRK15396 439855004689 pyruvate kinase; Provisional; Region: PRK09206 439855004690 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 439855004691 domain interfaces; other site 439855004692 active site 439855004693 hypothetical protein; Provisional; Region: PRK10292 439855004694 hypothetical protein; Provisional; Region: PRK09898 439855004695 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855004696 putative oxidoreductase; Provisional; Region: PRK09849 439855004697 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 439855004698 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 439855004699 hypothetical protein; Provisional; Region: PRK09947 439855004700 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 439855004701 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 439855004702 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 439855004703 hypothetical protein; Provisional; Region: PRK09946 439855004704 putative monooxygenase; Provisional; Region: PRK11118 439855004705 hypothetical protein; Provisional; Region: PRK09945 439855004706 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 439855004707 multidrug efflux protein; Reviewed; Region: PRK01766 439855004708 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 439855004709 cation binding site [ion binding]; other site 439855004710 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 439855004711 Lumazine binding domain; Region: Lum_binding; pfam00677 439855004712 Lumazine binding domain; Region: Lum_binding; pfam00677 439855004713 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 439855004714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 439855004715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855004716 S-adenosylmethionine binding site [chemical binding]; other site 439855004717 putative transporter; Provisional; Region: PRK11043 439855004718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004719 putative substrate translocation pore; other site 439855004720 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 439855004721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855004722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855004723 dimerization interface [polypeptide binding]; other site 439855004724 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 439855004725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855004726 DNA binding site [nucleotide binding] 439855004727 domain linker motif; other site 439855004728 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 439855004729 dimerization interface [polypeptide binding]; other site 439855004730 ligand binding site [chemical binding]; other site 439855004731 hypothetical protein; Provisional; Region: PRK14756 439855004732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855004734 putative substrate translocation pore; other site 439855004735 superoxide dismutase; Provisional; Region: PRK10543 439855004736 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 439855004737 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 439855004738 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 439855004739 NlpC/P60 family; Region: NLPC_P60; pfam00877 439855004740 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 439855004741 putative GSH binding site [chemical binding]; other site 439855004742 catalytic residues [active] 439855004743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855004744 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 439855004745 ATP binding site [chemical binding]; other site 439855004746 putative Mg++ binding site [ion binding]; other site 439855004747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855004748 nucleotide binding region [chemical binding]; other site 439855004749 ATP-binding site [chemical binding]; other site 439855004750 DEAD/H associated; Region: DEAD_assoc; pfam08494 439855004751 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 439855004752 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 439855004753 dimer interface [polypeptide binding]; other site 439855004754 catalytic site [active] 439855004755 putative active site [active] 439855004756 putative substrate binding site [chemical binding]; other site 439855004757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 439855004758 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 439855004759 dimer interface [polypeptide binding]; other site 439855004760 active site 439855004761 metal binding site [ion binding]; metal-binding site 439855004762 glutathione binding site [chemical binding]; other site 439855004763 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 439855004764 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 439855004765 FMN binding site [chemical binding]; other site 439855004766 active site 439855004767 substrate binding site [chemical binding]; other site 439855004768 catalytic residue [active] 439855004769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 439855004770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855004771 Predicted Fe-S protein [General function prediction only]; Region: COG3313 439855004772 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855004773 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855004774 active site 439855004775 catalytic tetrad [active] 439855004776 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 439855004777 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 439855004778 E-class dimer interface [polypeptide binding]; other site 439855004779 P-class dimer interface [polypeptide binding]; other site 439855004780 active site 439855004781 Cu2+ binding site [ion binding]; other site 439855004782 Zn2+ binding site [ion binding]; other site 439855004783 Fusaric acid resistance protein family; Region: FUSC; pfam04632 439855004784 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 439855004785 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 439855004786 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855004787 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855004788 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 439855004789 transcriptional regulator SlyA; Provisional; Region: PRK03573 439855004790 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 439855004791 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 439855004792 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 439855004793 lysozyme inhibitor; Provisional; Region: PRK11372 439855004794 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 439855004795 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 439855004796 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 439855004797 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 439855004798 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 439855004799 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 439855004800 active site 439855004801 HIGH motif; other site 439855004802 dimer interface [polypeptide binding]; other site 439855004803 KMSKS motif; other site 439855004804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855004805 RNA binding surface [nucleotide binding]; other site 439855004806 pyridoxamine kinase; Validated; Region: PRK05756 439855004807 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 439855004808 dimer interface [polypeptide binding]; other site 439855004809 pyridoxal binding site [chemical binding]; other site 439855004810 ATP binding site [chemical binding]; other site 439855004811 glutathionine S-transferase; Provisional; Region: PRK10542 439855004812 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 439855004813 C-terminal domain interface [polypeptide binding]; other site 439855004814 GSH binding site (G-site) [chemical binding]; other site 439855004815 dimer interface [polypeptide binding]; other site 439855004816 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 439855004817 N-terminal domain interface [polypeptide binding]; other site 439855004818 dimer interface [polypeptide binding]; other site 439855004819 substrate binding pocket (H-site) [chemical binding]; other site 439855004820 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 439855004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004822 putative substrate translocation pore; other site 439855004823 POT family; Region: PTR2; pfam00854 439855004824 endonuclease III; Provisional; Region: PRK10702 439855004825 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 439855004826 minor groove reading motif; other site 439855004827 helix-hairpin-helix signature motif; other site 439855004828 substrate binding pocket [chemical binding]; other site 439855004829 active site 439855004830 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 439855004831 electron transport complex RsxE subunit; Provisional; Region: PRK12405 439855004832 electron transport complex protein RnfG; Validated; Region: PRK01908 439855004833 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 439855004834 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 439855004835 SLBB domain; Region: SLBB; pfam10531 439855004836 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855004837 electron transport complex protein RnfB; Provisional; Region: PRK05113 439855004838 Putative Fe-S cluster; Region: FeS; pfam04060 439855004839 4Fe-4S binding domain; Region: Fer4; pfam00037 439855004840 electron transport complex protein RsxA; Provisional; Region: PRK05151 439855004841 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 439855004842 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 439855004843 putative oxidoreductase; Provisional; Region: PRK11579 439855004844 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 439855004845 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 439855004846 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 439855004847 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 439855004848 active site 439855004849 purine riboside binding site [chemical binding]; other site 439855004850 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 439855004851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855004852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855004853 homodimer interface [polypeptide binding]; other site 439855004854 catalytic residue [active] 439855004855 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 439855004856 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 439855004857 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855004858 active site turn [active] 439855004859 phosphorylation site [posttranslational modification] 439855004860 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 439855004861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855004862 DNA binding site [nucleotide binding] 439855004863 domain linker motif; other site 439855004864 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 439855004865 putative dimerization interface [polypeptide binding]; other site 439855004866 putative ligand binding site [chemical binding]; other site 439855004867 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 439855004868 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 439855004869 NAD binding site [chemical binding]; other site 439855004870 substrate binding site [chemical binding]; other site 439855004871 homotetramer interface [polypeptide binding]; other site 439855004872 homodimer interface [polypeptide binding]; other site 439855004873 active site 439855004874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 439855004875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855004876 beta-D-glucuronidase; Provisional; Region: PRK10150 439855004877 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 439855004878 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 439855004879 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 439855004880 glucuronide transporter; Provisional; Region: PRK09848 439855004881 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 439855004882 putative outer membrane porin protein; Provisional; Region: PRK11379 439855004883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 439855004884 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 439855004885 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 439855004886 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 439855004887 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 439855004888 fumarate hydratase; Provisional; Region: PRK15389 439855004889 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 439855004890 Fumarase C-terminus; Region: Fumerase_C; pfam05683 439855004891 fumarate hydratase; Reviewed; Region: fumC; PRK00485 439855004892 Class II fumarases; Region: Fumarase_classII; cd01362 439855004893 active site 439855004894 tetramer interface [polypeptide binding]; other site 439855004895 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 439855004896 sensor protein RstB; Provisional; Region: PRK10604 439855004897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855004898 dimerization interface [polypeptide binding]; other site 439855004899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855004900 dimer interface [polypeptide binding]; other site 439855004901 phosphorylation site [posttranslational modification] 439855004902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855004903 ATP binding site [chemical binding]; other site 439855004904 Mg2+ binding site [ion binding]; other site 439855004905 G-X-G motif; other site 439855004906 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 439855004907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855004908 active site 439855004909 phosphorylation site [posttranslational modification] 439855004910 intermolecular recognition site; other site 439855004911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855004912 DNA binding site [nucleotide binding] 439855004913 GlpM protein; Region: GlpM; pfam06942 439855004914 dihydromonapterin reductase; Provisional; Region: PRK06483 439855004915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 439855004916 NAD(P) binding site [chemical binding]; other site 439855004917 active site 439855004918 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 439855004919 Spore germination protein; Region: Spore_permease; cl17796 439855004920 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855004921 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855004922 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855004923 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 439855004924 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 439855004925 ligand binding site [chemical binding]; other site 439855004926 homodimer interface [polypeptide binding]; other site 439855004927 NAD(P) binding site [chemical binding]; other site 439855004928 trimer interface B [polypeptide binding]; other site 439855004929 trimer interface A [polypeptide binding]; other site 439855004930 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 439855004931 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 439855004932 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 439855004933 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 439855004934 Domain of unknown function DUF20; Region: UPF0118; pfam01594 439855004935 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 439855004936 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 439855004937 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 439855004938 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855004939 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 439855004940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004941 putative substrate translocation pore; other site 439855004942 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 439855004943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855004944 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 439855004945 dimerization interface [polypeptide binding]; other site 439855004946 substrate binding pocket [chemical binding]; other site 439855004947 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 439855004948 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 439855004949 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855004950 nucleotide binding site [chemical binding]; other site 439855004951 putative dithiobiotin synthetase; Provisional; Region: PRK12374 439855004952 AAA domain; Region: AAA_26; pfam13500 439855004953 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 439855004954 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 439855004955 Cl- selectivity filter; other site 439855004956 Cl- binding residues [ion binding]; other site 439855004957 pore gating glutamate residue; other site 439855004958 dimer interface [polypeptide binding]; other site 439855004959 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 439855004960 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 439855004961 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 439855004962 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 439855004963 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 439855004964 putative [Fe4-S4] binding site [ion binding]; other site 439855004965 putative molybdopterin cofactor binding site [chemical binding]; other site 439855004966 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 439855004967 putative molybdopterin cofactor binding site; other site 439855004968 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 439855004969 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 439855004970 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 439855004971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855004972 Coenzyme A binding pocket [chemical binding]; other site 439855004973 hypothetical protein; Provisional; Region: PRK13659 439855004974 hypothetical protein; Provisional; Region: PRK02237 439855004975 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 439855004976 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 439855004977 putative active site pocket [active] 439855004978 putative metal binding site [ion binding]; other site 439855004979 putative oxidoreductase; Provisional; Region: PRK10083 439855004980 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 439855004981 putative NAD(P) binding site [chemical binding]; other site 439855004982 catalytic Zn binding site [ion binding]; other site 439855004983 structural Zn binding site [ion binding]; other site 439855004984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855004985 metabolite-proton symporter; Region: 2A0106; TIGR00883 439855004986 putative substrate translocation pore; other site 439855004987 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 439855004988 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 439855004989 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 439855004990 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 439855004991 Transcriptional regulators [Transcription]; Region: GntR; COG1802 439855004992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855004993 DNA-binding site [nucleotide binding]; DNA binding site 439855004994 FCD domain; Region: FCD; pfam07729 439855004995 malonic semialdehyde reductase; Provisional; Region: PRK10538 439855004996 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 439855004997 putative NAD(P) binding site [chemical binding]; other site 439855004998 homodimer interface [polypeptide binding]; other site 439855004999 homotetramer interface [polypeptide binding]; other site 439855005000 active site 439855005001 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 439855005002 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 439855005003 active site 439855005004 Zn binding site [ion binding]; other site 439855005005 hypothetical protein; Provisional; Region: PRK10053 439855005006 diguanylate cyclase; Provisional; Region: PRK09894 439855005007 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 439855005008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005009 metal binding site [ion binding]; metal-binding site 439855005010 active site 439855005011 I-site; other site 439855005012 putative transporter; Provisional; Region: PRK10054 439855005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855005014 putative substrate translocation pore; other site 439855005015 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 439855005016 EamA-like transporter family; Region: EamA; pfam00892 439855005017 EamA-like transporter family; Region: EamA; pfam00892 439855005018 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 439855005019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855005020 DNA-binding site [nucleotide binding]; DNA binding site 439855005021 UTRA domain; Region: UTRA; pfam07702 439855005022 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 439855005023 active site 439855005024 P-loop; other site 439855005025 phosphorylation site [posttranslational modification] 439855005026 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 439855005027 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 439855005028 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 439855005029 active site 439855005030 methionine cluster; other site 439855005031 phosphorylation site [posttranslational modification] 439855005032 metal binding site [ion binding]; metal-binding site 439855005033 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 439855005034 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 439855005035 trimer interface; other site 439855005036 sugar binding site [chemical binding]; other site 439855005037 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 439855005038 beta-galactosidase; Region: BGL; TIGR03356 439855005039 hypothetical protein; Provisional; Region: PRK10106 439855005040 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 439855005041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855005042 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 439855005043 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 439855005044 inner membrane protein; Provisional; Region: PRK10995 439855005045 putative arabinose transporter; Provisional; Region: PRK03545 439855005046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855005047 putative substrate translocation pore; other site 439855005048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855005049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855005050 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 439855005051 putative dimerization interface [polypeptide binding]; other site 439855005052 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 439855005053 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 439855005054 NAD(P) binding site [chemical binding]; other site 439855005055 catalytic residues [active] 439855005056 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 439855005057 glutaminase; Provisional; Region: PRK00971 439855005058 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 439855005059 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855005060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005061 metal binding site [ion binding]; metal-binding site 439855005062 active site 439855005063 I-site; other site 439855005064 altronate oxidoreductase; Provisional; Region: PRK03643 439855005065 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 439855005066 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 439855005067 Predicted membrane protein [Function unknown]; Region: COG3781 439855005068 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 439855005069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855005070 S-adenosylmethionine binding site [chemical binding]; other site 439855005071 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 439855005072 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 439855005073 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 439855005074 putative active site; other site 439855005075 catalytic residue [active] 439855005076 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 439855005077 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 439855005078 ligand binding site [chemical binding]; other site 439855005079 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855005080 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855005081 TM-ABC transporter signature motif; other site 439855005082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855005083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855005084 TM-ABC transporter signature motif; other site 439855005085 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 439855005086 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855005087 Walker A/P-loop; other site 439855005088 ATP binding site [chemical binding]; other site 439855005089 Q-loop/lid; other site 439855005090 ABC transporter signature motif; other site 439855005091 Walker B; other site 439855005092 D-loop; other site 439855005093 H-loop/switch region; other site 439855005094 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855005095 transcriptional regulator LsrR; Provisional; Region: PRK15418 439855005096 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 439855005097 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 439855005098 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 439855005099 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 439855005100 putative N- and C-terminal domain interface [polypeptide binding]; other site 439855005101 putative active site [active] 439855005102 putative MgATP binding site [chemical binding]; other site 439855005103 catalytic site [active] 439855005104 metal binding site [ion binding]; metal-binding site 439855005105 putative carbohydrate binding site [chemical binding]; other site 439855005106 putative lipoprotein; Provisional; Region: PRK09707 439855005107 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 439855005108 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 439855005109 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 439855005110 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855005111 Fimbrial protein; Region: Fimbrial; cl01416 439855005112 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 439855005113 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855005114 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855005115 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 439855005116 PapC N-terminal domain; Region: PapC_N; pfam13954 439855005117 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855005118 PapC C-terminal domain; Region: PapC_C; pfam13953 439855005119 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855005120 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855005121 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855005122 HTH-like domain; Region: HTH_21; pfam13276 439855005123 Integrase core domain; Region: rve; pfam00665 439855005124 Integrase core domain; Region: rve_3; pfam13683 439855005125 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855005126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855005127 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 439855005128 mannosyl binding site [chemical binding]; other site 439855005129 Fimbrial protein; Region: Fimbrial; pfam00419 439855005130 putative oxidoreductase; Provisional; Region: PRK09939 439855005131 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 439855005132 putative molybdopterin cofactor binding site [chemical binding]; other site 439855005133 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 439855005134 putative molybdopterin cofactor binding site; other site 439855005135 transcriptional regulator YdeO; Provisional; Region: PRK09940 439855005136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855005137 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 439855005138 Sulfatase; Region: Sulfatase; pfam00884 439855005139 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 439855005140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855005141 FeS/SAM binding site; other site 439855005142 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 439855005143 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 439855005144 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 439855005145 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 439855005146 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 439855005147 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 439855005148 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 439855005149 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 439855005150 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 439855005151 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 439855005152 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 439855005153 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 439855005154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855005155 catalytic residue [active] 439855005156 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 439855005157 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 439855005158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 439855005159 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 439855005160 heme-binding site [chemical binding]; other site 439855005161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855005162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005163 metal binding site [ion binding]; metal-binding site 439855005164 active site 439855005165 I-site; other site 439855005166 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 439855005167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855005168 putative active site [active] 439855005169 heme pocket [chemical binding]; other site 439855005170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855005171 putative active site [active] 439855005172 heme pocket [chemical binding]; other site 439855005173 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005174 metal binding site [ion binding]; metal-binding site 439855005175 active site 439855005176 I-site; other site 439855005177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855005178 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 439855005179 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 439855005180 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 439855005181 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 439855005182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005183 dimer interface [polypeptide binding]; other site 439855005184 conserved gate region; other site 439855005185 putative PBP binding loops; other site 439855005186 ABC-ATPase subunit interface; other site 439855005187 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 439855005188 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 439855005189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005190 dimer interface [polypeptide binding]; other site 439855005191 conserved gate region; other site 439855005192 putative PBP binding loops; other site 439855005193 ABC-ATPase subunit interface; other site 439855005194 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 439855005195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855005196 Walker A/P-loop; other site 439855005197 ATP binding site [chemical binding]; other site 439855005198 Q-loop/lid; other site 439855005199 ABC transporter signature motif; other site 439855005200 Walker B; other site 439855005201 D-loop; other site 439855005202 H-loop/switch region; other site 439855005203 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 439855005204 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 439855005205 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855005206 Walker A/P-loop; other site 439855005207 ATP binding site [chemical binding]; other site 439855005208 Q-loop/lid; other site 439855005209 ABC transporter signature motif; other site 439855005210 Walker B; other site 439855005211 D-loop; other site 439855005212 H-loop/switch region; other site 439855005213 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 439855005214 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 439855005215 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 439855005216 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 439855005217 malate dehydrogenase; Provisional; Region: PRK13529 439855005218 Malic enzyme, N-terminal domain; Region: malic; pfam00390 439855005219 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 439855005220 NAD(P) binding site [chemical binding]; other site 439855005221 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 439855005222 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 439855005223 NAD binding site [chemical binding]; other site 439855005224 substrate binding site [chemical binding]; other site 439855005225 catalytic Zn binding site [ion binding]; other site 439855005226 tetramer interface [polypeptide binding]; other site 439855005227 structural Zn binding site [ion binding]; other site 439855005228 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 439855005229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855005230 non-specific DNA binding site [nucleotide binding]; other site 439855005231 salt bridge; other site 439855005232 sequence-specific DNA binding site [nucleotide binding]; other site 439855005233 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 439855005234 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 439855005235 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 439855005236 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 439855005237 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 439855005238 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 439855005239 [4Fe-4S] binding site [ion binding]; other site 439855005240 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005241 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 439855005242 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 439855005243 molybdopterin cofactor binding site; other site 439855005244 aromatic amino acid exporter; Provisional; Region: PRK11689 439855005245 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 439855005246 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 439855005247 trimer interface [polypeptide binding]; other site 439855005248 eyelet of channel; other site 439855005249 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 439855005250 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 439855005251 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 439855005252 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 439855005253 [4Fe-4S] binding site [ion binding]; other site 439855005254 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005255 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005256 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005257 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 439855005258 molybdopterin cofactor binding site; other site 439855005259 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 439855005260 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 439855005261 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 439855005262 hypothetical protein; Provisional; Region: PRK10281 439855005263 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 439855005264 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 439855005265 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 439855005266 active site 1 [active] 439855005267 dimer interface [polypeptide binding]; other site 439855005268 hexamer interface [polypeptide binding]; other site 439855005269 active site 2 [active] 439855005270 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 439855005271 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 439855005272 SCP-2 sterol transfer family; Region: SCP2; cl01225 439855005273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855005274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005275 metal binding site [ion binding]; metal-binding site 439855005276 active site 439855005277 I-site; other site 439855005278 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 439855005279 C-terminal domain interface [polypeptide binding]; other site 439855005280 GSH binding site (G-site) [chemical binding]; other site 439855005281 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 439855005282 dimer interface [polypeptide binding]; other site 439855005283 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 439855005284 N-terminal domain interface [polypeptide binding]; other site 439855005285 dimer interface [polypeptide binding]; other site 439855005286 substrate binding pocket (H-site) [chemical binding]; other site 439855005287 L-asparagine permease; Provisional; Region: PRK15049 439855005288 PQQ-like domain; Region: PQQ_2; pfam13360 439855005289 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 439855005290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855005291 N-terminal plug; other site 439855005292 ligand-binding site [chemical binding]; other site 439855005293 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 439855005294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855005295 DNA-binding site [nucleotide binding]; DNA binding site 439855005296 FCD domain; Region: FCD; pfam07729 439855005297 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 439855005298 Prostaglandin dehydrogenases; Region: PGDH; cd05288 439855005299 NAD(P) binding site [chemical binding]; other site 439855005300 substrate binding site [chemical binding]; other site 439855005301 dimer interface [polypeptide binding]; other site 439855005302 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 439855005303 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 439855005304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 439855005305 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 439855005306 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 439855005307 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 439855005308 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 439855005309 tetrameric interface [polypeptide binding]; other site 439855005310 NAD binding site [chemical binding]; other site 439855005311 catalytic residues [active] 439855005312 substrate binding site [chemical binding]; other site 439855005313 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 439855005314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005315 ABC-ATPase subunit interface; other site 439855005316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005317 dimer interface [polypeptide binding]; other site 439855005318 conserved gate region; other site 439855005319 putative PBP binding loops; other site 439855005320 ABC-ATPase subunit interface; other site 439855005321 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 439855005322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855005323 Walker A/P-loop; other site 439855005324 ATP binding site [chemical binding]; other site 439855005325 Q-loop/lid; other site 439855005326 ABC transporter signature motif; other site 439855005327 Walker B; other site 439855005328 D-loop; other site 439855005329 H-loop/switch region; other site 439855005330 TOBE domain; Region: TOBE_2; pfam08402 439855005331 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 439855005332 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 439855005333 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 439855005334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855005335 DNA-binding site [nucleotide binding]; DNA binding site 439855005336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855005337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855005338 homodimer interface [polypeptide binding]; other site 439855005339 catalytic residue [active] 439855005340 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 439855005341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855005342 sequence-specific DNA binding site [nucleotide binding]; other site 439855005343 salt bridge; other site 439855005344 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 439855005345 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 439855005346 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 439855005347 Peptidase family U32; Region: Peptidase_U32; pfam01136 439855005348 Collagenase; Region: DUF3656; pfam12392 439855005349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 439855005350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855005351 non-specific DNA binding site [nucleotide binding]; other site 439855005352 salt bridge; other site 439855005353 sequence-specific DNA binding site [nucleotide binding]; other site 439855005354 Cupin domain; Region: Cupin_2; pfam07883 439855005355 benzoate transporter; Region: benE; TIGR00843 439855005356 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 439855005357 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 439855005358 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 439855005359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855005360 benzoate transporter; Region: benE; TIGR00843 439855005361 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 439855005362 tellurite resistance protein TehB; Provisional; Region: PRK11207 439855005363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855005364 S-adenosylmethionine binding site [chemical binding]; other site 439855005365 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 439855005366 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 439855005367 gating phenylalanine in ion channel; other site 439855005368 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 439855005369 putative trimer interface [polypeptide binding]; other site 439855005370 putative CoA binding site [chemical binding]; other site 439855005371 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 439855005372 putative trimer interface [polypeptide binding]; other site 439855005373 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 439855005374 putative CoA binding site [chemical binding]; other site 439855005375 putative trimer interface [polypeptide binding]; other site 439855005376 putative CoA binding site [chemical binding]; other site 439855005377 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 439855005378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855005379 Coenzyme A binding pocket [chemical binding]; other site 439855005380 hypothetical protein; Provisional; Region: PRK11415 439855005381 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 439855005382 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 439855005383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 439855005384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 439855005385 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 439855005386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855005387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855005388 dimerization interface [polypeptide binding]; other site 439855005389 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 439855005390 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 439855005391 dimer interface [polypeptide binding]; other site 439855005392 ligand binding site [chemical binding]; other site 439855005393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855005394 dimerization interface [polypeptide binding]; other site 439855005395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 439855005396 dimer interface [polypeptide binding]; other site 439855005397 putative CheW interface [polypeptide binding]; other site 439855005398 hypothetical protein; Provisional; Region: PRK10040 439855005399 cytochrome b561; Provisional; Region: PRK11513 439855005400 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 439855005401 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 439855005402 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 439855005403 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 439855005404 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 439855005405 NAD binding site [chemical binding]; other site 439855005406 catalytic residues [active] 439855005407 substrate binding site [chemical binding]; other site 439855005408 Uncharacterized conserved protein [Function unknown]; Region: COG1434 439855005409 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 439855005410 putative active site [active] 439855005411 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 439855005412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855005413 ATP binding site [chemical binding]; other site 439855005414 putative Mg++ binding site [ion binding]; other site 439855005415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855005416 nucleotide binding region [chemical binding]; other site 439855005417 ATP-binding site [chemical binding]; other site 439855005418 Helicase associated domain (HA2); Region: HA2; pfam04408 439855005419 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 439855005420 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 439855005421 azoreductase; Reviewed; Region: PRK00170 439855005422 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 439855005423 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 439855005424 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 439855005425 active site 439855005426 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 439855005427 active site 439855005428 catalytic residues [active] 439855005429 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 439855005430 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 439855005431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855005432 S-adenosylmethionine binding site [chemical binding]; other site 439855005433 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 439855005434 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 439855005435 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 439855005436 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 439855005437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855005438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855005439 active site 439855005440 catalytic tetrad [active] 439855005441 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855005442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 439855005443 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 439855005444 hypothetical protein; Provisional; Region: PRK10695 439855005445 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 439855005446 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 439855005447 putative ligand binding site [chemical binding]; other site 439855005448 putative NAD binding site [chemical binding]; other site 439855005449 catalytic site [active] 439855005450 heat-inducible protein; Provisional; Region: PRK10449 439855005451 Domain of unknown function (DUF333); Region: DUF333; pfam03891 439855005452 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 439855005453 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 439855005454 dimer interface [polypeptide binding]; other site 439855005455 PYR/PP interface [polypeptide binding]; other site 439855005456 TPP binding site [chemical binding]; other site 439855005457 substrate binding site [chemical binding]; other site 439855005458 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 439855005459 Domain of unknown function; Region: EKR; smart00890 439855005460 4Fe-4S binding domain; Region: Fer4_6; pfam12837 439855005461 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855005462 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 439855005463 TPP-binding site [chemical binding]; other site 439855005464 dimer interface [polypeptide binding]; other site 439855005465 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 439855005466 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 439855005467 trimer interface [polypeptide binding]; other site 439855005468 eyelet of channel; other site 439855005469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855005470 Ligand Binding Site [chemical binding]; other site 439855005471 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 439855005472 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 439855005473 Ligand Binding Site [chemical binding]; other site 439855005474 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 439855005475 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 439855005476 ATP binding site [chemical binding]; other site 439855005477 Mg++ binding site [ion binding]; other site 439855005478 motif III; other site 439855005479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855005480 nucleotide binding region [chemical binding]; other site 439855005481 ATP-binding site [chemical binding]; other site 439855005482 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 439855005483 putative RNA binding site [nucleotide binding]; other site 439855005484 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 439855005485 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 439855005486 Cl binding site [ion binding]; other site 439855005487 oligomer interface [polypeptide binding]; other site 439855005488 PAS domain S-box; Region: sensory_box; TIGR00229 439855005489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855005490 putative active site [active] 439855005491 heme pocket [chemical binding]; other site 439855005492 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855005493 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005494 metal binding site [ion binding]; metal-binding site 439855005495 active site 439855005496 I-site; other site 439855005497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 439855005498 Smr domain; Region: Smr; pfam01713 439855005499 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 439855005500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855005501 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 439855005502 putative substrate binding pocket [chemical binding]; other site 439855005503 putative dimerization interface [polypeptide binding]; other site 439855005504 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 439855005505 amidohydrolase; Region: amidohydrolases; TIGR01891 439855005506 putative metal binding site [ion binding]; other site 439855005507 dimer interface [polypeptide binding]; other site 439855005508 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 439855005509 amidohydrolase; Region: amidohydrolases; TIGR01891 439855005510 putative metal binding site [ion binding]; other site 439855005511 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 439855005512 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 439855005513 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 439855005514 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 439855005515 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 439855005516 DNA binding site [nucleotide binding] 439855005517 active site 439855005518 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 439855005519 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 439855005520 ligand binding site [chemical binding]; other site 439855005521 flexible hinge region; other site 439855005522 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 439855005523 putative switch regulator; other site 439855005524 non-specific DNA interactions [nucleotide binding]; other site 439855005525 DNA binding site [nucleotide binding] 439855005526 sequence specific DNA binding site [nucleotide binding]; other site 439855005527 putative cAMP binding site [chemical binding]; other site 439855005528 universal stress protein UspE; Provisional; Region: PRK11175 439855005529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855005530 Ligand Binding Site [chemical binding]; other site 439855005531 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855005532 Ligand Binding Site [chemical binding]; other site 439855005533 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 439855005534 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 439855005535 Mechanosensitive ion channel; Region: MS_channel; pfam00924 439855005536 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 439855005537 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 439855005538 peptide binding site [polypeptide binding]; other site 439855005539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855005540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855005541 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 439855005542 putative effector binding pocket; other site 439855005543 putative dimerization interface [polypeptide binding]; other site 439855005544 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 439855005545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 439855005546 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 439855005547 NADH(P)-binding; Region: NAD_binding_10; pfam13460 439855005548 putative NAD(P) binding site [chemical binding]; other site 439855005549 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 439855005550 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 439855005551 putative active site [active] 439855005552 Zn binding site [ion binding]; other site 439855005553 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 439855005554 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 439855005555 active site 439855005556 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 439855005557 dimer interface [polypeptide binding]; other site 439855005558 catalytic triad [active] 439855005559 peroxidatic and resolving cysteines [active] 439855005560 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 439855005561 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 439855005562 putative aromatic amino acid binding site; other site 439855005563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855005564 Walker A motif; other site 439855005565 ATP binding site [chemical binding]; other site 439855005566 Walker B motif; other site 439855005567 arginine finger; other site 439855005568 hypothetical protein; Provisional; Region: PRK05415 439855005569 TIGR01620 family protein; Region: hyp_HI0043 439855005570 Predicted ATPase [General function prediction only]; Region: COG3106 439855005571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 439855005572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855005573 DNA binding site [nucleotide binding] 439855005574 domain linker motif; other site 439855005575 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 439855005576 putative dimerization interface [polypeptide binding]; other site 439855005577 putative ligand binding site [chemical binding]; other site 439855005578 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 439855005579 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 439855005580 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 439855005581 Walker A/P-loop; other site 439855005582 ATP binding site [chemical binding]; other site 439855005583 Q-loop/lid; other site 439855005584 ABC transporter signature motif; other site 439855005585 Walker B; other site 439855005586 D-loop; other site 439855005587 H-loop/switch region; other site 439855005588 TOBE domain; Region: TOBE_2; pfam08402 439855005589 beta-phosphoglucomutase; Region: bPGM; TIGR01990 439855005590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855005591 motif II; other site 439855005592 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 439855005593 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 439855005594 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 439855005595 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 439855005596 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 439855005597 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 439855005598 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 439855005599 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 439855005600 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855005601 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 439855005602 putative NAD(P) binding site [chemical binding]; other site 439855005603 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 439855005604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005605 dimer interface [polypeptide binding]; other site 439855005606 conserved gate region; other site 439855005607 putative PBP binding loops; other site 439855005608 ABC-ATPase subunit interface; other site 439855005609 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 439855005610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005611 dimer interface [polypeptide binding]; other site 439855005612 conserved gate region; other site 439855005613 putative PBP binding loops; other site 439855005614 ABC-ATPase subunit interface; other site 439855005615 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 439855005616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 439855005617 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 439855005618 sucrose phosphorylase; Provisional; Region: PRK13840 439855005619 active site 439855005620 homodimer interface [polypeptide binding]; other site 439855005621 catalytic site [active] 439855005622 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 439855005623 active site residue [active] 439855005624 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 439855005625 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 439855005626 phage shock protein C; Region: phageshock_pspC; TIGR02978 439855005627 phage shock protein B; Provisional; Region: pspB; PRK09458 439855005628 phage shock protein PspA; Provisional; Region: PRK10698 439855005629 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 439855005630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855005631 Walker A motif; other site 439855005632 ATP binding site [chemical binding]; other site 439855005633 Walker B motif; other site 439855005634 arginine finger; other site 439855005635 4-aminobutyrate transaminase; Provisional; Region: PRK09792 439855005636 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855005637 inhibitor-cofactor binding pocket; inhibition site 439855005638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855005639 catalytic residue [active] 439855005640 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 439855005641 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 439855005642 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 439855005643 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 439855005644 NAD(P) binding site [chemical binding]; other site 439855005645 catalytic residues [active] 439855005646 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 439855005647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855005648 non-specific DNA binding site [nucleotide binding]; other site 439855005649 salt bridge; other site 439855005650 sequence-specific DNA binding site [nucleotide binding]; other site 439855005651 Cupin domain; Region: Cupin_2; pfam07883 439855005652 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 439855005653 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 439855005654 catalytic triad [active] 439855005655 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 439855005656 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 439855005657 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 439855005658 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 439855005659 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 439855005660 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 439855005661 peptide binding site [polypeptide binding]; other site 439855005662 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 439855005663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005664 dimer interface [polypeptide binding]; other site 439855005665 conserved gate region; other site 439855005666 putative PBP binding loops; other site 439855005667 ABC-ATPase subunit interface; other site 439855005668 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 439855005669 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 439855005670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005671 dimer interface [polypeptide binding]; other site 439855005672 conserved gate region; other site 439855005673 putative PBP binding loops; other site 439855005674 ABC-ATPase subunit interface; other site 439855005675 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 439855005676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855005677 Walker A/P-loop; other site 439855005678 ATP binding site [chemical binding]; other site 439855005679 Q-loop/lid; other site 439855005680 ABC transporter signature motif; other site 439855005681 Walker B; other site 439855005682 D-loop; other site 439855005683 H-loop/switch region; other site 439855005684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 439855005685 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 439855005686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855005687 Walker A/P-loop; other site 439855005688 ATP binding site [chemical binding]; other site 439855005689 Q-loop/lid; other site 439855005690 ABC transporter signature motif; other site 439855005691 Walker B; other site 439855005692 D-loop; other site 439855005693 H-loop/switch region; other site 439855005694 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 439855005695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855005696 putative substrate translocation pore; other site 439855005697 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 439855005698 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 439855005699 Protein export membrane protein; Region: SecD_SecF; cl14618 439855005700 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 439855005701 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855005702 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855005703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 439855005704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855005705 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 439855005706 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 439855005707 NAD binding site [chemical binding]; other site 439855005708 homotetramer interface [polypeptide binding]; other site 439855005709 homodimer interface [polypeptide binding]; other site 439855005710 substrate binding site [chemical binding]; other site 439855005711 active site 439855005712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 439855005713 Uncharacterized conserved protein [Function unknown]; Region: COG2128 439855005714 exoribonuclease II; Provisional; Region: PRK05054 439855005715 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 439855005716 RNB domain; Region: RNB; pfam00773 439855005717 S1 RNA binding domain; Region: S1; pfam00575 439855005718 RNase II stability modulator; Provisional; Region: PRK10060 439855005719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855005720 putative active site [active] 439855005721 heme pocket [chemical binding]; other site 439855005722 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855005723 metal binding site [ion binding]; metal-binding site 439855005724 active site 439855005725 I-site; other site 439855005726 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855005727 hypothetical protein; Provisional; Region: PRK13658 439855005728 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 439855005729 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 439855005730 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855005731 lipoprotein; Provisional; Region: PRK10540 439855005732 translation initiation factor Sui1; Validated; Region: PRK06824 439855005733 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 439855005734 putative rRNA binding site [nucleotide binding]; other site 439855005735 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 439855005736 active site 439855005737 dimer interface [polypeptide binding]; other site 439855005738 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 439855005739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 439855005740 TPR motif; other site 439855005741 binding surface 439855005742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855005743 binding surface 439855005744 TPR motif; other site 439855005745 Predicted membrane protein [Function unknown]; Region: COG3771 439855005746 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 439855005747 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 439855005748 active site 439855005749 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 439855005750 dimerization interface [polypeptide binding]; other site 439855005751 active site 439855005752 aconitate hydratase; Validated; Region: PRK09277 439855005753 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 439855005754 substrate binding site [chemical binding]; other site 439855005755 ligand binding site [chemical binding]; other site 439855005756 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 439855005757 substrate binding site [chemical binding]; other site 439855005758 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 439855005759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855005760 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 439855005761 substrate binding site [chemical binding]; other site 439855005762 putative dimerization interface [polypeptide binding]; other site 439855005763 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 439855005764 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 439855005765 active site 439855005766 interdomain interaction site; other site 439855005767 putative metal-binding site [ion binding]; other site 439855005768 nucleotide binding site [chemical binding]; other site 439855005769 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 439855005770 domain I; other site 439855005771 DNA binding groove [nucleotide binding] 439855005772 phosphate binding site [ion binding]; other site 439855005773 domain II; other site 439855005774 domain III; other site 439855005775 nucleotide binding site [chemical binding]; other site 439855005776 catalytic site [active] 439855005777 domain IV; other site 439855005778 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 439855005779 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 439855005780 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 439855005781 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 439855005782 hypothetical protein; Provisional; Region: PRK11037 439855005783 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 439855005784 putative inner membrane peptidase; Provisional; Region: PRK11778 439855005785 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 439855005786 tandem repeat interface [polypeptide binding]; other site 439855005787 oligomer interface [polypeptide binding]; other site 439855005788 active site residues [active] 439855005789 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 439855005790 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 439855005791 NADP binding site [chemical binding]; other site 439855005792 homodimer interface [polypeptide binding]; other site 439855005793 active site 439855005794 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 439855005795 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 439855005796 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 439855005797 homodimer interface [polypeptide binding]; other site 439855005798 Walker A motif; other site 439855005799 ATP binding site [chemical binding]; other site 439855005800 hydroxycobalamin binding site [chemical binding]; other site 439855005801 Walker B motif; other site 439855005802 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 439855005803 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 439855005804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855005805 RNA binding surface [nucleotide binding]; other site 439855005806 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 439855005807 probable active site [active] 439855005808 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 439855005809 hypothetical protein; Provisional; Region: PRK11630 439855005810 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 439855005811 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 439855005812 active site 439855005813 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 439855005814 anthranilate synthase component I; Provisional; Region: PRK13564 439855005815 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 439855005816 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 439855005817 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 439855005818 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 439855005819 glutamine binding [chemical binding]; other site 439855005820 catalytic triad [active] 439855005821 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 439855005822 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 439855005823 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 439855005824 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 439855005825 active site 439855005826 ribulose/triose binding site [chemical binding]; other site 439855005827 phosphate binding site [ion binding]; other site 439855005828 substrate (anthranilate) binding pocket [chemical binding]; other site 439855005829 product (indole) binding pocket [chemical binding]; other site 439855005830 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 439855005831 active site 439855005832 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 439855005833 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 439855005834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855005835 catalytic residue [active] 439855005836 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 439855005837 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 439855005838 substrate binding site [chemical binding]; other site 439855005839 active site 439855005840 catalytic residues [active] 439855005841 heterodimer interface [polypeptide binding]; other site 439855005842 General stress protein [General function prediction only]; Region: GsiB; COG3729 439855005843 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 439855005844 dimerization interface [polypeptide binding]; other site 439855005845 metal binding site [ion binding]; metal-binding site 439855005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 439855005847 outer membrane protein W; Provisional; Region: PRK10959 439855005848 hypothetical protein; Provisional; Region: PRK02868 439855005849 intracellular septation protein A; Reviewed; Region: PRK00259 439855005850 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 439855005851 transport protein TonB; Provisional; Region: PRK10819 439855005852 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 439855005853 YciI-like protein; Reviewed; Region: PRK11370 439855005854 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 439855005855 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 439855005856 Sulfatase; Region: Sulfatase; cl17466 439855005857 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 439855005858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855005859 HTH-like domain; Region: HTH_21; pfam13276 439855005860 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855005861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855005862 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855005863 HTH-like domain; Region: HTH_21; pfam13276 439855005864 Integrase core domain; Region: rve; pfam00665 439855005865 Integrase core domain; Region: rve_3; pfam13683 439855005866 Integrase core domain; Region: rve; pfam00665 439855005867 DDE domain; Region: DDE_Tnp_IS240; pfam13610 439855005868 Integrase core domain; Region: rve_3; pfam13683 439855005869 voltage-gated potassium channel; Provisional; Region: PRK10537 439855005870 Ion channel; Region: Ion_trans_2; pfam07885 439855005871 TrkA-N domain; Region: TrkA_N; pfam02254 439855005872 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 439855005873 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 439855005874 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 439855005875 putative active site [active] 439855005876 catalytic site [active] 439855005877 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 439855005878 putative active site [active] 439855005879 catalytic site [active] 439855005880 dsDNA-mimic protein; Reviewed; Region: PRK05094 439855005881 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 439855005882 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855005883 Walker A/P-loop; other site 439855005884 ATP binding site [chemical binding]; other site 439855005885 Q-loop/lid; other site 439855005886 ABC transporter signature motif; other site 439855005887 Walker B; other site 439855005888 D-loop; other site 439855005889 H-loop/switch region; other site 439855005890 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 439855005891 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 439855005892 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855005893 Walker A/P-loop; other site 439855005894 ATP binding site [chemical binding]; other site 439855005895 Q-loop/lid; other site 439855005896 ABC transporter signature motif; other site 439855005897 Walker B; other site 439855005898 D-loop; other site 439855005899 H-loop/switch region; other site 439855005900 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 439855005901 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 439855005902 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 439855005903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005904 dimer interface [polypeptide binding]; other site 439855005905 conserved gate region; other site 439855005906 putative PBP binding loops; other site 439855005907 ABC-ATPase subunit interface; other site 439855005908 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 439855005909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855005910 dimer interface [polypeptide binding]; other site 439855005911 conserved gate region; other site 439855005912 putative PBP binding loops; other site 439855005913 ABC-ATPase subunit interface; other site 439855005914 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 439855005915 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 439855005916 peptide binding site [polypeptide binding]; other site 439855005917 hypothetical protein; Provisional; Region: PRK11111 439855005918 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 439855005919 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 439855005920 putative catalytic cysteine [active] 439855005921 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 439855005922 putative active site [active] 439855005923 metal binding site [ion binding]; metal-binding site 439855005924 thymidine kinase; Provisional; Region: PRK04296 439855005925 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 439855005926 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 439855005927 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 439855005928 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 439855005929 active site 439855005930 tetramer interface; other site 439855005931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855005932 active site 439855005933 response regulator of RpoS; Provisional; Region: PRK10693 439855005934 phosphorylation site [posttranslational modification] 439855005935 intermolecular recognition site; other site 439855005936 dimerization interface [polypeptide binding]; other site 439855005937 hypothetical protein; Provisional; Region: PRK10279 439855005938 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 439855005939 active site 439855005940 nucleophile elbow; other site 439855005941 SEC-C motif; Region: SEC-C; pfam02810 439855005942 hypothetical protein; Provisional; Region: PRK04233 439855005943 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 439855005944 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 439855005945 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 439855005946 putative active site [active] 439855005947 putative substrate binding site [chemical binding]; other site 439855005948 putative cosubstrate binding site; other site 439855005949 catalytic site [active] 439855005950 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 439855005951 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 439855005952 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 439855005953 4Fe-4S binding domain; Region: Fer4; cl02805 439855005954 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 439855005955 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 439855005956 [4Fe-4S] binding site [ion binding]; other site 439855005957 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005958 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005959 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855005960 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 439855005961 molybdopterin cofactor binding site; other site 439855005962 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 439855005963 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 439855005964 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 439855005965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855005966 dimerization interface [polypeptide binding]; other site 439855005967 Histidine kinase; Region: HisKA_3; pfam07730 439855005968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855005969 ATP binding site [chemical binding]; other site 439855005970 Mg2+ binding site [ion binding]; other site 439855005971 G-X-G motif; other site 439855005972 transcriptional regulator NarL; Provisional; Region: PRK10651 439855005973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855005974 active site 439855005975 phosphorylation site [posttranslational modification] 439855005976 intermolecular recognition site; other site 439855005977 dimerization interface [polypeptide binding]; other site 439855005978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855005979 DNA binding residues [nucleotide binding] 439855005980 dimerization interface [polypeptide binding]; other site 439855005981 putative invasin; Provisional; Region: PRK10177 439855005982 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 439855005983 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 439855005984 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 439855005985 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 439855005986 putative active site pocket [active] 439855005987 dimerization interface [polypeptide binding]; other site 439855005988 putative catalytic residue [active] 439855005989 cation transport regulator; Reviewed; Region: chaB; PRK09582 439855005990 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 439855005991 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 439855005992 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855005993 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855005994 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 439855005995 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 439855005996 hypothetical protein; Provisional; Region: PRK10941 439855005997 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 439855005998 hypothetical protein; Provisional; Region: PRK10278 439855005999 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 439855006000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855006001 peptide chain release factor 1; Validated; Region: prfA; PRK00591 439855006002 This domain is found in peptide chain release factors; Region: PCRF; smart00937 439855006003 RF-1 domain; Region: RF-1; pfam00472 439855006004 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 439855006005 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 439855006006 tRNA; other site 439855006007 putative tRNA binding site [nucleotide binding]; other site 439855006008 putative NADP binding site [chemical binding]; other site 439855006009 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 439855006010 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 439855006011 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 439855006012 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 439855006013 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 439855006014 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 439855006015 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 439855006016 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 439855006017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855006018 active site 439855006019 putative transporter; Provisional; Region: PRK11660 439855006020 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 439855006021 Sulfate transporter family; Region: Sulfate_transp; pfam00916 439855006022 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 439855006023 hypothetical protein; Provisional; Region: PRK10692 439855006024 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 439855006025 putative active site [active] 439855006026 catalytic residue [active] 439855006027 GTP-binding protein YchF; Reviewed; Region: PRK09601 439855006028 YchF GTPase; Region: YchF; cd01900 439855006029 G1 box; other site 439855006030 GTP/Mg2+ binding site [chemical binding]; other site 439855006031 Switch I region; other site 439855006032 G2 box; other site 439855006033 Switch II region; other site 439855006034 G3 box; other site 439855006035 G4 box; other site 439855006036 G5 box; other site 439855006037 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 439855006038 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 439855006039 PAS domain; Region: PAS; smart00091 439855006040 putative active site [active] 439855006041 heme pocket [chemical binding]; other site 439855006042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855006043 Walker A motif; other site 439855006044 ATP binding site [chemical binding]; other site 439855006045 Walker B motif; other site 439855006046 arginine finger; other site 439855006047 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855006048 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 439855006049 Dak1 domain; Region: Dak1; pfam02733 439855006050 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 439855006051 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 439855006052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 439855006053 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855006054 dimerization domain swap beta strand [polypeptide binding]; other site 439855006055 regulatory protein interface [polypeptide binding]; other site 439855006056 active site 439855006057 regulatory phosphorylation site [posttranslational modification]; other site 439855006058 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 439855006059 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855006060 trehalase; Provisional; Region: treA; PRK13271 439855006061 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 439855006062 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 439855006063 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 439855006064 putative metal binding site [ion binding]; other site 439855006065 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 439855006066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855006067 ABC-ATPase subunit interface; other site 439855006068 dimer interface [polypeptide binding]; other site 439855006069 putative PBP binding regions; other site 439855006070 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 439855006071 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 439855006072 Walker A/P-loop; other site 439855006073 ATP binding site [chemical binding]; other site 439855006074 Q-loop/lid; other site 439855006075 ABC transporter signature motif; other site 439855006076 Walker B; other site 439855006077 D-loop; other site 439855006078 H-loop/switch region; other site 439855006079 Methyltransferase domain; Region: Methyltransf_31; pfam13847 439855006080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855006081 S-adenosylmethionine binding site [chemical binding]; other site 439855006082 molybdenum transport protein ModD; Provisional; Region: PRK06096 439855006083 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 439855006084 dimerization interface [polypeptide binding]; other site 439855006085 active site 439855006086 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855006087 N-terminal plug; other site 439855006088 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 439855006089 ligand-binding site [chemical binding]; other site 439855006090 hypothetical protein; Provisional; Region: PRK10457 439855006091 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 439855006092 Flagellar regulator YcgR; Region: YcgR; pfam07317 439855006093 PilZ domain; Region: PilZ; pfam07238 439855006094 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 439855006095 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855006096 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855006097 catalytic residue [active] 439855006098 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 439855006099 dimer interface [polypeptide binding]; other site 439855006100 catalytic triad [active] 439855006101 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 439855006102 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 439855006103 TrkA-C domain; Region: TrkA_C; pfam02080 439855006104 Transporter associated domain; Region: CorC_HlyC; smart01091 439855006105 Leucine rich repeat; Region: LRR_8; pfam13855 439855006106 alanine racemase; Reviewed; Region: dadX; PRK03646 439855006107 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 439855006108 active site 439855006109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855006110 substrate binding site [chemical binding]; other site 439855006111 catalytic residues [active] 439855006112 dimer interface [polypeptide binding]; other site 439855006113 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 439855006114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855006115 SpoVR family protein; Provisional; Region: PRK11767 439855006116 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 439855006117 fatty acid metabolism regulator; Provisional; Region: PRK04984 439855006118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855006119 DNA-binding site [nucleotide binding]; DNA binding site 439855006120 FadR C-terminal domain; Region: FadR_C; pfam07840 439855006121 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 439855006122 transmembrane helices; other site 439855006123 disulfide bond formation protein B; Provisional; Region: PRK01749 439855006124 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 439855006125 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 439855006126 active site 439855006127 DNA binding site [nucleotide binding] 439855006128 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 439855006129 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 439855006130 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 439855006131 Catalytic site [active] 439855006132 hemolysin E; Provisional; Region: hlyE; PRK11376 439855006133 hypothetical protein; Provisional; Region: PRK05170 439855006134 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 439855006135 hypothetical protein; Provisional; Region: PRK10691 439855006136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 439855006137 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 439855006138 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 439855006139 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 439855006140 septum formation inhibitor; Reviewed; Region: minC; PRK03511 439855006141 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 439855006142 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 439855006143 cell division inhibitor MinD; Provisional; Region: PRK10818 439855006144 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 439855006145 Switch I; other site 439855006146 Switch II; other site 439855006147 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 439855006148 Autotransporter beta-domain; Region: Autotransporter; cl17461 439855006149 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 439855006150 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 439855006151 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855006152 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 439855006153 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855006154 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 439855006155 Sensors of blue-light using FAD; Region: BLUF; smart01034 439855006156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855006157 transcriptional regulator MirA; Provisional; Region: PRK15043 439855006158 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 439855006159 DNA binding residues [nucleotide binding] 439855006160 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 439855006161 isocitrate dehydrogenase; Validated; Region: PRK07362 439855006162 isocitrate dehydrogenase; Reviewed; Region: PRK07006 439855006163 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 439855006164 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 439855006165 probable active site [active] 439855006166 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 439855006167 nudix motif; other site 439855006168 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 439855006169 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 439855006170 putative lysogenization regulator; Reviewed; Region: PRK00218 439855006171 adenylosuccinate lyase; Provisional; Region: PRK09285 439855006172 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 439855006173 tetramer interface [polypeptide binding]; other site 439855006174 active site 439855006175 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 439855006176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855006177 active site 439855006178 phosphorylation site [posttranslational modification] 439855006179 intermolecular recognition site; other site 439855006180 dimerization interface [polypeptide binding]; other site 439855006181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855006182 DNA binding site [nucleotide binding] 439855006183 sensor protein PhoQ; Provisional; Region: PRK10815 439855006184 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 439855006185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 439855006186 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 439855006187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855006188 ATP binding site [chemical binding]; other site 439855006189 Mg2+ binding site [ion binding]; other site 439855006190 G-X-G motif; other site 439855006191 Uncharacterized conserved protein [Function unknown]; Region: COG2850 439855006192 Cupin-like domain; Region: Cupin_8; pfam13621 439855006193 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 439855006194 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 439855006195 metal binding site [ion binding]; metal-binding site 439855006196 dimer interface [polypeptide binding]; other site 439855006197 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 439855006198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855006199 Walker A/P-loop; other site 439855006200 ATP binding site [chemical binding]; other site 439855006201 Q-loop/lid; other site 439855006202 ABC transporter signature motif; other site 439855006203 Walker B; other site 439855006204 D-loop; other site 439855006205 H-loop/switch region; other site 439855006206 TOBE domain; Region: TOBE_2; pfam08402 439855006207 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 439855006208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855006209 dimer interface [polypeptide binding]; other site 439855006210 conserved gate region; other site 439855006211 putative PBP binding loops; other site 439855006212 ABC-ATPase subunit interface; other site 439855006213 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 439855006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855006215 dimer interface [polypeptide binding]; other site 439855006216 conserved gate region; other site 439855006217 putative PBP binding loops; other site 439855006218 ABC-ATPase subunit interface; other site 439855006219 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 439855006220 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 439855006221 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 439855006222 NAD-dependent deacetylase; Provisional; Region: PRK00481 439855006223 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 439855006224 NAD+ binding site [chemical binding]; other site 439855006225 substrate binding site [chemical binding]; other site 439855006226 Zn binding site [ion binding]; other site 439855006227 fructokinase; Reviewed; Region: PRK09557 439855006228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855006229 nucleotide binding site [chemical binding]; other site 439855006230 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 439855006231 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 439855006232 FtsX-like permease family; Region: FtsX; pfam02687 439855006233 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 439855006234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 439855006235 Walker A/P-loop; other site 439855006236 ATP binding site [chemical binding]; other site 439855006237 Q-loop/lid; other site 439855006238 ABC transporter signature motif; other site 439855006239 Walker B; other site 439855006240 D-loop; other site 439855006241 H-loop/switch region; other site 439855006242 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 439855006243 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 439855006244 FtsX-like permease family; Region: FtsX; pfam02687 439855006245 Predicted membrane protein [Function unknown]; Region: COG4763 439855006246 Acyltransferase family; Region: Acyl_transf_3; pfam01757 439855006247 transcription-repair coupling factor; Provisional; Region: PRK10689 439855006248 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 439855006249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855006250 ATP binding site [chemical binding]; other site 439855006251 putative Mg++ binding site [ion binding]; other site 439855006252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855006253 nucleotide binding region [chemical binding]; other site 439855006254 ATP-binding site [chemical binding]; other site 439855006255 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 439855006256 L,D-transpeptidase; Provisional; Region: PRK10260 439855006257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855006258 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855006259 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855006260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 439855006261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855006262 hypothetical protein; Provisional; Region: PRK11280 439855006263 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 439855006264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855006265 hypothetical protein; Provisional; Region: PRK04940 439855006266 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 439855006267 beta-hexosaminidase; Provisional; Region: PRK05337 439855006268 thiamine kinase; Region: ycfN_thiK; TIGR02721 439855006269 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 439855006270 active site 439855006271 substrate binding site [chemical binding]; other site 439855006272 ATP binding site [chemical binding]; other site 439855006273 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 439855006274 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 439855006275 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 439855006276 putative dimer interface [polypeptide binding]; other site 439855006277 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 439855006278 nucleotide binding site/active site [active] 439855006279 HIT family signature motif; other site 439855006280 catalytic residue [active] 439855006281 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 439855006282 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855006283 N-terminal plug; other site 439855006284 ligand-binding site [chemical binding]; other site 439855006285 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 439855006286 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 439855006287 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855006288 active site turn [active] 439855006289 phosphorylation site [posttranslational modification] 439855006290 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 439855006291 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 439855006292 active site 439855006293 DNA polymerase III subunit delta'; Validated; Region: PRK07993 439855006294 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 439855006295 thymidylate kinase; Validated; Region: tmk; PRK00698 439855006296 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 439855006297 TMP-binding site; other site 439855006298 ATP-binding site [chemical binding]; other site 439855006299 conserved hypothetical protein, YceG family; Region: TIGR00247 439855006300 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 439855006301 dimerization interface [polypeptide binding]; other site 439855006302 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 439855006303 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 439855006304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855006305 catalytic residue [active] 439855006306 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 439855006307 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 439855006308 dimer interface [polypeptide binding]; other site 439855006309 active site 439855006310 acyl carrier protein; Provisional; Region: acpP; PRK00982 439855006311 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 439855006312 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 439855006313 NAD(P) binding site [chemical binding]; other site 439855006314 homotetramer interface [polypeptide binding]; other site 439855006315 homodimer interface [polypeptide binding]; other site 439855006316 active site 439855006317 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 439855006318 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 439855006319 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 439855006320 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 439855006321 dimer interface [polypeptide binding]; other site 439855006322 active site 439855006323 CoA binding pocket [chemical binding]; other site 439855006324 putative phosphate acyltransferase; Provisional; Region: PRK05331 439855006325 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 439855006326 hypothetical protein; Provisional; Region: PRK11193 439855006327 Maf-like protein; Region: Maf; pfam02545 439855006328 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 439855006329 active site 439855006330 dimer interface [polypeptide binding]; other site 439855006331 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 439855006332 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855006333 RNA binding surface [nucleotide binding]; other site 439855006334 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 439855006335 active site 439855006336 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 439855006337 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 439855006338 homodimer interface [polypeptide binding]; other site 439855006339 oligonucleotide binding site [chemical binding]; other site 439855006340 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 439855006341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 439855006342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855006343 Coenzyme A binding pocket [chemical binding]; other site 439855006344 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 439855006345 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 439855006346 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 439855006347 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855006348 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 439855006349 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 439855006350 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 439855006351 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 439855006352 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 439855006353 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 439855006354 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 439855006355 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 439855006356 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 439855006357 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855006358 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855006359 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 439855006360 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855006361 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 439855006362 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 439855006363 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855006364 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 439855006365 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855006366 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 439855006367 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 439855006368 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 439855006369 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 439855006370 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 439855006371 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 439855006372 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 439855006373 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 439855006374 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 439855006375 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 439855006376 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 439855006377 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 439855006378 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 439855006379 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 439855006380 MviN-like protein; Region: MVIN; pfam03023 439855006381 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 439855006382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 439855006383 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 439855006384 hypothetical protein; Provisional; Region: PRK11239 439855006385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 439855006386 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 439855006387 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 439855006388 multidrug resistance protein MdtH; Provisional; Region: PRK11646 439855006389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855006390 putative substrate translocation pore; other site 439855006391 glutaredoxin 2; Provisional; Region: PRK10387 439855006392 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 439855006393 C-terminal domain interface [polypeptide binding]; other site 439855006394 GSH binding site (G-site) [chemical binding]; other site 439855006395 catalytic residues [active] 439855006396 putative dimer interface [polypeptide binding]; other site 439855006397 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 439855006398 N-terminal domain interface [polypeptide binding]; other site 439855006399 lipoprotein; Provisional; Region: PRK10598 439855006400 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 439855006401 active site 439855006402 substrate binding pocket [chemical binding]; other site 439855006403 dimer interface [polypeptide binding]; other site 439855006404 DNA damage-inducible protein I; Provisional; Region: PRK10597 439855006405 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 439855006406 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 439855006407 hydroxyglutarate oxidase; Provisional; Region: PRK11728 439855006408 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 439855006409 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 439855006410 hypothetical protein; Provisional; Region: PRK03757 439855006411 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 439855006412 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 439855006413 active site residue [active] 439855006414 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 439855006415 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 439855006416 putative acyl-acceptor binding pocket; other site 439855006417 drug efflux system protein MdtG; Provisional; Region: PRK09874 439855006418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855006419 putative substrate translocation pore; other site 439855006420 secY/secA suppressor protein; Provisional; Region: PRK11467 439855006421 lipoprotein; Provisional; Region: PRK10175 439855006422 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 439855006423 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 439855006424 Ligand binding site; other site 439855006425 DXD motif; other site 439855006426 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 439855006427 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 439855006428 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 439855006429 Acyltransferase family; Region: Acyl_transf_3; pfam01757 439855006430 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 439855006431 PLD-like domain; Region: PLDc_2; pfam13091 439855006432 putative active site [active] 439855006433 catalytic site [active] 439855006434 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 439855006435 PLD-like domain; Region: PLDc_2; pfam13091 439855006436 putative active site [active] 439855006437 catalytic site [active] 439855006438 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 439855006439 putative ADP-ribose binding site [chemical binding]; other site 439855006440 putative active site [active] 439855006441 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 439855006442 major curlin subunit; Provisional; Region: csgA; PRK10051 439855006443 Curlin associated repeat; Region: Curlin_rpt; pfam07012 439855006444 Curlin associated repeat; Region: Curlin_rpt; pfam07012 439855006445 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 439855006446 Curlin associated repeat; Region: Curlin_rpt; pfam07012 439855006447 Curlin associated repeat; Region: Curlin_rpt; pfam07012 439855006448 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 439855006449 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855006450 DNA binding residues [nucleotide binding] 439855006451 dimerization interface [polypeptide binding]; other site 439855006452 curli assembly protein CsgE; Provisional; Region: PRK10386 439855006453 curli assembly protein CsgF; Provisional; Region: PRK10050 439855006454 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 439855006455 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 439855006456 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 439855006457 putative hydrolase; Validated; Region: PRK09248 439855006458 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 439855006459 active site 439855006460 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 439855006461 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 439855006462 putative ligand binding site [chemical binding]; other site 439855006463 NAD binding site [chemical binding]; other site 439855006464 dimerization interface [polypeptide binding]; other site 439855006465 catalytic site [active] 439855006466 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 439855006467 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 439855006468 hypothetical protein; Provisional; Region: PRK10536 439855006469 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 439855006470 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 439855006471 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 439855006472 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 439855006473 Imelysin; Region: Peptidase_M75; pfam09375 439855006474 FTR1 family protein; Region: TIGR00145 439855006475 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 439855006476 Na binding site [ion binding]; other site 439855006477 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 439855006478 Predicted transcriptional regulator [Transcription]; Region: COG3905 439855006479 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 439855006480 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 439855006481 Glutamate binding site [chemical binding]; other site 439855006482 NAD binding site [chemical binding]; other site 439855006483 catalytic residues [active] 439855006484 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 439855006485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855006486 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 439855006487 pyrimidine utilization protein A; Region: RutA; TIGR03612 439855006488 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 439855006489 active site 439855006490 dimer interface [polypeptide binding]; other site 439855006491 non-prolyl cis peptide bond; other site 439855006492 insertion regions; other site 439855006493 Isochorismatase family; Region: Isochorismatase; pfam00857 439855006494 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 439855006495 catalytic triad [active] 439855006496 conserved cis-peptide bond; other site 439855006497 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 439855006498 homotrimer interaction site [polypeptide binding]; other site 439855006499 putative active site [active] 439855006500 pyrimidine utilization protein D; Region: RutD; TIGR03611 439855006501 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 439855006502 putative FMN binding site [chemical binding]; other site 439855006503 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 439855006504 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 439855006505 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 439855006506 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 439855006507 hypothetical protein; Provisional; Region: PRK10174 439855006508 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 439855006509 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 439855006510 catalytic core [active] 439855006511 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 439855006512 hypothetical protein; Provisional; Region: PRK09784 439855006513 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 439855006514 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 439855006515 HSP70 interaction site [polypeptide binding]; other site 439855006516 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 439855006517 substrate binding site [polypeptide binding]; other site 439855006518 dimer interface [polypeptide binding]; other site 439855006519 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 439855006520 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 439855006521 chaperone protein TorD; Validated; Region: torD; PRK04976 439855006522 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 439855006523 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 439855006524 molybdopterin cofactor binding site [chemical binding]; other site 439855006525 substrate binding site [chemical binding]; other site 439855006526 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 439855006527 molybdopterin cofactor binding site; other site 439855006528 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 439855006529 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 439855006530 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 439855006531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855006532 active site 439855006533 phosphorylation site [posttranslational modification] 439855006534 intermolecular recognition site; other site 439855006535 dimerization interface [polypeptide binding]; other site 439855006536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855006537 DNA binding site [nucleotide binding] 439855006538 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 439855006539 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 439855006540 putative ligand binding site [chemical binding]; other site 439855006541 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 439855006542 HAMP domain; Region: HAMP; pfam00672 439855006543 dimerization interface [polypeptide binding]; other site 439855006544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855006545 dimer interface [polypeptide binding]; other site 439855006546 phosphorylation site [posttranslational modification] 439855006547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855006548 ATP binding site [chemical binding]; other site 439855006549 Mg2+ binding site [ion binding]; other site 439855006550 G-X-G motif; other site 439855006551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855006552 active site 439855006553 phosphorylation site [posttranslational modification] 439855006554 intermolecular recognition site; other site 439855006555 dimerization interface [polypeptide binding]; other site 439855006556 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 439855006557 putative binding surface; other site 439855006558 active site 439855006559 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 439855006560 4Fe-4S binding domain; Region: Fer4_5; pfam12801 439855006561 4Fe-4S binding domain; Region: Fer4_5; pfam12801 439855006562 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855006563 GnsA/GnsB family; Region: GnsAB; pfam08178 439855006564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 439855006565 DNA-binding site [nucleotide binding]; DNA binding site 439855006566 RNA-binding motif; other site 439855006567 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 439855006568 DNA-binding site [nucleotide binding]; DNA binding site 439855006569 RNA-binding motif; other site 439855006570 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 439855006571 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 439855006572 catalytic core [active] 439855006573 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 439855006574 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 439855006575 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 439855006576 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 439855006577 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 439855006578 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 439855006579 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 439855006580 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 439855006581 putative substrate-binding site; other site 439855006582 nickel binding site [ion binding]; other site 439855006583 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 439855006584 hydrogenase 1 large subunit; Provisional; Region: PRK10170 439855006585 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 439855006586 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 439855006587 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 439855006588 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 439855006589 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 439855006590 YccA-like proteins; Region: YccA_like; cd10433 439855006591 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 439855006592 sulfur transfer protein TusE; Provisional; Region: PRK11508 439855006593 Acylphosphatase; Region: Acylphosphatase; cl00551 439855006594 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 439855006595 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 439855006596 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 439855006597 putative RNA binding site [nucleotide binding]; other site 439855006598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855006599 S-adenosylmethionine binding site [chemical binding]; other site 439855006600 heat shock protein HspQ; Provisional; Region: PRK14129 439855006601 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 439855006602 hypothetical protein; Provisional; Region: PRK03641 439855006603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 439855006604 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 439855006605 active site 439855006606 dimer interfaces [polypeptide binding]; other site 439855006607 catalytic residues [active] 439855006608 DNA helicase IV; Provisional; Region: helD; PRK11054 439855006609 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 439855006610 Part of AAA domain; Region: AAA_19; pfam13245 439855006611 Family description; Region: UvrD_C_2; pfam13538 439855006612 Predicted membrane protein [Function unknown]; Region: COG3304 439855006613 Domain of unknown function (DUF307); Region: DUF307; pfam03733 439855006614 Domain of unknown function (DUF307); Region: DUF307; pfam03733 439855006615 TIGR01666 family membrane protein; Region: YCCS 439855006616 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 439855006617 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 439855006618 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 439855006619 TfoX C-terminal domain; Region: TfoX_C; pfam04994 439855006620 cell division inhibitor SulA; Region: sula; TIGR00623 439855006621 outer membrane protein A; Reviewed; Region: PRK10808 439855006622 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 439855006623 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855006624 ligand binding site [chemical binding]; other site 439855006625 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 439855006626 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 439855006627 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 439855006628 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 439855006629 active site 1 [active] 439855006630 dimer interface [polypeptide binding]; other site 439855006631 active site 2 [active] 439855006632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 439855006633 Protein of unknown function (DUF330); Region: DUF330; pfam03886 439855006634 paraquat-inducible protein B; Provisional; Region: PRK10807 439855006635 mce related protein; Region: MCE; pfam02470 439855006636 mce related protein; Region: MCE; pfam02470 439855006637 mce related protein; Region: MCE; pfam02470 439855006638 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 439855006639 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 439855006640 Paraquat-inducible protein A; Region: PqiA; pfam04403 439855006641 Paraquat-inducible protein A; Region: PqiA; pfam04403 439855006642 ABC transporter ATPase component; Reviewed; Region: PRK11147 439855006643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855006644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855006645 Walker A/P-loop; other site 439855006646 Walker A/P-loop; other site 439855006647 ATP binding site [chemical binding]; other site 439855006648 ATP binding site [chemical binding]; other site 439855006649 Q-loop/lid; other site 439855006650 Q-loop/lid; other site 439855006651 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 439855006652 ABC transporter signature motif; other site 439855006653 Walker B; other site 439855006654 D-loop; other site 439855006655 ABC transporter; Region: ABC_tran_2; pfam12848 439855006656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 439855006657 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 439855006658 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 439855006659 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 439855006660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855006661 S-adenosylmethionine binding site [chemical binding]; other site 439855006662 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 439855006663 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 439855006664 MOSC domain; Region: MOSC; pfam03473 439855006665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855006666 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 439855006667 catalytic loop [active] 439855006668 iron binding site [ion binding]; other site 439855006669 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 439855006670 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 439855006671 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 439855006672 quinone interaction residues [chemical binding]; other site 439855006673 active site 439855006674 catalytic residues [active] 439855006675 FMN binding site [chemical binding]; other site 439855006676 substrate binding site [chemical binding]; other site 439855006677 putativi pili assembly chaperone; Provisional; Region: PRK11385 439855006678 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855006679 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855006680 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855006681 Fimbrial protein; Region: Fimbrial; cl01416 439855006682 Fimbrial protein; Region: Fimbrial; cl01416 439855006683 outer membrane usher protein; Provisional; Region: PRK15193 439855006684 PapC N-terminal domain; Region: PapC_N; pfam13954 439855006685 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855006686 PapC C-terminal domain; Region: PapC_C; pfam13953 439855006687 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 439855006688 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855006689 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855006690 Fimbrial protein; Region: Fimbrial; cl01416 439855006691 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 439855006692 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 439855006693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855006694 substrate binding pocket [chemical binding]; other site 439855006695 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 439855006696 membrane-bound complex binding site; other site 439855006697 hinge residues; other site 439855006698 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 439855006699 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 439855006700 active site 439855006701 dimer interface [polypeptide binding]; other site 439855006702 non-prolyl cis peptide bond; other site 439855006703 insertion regions; other site 439855006704 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 439855006705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855006706 dimer interface [polypeptide binding]; other site 439855006707 conserved gate region; other site 439855006708 putative PBP binding loops; other site 439855006709 ABC-ATPase subunit interface; other site 439855006710 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 439855006711 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 439855006712 Walker A/P-loop; other site 439855006713 ATP binding site [chemical binding]; other site 439855006714 Q-loop/lid; other site 439855006715 ABC transporter signature motif; other site 439855006716 Walker B; other site 439855006717 D-loop; other site 439855006718 H-loop/switch region; other site 439855006719 aminopeptidase N; Provisional; Region: pepN; PRK14015 439855006720 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 439855006721 active site 439855006722 Zn binding site [ion binding]; other site 439855006723 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 439855006724 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 439855006725 active site 439855006726 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 439855006727 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 439855006728 putative dimer interface [polypeptide binding]; other site 439855006729 putative anticodon binding site; other site 439855006730 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 439855006731 homodimer interface [polypeptide binding]; other site 439855006732 motif 1; other site 439855006733 motif 2; other site 439855006734 active site 439855006735 motif 3; other site 439855006736 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 439855006737 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 439855006738 trimer interface [polypeptide binding]; other site 439855006739 eyelet of channel; other site 439855006740 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 439855006741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855006742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855006743 homodimer interface [polypeptide binding]; other site 439855006744 catalytic residue [active] 439855006745 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 439855006746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 439855006747 Peptidase M15; Region: Peptidase_M15_3; cl01194 439855006748 murein L,D-transpeptidase; Provisional; Region: PRK10594 439855006749 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 439855006750 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855006751 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 439855006752 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 439855006753 MukB N-terminal; Region: MukB; pfam04310 439855006754 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 439855006755 condesin subunit E; Provisional; Region: PRK05256 439855006756 condesin subunit F; Provisional; Region: PRK05260 439855006757 Methyltransferase domain; Region: Methyltransf_31; pfam13847 439855006758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855006759 S-adenosylmethionine binding site [chemical binding]; other site 439855006760 Uncharacterized conserved protein [Function unknown]; Region: COG1434 439855006761 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 439855006762 putative active site [active] 439855006763 hypothetical protein; Provisional; Region: PRK10593 439855006764 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 439855006765 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 439855006766 Ligand binding site; other site 439855006767 oligomer interface; other site 439855006768 hypothetical protein; Provisional; Region: PRK11827 439855006769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 439855006770 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 439855006771 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 439855006772 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 439855006773 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 439855006774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 439855006775 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 439855006776 Walker A/P-loop; other site 439855006777 ATP binding site [chemical binding]; other site 439855006778 Q-loop/lid; other site 439855006779 ABC transporter signature motif; other site 439855006780 Walker B; other site 439855006781 D-loop; other site 439855006782 H-loop/switch region; other site 439855006783 ComEC family competence protein; Provisional; Region: PRK11539 439855006784 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 439855006785 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 439855006786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 439855006787 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 439855006788 IHF dimer interface [polypeptide binding]; other site 439855006789 IHF - DNA interface [nucleotide binding]; other site 439855006790 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 439855006791 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 439855006792 RNA binding site [nucleotide binding]; other site 439855006793 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 439855006794 RNA binding site [nucleotide binding]; other site 439855006795 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 439855006796 RNA binding site [nucleotide binding]; other site 439855006797 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 439855006798 RNA binding site [nucleotide binding]; other site 439855006799 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 439855006800 RNA binding site [nucleotide binding]; other site 439855006801 cytidylate kinase; Provisional; Region: cmk; PRK00023 439855006802 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 439855006803 CMP-binding site; other site 439855006804 The sites determining sugar specificity; other site 439855006805 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 439855006806 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 439855006807 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 439855006808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855006809 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 439855006810 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 439855006811 hinge; other site 439855006812 active site 439855006813 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 439855006814 homodimer interface [polypeptide binding]; other site 439855006815 substrate-cofactor binding pocket; other site 439855006816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855006817 catalytic residue [active] 439855006818 Predicted membrane protein [Function unknown]; Region: COG2323 439855006819 uncharacterized domain; Region: TIGR00702 439855006820 YcaO-like family; Region: YcaO; pfam02624 439855006821 formate transporter; Provisional; Region: PRK10805 439855006822 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 439855006823 Pyruvate formate lyase 1; Region: PFL1; cd01678 439855006824 coenzyme A binding site [chemical binding]; other site 439855006825 active site 439855006826 catalytic residues [active] 439855006827 glycine loop; other site 439855006828 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 439855006829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855006830 FeS/SAM binding site; other site 439855006831 Amino acid permease; Region: AA_permease_2; pfam13520 439855006832 putative MFS family transporter protein; Provisional; Region: PRK03633 439855006833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855006834 putative substrate translocation pore; other site 439855006835 Isochorismatase family; Region: Isochorismatase; pfam00857 439855006836 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 439855006837 catalytic triad [active] 439855006838 dimer interface [polypeptide binding]; other site 439855006839 conserved cis-peptide bond; other site 439855006840 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 439855006841 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 439855006842 4Fe-4S binding domain; Region: Fer4; cl02805 439855006843 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 439855006844 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 439855006845 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 439855006846 putative [Fe4-S4] binding site [ion binding]; other site 439855006847 putative molybdopterin cofactor binding site [chemical binding]; other site 439855006848 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 439855006849 putative molybdopterin cofactor binding site; other site 439855006850 seryl-tRNA synthetase; Provisional; Region: PRK05431 439855006851 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 439855006852 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 439855006853 dimer interface [polypeptide binding]; other site 439855006854 active site 439855006855 motif 1; other site 439855006856 motif 2; other site 439855006857 motif 3; other site 439855006858 recombination factor protein RarA; Reviewed; Region: PRK13342 439855006859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855006860 Walker A motif; other site 439855006861 ATP binding site [chemical binding]; other site 439855006862 Walker B motif; other site 439855006863 arginine finger; other site 439855006864 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 439855006865 periplasmic chaperone LolA; Region: lolA; TIGR00547 439855006866 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 439855006867 DNA translocase FtsK; Provisional; Region: PRK10263 439855006868 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 439855006869 DNA translocase FtsK; Provisional; Region: PRK10263 439855006870 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 439855006871 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 439855006872 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 439855006873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855006874 putative DNA binding site [nucleotide binding]; other site 439855006875 putative Zn2+ binding site [ion binding]; other site 439855006876 AsnC family; Region: AsnC_trans_reg; pfam01037 439855006877 thioredoxin reductase; Provisional; Region: PRK10262 439855006878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855006879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855006880 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 439855006881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 439855006882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855006883 Walker A/P-loop; other site 439855006884 ATP binding site [chemical binding]; other site 439855006885 Q-loop/lid; other site 439855006886 ABC transporter signature motif; other site 439855006887 Walker B; other site 439855006888 D-loop; other site 439855006889 H-loop/switch region; other site 439855006890 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 439855006891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 439855006892 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 439855006893 Walker A/P-loop; other site 439855006894 ATP binding site [chemical binding]; other site 439855006895 Q-loop/lid; other site 439855006896 ABC transporter signature motif; other site 439855006897 Walker B; other site 439855006898 D-loop; other site 439855006899 H-loop/switch region; other site 439855006900 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 439855006901 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 439855006902 rRNA binding site [nucleotide binding]; other site 439855006903 predicted 30S ribosome binding site; other site 439855006904 Methyltransferase domain; Region: Methyltransf_27; pfam13708 439855006905 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 439855006906 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 439855006907 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 439855006908 Protein of unknown function (DUF987); Region: DUF987; pfam06174 439855006909 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 439855006910 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 439855006911 MPN+ (JAMM) motif; other site 439855006912 Zinc-binding site [ion binding]; other site 439855006913 Antirestriction protein; Region: Antirestrict; pfam03230 439855006914 Domain of unknown function (DUF932); Region: DUF932; pfam06067 439855006915 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 439855006916 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 439855006917 hypothetical protein; Provisional; Region: PRK09945 439855006918 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 439855006919 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 439855006920 Autotransporter beta-domain; Region: Autotransporter; smart00869 439855006921 Predicted GTPase [General function prediction only]; Region: COG3596 439855006922 YfjP GTPase; Region: YfjP; cd11383 439855006923 G1 box; other site 439855006924 GTP/Mg2+ binding site [chemical binding]; other site 439855006925 Switch I region; other site 439855006926 G2 box; other site 439855006927 Switch II region; other site 439855006928 G3 box; other site 439855006929 G4 box; other site 439855006930 G5 box; other site 439855006931 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 439855006932 HsdM N-terminal domain; Region: HsdM_N; pfam12161 439855006933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855006934 S-adenosylmethionine binding site [chemical binding]; other site 439855006935 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855006936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 439855006937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 439855006938 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 439855006939 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 439855006940 active site 439855006941 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 439855006942 Transposase domain (DUF772); Region: DUF772; pfam05598 439855006943 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 439855006944 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 439855006945 putative transposase OrfB; Reviewed; Region: PHA02517 439855006946 HTH-like domain; Region: HTH_21; pfam13276 439855006947 Integrase core domain; Region: rve; pfam00665 439855006948 Integrase core domain; Region: rve_3; pfam13683 439855006949 Transposase; Region: HTH_Tnp_1; cl17663 439855006950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855006951 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 439855006952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855006953 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 439855006954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 439855006955 active site 439855006956 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 439855006957 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 439855006958 putative ADP-binding pocket [chemical binding]; other site 439855006959 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 439855006960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 439855006961 active site 439855006962 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 439855006963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 439855006964 UDP-galactopyranose mutase; Region: GLF; pfam03275 439855006965 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 439855006966 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 439855006967 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 439855006968 Ligand binding site; other site 439855006969 metal-binding site 439855006970 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 439855006971 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 439855006972 Walker A/P-loop; other site 439855006973 ATP binding site [chemical binding]; other site 439855006974 Q-loop/lid; other site 439855006975 ABC transporter signature motif; other site 439855006976 Walker B; other site 439855006977 D-loop; other site 439855006978 H-loop/switch region; other site 439855006979 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 439855006980 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 439855006981 Transposase; Region: HTH_Tnp_1; cl17663 439855006982 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 439855006983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 439855006984 Transposase; Region: DDE_Tnp_ISL3; pfam01610 439855006985 Helix-turn-helix domain; Region: HTH_38; pfam13936 439855006986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 439855006987 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 439855006988 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 439855006989 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 439855006990 integrase; Provisional; Region: PRK09692 439855006991 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 439855006992 active site 439855006993 Int/Topo IB signature motif; other site 439855006994 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 439855006995 Clp amino terminal domain; Region: Clp_N; pfam02861 439855006996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855006997 Walker A motif; other site 439855006998 ATP binding site [chemical binding]; other site 439855006999 Walker B motif; other site 439855007000 arginine finger; other site 439855007001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855007002 Walker A motif; other site 439855007003 ATP binding site [chemical binding]; other site 439855007004 Walker B motif; other site 439855007005 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 439855007006 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 439855007007 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 439855007008 DNA-binding site [nucleotide binding]; DNA binding site 439855007009 RNA-binding motif; other site 439855007010 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 439855007011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 439855007012 Walker A/P-loop; other site 439855007013 ATP binding site [chemical binding]; other site 439855007014 Q-loop/lid; other site 439855007015 ABC transporter signature motif; other site 439855007016 Walker B; other site 439855007017 D-loop; other site 439855007018 H-loop/switch region; other site 439855007019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 439855007020 FtsX-like permease family; Region: FtsX; pfam02687 439855007021 macrolide transporter subunit MacA; Provisional; Region: PRK11578 439855007022 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855007023 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855007024 Protein of unknown function (DUF535); Region: DUF535; pfam04393 439855007025 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 439855007026 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 439855007027 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 439855007028 putative active site [active] 439855007029 putative metal-binding site [ion binding]; other site 439855007030 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 439855007031 amphipathic channel; other site 439855007032 Asn-Pro-Ala signature motifs; other site 439855007033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 439855007034 Transposase; Region: DEDD_Tnp_IS110; pfam01548 439855007035 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 439855007036 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 439855007037 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 439855007038 FMN binding site [chemical binding]; other site 439855007039 active site 439855007040 catalytic residues [active] 439855007041 substrate binding site [chemical binding]; other site 439855007042 hypothetical protein; Provisional; Region: PRK01821 439855007043 hypothetical protein; Provisional; Region: PRK10711 439855007044 cytidine deaminase; Provisional; Region: PRK09027 439855007045 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 439855007046 active site 439855007047 catalytic motif [active] 439855007048 Zn binding site [ion binding]; other site 439855007049 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 439855007050 active site 439855007051 catalytic motif [active] 439855007052 Zn binding site [ion binding]; other site 439855007053 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 439855007054 putative active site [active] 439855007055 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 439855007056 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 439855007057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 439855007058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855007059 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 439855007060 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 439855007061 homodimer interface [polypeptide binding]; other site 439855007062 active site 439855007063 FMN binding site [chemical binding]; other site 439855007064 substrate binding site [chemical binding]; other site 439855007065 4Fe-4S binding domain; Region: Fer4; pfam00037 439855007066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855007067 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855007068 TM-ABC transporter signature motif; other site 439855007069 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855007070 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 439855007071 Walker A/P-loop; other site 439855007072 ATP binding site [chemical binding]; other site 439855007073 Q-loop/lid; other site 439855007074 ABC transporter signature motif; other site 439855007075 Walker B; other site 439855007076 D-loop; other site 439855007077 H-loop/switch region; other site 439855007078 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855007079 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 439855007080 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 439855007081 ligand binding site [chemical binding]; other site 439855007082 calcium binding site [ion binding]; other site 439855007083 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 439855007084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855007085 DNA binding site [nucleotide binding] 439855007086 domain linker motif; other site 439855007087 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 439855007088 dimerization interface (closed form) [polypeptide binding]; other site 439855007089 ligand binding site [chemical binding]; other site 439855007090 Predicted membrane protein [Function unknown]; Region: COG2311 439855007091 hypothetical protein; Provisional; Region: PRK10835 439855007092 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 439855007093 homodecamer interface [polypeptide binding]; other site 439855007094 GTP cyclohydrolase I; Provisional; Region: PLN03044 439855007095 active site 439855007096 putative catalytic site residues [active] 439855007097 zinc binding site [ion binding]; other site 439855007098 GTP-CH-I/GFRP interaction surface; other site 439855007099 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 439855007100 S-formylglutathione hydrolase; Region: PLN02442 439855007101 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 439855007102 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855007103 N-terminal plug; other site 439855007104 ligand-binding site [chemical binding]; other site 439855007105 lysine transporter; Provisional; Region: PRK10836 439855007106 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 439855007107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855007108 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 439855007109 putative dimerization interface [polypeptide binding]; other site 439855007110 conserved hypothetical integral membrane protein; Region: TIGR00698 439855007111 endonuclease IV; Provisional; Region: PRK01060 439855007112 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 439855007113 AP (apurinic/apyrimidinic) site pocket; other site 439855007114 DNA interaction; other site 439855007115 Metal-binding active site; metal-binding site 439855007116 putative kinase; Provisional; Region: PRK09954 439855007117 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 439855007118 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 439855007119 substrate binding site [chemical binding]; other site 439855007120 ATP binding site [chemical binding]; other site 439855007121 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 439855007122 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 439855007123 Nucleoside recognition; Region: Gate; pfam07670 439855007124 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 439855007125 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 439855007126 active site 439855007127 tetramer interface [polypeptide binding]; other site 439855007128 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 439855007129 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 439855007130 ligand binding site [chemical binding]; other site 439855007131 flexible hinge region; other site 439855007132 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 439855007133 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 439855007134 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 439855007135 Nucleoside recognition; Region: Gate; pfam07670 439855007136 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 439855007137 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 439855007138 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 439855007139 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855007140 substrate binding site [chemical binding]; other site 439855007141 ATP binding site [chemical binding]; other site 439855007142 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 439855007143 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 439855007144 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 439855007145 active site 439855007146 P-loop; other site 439855007147 phosphorylation site [posttranslational modification] 439855007148 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 439855007149 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 439855007150 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 439855007151 putative substrate binding site [chemical binding]; other site 439855007152 putative ATP binding site [chemical binding]; other site 439855007153 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 439855007154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855007155 active site 439855007156 phosphorylation site [posttranslational modification] 439855007157 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855007158 dimerization domain swap beta strand [polypeptide binding]; other site 439855007159 regulatory protein interface [polypeptide binding]; other site 439855007160 active site 439855007161 regulatory phosphorylation site [posttranslational modification]; other site 439855007162 sugar efflux transporter B; Provisional; Region: PRK15011 439855007163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007164 putative substrate translocation pore; other site 439855007165 Flagellin N-methylase; Region: FliB; pfam03692 439855007166 elongation factor P; Provisional; Region: PRK04542 439855007167 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 439855007168 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 439855007169 RNA binding site [nucleotide binding]; other site 439855007170 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 439855007171 RNA binding site [nucleotide binding]; other site 439855007172 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 439855007173 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 439855007174 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 439855007175 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 439855007176 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 439855007177 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 439855007178 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 439855007179 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 439855007180 active site 439855007181 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 439855007182 NlpC/P60 family; Region: NLPC_P60; pfam00877 439855007183 phage resistance protein; Provisional; Region: PRK10551 439855007184 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 439855007185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855007186 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 439855007187 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 439855007188 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 439855007189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855007190 dimer interface [polypeptide binding]; other site 439855007191 conserved gate region; other site 439855007192 putative PBP binding loops; other site 439855007193 ABC-ATPase subunit interface; other site 439855007194 microcin C ABC transporter permease; Provisional; Region: PRK15021 439855007195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855007196 dimer interface [polypeptide binding]; other site 439855007197 conserved gate region; other site 439855007198 ABC-ATPase subunit interface; other site 439855007199 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 439855007200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855007201 Walker A/P-loop; other site 439855007202 ATP binding site [chemical binding]; other site 439855007203 Q-loop/lid; other site 439855007204 ABC transporter signature motif; other site 439855007205 Walker B; other site 439855007206 D-loop; other site 439855007207 H-loop/switch region; other site 439855007208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 439855007209 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855007210 Walker A/P-loop; other site 439855007211 ATP binding site [chemical binding]; other site 439855007212 Q-loop/lid; other site 439855007213 ABC transporter signature motif; other site 439855007214 Walker B; other site 439855007215 D-loop; other site 439855007216 H-loop/switch region; other site 439855007217 hypothetical protein; Provisional; Region: PRK11835 439855007218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007219 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 439855007220 putative substrate translocation pore; other site 439855007221 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 439855007222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855007223 RNA binding surface [nucleotide binding]; other site 439855007224 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 439855007225 active site 439855007226 uracil binding [chemical binding]; other site 439855007227 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 439855007228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855007229 ATP binding site [chemical binding]; other site 439855007230 putative Mg++ binding site [ion binding]; other site 439855007231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855007232 nucleotide binding region [chemical binding]; other site 439855007233 ATP-binding site [chemical binding]; other site 439855007234 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 439855007235 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 439855007236 5S rRNA interface [nucleotide binding]; other site 439855007237 CTC domain interface [polypeptide binding]; other site 439855007238 L16 interface [polypeptide binding]; other site 439855007239 Nucleoid-associated protein [General function prediction only]; Region: COG3081 439855007240 nucleoid-associated protein NdpA; Validated; Region: PRK00378 439855007241 hypothetical protein; Provisional; Region: PRK13689 439855007242 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 439855007243 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 439855007244 Sulfatase; Region: Sulfatase; pfam00884 439855007245 transcriptional regulator NarP; Provisional; Region: PRK10403 439855007246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007247 active site 439855007248 phosphorylation site [posttranslational modification] 439855007249 intermolecular recognition site; other site 439855007250 dimerization interface [polypeptide binding]; other site 439855007251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855007252 DNA binding residues [nucleotide binding] 439855007253 dimerization interface [polypeptide binding]; other site 439855007254 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 439855007255 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 439855007256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855007257 binding surface 439855007258 TPR motif; other site 439855007259 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 439855007260 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 439855007261 catalytic residues [active] 439855007262 central insert; other site 439855007263 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 439855007264 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 439855007265 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 439855007266 heme exporter protein CcmC; Region: ccmC; TIGR01191 439855007267 heme exporter protein CcmB; Region: ccmB; TIGR01190 439855007268 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 439855007269 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 439855007270 Walker A/P-loop; other site 439855007271 ATP binding site [chemical binding]; other site 439855007272 Q-loop/lid; other site 439855007273 ABC transporter signature motif; other site 439855007274 Walker B; other site 439855007275 D-loop; other site 439855007276 H-loop/switch region; other site 439855007277 cytochrome c-type protein NapC; Provisional; Region: PRK10617 439855007278 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 439855007279 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 439855007280 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 439855007281 4Fe-4S binding domain; Region: Fer4_5; pfam12801 439855007282 4Fe-4S binding domain; Region: Fer4; cl02805 439855007283 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 439855007284 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 439855007285 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 439855007286 [4Fe-4S] binding site [ion binding]; other site 439855007287 molybdopterin cofactor binding site; other site 439855007288 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 439855007289 molybdopterin cofactor binding site; other site 439855007290 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 439855007291 ferredoxin-type protein; Provisional; Region: PRK10194 439855007292 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 439855007293 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 439855007294 secondary substrate binding site; other site 439855007295 primary substrate binding site; other site 439855007296 inhibition loop; other site 439855007297 dimerization interface [polypeptide binding]; other site 439855007298 malate:quinone oxidoreductase; Validated; Region: PRK05257 439855007299 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 439855007300 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 439855007301 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 439855007302 Walker A/P-loop; other site 439855007303 ATP binding site [chemical binding]; other site 439855007304 Q-loop/lid; other site 439855007305 ABC transporter signature motif; other site 439855007306 Walker B; other site 439855007307 D-loop; other site 439855007308 H-loop/switch region; other site 439855007309 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 439855007310 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 439855007311 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 439855007312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855007313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855007314 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 439855007315 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 439855007316 DNA binding site [nucleotide binding] 439855007317 active site 439855007318 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 439855007319 ApbE family; Region: ApbE; pfam02424 439855007320 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 439855007321 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 439855007322 trimer interface [polypeptide binding]; other site 439855007323 eyelet of channel; other site 439855007324 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 439855007325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855007326 ATP binding site [chemical binding]; other site 439855007327 G-X-G motif; other site 439855007328 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 439855007329 putative binding surface; other site 439855007330 active site 439855007331 transcriptional regulator RcsB; Provisional; Region: PRK10840 439855007332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007333 active site 439855007334 phosphorylation site [posttranslational modification] 439855007335 intermolecular recognition site; other site 439855007336 dimerization interface [polypeptide binding]; other site 439855007337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855007338 DNA binding residues [nucleotide binding] 439855007339 dimerization interface [polypeptide binding]; other site 439855007340 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 439855007341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855007342 dimer interface [polypeptide binding]; other site 439855007343 phosphorylation site [posttranslational modification] 439855007344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855007345 ATP binding site [chemical binding]; other site 439855007346 Mg2+ binding site [ion binding]; other site 439855007347 G-X-G motif; other site 439855007348 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 439855007349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007350 active site 439855007351 phosphorylation site [posttranslational modification] 439855007352 intermolecular recognition site; other site 439855007353 dimerization interface [polypeptide binding]; other site 439855007354 sensory histidine kinase AtoS; Provisional; Region: PRK11360 439855007355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855007356 putative active site [active] 439855007357 heme pocket [chemical binding]; other site 439855007358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855007359 dimer interface [polypeptide binding]; other site 439855007360 phosphorylation site [posttranslational modification] 439855007361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855007362 ATP binding site [chemical binding]; other site 439855007363 Mg2+ binding site [ion binding]; other site 439855007364 G-X-G motif; other site 439855007365 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 439855007366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007367 active site 439855007368 phosphorylation site [posttranslational modification] 439855007369 intermolecular recognition site; other site 439855007370 dimerization interface [polypeptide binding]; other site 439855007371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855007372 Walker A motif; other site 439855007373 ATP binding site [chemical binding]; other site 439855007374 Walker B motif; other site 439855007375 arginine finger; other site 439855007376 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855007377 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 439855007378 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 439855007379 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 439855007380 putative acyltransferase; Provisional; Region: PRK05790 439855007381 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 439855007382 dimer interface [polypeptide binding]; other site 439855007383 active site 439855007384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 439855007385 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 439855007386 Predicted secreted protein [Function unknown]; Region: COG5445 439855007387 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 439855007388 Predicted secreted protein [Function unknown]; Region: COG5445 439855007389 Stage II sporulation protein; Region: SpoIID; pfam08486 439855007390 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 439855007391 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 439855007392 MG2 domain; Region: A2M_N; pfam01835 439855007393 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 439855007394 Alpha-2-macroglobulin family; Region: A2M; pfam00207 439855007395 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 439855007396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 439855007397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 439855007398 DNA gyrase subunit A; Validated; Region: PRK05560 439855007399 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 439855007400 CAP-like domain; other site 439855007401 active site 439855007402 primary dimer interface [polypeptide binding]; other site 439855007403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855007404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855007405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855007406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855007407 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855007408 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855007409 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 439855007410 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 439855007411 active site pocket [active] 439855007412 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 439855007413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007414 putative substrate translocation pore; other site 439855007415 Transcriptional regulators [Transcription]; Region: GntR; COG1802 439855007416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855007417 DNA-binding site [nucleotide binding]; DNA binding site 439855007418 FCD domain; Region: FCD; pfam07729 439855007419 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 439855007420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855007421 S-adenosylmethionine binding site [chemical binding]; other site 439855007422 adhesin; Provisional; Region: PRK09752 439855007423 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 439855007424 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855007425 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 439855007426 ATP cone domain; Region: ATP-cone; pfam03477 439855007427 Class I ribonucleotide reductase; Region: RNR_I; cd01679 439855007428 active site 439855007429 dimer interface [polypeptide binding]; other site 439855007430 catalytic residues [active] 439855007431 effector binding site; other site 439855007432 R2 peptide binding site; other site 439855007433 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 439855007434 dimer interface [polypeptide binding]; other site 439855007435 putative radical transfer pathway; other site 439855007436 diiron center [ion binding]; other site 439855007437 tyrosyl radical; other site 439855007438 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 439855007439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855007440 catalytic loop [active] 439855007441 iron binding site [ion binding]; other site 439855007442 hypothetical protein; Provisional; Region: PRK09902 439855007443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855007444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007445 putative substrate translocation pore; other site 439855007446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855007447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855007448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 439855007449 dimerization interface [polypeptide binding]; other site 439855007450 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 439855007451 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 439855007452 active site 439855007453 catalytic site [active] 439855007454 metal binding site [ion binding]; metal-binding site 439855007455 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 439855007456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007457 putative substrate translocation pore; other site 439855007458 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 439855007459 hydroxyglutarate oxidase; Provisional; Region: PRK11728 439855007460 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 439855007461 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 439855007462 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 439855007463 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 439855007464 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855007465 Cysteine-rich domain; Region: CCG; pfam02754 439855007466 Cysteine-rich domain; Region: CCG; pfam02754 439855007467 hypothetical protein; Provisional; Region: PRK09956 439855007468 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 439855007469 hypothetical protein; Provisional; Region: PRK09956 439855007470 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 439855007471 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 439855007472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007473 putative substrate translocation pore; other site 439855007474 L-rhamnonate dehydratase; Provisional; Region: PRK15440 439855007475 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 439855007476 putative active site pocket [active] 439855007477 putative metal binding site [ion binding]; other site 439855007478 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 439855007479 Transcriptional regulator [Transcription]; Region: IclR; COG1414 439855007480 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855007481 hypothetical protein; Provisional; Region: PRK03673 439855007482 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 439855007483 putative MPT binding site; other site 439855007484 Competence-damaged protein; Region: CinA; cl00666 439855007485 YfaZ precursor; Region: YfaZ; pfam07437 439855007486 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 439855007487 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 439855007488 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 439855007489 catalytic core [active] 439855007490 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 439855007491 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 439855007492 inhibitor-cofactor binding pocket; inhibition site 439855007493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855007494 catalytic residue [active] 439855007495 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 439855007496 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 439855007497 Ligand binding site; other site 439855007498 Putative Catalytic site; other site 439855007499 DXD motif; other site 439855007500 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 439855007501 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 439855007502 substrate binding site [chemical binding]; other site 439855007503 cosubstrate binding site; other site 439855007504 catalytic site [active] 439855007505 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 439855007506 active site 439855007507 hexamer interface [polypeptide binding]; other site 439855007508 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 439855007509 NAD binding site [chemical binding]; other site 439855007510 substrate binding site [chemical binding]; other site 439855007511 active site 439855007512 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 439855007513 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 439855007514 putative active site [active] 439855007515 putative catalytic site [active] 439855007516 putative Zn binding site [ion binding]; other site 439855007517 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 439855007518 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 439855007519 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 439855007520 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 439855007521 signal transduction protein PmrD; Provisional; Region: PRK15450 439855007522 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 439855007523 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 439855007524 acyl-activating enzyme (AAE) consensus motif; other site 439855007525 putative AMP binding site [chemical binding]; other site 439855007526 putative active site [active] 439855007527 putative CoA binding site [chemical binding]; other site 439855007528 O-succinylbenzoate synthase; Provisional; Region: PRK05105 439855007529 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 439855007530 active site 439855007531 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 439855007532 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 439855007533 substrate binding site [chemical binding]; other site 439855007534 oxyanion hole (OAH) forming residues; other site 439855007535 trimer interface [polypeptide binding]; other site 439855007536 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 439855007537 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 439855007538 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 439855007539 dimer interface [polypeptide binding]; other site 439855007540 tetramer interface [polypeptide binding]; other site 439855007541 PYR/PP interface [polypeptide binding]; other site 439855007542 TPP binding site [chemical binding]; other site 439855007543 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 439855007544 TPP-binding site; other site 439855007545 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 439855007546 isochorismate synthases; Region: isochor_syn; TIGR00543 439855007547 hypothetical protein; Provisional; Region: PRK10404 439855007548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855007549 Coenzyme A binding pocket [chemical binding]; other site 439855007550 ribonuclease BN; Region: true_RNase_BN; TIGR02649 439855007551 von Willebrand factor; Region: vWF_A; pfam12450 439855007552 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 439855007553 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 439855007554 metal ion-dependent adhesion site (MIDAS); other site 439855007555 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 439855007556 M28 Zn-Peptidases; Region: M28_like_1; cd05640 439855007557 Peptidase family M28; Region: Peptidase_M28; pfam04389 439855007558 metal binding site [ion binding]; metal-binding site 439855007559 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 439855007560 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 439855007561 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855007562 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 439855007563 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855007564 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 439855007565 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 439855007566 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855007567 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 439855007568 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 439855007569 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 439855007570 4Fe-4S binding domain; Region: Fer4; pfam00037 439855007571 4Fe-4S binding domain; Region: Fer4; pfam00037 439855007572 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 439855007573 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 439855007574 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855007575 catalytic loop [active] 439855007576 iron binding site [ion binding]; other site 439855007577 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 439855007578 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 439855007579 [4Fe-4S] binding site [ion binding]; other site 439855007580 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 439855007581 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 439855007582 SLBB domain; Region: SLBB; pfam10531 439855007583 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 439855007584 NADH dehydrogenase subunit E; Validated; Region: PRK07539 439855007585 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 439855007586 putative dimer interface [polypeptide binding]; other site 439855007587 [2Fe-2S] cluster binding site [ion binding]; other site 439855007588 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 439855007589 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 439855007590 NADH dehydrogenase subunit D; Validated; Region: PRK06075 439855007591 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 439855007592 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 439855007593 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 439855007594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855007595 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 439855007596 putative dimerization interface [polypeptide binding]; other site 439855007597 aminotransferase AlaT; Validated; Region: PRK09265 439855007598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855007599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855007600 homodimer interface [polypeptide binding]; other site 439855007601 catalytic residue [active] 439855007602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855007603 Zn2+ binding site [ion binding]; other site 439855007604 Mg2+ binding site [ion binding]; other site 439855007605 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 439855007606 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 439855007607 TrkA-C domain; Region: TrkA_C; pfam02080 439855007608 TrkA-C domain; Region: TrkA_C; pfam02080 439855007609 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 439855007610 putative phosphatase; Provisional; Region: PRK11587 439855007611 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 439855007612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855007613 motif II; other site 439855007614 hypothetical protein; Validated; Region: PRK05445 439855007615 hypothetical protein; Provisional; Region: PRK01816 439855007616 propionate/acetate kinase; Provisional; Region: PRK12379 439855007617 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 439855007618 phosphate acetyltransferase; Reviewed; Region: PRK05632 439855007619 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 439855007620 DRTGG domain; Region: DRTGG; pfam07085 439855007621 phosphate acetyltransferase; Region: pta; TIGR00651 439855007622 hypothetical protein; Provisional; Region: PRK11588 439855007623 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 439855007624 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 439855007625 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 439855007626 nudix motif; other site 439855007627 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 439855007628 active site 439855007629 metal binding site [ion binding]; metal-binding site 439855007630 homotetramer interface [polypeptide binding]; other site 439855007631 glutathione S-transferase; Provisional; Region: PRK15113 439855007632 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 439855007633 C-terminal domain interface [polypeptide binding]; other site 439855007634 GSH binding site (G-site) [chemical binding]; other site 439855007635 dimer interface [polypeptide binding]; other site 439855007636 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 439855007637 N-terminal domain interface [polypeptide binding]; other site 439855007638 putative dimer interface [polypeptide binding]; other site 439855007639 putative substrate binding pocket (H-site) [chemical binding]; other site 439855007640 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 439855007641 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 439855007642 C-terminal domain interface [polypeptide binding]; other site 439855007643 GSH binding site (G-site) [chemical binding]; other site 439855007644 dimer interface [polypeptide binding]; other site 439855007645 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 439855007646 N-terminal domain interface [polypeptide binding]; other site 439855007647 putative dimer interface [polypeptide binding]; other site 439855007648 active site 439855007649 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 439855007650 homooctamer interface [polypeptide binding]; other site 439855007651 active site 439855007652 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 439855007653 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 439855007654 putative NAD(P) binding site [chemical binding]; other site 439855007655 putative active site [active] 439855007656 putative transposase; Provisional; Region: PRK09857 439855007657 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 439855007658 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 439855007659 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 439855007660 Walker A/P-loop; other site 439855007661 ATP binding site [chemical binding]; other site 439855007662 Q-loop/lid; other site 439855007663 ABC transporter signature motif; other site 439855007664 Walker B; other site 439855007665 D-loop; other site 439855007666 H-loop/switch region; other site 439855007667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855007668 dimer interface [polypeptide binding]; other site 439855007669 conserved gate region; other site 439855007670 putative PBP binding loops; other site 439855007671 ABC-ATPase subunit interface; other site 439855007672 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855007673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855007674 dimer interface [polypeptide binding]; other site 439855007675 conserved gate region; other site 439855007676 putative PBP binding loops; other site 439855007677 ABC-ATPase subunit interface; other site 439855007678 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 439855007679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855007680 substrate binding pocket [chemical binding]; other site 439855007681 membrane-bound complex binding site; other site 439855007682 hinge residues; other site 439855007683 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 439855007684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855007685 substrate binding pocket [chemical binding]; other site 439855007686 membrane-bound complex binding site; other site 439855007687 hinge residues; other site 439855007688 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 439855007689 Flavoprotein; Region: Flavoprotein; pfam02441 439855007690 amidophosphoribosyltransferase; Provisional; Region: PRK09246 439855007691 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 439855007692 active site 439855007693 tetramer interface [polypeptide binding]; other site 439855007694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855007695 active site 439855007696 colicin V production protein; Provisional; Region: PRK10845 439855007697 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 439855007698 cell division protein DedD; Provisional; Region: PRK11633 439855007699 Sporulation related domain; Region: SPOR; pfam05036 439855007700 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 439855007701 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 439855007702 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 439855007703 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 439855007704 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 439855007705 hypothetical protein; Provisional; Region: PRK10847 439855007706 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 439855007707 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 439855007708 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 439855007709 dimerization interface 3.5A [polypeptide binding]; other site 439855007710 active site 439855007711 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 439855007712 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 439855007713 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 439855007714 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 439855007715 ligand binding site [chemical binding]; other site 439855007716 NAD binding site [chemical binding]; other site 439855007717 catalytic site [active] 439855007718 homodimer interface [polypeptide binding]; other site 439855007719 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 439855007720 putative transporter; Provisional; Region: PRK12382 439855007721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007722 putative substrate translocation pore; other site 439855007723 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 439855007724 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 439855007725 dimer interface [polypeptide binding]; other site 439855007726 active site 439855007727 Uncharacterized conserved protein [Function unknown]; Region: COG4121 439855007728 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 439855007729 YfcL protein; Region: YfcL; pfam08891 439855007730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 439855007731 hypothetical protein; Provisional; Region: PRK10621 439855007732 Predicted permeases [General function prediction only]; Region: COG0730 439855007733 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 439855007734 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 439855007735 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 439855007736 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 439855007737 Tetramer interface [polypeptide binding]; other site 439855007738 active site 439855007739 FMN-binding site [chemical binding]; other site 439855007740 HemK family putative methylases; Region: hemK_fam; TIGR00536 439855007741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855007742 S-adenosylmethionine binding site [chemical binding]; other site 439855007743 hypothetical protein; Provisional; Region: PRK04946 439855007744 Smr domain; Region: Smr; pfam01713 439855007745 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 439855007746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855007747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855007748 Walker A/P-loop; other site 439855007749 Walker A/P-loop; other site 439855007750 ATP binding site [chemical binding]; other site 439855007751 ATP binding site [chemical binding]; other site 439855007752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855007753 Q-loop/lid; other site 439855007754 ABC transporter signature motif; other site 439855007755 Walker B; other site 439855007756 D-loop; other site 439855007757 H-loop/switch region; other site 439855007758 TIGR02646 family protein; Region: TIGR02646 439855007759 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 439855007760 Fimbrial protein; Region: Fimbrial; cl01416 439855007761 Fimbrial protein; Region: Fimbrial; cl01416 439855007762 Fimbrial protein; Region: Fimbrial; cl01416 439855007763 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855007764 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855007765 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 439855007766 PapC N-terminal domain; Region: PapC_N; pfam13954 439855007767 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855007768 PapC C-terminal domain; Region: PapC_C; pfam13953 439855007769 Fimbrial protein; Region: Fimbrial; cl01416 439855007770 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 439855007771 catalytic core [active] 439855007772 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 439855007773 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 439855007774 substrate binding site [chemical binding]; other site 439855007775 oxyanion hole (OAH) forming residues; other site 439855007776 trimer interface [polypeptide binding]; other site 439855007777 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 439855007778 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 439855007779 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 439855007780 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 439855007781 dimer interface [polypeptide binding]; other site 439855007782 active site 439855007783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 439855007784 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 439855007785 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 439855007786 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 439855007787 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 439855007788 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 439855007789 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 439855007790 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 439855007791 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 439855007792 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855007793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 439855007794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855007795 DNA binding residues [nucleotide binding] 439855007796 dimerization interface [polypeptide binding]; other site 439855007797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 439855007798 active site 439855007799 DNA binding site [nucleotide binding] 439855007800 Int/Topo IB signature motif; other site 439855007801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 439855007802 active site 439855007803 DNA binding site [nucleotide binding] 439855007804 Int/Topo IB signature motif; other site 439855007805 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 439855007806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855007807 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 439855007808 dimerization interface [polypeptide binding]; other site 439855007809 substrate binding pocket [chemical binding]; other site 439855007810 permease DsdX; Provisional; Region: PRK09921 439855007811 gluconate transporter; Region: gntP; TIGR00791 439855007812 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 439855007813 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 439855007814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855007815 catalytic residue [active] 439855007816 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 439855007817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007818 putative substrate translocation pore; other site 439855007819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007820 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 439855007821 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855007822 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855007823 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 439855007824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007825 active site 439855007826 phosphorylation site [posttranslational modification] 439855007827 intermolecular recognition site; other site 439855007828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855007829 DNA binding residues [nucleotide binding] 439855007830 dimerization interface [polypeptide binding]; other site 439855007831 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 439855007832 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855007833 substrate binding pocket [chemical binding]; other site 439855007834 membrane-bound complex binding site; other site 439855007835 hinge residues; other site 439855007836 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855007837 substrate binding pocket [chemical binding]; other site 439855007838 membrane-bound complex binding site; other site 439855007839 hinge residues; other site 439855007840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855007841 dimer interface [polypeptide binding]; other site 439855007842 phosphorylation site [posttranslational modification] 439855007843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855007844 ATP binding site [chemical binding]; other site 439855007845 Mg2+ binding site [ion binding]; other site 439855007846 G-X-G motif; other site 439855007847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007848 active site 439855007849 phosphorylation site [posttranslational modification] 439855007850 intermolecular recognition site; other site 439855007851 dimerization interface [polypeptide binding]; other site 439855007852 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 439855007853 putative binding surface; other site 439855007854 active site 439855007855 putative CoA-transferase; Provisional; Region: PRK11430 439855007856 CoA-transferase family III; Region: CoA_transf_3; pfam02515 439855007857 putative transporter YfdV; Provisional; Region: PRK09903 439855007858 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 439855007859 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 439855007860 PYR/PP interface [polypeptide binding]; other site 439855007861 dimer interface [polypeptide binding]; other site 439855007862 TPP binding site [chemical binding]; other site 439855007863 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855007864 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 439855007865 TPP-binding site; other site 439855007866 dimer interface [polypeptide binding]; other site 439855007867 formyl-coenzyme A transferase; Provisional; Region: PRK05398 439855007868 CoA-transferase family III; Region: CoA_transf_3; pfam02515 439855007869 hypothetical protein; Provisional; Region: PRK10316 439855007870 YfdX protein; Region: YfdX; pfam10938 439855007871 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 439855007872 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 439855007873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 439855007874 putative acyl-acceptor binding pocket; other site 439855007875 aminotransferase; Validated; Region: PRK08175 439855007876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855007877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855007878 homodimer interface [polypeptide binding]; other site 439855007879 catalytic residue [active] 439855007880 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 439855007881 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 439855007882 GAF domain; Region: GAF; pfam01590 439855007883 Histidine kinase; Region: His_kinase; pfam06580 439855007884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855007885 ATP binding site [chemical binding]; other site 439855007886 Mg2+ binding site [ion binding]; other site 439855007887 G-X-G motif; other site 439855007888 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 439855007889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855007890 active site 439855007891 phosphorylation site [posttranslational modification] 439855007892 intermolecular recognition site; other site 439855007893 dimerization interface [polypeptide binding]; other site 439855007894 LytTr DNA-binding domain; Region: LytTR; pfam04397 439855007895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855007896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855007897 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855007898 dimerization domain swap beta strand [polypeptide binding]; other site 439855007899 regulatory protein interface [polypeptide binding]; other site 439855007900 active site 439855007901 regulatory phosphorylation site [posttranslational modification]; other site 439855007902 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 439855007903 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 439855007904 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855007905 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 439855007906 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855007907 active site 439855007908 phosphorylation site [posttranslational modification] 439855007909 exoaminopeptidase; Provisional; Region: PRK09961 439855007910 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 439855007911 oligomer interface [polypeptide binding]; other site 439855007912 active site 439855007913 metal binding site [ion binding]; metal-binding site 439855007914 aminopeptidase; Provisional; Region: PRK09795 439855007915 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 439855007916 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 439855007917 active site 439855007918 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 439855007919 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 439855007920 active site 439855007921 P-loop; other site 439855007922 phosphorylation site [posttranslational modification] 439855007923 glucokinase; Provisional; Region: glk; PRK00292 439855007924 glucokinase, proteobacterial type; Region: glk; TIGR00749 439855007925 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 439855007926 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 439855007927 Cl- selectivity filter; other site 439855007928 Cl- binding residues [ion binding]; other site 439855007929 pore gating glutamate residue; other site 439855007930 dimer interface [polypeptide binding]; other site 439855007931 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 439855007932 manganese transport protein MntH; Reviewed; Region: PRK00701 439855007933 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 439855007934 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 439855007935 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 439855007936 Nucleoside recognition; Region: Gate; pfam07670 439855007937 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 439855007938 MASE1; Region: MASE1; pfam05231 439855007939 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855007940 diguanylate cyclase; Region: GGDEF; smart00267 439855007941 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855007942 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 439855007943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855007944 salt bridge; other site 439855007945 non-specific DNA binding site [nucleotide binding]; other site 439855007946 sequence-specific DNA binding site [nucleotide binding]; other site 439855007947 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 439855007948 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 439855007949 active site 439855007950 HIGH motif; other site 439855007951 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 439855007952 active site 439855007953 KMSKS motif; other site 439855007954 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 439855007955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855007956 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 439855007957 putative dimerization interface [polypeptide binding]; other site 439855007958 putative substrate binding pocket [chemical binding]; other site 439855007959 XapX domain; Region: XapX; TIGR03510 439855007960 nucleoside transporter; Region: 2A0110; TIGR00889 439855007961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855007962 putative substrate translocation pore; other site 439855007963 purine nucleoside phosphorylase; Provisional; Region: PRK08202 439855007964 hypothetical protein; Provisional; Region: PRK11528 439855007965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855007966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855007967 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 439855007968 putative dimerization interface [polypeptide binding]; other site 439855007969 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 439855007970 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 439855007971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 439855007972 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 439855007973 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 439855007974 nucleotide binding pocket [chemical binding]; other site 439855007975 K-X-D-G motif; other site 439855007976 catalytic site [active] 439855007977 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 439855007978 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 439855007979 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 439855007980 Dimer interface [polypeptide binding]; other site 439855007981 BRCT sequence motif; other site 439855007982 cell division protein ZipA; Provisional; Region: PRK03427 439855007983 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 439855007984 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 439855007985 FtsZ protein binding site [polypeptide binding]; other site 439855007986 putative sulfate transport protein CysZ; Validated; Region: PRK04949 439855007987 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 439855007988 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 439855007989 dimer interface [polypeptide binding]; other site 439855007990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855007991 catalytic residue [active] 439855007992 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855007993 dimerization domain swap beta strand [polypeptide binding]; other site 439855007994 regulatory protein interface [polypeptide binding]; other site 439855007995 active site 439855007996 regulatory phosphorylation site [posttranslational modification]; other site 439855007997 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 439855007998 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 439855007999 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855008000 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 439855008001 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 439855008002 HPr interaction site; other site 439855008003 glycerol kinase (GK) interaction site [polypeptide binding]; other site 439855008004 active site 439855008005 phosphorylation site [posttranslational modification] 439855008006 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 439855008007 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 439855008008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855008009 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 439855008010 dimer interface [polypeptide binding]; other site 439855008011 pyridoxamine kinase; Validated; Region: PRK05756 439855008012 pyridoxal binding site [chemical binding]; other site 439855008013 ATP binding site [chemical binding]; other site 439855008014 hypothetical protein; Provisional; Region: PRK10318 439855008015 cysteine synthase B; Region: cysM; TIGR01138 439855008016 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 439855008017 dimer interface [polypeptide binding]; other site 439855008018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855008019 catalytic residue [active] 439855008020 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 439855008021 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 439855008022 Walker A/P-loop; other site 439855008023 ATP binding site [chemical binding]; other site 439855008024 Q-loop/lid; other site 439855008025 ABC transporter signature motif; other site 439855008026 Walker B; other site 439855008027 D-loop; other site 439855008028 H-loop/switch region; other site 439855008029 TOBE-like domain; Region: TOBE_3; pfam12857 439855008030 sulfate transport protein; Provisional; Region: cysT; CHL00187 439855008031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855008032 dimer interface [polypeptide binding]; other site 439855008033 conserved gate region; other site 439855008034 putative PBP binding loops; other site 439855008035 ABC-ATPase subunit interface; other site 439855008036 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 439855008037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855008038 dimer interface [polypeptide binding]; other site 439855008039 conserved gate region; other site 439855008040 putative PBP binding loops; other site 439855008041 ABC-ATPase subunit interface; other site 439855008042 thiosulfate transporter subunit; Provisional; Region: PRK10852 439855008043 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 439855008044 short chain dehydrogenase; Provisional; Region: PRK08226 439855008045 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 439855008046 NAD binding site [chemical binding]; other site 439855008047 homotetramer interface [polypeptide binding]; other site 439855008048 homodimer interface [polypeptide binding]; other site 439855008049 active site 439855008050 transcriptional regulator MurR; Provisional; Region: PRK15482 439855008051 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 439855008052 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 439855008053 putative active site [active] 439855008054 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 439855008055 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 439855008056 putative active site [active] 439855008057 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 439855008058 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855008059 active site turn [active] 439855008060 phosphorylation site [posttranslational modification] 439855008061 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 439855008062 putative periplasmic esterase; Provisional; Region: PRK03642 439855008063 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 439855008064 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 439855008065 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 439855008066 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 439855008067 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 439855008068 putative acetyltransferase; Provisional; Region: PRK03624 439855008069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855008070 Coenzyme A binding pocket [chemical binding]; other site 439855008071 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 439855008072 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 439855008073 active site 439855008074 metal binding site [ion binding]; metal-binding site 439855008075 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 439855008076 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 439855008077 transcriptional regulator EutR; Provisional; Region: PRK10130 439855008078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855008079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855008080 carboxysome structural protein EutK; Provisional; Region: PRK15466 439855008081 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 439855008082 Hexamer interface [polypeptide binding]; other site 439855008083 Hexagonal pore residue; other site 439855008084 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 439855008085 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 439855008086 putative hexamer interface [polypeptide binding]; other site 439855008087 putative hexagonal pore; other site 439855008088 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 439855008089 putative hexamer interface [polypeptide binding]; other site 439855008090 putative hexagonal pore; other site 439855008091 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 439855008092 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 439855008093 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 439855008094 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 439855008095 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 439855008096 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 439855008097 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 439855008098 active site 439855008099 metal binding site [ion binding]; metal-binding site 439855008100 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 439855008101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855008102 nucleotide binding site [chemical binding]; other site 439855008103 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 439855008104 putative catalytic cysteine [active] 439855008105 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 439855008106 Hexamer/Pentamer interface [polypeptide binding]; other site 439855008107 central pore; other site 439855008108 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 439855008109 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 439855008110 Hexamer interface [polypeptide binding]; other site 439855008111 Putative hexagonal pore residue; other site 439855008112 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 439855008113 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 439855008114 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 439855008115 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 439855008116 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 439855008117 G1 box; other site 439855008118 GTP/Mg2+ binding site [chemical binding]; other site 439855008119 G2 box; other site 439855008120 Switch I region; other site 439855008121 G3 box; other site 439855008122 Switch II region; other site 439855008123 G4 box; other site 439855008124 G5 box; other site 439855008125 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 439855008126 putative hexamer interface [polypeptide binding]; other site 439855008127 putative hexagonal pore; other site 439855008128 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 439855008129 Malic enzyme, N-terminal domain; Region: malic; pfam00390 439855008130 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 439855008131 putative NAD(P) binding site [chemical binding]; other site 439855008132 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 439855008133 transaldolase-like protein; Provisional; Region: PTZ00411 439855008134 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 439855008135 active site 439855008136 dimer interface [polypeptide binding]; other site 439855008137 catalytic residue [active] 439855008138 transketolase; Reviewed; Region: PRK12753 439855008139 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 439855008140 TPP-binding site [chemical binding]; other site 439855008141 dimer interface [polypeptide binding]; other site 439855008142 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 439855008143 PYR/PP interface [polypeptide binding]; other site 439855008144 dimer interface [polypeptide binding]; other site 439855008145 TPP binding site [chemical binding]; other site 439855008146 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 439855008147 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 439855008148 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 439855008149 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 439855008150 dimer interface [polypeptide binding]; other site 439855008151 ADP-ribose binding site [chemical binding]; other site 439855008152 active site 439855008153 nudix motif; other site 439855008154 metal binding site [ion binding]; metal-binding site 439855008155 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 439855008156 4Fe-4S binding domain; Region: Fer4; pfam00037 439855008157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 439855008158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855008159 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 439855008160 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 439855008161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855008162 dimerization interface [polypeptide binding]; other site 439855008163 Histidine kinase; Region: HisKA_3; pfam07730 439855008164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855008165 ATP binding site [chemical binding]; other site 439855008166 Mg2+ binding site [ion binding]; other site 439855008167 G-X-G motif; other site 439855008168 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 439855008169 Protein export membrane protein; Region: SecD_SecF; cl14618 439855008170 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 439855008171 ArsC family; Region: ArsC; pfam03960 439855008172 putative catalytic residues [active] 439855008173 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 439855008174 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 439855008175 metal binding site [ion binding]; metal-binding site 439855008176 dimer interface [polypeptide binding]; other site 439855008177 hypothetical protein; Provisional; Region: PRK13664 439855008178 putative hydrolase; Provisional; Region: PRK11460 439855008179 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 439855008180 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 439855008181 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 439855008182 Helicase; Region: Helicase_RecD; pfam05127 439855008183 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 439855008184 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 439855008185 Predicted metalloprotease [General function prediction only]; Region: COG2321 439855008186 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 439855008187 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 439855008188 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 439855008189 ATP binding site [chemical binding]; other site 439855008190 active site 439855008191 substrate binding site [chemical binding]; other site 439855008192 lipoprotein; Provisional; Region: PRK11679 439855008193 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 439855008194 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 439855008195 dihydrodipicolinate synthase; Region: dapA; TIGR00674 439855008196 dimer interface [polypeptide binding]; other site 439855008197 active site 439855008198 catalytic residue [active] 439855008199 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 439855008200 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 439855008201 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 439855008202 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 439855008203 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 439855008204 catalytic triad [active] 439855008205 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 439855008206 4Fe-4S binding domain; Region: Fer4; pfam00037 439855008207 hydrogenase 4 subunit B; Validated; Region: PRK06521 439855008208 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855008209 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 439855008210 NADH dehydrogenase; Region: NADHdh; cl00469 439855008211 hydrogenase 4 subunit D; Validated; Region: PRK06525 439855008212 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855008213 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 439855008214 hydrogenase 4 subunit F; Validated; Region: PRK06458 439855008215 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855008216 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 439855008217 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 439855008218 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 439855008219 hydrogenase 4 subunit H; Validated; Region: PRK08222 439855008220 4Fe-4S binding domain; Region: Fer4; pfam00037 439855008221 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 439855008222 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 439855008223 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 439855008224 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 439855008225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855008226 Walker A motif; other site 439855008227 ATP binding site [chemical binding]; other site 439855008228 Walker B motif; other site 439855008229 arginine finger; other site 439855008230 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855008231 putative formate transporter; Provisional; Region: focB; PRK09713 439855008232 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 439855008233 Domain of unknown function DUF20; Region: UPF0118; pfam01594 439855008234 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 439855008235 Peptidase family M48; Region: Peptidase_M48; cl12018 439855008236 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 439855008237 ArsC family; Region: ArsC; pfam03960 439855008238 catalytic residues [active] 439855008239 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 439855008240 DNA replication initiation factor; Provisional; Region: PRK08084 439855008241 uracil transporter; Provisional; Region: PRK10720 439855008242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855008243 active site 439855008244 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 439855008245 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 439855008246 dimerization interface [polypeptide binding]; other site 439855008247 putative ATP binding site [chemical binding]; other site 439855008248 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 439855008249 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 439855008250 active site 439855008251 substrate binding site [chemical binding]; other site 439855008252 cosubstrate binding site; other site 439855008253 catalytic site [active] 439855008254 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 439855008255 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 439855008256 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 439855008257 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 439855008258 domain interface [polypeptide binding]; other site 439855008259 active site 439855008260 catalytic site [active] 439855008261 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 439855008262 putative active site [active] 439855008263 catalytic site [active] 439855008264 exopolyphosphatase; Provisional; Region: PRK10854 439855008265 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 439855008266 MASE1; Region: MASE1; pfam05231 439855008267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 439855008268 diguanylate cyclase; Region: GGDEF; smart00267 439855008269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855008270 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 439855008271 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 439855008272 GMP synthase; Reviewed; Region: guaA; PRK00074 439855008273 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 439855008274 AMP/PPi binding site [chemical binding]; other site 439855008275 candidate oxyanion hole; other site 439855008276 catalytic triad [active] 439855008277 potential glutamine specificity residues [chemical binding]; other site 439855008278 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 439855008279 ATP Binding subdomain [chemical binding]; other site 439855008280 Ligand Binding sites [chemical binding]; other site 439855008281 Dimerization subdomain; other site 439855008282 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 439855008283 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 439855008284 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 439855008285 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 439855008286 active site 439855008287 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 439855008288 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 439855008289 generic binding surface II; other site 439855008290 generic binding surface I; other site 439855008291 RatA-like protein; Provisional; Region: PRK15316 439855008292 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008293 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008294 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008295 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008296 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008297 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008298 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008299 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008300 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008301 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008302 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008303 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008304 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008305 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008306 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008307 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008308 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 439855008309 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 439855008310 intimin-like protein SinH; Provisional; Region: PRK15318 439855008311 intimin-like protein SinH; Provisional; Region: PRK15318 439855008312 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 439855008313 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 439855008314 GTP-binding protein Der; Reviewed; Region: PRK00093 439855008315 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 439855008316 G1 box; other site 439855008317 GTP/Mg2+ binding site [chemical binding]; other site 439855008318 Switch I region; other site 439855008319 G2 box; other site 439855008320 Switch II region; other site 439855008321 G3 box; other site 439855008322 G4 box; other site 439855008323 G5 box; other site 439855008324 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 439855008325 G1 box; other site 439855008326 GTP/Mg2+ binding site [chemical binding]; other site 439855008327 Switch I region; other site 439855008328 G2 box; other site 439855008329 G3 box; other site 439855008330 Switch II region; other site 439855008331 G4 box; other site 439855008332 G5 box; other site 439855008333 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 439855008334 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 439855008335 Trp docking motif [polypeptide binding]; other site 439855008336 active site 439855008337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 439855008338 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 439855008339 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 439855008340 dimer interface [polypeptide binding]; other site 439855008341 motif 1; other site 439855008342 active site 439855008343 motif 2; other site 439855008344 motif 3; other site 439855008345 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 439855008346 anticodon binding site; other site 439855008347 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 439855008348 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 439855008349 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 439855008350 cytoskeletal protein RodZ; Provisional; Region: PRK10856 439855008351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855008352 non-specific DNA binding site [nucleotide binding]; other site 439855008353 salt bridge; other site 439855008354 sequence-specific DNA binding site [nucleotide binding]; other site 439855008355 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 439855008356 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 439855008357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855008358 FeS/SAM binding site; other site 439855008359 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 439855008360 active site 439855008361 multimer interface [polypeptide binding]; other site 439855008362 penicillin-binding protein 1C; Provisional; Region: PRK11240 439855008363 Transglycosylase; Region: Transgly; pfam00912 439855008364 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 439855008365 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 439855008366 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 439855008367 MG2 domain; Region: A2M_N; pfam01835 439855008368 Alpha-2-macroglobulin family; Region: A2M; pfam00207 439855008369 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 439855008370 surface patch; other site 439855008371 thioester region; other site 439855008372 specificity defining residues; other site 439855008373 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 439855008374 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 439855008375 active site residue [active] 439855008376 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 439855008377 active site residue [active] 439855008378 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 439855008379 aminopeptidase B; Provisional; Region: PRK05015 439855008380 Peptidase; Region: DUF3663; pfam12404 439855008381 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 439855008382 interface (dimer of trimers) [polypeptide binding]; other site 439855008383 Substrate-binding/catalytic site; other site 439855008384 Zn-binding sites [ion binding]; other site 439855008385 hypothetical protein; Provisional; Region: PRK10721 439855008386 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 439855008387 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855008388 catalytic loop [active] 439855008389 iron binding site [ion binding]; other site 439855008390 chaperone protein HscA; Provisional; Region: hscA; PRK05183 439855008391 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 439855008392 nucleotide binding site [chemical binding]; other site 439855008393 putative NEF/HSP70 interaction site [polypeptide binding]; other site 439855008394 SBD interface [polypeptide binding]; other site 439855008395 co-chaperone HscB; Provisional; Region: hscB; PRK05014 439855008396 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 439855008397 HSP70 interaction site [polypeptide binding]; other site 439855008398 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 439855008399 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 439855008400 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 439855008401 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 439855008402 trimerization site [polypeptide binding]; other site 439855008403 active site 439855008404 cysteine desulfurase; Provisional; Region: PRK14012 439855008405 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 439855008406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855008407 catalytic residue [active] 439855008408 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 439855008409 Rrf2 family protein; Region: rrf2_super; TIGR00738 439855008410 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 439855008411 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 439855008412 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 439855008413 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 439855008414 active site 439855008415 dimerization interface [polypeptide binding]; other site 439855008416 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 439855008417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 439855008418 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 439855008419 PRD domain; Region: PRD; pfam00874 439855008420 PRD domain; Region: PRD; pfam00874 439855008421 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 439855008422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855008423 putative substrate translocation pore; other site 439855008424 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 439855008425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855008426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855008427 dimerization interface [polypeptide binding]; other site 439855008428 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 439855008429 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 439855008430 iron-sulfur cluster [ion binding]; other site 439855008431 [2Fe-2S] cluster binding site [ion binding]; other site 439855008432 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 439855008433 beta subunit interface [polypeptide binding]; other site 439855008434 alpha subunit interface [polypeptide binding]; other site 439855008435 active site 439855008436 substrate binding site [chemical binding]; other site 439855008437 Fe binding site [ion binding]; other site 439855008438 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 439855008439 inter-subunit interface; other site 439855008440 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 439855008441 [2Fe-2S] cluster binding site [ion binding]; other site 439855008442 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 439855008443 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 439855008444 NAD binding site [chemical binding]; other site 439855008445 active site 439855008446 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 439855008447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855008448 Predicted membrane protein [Function unknown]; Region: COG2259 439855008449 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 439855008450 active site 439855008451 catalytic residues [active] 439855008452 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855008453 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 439855008454 putative NAD(P) binding site [chemical binding]; other site 439855008455 catalytic Zn binding site [ion binding]; other site 439855008456 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855008457 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855008458 TM-ABC transporter signature motif; other site 439855008459 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 439855008460 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855008461 Walker A/P-loop; other site 439855008462 ATP binding site [chemical binding]; other site 439855008463 Q-loop/lid; other site 439855008464 ABC transporter signature motif; other site 439855008465 Walker B; other site 439855008466 D-loop; other site 439855008467 H-loop/switch region; other site 439855008468 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855008469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 439855008470 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 439855008471 ligand binding site [chemical binding]; other site 439855008472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855008473 TPR motif; other site 439855008474 Tetratricopeptide repeat; Region: TPR_16; pfam13432 439855008475 binding surface 439855008476 TPR repeat; Region: TPR_11; pfam13414 439855008477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855008478 TPR motif; other site 439855008479 binding surface 439855008480 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 439855008481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 439855008482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855008483 nucleotide binding site [chemical binding]; other site 439855008484 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 439855008485 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 439855008486 dimer interface [polypeptide binding]; other site 439855008487 active site 439855008488 glycine-pyridoxal phosphate binding site [chemical binding]; other site 439855008489 folate binding site [chemical binding]; other site 439855008490 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 439855008491 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 439855008492 heme-binding site [chemical binding]; other site 439855008493 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 439855008494 FAD binding pocket [chemical binding]; other site 439855008495 FAD binding motif [chemical binding]; other site 439855008496 phosphate binding motif [ion binding]; other site 439855008497 beta-alpha-beta structure motif; other site 439855008498 NAD binding pocket [chemical binding]; other site 439855008499 Heme binding pocket [chemical binding]; other site 439855008500 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 439855008501 Nitrogen regulatory protein P-II; Region: P-II; smart00938 439855008502 response regulator GlrR; Provisional; Region: PRK15115 439855008503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855008504 active site 439855008505 phosphorylation site [posttranslational modification] 439855008506 intermolecular recognition site; other site 439855008507 dimerization interface [polypeptide binding]; other site 439855008508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855008509 Walker A motif; other site 439855008510 ATP binding site [chemical binding]; other site 439855008511 Walker B motif; other site 439855008512 arginine finger; other site 439855008513 hypothetical protein; Provisional; Region: PRK10722 439855008514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 439855008515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855008516 dimer interface [polypeptide binding]; other site 439855008517 phosphorylation site [posttranslational modification] 439855008518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855008519 ATP binding site [chemical binding]; other site 439855008520 Mg2+ binding site [ion binding]; other site 439855008521 G-X-G motif; other site 439855008522 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 439855008523 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 439855008524 dimerization interface [polypeptide binding]; other site 439855008525 ATP binding site [chemical binding]; other site 439855008526 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 439855008527 dimerization interface [polypeptide binding]; other site 439855008528 ATP binding site [chemical binding]; other site 439855008529 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 439855008530 putative active site [active] 439855008531 catalytic triad [active] 439855008532 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 439855008533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855008534 substrate binding pocket [chemical binding]; other site 439855008535 membrane-bound complex binding site; other site 439855008536 hinge residues; other site 439855008537 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855008538 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855008539 catalytic residue [active] 439855008540 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 439855008541 nucleoside/Zn binding site; other site 439855008542 dimer interface [polypeptide binding]; other site 439855008543 catalytic motif [active] 439855008544 hypothetical protein; Provisional; Region: PRK11590 439855008545 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 439855008546 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 439855008547 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 439855008548 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 439855008549 putative active site [active] 439855008550 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 439855008551 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 439855008552 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 439855008553 active site 439855008554 hydrophilic channel; other site 439855008555 dimerization interface [polypeptide binding]; other site 439855008556 catalytic residues [active] 439855008557 active site lid [active] 439855008558 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 439855008559 Recombination protein O N terminal; Region: RecO_N; pfam11967 439855008560 Recombination protein O C terminal; Region: RecO_C; pfam02565 439855008561 GTPase Era; Reviewed; Region: era; PRK00089 439855008562 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 439855008563 G1 box; other site 439855008564 GTP/Mg2+ binding site [chemical binding]; other site 439855008565 Switch I region; other site 439855008566 G2 box; other site 439855008567 Switch II region; other site 439855008568 G3 box; other site 439855008569 G4 box; other site 439855008570 G5 box; other site 439855008571 KH domain; Region: KH_2; pfam07650 439855008572 ribonuclease III; Reviewed; Region: rnc; PRK00102 439855008573 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 439855008574 dimerization interface [polypeptide binding]; other site 439855008575 active site 439855008576 metal binding site [ion binding]; metal-binding site 439855008577 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 439855008578 dsRNA binding site [nucleotide binding]; other site 439855008579 signal peptidase I; Provisional; Region: PRK10861 439855008580 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 439855008581 Catalytic site [active] 439855008582 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 439855008583 GTP-binding protein LepA; Provisional; Region: PRK05433 439855008584 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 439855008585 G1 box; other site 439855008586 putative GEF interaction site [polypeptide binding]; other site 439855008587 GTP/Mg2+ binding site [chemical binding]; other site 439855008588 Switch I region; other site 439855008589 G2 box; other site 439855008590 G3 box; other site 439855008591 Switch II region; other site 439855008592 G4 box; other site 439855008593 G5 box; other site 439855008594 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 439855008595 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 439855008596 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 439855008597 SoxR reducing system protein RseC; Provisional; Region: PRK10862 439855008598 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 439855008599 anti-sigma E factor; Provisional; Region: rseB; PRK09455 439855008600 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 439855008601 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 439855008602 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 439855008603 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 439855008604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 439855008605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855008606 DNA binding residues [nucleotide binding] 439855008607 L-aspartate oxidase; Provisional; Region: PRK09077 439855008608 L-aspartate oxidase; Provisional; Region: PRK06175 439855008609 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 439855008610 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 439855008611 Methyltransferase domain; Region: Methyltransf_26; pfam13659 439855008612 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 439855008613 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 439855008614 ATP binding site [chemical binding]; other site 439855008615 Mg++ binding site [ion binding]; other site 439855008616 motif III; other site 439855008617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855008618 nucleotide binding region [chemical binding]; other site 439855008619 ATP-binding site [chemical binding]; other site 439855008620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855008621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855008622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 439855008623 dimerization interface [polypeptide binding]; other site 439855008624 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 439855008625 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 439855008626 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 439855008627 ligand binding site [chemical binding]; other site 439855008628 active site 439855008629 UGI interface [polypeptide binding]; other site 439855008630 catalytic site [active] 439855008631 putative methyltransferase; Provisional; Region: PRK10864 439855008632 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 439855008633 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 439855008634 thioredoxin 2; Provisional; Region: PRK10996 439855008635 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 439855008636 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 439855008637 catalytic residues [active] 439855008638 Uncharacterized conserved protein [Function unknown]; Region: COG3148 439855008639 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 439855008640 CoA binding domain; Region: CoA_binding_2; pfam13380 439855008641 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 439855008642 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 439855008643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 439855008644 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 439855008645 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 439855008646 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 439855008647 domain interface [polypeptide binding]; other site 439855008648 putative active site [active] 439855008649 catalytic site [active] 439855008650 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 439855008651 domain interface [polypeptide binding]; other site 439855008652 putative active site [active] 439855008653 catalytic site [active] 439855008654 lipoprotein; Provisional; Region: PRK10759 439855008655 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 439855008656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855008657 putative substrate translocation pore; other site 439855008658 protein disaggregation chaperone; Provisional; Region: PRK10865 439855008659 Clp amino terminal domain; Region: Clp_N; pfam02861 439855008660 Clp amino terminal domain; Region: Clp_N; pfam02861 439855008661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855008662 Walker A motif; other site 439855008663 ATP binding site [chemical binding]; other site 439855008664 Walker B motif; other site 439855008665 arginine finger; other site 439855008666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855008667 Walker A motif; other site 439855008668 ATP binding site [chemical binding]; other site 439855008669 Walker B motif; other site 439855008670 arginine finger; other site 439855008671 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 439855008672 hypothetical protein; Provisional; Region: PRK10723 439855008673 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 439855008674 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 439855008675 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855008676 RNA binding surface [nucleotide binding]; other site 439855008677 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 439855008678 active site 439855008679 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 439855008680 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 439855008681 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 439855008682 30S subunit binding site; other site 439855008683 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 439855008684 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 439855008685 Prephenate dehydratase; Region: PDT; pfam00800 439855008686 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 439855008687 putative L-Phe binding site [chemical binding]; other site 439855008688 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 439855008689 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 439855008690 prephenate dehydrogenase; Validated; Region: PRK08507 439855008691 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 439855008692 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 439855008693 lipoprotein; Provisional; Region: PRK11443 439855008694 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 439855008695 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 439855008696 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 439855008697 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855008698 metal binding site [ion binding]; metal-binding site 439855008699 active site 439855008700 I-site; other site 439855008701 putative outer membrane lipoprotein; Provisional; Region: PRK09967 439855008702 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855008703 ligand binding site [chemical binding]; other site 439855008704 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 439855008705 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 439855008706 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 439855008707 RimM N-terminal domain; Region: RimM; pfam01782 439855008708 PRC-barrel domain; Region: PRC; pfam05239 439855008709 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 439855008710 signal recognition particle protein; Provisional; Region: PRK10867 439855008711 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 439855008712 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 439855008713 P loop; other site 439855008714 GTP binding site [chemical binding]; other site 439855008715 Signal peptide binding domain; Region: SRP_SPB; pfam02978 439855008716 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 439855008717 hypothetical protein; Provisional; Region: PRK11573 439855008718 Domain of unknown function DUF21; Region: DUF21; pfam01595 439855008719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 439855008720 Transporter associated domain; Region: CorC_HlyC; smart01091 439855008721 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 439855008722 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 439855008723 dimer interface [polypeptide binding]; other site 439855008724 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 439855008725 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 439855008726 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 439855008727 recombination and repair protein; Provisional; Region: PRK10869 439855008728 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 439855008729 Walker A/P-loop; other site 439855008730 ATP binding site [chemical binding]; other site 439855008731 Q-loop/lid; other site 439855008732 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 439855008733 Q-loop/lid; other site 439855008734 ABC transporter signature motif; other site 439855008735 Walker B; other site 439855008736 D-loop; other site 439855008737 H-loop/switch region; other site 439855008738 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 439855008739 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 439855008740 hypothetical protein; Validated; Region: PRK01777 439855008741 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 439855008742 putative coenzyme Q binding site [chemical binding]; other site 439855008743 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 439855008744 SmpB-tmRNA interface; other site 439855008745 hypothetical protein; Provisional; Region: PRK09945 439855008746 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 439855008747 hypothetical protein; Provisional; Region: PRK09945 439855008748 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 439855008749 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 439855008750 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855008751 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 439855008752 active site 439855008753 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 439855008754 Ca binding site [ion binding]; other site 439855008755 catalytic site [active] 439855008756 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 439855008757 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 439855008758 substrate binding pocket [chemical binding]; other site 439855008759 active site 439855008760 iron coordination sites [ion binding]; other site 439855008761 Predicted dehydrogenase [General function prediction only]; Region: COG0579 439855008762 hydroxyglutarate oxidase; Provisional; Region: PRK11728 439855008763 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 439855008764 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 439855008765 tetramerization interface [polypeptide binding]; other site 439855008766 NAD(P) binding site [chemical binding]; other site 439855008767 catalytic residues [active] 439855008768 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 439855008769 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855008770 inhibitor-cofactor binding pocket; inhibition site 439855008771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855008772 catalytic residue [active] 439855008773 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 439855008774 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 439855008775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855008776 DNA-binding site [nucleotide binding]; DNA binding site 439855008777 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855008778 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 439855008779 bacterial OsmY and nodulation domain; Region: BON; smart00749 439855008780 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855008781 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 439855008782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855008783 dimerization interface [polypeptide binding]; other site 439855008784 putative DNA binding site [nucleotide binding]; other site 439855008785 putative Zn2+ binding site [ion binding]; other site 439855008786 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 439855008787 active site residue [active] 439855008788 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 439855008789 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 439855008790 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 439855008791 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 439855008792 hypothetical protein; Provisional; Region: PRK10556 439855008793 hypothetical protein; Provisional; Region: PRK10132 439855008794 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 439855008795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855008796 DNA-binding site [nucleotide binding]; DNA binding site 439855008797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855008798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855008799 homodimer interface [polypeptide binding]; other site 439855008800 catalytic residue [active] 439855008801 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 439855008802 Uncharacterized conserved protein [Function unknown]; Region: COG2128 439855008803 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 439855008804 catalytic residues [active] 439855008805 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 439855008806 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 439855008807 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 439855008808 Class I ribonucleotide reductase; Region: RNR_I; cd01679 439855008809 active site 439855008810 dimer interface [polypeptide binding]; other site 439855008811 catalytic residues [active] 439855008812 effector binding site; other site 439855008813 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 439855008814 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 439855008815 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 439855008816 dimer interface [polypeptide binding]; other site 439855008817 putative radical transfer pathway; other site 439855008818 diiron center [ion binding]; other site 439855008819 tyrosyl radical; other site 439855008820 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 439855008821 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 439855008822 Walker A/P-loop; other site 439855008823 ATP binding site [chemical binding]; other site 439855008824 Q-loop/lid; other site 439855008825 ABC transporter signature motif; other site 439855008826 Walker B; other site 439855008827 D-loop; other site 439855008828 H-loop/switch region; other site 439855008829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 439855008830 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 439855008831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855008832 dimer interface [polypeptide binding]; other site 439855008833 conserved gate region; other site 439855008834 putative PBP binding loops; other site 439855008835 ABC-ATPase subunit interface; other site 439855008836 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 439855008837 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 439855008838 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 439855008839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855008840 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 439855008841 putative L-valine exporter; Provisional; Region: PRK10408 439855008842 transcriptional repressor MprA; Provisional; Region: PRK10870 439855008843 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 439855008844 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 439855008845 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855008846 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855008847 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 439855008848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855008849 putative substrate translocation pore; other site 439855008850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855008851 S-ribosylhomocysteinase; Provisional; Region: PRK02260 439855008852 glutamate--cysteine ligase; Provisional; Region: PRK02107 439855008853 Predicted membrane protein [Function unknown]; Region: COG1238 439855008854 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 439855008855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855008856 motif II; other site 439855008857 carbon storage regulator; Provisional; Region: PRK01712 439855008858 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 439855008859 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 439855008860 motif 1; other site 439855008861 active site 439855008862 motif 2; other site 439855008863 motif 3; other site 439855008864 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 439855008865 DHHA1 domain; Region: DHHA1; pfam02272 439855008866 recombination regulator RecX; Reviewed; Region: recX; PRK00117 439855008867 recombinase A; Provisional; Region: recA; PRK09354 439855008868 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 439855008869 hexamer interface [polypeptide binding]; other site 439855008870 Walker A motif; other site 439855008871 ATP binding site [chemical binding]; other site 439855008872 Walker B motif; other site 439855008873 hypothetical protein; Validated; Region: PRK03661 439855008874 Transglycosylase SLT domain; Region: SLT_2; pfam13406 439855008875 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855008876 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855008877 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 439855008878 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 439855008879 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 439855008880 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 439855008881 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 439855008882 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 439855008883 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 439855008884 putative NAD(P) binding site [chemical binding]; other site 439855008885 active site 439855008886 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 439855008887 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 439855008888 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 439855008889 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855008890 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 439855008891 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 439855008892 putative active site [active] 439855008893 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 439855008894 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 439855008895 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 439855008896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855008897 Walker A motif; other site 439855008898 ATP binding site [chemical binding]; other site 439855008899 Walker B motif; other site 439855008900 arginine finger; other site 439855008901 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 439855008902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 439855008903 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 439855008904 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 439855008905 iron binding site [ion binding]; other site 439855008906 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 439855008907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855008908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855008909 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 439855008910 Acylphosphatase; Region: Acylphosphatase; pfam00708 439855008911 HypF finger; Region: zf-HYPF; pfam07503 439855008912 HypF finger; Region: zf-HYPF; pfam07503 439855008913 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 439855008914 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 439855008915 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 439855008916 Transcriptional regulators [Transcription]; Region: PurR; COG1609 439855008917 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855008918 DNA binding site [nucleotide binding] 439855008919 domain linker motif; other site 439855008920 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 439855008921 dimerization interface (closed form) [polypeptide binding]; other site 439855008922 ligand binding site [chemical binding]; other site 439855008923 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 439855008924 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855008925 active site turn [active] 439855008926 phosphorylation site [posttranslational modification] 439855008927 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 439855008928 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 439855008929 beta-galactosidase; Region: BGL; TIGR03356 439855008930 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 439855008931 nickel binding site [ion binding]; other site 439855008932 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 439855008933 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 439855008934 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 439855008935 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855008936 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 439855008937 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 439855008938 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 439855008939 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 439855008940 NADH dehydrogenase; Region: NADHdh; cl00469 439855008941 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 439855008942 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 439855008943 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 439855008944 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 439855008945 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 439855008946 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 439855008947 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 439855008948 hydrogenase assembly chaperone; Provisional; Region: PRK10409 439855008949 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 439855008950 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 439855008951 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 439855008952 dimerization interface [polypeptide binding]; other site 439855008953 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 439855008954 ATP binding site [chemical binding]; other site 439855008955 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 439855008956 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 439855008957 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 439855008958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855008959 Walker A motif; other site 439855008960 ATP binding site [chemical binding]; other site 439855008961 Walker B motif; other site 439855008962 arginine finger; other site 439855008963 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 439855008964 molybdenum-pterin binding domain; Region: Mop; TIGR00638 439855008965 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 439855008966 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 439855008967 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 439855008968 MutS domain I; Region: MutS_I; pfam01624 439855008969 MutS domain II; Region: MutS_II; pfam05188 439855008970 MutS domain III; Region: MutS_III; pfam05192 439855008971 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 439855008972 Walker A/P-loop; other site 439855008973 ATP binding site [chemical binding]; other site 439855008974 Q-loop/lid; other site 439855008975 ABC transporter signature motif; other site 439855008976 Walker B; other site 439855008977 D-loop; other site 439855008978 H-loop/switch region; other site 439855008979 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 439855008980 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 439855008981 active site 439855008982 metal binding site [ion binding]; metal-binding site 439855008983 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 439855008984 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 439855008985 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 439855008986 Flavoprotein; Region: Flavoprotein; pfam02441 439855008987 MarR family; Region: MarR_2; cl17246 439855008988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 439855008989 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 439855008990 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 439855008991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 439855008992 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 439855008993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855008994 DNA binding residues [nucleotide binding] 439855008995 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 439855008996 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855008997 Peptidase family M23; Region: Peptidase_M23; pfam01551 439855008998 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 439855008999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855009000 S-adenosylmethionine binding site [chemical binding]; other site 439855009001 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 439855009002 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 439855009003 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 439855009004 Permutation of conserved domain; other site 439855009005 active site 439855009006 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 439855009007 homotrimer interaction site [polypeptide binding]; other site 439855009008 zinc binding site [ion binding]; other site 439855009009 CDP-binding sites; other site 439855009010 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 439855009011 substrate binding site; other site 439855009012 dimer interface; other site 439855009013 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 439855009014 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 439855009015 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 439855009016 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 439855009017 ligand-binding site [chemical binding]; other site 439855009018 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 439855009019 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 439855009020 CysD dimerization site [polypeptide binding]; other site 439855009021 G1 box; other site 439855009022 putative GEF interaction site [polypeptide binding]; other site 439855009023 GTP/Mg2+ binding site [chemical binding]; other site 439855009024 Switch I region; other site 439855009025 G2 box; other site 439855009026 G3 box; other site 439855009027 Switch II region; other site 439855009028 G4 box; other site 439855009029 G5 box; other site 439855009030 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 439855009031 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 439855009032 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 439855009033 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 439855009034 Active Sites [active] 439855009035 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 439855009036 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 439855009037 metal binding site [ion binding]; metal-binding site 439855009038 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 439855009039 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 439855009040 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 439855009041 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 439855009042 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 439855009043 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 439855009044 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 439855009045 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 439855009046 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 439855009047 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 439855009048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 439855009049 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 439855009050 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 439855009051 Active Sites [active] 439855009052 sulfite reductase subunit beta; Provisional; Region: PRK13504 439855009053 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 439855009054 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 439855009055 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 439855009056 Flavodoxin; Region: Flavodoxin_1; pfam00258 439855009057 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 439855009058 FAD binding pocket [chemical binding]; other site 439855009059 FAD binding motif [chemical binding]; other site 439855009060 catalytic residues [active] 439855009061 NAD binding pocket [chemical binding]; other site 439855009062 phosphate binding motif [ion binding]; other site 439855009063 beta-alpha-beta structure motif; other site 439855009064 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 439855009065 homohexamer interface [polypeptide binding]; other site 439855009066 putative substrate stabilizing pore; other site 439855009067 pterin binding site; other site 439855009068 putative oxidoreductase FixC; Provisional; Region: PRK10157 439855009069 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 439855009070 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 439855009071 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 439855009072 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 439855009073 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 439855009074 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 439855009075 Ligand binding site [chemical binding]; other site 439855009076 Electron transfer flavoprotein domain; Region: ETF; pfam01012 439855009077 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 439855009078 benzoate transport; Region: 2A0115; TIGR00895 439855009079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009080 putative substrate translocation pore; other site 439855009081 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 439855009082 FAD binding domain; Region: FAD_binding_4; pfam01565 439855009083 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 439855009084 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 439855009085 NADP binding site [chemical binding]; other site 439855009086 homodimer interface [polypeptide binding]; other site 439855009087 active site 439855009088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009090 putative substrate translocation pore; other site 439855009091 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 439855009092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 439855009093 nucleotide binding site [chemical binding]; other site 439855009094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855009095 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 439855009096 putative substrate binding site [chemical binding]; other site 439855009097 putative ATP binding site [chemical binding]; other site 439855009098 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 439855009099 trimer interface; other site 439855009100 sugar binding site [chemical binding]; other site 439855009101 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 439855009102 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855009103 active site turn [active] 439855009104 phosphorylation site [posttranslational modification] 439855009105 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 439855009106 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 439855009107 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 439855009108 substrate binding [chemical binding]; other site 439855009109 active site 439855009110 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 439855009111 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 439855009112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855009113 DNA binding site [nucleotide binding] 439855009114 domain linker motif; other site 439855009115 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 439855009116 dimerization interface [polypeptide binding]; other site 439855009117 ligand binding site [chemical binding]; other site 439855009118 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 439855009119 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 439855009120 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 439855009121 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 439855009122 Repair protein; Region: Repair_PSII; pfam04536 439855009123 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 439855009124 Repair protein; Region: Repair_PSII; pfam04536 439855009125 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 439855009126 Repair protein; Region: Repair_PSII; pfam04536 439855009127 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 439855009128 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 439855009129 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855009130 enolase; Provisional; Region: eno; PRK00077 439855009131 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 439855009132 dimer interface [polypeptide binding]; other site 439855009133 metal binding site [ion binding]; metal-binding site 439855009134 substrate binding pocket [chemical binding]; other site 439855009135 CTP synthetase; Validated; Region: pyrG; PRK05380 439855009136 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 439855009137 Catalytic site [active] 439855009138 active site 439855009139 UTP binding site [chemical binding]; other site 439855009140 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 439855009141 active site 439855009142 putative oxyanion hole; other site 439855009143 catalytic triad [active] 439855009144 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 439855009145 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 439855009146 homodimer interface [polypeptide binding]; other site 439855009147 metal binding site [ion binding]; metal-binding site 439855009148 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 439855009149 homodimer interface [polypeptide binding]; other site 439855009150 active site 439855009151 putative chemical substrate binding site [chemical binding]; other site 439855009152 metal binding site [ion binding]; metal-binding site 439855009153 toxin MazF; Provisional; Region: PRK09907 439855009154 antitoxin MazE; Provisional; Region: PRK09798 439855009155 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 439855009156 HD domain; Region: HD_4; pfam13328 439855009157 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 439855009158 synthetase active site [active] 439855009159 NTP binding site [chemical binding]; other site 439855009160 metal binding site [ion binding]; metal-binding site 439855009161 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 439855009162 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 439855009163 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 439855009164 TRAM domain; Region: TRAM; pfam01938 439855009165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855009166 S-adenosylmethionine binding site [chemical binding]; other site 439855009167 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 439855009168 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 439855009169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855009170 dimerization interface [polypeptide binding]; other site 439855009171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855009172 dimer interface [polypeptide binding]; other site 439855009173 phosphorylation site [posttranslational modification] 439855009174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855009175 ATP binding site [chemical binding]; other site 439855009176 Mg2+ binding site [ion binding]; other site 439855009177 G-X-G motif; other site 439855009178 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 439855009179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855009180 active site 439855009181 phosphorylation site [posttranslational modification] 439855009182 intermolecular recognition site; other site 439855009183 dimerization interface [polypeptide binding]; other site 439855009184 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 439855009185 putative binding surface; other site 439855009186 active site 439855009187 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 439855009188 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 439855009189 active site 439855009190 tetramer interface [polypeptide binding]; other site 439855009191 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 439855009192 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 439855009193 active site 439855009194 tetramer interface [polypeptide binding]; other site 439855009195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009196 D-galactonate transporter; Region: 2A0114; TIGR00893 439855009197 putative substrate translocation pore; other site 439855009198 flavodoxin; Provisional; Region: PRK08105 439855009199 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 439855009200 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 439855009201 probable active site [active] 439855009202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 439855009203 SecY interacting protein Syd; Provisional; Region: PRK04968 439855009204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 439855009205 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 439855009206 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 439855009207 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 439855009208 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 439855009209 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 439855009210 serine transporter; Region: stp; TIGR00814 439855009211 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 439855009212 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 439855009213 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 439855009214 flap endonuclease-like protein; Provisional; Region: PRK09482 439855009215 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 439855009216 active site 439855009217 metal binding site 1 [ion binding]; metal-binding site 439855009218 putative 5' ssDNA interaction site; other site 439855009219 metal binding site 3; metal-binding site 439855009220 metal binding site 2 [ion binding]; metal-binding site 439855009221 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 439855009222 putative DNA binding site [nucleotide binding]; other site 439855009223 putative metal binding site [ion binding]; other site 439855009224 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 439855009225 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 439855009226 dimer interface [polypeptide binding]; other site 439855009227 active site 439855009228 metal binding site [ion binding]; metal-binding site 439855009229 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 439855009230 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 439855009231 intersubunit interface [polypeptide binding]; other site 439855009232 active site 439855009233 Zn2+ binding site [ion binding]; other site 439855009234 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 439855009235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009236 putative substrate translocation pore; other site 439855009237 L-fucose isomerase; Provisional; Region: fucI; PRK10991 439855009238 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 439855009239 hexamer (dimer of trimers) interface [polypeptide binding]; other site 439855009240 trimer interface [polypeptide binding]; other site 439855009241 substrate binding site [chemical binding]; other site 439855009242 Mn binding site [ion binding]; other site 439855009243 L-fuculokinase; Provisional; Region: PRK10331 439855009244 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 439855009245 nucleotide binding site [chemical binding]; other site 439855009246 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 439855009247 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 439855009248 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 439855009249 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855009250 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 439855009251 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 439855009252 hypothetical protein; Provisional; Region: PRK10873 439855009253 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 439855009254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855009255 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 439855009256 dimerization interface [polypeptide binding]; other site 439855009257 substrate binding pocket [chemical binding]; other site 439855009258 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 439855009259 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 439855009260 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 439855009261 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855009262 catalytic residue [active] 439855009263 CsdA-binding activator; Provisional; Region: PRK15019 439855009264 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 439855009265 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 439855009266 putative ATP binding site [chemical binding]; other site 439855009267 putative substrate interface [chemical binding]; other site 439855009268 murein transglycosylase A; Provisional; Region: mltA; PRK11162 439855009269 MltA specific insert domain; Region: MltA; pfam03562 439855009270 3D domain; Region: 3D; pfam06725 439855009271 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 439855009272 putative ligand binding site [chemical binding]; other site 439855009273 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 439855009274 putative NAD binding site [chemical binding]; other site 439855009275 catalytic site [active] 439855009276 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 439855009277 putative active site [active] 439855009278 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 439855009279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855009280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855009281 homodimer interface [polypeptide binding]; other site 439855009282 catalytic residue [active] 439855009283 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 439855009284 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 439855009285 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855009286 active site turn [active] 439855009287 phosphorylation site [posttranslational modification] 439855009288 CAT RNA binding domain; Region: CAT_RBD; pfam03123 439855009289 PRD domain; Region: PRD; pfam00874 439855009290 PRD domain; Region: PRD; pfam00874 439855009291 AMIN domain; Region: AMIN; pfam11741 439855009292 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 439855009293 active site 439855009294 metal binding site [ion binding]; metal-binding site 439855009295 N-acetylglutamate synthase; Validated; Region: PRK05279 439855009296 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 439855009297 putative feedback inhibition sensing region; other site 439855009298 putative nucleotide binding site [chemical binding]; other site 439855009299 putative substrate binding site [chemical binding]; other site 439855009300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855009301 Coenzyme A binding pocket [chemical binding]; other site 439855009302 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 439855009303 AAA domain; Region: AAA_30; pfam13604 439855009304 Family description; Region: UvrD_C_2; pfam13538 439855009305 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 439855009306 protease3; Provisional; Region: PRK15101 439855009307 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 439855009308 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 439855009309 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 439855009310 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 439855009311 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 439855009312 hypothetical protein; Provisional; Region: PRK10332 439855009313 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 439855009314 hypothetical protein; Provisional; Region: PRK11521 439855009315 hypothetical protein; Provisional; Region: PRK10557 439855009316 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 439855009317 hypothetical protein; Provisional; Region: PRK10506 439855009318 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 439855009319 thymidylate synthase; Reviewed; Region: thyA; PRK01827 439855009320 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 439855009321 dimerization interface [polypeptide binding]; other site 439855009322 active site 439855009323 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 439855009324 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 439855009325 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 439855009326 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 439855009327 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855009328 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 439855009329 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 439855009330 putative active site [active] 439855009331 Ap4A binding site [chemical binding]; other site 439855009332 nudix motif; other site 439855009333 putative metal binding site [ion binding]; other site 439855009334 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 439855009335 putative DNA-binding cleft [nucleotide binding]; other site 439855009336 putative DNA clevage site; other site 439855009337 molecular lever; other site 439855009338 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 439855009339 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 439855009340 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855009341 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855009342 active site 439855009343 catalytic tetrad [active] 439855009344 lysophospholipid transporter LplT; Provisional; Region: PRK11195 439855009345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009346 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 439855009347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 439855009348 putative acyl-acceptor binding pocket; other site 439855009349 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 439855009350 acyl-activating enzyme (AAE) consensus motif; other site 439855009351 putative AMP binding site [chemical binding]; other site 439855009352 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 439855009353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855009354 DNA binding site [nucleotide binding] 439855009355 domain linker motif; other site 439855009356 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 439855009357 dimerization interface (closed form) [polypeptide binding]; other site 439855009358 ligand binding site [chemical binding]; other site 439855009359 diaminopimelate decarboxylase; Provisional; Region: PRK11165 439855009360 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 439855009361 active site 439855009362 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855009363 substrate binding site [chemical binding]; other site 439855009364 catalytic residues [active] 439855009365 dimer interface [polypeptide binding]; other site 439855009366 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 439855009367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855009368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855009369 dimerization interface [polypeptide binding]; other site 439855009370 putative racemase; Provisional; Region: PRK10200 439855009371 aspartate racemase; Region: asp_race; TIGR00035 439855009372 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 439855009373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009374 putative substrate translocation pore; other site 439855009375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009376 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 439855009377 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 439855009378 NADP binding site [chemical binding]; other site 439855009379 homodimer interface [polypeptide binding]; other site 439855009380 active site 439855009381 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 439855009382 putative acyltransferase; Provisional; Region: PRK05790 439855009383 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 439855009384 dimer interface [polypeptide binding]; other site 439855009385 active site 439855009386 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 439855009387 serine transporter; Region: stp; TIGR00814 439855009388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 439855009389 DNA binding residues [nucleotide binding] 439855009390 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 439855009391 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 439855009392 Peptidase family M23; Region: Peptidase_M23; pfam01551 439855009393 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 439855009394 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 439855009395 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 439855009396 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 439855009397 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 439855009398 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 439855009399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 439855009400 catalytic loop [active] 439855009401 iron binding site [ion binding]; other site 439855009402 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 439855009403 GAF domain; Region: GAF; cl17456 439855009404 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 439855009405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855009406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855009407 Walker A motif; other site 439855009408 ATP binding site [chemical binding]; other site 439855009409 Walker B motif; other site 439855009410 arginine finger; other site 439855009411 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855009412 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 439855009413 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 439855009414 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 439855009415 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 439855009416 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 439855009417 catalytic residue [active] 439855009418 peptidase; Reviewed; Region: PRK13004 439855009419 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 439855009420 putative metal binding site [ion binding]; other site 439855009421 putative dimer interface [polypeptide binding]; other site 439855009422 D-hydantoinase; Region: D-hydantoinase; TIGR02033 439855009423 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 439855009424 tetramer interface [polypeptide binding]; other site 439855009425 active site 439855009426 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 439855009427 carbamate kinase; Reviewed; Region: PRK12686 439855009428 putative substrate binding site [chemical binding]; other site 439855009429 homodimer interface [polypeptide binding]; other site 439855009430 nucleotide binding site [chemical binding]; other site 439855009431 nucleotide binding site [chemical binding]; other site 439855009432 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 439855009433 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 439855009434 XdhC Rossmann domain; Region: XdhC_C; pfam13478 439855009435 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 439855009436 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 439855009437 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 439855009438 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 439855009439 Ligand binding site; other site 439855009440 metal-binding site 439855009441 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 439855009442 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 439855009443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855009444 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 439855009445 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 439855009446 active site 439855009447 putative substrate binding pocket [chemical binding]; other site 439855009448 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 439855009449 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 439855009450 putative hypoxanthine oxidase; Provisional; Region: PRK09800 439855009451 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 439855009452 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 439855009453 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 439855009454 uracil-xanthine permease; Region: ncs2; TIGR00801 439855009455 guanine deaminase; Provisional; Region: PRK09228 439855009456 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 439855009457 active site 439855009458 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 439855009459 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 439855009460 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 439855009461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 439855009462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855009463 xanthine permease; Region: pbuX; TIGR03173 439855009464 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 439855009465 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 439855009466 active site 439855009467 metal binding site [ion binding]; metal-binding site 439855009468 nudix motif; other site 439855009469 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 439855009470 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 439855009471 dimer interface [polypeptide binding]; other site 439855009472 putative anticodon binding site; other site 439855009473 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 439855009474 motif 1; other site 439855009475 active site 439855009476 motif 2; other site 439855009477 motif 3; other site 439855009478 peptide chain release factor 2; Validated; Region: prfB; PRK00578 439855009479 This domain is found in peptide chain release factors; Region: PCRF; smart00937 439855009480 RF-1 domain; Region: RF-1; pfam00472 439855009481 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 439855009482 DHH family; Region: DHH; pfam01368 439855009483 DHHA1 domain; Region: DHHA1; pfam02272 439855009484 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 439855009485 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 439855009486 dimerization domain [polypeptide binding]; other site 439855009487 dimer interface [polypeptide binding]; other site 439855009488 catalytic residues [active] 439855009489 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 439855009490 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 439855009491 active site 439855009492 Int/Topo IB signature motif; other site 439855009493 flavodoxin FldB; Provisional; Region: PRK12359 439855009494 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 439855009495 hypothetical protein; Provisional; Region: PRK10878 439855009496 putative global regulator; Reviewed; Region: PRK09559 439855009497 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 439855009498 hemolysin; Provisional; Region: PRK15087 439855009499 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 439855009500 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 439855009501 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 439855009502 beta-galactosidase; Region: BGL; TIGR03356 439855009503 glycine dehydrogenase; Provisional; Region: PRK05367 439855009504 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 439855009505 tetramer interface [polypeptide binding]; other site 439855009506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855009507 catalytic residue [active] 439855009508 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 439855009509 tetramer interface [polypeptide binding]; other site 439855009510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855009511 catalytic residue [active] 439855009512 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 439855009513 lipoyl attachment site [posttranslational modification]; other site 439855009514 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 439855009515 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 439855009516 oxidoreductase; Provisional; Region: PRK08013 439855009517 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 439855009518 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 439855009519 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 439855009520 proline aminopeptidase P II; Provisional; Region: PRK10879 439855009521 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 439855009522 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 439855009523 active site 439855009524 hypothetical protein; Reviewed; Region: PRK01736 439855009525 Z-ring-associated protein; Provisional; Region: PRK10972 439855009526 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 439855009527 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 439855009528 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 439855009529 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 439855009530 ligand binding site [chemical binding]; other site 439855009531 NAD binding site [chemical binding]; other site 439855009532 tetramer interface [polypeptide binding]; other site 439855009533 catalytic site [active] 439855009534 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 439855009535 L-serine binding site [chemical binding]; other site 439855009536 ACT domain interface; other site 439855009537 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 439855009538 tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855009539 active site 439855009540 dimer interface [polypeptide binding]; other site 439855009541 LysR family transcriptional regulator; Provisional; Region: PRK14997 439855009542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855009543 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 439855009544 putative effector binding pocket; other site 439855009545 dimerization interface [polypeptide binding]; other site 439855009546 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 439855009547 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 439855009548 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855009549 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 439855009550 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 439855009551 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 439855009552 FAD binding pocket [chemical binding]; other site 439855009553 FAD binding motif [chemical binding]; other site 439855009554 phosphate binding motif [ion binding]; other site 439855009555 beta-alpha-beta structure motif; other site 439855009556 NAD binding pocket [chemical binding]; other site 439855009557 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 439855009558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855009559 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 439855009560 putative dimerization interface [polypeptide binding]; other site 439855009561 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 439855009562 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 439855009563 active site 439855009564 substrate binding site [chemical binding]; other site 439855009565 coenzyme B12 binding site [chemical binding]; other site 439855009566 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 439855009567 B12 binding site [chemical binding]; other site 439855009568 cobalt ligand [ion binding]; other site 439855009569 membrane ATPase/protein kinase; Provisional; Region: PRK09435 439855009570 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 439855009571 Walker A; other site 439855009572 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 439855009573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 439855009574 substrate binding site [chemical binding]; other site 439855009575 oxyanion hole (OAH) forming residues; other site 439855009576 trimer interface [polypeptide binding]; other site 439855009577 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 439855009578 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 439855009579 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 439855009580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855009581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855009582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855009583 dimerization interface [polypeptide binding]; other site 439855009584 Uncharacterized conserved protein [Function unknown]; Region: COG2968 439855009585 oxidative stress defense protein; Provisional; Region: PRK11087 439855009586 arginine exporter protein; Provisional; Region: PRK09304 439855009587 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 439855009588 mechanosensitive channel MscS; Provisional; Region: PRK10334 439855009589 Mechanosensitive ion channel; Region: MS_channel; pfam00924 439855009590 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 439855009591 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 439855009592 active site 439855009593 intersubunit interface [polypeptide binding]; other site 439855009594 zinc binding site [ion binding]; other site 439855009595 Na+ binding site [ion binding]; other site 439855009596 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 439855009597 Phosphoglycerate kinase; Region: PGK; pfam00162 439855009598 substrate binding site [chemical binding]; other site 439855009599 hinge regions; other site 439855009600 ADP binding site [chemical binding]; other site 439855009601 catalytic site [active] 439855009602 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 439855009603 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 439855009604 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 439855009605 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 439855009606 trimer interface [polypeptide binding]; other site 439855009607 putative Zn binding site [ion binding]; other site 439855009608 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 439855009609 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 439855009610 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 439855009611 Walker A/P-loop; other site 439855009612 ATP binding site [chemical binding]; other site 439855009613 Q-loop/lid; other site 439855009614 ABC transporter signature motif; other site 439855009615 Walker B; other site 439855009616 D-loop; other site 439855009617 H-loop/switch region; other site 439855009618 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 439855009619 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 439855009620 Walker A/P-loop; other site 439855009621 ATP binding site [chemical binding]; other site 439855009622 Q-loop/lid; other site 439855009623 ABC transporter signature motif; other site 439855009624 Walker B; other site 439855009625 H-loop/switch region; other site 439855009626 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 439855009627 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 439855009628 active site 439855009629 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 439855009630 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 439855009631 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 439855009632 putative active site [active] 439855009633 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 439855009634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855009635 putative NAD(P) binding site [chemical binding]; other site 439855009636 catalytic Zn binding site [ion binding]; other site 439855009637 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855009638 active site 439855009639 phosphorylation site [posttranslational modification] 439855009640 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 439855009641 SPFH domain / Band 7 family; Region: Band_7; pfam01145 439855009642 transketolase; Reviewed; Region: PRK12753 439855009643 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 439855009644 TPP-binding site [chemical binding]; other site 439855009645 dimer interface [polypeptide binding]; other site 439855009646 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 439855009647 PYR/PP interface [polypeptide binding]; other site 439855009648 dimer interface [polypeptide binding]; other site 439855009649 TPP binding site [chemical binding]; other site 439855009650 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 439855009651 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 439855009652 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 439855009653 agmatinase; Region: agmatinase; TIGR01230 439855009654 oligomer interface [polypeptide binding]; other site 439855009655 putative active site [active] 439855009656 Mn binding site [ion binding]; other site 439855009657 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 439855009658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 439855009659 dimer interface [polypeptide binding]; other site 439855009660 active site 439855009661 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855009662 catalytic residues [active] 439855009663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 439855009664 Virulence promoting factor; Region: YqgB; pfam11036 439855009665 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 439855009666 S-adenosylmethionine synthetase; Validated; Region: PRK05250 439855009667 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 439855009668 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 439855009669 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 439855009670 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 439855009671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009672 putative substrate translocation pore; other site 439855009673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009674 hypothetical protein; Provisional; Region: PRK04860 439855009675 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 439855009676 DNA-specific endonuclease I; Provisional; Region: PRK15137 439855009677 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 439855009678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 439855009679 RNA methyltransferase, RsmE family; Region: TIGR00046 439855009680 glutathione synthetase; Provisional; Region: PRK05246 439855009681 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 439855009682 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 439855009683 hypothetical protein; Validated; Region: PRK00228 439855009684 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 439855009685 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 439855009686 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 439855009687 Walker A motif; other site 439855009688 ATP binding site [chemical binding]; other site 439855009689 Walker B motif; other site 439855009690 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 439855009691 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855009692 catalytic residue [active] 439855009693 YGGT family; Region: YGGT; pfam02325 439855009694 YGGT family; Region: YGGT; pfam02325 439855009695 hypothetical protein; Validated; Region: PRK05090 439855009696 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 439855009697 active site 439855009698 dimerization interface [polypeptide binding]; other site 439855009699 HemN family oxidoreductase; Provisional; Region: PRK05660 439855009700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855009701 FeS/SAM binding site; other site 439855009702 HemN C-terminal domain; Region: HemN_C; pfam06969 439855009703 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 439855009704 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 439855009705 homodimer interface [polypeptide binding]; other site 439855009706 active site 439855009707 hypothetical protein; Provisional; Region: PRK10626 439855009708 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 439855009709 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 439855009710 hypothetical protein; Provisional; Region: PRK11702 439855009711 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 439855009712 adenine DNA glycosylase; Provisional; Region: PRK10880 439855009713 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 439855009714 minor groove reading motif; other site 439855009715 helix-hairpin-helix signature motif; other site 439855009716 substrate binding pocket [chemical binding]; other site 439855009717 active site 439855009718 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 439855009719 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 439855009720 DNA binding and oxoG recognition site [nucleotide binding] 439855009721 oxidative damage protection protein; Provisional; Region: PRK05408 439855009722 murein transglycosylase C; Provisional; Region: mltC; PRK11671 439855009723 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 439855009724 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855009725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855009726 catalytic residue [active] 439855009727 nucleoside transporter; Region: 2A0110; TIGR00889 439855009728 ornithine decarboxylase; Provisional; Region: PRK13578 439855009729 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 439855009730 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 439855009731 homodimer interface [polypeptide binding]; other site 439855009732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855009733 catalytic residue [active] 439855009734 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 439855009735 integrase; Provisional; Region: PRK09692 439855009736 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 439855009737 active site 439855009738 Int/Topo IB signature motif; other site 439855009739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855009740 DNA binding site [nucleotide binding] 439855009741 domain linker motif; other site 439855009742 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 439855009743 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 439855009744 ligand binding site [chemical binding]; other site 439855009745 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 439855009746 Melibiase; Region: Melibiase; pfam02065 439855009747 galactoside permease; Reviewed; Region: lacY; PRK09528 439855009748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009749 putative substrate translocation pore; other site 439855009750 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 439855009751 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 439855009752 substrate binding [chemical binding]; other site 439855009753 active site 439855009754 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 439855009755 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 439855009756 Integrase core domain; Region: rve_3; pfam13683 439855009757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 439855009758 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 439855009759 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 439855009760 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 439855009761 Transposase; Region: HTH_Tnp_1; pfam01527 439855009762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855009763 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 439855009764 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 439855009765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 439855009766 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 439855009767 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 439855009768 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 439855009769 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 439855009770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855009771 N-terminal plug; other site 439855009772 ligand-binding site [chemical binding]; other site 439855009773 Homeodomain-like domain; Region: HTH_23; pfam13384 439855009774 Winged helix-turn helix; Region: HTH_29; pfam13551 439855009775 Homeodomain-like domain; Region: HTH_32; pfam13565 439855009776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 439855009777 DDE superfamily endonuclease; Region: DDE_3; pfam13358 439855009778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 439855009779 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 439855009780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855009781 Transposase; Region: HTH_Tnp_1; pfam01527 439855009782 AMIN domain; Region: AMIN; pfam11741 439855009783 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 439855009784 active site 439855009785 metal binding site [ion binding]; metal-binding site 439855009786 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 439855009787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855009788 Walker A motif; other site 439855009789 ATP binding site [chemical binding]; other site 439855009790 Walker B motif; other site 439855009791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 439855009792 Integrase core domain; Region: rve; pfam00665 439855009793 Integrase core domain; Region: rve_3; cl15866 439855009794 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 439855009795 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 439855009796 ParB-like nuclease domain; Region: ParBc; cl02129 439855009797 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 439855009798 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 439855009799 Active Sites [active] 439855009800 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 439855009801 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 439855009802 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 439855009803 E-class dimer interface [polypeptide binding]; other site 439855009804 P-class dimer interface [polypeptide binding]; other site 439855009805 active site 439855009806 Cu2+ binding site [ion binding]; other site 439855009807 Zn2+ binding site [ion binding]; other site 439855009808 IS2 repressor TnpA; Reviewed; Region: PRK09413 439855009809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855009810 IS2 transposase TnpB; Reviewed; Region: PRK09409 439855009811 HTH-like domain; Region: HTH_21; pfam13276 439855009812 Integrase core domain; Region: rve; pfam00665 439855009813 Integrase core domain; Region: rve_3; pfam13683 439855009814 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 439855009815 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 439855009816 metal binding site [ion binding]; metal-binding site 439855009817 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 439855009818 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 439855009819 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 439855009820 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855009821 ABC-ATPase subunit interface; other site 439855009822 dimer interface [polypeptide binding]; other site 439855009823 putative PBP binding regions; other site 439855009824 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 439855009825 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855009826 ABC-ATPase subunit interface; other site 439855009827 dimer interface [polypeptide binding]; other site 439855009828 putative PBP binding regions; other site 439855009829 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 439855009830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855009831 N-terminal plug; other site 439855009832 ligand-binding site [chemical binding]; other site 439855009833 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 439855009834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855009835 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 439855009836 IucA / IucC family; Region: IucA_IucC; pfam04183 439855009837 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 439855009838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 439855009839 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 439855009840 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 439855009841 IucA / IucC family; Region: IucA_IucC; pfam04183 439855009842 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 439855009843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855009844 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855009845 putative substrate translocation pore; other site 439855009846 YadA-like C-terminal region; Region: YadA; pfam03895 439855009847 TIGR01619 family protein; Region: hyp_HI0040 439855009848 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 439855009849 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 439855009850 Predicted GTPase [General function prediction only]; Region: COG3596 439855009851 YfjP GTPase; Region: YfjP; cd11383 439855009852 G1 box; other site 439855009853 GTP/Mg2+ binding site [chemical binding]; other site 439855009854 Switch I region; other site 439855009855 G2 box; other site 439855009856 Switch II region; other site 439855009857 G3 box; other site 439855009858 G4 box; other site 439855009859 G5 box; other site 439855009860 HTH domain; Region: HTH_11; cl17392 439855009861 WYL domain; Region: WYL; pfam13280 439855009862 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 439855009863 Domain of unknown function (DUF932); Region: DUF932; pfam06067 439855009864 Antirestriction protein; Region: Antirestrict; pfam03230 439855009865 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 439855009866 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 439855009867 MPN+ (JAMM) motif; other site 439855009868 Zinc-binding site [ion binding]; other site 439855009869 Protein of unknown function (DUF987); Region: DUF987; pfam06174 439855009870 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 439855009871 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 439855009872 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 439855009873 Methyltransferase domain; Region: Methyltransf_27; pfam13708 439855009874 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 439855009875 KpsF/GutQ family protein; Region: kpsF; TIGR00393 439855009876 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 439855009877 putative active site [active] 439855009878 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 439855009879 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 439855009880 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 439855009881 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 439855009882 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 439855009883 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 439855009884 Ligand binding site; other site 439855009885 oligomer interface; other site 439855009886 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 439855009887 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 439855009888 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 439855009889 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 439855009890 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 439855009891 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 439855009892 active site 439855009893 homodimer interface [polypeptide binding]; other site 439855009894 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 439855009895 ligand binding site; other site 439855009896 tetramer interface; other site 439855009897 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 439855009898 active site 439855009899 catalytic triad [active] 439855009900 oxyanion hole [active] 439855009901 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 439855009902 NeuB family; Region: NeuB; pfam03102 439855009903 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 439855009904 NeuB binding interface [polypeptide binding]; other site 439855009905 putative substrate binding site [chemical binding]; other site 439855009906 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 439855009907 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 439855009908 putative trimer interface [polypeptide binding]; other site 439855009909 putative CoA binding site [chemical binding]; other site 439855009910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 439855009911 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 439855009912 Walker A/P-loop; other site 439855009913 ATP binding site [chemical binding]; other site 439855009914 Q-loop/lid; other site 439855009915 ABC transporter signature motif; other site 439855009916 Walker B; other site 439855009917 D-loop; other site 439855009918 H-loop/switch region; other site 439855009919 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 439855009920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 439855009921 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 439855009922 Probable transposase; Region: OrfB_IS605; pfam01385 439855009923 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 439855009924 Transposase IS200 like; Region: Y1_Tnp; pfam01797 439855009925 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 439855009926 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 439855009927 GspL-like protein; Provisional; Region: PRK09662 439855009928 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 439855009929 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 439855009930 type II secretion system protein J; Region: gspJ; TIGR01711 439855009931 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 439855009932 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 439855009933 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 439855009934 Type II transport protein GspH; Region: GspH; pfam12019 439855009935 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 439855009936 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 439855009937 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 439855009938 type II secretion system protein F; Region: GspF; TIGR02120 439855009939 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 439855009940 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 439855009941 type II secretion system protein E; Region: type_II_gspE; TIGR02533 439855009942 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 439855009943 Walker A motif; other site 439855009944 ATP binding site [chemical binding]; other site 439855009945 Walker B motif; other site 439855009946 type II secretion system protein D; Region: type_II_gspD; TIGR02517 439855009947 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 439855009948 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 439855009949 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 439855009950 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 439855009951 putative type II secretion protein GspC; Provisional; Region: PRK09681 439855009952 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 439855009953 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 439855009954 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 439855009955 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 439855009956 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 439855009957 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 439855009958 Calcium-activated chloride channel; Region: Anoctamin; pfam04547 439855009959 Peptidase M60-like family; Region: M60-like; pfam13402 439855009960 glycolate transporter; Provisional; Region: PRK09695 439855009961 L-lactate permease; Region: Lactate_perm; cl00701 439855009962 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 439855009963 active site 439855009964 hypothetical protein; Provisional; Region: PRK09732 439855009965 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 439855009966 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 439855009967 Cysteine-rich domain; Region: CCG; pfam02754 439855009968 Cysteine-rich domain; Region: CCG; pfam02754 439855009969 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 439855009970 FAD binding domain; Region: FAD_binding_4; pfam01565 439855009971 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 439855009972 FAD binding domain; Region: FAD_binding_4; pfam01565 439855009973 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 439855009974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855009975 DNA-binding site [nucleotide binding]; DNA binding site 439855009976 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855009977 acyl-CoA synthetase; Validated; Region: PRK09192 439855009978 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 439855009979 acyl-activating enzyme (AAE) consensus motif; other site 439855009980 active site 439855009981 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 439855009982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 439855009983 NAD(P) binding site [chemical binding]; other site 439855009984 active site 439855009985 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 439855009986 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 439855009987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 439855009988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855009989 catalytic residue [active] 439855009990 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 439855009991 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 439855009992 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 439855009993 Predicted permeases [General function prediction only]; Region: COG0795 439855009994 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 439855009995 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 439855009996 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 439855009997 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 439855009998 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 439855009999 active site 439855010000 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 439855010001 TMP-binding site; other site 439855010002 ATP-binding site [chemical binding]; other site 439855010003 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 439855010004 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 439855010005 TMP-binding site; other site 439855010006 ATP-binding site [chemical binding]; other site 439855010007 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 439855010008 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 439855010009 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 439855010010 CHAP domain; Region: CHAP; pfam05257 439855010011 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 439855010012 putative S-transferase; Provisional; Region: PRK11752 439855010013 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 439855010014 C-terminal domain interface [polypeptide binding]; other site 439855010015 GSH binding site (G-site) [chemical binding]; other site 439855010016 dimer interface [polypeptide binding]; other site 439855010017 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 439855010018 dimer interface [polypeptide binding]; other site 439855010019 N-terminal domain interface [polypeptide binding]; other site 439855010020 active site 439855010021 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 439855010022 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 439855010023 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 439855010024 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 439855010025 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 439855010026 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 439855010027 putative substrate-binding site; other site 439855010028 nickel binding site [ion binding]; other site 439855010029 hydrogenase 2 large subunit; Provisional; Region: PRK10467 439855010030 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 439855010031 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 439855010032 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 439855010033 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 439855010034 4Fe-4S binding domain; Region: Fer4_6; pfam12837 439855010035 hydrogenase 2 small subunit; Provisional; Region: PRK10468 439855010036 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 439855010037 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 439855010038 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 439855010039 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 439855010040 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 439855010041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855010042 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855010043 active site 439855010044 catalytic tetrad [active] 439855010045 hypothetical protein; Provisional; Region: PRK05208 439855010046 oxidoreductase; Provisional; Region: PRK07985 439855010047 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 439855010048 NAD binding site [chemical binding]; other site 439855010049 metal binding site [ion binding]; metal-binding site 439855010050 active site 439855010051 biopolymer transport protein ExbD; Provisional; Region: PRK11267 439855010052 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 439855010053 biopolymer transport protein ExbB; Provisional; Region: PRK10414 439855010054 cystathionine beta-lyase; Provisional; Region: PRK08114 439855010055 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 439855010056 homodimer interface [polypeptide binding]; other site 439855010057 substrate-cofactor binding pocket; other site 439855010058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855010059 catalytic residue [active] 439855010060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 439855010061 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 439855010062 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 439855010063 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 439855010064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855010065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855010066 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 439855010067 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 439855010068 dimer interface [polypeptide binding]; other site 439855010069 active site 439855010070 metal binding site [ion binding]; metal-binding site 439855010071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 439855010072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 439855010073 active site 439855010074 catalytic tetrad [active] 439855010075 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 439855010076 putative outer membrane lipoprotein; Provisional; Region: PRK09973 439855010077 hypothetical protein; Provisional; Region: PRK01254 439855010078 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 439855010079 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 439855010080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 439855010081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855010082 DNA-binding site [nucleotide binding]; DNA binding site 439855010083 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855010084 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 439855010085 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 439855010086 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 439855010087 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855010088 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 439855010089 putative NAD(P) binding site [chemical binding]; other site 439855010090 catalytic Zn binding site [ion binding]; other site 439855010091 structural Zn binding site [ion binding]; other site 439855010092 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 439855010093 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 439855010094 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 439855010095 DctM-like transporters; Region: DctM; pfam06808 439855010096 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 439855010097 FtsI repressor; Provisional; Region: PRK10883 439855010098 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 439855010099 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 439855010100 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 439855010101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 439855010102 putative acyl-acceptor binding pocket; other site 439855010103 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 439855010104 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 439855010105 CAP-like domain; other site 439855010106 active site 439855010107 primary dimer interface [polypeptide binding]; other site 439855010108 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 439855010109 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 439855010110 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 439855010111 peptide binding site [polypeptide binding]; other site 439855010112 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 439855010113 TIGR00156 family protein; Region: TIGR00156 439855010114 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 439855010115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855010116 active site 439855010117 phosphorylation site [posttranslational modification] 439855010118 intermolecular recognition site; other site 439855010119 dimerization interface [polypeptide binding]; other site 439855010120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855010121 DNA binding site [nucleotide binding] 439855010122 sensor protein QseC; Provisional; Region: PRK10337 439855010123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855010124 dimer interface [polypeptide binding]; other site 439855010125 phosphorylation site [posttranslational modification] 439855010126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855010127 ATP binding site [chemical binding]; other site 439855010128 Mg2+ binding site [ion binding]; other site 439855010129 G-X-G motif; other site 439855010130 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 439855010131 Uncharacterized conserved protein [Function unknown]; Region: COG1359 439855010132 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 439855010133 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 439855010134 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 439855010135 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 439855010136 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 439855010137 siderophore binding site; other site 439855010138 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 439855010139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855010140 ABC-ATPase subunit interface; other site 439855010141 dimer interface [polypeptide binding]; other site 439855010142 putative PBP binding regions; other site 439855010143 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 439855010144 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855010145 dimer interface [polypeptide binding]; other site 439855010146 putative PBP binding regions; other site 439855010147 ABC-ATPase subunit interface; other site 439855010148 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 439855010149 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 439855010150 Walker A/P-loop; other site 439855010151 ATP binding site [chemical binding]; other site 439855010152 Q-loop/lid; other site 439855010153 ABC transporter signature motif; other site 439855010154 Walker B; other site 439855010155 D-loop; other site 439855010156 H-loop/switch region; other site 439855010157 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 439855010158 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855010159 N-terminal plug; other site 439855010160 ligand-binding site [chemical binding]; other site 439855010161 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 439855010162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855010163 ATP binding site [chemical binding]; other site 439855010164 Mg2+ binding site [ion binding]; other site 439855010165 G-X-G motif; other site 439855010166 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 439855010167 anchoring element; other site 439855010168 dimer interface [polypeptide binding]; other site 439855010169 ATP binding site [chemical binding]; other site 439855010170 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 439855010171 active site 439855010172 metal binding site [ion binding]; metal-binding site 439855010173 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 439855010174 esterase YqiA; Provisional; Region: PRK11071 439855010175 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 439855010176 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 439855010177 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 439855010178 active site 439855010179 metal binding site [ion binding]; metal-binding site 439855010180 hexamer interface [polypeptide binding]; other site 439855010181 putative dehydrogenase; Provisional; Region: PRK11039 439855010182 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 439855010183 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 439855010184 dimer interface [polypeptide binding]; other site 439855010185 ADP-ribose binding site [chemical binding]; other site 439855010186 active site 439855010187 nudix motif; other site 439855010188 metal binding site [ion binding]; metal-binding site 439855010189 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 439855010190 hypothetical protein; Provisional; Region: PRK11653 439855010191 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 439855010192 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 439855010193 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 439855010194 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 439855010195 catalytic residues [active] 439855010196 hinge region; other site 439855010197 alpha helical domain; other site 439855010198 putative disulfide oxidoreductase; Provisional; Region: PRK04307 439855010199 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 439855010200 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 439855010201 putative active site [active] 439855010202 metal binding site [ion binding]; metal-binding site 439855010203 zinc transporter ZupT; Provisional; Region: PRK04201 439855010204 ZIP Zinc transporter; Region: Zip; pfam02535 439855010205 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 439855010206 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 439855010207 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 439855010208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 439855010209 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 439855010210 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 439855010211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 439855010212 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 439855010213 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 439855010214 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 439855010215 putative ribose interaction site [chemical binding]; other site 439855010216 putative ADP binding site [chemical binding]; other site 439855010217 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 439855010218 active site 439855010219 nucleotide binding site [chemical binding]; other site 439855010220 HIGH motif; other site 439855010221 KMSKS motif; other site 439855010222 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 439855010223 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 439855010224 metal binding triad; other site 439855010225 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 439855010226 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 439855010227 metal binding triad; other site 439855010228 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 439855010229 Uncharacterized conserved protein [Function unknown]; Region: COG3025 439855010230 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 439855010231 putative active site [active] 439855010232 putative metal binding residues [ion binding]; other site 439855010233 signature motif; other site 439855010234 putative triphosphate binding site [ion binding]; other site 439855010235 CHAD domain; Region: CHAD; pfam05235 439855010236 SH3 domain-containing protein; Provisional; Region: PRK10884 439855010237 Bacterial SH3 domain homologues; Region: SH3b; smart00287 439855010238 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 439855010239 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 439855010240 active site 439855010241 NTP binding site [chemical binding]; other site 439855010242 metal binding triad [ion binding]; metal-binding site 439855010243 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 439855010244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855010245 Zn2+ binding site [ion binding]; other site 439855010246 Mg2+ binding site [ion binding]; other site 439855010247 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 439855010248 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 439855010249 homooctamer interface [polypeptide binding]; other site 439855010250 active site 439855010251 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 439855010252 transcriptional activator TtdR; Provisional; Region: PRK09801 439855010253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855010254 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 439855010255 putative effector binding pocket; other site 439855010256 putative dimerization interface [polypeptide binding]; other site 439855010257 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 439855010258 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 439855010259 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 439855010260 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 439855010261 transmembrane helices; other site 439855010262 UGMP family protein; Validated; Region: PRK09604 439855010263 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 439855010264 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 439855010265 DNA primase; Validated; Region: dnaG; PRK05667 439855010266 CHC2 zinc finger; Region: zf-CHC2; pfam01807 439855010267 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 439855010268 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 439855010269 active site 439855010270 metal binding site [ion binding]; metal-binding site 439855010271 interdomain interaction site; other site 439855010272 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 439855010273 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 439855010274 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 439855010275 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 439855010276 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 439855010277 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 439855010278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 439855010279 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 439855010280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855010281 DNA binding residues [nucleotide binding] 439855010282 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 439855010283 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 439855010284 active site 439855010285 SUMO-1 interface [polypeptide binding]; other site 439855010286 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 439855010287 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 439855010288 FAD binding pocket [chemical binding]; other site 439855010289 FAD binding motif [chemical binding]; other site 439855010290 phosphate binding motif [ion binding]; other site 439855010291 NAD binding pocket [chemical binding]; other site 439855010292 Predicted transcriptional regulators [Transcription]; Region: COG1695 439855010293 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 439855010294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855010295 PAS fold; Region: PAS_3; pfam08447 439855010296 putative active site [active] 439855010297 heme pocket [chemical binding]; other site 439855010298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 439855010299 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 439855010300 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 439855010301 dimer interface [polypeptide binding]; other site 439855010302 putative CheW interface [polypeptide binding]; other site 439855010303 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 439855010304 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855010305 inhibitor-cofactor binding pocket; inhibition site 439855010306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855010307 catalytic residue [active] 439855010308 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 439855010309 dimer interface [polypeptide binding]; other site 439855010310 putative tRNA-binding site [nucleotide binding]; other site 439855010311 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 439855010312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855010313 DNA binding site [nucleotide binding] 439855010314 domain linker motif; other site 439855010315 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 439855010316 putative dimerization interface [polypeptide binding]; other site 439855010317 putative ligand binding site [chemical binding]; other site 439855010318 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 439855010319 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 439855010320 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 439855010321 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 439855010322 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 439855010323 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 439855010324 inner membrane transporter YjeM; Provisional; Region: PRK15238 439855010325 alpha-glucosidase; Provisional; Region: PRK10137 439855010326 Protein of unknown function, DUF608; Region: DUF608; pfam04685 439855010327 Trehalase; Region: Trehalase; cl17346 439855010328 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 439855010329 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 439855010330 active site 439855010331 FMN binding site [chemical binding]; other site 439855010332 2,4-decadienoyl-CoA binding site; other site 439855010333 catalytic residue [active] 439855010334 4Fe-4S cluster binding site [ion binding]; other site 439855010335 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 439855010336 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 439855010337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855010338 S-adenosylmethionine binding site [chemical binding]; other site 439855010339 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 439855010340 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 439855010341 putative active site [active] 439855010342 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 439855010343 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 439855010344 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 439855010345 serine/threonine transporter SstT; Provisional; Region: PRK13628 439855010346 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 439855010347 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 439855010348 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 439855010349 galactarate dehydratase; Region: galactar-dH20; TIGR03248 439855010350 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 439855010351 Glucuronate isomerase; Region: UxaC; pfam02614 439855010352 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 439855010353 D-galactonate transporter; Region: 2A0114; TIGR00893 439855010354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855010355 putative substrate translocation pore; other site 439855010356 CblD like pilus biogenesis initiator; Region: CblD; cl06460 439855010357 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 439855010358 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855010359 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 439855010360 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 439855010361 putative fimbrial protein TcfA; Provisional; Region: PRK15308 439855010362 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 439855010363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855010364 DNA-binding site [nucleotide binding]; DNA binding site 439855010365 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855010366 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 439855010367 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 439855010368 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 439855010369 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 439855010370 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 439855010371 Predicted membrane protein [Function unknown]; Region: COG5393 439855010372 YqjK-like protein; Region: YqjK; pfam13997 439855010373 Predicted membrane protein [Function unknown]; Region: COG2259 439855010374 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 439855010375 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 439855010376 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 439855010377 putative dimer interface [polypeptide binding]; other site 439855010378 N-terminal domain interface [polypeptide binding]; other site 439855010379 putative substrate binding pocket (H-site) [chemical binding]; other site 439855010380 Predicted membrane protein [Function unknown]; Region: COG3152 439855010381 Protein of unknown function (DUF805); Region: DUF805; pfam05656 439855010382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855010383 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 439855010384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855010385 dimerization interface [polypeptide binding]; other site 439855010386 Pirin-related protein [General function prediction only]; Region: COG1741 439855010387 Pirin; Region: Pirin; pfam02678 439855010388 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 439855010389 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 439855010390 serine transporter; Region: stp; TIGR00814 439855010391 L-serine dehydratase TdcG; Provisional; Region: PRK15040 439855010392 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 439855010393 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 439855010394 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 439855010395 homotrimer interaction site [polypeptide binding]; other site 439855010396 putative active site [active] 439855010397 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 439855010398 Pyruvate formate lyase 1; Region: PFL1; cd01678 439855010399 coenzyme A binding site [chemical binding]; other site 439855010400 active site 439855010401 catalytic residues [active] 439855010402 glycine loop; other site 439855010403 propionate/acetate kinase; Provisional; Region: PRK12379 439855010404 Acetokinase family; Region: Acetate_kinase; cl17229 439855010405 threonine/serine transporter TdcC; Provisional; Region: PRK13629 439855010406 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 439855010407 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 439855010408 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 439855010409 tetramer interface [polypeptide binding]; other site 439855010410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855010411 catalytic residue [active] 439855010412 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 439855010413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855010414 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 439855010415 putative substrate binding pocket [chemical binding]; other site 439855010416 putative dimerization interface [polypeptide binding]; other site 439855010417 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 439855010418 hypothetical protein; Provisional; Region: PRK09716 439855010419 glycerate kinase I; Provisional; Region: PRK10342 439855010420 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 439855010421 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 439855010422 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 439855010423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855010424 D-galactonate transporter; Region: 2A0114; TIGR00893 439855010425 putative substrate translocation pore; other site 439855010426 galactarate dehydratase; Region: galactar-dH20; TIGR03248 439855010427 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 439855010428 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 439855010429 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 439855010430 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 439855010431 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 439855010432 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 439855010433 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855010434 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 439855010435 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 439855010436 active site 439855010437 phosphorylation site [posttranslational modification] 439855010438 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 439855010439 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 439855010440 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 439855010441 active pocket/dimerization site; other site 439855010442 active site 439855010443 phosphorylation site [posttranslational modification] 439855010444 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 439855010445 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 439855010446 active site 439855010447 dimer interface [polypeptide binding]; other site 439855010448 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 439855010449 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 439855010450 dimer interface [polypeptide binding]; other site 439855010451 active site 439855010452 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 439855010453 putative active site [active] 439855010454 tagatose-bisphosphate aldolase; Reviewed; Region: kbaY; PRK12738 439855010455 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 439855010456 active site 439855010457 intersubunit interface [polypeptide binding]; other site 439855010458 zinc binding site [ion binding]; other site 439855010459 Na+ binding site [ion binding]; other site 439855010460 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 439855010461 active site 439855010462 phosphorylation site [posttranslational modification] 439855010463 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 439855010464 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 439855010465 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 439855010466 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 439855010467 active site 439855010468 trimer interface [polypeptide binding]; other site 439855010469 allosteric site; other site 439855010470 active site lid [active] 439855010471 hexamer (dimer of trimers) interface [polypeptide binding]; other site 439855010472 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 439855010473 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 439855010474 putative SAM binding site [chemical binding]; other site 439855010475 putative homodimer interface [polypeptide binding]; other site 439855010476 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 439855010477 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 439855010478 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 439855010479 putative ligand binding site [chemical binding]; other site 439855010480 TIGR00252 family protein; Region: TIGR00252 439855010481 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 439855010482 dimer interface [polypeptide binding]; other site 439855010483 active site 439855010484 outer membrane lipoprotein; Provisional; Region: PRK11023 439855010485 BON domain; Region: BON; pfam04972 439855010486 BON domain; Region: BON; pfam04972 439855010487 Predicted permease; Region: DUF318; pfam03773 439855010488 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 439855010489 NADH(P)-binding; Region: NAD_binding_10; pfam13460 439855010490 NAD binding site [chemical binding]; other site 439855010491 active site 439855010492 intracellular protease, PfpI family; Region: PfpI; TIGR01382 439855010493 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 439855010494 proposed catalytic triad [active] 439855010495 conserved cys residue [active] 439855010496 hypothetical protein; Provisional; Region: PRK03467 439855010497 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 439855010498 GIY-YIG motif/motif A; other site 439855010499 putative active site [active] 439855010500 putative metal binding site [ion binding]; other site 439855010501 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 439855010502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855010503 Coenzyme A binding pocket [chemical binding]; other site 439855010504 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 439855010505 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 439855010506 Peptidase family U32; Region: Peptidase_U32; pfam01136 439855010507 putative protease; Provisional; Region: PRK15447 439855010508 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 439855010509 hypothetical protein; Provisional; Region: PRK10508 439855010510 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 439855010511 tryptophan permease; Provisional; Region: PRK10483 439855010512 aromatic amino acid transport protein; Region: araaP; TIGR00837 439855010513 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 439855010514 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 439855010515 ATP binding site [chemical binding]; other site 439855010516 Mg++ binding site [ion binding]; other site 439855010517 motif III; other site 439855010518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855010519 nucleotide binding region [chemical binding]; other site 439855010520 ATP-binding site [chemical binding]; other site 439855010521 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 439855010522 putative RNA binding site [nucleotide binding]; other site 439855010523 lipoprotein NlpI; Provisional; Region: PRK11189 439855010524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855010525 binding surface 439855010526 TPR motif; other site 439855010527 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 439855010528 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 439855010529 RNase E interface [polypeptide binding]; other site 439855010530 trimer interface [polypeptide binding]; other site 439855010531 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 439855010532 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 439855010533 RNase E interface [polypeptide binding]; other site 439855010534 trimer interface [polypeptide binding]; other site 439855010535 active site 439855010536 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 439855010537 putative nucleic acid binding region [nucleotide binding]; other site 439855010538 G-X-X-G motif; other site 439855010539 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 439855010540 RNA binding site [nucleotide binding]; other site 439855010541 domain interface; other site 439855010542 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 439855010543 16S/18S rRNA binding site [nucleotide binding]; other site 439855010544 S13e-L30e interaction site [polypeptide binding]; other site 439855010545 25S rRNA binding site [nucleotide binding]; other site 439855010546 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 439855010547 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 439855010548 RNA binding site [nucleotide binding]; other site 439855010549 active site 439855010550 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 439855010551 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 439855010552 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 439855010553 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 439855010554 translation initiation factor IF-2; Region: IF-2; TIGR00487 439855010555 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 439855010556 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 439855010557 G1 box; other site 439855010558 putative GEF interaction site [polypeptide binding]; other site 439855010559 GTP/Mg2+ binding site [chemical binding]; other site 439855010560 Switch I region; other site 439855010561 G2 box; other site 439855010562 G3 box; other site 439855010563 Switch II region; other site 439855010564 G4 box; other site 439855010565 G5 box; other site 439855010566 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 439855010567 Translation-initiation factor 2; Region: IF-2; pfam11987 439855010568 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 439855010569 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 439855010570 NusA N-terminal domain; Region: NusA_N; pfam08529 439855010571 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 439855010572 RNA binding site [nucleotide binding]; other site 439855010573 homodimer interface [polypeptide binding]; other site 439855010574 NusA-like KH domain; Region: KH_5; pfam13184 439855010575 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 439855010576 G-X-X-G motif; other site 439855010577 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 439855010578 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 439855010579 ribosome maturation protein RimP; Reviewed; Region: PRK00092 439855010580 Sm and related proteins; Region: Sm_like; cl00259 439855010581 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 439855010582 putative oligomer interface [polypeptide binding]; other site 439855010583 putative RNA binding site [nucleotide binding]; other site 439855010584 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 439855010585 ANP binding site [chemical binding]; other site 439855010586 Substrate Binding Site II [chemical binding]; other site 439855010587 Substrate Binding Site I [chemical binding]; other site 439855010588 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 439855010589 Sulfatase; Region: Sulfatase; pfam00884 439855010590 Preprotein translocase SecG subunit; Region: SecG; pfam03840 439855010591 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 439855010592 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 439855010593 active site 439855010594 substrate binding site [chemical binding]; other site 439855010595 metal binding site [ion binding]; metal-binding site 439855010596 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 439855010597 dihydropteroate synthase; Region: DHPS; TIGR01496 439855010598 substrate binding pocket [chemical binding]; other site 439855010599 dimer interface [polypeptide binding]; other site 439855010600 inhibitor binding site; inhibition site 439855010601 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 439855010602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855010603 Walker A motif; other site 439855010604 ATP binding site [chemical binding]; other site 439855010605 Walker B motif; other site 439855010606 arginine finger; other site 439855010607 Peptidase family M41; Region: Peptidase_M41; pfam01434 439855010608 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 439855010609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855010610 S-adenosylmethionine binding site [chemical binding]; other site 439855010611 RNA-binding protein YhbY; Provisional; Region: PRK10343 439855010612 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 439855010613 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 439855010614 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 439855010615 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 439855010616 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 439855010617 GTPase CgtA; Reviewed; Region: obgE; PRK12298 439855010618 GTP1/OBG; Region: GTP1_OBG; pfam01018 439855010619 Obg GTPase; Region: Obg; cd01898 439855010620 G1 box; other site 439855010621 GTP/Mg2+ binding site [chemical binding]; other site 439855010622 Switch I region; other site 439855010623 G2 box; other site 439855010624 G3 box; other site 439855010625 Switch II region; other site 439855010626 G4 box; other site 439855010627 G5 box; other site 439855010628 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 439855010629 EamA-like transporter family; Region: EamA; pfam00892 439855010630 EamA-like transporter family; Region: EamA; pfam00892 439855010631 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 439855010632 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 439855010633 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 439855010634 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 439855010635 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 439855010636 substrate binding pocket [chemical binding]; other site 439855010637 chain length determination region; other site 439855010638 substrate-Mg2+ binding site; other site 439855010639 catalytic residues [active] 439855010640 aspartate-rich region 1; other site 439855010641 active site lid residues [active] 439855010642 aspartate-rich region 2; other site 439855010643 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 439855010644 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 439855010645 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 439855010646 hinge; other site 439855010647 active site 439855010648 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 439855010649 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 439855010650 anti sigma factor interaction site; other site 439855010651 regulatory phosphorylation site [posttranslational modification]; other site 439855010652 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 439855010653 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 439855010654 mce related protein; Region: MCE; pfam02470 439855010655 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 439855010656 conserved hypothetical integral membrane protein; Region: TIGR00056 439855010657 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 439855010658 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 439855010659 Walker A/P-loop; other site 439855010660 ATP binding site [chemical binding]; other site 439855010661 Q-loop/lid; other site 439855010662 ABC transporter signature motif; other site 439855010663 Walker B; other site 439855010664 D-loop; other site 439855010665 H-loop/switch region; other site 439855010666 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 439855010667 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 439855010668 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 439855010669 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 439855010670 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 439855010671 putative active site [active] 439855010672 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 439855010673 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 439855010674 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 439855010675 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 439855010676 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 439855010677 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 439855010678 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 439855010679 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 439855010680 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 439855010681 Walker A/P-loop; other site 439855010682 ATP binding site [chemical binding]; other site 439855010683 Q-loop/lid; other site 439855010684 ABC transporter signature motif; other site 439855010685 Walker B; other site 439855010686 D-loop; other site 439855010687 H-loop/switch region; other site 439855010688 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 439855010689 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 439855010690 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 439855010691 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 439855010692 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 439855010693 30S subunit binding site; other site 439855010694 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855010695 active site 439855010696 phosphorylation site [posttranslational modification] 439855010697 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 439855010698 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855010699 dimerization domain swap beta strand [polypeptide binding]; other site 439855010700 regulatory protein interface [polypeptide binding]; other site 439855010701 active site 439855010702 regulatory phosphorylation site [posttranslational modification]; other site 439855010703 hypothetical protein; Provisional; Region: PRK10345 439855010704 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 439855010705 Transglycosylase; Region: Transgly; cl17702 439855010706 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 439855010707 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 439855010708 conserved cys residue [active] 439855010709 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 439855010710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855010711 putative active site [active] 439855010712 heme pocket [chemical binding]; other site 439855010713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855010714 dimer interface [polypeptide binding]; other site 439855010715 phosphorylation site [posttranslational modification] 439855010716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855010717 ATP binding site [chemical binding]; other site 439855010718 Mg2+ binding site [ion binding]; other site 439855010719 G-X-G motif; other site 439855010720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855010721 active site 439855010722 phosphorylation site [posttranslational modification] 439855010723 intermolecular recognition site; other site 439855010724 dimerization interface [polypeptide binding]; other site 439855010725 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 439855010726 putative binding surface; other site 439855010727 active site 439855010728 radical SAM protein, TIGR01212 family; Region: TIGR01212 439855010729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855010730 FeS/SAM binding site; other site 439855010731 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 439855010732 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 439855010733 active site 439855010734 dimer interface [polypeptide binding]; other site 439855010735 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 439855010736 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 439855010737 active site 439855010738 FMN binding site [chemical binding]; other site 439855010739 substrate binding site [chemical binding]; other site 439855010740 3Fe-4S cluster binding site [ion binding]; other site 439855010741 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 439855010742 domain interface; other site 439855010743 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 439855010744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855010745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855010746 SWIM zinc finger; Region: SWIM; pfam04434 439855010747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855010748 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 439855010749 Walker A motif; other site 439855010750 ATP binding site [chemical binding]; other site 439855010751 Walker B motif; other site 439855010752 arginine finger; other site 439855010753 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 439855010754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 439855010755 metal ion-dependent adhesion site (MIDAS); other site 439855010756 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 439855010757 N-acetylmannosamine kinase; Provisional; Region: PRK05082 439855010758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855010759 nucleotide binding site [chemical binding]; other site 439855010760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 439855010761 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 439855010762 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 439855010763 putative active site cavity [active] 439855010764 putative sialic acid transporter; Provisional; Region: PRK03893 439855010765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855010766 putative substrate translocation pore; other site 439855010767 N-acetylneuraminate lyase; Region: nanA; TIGR00683 439855010768 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 439855010769 inhibitor site; inhibition site 439855010770 active site 439855010771 dimer interface [polypeptide binding]; other site 439855010772 catalytic residue [active] 439855010773 transcriptional regulator NanR; Provisional; Region: PRK03837 439855010774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855010775 DNA-binding site [nucleotide binding]; DNA binding site 439855010776 FCD domain; Region: FCD; pfam07729 439855010777 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 439855010778 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 439855010779 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 439855010780 stringent starvation protein A; Provisional; Region: sspA; PRK09481 439855010781 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 439855010782 C-terminal domain interface [polypeptide binding]; other site 439855010783 putative GSH binding site (G-site) [chemical binding]; other site 439855010784 dimer interface [polypeptide binding]; other site 439855010785 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 439855010786 dimer interface [polypeptide binding]; other site 439855010787 N-terminal domain interface [polypeptide binding]; other site 439855010788 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 439855010789 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 439855010790 23S rRNA interface [nucleotide binding]; other site 439855010791 L3 interface [polypeptide binding]; other site 439855010792 Predicted ATPase [General function prediction only]; Region: COG1485 439855010793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 439855010794 hypothetical protein; Provisional; Region: PRK11677 439855010795 serine endoprotease; Provisional; Region: PRK10139 439855010796 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 439855010797 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 439855010798 protein binding site [polypeptide binding]; other site 439855010799 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 439855010800 serine endoprotease; Provisional; Region: PRK10898 439855010801 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 439855010802 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 439855010803 malate dehydrogenase; Provisional; Region: PRK05086 439855010804 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 439855010805 NAD binding site [chemical binding]; other site 439855010806 dimerization interface [polypeptide binding]; other site 439855010807 Substrate binding site [chemical binding]; other site 439855010808 arginine repressor; Provisional; Region: PRK05066 439855010809 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 439855010810 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 439855010811 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855010812 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 439855010813 RNAase interaction site [polypeptide binding]; other site 439855010814 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 439855010815 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 439855010816 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 439855010817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855010818 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855010819 efflux system membrane protein; Provisional; Region: PRK11594 439855010820 transcriptional regulator; Provisional; Region: PRK10632 439855010821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855010822 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 439855010823 putative effector binding pocket; other site 439855010824 dimerization interface [polypeptide binding]; other site 439855010825 protease TldD; Provisional; Region: tldD; PRK10735 439855010826 hypothetical protein; Provisional; Region: PRK10899 439855010827 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 439855010828 ribonuclease G; Provisional; Region: PRK11712 439855010829 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 439855010830 homodimer interface [polypeptide binding]; other site 439855010831 oligonucleotide binding site [chemical binding]; other site 439855010832 Maf-like protein; Region: Maf; pfam02545 439855010833 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 439855010834 active site 439855010835 dimer interface [polypeptide binding]; other site 439855010836 rod shape-determining protein MreD; Provisional; Region: PRK11060 439855010837 rod shape-determining protein MreC; Region: mreC; TIGR00219 439855010838 rod shape-determining protein MreC; Region: MreC; pfam04085 439855010839 rod shape-determining protein MreB; Provisional; Region: PRK13927 439855010840 MreB and similar proteins; Region: MreB_like; cd10225 439855010841 nucleotide binding site [chemical binding]; other site 439855010842 Mg binding site [ion binding]; other site 439855010843 putative protofilament interaction site [polypeptide binding]; other site 439855010844 RodZ interaction site [polypeptide binding]; other site 439855010845 regulatory protein CsrD; Provisional; Region: PRK11059 439855010846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855010847 metal binding site [ion binding]; metal-binding site 439855010848 active site 439855010849 I-site; other site 439855010850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855010851 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 439855010852 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 439855010853 NADP binding site [chemical binding]; other site 439855010854 dimer interface [polypeptide binding]; other site 439855010855 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 439855010856 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 439855010857 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 439855010858 carboxyltransferase (CT) interaction site; other site 439855010859 biotinylation site [posttranslational modification]; other site 439855010860 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 439855010861 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 439855010862 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 439855010863 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 439855010864 hypothetical protein; Provisional; Region: PRK10633 439855010865 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 439855010866 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 439855010867 Na binding site [ion binding]; other site 439855010868 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 439855010869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 439855010870 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 439855010871 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 439855010872 FMN binding site [chemical binding]; other site 439855010873 active site 439855010874 catalytic residues [active] 439855010875 substrate binding site [chemical binding]; other site 439855010876 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 439855010877 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 439855010878 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 439855010879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855010880 DNA methylase; Region: N6_N4_Mtase; pfam01555 439855010881 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 439855010882 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 439855010883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855010884 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 439855010885 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 439855010886 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855010887 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855010888 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 439855010889 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 439855010890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855010891 substrate binding pocket [chemical binding]; other site 439855010892 membrane-bound complex binding site; other site 439855010893 hinge residues; other site 439855010894 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 439855010895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855010896 conserved gate region; other site 439855010897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855010898 dimer interface [polypeptide binding]; other site 439855010899 conserved gate region; other site 439855010900 putative PBP binding loops; other site 439855010901 ABC-ATPase subunit interface; other site 439855010902 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 439855010903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855010904 dimer interface [polypeptide binding]; other site 439855010905 conserved gate region; other site 439855010906 putative PBP binding loops; other site 439855010907 ABC-ATPase subunit interface; other site 439855010908 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 439855010909 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 439855010910 Walker A/P-loop; other site 439855010911 ATP binding site [chemical binding]; other site 439855010912 Q-loop/lid; other site 439855010913 ABC transporter signature motif; other site 439855010914 Walker B; other site 439855010915 D-loop; other site 439855010916 H-loop/switch region; other site 439855010917 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 439855010918 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 439855010919 trimer interface [polypeptide binding]; other site 439855010920 putative metal binding site [ion binding]; other site 439855010921 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 439855010922 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 439855010923 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 439855010924 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 439855010925 shikimate binding site; other site 439855010926 NAD(P) binding site [chemical binding]; other site 439855010927 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 439855010928 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 439855010929 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 439855010930 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 439855010931 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 439855010932 hypothetical protein; Validated; Region: PRK03430 439855010933 hypothetical protein; Provisional; Region: PRK10736 439855010934 DNA protecting protein DprA; Region: dprA; TIGR00732 439855010935 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 439855010936 active site 439855010937 catalytic residues [active] 439855010938 metal binding site [ion binding]; metal-binding site 439855010939 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 439855010940 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 439855010941 putative active site [active] 439855010942 substrate binding site [chemical binding]; other site 439855010943 putative cosubstrate binding site; other site 439855010944 catalytic site [active] 439855010945 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 439855010946 substrate binding site [chemical binding]; other site 439855010947 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 439855010948 putative RNA binding site [nucleotide binding]; other site 439855010949 16S rRNA methyltransferase B; Provisional; Region: PRK10901 439855010950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855010951 S-adenosylmethionine binding site [chemical binding]; other site 439855010952 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 439855010953 TrkA-N domain; Region: TrkA_N; pfam02254 439855010954 TrkA-C domain; Region: TrkA_C; pfam02080 439855010955 TrkA-N domain; Region: TrkA_N; pfam02254 439855010956 TrkA-C domain; Region: TrkA_C; pfam02080 439855010957 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 439855010958 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 439855010959 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 439855010960 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 439855010961 DNA binding residues [nucleotide binding] 439855010962 dimer interface [polypeptide binding]; other site 439855010963 metal binding site [ion binding]; metal-binding site 439855010964 hypothetical protein; Provisional; Region: PRK10203 439855010965 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 439855010966 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 439855010967 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 439855010968 alphaNTD homodimer interface [polypeptide binding]; other site 439855010969 alphaNTD - beta interaction site [polypeptide binding]; other site 439855010970 alphaNTD - beta' interaction site [polypeptide binding]; other site 439855010971 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 439855010972 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 439855010973 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 439855010974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855010975 RNA binding surface [nucleotide binding]; other site 439855010976 30S ribosomal protein S11; Validated; Region: PRK05309 439855010977 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 439855010978 30S ribosomal protein S13; Region: bact_S13; TIGR03631 439855010979 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 439855010980 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 439855010981 SecY translocase; Region: SecY; pfam00344 439855010982 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 439855010983 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 439855010984 23S rRNA binding site [nucleotide binding]; other site 439855010985 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 439855010986 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 439855010987 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 439855010988 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 439855010989 23S rRNA interface [nucleotide binding]; other site 439855010990 5S rRNA interface [nucleotide binding]; other site 439855010991 L27 interface [polypeptide binding]; other site 439855010992 L5 interface [polypeptide binding]; other site 439855010993 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 439855010994 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 439855010995 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 439855010996 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 439855010997 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 439855010998 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 439855010999 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 439855011000 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 439855011001 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 439855011002 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 439855011003 RNA binding site [nucleotide binding]; other site 439855011004 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 439855011005 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 439855011006 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 439855011007 23S rRNA interface [nucleotide binding]; other site 439855011008 putative translocon interaction site; other site 439855011009 signal recognition particle (SRP54) interaction site; other site 439855011010 L23 interface [polypeptide binding]; other site 439855011011 trigger factor interaction site; other site 439855011012 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 439855011013 23S rRNA interface [nucleotide binding]; other site 439855011014 5S rRNA interface [nucleotide binding]; other site 439855011015 putative antibiotic binding site [chemical binding]; other site 439855011016 L25 interface [polypeptide binding]; other site 439855011017 L27 interface [polypeptide binding]; other site 439855011018 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 439855011019 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 439855011020 G-X-X-G motif; other site 439855011021 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 439855011022 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 439855011023 protein-rRNA interface [nucleotide binding]; other site 439855011024 putative translocon binding site; other site 439855011025 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 439855011026 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 439855011027 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 439855011028 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 439855011029 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 439855011030 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 439855011031 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 439855011032 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 439855011033 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 439855011034 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 439855011035 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 439855011036 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 439855011037 heme binding site [chemical binding]; other site 439855011038 ferroxidase pore; other site 439855011039 ferroxidase diiron center [ion binding]; other site 439855011040 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 439855011041 elongation factor Tu; Reviewed; Region: PRK00049 439855011042 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 439855011043 G1 box; other site 439855011044 GEF interaction site [polypeptide binding]; other site 439855011045 GTP/Mg2+ binding site [chemical binding]; other site 439855011046 Switch I region; other site 439855011047 G2 box; other site 439855011048 G3 box; other site 439855011049 Switch II region; other site 439855011050 G4 box; other site 439855011051 G5 box; other site 439855011052 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 439855011053 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 439855011054 Antibiotic Binding Site [chemical binding]; other site 439855011055 elongation factor G; Reviewed; Region: PRK00007 439855011056 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 439855011057 G1 box; other site 439855011058 putative GEF interaction site [polypeptide binding]; other site 439855011059 GTP/Mg2+ binding site [chemical binding]; other site 439855011060 Switch I region; other site 439855011061 G2 box; other site 439855011062 G3 box; other site 439855011063 Switch II region; other site 439855011064 G4 box; other site 439855011065 G5 box; other site 439855011066 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 439855011067 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 439855011068 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 439855011069 30S ribosomal protein S7; Validated; Region: PRK05302 439855011070 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 439855011071 S17 interaction site [polypeptide binding]; other site 439855011072 S8 interaction site; other site 439855011073 16S rRNA interaction site [nucleotide binding]; other site 439855011074 streptomycin interaction site [chemical binding]; other site 439855011075 23S rRNA interaction site [nucleotide binding]; other site 439855011076 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 439855011077 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 439855011078 sulfur relay protein TusC; Validated; Region: PRK00211 439855011079 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 439855011080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 439855011081 YheO-like PAS domain; Region: PAS_6; pfam08348 439855011082 HTH domain; Region: HTH_22; pfam13309 439855011083 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 439855011084 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 439855011085 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 439855011086 phi X174 lysis protein; Provisional; Region: PRK02793 439855011087 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 439855011088 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 439855011089 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 439855011090 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 439855011091 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 439855011092 TrkA-N domain; Region: TrkA_N; pfam02254 439855011093 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 439855011094 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 439855011095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855011096 Walker A/P-loop; other site 439855011097 ATP binding site [chemical binding]; other site 439855011098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 439855011099 ABC transporter signature motif; other site 439855011100 Walker B; other site 439855011101 D-loop; other site 439855011102 ABC transporter; Region: ABC_tran_2; pfam12848 439855011103 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 439855011104 putative hydrolase; Provisional; Region: PRK10985 439855011105 hypothetical protein; Provisional; Region: PRK04966 439855011106 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 439855011107 active site 439855011108 hypothetical protein; Provisional; Region: PRK10738 439855011109 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 439855011110 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 439855011111 ligand binding site [chemical binding]; other site 439855011112 flexible hinge region; other site 439855011113 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 439855011114 putative switch regulator; other site 439855011115 non-specific DNA interactions [nucleotide binding]; other site 439855011116 DNA binding site [nucleotide binding] 439855011117 sequence specific DNA binding site [nucleotide binding]; other site 439855011118 putative cAMP binding site [chemical binding]; other site 439855011119 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 439855011120 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 439855011121 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 439855011122 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 439855011123 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 439855011124 inhibitor-cofactor binding pocket; inhibition site 439855011125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855011126 catalytic residue [active] 439855011127 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 439855011128 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 439855011129 glutamine binding [chemical binding]; other site 439855011130 catalytic triad [active] 439855011131 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 439855011132 cell filamentation protein Fic; Provisional; Region: PRK10347 439855011133 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 439855011134 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 439855011135 substrate binding site [chemical binding]; other site 439855011136 putative transporter; Provisional; Region: PRK03699 439855011137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855011138 putative substrate translocation pore; other site 439855011139 nitrite reductase subunit NirD; Provisional; Region: PRK14989 439855011140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855011141 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 439855011142 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 439855011143 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 439855011144 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 439855011145 nitrite transporter NirC; Provisional; Region: PRK11562 439855011146 siroheme synthase; Provisional; Region: cysG; PRK10637 439855011147 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 439855011148 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 439855011149 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 439855011150 active site 439855011151 SAM binding site [chemical binding]; other site 439855011152 homodimer interface [polypeptide binding]; other site 439855011153 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 439855011154 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 439855011155 Protein of unknown function; Region: YhfT; pfam10797 439855011156 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 439855011157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 439855011158 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 439855011159 active site 439855011160 substrate binding pocket [chemical binding]; other site 439855011161 homodimer interaction site [polypeptide binding]; other site 439855011162 putative mutase; Provisional; Region: PRK12383 439855011163 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 439855011164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 439855011165 dimer interface [polypeptide binding]; other site 439855011166 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 439855011167 active site 439855011168 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855011169 substrate binding site [chemical binding]; other site 439855011170 catalytic residue [active] 439855011171 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 439855011172 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 439855011173 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 439855011174 active site 439855011175 HIGH motif; other site 439855011176 dimer interface [polypeptide binding]; other site 439855011177 KMSKS motif; other site 439855011178 phosphoglycolate phosphatase; Provisional; Region: PRK13222 439855011179 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 439855011180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855011181 motif II; other site 439855011182 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 439855011183 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 439855011184 substrate binding site [chemical binding]; other site 439855011185 hexamer interface [polypeptide binding]; other site 439855011186 metal binding site [ion binding]; metal-binding site 439855011187 DNA adenine methylase; Provisional; Region: PRK10904 439855011188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 439855011189 cell division protein DamX; Validated; Region: PRK10905 439855011190 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 439855011191 active site 439855011192 dimer interface [polypeptide binding]; other site 439855011193 metal binding site [ion binding]; metal-binding site 439855011194 shikimate kinase; Reviewed; Region: aroK; PRK00131 439855011195 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 439855011196 ADP binding site [chemical binding]; other site 439855011197 magnesium binding site [ion binding]; other site 439855011198 putative shikimate binding site; other site 439855011199 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 439855011200 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 439855011201 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 439855011202 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 439855011203 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 439855011204 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 439855011205 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 439855011206 Transglycosylase; Region: Transgly; pfam00912 439855011207 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 439855011208 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 439855011209 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 439855011210 ADP-ribose binding site [chemical binding]; other site 439855011211 dimer interface [polypeptide binding]; other site 439855011212 active site 439855011213 nudix motif; other site 439855011214 metal binding site [ion binding]; metal-binding site 439855011215 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 439855011216 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 439855011217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855011218 motif II; other site 439855011219 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855011220 RNA binding surface [nucleotide binding]; other site 439855011221 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 439855011222 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 439855011223 dimerization interface [polypeptide binding]; other site 439855011224 domain crossover interface; other site 439855011225 redox-dependent activation switch; other site 439855011226 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 439855011227 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 439855011228 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 439855011229 active site 439855011230 substrate-binding site [chemical binding]; other site 439855011231 metal-binding site [ion binding] 439855011232 ATP binding site [chemical binding]; other site 439855011233 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 439855011234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855011235 non-specific DNA binding site [nucleotide binding]; other site 439855011236 salt bridge; other site 439855011237 sequence-specific DNA binding site [nucleotide binding]; other site 439855011238 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 439855011239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855011240 dimerization interface [polypeptide binding]; other site 439855011241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855011242 dimer interface [polypeptide binding]; other site 439855011243 phosphorylation site [posttranslational modification] 439855011244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855011245 ATP binding site [chemical binding]; other site 439855011246 G-X-G motif; other site 439855011247 osmolarity response regulator; Provisional; Region: ompR; PRK09468 439855011248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855011249 active site 439855011250 phosphorylation site [posttranslational modification] 439855011251 intermolecular recognition site; other site 439855011252 dimerization interface [polypeptide binding]; other site 439855011253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855011254 DNA binding site [nucleotide binding] 439855011255 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 439855011256 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 439855011257 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 439855011258 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 439855011259 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 439855011260 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 439855011261 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 439855011262 RNA binding site [nucleotide binding]; other site 439855011263 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 439855011264 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 439855011265 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 439855011266 G1 box; other site 439855011267 GTP/Mg2+ binding site [chemical binding]; other site 439855011268 Switch I region; other site 439855011269 G2 box; other site 439855011270 G3 box; other site 439855011271 Switch II region; other site 439855011272 G4 box; other site 439855011273 G5 box; other site 439855011274 Nucleoside recognition; Region: Gate; pfam07670 439855011275 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 439855011276 Nucleoside recognition; Region: Gate; pfam07670 439855011277 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 439855011278 putative transposase; Provisional; Region: PRK09857 439855011279 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 439855011280 carboxylesterase BioH; Provisional; Region: PRK10349 439855011281 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 439855011282 DNA utilization protein GntX; Provisional; Region: PRK11595 439855011283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855011284 active site 439855011285 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 439855011286 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 439855011287 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 439855011288 high-affinity gluconate transporter; Provisional; Region: PRK14984 439855011289 gluconate transporter; Region: gntP; TIGR00791 439855011290 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 439855011291 4-alpha-glucanotransferase; Region: malQ; TIGR00217 439855011292 maltodextrin phosphorylase; Provisional; Region: PRK14985 439855011293 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 439855011294 homodimer interface [polypeptide binding]; other site 439855011295 active site pocket [active] 439855011296 transcriptional regulator MalT; Provisional; Region: PRK04841 439855011297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855011298 DNA binding residues [nucleotide binding] 439855011299 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 439855011300 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 439855011301 putative active site [active] 439855011302 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 439855011303 hypothetical protein; Reviewed; Region: PRK09588 439855011304 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 439855011305 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 439855011306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855011307 Walker A motif; other site 439855011308 ATP binding site [chemical binding]; other site 439855011309 Walker B motif; other site 439855011310 arginine finger; other site 439855011311 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 439855011312 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 439855011313 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855011314 intramembrane serine protease GlpG; Provisional; Region: PRK10907 439855011315 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 439855011316 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 439855011317 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 439855011318 active site residue [active] 439855011319 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 439855011320 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 439855011321 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 439855011322 glycogen phosphorylase; Provisional; Region: PRK14986 439855011323 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 439855011324 homodimer interface [polypeptide binding]; other site 439855011325 active site pocket [active] 439855011326 glycogen synthase; Provisional; Region: glgA; PRK00654 439855011327 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 439855011328 ADP-binding pocket [chemical binding]; other site 439855011329 homodimer interface [polypeptide binding]; other site 439855011330 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 439855011331 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 439855011332 ligand binding site; other site 439855011333 oligomer interface; other site 439855011334 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 439855011335 sulfate 1 binding site; other site 439855011336 glycogen debranching enzyme; Provisional; Region: PRK03705 439855011337 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 439855011338 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 439855011339 active site 439855011340 catalytic site [active] 439855011341 glycogen branching enzyme; Provisional; Region: PRK05402 439855011342 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 439855011343 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 439855011344 active site 439855011345 catalytic site [active] 439855011346 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 439855011347 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 439855011348 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 439855011349 putative antibiotic transporter; Provisional; Region: PRK10739 439855011350 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 439855011351 DNA protecting protein DprA; Region: dprA; TIGR00732 439855011352 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 439855011353 non-specific DNA interactions [nucleotide binding]; other site 439855011354 DNA binding site [nucleotide binding] 439855011355 sequence specific DNA binding site [nucleotide binding]; other site 439855011356 putative cAMP binding site [chemical binding]; other site 439855011357 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 439855011358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855011359 ATP binding site [chemical binding]; other site 439855011360 putative Mg++ binding site [ion binding]; other site 439855011361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855011362 nucleotide binding region [chemical binding]; other site 439855011363 ATP-binding site [chemical binding]; other site 439855011364 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855011365 active site 439855011366 low affinity gluconate transporter; Provisional; Region: PRK10472 439855011367 gluconate transporter; Region: gntP; TIGR00791 439855011368 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 439855011369 ATP-binding site [chemical binding]; other site 439855011370 Gluconate-6-phosphate binding site [chemical binding]; other site 439855011371 Shikimate kinase; Region: SKI; pfam01202 439855011372 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 439855011373 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855011374 DNA binding site [nucleotide binding] 439855011375 domain linker motif; other site 439855011376 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 439855011377 putative ligand binding site [chemical binding]; other site 439855011378 putative dimerization interface [polypeptide binding]; other site 439855011379 Pirin-related protein [General function prediction only]; Region: COG1741 439855011380 Pirin; Region: Pirin; pfam02678 439855011381 putative oxidoreductase; Provisional; Region: PRK10206 439855011382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 439855011383 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 439855011384 putative acetyltransferase YhhY; Provisional; Region: PRK10140 439855011385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855011386 Coenzyme A binding pocket [chemical binding]; other site 439855011387 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 439855011388 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 439855011389 hypothetical protein; Provisional; Region: PRK10350 439855011390 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 439855011391 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 439855011392 putative active site [active] 439855011393 catalytic site [active] 439855011394 putative metal binding site [ion binding]; other site 439855011395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 439855011396 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 439855011397 Walker A/P-loop; other site 439855011398 ATP binding site [chemical binding]; other site 439855011399 Q-loop/lid; other site 439855011400 ABC transporter signature motif; other site 439855011401 Walker B; other site 439855011402 D-loop; other site 439855011403 H-loop/switch region; other site 439855011404 TOBE domain; Region: TOBE_2; pfam08402 439855011405 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 439855011406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855011407 dimer interface [polypeptide binding]; other site 439855011408 conserved gate region; other site 439855011409 putative PBP binding loops; other site 439855011410 ABC-ATPase subunit interface; other site 439855011411 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 439855011412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855011413 dimer interface [polypeptide binding]; other site 439855011414 conserved gate region; other site 439855011415 putative PBP binding loops; other site 439855011416 ABC-ATPase subunit interface; other site 439855011417 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 439855011418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 439855011419 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 439855011420 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 439855011421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 439855011422 binding surface 439855011423 TPR motif; other site 439855011424 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 439855011425 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 439855011426 Walker A/P-loop; other site 439855011427 ATP binding site [chemical binding]; other site 439855011428 Q-loop/lid; other site 439855011429 ABC transporter signature motif; other site 439855011430 Walker B; other site 439855011431 D-loop; other site 439855011432 H-loop/switch region; other site 439855011433 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 439855011434 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 439855011435 Walker A/P-loop; other site 439855011436 ATP binding site [chemical binding]; other site 439855011437 Q-loop/lid; other site 439855011438 ABC transporter signature motif; other site 439855011439 Walker B; other site 439855011440 D-loop; other site 439855011441 H-loop/switch region; other site 439855011442 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 439855011443 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 439855011444 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 439855011445 TM-ABC transporter signature motif; other site 439855011446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855011447 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 439855011448 TM-ABC transporter signature motif; other site 439855011449 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 439855011450 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 439855011451 dimerization interface [polypeptide binding]; other site 439855011452 ligand binding site [chemical binding]; other site 439855011453 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 439855011454 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 439855011455 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 439855011456 dimerization interface [polypeptide binding]; other site 439855011457 ligand binding site [chemical binding]; other site 439855011458 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 439855011459 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 439855011460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855011461 DNA binding residues [nucleotide binding] 439855011462 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 439855011463 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 439855011464 cell division protein FtsE; Provisional; Region: PRK10908 439855011465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855011466 Walker A/P-loop; other site 439855011467 ATP binding site [chemical binding]; other site 439855011468 Q-loop/lid; other site 439855011469 ABC transporter signature motif; other site 439855011470 Walker B; other site 439855011471 D-loop; other site 439855011472 H-loop/switch region; other site 439855011473 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 439855011474 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 439855011475 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 439855011476 P loop; other site 439855011477 GTP binding site [chemical binding]; other site 439855011478 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 439855011479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855011480 S-adenosylmethionine binding site [chemical binding]; other site 439855011481 hypothetical protein; Provisional; Region: PRK10910 439855011482 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 439855011483 Predicted membrane protein [Function unknown]; Region: COG3714 439855011484 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 439855011485 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 439855011486 metal-binding site [ion binding] 439855011487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 439855011488 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 439855011489 CPxP motif; other site 439855011490 hypothetical protein; Provisional; Region: PRK11212 439855011491 hypothetical protein; Provisional; Region: PRK11615 439855011492 major facilitator superfamily transporter; Provisional; Region: PRK05122 439855011493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855011494 putative substrate translocation pore; other site 439855011495 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 439855011496 Domain of unknown function DUF20; Region: UPF0118; pfam01594 439855011497 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 439855011498 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 439855011499 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 439855011500 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 439855011501 substrate binding site [chemical binding]; other site 439855011502 nickel transporter permease NikB; Provisional; Region: PRK10352 439855011503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855011504 dimer interface [polypeptide binding]; other site 439855011505 conserved gate region; other site 439855011506 putative PBP binding loops; other site 439855011507 ABC-ATPase subunit interface; other site 439855011508 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 439855011509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855011510 dimer interface [polypeptide binding]; other site 439855011511 conserved gate region; other site 439855011512 putative PBP binding loops; other site 439855011513 ABC-ATPase subunit interface; other site 439855011514 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 439855011515 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855011516 Walker A/P-loop; other site 439855011517 ATP binding site [chemical binding]; other site 439855011518 Q-loop/lid; other site 439855011519 ABC transporter signature motif; other site 439855011520 Walker B; other site 439855011521 D-loop; other site 439855011522 H-loop/switch region; other site 439855011523 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 439855011524 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 439855011525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855011526 Walker A/P-loop; other site 439855011527 ATP binding site [chemical binding]; other site 439855011528 Q-loop/lid; other site 439855011529 ABC transporter signature motif; other site 439855011530 Walker B; other site 439855011531 D-loop; other site 439855011532 H-loop/switch region; other site 439855011533 nickel responsive regulator; Provisional; Region: PRK02967 439855011534 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 439855011535 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 439855011536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855011537 DNA-binding site [nucleotide binding]; DNA binding site 439855011538 UTRA domain; Region: UTRA; pfam07702 439855011539 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855011540 active site 439855011541 phosphorylation site [posttranslational modification] 439855011542 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 439855011543 active site 439855011544 P-loop; other site 439855011545 phosphorylation site [posttranslational modification] 439855011546 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 439855011547 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 439855011548 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 439855011549 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 439855011550 putative N- and C-terminal domain interface [polypeptide binding]; other site 439855011551 putative active site [active] 439855011552 putative MgATP binding site [chemical binding]; other site 439855011553 catalytic site [active] 439855011554 metal binding site [ion binding]; metal-binding site 439855011555 putative carbohydrate binding site [chemical binding]; other site 439855011556 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855011557 dimerization domain swap beta strand [polypeptide binding]; other site 439855011558 regulatory protein interface [polypeptide binding]; other site 439855011559 active site 439855011560 regulatory phosphorylation site [posttranslational modification]; other site 439855011561 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 439855011562 intersubunit interface [polypeptide binding]; other site 439855011563 active site 439855011564 zinc binding site [ion binding]; other site 439855011565 Na+ binding site [ion binding]; other site 439855011566 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 439855011567 HicB family; Region: HicB; pfam05534 439855011568 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 439855011569 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 439855011570 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 439855011571 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 439855011572 Walker A/P-loop; other site 439855011573 ATP binding site [chemical binding]; other site 439855011574 Q-loop/lid; other site 439855011575 ABC transporter signature motif; other site 439855011576 Walker B; other site 439855011577 D-loop; other site 439855011578 H-loop/switch region; other site 439855011579 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 439855011580 Walker A/P-loop; other site 439855011581 ATP binding site [chemical binding]; other site 439855011582 Q-loop/lid; other site 439855011583 ABC transporter signature motif; other site 439855011584 Walker B; other site 439855011585 D-loop; other site 439855011586 H-loop/switch region; other site 439855011587 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 439855011588 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 439855011589 HlyD family secretion protein; Region: HlyD; pfam00529 439855011590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855011591 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855011592 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 439855011593 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 439855011594 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 439855011595 Predicted flavoproteins [General function prediction only]; Region: COG2081 439855011596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855011597 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 439855011598 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 439855011599 universal stress protein UspB; Provisional; Region: PRK04960 439855011600 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855011601 Ligand Binding Site [chemical binding]; other site 439855011602 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 439855011603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855011604 POT family; Region: PTR2; pfam00854 439855011605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855011606 S-adenosylmethionine binding site [chemical binding]; other site 439855011607 oligopeptidase A; Provisional; Region: PRK10911 439855011608 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 439855011609 active site 439855011610 Zn binding site [ion binding]; other site 439855011611 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 439855011612 glutathione reductase; Validated; Region: PRK06116 439855011613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855011614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855011615 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 439855011616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855011617 dimerization interface [polypeptide binding]; other site 439855011618 putative DNA binding site [nucleotide binding]; other site 439855011619 putative Zn2+ binding site [ion binding]; other site 439855011620 arsenical pump membrane protein; Provisional; Region: PRK15445 439855011621 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 439855011622 transmembrane helices; other site 439855011623 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 439855011624 ArsC family; Region: ArsC; pfam03960 439855011625 catalytic residues [active] 439855011626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855011627 dimerization interface [polypeptide binding]; other site 439855011628 putative DNA binding site [nucleotide binding]; other site 439855011629 putative Zn2+ binding site [ion binding]; other site 439855011630 Predicted permeases [General function prediction only]; Region: COG0701 439855011631 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 439855011632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 439855011633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855011634 DNA binding residues [nucleotide binding] 439855011635 dimerization interface [polypeptide binding]; other site 439855011636 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 439855011637 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 439855011638 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 439855011639 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 439855011640 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855011641 N-terminal plug; other site 439855011642 ligand-binding site [chemical binding]; other site 439855011643 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 439855011644 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 439855011645 putative hemin binding site; other site 439855011646 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 439855011647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855011648 FeS/SAM binding site; other site 439855011649 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 439855011650 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 439855011651 NADH(P)-binding; Region: NAD_binding_10; pfam13460 439855011652 NAD(P) binding site [chemical binding]; other site 439855011653 putative active site [active] 439855011654 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 439855011655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 439855011656 ABC-ATPase subunit interface; other site 439855011657 dimer interface [polypeptide binding]; other site 439855011658 putative PBP binding regions; other site 439855011659 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 439855011660 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 439855011661 Walker A/P-loop; other site 439855011662 ATP binding site [chemical binding]; other site 439855011663 Q-loop/lid; other site 439855011664 ABC transporter signature motif; other site 439855011665 Walker B; other site 439855011666 D-loop; other site 439855011667 H-loop/switch region; other site 439855011668 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 439855011669 MgtC family; Region: MgtC; pfam02308 439855011670 acid-resistance protein; Provisional; Region: hdeB; PRK11566 439855011671 acid-resistance protein; Provisional; Region: PRK10208 439855011672 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 439855011673 acid-resistance membrane protein; Provisional; Region: PRK10209 439855011674 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 439855011675 pyruvate kinase; Provisional; Region: PRK05826 439855011676 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 439855011677 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855011678 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855011679 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 439855011680 Protein export membrane protein; Region: SecD_SecF; cl14618 439855011681 transcriptional regulator YdeO; Provisional; Region: PRK09940 439855011682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855011683 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 439855011684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855011685 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 439855011686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855011687 catalytic residue [active] 439855011688 Haem-binding domain; Region: Haem_bd; pfam14376 439855011689 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 439855011690 trehalase; Provisional; Region: treF; PRK13270 439855011691 Trehalase; Region: Trehalase; pfam01204 439855011692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 439855011693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855011694 DNA binding residues [nucleotide binding] 439855011695 dimerization interface [polypeptide binding]; other site 439855011696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855011697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855011698 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 439855011699 putative effector binding pocket; other site 439855011700 putative dimerization interface [polypeptide binding]; other site 439855011701 inner membrane protein YhjD; Region: TIGR00766 439855011702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855011703 metabolite-proton symporter; Region: 2A0106; TIGR00883 439855011704 putative substrate translocation pore; other site 439855011705 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 439855011706 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 439855011707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855011708 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855011709 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 439855011710 substrate binding site [chemical binding]; other site 439855011711 ATP binding site [chemical binding]; other site 439855011712 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 439855011713 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 439855011714 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 439855011715 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 439855011716 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 439855011717 putative diguanylate cyclase; Provisional; Region: PRK13561 439855011718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 439855011719 metal binding site [ion binding]; metal-binding site 439855011720 active site 439855011721 I-site; other site 439855011722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855011723 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 439855011724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855011725 binding surface 439855011726 TPR motif; other site 439855011727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855011728 binding surface 439855011729 TPR motif; other site 439855011730 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 439855011731 endo-1,4-D-glucanase; Provisional; Region: PRK11097 439855011732 cellulose synthase regulator protein; Provisional; Region: PRK11114 439855011733 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 439855011734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 439855011735 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 439855011736 DXD motif; other site 439855011737 PilZ domain; Region: PilZ; pfam07238 439855011738 cell division protein; Provisional; Region: PRK10037 439855011739 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 439855011740 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 439855011741 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 439855011742 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 439855011743 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 439855011744 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855011745 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855011746 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855011747 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855011748 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 439855011749 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 439855011750 serine transporter; Region: stp; TIGR00814 439855011751 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 439855011752 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855011753 Walker A/P-loop; other site 439855011754 ATP binding site [chemical binding]; other site 439855011755 Q-loop/lid; other site 439855011756 ABC transporter signature motif; other site 439855011757 Walker B; other site 439855011758 D-loop; other site 439855011759 H-loop/switch region; other site 439855011760 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 439855011761 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 439855011762 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855011763 Walker A/P-loop; other site 439855011764 ATP binding site [chemical binding]; other site 439855011765 Q-loop/lid; other site 439855011766 ABC transporter signature motif; other site 439855011767 Walker B; other site 439855011768 D-loop; other site 439855011769 H-loop/switch region; other site 439855011770 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 439855011771 dipeptide transporter; Provisional; Region: PRK10913 439855011772 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 439855011773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855011774 dimer interface [polypeptide binding]; other site 439855011775 conserved gate region; other site 439855011776 putative PBP binding loops; other site 439855011777 ABC-ATPase subunit interface; other site 439855011778 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 439855011779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855011780 dimer interface [polypeptide binding]; other site 439855011781 conserved gate region; other site 439855011782 putative PBP binding loops; other site 439855011783 ABC-ATPase subunit interface; other site 439855011784 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 439855011785 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 439855011786 peptide binding site [polypeptide binding]; other site 439855011787 phosphoethanolamine transferase; Provisional; Region: PRK11560 439855011788 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 439855011789 Sulfatase; Region: Sulfatase; pfam00884 439855011790 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 439855011791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855011792 putative substrate translocation pore; other site 439855011793 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 439855011794 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 439855011795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 439855011796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855011797 Coenzyme A binding pocket [chemical binding]; other site 439855011798 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 439855011799 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 439855011800 molybdopterin cofactor binding site [chemical binding]; other site 439855011801 substrate binding site [chemical binding]; other site 439855011802 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 439855011803 molybdopterin cofactor binding site; other site 439855011804 putative outer membrane lipoprotein; Provisional; Region: PRK10510 439855011805 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855011806 ligand binding site [chemical binding]; other site 439855011807 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 439855011808 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 439855011809 dimerization interface [polypeptide binding]; other site 439855011810 ligand binding site [chemical binding]; other site 439855011811 NADP binding site [chemical binding]; other site 439855011812 catalytic site [active] 439855011813 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 439855011814 Predicted transcriptional regulator [Transcription]; Region: COG2944 439855011815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855011816 non-specific DNA binding site [nucleotide binding]; other site 439855011817 salt bridge; other site 439855011818 sequence-specific DNA binding site [nucleotide binding]; other site 439855011819 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 439855011820 DNA-binding site [nucleotide binding]; DNA binding site 439855011821 RNA-binding motif; other site 439855011822 small toxic polypeptide; Provisional; Region: PRK09759 439855011823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855011824 Helix-turn-helix domain; Region: HTH_28; pfam13518 439855011825 Helix-turn-helix domain; Region: HTH_28; pfam13518 439855011826 putative transposase OrfB; Reviewed; Region: PHA02517 439855011827 HTH-like domain; Region: HTH_21; pfam13276 439855011828 Integrase core domain; Region: rve; pfam00665 439855011829 Integrase core domain; Region: rve_2; pfam13333 439855011830 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 439855011831 DALR anticodon binding domain; Region: DALR_1; pfam05746 439855011832 anticodon binding site; other site 439855011833 tRNA binding surface [nucleotide binding]; other site 439855011834 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 439855011835 dimer interface [polypeptide binding]; other site 439855011836 motif 1; other site 439855011837 active site 439855011838 motif 2; other site 439855011839 motif 3; other site 439855011840 YsaB-like lipoprotein; Region: YsaB; pfam13983 439855011841 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 439855011842 Acyltransferase family; Region: Acyl_transf_3; pfam01757 439855011843 hypothetical protein; Provisional; Region: PRK11383 439855011844 yiaA/B two helix domain; Region: YiaAB; pfam05360 439855011845 yiaA/B two helix domain; Region: YiaAB; pfam05360 439855011846 hypothetical protein; Provisional; Region: PRK11403 439855011847 yiaA/B two helix domain; Region: YiaAB; pfam05360 439855011848 xylulokinase; Provisional; Region: PRK15027 439855011849 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 439855011850 N- and C-terminal domain interface [polypeptide binding]; other site 439855011851 active site 439855011852 MgATP binding site [chemical binding]; other site 439855011853 catalytic site [active] 439855011854 metal binding site [ion binding]; metal-binding site 439855011855 xylulose binding site [chemical binding]; other site 439855011856 homodimer interface [polypeptide binding]; other site 439855011857 xylose isomerase; Provisional; Region: PRK05474 439855011858 xylose isomerase; Region: xylose_isom_A; TIGR02630 439855011859 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 439855011860 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 439855011861 putative ligand binding site [chemical binding]; other site 439855011862 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 439855011863 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855011864 Walker A/P-loop; other site 439855011865 ATP binding site [chemical binding]; other site 439855011866 Q-loop/lid; other site 439855011867 ABC transporter signature motif; other site 439855011868 Walker B; other site 439855011869 D-loop; other site 439855011870 H-loop/switch region; other site 439855011871 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855011872 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855011873 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855011874 TM-ABC transporter signature motif; other site 439855011875 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 439855011876 putative dimerization interface [polypeptide binding]; other site 439855011877 Transcriptional regulators [Transcription]; Region: PurR; COG1609 439855011878 putative ligand binding site [chemical binding]; other site 439855011879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855011880 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855011881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855011882 hypothetical protein; Provisional; Region: PRK10356 439855011883 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 439855011884 alpha-amylase; Reviewed; Region: malS; PRK09505 439855011885 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 439855011886 active site 439855011887 catalytic site [active] 439855011888 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 439855011889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855011890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855011891 homodimer interface [polypeptide binding]; other site 439855011892 catalytic residue [active] 439855011893 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 439855011894 Transcriptional regulator [Transcription]; Region: IclR; COG1414 439855011895 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 439855011896 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855011897 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 439855011898 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 439855011899 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 439855011900 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 439855011901 DctM-like transporters; Region: DctM; pfam06808 439855011902 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 439855011903 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 439855011904 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 439855011905 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 439855011906 putative N- and C-terminal domain interface [polypeptide binding]; other site 439855011907 putative active site [active] 439855011908 MgATP binding site [chemical binding]; other site 439855011909 catalytic site [active] 439855011910 metal binding site [ion binding]; metal-binding site 439855011911 putative xylulose binding site [chemical binding]; other site 439855011912 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 439855011913 active site 439855011914 dimer interface [polypeptide binding]; other site 439855011915 magnesium binding site [ion binding]; other site 439855011916 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 439855011917 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 439855011918 AP (apurinic/apyrimidinic) site pocket; other site 439855011919 DNA interaction; other site 439855011920 Metal-binding active site; metal-binding site 439855011921 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 439855011922 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 439855011923 intersubunit interface [polypeptide binding]; other site 439855011924 active site 439855011925 Zn2+ binding site [ion binding]; other site 439855011926 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 439855011927 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 439855011928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855011929 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 439855011930 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 439855011931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 439855011932 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 439855011933 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 439855011934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 439855011935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855011936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855011937 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 439855011938 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855011939 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855011940 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 439855011941 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 439855011942 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 439855011943 NAD(P) binding site [chemical binding]; other site 439855011944 catalytic residues [active] 439855011945 Fic family protein [Function unknown]; Region: COG3177 439855011946 Fic/DOC family; Region: Fic; pfam02661 439855011947 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 439855011948 putative alcohol dehydrogenase; Provisional; Region: PRK09860 439855011949 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 439855011950 dimer interface [polypeptide binding]; other site 439855011951 active site 439855011952 metal binding site [ion binding]; metal-binding site 439855011953 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 439855011954 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 439855011955 G1 box; other site 439855011956 putative GEF interaction site [polypeptide binding]; other site 439855011957 GTP/Mg2+ binding site [chemical binding]; other site 439855011958 Switch I region; other site 439855011959 G2 box; other site 439855011960 G3 box; other site 439855011961 Switch II region; other site 439855011962 G4 box; other site 439855011963 G5 box; other site 439855011964 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 439855011965 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 439855011966 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 439855011967 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 439855011968 selenocysteine synthase; Provisional; Region: PRK04311 439855011969 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 439855011970 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 439855011971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855011972 catalytic residue [active] 439855011973 putative glutathione S-transferase; Provisional; Region: PRK10357 439855011974 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 439855011975 putative C-terminal domain interface [polypeptide binding]; other site 439855011976 putative GSH binding site (G-site) [chemical binding]; other site 439855011977 putative dimer interface [polypeptide binding]; other site 439855011978 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 439855011979 dimer interface [polypeptide binding]; other site 439855011980 N-terminal domain interface [polypeptide binding]; other site 439855011981 putative substrate binding pocket (H-site) [chemical binding]; other site 439855011982 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 439855011983 Autotransporter beta-domain; Region: Autotransporter; pfam03797 439855011984 Fimbrial protein; Region: Fimbrial; pfam00419 439855011985 Fimbrial protein; Region: Fimbrial; pfam00419 439855011986 Fimbrial protein; Region: Fimbrial; pfam00419 439855011987 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 439855011988 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855011989 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855011990 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 439855011991 PapC N-terminal domain; Region: PapC_N; pfam13954 439855011992 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855011993 PapC C-terminal domain; Region: PapC_C; pfam13953 439855011994 fimbrial protein PefA; Provisional; Region: PRK15214 439855011995 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 439855011996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 439855011997 DNA binding residues [nucleotide binding] 439855011998 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855011999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855012000 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 439855012001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855012002 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855012003 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 439855012004 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 439855012005 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 439855012006 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 439855012007 active site 439855012008 P-loop; other site 439855012009 phosphorylation site [posttranslational modification] 439855012010 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855012011 active site 439855012012 phosphorylation site [posttranslational modification] 439855012013 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 439855012014 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 439855012015 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 439855012016 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 439855012017 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 439855012018 hypothetical protein; Provisional; Region: PRK11020 439855012019 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 439855012020 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 439855012021 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 439855012022 trimer interface [polypeptide binding]; other site 439855012023 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 439855012024 trimer interface [polypeptide binding]; other site 439855012025 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 439855012026 Haemagglutinin; Region: HIM; pfam05662 439855012027 Haemagglutinin; Region: HIM; pfam05662 439855012028 YadA-like C-terminal region; Region: YadA; pfam03895 439855012029 L-lactate permease; Provisional; Region: PRK10420 439855012030 glycolate transporter; Provisional; Region: PRK09695 439855012031 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 439855012032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855012033 DNA-binding site [nucleotide binding]; DNA binding site 439855012034 FCD domain; Region: FCD; pfam07729 439855012035 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 439855012036 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 439855012037 phosphate binding site [ion binding]; other site 439855012038 putative rRNA methylase; Provisional; Region: PRK10358 439855012039 serine acetyltransferase; Provisional; Region: cysE; PRK11132 439855012040 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 439855012041 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 439855012042 trimer interface [polypeptide binding]; other site 439855012043 active site 439855012044 substrate binding site [chemical binding]; other site 439855012045 CoA binding site [chemical binding]; other site 439855012046 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 439855012047 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 439855012048 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 439855012049 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 439855012050 SecA binding site; other site 439855012051 Preprotein binding site; other site 439855012052 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 439855012053 GSH binding site [chemical binding]; other site 439855012054 catalytic residues [active] 439855012055 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 439855012056 active site residue [active] 439855012057 phosphoglyceromutase; Provisional; Region: PRK05434 439855012058 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 439855012059 AmiB activator; Provisional; Region: PRK11637 439855012060 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 439855012061 Peptidase family M23; Region: Peptidase_M23; pfam01551 439855012062 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 439855012063 NodB motif; other site 439855012064 putative active site [active] 439855012065 putative catalytic site [active] 439855012066 Zn binding site [ion binding]; other site 439855012067 putative glycosyl transferase; Provisional; Region: PRK10073 439855012068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 439855012069 active site 439855012070 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 439855012071 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 439855012072 NAD(P) binding site [chemical binding]; other site 439855012073 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 439855012074 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 439855012075 substrate-cofactor binding pocket; other site 439855012076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855012077 catalytic residue [active] 439855012078 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 439855012079 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 439855012080 NADP binding site [chemical binding]; other site 439855012081 homopentamer interface [polypeptide binding]; other site 439855012082 substrate binding site [chemical binding]; other site 439855012083 active site 439855012084 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 439855012085 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 439855012086 putative active site [active] 439855012087 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 439855012088 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 439855012089 putative active site [active] 439855012090 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 439855012091 O-Antigen ligase; Region: Wzy_C; pfam04932 439855012092 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 439855012093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 439855012094 active site 439855012095 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 439855012096 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 439855012097 Ligand binding site; other site 439855012098 metal-binding site 439855012099 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 439855012100 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 439855012101 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 439855012102 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 439855012103 Ligand binding site; other site 439855012104 metal-binding site 439855012105 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 439855012106 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 439855012107 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 439855012108 Ligand binding site; other site 439855012109 metal-binding site 439855012110 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 439855012111 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 439855012112 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 439855012113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 439855012114 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 439855012115 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 439855012116 putative active site [active] 439855012117 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 439855012118 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 439855012119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 439855012120 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 439855012121 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 439855012122 active site 439855012123 (T/H)XGH motif; other site 439855012124 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 439855012125 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 439855012126 DNA binding site [nucleotide binding] 439855012127 catalytic residue [active] 439855012128 H2TH interface [polypeptide binding]; other site 439855012129 putative catalytic residues [active] 439855012130 turnover-facilitating residue; other site 439855012131 intercalation triad [nucleotide binding]; other site 439855012132 8OG recognition residue [nucleotide binding]; other site 439855012133 putative reading head residues; other site 439855012134 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 439855012135 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 439855012136 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 439855012137 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 439855012138 hypothetical protein; Reviewed; Region: PRK00024 439855012139 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 439855012140 MPN+ (JAMM) motif; other site 439855012141 Zinc-binding site [ion binding]; other site 439855012142 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 439855012143 Flavoprotein; Region: Flavoprotein; pfam02441 439855012144 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 439855012145 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 439855012146 trimer interface [polypeptide binding]; other site 439855012147 active site 439855012148 division inhibitor protein; Provisional; Region: slmA; PRK09480 439855012149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855012150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 439855012151 active site 439855012152 ribonuclease PH; Reviewed; Region: rph; PRK00173 439855012153 Ribonuclease PH; Region: RNase_PH_bact; cd11362 439855012154 hexamer interface [polypeptide binding]; other site 439855012155 active site 439855012156 hypothetical protein; Provisional; Region: PRK11820 439855012157 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 439855012158 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 439855012159 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 439855012160 BRO family, N-terminal domain; Region: Bro-N; pfam02498 439855012161 Predicted membrane protein [Function unknown]; Region: COG2860 439855012162 UPF0126 domain; Region: UPF0126; pfam03458 439855012163 UPF0126 domain; Region: UPF0126; pfam03458 439855012164 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 439855012165 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 439855012166 nucleotide binding pocket [chemical binding]; other site 439855012167 K-X-D-G motif; other site 439855012168 catalytic site [active] 439855012169 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 439855012170 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 439855012171 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 439855012172 catalytic site [active] 439855012173 G-X2-G-X-G-K; other site 439855012174 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 439855012175 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 439855012176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 439855012177 Zn2+ binding site [ion binding]; other site 439855012178 Mg2+ binding site [ion binding]; other site 439855012179 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 439855012180 synthetase active site [active] 439855012181 NTP binding site [chemical binding]; other site 439855012182 metal binding site [ion binding]; metal-binding site 439855012183 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 439855012184 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 439855012185 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 439855012186 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 439855012187 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 439855012188 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 439855012189 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 439855012190 generic binding surface II; other site 439855012191 ssDNA binding site; other site 439855012192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855012193 ATP binding site [chemical binding]; other site 439855012194 putative Mg++ binding site [ion binding]; other site 439855012195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855012196 nucleotide binding region [chemical binding]; other site 439855012197 ATP-binding site [chemical binding]; other site 439855012198 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 439855012199 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 439855012200 AsmA family; Region: AsmA; pfam05170 439855012201 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 439855012202 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 439855012203 fructokinase; Reviewed; Region: PRK09557 439855012204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855012205 nucleotide binding site [chemical binding]; other site 439855012206 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 439855012207 intersubunit interface [polypeptide binding]; other site 439855012208 active site 439855012209 zinc binding site [ion binding]; other site 439855012210 Na+ binding site [ion binding]; other site 439855012211 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 439855012212 intersubunit interface [polypeptide binding]; other site 439855012213 active site 439855012214 zinc binding site [ion binding]; other site 439855012215 Na+ binding site [ion binding]; other site 439855012216 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855012217 active site 439855012218 phosphorylation site [posttranslational modification] 439855012219 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 439855012220 HTH domain; Region: HTH_11; pfam08279 439855012221 Mga helix-turn-helix domain; Region: Mga; pfam05043 439855012222 PRD domain; Region: PRD; pfam00874 439855012223 PRD domain; Region: PRD; pfam00874 439855012224 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 439855012225 active site 439855012226 P-loop; other site 439855012227 phosphorylation site [posttranslational modification] 439855012228 putative alpha-glucosidase; Provisional; Region: PRK10658 439855012229 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 439855012230 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 439855012231 active site 439855012232 homotrimer interface [polypeptide binding]; other site 439855012233 catalytic site [active] 439855012234 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 439855012235 putative transporter; Provisional; Region: PRK11462 439855012236 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 439855012237 integrase; Provisional; Region: PRK09692 439855012238 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 439855012239 active site 439855012240 Int/Topo IB signature motif; other site 439855012241 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 439855012242 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 439855012243 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 439855012244 Ash protein family; Region: Phage_ASH; pfam10554 439855012245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 439855012246 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 439855012247 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 439855012248 active site 439855012249 metal binding site [ion binding]; metal-binding site 439855012250 interdomain interaction site; other site 439855012251 D5 N terminal like; Region: D5_N; smart00885 439855012252 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 439855012253 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 439855012254 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 439855012255 sugar efflux transporter; Region: 2A0120; TIGR00899 439855012256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012257 putative substrate translocation pore; other site 439855012258 EamA-like transporter family; Region: EamA; pfam00892 439855012259 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 439855012260 EamA-like transporter family; Region: EamA; pfam00892 439855012261 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 439855012262 lipoprotein, YaeC family; Region: TIGR00363 439855012263 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 439855012264 Tetratricopeptide repeat; Region: TPR_3; pfam07720 439855012265 Tetratricopeptide repeat; Region: TPR_3; pfam07720 439855012266 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 439855012267 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 439855012268 invasion protein regulator; Provisional; Region: PRK12370 439855012269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855012270 DNA binding site [nucleotide binding] 439855012271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855012272 TPR motif; other site 439855012273 binding surface 439855012274 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 439855012275 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 439855012276 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012277 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012278 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012279 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 439855012280 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012281 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012282 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012283 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012284 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012285 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012286 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012287 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012288 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855012289 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 439855012290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012291 putative substrate translocation pore; other site 439855012292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 439855012293 Predicted transcriptional regulator [Transcription]; Region: COG2944 439855012294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855012295 non-specific DNA binding site [nucleotide binding]; other site 439855012296 salt bridge; other site 439855012297 sequence-specific DNA binding site [nucleotide binding]; other site 439855012298 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 439855012299 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 439855012300 cryptic adenine deaminase; Provisional; Region: PRK10027 439855012301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 439855012302 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 439855012303 active site 439855012304 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 439855012305 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 439855012306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012307 putative substrate translocation pore; other site 439855012308 regulatory protein UhpC; Provisional; Region: PRK11663 439855012309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012310 putative substrate translocation pore; other site 439855012311 sensory histidine kinase UhpB; Provisional; Region: PRK11644 439855012312 MASE1; Region: MASE1; pfam05231 439855012313 Histidine kinase; Region: HisKA_3; pfam07730 439855012314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855012315 ATP binding site [chemical binding]; other site 439855012316 Mg2+ binding site [ion binding]; other site 439855012317 G-X-G motif; other site 439855012318 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 439855012319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855012320 active site 439855012321 phosphorylation site [posttranslational modification] 439855012322 intermolecular recognition site; other site 439855012323 dimerization interface [polypeptide binding]; other site 439855012324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855012325 DNA binding residues [nucleotide binding] 439855012326 dimerization interface [polypeptide binding]; other site 439855012327 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 439855012328 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 439855012329 putative valine binding site [chemical binding]; other site 439855012330 dimer interface [polypeptide binding]; other site 439855012331 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 439855012332 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 439855012333 PYR/PP interface [polypeptide binding]; other site 439855012334 dimer interface [polypeptide binding]; other site 439855012335 TPP binding site [chemical binding]; other site 439855012336 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855012337 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 439855012338 TPP-binding site [chemical binding]; other site 439855012339 dimer interface [polypeptide binding]; other site 439855012340 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 439855012341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012342 putative substrate translocation pore; other site 439855012343 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 439855012344 Domain of unknown function (DUF202); Region: DUF202; pfam02656 439855012345 Predicted membrane protein [Function unknown]; Region: COG2149 439855012346 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 439855012347 Sulfatase; Region: Sulfatase; pfam00884 439855012348 putative transporter; Provisional; Region: PRK10484 439855012349 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 439855012350 Na binding site [ion binding]; other site 439855012351 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 439855012352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855012353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855012354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855012355 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 439855012356 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 439855012357 NAD binding site [chemical binding]; other site 439855012358 sugar binding site [chemical binding]; other site 439855012359 divalent metal binding site [ion binding]; other site 439855012360 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855012361 dimer interface [polypeptide binding]; other site 439855012362 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 439855012363 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 439855012364 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855012365 active site turn [active] 439855012366 phosphorylation site [posttranslational modification] 439855012367 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 439855012368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855012369 DNA-binding site [nucleotide binding]; DNA binding site 439855012370 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 439855012371 putative transporter; Validated; Region: PRK03818 439855012372 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 439855012373 TrkA-C domain; Region: TrkA_C; pfam02080 439855012374 TrkA-C domain; Region: TrkA_C; pfam02080 439855012375 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 439855012376 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 439855012377 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 439855012378 putative dimer interface [polypeptide binding]; other site 439855012379 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 439855012380 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 439855012381 putative dimer interface [polypeptide binding]; other site 439855012382 hypothetical protein; Provisional; Region: PRK11616 439855012383 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 439855012384 putative oxidoreductase; Provisional; Region: PRK11445 439855012385 hypothetical protein; Provisional; Region: PRK07236 439855012386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012387 D-galactonate transporter; Region: 2A0114; TIGR00893 439855012388 putative substrate translocation pore; other site 439855012389 galactonate dehydratase; Provisional; Region: PRK14017 439855012390 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 439855012391 putative active site pocket [active] 439855012392 putative metal binding site [ion binding]; other site 439855012393 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 439855012394 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 439855012395 active site 439855012396 intersubunit interface [polypeptide binding]; other site 439855012397 catalytic residue [active] 439855012398 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 439855012399 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 439855012400 Transcriptional regulators [Transcription]; Region: FadR; COG2186 439855012401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855012402 DNA-binding site [nucleotide binding]; DNA binding site 439855012403 FCD domain; Region: FCD; pfam07729 439855012404 hypothetical protein; Provisional; Region: PRK10215 439855012405 sugar phosphate phosphatase; Provisional; Region: PRK10513 439855012406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855012407 active site 439855012408 motif I; other site 439855012409 motif II; other site 439855012410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855012411 hypothetical protein; Provisional; Region: PRK11426 439855012412 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 439855012413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855012414 Mg2+ binding site [ion binding]; other site 439855012415 G-X-G motif; other site 439855012416 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 439855012417 anchoring element; other site 439855012418 dimer interface [polypeptide binding]; other site 439855012419 ATP binding site [chemical binding]; other site 439855012420 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 439855012421 active site 439855012422 putative metal-binding site [ion binding]; other site 439855012423 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 439855012424 recF protein; Region: recf; TIGR00611 439855012425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855012426 Walker A/P-loop; other site 439855012427 ATP binding site [chemical binding]; other site 439855012428 Q-loop/lid; other site 439855012429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855012430 ABC transporter signature motif; other site 439855012431 Walker B; other site 439855012432 D-loop; other site 439855012433 H-loop/switch region; other site 439855012434 DNA polymerase III subunit beta; Validated; Region: PRK05643 439855012435 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 439855012436 putative DNA binding surface [nucleotide binding]; other site 439855012437 dimer interface [polypeptide binding]; other site 439855012438 beta-clamp/clamp loader binding surface; other site 439855012439 beta-clamp/translesion DNA polymerase binding surface; other site 439855012440 DnaA N-terminal domain; Region: DnaA_N; pfam11638 439855012441 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 439855012442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855012443 Walker A motif; other site 439855012444 ATP binding site [chemical binding]; other site 439855012445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 439855012446 Walker B motif; other site 439855012447 arginine finger; other site 439855012448 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 439855012449 DnaA box-binding interface [nucleotide binding]; other site 439855012450 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 439855012451 ribonuclease P; Reviewed; Region: rnpA; PRK01732 439855012452 membrane protein insertase; Provisional; Region: PRK01318 439855012453 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 439855012454 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 439855012455 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 439855012456 trmE is a tRNA modification GTPase; Region: trmE; cd04164 439855012457 G1 box; other site 439855012458 GTP/Mg2+ binding site [chemical binding]; other site 439855012459 Switch I region; other site 439855012460 G2 box; other site 439855012461 Switch II region; other site 439855012462 G3 box; other site 439855012463 G4 box; other site 439855012464 G5 box; other site 439855012465 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 439855012466 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 439855012467 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 439855012468 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 439855012469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 439855012470 catalytic residue [active] 439855012471 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 439855012472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012473 putative substrate translocation pore; other site 439855012474 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 439855012475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855012476 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 439855012477 substrate binding pocket [chemical binding]; other site 439855012478 dimerization interface [polypeptide binding]; other site 439855012479 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 439855012480 Predicted flavoprotein [General function prediction only]; Region: COG0431 439855012481 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 439855012482 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 439855012483 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 439855012484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855012485 active site 439855012486 motif I; other site 439855012487 motif II; other site 439855012488 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 439855012489 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 439855012490 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 439855012491 transcriptional regulator PhoU; Provisional; Region: PRK11115 439855012492 PhoU domain; Region: PhoU; pfam01895 439855012493 PhoU domain; Region: PhoU; pfam01895 439855012494 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 439855012495 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 439855012496 Walker A/P-loop; other site 439855012497 ATP binding site [chemical binding]; other site 439855012498 Q-loop/lid; other site 439855012499 ABC transporter signature motif; other site 439855012500 Walker B; other site 439855012501 D-loop; other site 439855012502 H-loop/switch region; other site 439855012503 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 439855012504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855012505 dimer interface [polypeptide binding]; other site 439855012506 conserved gate region; other site 439855012507 putative PBP binding loops; other site 439855012508 ABC-ATPase subunit interface; other site 439855012509 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 439855012510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855012511 dimer interface [polypeptide binding]; other site 439855012512 conserved gate region; other site 439855012513 putative PBP binding loops; other site 439855012514 ABC-ATPase subunit interface; other site 439855012515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855012516 Fimbrial protein; Region: Fimbrial; cl01416 439855012517 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 439855012518 PapC N-terminal domain; Region: PapC_N; pfam13954 439855012519 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855012520 PapC C-terminal domain; Region: PapC_C; pfam13953 439855012521 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 439855012522 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855012523 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855012524 fimbrial protein; Provisional; Region: lpfA; PRK15289 439855012525 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 439855012526 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 439855012527 glutaminase active site [active] 439855012528 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 439855012529 dimer interface [polypeptide binding]; other site 439855012530 active site 439855012531 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 439855012532 dimer interface [polypeptide binding]; other site 439855012533 active site 439855012534 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 439855012535 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 439855012536 Substrate binding site; other site 439855012537 Mg++ binding site; other site 439855012538 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 439855012539 active site 439855012540 substrate binding site [chemical binding]; other site 439855012541 CoA binding site [chemical binding]; other site 439855012542 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 439855012543 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 439855012544 gamma subunit interface [polypeptide binding]; other site 439855012545 epsilon subunit interface [polypeptide binding]; other site 439855012546 LBP interface [polypeptide binding]; other site 439855012547 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 439855012548 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 439855012549 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 439855012550 alpha subunit interaction interface [polypeptide binding]; other site 439855012551 Walker A motif; other site 439855012552 ATP binding site [chemical binding]; other site 439855012553 Walker B motif; other site 439855012554 inhibitor binding site; inhibition site 439855012555 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 439855012556 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 439855012557 core domain interface [polypeptide binding]; other site 439855012558 delta subunit interface [polypeptide binding]; other site 439855012559 epsilon subunit interface [polypeptide binding]; other site 439855012560 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 439855012561 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 439855012562 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 439855012563 beta subunit interaction interface [polypeptide binding]; other site 439855012564 Walker A motif; other site 439855012565 ATP binding site [chemical binding]; other site 439855012566 Walker B motif; other site 439855012567 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 439855012568 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 439855012569 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 439855012570 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 439855012571 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 439855012572 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 439855012573 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 439855012574 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 439855012575 ATP synthase I chain; Region: ATP_synt_I; cl09170 439855012576 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 439855012577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855012578 S-adenosylmethionine binding site [chemical binding]; other site 439855012579 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 439855012580 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 439855012581 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 439855012582 FMN-binding protein MioC; Provisional; Region: PRK09004 439855012583 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 439855012584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855012585 putative DNA binding site [nucleotide binding]; other site 439855012586 putative Zn2+ binding site [ion binding]; other site 439855012587 AsnC family; Region: AsnC_trans_reg; pfam01037 439855012588 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 439855012589 dimer interface [polypeptide binding]; other site 439855012590 active site 439855012591 hypothetical protein; Provisional; Region: yieM; PRK10997 439855012592 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 439855012593 metal ion-dependent adhesion site (MIDAS); other site 439855012594 regulatory ATPase RavA; Provisional; Region: PRK13531 439855012595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855012596 Walker A motif; other site 439855012597 ATP binding site [chemical binding]; other site 439855012598 Walker B motif; other site 439855012599 arginine finger; other site 439855012600 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 439855012601 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 439855012602 potassium uptake protein; Region: kup; TIGR00794 439855012603 D-ribose pyranase; Provisional; Region: PRK11797 439855012604 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 439855012605 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855012606 Walker A/P-loop; other site 439855012607 ATP binding site [chemical binding]; other site 439855012608 Q-loop/lid; other site 439855012609 ABC transporter signature motif; other site 439855012610 Walker B; other site 439855012611 D-loop; other site 439855012612 H-loop/switch region; other site 439855012613 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855012614 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855012615 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855012616 TM-ABC transporter signature motif; other site 439855012617 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 439855012618 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 439855012619 ligand binding site [chemical binding]; other site 439855012620 dimerization interface [polypeptide binding]; other site 439855012621 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 439855012622 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855012623 substrate binding site [chemical binding]; other site 439855012624 dimer interface [polypeptide binding]; other site 439855012625 ATP binding site [chemical binding]; other site 439855012626 transcriptional repressor RbsR; Provisional; Region: PRK10423 439855012627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855012628 DNA binding site [nucleotide binding] 439855012629 domain linker motif; other site 439855012630 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 439855012631 dimerization interface [polypeptide binding]; other site 439855012632 ligand binding site [chemical binding]; other site 439855012633 putative transporter; Provisional; Region: PRK10504 439855012634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012635 putative substrate translocation pore; other site 439855012636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855012637 Transcriptional regulators [Transcription]; Region: FadR; COG2186 439855012638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855012639 DNA-binding site [nucleotide binding]; DNA binding site 439855012640 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855012641 transcriptional regulator HdfR; Provisional; Region: PRK03601 439855012642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855012643 LysR substrate binding domain; Region: LysR_substrate; pfam03466 439855012644 dimerization interface [polypeptide binding]; other site 439855012645 hypothetical protein; Provisional; Region: PRK11027 439855012646 putative ATP-dependent protease; Provisional; Region: PRK09862 439855012647 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 439855012648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855012649 Walker A motif; other site 439855012650 ATP binding site [chemical binding]; other site 439855012651 Walker B motif; other site 439855012652 arginine finger; other site 439855012653 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 439855012654 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 439855012655 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 439855012656 PYR/PP interface [polypeptide binding]; other site 439855012657 dimer interface [polypeptide binding]; other site 439855012658 TPP binding site [chemical binding]; other site 439855012659 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855012660 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 439855012661 TPP-binding site [chemical binding]; other site 439855012662 dimer interface [polypeptide binding]; other site 439855012663 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 439855012664 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 439855012665 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 439855012666 homodimer interface [polypeptide binding]; other site 439855012667 substrate-cofactor binding pocket; other site 439855012668 catalytic residue [active] 439855012669 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 439855012670 threonine dehydratase; Reviewed; Region: PRK09224 439855012671 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 439855012672 tetramer interface [polypeptide binding]; other site 439855012673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855012674 catalytic residue [active] 439855012675 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 439855012676 putative Ile/Val binding site [chemical binding]; other site 439855012677 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 439855012678 putative Ile/Val binding site [chemical binding]; other site 439855012679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855012680 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 439855012681 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 439855012682 putative dimerization interface [polypeptide binding]; other site 439855012683 ketol-acid reductoisomerase; Validated; Region: PRK05225 439855012684 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 439855012685 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 439855012686 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 439855012687 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 439855012688 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 439855012689 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 439855012690 Part of AAA domain; Region: AAA_19; pfam13245 439855012691 Family description; Region: UvrD_C_2; pfam13538 439855012692 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 439855012693 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 439855012694 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 439855012695 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 439855012696 ATP binding site [chemical binding]; other site 439855012697 Mg++ binding site [ion binding]; other site 439855012698 motif III; other site 439855012699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855012700 nucleotide binding region [chemical binding]; other site 439855012701 ATP-binding site [chemical binding]; other site 439855012702 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 439855012703 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 439855012704 catalytic residues [active] 439855012705 transcription termination factor Rho; Provisional; Region: rho; PRK09376 439855012706 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 439855012707 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 439855012708 RNA binding site [nucleotide binding]; other site 439855012709 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 439855012710 multimer interface [polypeptide binding]; other site 439855012711 Walker A motif; other site 439855012712 ATP binding site [chemical binding]; other site 439855012713 Walker B motif; other site 439855012714 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 439855012715 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 439855012716 Mg++ binding site [ion binding]; other site 439855012717 putative catalytic motif [active] 439855012718 substrate binding site [chemical binding]; other site 439855012719 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 439855012720 Chain length determinant protein; Region: Wzz; pfam02706 439855012721 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 439855012722 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 439855012723 active site 439855012724 homodimer interface [polypeptide binding]; other site 439855012725 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 439855012726 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 439855012727 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 439855012728 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 439855012729 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 439855012730 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 439855012731 NAD binding site [chemical binding]; other site 439855012732 substrate binding site [chemical binding]; other site 439855012733 homodimer interface [polypeptide binding]; other site 439855012734 active site 439855012735 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 439855012736 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 439855012737 substrate binding site; other site 439855012738 tetramer interface; other site 439855012739 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 439855012740 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 439855012741 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 439855012742 inhibitor-cofactor binding pocket; inhibition site 439855012743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855012744 catalytic residue [active] 439855012745 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 439855012746 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 439855012747 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 439855012748 putative common antigen polymerase; Provisional; Region: PRK02975 439855012749 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 439855012750 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 439855012751 putative transport protein YifK; Provisional; Region: PRK10746 439855012752 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 439855012753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855012754 FeS/SAM binding site; other site 439855012755 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 439855012756 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 439855012757 Sulfatase; Region: Sulfatase; pfam00884 439855012758 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 439855012759 HemY protein N-terminus; Region: HemY_N; pfam07219 439855012760 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 439855012761 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 439855012762 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 439855012763 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 439855012764 active site 439855012765 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 439855012766 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 439855012767 domain interfaces; other site 439855012768 active site 439855012769 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 439855012770 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 439855012771 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 439855012772 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 439855012773 putative iron binding site [ion binding]; other site 439855012774 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 439855012775 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 439855012776 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 439855012777 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 439855012778 hypothetical protein; Provisional; Region: PRK10963 439855012779 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 439855012780 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 439855012781 active site 439855012782 DNA binding site [nucleotide binding] 439855012783 Int/Topo IB signature motif; other site 439855012784 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 439855012785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855012786 motif II; other site 439855012787 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 439855012788 Part of AAA domain; Region: AAA_19; pfam13245 439855012789 Family description; Region: UvrD_C_2; pfam13538 439855012790 Uncharacterized conserved protein [Function unknown]; Region: COG1912 439855012791 Predicted periplasmic protein [Function unknown]; Region: COG3698 439855012792 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 439855012793 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 439855012794 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 439855012795 Cl binding site [ion binding]; other site 439855012796 oligomer interface [polypeptide binding]; other site 439855012797 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 439855012798 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 439855012799 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 439855012800 EamA-like transporter family; Region: EamA; cl17759 439855012801 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 439855012802 CoenzymeA binding site [chemical binding]; other site 439855012803 subunit interaction site [polypeptide binding]; other site 439855012804 PHB binding site; other site 439855012805 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 439855012806 dimerization interface [polypeptide binding]; other site 439855012807 substrate binding site [chemical binding]; other site 439855012808 active site 439855012809 calcium binding site [ion binding]; other site 439855012810 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 439855012811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855012812 ATP binding site [chemical binding]; other site 439855012813 putative Mg++ binding site [ion binding]; other site 439855012814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855012815 nucleotide binding region [chemical binding]; other site 439855012816 ATP-binding site [chemical binding]; other site 439855012817 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 439855012818 Helicase and RNase D C-terminal; Region: HRDC; smart00341 439855012819 threonine efflux system; Provisional; Region: PRK10229 439855012820 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 439855012821 lysophospholipase L2; Provisional; Region: PRK10749 439855012822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 439855012823 putative hydrolase; Provisional; Region: PRK10976 439855012824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855012825 active site 439855012826 motif I; other site 439855012827 motif II; other site 439855012828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855012829 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 439855012830 EamA-like transporter family; Region: EamA; pfam00892 439855012831 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 439855012832 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 439855012833 THF binding site; other site 439855012834 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 439855012835 substrate binding site [chemical binding]; other site 439855012836 THF binding site; other site 439855012837 zinc-binding site [ion binding]; other site 439855012838 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 439855012839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855012840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 439855012841 dimerization interface [polypeptide binding]; other site 439855012842 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 439855012843 Na binding site [ion binding]; other site 439855012844 allophanate hydrolase; Provisional; Region: PRK08186 439855012845 carbamate kinase; Reviewed; Region: PRK12686 439855012846 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 439855012847 putative substrate binding site [chemical binding]; other site 439855012848 nucleotide binding site [chemical binding]; other site 439855012849 nucleotide binding site [chemical binding]; other site 439855012850 homodimer interface [polypeptide binding]; other site 439855012851 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 439855012852 CoA binding domain; Region: CoA_binding; pfam02629 439855012853 CoA-ligase; Region: Ligase_CoA; pfam00549 439855012854 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 439855012855 Isochorismatase family; Region: Isochorismatase; pfam00857 439855012856 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 439855012857 catalytic triad [active] 439855012858 conserved cis-peptide bond; other site 439855012859 Dienelactone hydrolase family; Region: DLH; pfam01738 439855012860 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 439855012861 uridine phosphorylase; Provisional; Region: PRK11178 439855012862 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 439855012863 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 439855012864 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 439855012865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 439855012866 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 439855012867 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 439855012868 active site 439855012869 intersubunit interface [polypeptide binding]; other site 439855012870 catalytic residue [active] 439855012871 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 439855012872 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 439855012873 Transcriptional regulator [Transcription]; Region: IclR; COG1414 439855012874 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 439855012875 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855012876 DNA recombination protein RmuC; Provisional; Region: PRK10361 439855012877 RmuC family; Region: RmuC; pfam02646 439855012878 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 439855012879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855012880 S-adenosylmethionine binding site [chemical binding]; other site 439855012881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 439855012882 SCP-2 sterol transfer family; Region: SCP2; pfam02036 439855012883 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 439855012884 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 439855012885 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 439855012886 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 439855012887 sec-independent translocase; Provisional; Region: PRK01770 439855012888 sec-independent translocase; Provisional; Region: tatB; PRK00404 439855012889 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 439855012890 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 439855012891 active site 439855012892 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 439855012893 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 439855012894 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 439855012895 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 439855012896 FMN reductase; Validated; Region: fre; PRK08051 439855012897 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 439855012898 FAD binding pocket [chemical binding]; other site 439855012899 FAD binding motif [chemical binding]; other site 439855012900 phosphate binding motif [ion binding]; other site 439855012901 beta-alpha-beta structure motif; other site 439855012902 NAD binding pocket [chemical binding]; other site 439855012903 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 439855012904 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 439855012905 dimer interface [polypeptide binding]; other site 439855012906 active site 439855012907 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 439855012908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 439855012909 substrate binding site [chemical binding]; other site 439855012910 oxyanion hole (OAH) forming residues; other site 439855012911 trimer interface [polypeptide binding]; other site 439855012912 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 439855012913 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 439855012914 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 439855012915 proline dipeptidase; Provisional; Region: PRK13607 439855012916 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 439855012917 active site 439855012918 hypothetical protein; Provisional; Region: PRK11568 439855012919 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 439855012920 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 439855012921 potassium transporter; Provisional; Region: PRK10750 439855012922 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 439855012923 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 439855012924 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 439855012925 Walker A motif; other site 439855012926 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 439855012927 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 439855012928 GTP binding site; other site 439855012929 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 439855012930 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 439855012931 serine/threonine protein kinase; Provisional; Region: PRK11768 439855012932 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 439855012933 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 439855012934 catalytic residues [active] 439855012935 hinge region; other site 439855012936 alpha helical domain; other site 439855012937 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 439855012938 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 439855012939 putative acyl-acceptor binding pocket; other site 439855012940 DNA polymerase I; Provisional; Region: PRK05755 439855012941 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 439855012942 active site 439855012943 metal binding site 1 [ion binding]; metal-binding site 439855012944 putative 5' ssDNA interaction site; other site 439855012945 metal binding site 3; metal-binding site 439855012946 metal binding site 2 [ion binding]; metal-binding site 439855012947 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 439855012948 putative DNA binding site [nucleotide binding]; other site 439855012949 putative metal binding site [ion binding]; other site 439855012950 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 439855012951 active site 439855012952 catalytic site [active] 439855012953 substrate binding site [chemical binding]; other site 439855012954 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 439855012955 active site 439855012956 DNA binding site [nucleotide binding] 439855012957 catalytic site [active] 439855012958 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 439855012959 G1 box; other site 439855012960 GTP/Mg2+ binding site [chemical binding]; other site 439855012961 Switch I region; other site 439855012962 G2 box; other site 439855012963 G3 box; other site 439855012964 Switch II region; other site 439855012965 G4 box; other site 439855012966 G5 box; other site 439855012967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 439855012968 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 439855012969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855012970 FeS/SAM binding site; other site 439855012971 HemN C-terminal domain; Region: HemN_C; pfam06969 439855012972 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 439855012973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855012974 active site 439855012975 phosphorylation site [posttranslational modification] 439855012976 intermolecular recognition site; other site 439855012977 dimerization interface [polypeptide binding]; other site 439855012978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855012979 Walker A motif; other site 439855012980 ATP binding site [chemical binding]; other site 439855012981 Walker B motif; other site 439855012982 arginine finger; other site 439855012983 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855012984 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 439855012985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 439855012986 putative active site [active] 439855012987 heme pocket [chemical binding]; other site 439855012988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855012989 dimer interface [polypeptide binding]; other site 439855012990 phosphorylation site [posttranslational modification] 439855012991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855012992 ATP binding site [chemical binding]; other site 439855012993 Mg2+ binding site [ion binding]; other site 439855012994 G-X-G motif; other site 439855012995 glutamine synthetase; Provisional; Region: glnA; PRK09469 439855012996 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 439855012997 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 439855012998 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 439855012999 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 439855013000 G1 box; other site 439855013001 putative GEF interaction site [polypeptide binding]; other site 439855013002 GTP/Mg2+ binding site [chemical binding]; other site 439855013003 Switch I region; other site 439855013004 G2 box; other site 439855013005 G3 box; other site 439855013006 Switch II region; other site 439855013007 G4 box; other site 439855013008 G5 box; other site 439855013009 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 439855013010 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 439855013011 transcriptional regulator protein; Region: phnR; TIGR03337 439855013012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855013013 DNA-binding site [nucleotide binding]; DNA binding site 439855013014 UTRA domain; Region: UTRA; pfam07702 439855013015 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 439855013016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855013017 putative substrate translocation pore; other site 439855013018 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 439855013019 outer membrane porin L; Provisional; Region: ompL; PRK09980 439855013020 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 439855013021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855013022 putative substrate translocation pore; other site 439855013023 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 439855013024 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 439855013025 alpha-glucosidase; Provisional; Region: PRK10426 439855013026 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 439855013027 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 439855013028 putative active site [active] 439855013029 putative catalytic site [active] 439855013030 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 439855013031 active site 439855013032 catalytic residues [active] 439855013033 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 439855013034 dimerization interface [polypeptide binding]; other site 439855013035 putative active cleft [active] 439855013036 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 439855013037 catalytic residue [active] 439855013038 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 439855013039 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 439855013040 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 439855013041 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 439855013042 substrate binding site [chemical binding]; other site 439855013043 ATP binding site [chemical binding]; other site 439855013044 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 439855013045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855013046 putative DNA binding site [nucleotide binding]; other site 439855013047 putative Zn2+ binding site [ion binding]; other site 439855013048 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855013049 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 439855013050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855013051 motif II; other site 439855013052 hypothetical protein; Reviewed; Region: PRK01637 439855013053 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 439855013054 putative active site [active] 439855013055 dimerization interface [polypeptide binding]; other site 439855013056 putative tRNAtyr binding site [nucleotide binding]; other site 439855013057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855013058 Coenzyme A binding pocket [chemical binding]; other site 439855013059 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 439855013060 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 439855013061 LexA regulated protein; Provisional; Region: PRK11675 439855013062 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 439855013063 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 439855013064 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 439855013065 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 439855013066 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 439855013067 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 439855013068 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 439855013069 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 439855013070 [4Fe-4S] binding site [ion binding]; other site 439855013071 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 439855013072 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 439855013073 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 439855013074 molybdopterin cofactor binding site; other site 439855013075 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 439855013076 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 439855013077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 439855013078 Tetratricopeptide repeat; Region: TPR_12; pfam13424 439855013079 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 439855013080 putative frv operon regulatory protein; Provisional; Region: PRK09863 439855013081 HTH domain; Region: HTH_11; pfam08279 439855013082 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855013083 active site 439855013084 phosphorylation site [posttranslational modification] 439855013085 putative peptidase; Provisional; Region: PRK09864 439855013086 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 439855013087 oligomer interface [polypeptide binding]; other site 439855013088 active site 439855013089 metal binding site [ion binding]; metal-binding site 439855013090 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 439855013091 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 439855013092 active site 439855013093 P-loop; other site 439855013094 phosphorylation site [posttranslational modification] 439855013095 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 439855013096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855013097 active site 439855013098 phosphorylation site [posttranslational modification] 439855013099 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 439855013100 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 439855013101 intersubunit interface [polypeptide binding]; other site 439855013102 active site 439855013103 Zn2+ binding site [ion binding]; other site 439855013104 L-rhamnose isomerase; Provisional; Region: PRK01076 439855013105 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 439855013106 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 439855013107 N- and C-terminal domain interface [polypeptide binding]; other site 439855013108 active site 439855013109 putative catalytic site [active] 439855013110 metal binding site [ion binding]; metal-binding site 439855013111 ATP binding site [chemical binding]; other site 439855013112 rhamnulokinase; Provisional; Region: rhaB; PRK10640 439855013113 carbohydrate binding site [chemical binding]; other site 439855013114 transcriptional activator RhaS; Provisional; Region: PRK13503 439855013115 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 439855013116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013118 transcriptional activator RhaR; Provisional; Region: PRK13500 439855013119 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 439855013120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013122 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 439855013123 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 439855013124 superoxide dismutase; Provisional; Region: PRK10925 439855013125 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 439855013126 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 439855013127 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 439855013128 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 439855013129 MOSC domain; Region: MOSC; pfam03473 439855013130 3-alpha domain; Region: 3-alpha; pfam03475 439855013131 two-component sensor protein; Provisional; Region: cpxA; PRK09470 439855013132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855013133 dimerization interface [polypeptide binding]; other site 439855013134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855013135 dimer interface [polypeptide binding]; other site 439855013136 phosphorylation site [posttranslational modification] 439855013137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855013138 ATP binding site [chemical binding]; other site 439855013139 Mg2+ binding site [ion binding]; other site 439855013140 G-X-G motif; other site 439855013141 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 439855013142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855013143 active site 439855013144 intermolecular recognition site; other site 439855013145 dimerization interface [polypeptide binding]; other site 439855013146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855013147 DNA binding site [nucleotide binding] 439855013148 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 439855013149 dimer interface [polypeptide binding]; other site 439855013150 integrase; Provisional; Region: int; PHA02601 439855013151 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 439855013152 active site 439855013153 catalytic residues [active] 439855013154 Int/Topo IB signature motif; other site 439855013155 dimer interface [polypeptide binding]; other site 439855013156 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 439855013157 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 439855013158 DksA-like zinc finger domain containing protein; Region: PHA00080 439855013159 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 439855013160 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 439855013161 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 439855013162 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 439855013163 cofactor binding site; other site 439855013164 DNA binding site [nucleotide binding] 439855013165 substrate interaction site [chemical binding]; other site 439855013166 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 439855013167 ParB-like nuclease domain; Region: ParB; smart00470 439855013168 portal vertex protein; Provisional; Region: Q; PHA02536 439855013169 Phage portal protein; Region: Phage_portal; pfam04860 439855013170 terminase ATPase subunit; Provisional; Region: P; PHA02535 439855013171 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 439855013172 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 439855013173 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 439855013174 terminase endonuclease subunit; Provisional; Region: M; PHA02537 439855013175 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 439855013176 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 439855013177 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 439855013178 Phage holin family 2; Region: Phage_holin_2; pfam04550 439855013179 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 439855013180 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855013181 catalytic residue [active] 439855013182 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 439855013183 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 439855013184 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 439855013185 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 439855013186 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 439855013187 baseplate wedge subunit; Provisional; Region: W; PHA02516 439855013188 baseplate assembly protein; Provisional; Region: J; PHA02568 439855013189 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 439855013190 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 439855013191 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 439855013192 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 439855013193 aspartate aminotransferase; Provisional; Region: PRK06207 439855013194 major tail sheath protein; Provisional; Region: FI; PHA02560 439855013195 major tail tube protein; Provisional; Region: FII; PHA02600 439855013196 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 439855013197 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 439855013198 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 439855013199 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 439855013200 tail protein; Provisional; Region: D; PHA02561 439855013201 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 439855013202 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 439855013203 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 439855013204 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 439855013205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855013206 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 439855013207 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 439855013208 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 439855013209 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 439855013210 active site 439855013211 ADP/pyrophosphate binding site [chemical binding]; other site 439855013212 dimerization interface [polypeptide binding]; other site 439855013213 allosteric effector site; other site 439855013214 fructose-1,6-bisphosphate binding site; other site 439855013215 sulfate transporter subunit; Provisional; Region: PRK10752 439855013216 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 439855013217 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 439855013218 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 439855013219 triosephosphate isomerase; Provisional; Region: PRK14567 439855013220 substrate binding site [chemical binding]; other site 439855013221 dimer interface [polypeptide binding]; other site 439855013222 catalytic triad [active] 439855013223 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 439855013224 Predicted membrane protein [Function unknown]; Region: COG3152 439855013225 hypothetical protein; Provisional; Region: PRK09981 439855013226 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 439855013227 Ligand Binding Site [chemical binding]; other site 439855013228 ferredoxin-NADP reductase; Provisional; Region: PRK10926 439855013229 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 439855013230 FAD binding pocket [chemical binding]; other site 439855013231 FAD binding motif [chemical binding]; other site 439855013232 phosphate binding motif [ion binding]; other site 439855013233 beta-alpha-beta structure motif; other site 439855013234 NAD binding pocket [chemical binding]; other site 439855013235 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 439855013236 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 439855013237 putative active site [active] 439855013238 glycerol kinase; Provisional; Region: glpK; PRK00047 439855013239 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 439855013240 N- and C-terminal domain interface [polypeptide binding]; other site 439855013241 active site 439855013242 MgATP binding site [chemical binding]; other site 439855013243 catalytic site [active] 439855013244 metal binding site [ion binding]; metal-binding site 439855013245 glycerol binding site [chemical binding]; other site 439855013246 homotetramer interface [polypeptide binding]; other site 439855013247 homodimer interface [polypeptide binding]; other site 439855013248 FBP binding site [chemical binding]; other site 439855013249 protein IIAGlc interface [polypeptide binding]; other site 439855013250 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 439855013251 amphipathic channel; other site 439855013252 Asn-Pro-Ala signature motifs; other site 439855013253 septal ring assembly protein ZapB; Provisional; Region: PRK15422 439855013254 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 439855013255 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 439855013256 UbiA prenyltransferase family; Region: UbiA; pfam01040 439855013257 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 439855013258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855013259 Walker A motif; other site 439855013260 ATP binding site [chemical binding]; other site 439855013261 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 439855013262 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 439855013263 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 439855013264 active site 439855013265 HslU subunit interaction site [polypeptide binding]; other site 439855013266 essential cell division protein FtsN; Provisional; Region: PRK10927 439855013267 cell division protein FtsN; Provisional; Region: PRK12757 439855013268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855013269 DNA binding site [nucleotide binding] 439855013270 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 439855013271 domain linker motif; other site 439855013272 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 439855013273 dimerization interface [polypeptide binding]; other site 439855013274 ligand binding site [chemical binding]; other site 439855013275 primosome assembly protein PriA; Validated; Region: PRK05580 439855013276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855013277 ATP binding site [chemical binding]; other site 439855013278 putative Mg++ binding site [ion binding]; other site 439855013279 helicase superfamily c-terminal domain; Region: HELICc; smart00490 439855013280 ATP-binding site [chemical binding]; other site 439855013281 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 439855013282 hypothetical protein; Provisional; Region: PRK10030 439855013283 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 439855013284 dimerization interface [polypeptide binding]; other site 439855013285 DNA binding site [nucleotide binding] 439855013286 corepressor binding sites; other site 439855013287 cystathionine gamma-synthase; Provisional; Region: PRK08045 439855013288 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 439855013289 homodimer interface [polypeptide binding]; other site 439855013290 substrate-cofactor binding pocket; other site 439855013291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855013292 catalytic residue [active] 439855013293 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 439855013294 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 439855013295 putative catalytic residues [active] 439855013296 putative nucleotide binding site [chemical binding]; other site 439855013297 putative aspartate binding site [chemical binding]; other site 439855013298 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 439855013299 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 439855013300 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 439855013301 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 439855013302 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 439855013303 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 439855013304 active site 439855013305 metal binding site [ion binding]; metal-binding site 439855013306 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 439855013307 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 439855013308 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 439855013309 active site 439855013310 metal binding site [ion binding]; metal-binding site 439855013311 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 439855013312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 439855013313 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 439855013314 active site 439855013315 metal binding site [ion binding]; metal-binding site 439855013316 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 439855013317 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 439855013318 FAD binding site [chemical binding]; other site 439855013319 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 439855013320 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 439855013321 heme binding site [chemical binding]; other site 439855013322 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 439855013323 EamA-like transporter family; Region: EamA; pfam00892 439855013324 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 439855013325 EamA-like transporter family; Region: EamA; pfam00892 439855013326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 439855013327 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 439855013328 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 439855013329 dimer interface [polypeptide binding]; other site 439855013330 active site 439855013331 metal binding site [ion binding]; metal-binding site 439855013332 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 439855013333 active site 439855013334 intersubunit interactions; other site 439855013335 catalytic residue [active] 439855013336 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855013337 dimerization domain swap beta strand [polypeptide binding]; other site 439855013338 regulatory protein interface [polypeptide binding]; other site 439855013339 active site 439855013340 regulatory phosphorylation site [posttranslational modification]; other site 439855013341 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 439855013342 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 439855013343 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855013344 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 439855013345 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855013346 active site 439855013347 phosphorylation site [posttranslational modification] 439855013348 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 439855013349 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 439855013350 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 439855013351 active site 439855013352 P-loop; other site 439855013353 phosphorylation site [posttranslational modification] 439855013354 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 439855013355 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 439855013356 dimer interface [polypeptide binding]; other site 439855013357 active site 439855013358 glycine loop; other site 439855013359 pyruvate formate lyase II activase; Provisional; Region: PRK10076 439855013360 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 439855013361 active site 439855013362 P-loop; other site 439855013363 phosphorylation site [posttranslational modification] 439855013364 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855013365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013366 hypothetical protein; Provisional; Region: PRK10649 439855013367 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 439855013368 Sulfatase; Region: Sulfatase; pfam00884 439855013369 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 439855013370 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 439855013371 acetylornithine deacetylase; Provisional; Region: PRK05111 439855013372 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 439855013373 metal binding site [ion binding]; metal-binding site 439855013374 putative dimer interface [polypeptide binding]; other site 439855013375 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 439855013376 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 439855013377 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 439855013378 nucleotide binding site [chemical binding]; other site 439855013379 N-acetyl-L-glutamate binding site [chemical binding]; other site 439855013380 argininosuccinate lyase; Provisional; Region: PRK04833 439855013381 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 439855013382 active sites [active] 439855013383 tetramer interface [polypeptide binding]; other site 439855013384 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 439855013385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855013386 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 439855013387 dimerization interface [polypeptide binding]; other site 439855013388 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 439855013389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 439855013390 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 439855013391 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 439855013392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855013393 hypothetical protein; Provisional; Region: PRK11056 439855013394 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 439855013395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855013396 S-adenosylmethionine binding site [chemical binding]; other site 439855013397 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 439855013398 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 439855013399 N-terminal plug; other site 439855013400 ligand-binding site [chemical binding]; other site 439855013401 glutamate racemase; Provisional; Region: PRK00865 439855013402 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 439855013403 FAD binding domain; Region: FAD_binding_4; pfam01565 439855013404 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 439855013405 Biotin operon repressor [Transcription]; Region: BirA; COG1654 439855013406 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 439855013407 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 439855013408 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 439855013409 pantothenate kinase; Provisional; Region: PRK05439 439855013410 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 439855013411 ATP-binding site [chemical binding]; other site 439855013412 CoA-binding site [chemical binding]; other site 439855013413 Mg2+-binding site [ion binding]; other site 439855013414 elongation factor Tu; Reviewed; Region: PRK00049 439855013415 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 439855013416 G1 box; other site 439855013417 GEF interaction site [polypeptide binding]; other site 439855013418 GTP/Mg2+ binding site [chemical binding]; other site 439855013419 Switch I region; other site 439855013420 G2 box; other site 439855013421 G3 box; other site 439855013422 Switch II region; other site 439855013423 G4 box; other site 439855013424 G5 box; other site 439855013425 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 439855013426 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 439855013427 Antibiotic Binding Site [chemical binding]; other site 439855013428 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 439855013429 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 439855013430 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 439855013431 putative homodimer interface [polypeptide binding]; other site 439855013432 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 439855013433 heterodimer interface [polypeptide binding]; other site 439855013434 homodimer interface [polypeptide binding]; other site 439855013435 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 439855013436 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 439855013437 23S rRNA interface [nucleotide binding]; other site 439855013438 L7/L12 interface [polypeptide binding]; other site 439855013439 putative thiostrepton binding site; other site 439855013440 L25 interface [polypeptide binding]; other site 439855013441 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 439855013442 mRNA/rRNA interface [nucleotide binding]; other site 439855013443 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 439855013444 23S rRNA interface [nucleotide binding]; other site 439855013445 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 439855013446 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 439855013447 core dimer interface [polypeptide binding]; other site 439855013448 peripheral dimer interface [polypeptide binding]; other site 439855013449 L10 interface [polypeptide binding]; other site 439855013450 L11 interface [polypeptide binding]; other site 439855013451 putative EF-Tu interaction site [polypeptide binding]; other site 439855013452 putative EF-G interaction site [polypeptide binding]; other site 439855013453 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 439855013454 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 439855013455 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 439855013456 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 439855013457 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 439855013458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 439855013459 RPB3 interaction site [polypeptide binding]; other site 439855013460 RPB1 interaction site [polypeptide binding]; other site 439855013461 RPB11 interaction site [polypeptide binding]; other site 439855013462 RPB10 interaction site [polypeptide binding]; other site 439855013463 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 439855013464 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 439855013465 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 439855013466 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 439855013467 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 439855013468 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 439855013469 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 439855013470 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 439855013471 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 439855013472 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 439855013473 DNA binding site [nucleotide binding] 439855013474 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 439855013475 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 439855013476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855013477 FeS/SAM binding site; other site 439855013478 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 439855013479 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 439855013480 ThiS interaction site; other site 439855013481 putative active site [active] 439855013482 tetramer interface [polypeptide binding]; other site 439855013483 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 439855013484 thiS-thiF/thiG interaction site; other site 439855013485 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 439855013486 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 439855013487 ATP binding site [chemical binding]; other site 439855013488 substrate interface [chemical binding]; other site 439855013489 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 439855013490 thiamine phosphate binding site [chemical binding]; other site 439855013491 active site 439855013492 pyrophosphate binding site [ion binding]; other site 439855013493 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 439855013494 ThiC-associated domain; Region: ThiC-associated; pfam13667 439855013495 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 439855013496 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 439855013497 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 439855013498 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 439855013499 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 439855013500 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 439855013501 putative NADH binding site [chemical binding]; other site 439855013502 putative active site [active] 439855013503 nudix motif; other site 439855013504 putative metal binding site [ion binding]; other site 439855013505 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 439855013506 substrate binding site [chemical binding]; other site 439855013507 active site 439855013508 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 439855013509 Active_site [active] 439855013510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 439855013511 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 439855013512 IHF dimer interface [polypeptide binding]; other site 439855013513 IHF - DNA interface [nucleotide binding]; other site 439855013514 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 439855013515 zinc resistance protein; Provisional; Region: zraP; PRK11546 439855013516 dimer interface [polypeptide binding]; other site 439855013517 sensor protein ZraS; Provisional; Region: PRK10364 439855013518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855013519 dimer interface [polypeptide binding]; other site 439855013520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855013521 ATP binding site [chemical binding]; other site 439855013522 Mg2+ binding site [ion binding]; other site 439855013523 G-X-G motif; other site 439855013524 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 439855013525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855013526 active site 439855013527 phosphorylation site [posttranslational modification] 439855013528 intermolecular recognition site; other site 439855013529 dimerization interface [polypeptide binding]; other site 439855013530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855013531 Walker A motif; other site 439855013532 ATP binding site [chemical binding]; other site 439855013533 Walker B motif; other site 439855013534 arginine finger; other site 439855013535 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855013536 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 439855013537 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 439855013538 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 439855013539 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 439855013540 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 439855013541 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 439855013542 purine monophosphate binding site [chemical binding]; other site 439855013543 dimer interface [polypeptide binding]; other site 439855013544 putative catalytic residues [active] 439855013545 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 439855013546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855013547 Transposase; Region: HTH_Tnp_1; cl17663 439855013548 HTH-like domain; Region: HTH_21; pfam13276 439855013549 Integrase core domain; Region: rve; pfam00665 439855013550 DDE domain; Region: DDE_Tnp_IS240; pfam13610 439855013551 Integrase core domain; Region: rve_3; pfam13683 439855013552 homoserine O-succinyltransferase; Provisional; Region: PRK05368 439855013553 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 439855013554 proposed active site lysine [active] 439855013555 conserved cys residue [active] 439855013556 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 439855013557 malate synthase A; Region: malate_syn_A; TIGR01344 439855013558 active site 439855013559 isocitrate lyase; Provisional; Region: PRK15063 439855013560 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 439855013561 tetramer interface [polypeptide binding]; other site 439855013562 active site 439855013563 Mg2+/Mn2+ binding site [ion binding]; other site 439855013564 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 439855013565 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 439855013566 transcriptional repressor IclR; Provisional; Region: PRK11569 439855013567 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 439855013568 Bacterial transcriptional regulator; Region: IclR; pfam01614 439855013569 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 439855013570 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 439855013571 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 439855013572 substrate binding pocket [chemical binding]; other site 439855013573 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 439855013574 B12 binding site [chemical binding]; other site 439855013575 cobalt ligand [ion binding]; other site 439855013576 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 439855013577 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 439855013578 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 439855013579 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 439855013580 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 439855013581 active site pocket [active] 439855013582 oxyanion hole [active] 439855013583 catalytic triad [active] 439855013584 active site nucleophile [active] 439855013585 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 439855013586 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 439855013587 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 439855013588 shikimate binding site; other site 439855013589 NAD(P) binding site [chemical binding]; other site 439855013590 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 439855013591 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855013592 putative NAD(P) binding site [chemical binding]; other site 439855013593 catalytic Zn binding site [ion binding]; other site 439855013594 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 439855013595 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 439855013596 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 439855013597 active site 439855013598 phosphorylation site [posttranslational modification] 439855013599 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 439855013600 active pocket/dimerization site; other site 439855013601 active site 439855013602 phosphorylation site [posttranslational modification] 439855013603 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 439855013604 classical (c) SDRs; Region: SDR_c; cd05233 439855013605 NAD(P) binding site [chemical binding]; other site 439855013606 active site 439855013607 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 439855013608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 439855013609 putative DNA binding site [nucleotide binding]; other site 439855013610 putative Zn2+ binding site [ion binding]; other site 439855013611 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 439855013612 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 439855013613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 439855013614 RNA binding surface [nucleotide binding]; other site 439855013615 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 439855013616 probable active site [active] 439855013617 hypothetical protein; Provisional; Region: PRK10515 439855013618 aspartate kinase III; Validated; Region: PRK09084 439855013619 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 439855013620 nucleotide binding site [chemical binding]; other site 439855013621 substrate binding site [chemical binding]; other site 439855013622 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 439855013623 lysine allosteric regulatory site; other site 439855013624 dimer interface [polypeptide binding]; other site 439855013625 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 439855013626 dimer interface [polypeptide binding]; other site 439855013627 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 439855013628 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 439855013629 active site 439855013630 dimer interface [polypeptide binding]; other site 439855013631 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 439855013632 dimer interface [polypeptide binding]; other site 439855013633 active site 439855013634 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 439855013635 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 439855013636 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 439855013637 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 439855013638 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 439855013639 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 439855013640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855013641 dimer interface [polypeptide binding]; other site 439855013642 conserved gate region; other site 439855013643 putative PBP binding loops; other site 439855013644 ABC-ATPase subunit interface; other site 439855013645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855013646 dimer interface [polypeptide binding]; other site 439855013647 conserved gate region; other site 439855013648 putative PBP binding loops; other site 439855013649 ABC-ATPase subunit interface; other site 439855013650 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 439855013651 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 439855013652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 439855013653 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 439855013654 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 439855013655 Walker A/P-loop; other site 439855013656 ATP binding site [chemical binding]; other site 439855013657 Q-loop/lid; other site 439855013658 ABC transporter signature motif; other site 439855013659 Walker B; other site 439855013660 D-loop; other site 439855013661 H-loop/switch region; other site 439855013662 TOBE domain; Region: TOBE_2; pfam08402 439855013663 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 439855013664 trimer interface; other site 439855013665 sugar binding site [chemical binding]; other site 439855013666 maltose regulon periplasmic protein; Provisional; Region: PRK10564 439855013667 hypothetical protein; Validated; Region: PRK09718 439855013668 SopA-like central domain; Region: SopA; pfam13981 439855013669 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 439855013670 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 439855013671 UbiA prenyltransferase family; Region: UbiA; pfam01040 439855013672 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 439855013673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 439855013674 putative acyl-acceptor binding pocket; other site 439855013675 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 439855013676 LexA repressor; Validated; Region: PRK00215 439855013677 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 439855013678 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 439855013679 Catalytic site [active] 439855013680 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 439855013681 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 439855013682 hypothetical protein; Provisional; Region: PRK10428 439855013683 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 439855013684 metal binding site 2 [ion binding]; metal-binding site 439855013685 putative DNA binding helix; other site 439855013686 metal binding site 1 [ion binding]; metal-binding site 439855013687 dimer interface [polypeptide binding]; other site 439855013688 structural Zn2+ binding site [ion binding]; other site 439855013689 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 439855013690 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 439855013691 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 439855013692 FMN binding site [chemical binding]; other site 439855013693 active site 439855013694 catalytic residues [active] 439855013695 substrate binding site [chemical binding]; other site 439855013696 phage shock protein G; Reviewed; Region: pspG; PRK09459 439855013697 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 439855013698 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 439855013699 NADP binding site [chemical binding]; other site 439855013700 dimer interface [polypeptide binding]; other site 439855013701 replicative DNA helicase; Provisional; Region: PRK08006 439855013702 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 439855013703 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 439855013704 Walker A motif; other site 439855013705 ATP binding site [chemical binding]; other site 439855013706 Walker B motif; other site 439855013707 DNA binding loops [nucleotide binding] 439855013708 alanine racemase; Reviewed; Region: alr; PRK00053 439855013709 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 439855013710 active site 439855013711 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855013712 substrate binding site [chemical binding]; other site 439855013713 catalytic residues [active] 439855013714 dimer interface [polypeptide binding]; other site 439855013715 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 439855013716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855013717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855013718 homodimer interface [polypeptide binding]; other site 439855013719 catalytic residue [active] 439855013720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855013721 active site 439855013722 motif I; other site 439855013723 motif II; other site 439855013724 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 439855013725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 439855013726 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 439855013727 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 439855013728 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 439855013729 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 439855013730 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 439855013731 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 439855013732 dimer interface [polypeptide binding]; other site 439855013733 ssDNA binding site [nucleotide binding]; other site 439855013734 tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855013735 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 439855013736 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 439855013737 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 439855013738 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 439855013739 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 439855013740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013741 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 439855013742 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 439855013743 DNA binding residues [nucleotide binding] 439855013744 dimer interface [polypeptide binding]; other site 439855013745 [2Fe-2S] cluster binding site [ion binding]; other site 439855013746 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 439855013747 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 439855013748 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 439855013749 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 439855013750 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 439855013751 Na binding site [ion binding]; other site 439855013752 Predicted membrane protein [Function unknown]; Region: COG3162 439855013753 acetyl-CoA synthetase; Provisional; Region: PRK00174 439855013754 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 439855013755 active site 439855013756 CoA binding site [chemical binding]; other site 439855013757 acyl-activating enzyme (AAE) consensus motif; other site 439855013758 AMP binding site [chemical binding]; other site 439855013759 acetate binding site [chemical binding]; other site 439855013760 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 439855013761 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 439855013762 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 439855013763 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 439855013764 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 439855013765 heme lyase subunit NrfE; Provisional; Region: PRK10369 439855013766 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 439855013767 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 439855013768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 439855013769 binding surface 439855013770 TPR motif; other site 439855013771 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 439855013772 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 439855013773 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 439855013774 Sel1-like repeats; Region: SEL1; smart00671 439855013775 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 439855013776 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 439855013777 [4Fe-4S] binding site [ion binding]; other site 439855013778 molybdopterin cofactor binding site; other site 439855013779 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 439855013780 molybdopterin cofactor binding site; other site 439855013781 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 439855013782 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 439855013783 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 439855013784 multidrug resistance protein MdtN; Provisional; Region: PRK10476 439855013785 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 439855013786 HlyD family secretion protein; Region: HlyD_3; pfam13437 439855013787 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 439855013788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 439855013789 D-allose kinase; Provisional; Region: PRK09698 439855013790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 439855013791 nucleotide binding site [chemical binding]; other site 439855013792 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 439855013793 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 439855013794 substrate binding site [chemical binding]; other site 439855013795 hexamer interface [polypeptide binding]; other site 439855013796 metal binding site [ion binding]; metal-binding site 439855013797 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855013798 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855013799 TM-ABC transporter signature motif; other site 439855013800 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 439855013801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855013802 Walker A/P-loop; other site 439855013803 ATP binding site [chemical binding]; other site 439855013804 Q-loop/lid; other site 439855013805 ABC transporter signature motif; other site 439855013806 Walker B; other site 439855013807 D-loop; other site 439855013808 H-loop/switch region; other site 439855013809 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855013810 D-allose transporter subunit; Provisional; Region: PRK09701 439855013811 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 439855013812 ligand binding site [chemical binding]; other site 439855013813 dimerization interface [polypeptide binding]; other site 439855013814 zinc binding site [ion binding]; other site 439855013815 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 439855013816 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 439855013817 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 439855013818 putative active site [active] 439855013819 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 439855013820 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 439855013821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855013822 Coenzyme A binding pocket [chemical binding]; other site 439855013823 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 439855013824 AAA domain; Region: AAA_18; pfam13238 439855013825 active site 439855013826 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 439855013827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 439855013828 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 439855013829 active site 439855013830 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 439855013831 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 439855013832 Walker A/P-loop; other site 439855013833 ATP binding site [chemical binding]; other site 439855013834 Q-loop/lid; other site 439855013835 ABC transporter signature motif; other site 439855013836 Walker B; other site 439855013837 D-loop; other site 439855013838 H-loop/switch region; other site 439855013839 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 439855013840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 439855013841 Walker A/P-loop; other site 439855013842 ATP binding site [chemical binding]; other site 439855013843 Q-loop/lid; other site 439855013844 ABC transporter signature motif; other site 439855013845 Walker B; other site 439855013846 D-loop; other site 439855013847 H-loop/switch region; other site 439855013848 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 439855013849 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 439855013850 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 439855013851 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 439855013852 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 439855013853 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 439855013854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855013855 DNA-binding site [nucleotide binding]; DNA binding site 439855013856 UTRA domain; Region: UTRA; pfam07702 439855013857 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 439855013858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 439855013859 dimer interface [polypeptide binding]; other site 439855013860 conserved gate region; other site 439855013861 putative PBP binding loops; other site 439855013862 ABC-ATPase subunit interface; other site 439855013863 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 439855013864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 439855013865 substrate binding pocket [chemical binding]; other site 439855013866 membrane-bound complex binding site; other site 439855013867 hinge residues; other site 439855013868 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 439855013869 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 439855013870 Walker A/P-loop; other site 439855013871 ATP binding site [chemical binding]; other site 439855013872 Q-loop/lid; other site 439855013873 ABC transporter signature motif; other site 439855013874 Walker B; other site 439855013875 D-loop; other site 439855013876 H-loop/switch region; other site 439855013877 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 439855013878 dimer interface [polypeptide binding]; other site 439855013879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 439855013880 hypothetical protein; Provisional; Region: PRK10220 439855013881 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 439855013882 PhnA protein; Region: PhnA; pfam03831 439855013883 hypothetical protein; Provisional; Region: PRK09866 439855013884 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 439855013885 G1 box; other site 439855013886 GTP/Mg2+ binding site [chemical binding]; other site 439855013887 G2 box; other site 439855013888 Switch I region; other site 439855013889 G3 box; other site 439855013890 Switch II region; other site 439855013891 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 439855013892 G2 box; other site 439855013893 Switch I region; other site 439855013894 G3 box; other site 439855013895 Switch II region; other site 439855013896 G4 box; other site 439855013897 G5 box; other site 439855013898 YjcZ-like protein; Region: YjcZ; pfam13990 439855013899 proline/glycine betaine transporter; Provisional; Region: PRK10642 439855013900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855013901 putative substrate translocation pore; other site 439855013902 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 439855013903 sensor protein BasS/PmrB; Provisional; Region: PRK10755 439855013904 HAMP domain; Region: HAMP; pfam00672 439855013905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855013906 dimer interface [polypeptide binding]; other site 439855013907 phosphorylation site [posttranslational modification] 439855013908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855013909 ATP binding site [chemical binding]; other site 439855013910 Mg2+ binding site [ion binding]; other site 439855013911 G-X-G motif; other site 439855013912 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 439855013913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855013914 active site 439855013915 phosphorylation site [posttranslational modification] 439855013916 intermolecular recognition site; other site 439855013917 dimerization interface [polypeptide binding]; other site 439855013918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855013919 DNA binding site [nucleotide binding] 439855013920 putative metal dependent hydrolase; Provisional; Region: PRK11598 439855013921 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 439855013922 Sulfatase; Region: Sulfatase; pfam00884 439855013923 arginine:agmatin antiporter; Provisional; Region: PRK10644 439855013924 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 439855013925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013926 arginine decarboxylase; Provisional; Region: PRK15029 439855013927 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 439855013928 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 439855013929 homodimer interface [polypeptide binding]; other site 439855013930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855013931 catalytic residue [active] 439855013932 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 439855013933 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 439855013934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855013936 alpha-galactosidase; Provisional; Region: PRK15076 439855013937 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 439855013938 NAD binding site [chemical binding]; other site 439855013939 sugar binding site [chemical binding]; other site 439855013940 divalent metal binding site [ion binding]; other site 439855013941 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 439855013942 dimer interface [polypeptide binding]; other site 439855013943 melibiose:sodium symporter; Provisional; Region: PRK10429 439855013944 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 439855013945 hypothetical protein; Provisional; Region: PRK09867 439855013946 fumarate hydratase; Provisional; Region: PRK15389 439855013947 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 439855013948 Fumarase C-terminus; Region: Fumerase_C; pfam05683 439855013949 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 439855013950 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 439855013951 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 439855013952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855013953 active site 439855013954 phosphorylation site [posttranslational modification] 439855013955 intermolecular recognition site; other site 439855013956 dimerization interface [polypeptide binding]; other site 439855013957 Transcriptional regulator; Region: CitT; pfam12431 439855013958 sensory histidine kinase DcuS; Provisional; Region: PRK11086 439855013959 PAS domain; Region: PAS; smart00091 439855013960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855013961 ATP binding site [chemical binding]; other site 439855013962 Mg2+ binding site [ion binding]; other site 439855013963 G-X-G motif; other site 439855013964 Uncharacterized conserved protein [Function unknown]; Region: COG3592 439855013965 Predicted acetyltransferase [General function prediction only]; Region: COG2388 439855013966 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 439855013967 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 439855013968 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 439855013969 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 439855013970 dimer interface [polypeptide binding]; other site 439855013971 putative anticodon binding site; other site 439855013972 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 439855013973 motif 1; other site 439855013974 active site 439855013975 motif 2; other site 439855013976 motif 3; other site 439855013977 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 439855013978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855013979 putative substrate translocation pore; other site 439855013980 POT family; Region: PTR2; pfam00854 439855013981 lysine decarboxylase CadA; Provisional; Region: PRK15400 439855013982 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 439855013983 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 439855013984 homodimer interface [polypeptide binding]; other site 439855013985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855013986 catalytic residue [active] 439855013987 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 439855013988 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 439855013989 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 439855013990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855013991 DNA binding site [nucleotide binding] 439855013992 putative transcriptional regulator; Provisional; Region: PRK11640 439855013993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855013994 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 439855013995 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 439855013996 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 439855013997 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 439855013998 DsbD alpha interface [polypeptide binding]; other site 439855013999 catalytic residues [active] 439855014000 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 439855014001 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 439855014002 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 439855014003 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 439855014004 Aspartase; Region: Aspartase; cd01357 439855014005 active sites [active] 439855014006 tetramer interface [polypeptide binding]; other site 439855014007 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 439855014008 putative transporter; Provisional; Region: PRK11021 439855014009 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 439855014010 oligomerisation interface [polypeptide binding]; other site 439855014011 mobile loop; other site 439855014012 roof hairpin; other site 439855014013 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 439855014014 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 439855014015 ring oligomerisation interface [polypeptide binding]; other site 439855014016 ATP/Mg binding site [chemical binding]; other site 439855014017 stacking interactions; other site 439855014018 hinge regions; other site 439855014019 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 439855014020 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 439855014021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855014022 FeS/SAM binding site; other site 439855014023 elongation factor P; Validated; Region: PRK00529 439855014024 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 439855014025 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 439855014026 RNA binding site [nucleotide binding]; other site 439855014027 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 439855014028 RNA binding site [nucleotide binding]; other site 439855014029 entericidin A; Provisional; Region: PRK09810 439855014030 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 439855014031 multidrug efflux system protein; Provisional; Region: PRK11431 439855014032 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 439855014033 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 439855014034 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 439855014035 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 439855014036 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 439855014037 Iron-sulfur protein interface; other site 439855014038 proximal quinone binding site [chemical binding]; other site 439855014039 C-subunit interface; other site 439855014040 distal quinone binding site; other site 439855014041 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 439855014042 D-subunit interface [polypeptide binding]; other site 439855014043 Iron-sulfur protein interface; other site 439855014044 proximal quinone binding site [chemical binding]; other site 439855014045 distal quinone binding site [chemical binding]; other site 439855014046 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 439855014047 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 439855014048 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 439855014049 L-aspartate oxidase; Provisional; Region: PRK06175 439855014050 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 439855014051 poxB regulator PoxA; Provisional; Region: PRK09350 439855014052 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 439855014053 motif 1; other site 439855014054 dimer interface [polypeptide binding]; other site 439855014055 active site 439855014056 motif 2; other site 439855014057 motif 3; other site 439855014058 inner membrane transporter YjeM; Provisional; Region: PRK15238 439855014059 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 439855014060 putative mechanosensitive channel protein; Provisional; Region: PRK10929 439855014061 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 439855014062 DNA-binding site [nucleotide binding]; DNA binding site 439855014063 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 439855014064 Mechanosensitive ion channel; Region: MS_channel; pfam00924 439855014065 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 439855014066 GTPase RsgA; Reviewed; Region: PRK12288 439855014067 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 439855014068 RNA binding site [nucleotide binding]; other site 439855014069 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 439855014070 GTPase/Zn-binding domain interface [polypeptide binding]; other site 439855014071 GTP/Mg2+ binding site [chemical binding]; other site 439855014072 G4 box; other site 439855014073 G5 box; other site 439855014074 G1 box; other site 439855014075 Switch I region; other site 439855014076 G2 box; other site 439855014077 G3 box; other site 439855014078 Switch II region; other site 439855014079 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 439855014080 catalytic site [active] 439855014081 putative active site [active] 439855014082 putative substrate binding site [chemical binding]; other site 439855014083 dimer interface [polypeptide binding]; other site 439855014084 epoxyqueuosine reductase; Region: TIGR00276 439855014085 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 439855014086 putative carbohydrate kinase; Provisional; Region: PRK10565 439855014087 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 439855014088 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 439855014089 putative substrate binding site [chemical binding]; other site 439855014090 putative ATP binding site [chemical binding]; other site 439855014091 ADP-binding protein; Provisional; Region: PRK10646 439855014092 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 439855014093 AMIN domain; Region: AMIN; pfam11741 439855014094 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 439855014095 active site 439855014096 metal binding site [ion binding]; metal-binding site 439855014097 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 439855014098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855014099 ATP binding site [chemical binding]; other site 439855014100 Mg2+ binding site [ion binding]; other site 439855014101 G-X-G motif; other site 439855014102 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 439855014103 ATP binding site [chemical binding]; other site 439855014104 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 439855014105 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 439855014106 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 439855014107 bacterial Hfq-like; Region: Hfq; cd01716 439855014108 hexamer interface [polypeptide binding]; other site 439855014109 Sm1 motif; other site 439855014110 RNA binding site [nucleotide binding]; other site 439855014111 Sm2 motif; other site 439855014112 GTPase HflX; Provisional; Region: PRK11058 439855014113 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 439855014114 HflX GTPase family; Region: HflX; cd01878 439855014115 G1 box; other site 439855014116 GTP/Mg2+ binding site [chemical binding]; other site 439855014117 Switch I region; other site 439855014118 G2 box; other site 439855014119 G3 box; other site 439855014120 Switch II region; other site 439855014121 G4 box; other site 439855014122 G5 box; other site 439855014123 FtsH protease regulator HflK; Provisional; Region: PRK10930 439855014124 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 439855014125 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 439855014126 FtsH protease regulator HflC; Provisional; Region: PRK11029 439855014127 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 439855014128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 439855014129 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 439855014130 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 439855014131 GDP-binding site [chemical binding]; other site 439855014132 ACT binding site; other site 439855014133 IMP binding site; other site 439855014134 Predicted transcriptional regulator [Transcription]; Region: COG1959 439855014135 transcriptional repressor NsrR; Provisional; Region: PRK11014 439855014136 exoribonuclease R; Provisional; Region: PRK11642 439855014137 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 439855014138 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 439855014139 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 439855014140 RNB domain; Region: RNB; pfam00773 439855014141 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 439855014142 RNA binding site [nucleotide binding]; other site 439855014143 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 439855014144 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 439855014145 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 439855014146 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 439855014147 PspA/IM30 family; Region: PspA_IM30; pfam04012 439855014148 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 439855014149 Predicted membrane protein [Function unknown]; Region: COG3766 439855014150 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 439855014151 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 439855014152 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 439855014153 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 439855014154 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 439855014155 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 439855014156 FAD binding site [chemical binding]; other site 439855014157 substrate binding site [chemical binding]; other site 439855014158 catalytic residues [active] 439855014159 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855014160 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 439855014161 esterase; Provisional; Region: PRK10566 439855014162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 439855014163 transcriptional repressor UlaR; Provisional; Region: PRK13509 439855014164 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 439855014165 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 439855014166 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 439855014167 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 439855014168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 439855014169 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 439855014170 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 439855014171 active site 439855014172 P-loop; other site 439855014173 phosphorylation site [posttranslational modification] 439855014174 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 439855014175 active site 439855014176 phosphorylation site [posttranslational modification] 439855014177 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 439855014178 active site 439855014179 dimer interface [polypeptide binding]; other site 439855014180 magnesium binding site [ion binding]; other site 439855014181 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 439855014182 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 439855014183 AP (apurinic/apyrimidinic) site pocket; other site 439855014184 DNA interaction; other site 439855014185 Metal-binding active site; metal-binding site 439855014186 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 439855014187 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 439855014188 intersubunit interface [polypeptide binding]; other site 439855014189 active site 439855014190 Zn2+ binding site [ion binding]; other site 439855014191 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 439855014192 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 439855014193 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 439855014194 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 439855014195 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 439855014196 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 439855014197 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 439855014198 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 439855014199 DctM-like transporters; Region: DctM; pfam06808 439855014200 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 439855014201 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 439855014202 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 439855014203 L-aspartate oxidase; Provisional; Region: PRK06175 439855014204 L-aspartate oxidase; Provisional; Region: PRK06175 439855014205 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 439855014206 Coenzyme A transferase; Region: CoA_trans; smart00882 439855014207 Coenzyme A transferase; Region: CoA_trans; cl17247 439855014208 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 439855014209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 439855014210 substrate binding site [chemical binding]; other site 439855014211 oxyanion hole (OAH) forming residues; other site 439855014212 trimer interface [polypeptide binding]; other site 439855014213 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 439855014214 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 439855014215 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 439855014216 putative NAD(P) binding site [chemical binding]; other site 439855014217 active site 439855014218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 439855014219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855014220 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 439855014221 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 439855014222 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 439855014223 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 439855014224 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 439855014225 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 439855014226 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 439855014227 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 439855014228 Hemerythrin-like domain; Region: Hr-like; cd12108 439855014229 Fe binding site [ion binding]; other site 439855014230 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 439855014231 EamA-like transporter family; Region: EamA; pfam00892 439855014232 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 439855014233 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 439855014234 NADP binding site [chemical binding]; other site 439855014235 Predicted transcriptional regulators [Transcription]; Region: COG1733 439855014236 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 439855014237 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 439855014238 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 439855014239 active site 439855014240 metal binding site [ion binding]; metal-binding site 439855014241 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 439855014242 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 439855014243 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 439855014244 active site 439855014245 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 439855014246 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 439855014247 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 439855014248 Domain of unknown function DUF21; Region: DUF21; pfam01595 439855014249 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 439855014250 Transporter associated domain; Region: CorC_HlyC; smart01091 439855014251 methionine sulfoxide reductase A; Provisional; Region: PRK00058 439855014252 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 439855014253 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 439855014254 Surface antigen; Region: Bac_surface_Ag; pfam01103 439855014255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 439855014256 Family of unknown function (DUF490); Region: DUF490; pfam04357 439855014257 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 439855014258 putative active site pocket [active] 439855014259 dimerization interface [polypeptide binding]; other site 439855014260 putative catalytic residue [active] 439855014261 antitoxin ChpS; Provisional; Region: PRK11347 439855014262 toxin ChpB; Provisional; Region: PRK09812 439855014263 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 439855014264 dimer interface [polypeptide binding]; other site 439855014265 substrate binding site [chemical binding]; other site 439855014266 metal binding sites [ion binding]; metal-binding site 439855014267 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 439855014268 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 439855014269 putative ligand binding site [chemical binding]; other site 439855014270 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 439855014271 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 439855014272 Walker A/P-loop; other site 439855014273 ATP binding site [chemical binding]; other site 439855014274 Q-loop/lid; other site 439855014275 ABC transporter signature motif; other site 439855014276 Walker B; other site 439855014277 D-loop; other site 439855014278 H-loop/switch region; other site 439855014279 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 439855014280 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855014281 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855014282 TM-ABC transporter signature motif; other site 439855014283 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 439855014284 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 439855014285 TM-ABC transporter signature motif; other site 439855014286 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 439855014287 AMP binding site [chemical binding]; other site 439855014288 metal binding site [ion binding]; metal-binding site 439855014289 active site 439855014290 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 439855014291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 439855014292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 439855014293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 439855014294 hypothetical protein; Provisional; Region: PRK05255 439855014295 peptidase PmbA; Provisional; Region: PRK11040 439855014296 cytochrome b562; Provisional; Region: PRK15058 439855014297 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 439855014298 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 439855014299 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 439855014300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855014301 FeS/SAM binding site; other site 439855014302 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 439855014303 ATP cone domain; Region: ATP-cone; pfam03477 439855014304 Class III ribonucleotide reductase; Region: RNR_III; cd01675 439855014305 effector binding site; other site 439855014306 active site 439855014307 Zn binding site [ion binding]; other site 439855014308 glycine loop; other site 439855014309 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 439855014310 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 439855014311 Ca binding site [ion binding]; other site 439855014312 active site 439855014313 catalytic site [active] 439855014314 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 439855014315 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 439855014316 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 439855014317 active site turn [active] 439855014318 phosphorylation site [posttranslational modification] 439855014319 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 439855014320 trehalose repressor; Provisional; Region: treR; PRK09492 439855014321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855014322 DNA binding site [nucleotide binding] 439855014323 domain linker motif; other site 439855014324 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 439855014325 dimerization interface [polypeptide binding]; other site 439855014326 ligand binding site [chemical binding]; other site 439855014327 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 439855014328 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 439855014329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 439855014330 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 439855014331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855014332 motif II; other site 439855014333 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 439855014334 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 439855014335 homotrimer interaction site [polypeptide binding]; other site 439855014336 putative active site [active] 439855014337 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 439855014338 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 439855014339 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 439855014340 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 439855014341 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 439855014342 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 439855014343 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 439855014344 homotrimer interaction site [polypeptide binding]; other site 439855014345 putative active site [active] 439855014346 oxidoreductase; Provisional; Region: PRK12742 439855014347 classical (c) SDRs; Region: SDR_c; cd05233 439855014348 NAD(P) binding site [chemical binding]; other site 439855014349 active site 439855014350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 439855014351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 439855014352 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 439855014353 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 439855014354 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 439855014355 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 439855014356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 439855014357 RNase E inhibitor protein; Provisional; Region: PRK11191 439855014358 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 439855014359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855014360 Coenzyme A binding pocket [chemical binding]; other site 439855014361 Predicted membrane protein [Function unknown]; Region: COG4269 439855014362 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 439855014363 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 439855014364 HIGH motif; other site 439855014365 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 439855014366 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 439855014367 active site 439855014368 KMSKS motif; other site 439855014369 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 439855014370 tRNA binding surface [nucleotide binding]; other site 439855014371 anticodon binding site; other site 439855014372 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 439855014373 DNA polymerase III subunit chi; Validated; Region: PRK05728 439855014374 multifunctional aminopeptidase A; Provisional; Region: PRK00913 439855014375 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 439855014376 interface (dimer of trimers) [polypeptide binding]; other site 439855014377 Substrate-binding/catalytic site; other site 439855014378 Zn-binding sites [ion binding]; other site 439855014379 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 439855014380 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 439855014381 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 439855014382 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 439855014383 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 439855014384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 439855014385 Walker A motif; other site 439855014386 ATP binding site [chemical binding]; other site 439855014387 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 439855014388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 439855014389 DNA binding site [nucleotide binding] 439855014390 domain linker motif; other site 439855014391 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 439855014392 putative dimerization interface [polypeptide binding]; other site 439855014393 putative ligand binding site [chemical binding]; other site 439855014394 fructuronate transporter; Provisional; Region: PRK10034; cl15264 439855014395 gluconate transporter; Region: gntP; TIGR00791 439855014396 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 439855014397 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 439855014398 NADP binding site [chemical binding]; other site 439855014399 homodimer interface [polypeptide binding]; other site 439855014400 active site 439855014401 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 439855014402 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 439855014403 putative NAD(P) binding site [chemical binding]; other site 439855014404 catalytic Zn binding site [ion binding]; other site 439855014405 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 439855014406 ATP-binding site [chemical binding]; other site 439855014407 Gluconate-6-phosphate binding site [chemical binding]; other site 439855014408 Shikimate kinase; Region: SKI; pfam01202 439855014409 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 439855014410 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 439855014411 putative NAD(P) binding site [chemical binding]; other site 439855014412 putative substrate binding site [chemical binding]; other site 439855014413 catalytic Zn binding site [ion binding]; other site 439855014414 structural Zn binding site [ion binding]; other site 439855014415 dimer interface [polypeptide binding]; other site 439855014416 integrase; Provisional; Region: PRK09692 439855014417 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 439855014418 active site 439855014419 Int/Topo IB signature motif; other site 439855014420 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 439855014421 Sulfatase; Region: Sulfatase; cl17466 439855014422 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 439855014423 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 439855014424 RelB antitoxin; Region: RelB; cl01171 439855014425 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 439855014426 HsdM N-terminal domain; Region: HsdM_N; pfam12161 439855014427 Methyltransferase domain; Region: Methyltransf_26; pfam13659 439855014428 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 439855014429 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 439855014430 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 439855014431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855014432 ATP binding site [chemical binding]; other site 439855014433 putative Mg++ binding site [ion binding]; other site 439855014434 Virulence protein [General function prediction only]; Region: COG3943 439855014435 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 439855014436 putative transposase OrfB; Reviewed; Region: PHA02517 439855014437 HTH-like domain; Region: HTH_21; pfam13276 439855014438 Integrase core domain; Region: rve; pfam00665 439855014439 Integrase core domain; Region: rve_3; pfam13683 439855014440 Transposase; Region: HTH_Tnp_1; cl17663 439855014441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 439855014442 HTH-like domain; Region: HTH_21; pfam13276 439855014443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 439855014444 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 439855014445 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 439855014446 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 439855014447 H-NS histone family; Region: Histone_HNS; pfam00816 439855014448 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 439855014449 Restriction endonuclease; Region: Mrr_cat; pfam04471 439855014450 Transposase; Region: HTH_Tnp_1; cl17663 439855014451 putative transposase OrfB; Reviewed; Region: PHA02517 439855014452 HTH-like domain; Region: HTH_21; pfam13276 439855014453 Integrase core domain; Region: rve; pfam00665 439855014454 Integrase core domain; Region: rve_3; pfam13683 439855014455 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 439855014456 Predicted GTPase [General function prediction only]; Region: COG3596 439855014457 YfjP GTPase; Region: YfjP; cd11383 439855014458 G1 box; other site 439855014459 GTP/Mg2+ binding site [chemical binding]; other site 439855014460 Switch I region; other site 439855014461 G2 box; other site 439855014462 Switch II region; other site 439855014463 G3 box; other site 439855014464 G4 box; other site 439855014465 G5 box; other site 439855014466 HTH domain; Region: HTH_11; cl17392 439855014467 WYL domain; Region: WYL; pfam13280 439855014468 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 439855014469 Domain of unknown function (DUF932); Region: DUF932; pfam06067 439855014470 Antirestriction protein; Region: Antirestrict; pfam03230 439855014471 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 439855014472 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 439855014473 MPN+ (JAMM) motif; other site 439855014474 Zinc-binding site [ion binding]; other site 439855014475 Protein of unknown function (DUF987); Region: DUF987; pfam06174 439855014476 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 439855014477 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 439855014478 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 439855014479 Predicted transcriptional regulator [Transcription]; Region: COG2378 439855014480 WYL domain; Region: WYL; pfam13280 439855014481 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 439855014482 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 439855014483 Protein of unknown function DUF91; Region: DUF91; cl00709 439855014484 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 439855014485 HNH endonuclease; Region: HNH_2; pfam13391 439855014486 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 439855014487 active site 439855014488 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 439855014489 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 439855014490 active site 439855014491 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 439855014492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 439855014493 ligand binding site [chemical binding]; other site 439855014494 Capsid triplex subunit 2; Provisional; Region: PHA03259 439855014495 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 439855014496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855014497 ATP binding site [chemical binding]; other site 439855014498 putative Mg++ binding site [ion binding]; other site 439855014499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855014500 nucleotide binding region [chemical binding]; other site 439855014501 ATP-binding site [chemical binding]; other site 439855014502 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 439855014503 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 439855014504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855014505 ATP binding site [chemical binding]; other site 439855014506 putative Mg++ binding site [ion binding]; other site 439855014507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855014508 nucleotide binding region [chemical binding]; other site 439855014509 ATP-binding site [chemical binding]; other site 439855014510 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 439855014511 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 439855014512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 439855014513 ATP binding site [chemical binding]; other site 439855014514 putative Mg++ binding site [ion binding]; other site 439855014515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 439855014516 ATP-binding site [chemical binding]; other site 439855014517 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 439855014518 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 439855014519 Part of AAA domain; Region: AAA_19; pfam13245 439855014520 Family description; Region: UvrD_C_2; pfam13538 439855014521 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 439855014522 Domain of unknown function (DUF303); Region: DUF303; pfam03629 439855014523 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 439855014524 Kelch motif; Region: Kelch_1; pfam01344 439855014525 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 439855014526 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 439855014527 Int/Topo IB signature motif; other site 439855014528 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 439855014529 Int/Topo IB signature motif; other site 439855014530 Fimbrial protein; Region: Fimbrial; cl01416 439855014531 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855014532 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 439855014533 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 439855014534 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 439855014535 outer membrane usher protein; Provisional; Region: PRK15193 439855014536 PapC N-terminal domain; Region: PapC_N; pfam13954 439855014537 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 439855014538 PapC C-terminal domain; Region: PapC_C; pfam13953 439855014539 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855014540 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 439855014541 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 439855014542 mannosyl binding site [chemical binding]; other site 439855014543 Fimbrial protein; Region: Fimbrial; pfam00419 439855014544 fructuronate transporter; Provisional; Region: PRK10034 439855014545 gluconate transporter; Region: gntP; TIGR00791 439855014546 mannonate dehydratase; Region: uxuA; TIGR00695 439855014547 mannonate dehydratase; Provisional; Region: PRK03906 439855014548 D-mannonate oxidoreductase; Provisional; Region: PRK15037 439855014549 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 439855014550 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 439855014551 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 439855014552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855014553 DNA-binding site [nucleotide binding]; DNA binding site 439855014554 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855014555 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 439855014556 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 439855014557 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 439855014558 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 439855014559 active pocket/dimerization site; other site 439855014560 active site 439855014561 phosphorylation site [posttranslational modification] 439855014562 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 439855014563 dimerization domain swap beta strand [polypeptide binding]; other site 439855014564 regulatory protein interface [polypeptide binding]; other site 439855014565 active site 439855014566 regulatory phosphorylation site [posttranslational modification]; other site 439855014567 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 439855014568 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 439855014569 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 439855014570 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 439855014571 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 439855014572 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 439855014573 Dak1 domain; Region: Dak1; pfam02733 439855014574 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 439855014575 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 439855014576 dimer interface [polypeptide binding]; other site 439855014577 active site 439855014578 metal binding site [ion binding]; metal-binding site 439855014579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855014580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855014581 putative substrate translocation pore; other site 439855014582 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 439855014583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 439855014584 BCCT family transporter; Region: BCCT; pfam02028 439855014585 glycerate kinase; Region: TIGR00045 439855014586 tartronate semialdehyde reductase; Provisional; Region: PRK15059 439855014587 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 439855014588 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 439855014589 glyoxylate carboligase; Provisional; Region: PRK11269 439855014590 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 439855014591 PYR/PP interface [polypeptide binding]; other site 439855014592 dimer interface [polypeptide binding]; other site 439855014593 TPP binding site [chemical binding]; other site 439855014594 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 439855014595 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 439855014596 TPP-binding site [chemical binding]; other site 439855014597 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 439855014598 GAF domain; Region: GAF; pfam01590 439855014599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 439855014600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855014601 Walker A motif; other site 439855014602 ATP binding site [chemical binding]; other site 439855014603 Walker B motif; other site 439855014604 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 439855014605 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 439855014606 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 439855014607 cell density-dependent motility repressor; Provisional; Region: PRK10082 439855014608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 439855014609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 439855014610 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 439855014611 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 439855014612 dimer interface [polypeptide binding]; other site 439855014613 active site 439855014614 hypothetical protein; Provisional; Region: PRK10519 439855014615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 439855014616 Nucleoside recognition; Region: Gate; pfam07670 439855014617 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 439855014618 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 439855014619 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 439855014620 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014621 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014622 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014623 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014624 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014625 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014626 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014627 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 439855014628 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 439855014629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 439855014630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855014631 putative substrate translocation pore; other site 439855014632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 439855014633 SdiA-regulated; Region: SdiA-regulated; cd09971 439855014634 putative active site [active] 439855014635 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 439855014636 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 439855014637 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 439855014638 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 439855014639 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 439855014640 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 439855014641 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 439855014642 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 439855014643 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 439855014644 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 439855014645 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 439855014646 Predicted membrane protein [Function unknown]; Region: COG2733 439855014647 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 439855014648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855014649 putative substrate translocation pore; other site 439855014650 putative transposase; Provisional; Region: PRK09857 439855014651 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 439855014652 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 439855014653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855014654 DNA-binding site [nucleotide binding]; DNA binding site 439855014655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 439855014656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 439855014657 homodimer interface [polypeptide binding]; other site 439855014658 catalytic residue [active] 439855014659 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 439855014660 Uncharacterized conserved protein [Function unknown]; Region: COG1479 439855014661 Protein of unknown function DUF262; Region: DUF262; pfam03235 439855014662 Protein of unknown function DUF262; Region: DUF262; pfam03235 439855014663 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 439855014664 Uncharacterized conserved protein [Function unknown]; Region: COG3586 439855014665 endoribonuclease SymE; Provisional; Region: PRK13605 439855014666 Nuclease-related domain; Region: NERD; pfam08378 439855014667 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 439855014668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 439855014669 ATP binding site [chemical binding]; other site 439855014670 putative Mg++ binding site [ion binding]; other site 439855014671 Family description; Region: UvrD_C_2; pfam13538 439855014672 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 439855014673 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 439855014674 P-loop, Walker A motif; other site 439855014675 Base recognition motif; other site 439855014676 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 439855014677 Uncharacterized small protein [Function unknown]; Region: COG2879 439855014678 carbon starvation protein A; Provisional; Region: PRK15015 439855014679 Carbon starvation protein CstA; Region: CstA; pfam02554 439855014680 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 439855014681 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 439855014682 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 439855014683 dimer interface [polypeptide binding]; other site 439855014684 active site 439855014685 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 439855014686 substrate binding site [chemical binding]; other site 439855014687 catalytic residue [active] 439855014688 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 439855014689 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 439855014690 active site 439855014691 putative substrate binding pocket [chemical binding]; other site 439855014692 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 439855014693 homotrimer interaction site [polypeptide binding]; other site 439855014694 putative active site [active] 439855014695 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 439855014696 Na binding site [ion binding]; other site 439855014697 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 439855014698 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 439855014699 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 439855014700 putative active site [active] 439855014701 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 439855014702 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 439855014703 dimer interface [polypeptide binding]; other site 439855014704 ligand binding site [chemical binding]; other site 439855014705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855014706 dimerization interface [polypeptide binding]; other site 439855014707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 439855014708 dimer interface [polypeptide binding]; other site 439855014709 putative CheW interface [polypeptide binding]; other site 439855014710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 439855014711 D-galactonate transporter; Region: 2A0114; TIGR00893 439855014712 putative substrate translocation pore; other site 439855014713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 439855014714 DNA-binding site [nucleotide binding]; DNA binding site 439855014715 Transcriptional regulators [Transcription]; Region: GntR; COG1802 439855014716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 439855014717 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 439855014718 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 439855014719 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 439855014720 putative NAD(P) binding site [chemical binding]; other site 439855014721 catalytic Zn binding site [ion binding]; other site 439855014722 structural Zn binding site [ion binding]; other site 439855014723 phosphoglycerol transferase I; Provisional; Region: PRK03776 439855014724 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 439855014725 hypothetical protein; Provisional; Region: PRK11667 439855014726 DNA replication protein DnaC; Validated; Region: PRK07952 439855014727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 439855014728 Walker A motif; other site 439855014729 ATP binding site [chemical binding]; other site 439855014730 Walker B motif; other site 439855014731 primosomal protein DnaI; Provisional; Region: PRK02854 439855014732 hypothetical protein; Provisional; Region: PRK09917 439855014733 Uncharacterized conserved protein [Function unknown]; Region: COG2966 439855014734 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 439855014735 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 439855014736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855014737 DNA binding residues [nucleotide binding] 439855014738 dimerization interface [polypeptide binding]; other site 439855014739 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 439855014740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 439855014741 DNA binding residues [nucleotide binding] 439855014742 dimerization interface [polypeptide binding]; other site 439855014743 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 439855014744 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 439855014745 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 439855014746 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 439855014747 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 439855014748 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 439855014749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 439855014750 S-adenosylmethionine binding site [chemical binding]; other site 439855014751 DNA polymerase III subunit psi; Validated; Region: PRK06856 439855014752 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 439855014753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 439855014754 Coenzyme A binding pocket [chemical binding]; other site 439855014755 dUMP phosphatase; Provisional; Region: PRK09449 439855014756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855014757 motif II; other site 439855014758 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 439855014759 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 439855014760 G1 box; other site 439855014761 putative GEF interaction site [polypeptide binding]; other site 439855014762 GTP/Mg2+ binding site [chemical binding]; other site 439855014763 Switch I region; other site 439855014764 G2 box; other site 439855014765 G3 box; other site 439855014766 Switch II region; other site 439855014767 G4 box; other site 439855014768 G5 box; other site 439855014769 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 439855014770 periplasmic protein; Provisional; Region: PRK10568 439855014771 BON domain; Region: BON; pfam04972 439855014772 BON domain; Region: BON; pfam04972 439855014773 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 439855014774 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 439855014775 active site 439855014776 nucleophile elbow; other site 439855014777 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 439855014778 active site 439855014779 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 439855014780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 439855014781 FeS/SAM binding site; other site 439855014782 hypothetical protein; Provisional; Region: PRK10977 439855014783 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 439855014784 intersubunit interface [polypeptide binding]; other site 439855014785 active site 439855014786 catalytic residue [active] 439855014787 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 439855014788 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 439855014789 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 439855014790 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 439855014791 phosphopentomutase; Provisional; Region: PRK05362 439855014792 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 439855014793 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 439855014794 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 439855014795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855014796 non-specific DNA binding site [nucleotide binding]; other site 439855014797 salt bridge; other site 439855014798 sequence-specific DNA binding site [nucleotide binding]; other site 439855014799 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 439855014800 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 439855014801 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 439855014802 hypothetical protein; Provisional; Region: PRK11246 439855014803 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 439855014804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 439855014805 motif II; other site 439855014806 DNA repair protein RadA; Region: sms; TIGR00416 439855014807 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 439855014808 Walker A motif/ATP binding site; other site 439855014809 ATP binding site [chemical binding]; other site 439855014810 Walker B motif; other site 439855014811 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 439855014812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 439855014813 non-specific DNA binding site [nucleotide binding]; other site 439855014814 salt bridge; other site 439855014815 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 439855014816 sequence-specific DNA binding site [nucleotide binding]; other site 439855014817 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 439855014818 active site 439855014819 (T/H)XGH motif; other site 439855014820 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 439855014821 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 439855014822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 439855014823 Walker A/P-loop; other site 439855014824 ATP binding site [chemical binding]; other site 439855014825 Q-loop/lid; other site 439855014826 ABC transporter signature motif; other site 439855014827 Walker B; other site 439855014828 D-loop; other site 439855014829 H-loop/switch region; other site 439855014830 ABC transporter; Region: ABC_tran_2; pfam12848 439855014831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 439855014832 lytic murein transglycosylase; Provisional; Region: PRK11619 439855014833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 439855014834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 439855014835 catalytic residue [active] 439855014836 Trp operon repressor; Provisional; Region: PRK01381 439855014837 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 439855014838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 439855014839 catalytic core [active] 439855014840 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 439855014841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 439855014842 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 439855014843 hypothetical protein; Provisional; Region: PRK10756 439855014844 CreA protein; Region: CreA; pfam05981 439855014845 DNA-binding response regulator CreB; Provisional; Region: PRK11083 439855014846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855014847 active site 439855014848 phosphorylation site [posttranslational modification] 439855014849 intermolecular recognition site; other site 439855014850 dimerization interface [polypeptide binding]; other site 439855014851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855014852 DNA binding site [nucleotide binding] 439855014853 sensory histidine kinase CreC; Provisional; Region: PRK11100 439855014854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 439855014855 dimerization interface [polypeptide binding]; other site 439855014856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 439855014857 dimer interface [polypeptide binding]; other site 439855014858 phosphorylation site [posttranslational modification] 439855014859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 439855014860 ATP binding site [chemical binding]; other site 439855014861 Mg2+ binding site [ion binding]; other site 439855014862 G-X-G motif; other site 439855014863 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 439855014864 two-component response regulator; Provisional; Region: PRK11173 439855014865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 439855014866 active site 439855014867 phosphorylation site [posttranslational modification] 439855014868 intermolecular recognition site; other site 439855014869 dimerization interface [polypeptide binding]; other site 439855014870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 439855014871 DNA binding site [nucleotide binding] 439855014872 putative RNA methyltransferase; Provisional; Region: PRK10433 439855014873 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050