-- dump date 20140619_090915 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001739873.1 170650745 6106603 complement(257..496) 1 NC_010485.1 identified by Glimmer3; putative; hypothetical protein 496 6106603 EcSMS35_B0001 Escherichia coli SMS-3-5 hypothetical protein YP_001739873.1 257 R 439855 CDS YP_001739874.1 170650750 6106604 complement(661..2214) 1 NC_010485.1 identified by similarity to SP:P13658; match to protein family HMM PF03432; mobilization protein MbeA 2214 mbeA 6106604 mbeA Escherichia coli SMS-3-5 mobilization protein MbeA YP_001739874.1 661 R 439855 CDS YP_001739875.1 170650744 6106613 complement(2204..2551) 1 NC_010485.1 identified by similarity to SP:P13657; match to protein family HMM PF05713; mobilization protein MbeC 2551 mbeC 6106613 mbeC Escherichia coli SMS-3-5 mobilization protein MbeC YP_001739875.1 2204 R 439855 CDS YP_001739876.1 170650749 6106610 2558..2782 1 NC_010485.1 identified by similarity to SP:P03051; match to protein family HMM PF01815; regulatory protein Rop 2782 rop 6106610 rop Escherichia coli SMS-3-5 regulatory protein Rop YP_001739876.1 2558 D 439855 CDS YP_001739877.1 170650741 6106609 complement(2848..3096) 1 NC_010485.1 identified by Glimmer3; putative; hypothetical protein 3096 6106609 EcSMS35_B0005 Escherichia coli SMS-3-5 hypothetical protein YP_001739877.1 2848 R 439855 CDS YP_001739878.1 170650743 6106606 3153..3524 1 NC_010485.1 identified by similarity to GB:AAS58761.1; hypothetical protein 3524 6106606 EcSMS35_B0006 Escherichia coli SMS-3-5 hypothetical protein YP_001739878.1 3153 D 439855 CDS YP_001739879.1 170650742 6106612 3992..4333 1 NC_010485.1 identified by similarity to SP:P02985; match to protein family HMM PF03526; colicin-E1 immunity protein 4333 imm 6106612 imm Escherichia coli SMS-3-5 colicin-E1 immunity protein YP_001739879.1 3992 D 439855 CDS YP_001739880.1 170650746 6106605 complement(4330..5895) 1 NC_010485.1 identified by similarity to SP:P21178; match to protein family HMM PF01024; colicin-E1 protein 5895 cea 6106605 cea Escherichia coli SMS-3-5 colicin-E1 protein YP_001739880.1 4330 R 439855 CDS YP_001739881.1 170650747 6106607 6155..6592 1 NC_010485.1 identified by similarity to GB:AAB59142.1; hypothetical protein 6592 6106607 EcSMS35_B0009 Escherichia coli SMS-3-5 hypothetical protein YP_001739881.1 6155 D 439855 CDS YP_001739882.1 170650748 6106608 6676..7095 1 NC_010485.1 putative lipoprotein 7095 6106608 EcSMS35_B0010 Escherichia coli SMS-3-5 putative lipoprotein YP_001739882.1 6676 D 439855 CDS YP_001739883.1 170650755 6106614 165..866 1 NC_010486.1 identified by match to protein family HMM PF01051; initiator replication protein RepB 866 repB 6106614 repB Escherichia coli SMS-3-5 initiator replication protein RepB YP_001739883.1 165 D 439855 CDS YP_001739884.1 170650752 6106617 complement(1114..3273) 1 NC_010486.1 identified by match to protein family HMM PF03389; MobA/MobL family protein 3273 6106617 EcSMS35_C0002 Escherichia coli SMS-3-5 MobA/MobL family protein YP_001739884.1 1114 R 439855 CDS YP_001739885.1 170650753 6106616 3452..3706 1 NC_010486.1 identified by similarity to SP:P07114; putative mobilization protein C 3706 6106616 EcSMS35_C0004 Escherichia coli SMS-3-5 putative mobilization protein C YP_001739885.1 3452 D 439855 CDS YP_001739886.1 170650754 6106615 complement(3675..4040) 1 NC_010486.1 identified by Glimmer3; putative; hypothetical protein 4040 6106615 EcSMS35_C0003 Escherichia coli SMS-3-5 hypothetical protein YP_001739886.1 3675 R 439855 CDS YP_001739887.1 170650758 6106618 49..711 1 NC_010487.1 identified by Glimmer3; putative; hypothetical protein 711 6106618 EcSMS35_D0001 Escherichia coli SMS-3-5 hypothetical protein YP_001739887.1 49 D 439855 CDS YP_001739888.1 170650759 6106619 complement(1627..2223) 1 NC_010487.1 identified by Glimmer3; putative; hypothetical protein 2223 6106619 EcSMS35_D0003 Escherichia coli SMS-3-5 hypothetical protein YP_001739888.1 1627 R 439855 CDS YP_001739889.1 170650757 6106621 complement(2633..2842) 1 NC_010487.1 identified by Glimmer3; putative; hypothetical protein 2842 6106621 EcSMS35_D0004 Escherichia coli SMS-3-5 hypothetical protein YP_001739889.1 2633 R 439855 CDS YP_001739890.1 170650844 6106623 complement(154..540) 1 NC_010488.1 replication initiation protein repA4 540 6106623 EcSMS35_A0001 Escherichia coli SMS-3-5 replication initiation protein repA4 YP_001739890.1 154 R 439855 CDS YP_001739891.1 170650780 6106557 complement(904..1773) 1 NC_010488.1 RepA; replication protein 1773 repA1 6106557 repA1 Escherichia coli SMS-3-5 replication protein YP_001739891.1 904 R 439855 CDS YP_001739892.1 170650796 6106624 complement(2054..2314) 1 NC_010488.1 identified by similarity to SP:P62537; replication protein 2314 repA2 6106624 repA2 Escherichia coli SMS-3-5 replication protein YP_001739892.1 2054 R 439855 CDS YP_001739893.1 170650792 6106571 complement(3164..3373) 1 NC_010488.1 identified by similarity to SP:P0ACE3; match to protein family HMM PF05321; hypothetical protein 3373 6106571 EcSMS35_A0005 Escherichia coli SMS-3-5 hypothetical protein YP_001739893.1 3164 R 439855 CDS YP_001739894.1 170650855 6106576 complement(3419..3880) 1 NC_010488.1 identified by match to protein family HMM PF00565; nuclease homolog 3880 6106576 EcSMS35_A0006 Escherichia coli SMS-3-5 nuclease homolog YP_001739894.1 3419 R 439855 CDS YP_001739895.1 170650817 6106495 complement(4123..4335) 1 NC_010488.1 identified by similarity to RF:NP_958725.1; hypothetical protein 4335 6106495 EcSMS35_A0007 Escherichia coli SMS-3-5 hypothetical protein YP_001739895.1 4123 R 439855 CDS YP_001739896.1 170650904 6106539 complement(4473..5084) 1 NC_010488.1 identified by similarity to SP:P22707; match to protein family HMM PF05286; conjugal transfer fertility inhibition protein FinO 5084 finO 6106539 finO Escherichia coli SMS-3-5 conjugal transfer fertility inhibition protein FinO YP_001739896.1 4473 R 439855 CDS YP_001739897.1 170650820 6106490 complement(5088..5834) 1 NC_010488.1 identified by similarity to SP:P22709; match to protein family HMM PF05857; match to protein family HMM TIGR02755; conjugal transfer pilus acetylation protein TraX 5834 traX 6106490 traX Escherichia coli SMS-3-5 conjugal transfer pilus acetylation protein TraX YP_001739897.1 5088 R 439855 CDS YP_001739898.1 170650784 6106491 complement(5854..11124) 1 NC_010488.1 cleaves origin of transfer and unwinds; oriT relaxase; conjugal transfer nickase/helicase TraI 11124 traI 6106491 traI Escherichia coli SMS-3-5 conjugal transfer nickase/helicase TraI YP_001739898.1 5854 R 439855 CDS YP_001739899.1 170650889 6106602 complement(11124..13295) 1 NC_010488.1 type IV secretion system coupling protein; similar to F plasmid TraD; conjugal transfer protein TraD 13295 traD 6106602 traD Escherichia coli SMS-3-5 conjugal transfer protein TraD YP_001739899.1 11124 R 439855 CDS YP_001739900.1 170650825 6106527 complement(13548..14279) 1 NC_010488.1 identified by similarity to SP:P13979; match to protein family HMM PF05818; conjugal transfer surface exclusion protein TraT 14279 traT 6106527 traT Escherichia coli SMS-3-5 conjugal transfer surface exclusion protein TraT YP_001739900.1 13548 R 439855 CDS YP_001739901.1 170650886 6106516 complement(14311..14808) 1 NC_010488.1 identified by similarity to GB:ABC42218.1; putative type IV secretion-like conjugative transfer system protein TraS 14808 6106516 EcSMS35_A0013 Escherichia coli SMS-3-5 putative type IV secretion-like conjugative transfer system protein TraS YP_001739901.1 14311 R 439855 CDS YP_001739902.1 170650902 6106512 complement(14829..17651) 1 NC_010488.1 identified by similarity to SP:P33790; match to protein family HMM PF07916; conjugal transfer mating pair stabilization protein TraG 17651 traG 6106512 traG Escherichia coli SMS-3-5 conjugal transfer mating pair stabilization protein TraG YP_001739902.1 14829 R 439855 CDS YP_001739903.1 170650800 6106505 complement(17648..19024) 1 NC_010488.1 identified by similarity to SP:P15069; match to protein family HMM PF06122; conjugal transfer pilus assembly protein TraH 19024 traH 6106505 traH Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TraH YP_001739903.1 17648 R 439855 CDS YP_001739904.1 170650880 6106513 complement(19021..19383) 1 NC_010488.1 identified by similarity to SP:P18353; conjugal transfer protein TrbJ 19383 trbJ 6106513 trbJ Escherichia coli SMS-3-5 conjugal transfer protein TrbJ YP_001739904.1 19021 R 439855 CDS YP_001739905.1 170650781 6106508 complement(19313..19858) 1 NC_010488.1 identified by similarity to SP:P18035; match to protein family HMM TIGR02738; conjugal transfer protein TrbB 19858 trbB 6106508 trbB Escherichia coli SMS-3-5 conjugal transfer protein TrbB YP_001739905.1 19313 R 439855 CDS YP_001739906.1 170650897 6106589 complement(19845..20129) 1 NC_010488.1 identified by similarity to SP:P18033; match to protein family HMM TIGR02741; conjugal transfer pilin chaperone TraQ 20129 traQ 6106589 traQ Escherichia coli SMS-3-5 conjugal transfer pilin chaperone TraQ YP_001739906.1 19845 R 439855 CDS YP_001739907.1 170650822 6106577 complement(20248..20595) 1 NC_010488.1 identified by similarity to SP:P18034; conjugal transfer protein TrbA 20595 trbA 6106577 trbA Escherichia coli SMS-3-5 conjugal transfer protein TrbA YP_001739907.1 20248 R 439855 CDS YP_001739908.1 170650828 6106466 complement(20611..21354) 1 NC_010488.1 type IV secretion system pilus assembly protein; similar to F plasmid TraF; conjugal pilus assembly protein TraF 21354 traF 6106466 traF Escherichia coli SMS-3-5 conjugal pilus assembly protein TraF YP_001739908.1 20611 R 439855 CDS YP_001739909.1 170650840 6106528 complement(21347..21604) 1 NC_010488.1 identified by similarity to SP:Q05807; conjugal transfer protein TrbE 21604 trbE 6106528 trbE Escherichia coli SMS-3-5 conjugal transfer protein TrbE YP_001739909.1 21347 R 439855 CDS YP_001739910.1 170650771 6106499 complement(21631..23439) 1 NC_010488.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell; conjugal transfer mating pair stabilization protein TraN 23439 traN 6106499 traN Escherichia coli SMS-3-5 conjugal transfer mating pair stabilization protein TraN YP_001739910.1 21631 R 439855 CDS YP_001739911.1 170650809 6106494 complement(23436..24074) 1 NC_010488.1 identified by similarity to SP:P18473; match to protein family HMM TIGR02742; conjugal transfer pilus assembly protein TrbC 24074 trbC 6106494 trbC Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TrbC YP_001739911.1 23436 R 439855 CDS YP_001739912.1 170650862 6106579 complement(24102..24554) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 24554 6106579 EcSMS35_A0024 Escherichia coli SMS-3-5 hypothetical protein YP_001739912.1 24102 R 439855 CDS YP_001739913.1 170650772 6106551 complement(24584..25045) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 25045 6106551 EcSMS35_A0025 Escherichia coli SMS-3-5 hypothetical protein YP_001739913.1 24584 R 439855 CDS YP_001739914.1 170650911 6106486 complement(25071..26063) 1 NC_010488.1 identified by similarity to SP:P18471; match to protein family HMM PF06834; conjugal transfer pilus assembly protein TraU 26063 traU 6106486 traU Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TraU YP_001739914.1 25071 R 439855 CDS YP_001739915.1 170650832 6106485 complement(26060..26692) 1 NC_010488.1 identified by similarity to SP:P18472; match to protein family HMM TIGR02743; conjugal transfer pilus assembly protein TraW 26692 traW 6106485 traW Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TraW YP_001739915.1 26060 R 439855 CDS YP_001739916.1 170650810 6106479 complement(26689..27075) 1 NC_010488.1 identified by similarity to SP:P18006; match to protein family HMM TIGR02744; conjugal transfer protein TrbI 27075 trbI 6106479 trbI Escherichia coli SMS-3-5 conjugal transfer protein TrbI YP_001739916.1 26689 R 439855 CDS YP_001739917.1 170650779 6106572 complement(27072..29699) 1 NC_010488.1 similar to VirB4; conjugal transfer ATP-binding protein TraC 29699 traC 6106572 traC Escherichia coli SMS-3-5 conjugal transfer ATP-binding protein TraC YP_001739917.1 27072 R 439855 CDS YP_001739918.1 170650873 6106553 complement(29859..30080) 1 NC_010488.1 identified by similarity to SP:P41065; match to protein family HMM PF01258; match to protein family HMM TIGR02419; conjugal transfer protein TraR 30080 traR 6106553 traR Escherichia coli SMS-3-5 conjugal transfer protein TraR YP_001739918.1 29859 R 439855 CDS YP_001739919.1 170650794 6106549 complement(30215..30730) 1 NC_010488.1 identified by similarity to SP:P41069; match to protein family HMM TIGR02747; conjugal transfer protein TraV 30730 traV 6106549 traV Escherichia coli SMS-3-5 conjugal transfer protein TraV YP_001739919.1 30215 R 439855 CDS YP_001739920.1 170650806 6106563 complement(30727..30978) 1 NC_010488.1 identified by similarity to SP:P41072; conjugal transfer protein TrbG 30978 6106563 EcSMS35_A0032 Escherichia coli SMS-3-5 conjugal transfer protein TrbG YP_001739920.1 30727 R 439855 CDS YP_001739921.1 170650884 6106462 complement(30975..31292) 1 NC_010488.1 identified by similarity to SP:P41070; conjugal transfer protein TrbD 31292 6106462 EcSMS35_A0033 Escherichia coli SMS-3-5 conjugal transfer protein TrbD YP_001739921.1 30975 R 439855 CDS YP_001739922.1 170650891 6106538 complement(31289..31861) 1 NC_010488.1 identified by similarity to SP:P41068; match to protein family HMM PF07296; conjugal transfer protein TraP 31861 traP 6106538 traP Escherichia coli SMS-3-5 conjugal transfer protein TraP YP_001739922.1 31289 R 439855 CDS YP_001739923.1 170650812 6106630 complement(31851..33278) 1 NC_010488.1 identified by similarity to SP:P41067; match to protein family HMM PF06447; conjugal transfer pilus assembly protein TraB 33278 traB 6106630 traB Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TraB YP_001739923.1 31851 R 439855 CDS YP_001739924.1 170650906 6106500 complement(33278..34006) 1 NC_010488.1 identified by similarity to SP:P41066; match to protein family HMM PF06586; match to protein family HMM TIGR02756; conjugal transfer protein TraK 34006 traK 6106500 traK Escherichia coli SMS-3-5 conjugal transfer protein TraK YP_001739924.1 33278 R 439855 CDS YP_001739925.1 170650797 6106467 complement(33993..34559) 1 NC_010488.1 identified by similarity to SP:P08322; match to protein family HMM PF05309; match to protein family HMM TIGR02761; conjugal transfer pilus assembly protein TraE 34559 traE 6106467 traE Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TraE YP_001739925.1 33993 R 439855 CDS YP_001739926.1 170650856 6106631 complement(34581..34892) 1 NC_010488.1 identified by similarity to SP:P08321; match to protein family HMM PF07178; match to protein family HMM TIGR02762; conjugal transfer pilus assembly protein TraL 34892 traL 6106631 traL Escherichia coli SMS-3-5 conjugal transfer pilus assembly protein TraL YP_001739926.1 34581 R 439855 CDS YP_001739927.1 170650824 6106451 complement(34907..35266) 1 NC_010488.1 identified by similarity to SP:P04737; match to protein family HMM PF05513; match to protein family HMM TIGR02758; conjugal transfer pilin subunit TraA 35266 traA 6106451 traA Escherichia coli SMS-3-5 conjugal transfer pilin subunit TraA YP_001739927.1 34907 R 439855 CDS YP_001739928.1 170650869 6106595 complement(35300..35527) 1 NC_010488.1 identified by similarity to SP:P05836; conjugal transfer protein TraY 35527 traY 6106595 traY Escherichia coli SMS-3-5 conjugal transfer protein TraY YP_001739928.1 35300 R 439855 CDS YP_001739929.1 170650783 6106483 complement(35621..36307) 1 NC_010488.1 identified by similarity to SP:P05837; match to protein family HMM PF00989; type IV secretion-like conjugative transfer system regulator TraJ 36307 traJ 6106483 traJ Escherichia coli SMS-3-5 type IV secretion-like conjugative transfer system regulator TraJ YP_001739929.1 35621 R 439855 CDS YP_001739930.1 170650851 6106492 complement(36498..36881) 1 NC_010488.1 identified by similarity to SP:P10026; match to protein family HMM PF05261; conjugal transfer protein TraM 36881 traM 6106492 traM Escherichia coli SMS-3-5 conjugal transfer protein TraM YP_001739930.1 36498 R 439855 CDS YP_001739931.1 170650864 6106509 37158..37805 1 NC_010488.1 identified by match to protein family HMM PF01464; lytic transglycosylase 37805 6106509 EcSMS35_A0043 Escherichia coli SMS-3-5 lytic transglycosylase YP_001739931.1 37158 D 439855 CDS YP_001739932.1 170650793 6106511 complement(37831..37965) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 37965 6106511 EcSMS35_A0044 Escherichia coli SMS-3-5 hypothetical protein YP_001739932.1 37831 R 439855 CDS YP_001739933.1 170650799 6106480 complement(38102..38923) 1 NC_010488.1 identified by similarity to SP:P18005; match to protein family HMM PF06067; hypothetical protein 38923 6106480 EcSMS35_A0045 Escherichia coli SMS-3-5 hypothetical protein YP_001739933.1 38102 R 439855 CDS YP_001739934.1 170650769 6106590 complement(39046..39333) 1 NC_010488.1 identified by similarity to SP:Q02885; hypothetical protein 39333 6106590 EcSMS35_A0046 Escherichia coli SMS-3-5 hypothetical protein YP_001739934.1 39046 R 439855 CDS YP_001739935.1 170650803 6106622 complement(39358..39519) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 39519 6106622 EcSMS35_A0047 Escherichia coli SMS-3-5 hypothetical protein YP_001739935.1 39358 R 439855 CDS YP_001739936.1 170650770 6106520 complement(39600..39812) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 39812 6106520 EcSMS35_A0048 Escherichia coli SMS-3-5 hypothetical protein YP_001739936.1 39600 R 439855 CDS YP_001739937.1 170650839 6106473 complement(39805..39957) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 39957 6106473 EcSMS35_A0049 Escherichia coli SMS-3-5 hypothetical protein YP_001739937.1 39805 R 439855 CDS YP_001739938.1 170650845 6106478 complement(40255..40413) 1 NC_010488.1 identified by similarity to SP:P11895; match to protein family HMM PF01848; small toxic polypeptide 40413 hok 6106478 hok Escherichia coli SMS-3-5 small toxic polypeptide YP_001739938.1 40255 R 439855 CDS YP_001739939.1 170650801 6106450 complement(40556..40693) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 40693 6106450 EcSMS35_A0051 Escherichia coli SMS-3-5 hypothetical protein YP_001739939.1 40556 R 439855 CDS YP_001739940.1 170650870 6106522 complement(40693..41412) 1 NC_010488.1 PsiA; plasmid SOS inhibition protein A 41412 psiA 6106522 psiA Escherichia coli SMS-3-5 plasmid SOS inhibition protein A YP_001739940.1 40693 R 439855 CDS YP_001739941.1 170650814 6106599 complement(41409..41843) 1 NC_010488.1 identified by similarity to SP:P10032; match to protein family HMM PF06290; plasmid SOS inhibition protein B 41843 psiB 6106599 psiB Escherichia coli SMS-3-5 plasmid SOS inhibition protein B YP_001739941.1 41409 R 439855 CDS YP_001739942.1 170650892 6106574 complement(41898..43862) 1 NC_010488.1 identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; ParB-like partition protein 43862 6106574 EcSMS35_A0054 Escherichia coli SMS-3-5 ParB-like partition protein YP_001739942.1 41898 R 439855 CDS YP_001739943.1 170650898 6106518 complement(43915..44148) 1 NC_010488.1 identified by similarity to SP:Q5QJF4; match to protein family HMM PF06006; hypothetical protein 44148 6106518 EcSMS35_A0055 Escherichia coli SMS-3-5 hypothetical protein YP_001739943.1 43915 R 439855 CDS YP_001739944.1 170650901 6106536 complement(44204..44731) 1 NC_010488.1 identified by similarity to SP:P28044; match to protein family HMM PF00436; match to protein family HMM TIGR00621; single-stranded DNA-binding protein 44731 ssb1 6106536 ssb1 Escherichia coli SMS-3-5 single-stranded DNA-binding protein YP_001739944.1 44204 R 439855 CDS YP_001739945.1 170650786 6106496 complement(45374..45622) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 45622 6106496 EcSMS35_A0057 Escherichia coli SMS-3-5 hypothetical protein YP_001739945.1 45374 R 439855 CDS YP_001739946.1 170650791 6106578 complement(45622..46185) 1 NC_010488.1 identified by similarity to GB:AAR05681.1; hypothetical protein 46185 6106578 EcSMS35_A0058 Escherichia coli SMS-3-5 hypothetical protein YP_001739946.1 45622 R 439855 CDS YP_001739947.1 170650805 6106587 complement(46231..47592) 1 NC_010488.1 identified by similarity to GB:AAR05680.1; hypothetical protein 47592 6106587 EcSMS35_A0059 Escherichia coli SMS-3-5 hypothetical protein YP_001739947.1 46231 R 439855 CDS YP_001739948.1 170650777 6106596 complement(47644..47874) 1 NC_010488.1 identified by similarity to GB:AAR05679.1; hypothetical protein 47874 6106596 EcSMS35_A0060 Escherichia coli SMS-3-5 hypothetical protein YP_001739948.1 47644 R 439855 CDS YP_001739949.1 170650821 6106476 48137..48394 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 48394 6106476 EcSMS35_A0061 Escherichia coli SMS-3-5 hypothetical protein YP_001739949.1 48137 D 439855 CDS YP_001739950.1 170650850 6106540 complement(48448..48738) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 48738 6106540 EcSMS35_A0062 Escherichia coli SMS-3-5 hypothetical protein YP_001739950.1 48448 R 439855 CDS YP_001739951.1 170650877 6106477 complement(48868..49050) 1 NC_010488.1 identified by similarity to GB:AAS76404.1; hypothetical protein 49050 6106477 EcSMS35_A0063 Escherichia coli SMS-3-5 hypothetical protein YP_001739951.1 48868 R 439855 CDS YP_001739952.1 170650882 6106586 complement(49050..49421) 1 NC_010488.1 identified by similarity to GB:AAS76405.1; hypothetical protein 49421 6106586 EcSMS35_A0064 Escherichia coli SMS-3-5 hypothetical protein YP_001739952.1 49050 R 439855 CDS YP_001739953.1 170650827 6106489 complement(49511..49936) 1 NC_010488.1 identified by match to protein family HMM PF03230; putative antirestriction protein 49936 6106489 EcSMS35_A0065 Escherichia coli SMS-3-5 putative antirestriction protein YP_001739953.1 49511 R 439855 CDS YP_001739954.1 170650837 6106559 50016..50186 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 50186 6106559 EcSMS35_A0066 Escherichia coli SMS-3-5 hypothetical protein YP_001739954.1 50016 D 439855 CDS YP_001739955.1 170650843 6106569 50338..51309 1 NC_010488.1 identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS110 family transposase 51309 6106569 EcSMS35_A0067 Escherichia coli SMS-3-5 IS110 family transposase YP_001739955.1 50338 D 439855 CDS YP_001739956.1 170650785 6106546 complement(51362..51865) 1 NC_010488.1 identified by similarity to SP:P03830; match to protein family HMM PF03400; IS1 transposase orfB 51865 6106546 EcSMS35_A0068 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001739956.1 51362 R 439855 CDS YP_001739957.1 170650798 6106503 complement(51876..52088) 1 NC_010488.1 identified by similarity to GB:ABB64642.1; IS1 transposase orfA 52088 6106503 EcSMS35_A0069 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001739957.1 51876 R 439855 CDS YP_001739958.1 170650903 6106583 complement(52514..52657) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 52657 6106583 EcSMS35_A0070 Escherichia coli SMS-3-5 hypothetical protein YP_001739958.1 52514 R 439855 CDS YP_001739959.1 170650858 6106458 complement(52623..53036) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 53036 6106458 EcSMS35_A0071 Escherichia coli SMS-3-5 hypothetical protein YP_001739959.1 52623 R 439855 CDS YP_001739960.1 170650790 6106535 complement(53664..54635) 1 NC_010488.1 SopB; plasmid-partitioning protein 54635 sopB 6106535 sopB Escherichia coli SMS-3-5 plasmid-partitioning protein YP_001739960.1 53664 R 439855 CDS YP_001739961.1 170650895 6106519 complement(54635..55810) 1 NC_010488.1 identified by similarity to SP:P62556; match to protein family HMM PF00376; match to protein family HMM PF01656; plasmid-partitioning protein SopA 55810 sopA 6106519 sopA Escherichia coli SMS-3-5 plasmid-partitioning protein SopA YP_001739961.1 54635 R 439855 CDS YP_001739962.1 170650846 6106530 complement(56101..56604) 1 NC_010488.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 56604 6106530 EcSMS35_A0074 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001739962.1 56101 R 439855 CDS YP_001739963.1 170650774 6106633 complement(56615..56827) 1 NC_010488.1 identified by similarity to GB:ABB64642.1; IS1 transposase orfA 56827 6106633 EcSMS35_A0075 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001739963.1 56615 R 439855 CDS YP_001739964.1 170650830 6106573 complement(56954..58456) 1 NC_010488.1 identified by similarity to GB:CAL13433.1; hypothetical protein 58456 6106573 EcSMS35_A0076 Escherichia coli SMS-3-5 hypothetical protein YP_001739964.1 56954 R 439855 CDS YP_001739965.1 170650905 6106552 complement(59056..59481) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 59481 6106552 EcSMS35_A0077 Escherichia coli SMS-3-5 hypothetical protein YP_001739965.1 59056 R 439855 CDS YP_001739966.1 170650861 6106488 59638..60102 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 60102 6106488 EcSMS35_A0078 Escherichia coli SMS-3-5 hypothetical protein YP_001739966.1 59638 D 439855 CDS YP_001739967.1 170650883 6106484 complement(60178..60372) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 60372 6106484 EcSMS35_A0079 Escherichia coli SMS-3-5 hypothetical protein YP_001739967.1 60178 R 439855 CDS YP_001739968.1 170650834 6106632 60602..60793 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 60793 6106632 EcSMS35_A0080 Escherichia coli SMS-3-5 hypothetical protein YP_001739968.1 60602 D 439855 CDS YP_001739969.1 170650804 6106550 complement(61386..62243) 1 NC_010488.1 identified by similarity to GB:AAT11267.1; similarity to GB:ABA54734.1; match to protein family HMM PF00950; iron/manganese transport system membrane protein SitD 62243 sitD_1 6106550 sitD_1 Escherichia coli SMS-3-5 iron/manganese transport system membrane protein SitD YP_001739969.1 61386 R 439855 CDS YP_001739970.1 170650819 6106461 complement(62240..63097) 1 NC_010488.1 identified by similarity to GB:AAT11266.1; match to protein family HMM PF00950; match to protein family HMM PF01032; iron/manganese transport system membrane protein SitC 63097 sitC_1 6106461 sitC_1 Escherichia coli SMS-3-5 iron/manganese transport system membrane protein SitC YP_001739970.1 62240 R 439855 CDS YP_001739971.1 170650876 6106581 complement(63094..63921) 1 NC_010488.1 identified by similarity to GB:AAT11265.1; match to protein family HMM PF00005; iron/manganese transport system membrane protein SitB 63921 sitB_1 6106581 sitB_1 Escherichia coli SMS-3-5 iron/manganese transport system membrane protein SitB YP_001739971.1 63094 R 439855 CDS YP_001739972.1 170650778 6106487 complement(63921..64835) 1 NC_010488.1 identified by similarity to GB:AAT11264.1; match to protein family HMM PF01297; iron/manganese transport system periplasmic binding protein SitA 64835 sitA_1 6106487 sitA_1 Escherichia coli SMS-3-5 iron/manganese transport system periplasmic binding protein SitA YP_001739972.1 63921 R 439855 CDS YP_001739973.1 170650764 6106468 65162..65374 1 NC_010488.1 identified by similarity to GB:ABB64642.1; IS1 transposase orfA 65374 6106468 EcSMS35_A0085 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001739973.1 65162 D 439855 CDS YP_001739974.1 170650859 6106501 65385..65888 1 NC_010488.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 65888 6106501 EcSMS35_A0086 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001739974.1 65385 D 439855 CDS YP_001739975.1 170650841 6106544 67112..67288 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 67288 6106544 EcSMS35_A0089 Escherichia coli SMS-3-5 hypothetical protein YP_001739975.1 67112 D 439855 CDS YP_001739976.1 170650818 6106481 67356..67667 1 NC_010488.1 identified by similarity to GB:AAF94632.1; match to protein family HMM PF01527; hypothetical protein 67667 6106481 EcSMS35_A0090 Escherichia coli SMS-3-5 hypothetical protein YP_001739976.1 67356 D 439855 CDS YP_001739977.1 170650872 6106498 67680..67862 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 67862 6106498 EcSMS35_A0091 Escherichia coli SMS-3-5 hypothetical protein YP_001739977.1 67680 D 439855 CDS YP_001739978.1 170650815 6106554 67787..68533 1 NC_010488.1 identified by match to protein family HMM PF00665; integrase core subunit 68533 6106554 EcSMS35_A0092 Escherichia coli SMS-3-5 integrase core subunit YP_001739978.1 67787 D 439855 CDS YP_001739979.1 170650816 6106514 complement(68554..68778) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 68778 6106514 EcSMS35_A0093 Escherichia coli SMS-3-5 hypothetical protein YP_001739979.1 68554 R 439855 CDS YP_001739980.1 170650881 6106533 68915..69085 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 69085 6106533 EcSMS35_A0094 Escherichia coli SMS-3-5 hypothetical protein YP_001739980.1 68915 D 439855 CDS YP_001739981.1 170650788 6106469 69078..70055 1 NC_010488.1 identified by similarity to SP:Q57154; match to protein family HMM PF01051; repFIB replication protein A 70055 repA 6106469 repA Escherichia coli SMS-3-5 repFIB replication protein A YP_001739981.1 69078 D 439855 CDS YP_001739982.1 170650826 6106529 complement(70340..71080) 1 NC_010488.1 identified by match to protein family HMM PF00589; site-specific recombinase 71080 6106529 EcSMS35_A0096 Escherichia coli SMS-3-5 site-specific recombinase YP_001739982.1 70340 R 439855 CDS YP_001739983.1 170650860 6106565 complement(71763..72671) 1 NC_010488.1 identified by match to protein family HMM PF07395; Mig-14 family protein 72671 6106565 EcSMS35_A0097 Escherichia coli SMS-3-5 Mig-14 family protein YP_001739983.1 71763 R 439855 CDS YP_001739984.1 170650913 6106558 complement(72734..73843) 1 NC_010488.1 identified by similarity to GB:AAG43374.1; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; hemolysin F 73843 hlyF 6106558 hlyF Escherichia coli SMS-3-5 hemolysin F YP_001739984.1 72734 R 439855 CDS YP_001739985.1 170650768 6106504 complement(74276..75229) 1 NC_010488.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 75229 ompT 6106504 ompT Escherichia coli SMS-3-5 outer membrane protease YP_001739985.1 74276 R 439855 CDS YP_001739986.1 170650896 6106626 75333..75722 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 75722 6106626 EcSMS35_A0100 Escherichia coli SMS-3-5 hypothetical protein YP_001739986.1 75333 D 439855 CDS YP_001739987.1 170650823 6106515 76844..77170 1 NC_010488.1 identified by match to protein family HMM PF01527; IS629 transposase orfA 77170 6106515 EcSMS35_A0101 Escherichia coli SMS-3-5 IS629 transposase orfA YP_001739987.1 76844 D 439855 CDS YP_001739988.1 170650767 6106472 77170..78057 1 NC_010488.1 identified by match to protein family HMM PF00665; IS629 transposase orfB 78057 6106472 EcSMS35_A0102 Escherichia coli SMS-3-5 IS629 transposase orfB YP_001739988.1 77170 D 439855 CDS YP_001739989.1 170650776 6106463 78501..78713 1 NC_010488.1 identified by similarity to GB:ABB64642.1; IS1 transposase orfA 78713 6106463 EcSMS35_A0103 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001739989.1 78501 D 439855 CDS YP_001739990.1 170650848 6106464 78724..79227 1 NC_010488.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 79227 6106464 EcSMS35_A0104 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001739990.1 78724 D 439855 CDS YP_001739991.1 170650762 6106555 complement(80119..80400) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 80400 6106555 EcSMS35_A0105 Escherichia coli SMS-3-5 hypothetical protein YP_001739991.1 80119 R 439855 CDS YP_001739992.1 170650863 6106523 80919..81329 1 NC_010488.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 81329 6106523 EcSMS35_A0108 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001739992.1 80919 D 439855 CDS YP_001739993.1 170650857 6106475 81287..82192 1 NC_010488.1 identified by match to protein family HMM PF00665; IS2 transposase orfB 82192 6106475 EcSMS35_A0110 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001739993.1 81287 D 439855 CDS YP_001739994.1 170650908 6106457 82865..83680 1 NC_010488.1 identified by similarity to SP:P05820; colicin-M 83680 cma 6106457 cma Escherichia coli SMS-3-5 colicin-M YP_001739994.1 82865 D 439855 CDS YP_001739995.1 170650761 6106600 complement(83730..84155) 1 NC_010488.1 identified by similarity to SP:P18002; colicin-M immunity protein Cmi 84155 cmi 6106600 cmi Escherichia coli SMS-3-5 colicin-M immunity protein Cmi YP_001739995.1 83730 R 439855 CDS YP_001739996.1 170650847 6106534 complement(84261..85037) 1 NC_010488.1 identified by similarity to SP:P18021; match to protein family HMM PF00589; resolvase 85037 resD 6106534 resD Escherichia coli SMS-3-5 resolvase YP_001739996.1 84261 R 439855 CDS YP_001739997.1 170650849 6106531 complement(85049..85348) 1 NC_010488.1 identified by Glimmer3; putative; hypothetical protein 85348 6106531 EcSMS35_A0114 Escherichia coli SMS-3-5 hypothetical protein YP_001739997.1 85049 R 439855 CDS YP_001739998.1 170650765 6106628 85355..86077 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 86077 6106628 EcSMS35_A0115 Escherichia coli SMS-3-5 IS26 transposase YP_001739998.1 85355 D 439855 CDS YP_001739999.1 170650874 6106588 86840..87562 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 87562 6106588 EcSMS35_A0116 Escherichia coli SMS-3-5 IS26 transposase YP_001739999.1 86840 D 439855 CDS YP_001740000.1 170650787 6106497 complement(87706..88347) 1 NC_010488.1 identified by match to protein family HMM PF00302; chloramphenicol acetyltransferase 2 88347 cmlA 6106497 cmlA Escherichia coli SMS-3-5 chloramphenicol acetyltransferase 2 YP_001740000.1 87706 R 439855 CDS YP_001740001.1 170650789 6106525 complement(88497..88997) 1 NC_010488.1 identified by similarity to GB:ABG56838.1; hypothetical protein 88997 6106525 EcSMS35_A0118 Escherichia coli SMS-3-5 hypothetical protein YP_001740001.1 88497 R 439855 CDS YP_001740002.1 170650853 6106474 89059..89781 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 89781 6106474 EcSMS35_A0119 Escherichia coli SMS-3-5 IS26 transposase YP_001740002.1 89059 D 439855 CDS YP_001740003.1 170650836 6106580 complement(90229..91242) 1 NC_010488.1 identified by match to protein family HMM PF00589; match to protein family HMM PF02899; match to protein family HMM TIGR02249; integrase/recombinase 91242 6106580 EcSMS35_A0120 Escherichia coli SMS-3-5 integrase/recombinase YP_001740003.1 90229 R 439855 CDS YP_001740004.1 170650842 6106542 91389..91871 1 NC_010488.1 identified by similarity to SP:P11731; match to protein family HMM PF00186; dihydrofolate reductase type 5 91871 dhfrV 6106542 dhfrV Escherichia coli SMS-3-5 dihydrofolate reductase type 5 YP_001740004.1 91389 D 439855 CDS YP_001740005.1 170650833 6106561 91923..92645 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 92645 6106561 EcSMS35_A0122 Escherichia coli SMS-3-5 IS26 transposase YP_001740005.1 91923 D 439855 CDS YP_001740006.1 170650766 6106562 93016..95982 1 NC_010488.1 identified by match to protein family HMM PF01526; Tn3 family transposase 95982 6106562 EcSMS35_A0124 Escherichia coli SMS-3-5 Tn3 family transposase YP_001740006.1 93016 D 439855 CDS YP_001740007.1 170650868 6106566 96061..97065 1 NC_010488.1 identified by match to protein family HMM PF02371; IS5075 transposase 97065 6106566 EcSMS35_A0125 Escherichia coli SMS-3-5 IS5075 transposase YP_001740007.1 96061 D 439855 CDS YP_001740008.1 170650775 6106454 97562..97744 1 NC_010488.1 identified by similarity to GB:BAF38229.1; hypothetical protein 97744 6106454 EcSMS35_A0126 Escherichia coli SMS-3-5 hypothetical protein YP_001740008.1 97562 D 439855 CDS YP_001740009.1 170650912 6106465 97753..98568 1 NC_010488.1 identified by similarity to SP:P0AC11; match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase type-2 98568 sul2 6106465 sul2 Escherichia coli SMS-3-5 dihydropteroate synthase type-2 YP_001740009.1 97753 D 439855 CDS YP_001740010.1 170650773 6106570 98629..99432 1 NC_010488.1 identified by match to protein family HMM PF01636; aminoglycoside resistance protein A 99432 strA 6106570 strA Escherichia coli SMS-3-5 aminoglycoside resistance protein A YP_001740010.1 98629 D 439855 CDS YP_001740011.1 170650808 6106543 99438..100268 1 NC_010488.1 identified by match to protein family HMM PF04655; aminoglycoside resistance protein B 100268 strB 6106543 strB Escherichia coli SMS-3-5 aminoglycoside resistance protein B YP_001740011.1 99438 D 439855 CDS YP_001740012.1 170650838 6106593 complement(100499..101359) 1 NC_010488.1 identified by similarity to SP:P62593; match to protein family HMM PF00144; beta-lactamase TEM 101359 blaT 6106593 blaT Escherichia coli SMS-3-5 beta-lactamase TEM YP_001740012.1 100499 R 439855 CDS YP_001740013.1 170650795 6106507 101868..102590 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 102590 6106507 EcSMS35_A0132 Escherichia coli SMS-3-5 IS26 transposase YP_001740013.1 101868 D 439855 CDS YP_001740014.1 170650888 6106506 102959..104038 1 NC_010488.1 identified by match to protein family HMM PF00561; streptothricin acetyltransferase Sat-1 104038 sat 6106506 sat Escherichia coli SMS-3-5 streptothricin acetyltransferase Sat-1 YP_001740014.1 102959 D 439855 CDS YP_001740015.1 170650782 6106556 104134..104742 1 NC_010488.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490; HAD family hydrolase 104742 6106556 EcSMS35_A0134 Escherichia coli SMS-3-5 HAD family hydrolase YP_001740015.1 104134 D 439855 CDS YP_001740016.1 170650900 6106452 104788..105591 1 NC_010488.1 streptomycin 3'-adenyltransferase; aminoglycoside resistance protein 105591 aadA 6106452 aadA Escherichia coli SMS-3-5 aminoglycoside resistance protein YP_001740016.1 104788 D 439855 CDS YP_001740017.1 170650879 6106545 complement(105733..106455) 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 106455 6106545 EcSMS35_A0136 Escherichia coli SMS-3-5 IS26 transposase YP_001740017.1 105733 R 439855 CDS YP_001740018.1 170650835 6106568 complement(107266..108165) 1 NC_010488.1 identified by similarity to GB:AAR07693.1; hypothetical protein 108165 6106568 EcSMS35_A0138 Escherichia coli SMS-3-5 hypothetical protein YP_001740018.1 107266 R 439855 CDS YP_001740019.1 170650890 6106493 complement(108155..108445) 1 NC_010488.1 identified by similarity to GB:AAR07694.1; hypothetical protein 108445 6106493 EcSMS35_A0139 Escherichia coli SMS-3-5 hypothetical protein YP_001740019.1 108155 R 439855 CDS YP_001740020.1 170650885 6106521 108741..108971 1 NC_010488.1 identified by similarity to SP:Q05459; match to protein family HMM PF04014; plasmid maintenance protein VagC 108971 vagC 6106521 vagC Escherichia coli SMS-3-5 plasmid maintenance protein VagC YP_001740020.1 108741 D 439855 CDS YP_001740021.1 170650829 6106455 108968..109384 1 NC_010488.1 identified by match to protein family HMM PF01850; plasmid maintenance protein VagD 109384 vagD 6106455 vagD Escherichia coli SMS-3-5 plasmid maintenance protein VagD YP_001740021.1 108968 D 439855 CDS YP_001740022.1 170650811 6106471 complement(109546..111684) 1 NC_010488.1 identified by similarity to GB:BAB91601; hypothetical protein 111684 6106471 EcSMS35_A0142 Escherichia coli SMS-3-5 hypothetical protein YP_001740022.1 109546 R 439855 CDS YP_001740023.1 170650813 6106575 112038..112295 1 NC_010488.1 identified by similarity to GB:BAB91600; hypothetical protein 112295 6106575 EcSMS35_A0143 Escherichia coli SMS-3-5 hypothetical protein YP_001740023.1 112038 D 439855 CDS YP_001740024.1 170650866 6106510 112295..112885 1 NC_010488.1 identified by similarity to GB:BAB91599; hypothetical protein 112885 6106510 EcSMS35_A0144 Escherichia coli SMS-3-5 hypothetical protein YP_001740024.1 112295 D 439855 CDS YP_001740025.1 170650802 6106459 113148..114704 1 NC_010488.1 identified by similarity to GB:BAB91598; hypothetical protein 114704 6106459 EcSMS35_A0145 Escherichia coli SMS-3-5 hypothetical protein YP_001740025.1 113148 D 439855 CDS YP_001740026.1 170650894 6106585 114896..115513 1 NC_010488.1 identified by similarity to GB:BAB91597; hypothetical protein 115513 6106585 EcSMS35_A0146 Escherichia coli SMS-3-5 hypothetical protein YP_001740026.1 114896 D 439855 CDS YP_001740027.1 170650831 6106625 complement(115806..116885) 1 NC_010488.1 identified by match to protein family HMM PF03773; putative permease 116885 6106625 EcSMS35_A0147 Escherichia coli SMS-3-5 putative permease YP_001740027.1 115806 R 439855 CDS YP_001740028.1 170650909 6106449 116990..117313 1 NC_010488.1 identified by match to protein family HMM PF01022; ArsR family transcriptional regulator 117313 6106449 EcSMS35_A0148 Escherichia coli SMS-3-5 ArsR family transcriptional regulator YP_001740028.1 116990 D 439855 CDS YP_001740029.1 170650878 6106597 complement(117847..118569) 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 118569 6106597 EcSMS35_A0149 Escherichia coli SMS-3-5 IS26 transposase YP_001740029.1 117847 R 439855 CDS YP_001740030.1 170650893 6106524 118542..119474 1 NC_010488.1 identified by match to protein family HMM PF01526; Tn1721 transposase 119474 6106524 EcSMS35_A0150 Escherichia coli SMS-3-5 Tn1721 transposase YP_001740030.1 118542 D 439855 CDS YP_001740031.1 170650865 6106582 119532..119774 1 NC_010488.1 identified by similarity to GB:AAS76290; hypothetical protein 119774 6106582 EcSMS35_A0151 Escherichia coli SMS-3-5 hypothetical protein YP_001740031.1 119532 D 439855 CDS YP_001740032.1 170650887 6106470 complement(119806..120483) 1 NC_010488.1 identified by similarity to SP:P03038; match to protein family HMM PF00440; match to protein family HMM PF02909; tetracycline repressor protein, class A 120483 tetR 6106470 tetR Escherichia coli SMS-3-5 tetracycline repressor protein, class A YP_001740032.1 119806 R 439855 CDS YP_001740033.1 170650807 6106627 120487..121761 1 NC_010488.1 identified by similarity to SP:P02982; match to protein family HMM PF07690; match to protein family HMM TIGR00880; tetracycline resistance protein, class A 121761 tetA 6106627 tetA Escherichia coli SMS-3-5 tetracycline resistance protein, class A YP_001740033.1 120487 D 439855 CDS YP_001740034.1 170650899 6106532 complement(121793..122677) 1 NC_010488.1 identified by match to protein family HMM PF00892; drug/metabolite transporter 122677 6106532 EcSMS35_A0154 Escherichia coli SMS-3-5 drug/metabolite transporter YP_001740034.1 121793 R 439855 CDS YP_001740035.1 170650907 6106567 complement(122815..123222) 1 NC_010488.1 identified by similarity to GB:AAS76286.1; hypothetical protein 123222 6106567 EcSMS35_A0155 Escherichia coli SMS-3-5 hypothetical protein YP_001740035.1 122815 R 439855 CDS YP_001740036.1 170650852 6106601 complement(124842..125564) 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 125564 6106601 EcSMS35_A0156 Escherichia coli SMS-3-5 IS26 transposase YP_001740036.1 124842 R 439855 CDS YP_001740037.1 170650875 6106584 complement(126086..126901) 1 NC_010488.1 identified by similarity to SP:P00551; match to protein family HMM PF01636; aminoglycoside 3'-phosphotransferase 126901 6106584 EcSMS35_A0159 Escherichia coli SMS-3-5 aminoglycoside 3'-phosphotransferase YP_001740037.1 126086 R 439855 CDS YP_001740038.1 170650763 6106547 127034..127756 1 NC_010488.1 identified by match to protein family HMM PF00665; IS26 transposase 127756 6106547 EcSMS35_A0160 Escherichia coli SMS-3-5 IS26 transposase YP_001740038.1 127034 D 439855 CDS YP_001740039.1 170650871 6106460 complement(128635..128847) 1 NC_010488.1 identified by similarity to GB:ABB64642.1; IS1 transposase orfA 128847 6106460 EcSMS35_A0163 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001740039.1 128635 R 439855 CDS YP_001740040.1 170650854 6106502 complement(129067..129432) 1 NC_010488.1 identified by similarity to SP:P13976; match to protein family HMM PF02452; stable plasmid inheritance protein PemK 129432 pemK 6106502 pemK Escherichia coli SMS-3-5 stable plasmid inheritance protein PemK YP_001740040.1 129067 R 439855 CDS YP_001740041.1 170650910 6106517 complement(129401..129658) 1 NC_010488.1 identified by similarity to SP:P13975; match to protein family HMM PF04014; stable plasmid inheritance protein PemI 129658 pemI 6106517 pemI Escherichia coli SMS-3-5 stable plasmid inheritance protein PemI YP_001740041.1 129401 R 439855 CDS YP_001740042.1 170650867 6106537 complement(129751..130404) 1 NC_010488.1 identified by match to protein family HMM PF02517; CAAX amino protease 130404 6106537 EcSMS35_A0166 Escherichia coli SMS-3-5 CAAX amino protease YP_001740042.1 129751 R 439855 CDS YP_001742118.1 170684018 6142593 336..2798 1 NC_010498.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2798 thrA 6142593 thrA Escherichia coli SMS-3-5 bifunctional aspartokinase I/homoserine dehydrogenase I YP_001742118.1 336 D 439855 CDS YP_001742119.1 170681884 6143317 2800..3732 1 NC_010498.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 6143317 thrB Escherichia coli SMS-3-5 homoserine kinase YP_001742119.1 2800 D 439855 CDS YP_001742120.1 170682268 6146078 3733..5019 1 NC_010498.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 6146078 thrC Escherichia coli SMS-3-5 threonine synthase YP_001742120.1 3733 D 439855 CDS YP_001742121.1 170680562 6146467 complement(5309..5557) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 5557 6146467 EcSMS35_0004 Escherichia coli SMS-3-5 hypothetical protein YP_001742121.1 5309 R 439855 CDS YP_001742122.1 170682084 6144732 complement(5569..6345) 1 NC_010498.1 identified by match to protein family HMM PF03883; hypothetical protein 6345 6144732 EcSMS35_0005 Escherichia coli SMS-3-5 hypothetical protein YP_001742122.1 5569 R 439855 CDS YP_001742123.1 170680075 6146281 complement(6415..7845) 1 NC_010498.1 identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; amino acid carrier protein 7845 agcS 6146281 agcS Escherichia coli SMS-3-5 amino acid carrier protein YP_001742123.1 6415 R 439855 CDS YP_001742124.1 170681632 6144239 8061..9077 1 NC_010498.1 identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874; transaldolase B 9077 tal2 6144239 tal2 Escherichia coli SMS-3-5 transaldolase B YP_001742124.1 8061 D 439855 CDS YP_001742125.1 170683195 6145817 9192..9779 1 NC_010498.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9779 mogA 6145817 mogA Escherichia coli SMS-3-5 molybdenum cofactor biosynthesis protein MogA YP_001742125.1 9192 D 439855 CDS YP_001742126.1 170680604 6147415 complement(9814..10380) 1 NC_010498.1 identified by match to protein family HMM PF01184; hypothetical protein 10380 6147415 EcSMS35_0009 Escherichia coli SMS-3-5 hypothetical protein YP_001742126.1 9814 R 439855 CDS YP_001742127.1 170683397 6144778 complement(10529..11242) 1 NC_010498.1 identified by match to protein family HMM PF03667; hypothetical protein 11242 6144778 EcSMS35_0010 Escherichia coli SMS-3-5 hypothetical protein YP_001742127.1 10529 R 439855 CDS YP_001742128.1 170680475 6142683 complement(11267..11671) 1 NC_010498.1 hypothetical protein 11671 6142683 EcSMS35_0011 Escherichia coli SMS-3-5 hypothetical protein YP_001742128.1 11267 R 439855 CDS YP_001742129.1 170682035 6144644 12047..13963 1 NC_010498.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 13963 dnaK 6144644 dnaK Escherichia coli SMS-3-5 molecular chaperone DnaK YP_001742129.1 12047 D 439855 CDS YP_001742130.1 170683873 6146232 14052..15182 1 NC_010498.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 15182 dnaJ 6146232 dnaJ Escherichia coli SMS-3-5 chaperone protein DnaJ YP_001742130.1 14052 D 439855 CDS YP_001742131.1 170681886 6143168 16050..16811 1 NC_010498.1 identified by match to protein family HMM PF07135; hypothetical protein 16811 6143168 EcSMS35_0014 Escherichia coli SMS-3-5 hypothetical protein YP_001742131.1 16050 D 439855 CDS YP_001742132.1 170683329 6146080 16831..18324 1 NC_010498.1 identified by match to protein family HMM PF00884; sulfatase 18324 6146080 EcSMS35_0015 Escherichia coli SMS-3-5 sulfatase YP_001742132.1 16831 D 439855 CDS YP_001742133.1 170682715 6142614 18454..19698 1 NC_010498.1 identified by similarity to GB:AAX63939.1; hypothetical protein 19698 6142614 EcSMS35_0016 Escherichia coli SMS-3-5 hypothetical protein YP_001742133.1 18454 D 439855 CDS YP_001742134.1 170684120 6146923 19950..21116 1 NC_010498.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 21116 nhaA 6146923 nhaA Escherichia coli SMS-3-5 pH-dependent sodium/proton antiporter YP_001742134.1 19950 D 439855 CDS YP_001742135.1 170681624 6143420 21176..22081 1 NC_010498.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 22081 nhaR 6143420 nhaR Escherichia coli SMS-3-5 transcriptional activator NhaR YP_001742135.1 21176 D 439855 CDS YP_001742136.1 170681287 6145809 complement(22139..24178) 1 NC_010498.1 identified by match to protein family HMM PF01055; glycosyl hydrolase family protein 24178 6145809 EcSMS35_0019 Escherichia coli SMS-3-5 glycosyl hydrolase family protein YP_001742136.1 22139 R 439855 CDS YP_001742137.1 170680613 6145471 complement(24218..25591) 1 NC_010498.1 identified by similarity to SP:P96792; match to protein family HMM PF07690; match to protein family HMM TIGR00792; xylose-proton symporter 25591 xlyP 6145471 xlyP Escherichia coli SMS-3-5 xylose-proton symporter YP_001742137.1 24218 R 439855 CDS YP_001742138.1 170680097 6144787 25804..25926 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 25926 6144787 EcSMS35_0021 Escherichia coli SMS-3-5 hypothetical protein YP_001742138.1 25804 D 439855 CDS YP_001742139.1 170683345 6144261 complement(25999..26262) 1 NC_010498.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 26262 rpsT 6144261 rpsT Escherichia coli SMS-3-5 30S ribosomal protein S20 YP_001742139.1 25999 R 439855 CDS YP_001742140.1 170680169 6142631 26591..27532 1 NC_010498.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 27532 ribF 6142631 ribF Escherichia coli SMS-3-5 bifunctional riboflavin kinase/FMN adenylyltransferase YP_001742140.1 26591 D 439855 CDS YP_001742141.1 170684022 6144335 27575..30391 1 NC_010498.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 30391 ileS 6144335 ileS Escherichia coli SMS-3-5 isoleucyl-tRNA synthetase YP_001742141.1 27575 D 439855 CDS YP_001742142.1 170679728 6143321 30391..30885 1 NC_010498.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 30885 lspA 6143321 lspA Escherichia coli SMS-3-5 lipoprotein signal peptidase YP_001742142.1 30391 D 439855 CDS YP_001742143.1 170682408 6143886 30973..31422 1 NC_010498.1 identified by match to protein family HMM PF00254; FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase 31422 fkpB 6143886 fkpB Escherichia coli SMS-3-5 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase YP_001742143.1 30973 D 439855 CDS YP_001742144.1 170684275 6146607 31424..32374 1 NC_010498.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 32374 ispH 6146607 ispH Escherichia coli SMS-3-5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001742144.1 31424 D 439855 CDS YP_001742145.1 170680986 6143577 32440..33354 1 NC_010498.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 33354 rihC 6143577 rihC Escherichia coli SMS-3-5 ribonucleoside hydrolase RihC YP_001742145.1 32440 D 439855 CDS YP_001742146.1 170682871 6145167 33521..34342 1 NC_010498.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 34342 dapB 6145167 dapB Escherichia coli SMS-3-5 dihydrodipicolinate reductase YP_001742146.1 33521 D 439855 CDS YP_001742147.1 170679708 6147084 complement(34354..34536) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 34536 6147084 EcSMS35_0030 Escherichia coli SMS-3-5 hypothetical protein YP_001742147.1 34354 R 439855 CDS YP_001742148.1 170680139 6143866 34621..34758 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 34758 6143866 EcSMS35_0031 Escherichia coli SMS-3-5 hypothetical protein YP_001742148.1 34621 D 439855 CDS YP_001742149.1 170683312 6144305 34771..35946 1 NC_010498.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 35946 carA 6144305 carA Escherichia coli SMS-3-5 carbamoyl phosphate synthase small subunit YP_001742149.1 34771 D 439855 CDS YP_001742150.1 170680299 6142597 35964..39185 1 NC_010498.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 39185 carB 6142597 carB Escherichia coli SMS-3-5 carbamoyl phosphate synthase large subunit YP_001742150.1 35964 D 439855 CDS YP_001742151.1 170682795 6144467 complement(39193..39411) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 39411 6144467 EcSMS35_0034 Escherichia coli SMS-3-5 hypothetical protein YP_001742151.1 39193 R 439855 CDS YP_001742152.1 170680121 6147004 39446..39841 1 NC_010498.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 39841 caiF 6147004 caiF Escherichia coli SMS-3-5 DNA-binding transcriptional activator CaiF YP_001742152.1 39446 D 439855 CDS YP_001742153.1 170683173 6144286 complement(39960..40550) 1 NC_010498.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 40550 caiE 6144286 caiE Escherichia coli SMS-3-5 carnitine operon protein CaiE YP_001742153.1 39960 R 439855 CDS YP_001742154.1 170683826 6147393 complement(40556..41341) 1 NC_010498.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 41341 caiD 6147393 caiD Escherichia coli SMS-3-5 carnitinyl-CoA dehydratase YP_001742154.1 40556 R 439855 CDS YP_001742155.1 170681586 6143120 complement(41450..43003) 1 NC_010498.1 identified by match to protein family HMM PF00501; putative crotonobetaine/carnitine-CoA ligase 43003 caiC 6143120 caiC Escherichia coli SMS-3-5 putative crotonobetaine/carnitine-CoA ligase YP_001742155.1 41450 R 439855 CDS YP_001742156.1 170681966 6145771 complement(43077..44294) 1 NC_010498.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 44294 caiB 6145771 caiB Escherichia coli SMS-3-5 crotonobetainyl-CoA:carnitine CoA-transferase YP_001742156.1 43077 R 439855 CDS YP_001742157.1 170680462 6146162 complement(44423..45565) 1 NC_010498.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 45565 caiA 6146162 caiA Escherichia coli SMS-3-5 crotonobetainyl-CoA dehydrogenase YP_001742157.1 44423 R 439855 CDS YP_001742158.1 170680951 6144631 complement(45596..47110) 1 NC_010498.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 47110 caiT 6144631 caiT Escherichia coli SMS-3-5 L-carnitine/gamma-butyrobetaine antiporter YP_001742158.1 45596 R 439855 CDS YP_001742159.1 170683443 6145132 47226..47375 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 47375 6145132 EcSMS35_0042 Escherichia coli SMS-3-5 hypothetical protein YP_001742159.1 47226 D 439855 CDS YP_001742160.1 170684267 6142730 47583..48353 1 NC_010498.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 48353 fixA 6142730 fixA Escherichia coli SMS-3-5 putative electron transfer flavoprotein FixA YP_001742160.1 47583 D 439855 CDS YP_001742161.1 170682403 6143569 48368..49309 1 NC_010498.1 involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 49309 fixB 6143569 fixB Escherichia coli SMS-3-5 putative electron transfer flavoprotein FixB YP_001742161.1 48368 D 439855 CDS YP_001742162.1 170682933 6146602 49360..50646 1 NC_010498.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 50646 fixC 6146602 fixC Escherichia coli SMS-3-5 putative oxidoreductase FixC YP_001742162.1 49360 D 439855 CDS YP_001742163.1 170680948 6147147 50643..50930 1 NC_010498.1 ferredoxin FixX-like protein 50930 fixX 6147147 fixX Escherichia coli SMS-3-5 ferredoxin FixX-like protein YP_001742163.1 50643 D 439855 CDS YP_001742164.1 170681587 6145129 50989..52320 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 52320 6145129 EcSMS35_0047 Escherichia coli SMS-3-5 major facilitator family transporter YP_001742164.1 50989 D 439855 CDS YP_001742165.1 170679681 6145772 52428..52958 1 NC_010498.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 52958 kefF 6145772 kefF Escherichia coli SMS-3-5 glutathione-regulated potassium-efflux system ancillary protein KefF YP_001742165.1 52428 D 439855 CDS YP_001742166.1 170680033 6143839 52951..54813 1 NC_010498.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 54813 kefC 6143839 kefC Escherichia coli SMS-3-5 glutathione-regulated potassium-efflux system protein KefC YP_001742166.1 52951 D 439855 CDS YP_001742167.1 170680741 6144196 54894..55484 1 NC_010498.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 55484 folA 6144196 folA Escherichia coli SMS-3-5 dihydrofolate reductase YP_001742167.1 54894 D 439855 CDS YP_001742168.1 170683412 6144916 complement(55801..56250) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 56250 6144916 EcSMS35_0051 Escherichia coli SMS-3-5 hypothetical protein YP_001742168.1 55801 R 439855 CDS YP_001742169.1 170684105 6142698 complement(56286..56885) 1 NC_010498.1 hypothetical protein 56885 6142698 EcSMS35_0052 Escherichia coli SMS-3-5 hypothetical protein YP_001742169.1 56286 R 439855 CDS YP_001742170.1 170681134 6143405 complement(56910..57758) 1 NC_010498.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 57758 apaH 6143405 apaH Escherichia coli SMS-3-5 diadenosine tetraphosphatase YP_001742170.1 56910 R 439855 CDS YP_001742171.1 170681872 6145317 complement(57765..58142) 1 NC_010498.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 58142 apaG 6145317 apaG Escherichia coli SMS-3-5 ApaG protein YP_001742171.1 57765 R 439855 CDS YP_001742172.1 170683255 6146066 complement(58145..58966) 1 NC_010498.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 58966 ksgA 6146066 ksgA Escherichia coli SMS-3-5 dimethyladenosine transferase YP_001742172.1 58145 R 439855 CDS YP_001742173.1 170683725 6147478 complement(58963..59952) 1 NC_010498.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 59952 pdxA 6147478 pdxA Escherichia coli SMS-3-5 4-hydroxythreonine-4-phosphate dehydrogenase YP_001742173.1 58963 R 439855 CDS YP_001742174.1 170682162 6143017 complement(59952..61238) 1 NC_010498.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 61238 surA 6143017 surA Escherichia coli SMS-3-5 peptidyl-prolyl cis-trans isomerase SurA YP_001742174.1 59952 R 439855 CDS YP_001742175.1 170681284 6146361 complement(61291..63648) 1 NC_010498.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 63648 imp 6146361 imp Escherichia coli SMS-3-5 organic solvent tolerance protein YP_001742175.1 61291 R 439855 CDS YP_001742176.1 170681787 6145468 63903..64718 1 NC_010498.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 64718 djlA 6145468 djlA Escherichia coli SMS-3-5 Dna-J like membrane chaperone protein YP_001742176.1 63903 D 439855 CDS YP_001742177.1 170679993 6145979 complement(64836..65495) 1 NC_010498.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 65495 6145979 EcSMS35_0060 Escherichia coli SMS-3-5 23S rRNA/tRNA pseudouridine synthase A YP_001742177.1 64836 R 439855 CDS YP_001742178.1 170680507 6144155 complement(65507..68413) 1 NC_010498.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 68413 rapA 6144155 rapA Escherichia coli SMS-3-5 ATP-dependent helicase HepA YP_001742178.1 65507 R 439855 CDS YP_001742179.1 170683863 6144677 complement(68577..70928) 1 NC_010498.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 70928 polB 6144677 polB Escherichia coli SMS-3-5 DNA polymerase II YP_001742179.1 68577 R 439855 CDS YP_001742180.1 170683189 6143158 complement(71003..71698) 1 NC_010498.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 71698 araD 6143158 araD Escherichia coli SMS-3-5 L-ribulose-5-phosphate 4-epimerase YP_001742180.1 71003 R 439855 CDS YP_001742181.1 170682791 6147409 complement(71898..73400) 1 NC_010498.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 73400 araA 6147409 araA Escherichia coli SMS-3-5 L-arabinose isomerase YP_001742181.1 71898 R 439855 CDS YP_001742182.1 170683895 6147000 complement(73411..75111) 1 NC_010498.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 75111 araB 6147000 araB Escherichia coli SMS-3-5 ribulokinase YP_001742182.1 73411 R 439855 CDS YP_001742183.1 170683703 6143191 75450..76295 1 NC_010498.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 76295 araC 6143191 araC Escherichia coli SMS-3-5 DNA-binding transcriptional regulator AraC YP_001742183.1 75450 D 439855 CDS YP_001742184.1 170679653 6142995 76809..77657 1 NC_010498.1 identified by similarity to GB:CAG77221.1; hypothetical protein 77657 6142995 EcSMS35_0067 Escherichia coli SMS-3-5 hypothetical protein YP_001742184.1 76809 D 439855 CDS YP_001742185.1 170681643 6143810 77664..78086 1 NC_010498.1 identified by similarity to GB:AAG02753.1; hypothetical protein 78086 6143810 EcSMS35_0068 Escherichia coli SMS-3-5 hypothetical protein YP_001742185.1 77664 D 439855 CDS YP_001742186.1 170681148 6145829 78241..79005 1 NC_010498.1 identified by match to protein family HMM PF09335; hypothetical protein 79005 6145829 EcSMS35_0069 Escherichia coli SMS-3-5 hypothetical protein YP_001742186.1 78241 D 439855 CDS YP_001742187.1 170680825 6145331 complement(79075..79773) 1 NC_010498.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 79773 thiQ 6145331 thiQ Escherichia coli SMS-3-5 thiamine transporter ATP-binding subunit YP_001742187.1 79075 R 439855 CDS YP_001742188.1 170682672 6145002 complement(79757..81367) 1 NC_010498.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 81367 thiP 6145002 thiP Escherichia coli SMS-3-5 thiamine transporter membrane protein YP_001742188.1 79757 R 439855 CDS YP_001742189.1 170682457 6146880 complement(81343..82326) 1 NC_010498.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 82326 tbpA 6146880 tbpA Escherichia coli SMS-3-5 thiamine transporter substrate binding subunit YP_001742189.1 81343 R 439855 CDS YP_001742190.1 170681784 6146656 82784..83266 1 NC_010498.1 identified by similarity to GB:ABB60319.1; hypothetical protein 83266 6146656 EcSMS35_0073 Escherichia coli SMS-3-5 hypothetical protein YP_001742190.1 82784 D 439855 CDS YP_001742191.1 170681588 6145976 complement(83496..85154) 1 NC_010498.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 85154 sgrR 6145976 sgrR Escherichia coli SMS-3-5 transcriptional regulator SgrR YP_001742191.1 83496 R 439855 CDS YP_001742192.1 170680796 6145773 85243..85374 1 NC_010498.1 identified by similarity to GB:AAX64010.1; hypothetical protein 85374 6145773 EcSMS35_0075 Escherichia coli SMS-3-5 hypothetical protein YP_001742192.1 85243 D 439855 CDS YP_001742193.1 170682967 6144971 complement(85482..86087) 1 NC_010498.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 86087 leuD 6144971 leuD Escherichia coli SMS-3-5 isopropylmalate isomerase small subunit YP_001742193.1 85482 R 439855 CDS YP_001742194.1 170682290 6147182 complement(86098..87498) 1 NC_010498.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 87498 leuC 6147182 leuC Escherichia coli SMS-3-5 isopropylmalate isomerase large subunit YP_001742194.1 86098 R 439855 CDS YP_001742195.1 170684236 6146489 complement(87501..88592) 1 NC_010498.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 88592 leuB 6146489 leuB Escherichia coli SMS-3-5 3-isopropylmalate dehydrogenase YP_001742195.1 87501 R 439855 CDS YP_001742196.1 170683572 6143537 complement(88592..90163) 1 NC_010498.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 90163 leuA 6143537 leuA Escherichia coli SMS-3-5 2-isopropylmalate synthase YP_001742196.1 88592 R 439855 CDS YP_001742197.1 170680253 6142863 complement(90380..90511) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 90511 6142863 EcSMS35_0080 Escherichia coli SMS-3-5 hypothetical protein YP_001742197.1 90380 R 439855 CDS YP_001742198.1 170679841 6144420 91001..91945 1 NC_010498.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 91945 leuO 6144420 leuO Escherichia coli SMS-3-5 leucine transcriptional activator YP_001742198.1 91001 D 439855 CDS YP_001742199.1 170681517 6144003 complement(91981..92103) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 92103 6144003 EcSMS35_0082 Escherichia coli SMS-3-5 hypothetical protein YP_001742199.1 91981 R 439855 CDS YP_001742200.1 170683042 6145702 92173..93987 1 NC_010498.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 93987 ilvI 6145702 ilvI Escherichia coli SMS-3-5 acetolactate synthase 3 catalytic subunit YP_001742200.1 92173 D 439855 CDS YP_001742201.1 170682993 6147258 93960..94481 1 NC_010498.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 94481 ilvH 6147258 ilvH Escherichia coli SMS-3-5 acetolactate synthase 3 regulatory subunit YP_001742201.1 93960 D 439855 CDS YP_001742202.1 170683499 6147209 94661..95665 1 NC_010498.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 95665 fruR 6147209 fruR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator FruR YP_001742202.1 94661 D 439855 CDS YP_001742203.1 170684017 6142788 96267..96725 1 NC_010498.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 96725 mraZ 6142788 mraZ Escherichia coli SMS-3-5 cell division protein MraZ YP_001742203.1 96267 D 439855 CDS YP_001742204.1 170679711 6143316 96727..97668 1 NC_010498.1 identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 97668 mraW 6143316 mraW Escherichia coli SMS-3-5 S-adenosyl-methyltransferase MraW YP_001742204.1 96727 D 439855 CDS YP_001742205.1 170680807 6143869 97665..98030 1 NC_010498.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 98030 ftsL 6143869 ftsL Escherichia coli SMS-3-5 cell division protein FtsL YP_001742205.1 97665 D 439855 CDS YP_001742206.1 170681597 6144983 98046..99812 1 NC_010498.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; peptidoglycan synthetase FtsI 99812 ftsI 6144983 ftsI Escherichia coli SMS-3-5 peptidoglycan synthetase FtsI YP_001742206.1 98046 D 439855 CDS YP_001742207.1 170682313 6145782 99799..101286 1 NC_010498.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 101286 murE 6145782 murE Escherichia coli SMS-3-5 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001742207.1 99799 D 439855 CDS YP_001742208.1 170682834 6146512 101283..102641 1 NC_010498.1 identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 102641 murF 6146512 murF Escherichia coli SMS-3-5 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_001742208.1 101283 D 439855 CDS YP_001742209.1 170684044 6147045 102635..103717 1 NC_010498.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 103717 mraY 6147045 mraY Escherichia coli SMS-3-5 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001742209.1 102635 D 439855 CDS YP_001742210.1 170681706 6143343 103720..105036 1 NC_010498.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 105036 murD 6143343 murD Escherichia coli SMS-3-5 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001742210.1 103720 D 439855 CDS YP_001742211.1 170682663 6145892 105036..106280 1 NC_010498.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 106280 ftsW 6145892 ftsW Escherichia coli SMS-3-5 cell division protein FtsW YP_001742211.1 105036 D 439855 CDS YP_001742212.1 170683320 6146870 106277..107344 1 NC_010498.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 107344 murG 6146870 murG Escherichia coli SMS-3-5 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001742212.1 106277 D 439855 CDS YP_001742213.1 170683694 6142605 107398..108873 1 NC_010498.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 108873 murC 6142605 murC Escherichia coli SMS-3-5 UDP-N-acetylmuramate--L-alanine ligase YP_001742213.1 107398 D 439855 CDS YP_001742214.1 170683837 6142986 108866..109786 1 NC_010498.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 109786 ddl 6142986 ddl Escherichia coli SMS-3-5 D-alanine--D-alanine ligase YP_001742214.1 108866 D 439855 CDS YP_001742215.1 170680072 6143131 109788..110618 1 NC_010498.1 involved in septum formation; cell division protein FtsQ 110618 ftsQ 6143131 ftsQ Escherichia coli SMS-3-5 cell division protein FtsQ YP_001742215.1 109788 D 439855 CDS YP_001742216.1 170680487 6144236 110615..111877 1 NC_010498.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 111877 ftsA 6144236 ftsA Escherichia coli SMS-3-5 cell division protein FtsA YP_001742216.1 110615 D 439855 CDS YP_001742217.1 170681165 6144656 111939..113090 1 NC_010498.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 113090 ftsZ 6144656 ftsZ Escherichia coli SMS-3-5 cell division protein FtsZ YP_001742217.1 111939 D 439855 CDS YP_001742218.1 170681175 6145349 113191..114108 1 NC_010498.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 114108 lpxC 6145349 lpxC Escherichia coli SMS-3-5 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001742218.1 113191 D 439855 CDS YP_001742219.1 170682119 6145359 114264..114851 1 NC_010498.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 114851 secM 6145359 secM Escherichia coli SMS-3-5 SecA regulator SecM YP_001742219.1 114264 D 439855 CDS YP_001742220.1 170680792 6146317 114913..117618 1 NC_010498.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 117618 secA 6146317 secA Escherichia coli SMS-3-5 preprotein translocase subunit SecA YP_001742220.1 114913 D 439855 CDS YP_001742221.1 170682809 6144967 117678..118076 1 NC_010498.1 identified by match to protein family HMM PF00293; match to protein family HMM TIGR00586; nucleoside triphosphate pyrophosphohydrolase 118076 mutT 6144967 mutT Escherichia coli SMS-3-5 nucleoside triphosphate pyrophosphohydrolase YP_001742221.1 117678 D 439855 CDS YP_001742222.1 170683016 6147020 complement(118165..118362) 1 NC_010498.1 identified by match to protein family HMM PF03884; zinc-binding protein 118362 6147020 EcSMS35_0105 Escherichia coli SMS-3-5 zinc-binding protein YP_001742222.1 118165 R 439855 CDS YP_001742223.1 170683836 6147232 complement(118372..119115) 1 NC_010498.1 identified by match to protein family HMM PF07072; hypothetical protein 119115 6147232 EcSMS35_0106 Escherichia coli SMS-3-5 hypothetical protein YP_001742223.1 118372 R 439855 CDS YP_001742224.1 170684117 6143130 complement(119115..119735) 1 NC_010498.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 119735 coaE 6143130 coaE Escherichia coli SMS-3-5 dephospho-CoA kinase YP_001742224.1 119115 R 439855 CDS YP_001742225.1 170683674 6143417 119960..121003 1 NC_010498.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 121003 guaC 6143417 guaC Escherichia coli SMS-3-5 guanosine 5'-monophosphate oxidoreductase YP_001742225.1 119960 D 439855 CDS YP_001742226.1 170681709 6142966 complement(121038..122240) 1 NC_010498.1 identified by match to protein family HMM PF00482; type IV pilin biogenesis protein 122240 pilC 6142966 pilC Escherichia coli SMS-3-5 type IV pilin biogenesis protein YP_001742226.1 121038 R 439855 CDS YP_001742227.1 170681105 6145896 complement(122230..123615) 1 NC_010498.1 identified by match to protein family HMM PF00437; hypothetical protein 123615 hofB 6145896 hofB Escherichia coli SMS-3-5 hypothetical protein YP_001742227.1 122230 R 439855 CDS YP_001742228.1 170682801 6145287 complement(123625..124065) 1 NC_010498.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; putative major pilin subunit 124065 pilA 6145287 pilA Escherichia coli SMS-3-5 putative major pilin subunit YP_001742228.1 123625 R 439855 CDS YP_001742229.1 170681997 6147011 complement(124268..125161) 1 NC_010498.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 125161 nadC 6147011 nadC Escherichia coli SMS-3-5 quinolinate phosphoribosyltransferase YP_001742229.1 124268 R 439855 CDS YP_001742230.1 170683851 6146193 125249..125800 1 NC_010498.1 identified by match to protein family HMM PF01510; N-acetyl-anhydromuranmyl-L-alanine amidase 125800 ampD 6146193 ampD Escherichia coli SMS-3-5 N-acetyl-anhydromuranmyl-L-alanine amidase YP_001742230.1 125249 D 439855 CDS YP_001742231.1 170680046 6143145 125797..126651 1 NC_010498.1 involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 126651 ampE 6143145 ampE Escherichia coli SMS-3-5 regulatory protein AmpE YP_001742231.1 125797 D 439855 CDS YP_001742232.1 170680377 6144209 complement(126694..128064) 1 NC_010498.1 identified by similarity to SP:P15993; match to protein family HMM PF00324; aromatic amino acid transporter 128064 aroP 6144209 aroP Escherichia coli SMS-3-5 aromatic amino acid transporter YP_001742232.1 126694 R 439855 CDS YP_001742233.1 170680765 6144545 128593..130374 1 NC_010498.1 identified by match to protein family HMM PF01844; match to protein family HMM PF05638; match to protein family HMM PF06958; match to protein family HMM TIGR03344; putative S-type colicin 130374 6144545 EcSMS35_0116 Escherichia coli SMS-3-5 putative S-type colicin YP_001742233.1 128593 D 439855 CDS YP_001742234.1 170681742 6144940 130377..130661 1 NC_010498.1 putative colicin immunity protein 130661 6144940 EcSMS35_0117 Escherichia coli SMS-3-5 putative colicin immunity protein YP_001742234.1 130377 D 439855 CDS YP_001742235.1 170682972 6145931 130829..131068 1 NC_010498.1 putative colicin 131068 6145931 EcSMS35_0118 Escherichia coli SMS-3-5 putative colicin YP_001742235.1 130829 D 439855 CDS YP_001742236.1 170681564 6147187 131069..131359 1 NC_010498.1 identified by match to protein family HMM PF01320; putative colicin immunity protein 131359 6147187 EcSMS35_0119 Escherichia coli SMS-3-5 putative colicin immunity protein YP_001742236.1 131069 D 439855 CDS YP_001742237.1 170682281 6145749 131526..131714 1 NC_010498.1 putative colicin 131714 6145749 EcSMS35_0120 Escherichia coli SMS-3-5 putative colicin YP_001742237.1 131526 D 439855 CDS YP_001742238.1 170683102 6146480 131762..132058 1 NC_010498.1 identified by match to protein family HMM PF01320; putative colicin immunity protein 132058 6146480 EcSMS35_0121 Escherichia coli SMS-3-5 putative colicin immunity protein YP_001742238.1 131762 D 439855 CDS YP_001742239.1 170679674 6147321 132514..133278 1 NC_010498.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 133278 pdhR 6147321 pdhR Escherichia coli SMS-3-5 transcriptional regulator PdhR YP_001742239.1 132514 D 439855 CDS YP_001742240.1 170683479 6143832 complement(133275..133457) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 133457 6143832 EcSMS35_0122 Escherichia coli SMS-3-5 hypothetical protein YP_001742240.1 133275 R 439855 CDS YP_001742241.1 170680617 6142768 133439..136102 1 NC_010498.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 136102 aceE 6142768 aceE Escherichia coli SMS-3-5 pyruvate dehydrogenase subunit E1 YP_001742241.1 133439 D 439855 CDS YP_001742242.1 170680247 6144791 136117..138009 1 NC_010498.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 138009 aceF 6144791 aceF Escherichia coli SMS-3-5 dihydrolipoamide acetyltransferase YP_001742242.1 136117 D 439855 CDS YP_001742243.1 170679767 6144414 138154..139641 1 NC_010498.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 139641 lpdA 6144414 lpdA Escherichia coli SMS-3-5 dihydrolipoamide dehydrogenase YP_001742243.1 138154 D 439855 CDS YP_001742244.1 170684092 6143926 complement(139712..141469) 1 NC_010498.1 identified by similarity to GB:AAZ86919.1; hypothetical protein 141469 6143926 EcSMS35_0127 Escherichia coli SMS-3-5 hypothetical protein YP_001742244.1 139712 R 439855 CDS YP_001742245.1 170683451 6143392 141902..144421 1 NC_010498.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 144421 acnB 6143392 acnB Escherichia coli SMS-3-5 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_001742245.1 141902 D 439855 CDS YP_001742246.1 170683045 6142738 144596..144958 1 NC_010498.1 identified by match to protein family HMM PF06062; hypothetical protein 144958 6142738 EcSMS35_0129 Escherichia coli SMS-3-5 hypothetical protein YP_001742246.1 144596 D 439855 CDS YP_001742247.1 170682621 6147261 complement(144996..145790) 1 NC_010498.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 145790 speD 6147261 speD Escherichia coli SMS-3-5 S-adenosylmethionine decarboxylase YP_001742247.1 144996 R 439855 CDS YP_001742248.1 170683238 6146827 complement(145806..146672) 1 NC_010498.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 146672 speE 6146827 speE Escherichia coli SMS-3-5 spermidine synthase YP_001742248.1 145806 R 439855 CDS YP_001742249.1 170680607 6147459 complement(146778..147125) 1 NC_010498.1 hypothetical protein 147125 6147459 EcSMS35_0132 Escherichia coli SMS-3-5 hypothetical protein YP_001742249.1 146778 R 439855 CDS YP_001742250.1 170682517 6144781 147291..148841 1 NC_010498.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 148841 cueO 6144781 cueO Escherichia coli SMS-3-5 multicopper oxidase YP_001742250.1 147291 D 439855 CDS YP_001742251.1 170683523 6146718 complement(148888..151278) 1 NC_010498.1 identified by match to protein family HMM PF01011; match to protein family HMM TIGR03074; quinoprotein glucose dehydrogenase 151278 gcd 6146718 gcd Escherichia coli SMS-3-5 quinoprotein glucose dehydrogenase YP_001742251.1 148888 R 439855 CDS YP_001742252.1 170680010 6142813 151484..152020 1 NC_010498.1 identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 152020 hpt 6142813 hpt Escherichia coli SMS-3-5 hypoxanthine phosphoribosyltransferase YP_001742252.1 151484 D 439855 CDS YP_001742253.1 170680677 6144173 complement(152061..152723) 1 NC_010498.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 152723 can 6144173 can Escherichia coli SMS-3-5 carbonic anhydrase YP_001742253.1 152061 R 439855 CDS YP_001742254.1 170681249 6144852 152832..153758 1 NC_010498.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 153758 6144852 EcSMS35_0137 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001742254.1 152832 D 439855 CDS YP_001742255.1 170679696 6145433 153755..154525 1 NC_010498.1 identified by match to protein family HMM PF01061; ABC transporter permease 154525 6145433 EcSMS35_0138 Escherichia coli SMS-3-5 ABC transporter permease YP_001742255.1 153755 D 439855 CDS YP_001742256.1 170682787 6143854 154630..155070 1 NC_010498.1 identified by match to protein family HMM PF03610; PTS system IIA component domain-containing protein 155070 6143854 EcSMS35_0139 Escherichia coli SMS-3-5 PTS system IIA component domain-containing protein YP_001742256.1 154630 D 439855 CDS YP_001742257.1 170680801 6146996 155134..156363 1 NC_010498.1 identified by match to protein family HMM PF01522; polysaccharide deacetylase domain-containing protein 156363 6146996 EcSMS35_0140 Escherichia coli SMS-3-5 polysaccharide deacetylase domain-containing protein YP_001742257.1 155134 D 439855 CDS YP_001742258.1 170683804 6144977 complement(156367..156747) 1 NC_010498.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 156747 panD 6144977 panD Escherichia coli SMS-3-5 aspartate alpha-decarboxylase YP_001742258.1 156367 R 439855 CDS YP_001742259.1 170682409 6143098 157021..157941 1 NC_010498.1 yadD; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; ISNCY family transposase 157941 6143098 EcSMS35_0142 Escherichia coli SMS-3-5 ISNCY family transposase YP_001742259.1 157021 D 439855 CDS YP_001742260.1 170681773 6146608 158010..158225 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 158225 6146608 EcSMS35_0143 Escherichia coli SMS-3-5 hypothetical protein YP_001742260.1 158010 D 439855 CDS YP_001742261.1 170679778 6145965 complement(158307..159158) 1 NC_010498.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 159158 panC 6145965 panC Escherichia coli SMS-3-5 pantoate--beta-alanine ligase YP_001742261.1 158307 R 439855 CDS YP_001742262.1 170682456 6143937 complement(159170..159964) 1 NC_010498.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 159964 panB 6143937 panB Escherichia coli SMS-3-5 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_001742262.1 159170 R 439855 CDS YP_001742263.1 170682836 6146655 complement(160076..161347) 1 NC_010498.1 identified by match to protein family HMM PF00419; putative fimbrial-like adhesin protein 161347 6146655 EcSMS35_0146 Escherichia coli SMS-3-5 putative fimbrial-like adhesin protein YP_001742263.1 160076 R 439855 CDS YP_001742264.1 170680339 6147047 complement(161401..161997) 1 NC_010498.1 identified by similarity to SP:P12267; putative fimbrial protein 161997 6147047 EcSMS35_0147 Escherichia coli SMS-3-5 putative fimbrial protein YP_001742264.1 161401 R 439855 CDS YP_001742265.1 170681181 6144507 complement(162024..162629) 1 NC_010498.1 identified by similarity to GB:AAZ86940.1; hypothetical protein 162629 6144507 EcSMS35_0148 Escherichia coli SMS-3-5 hypothetical protein YP_001742265.1 162024 R 439855 CDS YP_001742266.1 170683790 6145365 complement(162644..163210) 1 NC_010498.1 yadM; identified by match to protein family HMM PF00419; fimbrial protein 163210 6145365 EcSMS35_0149 Escherichia coli SMS-3-5 fimbrial protein YP_001742266.1 162644 R 439855 CDS YP_001742267.1 170679612 6143082 complement(163230..165830) 1 NC_010498.1 similar to the fimbrial usher protein PapC; putative outer membrane usher protein 165830 htrE 6143082 htrE Escherichia coli SMS-3-5 putative outer membrane usher protein YP_001742267.1 163230 R 439855 CDS YP_001742268.1 170680970 6143769 complement(165865..166605) 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putative chaperone protein EcpD 166605 6143769 EcSMS35_0151 Escherichia coli SMS-3-5 putative chaperone protein EcpD YP_001742268.1 165865 R 439855 CDS YP_001742269.1 170681382 6145151 complement(166703..167287) 1 NC_010498.1 identified by match to protein family HMM PF00419; fimbrial protein 167287 6145151 EcSMS35_0152 Escherichia coli SMS-3-5 fimbrial protein YP_001742269.1 166703 R 439855 CDS YP_001742270.1 170680561 6145566 complement(167658..168137) 1 NC_010498.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase 168137 folK 6145566 folK Escherichia coli SMS-3-5 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase YP_001742270.1 167658 R 439855 CDS YP_001742271.1 170680324 6144731 complement(168134..169498) 1 NC_010498.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I 169498 pcnB 6144731 pcnB Escherichia coli SMS-3-5 poly(A) polymerase I YP_001742271.1 168134 R 439855 CDS YP_001742272.1 170683546 6144492 complement(169591..170517) 1 NC_010498.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 170517 gluQ 6144492 gluQ Escherichia coli SMS-3-5 glutamyl-Q tRNA(Asp) synthetase YP_001742272.1 169591 R 439855 CDS YP_001742273.1 170679800 6142836 complement(170554..171009) 1 NC_010498.1 identified by match to protein family HMM PF01258; match to protein family HMM TIGR02420; RNA polymerase-binding transcription factor 171009 dksA 6142836 dksA Escherichia coli SMS-3-5 RNA polymerase-binding transcription factor YP_001742273.1 170554 R 439855 CDS YP_001742274.1 170682246 6143960 complement(171187..171891) 1 NC_010498.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 171891 sfsA 6143960 sfsA Escherichia coli SMS-3-5 sugar fermentation stimulation protein A YP_001742274.1 171187 R 439855 CDS YP_001742275.1 170684250 6146445 complement(171906..172436) 1 NC_010498.1 identified by match to protein family HMM PF02834; match to protein family HMM TIGR02258; 2'-5' RNA ligase 172436 ligT 6146445 ligT Escherichia coli SMS-3-5 2'-5' RNA ligase YP_001742275.1 171906 R 439855 CDS YP_001742276.1 170681199 6143552 172465..174939 1 NC_010498.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 174939 hrpB 6143552 hrpB Escherichia coli SMS-3-5 ATP-dependent RNA helicase HrpB YP_001742276.1 172465 D 439855 CDS YP_001742277.1 170683049 6145383 175033..177567 1 NC_010498.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 177567 mrcB 6145383 mrcB Escherichia coli SMS-3-5 penicillin-binding protein 1b YP_001742277.1 175033 D 439855 CDS YP_001742278.1 170679586 6147265 complement(177632..177766) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 177766 6147265 EcSMS35_0161 Escherichia coli SMS-3-5 hypothetical protein YP_001742278.1 177632 R 439855 CDS YP_001742279.1 170681393 6143743 177787..180045 1 NC_010498.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 180045 fhuA 6143743 fhuA Escherichia coli SMS-3-5 ferrichrome outer membrane transporter YP_001742279.1 177787 D 439855 CDS YP_001742280.1 170682356 6145577 180096..180893 1 NC_010498.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 180893 fhuC 6145577 fhuC Escherichia coli SMS-3-5 iron-hydroxamate transporter ATP-binding subunit YP_001742280.1 180096 D 439855 CDS YP_001742281.1 170684223 6146555 180893..181783 1 NC_010498.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 181783 fhuD 6146555 fhuD Escherichia coli SMS-3-5 iron-hydroxamate transporter substrate-binding subunit YP_001742281.1 180893 D 439855 CDS YP_001742282.1 170683245 6143524 181780..183762 1 NC_010498.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 183762 fhuB 6143524 fhuB Escherichia coli SMS-3-5 iron-hydroxamate transporter permease subunit YP_001742282.1 181780 D 439855 CDS YP_001742283.1 170680366 6147468 complement(183797..185077) 1 NC_010498.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 185077 hemL 6147468 hemL Escherichia coli SMS-3-5 glutamate-1-semialdehyde aminotransferase YP_001742283.1 183797 R 439855 CDS YP_001742284.1 170682657 6144534 185302..186723 1 NC_010498.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 186723 clcA 6144534 clcA Escherichia coli SMS-3-5 chloride channel protein YP_001742284.1 185302 D 439855 CDS YP_001742285.1 170682180 6146864 186805..187149 1 NC_010498.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 187149 yadR 6146864 yadR Escherichia coli SMS-3-5 iron-sulfur cluster insertion protein ErpA YP_001742285.1 186805 D 439855 CDS YP_001742286.1 170681649 6146379 complement(187196..187819) 1 NC_010498.1 identified by match to protein family HMM PF03458; hypothetical protein 187819 6146379 EcSMS35_0169 Escherichia coli SMS-3-5 hypothetical protein YP_001742286.1 187196 R 439855 CDS YP_001742287.1 170681038 6145835 complement(187857..188657) 1 NC_010498.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 188657 btuF 6145835 btuF Escherichia coli SMS-3-5 vitamin B12-transporter protein BtuF YP_001742287.1 187857 R 439855 CDS YP_001742288.1 170681375 6145219 complement(188650..189348) 1 NC_010498.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 189348 mtnN 6145219 mtnN Escherichia coli SMS-3-5 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001742288.1 188650 R 439855 CDS YP_001742289.1 170681908 6145559 189432..190949 1 NC_010498.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 190949 dgt 6145559 dgt Escherichia coli SMS-3-5 deoxyguanosinetriphosphate triphosphohydrolase YP_001742289.1 189432 D 439855 CDS YP_001742290.1 170680398 6146103 191079..192503 1 NC_010498.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 192503 degP 6146103 degP Escherichia coli SMS-3-5 serine endoprotease YP_001742290.1 191079 D 439855 CDS YP_001742291.1 170679721 6144567 192658..193815 1 NC_010498.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 193815 cdaR 6144567 cdaR Escherichia coli SMS-3-5 carbohydrate diacid transcriptional activator CdaR YP_001742291.1 192658 D 439855 CDS YP_001742292.1 170683939 6143879 complement(193869..194255) 1 NC_010498.1 hypothetical protein 194255 6143879 EcSMS35_0175 Escherichia coli SMS-3-5 hypothetical protein YP_001742292.1 193869 R 439855 CDS YP_001742293.1 170682872 6143235 complement(194570..195394) 1 NC_010498.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 195394 dapD 6143235 dapD Escherichia coli SMS-3-5 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_001742293.1 194570 R 439855 CDS YP_001742294.1 170683624 6147085 complement(195425..198097) 1 NC_010498.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 198097 glnD 6147085 glnD Escherichia coli SMS-3-5 PII uridylyl-transferase YP_001742294.1 195425 R 439855 CDS YP_001742295.1 170684311 6142915 complement(198159..198953) 1 NC_010498.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 198953 map 6142915 map Escherichia coli SMS-3-5 methionine aminopeptidase YP_001742295.1 198159 R 439855 CDS YP_001742296.1 170679652 6143613 199321..200046 1 NC_010498.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 200046 rpsB 6143613 rpsB Escherichia coli SMS-3-5 30S ribosomal protein S2 YP_001742296.1 199321 D 439855 CDS YP_001742297.1 170681918 6143809 complement(199998..200162) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 200162 6143809 EcSMS35_0179 Escherichia coli SMS-3-5 hypothetical protein YP_001742297.1 199998 R 439855 CDS YP_001742298.1 170681184 6146113 200181..201032 1 NC_010498.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 201032 tsf 6146113 tsf Escherichia coli SMS-3-5 elongation factor Ts YP_001742298.1 200181 D 439855 CDS YP_001742299.1 170681680 6145368 201179..201904 1 NC_010498.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 201904 pyrH 6145368 pyrH Escherichia coli SMS-3-5 uridylate kinase YP_001742299.1 201179 D 439855 CDS YP_001742300.1 170683322 6145866 202054..202611 1 NC_010498.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 202611 frr 6145866 frr Escherichia coli SMS-3-5 ribosome recycling factor YP_001742300.1 202054 D 439855 CDS YP_001742301.1 170683853 6142607 202703..203899 1 NC_010498.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 203899 dxr 6142607 dxr Escherichia coli SMS-3-5 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001742301.1 202703 D 439855 CDS YP_001742302.1 170681254 6143147 204085..204846 1 NC_010498.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 204846 uppS 6143147 uppS Escherichia coli SMS-3-5 undecaprenyl pyrophosphate synthase YP_001742302.1 204085 D 439855 CDS YP_001742303.1 170682588 6145438 204859..205716 1 NC_010498.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 205716 cdsA 6145438 cdsA Escherichia coli SMS-3-5 CDP-diglyceride synthase YP_001742303.1 204859 D 439855 CDS YP_001742304.1 170683080 6146793 205728..207080 1 NC_010498.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 207080 rseP 6146793 rseP Escherichia coli SMS-3-5 zinc metallopeptidase RseP YP_001742304.1 205728 D 439855 CDS YP_001742305.1 170683955 6147297 207110..209542 1 NC_010498.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 209542 yaeT 6147297 yaeT Escherichia coli SMS-3-5 outer membrane protein assembly factor YaeT YP_001742305.1 207110 D 439855 CDS YP_001742306.1 170683286 6143252 209664..210149 1 NC_010498.1 identified by match to protein family HMM PF03938; periplasmic chaperone 210149 skp 6143252 skp Escherichia coli SMS-3-5 periplasmic chaperone YP_001742306.1 209664 D 439855 CDS YP_001742307.1 170683962 6147512 210153..211178 1 NC_010498.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 211178 lpxD 6147512 lpxD Escherichia coli SMS-3-5 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001742307.1 210153 D 439855 CDS YP_001742308.1 170680401 6143259 211283..211738 1 NC_010498.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 211738 fabZ 6143259 fabZ Escherichia coli SMS-3-5 (3R)-hydroxymyristoyl-ACP dehydratase YP_001742308.1 211283 D 439855 CDS YP_001742309.1 170679946 6144570 211742..212530 1 NC_010498.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 212530 lpxA 6144570 lpxA Escherichia coli SMS-3-5 UDP-N-acetylglucosamine acyltransferase YP_001742309.1 211742 D 439855 CDS YP_001742310.1 170681777 6144108 212530..213678 1 NC_010498.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 213678 lpxB 6144108 lpxB Escherichia coli SMS-3-5 lipid-A-disaccharide synthase YP_001742310.1 212530 D 439855 CDS YP_001742311.1 170680885 6145969 213675..214271 1 NC_010498.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 214271 rnhB 6145969 rnhB Escherichia coli SMS-3-5 ribonuclease HII YP_001742311.1 213675 D 439855 CDS YP_001742312.1 170682325 6145063 214308..217790 1 NC_010498.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 217790 dnaE 6145063 dnaE Escherichia coli SMS-3-5 DNA polymerase III subunit alpha YP_001742312.1 214308 D 439855 CDS YP_001742313.1 170682858 6146524 217803..218762 1 NC_010498.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 218762 accA 6146524 accA Escherichia coli SMS-3-5 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_001742313.1 217803 D 439855 CDS YP_001742314.1 170683659 6147071 218861..221002 1 NC_010498.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; lysine decarboxylase, constitutive 221002 ldcC1 6147071 ldcC1 Escherichia coli SMS-3-5 lysine decarboxylase, constitutive YP_001742314.1 218861 D 439855 CDS YP_001742315.1 170684191 6142951 221059..221448 1 NC_010498.1 identified by match to protein family HMM PF00903; hypothetical protein 221448 6142951 EcSMS35_0198 Escherichia coli SMS-3-5 hypothetical protein YP_001742315.1 221059 D 439855 CDS YP_001742316.1 170682716 6143492 221513..222811 1 NC_010498.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 222811 tilS 6143492 tilS Escherichia coli SMS-3-5 tRNA(Ile)-lysidine synthetase YP_001742316.1 221513 D 439855 CDS YP_001742317.1 170682964 6146924 complement(222860..223114) 1 NC_010498.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 223114 rof 6146924 rof Escherichia coli SMS-3-5 Rho-binding antiterminator YP_001742317.1 222860 R 439855 CDS YP_001742318.1 170681531 6147179 complement(223107..223307) 1 NC_010498.1 identified by match to protein family HMM PF06786; hypothetical protein 223307 6147179 EcSMS35_0201 Escherichia coli SMS-3-5 hypothetical protein YP_001742318.1 223107 R 439855 CDS YP_001742319.1 170682076 6145716 223473..224018 1 NC_010498.1 identified by match to protein family HMM PF07152; hypothetical protein 224018 6145716 EcSMS35_0202 Escherichia coli SMS-3-5 hypothetical protein YP_001742319.1 223473 D 439855 CDS YP_001742320.1 170680631 6146273 224015..224437 1 NC_010498.1 identified by match to protein family HMM PF00472; peptidyl-tRNA hydrolase domain protein 224437 6146273 EcSMS35_0203 Escherichia coli SMS-3-5 peptidyl-tRNA hydrolase domain protein YP_001742320.1 224015 D 439855 CDS YP_001742321.1 170680878 6144806 224451..225161 1 NC_010498.1 identified by match to protein family HMM PF04170; lipoprotein involved with copper homeostasis and adhesion 225161 cutF 6144806 cutF Escherichia coli SMS-3-5 lipoprotein involved with copper homeostasis and adhesion YP_001742321.1 224451 D 439855 CDS YP_001742322.1 170683602 6145056 complement(225317..226141) 1 NC_010498.1 hypothetical protein 226141 6145056 EcSMS35_0205 Escherichia coli SMS-3-5 hypothetical protein YP_001742322.1 225317 R 439855 CDS YP_001742323.1 170680577 6142892 complement(226194..227912) 1 NC_010498.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 227912 proS 6142892 proS Escherichia coli SMS-3-5 prolyl-tRNA synthetase YP_001742323.1 226194 R 439855 CDS YP_001742324.1 170683947 6144747 complement(228023..228730) 1 NC_010498.1 yaeB; identified by similarity to SP:P28634; match to protein family HMM PF01980; match to protein family HMM TIGR00104; hypothetical protein 228730 6144747 EcSMS35_0207 Escherichia coli SMS-3-5 hypothetical protein YP_001742324.1 228023 R 439855 CDS YP_001742325.1 170682244 6143243 complement(228727..229080) 1 NC_010498.1 outer membrane lipoprotein 229080 rcsF 6143243 rcsF Escherichia coli SMS-3-5 outer membrane lipoprotein YP_001742325.1 228727 R 439855 CDS YP_001742326.1 170680927 6146443 complement(229249..230064) 1 NC_010498.1 identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363; DL-methionine transporter substrate-binding subunit 230064 metQ 6146443 metQ Escherichia coli SMS-3-5 DL-methionine transporter substrate-binding subunit YP_001742326.1 229249 R 439855 CDS YP_001742327.1 170683569 6145108 complement(230104..230757) 1 NC_010498.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 230757 metI 6145108 metI Escherichia coli SMS-3-5 DL-methionine transporter permease subunit YP_001742327.1 230104 R 439855 CDS YP_001742328.1 170681875 6142860 complement(230750..231781) 1 NC_010498.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 231781 metN 6142860 metN Escherichia coli SMS-3-5 DL-methionine transporter ATP-binding subunit YP_001742328.1 230750 R 439855 CDS YP_001742329.1 170680208 6146069 231969..232541 1 NC_010498.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 232541 6146069 EcSMS35_0212 Escherichia coli SMS-3-5 D,D-heptose 1,7-bisphosphate phosphatase YP_001742329.1 231969 D 439855 CDS YP_001742330.1 170681897 6143645 238293..239096 1 NC_010498.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 239096 dkgB 6143645 dkgB Escherichia coli SMS-3-5 2,5-diketo-D-gluconate reductase B YP_001742330.1 238293 D 439855 CDS YP_001742331.1 170681248 6146092 complement(239093..240007) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 240007 6146092 EcSMS35_0221 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742331.1 239093 R 439855 CDS YP_001742332.1 170679930 6145432 240248..241048 1 NC_010498.1 identified by match to protein family HMM PF03372; hypothetical protein 241048 6145432 EcSMS35_0223 Escherichia coli SMS-3-5 hypothetical protein YP_001742332.1 240248 D 439855 CDS YP_001742333.1 170680535 6144092 241122..241892 1 NC_010498.1 identified by match to protein family HMM PF01209; match to protein family HMM PF08241; match to protein family HMM PF08242; UbiE/COQ5 family methlytransferase 241892 6144092 EcSMS35_0224 Escherichia coli SMS-3-5 UbiE/COQ5 family methlytransferase YP_001742333.1 241122 D 439855 CDS YP_001742334.1 170681258 6144705 complement(241941..243161) 1 NC_010498.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 243161 mltD 6144705 mltD Escherichia coli SMS-3-5 membrane-bound lytic murein transglycosylase D YP_001742334.1 241941 R 439855 CDS YP_001742335.1 170681858 6145442 complement(243371..244126) 1 NC_010498.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 244126 gloB 6145442 gloB Escherichia coli SMS-3-5 hydroxyacylglutathione hydrolase YP_001742335.1 243371 R 439855 CDS YP_001742336.1 170680838 6146052 244160..244882 1 NC_010498.1 identified by match to protein family HMM PF08241; putative methyltransferase 244882 6146052 EcSMS35_0228 Escherichia coli SMS-3-5 putative methyltransferase YP_001742336.1 244160 D 439855 CDS YP_001742337.1 170682534 6145015 complement(244879..245346) 1 NC_010498.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 245346 rnhA 6145015 rnhA Escherichia coli SMS-3-5 ribonuclease H YP_001742337.1 244879 R 439855 CDS YP_001742338.1 170683943 6146735 245402..246142 1 NC_010498.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 246142 dnaQ 6146735 dnaQ Escherichia coli SMS-3-5 DNA polymerase III subunit epsilon YP_001742338.1 245402 D 439855 CDS YP_001742339.1 170682248 6143660 complement(246450..247220) 1 NC_010498.1 identified by match to protein family HMM PF00795; hypothetical protein 247220 6143660 EcSMS35_0231 Escherichia coli SMS-3-5 hypothetical protein YP_001742339.1 246450 R 439855 CDS YP_001742340.1 170682383 6146447 247398..247847 1 NC_010498.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 247847 6146447 EcSMS35_0232 Escherichia coli SMS-3-5 C-lysozyme inhibitor YP_001742340.1 247398 D 439855 CDS YP_001742341.1 170681415 6146582 complement(247890..250334) 1 NC_010498.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 250334 fadE 6146582 fadE Escherichia coli SMS-3-5 acyl-CoA dehydrogenase YP_001742341.1 247890 R 439855 CDS YP_001742342.1 170681190 6145599 250574..251152 1 NC_010498.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 251152 gmhA 6145599 gmhA Escherichia coli SMS-3-5 phosphoheptose isomerase YP_001742342.1 250574 D 439855 CDS YP_001742343.1 170683986 6145374 251268..252035 1 NC_010498.1 identified by match to protein family HMM PF00310; glutamine amidotransferase, class II 252035 6145374 EcSMS35_0236 Escherichia coli SMS-3-5 glutamine amidotransferase, class II YP_001742343.1 251268 D 439855 CDS YP_001742344.1 170680694 6143284 complement(252006..252746) 1 NC_010498.1 yaFK; identified by match to protein family HMM PF06104; hypothetical protein 252746 6143284 EcSMS35_0235 Escherichia coli SMS-3-5 hypothetical protein YP_001742344.1 252006 R 439855 CDS YP_001742345.1 170684072 6145626 complement(253182..253442) 1 NC_010498.1 identified by similarity to SP:Q47150; match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin component DinJ 253442 dinJ 6145626 dinJ Escherichia coli SMS-3-5 addiction module antitoxin component DinJ YP_001742345.1 253182 R 439855 CDS YP_001742346.1 170683259 6143372 253652..254401 1 NC_010498.1 identified by match to protein family HMM PF00877; NlpC/P60 family protein 254401 6143372 EcSMS35_0239 Escherichia coli SMS-3-5 NlpC/P60 family protein YP_001742346.1 253652 D 439855 CDS YP_001742347.1 170683070 6147482 254577..255074 1 NC_010498.1 identified by similarity to GB:AAP15822.1; match to protein family HMM PF07605; hypothetical protein 255074 6147482 EcSMS35_0240 Escherichia coli SMS-3-5 hypothetical protein YP_001742347.1 254577 D 439855 CDS YP_001742348.1 170681922 6147287 complement(255186..257279) 1 NC_010498.1 identified by similarity to GB:CAH19113.1; match to protein family HMM PF00771; lateral flagellar export/assembly protein LfhA 257279 lfhA 6147287 lfhA Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfhA YP_001742348.1 255186 R 439855 CDS YP_001742349.1 170683079 6146118 complement(257263..258402) 1 NC_010498.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 258402 flhB 6146118 flhB Escherichia coli SMS-3-5 flagellar biosynthesis protein FlhB YP_001742349.1 257263 R 439855 CDS YP_001742350.1 170683764 6147296 complement(258392..259174) 1 NC_010498.1 identified by similarity to GB:CAH19115.1; match to protein family HMM PF01311; match to protein family HMM TIGR01400; lateral flagellar export/assembly protein LfiR 259174 lfiR 6147296 lfiR Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfiR YP_001742350.1 258392 R 439855 CDS YP_001742351.1 170683515 6143056 complement(259176..259448) 1 NC_010498.1 identified by similarity to GB:CAH19116.1; match to protein family HMM PF01313; lateral flagellar export/assembly protein LfiQ 259448 lfiQ 6143056 lfiQ Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfiQ YP_001742351.1 259176 R 439855 CDS YP_001742352.1 170684182 6142805 complement(259451..260203) 1 NC_010498.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 260203 fliP 6142805 fliP Escherichia coli SMS-3-5 flagellar biosynthesis protein FliP YP_001742352.1 259451 R 439855 CDS YP_001742353.1 170679793 6143483 complement(260200..260571) 1 NC_010498.1 identified by similarity to GB:CAH19118.1; match to protein family HMM PF01052; lateral flagellar export/assembly protein LfiN 260571 lfiN 6143483 lfiN Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfiN YP_001742353.1 260200 R 439855 CDS YP_001742354.1 170680472 6143953 complement(260564..261415) 1 NC_010498.1 identified by similarity to GB:CAH19119.1; match to protein family HMM PF01052; lateral flagellar export/assembly protein LfiM 261415 lfiM 6143953 lfiM Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfiM YP_001742354.1 260564 R 439855 CDS YP_001742355.1 170681447 6144641 261788..262774 1 NC_010498.1 identified by similarity to GB:CAH19120.1; match to protein family HMM PF00158; match to protein family HMM PF02954; lateral flagellar RpoN-interacting regulatory protein LafK 262774 lafK 6144641 lafK Escherichia coli SMS-3-5 lateral flagellar RpoN-interacting regulatory protein LafK YP_001742355.1 261788 D 439855 CDS YP_001742356.1 170682132 6145632 262789..263130 1 NC_010498.1 identified by similarity to GB:CAH19121.1; match to protein family HMM PF02049; lateral flagellar basal body component protein LfiE 263130 lfiE 6145632 lfiE Escherichia coli SMS-3-5 lateral flagellar basal body component protein LfiE YP_001742356.1 262789 D 439855 CDS YP_001742357.1 170682472 6146331 263135..264781 1 NC_010498.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; the Vibrio parahaemolyticus protein is associated with the lateral flagella; flagellar MS-ring protein 264781 fliF 6146331 fliF Escherichia coli SMS-3-5 flagellar MS-ring protein YP_001742357.1 263135 D 439855 CDS YP_001742358.1 170683129 6146671 264759..265769 1 NC_010498.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 265769 fliG 6146671 fliG Escherichia coli SMS-3-5 flagellar motor switch protein G YP_001742358.1 264759 D 439855 CDS YP_001742359.1 170682740 6147348 265772..266482 1 NC_010498.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 266482 fliH 6147348 fliH Escherichia coli SMS-3-5 flagellar assembly protein H YP_001742359.1 265772 D 439855 CDS YP_001742360.1 170682099 6146948 266475..267812 1 NC_010498.1 identified by similarity to GB:CAH19125.1; match to protein family HMM PF00006; match to protein family HMM TIGR01026; match to protein family HMM TIGR03496; lateral flagellar export/assembly protein LfiI 267812 lfiI 6146948 lfiI Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfiI YP_001742360.1 266475 D 439855 CDS YP_001742361.1 170679816 6146297 267815..268249 1 NC_010498.1 identified by similarity to GB:CAH19126.1; match to protein family HMM TIGR02473; lateral flagellar export/assembly protein LfiJ 268249 lfiJ 6146297 lfiJ Escherichia coli SMS-3-5 lateral flagellar export/assembly protein LfiJ YP_001742361.1 267815 D 439855 CDS YP_001742362.1 170681619 6143977 268252..268647 1 NC_010498.1 identified by similarity to GB:CAH19127.1; match to protein family HMM PF01467; match to protein family HMM PF06574; match to protein family HMM TIGR00125; cytidyltransferase-like protein 268647 6143977 EcSMS35_0255 Escherichia coli SMS-3-5 cytidyltransferase-like protein YP_001742362.1 268252 D 439855 CDS YP_001742363.1 170683506 6145804 complement(268659..268964) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 268964 6145804 EcSMS35_0256 Escherichia coli SMS-3-5 hypothetical protein YP_001742363.1 268659 R 439855 CDS YP_001742364.1 170680626 6142795 complement(269191..270012) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 270012 6142795 EcSMS35_0257 Escherichia coli SMS-3-5 hypothetical protein YP_001742364.1 269191 R 439855 CDS YP_001742365.1 170680272 6144801 complement(270338..272782) 1 NC_010498.1 identified by similarity to GB:CAH19128.1; match to protein family HMM PF00535; glycosyl transferase, group 2 family protein 272782 6144801 EcSMS35_0258 Escherichia coli SMS-3-5 glycosyl transferase, group 2 family protein YP_001742365.1 270338 R 439855 CDS YP_001742366.1 170683346 6144439 complement(272961..273890) 1 NC_010498.1 identified by similarity to GB:CAH19129.1; lateral flagellar associated protein LafV 273890 lafV 6144439 lafV Escherichia coli SMS-3-5 lateral flagellar associated protein LafV YP_001742366.1 272961 R 439855 CDS YP_001742367.1 170683864 6142632 complement(274018..274446) 1 NC_010498.1 identified by similarity to GB:CAH19130.1; lateral flagellar chaperone protein LfgN 274446 lfgN 6142632 lfgN Escherichia coli SMS-3-5 lateral flagellar chaperone protein LfgN YP_001742367.1 274018 R 439855 CDS YP_001742368.1 170682864 6143159 complement(274459..274737) 1 NC_010498.1 identified by similarity to GB:CAH19131.1; match to protein family HMM PF04316; lateral flagellar anti-sigma factor 28 protein LfgM 274737 lfgM 6143159 lfgM Escherichia coli SMS-3-5 lateral flagellar anti-sigma factor 28 protein LfgM YP_001742368.1 274459 R 439855 CDS YP_001742369.1 170682474 6147077 complement(274817..275554) 1 NC_010498.1 identified by similarity to GB:CAH19132.1; match to protein family HMM PF08666; match to protein family HMM TIGR03170; lateral flagellar P-ring addition protein LfgA 275554 lfgA 6147077 lfgA Escherichia coli SMS-3-5 lateral flagellar P-ring addition protein LfgA YP_001742369.1 274817 R 439855 CDS YP_001742370.1 170681292 6146673 275636..275971 1 NC_010498.1 identified by similarity to GB:CAH19133.1; match to protein family HMM TIGR01396; lateral flagellar rod protein LfgB 275971 lfgB 6146673 lfgB Escherichia coli SMS-3-5 lateral flagellar rod protein LfgB YP_001742370.1 275636 D 439855 CDS YP_001742371.1 170683008 6145476 275974..276405 1 NC_010498.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the lateral flagella; flagellar basal body rod protein FlgC 276405 flgC 6145476 flgC Escherichia coli SMS-3-5 flagellar basal body rod protein FlgC YP_001742371.1 275974 D 439855 CDS YP_001742372.1 170679856 6147224 276405..277118 1 NC_010498.1 identified by similarity to GB:CAH19135.1; match to protein family HMM PF03963; lateral flagellar rod protein LfgD 277118 lfgD 6147224 lfgD Escherichia coli SMS-3-5 lateral flagellar rod protein LfgD YP_001742372.1 276405 D 439855 CDS YP_001742373.1 170681389 6144018 277141..278343 1 NC_010498.1 identified by similarity to GB:CAH19136.1; match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM PF07559; lateral flagellar hook protein LfgE 278343 lfgE 6144018 lfgE Escherichia coli SMS-3-5 lateral flagellar hook protein LfgE YP_001742373.1 277141 D 439855 CDS YP_001742374.1 170680219 6145573 278343..279080 1 NC_010498.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 279080 flgF 6145573 flgF Escherichia coli SMS-3-5 flagellar basal body rod protein FlgF YP_001742374.1 278343 D 439855 CDS YP_001742375.1 170680582 6144385 279159..279944 1 NC_010498.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 279944 flgG 6144385 flgG Escherichia coli SMS-3-5 flagellar basal body rod protein FlgG YP_001742375.1 279159 D 439855 CDS YP_001742376.1 170682469 6144752 280027..280692 1 NC_010498.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; the Yersinia have 2 copies of flgH; flagellar basal body L-ring protein 280692 flgH 6144752 flgH Escherichia coli SMS-3-5 flagellar basal body L-ring protein YP_001742376.1 280027 D 439855 CDS YP_001742377.1 170683997 6146668 280692..281807 1 NC_010498.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 281807 flgI 6146668 flgI Escherichia coli SMS-3-5 flagellar basal body P-ring protein YP_001742377.1 280692 D 439855 CDS YP_001742378.1 170679695 6143296 281807..282106 1 NC_010498.1 identified by similarity to GB:CAH19141.1; lateral flagellar peptidoglycan hydrolase LfgJ 282106 lfgJ 6143296 lfgJ Escherichia coli SMS-3-5 lateral flagellar peptidoglycan hydrolase LfgJ YP_001742378.1 281807 D 439855 CDS YP_001742379.1 170680262 6143853 282527..283903 1 NC_010498.1 identified by similarity to GB:CAH19142.1; match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02492; lateral flagellar hook associated protein 1 283903 lfgK 6143853 lfgK Escherichia coli SMS-3-5 lateral flagellar hook associated protein 1 YP_001742379.1 282527 D 439855 CDS YP_001742380.1 170681553 6144429 283918..284847 1 NC_010498.1 identified by similarity to GB:CAH19143.1; match to protein family HMM PF00669; match to protein family HMM TIGR02550; lateral flagellar hook associated protein 3 284847 lfgL 6144429 lfgL Escherichia coli SMS-3-5 lateral flagellar hook associated protein 3 YP_001742380.1 283918 D 439855 CDS YP_001742381.1 170681968 6145738 284864..285841 1 NC_010498.1 identified by similarity to GB:CAH19144.1; lateral flagellar hook associated protein LafW 285841 lafW 6145738 lafW Escherichia coli SMS-3-5 lateral flagellar hook associated protein LafW YP_001742381.1 284864 D 439855 CDS YP_001742382.1 170682839 6146164 complement(285900..286793) 1 NC_010498.1 identified by similarity to GB:CAH19147.1; match to protein family HMM PF00486; lateral flagellar transmembrane regulator LafZ 286793 lafZ 6146164 lafZ Escherichia coli SMS-3-5 lateral flagellar transmembrane regulator LafZ YP_001742382.1 285900 R 439855 CDS YP_001742383.1 170683491 6147050 287229..288143 1 NC_010498.1 identified by similarity to GB:CAH19148.1; match to protein family HMM PF00669; match to protein family HMM PF00700; lateral flagellar flagellin LafA 288143 lafA 6147050 lafA Escherichia coli SMS-3-5 lateral flagellar flagellin LafA YP_001742383.1 287229 D 439855 CDS YP_001742384.1 170680645 6142780 288349..289665 1 NC_010498.1 identified by similarity to GB:CAH19149.1; match to protein family HMM PF02465; match to protein family HMM PF07195; lateral flagellar hook associated protein 2 289665 lafB 6142780 lafB Escherichia coli SMS-3-5 lateral flagellar hook associated protein 2 YP_001742384.1 288349 D 439855 CDS YP_001742385.1 170680841 6144820 289688..290080 1 NC_010498.1 identified by similarity to GB:CAH19150.1; match to protein family HMM PF02561; match to protein family HMM TIGR00208; lateral flagellar chaperone protein LafC 290080 lafC 6144820 lafC Escherichia coli SMS-3-5 lateral flagellar chaperone protein LafC YP_001742385.1 289688 D 439855 CDS YP_001742386.1 170681682 6145018 290085..290396 1 NC_010498.1 identified by similarity to GB:CAH19151.1; lateral flagellar chaperone protein LafD 290396 lafD 6145018 lafD Escherichia coli SMS-3-5 lateral flagellar chaperone protein LafD YP_001742386.1 290085 D 439855 CDS YP_001742387.1 170682509 6145868 290393..291454 1 NC_010498.1 identified by similarity to GB:CAH19152.1; match to protein family HMM PF02120; lateral flagellar hook length control protein LafE 291454 lafE 6145868 lafE Escherichia coli SMS-3-5 lateral flagellar hook length control protein LafE YP_001742387.1 290393 D 439855 CDS YP_001742388.1 170682924 6146709 291462..291929 1 NC_010498.1 identified by similarity to GB:CAH19153.1; match to protein family HMM PF03748; lateral flagellar basal body-associated protein LafF 291929 lafF 6146709 lafF Escherichia coli SMS-3-5 lateral flagellar basal body-associated protein LafF YP_001742388.1 291462 D 439855 CDS YP_001742389.1 170682912 6147138 291949..292668 1 NC_010498.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 292668 lafS 6147138 lafS Escherichia coli SMS-3-5 flagellar biosynthesis sigma factor YP_001742389.1 291949 D 439855 CDS YP_001742390.1 170681048 6147126 292681..293544 1 NC_010498.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 293544 lafT 6147126 lafT Escherichia coli SMS-3-5 flagellar motor protein MotA YP_001742390.1 292681 D 439855 CDS YP_001742391.1 170681840 6145229 293547..294470 1 NC_010498.1 identified by similarity to GB:CAH19156.1; match to protein family HMM PF00691; hypothetical protein 294470 lafU 6145229 lafU Escherichia coli SMS-3-5 hypothetical protein YP_001742391.1 293547 D 439855 CDS YP_001742392.1 170679693 6146033 294541..295596 1 NC_010498.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 295596 dinB 6146033 dinB Escherichia coli SMS-3-5 DNA polymerase IV YP_001742392.1 294541 D 439855 CDS YP_001742393.1 170683148 6143851 295648..295941 1 NC_010498.1 identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; putative antitoxin of the YafO-YafN toxin-antitoxin system 295941 6143851 EcSMS35_0286 Escherichia coli SMS-3-5 putative antitoxin of the YafO-YafN toxin-antitoxin system YP_001742393.1 295648 D 439855 CDS YP_001742394.1 170682780 6143085 296353..296805 1 NC_010498.1 yafP; identified by match to protein family HMM PF00583; hypothetical protein 296805 6143085 EcSMS35_0288 Escherichia coli SMS-3-5 hypothetical protein YP_001742394.1 296353 D 439855 CDS YP_001742395.1 170682374 6146989 296996..298135 1 NC_010498.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 298135 6146989 EcSMS35_0289 Escherichia coli SMS-3-5 hypothetical protein YP_001742395.1 296996 D 439855 CDS YP_001742396.1 170684096 6146573 298132..298746 1 NC_010498.1 similar to release factor 1 and 2; peptide chain release factor-like protein 298746 prfH 6146573 prfH Escherichia coli SMS-3-5 peptide chain release factor-like protein YP_001742396.1 298132 D 439855 CDS YP_001742397.1 170683224 6143396 complement(298803..300260) 1 NC_010498.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01893; aminoacyl-histidine dipeptidase 300260 pepD 6143396 pepD Escherichia coli SMS-3-5 aminoacyl-histidine dipeptidase YP_001742397.1 298803 R 439855 CDS YP_001742398.1 170680344 6147445 300521..300979 1 NC_010498.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 300979 gpt 6147445 gpt Escherichia coli SMS-3-5 xanthine-guanine phosphoribosyltransferase YP_001742398.1 300521 D 439855 CDS YP_001742399.1 170681335 6144512 301071..302315 1 NC_010498.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 302315 frsA 6144512 frsA Escherichia coli SMS-3-5 fermentation/respiration switch protein YP_001742399.1 301071 D 439855 CDS YP_001742400.1 170680819 6145519 302373..302774 1 NC_010498.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 302774 crl 6145519 crl Escherichia coli SMS-3-5 DNA-binding transcriptional regulator Crl YP_001742400.1 302373 D 439855 CDS YP_001742401.1 170681243 6144995 complement(302813..303868) 1 NC_010498.1 identified by match to protein family HMM PF00267; outer membrane phosphoporin protein E 303868 phoE 6144995 phoE Escherichia coli SMS-3-5 outer membrane phosphoporin protein E YP_001742401.1 302813 R 439855 CDS YP_001742402.1 170681970 6145427 304156..305259 1 NC_010498.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 305259 proB 6145427 proB Escherichia coli SMS-3-5 gamma-glutamyl kinase YP_001742402.1 304156 D 439855 CDS YP_001742403.1 170682591 6146166 305271..306524 1 NC_010498.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 306524 proA 6146166 proA Escherichia coli SMS-3-5 gamma-glutamyl phosphate reductase YP_001742403.1 305271 D 439855 CDS YP_001742404.1 170681995 6143653 306879..308063 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 308063 6143653 EcSMS35_0299 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001742404.1 306879 D 439855 CDS YP_001742405.1 170683965 6146191 308165..309130 1 NC_010498.1 identified by similarity to GB:BAA16614.1; hypothetical protein 309130 6146191 EcSMS35_0300 Escherichia coli SMS-3-5 hypothetical protein YP_001742405.1 308165 D 439855 CDS YP_001742406.1 170681416 6143262 complement(309610..310773) 1 NC_010498.1 identified by similarity to GB:CAD73582.1; hypothetical protein 310773 6143262 EcSMS35_0301 Escherichia coli SMS-3-5 hypothetical protein YP_001742406.1 309610 R 439855 CDS YP_001742407.1 170680899 6145600 complement(310770..311219) 1 NC_010498.1 identified by match to protein family HMM PF00072; response regulator 311219 6145600 EcSMS35_0302 Escherichia coli SMS-3-5 response regulator YP_001742407.1 310770 R 439855 CDS YP_001742408.1 170682597 6145078 complement(311216..314491) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 314491 6145078 EcSMS35_0303 Escherichia coli SMS-3-5 hypothetical protein YP_001742408.1 311216 R 439855 CDS YP_001742409.1 170681984 6146802 314956..315267 1 NC_010498.1 identified by match to protein family HMM PF01527; IS911 transposase orfA 315267 6146802 EcSMS35_0304 Escherichia coli SMS-3-5 IS911 transposase orfA YP_001742409.1 314956 D 439855 CDS YP_001742410.1 170683982 6146180 315387..316133 1 NC_010498.1 identified by match to protein family HMM PF00665; IS911 transposase orfB 316133 6146180 EcSMS35_0305 Escherichia coli SMS-3-5 IS911 transposase orfB YP_001742410.1 315387 D 439855 CDS YP_001742411.1 170680057 6142595 316666..317124 1 NC_010498.1 identified by match to protein family HMM PF03230; antirestriction protein 317124 6142595 EcSMS35_0307 Escherichia coli SMS-3-5 antirestriction protein YP_001742411.1 316666 D 439855 CDS YP_001742412.1 170684134 6144221 317136..317615 1 NC_010498.1 identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 317615 6144221 EcSMS35_0308 Escherichia coli SMS-3-5 RadC family DNA repair protein YP_001742412.1 317136 D 439855 CDS YP_001742413.1 170680749 6143434 317624..317845 1 NC_010498.1 identified by similarity to GB:ABB61177.1; match to protein family HMM PF06174; hypothetical protein 317845 6143434 EcSMS35_0309 Escherichia coli SMS-3-5 hypothetical protein YP_001742413.1 317624 D 439855 CDS YP_001742414.1 170680734 6144924 317865..318182 1 NC_010498.1 identified by similarity to SP:P52141; match to protein family HMM PF06154; putative antitoxin module of toxin-antitoxin system 318182 6144924 EcSMS35_0310 Escherichia coli SMS-3-5 putative antitoxin module of toxin-antitoxin system YP_001742414.1 317865 D 439855 CDS YP_001742415.1 170681027 6144909 318634..318771 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 318771 6144909 EcSMS35_0311 Escherichia coli SMS-3-5 hypothetical protein YP_001742415.1 318634 D 439855 CDS YP_001742416.1 170681475 6145208 318976..319149 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 319149 6145208 EcSMS35_0312 Escherichia coli SMS-3-5 hypothetical protein YP_001742416.1 318976 D 439855 CDS YP_001742417.1 170679639 6145660 319364..319978 1 NC_010498.1 identified by match to protein family HMM PF07274; hypothetical protein 319978 6145660 EcSMS35_0313 Escherichia coli SMS-3-5 hypothetical protein YP_001742417.1 319364 D 439855 CDS YP_001742418.1 170683678 6143796 320437..320577 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 320577 6143796 EcSMS35_0314 Escherichia coli SMS-3-5 hypothetical protein YP_001742418.1 320437 D 439855 CDS YP_001742419.1 170684180 6142970 complement(320869..321579) 1 NC_010498.1 hypothetical protein 321579 6142970 EcSMS35_0315 Escherichia coli SMS-3-5 hypothetical protein YP_001742419.1 320869 R 439855 CDS YP_001742420.1 170682359 6143481 complement(321548..323191) 1 NC_010498.1 hypothetical protein 323191 6143481 EcSMS35_0316 Escherichia coli SMS-3-5 hypothetical protein YP_001742420.1 321548 R 439855 CDS YP_001742421.1 170682860 6146558 complement(323181..325706) 1 NC_010498.1 hypothetical protein 325706 6146558 EcSMS35_0317 Escherichia coli SMS-3-5 hypothetical protein YP_001742421.1 323181 R 439855 CDS YP_001742422.1 170680987 6147073 complement(325732..326400) 1 NC_010498.1 hypothetical protein 326400 6147073 EcSMS35_0318 Escherichia coli SMS-3-5 hypothetical protein YP_001742422.1 325732 R 439855 CDS YP_001742423.1 170680204 6145168 complement(326458..327045) 1 NC_010498.1 fimbrillin MatB 327045 matB 6145168 matB Escherichia coli SMS-3-5 fimbrillin MatB YP_001742423.1 326458 R 439855 CDS YP_001742424.1 170683376 6144370 complement(327120..327662) 1 NC_010498.1 identified by match to protein family HMM PF00196; fimbrillin MatA 327662 matA 6144370 matA Escherichia coli SMS-3-5 fimbrillin MatA YP_001742424.1 327120 R 439855 CDS YP_001742425.1 170684094 6142662 complement(328115..328339) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 328339 6142662 EcSMS35_0321 Escherichia coli SMS-3-5 hypothetical protein YP_001742425.1 328115 R 439855 CDS YP_001742426.1 170683468 6143394 328398..328517 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 328517 6143394 EcSMS35_0322 Escherichia coli SMS-3-5 hypothetical protein YP_001742426.1 328398 D 439855 CDS YP_001742427.1 170681769 6142757 complement(328746..328886) 1 NC_010498.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 328886 rpmJ 6142757 rpmJ Escherichia coli SMS-3-5 50S ribosomal protein L36 YP_001742427.1 328746 R 439855 CDS YP_001742428.1 170681094 6145961 complement(328886..329149) 1 NC_010498.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 329149 rpmE2 6145961 rpmE2 Escherichia coli SMS-3-5 50S ribosomal protein L31 type B YP_001742428.1 328886 R 439855 CDS YP_001742429.1 170680739 6145276 complement(330089..331231) 1 NC_010498.1 identified by match to protein family HMM PF00724; oxidoreductase, FAD/FMN-binding 331231 6145276 EcSMS35_0325 Escherichia coli SMS-3-5 oxidoreductase, FAD/FMN-binding YP_001742429.1 330089 R 439855 CDS YP_001742430.1 170680060 6144914 complement(331476..332396) 1 NC_010498.1 identified by similarity to GB:AAZ61189.1; hypothetical protein 332396 6144914 EcSMS35_0326 Escherichia coli SMS-3-5 hypothetical protein YP_001742430.1 331476 R 439855 CDS YP_001742431.1 170683778 6144224 332553..333479 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 333479 6144224 EcSMS35_0327 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742431.1 332553 D 439855 CDS YP_001742432.1 170683135 6143070 333679..334572 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 334572 6143070 EcSMS35_0328 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742432.1 333679 D 439855 CDS YP_001742433.1 170682774 6147354 complement(334603..335592) 1 NC_010498.1 identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 335592 6147354 EcSMS35_0329 Escherichia coli SMS-3-5 aldo/keto reductase family oxidoreductase YP_001742433.1 334603 R 439855 CDS YP_001742434.1 170682093 6146983 complement(335619..336470) 1 NC_010498.1 identified by similarity to GB:ABB80491.1; match to protein family HMM PF00248; organophosphate reductase 336470 6146983 EcSMS35_0330 Escherichia coli SMS-3-5 organophosphate reductase YP_001742434.1 335619 R 439855 CDS YP_001742435.1 170680117 6146291 337036..341289 1 NC_010498.1 identified by match to protein family HMM PF02369; putative invasin 341289 6146291 EcSMS35_0331 Escherichia coli SMS-3-5 putative invasin YP_001742435.1 337036 D 439855 CDS YP_001742436.1 170680656 6144282 complement(341410..342267) 1 NC_010498.1 identified by match to protein family HMM PF00165; match to protein family HMM PF06445; AraC family transcriptional regulator 342267 6144282 EcSMS35_0332 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001742436.1 341410 R 439855 CDS YP_001742437.1 170683890 6144831 342515..343384 1 NC_010498.1 identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 343384 6144831 EcSMS35_0333 Escherichia coli SMS-3-5 aldo/keto reductase family oxidoreductase YP_001742437.1 342515 D 439855 CDS YP_001742438.1 170681931 6143185 complement(343546..344139) 1 NC_010498.1 identified by match to protein family HMM PF04224; hypothetical protein 344139 6143185 EcSMS35_0334 Escherichia coli SMS-3-5 hypothetical protein YP_001742438.1 343546 R 439855 CDS YP_001742439.1 170682857 6146127 complement(344151..344387) 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 344387 6146127 EcSMS35_0335 Escherichia coli SMS-3-5 hypothetical protein YP_001742439.1 344151 R 439855 CDS YP_001742440.1 170680932 6147070 complement(344496..345821) 1 NC_010498.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 345821 6147070 EcSMS35_0336 Escherichia coli SMS-3-5 pyridine nucleotide-disulfide oxidoreductase YP_001742440.1 344496 R 439855 CDS YP_001742441.1 170681796 6145113 346048..346902 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 346902 6145113 EcSMS35_0337 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001742441.1 346048 D 439855 CDS YP_001742442.1 170679917 6145989 347428..348147 1 NC_010498.1 identified by match to protein family HMM PF02754; hypothetical protein 348147 6145989 EcSMS35_0338 Escherichia coli SMS-3-5 hypothetical protein YP_001742442.1 347428 D 439855 CDS YP_001742443.1 170681838 6144079 348158..349585 1 NC_010498.1 identified by match to protein family HMM PF02589; match to protein family HMM TIGR00273; iron-sulfur cluster binding protein 349585 6144079 EcSMS35_0339 Escherichia coli SMS-3-5 iron-sulfur cluster binding protein YP_001742443.1 348158 D 439855 CDS YP_001742444.1 170679990 6146031 349578..350273 1 NC_010498.1 identified by match to protein family HMM PF02589; hypothetical protein 350273 6146031 EcSMS35_0340 Escherichia coli SMS-3-5 hypothetical protein YP_001742444.1 349578 D 439855 CDS YP_001742445.1 170681827 6144152 complement(350347..350544) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 350544 6144152 EcSMS35_0341 Escherichia coli SMS-3-5 hypothetical protein YP_001742445.1 350347 R 439855 CDS YP_001742446.1 170681227 6146020 complement(350805..352493) 1 NC_010498.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 352493 betA 6146020 betA Escherichia coli SMS-3-5 choline dehydrogenase YP_001742446.1 350805 R 439855 CDS YP_001742447.1 170681572 6145411 complement(352507..353979) 1 NC_010498.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 353979 betB 6145411 betB Escherichia coli SMS-3-5 betaine aldehyde dehydrogenase YP_001742447.1 352507 R 439855 CDS YP_001742448.1 170680533 6145757 complement(353993..354580) 1 NC_010498.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 354580 betI 6145757 betI Escherichia coli SMS-3-5 transcriptional regulator BetI YP_001742448.1 353993 R 439855 CDS YP_001742449.1 170680230 6144703 354709..356742 1 NC_010498.1 proton-motive-force-driven choline transporter; choline transport protein BetT 356742 betT 6144703 betT Escherichia coli SMS-3-5 choline transport protein BetT YP_001742449.1 354709 D 439855 CDS YP_001742450.1 170679658 6144396 357618..358706 1 NC_010498.1 identified by match to protein family HMM PF00196; match to protein family HMM PF00563; LuxR-family transcriptional regulator 358706 6144396 EcSMS35_0346 Escherichia coli SMS-3-5 LuxR-family transcriptional regulator YP_001742450.1 357618 D 439855 CDS YP_001742451.1 170683566 6143816 complement(358748..359680) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 359680 6143816 EcSMS35_0347 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742451.1 358748 R 439855 CDS YP_001742452.1 170682594 6142857 complement(359772..360269) 1 NC_010498.1 identified by match to protein family HMM PF06496; hypothetical protein 360269 6142857 EcSMS35_0348 Escherichia coli SMS-3-5 hypothetical protein YP_001742452.1 359772 R 439855 CDS YP_001742453.1 170682347 6146799 360527..361132 1 NC_010498.1 identified by match to protein family HMM PF00023; ankyrin repeat-containing protein 361132 6146799 EcSMS35_0349 Escherichia coli SMS-3-5 ankyrin repeat-containing protein YP_001742453.1 360527 D 439855 CDS YP_001742454.1 170681656 6146546 361172..362035 1 NC_010498.1 hypothetical protein 362035 6146546 EcSMS35_0350 Escherichia coli SMS-3-5 hypothetical protein YP_001742454.1 361172 D 439855 CDS YP_001742455.1 170683991 6145842 362025..363572 1 NC_010498.1 identified by match to protein family HMM PF06263; acyl-CoA synthetase 363572 6145842 EcSMS35_0351 Escherichia coli SMS-3-5 acyl-CoA synthetase YP_001742455.1 362025 D 439855 CDS YP_001742456.1 170682165 6143289 363572..364990 1 NC_010498.1 identified by match to protein family HMM PF06545; hypothetical protein 364990 6143289 EcSMS35_0352 Escherichia coli SMS-3-5 hypothetical protein YP_001742456.1 363572 D 439855 CDS YP_001742457.1 170682847 6146364 365085..366035 1 NC_010498.1 identified by match to protein family HMM PF00696; putative carbamate kinase 366035 6146364 EcSMS35_0353 Escherichia coli SMS-3-5 putative carbamate kinase YP_001742457.1 365085 D 439855 CDS YP_001742458.1 170681260 6147060 366045..367427 1 NC_010498.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 367427 6147060 EcSMS35_0354 Escherichia coli SMS-3-5 putative deaminase YP_001742458.1 366045 D 439855 CDS YP_001742459.1 170680074 6145444 367651..367788 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 367788 6145444 EcSMS35_0355 Escherichia coli SMS-3-5 hypothetical protein YP_001742459.1 367651 D 439855 CDS YP_001742460.1 170680738 6144238 367804..368853 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 368853 6144238 EcSMS35_0356 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001742460.1 367804 D 439855 CDS YP_001742461.1 170680386 6144913 369096..369911 1 NC_010498.1 hypothetical protein 369911 6144913 EcSMS35_0357 Escherichia coli SMS-3-5 hypothetical protein YP_001742461.1 369096 D 439855 CDS YP_001742462.1 170683132 6143686 complement(370587..371219) 1 NC_010498.1 identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; putative homoserine/threonine efflux protein 371219 6143686 EcSMS35_0359 Escherichia coli SMS-3-5 putative homoserine/threonine efflux protein YP_001742462.1 370587 R 439855 CDS YP_001742463.1 170683473 6147351 371405..371680 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 371680 6147351 EcSMS35_0360 Escherichia coli SMS-3-5 hypothetical protein YP_001742463.1 371405 D 439855 CDS YP_001742464.1 170679785 6142762 371707..371829 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 371829 6142762 EcSMS35_0362 Escherichia coli SMS-3-5 hypothetical protein YP_001742464.1 371707 D 439855 CDS YP_001742465.1 170684111 6143945 complement(371781..373367) 1 NC_010498.1 identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF06506; match to protein family HMM TIGR02329; propionate catabolism operon regulatory protein PrpR 373367 prpR 6143945 prpR Escherichia coli SMS-3-5 propionate catabolism operon regulatory protein PrpR YP_001742465.1 371781 R 439855 CDS YP_001742466.1 170679897 6143411 373606..374496 1 NC_010498.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 374496 prpB 6143411 prpB Escherichia coli SMS-3-5 2-methylisocitrate lyase YP_001742466.1 373606 D 439855 CDS YP_001742467.1 170680874 6144059 374541..375710 1 NC_010498.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 375710 prpC 6144059 prpC Escherichia coli SMS-3-5 methylcitrate synthase YP_001742467.1 374541 D 439855 CDS YP_001742468.1 170681387 6145052 375744..377195 1 NC_010498.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 377195 prpD 6145052 prpD Escherichia coli SMS-3-5 2-methylcitrate dehydratase YP_001742468.1 375744 D 439855 CDS YP_001742469.1 170679862 6145571 377235..379121 1 NC_010498.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 379121 prpE 6145571 prpE Escherichia coli SMS-3-5 propionyl-CoA synthetase YP_001742469.1 377235 D 439855 CDS YP_001742470.1 170680347 6144024 379358..380617 1 NC_010498.1 identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800; cytosine permease 380617 codB 6144024 codB Escherichia coli SMS-3-5 cytosine permease YP_001742470.1 379358 D 439855 CDS YP_001742471.1 170683266 6144515 380607..381890 1 NC_010498.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 381890 codA 6144515 codA Escherichia coli SMS-3-5 cytosine deaminase YP_001742471.1 380607 D 439855 CDS YP_001742472.1 170683944 6147491 complement(382023..382922) 1 NC_010498.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 382922 cynR 6147491 cynR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator CynR YP_001742472.1 382023 R 439855 CDS YP_001742473.1 170682028 6143240 383032..383691 1 NC_010498.1 identified by match to protein family HMM PF00484; carbonic anhydrase 383691 cynT 6143240 cynT Escherichia coli SMS-3-5 carbonic anhydrase YP_001742473.1 383032 D 439855 CDS YP_001742474.1 170683024 6146225 383722..384192 1 NC_010498.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 384192 cynS 6146225 cynS Escherichia coli SMS-3-5 cyanate hydratase YP_001742474.1 383722 D 439855 CDS YP_001742475.1 170684294 6147240 384225..385379 1 NC_010498.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter 385379 cynX 6147240 cynX Escherichia coli SMS-3-5 putative cyanate transporter YP_001742475.1 384225 D 439855 CDS YP_001742476.1 170682300 6143596 complement(385467..386087) 1 NC_010498.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 386087 lacA 6143596 lacA Escherichia coli SMS-3-5 galactoside O-acetyltransferase YP_001742476.1 385467 R 439855 CDS YP_001742477.1 170680767 6146499 complement(386144..387397) 1 NC_010498.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 387397 lacY 6146499 lacY Escherichia coli SMS-3-5 galactoside permease YP_001742477.1 386144 R 439855 CDS YP_001742478.1 170681400 6144942 complement(387449..390523) 1 NC_010498.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 390523 lacZ 6144942 lacZ Escherichia coli SMS-3-5 beta-D-galactosidase YP_001742478.1 387449 R 439855 CDS YP_001742479.1 170679780 6145584 complement(390646..391728) 1 NC_010498.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 391728 lacI 6145584 lacI Escherichia coli SMS-3-5 lac repressor YP_001742479.1 390646 R 439855 CDS YP_001742480.1 170680396 6143939 complement(391805..392650) 1 NC_010498.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 392650 mhpR 6143939 mhpR Escherichia coli SMS-3-5 DNA-binding transcriptional activator MhpR YP_001742480.1 391805 R 439855 CDS YP_001742481.1 170683478 6144565 392829..394493 1 NC_010498.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 394493 mhpA 6144565 mhpA Escherichia coli SMS-3-5 3-(3-hydroxyphenyl)propionate hydroxylase YP_001742481.1 392829 D 439855 CDS YP_001742482.1 170684010 6142767 394495..395439 1 NC_010498.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 395439 mhpB 6142767 mhpB Escherichia coli SMS-3-5 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_001742482.1 394495 D 439855 CDS YP_001742483.1 170683466 6143309 395457..396323 1 NC_010498.1 identified by match to protein family HMM PF00561; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 396323 mhpC 6143309 mhpC Escherichia coli SMS-3-5 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_001742483.1 395457 D 439855 CDS YP_001742484.1 170684013 6142755 396333..397142 1 NC_010498.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 397142 mhpD 6142755 mhpD Escherichia coli SMS-3-5 2-keto-4-pentenoate hydratase YP_001742484.1 396333 D 439855 CDS YP_001742485.1 170682483 6143312 397139..398089 1 NC_010498.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 398089 mhpF 6143312 mhpF Escherichia coli SMS-3-5 acetaldehyde dehydrogenase YP_001742485.1 397139 D 439855 CDS YP_001742486.1 170682868 6146682 398086..399099 1 NC_010498.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 399099 mhpE 6146682 mhpE Escherichia coli SMS-3-5 4-hydroxy-2-ketovalerate aldolase YP_001742486.1 398086 D 439855 CDS YP_001742487.1 170680668 6147081 399275..400486 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00895; putative 3-hydroxyphenylpropionic transporter MhpT 400486 6147081 EcSMS35_0384 Escherichia coli SMS-3-5 putative 3-hydroxyphenylpropionic transporter MhpT YP_001742487.1 399275 D 439855 CDS YP_001742488.1 170683415 6144843 400588..401127 1 NC_010498.1 hypothetical protein 401127 6144843 EcSMS35_0385 Escherichia coli SMS-3-5 hypothetical protein YP_001742488.1 400588 D 439855 CDS YP_001742489.1 170684242 6142701 complement(401252..402085) 1 NC_010498.1 identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821; S-formylglutathione hydrolase 402085 fghA2 6142701 fghA2 Escherichia coli SMS-3-5 S-formylglutathione hydrolase YP_001742489.1 401252 R 439855 CDS YP_001742490.1 170682377 6143543 complement(402177..403286) 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02818; S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase 403286 adhC 6143543 adhC Escherichia coli SMS-3-5 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase YP_001742490.1 402177 R 439855 CDS YP_001742491.1 170680784 6146576 complement(403321..403596) 1 NC_010498.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 403596 6146576 EcSMS35_0388 Escherichia coli SMS-3-5 regulator protein FrmR YP_001742491.1 403321 R 439855 CDS YP_001742492.1 170681412 6144959 complement(403781..404554) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 404554 6144959 EcSMS35_0389 Escherichia coli SMS-3-5 hypothetical protein YP_001742492.1 403781 R 439855 CDS YP_001742493.1 170679736 6145596 complement(404556..404996) 1 NC_010498.1 identified by match to protein family HMM PF00132; putative acyltransferase 404996 6145596 EcSMS35_0390 Escherichia coli SMS-3-5 putative acyltransferase YP_001742493.1 404556 R 439855 CDS YP_001742494.1 170680221 6143894 complement(405115..406311) 1 NC_010498.1 identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein 406311 6143894 EcSMS35_0391 Escherichia coli SMS-3-5 glycosyl transferase, group 2 family protein YP_001742494.1 405115 R 439855 CDS YP_001742495.1 170680287 6144387 complement(406321..406992) 1 NC_010498.1 identified by match to protein family HMM PF02585; putative GlcNAc-PI de-N-acetylase 406992 6144387 EcSMS35_0392 Escherichia coli SMS-3-5 putative GlcNAc-PI de-N-acetylase YP_001742495.1 406321 R 439855 CDS YP_001742496.1 170680834 6144455 complement(407430..407609) 1 NC_010498.1 hypothetical protein 407609 6144455 EcSMS35_0393 Escherichia coli SMS-3-5 hypothetical protein YP_001742496.1 407430 R 439855 CDS YP_001742497.1 170684058 6145011 407608..408570 1 NC_010498.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 408570 tauA 6145011 tauA Escherichia coli SMS-3-5 taurine transporter substrate binding subunit YP_001742497.1 407608 D 439855 CDS YP_001742498.1 170679852 6143357 408584..409351 1 NC_010498.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 409351 tauB 6143357 tauB Escherichia coli SMS-3-5 taurine transporter ATP-binding subunit YP_001742498.1 408584 D 439855 CDS YP_001742499.1 170683056 6144014 409348..410175 1 NC_010498.1 identified by match to protein family HMM PF00528; taurine transporter subunit 410175 tauC 6144014 tauC Escherichia coli SMS-3-5 taurine transporter subunit YP_001742499.1 409348 D 439855 CDS YP_001742500.1 170683535 6147272 410172..411023 1 NC_010498.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 411023 tauD 6147272 tauD Escherichia coli SMS-3-5 taurine dioxygenase YP_001742500.1 410172 D 439855 CDS YP_001742501.1 170680798 6142825 complement(411063..412037) 1 NC_010498.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 412037 hemB 6142825 hemB Escherichia coli SMS-3-5 delta-aminolevulinic acid dehydratase YP_001742501.1 411063 R 439855 CDS YP_001742502.1 170682512 6144974 412563..413420 1 NC_010498.1 yaiT; hypothetical protein 413420 6144974 EcSMS35_0400 Escherichia coli SMS-3-5 hypothetical protein YP_001742502.1 412563 D 439855 CDS YP_001742503.1 170682518 6146712 complement(413260..414165) 1 NC_010498.1 identified by match to protein family HMM PF00665; IS2 transposase orfB 414165 6146712 EcSMS35_0399 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001742503.1 413260 R 439855 CDS YP_001742504.1 170682327 6146719 complement(414123..414533) 1 NC_010498.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 414533 6146719 EcSMS35_0401 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001742504.1 414123 R 439855 CDS YP_001742505.1 170683055 6146526 414664..416808 1 NC_010498.1 identified by match to protein family HMM PF03797; match to protein family HMM TIGR01414; outer membrane autotransporter 416808 6146526 EcSMS35_0402 Escherichia coli SMS-3-5 outer membrane autotransporter YP_001742505.1 414664 D 439855 CDS YP_001742506.1 170679630 6147271 416894..417517 1 NC_010498.1 identified by Glimmer3; putative; putative DNA-binding transcriptional regulator 417517 6147271 EcSMS35_0403 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001742506.1 416894 D 439855 CDS YP_001742507.1 170680606 6143787 complement(417518..418675) 1 NC_010498.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 418675 ampH 6143787 ampH Escherichia coli SMS-3-5 beta-lactam binding protein AmpH YP_001742507.1 417518 R 439855 CDS YP_001742508.1 170681123 6144780 418813..419007 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 419007 6144780 EcSMS35_0405 Escherichia coli SMS-3-5 hypothetical protein YP_001742508.1 418813 D 439855 CDS YP_001742509.1 170681620 6145306 419027..420247 1 NC_010498.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 420247 smbA 6145306 smbA Escherichia coli SMS-3-5 transport protein YP_001742509.1 419027 D 439855 CDS YP_001742510.1 170682252 6145805 420260..421354 1 NC_010498.1 identified by match to protein family HMM PF07759; putative lipoprotein 421354 6145805 EcSMS35_0407 Escherichia coli SMS-3-5 putative lipoprotein YP_001742510.1 420260 D 439855 CDS YP_001742511.1 170682962 6146451 complement(421412..421720) 1 NC_010498.1 hypothetical protein 421720 6146451 EcSMS35_0408 Escherichia coli SMS-3-5 hypothetical protein YP_001742511.1 421412 R 439855 CDS YP_001742512.1 170683615 6147177 421980..422192 1 NC_010498.1 hypothetical protein 422192 6147177 EcSMS35_0409 Escherichia coli SMS-3-5 hypothetical protein YP_001742512.1 421980 D 439855 CDS YP_001742513.1 170684315 6142905 complement(422216..423310) 1 NC_010498.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 423310 ddl 6142905 ddl Escherichia coli SMS-3-5 D-alanyl-alanine synthetase A YP_001742513.1 422216 R 439855 CDS YP_001742514.1 170679659 6143617 423388..423591 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 423591 6143617 EcSMS35_0411 Escherichia coli SMS-3-5 hypothetical protein YP_001742514.1 423388 D 439855 CDS YP_001742515.1 170680271 6143817 423773..424033 1 NC_010498.1 hypothetical protein 424033 6143817 EcSMS35_0412 Escherichia coli SMS-3-5 hypothetical protein YP_001742515.1 423773 D 439855 CDS YP_001742516.1 170680523 6144438 424133..425548 1 NC_010498.1 identified by match to protein family HMM PF00245; alkaline phosphatase 425548 phoA 6144438 phoA Escherichia coli SMS-3-5 alkaline phosphatase YP_001742516.1 424133 D 439855 CDS YP_001742517.1 170680000 6144693 425667..425987 1 NC_010498.1 identified by match to protein family HMM PF07769; hypothetical protein 425987 psiF 6144693 psiF Escherichia coli SMS-3-5 hypothetical protein YP_001742517.1 425667 D 439855 CDS YP_001742518.1 170683904 6144162 426089..427204 1 NC_010498.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 427204 adrA 6144162 adrA Escherichia coli SMS-3-5 diguanylate cyclase AdrA YP_001742518.1 426089 D 439855 CDS YP_001742519.1 170683285 6143200 complement(427221..428030) 1 NC_010498.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 428030 proC 6143200 proC Escherichia coli SMS-3-5 pyrroline-5-carboxylate reductase YP_001742519.1 427221 R 439855 CDS YP_001742520.1 170682072 6147511 428150..428608 1 NC_010498.1 identified by match to protein family HMM PF02639; hypothetical protein 428608 6147511 EcSMS35_0417 Escherichia coli SMS-3-5 hypothetical protein YP_001742520.1 428150 D 439855 CDS YP_001742521.1 170683799 6146269 428791..429315 1 NC_010498.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 429315 aroL 6146269 aroL Escherichia coli SMS-3-5 shikimate kinase II YP_001742521.1 428791 D 439855 CDS YP_001742522.1 170681907 6143092 429365..429556 1 NC_010498.1 hypothetical protein 429556 6143092 EcSMS35_0419 Escherichia coli SMS-3-5 hypothetical protein YP_001742522.1 429365 D 439855 CDS YP_001742523.1 170681240 6146102 429814..430491 1 NC_010498.1 identified by match to protein family HMM PF07302; hypothetical protein 430491 aroM 6146102 aroM Escherichia coli SMS-3-5 hypothetical protein YP_001742523.1 429814 D 439855 CDS YP_001742524.1 170683956 6145424 430563..430847 1 NC_010498.1 identified by match to protein family HMM PF06865; hypothetical protein 430847 6145424 EcSMS35_0421 Escherichia coli SMS-3-5 hypothetical protein YP_001742524.1 430563 D 439855 CDS YP_001742525.1 170680752 6143253 431055..431333 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 431333 6143253 EcSMS35_0422 Escherichia coli SMS-3-5 hypothetical protein YP_001742525.1 431055 D 439855 CDS YP_001742526.1 170681396 6144927 complement(431491..432402) 1 NC_010498.1 Required for efficient pilin antigenic variation; recombination associated protein 432402 rdgC 6144927 rdgC Escherichia coli SMS-3-5 recombination associated protein YP_001742526.1 431491 R 439855 CDS YP_001742527.1 170682440 6145580 432527..433435 1 NC_010498.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 433435 mak 6145580 mak Escherichia coli SMS-3-5 fructokinase YP_001742527.1 432527 D 439855 CDS YP_001742528.1 170683106 6146639 complement(433575..434843) 1 NC_010498.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 434843 araJ 6146639 araJ Escherichia coli SMS-3-5 MFS transport protein AraJ YP_001742528.1 433575 R 439855 CDS YP_001742529.1 170682477 6147325 complement(434885..438028) 1 NC_010498.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 438028 sbcC 6147325 sbcC Escherichia coli SMS-3-5 exonuclease subunit SbcC YP_001742529.1 434885 R 439855 CDS YP_001742530.1 170683006 6146676 complement(438025..439227) 1 NC_010498.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 439227 sbcD 6146676 sbcD Escherichia coli SMS-3-5 exonuclease subunit SbcD YP_001742530.1 438025 R 439855 CDS YP_001742531.1 170683648 6147222 439213..439344 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 439344 6147222 EcSMS35_0428 Escherichia coli SMS-3-5 hypothetical protein YP_001742531.1 439213 D 439855 CDS YP_001742532.1 170684203 6142940 439417..440106 1 NC_010498.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 440106 phoB 6142940 phoB Escherichia coli SMS-3-5 transcriptional regulator PhoB YP_001742532.1 439417 D 439855 CDS YP_001742533.1 170681341 6143504 440164..441459 1 NC_010498.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 441459 phoR 6143504 phoR Escherichia coli SMS-3-5 phosphate regulon sensor protein YP_001742533.1 440164 D 439855 CDS YP_001742534.1 170680082 6145525 complement(441672..441821) 1 NC_010498.1 hypothetical protein 441821 6145525 EcSMS35_0431 Escherichia coli SMS-3-5 hypothetical protein YP_001742534.1 441672 R 439855 CDS YP_001742535.1 170680091 6144246 441866..443185 1 NC_010498.1 identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 443185 brnQ 6144246 brnQ Escherichia coli SMS-3-5 branched-chain amino acid transport system II carrier protein YP_001742535.1 441866 D 439855 CDS YP_001742536.1 170680647 6144255 443258..444634 1 NC_010498.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 444634 proY 6144255 proY Escherichia coli SMS-3-5 putative proline-specific permease YP_001742536.1 443258 D 439855 CDS YP_001742537.1 170681194 6144822 444790..446607 1 NC_010498.1 identified by match to protein family HMM PF00128; maltodextrin glucosidase 446607 malZ 6144822 malZ Escherichia coli SMS-3-5 maltodextrin glucosidase YP_001742537.1 444790 D 439855 CDS YP_001742538.1 170681654 6145378 446794..448239 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 448239 6145378 EcSMS35_0435 Escherichia coli SMS-3-5 hypothetical protein YP_001742538.1 446794 D 439855 CDS YP_001742539.1 170684080 6145840 complement(448260..448841) 1 NC_010498.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase 448841 acpH 6145840 acpH Escherichia coli SMS-3-5 acyl carrier protein phosphodiesterase YP_001742539.1 448260 R 439855 CDS YP_001742540.1 170682221 6143380 448934..450004 1 NC_010498.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 450004 queA 6143380 queA Escherichia coli SMS-3-5 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_001742540.1 448934 D 439855 CDS YP_001742541.1 170680278 6146420 450059..451186 1 NC_010498.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 451186 tgt 6146420 tgt Escherichia coli SMS-3-5 queuine tRNA-ribosyltransferase YP_001742541.1 450059 D 439855 CDS YP_001742542.1 170683289 6144445 451209..451541 1 NC_010498.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 451541 yajC 6144445 yajC Escherichia coli SMS-3-5 preprotein translocase subunit YajC YP_001742542.1 451209 D 439855 CDS YP_001742543.1 170680742 6147515 451569..453416 1 NC_010498.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 453416 secD 6147515 secD Escherichia coli SMS-3-5 preprotein translocase subunit SecD YP_001742543.1 451569 D 439855 CDS YP_001742544.1 170684249 6144917 453427..454398 1 NC_010498.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 454398 secF 6144917 secF Escherichia coli SMS-3-5 preprotein translocase subunit SecF YP_001742544.1 453427 D 439855 CDS YP_001742545.1 170679872 6143551 454549..454791 1 NC_010498.1 identified by match to protein family HMM PF03693; match to protein family HMM TIGR02606; CC2985 family addiction module antidote protein 454791 6143551 EcSMS35_0442 Escherichia coli SMS-3-5 CC2985 family addiction module antidote protein YP_001742545.1 454549 D 439855 CDS YP_001742546.1 170682953 6144034 454784..455065 1 NC_010498.1 identified by match to protein family HMM PF05016; RelE/ParE family plasmid stabilization system protein 455065 6144034 EcSMS35_0443 Escherichia coli SMS-3-5 RelE/ParE family plasmid stabilization system protein YP_001742546.1 454784 D 439855 CDS YP_001742547.1 170683294 6147168 455153..455500 1 NC_010498.1 identified by match to protein family HMM PF01844; hypothetical protein 455500 6147168 EcSMS35_0444 Escherichia coli SMS-3-5 hypothetical protein YP_001742547.1 455153 D 439855 CDS YP_001742548.1 170680575 6147520 complement(455538..456422) 1 NC_010498.1 identified by match to protein family HMM PF03502; nucleoside-specific channel-forming protein Tsx 456422 tsx1 6147520 tsx1 Escherichia coli SMS-3-5 nucleoside-specific channel-forming protein Tsx YP_001742548.1 455538 R 439855 CDS YP_001742549.1 170682659 6142930 457626..458834 1 NC_010498.1 identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766; IS605 family transposase orfB 458834 6142930 EcSMS35_0448 Escherichia coli SMS-3-5 IS605 family transposase orfB YP_001742549.1 457626 D 439855 CDS YP_001742550.1 170680845 6143940 459158..459607 1 NC_010498.1 identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR 459607 nrdR 6143940 nrdR Escherichia coli SMS-3-5 transcriptional regulator NrdR YP_001742550.1 459158 D 439855 CDS YP_001742551.1 170680144 6145022 459611..460714 1 NC_010498.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 460714 ribD 6145022 ribD Escherichia coli SMS-3-5 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_001742551.1 459611 D 439855 CDS YP_001742552.1 170680589 6144310 460803..461273 1 NC_010498.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 461273 ribH 6144310 ribH Escherichia coli SMS-3-5 6,7-dimethyl-8-ribityllumazine synthase YP_001742552.1 460803 D 439855 CDS YP_001742553.1 170681155 6144760 461293..461712 1 NC_010498.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 461712 nusB 6144760 nusB Escherichia coli SMS-3-5 transcription antitermination protein NusB YP_001742553.1 461293 D 439855 CDS YP_001742554.1 170681628 6145338 461790..462767 1 NC_010498.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 462767 thiL 6145338 thiL Escherichia coli SMS-3-5 thiamine monophosphate kinase YP_001742554.1 461790 D 439855 CDS YP_001742555.1 170682164 6145813 462754..463263 1 NC_010498.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 463263 pgpA 6145813 pgpA Escherichia coli SMS-3-5 phosphatidylglycerophosphatase A YP_001742555.1 462754 D 439855 CDS YP_001742556.1 170682731 6146363 complement(463317..464291) 1 NC_010498.1 identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 464291 6146363 EcSMS35_0455 Escherichia coli SMS-3-5 aldo/keto reductase family oxidoreductase YP_001742556.1 463317 R 439855 CDS YP_001742557.1 170680644 6146939 complement(464346..466208) 1 NC_010498.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 466208 dxs 6146939 dxs Escherichia coli SMS-3-5 1-deoxy-D-xylulose-5-phosphate synthase YP_001742557.1 464346 R 439855 CDS YP_001742558.1 170683582 6144819 complement(466233..467132) 1 NC_010498.1 identified by match to protein family HMM PF00348; geranyltranstransferase 467132 ispA 6144819 ispA Escherichia coli SMS-3-5 geranyltranstransferase YP_001742558.1 466233 R 439855 CDS YP_001742559.1 170681913 6142873 complement(467132..467374) 1 NC_010498.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 467374 xseB 6142873 xseB Escherichia coli SMS-3-5 exodeoxyribonuclease VII small subunit YP_001742559.1 467132 R 439855 CDS YP_001742560.1 170679960 6146108 467580..469028 1 NC_010498.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 469028 thiI 6146108 thiI Escherichia coli SMS-3-5 thiamine biosynthesis protein ThiI YP_001742560.1 467580 D 439855 CDS YP_001742561.1 170681670 6144122 complement(469082..469672) 1 NC_010498.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; DJ-1 family protein 469672 thiJ 6144122 thiJ Escherichia coli SMS-3-5 DJ-1 family protein YP_001742561.1 469082 R 439855 CDS YP_001742562.1 170681172 6145856 complement(469635..470546) 1 NC_010498.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 470546 panE 6145856 panE Escherichia coli SMS-3-5 2-dehydropantoate 2-reductase YP_001742562.1 469635 R 439855 CDS YP_001742563.1 170680710 6145356 470714..471205 1 NC_010498.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 471205 6145356 EcSMS35_0462 Escherichia coli SMS-3-5 putative nucleotide-binding protein YP_001742563.1 470714 D 439855 CDS YP_001742564.1 170679618 6144885 complement(471333..472697) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 472697 6144885 EcSMS35_0463 Escherichia coli SMS-3-5 major facilitator transporter YP_001742564.1 471333 R 439855 CDS YP_001742565.1 170681703 6143775 472840..472995 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 472995 6143775 EcSMS35_0464 Escherichia coli SMS-3-5 hypothetical protein YP_001742565.1 472840 D 439855 CDS YP_001742566.1 170681040 6145889 473104..474039 1 NC_010498.1 identified by match to protein family HMM PF08238; hypothetical protein 474039 6145889 EcSMS35_0465 Escherichia coli SMS-3-5 hypothetical protein YP_001742566.1 473104 D 439855 CDS YP_001742567.1 170680596 6145221 complement(474095..474637) 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 474637 6145221 EcSMS35_0466 Escherichia coli SMS-3-5 acetyltransferase YP_001742567.1 474095 R 439855 CDS YP_001742568.1 170680065 6144768 complement(474621..474932) 1 NC_010498.1 identified by match to protein family HMM PF08681; hypothetical protein 474932 6144768 EcSMS35_0467 Escherichia coli SMS-3-5 hypothetical protein YP_001742568.1 474621 R 439855 CDS YP_001742569.1 170682454 6144229 complement(475117..476007) 1 NC_010498.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 476007 cyoE 6144229 cyoE Escherichia coli SMS-3-5 protoheme IX farnesyltransferase YP_001742569.1 475117 R 439855 CDS YP_001742570.1 170683697 6146653 complement(476019..476348) 1 NC_010498.1 identified by match to protein family HMM PF03626; match to protein family HMM TIGR02847; cytochrome o ubiquinol oxidase subunit IV 476348 cyoD 6146653 cyoD Escherichia coli SMS-3-5 cytochrome o ubiquinol oxidase subunit IV YP_001742570.1 476019 R 439855 CDS YP_001742571.1 170680623 6142989 complement(476348..476962) 1 NC_010498.1 identified by match to protein family HMM PF00510; match to protein family HMM TIGR02842; cytochrome o ubiquinol oxidase subunit III 476962 cyoC 6142989 cyoC Escherichia coli SMS-3-5 cytochrome o ubiquinol oxidase subunit III YP_001742571.1 476348 R 439855 CDS YP_001742572.1 170683544 6144798 complement(476952..478943) 1 NC_010498.1 identified by match to protein family HMM PF00115; match to protein family HMM TIGR02843; cytochrome o ubiquinol oxidase, subunit I 478943 cyoB 6144798 cyoB Escherichia coli SMS-3-5 cytochrome o ubiquinol oxidase, subunit I YP_001742572.1 476952 R 439855 CDS YP_001742573.1 170683800 6142834 complement(478965..479912) 1 NC_010498.1 identified by match to protein family HMM PF00116; match to protein family HMM PF06481; match to protein family HMM TIGR01433; cytochrome o ubiquinol oxidase subunit II 479912 cyoA 6142834 cyoA Escherichia coli SMS-3-5 cytochrome o ubiquinol oxidase subunit II YP_001742573.1 478965 R 439855 CDS YP_001742574.1 170681938 6143093 480214..480357 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 480357 6143093 EcSMS35_0473 Escherichia coli SMS-3-5 hypothetical protein YP_001742574.1 480214 D 439855 CDS YP_001742575.1 170682808 6146134 complement(480372..481847) 1 NC_010498.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 481847 ampG 6146134 ampG Escherichia coli SMS-3-5 muropeptide transporter YP_001742575.1 480372 R 439855 CDS YP_001742576.1 170681187 6147019 complement(481891..482469) 1 NC_010498.1 identified by match to protein family HMM PF03923; hypothetical protein 482469 6147019 EcSMS35_0475 Escherichia coli SMS-3-5 hypothetical protein YP_001742576.1 481891 R 439855 CDS YP_001742577.1 170680924 6145371 complement(482519..482650) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 482650 6145371 EcSMS35_0476 Escherichia coli SMS-3-5 hypothetical protein YP_001742577.1 482519 R 439855 CDS YP_001742578.1 170681580 6145105 482774..483091 1 NC_010498.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 483091 6145105 EcSMS35_0477 Escherichia coli SMS-3-5 transcriptional regulator BolA YP_001742578.1 482774 D 439855 CDS YP_001742579.1 170682286 6145765 483142..483288 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 483288 6145765 EcSMS35_0478 Escherichia coli SMS-3-5 hypothetical protein YP_001742579.1 483142 D 439855 CDS YP_001742580.1 170682129 6146485 483435..484733 1 NC_010498.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 484733 tig 6146485 tig Escherichia coli SMS-3-5 trigger factor YP_001742580.1 483435 D 439855 CDS YP_001742581.1 170683276 6146328 484979..485602 1 NC_010498.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 485602 clpP 6146328 clpP Escherichia coli SMS-3-5 ATP-dependent Clp protease proteolytic subunit YP_001742581.1 484979 D 439855 CDS YP_001742582.1 170682782 6147502 485728..487002 1 NC_010498.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 487002 clpX 6147502 clpX Escherichia coli SMS-3-5 ATP-dependent protease ATP-binding subunit ClpX YP_001742582.1 485728 D 439855 CDS YP_001742583.1 170682239 6146991 487190..489544 1 NC_010498.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02190; match to protein family HMM PF05362; match to protein family HMM PF07728; match to protein family HMM TIGR00763; DNA-binding ATP-dependent protease La 489544 lon 6146991 lon Escherichia coli SMS-3-5 DNA-binding ATP-dependent protease La YP_001742583.1 487190 D 439855 CDS YP_001742584.1 170681712 6146438 489753..490025 1 NC_010498.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 490025 hupB 6146438 hupB Escherichia coli SMS-3-5 transcriptional regulator HU subunit beta YP_001742584.1 489753 D 439855 CDS YP_001742585.1 170681699 6145900 490217..492088 1 NC_010498.1 identified by match to protein family HMM PF00639; match to protein family HMM PF09312; peptidyl-prolyl cis-trans isomerase (rotamase D) 492088 ppiD 6145900 ppiD Escherichia coli SMS-3-5 peptidyl-prolyl cis-trans isomerase (rotamase D) YP_001742585.1 490217 D 439855 CDS YP_001742586.1 170681053 6145885 492239..492610 1 NC_010498.1 identified by match to protein family HMM TIGR00426; competence protein ComEA 492610 6145885 EcSMS35_0485 Escherichia coli SMS-3-5 competence protein ComEA YP_001742586.1 492239 D 439855 CDS YP_001742587.1 170679664 6145234 492716..493114 1 NC_010498.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00051; thioesterase family protein 493114 6145234 EcSMS35_0486 Escherichia coli SMS-3-5 thioesterase family protein YP_001742587.1 492716 D 439855 CDS YP_001742588.1 170680140 6143822 complement(493166..493861) 1 NC_010498.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 493861 queC 6143822 queC Escherichia coli SMS-3-5 queuosine biosynthesis protein QueC YP_001742588.1 493166 R 439855 CDS YP_001742589.1 170683749 6144306 complement(493926..495626) 1 NC_010498.1 identified by match to protein family HMM PF00496; solute-binding family 5 protein 495626 6144306 EcSMS35_0488 Escherichia coli SMS-3-5 solute-binding family 5 protein YP_001742589.1 493926 R 439855 CDS YP_001742590.1 170683210 6143041 495726..496544 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hydrolase Cof 496544 cof 6143041 cof Escherichia coli SMS-3-5 hydrolase Cof YP_001742590.1 495726 D 439855 CDS YP_001742591.1 170683247 6147431 496697..497155 1 NC_010498.1 identified by match to protein family HMM PF01037; AsnC family transcriptional regulator 497155 6147431 EcSMS35_0490 Escherichia coli SMS-3-5 AsnC family transcriptional regulator YP_001742591.1 496697 D 439855 CDS YP_001742592.1 170682724 6147470 497185..498957 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; putative multidrug transporter membrane\ATP-binding components 498957 mdlA 6147470 mdlA Escherichia coli SMS-3-5 putative multidrug transporter membrane\ATP-binding components YP_001742592.1 497185 D 439855 CDS YP_001742593.1 170679907 6146932 498950..500731 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; putative multidrug transporter membrane\ATP-binding components 500731 mdlB 6146932 mdlB Escherichia coli SMS-3-5 putative multidrug transporter membrane\ATP-binding components YP_001742593.1 498950 D 439855 CDS YP_001742594.1 170684075 6144069 complement(500745..500885) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 500885 6144069 EcSMS35_0493 Escherichia coli SMS-3-5 hypothetical protein YP_001742594.1 500745 R 439855 CDS YP_001742595.1 170681150 6143375 500912..501250 1 NC_010498.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 501250 glnK 6143375 glnK Escherichia coli SMS-3-5 nitrogen regulatory protein P-II 2 YP_001742595.1 500912 D 439855 CDS YP_001742596.1 170680701 6145333 501280..502566 1 NC_010498.1 identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836; ammonium transporter 502566 amt 6145333 amt Escherichia coli SMS-3-5 ammonium transporter YP_001742596.1 501280 D 439855 CDS YP_001742597.1 170682584 6144876 complement(502615..503475) 1 NC_010498.1 identified by match to protein family HMM PF02551; match to protein family HMM TIGR00189; acyl-CoA thioesterase II 503475 tesB 6144876 tesB Escherichia coli SMS-3-5 acyl-CoA thioesterase II YP_001742597.1 502615 R 439855 CDS YP_001742598.1 170681958 6146789 503693..504265 1 NC_010498.1 putative lipoprotein 504265 6146789 EcSMS35_0497 Escherichia coli SMS-3-5 putative lipoprotein YP_001742598.1 503693 D 439855 CDS YP_001742599.1 170682578 6146154 complement(504296..504607) 1 NC_010498.1 identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; methylated-DNA-[protein]-cysteine S-methyltransferase 504607 6146154 EcSMS35_0498 Escherichia coli SMS-3-5 methylated-DNA-[protein]-cysteine S-methyltransferase YP_001742599.1 504296 R 439855 CDS YP_001742600.1 170682038 6146783 504986..505339 1 NC_010498.1 identified by match to protein family HMM PF07237; hypothetical protein 505339 6146783 EcSMS35_0499 Escherichia coli SMS-3-5 hypothetical protein YP_001742600.1 504986 D 439855 CDS YP_001742601.1 170682326 6146235 complement(505380..506930) 1 NC_010498.1 identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 506930 6146235 EcSMS35_0500 Escherichia coli SMS-3-5 cyclic diguanylate phosphodiesterase domain-containing protein YP_001742601.1 505380 R 439855 CDS YP_001742602.1 170684122 6146525 complement(507094..507564) 1 NC_010498.1 hypothetical protein 507564 6146525 EcSMS35_0501 Escherichia coli SMS-3-5 hypothetical protein YP_001742602.1 507094 R 439855 CDS YP_001742603.1 170683461 6143422 complement(507680..508231) 1 NC_010498.1 identified by match to protein family HMM PF00132; maltose O-acetyltransferase 508231 maa 6143422 maa Escherichia coli SMS-3-5 maltose O-acetyltransferase YP_001742603.1 507680 R 439855 CDS YP_001742604.1 170683314 6142749 complement(508403..508621) 1 NC_010498.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 508621 6142749 EcSMS35_0503 Escherichia coli SMS-3-5 hemolysin expression-modulating protein YP_001742604.1 508403 R 439855 CDS YP_001742605.1 170680298 6142599 complement(508647..509021) 1 NC_010498.1 hypothetical protein 509021 6142599 EcSMS35_0504 Escherichia coli SMS-3-5 hypothetical protein YP_001742605.1 508647 R 439855 CDS YP_001742606.1 170680127 6144466 complement(509567..512716) 1 NC_010498.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; acriflavine resistance protein B 512716 6144466 EcSMS35_0505 Escherichia coli SMS-3-5 acriflavine resistance protein B YP_001742606.1 509567 R 439855 CDS YP_001742607.1 170681835 6144292 complement(512739..513968) 1 NC_010498.1 identified by similarity to SP:P0AE06; match to protein family HMM PF00529; match to protein family HMM TIGR01730; acriflavine resistance protein A 513968 acrA 6144292 acrA Escherichia coli SMS-3-5 acriflavine resistance protein A YP_001742607.1 512739 R 439855 CDS YP_001742608.1 170681180 6146028 514074..514721 1 NC_010498.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 514721 acrR 6146028 acrR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor AcrR YP_001742608.1 514074 D 439855 CDS YP_001742609.1 170682849 6145364 514849..518211 1 NC_010498.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 518211 kefA 6145364 kefA Escherichia coli SMS-3-5 potassium efflux protein KefA YP_001742609.1 514849 D 439855 CDS YP_001742610.1 170682816 6147062 complement(518423..518584) 1 NC_010498.1 hypothetical protein 518584 6147062 EcSMS35_0509 Escherichia coli SMS-3-5 hypothetical protein YP_001742610.1 518423 R 439855 CDS YP_001742611.1 170680349 6147027 complement(518598..519125) 1 NC_010498.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 519125 priC 6147027 priC Escherichia coli SMS-3-5 primosomal replication protein N'' YP_001742611.1 518598 R 439855 CDS YP_001742612.1 170684286 6144517 519195..519572 1 NC_010498.1 identified by match to protein family HMM PF04304; hypothetical protein 519572 6144517 EcSMS35_0511 Escherichia coli SMS-3-5 hypothetical protein YP_001742612.1 519195 D 439855 CDS YP_001742613.1 170683752 6143588 519725..520276 1 NC_010498.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 520276 apt 6143588 apt Escherichia coli SMS-3-5 adenine phosphoribosyltransferase YP_001742613.1 519725 D 439855 CDS YP_001742614.1 170681602 6143044 520405..522336 1 NC_010498.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 522336 dnaX 6143044 dnaX Escherichia coli SMS-3-5 DNA polymerase III subunits gamma and tau YP_001742614.1 520405 D 439855 CDS YP_001742615.1 170682138 6145787 522389..522718 1 NC_010498.1 ybaB; identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 522718 6145787 EcSMS35_0514 Escherichia coli SMS-3-5 hypothetical protein YP_001742615.1 522389 D 439855 CDS YP_001742616.1 170682989 6146337 522718..523323 1 NC_010498.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 523323 recR 6146337 recR Escherichia coli SMS-3-5 recombination protein RecR YP_001742616.1 522718 D 439855 CDS YP_001742617.1 170683488 6147205 523433..525307 1 NC_010498.1 molecular chaperone; heat shock protein 90 525307 htpG 6147205 htpG Escherichia coli SMS-3-5 heat shock protein 90 YP_001742617.1 523433 D 439855 CDS YP_001742618.1 170680190 6142777 complement(525373..525498) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 525498 6142777 EcSMS35_0517 Escherichia coli SMS-3-5 hypothetical protein YP_001742618.1 525373 R 439855 CDS YP_001742619.1 170679682 6144356 525488..526132 1 NC_010498.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 526132 adk 6144356 adk Escherichia coli SMS-3-5 adenylate kinase YP_001742619.1 525488 D 439855 CDS YP_001742620.1 170680326 6143840 526264..527226 1 NC_010498.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 527226 hemH 6143840 hemH Escherichia coli SMS-3-5 ferrochelatase YP_001742620.1 526264 D 439855 CDS YP_001742621.1 170680303 6144494 complement(527223..528182) 1 NC_010498.1 identified by match to protein family HMM PF07859; acetyl esterase 528182 aes 6144494 aes Escherichia coli SMS-3-5 acetyl esterase YP_001742621.1 527223 R 439855 CDS YP_001742622.1 170680689 6144471 528334..529638 1 NC_010498.1 identified by match to protein family HMM PF00294; inosine kinase 529638 gsk 6144471 gsk Escherichia coli SMS-3-5 inosine kinase YP_001742622.1 528334 D 439855 CDS YP_001742623.1 170681342 6144864 complement(529768..531444) 1 NC_010498.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein 531444 6144864 EcSMS35_0522 Escherichia coli SMS-3-5 putative cation:proton antiport protein YP_001742623.1 529768 R 439855 CDS YP_001742624.1 170682753 6145526 complement(531682..532902) 1 NC_010498.1 identified by match to protein family HMM PF07690; fosmidomycin resistance protein 532902 fsr 6145526 fsr Escherichia coli SMS-3-5 fosmidomycin resistance protein YP_001742624.1 531682 R 439855 CDS YP_001742625.1 170682853 6146962 533120..534772 1 NC_010498.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 534772 ushA 6146962 ushA Escherichia coli SMS-3-5 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor YP_001742625.1 533120 D 439855 CDS YP_001742626.1 170683758 6147066 complement(534809..535288) 1 NC_010498.1 identified by match to protein family HMM PF04073; match to protein family HMM TIGR00011; hypothetical protein 535288 6147066 EcSMS35_0525 Escherichia coli SMS-3-5 hypothetical protein YP_001742626.1 534809 R 439855 CDS YP_001742627.1 170683262 6143050 complement(535492..536286) 1 NC_010498.1 identified by match to protein family HMM PF07446; GumN family protein 536286 6143050 EcSMS35_0526 Escherichia coli SMS-3-5 GumN family protein YP_001742627.1 535492 R 439855 CDS YP_001742628.1 170680233 6147486 complement(536590..539094) 1 NC_010498.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper exporting ATPase 539094 copA 6147486 copA Escherichia coli SMS-3-5 copper exporting ATPase YP_001742628.1 536590 R 439855 CDS YP_001742629.1 170679576 6144400 539357..540289 1 NC_010498.1 catalyzes the formation of glutamate from glutamine; glutaminase 540289 glsA1 6144400 glsA1 Escherichia coli SMS-3-5 glutaminase YP_001742629.1 539357 D 439855 CDS YP_001742630.1 170681675 6143733 540292..541584 1 NC_010498.1 identified by match to protein family HMM PF00324; match to protein family HMM PF01490; match to protein family HMM PF03845; amino acid permease family protein 541584 6143733 EcSMS35_0529 Escherichia coli SMS-3-5 amino acid permease family protein YP_001742630.1 540292 D 439855 CDS YP_001742631.1 170680958 6145861 541709..542116 1 NC_010498.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 542116 cueR 6145861 cueR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator CueR YP_001742631.1 541709 D 439855 CDS YP_001742632.1 170680294 6145139 complement(542120..542287) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 542287 6145139 EcSMS35_0531 Escherichia coli SMS-3-5 hypothetical protein YP_001742632.1 542120 R 439855 CDS YP_001742633.1 170680588 6144462 complement(542320..542742) 1 NC_010498.1 identified by similarity to GB:CAL11950.1; putative lipoprotein 542742 6144462 EcSMS35_0532 Escherichia coli SMS-3-5 putative lipoprotein YP_001742633.1 542320 R 439855 CDS YP_001742634.1 170684227 6144759 complement(542796..543812) 1 NC_010498.1 identified by match to protein family HMM PF03895; hypothetical protein 543812 6144759 EcSMS35_0533 Escherichia coli SMS-3-5 hypothetical protein YP_001742634.1 542796 R 439855 CDS YP_001742635.1 170682499 6143528 complement(543910..544032) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 544032 6143528 EcSMS35_0534 Escherichia coli SMS-3-5 hypothetical protein YP_001742635.1 543910 R 439855 CDS YP_001742636.1 170682884 6146699 544057..544185 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 544185 6146699 EcSMS35_0535 Escherichia coli SMS-3-5 hypothetical protein YP_001742636.1 544057 D 439855 CDS YP_001742637.1 170680942 6147097 544178..544540 1 NC_010498.1 identified by similarity to GB:ABB60623.1; hypothetical protein 544540 6147097 EcSMS35_0536 Escherichia coli SMS-3-5 hypothetical protein YP_001742637.1 544178 D 439855 CDS YP_001742638.1 170680890 6145123 complement(544643..545101) 1 NC_010498.1 identified by match to protein family HMM PF01957; nodulation efficiency family protein 545101 6145123 EcSMS35_0537 Escherichia coli SMS-3-5 nodulation efficiency family protein YP_001742638.1 544643 R 439855 CDS YP_001742639.1 170681599 6145068 complement(545098..546015) 1 NC_010498.1 identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein 546015 6145068 EcSMS35_0538 Escherichia coli SMS-3-5 SPFH domain-containing protein/band 7 family protein YP_001742639.1 545098 R 439855 CDS YP_001742640.1 170679660 6145784 546161..546838 1 NC_010498.1 identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein YbbL 546838 6145784 EcSMS35_0539 Escherichia coli SMS-3-5 putative ABC transporter ATP-binding protein YbbL YP_001742640.1 546161 D 439855 CDS YP_001742641.1 170682778 6143818 546825..547604 1 NC_010498.1 identified by match to protein family HMM PF03649; match to protein family HMM TIGR00245; hypothetical protein 547604 6143818 EcSMS35_0540 Escherichia coli SMS-3-5 hypothetical protein YP_001742641.1 546825 D 439855 CDS YP_001742642.1 170681623 6146987 complement(547784..548638) 1 NC_010498.1 identified by match to protein family HMM PF00085; protein YbbN 548638 ybbN 6146987 ybbN Escherichia coli SMS-3-5 protein YbbN YP_001742642.1 547784 R 439855 CDS YP_001742643.1 170681540 6145808 complement(548699..549469) 1 NC_010498.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase 549469 6145808 EcSMS35_0542 Escherichia coli SMS-3-5 short chain dehydrogenase YP_001742643.1 548699 R 439855 CDS YP_001742644.1 170679602 6145725 complement(549498..550121) 1 NC_010498.1 identified by match to protein family HMM PF00657; multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 550121 tesA 6145725 tesA Escherichia coli SMS-3-5 multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 YP_001742644.1 549498 R 439855 CDS YP_001742645.1 170683791 6143759 550092..550778 1 NC_010498.1 identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein YbbA 550778 6143759 EcSMS35_0544 Escherichia coli SMS-3-5 putative ABC transporter ATP-binding protein YbbA YP_001742645.1 550092 D 439855 CDS YP_001742646.1 170683536 6143083 550775..553189 1 NC_010498.1 identified by match to protein family HMM PF02687; efflux ABC transporter permease 553189 6143083 EcSMS35_0545 Escherichia coli SMS-3-5 efflux ABC transporter permease YP_001742646.1 550775 D 439855 CDS YP_001742647.1 170683025 6142826 complement(553320..554414) 1 NC_010498.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 554414 selU 6142826 selU Escherichia coli SMS-3-5 tRNA 2-selenouridine synthase YP_001742647.1 553320 R 439855 CDS YP_001742648.1 170682910 6147241 complement(554483..555409) 1 NC_010498.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 555409 6147241 EcSMS35_0547 Escherichia coli SMS-3-5 DNA-binding transcriptional activator AllS YP_001742648.1 554483 R 439855 CDS YP_001742649.1 170682305 6147124 555639..556121 1 NC_010498.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 556121 allA 6147124 allA Escherichia coli SMS-3-5 ureidoglycolate hydrolase YP_001742649.1 555639 D 439855 CDS YP_001742650.1 170680846 6146504 556244..557014 1 NC_010498.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 557014 allR 6146504 allR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor AllR YP_001742650.1 556244 D 439855 CDS YP_001742651.1 170682793 6145023 557104..558885 1 NC_010498.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 558885 gcl 6145023 gcl Escherichia coli SMS-3-5 glyoxylate carboligase YP_001742651.1 557104 D 439855 CDS YP_001742652.1 170683109 6147002 558898..559674 1 NC_010498.1 identified by match to protein family HMM PF01261; match to protein family HMM TIGR03234; hydroxypyruvate isomerase 559674 hyi 6147002 hyi Escherichia coli SMS-3-5 hydroxypyruvate isomerase YP_001742652.1 558898 D 439855 CDS YP_001742653.1 170682413 6147328 559774..560652 1 NC_010498.1 identified by match to protein family HMM PF03446; match to protein family HMM TIGR01505; 2-hydroxy-3-oxopropionate reductase 560652 6147328 EcSMS35_0552 Escherichia coli SMS-3-5 2-hydroxy-3-oxopropionate reductase YP_001742653.1 559774 D 439855 CDS YP_001742654.1 170680776 6146612 560822..562276 1 NC_010498.1 identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800; allantoin permease 562276 6146612 EcSMS35_0553 Escherichia coli SMS-3-5 allantoin permease YP_001742654.1 560822 D 439855 CDS YP_001742655.1 170682646 6144951 562337..563698 1 NC_010498.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 563698 allB 6144951 allB Escherichia coli SMS-3-5 allantoinase YP_001742655.1 562337 D 439855 CDS YP_001742656.1 170683408 6145984 564855..565067 1 NC_010498.1 identified by similarity to GB:ABD51571.1; IS1 transposase orfA 565067 6145984 EcSMS35_0556 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001742656.1 564855 D 439855 CDS YP_001742657.1 170681291 6142694 565078..565581 1 NC_010498.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 565581 6142694 EcSMS35_0557 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001742657.1 565078 D 439855 CDS YP_001742658.1 170680619 6142744 565854..566999 1 NC_010498.1 identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase II 566999 6142744 EcSMS35_0559 Escherichia coli SMS-3-5 glycerate kinase II YP_001742658.1 565854 D 439855 CDS YP_001742659.1 170682104 6144793 complement(567129..567914) 1 NC_010498.1 identified by match to protein family HMM PF05899; match to protein family HMM PF07883; match to protein family HMM TIGR03214; hypothetical protein 567914 6144793 EcSMS35_0560 Escherichia coli SMS-3-5 hypothetical protein YP_001742659.1 567129 R 439855 CDS YP_001742660.1 170681093 6146302 complement(567925..569160) 1 NC_010498.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 569160 allC 6146302 allC Escherichia coli SMS-3-5 allantoate amidohydrolase YP_001742660.1 567925 R 439855 CDS YP_001742661.1 170683300 6145275 complement(569182..570231) 1 NC_010498.1 identified by match to protein family HMM PF02615; match to protein family HMM TIGR03175; ureidoglycolate dehydrogenase 570231 allD 6145275 allD Escherichia coli SMS-3-5 ureidoglycolate dehydrogenase YP_001742661.1 569182 R 439855 CDS YP_001742662.1 170682785 6147526 570548..572215 1 NC_010498.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 572215 6147526 EcSMS35_0563 Escherichia coli SMS-3-5 membrane protein FdrA YP_001742662.1 570548 D 439855 CDS YP_001742663.1 170680657 6146994 572225..573484 1 NC_010498.1 identified by match to protein family HMM PF06545; hypothetical protein 573484 6146994 EcSMS35_0564 Escherichia coli SMS-3-5 hypothetical protein YP_001742663.1 572225 D 439855 CDS YP_001742664.1 170680073 6144832 573495..574310 1 NC_010498.1 hypothetical protein 574310 6144832 EcSMS35_0565 Escherichia coli SMS-3-5 hypothetical protein YP_001742664.1 573495 D 439855 CDS YP_001742665.1 170681647 6144237 574307..575200 1 NC_010498.1 identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746; carbamate kinase 575200 arcC 6144237 arcC Escherichia coli SMS-3-5 carbamate kinase YP_001742665.1 574307 D 439855 CDS YP_001742666.1 170681139 6145833 complement(575433..576500) 1 NC_010498.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 576500 purK 6145833 purK Escherichia coli SMS-3-5 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001742666.1 575433 R 439855 CDS YP_001742667.1 170682307 6145322 complement(576497..577006) 1 NC_010498.1 identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit 577006 purE 6145322 purE Escherichia coli SMS-3-5 phosphoribosylaminoimidazole carboxylase, catalytic subunit YP_001742667.1 576497 R 439855 CDS YP_001742668.1 170682091 6146506 complement(577123..577845) 1 NC_010498.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 577845 lpxH 6146506 lpxH Escherichia coli SMS-3-5 UDP-2,3-diacylglucosamine hydrolase YP_001742668.1 577123 R 439855 CDS YP_001742669.1 170683759 6146288 complement(577848..578342) 1 NC_010498.1 identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase B (rotamase B) 578342 ppiB 6146288 ppiB Escherichia coli SMS-3-5 peptidyl-prolyl cis-trans isomerase B (rotamase B) YP_001742669.1 577848 R 439855 CDS YP_001742670.1 170683319 6143051 578516..579901 1 NC_010498.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 579901 cysS 6143051 cysS Escherichia coli SMS-3-5 cysteinyl-tRNA synthetase YP_001742670.1 578516 D 439855 CDS YP_001742671.1 170679859 6142604 complement(579937..580458) 1 NC_010498.1 identified by match to protein family HMM PF04307; hypothetical protein 580458 6142604 EcSMS35_0572 Escherichia coli SMS-3-5 hypothetical protein YP_001742671.1 579937 R 439855 CDS YP_001742672.1 170680369 6144021 complement(580566..580778) 1 NC_010498.1 hypothetical protein 580778 6144021 EcSMS35_0573 Escherichia coli SMS-3-5 hypothetical protein YP_001742672.1 580566 R 439855 CDS YP_001742673.1 170682209 6144537 complement(580780..581646) 1 NC_010498.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 581646 folD 6144537 folD Escherichia coli SMS-3-5 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001742673.1 580780 R 439855 CDS YP_001742674.1 170682722 6146408 582118..582660 1 NC_010498.1 identified by match to protein family HMM PF00419; type-1 fimbrial protein 582660 6146408 EcSMS35_0575 Escherichia coli SMS-3-5 type-1 fimbrial protein YP_001742674.1 582118 D 439855 CDS YP_001742675.1 170683244 6146930 582879..583571 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein FimC-like protein 583571 6146930 EcSMS35_0576 Escherichia coli SMS-3-5 chaperone protein FimC-like protein YP_001742675.1 582879 D 439855 CDS YP_001742676.1 170682983 6147467 583602..586211 1 NC_010498.1 identified by similarity to SP:P77468; match to protein family HMM PF00577; outer membrane usher protein SfmD 586211 sfmD 6147467 sfmD Escherichia coli SMS-3-5 outer membrane usher protein SfmD YP_001742676.1 583602 D 439855 CDS YP_001742677.1 170683627 6147199 586224..587231 1 NC_010498.1 mannose binding protein FimH-like protein 587231 6147199 EcSMS35_0578 Escherichia coli SMS-3-5 mannose binding protein FimH-like protein YP_001742677.1 586224 D 439855 CDS YP_001742678.1 170684282 6142918 587560..587757 1 NC_010498.1 fimbrial protein 587757 6142918 EcSMS35_0579 Escherichia coli SMS-3-5 fimbrial protein YP_001742678.1 587560 D 439855 CDS YP_001742679.1 170681356 6143584 complement(587760..588392) 1 NC_010498.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 588392 fimZ 6143584 fimZ Escherichia coli SMS-3-5 transcriptional regulator FimZ YP_001742679.1 587760 R 439855 CDS YP_001742680.1 170683746 6145540 588446..588601 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 588601 6145540 EcSMS35_0581 Escherichia coli SMS-3-5 hypothetical protein YP_001742680.1 588446 D 439855 CDS YP_001742681.1 170679632 6143669 complement(588756..589517) 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 589517 6143669 EcSMS35_0583 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001742681.1 588756 R 439855 CDS YP_001742682.1 170680297 6143789 complement(589700..590590) 1 NC_010498.1 hypothetical protein 590590 6143789 EcSMS35_0584 Escherichia coli SMS-3-5 hypothetical protein YP_001742682.1 589700 R 439855 CDS YP_001742683.1 170679633 6144465 complement(590591..593563) 1 NC_010498.1 identified by match to protein family HMM PF00515; match to protein family HMM PF07719; bacteriophage N4 receptor, outer membrane subunit 593563 6144465 EcSMS35_0585 Escherichia coli SMS-3-5 bacteriophage N4 receptor, outer membrane subunit YP_001742683.1 590591 R 439855 CDS YP_001742684.1 170680338 6143790 complement(593550..595787) 1 NC_010498.1 identified by similarity to SP:P0AFA5; match to protein family HMM PF05157; bacteriophage N4 adsorption protein B 595787 nfrB 6143790 nfrB Escherichia coli SMS-3-5 bacteriophage N4 adsorption protein B YP_001742684.1 593550 R 439855 CDS YP_001742685.1 170681031 6144506 complement(595937..597379) 1 NC_010498.1 identified by similarity to SP:Q8FK37; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386; sensor kinase CusS 597379 cusS 6144506 cusS Escherichia coli SMS-3-5 sensor kinase CusS YP_001742685.1 595937 R 439855 CDS YP_001742686.1 170681461 6145212 complement(597369..598052) 1 NC_010498.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 598052 cusR 6145212 cusR Escherichia coli SMS-3-5 DNA-binding transcriptional activator CusR YP_001742686.1 597369 R 439855 CDS YP_001742687.1 170684147 6145646 598099..598254 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 598254 6145646 EcSMS35_0589 Escherichia coli SMS-3-5 hypothetical protein YP_001742687.1 598099 D 439855 CDS YP_001742688.1 170682284 6143447 598209..599591 1 NC_010498.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 599591 cusC 6143447 cusC Escherichia coli SMS-3-5 copper/silver efflux system outer membrane protein CusC YP_001742688.1 598209 D 439855 CDS YP_001742689.1 170680156 6146483 599615..599947 1 NC_010498.1 periplasmic copper-binding protein 599947 cusF 6146483 cusF Escherichia coli SMS-3-5 periplasmic copper-binding protein YP_001742689.1 599615 D 439855 CDS YP_001742690.1 170684052 6144322 599963..601186 1 NC_010498.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 601186 cusB 6144322 cusB Escherichia coli SMS-3-5 copper/silver efflux system membrane fusion protein CusB YP_001742690.1 599963 D 439855 CDS YP_001742691.1 170682450 6143351 601198..604341 1 NC_010498.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00914; cation efflux system protein cusA 604341 cusA 6143351 cusA Escherichia coli SMS-3-5 cation efflux system protein cusA YP_001742691.1 601198 D 439855 CDS YP_001742692.1 170683004 6146649 604443..605819 1 NC_010498.1 identified by match to protein family HMM PF00324; phenylalanine transporter 605819 pheP 6146649 pheP Escherichia coli SMS-3-5 phenylalanine transporter YP_001742692.1 604443 D 439855 CDS YP_001742693.1 170681714 6147220 complement(605887..607134) 1 NC_010498.1 identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel (MscS) family protein 607134 6147220 EcSMS35_0595 Escherichia coli SMS-3-5 small conductance mechanosensitive ion channel (MscS) family protein YP_001742693.1 605887 R 439855 CDS YP_001742694.1 170680898 6145902 complement(607242..607895) 1 NC_010498.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 607895 nfnB 6145902 nfnB Escherichia coli SMS-3-5 dihydropteridine reductase YP_001742694.1 607242 R 439855 CDS YP_001742695.1 170680636 6145077 complement(607974..608357) 1 NC_010498.1 identified by match to protein family HMM PF04237; hypothetical protein 608357 6145077 EcSMS35_0597 Escherichia coli SMS-3-5 hypothetical protein YP_001742695.1 607974 R 439855 CDS YP_001742696.1 170679894 6144811 complement(608422..608670) 1 NC_010498.1 identified by match to protein family HMM PF06643; putative lipoprotein 608670 6144811 EcSMS35_0598 Escherichia coli SMS-3-5 putative lipoprotein YP_001742696.1 608422 R 439855 CDS YP_001742697.1 170683850 6144056 complement(608736..609854) 1 NC_010498.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 609854 6144056 EcSMS35_0599 Escherichia coli SMS-3-5 carboxylate-amine ligase YP_001742697.1 608736 R 439855 CDS YP_001742698.1 170683298 6143144 610296..610448 1 NC_010498.1 identified by match to protein family HMM PF01848; Hok/Gef family protein 610448 6143144 EcSMS35_0600 Escherichia coli SMS-3-5 Hok/Gef family protein YP_001742698.1 610296 D 439855 CDS YP_001742699.1 170682382 6147524 complement(610570..611190) 1 NC_010498.1 identified by match to protein family HMM PF01648; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 611190 entD 6147524 entD Escherichia coli SMS-3-5 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_001742699.1 610570 R 439855 CDS YP_001742700.1 170680124 6146581 complement(611365..613605) 1 NC_010498.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 613605 fepA 6146581 fepA Escherichia coli SMS-3-5 outer membrane receptor FepA YP_001742700.1 611365 R 439855 CDS YP_001742701.1 170684078 6144289 613598..613729 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 613729 6144289 EcSMS35_0603 Escherichia coli SMS-3-5 hypothetical protein YP_001742701.1 613598 D 439855 CDS YP_001742702.1 170681399 6143378 613848..615050 1 NC_010498.1 identified by match to protein family HMM PF00756; enterobactin/ferric enterobactin esterase 615050 fes 6143378 fes Escherichia coli SMS-3-5 enterobactin/ferric enterobactin esterase YP_001742702.1 613848 D 439855 CDS YP_001742703.1 170681315 6145583 615053..615271 1 NC_010498.1 identified by match to protein family HMM PF03621; mbtH-like protein 615271 6145583 EcSMS35_0605 Escherichia coli SMS-3-5 mbtH-like protein YP_001742703.1 615053 D 439855 CDS YP_001742704.1 170682592 6145499 615268..619149 1 NC_010498.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 619149 entF 6145499 entF Escherichia coli SMS-3-5 enterobactin synthase subunit F YP_001742704.1 615268 D 439855 CDS YP_001742705.1 170682966 6146797 619364..620497 1 NC_010498.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 620497 fepE 6146797 fepE Escherichia coli SMS-3-5 ferric enterobactin transport protein FepE YP_001742705.1 619364 D 439855 CDS YP_001742706.1 170681920 6147181 complement(620494..621309) 1 NC_010498.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 621309 fepC 6147181 fepC Escherichia coli SMS-3-5 iron-enterobactin transporter ATP-binding protein YP_001742706.1 620494 R 439855 CDS YP_001742707.1 170682765 6146115 complement(621306..622298) 1 NC_010498.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 622298 fepG 6146115 fepG Escherichia coli SMS-3-5 iron-enterobactin transporter permease YP_001742707.1 621306 R 439855 CDS YP_001742708.1 170684313 6146974 complement(622295..623299) 1 NC_010498.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 623299 fepD 6146974 fepD Escherichia coli SMS-3-5 iron-enterobactin transporter membrane protein YP_001742708.1 622295 R 439855 CDS YP_001742709.1 170683623 6143615 623410..624660 1 NC_010498.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 624660 6143615 EcSMS35_0611 Escherichia coli SMS-3-5 enterobactin exporter EntS YP_001742709.1 623410 D 439855 CDS YP_001742710.1 170682097 6142913 complement(624664..625620) 1 NC_010498.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 625620 fepB 6142913 fepB Escherichia coli SMS-3-5 iron-enterobactin transporter periplasmic binding protein YP_001742710.1 624664 R 439855 CDS YP_001742711.1 170684126 6146295 625809..626984 1 NC_010498.1 identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543; isochorismate synthase, entC 626984 entC 6146295 entC Escherichia coli SMS-3-5 isochorismate synthase, entC YP_001742711.1 625809 D 439855 CDS YP_001742712.1 170681611 6143426 626994..628604 1 NC_010498.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 628604 entE 6143426 entE Escherichia coli SMS-3-5 enterobactin synthase subunit E YP_001742712.1 626994 D 439855 CDS YP_001742713.1 170681269 6145796 628618..629475 1 NC_010498.1 identified by similarity to SP:P0ADI4; match to protein family HMM PF00550; match to protein family HMM PF00857; isochorismatase 629475 entB 6145796 entB Escherichia coli SMS-3-5 isochorismatase YP_001742713.1 628618 D 439855 CDS YP_001742714.1 170680585 6145453 629475..630221 1 NC_010498.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 630221 entA 6145453 entA Escherichia coli SMS-3-5 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_001742714.1 629475 D 439855 CDS YP_001742715.1 170680071 6144755 630224..630637 1 NC_010498.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 630637 6144755 EcSMS35_0617 Escherichia coli SMS-3-5 hypothetical protein YP_001742715.1 630224 D 439855 CDS YP_001742716.1 170680351 6144235 630818..632923 1 NC_010498.1 identified by match to protein family HMM PF02554; carbon starvation protein A 632923 cstA 6144235 cstA Escherichia coli SMS-3-5 carbon starvation protein A YP_001742716.1 630818 D 439855 CDS YP_001742717.1 170679838 6144519 633036..633233 1 NC_010498.1 identified by match to protein family HMM PF04328; hypothetical protein 633233 6144519 EcSMS35_0619 Escherichia coli SMS-3-5 hypothetical protein YP_001742717.1 633036 D 439855 CDS YP_001742718.1 170684067 6144000 complement(633243..634331) 1 NC_010498.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 634331 6144000 EcSMS35_0620 Escherichia coli SMS-3-5 hypothetical protein YP_001742718.1 633243 R 439855 CDS YP_001742719.1 170683545 6143367 634440..635600 1 NC_010498.1 catalyzes the transfer of an amino moiety; putative aminotransferase 635600 6143367 EcSMS35_0621 Escherichia coli SMS-3-5 putative aminotransferase YP_001742719.1 634440 D 439855 CDS YP_001742720.1 170683718 6142835 complement(635601..636218) 1 NC_010498.1 identified by similarity to GB:AAM53134.1; match to protein family HMM PF02195; immunoglobulin-binding regulator family protein 636218 6142835 EcSMS35_0622 Escherichia coli SMS-3-5 immunoglobulin-binding regulator family protein YP_001742720.1 635601 R 439855 CDS YP_001742721.1 170680017 6143010 complement(636203..637423) 1 NC_010498.1 identified by match to protein family HMM PF01507; phosphoadenosine phosphosulfate reductase family protein 637423 6143010 EcSMS35_0623 Escherichia coli SMS-3-5 phosphoadenosine phosphosulfate reductase family protein YP_001742721.1 636203 R 439855 CDS YP_001742722.1 170683688 6144180 complement(637570..638472) 1 NC_010498.1 identified by match to protein family HMM PF00126; LysR family transcriptional regulator 638472 6144180 EcSMS35_0624 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742722.1 637570 R 439855 CDS YP_001742723.1 170684088 6142980 complement(638677..639483) 1 NC_010498.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 639483 dsbG 6142980 dsbG Escherichia coli SMS-3-5 disulfide isomerase/thiol-disulfide oxidase YP_001742723.1 638677 R 439855 CDS YP_001742724.1 170682241 6143388 639795..640358 1 NC_010498.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 640358 ahpC 6143388 ahpC Escherichia coli SMS-3-5 alkyl hydroperoxide reductase subunit C YP_001742724.1 639795 D 439855 CDS YP_001742725.1 170682192 6146440 640457..642052 1 NC_010498.1 identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR03140; alkyl hydroperoxide reductase subunit F 642052 ahpF 6146440 ahpF Escherichia coli SMS-3-5 alkyl hydroperoxide reductase subunit F YP_001742725.1 640457 D 439855 CDS YP_001742726.1 170681026 6146391 complement(642173..642601) 1 NC_010498.1 identified by match to protein family HMM PF00582; universal stress protein G 642601 uspG 6146391 uspG Escherichia coli SMS-3-5 universal stress protein G YP_001742726.1 642173 R 439855 CDS YP_001742727.1 170681529 6145207 complement(642957..643367) 1 NC_010498.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 643367 rnk 6145207 rnk Escherichia coli SMS-3-5 nucleoside diphosphate kinase regulator YP_001742727.1 642957 R 439855 CDS YP_001742728.1 170679706 6145714 complement(643597..644403) 1 NC_010498.1 identified by match to protein family HMM PF00445; ribonuclease I 644403 rna 6145714 rna Escherichia coli SMS-3-5 ribonuclease I YP_001742728.1 643597 R 439855 CDS YP_001742729.1 170680678 6143864 complement(644517..645947) 1 NC_010498.1 identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; sodium:sulfate symporter family protein 645947 6143864 EcSMS35_0631 Escherichia coli SMS-3-5 sodium:sulfate symporter family protein YP_001742729.1 644517 R 439855 CDS YP_001742730.1 170683009 6144853 complement(646030..646908) 1 NC_010498.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 646908 citG 6144853 citG Escherichia coli SMS-3-5 triphosphoribosyl-dephospho-CoA synthase YP_001742730.1 646030 R 439855 CDS YP_001742731.1 170683256 6147225 complement(646883..647434) 1 NC_010498.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 647434 citX 6147225 citX Escherichia coli SMS-3-5 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase YP_001742731.1 646883 R 439855 CDS YP_001742732.1 170683977 6147479 complement(647438..648970) 1 NC_010498.1 identified by match to protein family HMM PF04223; match to protein family HMM TIGR01584; citrate lyase, alpha subunit 648970 citF 6147479 citF Escherichia coli SMS-3-5 citrate lyase, alpha subunit YP_001742732.1 647438 R 439855 CDS YP_001742733.1 170681923 6143274 complement(648981..649889) 1 NC_010498.1 identified by match to protein family HMM PF03328; match to protein family HMM TIGR01588; citrate (pro-3S)-lyase, beta subunit 649889 citE 6143274 citE Escherichia coli SMS-3-5 citrate (pro-3S)-lyase, beta subunit YP_001742733.1 648981 R 439855 CDS YP_001742734.1 170682642 6146119 complement(649886..650182) 1 NC_010498.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 650182 citD 6146119 citD Escherichia coli SMS-3-5 citrate lyase subunit gamma YP_001742734.1 649886 R 439855 CDS YP_001742735.1 170681316 6146848 complement(650197..651255) 1 NC_010498.1 identified by match to protein family HMM PF00583; match to protein family HMM PF08218; match to protein family HMM TIGR00124; match to protein family HMM TIGR00125; [citrate (pro-3S)-lyase] ligase 651255 citC 6146848 citC Escherichia coli SMS-3-5 [citrate (pro-3S)-lyase] ligase YP_001742735.1 650197 R 439855 CDS YP_001742736.1 170681994 6145500 651634..653292 1 NC_010498.1 identified by match to protein family HMM PF02518; sensor histidine kinase DpiB 653292 dpiB 6145500 dpiB Escherichia coli SMS-3-5 sensor histidine kinase DpiB YP_001742736.1 651634 D 439855 CDS YP_001742737.1 170679964 6146190 653261..653941 1 NC_010498.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 653941 dpiA 6146190 dpiA Escherichia coli SMS-3-5 two-component response regulator DpiA YP_001742737.1 653261 D 439855 CDS YP_001742738.1 170680591 6144126 complement(653982..655367) 1 NC_010498.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 655367 dcuC 6144126 dcuC Escherichia coli SMS-3-5 C4-dicarboxylate transporter DcuC YP_001742738.1 653982 R 439855 CDS YP_001742739.1 170681327 6143361 complement(656167..657159) 1 NC_010498.1 identified by match to protein family HMM PF01609; IS5 transposase 657159 6143361 EcSMS35_0642 Escherichia coli SMS-3-5 IS5 transposase YP_001742739.1 656167 R 439855 CDS YP_001742740.1 170682098 6147009 657890..658099 1 NC_010498.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 658099 cspE 6147009 cspE Escherichia coli SMS-3-5 cold shock protein CspE YP_001742740.1 657890 D 439855 CDS YP_001742741.1 170684133 6146296 complement(658153..658536) 1 NC_010498.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 658536 crcB 6146296 crcB Escherichia coli SMS-3-5 camphor resistance protein CrcB YP_001742741.1 658153 R 439855 CDS YP_001742742.1 170683299 6143433 658632..659420 1 NC_010498.1 identified by match to protein family HMM PF00795; carbon-nitrogen family hydrolase 659420 6143433 EcSMS35_0646 Escherichia coli SMS-3-5 carbon-nitrogen family hydrolase YP_001742742.1 658632 D 439855 CDS YP_001742743.1 170681815 6147525 659549..659752 1 NC_010498.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 659752 tatE 6147525 tatE Escherichia coli SMS-3-5 twin arginine translocase protein E YP_001742743.1 659549 D 439855 CDS YP_001742744.1 170681300 6146008 complement(659853..660818) 1 NC_010498.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 660818 lipA 6146008 lipA Escherichia coli SMS-3-5 lipoyl synthase YP_001742744.1 659853 R 439855 CDS YP_001742745.1 170679981 6145484 complement(661027..661980) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 661980 6145484 EcSMS35_0649 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001742745.1 661027 R 439855 CDS YP_001742746.1 170683874 6144143 complement(662240..662881) 1 NC_010498.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 662881 lipB 6144143 lipB Escherichia coli SMS-3-5 lipoate-protein ligase B YP_001742746.1 662240 R 439855 CDS YP_001742747.1 170681988 6143169 complement(662982..663245) 1 NC_010498.1 identified by match to protein family HMM PF04359; hypothetical protein 663245 6143169 EcSMS35_0651 Escherichia coli SMS-3-5 hypothetical protein YP_001742747.1 662982 R 439855 CDS YP_001742748.1 170683720 6146184 complement(663355..664566) 1 NC_010498.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A 664566 dacA 6146184 dacA Escherichia coli SMS-3-5 D-alanyl-D-alanine carboxypeptidase fraction A YP_001742748.1 663355 R 439855 CDS YP_001742749.1 170683228 6143012 complement(664706..665794) 1 NC_010498.1 identified by match to protein family HMM PF03330; match to protein family HMM PF05036; match to protein family HMM TIGR00413; rare lipoprotein A 665794 rlpA 6143012 rlpA Escherichia coli SMS-3-5 rare lipoprotein A YP_001742749.1 664706 R 439855 CDS YP_001742750.1 170680649 6147449 complement(665805..666917) 1 NC_010498.1 identified by match to protein family HMM PF01098; match to protein family HMM TIGR02210; cell wall shape-determining protein 666917 mrdB 6147449 mrdB Escherichia coli SMS-3-5 cell wall shape-determining protein YP_001742750.1 665805 R 439855 CDS YP_001742751.1 170679724 6144824 complement(666920..668821) 1 NC_010498.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423; penicillin-binding protein 2 668821 mrdA 6144824 mrdA Escherichia coli SMS-3-5 penicillin-binding protein 2 YP_001742751.1 666920 R 439855 CDS YP_001742752.1 170681791 6143882 complement(668852..669319) 1 NC_010498.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 669319 6143882 EcSMS35_0656 Escherichia coli SMS-3-5 rRNA large subunit methyltransferase YP_001742752.1 668852 R 439855 CDS YP_001742753.1 170681282 6145983 complement(669323..669640) 1 NC_010498.1 identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; hypothetical protein 669640 6145983 EcSMS35_0657 Escherichia coli SMS-3-5 hypothetical protein YP_001742753.1 669323 R 439855 CDS YP_001742754.1 170683166 6145466 complement(669900..670511) 1 NC_010498.1 identified by similarity to SP:P52086; match to protein family HMM PF00300; match to protein family HMM TIGR03162; alpha-ribazole phosphatase 670511 cobC 6145466 cobC Escherichia coli SMS-3-5 alpha-ribazole phosphatase YP_001742754.1 669900 R 439855 CDS YP_001742755.1 170682626 6147386 complement(670535..671176) 1 NC_010498.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 671176 nadD 6147386 nadD Escherichia coli SMS-3-5 nicotinic acid mononucleotide adenylyltransferase YP_001742755.1 670535 R 439855 CDS YP_001742756.1 170679792 6146832 complement(671178..672209) 1 NC_010498.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 672209 holA 6146832 holA Escherichia coli SMS-3-5 DNA polymerase III subunit delta YP_001742756.1 671178 R 439855 CDS YP_001742757.1 170680305 6143952 complement(672209..672790) 1 NC_010498.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 672790 6143952 EcSMS35_0661 Escherichia coli SMS-3-5 LPS-assembly lipoprotein RlpB YP_001742757.1 672209 R 439855 CDS YP_001742758.1 170683771 6144473 complement(672805..675387) 1 NC_010498.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 675387 leuS 6144473 leuS Escherichia coli SMS-3-5 leucyl-tRNA synthetase YP_001742758.1 672805 R 439855 CDS YP_001742759.1 170683239 6143063 675622..676104 1 NC_010498.1 identified by match to protein family HMM PF07295; hypothetical protein 676104 6143063 EcSMS35_0663 Escherichia coli SMS-3-5 hypothetical protein YP_001742759.1 675622 D 439855 CDS YP_001742760.1 170682173 6147461 676070..676183 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 676183 6147461 EcSMS35_0665 Escherichia coli SMS-3-5 hypothetical protein YP_001742760.1 676070 D 439855 CDS YP_001742761.1 170682713 6146372 complement(676175..677152) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 677152 6146372 EcSMS35_0664 Escherichia coli SMS-3-5 hypothetical protein YP_001742761.1 676175 R 439855 CDS YP_001742762.1 170679998 6146921 677316..678023 1 NC_010498.1 identified by match to protein family HMM PF06889; hypothetical protein 678023 6146921 EcSMS35_0666 Escherichia coli SMS-3-5 hypothetical protein YP_001742762.1 677316 D 439855 CDS YP_001742763.1 170681689 6144160 678020..679447 1 NC_010498.1 identified by match to protein family HMM PF00226; DnaJ domain-containing protein 679447 6144160 EcSMS35_0667 Escherichia coli SMS-3-5 DnaJ domain-containing protein YP_001742763.1 678020 D 439855 CDS YP_001742764.1 170683560 6145875 complement(679457..680011) 1 NC_010498.1 identified by match to protein family HMM PF08238; hypothetical protein 680011 6145875 EcSMS35_0668 Escherichia coli SMS-3-5 hypothetical protein YP_001742764.1 679457 R 439855 CDS YP_001742765.1 170680251 6142850 680113..680820 1 NC_010498.1 identified by match to protein family HMM PF06889; hypothetical protein 680820 6142850 EcSMS35_0669 Escherichia coli SMS-3-5 hypothetical protein YP_001742765.1 680113 D 439855 CDS YP_001742766.1 170681976 6144418 680817..682268 1 NC_010498.1 identified by match to protein family HMM PF00226; DnaJ domain-containing protein 682268 6144418 EcSMS35_0670 Escherichia coli SMS-3-5 DnaJ domain-containing protein YP_001742766.1 680817 D 439855 CDS YP_001742767.1 170683933 6146172 complement(682379..684049) 1 NC_010498.1 identified by match to protein family HMM PF00012; DnaK family protein HscC 684049 hscC 6146172 hscC Escherichia coli SMS-3-5 DnaK family protein HscC YP_001742767.1 682379 R 439855 CDS YP_001742768.1 170684012 6143229 complement(684133..685068) 1 NC_010498.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 685068 rihA 6143229 rihA Escherichia coli SMS-3-5 ribonucleoside hydrolase 1 YP_001742768.1 684133 R 439855 CDS YP_001742769.1 170680355 6143311 complement(685186..685911) 1 NC_010498.1 identified by match to protein family HMM PF00005; glutamate/aspartate ABC transporter ATP-binding protein 685911 gltL 6143311 gltL Escherichia coli SMS-3-5 glutamate/aspartate ABC transporter ATP-binding protein YP_001742769.1 685186 R 439855 CDS YP_001742770.1 170683230 6144523 complement(685911..686585) 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamate/aspartate ABC transporter permease GltK 686585 gltK 6144523 gltK Escherichia coli SMS-3-5 glutamate/aspartate ABC transporter permease GltK YP_001742770.1 685911 R 439855 CDS YP_001742771.1 170681365 6147451 complement(686585..687325) 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamate/aspartate ABC transporter permease GltJ 687325 gltJ 6147451 gltJ Escherichia coli SMS-3-5 glutamate/aspartate ABC transporter permease GltJ YP_001742771.1 686585 R 439855 CDS YP_001742772.1 170680102 6145549 complement(687495..688403) 1 NC_010498.1 identified by match to protein family HMM PF00497; glutamate and aspartate transporter subunit 688403 gltI 6145549 gltI Escherichia coli SMS-3-5 glutamate and aspartate transporter subunit YP_001742772.1 687495 R 439855 CDS YP_001742773.1 170683011 6144266 complement(688546..688665) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 688665 6144266 EcSMS35_0677 Escherichia coli SMS-3-5 hypothetical protein YP_001742773.1 688546 R 439855 CDS YP_001742774.1 170682189 6147227 688693..688815 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 688815 6147227 EcSMS35_0679 Escherichia coli SMS-3-5 hypothetical protein YP_001742774.1 688693 D 439855 CDS YP_001742775.1 170681081 6146388 complement(688800..690338) 1 NC_010498.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 690338 lnt 6146388 lnt Escherichia coli SMS-3-5 apolipoprotein N-acyltransferase YP_001742775.1 688800 R 439855 CDS YP_001742776.1 170682729 6145263 complement(690363..691241) 1 NC_010498.1 identified by match to protein family HMM PF00571; match to protein family HMM PF03471; magnesium and cobalt efflux protein CorC 691241 corC 6145263 corC Escherichia coli SMS-3-5 magnesium and cobalt efflux protein CorC YP_001742776.1 690363 R 439855 CDS YP_001742777.1 170681098 6146937 complement(691331..691798) 1 NC_010498.1 identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease 691798 6146937 EcSMS35_0681 Escherichia coli SMS-3-5 putative metalloprotease YP_001742777.1 691331 R 439855 CDS YP_001742778.1 170681748 6145280 complement(691795..692835) 1 NC_010498.1 identified by match to protein family HMM PF02562; PhoH family protein 692835 6145280 EcSMS35_0682 Escherichia coli SMS-3-5 PhoH family protein YP_001742778.1 691795 R 439855 CDS YP_001742779.1 170681910 6145938 complement(692894..693013) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 693013 6145938 EcSMS35_0683 Escherichia coli SMS-3-5 hypothetical protein YP_001742779.1 692894 R 439855 CDS YP_001742780.1 170679912 6146105 complement(692988..694412) 1 NC_010498.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 694412 miaB 6146105 miaB Escherichia coli SMS-3-5 (dimethylallyl)adenosine tRNA methylthiotransferase YP_001742780.1 692988 R 439855 CDS YP_001742781.1 170680248 6144074 694558..695733 1 NC_010498.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 695733 ubiF 6144074 ubiF Escherichia coli SMS-3-5 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_001742781.1 694558 D 439855 CDS YP_001742782.1 170683596 6143656 complement(697033..698697) 1 NC_010498.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 698697 asnB 6143656 asnB Escherichia coli SMS-3-5 asparagine synthetase B YP_001742782.1 697033 R 439855 CDS YP_001742783.1 170683151 6142887 698666..698830 1 NC_010498.1 putative lipoprotein 698830 6142887 EcSMS35_0694 Escherichia coli SMS-3-5 putative lipoprotein YP_001742783.1 698666 D 439855 CDS YP_001742784.1 170682309 6147371 complement(698954..699706) 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01460; UMP phosphatase 699706 nagD 6147371 nagD Escherichia coli SMS-3-5 UMP phosphatase YP_001742784.1 698954 R 439855 CDS YP_001742785.1 170681967 6146508 complement(699754..700974) 1 NC_010498.1 identified by match to protein family HMM PF00480; N-acetylglucosamine repressor 700974 nagC 6146508 nagC Escherichia coli SMS-3-5 N-acetylglucosamine repressor YP_001742785.1 699754 R 439855 CDS YP_001742786.1 170682789 6146163 complement(700983..702131) 1 NC_010498.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 702131 nagA 6146163 nagA Escherichia coli SMS-3-5 N-acetylglucosamine-6-phosphate deacetylase YP_001742786.1 700983 R 439855 CDS YP_001742787.1 170682186 6146998 complement(702191..702991) 1 NC_010498.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 702991 nagB 6146998 nagB Escherichia coli SMS-3-5 glucosamine-6-phosphate deaminase YP_001742787.1 702191 R 439855 CDS YP_001742788.1 170682739 6146385 complement(703040..703174) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 703174 6146385 EcSMS35_0699 Escherichia coli SMS-3-5 hypothetical protein YP_001742788.1 703040 R 439855 CDS YP_001742789.1 170681159 6146947 703324..705270 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 705270 nagE 6146947 nagE Escherichia coli SMS-3-5 PTS system N-acetyl glucosamine specific transporter subunits IIABC YP_001742789.1 703324 D 439855 CDS YP_001742790.1 170682742 6145343 complement(705240..705395) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 705395 6145343 EcSMS35_0700 Escherichia coli SMS-3-5 hypothetical protein YP_001742790.1 705240 R 439855 CDS YP_001742791.1 170681669 6146950 705473..707137 1 NC_010498.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 707137 glnS 6146950 glnS Escherichia coli SMS-3-5 glutaminyl-tRNA synthetase YP_001742791.1 705473 D 439855 CDS YP_001742792.1 170680096 6145855 707579..708985 1 NC_010498.1 identified by match to protein family HMM PF03573; OprD family outer membrane porin 708985 6145855 EcSMS35_0703 Escherichia coli SMS-3-5 OprD family outer membrane porin YP_001742792.1 707579 D 439855 CDS YP_001742793.1 170680089 6144260 709035..709361 1 NC_010498.1 putative lipoprotein 709361 6144260 EcSMS35_0704 Escherichia coli SMS-3-5 putative lipoprotein YP_001742793.1 709035 D 439855 CDS YP_001742794.1 170680602 6144253 complement(709445..709891) 1 NC_010498.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 709891 fur 6144253 fur Escherichia coli SMS-3-5 ferric uptake regulator YP_001742794.1 709445 R 439855 CDS YP_001742795.1 170683931 6144776 complement(710180..710710) 1 NC_010498.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 710710 fldA 6144776 fldA Escherichia coli SMS-3-5 flavodoxin FldA YP_001742795.1 710180 R 439855 CDS YP_001742796.1 170681944 6143227 complement(710850..711143) 1 NC_010498.1 identified by match to protein family HMM PF01402; LexA regulated protein 711143 6143227 EcSMS35_0707 Escherichia coli SMS-3-5 LexA regulated protein YP_001742796.1 710850 R 439855 CDS YP_001742797.1 170683869 6146140 complement(711283..712047) 1 NC_010498.1 identified by match to protein family HMM PF00561; match to protein family HMM PF07819; hypothetical protein 712047 ybfF 6146140 ybfF Escherichia coli SMS-3-5 hypothetical protein YP_001742797.1 711283 R 439855 CDS YP_001742798.1 170684136 6143164 712232..712777 1 NC_010498.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 712777 seqA 6143164 seqA Escherichia coli SMS-3-5 replication initiation regulator SeqA YP_001742798.1 712232 D 439855 CDS YP_001742799.1 170682528 6143436 712803..714443 1 NC_010498.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 714443 pgm 6143436 pgm Escherichia coli SMS-3-5 phosphoglucomutase YP_001742799.1 712803 D 439855 CDS YP_001742800.1 170682201 6146729 714648..715142 1 NC_010498.1 YbfP; putative lipoprotein 715142 6146729 EcSMS35_0711 Escherichia coli SMS-3-5 putative lipoprotein YP_001742800.1 714648 D 439855 CDS YP_001742801.1 170680055 6146400 complement(715183..715833) 1 NC_010498.1 identified by similarity to GB:ABB11945.1; hypothetical protein 715833 6146400 EcSMS35_0712 Escherichia coli SMS-3-5 hypothetical protein YP_001742801.1 715183 R 439855 CDS YP_001742802.1 170681346 6144219 complement(715911..716060) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 716060 6144219 EcSMS35_0713 Escherichia coli SMS-3-5 hypothetical protein YP_001742802.1 715911 R 439855 CDS YP_001742803.1 170683462 6145530 complement(716182..717501) 1 NC_010498.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 717501 potE 6145530 potE Escherichia coli SMS-3-5 putrescine transporter YP_001742803.1 716182 R 439855 CDS YP_001742804.1 170680662 6142751 complement(717498..719696) 1 NC_010498.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; ornithine decarboxylase 719696 speF 6142751 speF Escherichia coli SMS-3-5 ornithine decarboxylase YP_001742804.1 717498 R 439855 CDS YP_001742805.1 170682921 6144837 complement(720292..720969) 1 NC_010498.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 720969 kdpE 6144837 kdpE Escherichia coli SMS-3-5 DNA-binding transcriptional activator KdpE YP_001742805.1 720292 R 439855 CDS YP_001742806.1 170682267 6147135 complement(720966..723650) 1 NC_010498.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 723650 kdpD 6147135 kdpD Escherichia coli SMS-3-5 sensor protein KdpD YP_001742806.1 720966 R 439855 CDS YP_001742807.1 170683205 6146466 complement(723643..724215) 1 NC_010498.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 724215 kdpC 6146466 kdpC Escherichia coli SMS-3-5 potassium-transporting ATPase subunit C YP_001742807.1 723643 R 439855 CDS YP_001742808.1 170683609 6147426 complement(724224..726272) 1 NC_010498.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 726272 kdpB 6147426 kdpB Escherichia coli SMS-3-5 potassium-transporting ATPase subunit B YP_001742808.1 724224 R 439855 CDS YP_001742809.1 170681798 6142899 complement(726295..727968) 1 NC_010498.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 727968 kdpA 6142899 kdpA Escherichia coli SMS-3-5 potassium-transporting ATPase subunit A YP_001742809.1 726295 R 439855 CDS YP_001742810.1 170680354 6145991 728370..728576 1 NC_010498.1 hypothetical protein 728576 6145991 EcSMS35_0721 Escherichia coli SMS-3-5 hypothetical protein YP_001742810.1 728370 D 439855 CDS YP_001742811.1 170681025 6144522 728677..729186 1 NC_010498.1 identified by match to protein family HMM PF08349; hypothetical protein 729186 6144522 EcSMS35_0722 Escherichia coli SMS-3-5 hypothetical protein YP_001742811.1 728677 D 439855 CDS YP_001742812.1 170681516 6145206 729183..730601 1 NC_010498.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 730601 phrB 6145206 phrB Escherichia coli SMS-3-5 deoxyribodipyrimidine photolyase YP_001742812.1 729183 D 439855 CDS YP_001742813.1 170682417 6145701 complement(730643..732124) 1 NC_010498.1 identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; amino acid/peptide transporter 732124 6145701 EcSMS35_0724 Escherichia coli SMS-3-5 amino acid/peptide transporter YP_001742813.1 730643 R 439855 CDS YP_001742814.1 170682961 6146616 732395..733138 1 NC_010498.1 identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; putative hydrolase-oxidase 733138 6146616 EcSMS35_0725 Escherichia coli SMS-3-5 putative hydrolase-oxidase YP_001742814.1 732395 D 439855 CDS YP_001742815.1 170683448 6147176 733161..733817 1 NC_010498.1 identified by match to protein family HMM PF02682; match to protein family HMM TIGR00370; allophanate hydrolase, subunit 1 733817 6147176 EcSMS35_0726 Escherichia coli SMS-3-5 allophanate hydrolase, subunit 1 YP_001742815.1 733161 D 439855 CDS YP_001742816.1 170682154 6142735 733811..734743 1 NC_010498.1 identified by match to protein family HMM PF02626; match to protein family HMM TIGR00724; allophanate hydrolase, subunit 2 734743 6142735 EcSMS35_0727 Escherichia coli SMS-3-5 allophanate hydrolase, subunit 2 YP_001742816.1 733811 D 439855 CDS YP_001742817.1 170682277 6146353 734733..735467 1 NC_010498.1 identified by match to protein family HMM PF03746; LamB/YcsF family protein 735467 6146353 EcSMS35_0728 Escherichia coli SMS-3-5 LamB/YcsF family protein YP_001742817.1 734733 D 439855 CDS YP_001742818.1 170683193 6146476 735503..736294 1 NC_010498.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 736294 nei 6146476 nei Escherichia coli SMS-3-5 endonuclease VIII YP_001742818.1 735503 D 439855 CDS YP_001742819.1 170681894 6147413 complement(736291..737337) 1 NC_010498.1 identified by match to protein family HMM PF05145; match to protein family HMM TIGR03082; protein AbrB 737337 abrB 6147413 abrB Escherichia coli SMS-3-5 protein AbrB YP_001742819.1 736291 R 439855 CDS YP_001742820.1 170682648 6146088 complement(737489..737863) 1 NC_010498.1 identified by similarity to GB:AAZ87425.1; hypothetical protein 737863 6146088 EcSMS35_0731 Escherichia coli SMS-3-5 hypothetical protein YP_001742820.1 737489 R 439855 CDS YP_001742821.1 170683629 6146855 complement(738010..739293) 1 NC_010498.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 739293 gltA 6146855 gltA Escherichia coli SMS-3-5 type II citrate synthase YP_001742821.1 738010 R 439855 CDS YP_001742822.1 170679876 6147465 739987..740391 1 NC_010498.1 identified by match to protein family HMM PF01127; match to protein family HMM TIGR02970; succinate dehydrogenase cytochrome b556 large membrane subunit 740391 sdhC 6147465 sdhC Escherichia coli SMS-3-5 succinate dehydrogenase cytochrome b556 large membrane subunit YP_001742822.1 739987 D 439855 CDS YP_001742823.1 170684264 6144038 740385..740732 1 NC_010498.1 identified by match to protein family HMM TIGR02968; succinate dehydrogenase cytochrome b556 small membrane subunit 740732 sdhD 6144038 sdhD Escherichia coli SMS-3-5 succinate dehydrogenase cytochrome b556 small membrane subunit YP_001742823.1 740385 D 439855 CDS YP_001742824.1 170681511 6143566 740732..742498 1 NC_010498.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 742498 sdhA 6143566 sdhA Escherichia coli SMS-3-5 succinate dehydrogenase flavoprotein subunit YP_001742824.1 740732 D 439855 CDS YP_001742825.1 170681087 6145696 742514..743230 1 NC_010498.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 743230 sdhB 6145696 sdhB Escherichia coli SMS-3-5 succinate dehydrogenase iron-sulfur subunit YP_001742825.1 742514 D 439855 CDS YP_001742826.1 170681528 6145269 743431..746232 1 NC_010498.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 746232 sucA 6145269 sucA Escherichia coli SMS-3-5 2-oxoglutarate dehydrogenase E1 component YP_001742826.1 743431 D 439855 CDS YP_001742827.1 170681017 6145713 746247..747464 1 NC_010498.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 747464 sucB 6145713 sucB Escherichia coli SMS-3-5 dihydrolipoamide succinyltransferase YP_001742827.1 746247 D 439855 CDS YP_001742828.1 170683514 6145198 747558..748724 1 NC_010498.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 748724 sucC 6145198 sucC Escherichia coli SMS-3-5 succinyl-CoA synthetase subunit beta YP_001742828.1 747558 D 439855 CDS YP_001742829.1 170682614 6142804 748724..749593 1 NC_010498.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 749593 sucD 6142804 sucD Escherichia coli SMS-3-5 succinyl-CoA synthetase subunit alpha YP_001742829.1 748724 D 439855 CDS YP_001742830.1 170679758 6146820 749842..749988 1 NC_010498.1 identified by similarity to GB:ABM24414.1; hypothetical protein 749988 6146820 EcSMS35_0742 Escherichia coli SMS-3-5 hypothetical protein YP_001742830.1 749842 D 439855 CDS YP_001742831.1 170684102 6143917 750259..751164 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 751164 6143917 EcSMS35_0743 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742831.1 750259 D 439855 CDS YP_001742832.1 170683867 6143402 complement(751198..751800) 1 NC_010498.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 751800 cobO 6143402 cobO Escherichia coli SMS-3-5 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_001742832.1 751198 R 439855 CDS YP_001742833.1 170679952 6143162 complement(751810..753462) 1 NC_010498.1 identified by match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; tartrate/fumarate family Fe-S type hydro-lyase 753462 6143162 EcSMS35_0745 Escherichia coli SMS-3-5 tartrate/fumarate family Fe-S type hydro-lyase YP_001742833.1 751810 R 439855 CDS YP_001742834.1 170680220 6144114 complement(753570..754850) 1 NC_010498.1 identified by similarity to SP:P24943; match to protein family HMM PF00375; dicarboxylate/amino acid:cation family protein 754850 6144114 EcSMS35_0746 Escherichia coli SMS-3-5 dicarboxylate/amino acid:cation family protein YP_001742834.1 753570 R 439855 CDS YP_001742835.1 170680962 6144386 complement(755011..755328) 1 NC_010498.1 identified by similarity to GB:CAL14063.1; hypothetical protein 755328 6144386 EcSMS35_0747 Escherichia coli SMS-3-5 hypothetical protein YP_001742835.1 755011 R 439855 CDS YP_001742836.1 170680011 6145143 complement(755325..756695) 1 NC_010498.1 hypothetical protein 756695 6145143 EcSMS35_0748 Escherichia coli SMS-3-5 hypothetical protein YP_001742836.1 755325 R 439855 CDS YP_001742837.1 170679704 6144174 complement(756699..757940) 1 NC_010498.1 identified by match to protein family HMM PF05034; match to protein family HMM PF07476; match to protein family HMM TIGR01502; methylaspartate ammonia-lyase 757940 6144174 EcSMS35_0749 Escherichia coli SMS-3-5 methylaspartate ammonia-lyase YP_001742837.1 756699 R 439855 CDS YP_001742838.1 170683418 6143862 complement(757940..759385) 1 NC_010498.1 identified by match to protein family HMM PF06368; match to protein family HMM TIGR01503; methylaspartate mutase, E subunit 759385 mutE 6143862 mutE Escherichia coli SMS-3-5 methylaspartate mutase, E subunit YP_001742838.1 757940 R 439855 CDS YP_001742839.1 170682898 6142704 complement(759404..760792) 1 NC_010498.1 identified by similarity to GB:BAB34186.1; match to protein family HMM TIGR01319; putative glutamate mutase mutL 760792 6142704 EcSMS35_0751 Escherichia coli SMS-3-5 putative glutamate mutase mutL YP_001742839.1 759404 R 439855 CDS YP_001742840.1 170683428 6147111 complement(760792..761241) 1 NC_010498.1 converts methylaspartate to L-glutamate; methylaspartate mutase subunit S 761241 mamA 6147111 mamA Escherichia coli SMS-3-5 methylaspartate mutase subunit S YP_001742840.1 760792 R 439855 CDS YP_001742841.1 170683089 6142715 complement(761788..762210) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 762210 6142715 EcSMS35_0753 Escherichia coli SMS-3-5 hypothetical protein YP_001742841.1 761788 R 439855 CDS YP_001742842.1 170682407 6147306 complement(762291..763235) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 763235 6147306 EcSMS35_0754 Escherichia coli SMS-3-5 hypothetical protein YP_001742842.1 762291 R 439855 CDS YP_001742843.1 170681426 6146606 764041..765609 1 NC_010498.1 identified by match to protein family HMM PF01654; cytochrome d ubiquinol oxidase, subunit I 765609 cydA 6146606 cydA Escherichia coli SMS-3-5 cytochrome d ubiquinol oxidase, subunit I YP_001742843.1 764041 D 439855 CDS YP_001742844.1 170680777 6145610 765625..766764 1 NC_010498.1 identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203; cytochrome d ubiquinol oxidase, subunit II 766764 cydB1 6145610 cydB1 Escherichia coli SMS-3-5 cytochrome d ubiquinol oxidase, subunit II YP_001742844.1 765625 D 439855 CDS YP_001742845.1 170680381 6144952 766779..766892 1 NC_010498.1 identified by match to protein family HMM PF08173; match to protein family HMM TIGR02106; cyd operon protein YbgT 766892 6144952 EcSMS35_0757 Escherichia coli SMS-3-5 cyd operon protein YbgT YP_001742845.1 766779 D 439855 CDS YP_001742846.1 170682052 6144550 766892..767185 1 NC_010498.1 identified by match to protein family HMM TIGR02112; hypothetical protein 767185 6144550 EcSMS35_0758 Escherichia coli SMS-3-5 hypothetical protein YP_001742846.1 766892 D 439855 CDS YP_001742847.1 170681363 6146249 767335..767739 1 NC_010498.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 767739 ybgC 6146249 ybgC Escherichia coli SMS-3-5 acyl-CoA thioester hydrolase YbgC YP_001742847.1 767335 D 439855 CDS YP_001742848.1 170681028 6145547 767736..768428 1 NC_010498.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 768428 tolQ 6145547 tolQ Escherichia coli SMS-3-5 colicin uptake protein TolQ YP_001742848.1 767736 D 439855 CDS YP_001742849.1 170680358 6145209 768432..768860 1 NC_010498.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 768860 tolR 6145209 tolR Escherichia coli SMS-3-5 colicin uptake protein TolR YP_001742849.1 768432 D 439855 CDS YP_001742850.1 170684137 6144526 768925..770205 1 NC_010498.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 770205 tolA 6144526 tolA Escherichia coli SMS-3-5 cell envelope integrity inner membrane protein TolA YP_001742850.1 768925 D 439855 CDS YP_001742851.1 170683440 6143437 770335..771630 1 NC_010498.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 771630 tolB 6143437 tolB Escherichia coli SMS-3-5 translocation protein TolB YP_001742851.1 770335 D 439855 CDS YP_001742852.1 170683065 6142727 771665..772186 1 NC_010498.1 identified by match to protein family HMM PF00691; match to protein family HMM TIGR02802; peptidoglycan-associated outer membrane lipoprotein 772186 pal 6142727 pal Escherichia coli SMS-3-5 peptidoglycan-associated outer membrane lipoprotein YP_001742852.1 771665 D 439855 CDS YP_001742853.1 170682384 6147282 772196..772987 1 NC_010498.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 772987 ygbF 6147282 ygbF Escherichia coli SMS-3-5 tol-pal system protein YbgF YP_001742853.1 772196 D 439855 CDS YP_001742854.1 170682003 6143637 774104..775147 1 NC_010498.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 775147 nadA 6143637 nadA Escherichia coli SMS-3-5 quinolinate synthetase YP_001742854.1 774104 D 439855 CDS YP_001742855.1 170680442 6146199 775185..775904 1 NC_010498.1 identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter PnuC 775904 pnuC 6146199 pnuC Escherichia coli SMS-3-5 nicotinamide mononucleotide transporter PnuC YP_001742855.1 775185 D 439855 CDS YP_001742856.1 170683559 6147423 complement(776956..777336) 1 NC_010498.1 hypothetical protein 777336 6147423 EcSMS35_0776 Escherichia coli SMS-3-5 hypothetical protein YP_001742856.1 776956 R 439855 CDS YP_001742857.1 170684235 6142849 777652..778704 1 NC_010498.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 778704 aroG 6142849 aroG Escherichia coli SMS-3-5 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001742857.1 777652 D 439855 CDS YP_001742858.1 170681144 6143536 complement(778852..779604) 1 NC_010498.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 779604 gpmA 6143536 gpmA Escherichia coli SMS-3-5 phosphoglyceromutase YP_001742858.1 778852 R 439855 CDS YP_001742859.1 170681719 6145327 complement(779807..780847) 1 NC_010498.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 780847 galM 6145327 galM Escherichia coli SMS-3-5 aldose 1-epimerase YP_001742859.1 779807 R 439855 CDS YP_001742860.1 170679731 6145907 complement(780841..781989) 1 NC_010498.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 781989 galK 6145907 galK Escherichia coli SMS-3-5 galactokinase YP_001742860.1 780841 R 439855 CDS YP_001742861.1 170680663 6143889 complement(781993..783039) 1 NC_010498.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 783039 galT 6143889 galT Escherichia coli SMS-3-5 galactose-1-phosphate uridylyltransferase YP_001742861.1 781993 R 439855 CDS YP_001742862.1 170683375 6144838 complement(783049..784065) 1 NC_010498.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF05368; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-galactose-4-epimerase 784065 galE 6144838 galE Escherichia coli SMS-3-5 UDP-galactose-4-epimerase YP_001742862.1 783049 R 439855 CDS YP_001742863.1 170683734 6142661 complement(784327..785799) 1 NC_010498.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF 785799 modF 6142661 modF Escherichia coli SMS-3-5 putative molybdenum transport ATP-binding protein ModF YP_001742863.1 784327 R 439855 CDS YP_001742864.1 170680486 6143026 complement(785867..786655) 1 NC_010498.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 786655 modE 6143026 modE Escherichia coli SMS-3-5 DNA-binding transcriptional regulator ModE YP_001742864.1 785867 R 439855 CDS YP_001742865.1 170683661 6144655 786784..786933 1 NC_010498.1 hypothetical protein 786933 6144655 EcSMS35_0785 Escherichia coli SMS-3-5 hypothetical protein YP_001742865.1 786784 D 439855 CDS YP_001742866.1 170683313 6142953 787100..787873 1 NC_010498.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 787873 modA 6142953 modA Escherichia coli SMS-3-5 molybdate transporter periplasmic protein YP_001742866.1 787100 D 439855 CDS YP_001742867.1 170682360 6142598 787873..788562 1 NC_010498.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 788562 modB 6142598 modB Escherichia coli SMS-3-5 molybdate ABC transporter permease YP_001742867.1 787873 D 439855 CDS YP_001742868.1 170682023 6146559 788565..789623 1 NC_010498.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 789623 modC 6146559 modC Escherichia coli SMS-3-5 molybdate transporter ATP-binding protein YP_001742868.1 788565 D 439855 CDS YP_001742869.1 170682522 6146220 complement(789624..790442) 1 NC_010498.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 790442 ybhA 6146220 ybhA Escherichia coli SMS-3-5 phosphotransferase YP_001742869.1 789624 R 439855 CDS YP_001742870.1 170679786 6146723 790597..791592 1 NC_010498.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 791592 pgl 6146723 pgl Escherichia coli SMS-3-5 6-phosphogluconolactonase YP_001742870.1 790597 D 439855 CDS YP_001742871.1 170680416 6143946 complement(791633..792586) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 792586 6143946 EcSMS35_0791 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001742871.1 791633 R 439855 CDS YP_001742872.1 170683357 6144585 792770..793822 1 NC_010498.1 identified by match to protein family HMM PF04303; hypothetical protein 793822 6144585 EcSMS35_0792 Escherichia coli SMS-3-5 hypothetical protein YP_001742872.1 792770 D 439855 CDS YP_001742873.1 170683868 6142643 793898..795331 1 NC_010498.1 identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; anion transporter 795331 6142643 EcSMS35_0793 Escherichia coli SMS-3-5 anion transporter YP_001742873.1 793898 D 439855 CDS YP_001742874.1 170683967 6143163 795514..797775 1 NC_010498.1 identified by match to protein family HMM PF00330; match to protein family HMM PF00694; hypothetical protein 797775 6143163 EcSMS35_0794 Escherichia coli SMS-3-5 hypothetical protein YP_001742874.1 795514 D 439855 CDS YP_001742875.1 170683447 6143264 complement(797846..799129) 1 NC_010498.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase 799129 6143264 EcSMS35_0795 Escherichia coli SMS-3-5 putative pectinesterase YP_001742875.1 797846 R 439855 CDS YP_001742876.1 170680241 6142734 complement(799281..799757) 1 NC_010498.1 YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein 799757 6142734 EcSMS35_0796 Escherichia coli SMS-3-5 putative kinase inhibitor protein YP_001742876.1 799281 R 439855 CDS YP_001742877.1 170679840 6144408 complement(799816..801168) 1 NC_010498.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 801168 bioA 6144408 bioA Escherichia coli SMS-3-5 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_001742877.1 799816 R 439855 CDS YP_001742878.1 170680651 6144002 801192..802232 1 NC_010498.1 identified by match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR00433; biotin synthase 802232 bioB 6144002 bioB Escherichia coli SMS-3-5 biotin synthase YP_001742878.1 801192 D 439855 CDS YP_001742879.1 170680137 6144826 802229..803383 1 NC_010498.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 803383 bioF 6144826 bioF Escherichia coli SMS-3-5 8-amino-7-oxononanoate synthase YP_001742879.1 802229 D 439855 CDS YP_001742880.1 170681622 6144303 803370..804125 1 NC_010498.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 804125 bioC 6144303 bioC Escherichia coli SMS-3-5 biotin biosynthesis protein BioC YP_001742880.1 803370 D 439855 CDS YP_001742881.1 170681047 6145807 804118..804795 1 NC_010498.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 804795 bioD 6145807 bioD Escherichia coli SMS-3-5 dithiobiotin synthetase YP_001742881.1 804118 D 439855 CDS YP_001742882.1 170682296 6145228 805374..807395 1 NC_010498.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 807395 uvrB 6145228 uvrB Escherichia coli SMS-3-5 excinuclease ABC subunit B YP_001742882.1 805374 D 439855 CDS YP_001742883.1 170683940 6146495 complement(807433..808341) 1 NC_010498.1 identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; hypothetical protein 808341 6146495 EcSMS35_0803 Escherichia coli SMS-3-5 hypothetical protein YP_001742883.1 807433 R 439855 CDS YP_001742884.1 170682341 6143236 808738..809727 1 NC_010498.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 809727 moaA 6143236 moaA Escherichia coli SMS-3-5 molybdenum cofactor biosynthesis protein A YP_001742884.1 808738 D 439855 CDS YP_001742885.1 170683590 6146540 809749..810261 1 NC_010498.1 identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR02667; molybdenum cofactor biosynthesis protein B 810261 moaB 6146540 moaB Escherichia coli SMS-3-5 molybdenum cofactor biosynthesis protein B YP_001742885.1 809749 D 439855 CDS YP_001742886.1 170683140 6142881 810264..810749 1 NC_010498.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 810749 moaC 6142881 moaC Escherichia coli SMS-3-5 molybdenum cofactor biosynthesis protein MoaC YP_001742886.1 810264 D 439855 CDS YP_001742887.1 170683802 6147360 810742..810987 1 NC_010498.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 810987 moaD 6147360 moaD Escherichia coli SMS-3-5 molybdopterin synthase small subunit YP_001742887.1 810742 D 439855 CDS YP_001742888.1 170679739 6143096 810989..811441 1 NC_010498.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 811441 moaE 6143096 moaE Escherichia coli SMS-3-5 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_001742888.1 810989 D 439855 CDS YP_001742889.1 170680930 6143897 811578..812282 1 NC_010498.1 identified by match to protein family HMM PF01027; hypothetical protein 812282 6143897 EcSMS35_0809 Escherichia coli SMS-3-5 hypothetical protein YP_001742889.1 811578 D 439855 CDS YP_001742890.1 170681584 6145111 812489..813202 1 NC_010498.1 identified by match to protein family HMM PF01027; hypothetical protein 813202 6145111 EcSMS35_0810 Escherichia coli SMS-3-5 hypothetical protein YP_001742890.1 812489 D 439855 CDS YP_001742891.1 170682288 6145769 complement(813238..814194) 1 NC_010498.1 hypothetical protein 814194 6145769 EcSMS35_0811 Escherichia coli SMS-3-5 hypothetical protein YP_001742891.1 813238 R 439855 CDS YP_001742892.1 170682929 6146487 complement(814194..815435) 1 NC_010498.1 identified by match to protein family HMM PF00614; cardiolipin synthase 2 815435 6146487 EcSMS35_0812 Escherichia coli SMS-3-5 cardiolipin synthase 2 YP_001742892.1 814194 R 439855 CDS YP_001742893.1 170684095 6147143 complement(815432..816193) 1 NC_010498.1 identified by match to protein family HMM PF03372; endonuclease/exonuclease/phosphatase family protein 816193 6147143 EcSMS35_0813 Escherichia coli SMS-3-5 endonuclease/exonuclease/phosphatase family protein YP_001742893.1 815432 R 439855 CDS YP_001742894.1 170682149 6143395 816326..816736 1 NC_010498.1 hypothetical protein 816736 6143395 EcSMS35_0815 Escherichia coli SMS-3-5 hypothetical protein YP_001742894.1 816326 D 439855 CDS YP_001742895.1 170683835 6146348 complement(816698..817804) 1 NC_010498.1 identified by match to protein family HMM PF01061; ABC-2 type transporter, permease 817804 6146348 EcSMS35_0814 Escherichia coli SMS-3-5 ABC-2 type transporter, permease YP_001742895.1 816698 R 439855 CDS YP_001742896.1 170679866 6143129 complement(817815..818948) 1 NC_010498.1 identified by match to protein family HMM PF01061; ABC-2 type transporter, permease 818948 6143129 EcSMS35_0816 Escherichia coli SMS-3-5 ABC-2 type transporter, permease YP_001742896.1 817815 R 439855 CDS YP_001742897.1 170680534 6144028 complement(818941..820677) 1 NC_010498.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 820677 6144028 EcSMS35_0817 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001742897.1 818941 R 439855 CDS YP_001742898.1 170683048 6144704 complement(820670..821665) 1 NC_010498.1 identified by match to protein family HMM PF00529; hypothetical protein 821665 6144704 EcSMS35_0818 Escherichia coli SMS-3-5 hypothetical protein YP_001742898.1 820670 R 439855 CDS YP_001742899.1 170681317 6147264 complement(821668..822339) 1 NC_010498.1 identified by match to protein family HMM PF00440; match to protein family HMM PF09209; putative DNA-binding transcriptional regulator 822339 6147264 EcSMS35_0819 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001742899.1 821668 R 439855 CDS YP_001742900.1 170683710 6145501 822568..823932 1 NC_010498.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 823932 6145501 EcSMS35_0820 Escherichia coli SMS-3-5 ATP-dependent RNA helicase RhlE YP_001742900.1 822568 D 439855 CDS YP_001742901.1 170682108 6143002 824089..824529 1 NC_010498.1 RelB/DinJ family addiction module antitoxin 824529 6143002 EcSMS35_0821 Escherichia coli SMS-3-5 RelB/DinJ family addiction module antitoxin YP_001742901.1 824089 D 439855 CDS YP_001742902.1 170683281 6146306 824529..824810 1 NC_010498.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; RelE/ParE family addiction module toxin 824810 6146306 EcSMS35_0822 Escherichia coli SMS-3-5 RelE/ParE family addiction module toxin YP_001742902.1 824529 D 439855 CDS YP_001742903.1 170683984 6147507 824981..827131 1 NC_010498.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 827131 dinG 6147507 dinG Escherichia coli SMS-3-5 ATP-dependent DNA helicase DinG YP_001742903.1 824981 D 439855 CDS YP_001742904.1 170682285 6143282 827159..828121 1 NC_010498.1 identified by match to protein family HMM PF02885; glycosyl transferase family protein 828121 6143282 EcSMS35_0824 Escherichia coli SMS-3-5 glycosyl transferase family protein YP_001742904.1 827159 D 439855 CDS YP_001742905.1 170682957 6146484 828262..829347 1 NC_010498.1 identified by match to protein family HMM PF02615; hypothetical protein 829347 6146484 EcSMS35_0825 Escherichia coli SMS-3-5 hypothetical protein YP_001742905.1 828262 D 439855 CDS YP_001742906.1 170683570 6147172 complement(829487..829747) 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 829747 6147172 EcSMS35_0826 Escherichia coli SMS-3-5 hypothetical protein YP_001742906.1 829487 R 439855 CDS YP_001742907.1 170684263 6142861 complement(830012..830278) 1 NC_010498.1 identified by match to protein family HMM PF01258; match to protein family HMM TIGR02419; hypothetical protein 830278 6142861 EcSMS35_0827 Escherichia coli SMS-3-5 hypothetical protein YP_001742907.1 830012 R 439855 CDS YP_001742908.1 170681313 6143565 complement(830352..831029) 1 NC_010498.1 identified by match to protein family HMM PF03171; putative hydroxylase 831029 6143565 EcSMS35_0828 Escherichia coli SMS-3-5 putative hydroxylase YP_001742908.1 830352 R 439855 CDS YP_001742909.1 170681668 6145497 complement(831071..833353) 1 NC_010498.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 833353 fiu 6145497 fiu Escherichia coli SMS-3-5 catecholate siderophore receptor Fiu YP_001742909.1 831071 R 439855 CDS YP_001742910.1 170680063 6145854 complement(833618..833878) 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 833878 6145854 EcSMS35_0830 Escherichia coli SMS-3-5 hypothetical protein YP_001742910.1 833618 R 439855 CDS YP_001742911.1 170683739 6144227 834154..835080 1 NC_010498.1 identified by match to protein family HMM PF05971; putative SAM-dependent methyltransferase 835080 6144227 EcSMS35_0832 Escherichia coli SMS-3-5 putative SAM-dependent methyltransferase YP_001742911.1 834154 D 439855 CDS YP_001742912.1 170680728 6143031 complement(835077..837302) 1 NC_010498.1 identified by match to protein family HMM PF00924; hypothetical protein 837302 6143031 EcSMS35_0831 Escherichia coli SMS-3-5 hypothetical protein YP_001742912.1 835077 R 439855 CDS YP_001742913.1 170682045 6144903 complement(837419..838141) 1 NC_010498.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 838141 glnQ 6144903 glnQ Escherichia coli SMS-3-5 glutamine ABC transporter ATP-binding protein YP_001742913.1 837419 R 439855 CDS YP_001742914.1 170683637 6146242 complement(838138..838797) 1 NC_010498.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 838797 glnP 6146242 glnP Escherichia coli SMS-3-5 glutamine ABC transporter permease YP_001742914.1 838138 R 439855 CDS YP_001742915.1 170680496 6142928 complement(838936..839682) 1 NC_010498.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 839682 glnH 6142928 glnH Escherichia coli SMS-3-5 glutamine ABC transporter periplasmic protein YP_001742915.1 838936 R 439855 CDS YP_001742916.1 170682007 6144665 complement(840086..840589) 1 NC_010498.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 840589 dps 6144665 dps Escherichia coli SMS-3-5 DNA starvation/stationary phase protection protein Dps YP_001742916.1 840086 R 439855 CDS YP_001742917.1 170684270 6146204 complement(840889..841776) 1 NC_010498.1 identified by match to protein family HMM PF00892; threonine and homoserine efflux system 841776 rhtA 6146204 rhtA Escherichia coli SMS-3-5 threonine and homoserine efflux system YP_001742917.1 840889 R 439855 CDS YP_001742918.1 170681552 6143572 842129..842644 1 NC_010498.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 842644 ompX 6143572 ompX Escherichia coli SMS-3-5 outer membrane protein X YP_001742918.1 842129 D 439855 CDS YP_001742919.1 170680896 6145737 complement(842693..844276) 1 NC_010498.1 identified by match to protein family HMM PF00884; sulfatase family protein 844276 6145737 EcSMS35_0839 Escherichia coli SMS-3-5 sulfatase family protein YP_001742919.1 842693 R 439855 CDS YP_001742920.1 170680283 6145075 complement(844548..844676) 1 NC_010498.1 hypothetical protein 844676 6145075 EcSMS35_0840 Escherichia coli SMS-3-5 hypothetical protein YP_001742920.1 844548 R 439855 CDS YP_001742921.1 170679643 6144450 844862..845329 1 NC_010498.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 845329 mntR 6144450 mntR Escherichia coli SMS-3-5 manganese transport regulator MntR YP_001742921.1 844862 D 439855 CDS YP_001742922.1 170683327 6143800 845326..846444 1 NC_010498.1 identified by match to protein family HMM PF03600; citrate transporter family protein 846444 6143800 EcSMS35_0842 Escherichia coli SMS-3-5 citrate transporter family protein YP_001742922.1 845326 D 439855 CDS YP_001742923.1 170683699 6142612 complement(846503..847423) 1 NC_010498.1 identified by match to protein family HMM PF03734; hypothetical protein 847423 ybiS 6142612 ybiS Escherichia coli SMS-3-5 hypothetical protein YP_001742923.1 846503 R 439855 CDS YP_001742924.1 170681928 6142991 847642..849234 1 NC_010498.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 849234 6142991 EcSMS35_0844 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001742924.1 847642 D 439855 CDS YP_001742925.1 170681843 6146124 849307..849426 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 849426 6146124 EcSMS35_0845 Escherichia coli SMS-3-5 hypothetical protein YP_001742925.1 849307 D 439855 CDS YP_001742926.1 170683552 6146036 complement(849475..850740) 1 NC_010498.1 identified by match to protein family HMM PF07350; hypothetical protein 850740 6146036 EcSMS35_0846 Escherichia coli SMS-3-5 hypothetical protein YP_001742926.1 849475 R 439855 CDS YP_001742927.1 170682885 6142842 complement(850892..851707) 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; sugar phosphatase SupH 851707 supH 6142842 supH Escherichia coli SMS-3-5 sugar phosphatase SupH YP_001742927.1 850892 R 439855 CDS YP_001742928.1 170680406 6147098 complement(851853..854285) 1 NC_010498.1 identified by similarity to SP:P75793; match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; formate C-acetyltransferase 3 854285 6147098 EcSMS35_0848 Escherichia coli SMS-3-5 formate C-acetyltransferase 3 YP_001742928.1 851853 R 439855 CDS YP_001742929.1 170683998 6144575 complement(854291..855190) 1 NC_010498.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; glycyl-radical activating family protein 855190 6144575 EcSMS35_0849 Escherichia coli SMS-3-5 glycyl-radical activating family protein YP_001742929.1 854291 R 439855 CDS YP_001742930.1 170681408 6143297 855321..855983 1 NC_010498.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 855983 fsaA 6143297 fsaA Escherichia coli SMS-3-5 fructose-6-phosphate aldolase YP_001742930.1 855321 D 439855 CDS YP_001742931.1 170680893 6145592 complement(856059..856808) 1 NC_010498.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 856808 moeB 6145592 moeB Escherichia coli SMS-3-5 molybdopterin biosynthesis protein MoeB YP_001742931.1 856059 R 439855 CDS YP_001742932.1 170681896 6145071 complement(856808..858043) 1 NC_010498.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 858043 moeA 6145071 moeA Escherichia coli SMS-3-5 molybdopterin biosynthesis protein MoeA YP_001742932.1 856808 R 439855 CDS YP_001742933.1 170681222 6146091 858247..859212 1 NC_010498.1 identified by match to protein family HMM PF01112; L-asparaginase 859212 6146091 EcSMS35_0853 Escherichia coli SMS-3-5 L-asparaginase YP_001742933.1 858247 D 439855 CDS YP_001742934.1 170680445 6145406 859199..861070 1 NC_010498.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 861070 gsiA 6145406 gsiA Escherichia coli SMS-3-5 glutathione transporter ATP-binding protein YP_001742934.1 859199 D 439855 CDS YP_001742935.1 170680264 6144614 861090..862628 1 NC_010498.1 identified by match to protein family HMM PF00496; glutathione ABC transporter periplasmic glutathione-binding protein GsiB 862628 gsiB 6144614 gsiB Escherichia coli SMS-3-5 glutathione ABC transporter periplasmic glutathione-binding protein GsiB YP_001742935.1 861090 D 439855 CDS YP_001742936.1 170681941 6144431 862646..863566 1 NC_010498.1 identified by match to protein family HMM PF00528; glutathione ABC transporter permease GsiC 863566 gsiC 6144431 gsiC Escherichia coli SMS-3-5 glutathione ABC transporter permease GsiC YP_001742936.1 862646 D 439855 CDS YP_001742937.1 170682461 6146137 863569..864480 1 NC_010498.1 identified by match to protein family HMM PF00528; glutathione ABC transporter permease GsiD 864480 gsiD 6146137 gsiD Escherichia coli SMS-3-5 glutathione ABC transporter permease GsiD YP_001742937.1 863569 D 439855 CDS YP_001742938.1 170681940 6146660 864657..867005 1 NC_010498.1 identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 867005 6146660 EcSMS35_0858 Escherichia coli SMS-3-5 cyclic diguanylate phosphodiesterase domain-containing protein YP_001742938.1 864657 D 439855 CDS YP_001742939.1 170682625 6146136 867115..868341 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 868341 6146136 EcSMS35_0859 Escherichia coli SMS-3-5 diguanylate cyclase YP_001742939.1 867115 D 439855 CDS YP_001742940.1 170683292 6146831 complement(868411..868740) 1 NC_010498.1 identified by match to protein family HMM PF01381; DNA-binding protein 868740 6146831 EcSMS35_0860 Escherichia coli SMS-3-5 DNA-binding protein YP_001742940.1 868411 R 439855 CDS YP_001742941.1 170683971 6147518 complement(868730..869116) 1 NC_010498.1 identified by match to protein family HMM PF06296; hypothetical protein 869116 6147518 EcSMS35_0861 Escherichia coli SMS-3-5 hypothetical protein YP_001742941.1 868730 R 439855 CDS YP_001742942.1 170679937 6143268 complement(869342..870667) 1 NC_010498.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 870667 rimO 6143268 rimO Escherichia coli SMS-3-5 ribosomal protein S12 methylthiotransferase YP_001742942.1 869342 R 439855 CDS YP_001742943.1 170679707 6144099 870880..871263 1 NC_010498.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 871263 bssR 6144099 bssR Escherichia coli SMS-3-5 biofilm formation regulatory protein BssR YP_001742943.1 870880 D 439855 CDS YP_001742944.1 170679987 6143865 871374..872489 1 NC_010498.1 identified by match to protein family HMM PF07995; glucose / sorbosone dehydrogenase protein 872489 6143865 EcSMS35_0865 Escherichia coli SMS-3-5 glucose / sorbosone dehydrogenase protein YP_001742944.1 871374 D 439855 CDS YP_001742945.1 170680459 6144149 complement(872486..873112) 1 NC_010498.1 identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase family protein 873112 6144149 EcSMS35_0864 Escherichia coli SMS-3-5 glutathione S-transferase family protein YP_001742945.1 872486 R 439855 CDS YP_001742946.1 170681795 6144628 873350..874561 1 NC_010498.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 874561 dacC 6144628 dacC Escherichia coli SMS-3-5 D-alanyl-D-alanine carboxypeptidase fraction C YP_001742946.1 873350 D 439855 CDS YP_001742947.1 170680830 6145988 complement(874608..875366) 1 NC_010498.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; DNA-binding transcriptional repressor DeoR 875366 deoR 6145988 deoR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor DeoR YP_001742947.1 874608 R 439855 CDS YP_001742948.1 170682184 6145007 complement(875424..876020) 1 NC_010498.1 ybjG; identified by similarity to SP:P75806; match to protein family HMM PF01569; undecaprenyl pyrophosphate phosphatase 876020 6145007 EcSMS35_0868 Escherichia coli SMS-3-5 undecaprenyl pyrophosphate phosphatase YP_001742948.1 875424 R 439855 CDS YP_001742949.1 170681504 6146383 876305..877537 1 NC_010498.1 identified by match to protein family HMM PF07690; multidrug translocase MdfA 877537 mdfA 6146383 mdfA Escherichia coli SMS-3-5 multidrug translocase MdfA YP_001742949.1 876305 D 439855 CDS YP_001742950.1 170682945 6145689 complement(877578..877856) 1 NC_010498.1 hypothetical protein 877856 6145689 EcSMS35_0870 Escherichia coli SMS-3-5 hypothetical protein YP_001742950.1 877578 R 439855 CDS YP_001742951.1 170682272 6147160 complement(877948..878763) 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YbjI 878763 ybjI 6147160 ybjI Escherichia coli SMS-3-5 phosphatase YbjI YP_001742951.1 877948 R 439855 CDS YP_001742952.1 170679939 6146471 complement(878763..879971) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 879971 6146471 EcSMS35_0872 Escherichia coli SMS-3-5 major facilitator transporter YP_001742952.1 878763 R 439855 CDS YP_001742953.1 170684289 6144101 880055..880591 1 NC_010498.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 880591 6144101 EcSMS35_0873 Escherichia coli SMS-3-5 TetR family transcriptional regulator YP_001742953.1 880055 D 439855 CDS YP_001742954.1 170683131 6143591 complement(880766..882451) 1 NC_010498.1 identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625; hypothetical protein 882451 6143591 EcSMS35_0874 Escherichia coli SMS-3-5 hypothetical protein YP_001742954.1 880766 R 439855 CDS YP_001742955.1 170682757 6147350 882721..883098 1 NC_010498.1 hypothetical protein 883098 6147350 EcSMS35_0875 Escherichia coli SMS-3-5 hypothetical protein YP_001742955.1 882721 D 439855 CDS YP_001742956.1 170680724 6146966 complement(883128..883385) 1 NC_010498.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 883385 grxA 6146966 grxA Escherichia coli SMS-3-5 glutaredoxin 1 YP_001742956.1 883128 R 439855 CDS YP_001742957.1 170680044 6144899 883545..883832 1 NC_010498.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 883832 6144899 EcSMS35_0877 Escherichia coli SMS-3-5 hypothetical protein YP_001742957.1 883545 D 439855 CDS YP_001742958.1 170681760 6144207 883816..884538 1 NC_010498.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 884538 nfsA 6144207 nfsA Escherichia coli SMS-3-5 nitroreductase A YP_001742958.1 883816 D 439855 CDS YP_001742959.1 170681044 6145951 884599..885501 1 NC_010498.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 885501 rimK 6145951 rimK Escherichia coli SMS-3-5 ribosomal protein S6 modification protein YP_001742959.1 884599 D 439855 CDS YP_001742960.1 170682777 6145225 885589..886065 1 NC_010498.1 TPR repeat-containing protein 886065 6145225 EcSMS35_0880 Escherichia coli SMS-3-5 TPR repeat-containing protein YP_001742960.1 885589 D 439855 CDS YP_001742961.1 170682249 6146986 886022..886144 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 886144 6146986 EcSMS35_0881 Escherichia coli SMS-3-5 hypothetical protein YP_001742961.1 886022 D 439855 CDS YP_001742962.1 170682561 6146448 886416..887528 1 NC_010498.1 identified by match to protein family HMM PF01547; putrescine transporter subunit: periplasmic-binding component of ABC superfamily 887528 potF 6146448 potF Escherichia coli SMS-3-5 putrescine transporter subunit: periplasmic-binding component of ABC superfamily YP_001742962.1 886416 D 439855 CDS YP_001742963.1 170682026 6146764 887623..888756 1 NC_010498.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 888756 potG 6146764 potG Escherichia coli SMS-3-5 putrescine transporter ATP-binding subunit YP_001742963.1 887623 D 439855 CDS YP_001742964.1 170684139 6146223 888766..889719 1 NC_010498.1 identified by match to protein family HMM PF00528; putrescine transporter subunit: membrane component of ABC superfamily 889719 potH 6146223 potH Escherichia coli SMS-3-5 putrescine transporter subunit: membrane component of ABC superfamily YP_001742964.1 888766 D 439855 CDS YP_001742965.1 170682279 6143439 889716..890561 1 NC_010498.1 identified by match to protein family HMM PF00528; putrescine transporter subunit: membrane component of ABC superfamily 890561 potI 6143439 potI Escherichia coli SMS-3-5 putrescine transporter subunit: membrane component of ABC superfamily YP_001742965.1 889716 D 439855 CDS YP_001742966.1 170680971 6146478 890621..891109 1 NC_010498.1 hypothetical protein 891109 6146478 EcSMS35_0886 Escherichia coli SMS-3-5 hypothetical protein YP_001742966.1 890621 D 439855 CDS YP_001742967.1 170681470 6145152 891150..892277 1 NC_010498.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 892277 rumB 6145152 rumB Escherichia coli SMS-3-5 23S rRNA methyluridine methyltransferase YP_001742967.1 891150 D 439855 CDS YP_001742968.1 170681491 6145655 complement(892306..893037) 1 NC_010498.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; arginine ABC transporter periplasmic arginine-binding protein ArtJ 893037 artJ 6145655 artJ Escherichia coli SMS-3-5 arginine ABC transporter periplasmic arginine-binding protein ArtJ YP_001742968.1 892306 R 439855 CDS YP_001742969.1 170679691 6145676 complement(893263..893931) 1 NC_010498.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 893931 artM 6145676 artM Escherichia coli SMS-3-5 arginine transporter permease subunit ArtM YP_001742969.1 893263 R 439855 CDS YP_001742970.1 170680675 6143849 complement(893931..894647) 1 NC_010498.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 894647 artQ 6143849 artQ Escherichia coli SMS-3-5 arginine transporter permease subunit ArtQ YP_001742970.1 893931 R 439855 CDS YP_001742971.1 170683620 6144850 complement(894654..895385) 1 NC_010498.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; arginine ABC transporter periplasmic arginine-binding protein ArtI 895385 artI 6144850 artI Escherichia coli SMS-3-5 arginine ABC transporter periplasmic arginine-binding protein ArtI YP_001742971.1 894654 R 439855 CDS YP_001742972.1 170682260 6142910 complement(895403..896131) 1 NC_010498.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 896131 artP 6142910 artP Escherichia coli SMS-3-5 arginine transporter ATP-binding subunit YP_001742972.1 895403 R 439855 CDS YP_001742973.1 170682941 6146459 complement(896349..896864) 1 NC_010498.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; putative lipoprotein 896864 6146459 EcSMS35_0893 Escherichia coli SMS-3-5 putative lipoprotein YP_001742973.1 896349 R 439855 CDS YP_001742974.1 170683845 6147155 897479..899281 1 NC_010498.1 hypothetical protein 899281 6147155 EcSMS35_0894 Escherichia coli SMS-3-5 hypothetical protein YP_001742974.1 897479 D 439855 CDS YP_001742975.1 170683177 6143139 899492..899815 1 NC_010498.1 identified by match to protein family HMM PF01906; hypothetical protein 899815 6143139 EcSMS35_0895 Escherichia coli SMS-3-5 hypothetical protein YP_001742975.1 899492 D 439855 CDS YP_001742976.1 170682080 6147397 899812..900642 1 NC_010498.1 identified by similarity to SP:P75820; match to protein family HMM PF01510; N-acetylmuramoyl-L-alanine amidase AmiD 900642 amiD 6147397 amiD Escherichia coli SMS-3-5 N-acetylmuramoyl-L-alanine amidase AmiD YP_001742976.1 899812 D 439855 CDS YP_001742977.1 170682810 6146277 complement(900639..901688) 1 NC_010498.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; NAD-dependent epimerase/dehydratase family protein 901688 6146277 EcSMS35_0896 Escherichia coli SMS-3-5 NAD-dependent epimerase/dehydratase family protein YP_001742977.1 900639 R 439855 CDS YP_001742978.1 170681016 6147021 complement(901751..903181) 1 NC_010498.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; NAD dependent epimerase/dehydratase family protein 903181 6147021 EcSMS35_0898 Escherichia coli SMS-3-5 NAD dependent epimerase/dehydratase family protein YP_001742978.1 901751 R 439855 CDS YP_001742979.1 170681482 6145197 complement(903192..904193) 1 NC_010498.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 904193 ltaE 6145197 ltaE Escherichia coli SMS-3-5 L-threonine aldolase YP_001742979.1 903192 R 439855 CDS YP_001742980.1 170679672 6145667 complement(904230..905948) 1 NC_010498.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 905948 poxB 6145667 poxB Escherichia coli SMS-3-5 pyruvate dehydrogenase YP_001742980.1 904230 R 439855 CDS YP_001742981.1 170683685 6143830 complement(906081..907049) 1 NC_010498.1 identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; HCP oxidoreductase, NADH-dependent 907049 hcr 6143830 hcr Escherichia coli SMS-3-5 HCP oxidoreductase, NADH-dependent YP_001742981.1 906081 R 439855 CDS YP_001742982.1 170683671 6142977 complement(907061..908713) 1 NC_010498.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 908713 hcp 6142977 hcp Escherichia coli SMS-3-5 hydroxylamine reductase YP_001742982.1 907061 R 439855 CDS YP_001742983.1 170684217 6142963 complement(908857..909756) 1 NC_010498.1 identified by match to protein family HMM PF03956; hypothetical protein 909756 6142963 EcSMS35_0903 Escherichia coli SMS-3-5 hypothetical protein YP_001742983.1 908857 R 439855 CDS YP_001742984.1 170681747 6143518 910096..911121 1 NC_010498.1 identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS110 family transposase 911121 6143518 EcSMS35_0904 Escherichia coli SMS-3-5 IS110 family transposase YP_001742984.1 910096 D 439855 CDS YP_001742985.1 170681074 6145937 911930..913366 1 NC_010498.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 913366 6145937 EcSMS35_0905 Escherichia coli SMS-3-5 multidrug resistance outer membrane protein MdtQ YP_001742985.1 911930 D 439855 CDS YP_001742986.1 170680771 6145256 913419..914180 1 NC_010498.1 identified by match to protein family HMM PF00106; acetoin dehydrogenase 914180 6145256 EcSMS35_0906 Escherichia coli SMS-3-5 acetoin dehydrogenase YP_001742986.1 913419 D 439855 CDS YP_001742987.1 170683385 6144946 914190..914309 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 914309 6144946 EcSMS35_0908 Escherichia coli SMS-3-5 hypothetical protein YP_001742987.1 914190 D 439855 CDS YP_001742988.1 170682767 6142671 complement(914300..914878) 1 NC_010498.1 identified by match to protein family HMM PF09335; hypothetical protein 914878 6142671 EcSMS35_0907 Escherichia coli SMS-3-5 hypothetical protein YP_001742988.1 914300 R 439855 CDS YP_001742989.1 170680224 6146976 915048..915635 1 NC_010498.1 identified by match to protein family HMM PF06930; hypothetical protein 915635 6146976 EcSMS35_0909 Escherichia coli SMS-3-5 hypothetical protein YP_001742989.1 915048 D 439855 CDS YP_001742990.1 170679983 6144390 915800..916741 1 NC_010498.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 916741 pbpG 6144390 pbpG Escherichia coli SMS-3-5 D-alanyl-D-alanine endopeptidase YP_001742990.1 915800 D 439855 CDS YP_001742991.1 170681665 6144145 complement(916780..918495) 1 NC_010498.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 918495 dld 6144145 dld Escherichia coli SMS-3-5 D-lactate dehydrogenase YP_001742991.1 916780 R 439855 CDS YP_001742992.1 170681058 6145851 918691..920988 1 NC_010498.1 identified by match to protein family HMM PF00933; match to protein family HMM PF01915; beta-glucosidase, periplasmic 920988 bglX 6145851 bglX Escherichia coli SMS-3-5 beta-glucosidase, periplasmic YP_001742992.1 918691 D 439855 CDS YP_001742993.1 170683010 6145239 921240..922157 1 NC_010498.1 identified by match to protein family HMM PF04069; quaternary amine ABC transporter periplasmic substrate-binding protein 922157 6145239 EcSMS35_0913 Escherichia coli SMS-3-5 quaternary amine ABC transporter periplasmic substrate-binding protein YP_001742993.1 921240 D 439855 CDS YP_001742994.1 170682890 6147226 922164..923321 1 NC_010498.1 identified by match to protein family HMM PF00528; quaternary amine ABC transporter permease 923321 6147226 EcSMS35_0914 Escherichia coli SMS-3-5 quaternary amine ABC transporter permease YP_001742994.1 922164 D 439855 CDS YP_001742995.1 170684202 6147103 923314..924240 1 NC_010498.1 identified by match to protein family HMM PF00005; quaternary amine ABC transporter ATP-binding protein 924240 6147103 EcSMS35_0915 Escherichia coli SMS-3-5 quaternary amine ABC transporter ATP-binding protein YP_001742995.1 923314 D 439855 CDS YP_001742996.1 170680189 6143503 924245..924976 1 NC_010498.1 identified by match to protein family HMM PF00528; quaternary amine ABC transporter permease 924976 6143503 EcSMS35_0916 Escherichia coli SMS-3-5 quaternary amine ABC transporter permease YP_001742996.1 924245 D 439855 CDS YP_001742997.1 170680991 6144355 complement(925124..925855) 1 NC_010498.1 identified by similarity to SP:P33358; match to protein family HMM PF00376; transcriptional regulator MlrA 925855 6144355 EcSMS35_0917 Escherichia coli SMS-3-5 transcriptional regulator MlrA YP_001742997.1 925124 R 439855 CDS YP_001742998.1 170681525 6145172 926077..927762 1 NC_010498.1 identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694; sensor histidine kinase 927762 6145172 EcSMS35_0918 Escherichia coli SMS-3-5 sensor histidine kinase YP_001742998.1 926077 D 439855 CDS YP_001742999.1 170681501 6145710 927759..928478 1 NC_010498.1 unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 928478 6145710 EcSMS35_0919 Escherichia coli SMS-3-5 putative two-component response-regulatory protein YehT YP_001742999.1 927759 D 439855 CDS YP_001743000.1 170682350 6145686 928525..928995 1 NC_010498.1 identified by match to protein family HMM PF07308; hypothetical protein 928995 6145686 EcSMS35_0920 Escherichia coli SMS-3-5 hypothetical protein YP_001743000.1 928525 D 439855 CDS YP_001743001.1 170682891 6146549 complement(929036..929497) 1 NC_010498.1 identified by match to protein family HMM PF06998; putative lipoprotein 929497 6146549 EcSMS35_0921 Escherichia coli SMS-3-5 putative lipoprotein YP_001743001.1 929036 R 439855 CDS YP_001743002.1 170683564 6147104 complement(929622..931622) 1 NC_010498.1 identified by match to protein family HMM PF04434; hypothetical protein 931622 6147104 EcSMS35_0922 Escherichia coli SMS-3-5 hypothetical protein YP_001743002.1 929622 R 439855 CDS YP_001743003.1 170683571 6142854 complement(931619..932755) 1 NC_010498.1 identified by match to protein family HMM PF00092; match to protein family HMM PF05762; von Willebrand factor type A domain-containing protein 932755 6142854 EcSMS35_0923 Escherichia coli SMS-3-5 von Willebrand factor type A domain-containing protein YP_001743003.1 931619 R 439855 CDS YP_001743004.1 170684260 6142862 complement(932748..935027) 1 NC_010498.1 hypothetical protein 935027 6142862 EcSMS35_0924 Escherichia coli SMS-3-5 hypothetical protein YP_001743004.1 932748 R 439855 CDS YP_001743005.1 170683960 6143562 complement(935038..936126) 1 NC_010498.1 identified by match to protein family HMM PF07728; AAA family ATPase 936126 6143562 EcSMS35_0925 Escherichia coli SMS-3-5 AAA family ATPase YP_001743005.1 935038 R 439855 CDS YP_001743006.1 170679615 6143257 complement(936702..937022) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 937022 6143257 EcSMS35_0926 Escherichia coli SMS-3-5 hypothetical protein YP_001743006.1 936702 R 439855 CDS YP_001743007.1 170680560 6143772 complement(937083..940745) 1 NC_010498.1 molybdate metabolism regulator MolR-like protein 940745 6143772 EcSMS35_0927 Escherichia coli SMS-3-5 molybdate metabolism regulator MolR-like protein YP_001743007.1 937083 R 439855 CDS YP_001743008.1 170680946 6144730 complement(940755..944543) 1 NC_010498.1 identified by similarity to SP:P33345; match to protein family HMM PF05406; molybdate metabolism regulator MolR 944543 molR 6144730 molR Escherichia coli SMS-3-5 molybdate metabolism regulator MolR YP_001743008.1 940755 R 439855 CDS YP_001743009.1 170681859 6145127 complement(944684..946717) 1 NC_010498.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 946717 metG 6145127 metG Escherichia coli SMS-3-5 methionyl-tRNA synthetase YP_001743009.1 944684 R 439855 CDS YP_001743010.1 170682232 6146053 946849..947958 1 NC_010498.1 putative ATPase 947958 6146053 EcSMS35_0930 Escherichia coli SMS-3-5 putative ATPase YP_001743010.1 946849 D 439855 CDS YP_001743011.1 170681954 6146431 948221..948502 1 NC_010498.1 identified by similarity to GB:AAP17529.1; hypothetical protein 948502 6146431 EcSMS35_0931 Escherichia coli SMS-3-5 hypothetical protein YP_001743011.1 948221 D 439855 CDS YP_001743012.1 170682616 6146150 948798..949340 1 NC_010498.1 identified by match to protein family HMM PF00419; fimbrial protein 949340 6146150 EcSMS35_0932 Escherichia coli SMS-3-5 fimbrial protein YP_001743012.1 948798 D 439855 CDS YP_001743013.1 170684280 6142802 950111..952591 1 NC_010498.1 yehB; identified by match to protein family HMM PF00577; fimbrial usher protein 952591 6142802 EcSMS35_0934 Escherichia coli SMS-3-5 fimbrial usher protein YP_001743013.1 950111 D 439855 CDS YP_001743014.1 170679988 6143582 952607..953641 1 NC_010498.1 hypothetical protein 953641 6143582 EcSMS35_0935 Escherichia coli SMS-3-5 hypothetical protein YP_001743014.1 952607 D 439855 CDS YP_001743015.1 170679655 6144150 complement(953723..954061) 1 NC_010498.1 hypothetical protein 954061 6144150 EcSMS35_0936 Escherichia coli SMS-3-5 hypothetical protein YP_001743015.1 953723 R 439855 CDS YP_001743016.1 170681275 6143812 complement(954280..955104) 1 NC_010498.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 955104 rcnA 6143812 rcnA Escherichia coli SMS-3-5 nickel/cobalt efflux protein RcnA YP_001743016.1 954280 R 439855 CDS YP_001743017.1 170681417 6145459 955225..955497 1 NC_010498.1 identified by match to protein family HMM PF02583; transcriptional repressor RcnR 955497 rcnR 6145459 rcnR Escherichia coli SMS-3-5 transcriptional repressor RcnR YP_001743017.1 955225 D 439855 CDS YP_001743018.1 170682065 6145601 955827..957047 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 957047 6145601 EcSMS35_0939 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001743018.1 955827 D 439855 CDS YP_001743019.1 170682889 6146262 957044..957898 1 NC_010498.1 identified by similarity to GB:CAG74537.1; hypothetical protein 957898 6146262 EcSMS35_0940 Escherichia coli SMS-3-5 hypothetical protein YP_001743019.1 957044 D 439855 CDS YP_001743020.1 170683381 6147102 958002..958226 1 NC_010498.1 identified by match to protein family HMM PF05930; AlpA family transcriptional regulator 958226 6147102 EcSMS35_0941 Escherichia coli SMS-3-5 AlpA family transcriptional regulator YP_001743020.1 958002 D 439855 CDS YP_001743021.1 170679986 6142667 958237..959055 1 NC_010498.1 identified by similarity to GB:AAZ87612.1; hypothetical protein 959055 6142667 EcSMS35_0942 Escherichia coli SMS-3-5 hypothetical protein YP_001743021.1 958237 D 439855 CDS YP_001743022.1 170680725 6144148 959075..959278 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 959278 6144148 EcSMS35_0943 Escherichia coli SMS-3-5 hypothetical protein YP_001743022.1 959075 D 439855 CDS YP_001743023.1 170681192 6144900 959271..959591 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 959591 6144900 EcSMS35_0944 Escherichia coli SMS-3-5 hypothetical protein YP_001743023.1 959271 D 439855 CDS YP_001743024.1 170681857 6145376 959598..959897 1 NC_010498.1 identified by similarity to GB:AAZ87613.1; hypothetical protein 959897 6145376 EcSMS35_0945 Escherichia coli SMS-3-5 hypothetical protein YP_001743024.1 959598 D 439855 CDS YP_001743025.1 170680147 6146051 959894..961711 1 NC_010498.1 identified by match to protein family HMM PF03288; match to protein family HMM PF08706; D5 family nucleoside triphosphatase 961711 6146051 EcSMS35_0946 Escherichia coli SMS-3-5 D5 family nucleoside triphosphatase YP_001743025.1 959894 D 439855 CDS YP_001743026.1 170683188 6144313 961999..962244 1 NC_010498.1 identified by similarity to GB:AAZ87617.1; hypothetical protein 962244 6144313 EcSMS35_0947 Escherichia coli SMS-3-5 hypothetical protein YP_001743026.1 961999 D 439855 CDS YP_001743027.1 170683723 6147408 962241..962666 1 NC_010498.1 identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621; single-strand binding protein family 962666 6147408 EcSMS35_0948 Escherichia coli SMS-3-5 single-strand binding protein family YP_001743027.1 962241 D 439855 CDS YP_001743028.1 170682171 6143015 962689..962931 1 NC_010498.1 identified by similarity to GB:ABF03362.1; hypothetical protein 962931 6143015 EcSMS35_0949 Escherichia coli SMS-3-5 hypothetical protein YP_001743028.1 962689 D 439855 CDS YP_001743029.1 170682671 6146370 complement(962967..963473) 1 NC_010498.1 hypothetical protein 963473 6146370 EcSMS35_0950 Escherichia coli SMS-3-5 hypothetical protein YP_001743029.1 962967 R 439855 CDS YP_001743030.1 170681140 6146879 963760..964929 1 NC_010498.1 identified by match to protein family HMM PF05065; match to protein family HMM TIGR01554; HK97 family phage major capsid protein 964929 6146879 EcSMS35_0951 Escherichia coli SMS-3-5 HK97 family phage major capsid protein YP_001743030.1 963760 D 439855 CDS YP_001743031.1 170681758 6145323 964984..965544 1 NC_010498.1 identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543; HK97 family phage prohead protease 965544 6145323 EcSMS35_0952 Escherichia coli SMS-3-5 HK97 family phage prohead protease YP_001743031.1 964984 D 439855 CDS YP_001743032.1 170684127 6145949 965546..966760 1 NC_010498.1 identified by match to protein family HMM PF04860; match to protein family HMM TIGR01537; HK97 family phage portal protein 966760 6145949 EcSMS35_0953 Escherichia coli SMS-3-5 HK97 family phage portal protein YP_001743032.1 965546 D 439855 CDS YP_001743033.1 170679967 6143427 966753..967055 1 NC_010498.1 identified by match to protein family HMM PF05135; match to protein family HMM TIGR01560; DNA packaging, phage QLRG family protein 967055 6143427 EcSMS35_0954 Escherichia coli SMS-3-5 DNA packaging, phage QLRG family protein YP_001743033.1 966753 D 439855 CDS YP_001743034.1 170680539 6144129 967055..967495 1 NC_010498.1 identified by match to protein family HMM PF01844; HNH endonuclease family protein 967495 6144129 EcSMS35_0955 Escherichia coli SMS-3-5 HNH endonuclease family protein YP_001743034.1 967055 D 439855 CDS YP_001743035.1 170680329 6144709 967757..968140 1 NC_010498.1 identified by match to protein family HMM PF05119; match to protein family HMM TIGR01558; P27 family phage terminase small subunit 968140 6144709 EcSMS35_0956 Escherichia coli SMS-3-5 P27 family phage terminase small subunit YP_001743035.1 967757 D 439855 CDS YP_001743036.1 170683362 6144497 968124..969785 1 NC_010498.1 identified by match to protein family HMM PF03354; putative phage terminase, large subunit 969785 6144497 EcSMS35_0957 Escherichia coli SMS-3-5 putative phage terminase, large subunit YP_001743036.1 968124 D 439855 CDS YP_001743037.1 170683728 6142648 969791..970072 1 NC_010498.1 identified by similarity to RF:NP_836846.1; hypothetical protein 970072 6142648 EcSMS35_0958 Escherichia coli SMS-3-5 hypothetical protein YP_001743037.1 969791 D 439855 CDS YP_001743038.1 170682010 6143020 complement(970562..970723) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 970723 6143020 EcSMS35_0959 Escherichia coli SMS-3-5 hypothetical protein YP_001743038.1 970562 R 439855 CDS YP_001743039.1 170682995 6146207 970862..971650 1 NC_010498.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 971650 thiM 6146207 thiM Escherichia coli SMS-3-5 hydroxyethylthiazole kinase YP_001743039.1 970862 D 439855 CDS YP_001743040.1 170681061 6147211 971647..972447 1 NC_010498.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 972447 thiD 6147211 thiD Escherichia coli SMS-3-5 phosphomethylpyrimidine kinase YP_001743040.1 971647 D 439855 CDS YP_001743041.1 170681659 6145243 972512..973330 1 NC_010498.1 identified by match to protein family HMM PF01183; glycosyl hydrolase family protein 973330 6145243 EcSMS35_0962 Escherichia coli SMS-3-5 glycosyl hydrolase family protein YP_001743041.1 972512 D 439855 CDS YP_001743042.1 170681641 6145845 973382..974128 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM PF08279; GntR family transcriptional regulator 974128 6145845 EcSMS35_0964 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001743042.1 973382 D 439855 CDS YP_001743043.1 170683756 6145827 complement(974102..975067) 1 NC_010498.1 identified by match to protein family HMM PF00294; PfkB family kinase 975067 6145827 EcSMS35_0963 Escherichia coli SMS-3-5 PfkB family kinase YP_001743043.1 974102 R 439855 CDS YP_001743044.1 170681153 6143048 complement(975064..976068) 1 NC_010498.1 identified by match to protein family HMM PF03747; ADP-ribosylglycohydrolase family protein 976068 6143048 EcSMS35_0965 Escherichia coli SMS-3-5 ADP-ribosylglycohydrolase family protein YP_001743044.1 975064 R 439855 CDS YP_001743045.1 170680614 6145336 complement(976065..977342) 1 NC_010498.1 identified by match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; nucleoside transporter 977342 yegT 6145336 yegT Escherichia coli SMS-3-5 nucleoside transporter YP_001743045.1 976065 R 439855 CDS YP_001743046.1 170680106 6144788 977599..978651 1 NC_010498.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 978651 fbaB 6144788 fbaB Escherichia coli SMS-3-5 fructose-bisphosphate aldolase YP_001743046.1 977599 D 439855 CDS YP_001743047.1 170681634 6144270 978880..979734 1 NC_010498.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 979734 gatY 6144270 gatY Escherichia coli SMS-3-5 tagatose-bisphosphate aldolase YP_001743047.1 978880 D 439855 CDS YP_001743048.1 170681136 6145820 979763..981025 1 NC_010498.1 identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810; putative tagatose-6-phosphate kinase 981025 6145820 EcSMS35_0969 Escherichia coli SMS-3-5 putative tagatose-6-phosphate kinase YP_001743048.1 979763 D 439855 CDS YP_001743049.1 170680637 6145319 981035..981487 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 981487 gatA 6145319 gatA Escherichia coli SMS-3-5 PTS system galactitol-specific transporter subunit IIA YP_001743049.1 981035 D 439855 CDS YP_001743050.1 170680100 6144812 981518..981802 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 981802 gatB 6144812 gatB Escherichia coli SMS-3-5 PTS system galactitol-specific transporter subunit IIB YP_001743050.1 981518 D 439855 CDS YP_001743051.1 170683704 6144264 981806..983161 1 NC_010498.1 identified by match to protein family HMM PF03611; match to protein family HMM TIGR00827; PTS system, galactitol-specific IIC component 983161 gatC 6144264 gatC Escherichia coli SMS-3-5 PTS system, galactitol-specific IIC component YP_001743051.1 981806 D 439855 CDS YP_001743052.1 170680364 6142996 983209..984249 1 NC_010498.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 984249 gatD 6142996 gatD Escherichia coli SMS-3-5 galactitol-1-phosphate dehydrogenase YP_001743052.1 983209 D 439855 CDS YP_001743053.1 170682006 6144532 984349..985128 1 NC_010498.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; galactitol utilization operon repressor 985128 gatR 6144532 gatR Escherichia coli SMS-3-5 galactitol utilization operon repressor YP_001743053.1 984349 D 439855 CDS YP_001743054.1 170683733 6146203 complement(985210..986109) 1 NC_010498.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 986109 6146203 EcSMS35_0975 Escherichia coli SMS-3-5 lipid kinase YP_001743054.1 985210 R 439855 CDS YP_001743055.1 170681865 6143025 986564..986839 1 NC_010498.1 hypothetical protein 986839 6143025 EcSMS35_0976 Escherichia coli SMS-3-5 hypothetical protein YP_001743055.1 986564 D 439855 CDS YP_001743056.1 170681214 6146059 complement(987169..988530) 1 NC_010498.1 identified by match to protein family HMM PF01136; U32 family peptidase 988530 6146059 EcSMS35_0977 Escherichia coli SMS-3-5 U32 family peptidase YP_001743056.1 987169 R 439855 CDS YP_001743057.1 170682935 6145398 complement(988633..988929) 1 NC_010498.1 identified by match to protein family HMM PF05016; RelE/ParE family plasmid stabilization system protein 988929 6145398 EcSMS35_0978 Escherichia coli SMS-3-5 RelE/ParE family plasmid stabilization system protein YP_001743057.1 988633 R 439855 CDS YP_001743058.1 170682278 6147149 complement(988931..989182) 1 NC_010498.1 identified by match to protein family HMM PF01402; match to protein family HMM PF03693; match to protein family HMM TIGR02606; CC2985 family addiction module antidote protein 989182 6147149 EcSMS35_0979 Escherichia coli SMS-3-5 CC2985 family addiction module antidote protein YP_001743058.1 988931 R 439855 CDS YP_001743059.1 170680967 6146477 complement(989436..989768) 1 NC_010498.1 identified by match to protein family HMM PF07411; hypothetical protein 989768 6146477 EcSMS35_0980 Escherichia coli SMS-3-5 hypothetical protein YP_001743059.1 989436 R 439855 CDS YP_001743060.1 170680336 6145148 complement(989948..990670) 1 NC_010498.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 990670 baeR 6145148 baeR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator BaeR YP_001743060.1 989948 R 439855 CDS YP_001743061.1 170680059 6144504 complement(990667..992070) 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; signal transduction histidine-protein kinase BaeS 992070 baeS 6144504 baeS Escherichia coli SMS-3-5 signal transduction histidine-protein kinase BaeS YP_001743061.1 990667 R 439855 CDS YP_001743062.1 170682817 6144223 complement(992067..993482) 1 NC_010498.1 identified by match to protein family HMM PF07690; multidrug efflux system protein MdtE 993482 mdtD 6144223 mdtD Escherichia coli SMS-3-5 multidrug efflux system protein MdtE YP_001743062.1 992067 R 439855 CDS YP_001743063.1 170680004 6147028 complement(993483..996560) 1 NC_010498.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 996560 mdtC 6147028 mdtC Escherichia coli SMS-3-5 multidrug efflux system subunit MdtC YP_001743063.1 993483 R 439855 CDS YP_001743064.1 170680654 6144167 complement(996561..999683) 1 NC_010498.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 999683 mdtB 6144167 mdtB Escherichia coli SMS-3-5 multidrug efflux system subunit MdtB YP_001743064.1 996561 R 439855 CDS YP_001743065.1 170683959 6144829 complement(999683..1000930) 1 NC_010498.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 1000930 mdtA 6144829 mdtA Escherichia coli SMS-3-5 multidrug efflux system subunit MdtA YP_001743065.1 999683 R 439855 CDS YP_001743066.1 170679715 6143256 1001819..1002478 1 NC_010498.1 identified by match to protein family HMM PF00092; von Willebrand factor type A domain-containing protein 1002478 6143256 EcSMS35_0987 Escherichia coli SMS-3-5 von Willebrand factor type A domain-containing protein YP_001743066.1 1001819 D 439855 CDS YP_001743067.1 170682031 6143873 1002556..1003236 1 NC_010498.1 hypothetical protein 1003236 6143873 EcSMS35_0988 Escherichia coli SMS-3-5 hypothetical protein YP_001743067.1 1002556 D 439855 CDS YP_001743068.1 170682554 6146228 complement(1003301..1003822) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1003822 6146228 EcSMS35_0989 Escherichia coli SMS-3-5 hypothetical protein YP_001743068.1 1003301 R 439855 CDS YP_001743069.1 170681285 6146757 1003964..1005910 1 NC_010498.1 hypothetical protein 1005910 6146757 EcSMS35_0990 Escherichia coli SMS-3-5 hypothetical protein YP_001743069.1 1003964 D 439855 CDS YP_001743070.1 170681799 6145469 complement(1005923..1007275) 1 NC_010498.1 putative chaperone 1007275 6145469 EcSMS35_0991 Escherichia coli SMS-3-5 putative chaperone YP_001743070.1 1005923 R 439855 CDS YP_001743071.1 170682302 6145992 1007409..1008257 1 NC_010498.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 1008257 alkA 6145992 alkA Escherichia coli SMS-3-5 3-methyl-adenine DNA glycosylase II YP_001743071.1 1007409 D 439855 CDS YP_001743072.1 170682376 6146501 complement(1008367..1011684) 1 NC_010498.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 1011684 6146501 EcSMS35_0993 Escherichia coli SMS-3-5 putative sensor protein YP_001743072.1 1008367 R 439855 CDS YP_001743073.1 170680056 6146575 1012002..1012643 1 NC_010498.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1012643 udk 6146575 udk Escherichia coli SMS-3-5 uridine kinase YP_001743073.1 1012002 D 439855 CDS YP_001743074.1 170684104 6144220 1012735..1013316 1 NC_010498.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1013316 dcd 6144220 dcd Escherichia coli SMS-3-5 deoxycytidine triphosphate deaminase YP_001743074.1 1012735 D 439855 CDS YP_001743075.1 170681043 6143404 1013338..1015191 1 NC_010498.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 1015191 asmA 6143404 asmA Escherichia coli SMS-3-5 putative assembly protein YP_001743075.1 1013338 D 439855 CDS YP_001743076.1 170680529 6145224 complement(1015243..1015533) 1 NC_010498.1 identified by match to protein family HMM PF01381; putative DNA-binding protein 1015533 6145224 EcSMS35_0997 Escherichia coli SMS-3-5 putative DNA-binding protein YP_001743076.1 1015243 R 439855 CDS YP_001743077.1 170682735 6144699 complement(1015523..1015744) 1 NC_010498.1 identified by match to protein family HMM PF05973; hypothetical protein 1015744 6144699 EcSMS35_0998 Escherichia coli SMS-3-5 hypothetical protein YP_001743077.1 1015523 R 439855 CDS YP_001743078.1 170682196 6146943 complement(1016082..1017665) 1 NC_010498.1 identified by match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741; TerC family/CBS/transporter associated domain-containing protein 1017665 6146943 EcSMS35_0999 Escherichia coli SMS-3-5 TerC family/CBS/transporter associated domain-containing protein YP_001743078.1 1016082 R 439855 CDS YP_001743079.1 170683770 6146395 1018324..1019463 1 NC_010498.1 identified by match to protein family HMM PF02563; polysaccharide biosynthesis/export protein 1019463 6146395 EcSMS35_1000 Escherichia coli SMS-3-5 polysaccharide biosynthesis/export protein YP_001743079.1 1018324 D 439855 CDS YP_001743080.1 170683201 6143062 1019469..1019912 1 NC_010498.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 1019912 wzb 6143062 wzb Escherichia coli SMS-3-5 tyrosine phosphatase YP_001743080.1 1019469 D 439855 CDS YP_001743081.1 170681107 6147421 1019915..1022077 1 NC_010498.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 1022077 wzc 6147421 wzc Escherichia coli SMS-3-5 tyrosine kinase YP_001743081.1 1019915 D 439855 CDS YP_001743082.1 170681630 6145290 1022169..1023008 1 NC_010498.1 identified by match to protein family HMM PF00535; putative glycosyl transferase 1023008 wcaA 6145290 wcaA Escherichia coli SMS-3-5 putative glycosyl transferase YP_001743082.1 1022169 D 439855 CDS YP_001743083.1 170682182 6145815 1023011..1023499 1 NC_010498.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 1023499 6145815 EcSMS35_1004 Escherichia coli SMS-3-5 putative colanic acid biosynthesis acetyltransferase WcaB YP_001743083.1 1023011 D 439855 CDS YP_001743084.1 170682720 6146381 1023496..1024713 1 NC_010498.1 putative glycosyl transferase 1024713 wcaC 6146381 wcaC Escherichia coli SMS-3-5 putative glycosyl transferase YP_001743084.1 1023496 D 439855 CDS YP_001743085.1 170683218 6146928 1024688..1025905 1 NC_010498.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 1025905 wcaD 6146928 wcaD Escherichia coli SMS-3-5 putative colanic acid biosynthesis protein YP_001743085.1 1024688 D 439855 CDS YP_001743086.1 170683751 6147439 1025916..1026662 1 NC_010498.1 identified by match to protein family HMM PF00535; putative glycosyl transferase 1026662 wcaE 6147439 wcaE Escherichia coli SMS-3-5 putative glycosyl transferase YP_001743086.1 1025916 D 439855 CDS YP_001743087.1 170681739 6143043 1026678..1027226 1 NC_010498.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 1027226 6143043 EcSMS35_1008 Escherichia coli SMS-3-5 putative colanic acid biosynthesis acetyltransferase WcaF YP_001743087.1 1026678 D 439855 CDS YP_001743088.1 170680092 6145928 1027253..1028374 1 NC_010498.1 identified by match to protein family HMM PF01370; match to protein family HMM TIGR01472; GDP-mannose 4,6-dehydratase 1028374 gmd 6145928 gmd Escherichia coli SMS-3-5 GDP-mannose 4,6-dehydratase YP_001743088.1 1027253 D 439855 CDS YP_001743089.1 170682214 6144256 1028377..1029342 1 NC_010498.1 identified by match to protein family HMM PF01370; match to protein family HMM PF04321; GDP-L-fucose synthetase 1029342 fcl 6144256 fcl Escherichia coli SMS-3-5 GDP-L-fucose synthetase YP_001743089.1 1028377 D 439855 CDS YP_001743090.1 170682709 6146413 1029345..1029824 1 NC_010498.1 identified by match to protein family HMM PF00293; GDP-mannose mannosyl hydrolase 1029824 nudD 6146413 nudD Escherichia coli SMS-3-5 GDP-mannose mannosyl hydrolase YP_001743090.1 1029345 D 439855 CDS YP_001743091.1 170683742 6146917 1029821..1031044 1 NC_010498.1 identified by match to protein family HMM PF00534; putative glycosyl transferase 1031044 wcaI 6146917 wcaI Escherichia coli SMS-3-5 putative glycosyl transferase YP_001743091.1 1029821 D 439855 CDS YP_001743092.1 170682585 6143034 1031047..1032483 1 NC_010498.1 identified by similarity to SP:P24174; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; mannose-1-phosphate guanylyltransferase 1032483 cpsB 6143034 cpsB Escherichia coli SMS-3-5 mannose-1-phosphate guanylyltransferase YP_001743092.1 1031047 D 439855 CDS YP_001743093.1 170683098 6146790 1032585..1033955 1 NC_010498.1 identified by similarity to SP:P24175; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase 1033955 cpsG 6146790 cpsG Escherichia coli SMS-3-5 phosphomannomutase YP_001743093.1 1032585 D 439855 CDS YP_001743094.1 170682437 6147317 1034010..1035404 1 NC_010498.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 1035404 6147317 EcSMS35_1015 Escherichia coli SMS-3-5 putative UDP-glucose lipid carrier transferase YP_001743094.1 1034010 D 439855 CDS YP_001743095.1 170681740 6146636 1035406..1036884 1 NC_010498.1 identified by match to protein family HMM PF01943; colanic acid exporter 1036884 wzxC 6146636 wzxC Escherichia coli SMS-3-5 colanic acid exporter YP_001743095.1 1035406 D 439855 CDS YP_001743096.1 170683425 6145929 1036956..1038236 1 NC_010498.1 identified by match to protein family HMM PF04230; putative pyruvyl transferase 1038236 wcaK 6145929 wcaK Escherichia coli SMS-3-5 putative pyruvyl transferase YP_001743096.1 1036956 D 439855 CDS YP_001743097.1 170682752 6142712 1038233..1039453 1 NC_010498.1 identified by match to protein family HMM PF00534; colanic acid biosynthesis glycosyl transferase WcaL 1039453 wcaL 6142712 wcaL Escherichia coli SMS-3-5 colanic acid biosynthesis glycosyl transferase WcaL YP_001743097.1 1038233 D 439855 CDS YP_001743098.1 170679740 6146961 1039464..1040858 1 NC_010498.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 1040858 wcaM 6146961 wcaM Escherichia coli SMS-3-5 putative colanic acid biosynthesis protein YP_001743098.1 1039464 D 439855 CDS YP_001743099.1 170683772 6143898 1041016..1042011 1 NC_010498.1 identified by similarity to SP:Q8X7P7; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; UDP-N-acetylglucosamine 4-epimerase 1042011 gne 6143898 gne Escherichia coli SMS-3-5 UDP-N-acetylglucosamine 4-epimerase YP_001743099.1 1041016 D 439855 CDS YP_001743100.1 170680712 6143064 1042254..1043147 1 NC_010498.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 1043147 galF 6143064 galF Escherichia coli SMS-3-5 UTP--glucose-1-phosphate uridylyltransferase subunit GalF YP_001743100.1 1042254 D 439855 CDS YP_001743101.1 170680029 6144887 1043457..1044278 1 NC_010498.1 identified by match to protein family HMM PF00535; glycosyl transferase, group 2 1044278 6144887 EcSMS35_1022 Escherichia coli SMS-3-5 glycosyl transferase, group 2 YP_001743101.1 1043457 D 439855 CDS YP_001743102.1 170679679 6144192 1044280..1046046 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1046046 6144192 EcSMS35_1023 Escherichia coli SMS-3-5 hypothetical protein YP_001743102.1 1044280 D 439855 CDS YP_001743103.1 170681350 6143837 1046050..1046922 1 NC_010498.1 identified by match to protein family HMM PF00535; glycosyl transferase, group 2 1046922 6143837 EcSMS35_1024 Escherichia coli SMS-3-5 glycosyl transferase, group 2 YP_001743103.1 1046050 D 439855 CDS YP_001743104.1 170683073 6145534 1046922..1048100 1 NC_010498.1 hypothetical protein 1048100 6145534 EcSMS35_1025 Escherichia coli SMS-3-5 hypothetical protein YP_001743104.1 1046922 D 439855 CDS YP_001743105.1 170682395 6147290 1048051..1049076 1 NC_010498.1 identified by match to protein family HMM PF00534; glycosyl transferase, group 1 1049076 6147290 EcSMS35_1026 Escherichia coli SMS-3-5 glycosyl transferase, group 1 YP_001743105.1 1048051 D 439855 CDS YP_001743106.1 170682445 6146594 1049057..1050235 1 NC_010498.1 identified by match to protein family HMM PF01943; putative polysaccharide biosynthesis protein 1050235 6146594 EcSMS35_1027 Escherichia coli SMS-3-5 putative polysaccharide biosynthesis protein YP_001743106.1 1049057 D 439855 CDS YP_001743107.1 170683023 6146644 1050258..1050698 1 NC_010498.1 hypothetical protein 1050698 6146644 EcSMS35_1028 Escherichia coli SMS-3-5 hypothetical protein YP_001743107.1 1050258 D 439855 CDS YP_001743108.1 170684130 6147239 1050720..1050932 1 NC_010498.1 IS1 transposase orfA 1050932 6147239 EcSMS35_1029 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001743108.1 1050720 D 439855 CDS YP_001743109.1 170684151 6143430 1050943..1051446 1 NC_010498.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 1051446 6143430 EcSMS35_1030 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001743109.1 1050943 D 439855 CDS YP_001743110.1 170683458 6143451 1051833..1053239 1 NC_010498.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1053239 gnd 6143451 gnd Escherichia coli SMS-3-5 6-phosphogluconate dehydrogenase YP_001743110.1 1051833 D 439855 CDS YP_001743111.1 170680433 6142746 1053487..1054653 1 NC_010498.1 identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 1054653 ugd 6142746 ugd Escherichia coli SMS-3-5 UDP-glucose 6-dehydrogenase YP_001743111.1 1053487 D 439855 CDS YP_001743112.1 170680449 6144602 1054799..1055779 1 NC_010498.1 identified by match to protein family HMM PF02706; chain length determinant protein 1055779 6144602 EcSMS35_1033 Escherichia coli SMS-3-5 chain length determinant protein YP_001743112.1 1054799 D 439855 CDS YP_001743113.1 170679746 6144618 complement(1055875..1056486) 1 NC_010498.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 1056486 hisIE 6144618 hisIE Escherichia coli SMS-3-5 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein YP_001743113.1 1055875 R 439855 CDS YP_001743114.1 170679723 6143904 complement(1056480..1057256) 1 NC_010498.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1057256 hisF 6143904 hisF Escherichia coli SMS-3-5 imidazole glycerol phosphate synthase subunit HisF YP_001743114.1 1056480 R 439855 CDS YP_001743115.1 170680218 6143881 complement(1057238..1057975) 1 NC_010498.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1057975 hisA 6143881 hisA Escherichia coli SMS-3-5 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_001743115.1 1057238 R 439855 CDS YP_001743116.1 170680632 6144384 complement(1057975..1058565) 1 NC_010498.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1058565 hisH 6144384 hisH Escherichia coli SMS-3-5 imidazole glycerol phosphate synthase subunit HisH YP_001743116.1 1057975 R 439855 CDS YP_001743117.1 170683419 6144807 complement(1058565..1059632) 1 NC_010498.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 1059632 hisB 6144807 hisB Escherichia coli SMS-3-5 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_001743117.1 1058565 R 439855 CDS YP_001743118.1 170683323 6142706 complement(1059632..1060702) 1 NC_010498.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1060702 hisC 6142706 hisC Escherichia coli SMS-3-5 histidinol-phosphate aminotransferase YP_001743118.1 1059632 R 439855 CDS YP_001743119.1 170683888 6142608 complement(1060699..1062003) 1 NC_010498.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1062003 hisD 6142608 hisD Escherichia coli SMS-3-5 histidinol dehydrogenase YP_001743119.1 1060699 R 439855 CDS YP_001743120.1 170682673 6143183 complement(1062009..1062908) 1 NC_010498.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1062908 hisG 6143183 hisG Escherichia coli SMS-3-5 ATP phosphoribosyltransferase YP_001743120.1 1062009 R 439855 CDS YP_001743121.1 170680854 6146881 1063273..1063401 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1063401 6146881 EcSMS35_1042 Escherichia coli SMS-3-5 hypothetical protein YP_001743121.1 1063273 D 439855 CDS YP_001743122.1 170681380 6145031 1063531..1064355 1 NC_010498.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; NAD dependent epimerase/dehydratase family protein 1064355 6145031 EcSMS35_1043 Escherichia coli SMS-3-5 NAD dependent epimerase/dehydratase family protein YP_001743122.1 1063531 D 439855 CDS YP_001743123.1 170680006 6145564 1064401..1065330 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1065330 6145564 EcSMS35_1044 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743123.1 1064401 D 439855 CDS YP_001743124.1 170683794 6144169 1065597..1066955 1 NC_010498.1 identified by match to protein family HMM PF00324; amino acid permease 1066955 yeeF 6144169 yeeF Escherichia coli SMS-3-5 amino acid permease YP_001743124.1 1065597 D 439855 CDS YP_001743125.1 170681177 6143087 1066986..1067099 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1067099 6143087 EcSMS35_1046 Escherichia coli SMS-3-5 hypothetical protein YP_001743125.1 1066986 D 439855 CDS YP_001743126.1 170680499 6145361 1067134..1068192 1 NC_010498.1 identified by match to protein family HMM PF04143; YeeE/YedE family membrane protein 1068192 6145361 EcSMS35_1047 Escherichia coli SMS-3-5 YeeE/YedE family membrane protein YP_001743126.1 1067134 D 439855 CDS YP_001743127.1 170682996 6144668 1068206..1068433 1 NC_010498.1 identified by match to protein family HMM PF01206; hypothetical protein 1068433 6144668 EcSMS35_1048 Escherichia coli SMS-3-5 hypothetical protein YP_001743127.1 1068206 D 439855 CDS YP_001743128.1 170682338 6147212 complement(1068476..1069903) 1 NC_010498.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 1069903 sbcB 6147212 sbcB Escherichia coli SMS-3-5 exonuclease I YP_001743128.1 1068476 R 439855 CDS YP_001743129.1 170683165 6146537 complement(1070027..1070185) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1070185 6146537 EcSMS35_1050 Escherichia coli SMS-3-5 hypothetical protein YP_001743129.1 1070027 R 439855 CDS YP_001743130.1 170683658 6147385 1070106..1071278 1 NC_010498.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1071278 dacD 6147385 dacD Escherichia coli SMS-3-5 D-alanyl-D-alanine carboxypeptidase YP_001743130.1 1070106 D 439855 CDS YP_001743131.1 170680306 6142950 1071397..1071870 1 NC_010498.1 identified by match to protein family HMM PF06445; DNA gyrase inhibitor 1071870 gyrI 6142950 gyrI Escherichia coli SMS-3-5 DNA gyrase inhibitor YP_001743131.1 1071397 D 439855 CDS YP_001743132.1 170681607 6144474 1072068..1073126 1 NC_010498.1 hypothetical protein 1073126 6144474 EcSMS35_1054 Escherichia coli SMS-3-5 hypothetical protein YP_001743132.1 1072068 D 439855 CDS YP_001743133.1 170679578 6145792 complement(1073091..1073207) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1073207 6145792 EcSMS35_1053 Escherichia coli SMS-3-5 hypothetical protein YP_001743133.1 1073091 R 439855 CDS YP_001743134.1 170683170 6143735 1073298..1073627 1 NC_010498.1 identified by match to protein family HMM PF04363; hypothetical protein 1073627 6143735 EcSMS35_1055 Escherichia coli SMS-3-5 hypothetical protein YP_001743134.1 1073298 D 439855 CDS YP_001743135.1 170681688 6147390 complement(1073728..1074084) 1 NC_010498.1 identified by similarity to SP:Q8X8U4; hypothetical protein 1074084 6147390 EcSMS35_1056 Escherichia coli SMS-3-5 hypothetical protein YP_001743135.1 1073728 R 439855 CDS YP_001743136.1 170680134 6145874 complement(1074399..1074512) 1 NC_010498.1 hypothetical protein 1074512 6145874 EcSMS35_1057 Escherichia coli SMS-3-5 hypothetical protein YP_001743136.1 1074399 R 439855 CDS YP_001743137.1 170682087 6144300 complement(1074525..1074716) 1 NC_010498.1 hypothetical protein 1074716 6144300 EcSMS35_1058 Escherichia coli SMS-3-5 hypothetical protein YP_001743137.1 1074525 R 439855 CDS YP_001743138.1 170681113 6146284 complement(1074826..1075089) 1 NC_010498.1 identified by match to protein family HMM PF06755; hypothetical protein 1075089 6146284 EcSMS35_1059 Escherichia coli SMS-3-5 hypothetical protein YP_001743138.1 1074826 R 439855 CDS YP_001743139.1 170683206 6145296 complement(1075178..1075444) 1 NC_010498.1 identified by match to protein family HMM PF06154; hypothetical protein 1075444 6145296 EcSMS35_1060 Escherichia coli SMS-3-5 hypothetical protein YP_001743139.1 1075178 R 439855 CDS YP_001743140.1 170683714 6147427 complement(1075620..1075841) 1 NC_010498.1 identified by match to protein family HMM PF06174; hypothetical protein 1075841 6147427 EcSMS35_1061 Escherichia coli SMS-3-5 hypothetical protein YP_001743140.1 1075620 R 439855 CDS YP_001743141.1 170680081 6143006 complement(1075904..1076380) 1 NC_010498.1 identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 1076380 6143006 EcSMS35_1062 Escherichia coli SMS-3-5 RadC family DNA repair protein YP_001743141.1 1075904 R 439855 CDS YP_001743142.1 170680572 6144245 complement(1076396..1076875) 1 NC_010498.1 identified by match to protein family HMM PF03230; antirestriction protein 1076875 6144245 EcSMS35_1063 Escherichia coli SMS-3-5 antirestriction protein YP_001743142.1 1076396 R 439855 CDS YP_001743143.1 170681112 6144742 complement(1076957..1077778) 1 NC_010498.1 identified by match to protein family HMM PF06067; hypothetical protein 1077778 6144742 EcSMS35_1064 Escherichia coli SMS-3-5 hypothetical protein YP_001743143.1 1076957 R 439855 CDS YP_001743144.1 170680603 6145295 1077868..1078002 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1078002 6145295 EcSMS35_1066 Escherichia coli SMS-3-5 hypothetical protein YP_001743144.1 1077868 D 439855 CDS YP_001743145.1 170682565 6144777 complement(1077999..1078409) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1078409 6144777 EcSMS35_1065 Escherichia coli SMS-3-5 hypothetical protein YP_001743145.1 1077999 R 439855 CDS YP_001743146.1 170681111 6146770 complement(1078425..1079108) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1079108 6146770 EcSMS35_1067 Escherichia coli SMS-3-5 hypothetical protein YP_001743146.1 1078425 R 439855 CDS YP_001743147.1 170684069 6145294 complement(1079244..1080314) 1 NC_010498.1 identified by match to protein family HMM PF01734; patatin family phospholipase 1080314 6145294 EcSMS35_1068 Escherichia coli SMS-3-5 patatin family phospholipase YP_001743147.1 1079244 R 439855 CDS YP_001743148.1 170679812 6143369 complement(1080311..1081216) 1 NC_010498.1 identified by similarity to GB:AAP18661.1; hypothetical protein 1081216 6143369 EcSMS35_1069 Escherichia coli SMS-3-5 hypothetical protein YP_001743148.1 1080311 R 439855 CDS YP_001743149.1 170682670 6143973 complement(1081213..1083609) 1 NC_010498.1 identified by similarity to GB:AAZ90778.1; hypothetical protein 1083609 6143973 EcSMS35_1070 Escherichia coli SMS-3-5 hypothetical protein YP_001743149.1 1081213 R 439855 CDS YP_001743150.1 170683175 6146878 complement(1083827..1084699) 1 NC_010498.1 identified by match to protein family HMM PF01926; putative GTPase 1084699 6146878 EcSMS35_1071 Escherichia coli SMS-3-5 putative GTPase YP_001743150.1 1083827 R 439855 CDS YP_001743151.1 170681326 6147395 complement(1084783..1085934) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1085934 6147395 EcSMS35_1072 Escherichia coli SMS-3-5 hypothetical protein YP_001743151.1 1084783 R 439855 CDS YP_001743152.1 170681841 6145510 1087862..1088383 1 NC_010498.1 IS150 transposase orfA 1088383 6145510 EcSMS35_1073 Escherichia coli SMS-3-5 IS150 transposase orfA YP_001743152.1 1087862 D 439855 CDS YP_001743153.1 170679947 6146034 1088380..1089231 1 NC_010498.1 identified by match to protein family HMM PF00665; IS150 transposase orfB 1089231 6146034 EcSMS35_1074 Escherichia coli SMS-3-5 IS150 transposase orfB YP_001743153.1 1088380 D 439855 CDS YP_001743154.1 170684027 6144109 complement(1089774..1090376) 1 NC_010498.1 hypothetical protein 1090376 6144109 EcSMS35_1075 Escherichia coli SMS-3-5 hypothetical protein YP_001743154.1 1089774 R 439855 CDS YP_001743155.1 170682818 6143326 complement(1090470..1090676) 1 NC_010498.1 identified by match to protein family HMM PF05930; prophage CP4-57 regulatory protein AlpA 1090676 6143326 EcSMS35_1076 Escherichia coli SMS-3-5 prophage CP4-57 regulatory protein AlpA YP_001743155.1 1090470 R 439855 CDS YP_001743156.1 170679784 6147029 1092208..1092777 1 NC_010498.1 hypothetical protein 1092777 6147029 EcSMS35_1077 Escherichia coli SMS-3-5 hypothetical protein YP_001743156.1 1092208 D 439855 CDS YP_001743157.1 170683848 6143944 1093426..1093833 1 NC_010498.1 hypothetical protein 1093833 6143944 EcSMS35_1078 Escherichia coli SMS-3-5 hypothetical protein YP_001743157.1 1093426 D 439855 CDS YP_001743158.1 170680811 6143142 1094513..1095496 1 NC_010498.1 identified by match to protein family HMM PF01610; ISL3 family transposase 1095496 6143142 EcSMS35_1079 Escherichia coli SMS-3-5 ISL3 family transposase YP_001743158.1 1094513 D 439855 CDS YP_001743159.1 170681678 6144773 complement(1096148..1097182) 1 NC_010498.1 identified by match to protein family HMM PF02126; phosphotriesterase family protein 1097182 6144773 EcSMS35_1081 Escherichia coli SMS-3-5 phosphotriesterase family protein YP_001743159.1 1096148 R 439855 CDS YP_001743160.1 170682798 6145864 complement(1097185..1098150) 1 NC_010498.1 identified by match to protein family HMM PF04657; hypothetical protein 1098150 6145864 EcSMS35_1082 Escherichia coli SMS-3-5 hypothetical protein YP_001743160.1 1097185 R 439855 CDS YP_001743161.1 170682124 6147007 complement(1098207..1098965) 1 NC_010498.1 identified by similarity to GB:CAD08081.1; match to protein family HMM PF07090; hypothetical protein 1098965 6147007 EcSMS35_1083 Escherichia coli SMS-3-5 hypothetical protein YP_001743161.1 1098207 R 439855 CDS YP_001743162.1 170681818 6146323 complement(1098979..1100193) 1 NC_010498.1 identified by match to protein family HMM PF00294; match to protein family HMM PF08220; match to protein family HMM PF08279; match to protein family HMM PF08543; PfkB family DNA-binding protein/kinase 1100193 6146323 EcSMS35_1084 Escherichia coli SMS-3-5 PfkB family DNA-binding protein/kinase YP_001743162.1 1098979 R 439855 CDS YP_001743163.1 170682043 6146768 1101945..1102355 1 NC_010498.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1102355 6146768 EcSMS35_1086 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001743163.1 1101945 D 439855 CDS YP_001743164.1 170681774 6146240 1102313..1103218 1 NC_010498.1 identified by match to protein family HMM PF00665; IS2 transposase orfB 1103218 6146240 EcSMS35_1088 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001743164.1 1102313 D 439855 CDS YP_001743165.1 170682542 6145966 complement(1103143..1104309) 1 NC_010498.1 identified by match to protein family HMM PF00206; lyase 1104309 6145966 EcSMS35_1087 Escherichia coli SMS-3-5 lyase YP_001743165.1 1103143 R 439855 CDS YP_001743166.1 170683393 6146743 complement(1104532..1105830) 1 NC_010498.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1105830 6146743 EcSMS35_1089 Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001743166.1 1104532 R 439855 CDS YP_001743167.1 170683881 6142679 complement(1105889..1106608) 1 NC_010498.1 identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; aspartate racemase 1106608 6142679 EcSMS35_1090 Escherichia coli SMS-3-5 aspartate racemase YP_001743167.1 1105889 R 439855 CDS YP_001743168.1 170681745 6143176 1106948..1107847 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1107847 6143176 EcSMS35_1091 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743168.1 1106948 D 439855 CDS YP_001743169.1 170679921 6145935 1108117..1108251 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1108251 6145935 EcSMS35_1092 Escherichia coli SMS-3-5 hypothetical protein YP_001743169.1 1108117 D 439855 CDS YP_001743170.1 170680666 6146749 complement(1109201..1110493) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881; match to protein family HMM TIGR00893; d-galactonate transporter 1110493 6146749 EcSMS35_1094 Escherichia coli SMS-3-5 d-galactonate transporter YP_001743170.1 1109201 R 439855 CDS YP_001743171.1 170680994 6144841 complement(1110613..1111761) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; galactonate dehydratase 1111761 6144841 EcSMS35_1095 Escherichia coli SMS-3-5 galactonate dehydratase YP_001743171.1 1110613 R 439855 CDS YP_001743172.1 170681749 6145175 complement(1111758..1112375) 1 NC_010498.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 1112375 6145175 EcSMS35_1096 Escherichia coli SMS-3-5 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_001743172.1 1111758 R 439855 CDS YP_001743173.1 170682572 6145939 complement(1112359..1113237) 1 NC_010498.1 identified by similarity to SP:P31459; match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase 1113237 dgoK_2 6145939 dgoK_2 Escherichia coli SMS-3-5 2-dehydro-3-deoxygalactonokinase YP_001743173.1 1112359 R 439855 CDS YP_001743174.1 170680879 6146777 complement(1113234..1113923) 1 NC_010498.1 identified by similarity to SP:P31460; match to protein family HMM PF00392; match to protein family HMM PF07729; galactonate operon transcriptional repressor 1113923 dgoR_2 6146777 dgoR_2 Escherichia coli SMS-3-5 galactonate operon transcriptional repressor YP_001743174.1 1113234 R 439855 CDS YP_001743175.1 170682368 6145057 1114722..1114892 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1114892 6145057 EcSMS35_1099 Escherichia coli SMS-3-5 hypothetical protein YP_001743175.1 1114722 D 439855 CDS YP_001743176.1 170683061 6146567 1115155..1115466 1 NC_010498.1 identified by match to protein family HMM PF01527; IS911 transposase orfA 1115466 6146567 EcSMS35_1100 Escherichia coli SMS-3-5 IS911 transposase orfA YP_001743176.1 1115155 D 439855 CDS YP_001743177.1 170680489 6147278 1115586..1116332 1 NC_010498.1 identified by match to protein family HMM PF00665; IS911 transposase orfB 1116332 6147278 EcSMS35_1101 Escherichia coli SMS-3-5 IS911 transposase orfB YP_001743177.1 1115586 D 439855 CDS YP_001743178.1 170683576 6144658 1116552..1116686 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1116686 6144658 EcSMS35_1102 Escherichia coli SMS-3-5 hypothetical protein YP_001743178.1 1116552 D 439855 CDS YP_001743179.1 170682915 6142867 1117938..1119332 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 1119332 6142867 EcSMS35_1103 Escherichia coli SMS-3-5 major facilitator family transporter YP_001743179.1 1117938 D 439855 CDS YP_001743180.1 170680901 6147129 1119437..1120468 1 NC_010498.1 identified by match to protein family HMM PF00532; periplasmic sugar binding transcriptional regulator 1120468 6147129 EcSMS35_1104 Escherichia coli SMS-3-5 periplasmic sugar binding transcriptional regulator YP_001743180.1 1119437 D 439855 CDS YP_001743181.1 170681581 6145080 1120428..1121462 1 NC_010498.1 identified by match to protein family HMM PF01156; inosine-uridine preferring nucleoside hydrolase 1121462 6145080 EcSMS35_1105 Escherichia coli SMS-3-5 inosine-uridine preferring nucleoside hydrolase YP_001743181.1 1120428 D 439855 CDS YP_001743182.1 170679634 6145766 1121526..1122239 1 NC_010498.1 identified by match to protein family HMM PF02308; mgtC family protein 1122239 6145766 EcSMS35_1106 Escherichia coli SMS-3-5 mgtC family protein YP_001743182.1 1121526 D 439855 CDS YP_001743183.1 170682146 6143965 1125254..1125532 1 NC_010498.1 identified by similarity to GB:AAK03301.1; hypothetical protein 1125532 6143965 EcSMS35_1110 Escherichia coli SMS-3-5 hypothetical protein YP_001743183.1 1125254 D 439855 CDS YP_001743184.1 170682695 6146345 complement(1125870..1126901) 1 NC_010498.1 identified by match to protein family HMM PF01112; asparaginase family protein 1126901 6146345 EcSMS35_1111 Escherichia coli SMS-3-5 asparaginase family protein YP_001743184.1 1125870 R 439855 CDS YP_001743185.1 170680937 6146041 1128279..1128464 1 NC_010498.1 hypothetical protein 1128464 6146041 EcSMS35_1113 Escherichia coli SMS-3-5 hypothetical protein YP_001743185.1 1128279 D 439855 CDS YP_001743186.1 170679599 6145118 complement(1128517..1129878) 1 NC_010498.1 identified by similarity to SP:P0ABP3; match to protein family HMM PF03606; match to protein family HMM PF06808; match to protein family HMM TIGR00771; anaerobic C4-dicarboxylate transporter 1129878 6145118 EcSMS35_1114 Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001743186.1 1128517 R 439855 CDS YP_001743187.1 170683987 6143756 complement(1129875..1131131) 1 NC_010498.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1131131 6143756 EcSMS35_1115 Escherichia coli SMS-3-5 peptidase T YP_001743187.1 1129875 R 439855 CDS YP_001743188.1 170683617 6143285 1131997..1133397 1 NC_010498.1 identified by match to protein family HMM PF00206; putative aspartate ammonia-lyase 1133397 6143285 EcSMS35_1116 Escherichia coli SMS-3-5 putative aspartate ammonia-lyase YP_001743188.1 1131997 D 439855 CDS YP_001743189.1 170682600 6142907 1133553..1134887 1 NC_010498.1 identified by similarity to SP:P0ABN5; match to protein family HMM PF03600; match to protein family HMM PF03605; match to protein family HMM TIGR00770; anaerobic C4-dicarboxylate transporter 1134887 6142907 EcSMS35_1117 Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001743189.1 1133553 D 439855 CDS YP_001743190.1 170680917 6146805 1135375..1136421 1 NC_010498.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 1136421 ansB 6146805 ansB Escherichia coli SMS-3-5 L-asparaginase II YP_001743190.1 1135375 D 439855 CDS YP_001743191.1 170681636 6145098 complement(1137015..1137740) 1 NC_010498.1 identified by match to protein family HMM PF00072; response regulator 1137740 6145098 EcSMS35_1119 Escherichia coli SMS-3-5 response regulator YP_001743191.1 1137015 R 439855 CDS YP_001743192.1 170683932 6145822 complement(1138719..1139375) 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 1139375 6145822 EcSMS35_1120 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001743192.1 1138719 R 439855 CDS YP_001743193.1 170680566 6143228 1139530..1140846 1 NC_010498.1 identified by match to protein family HMM PF03600; match to protein family HMM PF03605; match to protein family HMM TIGR00770; anaerobic C4-dicarboxylate transporter 1140846 6143228 EcSMS35_1121 Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001743193.1 1139530 D 439855 CDS YP_001743194.1 170681956 6144736 complement(1140962..1142278) 1 NC_010498.1 identified by match to protein family HMM PF03600; match to protein family HMM PF03605; match to protein family HMM TIGR00770; anaerobic C4-dicarboxylate transporter 1142278 6144736 EcSMS35_1122 Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001743194.1 1140962 R 439855 CDS YP_001743195.1 170683952 6146152 complement(1142343..1143719) 1 NC_010498.1 identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838; argininosuccinate lyase ArgH-like protein 1143719 6146152 EcSMS35_1123 Escherichia coli SMS-3-5 argininosuccinate lyase ArgH-like protein YP_001743195.1 1142343 R 439855 CDS YP_001743196.1 170681244 6143249 1144378..1144767 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1144767 6143249 EcSMS35_1124 Escherichia coli SMS-3-5 hypothetical protein YP_001743196.1 1144378 D 439855 CDS YP_001743197.1 170682620 6145428 1145153..1146385 1 NC_010498.1 identified by similarity to GB:AAM53133.1; match to protein family HMM PF01507; immunoglobulin-binding regulator A-like protein 1146385 6145428 EcSMS35_1125 Escherichia coli SMS-3-5 immunoglobulin-binding regulator A-like protein YP_001743197.1 1145153 D 439855 CDS YP_001743198.1 170680569 6145819 complement(1147269..1147385) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1147385 6145819 EcSMS35_1127 Escherichia coli SMS-3-5 hypothetical protein YP_001743198.1 1147269 R 439855 CDS YP_001743199.1 170680206 6142628 1150574..1150738 1 NC_010498.1 hypothetical protein 1150738 6142628 EcSMS35_1129 Escherichia coli SMS-3-5 hypothetical protein YP_001743199.1 1150574 D 439855 CDS YP_001743200.1 170682332 6144372 1150929..1151051 1 NC_010498.1 hypothetical protein 1151051 6144372 EcSMS35_1130 Escherichia coli SMS-3-5 hypothetical protein YP_001743200.1 1150929 D 439855 CDS YP_001743201.1 170683924 6146531 1151203..1151748 1 NC_010498.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 1151748 cobU 6146531 cobU Escherichia coli SMS-3-5 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase YP_001743201.1 1151203 D 439855 CDS YP_001743202.1 170681294 6143220 1151745..1152488 1 NC_010498.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1152488 cobS 6143220 cobS Escherichia coli SMS-3-5 cobalamin synthase YP_001743202.1 1151745 D 439855 CDS YP_001743203.1 170682841 6145478 1152500..1153579 1 NC_010498.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1153579 cobT 6145478 cobT Escherichia coli SMS-3-5 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_001743203.1 1152500 D 439855 CDS YP_001743204.1 170681366 6147052 1153644..1154576 1 NC_010498.1 identified by match to protein family HMM PF03734; hypothetical protein 1154576 6147052 EcSMS35_1134 Escherichia coli SMS-3-5 hypothetical protein YP_001743204.1 1153644 D 439855 CDS YP_001743205.1 170680829 6143624 1155034..1155951 1 NC_010498.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 1155951 nac 6143624 nac Escherichia coli SMS-3-5 nitrogen assimilation transcriptional regulator YP_001743205.1 1155034 D 439855 CDS YP_001743206.1 170682115 6145006 1156053..1157003 1 NC_010498.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 1157003 cbl 6145006 cbl Escherichia coli SMS-3-5 transcriptional regulator Cbl YP_001743206.1 1156053 D 439855 CDS YP_001743207.1 170684252 6143626 1157310..1158764 1 NC_010498.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; hypothetical protein 1158764 6143626 EcSMS35_1139 Escherichia coli SMS-3-5 hypothetical protein YP_001743207.1 1157310 D 439855 CDS YP_001743208.1 170683768 6143702 1159179..1159301 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1159301 6143702 EcSMS35_1141 Escherichia coli SMS-3-5 hypothetical protein YP_001743208.1 1159179 D 439855 CDS YP_001743209.1 170679717 6143060 complement(1159392..1160108) 1 NC_010498.1 yeeN; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1160108 6143060 EcSMS35_1142 Escherichia coli SMS-3-5 hypothetical protein YP_001743209.1 1159392 R 439855 CDS YP_001743210.1 170679849 6143875 complement(1160451..1161905) 1 NC_010498.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 1161905 amn 6143875 amn Escherichia coli SMS-3-5 AMP nucleosidase YP_001743210.1 1160451 R 439855 CDS YP_001743211.1 170680503 6144011 complement(1162007..1163323) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; shikimate transporter 1163323 shiA 6144011 shiA Escherichia coli SMS-3-5 shikimate transporter YP_001743211.1 1162007 R 439855 CDS YP_001743212.1 170681197 6144672 1163638..1164690 1 NC_010498.1 hypothetical protein 1164690 6144672 EcSMS35_1145 Escherichia coli SMS-3-5 hypothetical protein YP_001743212.1 1163638 D 439855 CDS YP_001743213.1 170680815 6145381 complement(1164952..1172028) 1 NC_010498.1 yeeJ; identified by match to protein family HMM PF00801; match to protein family HMM PF02369; putative invasin 1172028 6145381 EcSMS35_1146 Escherichia coli SMS-3-5 putative invasin YP_001743213.1 1164952 R 439855 CDS YP_001743214.1 170681921 6143691 complement(1172518..1173315) 1 NC_010498.1 identified by match to protein family HMM PF06167; hypothetical protein 1173315 6143691 EcSMS35_1148 Escherichia coli SMS-3-5 hypothetical protein YP_001743214.1 1172518 R 439855 CDS YP_001743215.1 170682438 6143687 complement(1173551..1174576) 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 1174576 6143687 EcSMS35_1150 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001743215.1 1173551 R 439855 CDS YP_001743216.1 170684140 6146637 complement(1174576..1174779) 1 NC_010498.1 identified by similarity to GB:ABI42016.1; hypothetical protein 1174779 6146637 EcSMS35_1151 Escherichia coli SMS-3-5 hypothetical protein YP_001743216.1 1174576 R 439855 CDS YP_001743217.1 170684076 6143440 complement(1174838..1177279) 1 NC_010498.1 identified by match to protein family HMM PF00929; match to protein family HMM PF06630; exonuclease family protein 1177279 6143440 EcSMS35_1152 Escherichia coli SMS-3-5 exonuclease family protein YP_001743217.1 1174838 R 439855 CDS YP_001743218.1 170684084 6143376 complement(1177373..1177564) 1 NC_010498.1 identified by match to protein family HMM PF07358; hypothetical protein 1177564 6143376 EcSMS35_1153 Escherichia coli SMS-3-5 hypothetical protein YP_001743218.1 1177373 R 439855 CDS YP_001743219.1 170680399 6143384 complement(1177561..1177749) 1 NC_010498.1 identified by match to protein family HMM PF05358; division inhibition protein DicB 1177749 dicB 6143384 dicB Escherichia coli SMS-3-5 division inhibition protein DicB YP_001743219.1 1177561 R 439855 CDS YP_001743220.1 170679757 6144568 1177766..1177888 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1177888 6144568 EcSMS35_1155 Escherichia coli SMS-3-5 hypothetical protein YP_001743220.1 1177766 D 439855 CDS YP_001743221.1 170681828 6143916 complement(1178317..1178535) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1178535 6143916 EcSMS35_1156 Escherichia coli SMS-3-5 hypothetical protein YP_001743221.1 1178317 R 439855 CDS YP_001743222.1 170681832 6146021 complement(1178565..1178693) 1 NC_010498.1 ydfB; identified by Glimmer3; putative; hypothetical protein 1178693 6146021 EcSMS35_1157 Escherichia coli SMS-3-5 hypothetical protein YP_001743222.1 1178565 R 439855 CDS YP_001743223.1 170681288 6146025 complement(1178695..1178850) 1 NC_010498.1 identified by match to protein family HMM PF07151; hypothetical protein 1178850 6146025 EcSMS35_1158 Escherichia coli SMS-3-5 hypothetical protein YP_001743223.1 1178695 R 439855 CDS YP_001743224.1 170682538 6145472 1179525..1179752 1 NC_010498.1 DNA-binding transcriptional regulator DicC 1179752 6145472 EcSMS35_1159 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator DicC YP_001743224.1 1179525 D 439855 CDS YP_001743225.1 170682019 6146739 1179736..1180287 1 NC_010498.1 identified by match to protein family HMM PF06254; hypothetical protein 1180287 6146739 EcSMS35_1160 Escherichia coli SMS-3-5 hypothetical protein YP_001743225.1 1179736 D 439855 CDS YP_001743226.1 170681092 6146216 1180259..1181299 1 NC_010498.1 hypothetical protein 1181299 6146216 EcSMS35_1161 Escherichia coli SMS-3-5 hypothetical protein YP_001743226.1 1180259 D 439855 CDS YP_001743227.1 170680860 6145274 1181331..1181753 1 NC_010498.1 hypothetical protein 1181753 6145274 EcSMS35_1162 Escherichia coli SMS-3-5 hypothetical protein YP_001743227.1 1181331 D 439855 CDS YP_001743228.1 170684045 6145037 1181787..1182557 1 NC_010498.1 identified by match to protein family HMM PF07789; hypothetical protein 1182557 6145037 EcSMS35_1163 Escherichia coli SMS-3-5 hypothetical protein YP_001743228.1 1181787 D 439855 CDS YP_001743229.1 170680112 6143344 1182573..1182965 1 NC_010498.1 identified by similarity to GB:CAD05604.1; match to protein family HMM PF06163; hypothetical protein 1182965 6143344 EcSMS35_1164 Escherichia coli SMS-3-5 hypothetical protein YP_001743229.1 1182573 D 439855 CDS YP_001743230.1 170683295 6144277 1182962..1183258 1 NC_010498.1 identified by similarity to GB:ABE56533.1; hypothetical protein 1183258 6144277 EcSMS35_1165 Escherichia coli SMS-3-5 hypothetical protein YP_001743230.1 1182962 D 439855 CDS YP_001743231.1 170683528 6147521 1183255..1183716 1 NC_010498.1 identified by similarity to GB:AAK28855.1; hypothetical protein 1183716 6147521 EcSMS35_1166 Escherichia coli SMS-3-5 hypothetical protein YP_001743231.1 1183255 D 439855 CDS YP_001743232.1 170681969 6142818 1183694..1184050 1 NC_010498.1 identified by similarity to GB:ABF03554.1; hypothetical protein 1184050 6142818 EcSMS35_1167 Escherichia coli SMS-3-5 hypothetical protein YP_001743232.1 1183694 D 439855 CDS YP_001743233.1 170682805 6146165 1184144..1184326 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1184326 6146165 EcSMS35_1168 Escherichia coli SMS-3-5 hypothetical protein YP_001743233.1 1184144 D 439855 CDS YP_001743234.1 170681299 6147016 1184319..1184495 1 NC_010498.1 identified by similarity to GB:BAB93828.1; hypothetical protein 1184495 6147016 EcSMS35_1169 Escherichia coli SMS-3-5 hypothetical protein YP_001743234.1 1184319 D 439855 CDS YP_001743235.1 170681435 6145483 1184492..1185007 1 NC_010498.1 identified by similarity to GB:ABF04172.1; hypothetical protein 1185007 6145483 EcSMS35_1170 Escherichia coli SMS-3-5 hypothetical protein YP_001743235.1 1184492 D 439855 CDS YP_001743236.1 170679925 6145619 1185211..1185339 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1185339 6145619 EcSMS35_1171 Escherichia coli SMS-3-5 hypothetical protein YP_001743236.1 1185211 D 439855 CDS YP_001743237.1 170681041 6144087 1185927..1186187 1 NC_010498.1 hypothetical protein 1186187 6144087 EcSMS35_1172 Escherichia coli SMS-3-5 hypothetical protein YP_001743237.1 1185927 D 439855 CDS YP_001743238.1 170683838 6145222 complement(1186201..1186332) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1186332 6145222 EcSMS35_1173 Escherichia coli SMS-3-5 hypothetical protein YP_001743238.1 1186201 R 439855 CDS YP_001743239.1 170680695 6143132 1186534..1187589 1 NC_010498.1 identified by match to protein family HMM PF06914; hypothetical protein 1187589 6143132 EcSMS35_1174 Escherichia coli SMS-3-5 hypothetical protein YP_001743239.1 1186534 D 439855 CDS YP_001743240.1 170682821 6144870 1187590..1187955 1 NC_010498.1 identified by match to protein family HMM PF05866; crossover junction endodeoxyribonuclease RusA-like protein 1187955 6144870 EcSMS35_1175 Escherichia coli SMS-3-5 crossover junction endodeoxyribonuclease RusA-like protein YP_001743240.1 1187590 D 439855 CDS YP_001743241.1 170683145 6147032 1187952..1188641 1 NC_010498.1 identified by similarity to SP:P13870; match to protein family HMM PF06323; antitermination protein Q 1188641 6147032 EcSMS35_1176 Escherichia coli SMS-3-5 antitermination protein Q YP_001743241.1 1187952 D 439855 CDS YP_001743242.1 170682094 6143633 1189437..1189652 1 NC_010498.1 identified by match to protein family HMM PF04971; lambda phage S protein family protein 1189652 6143633 EcSMS35_1181 Escherichia coli SMS-3-5 lambda phage S protein family protein YP_001743242.1 1189437 D 439855 CDS YP_001743243.1 170682762 6146292 1189657..1190007 1 NC_010498.1 ydfR; identified by match to protein family HMM PF07041; hypothetical protein 1190007 6146292 EcSMS35_1182 Escherichia coli SMS-3-5 hypothetical protein YP_001743243.1 1189657 D 439855 CDS YP_001743244.1 170681309 6146971 1190071..1190604 1 NC_010498.1 identified by match to protein family HMM PF00959; phage lysozyme 1190604 6146971 EcSMS35_1183 Escherichia coli SMS-3-5 phage lysozyme YP_001743244.1 1190071 D 439855 CDS YP_001743245.1 170681692 6145493 1190601..1191068 1 NC_010498.1 identified by match to protein family HMM PF03245; bacteriophage lysis protein 1191068 6145493 EcSMS35_1184 Escherichia coli SMS-3-5 bacteriophage lysis protein YP_001743245.1 1190601 D 439855 CDS YP_001743246.1 170682014 6145878 1191610..1192092 1 NC_010498.1 identified by match to protein family HMM PF05119; match to protein family HMM TIGR01558; P27 family phage terminase small subunit 1192092 6145878 EcSMS35_1185 Escherichia coli SMS-3-5 P27 family phage terminase small subunit YP_001743246.1 1191610 D 439855 CDS YP_001743247.1 170684273 6146211 1192092..1193849 1 NC_010498.1 identified by match to protein family HMM PF03354; putative phage terminase, large subunit 1193849 6146211 EcSMS35_1186 Escherichia coli SMS-3-5 putative phage terminase, large subunit YP_001743247.1 1192092 D 439855 CDS YP_001743248.1 170680780 6143575 1193861..1194043 1 NC_010498.1 identified by similarity to GB:AAZ89395.1; hypothetical protein 1194043 6143575 EcSMS35_1187 Escherichia coli SMS-3-5 hypothetical protein YP_001743248.1 1193861 D 439855 CDS YP_001743249.1 170682704 6144955 1194043..1195284 1 NC_010498.1 identified by match to protein family HMM PF04860; match to protein family HMM TIGR01537; HK97 family phage portal protein 1195284 6144955 EcSMS35_1188 Escherichia coli SMS-3-5 HK97 family phage portal protein YP_001743249.1 1194043 D 439855 CDS YP_001743250.1 170679829 6146912 1195262..1195912 1 NC_010498.1 identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543; HK97 family phage prohead protease 1195912 6146912 EcSMS35_1189 Escherichia coli SMS-3-5 HK97 family phage prohead protease YP_001743250.1 1195262 D 439855 CDS YP_001743251.1 170681147 6143991 1195927..1197132 1 NC_010498.1 identified by match to protein family HMM PF05065; match to protein family HMM TIGR01554; HK97 family phage major capsid protein 1197132 6143991 EcSMS35_1190 Escherichia coli SMS-3-5 HK97 family phage major capsid protein YP_001743251.1 1195927 D 439855 CDS YP_001743252.1 170680595 6145330 1197184..1197372 1 NC_010498.1 identified by similarity to GB:ABF02516.1; hypothetical protein 1197372 6145330 EcSMS35_1191 Escherichia coli SMS-3-5 hypothetical protein YP_001743252.1 1197184 D 439855 CDS YP_001743253.1 170680152 6144767 1197384..1197689 1 NC_010498.1 identified by similarity to GB:AAL89415.1; hypothetical protein 1197689 6144767 EcSMS35_1192 Escherichia coli SMS-3-5 hypothetical protein YP_001743253.1 1197384 D 439855 CDS YP_001743254.1 170683712 6144318 1198036..1198482 1 NC_010498.1 identified by match to protein family HMM PF07772; match to protein family HMM TIGR01725; HK97 family phage protein 1198482 6144318 EcSMS35_1193 Escherichia coli SMS-3-5 HK97 family phage protein YP_001743254.1 1198036 D 439855 CDS YP_001743255.1 170683199 6143004 1198479..1198823 1 NC_010498.1 identified by similarity to GB:ABP60903.1; hypothetical protein 1198823 6143004 EcSMS35_1194 Escherichia coli SMS-3-5 hypothetical protein YP_001743255.1 1198479 D 439855 CDS YP_001743256.1 170682737 6147419 1198883..1199587 1 NC_010498.1 identified by similarity to GB:AAF31091.1; hypothetical protein 1199587 6147419 EcSMS35_1195 Escherichia coli SMS-3-5 hypothetical protein YP_001743256.1 1198883 D 439855 CDS YP_001743257.1 170680726 6146945 1199602..1199973 1 NC_010498.1 identified by match to protein family HMM PF06222; phage tail assembly chaperone 1199973 6146945 EcSMS35_1196 Escherichia coli SMS-3-5 phage tail assembly chaperone YP_001743257.1 1199602 D 439855 CDS YP_001743258.1 170682420 6144901 1199985..1200275 1 NC_010498.1 identified by similarity to GB:AAL40287.1; hypothetical protein 1200275 6144901 EcSMS35_1197 Escherichia coli SMS-3-5 hypothetical protein YP_001743258.1 1199985 D 439855 CDS YP_001743259.1 170684087 6146619 1200321..1203548 1 NC_010498.1 identified by match to protein family HMM TIGR01541; match to protein family HMM TIGR02675; lambda family phage tail tape measure protein 1203548 6146619 EcSMS35_1198 Escherichia coli SMS-3-5 lambda family phage tail tape measure protein YP_001743259.1 1200321 D 439855 CDS YP_001743260.1 170681039 6143387 1203541..1203882 1 NC_010498.1 identified by match to protein family HMM PF05939; phage minor tail protein 1203882 6143387 EcSMS35_1199 Escherichia coli SMS-3-5 phage minor tail protein YP_001743260.1 1203541 D 439855 CDS YP_001743261.1 170682811 6145220 1203882..1204580 1 NC_010498.1 identified by match to protein family HMM PF05100; match to protein family HMM TIGR01600; phage minor tail protein L 1204580 6145220 EcSMS35_1200 Escherichia coli SMS-3-5 phage minor tail protein L YP_001743261.1 1203882 D 439855 CDS YP_001743262.1 170679766 6147022 1204585..1205328 1 NC_010498.1 identified by match to protein family HMM PF00877; tail assembly protein 1205328 6147022 EcSMS35_1201 Escherichia coli SMS-3-5 tail assembly protein YP_001743262.1 1204585 D 439855 CDS YP_001743263.1 170681407 6143925 1205226..1205873 1 NC_010498.1 identified by match to protein family HMM PF06805; bacteriophage lambda tail assembly protein I 1205873 6143925 EcSMS35_1202 Escherichia coli SMS-3-5 bacteriophage lambda tail assembly protein I YP_001743263.1 1205226 D 439855 CDS YP_001743264.1 170683152 6145591 1205934..1209413 1 NC_010498.1 identified by match to protein family HMM PF00041; match to protein family HMM PF09327; fibronectin type III domain-containing protein 1209413 6145591 EcSMS35_1203 Escherichia coli SMS-3-5 fibronectin type III domain-containing protein YP_001743264.1 1205934 D 439855 CDS YP_001743265.1 170683605 6147372 1209481..1210080 1 NC_010498.1 identified by match to protein family HMM PF06316; Ail/Lom family protein 1210080 6147372 EcSMS35_1204 Escherichia coli SMS-3-5 Ail/Lom family protein YP_001743265.1 1209481 D 439855 CDS YP_001743266.1 170679883 6142895 1210145..1212682 1 NC_010498.1 identified by match to protein family HMM PF08400; putative prophage side tail fiber protein 1212682 6142895 EcSMS35_1206 Escherichia coli SMS-3-5 putative prophage side tail fiber protein YP_001743266.1 1210145 D 439855 CDS YP_001743267.1 170684292 6144045 complement(1212522..1213427) 1 NC_010498.1 identified by similarity to SP:P51026; IS2 transposase orfB 1213427 6144045 EcSMS35_1205 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001743267.1 1212522 R 439855 CDS YP_001743268.1 170682700 6143594 complement(1213385..1213795) 1 NC_010498.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1213795 6143594 EcSMS35_1207 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001743268.1 1213385 R 439855 CDS YP_001743269.1 170683066 6146908 1213859..1214140 1 NC_010498.1 identified by similarity to GB:BAB97540.1; hypothetical protein 1214140 6146908 EcSMS35_1208 Escherichia coli SMS-3-5 hypothetical protein YP_001743269.1 1213859 D 439855 CDS YP_001743270.1 170682042 6147283 1214150..1215190 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1215190 6147283 EcSMS35_1209 Escherichia coli SMS-3-5 hypothetical protein YP_001743270.1 1214150 D 439855 CDS YP_001743271.1 170684071 6146239 1215227..1215520 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1215520 6146239 EcSMS35_1210 Escherichia coli SMS-3-5 hypothetical protein YP_001743271.1 1215227 D 439855 CDS YP_001743272.1 170683690 6143371 complement(1216501..1217031) 1 NC_010498.1 identified by match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit 1217031 6143371 EcSMS35_1211 Escherichia coli SMS-3-5 nickel-dependent hydrogenase, b-type cytochrome subunit YP_001743272.1 1216501 R 439855 CDS YP_001743273.1 170680325 6142982 complement(1217374..1218024) 1 NC_010498.1 identified by match to protein family HMM PF09223; hypothetical protein 1218024 6142982 EcSMS35_1212 Escherichia coli SMS-3-5 hypothetical protein YP_001743273.1 1217374 R 439855 CDS YP_001743274.1 170681710 6144493 complement(1218281..1218916) 1 NC_010498.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 1218916 6144493 EcSMS35_1213 Escherichia coli SMS-3-5 putative sulfite oxidase subunit YedZ YP_001743274.1 1218281 R 439855 CDS YP_001743275.1 170681163 6145897 complement(1218917..1219921) 1 NC_010498.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 1219921 6145897 EcSMS35_1214 Escherichia coli SMS-3-5 putative sulfite oxidase subunit YedY YP_001743275.1 1218917 R 439855 CDS YP_001743276.1 170680340 6145347 complement(1220030..1220443) 1 NC_010498.1 identified by match to protein family HMM PF00576; match to protein family HMM TIGR02962; transthyretin family protein 1220443 6145347 EcSMS35_1215 Escherichia coli SMS-3-5 transthyretin family protein YP_001743276.1 1220030 R 439855 CDS YP_001743277.1 170680782 6144508 1220465..1221247 1 NC_010498.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 1221247 6144508 EcSMS35_1216 Escherichia coli SMS-3-5 transcriptional regulatory protein YedW YP_001743277.1 1220465 D 439855 CDS YP_001743278.1 170681228 6144957 1221247..1222605 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386; heavy metal sensor histidine kinase 1222605 6144957 EcSMS35_1217 Escherichia coli SMS-3-5 heavy metal sensor histidine kinase YP_001743278.1 1221247 D 439855 CDS YP_001743279.1 170684248 6145412 complement(1222712..1223563) 1 NC_010498.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 1223563 hchA 6145412 hchA Escherichia coli SMS-3-5 chaperone protein HchA YP_001743279.1 1222712 R 439855 CDS YP_001743280.1 170682226 6143550 complement(1223584..1223727) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1223727 6143550 EcSMS35_1219 Escherichia coli SMS-3-5 hypothetical protein YP_001743280.1 1223584 R 439855 CDS YP_001743281.1 170684218 6146425 1223987..1224154 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1224154 6146425 EcSMS35_1220 Escherichia coli SMS-3-5 hypothetical protein YP_001743281.1 1223987 D 439855 CDS YP_001743282.1 170682358 6143519 complement(1224155..1225318) 1 NC_010498.1 identified by similarity to SP:P77747; match to protein family HMM PF00267; porin family protein 1225318 6143519 EcSMS35_1221 Escherichia coli SMS-3-5 porin family protein YP_001743282.1 1224155 R 439855 CDS YP_001743283.1 170680391 6146557 1225949..1226251 1 NC_010498.1 hypothetical protein 1226251 6146557 EcSMS35_1222 Escherichia coli SMS-3-5 hypothetical protein YP_001743283.1 1225949 D 439855 CDS YP_001743284.1 170683271 6144560 1226291..1226986 1 NC_010498.1 identified by match to protein family HMM PF01966; hypothetical protein 1226986 6144560 EcSMS35_1223 Escherichia coli SMS-3-5 hypothetical protein YP_001743284.1 1226291 D 439855 CDS YP_001743285.1 170681403 6147496 1227053..1228471 1 NC_010498.1 identified by similarity to SP:P0AED9; match to protein family HMM PF00145; match to protein family HMM TIGR00675; DNA cytosine methylase 1228471 dcm 6147496 dcm Escherichia coli SMS-3-5 DNA cytosine methylase YP_001743285.1 1227053 D 439855 CDS YP_001743286.1 170683555 6145587 1228452..1228922 1 NC_010498.1 identified by match to protein family HMM PF03852; match to protein family HMM TIGR00632; very short patch repair protein 1228922 vsr 6145587 vsr Escherichia coli SMS-3-5 very short patch repair protein YP_001743286.1 1228452 D 439855 CDS YP_001743287.1 170681707 6142845 complement(1228911..1229831) 1 NC_010498.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; hypothetical protein 1229831 6142845 EcSMS35_1225 Escherichia coli SMS-3-5 hypothetical protein YP_001743287.1 1228911 R 439855 CDS YP_001743288.1 170680681 6145894 1230010..1230921 1 NC_010498.1 identified by match to protein family HMM PF05661; hypothetical protein 1230921 6145894 EcSMS35_1227 Escherichia coli SMS-3-5 hypothetical protein YP_001743288.1 1230010 D 439855 CDS YP_001743289.1 170682491 6144856 1231000..1231182 1 NC_010498.1 hypothetical protein 1231182 6144856 EcSMS35_1228 Escherichia coli SMS-3-5 hypothetical protein YP_001743289.1 1231000 D 439855 CDS YP_001743290.1 170680876 6146690 1231371..1233047 1 NC_010498.1 yedQ; identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1233047 6146690 EcSMS35_1230 Escherichia coli SMS-3-5 diguanylate cyclase YP_001743290.1 1231371 D 439855 CDS YP_001743291.1 170684226 6145054 complement(1233044..1233859) 1 NC_010498.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 1233859 6145054 EcSMS35_1229 Escherichia coli SMS-3-5 mannosyl-3-phosphoglycerate phosphatase YP_001743291.1 1233044 R 439855 CDS YP_001743292.1 170682583 6143527 complement(1234156..1234383) 1 NC_010498.1 hypothetical protein 1234383 6143527 EcSMS35_1231 Escherichia coli SMS-3-5 hypothetical protein YP_001743292.1 1234156 R 439855 CDS YP_001743293.1 170680957 6146788 1234546..1234734 1 NC_010498.1 hypothetical protein 1234734 6146788 EcSMS35_1232 Escherichia coli SMS-3-5 hypothetical protein YP_001743293.1 1234546 D 439855 CDS YP_001743294.1 170682602 6145138 complement(1234778..1235401) 1 NC_010498.1 identified by match to protein family HMM PF00196; colanic acid capsular biosynthesis activation protein A 1235401 rcsA 6145138 rcsA Escherichia coli SMS-3-5 colanic acid capsular biosynthesis activation protein A YP_001743294.1 1234778 R 439855 CDS YP_001743295.1 170679575 6146807 complement(1235691..1236476) 1 NC_010498.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 1236476 fliR 6146807 fliR Escherichia coli SMS-3-5 flagellar biosynthesis protein FliR YP_001743295.1 1235691 R 439855 CDS YP_001743296.1 170681533 6143732 complement(1236485..1236754) 1 NC_010498.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 1236754 fliQ 6143732 fliQ Escherichia coli SMS-3-5 flagellar biosynthesis protein FliQ YP_001743296.1 1236485 R 439855 CDS YP_001743297.1 170682430 6145718 complement(1236764..1237501) 1 NC_010498.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 1237501 fliP 6145718 fliP Escherichia coli SMS-3-5 flagellar biosynthesis protein FliP YP_001743297.1 1236764 R 439855 CDS YP_001743298.1 170682928 6146629 complement(1237501..1237866) 1 NC_010498.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 1237866 fliO 6146629 fliO Escherichia coli SMS-3-5 flagellar biosynthesis protein FliO YP_001743298.1 1237501 R 439855 CDS YP_001743299.1 170683738 6147142 complement(1237869..1238282) 1 NC_010498.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 1238282 fliN 6147142 fliN Escherichia coli SMS-3-5 flagellar motor switch protein FliN YP_001743299.1 1237869 R 439855 CDS YP_001743300.1 170684212 6143030 complement(1238279..1239283) 1 NC_010498.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 1239283 fliM 6143030 fliM Escherichia coli SMS-3-5 flagellar motor switch protein FliM YP_001743300.1 1238279 R 439855 CDS YP_001743301.1 170682191 6143513 complement(1239288..1239752) 1 NC_010498.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 1239752 fliL 6143513 fliL Escherichia coli SMS-3-5 flagellar basal body-associated protein FliL YP_001743301.1 1239288 R 439855 CDS YP_001743302.1 170682141 6146390 complement(1239857..1240984) 1 NC_010498.1 identified by match to protein family HMM PF02120; flagellar hook-length control protein 1240984 fliK 6146390 fliK Escherichia coli SMS-3-5 flagellar hook-length control protein YP_001743302.1 1239857 R 439855 CDS YP_001743303.1 170680856 6146340 complement(1240981..1241424) 1 NC_010498.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 1241424 fliJ 6146340 fliJ Escherichia coli SMS-3-5 flagellar biosynthesis chaperone YP_001743303.1 1240981 R 439855 CDS YP_001743304.1 170682688 6145033 complement(1241443..1242816) 1 NC_010498.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 1242816 fliI 6145033 fliI Escherichia coli SMS-3-5 flagellum-specific ATP synthase YP_001743304.1 1241443 R 439855 CDS YP_001743305.1 170679677 6146896 complement(1242816..1243502) 1 NC_010498.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 1243502 fliH 6146896 fliH Escherichia coli SMS-3-5 flagellar assembly protein H YP_001743305.1 1242816 R 439855 CDS YP_001743306.1 170681479 6143835 complement(1243495..1244490) 1 NC_010498.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 1244490 fliG 6143835 fliG Escherichia coli SMS-3-5 flagellar motor switch protein G YP_001743306.1 1243495 R 439855 CDS YP_001743307.1 170682432 6145664 complement(1244483..1246141) 1 NC_010498.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 1246141 fliF 6145664 fliF Escherichia coli SMS-3-5 flagellar MS-ring protein YP_001743307.1 1244483 R 439855 CDS YP_001743308.1 170682525 6146631 1246356..1246670 1 NC_010498.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 1246670 fliE 6146631 fliE Escherichia coli SMS-3-5 flagellar hook-basal body protein FliE YP_001743308.1 1246356 D 439855 CDS YP_001743309.1 170684152 6146726 1247021..1248160 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1248160 6146726 EcSMS35_1248 Escherichia coli SMS-3-5 hypothetical protein YP_001743309.1 1247021 D 439855 CDS YP_001743310.1 170682423 6143452 complement(1248298..1248777) 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 1248777 6143452 EcSMS35_1249 Escherichia coli SMS-3-5 acetyltransferase YP_001743310.1 1248298 R 439855 CDS YP_001743311.1 170679801 6146622 complement(1248888..1249556) 1 NC_010498.1 yedK; identified by match to protein family HMM PF02586; hypothetical protein 1249556 6146622 EcSMS35_1250 Escherichia coli SMS-3-5 hypothetical protein YP_001743311.1 1248888 R 439855 CDS YP_001743312.1 170680412 6143961 complement(1249665..1249898) 1 NC_010498.1 identified by match to protein family HMM PF01206; hypothetical protein 1249898 6143961 EcSMS35_1251 Escherichia coli SMS-3-5 hypothetical protein YP_001743312.1 1249665 R 439855 CDS YP_001743313.1 170683280 6144581 complement(1249895..1251100) 1 NC_010498.1 identified by match to protein family HMM PF04143; putative inner membrane protein 1251100 6144581 EcSMS35_1252 Escherichia coli SMS-3-5 putative inner membrane protein YP_001743313.1 1249895 R 439855 CDS YP_001743314.1 170683504 6147506 1251287..1251700 1 NC_010498.1 hypothetical protein 1251700 6147506 EcSMS35_1253 Escherichia coli SMS-3-5 hypothetical protein YP_001743314.1 1251287 D 439855 CDS YP_001743315.1 170679614 6142793 complement(1251734..1253221) 1 NC_010498.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1253221 amyA 6142793 amyA Escherichia coli SMS-3-5 cytoplasmic alpha-amylase YP_001743315.1 1251734 R 439855 CDS YP_001743316.1 170683221 6143771 complement(1253299..1253664) 1 NC_010498.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 1253664 fliT 6143771 fliT Escherichia coli SMS-3-5 flagellar biosynthesis protein FliT YP_001743316.1 1253299 R 439855 CDS YP_001743317.1 170680836 6147442 complement(1253664..1254074) 1 NC_010498.1 flagellin specific chaperone; flagellar protein FliS 1254074 fliS 6147442 fliS Escherichia coli SMS-3-5 flagellar protein FliS YP_001743317.1 1253664 R 439855 CDS YP_001743318.1 170680620 6145013 complement(1254099..1255505) 1 NC_010498.1 involved in flagellin assembly; flagellar capping protein 1255505 fliD 6145013 fliD Escherichia coli SMS-3-5 flagellar capping protein YP_001743318.1 1254099 R 439855 CDS YP_001743319.1 170682489 6144795 1255771..1257408 1 NC_010498.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 1257408 fliC 6144795 fliC Escherichia coli SMS-3-5 flagellin YP_001743319.1 1255771 D 439855 CDS YP_001743320.1 170681651 6146688 complement(1257535..1257654) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1257654 6146688 EcSMS35_1259 Escherichia coli SMS-3-5 hypothetical protein YP_001743320.1 1257535 R 439855 CDS YP_001743321.1 170684004 6145837 1257728..1258447 1 NC_010498.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1258447 fliA 6145837 fliA Escherichia coli SMS-3-5 flagellar biosynthesis sigma factor YP_001743321.1 1257728 D 439855 CDS YP_001743322.1 170682675 6143303 1258493..1259044 1 NC_010498.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 1259044 6143303 EcSMS35_1261 Escherichia coli SMS-3-5 flagella biosynthesis protein FliZ YP_001743322.1 1258493 D 439855 CDS YP_001743323.1 170679839 6146883 1259132..1259932 1 NC_010498.1 identified by match to protein family HMM PF00497; cystine transporter subunit 1259932 fliY 6146883 fliY Escherichia coli SMS-3-5 cystine transporter subunit YP_001743323.1 1259132 D 439855 CDS YP_001743324.1 170683740 6144001 1260037..1261023 1 NC_010498.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1261023 dcyD 6144001 dcyD Escherichia coli SMS-3-5 D-cysteine desulfhydrase YP_001743324.1 1260037 D 439855 CDS YP_001743325.1 170681367 6143032 1261038..1261706 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; L-cystine ABC transporter permease 1261706 6143032 EcSMS35_1264 Escherichia coli SMS-3-5 L-cystine ABC transporter permease YP_001743325.1 1261038 D 439855 CDS YP_001743326.1 170681735 6145551 1261703..1262455 1 NC_010498.1 identified by match to protein family HMM PF00005; putative amino-acid ABC transporter ATP-binding protein YecC 1262455 yecC 6145551 yecC Escherichia coli SMS-3-5 putative amino-acid ABC transporter ATP-binding protein YecC YP_001743326.1 1261703 D 439855 CDS YP_001743327.1 170683439 6145924 1262685..1263407 1 NC_010498.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 1263407 sdiA 6145924 sdiA Escherichia coli SMS-3-5 DNA-binding transcriptional activator SdiA YP_001743327.1 1262685 D 439855 CDS YP_001743328.1 170683059 6142726 complement(1263474..1263698) 1 NC_010498.1 hypothetical protein 1263698 6142726 EcSMS35_1267 Escherichia coli SMS-3-5 hypothetical protein YP_001743328.1 1263474 R 439855 CDS YP_001743329.1 170684231 6147276 1263790..1263918 1 NC_010498.1 hypothetical protein 1263918 6147276 EcSMS35_1268 Escherichia coli SMS-3-5 hypothetical protein YP_001743329.1 1263790 D 439855 CDS YP_001743330.1 170683562 6143532 1264157..1264813 1 NC_010498.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1264813 uvrY 6143532 uvrY Escherichia coli SMS-3-5 response regulator YP_001743330.1 1264157 D 439855 CDS YP_001743331.1 170680797 6142852 1264810..1266642 1 NC_010498.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1266642 uvrC 6142852 uvrC Escherichia coli SMS-3-5 excinuclease ABC subunit C YP_001743331.1 1264810 D 439855 CDS YP_001743332.1 170680427 6144973 1266699..1267247 1 NC_010498.1 identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; phosphatidylglycerophosphate synthetase 1267247 pgsA 6144973 pgsA Escherichia coli SMS-3-5 phosphatidylglycerophosphate synthetase YP_001743332.1 1266699 D 439855 CDS YP_001743333.1 170682664 6143661 1267897..1268562 1 NC_010498.1 identified by match to protein family HMM PF02810; match to protein family HMM TIGR02292; hypothetical protein 1268562 6143661 EcSMS35_1275 Escherichia coli SMS-3-5 hypothetical protein YP_001743333.1 1267897 D 439855 CDS YP_001743334.1 170682363 6146871 complement(1268624..1269835) 1 NC_010498.1 identified by match to protein family HMM PF01490; match to protein family HMM PF03222; match to protein family HMM TIGR00837; tyrosine-specific transport protein 1269835 tyrP 6146871 tyrP Escherichia coli SMS-3-5 tyrosine-specific transport protein YP_001743334.1 1268624 R 439855 CDS YP_001743335.1 170684033 6146562 1270026..1270265 1 NC_010498.1 hypothetical protein 1270265 6146562 EcSMS35_1277 Escherichia coli SMS-3-5 hypothetical protein YP_001743335.1 1270026 D 439855 CDS YP_001743336.1 170682906 6143332 complement(1270303..1270800) 1 NC_010498.1 cytoplasmic iron storage protein; ferritin 1270800 ftnA 6143332 ftnA Escherichia coli SMS-3-5 ferritin YP_001743336.1 1270303 R 439855 CDS YP_001743337.1 170680894 6147120 1270825..1270962 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1270962 6147120 EcSMS35_1279 Escherichia coli SMS-3-5 hypothetical protein YP_001743337.1 1270825 D 439855 CDS YP_001743338.1 170681560 6145072 complement(1270972..1271226) 1 NC_010498.1 putative lipoprotein 1271226 6145072 EcSMS35_1280 Escherichia coli SMS-3-5 putative lipoprotein YP_001743338.1 1270972 R 439855 CDS YP_001743339.1 170680122 6145745 complement(1271501..1271647) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1271647 6145745 EcSMS35_1281 Escherichia coli SMS-3-5 hypothetical protein YP_001743339.1 1271501 R 439855 CDS YP_001743340.1 170680192 6144287 1271759..1272010 1 NC_010498.1 identified by similarity to GB:ABB65745.1; hypothetical protein 1272010 6144287 EcSMS35_1282 Escherichia coli SMS-3-5 hypothetical protein YP_001743340.1 1271759 D 439855 CDS YP_001743341.1 170682855 6144358 complement(1272089..1272592) 1 NC_010498.1 identified by match to protein family HMM PF00210; ferritin family protein 1272592 6144358 EcSMS35_1283 Escherichia coli SMS-3-5 ferritin family protein YP_001743341.1 1272089 R 439855 CDS YP_001743342.1 170683541 6147068 1272741..1272890 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1272890 6147068 EcSMS35_1284 Escherichia coli SMS-3-5 hypothetical protein YP_001743342.1 1272741 D 439855 CDS YP_001743343.1 170680933 6142831 1273388..1274377 1 NC_010498.1 identified by match to protein family HMM PF00532; L-arabinose ABC transporter periplasmic L-arabinose-binding protein 1274377 araF 6142831 araF Escherichia coli SMS-3-5 L-arabinose ABC transporter periplasmic L-arabinose-binding protein YP_001743343.1 1273388 D 439855 CDS YP_001743344.1 170682274 6145114 1274447..1275961 1 NC_010498.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1275961 araG 6145114 araG Escherichia coli SMS-3-5 L-arabinose transporter ATP-binding protein YP_001743344.1 1274447 D 439855 CDS YP_001743345.1 170680269 6146473 1275976..1276962 1 NC_010498.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1276962 araH 6146473 araH Escherichia coli SMS-3-5 L-arabinose transporter permease YP_001743345.1 1275976 D 439855 CDS YP_001743346.1 170679699 6144436 1277129..1277929 1 NC_010498.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1277929 otsB 6144436 otsB Escherichia coli SMS-3-5 trehalose-6-phosphate phosphatase YP_001743346.1 1277129 D 439855 CDS YP_001743347.1 170683748 6143857 1277904..1279328 1 NC_010498.1 identified by match to protein family HMM PF00982; match to protein family HMM TIGR02400; trehalose-6-phosphate synthase 1279328 otsA 6143857 otsA Escherichia coli SMS-3-5 trehalose-6-phosphate synthase YP_001743347.1 1277904 D 439855 CDS YP_001743348.1 170684295 6143040 complement(1279335..1279763) 1 NC_010498.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 1279763 uspC 6143040 uspC Escherichia coli SMS-3-5 universal stress protein UspC YP_001743348.1 1279335 R 439855 CDS YP_001743349.1 170682717 6143597 1280427..1280543 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1280543 6143597 EcSMS35_1291 Escherichia coli SMS-3-5 hypothetical protein YP_001743349.1 1280427 D 439855 CDS YP_001743350.1 170682029 6146925 1280543..1280893 1 NC_010498.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1280893 flhD 6146925 flhD Escherichia coli SMS-3-5 transcriptional activator FlhD YP_001743350.1 1280543 D 439855 CDS YP_001743351.1 170681713 6146226 1280896..1281474 1 NC_010498.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1281474 flhC 6146226 flhC Escherichia coli SMS-3-5 transcriptional activator FlhC YP_001743351.1 1280896 D 439855 CDS YP_001743352.1 170681052 6145901 1281601..1282488 1 NC_010498.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1282488 motA 6145901 motA Escherichia coli SMS-3-5 flagellar motor protein MotA YP_001743352.1 1281601 D 439855 CDS YP_001743353.1 170684155 6145233 1282485..1283411 1 NC_010498.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1283411 motB 6145233 motB Escherichia coli SMS-3-5 flagellar motor protein MotB YP_001743353.1 1282485 D 439855 CDS YP_001743354.1 170683477 6143455 1283422..1285380 1 NC_010498.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1285380 cheA 6143455 cheA Escherichia coli SMS-3-5 chemotaxis protein CheA YP_001743354.1 1283422 D 439855 CDS YP_001743355.1 170681993 6142766 1285401..1285904 1 NC_010498.1 identified by match to protein family HMM PF01584; purine-binding chemotaxis protein 1285904 cheW 6142766 cheW Escherichia coli SMS-3-5 purine-binding chemotaxis protein YP_001743355.1 1285401 D 439855 CDS YP_001743356.1 170680418 6146189 1286049..1287710 1 NC_010498.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein II 1287710 tar 6146189 tar Escherichia coli SMS-3-5 methyl-accepting chemotaxis protein II YP_001743356.1 1286049 D 439855 CDS YP_001743357.1 170679775 6144587 1287756..1289357 1 NC_010498.1 mediates taxis toward dipeptides; methyl-accepting protein IV 1289357 tap 6144587 tap Escherichia coli SMS-3-5 methyl-accepting protein IV YP_001743357.1 1287756 D 439855 CDS YP_001743358.1 170683512 6143934 1289376..1290236 1 NC_010498.1 methylates the MCP; chemotaxis methyltransferase CheR 1290236 cheR 6143934 cheR Escherichia coli SMS-3-5 chemotaxis methyltransferase CheR YP_001743358.1 1289376 D 439855 CDS YP_001743359.1 170683043 6142801 1290239..1291288 1 NC_010498.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1291288 cheB 6142801 cheB Escherichia coli SMS-3-5 chemotaxis-specific methylesterase YP_001743359.1 1290239 D 439855 CDS YP_001743360.1 170682516 6147259 1291303..1291692 1 NC_010498.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1291692 cheY 6147259 cheY Escherichia coli SMS-3-5 chemotaxis regulatory protein CheY YP_001743360.1 1291303 D 439855 CDS YP_001743361.1 170680812 6146716 1291703..1292347 1 NC_010498.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1292347 cheZ 6146716 cheZ Escherichia coli SMS-3-5 chemotaxis regulator CheZ YP_001743361.1 1291703 D 439855 CDS YP_001743362.1 170681340 6144988 complement(1292435..1293187) 1 NC_010498.1 identified by similarity to GB:ABA77767.1; hypothetical protein 1293187 6144988 EcSMS35_1304 Escherichia coli SMS-3-5 hypothetical protein YP_001743362.1 1292435 R 439855 CDS YP_001743363.1 170684108 6145524 complement(1293156..1294664) 1 NC_010498.1 putative deoxyguanosinetriphosphate triphosphohydrolase 1294664 6145524 EcSMS35_1305 Escherichia coli SMS-3-5 putative deoxyguanosinetriphosphate triphosphohydrolase YP_001743363.1 1293156 R 439855 CDS YP_001743364.1 170680321 6143408 complement(1294746..1294868) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1294868 6143408 EcSMS35_1306 Escherichia coli SMS-3-5 hypothetical protein YP_001743364.1 1294746 R 439855 CDS YP_001743365.1 170683078 6144489 1294901..1296049 1 NC_010498.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1296049 flhB 6144489 flhB Escherichia coli SMS-3-5 flagellar biosynthesis protein FlhB YP_001743365.1 1294901 D 439855 CDS YP_001743366.1 170682236 6147295 1296042..1298120 1 NC_010498.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 1298120 flhA 6147295 flhA Escherichia coli SMS-3-5 flagellar biosynthesis protein FlhA YP_001743366.1 1296042 D 439855 CDS YP_001743367.1 170682917 6146435 1298120..1298512 1 NC_010498.1 identified by match to protein family HMM PF06366; flagellar protein FlhE 1298512 flhE 6146435 flhE Escherichia coli SMS-3-5 flagellar protein FlhE YP_001743367.1 1298120 D 439855 CDS YP_001743368.1 170683284 6147131 complement(1298565..1300298) 1 NC_010498.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1300298 argS 6147131 argS Escherichia coli SMS-3-5 arginyl-tRNA synthetase YP_001743368.1 1298565 R 439855 CDS YP_001743369.1 170680704 6147510 1300508..1301080 1 NC_010498.1 identified by match to protein family HMM PF06185; hypothetical protein 1301080 6147510 EcSMS35_1311 Escherichia coli SMS-3-5 hypothetical protein YP_001743369.1 1300508 D 439855 CDS YP_001743370.1 170681209 6144879 1301094..1301840 1 NC_010498.1 identified by match to protein family HMM PF03932; copper homeostasis protein CutC 1301840 cutC 6144879 cutC Escherichia coli SMS-3-5 copper homeostasis protein CutC YP_001743370.1 1301094 D 439855 CDS YP_001743371.1 170682004 6145393 1302228..1303328 1 NC_010498.1 identified by match to protein family HMM PF03264; trimethylamine N-oxide reductase III, c-type cytochrome subunit TorY 1303328 torY 6145393 torY Escherichia coli SMS-3-5 trimethylamine N-oxide reductase III, c-type cytochrome subunit TorY YP_001743371.1 1302228 D 439855 CDS YP_001743372.1 170682533 6146201 1303353..1305782 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; trimethylamine N-oxide reductase III, subunit TorZ 1305782 torZ 6146201 torZ Escherichia coli SMS-3-5 trimethylamine N-oxide reductase III, subunit TorZ YP_001743372.1 1303353 D 439855 CDS YP_001743373.1 170683171 6146734 complement(1305817..1306788) 1 NC_010498.1 identified by match to protein family HMM PF08003; match to protein family HMM PF08241; match to protein family HMM TIGR00452; putative methyltransferase 1306788 6146734 EcSMS35_1315 Escherichia coli SMS-3-5 putative methyltransferase YP_001743373.1 1305817 R 439855 CDS YP_001743374.1 170684168 6147391 complement(1306785..1307528) 1 NC_010498.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00740; putative methyltransferase 1307528 6147391 EcSMS35_1316 Escherichia coli SMS-3-5 putative methyltransferase YP_001743374.1 1306785 R 439855 CDS YP_001743375.1 170680079 6143469 complement(1307569..1307964) 1 NC_010498.1 putative inner membrane protein 1307964 6143469 EcSMS35_1317 Escherichia coli SMS-3-5 putative inner membrane protein YP_001743375.1 1307569 R 439855 CDS YP_001743376.1 170681050 6144243 complement(1308017..1308835) 1 NC_010498.1 identified by match to protein family HMM PF01904; hypothetical protein 1308835 6144243 EcSMS35_1318 Escherichia coli SMS-3-5 hypothetical protein YP_001743376.1 1308017 R 439855 CDS YP_001743377.1 170681711 6145231 complement(1308832..1309398) 1 NC_010498.1 identified by match to protein family HMM PF00857; hypothetical protein 1309398 6145231 EcSMS35_1319 Escherichia coli SMS-3-5 hypothetical protein YP_001743377.1 1308832 R 439855 CDS YP_001743378.1 170682211 6145898 1309708..1311480 1 NC_010498.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1311480 aspS 6145898 aspS Escherichia coli SMS-3-5 aspartyl-tRNA synthetase YP_001743378.1 1309708 D 439855 CDS YP_001743379.1 170682556 6146410 1311482..1311925 1 NC_010498.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1311925 ntpA 6146410 ntpA Escherichia coli SMS-3-5 dATP pyrophosphohydrolase YP_001743379.1 1311482 D 439855 CDS YP_001743380.1 170683235 6146759 1311954..1312694 1 NC_010498.1 yebC; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1312694 6146759 EcSMS35_1322 Escherichia coli SMS-3-5 hypothetical protein YP_001743380.1 1311954 D 439855 CDS YP_001743381.1 170682372 6147456 1312729..1313250 1 NC_010498.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1313250 ruvC 6147456 ruvC Escherichia coli SMS-3-5 Holliday junction resolvase YP_001743381.1 1312729 D 439855 CDS YP_001743382.1 170680674 6146571 complement(1313252..1313854) 1 NC_010498.1 identified by match to protein family HMM PF06520; hypothetical protein 1313854 6146571 EcSMS35_1324 Escherichia coli SMS-3-5 hypothetical protein YP_001743382.1 1313252 R 439855 CDS YP_001743383.1 170683558 6144849 1314129..1314740 1 NC_010498.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1314740 ruvA 6144849 ruvA Escherichia coli SMS-3-5 Holliday junction DNA helicase RuvA YP_001743383.1 1314129 D 439855 CDS YP_001743384.1 170681518 6142848 1314749..1315759 1 NC_010498.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1315759 ruvB 6142848 ruvB Escherichia coli SMS-3-5 Holliday junction DNA helicase RuvB YP_001743384.1 1314749 D 439855 CDS YP_001743385.1 170679836 6145703 complement(1315906..1316691) 1 NC_010498.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1316691 znuB 6145703 znuB Escherichia coli SMS-3-5 high-affinity zinc transporter membrane component YP_001743385.1 1315906 R 439855 CDS YP_001743386.1 170682668 6143998 complement(1316688..1317443) 1 NC_010498.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1317443 znuC 6143998 znuC Escherichia coli SMS-3-5 high-affinity zinc transporter ATPase YP_001743386.1 1316688 R 439855 CDS YP_001743387.1 170681737 6146875 1317396..1318454 1 NC_010498.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1318454 znuA 6146875 znuA Escherichia coli SMS-3-5 high-affinity zinc transporter periplasmic component YP_001743387.1 1317396 D 439855 CDS YP_001743388.1 170682487 6145926 1318470..1319792 1 NC_010498.1 identified by match to protein family HMM PF01476; match to protein family HMM PF01551; match to protein family HMM PF04225; match to protein family HMM PF08525; hypothetical protein 1319792 6145926 EcSMS35_1330 Escherichia coli SMS-3-5 hypothetical protein YP_001743388.1 1318470 D 439855 CDS YP_001743389.1 170680587 6146686 1319911..1320882 1 NC_010498.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1320882 msbB 6146686 msbB Escherichia coli SMS-3-5 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_001743389.1 1319911 D 439855 CDS YP_001743390.1 170680822 6144758 complement(1321014..1322456) 1 NC_010498.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1322456 pykA 6144758 pykA Escherichia coli SMS-3-5 pyruvate kinase YP_001743390.1 1321014 R 439855 CDS YP_001743391.1 170683767 6144999 complement(1322584..1323453) 1 NC_010498.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1323453 6144999 EcSMS35_1333 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator HexR YP_001743391.1 1322584 R 439855 CDS YP_001743392.1 170679835 6143059 1323476..1323625 1 NC_010498.1 hypothetical protein 1323625 6143059 EcSMS35_1334 Escherichia coli SMS-3-5 hypothetical protein YP_001743392.1 1323476 D 439855 CDS YP_001743393.1 170683501 6143997 1323791..1325266 1 NC_010498.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1325266 zwf 6143997 zwf Escherichia coli SMS-3-5 glucose-6-phosphate 1-dehydrogenase YP_001743393.1 1323791 D 439855 CDS YP_001743394.1 170684043 6142790 1325501..1327312 1 NC_010498.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1327312 edd 6142790 edd Escherichia coli SMS-3-5 phosphogluconate dehydratase YP_001743394.1 1325501 D 439855 CDS YP_001743395.1 170682566 6143342 1327349..1327990 1 NC_010498.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1327990 eda 6143342 eda Escherichia coli SMS-3-5 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_001743395.1 1327349 D 439855 CDS YP_001743396.1 170684011 6146771 complement(1328046..1329224) 1 NC_010498.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1329224 purT 6146771 purT Escherichia coli SMS-3-5 phosphoribosylglycinamide formyltransferase 2 YP_001743396.1 1328046 R 439855 CDS YP_001743397.1 170679848 6143310 1329358..1329648 1 NC_010498.1 identified by match to protein family HMM PF07130; DNA damage-inducible protein YebG 1329648 6143310 EcSMS35_1339 Escherichia coli SMS-3-5 DNA damage-inducible protein YebG YP_001743397.1 1329358 D 439855 CDS YP_001743398.1 170680374 6144010 1329703..1330071 1 NC_010498.1 secreted protein; unknown function; hypothetical protein 1330071 6144010 EcSMS35_1340 Escherichia coli SMS-3-5 hypothetical protein YP_001743398.1 1329703 D 439855 CDS YP_001743399.1 170681801 6144542 1330388..1331047 1 NC_010498.1 identified by match to protein family HMM PF04391; hypothetical protein 1331047 6144542 EcSMS35_1341 Escherichia coli SMS-3-5 hypothetical protein YP_001743399.1 1330388 D 439855 CDS YP_001743400.1 170682850 6145994 1331254..1333314 1 NC_010498.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1333314 prtB 6145994 prtB Escherichia coli SMS-3-5 protease 2 YP_001743400.1 1331254 D 439855 CDS YP_001743401.1 170681411 6147063 complement(1333311..1333973) 1 NC_010498.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1333973 exoX 6147063 exoX Escherichia coli SMS-3-5 exodeoxyribonuclease X YP_001743401.1 1333311 R 439855 CDS YP_001743402.1 170683686 6145595 complement(1333997..1334653) 1 NC_010498.1 identified by match to protein family HMM PF00795; carbon-nitrogen family hydrolase 1334653 6145595 EcSMS35_1344 Escherichia coli SMS-3-5 carbon-nitrogen family hydrolase YP_001743402.1 1333997 R 439855 CDS YP_001743403.1 170680257 6142978 complement(1334755..1334985) 1 NC_010498.1 identified by match to protein family HMM PF06440; DNA polymerase III subunit theta 1334985 holE 6142978 holE Escherichia coli SMS-3-5 DNA polymerase III subunit theta YP_001743403.1 1334755 R 439855 CDS YP_001743404.1 170680865 6144424 1335124..1335498 1 NC_010498.1 identified by match to protein family HMM PF04234; hypothetical protein 1335498 6144424 EcSMS35_1346 Escherichia coli SMS-3-5 hypothetical protein YP_001743404.1 1335124 D 439855 CDS YP_001743405.1 170682421 6145043 1335502..1336374 1 NC_010498.1 identified by match to protein family HMM PF05425; copper resistance protein D 1336374 6145043 EcSMS35_1347 Escherichia coli SMS-3-5 copper resistance protein D YP_001743405.1 1335502 D 439855 CDS YP_001743406.1 170679629 6146620 1336387..1336728 1 NC_010498.1 hypothetical protein 1336728 6146620 EcSMS35_1348 Escherichia coli SMS-3-5 hypothetical protein YP_001743406.1 1336387 D 439855 CDS YP_001743407.1 170681542 6143786 1337124..1337780 1 NC_010498.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1337780 pphA 6143786 pphA Escherichia coli SMS-3-5 serine/threonine protein phosphatase 1 YP_001743407.1 1337124 D 439855 CDS YP_001743408.1 170680889 6145727 complement(1337781..1337972) 1 NC_010498.1 identified by match to protein family HMM PF07358; hypothetical protein 1337972 6145727 EcSMS35_1350 Escherichia coli SMS-3-5 hypothetical protein YP_001743408.1 1337781 R 439855 CDS YP_001743409.1 170682835 6145067 complement(1338077..1338313) 1 NC_010498.1 identified by match to protein family HMM PF07351; hypothetical protein 1338313 6145067 EcSMS35_1351 Escherichia coli SMS-3-5 hypothetical protein YP_001743409.1 1338077 R 439855 CDS YP_001743410.1 170683942 6147046 complement(1338431..1339876) 1 NC_010498.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1339876 yebU 6147046 yebU Escherichia coli SMS-3-5 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_001743410.1 1338431 R 439855 CDS YP_001743411.1 170684215 6143238 complement(1339950..1342589) 1 NC_010498.1 identified by match to protein family HMM PF02470; mce-related protein 1342589 6143238 EcSMS35_1353 Escherichia coli SMS-3-5 mce-related protein YP_001743411.1 1339950 R 439855 CDS YP_001743412.1 170683557 6143516 complement(1342552..1343790) 1 NC_010498.1 identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155; PqiA family integral membrane protein 1343790 6143516 EcSMS35_1354 Escherichia coli SMS-3-5 PqiA family integral membrane protein YP_001743412.1 1342552 R 439855 CDS YP_001743413.1 170681196 6142847 1343911..1344462 1 NC_010498.1 identified by match to protein family HMM PF01590; GAF domain-containing protein 1344462 6142847 EcSMS35_1355 Escherichia coli SMS-3-5 GAF domain-containing protein YP_001743413.1 1343911 D 439855 CDS YP_001743414.1 170682895 6145380 1344559..1345257 1 NC_010498.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1345257 proQ 6145380 proQ Escherichia coli SMS-3-5 putative solute/DNA competence effector YP_001743414.1 1344559 D 439855 CDS YP_001743415.1 170681936 6147108 1345283..1347325 1 NC_010498.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1347325 prc 6147108 prc Escherichia coli SMS-3-5 carboxy-terminal protease YP_001743415.1 1345283 D 439855 CDS YP_001743416.1 170682375 6146132 1347517..1348398 1 NC_010498.1 putative metalloprotease; heat shock protein HtpX 1348398 6146132 EcSMS35_1358 Escherichia coli SMS-3-5 heat shock protein HtpX YP_001743416.1 1347517 D 439855 CDS YP_001743417.1 170680826 6146574 complement(1348444..1349817) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 1349817 6146574 EcSMS35_1359 Escherichia coli SMS-3-5 major facilitator transporter YP_001743417.1 1348444 R 439855 CDS YP_001743418.1 170681338 6145003 1349994..1350785 1 NC_010498.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339; transcriptional regulator KdgR 1350785 kdgR 6145003 kdgR Escherichia coli SMS-3-5 transcriptional regulator KdgR YP_001743418.1 1349994 D 439855 CDS YP_001743419.1 170683696 6145522 complement(1350929..1351168) 1 NC_010498.1 hypothetical protein 1351168 6145522 EcSMS35_1361 Escherichia coli SMS-3-5 hypothetical protein YP_001743419.1 1350929 R 439855 CDS YP_001743420.1 170679830 6142988 1351327..1351470 1 NC_010498.1 hypothetical protein 1351470 6142988 EcSMS35_1362 Escherichia coli SMS-3-5 hypothetical protein YP_001743420.1 1351327 D 439855 CDS YP_001743421.1 170682701 6143992 1351545..1351832 1 NC_010498.1 hypothetical protein 1351832 6143992 EcSMS35_1363 Escherichia coli SMS-3-5 hypothetical protein YP_001743421.1 1351545 D 439855 CDS YP_001743422.1 170683542 6146909 1352502..1352645 1 NC_010498.1 hypothetical protein 1352645 6146909 EcSMS35_1364 Escherichia coli SMS-3-5 hypothetical protein YP_001743422.1 1352502 D 439855 CDS YP_001743423.1 170682897 6142832 1352658..1352867 1 NC_010498.1 identified by match to protein family HMM PF00313; cold shock-like protein CspC 1352867 cspC 6142832 cspC Escherichia coli SMS-3-5 cold shock-like protein CspC YP_001743423.1 1352658 D 439855 CDS YP_001743424.1 170683757 6147110 1353033..1353842 1 NC_010498.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1353842 rrmA 6147110 rrmA Escherichia coli SMS-3-5 23S rRNA methyltransferase A YP_001743424.1 1353033 D 439855 CDS YP_001743425.1 170683257 6143049 complement(1353839..1354405) 1 NC_010498.1 membrane protein YebN; hypothetical protein 1354405 6143049 EcSMS35_1366 Escherichia coli SMS-3-5 hypothetical protein YP_001743425.1 1353839 R 439855 CDS YP_001743426.1 170682842 6147480 complement(1354834..1355292) 1 NC_010498.1 identified by match to protein family HMM PF06173; hypothetical protein 1355292 6147480 EcSMS35_1368 Escherichia coli SMS-3-5 hypothetical protein YP_001743426.1 1354834 R 439855 CDS YP_001743427.1 170680039 6147053 complement(1355347..1356198) 1 NC_010498.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1356198 manZ 6147053 manZ Escherichia coli SMS-3-5 PTS system mannose-specific transporter subunit IID YP_001743427.1 1355347 R 439855 CDS YP_001743428.1 170683840 6144202 complement(1356211..1357011) 1 NC_010498.1 identified by match to protein family HMM PF03609; match to protein family HMM TIGR00822; PTS system, mannose-specific IIC component 1357011 manY 6144202 manY Escherichia coli SMS-3-5 PTS system, mannose-specific IIC component YP_001743428.1 1356211 R 439855 CDS YP_001743429.1 170680281 6143134 complement(1357074..1358045) 1 NC_010498.1 identified by match to protein family HMM PF03610; match to protein family HMM PF03830; match to protein family HMM TIGR00824; match to protein family HMM TIGR00854; PTS system, mannose-specific IIAB component 1358045 manX 6143134 manX Escherichia coli SMS-3-5 PTS system, mannose-specific IIAB component YP_001743429.1 1357074 R 439855 CDS YP_001743430.1 170679631 6144448 1358508..1360064 1 NC_010498.1 identified by match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741; TerC family/CBS/transporter associated domain-containing protein 1360064 6144448 EcSMS35_1372 Escherichia coli SMS-3-5 TerC family/CBS/transporter associated domain-containing protein YP_001743430.1 1358508 D 439855 CDS YP_001743431.1 170681526 6143788 complement(1360068..1361666) 1 NC_010498.1 identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 1361666 6143788 EcSMS35_1373 Escherichia coli SMS-3-5 cyclic diguanylate phosphodiesterase domain-containing protein YP_001743431.1 1360068 R 439855 CDS YP_001743432.1 170681757 6145711 complement(1361797..1363161) 1 NC_010498.1 identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase 1 1363161 sdaA 6145711 sdaA Escherichia coli SMS-3-5 L-serine ammonia-lyase 1 YP_001743432.1 1361797 R 439855 CDS YP_001743433.1 170680320 6145948 complement(1363345..1363923) 1 NC_010498.1 identified by match to protein family HMM PF00293; hypothetical protein 1363923 6145948 EcSMS35_1375 Escherichia coli SMS-3-5 hypothetical protein YP_001743433.1 1363345 R 439855 CDS YP_001743434.1 170679636 6144488 complement(1363927..1365288) 1 NC_010498.1 identified by match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553; aminodeoxychorismate synthase 1365288 pabB 6144488 pabB Escherichia coli SMS-3-5 aminodeoxychorismate synthase YP_001743434.1 1363927 R 439855 CDS YP_001743435.1 170681374 6143793 1365362..1365541 1 NC_010498.1 identified by match to protein family HMM PF03701; hypothetical protein 1365541 6143793 EcSMS35_1377 Escherichia coli SMS-3-5 hypothetical protein YP_001743435.1 1365362 D 439855 CDS YP_001743436.1 170681162 6145558 complement(1365661..1365960) 1 NC_010498.1 identified by match to protein family HMM PF08986; hypothetical protein 1365960 6145558 EcSMS35_1378 Escherichia coli SMS-3-5 hypothetical protein YP_001743436.1 1365661 R 439855 CDS YP_001743437.1 170680959 6145346 complement(1366382..1366726) 1 NC_010498.1 identified by match to protein family HMM PF01042; endoribonuclease L-PSP family protein 1366726 6145346 EcSMS35_1379 Escherichia coli SMS-3-5 endoribonuclease L-PSP family protein YP_001743437.1 1366382 R 439855 CDS YP_001743438.1 170682824 6145140 1366858..1368768 1 NC_010498.1 hypothetical protein 1368768 6145140 EcSMS35_1380 Escherichia coli SMS-3-5 hypothetical protein YP_001743438.1 1366858 D 439855 CDS YP_001743439.1 170683819 6147035 1368826..1369521 1 NC_010498.1 identified by match to protein family HMM PF00814; glycoprotease family protein 1369521 6147035 EcSMS35_1381 Escherichia coli SMS-3-5 glycoprotease family protein YP_001743439.1 1368826 D 439855 CDS YP_001743440.1 170683154 6143113 1369560..1370141 1 NC_010498.1 identified by match to protein family HMM PF03843; match to protein family HMM TIGR00752; outer membrane protein Slp 1370141 slp 6143113 slp Escherichia coli SMS-3-5 outer membrane protein Slp YP_001743440.1 1369560 D 439855 CDS YP_001743441.1 170680693 6147374 1370346..1372031 1 NC_010498.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1372031 fadD 6147374 fadD Escherichia coli SMS-3-5 long-chain-fatty-acid--CoA ligase YP_001743441.1 1370346 D 439855 CDS YP_001743442.1 170680016 6144868 1372101..1373228 1 NC_010498.1 identified by match to protein family HMM PF00570; match to protein family HMM PF01612; match to protein family HMM TIGR01388; ribonuclease D 1373228 rnd 6144868 rnd Escherichia coli SMS-3-5 ribonuclease D YP_001743442.1 1372101 D 439855 CDS YP_001743443.1 170680439 6144179 complement(1373275..1374240) 1 NC_010498.1 identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; oxidoreductase, FAD/NAD-binding/iron-sulfur cluster binding protein 1374240 6144179 EcSMS35_1385 Escherichia coli SMS-3-5 oxidoreductase, FAD/NAD-binding/iron-sulfur cluster binding protein YP_001743443.1 1373275 R 439855 CDS YP_001743444.1 170679804 6144608 complement(1374296..1375420) 1 NC_010498.1 identified by match to protein family HMM PF00355; Rieske (2Fe-2S) domain-containing protein 1375420 6144608 EcSMS35_1386 Escherichia coli SMS-3-5 Rieske (2Fe-2S) domain-containing protein YP_001743444.1 1374296 R 439855 CDS YP_001743445.1 170681413 6143964 complement(1375452..1377062) 1 NC_010498.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter 1377062 6143964 EcSMS35_1387 Escherichia coli SMS-3-5 putative transporter YP_001743445.1 1375452 R 439855 CDS YP_001743446.1 170679663 6145597 complement(1377313..1378398) 1 NC_010498.1 identified by match to protein family HMM PF00180; match to protein family HMM TIGR02089; tartrate dehydrogenase/decarboxylase 1378398 ttuC 6145597 ttuC Escherichia coli SMS-3-5 tartrate dehydrogenase/decarboxylase YP_001743446.1 1377313 R 439855 CDS YP_001743447.1 170681592 6143821 1378501..1379424 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1379424 6143821 EcSMS35_1389 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743447.1 1378501 D 439855 CDS YP_001743448.1 170680974 6145777 1379551..1380189 1 NC_010498.1 identified by match to protein family HMM PF01810; leucine export protein LeuE 1380189 6145777 EcSMS35_1390 Escherichia coli SMS-3-5 leucine export protein LeuE YP_001743448.1 1379551 D 439855 CDS YP_001743449.1 170682861 6145155 complement(1380257..1380391) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1380391 6145155 EcSMS35_1391 Escherichia coli SMS-3-5 hypothetical protein YP_001743449.1 1380257 R 439855 CDS YP_001743450.1 170682328 6147074 1380362..1380721 1 NC_010498.1 identified by match to protein family HMM PF09313; hypothetical protein 1380721 6147074 EcSMS35_1392 Escherichia coli SMS-3-5 hypothetical protein YP_001743450.1 1380362 D 439855 CDS YP_001743451.1 170684193 6146527 1380725..1380907 1 NC_010498.1 identified by match to protein family HMM PF08956; hypothetical protein 1380907 6146527 EcSMS35_1393 Escherichia coli SMS-3-5 hypothetical protein YP_001743451.1 1380725 D 439855 CDS YP_001743452.1 170683640 6143494 1380924..1381043 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1381043 6143494 EcSMS35_1394 Escherichia coli SMS-3-5 hypothetical protein YP_001743452.1 1380924 D 439855 CDS YP_001743453.1 170684204 6142932 1381055..1381303 1 NC_010498.1 identified by match to protein family HMM PF04226; hypothetical protein 1381303 6142932 EcSMS35_1395 Escherichia coli SMS-3-5 hypothetical protein YP_001743453.1 1381055 D 439855 CDS YP_001743454.1 170683641 6143505 complement(1381439..1381552) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1381552 6143505 EcSMS35_1396 Escherichia coli SMS-3-5 hypothetical protein YP_001743454.1 1381439 R 439855 CDS YP_001743455.1 170679654 6142933 complement(1381570..1382595) 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM PF01590; match to protein family HMM TIGR00254; GAF domain/diguanylate cyclase domain-containing protein 1382595 6142933 EcSMS35_1397 Escherichia coli SMS-3-5 GAF domain/diguanylate cyclase domain-containing protein YP_001743455.1 1381570 R 439855 CDS YP_001743456.1 170679933 6143811 1382778..1383032 1 NC_010498.1 identified by match to protein family HMM PF03891; putative lipoprotein 1383032 6143811 EcSMS35_1398 Escherichia coli SMS-3-5 putative lipoprotein YP_001743456.1 1382778 D 439855 CDS YP_001743457.1 170681477 6144095 complement(1383054..1383401) 1 NC_010498.1 identified by match to protein family HMM PF04343; hypothetical protein 1383401 6144095 EcSMS35_1399 Escherichia coli SMS-3-5 hypothetical protein YP_001743457.1 1383054 R 439855 CDS YP_001743458.1 170683088 6145662 complement(1383456..1384637) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00896; inner membrane transport protein yeaN 1384637 yeaN 6145662 yeaN Escherichia coli SMS-3-5 inner membrane transport protein yeaN YP_001743458.1 1383456 R 439855 CDS YP_001743459.1 170684028 6147305 1384746..1385555 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 1385555 6147305 EcSMS35_1402 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001743459.1 1384746 D 439855 CDS YP_001743460.1 170682574 6143327 complement(1385512..1385958) 1 NC_010498.1 identified by match to protein family HMM PF04284; hypothetical protein 1385958 6143327 EcSMS35_1401 Escherichia coli SMS-3-5 hypothetical protein YP_001743460.1 1385512 R 439855 CDS YP_001743461.1 170683511 6146779 1386080..1386232 1 NC_010498.1 hypothetical protein 1386232 6146779 EcSMS35_1403 Escherichia coli SMS-3-5 hypothetical protein YP_001743461.1 1386080 D 439855 CDS YP_001743462.1 170684068 6142800 complement(1386233..1386736) 1 NC_010498.1 identified by match to protein family HMM PF04073; YbaK/prolyl-tRNA synthetase-associated domain-containing protein 1386736 6142800 EcSMS35_1404 Escherichia coli SMS-3-5 YbaK/prolyl-tRNA synthetase-associated domain-containing protein YP_001743462.1 1386233 R 439855 CDS YP_001743463.1 170683497 6143368 complement(1386779..1388269) 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1388269 6143368 EcSMS35_1405 Escherichia coli SMS-3-5 diguanylate cyclase YP_001743463.1 1386779 R 439855 CDS YP_001743464.1 170680353 6142786 complement(1388450..1389784) 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1389784 6142786 EcSMS35_1406 Escherichia coli SMS-3-5 diguanylate cyclase YP_001743464.1 1388450 R 439855 CDS YP_001743465.1 170679771 6144521 complement(1390072..1391355) 1 NC_010498.1 identified by match to protein family HMM PF04285; hypothetical protein 1391355 6144521 EcSMS35_1407 Escherichia coli SMS-3-5 hypothetical protein YP_001743465.1 1390072 R 439855 CDS YP_001743466.1 170684310 6143930 complement(1391468..1393402) 1 NC_010498.1 identified by match to protein family HMM PF06798; match to protein family HMM PF08298; serine kinase family protein 1393402 6143930 EcSMS35_1408 Escherichia coli SMS-3-5 serine kinase family protein YP_001743466.1 1391468 R 439855 CDS YP_001743467.1 170682310 6143612 1393838..1394584 1 NC_010498.1 identified by match to protein family HMM PF06629; MltA-interacting protein MipA 1394584 mipA 6143612 mipA Escherichia coli SMS-3-5 MltA-interacting protein MipA YP_001743467.1 1393838 D 439855 CDS YP_001743468.1 170683077 6146509 1394674..1395528 1 NC_010498.1 identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 1395528 6146509 EcSMS35_1410 Escherichia coli SMS-3-5 aldo/keto reductase family oxidoreductase YP_001743468.1 1394674 D 439855 CDS YP_001743469.1 170681442 6147294 complement(1395579..1396463) 1 NC_010498.1 identified by match to protein family HMM PF01263; aldose 1-epimerase family protein 1396463 6147294 EcSMS35_1411 Escherichia coli SMS-3-5 aldose 1-epimerase family protein YP_001743469.1 1395579 R 439855 CDS YP_001743470.1 170679626 6145627 complement(1396547..1397542) 1 NC_010498.1 identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; giyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1397542 gapA 6145627 gapA Escherichia coli SMS-3-5 giyceraldehyde-3-phosphate dehydrogenase (phosphorylating) YP_001743470.1 1396547 R 439855 CDS YP_001743471.1 170680440 6143783 1397884..1398297 1 NC_010498.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1398297 msrB 6143783 msrB Escherichia coli SMS-3-5 methionine sulfoxide reductase B YP_001743471.1 1397884 D 439855 CDS YP_001743472.1 170683495 6144609 1398339..1398611 1 NC_010498.1 identified by match to protein family HMM PF07023; hypothetical protein 1398611 6144609 EcSMS35_1414 Escherichia coli SMS-3-5 hypothetical protein YP_001743472.1 1398339 D 439855 CDS YP_001743473.1 170684023 6142784 1398981..1400057 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 1400057 6142784 EcSMS35_1415 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001743473.1 1398981 D 439855 CDS YP_001743474.1 170683522 6143322 1400084..1401463 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 1401463 ydjK 6143322 ydjK Escherichia coli SMS-3-5 major facilitator family transporter YP_001743474.1 1400084 D 439855 CDS YP_001743475.1 170684066 6142812 1401480..1402523 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; sorbitol dehydrogenase 1402523 gutB 6142812 gutB Escherichia coli SMS-3-5 sorbitol dehydrogenase YP_001743475.1 1401480 D 439855 CDS YP_001743476.1 170681361 6143366 1402544..1403380 1 NC_010498.1 identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; fructose-bisphosphate aldolase 1403380 6143366 EcSMS35_1418 Escherichia coli SMS-3-5 fructose-bisphosphate aldolase YP_001743476.1 1402544 D 439855 CDS YP_001743477.1 170679811 6145545 1403385..1404332 1 NC_010498.1 identified by match to protein family HMM PF00294; PfkB family kinase 1404332 6145545 EcSMS35_1419 Escherichia coli SMS-3-5 PfkB family kinase YP_001743477.1 1403385 D 439855 CDS YP_001743478.1 170680323 6143972 1404342..1405322 1 NC_010498.1 identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 1405322 6143972 EcSMS35_1420 Escherichia coli SMS-3-5 aldo/keto reductase family oxidoreductase YP_001743478.1 1404342 D 439855 CDS YP_001743479.1 170680519 6144491 1405459..1406217 1 NC_010498.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator 1406217 6144491 EcSMS35_1421 Escherichia coli SMS-3-5 DeoR family transcriptional regulator YP_001743479.1 1405459 D 439855 CDS YP_001743480.1 170683543 6144689 1406334..1407692 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 1407692 ydjE 6144689 ydjE Escherichia coli SMS-3-5 major facilitator family transporter YP_001743480.1 1406334 D 439855 CDS YP_001743481.1 170683713 6142833 complement(1407785..1408426) 1 NC_010498.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1408426 pncA 6142833 pncA Escherichia coli SMS-3-5 nicotinamidase/pyrazinamidase YP_001743481.1 1407785 R 439855 CDS YP_001743482.1 170682503 6143005 complement(1408437..1409453) 1 NC_010498.1 converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1409453 ansA 6143005 ansA Escherichia coli SMS-3-5 cytoplasmic asparaginase I YP_001743482.1 1408437 R 439855 CDS YP_001743483.1 170683467 6146703 complement(1409620..1411488) 1 NC_010498.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1411488 sppA 6146703 sppA Escherichia coli SMS-3-5 protease 4 YP_001743483.1 1409620 R 439855 CDS YP_001743484.1 170682220 6142756 1411637..1412188 1 NC_010498.1 identified by match to protein family HMM PF00881; hypothetical protein 1412188 6142756 EcSMS35_1426 Escherichia coli SMS-3-5 hypothetical protein YP_001743484.1 1411637 D 439855 CDS YP_001743485.1 170681972 6146419 1412305..1413348 1 NC_010498.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1413348 selD 6146419 selD Escherichia coli SMS-3-5 selenophosphate synthetase YP_001743485.1 1412305 D 439855 CDS YP_001743486.1 170682846 6146168 1413353..1415308 1 NC_010498.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1415308 topB 6146168 topB Escherichia coli SMS-3-5 DNA topoisomerase III YP_001743486.1 1413353 D 439855 CDS YP_001743487.1 170681354 6147058 complement(1415385..1416728) 1 NC_010498.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1416728 gdhA 6147058 gdhA Escherichia coli SMS-3-5 glutamate dehydrogenase YP_001743487.1 1415385 R 439855 CDS YP_001743488.1 170683600 6145538 1416964..1417236 1 NC_010498.1 identified by match to protein family HMM PF07383; hypothetical protein 1417236 6145538 EcSMS35_1431 Escherichia coli SMS-3-5 hypothetical protein YP_001743488.1 1416964 D 439855 CDS YP_001743489.1 170679665 6142890 complement(1417202..1417609) 1 NC_010498.1 identified by match to protein family HMM PF00293; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1417609 nudG 6142890 nudG Escherichia coli SMS-3-5 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_001743489.1 1417202 R 439855 CDS YP_001743490.1 170684299 6143823 1417696..1418316 1 NC_010498.1 identified by match to protein family HMM PF01066; CDP-alcohol phosphatidyltransferase family protein 1418316 6143823 EcSMS35_1432 Escherichia coli SMS-3-5 CDP-alcohol phosphatidyltransferase family protein YP_001743490.1 1417696 D 439855 CDS YP_001743491.1 170684124 6143601 complement(1418325..1419632) 1 NC_010498.1 rhodanese-like domain-containing protein 1419632 6143601 EcSMS35_1433 Escherichia coli SMS-3-5 rhodanese-like domain-containing protein YP_001743491.1 1418325 R 439855 CDS YP_001743492.1 170682394 6143424 complement(1419699..1420352) 1 NC_010498.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1420352 6143424 EcSMS35_1434 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001743492.1 1419699 R 439855 CDS YP_001743493.1 170682828 6146593 complement(1420352..1421887) 1 NC_010498.1 ABC transporter permease 1421887 ynjC 6146593 ynjC Escherichia coli SMS-3-5 ABC transporter permease YP_001743493.1 1420352 R 439855 CDS YP_001743494.1 170681072 6147039 complement(1421860..1423026) 1 NC_010498.1 putative ABC transporter solute-binding protein 1423026 6147039 EcSMS35_1436 Escherichia coli SMS-3-5 putative ABC transporter solute-binding protein YP_001743494.1 1421860 R 439855 CDS YP_001743495.1 170682311 6145254 complement(1423036..1423584) 1 NC_010498.1 identified by match to protein family HMM PF02627; carboxymuconolactone decarboxylase family protein 1423584 6145254 EcSMS35_1437 Escherichia coli SMS-3-5 carboxymuconolactone decarboxylase family protein YP_001743495.1 1423036 R 439855 CDS YP_001743496.1 170682770 6146510 complement(1423584..1424291) 1 NC_010498.1 identified by match to protein family HMM PF09335; hypothetical protein 1424291 6146510 EcSMS35_1438 Escherichia coli SMS-3-5 hypothetical protein YP_001743496.1 1423584 R 439855 CDS YP_001743497.1 170682069 6146979 complement(1424306..1424983) 1 NC_010498.1 hypothetical protein 1424983 6146979 EcSMS35_1439 Escherichia coli SMS-3-5 hypothetical protein YP_001743497.1 1424306 R 439855 CDS YP_001743498.1 170683801 6146266 complement(1424988..1425698) 1 NC_010498.1 identified by match to protein family HMM PF09335; hypothetical protein 1425698 6146266 EcSMS35_1440 Escherichia coli SMS-3-5 hypothetical protein YP_001743498.1 1424988 R 439855 CDS YP_001743499.1 170683141 6143095 complement(1425865..1426671) 1 NC_010498.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1426671 xth 6143095 xth Escherichia coli SMS-3-5 exonuclease III YP_001743499.1 1425865 R 439855 CDS YP_001743500.1 170680684 6147361 complement(1426684..1426854) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1426854 6147361 EcSMS35_1442 Escherichia coli SMS-3-5 hypothetical protein YP_001743500.1 1426684 R 439855 CDS YP_001743501.1 170680032 6144859 1427117..1428337 1 NC_010498.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1428337 astC 6144859 astC Escherichia coli SMS-3-5 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_001743501.1 1427117 D 439855 CDS YP_001743502.1 170681730 6144195 1428334..1429368 1 NC_010498.1 identified by match to protein family HMM PF04958; match to protein family HMM TIGR03243; match to protein family HMM TIGR03244; arginine succinyltransferase 1429368 astA 6144195 astA Escherichia coli SMS-3-5 arginine succinyltransferase YP_001743502.1 1428334 D 439855 CDS YP_001743503.1 170679694 6145919 1429365..1430843 1 NC_010498.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1430843 astD 6145919 astD Escherichia coli SMS-3-5 succinylglutamic semialdehyde dehydrogenase YP_001743503.1 1429365 D 439855 CDS YP_001743504.1 170681484 6143852 1430840..1432183 1 NC_010498.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1432183 astB 6143852 astB Escherichia coli SMS-3-5 succinylarginine dihydrolase YP_001743504.1 1430840 D 439855 CDS YP_001743505.1 170681014 6145669 1432176..1433144 1 NC_010498.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1433144 astE 6145669 astE Escherichia coli SMS-3-5 succinylglutamate desuccinylase YP_001743505.1 1432176 D 439855 CDS YP_001743506.1 170681002 6145195 1433474..1433959 1 NC_010498.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1433959 spy 6145195 spy Escherichia coli SMS-3-5 periplasmic protein YP_001743506.1 1433474 D 439855 CDS YP_001743507.1 170683402 6145183 1434162..1434737 1 NC_010498.1 identified by match to protein family HMM PF05962; hypothetical protein 1434737 6145183 EcSMS35_1450 Escherichia coli SMS-3-5 hypothetical protein YP_001743507.1 1434162 D 439855 CDS YP_001743508.1 170683911 6142688 complement(1434697..1435584) 1 NC_010498.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1435584 cho 6142688 cho Escherichia coli SMS-3-5 nucleotide excision repair endonuclease YP_001743508.1 1434697 R 439855 CDS YP_001743509.1 170680478 6143207 complement(1435814..1436641) 1 NC_010498.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1436641 nadE 6143207 nadE Escherichia coli SMS-3-5 NAD synthetase YP_001743509.1 1435814 R 439855 CDS YP_001743510.1 170679970 6144647 1436843..1437181 1 NC_010498.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1437181 osmE 6144647 osmE Escherichia coli SMS-3-5 DNA-binding transcriptional activator OsmE YP_001743510.1 1436843 D 439855 CDS YP_001743511.1 170681788 6144132 1437441..1437800 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1437800 chbB 6144132 chbB Escherichia coli SMS-3-5 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_001743511.1 1437441 D 439855 CDS YP_001743512.1 170681270 6145980 1437885..1439243 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1439243 chbC 6145980 chbC Escherichia coli SMS-3-5 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_001743512.1 1437885 D 439855 CDS YP_001743513.1 170680857 6145454 1439294..1439644 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1439644 chbA 6145454 chbA Escherichia coli SMS-3-5 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_001743513.1 1439294 D 439855 CDS YP_001743514.1 170682696 6145034 1439655..1440494 1 NC_010498.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1440494 chbR 6145034 chbR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator ChbR YP_001743514.1 1439655 D 439855 CDS YP_001743515.1 170680403 6146904 1440598..1441950 1 NC_010498.1 identified by match to protein family HMM PF02056; 6-phospho-beta-glucosidase 1441950 chbF 6146904 chbF Escherichia coli SMS-3-5 6-phospho-beta-glucosidase YP_001743515.1 1440598 D 439855 CDS YP_001743516.1 170682490 6144572 1441963..1442712 1 NC_010498.1 identified by match to protein family HMM PF04794; hypothetical protein 1442712 6144572 EcSMS35_1458 Escherichia coli SMS-3-5 hypothetical protein YP_001743516.1 1441963 D 439855 CDS YP_001743517.1 170680521 6146689 complement(1442759..1445020) 1 NC_010498.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1445020 katE 6146689 katE Escherichia coli SMS-3-5 hydroperoxidase II YP_001743517.1 1442759 R 439855 CDS YP_001743518.1 170681034 6144691 1445224..1445466 1 NC_010498.1 cell division modulator 1445466 cedA 6144691 cedA Escherichia coli SMS-3-5 cell division modulator YP_001743518.1 1445224 D 439855 CDS YP_001743519.1 170683283 6145215 1445755..1446558 1 NC_010498.1 hypothetical protein 1446558 6145215 EcSMS35_1461 Escherichia coli SMS-3-5 hypothetical protein YP_001743519.1 1445755 D 439855 CDS YP_001743520.1 170683964 6147509 complement(1446562..1447953) 1 NC_010498.1 identified by match to protein family HMM PF00375; sodium/dicarboxylate symporter family protein 1447953 6147509 EcSMS35_1462 Escherichia coli SMS-3-5 sodium/dicarboxylate symporter family protein YP_001743520.1 1446562 R 439855 CDS YP_001743521.1 170681980 6143261 complement(1448086..1448676) 1 NC_010498.1 identified by match to protein family HMM PF04307; hypothetical protein 1448676 6143261 EcSMS35_1463 Escherichia coli SMS-3-5 hypothetical protein YP_001743521.1 1448086 R 439855 CDS YP_001743522.1 170682627 6146176 complement(1448839..1449507) 1 NC_010498.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1449507 6146176 EcSMS35_1464 Escherichia coli SMS-3-5 2-deoxyglucose-6-phosphatase YP_001743522.1 1448839 R 439855 CDS YP_001743523.1 170682258 6146833 1449654..1450190 1 NC_010498.1 hypothetical protein 1450190 6146833 EcSMS35_1465 Escherichia coli SMS-3-5 hypothetical protein YP_001743523.1 1449654 D 439855 CDS YP_001743524.1 170682947 6146457 complement(1450231..1451091) 1 NC_010498.1 identified by match to protein family HMM PF01636; match to protein family HMM PF03881; fructosamine kinase 1451091 6146457 EcSMS35_1466 Escherichia coli SMS-3-5 fructosamine kinase YP_001743524.1 1450231 R 439855 CDS YP_001743525.1 170680915 6147162 complement(1451197..1451487) 1 NC_010498.1 hypothetical protein 1451487 6147162 EcSMS35_1467 Escherichia coli SMS-3-5 hypothetical protein YP_001743525.1 1451197 R 439855 CDS YP_001743526.1 170680956 6145096 complement(1451588..1452517) 1 NC_010498.1 identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 6-phosphofructokinase 2 1452517 pfkB 6145096 pfkB Escherichia coli SMS-3-5 6-phosphofructokinase 2 YP_001743526.1 1451588 R 439855 CDS YP_001743527.1 170680138 6145137 1452804..1453562 1 NC_010498.1 ydiY; identified by similarity to SP:P76206; match to protein family HMM PF04338; hypothetical protein 1453562 6145137 EcSMS35_1469 Escherichia coli SMS-3-5 hypothetical protein YP_001743527.1 1452804 D 439855 CDS YP_001743528.1 170681839 6144304 complement(1453615..1453833) 1 NC_010498.1 yniD; identified by similarity to SP:Q3Z269; hypothetical protein 1453833 6144304 EcSMS35_1470 Escherichia coli SMS-3-5 hypothetical protein YP_001743528.1 1453615 R 439855 CDS YP_001743529.1 170683130 6146032 complement(1453897..1455795) 1 NC_010498.1 identified by similarity to SP:P76205; match to protein family HMM PF07906; ankyrin repeat-containing protein 1455795 6146032 EcSMS35_1471 Escherichia coli SMS-3-5 ankyrin repeat-containing protein YP_001743529.1 1453897 R 439855 CDS YP_001743530.1 170680212 6147349 1456318..1458246 1 NC_010498.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1458246 thrS 6147349 thrS Escherichia coli SMS-3-5 threonyl-tRNA synthetase YP_001743530.1 1456318 D 439855 CDS YP_001743531.1 170682199 6144378 1458358..1458792 1 NC_010498.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1458792 infC 6144378 infC Escherichia coli SMS-3-5 translation initiation factor IF-3 YP_001743531.1 1458358 D 439855 CDS YP_001743532.1 170683894 6146398 1458889..1459086 1 NC_010498.1 identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 1459086 rpmI 6146398 rpmI Escherichia coli SMS-3-5 50S ribosomal protein L35 YP_001743532.1 1458889 D 439855 CDS YP_001743533.1 170681717 6143189 1459140..1459496 1 NC_010498.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1459496 rplT 6143189 rplT Escherichia coli SMS-3-5 50S ribosomal protein L20 YP_001743533.1 1459140 D 439855 CDS YP_001743534.1 170681078 6145905 1459802..1460785 1 NC_010498.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1460785 pheS 6145905 pheS Escherichia coli SMS-3-5 phenylalanyl-tRNA synthetase subunit alpha YP_001743534.1 1459802 D 439855 CDS YP_001743535.1 170681705 6145260 1460800..1463187 1 NC_010498.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1463187 pheT 6145260 pheT Escherichia coli SMS-3-5 phenylalanyl-tRNA synthetase subunit beta YP_001743535.1 1460800 D 439855 CDS YP_001743536.1 170681870 6145891 1463192..1463491 1 NC_010498.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1463491 ihfA 6145891 ihfA Escherichia coli SMS-3-5 integration host factor subunit alpha YP_001743536.1 1463192 D 439855 CDS YP_001743537.1 170683589 6146064 1463592..1464572 1 NC_010498.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1464572 btuC 6146064 btuC Escherichia coli SMS-3-5 vtamin B12-transporter permease YP_001743537.1 1463592 D 439855 CDS YP_001743538.1 170683050 6142880 1464635..1465186 1 NC_010498.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1465186 btuE 6142880 btuE Escherichia coli SMS-3-5 putative glutathione peroxidase YP_001743538.1 1464635 D 439855 CDS YP_001743539.1 170680385 6147266 1465186..1465935 1 NC_010498.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1465935 btuD 6147266 btuD Escherichia coli SMS-3-5 vitamin B12-transporter ATPase YP_001743539.1 1465186 D 439855 CDS YP_001743540.1 170679750 6144554 1466013..1466477 1 NC_010498.1 identified by match to protein family HMM PF00877; NlpC/P60 family lipoprotein 1466477 6144554 EcSMS35_1482 Escherichia coli SMS-3-5 NlpC/P60 family lipoprotein YP_001743540.1 1466013 D 439855 CDS YP_001743541.1 170681488 6143908 1466724..1467437 1 NC_010498.1 hypothetical protein 1467437 6143908 EcSMS35_1483 Escherichia coli SMS-3-5 hypothetical protein YP_001743541.1 1466724 D 439855 CDS YP_001743542.1 170680793 6145673 1467500..1468936 1 NC_010498.1 identified by match to protein family HMM PF02696; hypothetical protein 1468936 6145673 EcSMS35_1484 Escherichia coli SMS-3-5 hypothetical protein YP_001743542.1 1467500 D 439855 CDS YP_001743543.1 170681679 6144968 complement(1468940..1469158) 1 NC_010498.1 hypothetical protein 1469158 6144968 EcSMS35_1485 Escherichia coli SMS-3-5 hypothetical protein YP_001743543.1 1468940 R 439855 CDS YP_001743544.1 170681321 6145865 complement(1469263..1470309) 1 NC_010498.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1470309 aroH 6145865 aroH Escherichia coli SMS-3-5 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001743544.1 1469263 R 439855 CDS YP_001743545.1 170682773 6145505 complement(1470466..1471299) 1 NC_010498.1 identified by match to protein family HMM PF03618; hypothetical protein 1471299 6145505 EcSMS35_1487 Escherichia coli SMS-3-5 hypothetical protein YP_001743545.1 1470466 R 439855 CDS YP_001743546.1 170683464 6146982 1471410..1471577 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1471577 6146982 EcSMS35_1488 Escherichia coli SMS-3-5 hypothetical protein YP_001743546.1 1471410 D 439855 CDS YP_001743547.1 170682331 6142753 1471631..1474009 1 NC_010498.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1474009 ppsA 6142753 ppsA Escherichia coli SMS-3-5 phosphoenolpyruvate synthase YP_001743547.1 1471631 D 439855 CDS YP_001743548.1 170683002 6146530 1474498..1475898 1 NC_010498.1 identified by similarity to SP:Q41364; match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; divalent anion:Na+ symporter (DASS) family protein 1475898 6146530 EcSMS35_1490 Escherichia coli SMS-3-5 divalent anion:Na+ symporter (DASS) family protein YP_001743548.1 1474498 D 439855 CDS YP_001743549.1 170681465 6147218 1475934..1476893 1 NC_010498.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase family protein 1476893 6147218 EcSMS35_1491 Escherichia coli SMS-3-5 D-isomer specific 2-hydroxyacid dehydrogenase family protein YP_001743549.1 1475934 D 439855 CDS YP_001743550.1 170682152 6145650 1476904..1477383 1 NC_010498.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1477383 6145650 EcSMS35_1492 Escherichia coli SMS-3-5 hypothetical protein YP_001743550.1 1476904 D 439855 CDS YP_001743551.1 170679670 6146351 1477396..1478139 1 NC_010498.1 identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase 1478139 6146351 EcSMS35_1493 Escherichia coli SMS-3-5 short chain dehydrogenase/reductase family oxidoreductase YP_001743551.1 1477396 D 439855 CDS YP_001743552.1 170680187 6143828 complement(1478190..1479830) 1 NC_010498.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1479830 fadK 6143828 fadK Escherichia coli SMS-3-5 short chain acyl-CoA synthetase YP_001743552.1 1478190 R 439855 CDS YP_001743553.1 170683668 6144353 complement(1479887..1480180) 1 NC_010498.1 iron-sulfur cluster-binding protein 1480180 6144353 EcSMS35_1495 Escherichia coli SMS-3-5 iron-sulfur cluster-binding protein YP_001743553.1 1479887 R 439855 CDS YP_001743554.1 170684211 6142960 complement(1480177..1481466) 1 NC_010498.1 identified by similarity to SP:P68644; match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM PF03486; match to protein family HMM PF07992; hypothetical protein 1481466 6142960 EcSMS35_1496 Escherichia coli SMS-3-5 hypothetical protein YP_001743554.1 1480177 R 439855 CDS YP_001743555.1 170682887 6143512 complement(1481521..1482459) 1 NC_010498.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1482459 6143512 EcSMS35_1497 Escherichia coli SMS-3-5 electron transfer flavoprotein subunit YdiR YP_001743555.1 1481521 R 439855 CDS YP_001743556.1 170682544 6147100 complement(1482479..1483243) 1 NC_010498.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1483243 6147100 EcSMS35_1498 Escherichia coli SMS-3-5 putative electron transfer flavoprotein YdiQ YP_001743556.1 1482479 R 439855 CDS YP_001743557.1 170683001 6146745 1483280..1483456 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1483456 6146745 EcSMS35_1499 Escherichia coli SMS-3-5 hypothetical protein YP_001743557.1 1483280 D 439855 CDS YP_001743558.1 170682471 6147217 1483559..1484470 1 NC_010498.1 identified by match to protein family HMM PF00165; match to protein family HMM PF02311; match to protein family HMM PF07883; AraC family transcriptional regulator 1484470 6147217 EcSMS35_1500 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001743558.1 1483559 D 439855 CDS YP_001743559.1 170684026 6146670 complement(1484513..1485667) 1 NC_010498.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase 1485667 6146670 EcSMS35_1501 Escherichia coli SMS-3-5 putative acyl-CoA dehydrogenase YP_001743559.1 1484513 R 439855 CDS YP_001743560.1 170680395 6143325 complement(1485678..1487273) 1 NC_010498.1 ydiF; identified by similarity to GB:CAB77207.1; match to protein family HMM PF01144; propionate CoA-transferase 1487273 pct 6143325 pct Escherichia coli SMS-3-5 propionate CoA-transferase YP_001743560.1 1485678 R 439855 CDS YP_001743561.1 170680493 6144564 complement(1487419..1488177) 1 NC_010498.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1488177 aroD 6144564 aroD Escherichia coli SMS-3-5 3-dehydroquinate dehydratase YP_001743561.1 1487419 R 439855 CDS YP_001743562.1 170679975 6144662 complement(1488208..1489074) 1 NC_010498.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1489074 6144662 EcSMS35_1504 Escherichia coli SMS-3-5 quinate/shikimate dehydrogenase YP_001743562.1 1488208 R 439855 CDS YP_001743563.1 170681814 6144137 complement(1489086..1490351) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 1490351 6144137 EcSMS35_1505 Escherichia coli SMS-3-5 major facilitator transporter YP_001743563.1 1489086 R 439855 CDS YP_001743564.1 170681306 6146007 complement(1490578..1491792) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator family transporter 1491792 ydiM 6146007 ydiM Escherichia coli SMS-3-5 major facilitator family transporter YP_001743564.1 1490578 R 439855 CDS YP_001743565.1 170680760 6145490 complement(1491892..1492248) 1 NC_010498.1 identified by match to protein family HMM PF08965; hypothetical protein 1492248 6145490 EcSMS35_1507 Escherichia coli SMS-3-5 hypothetical protein YP_001743565.1 1491892 R 439855 CDS YP_001743566.1 170680839 6144935 complement(1492677..1493789) 1 NC_010498.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein 1493789 ydiK 6144935 ydiK Escherichia coli SMS-3-5 putative inner membrane protein YP_001743566.1 1492677 R 439855 CDS YP_001743567.1 170681522 6145016 1494178..1497234 1 NC_010498.1 identified by match to protein family HMM PF01565; match to protein family HMM PF02913; oxidoreductase, FAD-binding 1497234 6145016 EcSMS35_1509 Escherichia coli SMS-3-5 oxidoreductase, FAD-binding YP_001743567.1 1494178 D 439855 CDS YP_001743568.1 170682148 6145707 1497231..1497641 1 NC_010498.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 1497641 ydiL 6145707 ydiL Escherichia coli SMS-3-5 hypothetical protein YP_001743568.1 1497231 D 439855 CDS YP_001743569.1 170682283 6146347 1497741..1497929 1 NC_010498.1 hypothetical protein 1497929 6146347 EcSMS35_1511 Escherichia coli SMS-3-5 hypothetical protein YP_001743569.1 1497741 D 439855 CDS YP_001743570.1 170682960 6146482 1498478..1498846 1 NC_010498.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1498846 sufA 6146482 sufA Escherichia coli SMS-3-5 iron-sulfur cluster assembly scaffold protein YP_001743570.1 1498478 D 439855 CDS YP_001743571.1 170683248 6147175 1498855..1500342 1 NC_010498.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1500342 sufB 6147175 sufB Escherichia coli SMS-3-5 cysteine desulfurase activator complex subunit SufB YP_001743571.1 1498855 D 439855 CDS YP_001743572.1 170683761 6147471 1500352..1501098 1 NC_010498.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase component 1501098 sufC 6147471 sufC Escherichia coli SMS-3-5 cysteine desulfurase ATPase component YP_001743572.1 1500352 D 439855 CDS YP_001743573.1 170680131 6143053 1501073..1502344 1 NC_010498.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1502344 sufD 6143053 sufD Escherichia coli SMS-3-5 cysteine desulfurase activator complex subunit SufD YP_001743573.1 1501073 D 439855 CDS YP_001743574.1 170680646 6144297 1502341..1503561 1 NC_010498.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1503561 sufS 6144297 sufS Escherichia coli SMS-3-5 bifunctional cysteine desulfurase/selenocysteine lyase YP_001743574.1 1502341 D 439855 CDS YP_001743575.1 170680508 6144821 1503574..1503990 1 NC_010498.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1503990 sufE 6144821 sufE Escherichia coli SMS-3-5 cysteine desufuration protein SufE YP_001743575.1 1503574 D 439855 CDS YP_001743576.1 170682137 6144678 1504139..1505143 1 NC_010498.1 identified by match to protein family HMM PF01476; match to protein family HMM PF03734; LysM/ErfK/YbiS/YcfS/YnhG family protein 1505143 6144678 EcSMS35_1518 Escherichia coli SMS-3-5 LysM/ErfK/YbiS/YcfS/YnhG family protein YP_001743576.1 1504139 D 439855 CDS YP_001743577.1 170682645 6146336 complement(1505207..1505443) 1 NC_010498.1 identified by match to protein family HMM PF04728; major outer membrane lipoprotein 1505443 lpp 6146336 lpp Escherichia coli SMS-3-5 major outer membrane lipoprotein YP_001743577.1 1505207 R 439855 CDS YP_001743578.1 170683460 6146852 complement(1505754..1507166) 1 NC_010498.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1507166 pykF 6146852 pykF Escherichia coli SMS-3-5 pyruvate kinase YP_001743578.1 1505754 R 439855 CDS YP_001743579.1 170683892 6142748 1507762..1507932 1 NC_010498.1 hypothetical protein 1507932 6142748 EcSMS35_1521 Escherichia coli SMS-3-5 hypothetical protein YP_001743579.1 1507762 D 439855 CDS YP_001743580.1 170679944 6143187 complement(1508223..1508360) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1508360 6143187 EcSMS35_1522 Escherichia coli SMS-3-5 hypothetical protein YP_001743580.1 1508223 R 439855 CDS YP_001743581.1 170680484 6144106 1508388..1509014 1 NC_010498.1 identified by match to protein family HMM PF00037; hypothetical protein 1509014 6144106 EcSMS35_1523 Escherichia coli SMS-3-5 hypothetical protein YP_001743581.1 1508388 D 439855 CDS YP_001743582.1 170681360 6144653 1509035..1511137 1 NC_010498.1 identified by match to protein family HMM PF01314; match to protein family HMM PF02730; putative oxidoreductase 1511137 6144653 EcSMS35_1524 Escherichia coli SMS-3-5 putative oxidoreductase YP_001743582.1 1509035 D 439855 CDS YP_001743583.1 170681892 6145544 1511150..1511788 1 NC_010498.1 hypothetical protein 1511788 6145544 EcSMS35_1525 Escherichia coli SMS-3-5 hypothetical protein YP_001743583.1 1511150 D 439855 CDS YP_001743584.1 170682806 6146086 1511801..1512520 1 NC_010498.1 identified by match to protein family HMM PF00037; iron-sulfur cluster-binding protein 1512520 6146086 EcSMS35_1526 Escherichia coli SMS-3-5 iron-sulfur cluster-binding protein YP_001743584.1 1511801 D 439855 CDS YP_001743585.1 170680766 6147017 1512517..1513302 1 NC_010498.1 identified by match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit 1513302 6147017 EcSMS35_1527 Escherichia coli SMS-3-5 nickel-dependent hydrogenase, b-type cytochrome subunit YP_001743585.1 1512517 D 439855 CDS YP_001743586.1 170680009 6144941 1513306..1514118 1 NC_010498.1 ydhT; identified by similarity to SP:P77147; hypothetical protein 1514118 6144941 EcSMS35_1528 Escherichia coli SMS-3-5 hypothetical protein YP_001743586.1 1513306 D 439855 CDS YP_001743587.1 170680041 6145932 complement(1515853..1516158) 1 NC_010498.1 identified by match to protein family HMM PF08803; hypothetical protein 1516158 ydhR 6145932 ydhR Escherichia coli SMS-3-5 hypothetical protein YP_001743587.1 1515853 R 439855 CDS YP_001743588.1 170682120 6143700 1516732..1517988 1 NC_010498.1 hypothetical protein 1517988 6143700 EcSMS35_1533 Escherichia coli SMS-3-5 hypothetical protein YP_001743588.1 1516732 D 439855 CDS YP_001743589.1 170682804 6146318 complement(1518029..1519402) 1 NC_010498.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1519402 6146318 EcSMS35_1534 Escherichia coli SMS-3-5 multidrug efflux protein YP_001743589.1 1518029 R 439855 CDS YP_001743590.1 170683708 6147015 1519617..1520258 1 NC_010498.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1520258 ribE 6147015 ribE Escherichia coli SMS-3-5 riboflavin synthase subunit alpha YP_001743590.1 1519617 D 439855 CDS YP_001743591.1 170682135 6143000 complement(1520298..1521446) 1 NC_010498.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1521446 cfa 6143000 cfa Escherichia coli SMS-3-5 cyclopropane fatty acyl phospholipid synthase YP_001743591.1 1520298 R 439855 CDS YP_001743592.1 170680618 6146334 complement(1521737..1522948) 1 NC_010498.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1522948 6146334 EcSMS35_1537 Escherichia coli SMS-3-5 inner membrane transport protein YdhC YP_001743592.1 1521737 R 439855 CDS YP_001743593.1 170682980 6144792 1523061..1523993 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 1523993 6144792 EcSMS35_1539 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001743593.1 1523061 D 439855 CDS YP_001743594.1 170683174 6147195 complement(1523990..1525015) 1 NC_010498.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1525015 purR 6147195 purR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor PurR YP_001743594.1 1523990 R 439855 CDS YP_001743595.1 170682303 6147394 1525284..1525403 1 NC_010498.1 identified by Glimmer3; putative; membrane protein 1525403 6147394 EcSMS35_1540 Escherichia coli SMS-3-5 membrane protein YP_001743595.1 1525284 D 439855 CDS YP_001743596.1 170684306 6146502 1525569..1526738 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 1526738 6146502 EcSMS35_1541 Escherichia coli SMS-3-5 major facilitator transporter YP_001743596.1 1525569 D 439855 CDS YP_001743597.1 170683613 6143608 complement(1526884..1527465) 1 NC_010498.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1527465 sodB 6143608 sodB Escherichia coli SMS-3-5 superoxide dismutase YP_001743597.1 1526884 R 439855 CDS YP_001743598.1 170683187 6142903 complement(1527593..1528420) 1 NC_010498.1 identified by match to protein family HMM PF00877; NlpC/P60 family protein 1528420 6142903 EcSMS35_1543 Escherichia coli SMS-3-5 NlpC/P60 family protein YP_001743598.1 1527593 R 439855 CDS YP_001743599.1 170680379 6147407 1528755..1529102 1 NC_010498.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR00365; hypothetical protein 1529102 6147407 EcSMS35_1544 Escherichia coli SMS-3-5 hypothetical protein YP_001743599.1 1528755 D 439855 CDS YP_001743600.1 170679759 6144548 complement(1529153..1533769) 1 NC_010498.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr 1533769 lhr 6144548 lhr Escherichia coli SMS-3-5 putative ATP-dependent helicase Lhr YP_001743600.1 1529153 R 439855 CDS YP_001743601.1 170681755 6143918 complement(1533862..1534509) 1 NC_010498.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1534509 rnt 6143918 rnt Escherichia coli SMS-3-5 ribonuclease T YP_001743601.1 1533862 R 439855 CDS YP_001743602.1 170680256 6145946 complement(1534612..1535019) 1 NC_010498.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1535019 gloA 6145946 gloA Escherichia coli SMS-3-5 glyoxalase I YP_001743602.1 1534612 R 439855 CDS YP_001743603.1 170683580 6144423 complement(1535100..1536197) 1 NC_010498.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1536197 nemA 6144423 nemA Escherichia coli SMS-3-5 N-ethylmaleimide reductase YP_001743603.1 1535100 R 439855 CDS YP_001743604.1 170683234 6142871 complement(1536234..1536833) 1 NC_010498.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1536833 6142871 EcSMS35_1549 Escherichia coli SMS-3-5 TetR family transcriptional regulator YP_001743604.1 1536234 R 439855 CDS YP_001743605.1 170683126 6147455 1536798..1537175 1 NC_010498.1 identified by match to protein family HMM PF06945; hypothetical protein 1537175 6147455 EcSMS35_1550 Escherichia coli SMS-3-5 hypothetical protein YP_001743605.1 1536798 D 439855 CDS YP_001743606.1 170683938 6147345 1537224..1538120 1 NC_010498.1 identified by match to protein family HMM PF00248; oxidoreductase YdhF 1538120 ydhF 6147345 ydhF Escherichia coli SMS-3-5 oxidoreductase YdhF YP_001743606.1 1537224 D 439855 CDS YP_001743607.1 170682074 6143234 1538201..1538722 1 NC_010498.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1538722 sodC_1 6143234 sodC_1 Escherichia coli SMS-3-5 superoxide dismutase YP_001743607.1 1538201 D 439855 CDS YP_001743608.1 170682942 6146271 complement(1538723..1540735) 1 NC_010498.1 identified by match to protein family HMM PF04632; fusaric acid resistance domain-containing protein 1540735 6146271 EcSMS35_1553 Escherichia coli SMS-3-5 fusaric acid resistance domain-containing protein YP_001743608.1 1538723 R 439855 CDS YP_001743609.1 170681193 6147156 complement(1540735..1541592) 1 NC_010498.1 identified by match to protein family HMM PF00529; MFP family transporter 1541592 6147156 EcSMS35_1554 Escherichia coli SMS-3-5 MFP family transporter YP_001743609.1 1540735 R 439855 CDS YP_001743610.1 170681662 6145377 complement(1541595..1541831) 1 NC_010498.1 identified by match to protein family HMM PF07869; hypothetical protein 1541831 6145377 EcSMS35_1555 Escherichia coli SMS-3-5 hypothetical protein YP_001743610.1 1541595 R 439855 CDS YP_001743611.1 170680115 6145848 1541888..1542007 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1542007 6145848 EcSMS35_1556 Escherichia coli SMS-3-5 hypothetical protein YP_001743611.1 1541888 D 439855 CDS YP_001743612.1 170683212 6144280 1542032..1542466 1 NC_010498.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1542466 6144280 EcSMS35_1557 Escherichia coli SMS-3-5 transcriptional regulator SlyA YP_001743612.1 1542032 D 439855 CDS YP_001743613.1 170681418 6147433 complement(1542513..1542980) 1 NC_010498.1 identified by match to protein family HMM PF05433; outer membrane lipoprotein SlyB 1542980 slyB 6147433 slyB Escherichia coli SMS-3-5 outer membrane lipoprotein SlyB YP_001743613.1 1542513 R 439855 CDS YP_001743614.1 170680769 6145602 1543254..1544363 1 NC_010498.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1544363 anmK 6145602 anmK Escherichia coli SMS-3-5 anhydro-N-acetylmuramic acid kinase YP_001743614.1 1543254 D 439855 CDS YP_001743615.1 170680469 6144944 1544461..1544790 1 NC_010498.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1544790 6144944 EcSMS35_1560 Escherichia coli SMS-3-5 lysozyme inhibitor YP_001743615.1 1544461 D 439855 CDS YP_001743616.1 170679963 6144638 1544849..1545505 1 NC_010498.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1545505 pdxH 6144638 pdxH Escherichia coli SMS-3-5 pyridoxamine 5'-phosphate oxidase YP_001743616.1 1544849 D 439855 CDS YP_001743617.1 170683918 6144125 1545634..1546908 1 NC_010498.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1546908 tyrS 6144125 tyrS Escherichia coli SMS-3-5 tyrosyl-tRNA synthetase YP_001743617.1 1545634 D 439855 CDS YP_001743618.1 170683400 6143214 1546970..1547830 1 NC_010498.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1547830 pdxY 6143214 pdxY Escherichia coli SMS-3-5 pyridoxamine kinase YP_001743618.1 1546970 D 439855 CDS YP_001743619.1 170682568 6142686 complement(1547874..1548479) 1 NC_010498.1 identified by similarity to SP:P0A9D2; match to protein family HMM PF00043; match to protein family HMM PF02798; glutathionine S-transferase 1548479 gst 6142686 gst Escherichia coli SMS-3-5 glutathionine S-transferase YP_001743619.1 1547874 R 439855 CDS YP_001743620.1 170682111 6146773 complement(1548584..1550086) 1 NC_010498.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1550086 tppB 6146773 tppB Escherichia coli SMS-3-5 putative tripeptide transporter permease YP_001743620.1 1548584 R 439855 CDS YP_001743621.1 170681381 6146309 complement(1550696..1551331) 1 NC_010498.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1551331 nth 6146309 nth Escherichia coli SMS-3-5 endonuclease III YP_001743621.1 1550696 R 439855 CDS YP_001743622.1 170680858 6145565 complement(1551331..1552026) 1 NC_010498.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1552026 rnfE 6145565 rnfE Escherichia coli SMS-3-5 electron transport complex RsxE subunit YP_001743622.1 1551331 R 439855 CDS YP_001743623.1 170682231 6145035 complement(1552030..1552650) 1 NC_010498.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1552650 rnfG 6145035 rnfG Escherichia coli SMS-3-5 electron transport complex protein RnfG YP_001743623.1 1552030 R 439855 CDS YP_001743624.1 170682943 6146430 complement(1552654..1553712) 1 NC_010498.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1553712 rnfD 6146430 rnfD Escherichia coli SMS-3-5 electron transport complex protein RnfD YP_001743624.1 1552654 R 439855 CDS YP_001743625.1 170682353 6147157 complement(1553713..1555743) 1 NC_010498.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1555743 rnfC 6147157 rnfC Escherichia coli SMS-3-5 electron transport complex protein RnfC YP_001743625.1 1553713 R 439855 CDS YP_001743626.1 170682878 6146552 complement(1555736..1556314) 1 NC_010498.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1556314 rnfB 6146552 rnfB Escherichia coli SMS-3-5 electron transport complex protein RnfB YP_001743626.1 1555736 R 439855 CDS YP_001743627.1 170680993 6147091 complement(1556314..1556895) 1 NC_010498.1 identified by similarity to SP:P0A766; match to protein family HMM PF02508; match to protein family HMM TIGR01943; Na(+)-translocating NADH-quinone reductase subunit E 1556895 rnfA 6147091 rnfA Escherichia coli SMS-3-5 Na(+)-translocating NADH-quinone reductase subunit E YP_001743627.1 1556314 R 439855 CDS YP_001743628.1 170681496 6145174 complement(1556972..1557412) 1 NC_010498.1 hypothetical protein 1557412 6145174 EcSMS35_1573 Escherichia coli SMS-3-5 hypothetical protein YP_001743628.1 1556972 R 439855 CDS YP_001743629.1 170679680 6145681 complement(1557498..1557713) 1 NC_010498.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1557713 6145681 EcSMS35_1574 Escherichia coli SMS-3-5 oriC-binding nucleoid-associated protein YP_001743629.1 1557498 R 439855 CDS YP_001743630.1 170680179 6143838 1558354..1559394 1 NC_010498.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; putative oxidoreductase 1559394 6143838 EcSMS35_1575 Escherichia coli SMS-3-5 putative oxidoreductase YP_001743630.1 1558354 D 439855 CDS YP_001743631.1 170684142 6144345 complement(1559430..1560431) 1 NC_010498.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1560431 add 6144345 add Escherichia coli SMS-3-5 adenosine deaminase YP_001743631.1 1559430 R 439855 CDS YP_001743632.1 170682436 6143442 complement(1560535..1561707) 1 NC_010498.1 identified by similarity to SP:P23256; match to protein family HMM PF00155; maltose regulon modulator MalY 1561707 malY 6143442 malY Escherichia coli SMS-3-5 maltose regulon modulator MalY YP_001743632.1 1560535 R 439855 CDS YP_001743633.1 170681681 6146635 complement(1561717..1563309) 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1563309 malX 6146635 malX Escherichia coli SMS-3-5 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_001743633.1 1561717 R 439855 CDS YP_001743634.1 170681507 6145867 1563484..1564512 1 NC_010498.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1564512 malI 6145867 malI Escherichia coli SMS-3-5 DNA-binding transcriptional repressor MalI YP_001743634.1 1563484 D 439855 CDS YP_001743635.1 170680639 6145692 1564624..1565391 1 NC_010498.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1565391 6145692 EcSMS35_1580 Escherichia coli SMS-3-5 7-alpha-hydroxysteroid dehydrogenase YP_001743635.1 1564624 D 439855 CDS YP_001743636.1 170679903 6144814 1565631..1566209 1 NC_010498.1 identified by match to protein family HMM PF00440; transcriptional regulator UidR 1566209 uidR 6144814 uidR Escherichia coli SMS-3-5 transcriptional regulator UidR YP_001743636.1 1565631 D 439855 CDS YP_001743637.1 170683754 6144065 1566599..1568410 1 NC_010498.1 identified by match to protein family HMM PF00703; match to protein family HMM PF02836; match to protein family HMM PF02837; beta-D-glucuronidase 1568410 uidA 6144065 uidA Escherichia coli SMS-3-5 beta-D-glucuronidase YP_001743637.1 1566599 D 439855 CDS YP_001743638.1 170683190 6143046 1568407..1569780 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792; glucuronide transporter 1569780 uidB 6143046 uidB Escherichia coli SMS-3-5 glucuronide transporter YP_001743638.1 1568407 D 439855 CDS YP_001743639.1 170682689 6147410 1569837..1571084 1 NC_010498.1 putative outer membrane porin protein 1571084 uidC 6147410 uidC Escherichia coli SMS-3-5 putative outer membrane porin protein YP_001743639.1 1569837 D 439855 CDS YP_001743640.1 170682142 6146897 complement(1571129..1572637) 1 NC_010498.1 identified by match to protein family HMM PF06097; hypothetical protein 1572637 6146897 EcSMS35_1585 Escherichia coli SMS-3-5 hypothetical protein YP_001743640.1 1571129 R 439855 CDS YP_001743641.1 170682319 6146341 complement(1572738..1573913) 1 NC_010498.1 identified by similarity to SP:P00946; match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase, class I 1573913 manA 6146341 manA Escherichia coli SMS-3-5 mannose-6-phosphate isomerase, class I YP_001743641.1 1572738 R 439855 CDS YP_001743642.1 170682150 6146518 1574112..1575758 1 NC_010498.1 identified by similarity to SP:P0AC33; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase 1575758 fumA 6146518 fumA Escherichia coli SMS-3-5 fumarate hydratase YP_001743642.1 1574112 D 439855 CDS YP_001743643.1 170681319 6146349 1575901..1577304 1 NC_010498.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1577304 fumC 6146349 fumC Escherichia coli SMS-3-5 fumarate hydratase YP_001743643.1 1575901 D 439855 CDS YP_001743644.1 170680500 6145503 complement(1577301..1578242) 1 NC_010498.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1578242 tus 6145503 tus Escherichia coli SMS-3-5 DNA replication terminus site-binding protein YP_001743644.1 1577301 R 439855 CDS YP_001743645.1 170682743 6144669 complement(1578306..1579607) 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein RstB 1579607 rstB 6144669 rstB Escherichia coli SMS-3-5 sensor protein RstB YP_001743645.1 1578306 R 439855 CDS YP_001743646.1 170683236 6146951 complement(1579611..1580330) 1 NC_010498.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1580330 rstA 6146951 rstA Escherichia coli SMS-3-5 DNA-binding transcriptional regulator RstA YP_001743646.1 1579611 R 439855 CDS YP_001743647.1 170680025 6147457 1580459..1580794 1 NC_010498.1 identified by match to protein family HMM PF06942; hypothetical protein 1580794 6147457 EcSMS35_1593 Escherichia coli SMS-3-5 hypothetical protein YP_001743647.1 1580459 D 439855 CDS YP_001743648.1 170683762 6144188 complement(1580791..1581513) 1 NC_010498.1 identified by match to protein family HMM PF00106; short chain dehydrogenase 1581513 6144188 EcSMS35_1592 Escherichia coli SMS-3-5 short chain dehydrogenase YP_001743648.1 1580791 R 439855 CDS YP_001743649.1 170680556 6143054 complement(1581550..1582932) 1 NC_010498.1 identified by match to protein family HMM PF00324; match to protein family HMM TIGR00905; arginine/ornithine antiporter 1582932 arcD 6143054 arcD Escherichia coli SMS-3-5 arginine/ornithine antiporter YP_001743649.1 1581550 R 439855 CDS YP_001743650.1 170681099 6144726 complement(1583118..1584062) 1 NC_010498.1 identified by match to protein family HMM PF07338; YdgH protein 1584062 ydgH 6144726 ydgH Escherichia coli SMS-3-5 YdgH protein YP_001743650.1 1583118 R 439855 CDS YP_001743651.1 170682207 6145281 1584587..1586119 1 NC_010498.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1586119 pntA 6145281 pntA Escherichia coli SMS-3-5 NAD(P) transhydrogenase subunit alpha YP_001743651.1 1584587 D 439855 CDS YP_001743652.1 170682723 6146406 1586130..1587518 1 NC_010498.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1587518 pntB 6146406 pntB Escherichia coli SMS-3-5 pyridine nucleotide transhydrogenase YP_001743652.1 1586130 D 439855 CDS YP_001743653.1 170683134 6146931 complement(1587543..1588577) 1 NC_010498.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein 1588577 tqsA 6146931 tqsA Escherichia coli SMS-3-5 putative transport protein YP_001743653.1 1587543 R 439855 CDS YP_001743654.1 170683606 6147353 1588989..1589354 1 NC_010498.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1589354 mdtJ 6147353 mdtJ Escherichia coli SMS-3-5 multidrug efflux system protein MdtJ YP_001743654.1 1588989 D 439855 CDS YP_001743655.1 170682978 6142896 1589341..1589670 1 NC_010498.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1589670 mdtI 6142896 mdtI Escherichia coli SMS-3-5 multidrug efflux system protein MdtI YP_001743655.1 1589341 D 439855 CDS YP_001743656.1 170684042 6147193 complement(1589709..1590530) 1 NC_010498.1 identified by match to protein family HMM PF00089; S1A family peptidase 1590530 6147193 EcSMS35_1601 Escherichia coli SMS-3-5 S1A family peptidase YP_001743656.1 1589709 R 439855 CDS YP_001743657.1 170681639 6143341 complement(1590806..1591078) 1 NC_010498.1 required for growth and survival under moderately acid conditions; acid shock protein precursor 1591078 6143341 EcSMS35_1602 Escherichia coli SMS-3-5 acid shock protein precursor YP_001743657.1 1590806 R 439855 CDS YP_001743658.1 170681161 6145825 1591190..1592398 1 NC_010498.1 identified by match to protein family HMM PF01609; IS10 transposase 1592398 6145825 EcSMS35_1603 Escherichia coli SMS-3-5 IS10 transposase YP_001743658.1 1591190 D 439855 CDS YP_001743659.1 170680108 6145345 complement(1592877..1594130) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator family transporter 1594130 ynfM 6145345 ynfM Escherichia coli SMS-3-5 major facilitator family transporter YP_001743659.1 1592877 R 439855 CDS YP_001743660.1 170680231 6144272 1594237..1595130 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1595130 6144272 EcSMS35_1605 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743660.1 1594237 D 439855 CDS YP_001743661.1 170679760 6144397 1595265..1596485 1 NC_010498.1 identified by match to protein family HMM PF00480; transcriptional regulator Mic 1596485 mic 6144397 mic Escherichia coli SMS-3-5 transcriptional regulator Mic YP_001743661.1 1595265 D 439855 CDS YP_001743662.1 170684001 6143919 1596610..1597305 1 NC_010498.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1597305 bioD2 6143919 bioD2 Escherichia coli SMS-3-5 putative dithiobiotin synthetase YP_001743662.1 1596610 D 439855 CDS YP_001743663.1 170682758 6143300 complement(1597258..1598514) 1 NC_010498.1 identified by match to protein family HMM PF00654; putative voltage-gated ClC-type chloride channel ClcB 1598514 6143300 EcSMS35_1607 Escherichia coli SMS-3-5 putative voltage-gated ClC-type chloride channel ClcB YP_001743663.1 1597258 R 439855 CDS YP_001743664.1 170680290 6146967 complement(1598709..1599323) 1 NC_010498.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1599323 dmsD 6146967 dmsD Escherichia coli SMS-3-5 twin-argninine leader-binding protein DmsD YP_001743664.1 1598709 R 439855 CDS YP_001743665.1 170680653 6144458 complement(1599366..1600220) 1 NC_010498.1 identified by match to protein family HMM PF04976; anaerobic dimethyl sulfoxide reductase, C subunit 1600220 dmsC2 6144458 dmsC2 Escherichia coli SMS-3-5 anaerobic dimethyl sulfoxide reductase, C subunit YP_001743665.1 1599366 R 439855 CDS YP_001743666.1 170679927 6144828 complement(1600222..1600839) 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951; dimethylsulfoxide reductase, B subunit 1600839 dmsB_1 6144828 dmsB_1 Escherichia coli SMS-3-5 dimethylsulfoxide reductase, B subunit YP_001743666.1 1600222 R 439855 CDS YP_001743667.1 170682222 6147198 complement(1603333..1605759) 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit YnfE 1605759 ynfE 6147198 ynfE Escherichia coli SMS-3-5 anaerobic dimethyl sulfoxide reductase, A subunit YnfE YP_001743667.1 1603333 R 439855 CDS YP_001743668.1 170681546 6146421 complement(1605958..1606263) 1 NC_010498.1 identified by match to protein family HMM PF06649; hypothetical protein 1606263 6146421 EcSMS35_1614 Escherichia coli SMS-3-5 hypothetical protein YP_001743668.1 1605958 R 439855 CDS YP_001743669.1 170680891 6145731 1606335..1607081 1 NC_010498.1 identified by match to protein family HMM PF06788; hypothetical protein 1607081 6145731 EcSMS35_1615 Escherichia coli SMS-3-5 hypothetical protein YP_001743669.1 1606335 D 439855 CDS YP_001743670.1 170682991 6145069 complement(1607084..1607644) 1 NC_010498.1 identified by match to protein family HMM PF00583; diamine N-acetyltransferase 1607644 speG 6145069 speG Escherichia coli SMS-3-5 diamine N-acetyltransferase YP_001743670.1 1607084 R 439855 CDS YP_001743671.1 170680551 6147207 complement(1607679..1608020) 1 NC_010498.1 identified by match to protein family HMM PF06932; hypothetical protein 1608020 6147207 EcSMS35_1617 Escherichia coli SMS-3-5 hypothetical protein YP_001743671.1 1607679 R 439855 CDS YP_001743672.1 170683618 6144721 1608155..1608481 1 NC_010498.1 identified by match to protein family HMM PF02694; hypothetical protein 1608481 6144721 EcSMS35_1618 Escherichia coli SMS-3-5 hypothetical protein YP_001743672.1 1608155 D 439855 CDS YP_001743673.1 170684261 6142908 1608687..1609901 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; starvation-sensing protein RspA 1609901 rspA 6142908 rspA Escherichia coli SMS-3-5 starvation-sensing protein RspA YP_001743673.1 1608687 D 439855 CDS YP_001743674.1 170681959 6143563 1609913..1610932 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; putative dehydrogenase 1610932 rspB 6143563 rspB Escherichia coli SMS-3-5 putative dehydrogenase YP_001743674.1 1609913 D 439855 CDS YP_001743675.1 170680764 6146155 1610990..1612357 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; inner membrane metabolite transport protein ydfJ 1612357 ydfJ 6146155 ydfJ Escherichia coli SMS-3-5 inner membrane metabolite transport protein ydfJ YP_001743675.1 1610990 D 439855 CDS YP_001743676.1 170681422 6144939 1612320..1612436 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1612436 6144939 EcSMS35_1622 Escherichia coli SMS-3-5 hypothetical protein YP_001743676.1 1612320 D 439855 CDS YP_001743677.1 170679858 6145606 1612446..1613906 1 NC_010498.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase family protein 1613906 6145606 EcSMS35_1623 Escherichia coli SMS-3-5 mannitol dehydrogenase family protein YP_001743677.1 1612446 D 439855 CDS YP_001743678.1 170679938 6144020 complement(1613942..1614145) 1 NC_010498.1 identified by match to protein family HMM TIGR03318; hypothetical protein 1614145 6144020 EcSMS35_1624 Escherichia coli SMS-3-5 hypothetical protein YP_001743678.1 1613942 R 439855 CDS YP_001743679.1 170679935 6144100 complement(1614322..1615008) 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 1615008 6144100 EcSMS35_1625 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001743679.1 1614322 R 439855 CDS YP_001743680.1 170680775 6144097 complement(1615097..1615843) 1 NC_010498.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1615843 6144097 EcSMS35_1626 Escherichia coli SMS-3-5 3-hydroxy acid dehydrogenase YP_001743680.1 1615097 R 439855 CDS YP_001743681.1 170681397 6144950 1615980..1618025 1 NC_010498.1 identified by match to protein family HMM PF01432; dipeptidyl carboxypeptidase II 1618025 dcp 6144950 dcp Escherichia coli SMS-3-5 dipeptidyl carboxypeptidase II YP_001743681.1 1615980 D 439855 CDS YP_001743682.1 170681831 6145581 1618388..1618780 1 NC_010498.1 ydeI; identified by match to protein family HMM PF04076; match to protein family HMM TIGR00156; hypothetical protein 1618780 6145581 EcSMS35_1628 Escherichia coli SMS-3-5 hypothetical protein YP_001743682.1 1618388 D 439855 CDS YP_001743683.1 170681992 6146024 1619035..1619925 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; hypothetical protein 1619925 6146024 EcSMS35_1629 Escherichia coli SMS-3-5 hypothetical protein YP_001743683.1 1619035 D 439855 CDS YP_001743684.1 170682596 6146188 complement(1620366..1621553) 1 NC_010498.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1621553 ydeE 6146188 ydeE Escherichia coli SMS-3-5 putative MFS-type transporter YdeE YP_001743684.1 1620366 R 439855 CDS YP_001743685.1 170682899 6146801 1621748..1622647 1 NC_010498.1 identified by match to protein family HMM PF00892; match to protein family HMM PF03151; O-acetylserine/cysteine export protein 1622647 eamA 6146801 eamA Escherichia coli SMS-3-5 O-acetylserine/cysteine export protein YP_001743685.1 1621748 D 439855 CDS YP_001743686.1 170681310 6147112 complement(1622692..1623390) 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1623390 6147112 EcSMS35_1632 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001743686.1 1622692 R 439855 CDS YP_001743687.1 170679787 6145494 1623589..1623900 1 NC_010498.1 identified by match to protein family HMM PF02302; PTS system lactose/cellobiose family IIB subunit 1623900 6145494 EcSMS35_1633 Escherichia coli SMS-3-5 PTS system lactose/cellobiose family IIB subunit YP_001743687.1 1623589 D 439855 CDS YP_001743688.1 170680463 6143947 1624014..1625336 1 NC_010498.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system lactose/cellobiose family IIC subunit 1625336 6143947 EcSMS35_1634 Escherichia coli SMS-3-5 PTS system lactose/cellobiose family IIC subunit YP_001743688.1 1624014 D 439855 CDS YP_001743689.1 170683356 6144632 1625364..1625675 1 NC_010498.1 identified by match to protein family HMM PF02255; PTS system lactose/cellobiose-specific family IIA subunit 1625675 6144632 EcSMS35_1635 Escherichia coli SMS-3-5 PTS system lactose/cellobiose-specific family IIA subunit YP_001743689.1 1625364 D 439855 CDS YP_001743690.1 170680584 6142642 1625731..1627404 1 NC_010498.1 identified by similarity to SP:P26218; match to protein family HMM PF02264; glucoside specific outer membrane porin BglH 1627404 bglH 6142642 bglH Escherichia coli SMS-3-5 glucoside specific outer membrane porin BglH YP_001743690.1 1625731 D 439855 CDS YP_001743691.1 170683087 6144754 1627429..1628868 1 NC_010498.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1628868 celA 6144754 celA Escherichia coli SMS-3-5 6-phospho-beta-glucosidase YP_001743691.1 1627429 D 439855 CDS YP_001743692.1 170682435 6147304 complement(1628925..1629143) 1 NC_010498.1 hypothetical protein 1629143 marB 6147304 marB Escherichia coli SMS-3-5 hypothetical protein YP_001743692.1 1628925 R 439855 CDS YP_001743693.1 170684233 6146634 complement(1629175..1629558) 1 NC_010498.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1629558 marA 6146634 marA Escherichia coli SMS-3-5 DNA-binding transcriptional activator MarA YP_001743693.1 1629175 R 439855 CDS YP_001743694.1 170683414 6143534 complement(1629579..1630013) 1 NC_010498.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1630013 marR 6143534 marR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor MarR YP_001743694.1 1629579 R 439855 CDS YP_001743695.1 170680289 6142700 1630225..1630890 1 NC_010498.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1630890 marC 6142700 marC Escherichia coli SMS-3-5 multiple drug resistance protein MarC YP_001743695.1 1630225 D 439855 CDS YP_001743696.1 170680058 6144457 complement(1630915..1632105) 1 NC_010498.1 identified by match to protein family HMM PF07690; sugar efflux transporter 1632105 sotB 6144457 sotB Escherichia coli SMS-3-5 sugar efflux transporter YP_001743696.1 1630915 R 439855 CDS YP_001743697.1 170681467 6144222 1632023..1632145 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1632145 6144222 EcSMS35_1643 Escherichia coli SMS-3-5 hypothetical protein YP_001743697.1 1632023 D 439855 CDS YP_001743698.1 170681472 6145652 1632182..1632301 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1632301 6145652 EcSMS35_1645 Escherichia coli SMS-3-5 hypothetical protein YP_001743698.1 1632182 D 439855 CDS YP_001743699.1 170680980 6145657 complement(1632255..1633370) 1 NC_010498.1 hypothetical protein 1633370 6145657 EcSMS35_1644 Escherichia coli SMS-3-5 hypothetical protein YP_001743699.1 1632255 R 439855 CDS YP_001743700.1 170682090 6145161 complement(1633448..1634329) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1634329 6145161 EcSMS35_1646 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743700.1 1633448 R 439855 CDS YP_001743701.1 170684086 6146287 1634430..1635818 1 NC_010498.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase 1635818 6146287 EcSMS35_1647 Escherichia coli SMS-3-5 putative succinate semialdehyde dehydrogenase YP_001743701.1 1634430 D 439855 CDS YP_001743702.1 170683424 6143386 1635882..1636808 1 NC_010498.1 catalyzes the formation of glutamate from glutamine; glutaminase 1636808 glsA2 6143386 glsA2 Escherichia coli SMS-3-5 glutaminase YP_001743702.1 1635882 D 439855 CDS YP_001743703.1 170684186 6142711 1636808..1637167 1 NC_010498.1 hypothetical protein 1637167 6142711 EcSMS35_1649 Escherichia coli SMS-3-5 hypothetical protein YP_001743703.1 1636808 D 439855 CDS YP_001743704.1 170683666 6143487 1637306..1638724 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1638724 6143487 EcSMS35_1650 Escherichia coli SMS-3-5 diguanylate cyclase YP_001743704.1 1637306 D 439855 CDS YP_001743705.1 170679585 6142958 1638952..1640403 1 NC_010498.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1640403 uxaB 6142958 uxaB Escherichia coli SMS-3-5 altronate oxidoreductase YP_001743705.1 1638952 D 439855 CDS YP_001743706.1 170681385 6143742 1640600..1641514 1 NC_010498.1 identified by match to protein family HMM PF05249; hypothetical protein 1641514 6143742 EcSMS35_1652 Escherichia coli SMS-3-5 hypothetical protein YP_001743706.1 1640600 D 439855 CDS YP_001743707.1 170681176 6145569 complement(1641518..1642276) 1 NC_010498.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1642276 tam 6145569 tam Escherichia coli SMS-3-5 trans-aconitate 2-methyltransferase YP_001743707.1 1641518 R 439855 CDS YP_001743708.1 170682706 6145360 complement(1642333..1642623) 1 NC_010498.1 identified by match to protein family HMM PF03992; autoinducer-2 (AI-2) modifying protein LsrG 1642623 lsrG 6145360 lsrG Escherichia coli SMS-3-5 autoinducer-2 (AI-2) modifying protein LsrG YP_001743708.1 1642333 R 439855 CDS YP_001743709.1 170682465 6146914 complement(1642647..1643522) 1 NC_010498.1 identified by match to protein family HMM PF01791; aldolase 1643522 lsrF 6146914 lsrF Escherichia coli SMS-3-5 aldolase YP_001743709.1 1642647 R 439855 CDS YP_001743710.1 170683902 6146664 complement(1643549..1644571) 1 NC_010498.1 autoinducer-2 ABC transporter periplasmic autoinducer-2-binding protein LsrB 1644571 lsrB 6146664 lsrB Escherichia coli SMS-3-5 autoinducer-2 ABC transporter periplasmic autoinducer-2-binding protein LsrB YP_001743710.1 1643549 R 439855 CDS YP_001743711.1 170680972 6143198 complement(1644583..1645575) 1 NC_010498.1 identified by match to protein family HMM PF02653; autoinducer-2 ABC transporter permease LsrD 1645575 lsrD 6143198 lsrD Escherichia coli SMS-3-5 autoinducer-2 ABC transporter permease LsrD YP_001743711.1 1644583 R 439855 CDS YP_001743712.1 170681527 6145153 complement(1645575..1646603) 1 NC_010498.1 identified by match to protein family HMM PF02653; autoinducer-2 ABC transporter permease LsrC 1646603 lsrC 6145153 lsrC Escherichia coli SMS-3-5 autoinducer-2 ABC transporter permease LsrC YP_001743712.1 1645575 R 439855 CDS YP_001743713.1 170679722 6145712 complement(1646597..1648132) 1 NC_010498.1 identified by match to protein family HMM PF00005; autoinducer-2 ABC transporter ATP-binding protein LsrA 1648132 lsrA 6145712 lsrA Escherichia coli SMS-3-5 autoinducer-2 ABC transporter ATP-binding protein LsrA YP_001743713.1 1646597 R 439855 CDS YP_001743714.1 170680199 6143880 1648381..1649334 1 NC_010498.1 identified by match to protein family HMM PF04198; transcriptional repressor LsrR 1649334 lsrR 6143880 lsrR Escherichia coli SMS-3-5 transcriptional repressor LsrR YP_001743714.1 1648381 D 439855 CDS YP_001743715.1 170683577 6144365 1649413..1651005 1 NC_010498.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; autoinducer-2 (AI-2) kinase 1651005 lsrK 6144365 lsrK Escherichia coli SMS-3-5 autoinducer-2 (AI-2) kinase YP_001743715.1 1649413 D 439855 CDS YP_001743716.1 170684085 6142868 1651535..1656415 1 NC_010498.1 ydeK; identified by match to protein family HMM PF03212; match to protein family HMM TIGR02601; pertactin family protein 1656415 6142868 EcSMS35_1662 Escherichia coli SMS-3-5 pertactin family protein YP_001743716.1 1651535 D 439855 CDS YP_001743717.1 170682223 6143385 1656724..1656846 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1656846 6143385 EcSMS35_1663 Escherichia coli SMS-3-5 hypothetical protein YP_001743717.1 1656724 D 439855 CDS YP_001743718.1 170682216 6146422 1657614..1658177 1 NC_010498.1 identified by match to protein family HMM PF00419; fimbrial protein 1658177 6146422 EcSMS35_1664 Escherichia coli SMS-3-5 fimbrial protein YP_001743718.1 1657614 D 439855 CDS YP_001743719.1 170683705 6146415 1658540..1659250 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; periplasmic pilus chaperone family protein 1659250 6146415 EcSMS35_1665 Escherichia coli SMS-3-5 periplasmic pilus chaperone family protein YP_001743719.1 1658540 D 439855 CDS YP_001743720.1 170679788 6142997 1659328..1661943 1 NC_010498.1 identified by match to protein family HMM PF00577; fimbrial usher family protein 1661943 6142997 EcSMS35_1666 Escherichia coli SMS-3-5 fimbrial usher family protein YP_001743720.1 1659328 D 439855 CDS YP_001743721.1 170684138 6143948 1661957..1662487 1 NC_010498.1 identified by match to protein family HMM PF00419; protein FimF-like protein 1662487 6143948 EcSMS35_1667 Escherichia coli SMS-3-5 protein FimF-like protein YP_001743721.1 1661957 D 439855 CDS YP_001743722.1 170682655 6143438 1662500..1663147 1 NC_010498.1 ydeR; identified by similarity to SP:P08190; match to protein family HMM PF00419; protein FimG-like protein 1663147 6143438 EcSMS35_1669 Escherichia coli SMS-3-5 protein FimG-like protein YP_001743722.1 1662500 D 439855 CDS YP_001743723.1 170684099 6146862 complement(1662987..1663892) 1 NC_010498.1 identified by match to protein family HMM PF00665; IS2 transposase orfB 1663892 6146862 EcSMS35_1668 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001743723.1 1662987 R 439855 CDS YP_001743724.1 170683416 6143399 complement(1663850..1664260) 1 NC_010498.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1664260 6143399 EcSMS35_1670 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001743724.1 1663850 R 439855 CDS YP_001743725.1 170683036 6142702 1664399..1665313 1 NC_010498.1 identified by match to protein family HMM PF00419; match to protein family HMM PF09160; protein FimH-like protein 1665313 6142702 EcSMS35_1671 Escherichia coli SMS-3-5 protein FimH-like protein YP_001743725.1 1664399 D 439855 CDS YP_001743726.1 170682379 6147252 1665652..1667931 1 NC_010498.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase 1667931 6147252 EcSMS35_1672 Escherichia coli SMS-3-5 putative oxidoreductase YP_001743726.1 1665652 D 439855 CDS YP_001743727.1 170680802 6146578 1668179..1668376 1 NC_010498.1 identified by similarity to SP:Q7UCH6; hypothetical protein 1668376 6146578 EcSMS35_1673 Escherichia coli SMS-3-5 hypothetical protein YP_001743727.1 1668179 D 439855 CDS YP_001743728.1 170680428 6144978 1668451..1669212 1 NC_010498.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1669212 6144978 EcSMS35_1674 Escherichia coli SMS-3-5 transcriptional regulator YdeO YP_001743728.1 1668451 D 439855 CDS YP_001743729.1 170679774 6144597 1669676..1671295 1 NC_010498.1 identified by match to protein family HMM PF00884; sulfatase 1671295 6144597 EcSMS35_1675 Escherichia coli SMS-3-5 sulfatase YP_001743729.1 1669676 D 439855 CDS YP_001743730.1 170682242 6143933 1671347..1672504 1 NC_010498.1 identified by match to protein family HMM PF04055; radical SAM domain-containing protein 1672504 6143933 EcSMS35_1676 Escherichia coli SMS-3-5 radical SAM domain-containing protein YP_001743730.1 1671347 D 439855 CDS YP_001743731.1 170682224 6146441 1672795..1674480 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF05992; match to protein family HMM PF06472; inner membrane ABC transporter ATP-binding protein 1674480 6146441 EcSMS35_1677 Escherichia coli SMS-3-5 inner membrane ABC transporter ATP-binding protein YP_001743731.1 1672795 D 439855 CDS YP_001743732.1 170681386 6146423 1674518..1676890 1 NC_010498.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1676890 6146423 EcSMS35_1678 Escherichia coli SMS-3-5 TonB-dependent receptor YP_001743732.1 1674518 D 439855 CDS YP_001743733.1 170681032 6145570 1676947..1679730 1 NC_010498.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16B family peptidase 1679730 pqqL 6145570 pqqL Escherichia coli SMS-3-5 M16B family peptidase YP_001743733.1 1676947 D 439855 CDS YP_001743734.1 170680042 6145213 1680092..1681492 1 NC_010498.1 identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; glutamate decarboxylase GadA 1681492 gadA 6145213 gadA Escherichia coli SMS-3-5 glutamate decarboxylase GadA YP_001743734.1 1680092 D 439855 CDS YP_001743735.1 170679725 6144205 1681648..1683183 1 NC_010498.1 identified by match to protein family HMM PF00324; match to protein family HMM TIGR00910; glutamate:gamma aminobutyrate antiporter 1683183 gadC 6144205 gadC Escherichia coli SMS-3-5 glutamate:gamma aminobutyrate antiporter YP_001743735.1 1681648 D 439855 CDS YP_001743736.1 170683453 6143883 1683419..1684633 1 NC_010498.1 identified by match to protein family HMM PF02638; putative lipoprotein 1684633 6143883 EcSMS35_1682 Escherichia coli SMS-3-5 putative lipoprotein YP_001743736.1 1683419 D 439855 CDS YP_001743737.1 170683103 6142740 1685009..1686391 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1686391 6142740 EcSMS35_1683 Escherichia coli SMS-3-5 diguanylate cyclase YP_001743737.1 1685009 D 439855 CDS YP_001743738.1 170683445 6147322 1686392..1688815 1 NC_010498.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1688815 dos 6147322 dos Escherichia coli SMS-3-5 cAMP phosphodiesterase YP_001743738.1 1686392 D 439855 CDS YP_001743739.1 170680875 6142732 1689073..1689654 1 NC_010498.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1689654 ddpX 6142732 ddpX Escherichia coli SMS-3-5 D-alanyl-D-alanine dipeptidase YP_001743739.1 1689073 D 439855 CDS YP_001743740.1 170681069 6145053 1689668..1691218 1 NC_010498.1 identified by match to protein family HMM PF00496; putative ABC transporter periplasmic-binding protein yddS precursor 1691218 6145053 EcSMS35_1686 Escherichia coli SMS-3-5 putative ABC transporter periplasmic-binding protein yddS precursor YP_001743740.1 1689668 D 439855 CDS YP_001743741.1 170681904 6145251 1691220..1692242 1 NC_010498.1 identified by match to protein family HMM PF00528; inner membrane ABC transporter permease yddR 1692242 yddR 6145251 yddR Escherichia coli SMS-3-5 inner membrane ABC transporter permease yddR YP_001743741.1 1691220 D 439855 CDS YP_001743742.1 170681230 6146099 1692239..1693135 1 NC_010498.1 identified by match to protein family HMM PF00528; ATP-dependent peptide transporter membrane subunit 1693135 yddQ 6146099 yddQ Escherichia coli SMS-3-5 ATP-dependent peptide transporter membrane subunit YP_001743742.1 1692239 D 439855 CDS YP_001743743.1 170681718 6145414 1693132..1694118 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; ABC transporter ATP-binding protein 1694118 6145414 EcSMS35_1689 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001743743.1 1693132 D 439855 CDS YP_001743744.1 170680211 6145906 1694111..1695037 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; putative ABC transport system ATP-binding protein 1695037 6145906 EcSMS35_1690 Escherichia coli SMS-3-5 putative ABC transport system ATP-binding protein YP_001743744.1 1694111 D 439855 CDS YP_001743745.1 170680714 6144377 complement(1695093..1695443) 1 NC_010498.1 identified by match to protein family HMM PF02566; peroxiredoxin OsmC 1695443 osmC 6144377 osmC Escherichia coli SMS-3-5 peroxiredoxin OsmC YP_001743745.1 1695093 R 439855 CDS YP_001743746.1 170683270 6144889 complement(1695561..1695701) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1695701 6144889 EcSMS35_1692 Escherichia coli SMS-3-5 hypothetical protein YP_001743746.1 1695561 R 439855 CDS YP_001743747.1 170683795 6147495 1695868..1696083 1 NC_010498.1 biofilm-dependent modulation protein 1696083 6147495 EcSMS35_1693 Escherichia coli SMS-3-5 biofilm-dependent modulation protein YP_001743747.1 1695868 D 439855 CDS YP_001743748.1 170682250 6143088 1696185..1696322 1 NC_010498.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 1696322 rpsV 6143088 rpsV Escherichia coli SMS-3-5 30S ribosomal subunit S22 YP_001743748.1 1696185 D 439855 CDS YP_001743749.1 170682113 6146449 1696479..1698176 1 NC_010498.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1698176 sfcA 6146449 sfcA Escherichia coli SMS-3-5 malate dehydrogenase YP_001743749.1 1696479 D 439855 CDS YP_001743750.1 170681593 6146311 1698310..1699320 1 NC_010498.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1699320 6146311 EcSMS35_1696 Escherichia coli SMS-3-5 alcohol dehydrogenase YP_001743750.1 1698310 D 439855 CDS YP_001743751.1 170680944 6145778 1699466..1699750 1 NC_010498.1 identified by match to protein family HMM PF01381; match to protein family HMM TIGR02607; addiction module antidote protein 1699750 6145778 EcSMS35_1697 Escherichia coli SMS-3-5 addiction module antidote protein YP_001743751.1 1699466 D 439855 CDS YP_001743752.1 170682255 6145125 complement(1699801..1700454) 1 NC_010498.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1700454 fdnI 6145125 fdnI Escherichia coli SMS-3-5 formate dehydrogenase-N subunit gamma YP_001743752.1 1699801 R 439855 CDS YP_001743753.1 170681880 6146454 complement(1700447..1701331) 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582; formate dehydrogenase, nitrate-inducible, iron-sulfur subunit 1701331 fdnH 6146454 fdnH Escherichia coli SMS-3-5 formate dehydrogenase, nitrate-inducible, iron-sulfur subunit YP_001743753.1 1700447 R 439855 CDS YP_001743754.1 170684244 6146074 complement(1701344..1704391) 1 NC_010498.1 Selenoprotein. identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; formate dehydrogenase, nitrate inducible, alpha subunit, selenocysteine-containing 1704391 fdnG 6146074 fdnG Escherichia coli SMS-3-5 formate dehydrogenase, nitrate inducible, alpha subunit, selenocysteine-containing YP_001743754.1 1701344 R 439855 CDS YP_001743755.1 170680186 6143545 1704623..1705504 1 NC_010498.1 identified by match to protein family HMM PF00892; hypothetical protein 1705504 6143545 EcSMS35_1701 Escherichia coli SMS-3-5 hypothetical protein YP_001743755.1 1704623 D 439855 CDS YP_001743756.1 170679684 6144352 1705762..1706862 1 NC_010498.1 identified by similarity to SP:P77747; match to protein family HMM PF00267; porin family protein 1706862 6144352 EcSMS35_1702 Escherichia coli SMS-3-5 porin family protein YP_001743756.1 1705762 D 439855 CDS YP_001743757.1 170680907 6143842 1707032..1708291 1 NC_010498.1 identified by similarity to GB:ABB61785.1; hypothetical protein 1708291 6143842 EcSMS35_1703 Escherichia coli SMS-3-5 hypothetical protein YP_001743757.1 1707032 D 439855 CDS YP_001743758.1 170683898 6145086 1708354..1709610 1 NC_010498.1 identified by similarity to RF:NP_837403.1; hypothetical protein 1709610 6145086 EcSMS35_1704 Escherichia coli SMS-3-5 hypothetical protein YP_001743758.1 1708354 D 439855 CDS YP_001743759.1 170682066 6143194 1709920..1711308 1 NC_010498.1 identified by similarity to SP:P37758; match to protein family HMM PF07690; match to protein family HMM TIGR00886; nitrite extrusion protein 2 1711308 narU 6143194 narU Escherichia coli SMS-3-5 nitrite extrusion protein 2 YP_001743759.1 1709920 D 439855 CDS YP_001743760.1 170682586 6146263 1711403..1715143 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; nitrate reductase 2, alpha subunit 1715143 narZ 6146263 narZ Escherichia coli SMS-3-5 nitrate reductase 2, alpha subunit YP_001743760.1 1711403 D 439855 CDS YP_001743761.1 170683492 6146791 1715140..1716684 1 NC_010498.1 identified by similarity to SP:P19318; match to protein family HMM TIGR01660; nitrate reductase 2, beta subunit 1716684 narY 6146791 narY Escherichia coli SMS-3-5 nitrate reductase 2, beta subunit YP_001743761.1 1715140 D 439855 CDS YP_001743762.1 170683975 6142781 1716684..1717379 1 NC_010498.1 identified by similarity to SP:P19317; match to protein family HMM PF02613; match to protein family HMM TIGR00684; nitrate reductase molybdenum cofactor assembly chaperone 2 1717379 narW 6142781 narW Escherichia coli SMS-3-5 nitrate reductase molybdenum cofactor assembly chaperone 2 YP_001743762.1 1716684 D 439855 CDS YP_001743763.1 170681973 6143272 1717376..1718056 1 NC_010498.1 identified by similarity to SP:P0AF32; match to protein family HMM PF02665; match to protein family HMM TIGR00351; respiratory nitrate reductase 2, gamma subunit 1718056 narV 6143272 narV Escherichia coli SMS-3-5 respiratory nitrate reductase 2, gamma subunit YP_001743763.1 1717376 D 439855 CDS YP_001743764.1 170682607 6146169 1718136..1719029 1 NC_010498.1 identified by match to protein family HMM PF02567; match to protein family HMM TIGR00654; hypothetical protein 1719029 6146169 EcSMS35_1710 Escherichia coli SMS-3-5 hypothetical protein YP_001743764.1 1718136 D 439855 CDS YP_001743765.1 170681423 6146812 complement(1719125..1719970) 1 NC_010498.1 identified by match to protein family HMM PF00797; N-hydroxyarylamine O-acetyltransferase 1719970 6146812 EcSMS35_1711 Escherichia coli SMS-3-5 N-hydroxyarylamine O-acetyltransferase YP_001743765.1 1719125 R 439855 CDS YP_001743766.1 170681909 6145607 1720145..1720714 1 NC_010498.1 identified by match to protein family HMM PF01613; flavin reductase domain-containing protein 1720714 6145607 EcSMS35_1712 Escherichia coli SMS-3-5 flavin reductase domain-containing protein YP_001743766.1 1720145 D 439855 CDS YP_001743767.1 170679957 6146104 complement(1720718..1720945) 1 NC_010498.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1720945 6146104 EcSMS35_1713 Escherichia coli SMS-3-5 4-oxalocrotonate tautomerase YP_001743767.1 1720718 R 439855 CDS YP_001743768.1 170683013 6144119 1721250..1723226 1 NC_010498.1 identified by match to protein family HMM PF00753; metallo-beta-lactamase family protein 1723226 6144119 EcSMS35_1714 Escherichia coli SMS-3-5 metallo-beta-lactamase family protein YP_001743768.1 1721250 D 439855 CDS YP_001743769.1 170684171 6147229 1723202..1723339 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1723339 6147229 EcSMS35_1715 Escherichia coli SMS-3-5 hypothetical protein YP_001743769.1 1723202 D 439855 CDS YP_001743770.1 170679992 6143472 1723321..1724370 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1724370 6143472 EcSMS35_1716 Escherichia coli SMS-3-5 diguanylate cyclase YP_001743770.1 1723321 D 439855 CDS YP_001743771.1 170679756 6144154 complement(1724371..1724988) 1 NC_010498.1 identified by similarity to GB:ABB62052.1; hypothetical protein 1724988 6144154 EcSMS35_1717 Escherichia coli SMS-3-5 hypothetical protein YP_001743771.1 1724371 R 439855 CDS YP_001743772.1 170681095 6143914 1725255..1726754 1 NC_010498.1 identified by match to protein family HMM PF00324; L-asparagine permease 1726754 ansP 6143914 ansP Escherichia coli SMS-3-5 L-asparagine permease YP_001743772.1 1725255 D 439855 CDS YP_001743773.1 170680680 6145277 complement(1726867..1727928) 1 NC_010498.1 hypothetical protein 1727928 6145277 EcSMS35_1719 Escherichia coli SMS-3-5 hypothetical protein YP_001743773.1 1726867 R 439855 CDS YP_001743774.1 170680750 6144855 1728170..1730272 1 NC_010498.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1730272 6144855 EcSMS35_1720 Escherichia coli SMS-3-5 TonB-dependent receptor YP_001743774.1 1728170 D 439855 CDS YP_001743775.1 170681762 6144925 complement(1730308..1730973) 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; putative DNA-binding transcriptional regulator 1730973 6144925 EcSMS35_1721 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001743775.1 1730308 R 439855 CDS YP_001743776.1 170682411 6145953 1730972..1731103 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1731103 6145953 EcSMS35_1722 Escherichia coli SMS-3-5 hypothetical protein YP_001743776.1 1730972 D 439855 CDS YP_001743777.1 170683824 6146610 1731072..1731197 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1731197 6146610 EcSMS35_1724 Escherichia coli SMS-3-5 hypothetical protein YP_001743777.1 1731072 D 439855 CDS YP_001743778.1 170682763 6143118 complement(1731172..1732209) 1 NC_010498.1 identified by match to protein family HMM PF00107; zinc-binding dehydrogenase family oxidoreductase 1732209 6143118 EcSMS35_1723 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001743778.1 1731172 R 439855 CDS YP_001743779.1 170680307 6146972 1732390..1732908 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 1732908 6146972 EcSMS35_1725 Escherichia coli SMS-3-5 acetyltransferase YP_001743779.1 1732390 D 439855 CDS YP_001743780.1 170679651 6144475 1732905..1733354 1 NC_010498.1 identified by match to protein family HMM PF04657; hypothetical protein 1733354 6144475 EcSMS35_1726 Escherichia coli SMS-3-5 hypothetical protein YP_001743780.1 1732905 D 439855 CDS YP_001743781.1 170681585 6143808 complement(1733355..1733588) 1 NC_010498.1 hypothetical protein 1733588 6143808 EcSMS35_1727 Escherichia coli SMS-3-5 hypothetical protein YP_001743781.1 1733355 R 439855 CDS YP_001743782.1 170681752 6145770 complement(1733674..1733922) 1 NC_010498.1 hypothetical protein 1733922 6145770 EcSMS35_1728 Escherichia coli SMS-3-5 hypothetical protein YP_001743782.1 1733674 R 439855 CDS YP_001743783.1 170682039 6145942 1734121..1734237 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1734237 6145942 EcSMS35_1730 Escherichia coli SMS-3-5 hypothetical protein YP_001743783.1 1734121 D 439855 CDS YP_001743784.1 170681515 6146236 complement(1734234..1735658) 1 NC_010498.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1735658 ydcW 6146236 ydcW Escherichia coli SMS-3-5 gamma-aminobutyraldehyde dehydrogenase YP_001743784.1 1734234 R 439855 CDS YP_001743785.1 170682582 6145700 complement(1735680..1736474) 1 NC_010498.1 identified by match to protein family HMM PF00528; ABC transporter permease 1736474 ydcV 6145700 ydcV Escherichia coli SMS-3-5 ABC transporter permease YP_001743785.1 1735680 R 439855 CDS YP_001743786.1 170683660 6146787 complement(1736464..1737405) 1 NC_010498.1 identified by match to protein family HMM PF00528; ABC transporter permease 1737405 ydcU 6146787 ydcU Escherichia coli SMS-3-5 ABC transporter permease YP_001743786.1 1736464 R 439855 CDS YP_001743787.1 170680113 6142952 complement(1737406..1738419) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08402; ABC transporter ATP-binding protein 1738419 ydcT 6142952 ydcT Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001743787.1 1737406 R 439855 CDS YP_001743788.1 170681458 6144278 complement(1738437..1739582) 1 NC_010498.1 identified by match to protein family HMM PF01547; ABC transporter periplasmic substrate-binding protein 1739582 ydcS 6144278 ydcS Escherichia coli SMS-3-5 ABC transporter periplasmic substrate-binding protein YP_001743788.1 1738437 R 439855 CDS YP_001743789.1 170682466 6145643 complement(1739827..1741233) 1 NC_010498.1 identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator 1741233 6145643 EcSMS35_1735 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001743789.1 1739827 R 439855 CDS YP_001743790.1 170682851 6146665 complement(1741312..1741749) 1 NC_010498.1 identified by match to protein family HMM PF01381; match to protein family HMM PF03681; hypothetical protein 1741749 6146665 EcSMS35_1736 Escherichia coli SMS-3-5 hypothetical protein YP_001743790.1 1741312 R 439855 CDS YP_001743791.1 170681116 6147064 1741993..1742115 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1742115 6147064 EcSMS35_1737 Escherichia coli SMS-3-5 hypothetical protein YP_001743791.1 1741993 D 439855 CDS YP_001743792.1 170681462 6145299 1742232..1742402 1 NC_010498.1 hypothetical protein 1742402 6145299 EcSMS35_1738 Escherichia coli SMS-3-5 hypothetical protein YP_001743792.1 1742232 D 439855 CDS YP_001743793.1 170680392 6145647 complement(1742494..1744455) 1 NC_010498.1 identified by match to protein family HMM PF01136; U32 family peptidase 1744455 6145647 EcSMS35_1739 Escherichia coli SMS-3-5 U32 family peptidase YP_001743793.1 1742494 R 439855 CDS YP_001743794.1 170680755 6144561 complement(1744528..1745064) 1 NC_010498.1 identified by match to protein family HMM PF01381; match to protein family HMM PF07883; DNA-binding protein 1745064 6144561 EcSMS35_1740 Escherichia coli SMS-3-5 DNA-binding protein YP_001743794.1 1744528 R 439855 CDS YP_001743795.1 170684188 6144930 1745063..1746055 1 NC_010498.1 identified by match to protein family HMM PF03594; match to protein family HMM TIGR00843; benzoate transporter 1746055 6144930 EcSMS35_1742 Escherichia coli SMS-3-5 benzoate transporter YP_001743795.1 1745063 D 439855 CDS YP_001743796.1 170683807 6143489 complement(1746052..1747380) 1 NC_010498.1 identified by match to protein family HMM PF01609; IS4 transposase 1747380 6143489 EcSMS35_1741 Escherichia coli SMS-3-5 IS4 transposase YP_001743796.1 1746052 R 439855 CDS YP_001743797.1 170683107 6143101 1747487..1747765 1 NC_010498.1 identified by match to protein family HMM PF03594; benzoate membrane transport protein 1747765 6143101 EcSMS35_1743 Escherichia coli SMS-3-5 benzoate membrane transport protein YP_001743797.1 1747487 D 439855 CDS YP_001743798.1 170680356 6147326 complement(1747800..1748468) 1 NC_010498.1 putative lipoprotein 1748468 6147326 EcSMS35_1744 Escherichia coli SMS-3-5 putative lipoprotein YP_001743798.1 1747800 R 439855 CDS YP_001743799.1 170680992 6144524 complement(1748771..1749364) 1 NC_010498.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1749364 tehB 6144524 tehB Escherichia coli SMS-3-5 tellurite resistance protein TehB YP_001743799.1 1748771 R 439855 CDS YP_001743800.1 170682405 6145173 complement(1749361..1750353) 1 NC_010498.1 identified by match to protein family HMM PF03595; match to protein family HMM TIGR00816; potassium-tellurite ethidium and proflavin transporter 1750353 tehA 6145173 tehA Escherichia coli SMS-3-5 potassium-tellurite ethidium and proflavin transporter YP_001743800.1 1749361 R 439855 CDS YP_001743801.1 170680166 6146604 1750477..1751457 1 NC_010498.1 hypothetical protein 1751457 6146604 EcSMS35_1748 Escherichia coli SMS-3-5 hypothetical protein YP_001743801.1 1750477 D 439855 CDS YP_001743802.1 170679791 6144332 complement(1751449..1751988) 1 NC_010498.1 identified by match to protein family HMM PF00583; ribosomal-protein-L7/L12-serine acetyltransferase 1751988 rimL 6144332 rimL Escherichia coli SMS-3-5 ribosomal-protein-L7/L12-serine acetyltransferase YP_001743802.1 1751449 R 439855 CDS YP_001743803.1 170684128 6143951 complement(1752051..1752275) 1 NC_010498.1 identified by match to protein family HMM PF04325; hypothetical protein 1752275 6143951 EcSMS35_1749 Escherichia coli SMS-3-5 hypothetical protein YP_001743803.1 1752051 R 439855 CDS YP_001743804.1 170679744 6143428 complement(1752415..1754034) 1 NC_010498.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1754034 mdoD 6143428 mdoD Escherichia coli SMS-3-5 glucan biosynthesis protein D YP_001743804.1 1752415 R 439855 CDS YP_001743805.1 170683072 6143902 complement(1754295..1755638) 1 NC_010498.1 identified by match to protein family HMM PF07063; hypothetical protein 1755638 6143902 EcSMS35_1751 Escherichia coli SMS-3-5 hypothetical protein YP_001743805.1 1754295 R 439855 CDS YP_001743806.1 170683406 6147289 1755855..1756778 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1756778 6147289 EcSMS35_1752 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743806.1 1755855 D 439855 CDS YP_001743807.1 170682410 6142692 complement(1756817..1758457) 1 NC_010498.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein III 1758457 trg 6142692 trg Escherichia coli SMS-3-5 methyl-accepting chemotaxis protein III YP_001743807.1 1756817 R 439855 CDS YP_001743808.1 170683936 6146609 complement(1759077..1759250) 1 NC_010498.1 hypothetical protein 1759250 6146609 EcSMS35_1754 Escherichia coli SMS-3-5 hypothetical protein YP_001743808.1 1759077 R 439855 CDS YP_001743809.1 170679749 6143232 complement(1759495..1760061) 1 NC_010498.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1760061 6143232 EcSMS35_1755 Escherichia coli SMS-3-5 cytochrome b561 YP_001743809.1 1759495 R 439855 CDS YP_001743810.1 170680304 6143907 1760214..1761215 1 NC_010498.1 identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1761215 gapC 6143907 gapC Escherichia coli SMS-3-5 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) YP_001743810.1 1760214 D 439855 CDS YP_001743811.1 170680762 6144472 complement(1761256..1762695) 1 NC_010498.1 NAD-linked; aldehyde dehydrogenase A 1762695 aldA 6144472 aldA Escherichia coli SMS-3-5 aldehyde dehydrogenase A YP_001743811.1 1761256 R 439855 CDS YP_001743812.1 170681330 6144937 complement(1762892..1763692) 1 NC_010498.1 identified by match to protein family HMM PF02698; hypothetical protein 1763692 6144937 EcSMS35_1758 Escherichia coli SMS-3-5 hypothetical protein YP_001743812.1 1762892 R 439855 CDS YP_001743813.1 170684173 6145514 complement(1763965..1767867) 1 NC_010498.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1767867 hrpA 6145514 hrpA Escherichia coli SMS-3-5 ATP-dependent RNA helicase HrpA YP_001743813.1 1763965 R 439855 CDS YP_001743814.1 170682348 6143474 1768068..1768673 1 NC_010498.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1768673 azoR 6143474 azoR Escherichia coli SMS-3-5 azoreductase YP_001743814.1 1768068 D 439855 CDS YP_001743815.1 170680460 6146547 complement(1768727..1770019) 1 NC_010498.1 identified by match to protein family HMM PF00782; match to protein family HMM PF01569; PAP2 family protein 1770019 6146547 EcSMS35_1761 Escherichia coli SMS-3-5 PAP2 family protein YP_001743815.1 1768727 R 439855 CDS YP_001743816.1 170683337 6144629 complement(1770033..1771790) 1 NC_010498.1 hypothetical protein 1771790 6144629 EcSMS35_1762 Escherichia coli SMS-3-5 hypothetical protein YP_001743816.1 1770033 R 439855 CDS YP_001743817.1 170681478 6142622 complement(1771806..1772702) 1 NC_010498.1 identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 1772702 cdsA2 6142622 cdsA2 Escherichia coli SMS-3-5 phosphatidate cytidylyltransferase YP_001743817.1 1771806 R 439855 CDS YP_001743818.1 170680517 6145663 complement(1772702..1773307) 1 NC_010498.1 identified by match to protein family HMM PF01066; CDP-alcohol phosphatidyltransferase family protein 1773307 6145663 EcSMS35_1764 Escherichia coli SMS-3-5 CDP-alcohol phosphatidyltransferase family protein YP_001743818.1 1772702 R 439855 CDS YP_001743819.1 170682391 6144687 complement(1773477..1775783) 1 NC_010498.1 hypothetical protein 1775783 6144687 EcSMS35_1765 Escherichia coli SMS-3-5 hypothetical protein YP_001743819.1 1773477 R 439855 CDS YP_001743820.1 170683747 6146590 complement(1775847..1776707) 1 NC_010498.1 identified by match to protein family HMM PF00248; putative oxidoreductase 1776707 6146590 EcSMS35_1766 Escherichia coli SMS-3-5 putative oxidoreductase YP_001743820.1 1775847 R 439855 CDS YP_001743821.1 170680870 6143039 complement(1776915..1782869) 1 NC_010498.1 identified by match to protein family HMM PF03797; putative autotransporter 1782869 6143039 EcSMS35_1767 Escherichia coli SMS-3-5 putative autotransporter YP_001743821.1 1776915 R 439855 CDS YP_001743822.1 170682611 6145048 complement(1783327..1783650) 1 NC_010498.1 identified by similarity to GB:CAD01687.1; match to protein family HMM PF07027; hypothetical protein 1783650 6145048 EcSMS35_1768 Escherichia coli SMS-3-5 hypothetical protein YP_001743822.1 1783327 R 439855 CDS YP_001743823.1 170679825 6146816 complement(1783658..1783843) 1 NC_010498.1 putative lipoprotein 1783843 6146816 EcSMS35_1769 Escherichia coli SMS-3-5 putative lipoprotein YP_001743823.1 1783658 R 439855 CDS YP_001743824.1 170681090 6143987 complement(1783840..1786479) 1 NC_010498.1 hypothetical protein 1786479 6143987 EcSMS35_1770 Escherichia coli SMS-3-5 hypothetical protein YP_001743824.1 1783840 R 439855 CDS YP_001743825.1 170680565 6145272 1786687..1787676 1 NC_010498.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826; D-lactate dehydrogenase 1787676 idhA 6145272 idhA Escherichia coli SMS-3-5 D-lactate dehydrogenase YP_001743825.1 1786687 D 439855 CDS YP_001743826.1 170683701 6144735 1787787..1788209 1 NC_010498.1 identified by match to protein family HMM PF03724; heat-inducible protein 1788209 hslJ 6144735 hslJ Escherichia coli SMS-3-5 heat-inducible protein YP_001743826.1 1787787 D 439855 CDS YP_001743827.1 170680086 6142993 complement(1788206..1788331) 1 NC_010498.1 putative lipoprotein 1788331 6142993 EcSMS35_1772 Escherichia coli SMS-3-5 putative lipoprotein YP_001743827.1 1788206 R 439855 CDS YP_001743828.1 170680142 6144250 1788559..1788675 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1788675 6144250 EcSMS35_1774 Escherichia coli SMS-3-5 hypothetical protein YP_001743828.1 1788559 D 439855 CDS YP_001743829.1 170683269 6144308 1788746..1792270 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176; pyruvate-flavodoxin oxidoreductase 1792270 ydbK 6144308 ydbK Escherichia coli SMS-3-5 pyruvate-flavodoxin oxidoreductase YP_001743829.1 1788746 D 439855 CDS YP_001743830.1 170680275 6147494 1792636..1793754 1 NC_010498.1 identified by similarity to SP:P77747; match to protein family HMM PF00267; outer membrane protein N 1793754 ompN 6147494 ompN Escherichia coli SMS-3-5 outer membrane protein N YP_001743830.1 1792636 D 439855 CDS YP_001743831.1 170682301 6144442 1793895..1794329 1 NC_010498.1 identified by match to protein family HMM PF00582; universal stress protein F 1794329 uspF 6144442 uspF Escherichia coli SMS-3-5 universal stress protein F YP_001743831.1 1793895 D 439855 CDS YP_001743832.1 170683989 6146500 1794505..1795440 1 NC_010498.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1795440 6146500 EcSMS35_1778 Escherichia coli SMS-3-5 C32 tRNA thiolase YP_001743832.1 1794505 D 439855 CDS YP_001743833.1 170681328 6143287 complement(1795569..1796942) 1 NC_010498.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1796942 dbpA 6143287 dbpA Escherichia coli SMS-3-5 ATP-dependent RNA helicase DbpA YP_001743833.1 1795569 R 439855 CDS YP_001743834.1 170682997 6145512 complement(1797420..1798403) 1 NC_010498.1 identified by match to protein family HMM PF01544; zinc transporter 1798403 zntB 6145512 zntB Escherichia coli SMS-3-5 zinc transporter YP_001743834.1 1797420 R 439855 CDS YP_001743835.1 170681443 6147213 1798598..1799890 1 NC_010498.1 identified by match to protein family HMM PF00990; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254; sensory box-containing diguanylate cyclase 1799890 6147213 EcSMS35_1781 Escherichia coli SMS-3-5 sensory box-containing diguanylate cyclase YP_001743835.1 1798598 D 439855 CDS YP_001743836.1 170680790 6145628 complement(1799911..1800474) 1 NC_010498.1 identified by match to protein family HMM PF01713; Smr domain-containing protein 1800474 6145628 EcSMS35_1782 Escherichia coli SMS-3-5 Smr domain-containing protein YP_001743836.1 1799911 R 439855 CDS YP_001743837.1 170682963 6144965 complement(1800805..1801713) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 1801713 abgR 6144965 abgR Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001743837.1 1800805 R 439855 CDS YP_001743838.1 170679911 6147178 1801898..1803199 1 NC_010498.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; aminobenzoyl-glutamate utilization protein A 1803199 abgA 6147178 abgA Escherichia coli SMS-3-5 aminobenzoyl-glutamate utilization protein A YP_001743838.1 1801898 D 439855 CDS YP_001743839.1 170682636 6144073 1803199..1804644 1 NC_010498.1 identified by match to protein family HMM PF01546; match to protein family HMM TIGR01891; aminobenzoyl-glutamate utilization protein B 1804644 abgB 6144073 abgB Escherichia coli SMS-3-5 aminobenzoyl-glutamate utilization protein B YP_001743839.1 1803199 D 439855 CDS YP_001743840.1 170683317 6146842 1804675..1806207 1 NC_010498.1 identified by match to protein family HMM PF03806; match to protein family HMM TIGR00819; putative aminobenzoyl-glutamate transporter 1806207 abgT 6146842 abgT Escherichia coli SMS-3-5 putative aminobenzoyl-glutamate transporter YP_001743840.1 1804675 D 439855 CDS YP_001743841.1 170681861 6142602 1806218..1806733 1 NC_010498.1 identified by match to protein family HMM PF01035; match to protein family HMM PF02870; match to protein family HMM TIGR00589; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1806733 ogt 6142602 ogt Escherichia coli SMS-3-5 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_001743841.1 1806218 D 439855 CDS YP_001743842.1 170681933 6146055 1806928..1807680 1 NC_010498.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1807680 fnr 6146055 fnr Escherichia coli SMS-3-5 fumarate/nitrate reduction transcriptional regulator YP_001743842.1 1806928 D 439855 CDS YP_001743843.1 170681219 6146129 1807832..1808782 1 NC_010498.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1808782 uspE 6146129 uspE Escherichia coli SMS-3-5 universal stress protein UspE YP_001743843.1 1807832 D 439855 CDS YP_001743844.1 170681889 6145403 complement(1808832..1809089) 1 NC_010498.1 hypothetical protein 1809089 6145403 EcSMS35_1790 Escherichia coli SMS-3-5 hypothetical protein YP_001743844.1 1808832 R 439855 CDS YP_001743845.1 170679888 6146083 1809333..1810364 1 NC_010498.1 identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel family protein 1810364 6146083 EcSMS35_1791 Escherichia coli SMS-3-5 small conductance mechanosensitive ion channel family protein YP_001743845.1 1809333 D 439855 CDS YP_001743846.1 170680564 6144050 complement(1810415..1812028) 1 NC_010498.1 identified by match to protein family HMM PF00496; periplasmic murein peptide-binding protein 1812028 mppA 6144050 mppA Escherichia coli SMS-3-5 periplasmic murein peptide-binding protein YP_001743846.1 1810415 R 439855 CDS YP_001743847.1 170681201 6144734 complement(1812365..1813264) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1813264 6144734 EcSMS35_1793 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001743847.1 1812365 R 439855 CDS YP_001743848.1 170681250 6145385 1813402..1814322 1 NC_010498.1 identified by match to protein family HMM PF02129; hypothetical protein 1814322 6145385 EcSMS35_1794 Escherichia coli SMS-3-5 hypothetical protein YP_001743848.1 1813402 D 439855 CDS YP_001743849.1 170681263 6145434 1814393..1815031 1 NC_010498.1 identified by match to protein family HMM PF05368; NmrA family protein 1815031 6145434 EcSMS35_1795 Escherichia coli SMS-3-5 NmrA family protein YP_001743849.1 1814393 D 439855 CDS YP_001743850.1 170681942 6145447 1815322..1816050 1 NC_010498.1 identified by match to protein family HMM PF00246; murein peptide amidase A 1816050 6145447 EcSMS35_1797 Escherichia coli SMS-3-5 murein peptide amidase A YP_001743850.1 1815322 D 439855 CDS YP_001743851.1 170681912 6146138 complement(1816025..1816990) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein 1816990 6146138 EcSMS35_1796 Escherichia coli SMS-3-5 mandelate racemase/muconate lactonizing enzyme family protein YP_001743851.1 1816025 R 439855 CDS YP_001743852.1 170682639 6146107 1817109..1817615 1 NC_010498.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1817615 tpx 6146107 tpx Escherichia coli SMS-3-5 thiol peroxidase YP_001743852.1 1817109 D 439855 CDS YP_001743853.1 170681764 6146845 complement(1817659..1819200) 1 NC_010498.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1819200 tyrR 6146845 tyrR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator TyrR YP_001743853.1 1817659 R 439855 CDS YP_001743854.1 170681259 6145955 complement(1819348..1820409) 1 NC_010498.1 ycjF; identified by match to protein family HMM PF05128; match to protein family HMM TIGR01620; hypothetical protein 1820409 6145955 EcSMS35_1800 Escherichia coli SMS-3-5 hypothetical protein YP_001743854.1 1819348 R 439855 CDS YP_001743855.1 170682550 6145443 complement(1820406..1821803) 1 NC_010498.1 identified by match to protein family HMM PF04317; hypothetical protein 1821803 6145443 EcSMS35_1801 Escherichia coli SMS-3-5 hypothetical protein YP_001743855.1 1820406 R 439855 CDS YP_001743856.1 170682008 6146752 1821947..1822945 1 NC_010498.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcription regulator 1822945 6146752 EcSMS35_1802 Escherichia coli SMS-3-5 LacI family transcription regulator YP_001743856.1 1821947 D 439855 CDS YP_001743857.1 170683200 6146205 complement(1822996..1823901) 1 NC_010498.1 identified by similarity to SP:P76045; monomeric porin OmpG 1823901 ompG 6146205 ompG Escherichia coli SMS-3-5 monomeric porin OmpG YP_001743857.1 1822996 R 439855 CDS YP_001743858.1 170680817 6147420 complement(1823946..1825028) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; sugar ABC transporter ATP-binding protein 1825028 6147420 EcSMS35_1804 Escherichia coli SMS-3-5 sugar ABC transporter ATP-binding protein YP_001743858.1 1823946 R 439855 CDS YP_001743859.1 170682001 6144993 complement(1825042..1825701) 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR01990; match to protein family HMM TIGR02009; beta-phosphoglucomutase 1825701 pgmB 6144993 pgmB Escherichia coli SMS-3-5 beta-phosphoglucomutase YP_001743859.1 1825042 R 439855 CDS YP_001743860.1 170682507 6146197 complement(1825698..1827965) 1 NC_010498.1 identified by match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636; glycosyl hydrolase family protein 1827965 6146197 EcSMS35_1806 Escherichia coli SMS-3-5 glycosyl hydrolase family protein YP_001743860.1 1825698 R 439855 CDS YP_001743861.1 170684205 6146707 complement(1827962..1829005) 1 NC_010498.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894; gfo/idh/mocA family protein 1829005 6146707 EcSMS35_1807 Escherichia coli SMS-3-5 gfo/idh/mocA family protein YP_001743861.1 1827962 R 439855 CDS YP_001743862.1 170683456 6143506 complement(1829027..1829815) 1 NC_010498.1 identified by match to protein family HMM PF01261; AP endonuclease 1829815 6143506 EcSMS35_1808 Escherichia coli SMS-3-5 AP endonuclease YP_001743862.1 1829027 R 439855 CDS YP_001743863.1 170681445 6142743 complement(1829833..1830885) 1 NC_010498.1 identified by match to protein family HMM PF00107; zinc-binding dehydrogenase family oxidoreductase 1830885 6142743 EcSMS35_1809 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001743863.1 1829833 R 439855 CDS YP_001743864.1 170682092 6145630 complement(1830916..1831758) 1 NC_010498.1 identified by match to protein family HMM PF00528; putative sugar ABC transporter permease 1831758 6145630 EcSMS35_1810 Escherichia coli SMS-3-5 putative sugar ABC transporter permease YP_001743864.1 1830916 R 439855 CDS YP_001743865.1 170682754 6146289 complement(1831745..1832626) 1 NC_010498.1 identified by match to protein family HMM PF00528; putative sugar ABC transporter permease 1832626 6146289 EcSMS35_1811 Escherichia coli SMS-3-5 putative sugar ABC transporter permease YP_001743865.1 1831745 R 439855 CDS YP_001743866.1 170683434 6146963 complement(1832647..1833939) 1 NC_010498.1 identified by match to protein family HMM PF01547; putative sugar ABC transporter periplasmic sugar-binding protein 1833939 6146963 EcSMS35_1812 Escherichia coli SMS-3-5 putative sugar ABC transporter periplasmic sugar-binding protein YP_001743866.1 1832647 R 439855 CDS YP_001743867.1 170679871 6142721 complement(1833953..1835632) 1 NC_010498.1 identified by match to protein family HMM PF00128; alpha amylase family protein 1835632 6142721 EcSMS35_1813 Escherichia coli SMS-3-5 alpha amylase family protein YP_001743867.1 1833953 R 439855 CDS YP_001743868.1 170682062 6144033 complement(1835846..1836160) 1 NC_010498.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1836160 pspE 6144033 pspE Escherichia coli SMS-3-5 thiosulfate:cyanide sulfurtransferase YP_001743868.1 1835846 R 439855 CDS YP_001743869.1 170683517 6146259 complement(1836235..1836456) 1 NC_010498.1 identified by match to protein family HMM TIGR02979; peripheral inner membrane phage-shock protein 1836456 pspD 6146259 pspD Escherichia coli SMS-3-5 peripheral inner membrane phage-shock protein YP_001743869.1 1836235 R 439855 CDS YP_001743870.1 170684285 6142807 complement(1836465..1836824) 1 NC_010498.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1836824 pspC 6142807 pspC Escherichia coli SMS-3-5 DNA-binding transcriptional activator PspC YP_001743870.1 1836465 R 439855 CDS YP_001743871.1 170682840 6143587 complement(1836824..1837048) 1 NC_010498.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1837048 pspB 6143587 pspB Escherichia coli SMS-3-5 phage shock protein B YP_001743871.1 1836824 R 439855 CDS YP_001743872.1 170680978 6147051 complement(1837102..1837770) 1 NC_010498.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1837770 pspA 6147051 pspA Escherichia coli SMS-3-5 phage shock protein PspA YP_001743872.1 1837102 R 439855 CDS YP_001743873.1 170684159 6145159 1837937..1838914 1 NC_010498.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1838914 pspF 6145159 pspF Escherichia coli SMS-3-5 phage shock protein operon transcriptional activator YP_001743873.1 1837937 D 439855 CDS YP_001743874.1 170682308 6143459 complement(1839045..1840310) 1 NC_010498.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1840310 gabT1 6143459 gabT1 Escherichia coli SMS-3-5 4-aminobutyrate transaminase YP_001743874.1 1839045 R 439855 CDS YP_001743875.1 170679683 6146507 complement(1840348..1841628) 1 NC_010498.1 identified by match to protein family HMM PF01266; gamma-glutamylputrescine oxidoreductase 1841628 puuB 6146507 puuB Escherichia coli SMS-3-5 gamma-glutamylputrescine oxidoreductase YP_001743875.1 1840348 R 439855 CDS YP_001743876.1 170680173 6143841 complement(1841630..1843117) 1 NC_010498.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1843117 puuC 6143841 puuC Escherichia coli SMS-3-5 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_001743876.1 1841630 R 439855 CDS YP_001743877.1 170680966 6144339 complement(1843267..1843824) 1 NC_010498.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1843824 puuR 6144339 puuR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor PuuR YP_001743877.1 1843267 R 439855 CDS YP_001743878.1 170679609 6145147 complement(1843851..1844603) 1 NC_010498.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1844603 puuD 6145147 puuD Escherichia coli SMS-3-5 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_001743878.1 1843851 R 439855 CDS YP_001743879.1 170682225 6143766 1844827..1846245 1 NC_010498.1 identified by match to protein family HMM PF00120; glutamate--putrescine ligase 1846245 puuA 6143766 puuA Escherichia coli SMS-3-5 glutamate--putrescine ligase YP_001743879.1 1844827 D 439855 CDS YP_001743880.1 170682974 6146424 1846548..1847933 1 NC_010498.1 identified by match to protein family HMM PF00324; amino acid permease 1847933 6146424 EcSMS35_1826 Escherichia coli SMS-3-5 amino acid permease YP_001743880.1 1846548 D 439855 CDS YP_001743881.1 170683601 6147189 1848067..1848312 1 NC_010498.1 hypothetical protein 1848312 6147189 EcSMS35_1827 Escherichia coli SMS-3-5 hypothetical protein YP_001743881.1 1848067 D 439855 CDS YP_001743882.1 170684301 6142891 1848649..1850268 1 NC_010498.1 identified by match to protein family HMM PF00496; peptide ABC transporter periplasmic peptide-binding protein 1850268 sapA 6142891 sapA Escherichia coli SMS-3-5 peptide ABC transporter periplasmic peptide-binding protein YP_001743882.1 1848649 D 439855 CDS YP_001743883.1 170683242 6143603 1850265..1851230 1 NC_010498.1 identified by match to protein family HMM PF00528; peptide ABC transporter permease SapB 1851230 sapB 6143603 sapB Escherichia coli SMS-3-5 peptide ABC transporter permease SapB YP_001743883.1 1850265 D 439855 CDS YP_001743884.1 170684277 6147464 1851217..1852107 1 NC_010498.1 identified by match to protein family HMM PF00528; peptide ABC transporter permease SapC 1852107 sapC 6147464 sapC Escherichia coli SMS-3-5 peptide ABC transporter permease SapC YP_001743884.1 1851217 D 439855 CDS YP_001743885.1 170679617 6143579 1852107..1853099 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; peptide ABC transporter ATP-binding protein SapD 1853099 sapD 6143579 sapD Escherichia coli SMS-3-5 peptide ABC transporter ATP-binding protein SapD YP_001743885.1 1852107 D 439855 CDS YP_001743886.1 170680270 6143774 1853101..1853907 1 NC_010498.1 identified by similarity to SP:P36638; match to protein family HMM PF00005; peptide transport system, ATP-binding protein SapF 1853907 sapF 6143774 sapF Escherichia coli SMS-3-5 peptide transport system, ATP-binding protein SapF YP_001743886.1 1853101 D 439855 CDS YP_001743887.1 170680921 6144437 complement(1853956..1855119) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710; multidrug efflux transport protein EefD 1855119 eefD 6144437 eefD Escherichia coli SMS-3-5 multidrug efflux transport protein EefD YP_001743887.1 1853956 R 439855 CDS YP_001743888.1 170681888 6145102 complement(1855128..1856501) 1 NC_010498.1 identified by similarity to GB:CAD48863.1; match to protein family HMM PF02321; match to protein family HMM TIGR01845; multidrug efflux outer membrane protein EefC 1856501 eefC 6145102 eefC Escherichia coli SMS-3-5 multidrug efflux outer membrane protein EefC YP_001743888.1 1855128 R 439855 CDS YP_001743889.1 170683789 6146082 complement(1856505..1859612) 1 NC_010498.1 identified by similarity to GB:CAD48862.1; match to protein family HMM PF00873; match to protein family HMM TIGR00915; multidrug efflux transport protein EefB 1859612 eefB 6146082 eefB Escherichia coli SMS-3-5 multidrug efflux transport protein EefB YP_001743889.1 1856505 R 439855 CDS YP_001743890.1 170683115 6143081 complement(1859612..1860733) 1 NC_010498.1 identified by similarity to GB:CAD48861.1; match to protein family HMM PF00529; match to protein family HMM TIGR01730; multidrug efflux transport protein EefA 1860733 eefA 6143081 eefA Escherichia coli SMS-3-5 multidrug efflux transport protein EefA YP_001743890.1 1859612 R 439855 CDS YP_001743891.1 170681981 6147334 complement(1860882..1861448) 1 NC_010498.1 identified by match to protein family HMM PF00440; transcriptional regulator EefR 1861448 eefR 6147334 eefR Escherichia coli SMS-3-5 transcriptional regulator EefR YP_001743891.1 1860882 R 439855 CDS YP_001743892.1 170683953 6146177 complement(1861624..1861764) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1861764 6146177 EcSMS35_1838 Escherichia coli SMS-3-5 hypothetical protein YP_001743892.1 1861624 R 439855 CDS YP_001743893.1 170680950 6143250 1861926..1862714 1 NC_010498.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1862714 fabI 6143250 fabI Escherichia coli SMS-3-5 enoyl-(acyl carrier protein) reductase YP_001743893.1 1861926 D 439855 CDS YP_001743894.1 170682969 6145131 1862859..1863986 1 NC_010498.1 hypothetical protein 1863986 6145131 EcSMS35_1840 Escherichia coli SMS-3-5 hypothetical protein YP_001743894.1 1862859 D 439855 CDS YP_001743895.1 170681733 6147184 1864054..1865988 1 NC_010498.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1865988 rnb 6147184 rnb Escherichia coli SMS-3-5 exoribonuclease II YP_001743895.1 1864054 D 439855 CDS YP_001743896.1 170681077 6145922 1866223..1868208 1 NC_010498.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1868208 6145922 EcSMS35_1842 Escherichia coli SMS-3-5 RNase II stability modulator YP_001743896.1 1866223 D 439855 CDS YP_001743897.1 170680708 6145259 1868356..1868529 1 NC_010498.1 hypothetical protein 1868529 6145259 EcSMS35_1843 Escherichia coli SMS-3-5 hypothetical protein YP_001743897.1 1868356 D 439855 CDS YP_001743898.1 170683876 6144883 1868619..1869368 1 NC_010498.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator 1869368 6144883 EcSMS35_1844 Escherichia coli SMS-3-5 DeoR family transcriptional regulator YP_001743898.1 1868619 D 439855 CDS YP_001743899.1 170681513 6143171 1869637..1869855 1 NC_010498.1 lipoprotein 1869855 6143171 EcSMS35_1845 Escherichia coli SMS-3-5 lipoprotein YP_001743899.1 1869637 D 439855 CDS YP_001743900.1 170680982 6145698 complement(1869981..1870310) 1 NC_010498.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1870310 6145698 EcSMS35_1846 Escherichia coli SMS-3-5 translation initiation factor Sui1 YP_001743900.1 1869981 R 439855 CDS YP_001743901.1 170680162 6145163 complement(1870307..1871044) 1 NC_010498.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1871044 pyrF 6145163 pyrF Escherichia coli SMS-3-5 orotidine 5'-phosphate decarboxylase YP_001743901.1 1870307 R 439855 CDS YP_001743902.1 170679727 6144328 1871060..1871212 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1871212 6144328 EcSMS35_1848 Escherichia coli SMS-3-5 hypothetical protein YP_001743902.1 1871060 D 439855 CDS YP_001743903.1 170683676 6143885 complement(1871236..1872405) 1 NC_010498.1 identified by match to protein family HMM PF07719; tetratricopeptide repeat protein 1872405 6143885 EcSMS35_1849 Escherichia coli SMS-3-5 tetratricopeptide repeat protein YP_001743903.1 1871236 R 439855 CDS YP_001743904.1 170680512 6142968 complement(1872412..1872720) 1 NC_010498.1 identified by match to protein family HMM PF06305; hypothetical protein 1872720 6142968 EcSMS35_1850 Escherichia coli SMS-3-5 hypothetical protein YP_001743904.1 1872412 R 439855 CDS YP_001743905.1 170682357 6144682 complement(1872869..1873633) 1 NC_010498.1 identified by match to protein family HMM PF01569; phosphatidylglycerophosphatase B 1873633 pgpB 6144682 pgpB Escherichia coli SMS-3-5 phosphatidylglycerophosphatase B YP_001743905.1 1872869 R 439855 CDS YP_001743906.1 170683390 6146556 1873803..1874393 1 NC_010498.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1874393 ribA 6146556 ribA Escherichia coli SMS-3-5 GTP cyclohydrolase II YP_001743906.1 1873803 D 439855 CDS YP_001743907.1 170681003 6142676 complement(1874457..1877132) 1 NC_010498.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1877132 acnA 6142676 acnA Escherichia coli SMS-3-5 aconitate hydratase YP_001743907.1 1874457 R 439855 CDS YP_001743908.1 170681124 6145184 complement(1877452..1877619) 1 NC_010498.1 hypothetical protein 1877619 6145184 EcSMS35_1854 Escherichia coli SMS-3-5 hypothetical protein YP_001743908.1 1877452 R 439855 CDS YP_001743909.1 170680282 6145307 complement(1877622..1877750) 1 NC_010498.1 hypothetical protein 1877750 6145307 EcSMS35_1855 Escherichia coli SMS-3-5 hypothetical protein YP_001743909.1 1877622 R 439855 CDS YP_001743910.1 170679623 6144449 complement(1878081..1879055) 1 NC_010498.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1879055 cysB 6144449 cysB Escherichia coli SMS-3-5 transcriptional regulator CysB YP_001743910.1 1878081 R 439855 CDS YP_001743911.1 170682590 6143780 complement(1879264..1881861) 1 NC_010498.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1881861 topA 6143780 topA Escherichia coli SMS-3-5 DNA topoisomerase I YP_001743911.1 1879264 R 439855 CDS YP_001743912.1 170681925 6146795 1882241..1882492 1 NC_010498.1 hypothetical protein 1882492 6146795 EcSMS35_1858 Escherichia coli SMS-3-5 hypothetical protein YP_001743912.1 1882241 D 439855 CDS YP_001743913.1 170682481 6146121 complement(1882528..1883577) 1 NC_010498.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1883577 sohB 6146121 sohB Escherichia coli SMS-3-5 putative periplasmic protease YP_001743913.1 1882528 R 439855 CDS YP_001743914.1 170681806 6146680 1883797..1884555 1 NC_010498.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase 1884555 6146680 EcSMS35_1860 Escherichia coli SMS-3-5 short chain dehydrogenase YP_001743914.1 1883797 D 439855 CDS YP_001743915.1 170680960 6145999 1884552..1885142 1 NC_010498.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1885142 btuR 6145999 btuR Escherichia coli SMS-3-5 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_001743915.1 1884552 D 439855 CDS YP_001743916.1 170680559 6145141 complement(1885195..1885503) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1885503 6145141 EcSMS35_1862 Escherichia coli SMS-3-5 hypothetical protein YP_001743916.1 1885195 R 439855 CDS YP_001743917.1 170679656 6144729 complement(1885514..1886515) 1 NC_010498.1 putative lipoprotein 1886515 6144729 EcSMS35_1863 Escherichia coli SMS-3-5 putative lipoprotein YP_001743917.1 1885514 R 439855 CDS YP_001743918.1 170682451 6143814 complement(1886685..1887560) 1 NC_010498.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1887560 rluB 6143814 rluB Escherichia coli SMS-3-5 23S rRNA pseudouridylate synthase B YP_001743918.1 1886685 R 439855 CDS YP_001743919.1 170681982 6146650 complement(1887771..1889666) 1 NC_010498.1 hypothetical protein 1889666 6146650 EcSMS35_1865 Escherichia coli SMS-3-5 hypothetical protein YP_001743919.1 1887771 R 439855 CDS YP_001743920.1 170681810 6146178 complement(1889694..1890350) 1 NC_010498.1 identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; hypothetical protein 1890350 6146178 EcSMS35_1866 Escherichia coli SMS-3-5 hypothetical protein YP_001743920.1 1889694 R 439855 CDS YP_001743921.1 170681023 6146003 complement(1890311..1891192) 1 NC_010498.1 identified by match to protein family HMM PF02811; putative phosphoesterase 1891192 6146003 EcSMS35_1867 Escherichia coli SMS-3-5 putative phosphoesterase YP_001743921.1 1890311 R 439855 CDS YP_001743922.1 170680165 6145204 1891466..1893028 1 NC_010498.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1893028 trpE 6145204 trpE Escherichia coli SMS-3-5 anthranilate synthase component I YP_001743922.1 1891466 D 439855 CDS YP_001743923.1 170679698 6144331 1893028..1894623 1 NC_010498.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1894623 trpD 6144331 trpD Escherichia coli SMS-3-5 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_001743923.1 1893028 D 439855 CDS YP_001743924.1 170683763 6143856 1894624..1895985 1 NC_010498.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1895985 trpC 6143856 trpC Escherichia coli SMS-3-5 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_001743924.1 1894624 D 439855 CDS YP_001743925.1 170683411 6143055 1895997..1897190 1 NC_010498.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1897190 trpB 6143055 trpB Escherichia coli SMS-3-5 tryptophan synthase subunit beta YP_001743925.1 1895997 D 439855 CDS YP_001743926.1 170682783 6142697 1897190..1897996 1 NC_010498.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1897996 trpA 6142697 trpA Escherichia coli SMS-3-5 tryptophan synthase subunit alpha YP_001743926.1 1897190 D 439855 CDS YP_001743927.1 170681776 6146992 1898377..1898556 1 NC_010498.1 hypothetical protein 1898556 6146992 EcSMS35_1873 Escherichia coli SMS-3-5 hypothetical protein YP_001743927.1 1898377 D 439855 CDS YP_001743928.1 170680983 6145968 1898621..1899142 1 NC_010498.1 identified by match to protein family HMM PF05974; YciF protein 1899142 yciF 6145968 yciF Escherichia coli SMS-3-5 YciF protein YP_001743928.1 1898621 D 439855 CDS YP_001743929.1 170681561 6145164 1899415..1899693 1 NC_010498.1 identified by match to protein family HMM PF05974; hypothetical protein 1899693 6145164 EcSMS35_1875 Escherichia coli SMS-3-5 hypothetical protein YP_001743929.1 1899415 D 439855 CDS YP_001743930.1 170682349 6145746 complement(1899753..1900391) 1 NC_010498.1 receptor for colicin S4; outer membrane protein W 1900391 ompW 6145746 ompW Escherichia coli SMS-3-5 outer membrane protein W YP_001743930.1 1899753 R 439855 CDS YP_001743931.1 170684316 6146548 1900746..1901489 1 NC_010498.1 identified by match to protein family HMM PF06790; hypothetical protein 1901489 6146548 EcSMS35_1877 Escherichia coli SMS-3-5 hypothetical protein YP_001743931.1 1900746 D 439855 CDS YP_001743932.1 170680207 6143618 1901519..1902058 1 NC_010498.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1902058 ispZ 6143618 ispZ Escherichia coli SMS-3-5 intracellular septation protein A YP_001743932.1 1901519 D 439855 CDS YP_001743933.1 170680833 6144373 1902163..1902561 1 NC_010498.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1902561 yciA 6144373 yciA Escherichia coli SMS-3-5 acyl-CoA thioester hydrolase YP_001743933.1 1902163 D 439855 CDS YP_001743934.1 170681605 6145010 complement(1902601..1903332) 1 NC_010498.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1903332 tonB 6145010 tonB Escherichia coli SMS-3-5 transport protein TonB YP_001743934.1 1902601 R 439855 CDS YP_001743935.1 170682147 6145790 1903541..1903837 1 NC_010498.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1903837 6145790 EcSMS35_1881 Escherichia coli SMS-3-5 YciI-like protein YP_001743935.1 1903541 D 439855 CDS YP_001743936.1 170682975 6146346 1903990..1904247 1 NC_010498.1 hypothetical protein 1904247 6146346 EcSMS35_1882 Escherichia coli SMS-3-5 hypothetical protein YP_001743936.1 1903990 D 439855 CDS YP_001743937.1 170683822 6147190 1904356..1906149 1 NC_010498.1 identified by match to protein family HMM PF00884; sulfatase family protein 1906149 6147190 EcSMS35_1884 Escherichia coli SMS-3-5 sulfatase family protein YP_001743937.1 1904356 D 439855 CDS YP_001743938.1 170682453 6143116 complement(1906146..1906745) 1 NC_010498.1 ylcE; identified by Glimmer3; putative; hypothetical protein 1906745 6143116 EcSMS35_1883 Escherichia coli SMS-3-5 hypothetical protein YP_001743938.1 1906146 R 439855 CDS YP_001743939.1 170680068 6146652 complement(1906891..1907157) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1907157 6146652 EcSMS35_1885 Escherichia coli SMS-3-5 hypothetical protein YP_001743939.1 1906891 R 439855 CDS YP_001743940.1 170680737 6144232 1907391..1907738 1 NC_010498.1 identified by similarity to GB:ABG71805.1; IS3 family transposase 1907738 6144232 EcSMS35_1886 Escherichia coli SMS-3-5 IS3 family transposase YP_001743940.1 1907391 D 439855 CDS YP_001743941.1 170681071 6144912 1907782..1908192 1 NC_010498.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1908192 6144912 EcSMS35_1887 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001743941.1 1907782 D 439855 CDS YP_001743942.1 170680938 6145253 1908150..1909055 1 NC_010498.1 identified by match to protein family HMM PF00665; IS2 transposase orfB 1909055 6145253 EcSMS35_1888 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001743942.1 1908150 D 439855 CDS YP_001743943.1 170682061 6145119 1909030..1909569 1 NC_010498.1 identified by match to protein family HMM PF00665; IS911 transposase orfB 1909569 6145119 EcSMS35_1889 Escherichia coli SMS-3-5 IS911 transposase orfB YP_001743943.1 1909030 D 439855 CDS YP_001743944.1 170682593 6146258 1910255..1911463 1 NC_010498.1 identified by match to protein family HMM PF02254; match to protein family HMM PF07885; voltage-gated potassium channel 1911463 kch 6146258 kch Escherichia coli SMS-3-5 voltage-gated potassium channel YP_001743944.1 1910255 D 439855 CDS YP_001743945.1 170683378 6146798 1911834..1913294 1 NC_010498.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1913294 cls 6146798 cls Escherichia coli SMS-3-5 cardiolipin synthetase YP_001743945.1 1911834 D 439855 CDS YP_001743946.1 170683928 6142664 1913329..1913658 1 NC_010498.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1913658 6142664 EcSMS35_1892 Escherichia coli SMS-3-5 dsDNA-mimic protein YP_001743946.1 1913329 D 439855 CDS YP_001743947.1 170680026 6143224 complement(1913711..1914715) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide ABC transporter ATP-binding protein OppF 1914715 oppF 6143224 oppF Escherichia coli SMS-3-5 oligopeptide ABC transporter ATP-binding protein OppF YP_001743947.1 1913711 R 439855 CDS YP_001743948.1 170684293 6144189 complement(1914712..1915725) 1 NC_010498.1 identified by similarity to SP:P76027; match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transporter ATP-binding component 1915725 oppD 6144189 oppD Escherichia coli SMS-3-5 oligopeptide transporter ATP-binding component YP_001743948.1 1914712 R 439855 CDS YP_001743949.1 170683469 6143595 complement(1915737..1916642) 1 NC_010498.1 identified by similarity to SP:P08006; match to protein family HMM PF00528; oligopeptide ABC transporter permease OppC 1916642 oppC 6143595 oppC Escherichia coli SMS-3-5 oligopeptide ABC transporter permease OppC YP_001743949.1 1915737 R 439855 CDS YP_001743950.1 170681715 6142758 complement(1916660..1917580) 1 NC_010498.1 identified by match to protein family HMM PF00528; oligopeptide transporter permease 1917580 oppB 6142758 oppB Escherichia coli SMS-3-5 oligopeptide transporter permease YP_001743950.1 1916660 R 439855 CDS YP_001743951.1 170681304 6145903 complement(1917666..1919342) 1 NC_010498.1 identified by match to protein family HMM PF00496; oligopeptide ABC transporter periplasmic oligopeptide-binding protein 1919342 oppA 6145903 oppA Escherichia coli SMS-3-5 oligopeptide ABC transporter periplasmic oligopeptide-binding protein YP_001743951.1 1917666 R 439855 CDS YP_001743952.1 170682343 6145488 1919581..1919877 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1919877 6145488 EcSMS35_1899 Escherichia coli SMS-3-5 hypothetical protein YP_001743952.1 1919581 D 439855 CDS YP_001743953.1 170682771 6146542 complement(1919853..1920008) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1920008 6146542 EcSMS35_1898 Escherichia coli SMS-3-5 hypothetical protein YP_001743953.1 1919853 R 439855 CDS YP_001743954.1 170681952 6146980 complement(1920035..1920682) 1 NC_010498.1 identified by match to protein family HMM PF01914; match to protein family HMM TIGR00427; hypothetical protein 1920682 6146980 EcSMS35_1900 Escherichia coli SMS-3-5 hypothetical protein YP_001743954.1 1920035 R 439855 CDS YP_001743955.1 170683946 6146148 1921159..1923834 1 NC_010498.1 identified by match to protein family HMM PF00171; match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1923834 adhE 6146148 adhE Escherichia coli SMS-3-5 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_001743955.1 1921159 D 439855 CDS YP_001743956.1 170680630 6143242 complement(1924137..1924754) 1 NC_010498.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1924754 tdk 6143242 tdk Escherichia coli SMS-3-5 thymidine kinase YP_001743956.1 1924137 R 439855 CDS YP_001743957.1 170680309 6144805 1925138..1925266 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1925266 6144805 EcSMS35_1903 Escherichia coli SMS-3-5 hypothetical protein YP_001743957.1 1925138 D 439855 CDS YP_001743958.1 170681125 6144477 1925358..1925771 1 NC_010498.1 identified by match to protein family HMM PF00816; global DNA-binding transcriptional dual regulator H-NS 1925771 6144477 EcSMS35_1904 Escherichia coli SMS-3-5 global DNA-binding transcriptional dual regulator H-NS YP_001743958.1 1925358 D 439855 CDS YP_001743959.1 170681483 6145308 complement(1925916..1926824) 1 NC_010498.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1926824 galU 6145308 galU Escherichia coli SMS-3-5 UTP--glucose-1-phosphate uridylyltransferase subunit GalU YP_001743959.1 1925916 R 439855 CDS YP_001743960.1 170681852 6145668 complement(1927026..1928039) 1 NC_010498.1 identified by match to protein family HMM PF00072; response regulator of RpoS 1928039 6145668 EcSMS35_1906 Escherichia coli SMS-3-5 response regulator of RpoS YP_001743960.1 1927026 R 439855 CDS YP_001743961.1 170679923 6146046 complement(1928131..1929075) 1 NC_010498.1 identified by match to protein family HMM PF01734; hypothetical protein 1929075 6146046 EcSMS35_1907 Escherichia coli SMS-3-5 hypothetical protein YP_001743961.1 1928131 R 439855 CDS YP_001743962.1 170683220 6144085 1929128..1929607 1 NC_010498.1 identified by match to protein family HMM PF02810; hypothetical protein 1929607 6144085 EcSMS35_1908 Escherichia coli SMS-3-5 hypothetical protein YP_001743962.1 1929128 D 439855 CDS YP_001743963.1 170683587 6147441 1929657..1930499 1 NC_010498.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1930499 purU 6147441 purU Escherichia coli SMS-3-5 formyltetrahydrofolate deformylase YP_001743963.1 1929657 D 439855 CDS YP_001743964.1 170683883 6143652 complement(1931224..1931901) 1 NC_010498.1 identified by similarity to SP:P11350; match to protein family HMM PF02665; match to protein family HMM TIGR00351; respiratory nitrate reductase 1, gamma subunit 1931901 narI 6143652 narI Escherichia coli SMS-3-5 respiratory nitrate reductase 1, gamma subunit YP_001743964.1 1931224 R 439855 CDS YP_001743965.1 170682335 6143178 complement(1931901..1932611) 1 NC_010498.1 identified by similarity to SP:P0AF26; match to protein family HMM PF02613; match to protein family HMM TIGR00684; nitrate reductase molybdenum cofactor assembly chaperone 1 1932611 narJ 6143178 narJ Escherichia coli SMS-3-5 nitrate reductase molybdenum cofactor assembly chaperone 1 YP_001743965.1 1931901 R 439855 CDS YP_001743966.1 170682579 6146534 complement(1932608..1934146) 1 NC_010498.1 identified by similarity to SP:P11349; match to protein family HMM PF00037; match to protein family HMM TIGR01660; nitrate reductase 1, beta subunit 1934146 narH 6146534 narH Escherichia coli SMS-3-5 nitrate reductase 1, beta subunit YP_001743966.1 1932608 R 439855 CDS YP_001743967.1 170681018 6146784 complement(1934143..1937886) 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; nitrate reductase 1, alpha subunit 1937886 narG 6146784 narG Escherichia coli SMS-3-5 nitrate reductase 1, alpha subunit YP_001743967.1 1934143 R 439855 CDS YP_001743968.1 170682669 6145199 complement(1938280..1939671) 1 NC_010498.1 identified by similarity to SP:P10903; match to protein family HMM PF07690; match to protein family HMM TIGR00886; nitrite extrusion protein 1 1939671 narK 6145199 narK Escherichia coli SMS-3-5 nitrite extrusion protein 1 YP_001743968.1 1938280 R 439855 CDS YP_001743969.1 170681694 6146877 complement(1939766..1939984) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1939984 6146877 EcSMS35_1917 Escherichia coli SMS-3-5 hypothetical protein YP_001743969.1 1939766 R 439855 CDS YP_001743970.1 170682187 6145880 1940010..1941806 1 NC_010498.1 identified by similarity to SP:P0AFA2; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensor protein NarX 1941806 narX 6145880 narX Escherichia coli SMS-3-5 nitrate/nitrite sensor protein NarX YP_001743970.1 1940010 D 439855 CDS YP_001743971.1 170682686 6146386 1941799..1942449 1 NC_010498.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1942449 narL 6146386 narL Escherichia coli SMS-3-5 transcriptional regulator NarL YP_001743971.1 1941799 D 439855 CDS YP_001743972.1 170683203 6146894 complement(1942450..1943844) 1 NC_010498.1 ychO; hypothetical protein 1943844 6146894 EcSMS35_1920 Escherichia coli SMS-3-5 hypothetical protein YP_001743972.1 1942450 R 439855 CDS YP_001743973.1 170684178 6147424 1944029..1944382 1 NC_010498.1 identified by match to protein family HMM PF02635; dsrE family protein 1944382 6147424 EcSMS35_1921 Escherichia coli SMS-3-5 dsrE family protein YP_001743973.1 1944029 D 439855 CDS YP_001743974.1 170682112 6143479 complement(1944426..1945121) 1 NC_010498.1 identified by match to protein family HMM PF04752; chaC protein 1945121 6143479 EcSMS35_1922 Escherichia coli SMS-3-5 chaC protein YP_001743974.1 1944426 R 439855 CDS YP_001743975.1 170682769 6146310 complement(1945279..1945509) 1 NC_010498.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1945509 chaB 6146310 chaB Escherichia coli SMS-3-5 cation transport regulator YP_001743975.1 1945279 R 439855 CDS YP_001743976.1 170683139 6146978 1945779..1946879 1 NC_010498.1 identified by match to protein family HMM PF01699; match to protein family HMM TIGR00846; calcium/sodium:proton antiporter 1946879 6146978 EcSMS35_1924 Escherichia coli SMS-3-5 calcium/sodium:proton antiporter YP_001743976.1 1945779 D 439855 CDS YP_001743977.1 170683803 6147359 1947258..1947392 1 NC_010498.1 hypothetical protein 1947392 6147359 EcSMS35_1925 Escherichia coli SMS-3-5 hypothetical protein YP_001743977.1 1947258 D 439855 CDS YP_001743978.1 170680049 6143097 1947793..1947927 1 NC_010498.1 hypothetical protein 1947927 6143097 EcSMS35_1926 Escherichia coli SMS-3-5 hypothetical protein YP_001743978.1 1947793 D 439855 CDS YP_001743979.1 170684298 6144212 complement(1948076..1948930) 1 NC_010498.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1948930 kdsA 6144212 kdsA Escherichia coli SMS-3-5 2-dehydro-3-deoxyphosphooctonate aldolase YP_001743979.1 1948076 R 439855 CDS YP_001743980.1 170680182 6143600 complement(1948966..1949775) 1 NC_010498.1 putative transcriptional regulator 1949775 sirB1 6143600 sirB1 Escherichia coli SMS-3-5 putative transcriptional regulator YP_001743980.1 1948966 R 439855 CDS YP_001743981.1 170680676 6144348 complement(1949779..1950171) 1 NC_010498.1 identified by match to protein family HMM PF04247; putative transcriptional regulator 1950171 6144348 EcSMS35_1929 Escherichia coli SMS-3-5 putative transcriptional regulator YP_001743981.1 1949779 R 439855 CDS YP_001743982.1 170683182 6144851 complement(1950168..1951001) 1 NC_010498.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1951001 hemK 6144851 hemK Escherichia coli SMS-3-5 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001743982.1 1950168 R 439855 CDS YP_001743983.1 170682630 6147402 complement(1951001..1952083) 1 NC_010498.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1952083 prfA 6147402 prfA Escherichia coli SMS-3-5 peptide chain release factor 1 YP_001743983.1 1951001 R 439855 CDS YP_001743984.1 170680594 6146836 complement(1952125..1953381) 1 NC_010498.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1953381 hemA 6146836 hemA Escherichia coli SMS-3-5 glutamyl-tRNA reductase YP_001743984.1 1952125 R 439855 CDS YP_001743985.1 170680111 6144766 1953595..1954218 1 NC_010498.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1954218 lolB 6144766 lolB Escherichia coli SMS-3-5 outer membrane lipoprotein LolB YP_001743985.1 1953595 D 439855 CDS YP_001743986.1 170681054 6144276 1954218..1955069 1 NC_010498.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1955069 ipk 6144276 ipk Escherichia coli SMS-3-5 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001743986.1 1954218 D 439855 CDS YP_001743987.1 170680628 6145235 1955154..1956167 1 NC_010498.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1956167 prs 6145235 prs Escherichia coli SMS-3-5 ribose-phosphate pyrophosphokinase YP_001743987.1 1955154 D 439855 CDS YP_001743988.1 170679649 6144803 1956292..1957971 1 NC_010498.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM 1957971 ychM 6144803 ychM Escherichia coli SMS-3-5 putative sulfate transporter YchM YP_001743988.1 1956292 D 439855 CDS YP_001743989.1 170683871 6143806 complement(1958026..1958304) 1 NC_010498.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1958304 6143806 EcSMS35_1937 Escherichia coli SMS-3-5 hypothetical protein YP_001743989.1 1958026 R 439855 CDS YP_001743990.1 170681473 6143166 1958582..1959166 1 NC_010498.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1959166 pth 6143166 pth Escherichia coli SMS-3-5 peptidyl-tRNA hydrolase YP_001743990.1 1958582 D 439855 CDS YP_001743991.1 170680985 6145658 1959283..1960374 1 NC_010498.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1960374 engD 6145658 engD Escherichia coli SMS-3-5 GTP-dependent nucleic acid-binding protein EngD YP_001743991.1 1959283 D 439855 CDS YP_001743992.1 170682289 6145166 complement(1960779..1962698) 1 NC_010498.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1962698 dhaR 6145166 dhaR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator DhaR YP_001743992.1 1960779 R 439855 CDS YP_001743993.1 170681763 6146488 1962926..1963996 1 NC_010498.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1963996 dhaK 6146488 dhaK Escherichia coli SMS-3-5 dihydroxyacetone kinase subunit DhaK YP_001743993.1 1962926 D 439855 CDS YP_001743994.1 170682562 6145954 1964007..1964639 1 NC_010498.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1964639 dhaL 6145954 dhaL Escherichia coli SMS-3-5 dihydroxyacetone kinase subunit DhaL YP_001743994.1 1964007 D 439855 CDS YP_001743995.1 170682048 6146765 1964650..1966068 1 NC_010498.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1966068 dhaM 6146765 dhaM Escherichia coli SMS-3-5 dihydroxyacetone kinase subunit M YP_001743995.1 1964650 D 439855 CDS YP_001743996.1 170683927 6146245 1966095..1966208 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1966208 6146245 EcSMS35_1944 Escherichia coli SMS-3-5 hypothetical protein YP_001743996.1 1966095 D 439855 CDS YP_001743997.1 170683395 6143223 complement(1966227..1966400) 1 NC_010498.1 hypothetical protein 1966400 6143223 EcSMS35_1945 Escherichia coli SMS-3-5 hypothetical protein YP_001743997.1 1966227 R 439855 CDS YP_001743998.1 170681871 6142681 1966387..1968084 1 NC_010498.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1968084 treA 6142681 treA Escherichia coli SMS-3-5 trehalase YP_001743998.1 1966387 D 439855 CDS YP_001743999.1 170681965 6146065 1968414..1969436 1 NC_010498.1 identified by match to protein family HMM PF01497; iron(III) ABC transporter periplasmic iron(III)-binding protein 1969436 6146065 EcSMS35_1947 Escherichia coli SMS-3-5 iron(III) ABC transporter periplasmic iron(III)-binding protein YP_001743999.1 1968414 D 439855 CDS YP_001744000.1 170680346 6146161 1969436..1970416 1 NC_010498.1 identified by match to protein family HMM PF00950; match to protein family HMM PF01032; iron(III) ABC transporter permease 1970416 6146161 EcSMS35_1948 Escherichia coli SMS-3-5 iron(III) ABC transporter permease YP_001744000.1 1969436 D 439855 CDS YP_001744001.1 170681000 6144514 1970413..1971171 1 NC_010498.1 identified by match to protein family HMM PF00005; iron(III) ABC transporter ATP-binding protein 1971171 6144514 EcSMS35_1949 Escherichia coli SMS-3-5 iron(III) ABC transporter ATP-binding protein YP_001744001.1 1970413 D 439855 CDS YP_001744002.1 170679815 6145181 1971181..1971993 1 NC_010498.1 identified by match to protein family HMM PF08242; putative methyltransferase 1971993 6145181 EcSMS35_1950 Escherichia coli SMS-3-5 putative methyltransferase YP_001744002.1 1971181 D 439855 CDS YP_001744003.1 170679887 6143976 1971990..1972844 1 NC_010498.1 involved in molybdenum transport; molybdenum transport protein ModD 1972844 modD 6143976 modD Escherichia coli SMS-3-5 molybdenum transport protein ModD YP_001744003.1 1971990 D 439855 CDS YP_001744004.1 170682916 6144049 1972870..1974840 1 NC_010498.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1974840 6144049 EcSMS35_1952 Escherichia coli SMS-3-5 TonB-dependent receptor YP_001744004.1 1972870 D 439855 CDS YP_001744005.1 170683593 6147130 complement(1974890..1975144) 1 NC_010498.1 identified by match to protein family HMM PF04226; transglycosylase-associated protein 1975144 6147130 EcSMS35_1953 Escherichia coli SMS-3-5 transglycosylase-associated protein YP_001744005.1 1974890 R 439855 CDS YP_001744006.1 170682400 6142884 1975345..1976079 1 NC_010498.1 identified by match to protein family HMM PF07238; match to protein family HMM PF07317; putative type IV pilus assembly protein PilZ 1976079 6142884 EcSMS35_1954 Escherichia coli SMS-3-5 putative type IV pilus assembly protein PilZ YP_001744006.1 1975345 D 439855 CDS YP_001744007.1 170683062 6146599 complement(1976081..1976692) 1 NC_010498.1 identified by match to protein family HMM PF01464; membrane-bound lytic murein transglycosylase E 1976692 mltE 6146599 mltE Escherichia coli SMS-3-5 membrane-bound lytic murein transglycosylase E YP_001744007.1 1976081 R 439855 CDS YP_001744008.1 170683906 6147279 1976792..1977706 1 NC_010498.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1977706 ldcA 6147279 ldcA Escherichia coli SMS-3-5 L,D-carboxypeptidase A YP_001744008.1 1976792 D 439855 CDS YP_001744009.1 170683359 6143202 1977801..1979537 1 NC_010498.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1979537 cvrA 6143202 cvrA Escherichia coli SMS-3-5 potassium/proton antiporter YP_001744009.1 1977801 D 439855 CDS YP_001744010.1 170682033 6142645 1980286..1981593 1 NC_010498.1 identified by similarity to GB:ABB61379.1; hypothetical protein 1981593 6142645 EcSMS35_1958 Escherichia coli SMS-3-5 hypothetical protein YP_001744010.1 1980286 D 439855 CDS YP_001744011.1 170681793 6146230 complement(1981763..1982833) 1 NC_010498.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1982833 dadX 6146230 dadX Escherichia coli SMS-3-5 alanine racemase YP_001744011.1 1981763 R 439855 CDS YP_001744012.1 170681298 6145986 complement(1982843..1984147) 1 NC_010498.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1984147 dadA 6145986 dadA Escherichia coli SMS-3-5 D-amino acid dehydrogenase small subunit YP_001744012.1 1982843 R 439855 CDS YP_001744013.1 170681824 6145482 1984471..1986003 1 NC_010498.1 identified by match to protein family HMM PF04293; SpoVR family protein 1986003 6145482 EcSMS35_1961 Escherichia coli SMS-3-5 SpoVR family protein YP_001744013.1 1984471 D 439855 CDS YP_001744014.1 170681324 6146017 complement(1986055..1986774) 1 NC_010498.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1986774 fadR 6146017 fadR Escherichia coli SMS-3-5 fatty acid metabolism regulator YP_001744014.1 1986055 R 439855 CDS YP_001744015.1 170680470 6145508 1986997..1988538 1 NC_010498.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1988538 nhaB 6145508 nhaB Escherichia coli SMS-3-5 sodium/proton antiporter YP_001744015.1 1986997 D 439855 CDS YP_001744016.1 170679961 6144639 1988684..1989214 1 NC_010498.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1989214 dsbB 6144639 dsbB Escherichia coli SMS-3-5 disulfide bond formation protein B YP_001744016.1 1988684 D 439855 CDS YP_001744017.1 170683122 6144123 complement(1989260..1990528) 1 NC_010498.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1990528 umuC 6144123 umuC Escherichia coli SMS-3-5 DNA polymerase V subunit UmuC YP_001744017.1 1989260 R 439855 CDS YP_001744018.1 170683779 6147341 complement(1990528..1990947) 1 NC_010498.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1990947 umuD 6147341 umuD Escherichia coli SMS-3-5 DNA polymerase V subunit UmuD YP_001744018.1 1990528 R 439855 CDS YP_001744019.1 170682110 6143071 1991319..1992230 1 NC_010498.1 Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E 1992230 hlyE 6143071 hlyE Escherichia coli SMS-3-5 hemolysin E YP_001744019.1 1991319 D 439855 CDS YP_001744020.1 170682813 6146308 complement(1992437..1992898) 1 NC_010498.1 identified by match to protein family HMM PF03692; hypothetical protein 1992898 6146308 EcSMS35_1968 Escherichia coli SMS-3-5 hypothetical protein YP_001744020.1 1992437 R 439855 CDS YP_001744021.1 170683058 6147024 complement(1992975..1993634) 1 NC_010498.1 identified by match to protein family HMM PF01557; hypothetical protein 1993634 6147024 EcSMS35_1969 Escherichia coli SMS-3-5 hypothetical protein YP_001744021.1 1992975 R 439855 CDS YP_001744022.1 170681057 6147275 complement(1993706..1993999) 1 NC_010498.1 identified by match to protein family HMM PF05166; hypothetical protein 1993999 6147275 EcSMS35_1970 Escherichia coli SMS-3-5 hypothetical protein YP_001744022.1 1993706 R 439855 CDS YP_001744023.1 170680809 6145238 1994242..1994643 1 NC_010498.1 identified by match to protein family HMM PF04151; pre-peptidase C-terminal domain-containing protein 1994643 6145238 EcSMS35_1971 Escherichia coli SMS-3-5 pre-peptidase C-terminal domain-containing protein YP_001744023.1 1994242 D 439855 CDS YP_001744024.1 170681452 6144985 complement(1994746..1995114) 1 NC_010498.1 identified by match to protein family HMM PF05666; putative fels-1 prophage protein 1995114 6144985 EcSMS35_1972 Escherichia coli SMS-3-5 putative fels-1 prophage protein YP_001744024.1 1994746 R 439855 CDS YP_001744025.1 170680388 6145637 1995634..1996329 1 NC_010498.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1996329 minC 6145637 minC Escherichia coli SMS-3-5 septum formation inhibitor YP_001744025.1 1995634 D 439855 CDS YP_001744026.1 170683168 6144557 1996353..1997165 1 NC_010498.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1997165 minD 6144557 minD Escherichia coli SMS-3-5 cell division inhibitor MinD YP_001744026.1 1996353 D 439855 CDS YP_001744027.1 170682909 6147388 1997169..1997435 1 NC_010498.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1997435 minE 6147388 minE Escherichia coli SMS-3-5 cell division topological specificity factor MinE YP_001744027.1 1997169 D 439855 CDS YP_001744028.1 170681171 6147123 complement(1997802..1998128) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1998128 6147123 EcSMS35_1976 Escherichia coli SMS-3-5 hypothetical protein YP_001744028.1 1997802 R 439855 CDS YP_001744029.1 170681869 6145355 1998546..1998719 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1998719 6145355 EcSMS35_1977 Escherichia coli SMS-3-5 hypothetical protein YP_001744029.1 1998546 D 439855 CDS YP_001744030.1 170679579 6146063 1998721..1999065 1 NC_010498.1 hypothetical protein 1999065 6146063 EcSMS35_1978 Escherichia coli SMS-3-5 hypothetical protein YP_001744030.1 1998721 D 439855 CDS YP_001744031.1 170680228 6143736 1999075..1999404 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 1999404 6143736 EcSMS35_1979 Escherichia coli SMS-3-5 hypothetical protein YP_001744031.1 1999075 D 439855 CDS YP_001744032.1 170683308 6144394 complement(1999462..2001783) 1 NC_010498.1 identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; autotransporter (AT) family porin 2001783 6144394 EcSMS35_1980 Escherichia coli SMS-3-5 autotransporter (AT) family porin YP_001744032.1 1999462 R 439855 CDS YP_001744033.1 170682389 6147534 complement(2002274..2002393) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2002393 6147534 EcSMS35_1981 Escherichia coli SMS-3-5 hypothetical protein YP_001744033.1 2002274 R 439855 CDS YP_001744034.1 170684081 6146588 complement(2002510..2002728) 1 NC_010498.1 hypothetical protein 2002728 6146588 EcSMS35_1982 Escherichia coli SMS-3-5 hypothetical protein YP_001744034.1 2002510 R 439855 CDS YP_001744035.1 170683384 6143381 complement(2002860..2004320) 1 NC_010498.1 identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 2004320 6143381 EcSMS35_1983 Escherichia coli SMS-3-5 cyclic diguanylate phosphodiesterase domain-containing protein YP_001744035.1 2002860 R 439855 CDS YP_001744036.1 170680345 6142670 complement(2004715..2004891) 1 NC_010498.1 hypothetical protein 2004891 6142670 EcSMS35_1984 Escherichia coli SMS-3-5 hypothetical protein YP_001744036.1 2004715 R 439855 CDS YP_001744037.1 170683970 6144513 complement(2005076..2005342) 1 NC_010498.1 hypothetical protein 2005342 6144513 EcSMS35_1985 Escherichia coli SMS-3-5 hypothetical protein YP_001744037.1 2005076 R 439855 CDS YP_001744038.1 170680510 6143267 2006236..2007447 1 NC_010498.1 identified by match to protein family HMM PF00563; match to protein family HMM PF04940; BLUF/cyclic diguanylate phosphodiesterase domain-containing protein 2007447 6143267 EcSMS35_1986 Escherichia coli SMS-3-5 BLUF/cyclic diguanylate phosphodiesterase domain-containing protein YP_001744038.1 2006236 D 439855 CDS YP_001744039.1 170679977 6144680 2007652..2008383 1 NC_010498.1 identified by match to protein family HMM PF00376; transcriptional regulator mlrA 2008383 mlrA 6144680 mlrA Escherichia coli SMS-3-5 transcriptional regulator mlrA YP_001744039.1 2007652 D 439855 CDS YP_001744040.1 170681837 6144139 2008604..2009008 1 NC_010498.1 identified by match to protein family HMM PF07166; hypothetical protein 2009008 6144139 EcSMS35_1988 Escherichia coli SMS-3-5 hypothetical protein YP_001744040.1 2008604 D 439855 CDS YP_001744041.1 170679954 6146030 complement(2010137..2011387) 1 NC_010498.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 2011387 icd 6146030 icd Escherichia coli SMS-3-5 isocitrate dehydrogenase YP_001744041.1 2010137 R 439855 CDS YP_001744042.1 170681779 6144116 2011589..2012212 1 NC_010498.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 2012212 rluE 6144116 rluE Escherichia coli SMS-3-5 23S rRNA pseudouridine synthase E YP_001744042.1 2011589 D 439855 CDS YP_001744043.1 170681329 6145971 2012222..2012683 1 NC_010498.1 identified by match to protein family HMM PF00293; NUDIX family hydrolase 2012683 6145971 EcSMS35_1991 Escherichia coli SMS-3-5 NUDIX family hydrolase YP_001744043.1 2012222 D 439855 CDS YP_001744044.1 170682526 6145513 2012737..2013843 1 NC_010498.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2013843 mnmA 6145513 mnmA Escherichia coli SMS-3-5 tRNA-specific 2-thiouridylase MnmA YP_001744044.1 2012737 D 439855 CDS YP_001744045.1 170682053 6146727 2013879..2014520 1 NC_010498.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 2014520 6146727 EcSMS35_1993 Escherichia coli SMS-3-5 hypothetical protein YP_001744045.1 2013879 D 439855 CDS YP_001744046.1 170682479 6146250 2014524..2015894 1 NC_010498.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2015894 purB 6146250 purB Escherichia coli SMS-3-5 adenylosuccinate lyase YP_001744046.1 2014524 D 439855 CDS YP_001744047.1 170681232 6146678 2016063..2016734 1 NC_010498.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 2016734 phoP 6146678 phoP Escherichia coli SMS-3-5 DNA-binding transcriptional regulator PhoP YP_001744047.1 2016063 D 439855 CDS YP_001744048.1 170681883 6145416 2016734..2018194 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF08918; sensor protein PhoQ 2018194 phoQ 6145416 phoQ Escherichia coli SMS-3-5 sensor protein PhoQ YP_001744048.1 2016734 D 439855 CDS YP_001744049.1 170680524 6146077 2018270..2019391 1 NC_010498.1 identified by match to protein family HMM PF08007; cupin family protein 2019391 6146077 EcSMS35_1997 Escherichia coli SMS-3-5 cupin family protein YP_001744049.1 2018270 D 439855 CDS YP_001744050.1 170683561 6144694 complement(2019440..2020708) 1 NC_010498.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 2020708 pepT 6144694 pepT Escherichia coli SMS-3-5 peptidase T YP_001744050.1 2019440 R 439855 CDS YP_001744051.1 170683326 6142851 2020686..2020937 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2020937 6142851 EcSMS35_1999 Escherichia coli SMS-3-5 hypothetical protein YP_001744051.1 2020686 D 439855 CDS YP_001744052.1 170682237 6142611 2020916..2022052 1 NC_010498.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 2022052 potA 6142611 potA Escherichia coli SMS-3-5 putrescine/spermidine ABC transporter ATPase protein YP_001744052.1 2020916 D 439855 CDS YP_001744053.1 170681466 6146436 2022036..2022893 1 NC_010498.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 2022893 potB 6146436 potB Escherichia coli SMS-3-5 spermidine/putrescine ABC transporter membrane protein YP_001744053.1 2022036 D 439855 CDS YP_001744054.1 170680660 6145651 2022890..2023684 1 NC_010498.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 2023684 potC 6145651 potC Escherichia coli SMS-3-5 spermidine/putrescine ABC transporter membrane protein YP_001744054.1 2022890 D 439855 CDS YP_001744055.1 170680447 6144835 2023681..2024727 1 NC_010498.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 2024727 potD 6144835 potD Escherichia coli SMS-3-5 spermidine/putrescine ABC transporter periplasmic substrate-binding protein YP_001744055.1 2023681 D 439855 CDS YP_001744056.1 170683204 6144616 2024785..2025246 1 NC_010498.1 hypothetical protein 2025246 6144616 EcSMS35_2004 Escherichia coli SMS-3-5 hypothetical protein YP_001744056.1 2024785 D 439855 CDS YP_001744057.1 170684259 6147425 2025243..2026031 1 NC_010498.1 hypothetical protein 2026031 6147425 EcSMS35_2005 Escherichia coli SMS-3-5 hypothetical protein YP_001744057.1 2025243 D 439855 CDS YP_001744058.1 170683527 6143561 complement(2026169..2026990) 1 NC_010498.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 2026990 npdA 6143561 npdA Escherichia coli SMS-3-5 NAD-dependent deacetylase YP_001744058.1 2026169 R 439855 CDS YP_001744059.1 170682022 6142817 complement(2027006..2027917) 1 NC_010498.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 2027917 nagK 6142817 nagK Escherichia coli SMS-3-5 N-acetyl-D-glucosamine kinase YP_001744059.1 2027006 R 439855 CDS YP_001744060.1 170682380 6146219 complement(2027946..2029190) 1 NC_010498.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 2029190 lolE 6146219 lolE Escherichia coli SMS-3-5 outer membrane-specific lipoprotein transporter subunit LolE YP_001744060.1 2027946 R 439855 CDS YP_001744061.1 170679953 6146579 complement(2029190..2029891) 1 NC_010498.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 2029891 lolD 6146579 lolD Escherichia coli SMS-3-5 lipoprotein transporter ATP-binding subunit YP_001744061.1 2029190 R 439855 CDS YP_001744062.1 170683814 6144115 complement(2029884..2031083) 1 NC_010498.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 2031083 lolC 6144115 lolC Escherichia coli SMS-3-5 outer membrane-specific lipoprotein transporter subunit LolC YP_001744062.1 2029884 R 439855 CDS YP_001744063.1 170683490 6143108 2031344..2032417 1 NC_010498.1 identified by match to protein family HMM PF01757; putative acyltransferase 2032417 6143108 EcSMS35_2011 Escherichia coli SMS-3-5 putative acyltransferase YP_001744063.1 2031344 D 439855 CDS YP_001744064.1 170682845 6142779 2032545..2035991 1 NC_010498.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 2035991 mfd 6142779 mfd Escherichia coli SMS-3-5 transcription-repair coupling factor YP_001744064.1 2032545 D 439855 CDS YP_001744065.1 170681577 6147057 2036139..2037098 1 NC_010498.1 identified by match to protein family HMM PF01476; match to protein family HMM PF03734; LysM/ErfK/YbiS/YcfS/YnhG family protein 2037098 6147057 EcSMS35_2013 Escherichia coli SMS-3-5 LysM/ErfK/YbiS/YcfS/YnhG family protein YP_001744065.1 2036139 D 439855 CDS YP_001744066.1 170680925 6145762 complement(2037180..2037437) 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 2037437 6145762 EcSMS35_2014 Escherichia coli SMS-3-5 hypothetical protein YP_001744066.1 2037180 R 439855 CDS YP_001744067.1 170680989 6145106 2037678..2038310 1 NC_010498.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2038310 6145106 EcSMS35_2015 Escherichia coli SMS-3-5 TetR family transcriptional regulator YP_001744067.1 2037678 D 439855 CDS YP_001744068.1 170679604 6145170 complement(2038372..2038911) 1 NC_010498.1 identified by match to protein family HMM PF05433; hypothetical protein 2038911 6145170 EcSMS35_2016 Escherichia coli SMS-3-5 hypothetical protein YP_001744068.1 2038372 R 439855 CDS YP_001744069.1 170683647 6143761 complement(2039138..2040442) 1 NC_010498.1 identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF07992; NADH dehydrogenase 2040442 ndh 6143761 ndh Escherichia coli SMS-3-5 NADH dehydrogenase YP_001744069.1 2039138 R 439855 CDS YP_001744070.1 170684181 6142939 complement(2040842..2041384) 1 NC_010498.1 identified by match to protein family HMM PF05728; hypothetical protein 2041384 6142939 EcSMS35_2018 Escherichia coli SMS-3-5 hypothetical protein YP_001744070.1 2040842 R 439855 CDS YP_001744071.1 170683662 6143482 complement(2041407..2042432) 1 NC_010498.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 2042432 nagZ 6143482 nagZ Escherichia coli SMS-3-5 beta-hexosaminidase YP_001744071.1 2041407 R 439855 CDS YP_001744072.1 170684187 6142954 complement(2042443..2043267) 1 NC_010498.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 2043267 thiK 6142954 thiK Escherichia coli SMS-3-5 thiamine kinase YP_001744072.1 2042443 R 439855 CDS YP_001744073.1 170682321 6143488 complement(2043248..2043889) 1 NC_010498.1 identified by match to protein family HMM TIGR02722; putative lipoprotein 2043889 6143488 EcSMS35_2021 Escherichia coli SMS-3-5 putative lipoprotein YP_001744073.1 2043248 R 439855 CDS YP_001744074.1 170682863 6146520 complement(2043903..2044256) 1 NC_010498.1 identified by match to protein family HMM PF07233; putative lipoprotein 2044256 6146520 EcSMS35_2022 Escherichia coli SMS-3-5 putative lipoprotein YP_001744074.1 2043903 R 439855 CDS YP_001744075.1 170681005 6147076 complement(2044283..2044642) 1 NC_010498.1 identified by match to protein family HMM PF01230; purine nucleoside phosphoramidase 2044642 hinT 6147076 hinT Escherichia coli SMS-3-5 purine nucleoside phosphoramidase YP_001744075.1 2044283 R 439855 CDS YP_001744076.1 170681437 6145186 2044773..2044943 1 NC_010498.1 hypothetical protein 2044943 6145186 EcSMS35_2024 Escherichia coli SMS-3-5 hypothetical protein YP_001744076.1 2044773 D 439855 CDS YP_001744077.1 170682970 6145621 2044976..2047165 1 NC_010498.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; ferric-rhodotorulic acid outer membrane transporter 2047165 fhuE 6145621 fhuE Escherichia coli SMS-3-5 ferric-rhodotorulic acid outer membrane transporter YP_001744077.1 2044976 D 439855 CDS YP_001744078.1 170681251 6147185 complement(2047225..2048658) 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 2048658 ptsG 6147185 ptsG Escherichia coli SMS-3-5 PTS system glucose-specific transporter subunits IIBC YP_001744078.1 2047225 R 439855 CDS YP_001744079.1 170681009 6145435 complement(2048953..2049750) 1 NC_010498.1 identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; putative metallodependent hydrolase 2049750 6145435 EcSMS35_2027 Escherichia coli SMS-3-5 putative metallodependent hydrolase YP_001744079.1 2048953 R 439855 CDS YP_001744080.1 170681498 6145190 complement(2049761..2050765) 1 NC_010498.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 2050765 holB 6145190 holB Escherichia coli SMS-3-5 DNA polymerase III subunit delta' YP_001744080.1 2049761 R 439855 CDS YP_001744081.1 170679734 6145683 complement(2050762..2051403) 1 NC_010498.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 2051403 tmk 6145683 tmk Escherichia coli SMS-3-5 thymidylate kinase YP_001744081.1 2050762 R 439855 CDS YP_001744082.1 170680200 6143892 complement(2051393..2052415) 1 NC_010498.1 identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; hypothetical protein 2052415 6143892 EcSMS35_2030 Escherichia coli SMS-3-5 hypothetical protein YP_001744082.1 2051393 R 439855 CDS YP_001744083.1 170683633 6144366 complement(2052418..2053227) 1 NC_010498.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 2053227 pabC 6144366 pabC Escherichia coli SMS-3-5 4-amino-4-deoxychorismate lyase YP_001744083.1 2052418 R 439855 CDS YP_001744084.1 170684179 6142924 complement(2053347..2054588) 1 NC_010498.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 2054588 fabF 6142924 fabF Escherichia coli SMS-3-5 3-oxoacyl-(acyl carrier protein) synthase II YP_001744084.1 2053347 R 439855 CDS YP_001744085.1 170681281 6143480 complement(2054676..2054912) 1 NC_010498.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2054912 acpP 6143480 acpP Escherichia coli SMS-3-5 acyl carrier protein YP_001744085.1 2054676 R 439855 CDS YP_001744086.1 170681771 6145465 complement(2055123..2055857) 1 NC_010498.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 2055857 fabG 6145465 fabG Escherichia coli SMS-3-5 3-ketoacyl-(acyl-carrier-protein) reductase YP_001744086.1 2055123 R 439855 CDS YP_001744087.1 170683344 6145963 complement(2055870..2056799) 1 NC_010498.1 identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 2056799 fabD 6145963 fabD Escherichia coli SMS-3-5 malonyl CoA-acyl carrier protein transacylase YP_001744087.1 2055870 R 439855 CDS YP_001744088.1 170680158 6142630 complement(2056815..2057768) 1 NC_010498.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 2057768 fabH 6142630 fabH Escherichia coli SMS-3-5 3-oxoacyl-(acyl carrier protein) synthase III YP_001744088.1 2056815 R 439855 CDS YP_001744089.1 170679989 6144324 complement(2057836..2058906) 1 NC_010498.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 2058906 plsX 6144324 plsX Escherichia coli SMS-3-5 putative glycerol-3-phosphate acyltransferase PlsX YP_001744089.1 2057836 R 439855 CDS YP_001744090.1 170681368 6144151 complement(2058987..2059160) 1 NC_010498.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2059160 rpmF 6144151 rpmF Escherichia coli SMS-3-5 50S ribosomal protein L32 YP_001744090.1 2058987 R 439855 CDS YP_001744091.1 170683047 6145552 complement(2059212..2059733) 1 NC_010498.1 identified by match to protein family HMM PF02620; hypothetical protein 2059733 6145552 EcSMS35_2039 Escherichia coli SMS-3-5 hypothetical protein YP_001744091.1 2059212 R 439855 CDS YP_001744092.1 170682397 6147263 2059893..2060516 1 NC_010498.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2060516 maf2 6147263 maf2 Escherichia coli SMS-3-5 Maf-like protein YP_001744092.1 2059893 D 439855 CDS YP_001744093.1 170684091 6146596 complement(2060627..2061586) 1 NC_010498.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 2061586 rluC 6146596 rluC Escherichia coli SMS-3-5 23S rRNA pseudouridylate synthase C YP_001744093.1 2060627 R 439855 CDS YP_001744094.1 170683427 6143391 2062159..2065332 1 NC_010498.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 2065332 rne 6143391 rne Escherichia coli SMS-3-5 ribonuclease E YP_001744094.1 2062159 D 439855 CDS YP_001744095.1 170683916 6142714 2065466..2065759 1 NC_010498.1 identified by match to protein family HMM PF08681; hypothetical protein 2065759 6142714 EcSMS35_2043 Escherichia coli SMS-3-5 hypothetical protein YP_001744095.1 2065466 D 439855 CDS YP_001744096.1 170683407 6143212 2065756..2066250 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 2066250 6143212 EcSMS35_2044 Escherichia coli SMS-3-5 acetyltransferase YP_001744096.1 2065756 D 439855 CDS YP_001744097.1 170680479 6142693 complement(2066345..2067298) 1 NC_010498.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 2067298 flgL 6142693 flgL Escherichia coli SMS-3-5 flagellar hook-associated protein FlgL YP_001744097.1 2066345 R 439855 CDS YP_001744098.1 170683657 6144648 complement(2067310..2068953) 1 NC_010498.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 2068953 flgK 6144648 flgK Escherichia coli SMS-3-5 flagellar hook-associated protein FlgK YP_001744098.1 2067310 R 439855 CDS YP_001744099.1 170683831 6142949 complement(2069019..2069960) 1 NC_010498.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 2069960 flgJ 6142949 flgJ Escherichia coli SMS-3-5 flagellar rod assembly protein/muramidase FlgJ YP_001744099.1 2069019 R 439855 CDS YP_001744100.1 170681975 6143125 complement(2069960..2071057) 1 NC_010498.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 2071057 flgI 6143125 flgI Escherichia coli SMS-3-5 flagellar basal body P-ring protein YP_001744100.1 2069960 R 439855 CDS YP_001744101.1 170681726 6146171 complement(2071069..2071767) 1 NC_010498.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 2071767 flgH 6146171 flgH Escherichia coli SMS-3-5 flagellar basal body L-ring protein YP_001744101.1 2071069 R 439855 CDS YP_001744102.1 170679890 6145914 complement(2071820..2072602) 1 NC_010498.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 2072602 flgG 6145914 flgG Escherichia coli SMS-3-5 flagellar basal body rod protein FlgG YP_001744102.1 2071820 R 439855 CDS YP_001744103.1 170680164 6144052 complement(2072739..2073494) 1 NC_010498.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 2073494 flgF 6144052 flgF Escherichia coli SMS-3-5 flagellar basal body rod protein FlgF YP_001744103.1 2072739 R 439855 CDS YP_001744104.1 170683341 6144330 complement(2073514..2074719) 1 NC_010498.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 2074719 flgE 6144330 flgE Escherichia coli SMS-3-5 flagellar hook protein FlgE YP_001744104.1 2073514 R 439855 CDS YP_001744105.1 170682037 6142626 complement(2074744..2075439) 1 NC_010498.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 2075439 flgD 6142626 flgD Escherichia coli SMS-3-5 flagellar basal body rod modification protein YP_001744105.1 2074744 R 439855 CDS YP_001744106.1 170682563 6146234 complement(2075451..2075855) 1 NC_010498.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 2075855 flgC 6146234 flgC Escherichia coli SMS-3-5 flagellar basal body rod protein FlgC YP_001744106.1 2075451 R 439855 CDS YP_001744107.1 170683265 6146766 complement(2075859..2076275) 1 NC_010498.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 2076275 flgB 6146766 flgB Escherichia coli SMS-3-5 flagellar basal body rod protein FlgB YP_001744107.1 2075859 R 439855 CDS YP_001744108.1 170683974 6147490 complement(2076292..2076462) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2076462 6147490 EcSMS35_2056 Escherichia coli SMS-3-5 hypothetical protein YP_001744108.1 2076292 R 439855 CDS YP_001744109.1 170681963 6143271 2076431..2077090 1 NC_010498.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 2077090 flgA 6143271 flgA Escherichia coli SMS-3-5 flagellar basal body P-ring biosynthesis protein FlgA YP_001744109.1 2076431 D 439855 CDS YP_001744110.1 170682624 6146159 2077166..2077459 1 NC_010498.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 2077459 flgM 6146159 flgM Escherichia coli SMS-3-5 anti-sigma28 factor FlgM YP_001744110.1 2077166 D 439855 CDS YP_001744111.1 170683502 6146830 2077464..2077880 1 NC_010498.1 identified by match to protein family HMM PF05130; flagella synthesis protein FlgN 2077880 flgN 6146830 flgN Escherichia coli SMS-3-5 flagella synthesis protein FlgN YP_001744111.1 2077464 D 439855 CDS YP_001744112.1 170684055 6142791 complement(2077920..2079455) 1 NC_010498.1 identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695; integral membrane protein MviN 2079455 mviN 6142791 mviN Escherichia coli SMS-3-5 integral membrane protein MviN YP_001744112.1 2077920 R 439855 CDS YP_001744113.1 170682396 6143354 complement(2079565..2080488) 1 NC_010498.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase family protein 2080488 6143354 EcSMS35_2061 Escherichia coli SMS-3-5 oxidoreductase family protein YP_001744113.1 2079565 R 439855 CDS YP_001744114.1 170682009 6146595 complement(2080490..2081137) 1 NC_010498.1 identified by match to protein family HMM PF04337; hypothetical protein 2081137 6146595 EcSMS35_2062 Escherichia coli SMS-3-5 hypothetical protein YP_001744114.1 2080490 R 439855 CDS YP_001744115.1 170680882 6146206 complement(2081148..2081732) 1 NC_010498.1 identified by match to protein family HMM PF00583; ribosomal-protein-S5-alanine N-acetyltransferase 2081732 rimJ 6146206 rimJ Escherichia coli SMS-3-5 ribosomal-protein-S5-alanine N-acetyltransferase YP_001744115.1 2081148 R 439855 CDS YP_001744116.1 170681348 6145060 2081968..2083176 1 NC_010498.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 2083176 mdtH 6145060 mdtH Escherichia coli SMS-3-5 multidrug resistance protein MdtH YP_001744116.1 2081968 D 439855 CDS YP_001744117.1 170682344 6145532 2083240..2083887 1 NC_010498.1 cofactor involved in the reduction of disulfides; glutaredoxin 2 2083887 grxB 6145532 grxB Escherichia coli SMS-3-5 glutaredoxin 2 YP_001744117.1 2083240 D 439855 CDS YP_001744118.1 170682904 6146543 2084021..2084581 1 NC_010498.1 identified by match to protein family HMM PF07273; hypothetical protein 2084581 6146543 EcSMS35_2066 Escherichia coli SMS-3-5 hypothetical protein YP_001744118.1 2084021 D 439855 CDS YP_001744119.1 170680153 6147117 2084687..2085733 1 NC_010498.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 2085733 pyrC 6147117 pyrC Escherichia coli SMS-3-5 dihydroorotase YP_001744119.1 2084687 D 439855 CDS YP_001744120.1 170680988 6144319 2085807..2086052 1 NC_010498.1 identified by match to protein family HMM PF06183; DNA damage-inducible protein I 2086052 dinI 6144319 dinI Escherichia coli SMS-3-5 DNA damage-inducible protein I YP_001744120.1 2085807 D 439855 CDS YP_001744121.1 170679713 6145169 2086342..2086596 1 NC_010498.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 2086596 bssS 6145169 bssS Escherichia coli SMS-3-5 biofilm formation regulatory protein BssS YP_001744121.1 2086342 D 439855 CDS YP_001744122.1 170680185 6143871 2086711..2087829 1 NC_010498.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 2087829 solA 6143871 solA Escherichia coli SMS-3-5 N-methyltryptophan oxidase YP_001744122.1 2086711 D 439855 CDS YP_001744123.1 170683645 6144351 2087877..2087990 1 NC_010498.1 hypothetical protein 2087990 6144351 EcSMS35_2071 Escherichia coli SMS-3-5 hypothetical protein YP_001744123.1 2087877 D 439855 CDS YP_001744124.1 170684007 6142937 complement(2088115..2088261) 1 NC_010498.1 hypothetical protein 2088261 6142937 EcSMS35_2072 Escherichia coli SMS-3-5 hypothetical protein YP_001744124.1 2088115 R 439855 CDS YP_001744125.1 170679945 6143306 2088176..2088817 1 NC_010498.1 identified by match to protein family HMM PF01292; nickel-dependent hydrogenase b-type cytochrome subunit 2088817 6143306 EcSMS35_2073 Escherichia coli SMS-3-5 nickel-dependent hydrogenase b-type cytochrome subunit YP_001744125.1 2088176 D 439855 CDS YP_001744126.1 170680452 6144107 2088821..2089396 1 NC_010498.1 identified by match to protein family HMM PF04264; hypothetical protein 2089396 yceI 6144107 yceI Escherichia coli SMS-3-5 hypothetical protein YP_001744126.1 2088821 D 439855 CDS YP_001744127.1 170680794 6144621 complement(2089438..2090490) 1 NC_010498.1 identified by match to protein family HMM PF00581; hypothetical protein 2090490 6144621 EcSMS35_2075 Escherichia coli SMS-3-5 hypothetical protein YP_001744127.1 2089438 R 439855 CDS YP_001744128.1 170681218 6144969 2090715..2091635 1 NC_010498.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2091635 lpxL 6144969 lpxL Escherichia coli SMS-3-5 lipid A biosynthesis lauroyl acyltransferase YP_001744128.1 2090715 D 439855 CDS YP_001744129.1 170679802 6145402 2091807..2093033 1 NC_010498.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 2093033 mdtG 6145402 mdtG Escherichia coli SMS-3-5 drug efflux system protein MdtG YP_001744129.1 2091807 D 439855 CDS YP_001744130.1 170680181 6143962 2093116..2093490 1 NC_010498.1 hypothetical protein 2093490 msyB 6143962 msyB Escherichia coli SMS-3-5 hypothetical protein YP_001744130.1 2093116 D 439855 CDS YP_001744131.1 170683455 6144347 complement(2093491..2093718) 1 NC_010498.1 identified by match to protein family HMM PF07119; hypothetical protein 2093718 6144347 EcSMS35_2079 Escherichia coli SMS-3-5 hypothetical protein YP_001744131.1 2093491 R 439855 CDS YP_001744132.1 170684144 6142742 complement(2093891..2096404) 1 NC_010498.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 2096404 mdoH 6142742 mdoH Escherichia coli SMS-3-5 glucosyltransferase MdoH YP_001744132.1 2093891 R 439855 CDS YP_001744133.1 170682373 6143444 complement(2096427..2097980) 1 NC_010498.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 2097980 mdoG 6143444 mdoG Escherichia coli SMS-3-5 glucan biosynthesis protein G YP_001744133.1 2096427 R 439855 CDS YP_001744134.1 170682926 6146572 2098033..2098164 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2098164 6146572 EcSMS35_2082 Escherichia coli SMS-3-5 hypothetical protein YP_001744134.1 2098033 D 439855 CDS YP_001744135.1 170683681 6147140 2098168..2098311 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2098311 6147140 EcSMS35_2083 Escherichia coli SMS-3-5 hypothetical protein YP_001744135.1 2098168 D 439855 CDS YP_001744136.1 170684209 6142973 2098356..2099513 1 NC_010498.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 2099513 mdoC 6142973 mdoC Escherichia coli SMS-3-5 glucans biosynthesis protein YP_001744136.1 2098356 D 439855 CDS YP_001744137.1 170682775 6143510 complement(2099521..2100942) 1 NC_010498.1 identified by match to protein family HMM PF00614; phopholipase D 2100942 6143510 EcSMS35_2085 Escherichia coli SMS-3-5 phopholipase D YP_001744137.1 2099521 R 439855 CDS YP_001744138.1 170681971 6146984 complement(2100944..2101477) 1 NC_010498.1 identified by match to protein family HMM PF01661; hypothetical protein 2101477 6146984 EcSMS35_2086 Escherichia coli SMS-3-5 hypothetical protein YP_001744138.1 2100944 R 439855 CDS YP_001744139.1 170683875 6146167 complement(2101572..2101727) 1 NC_010498.1 hypothetical protein 2101727 6146167 EcSMS35_2087 Escherichia coli SMS-3-5 hypothetical protein YP_001744139.1 2101572 R 439855 CDS YP_001744140.1 170683039 6143170 complement(2102004..2102336) 1 NC_010498.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 2102336 csgC 6143170 csgC Escherichia coli SMS-3-5 putative autoagglutination protein YP_001744140.1 2102004 R 439855 CDS YP_001744141.1 170679882 6147255 complement(2102394..2102849) 1 NC_010498.1 identified by match to protein family HMM PF07012; cryptic curlin major subunit 2102849 csgA 6147255 csgA Escherichia coli SMS-3-5 cryptic curlin major subunit YP_001744141.1 2102394 R 439855 CDS YP_001744142.1 170684268 6144044 complement(2102890..2103372) 1 NC_010498.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 2103372 csgB 6144044 csgB Escherichia coli SMS-3-5 curlin minor subunit YP_001744142.1 2102890 R 439855 CDS YP_001744143.1 170681225 6143570 2103448..2103633 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2103633 6143570 EcSMS35_2091 Escherichia coli SMS-3-5 hypothetical protein YP_001744143.1 2103448 D 439855 CDS YP_001744144.1 170680210 6145409 complement(2103986..2104117) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2104117 6145409 EcSMS35_2092 Escherichia coli SMS-3-5 hypothetical protein YP_001744144.1 2103986 R 439855 CDS YP_001744145.1 170682157 6144376 2104178..2104750 1 NC_010498.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 2104750 csgD 6144376 csgD Escherichia coli SMS-3-5 DNA-binding transcriptional regulator CsgD YP_001744145.1 2104178 D 439855 CDS YP_001744146.1 170681334 6146356 2104755..2105144 1 NC_010498.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 2105144 csgE 6146356 csgE Escherichia coli SMS-3-5 curli assembly protein CsgE YP_001744146.1 2104755 D 439855 CDS YP_001744147.1 170680050 6145518 2105169..2105585 1 NC_010498.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 2105585 csgF 6145518 csgF Escherichia coli SMS-3-5 curli assembly protein CsgF YP_001744147.1 2105169 D 439855 CDS YP_001744148.1 170684167 6144213 2105612..2106445 1 NC_010498.1 identified by match to protein family HMM PF03783; curli production assembly/transport subunit CsgG 2106445 csgG 6144213 csgG Escherichia coli SMS-3-5 curli production assembly/transport subunit CsgG YP_001744148.1 2105612 D 439855 CDS YP_001744149.1 170680973 6143467 complement(2106509..2107030) 1 NC_010498.1 identified by match to protein family HMM PF06496; hypothetical protein 2107030 6143467 EcSMS35_2097 Escherichia coli SMS-3-5 hypothetical protein YP_001744149.1 2106509 R 439855 CDS YP_001744150.1 170680426 6145154 complement(2107102..2107656) 1 NC_010498.1 identified by match to protein family HMM PF06192; chaperone TorD 2107656 6145154 EcSMS35_2098 Escherichia coli SMS-3-5 chaperone TorD YP_001744150.1 2107102 R 439855 CDS YP_001744151.1 170682055 6144595 complement(2107680..2108417) 1 NC_010498.1 identified by match to protein family HMM PF02811; putative hydrolase 2108417 6144595 EcSMS35_2099 Escherichia coli SMS-3-5 putative hydrolase YP_001744151.1 2107680 R 439855 CDS YP_001744152.1 170682399 6146252 complement(2108472..2109410) 1 NC_010498.1 identified by match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase family protein 2109410 6146252 EcSMS35_2100 Escherichia coli SMS-3-5 D-isomer specific 2-hydroxyacid dehydrogenase family protein YP_001744152.1 2108472 R 439855 CDS YP_001744153.1 170684239 6143679 complement(2109823..2110509) 1 NC_010498.1 identified by similarity to GB:AAZ87768.1; hypothetical protein 2110509 6143679 EcSMS35_2102 Escherichia coli SMS-3-5 hypothetical protein YP_001744153.1 2109823 R 439855 CDS YP_001744154.1 170683480 6143540 complement(2111072..2112136) 1 NC_010498.1 identified by match to protein family HMM PF02562; hypothetical protein 2112136 phoH 6143540 phoH Escherichia coli SMS-3-5 hypothetical protein YP_001744154.1 2111072 R 439855 CDS YP_001744155.1 170680570 6142769 complement(2112481..2113752) 1 NC_010498.1 identified by match to protein family HMM PF04261; match to protein family HMM TIGR01409; match to protein family HMM TIGR01412; match to protein family HMM TIGR01413; Tat-translocated enzyme 2113752 6142769 EcSMS35_2104 Escherichia coli SMS-3-5 Tat-translocated enzyme YP_001744155.1 2112481 R 439855 CDS YP_001744156.1 170682015 6144740 complement(2113758..2114885) 1 NC_010498.1 identified by match to protein family HMM PF04302; hypothetical protein 2114885 6144740 EcSMS35_2105 Escherichia coli SMS-3-5 hypothetical protein YP_001744156.1 2113758 R 439855 CDS YP_001744157.1 170683993 6146212 complement(2114943..2115773) 1 NC_010498.1 identified by match to protein family HMM PF03239; match to protein family HMM TIGR00145; iron permease FTR1 family protein 2115773 6146212 EcSMS35_2106 Escherichia coli SMS-3-5 iron permease FTR1 family protein YP_001744157.1 2114943 R 439855 CDS YP_001744158.1 170683305 6143291 2115809..2115937 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2115937 6143291 EcSMS35_2107 Escherichia coli SMS-3-5 hypothetical protein YP_001744158.1 2115809 D 439855 CDS YP_001744159.1 170682638 6147531 complement(2115993..2117501) 1 NC_010498.1 identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121; sodium/proline symporter 2117501 putP 6147531 putP Escherichia coli SMS-3-5 sodium/proline symporter YP_001744159.1 2115993 R 439855 CDS YP_001744160.1 170681977 6146844 complement(2117491..2117628) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2117628 6146844 EcSMS35_2109 Escherichia coli SMS-3-5 hypothetical protein YP_001744160.1 2117491 R 439855 CDS YP_001744161.1 170681915 6146173 complement(2117660..2117869) 1 NC_010498.1 hypothetical protein 2117869 6146173 EcSMS35_2110 Escherichia coli SMS-3-5 hypothetical protein YP_001744161.1 2117660 R 439855 CDS YP_001744162.1 170681102 6146110 2117924..2121886 1 NC_010498.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 2121886 putA 6146110 putA Escherichia coli SMS-3-5 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_001744162.1 2117924 D 439855 CDS YP_001744163.1 170680576 6145284 complement(2121926..2122564) 1 NC_010498.1 identified by match to protein family HMM PF00440; match to protein family HMM PF08362; transcriptional regulator RutR 2122564 rutR 6145284 rutR Escherichia coli SMS-3-5 transcriptional regulator RutR YP_001744163.1 2121926 R 439855 CDS YP_001744164.1 170680078 6144746 2122852..2123943 1 NC_010498.1 identified by match to protein family HMM PF00296; putative monooxygenase rutA 2123943 6144746 EcSMS35_2113 Escherichia coli SMS-3-5 putative monooxygenase rutA YP_001744164.1 2122852 D 439855 CDS YP_001744165.1 170683118 6144242 2123940..2124635 1 NC_010498.1 identified by match to protein family HMM PF00857; putative isochorismatase family protein, rutB 2124635 6144242 EcSMS35_2114 Escherichia coli SMS-3-5 putative isochorismatase family protein, rutB YP_001744165.1 2123940 D 439855 CDS YP_001744166.1 170680387 6147337 2124647..2125033 1 NC_010498.1 identified by match to protein family HMM PF01042; rutC protein 2125033 6147337 EcSMS35_2115 Escherichia coli SMS-3-5 rutC protein YP_001744166.1 2124647 D 439855 CDS YP_001744167.1 170681429 6144556 2125041..2125853 1 NC_010498.1 identified by match to protein family HMM PF00561; putative rutD protein 2125853 6144556 EcSMS35_2116 Escherichia coli SMS-3-5 putative rutD protein YP_001744167.1 2125041 D 439855 CDS YP_001744168.1 170681978 6145613 2125850..2126440 1 NC_010498.1 identified by match to protein family HMM PF00881; hypothetical protein 2126440 6145613 EcSMS35_2117 Escherichia coli SMS-3-5 hypothetical protein YP_001744168.1 2125850 D 439855 CDS YP_001744169.1 170680483 6146174 2126451..2126945 1 NC_010498.1 identified by match to protein family HMM PF01613; putative flavin reductase rutF 2126945 6146174 EcSMS35_2118 Escherichia coli SMS-3-5 putative flavin reductase rutF YP_001744169.1 2126451 D 439855 CDS YP_001744170.1 170680995 6144652 2126966..2128294 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; putative purine permease ycdG 2128294 6144652 EcSMS35_2119 Escherichia coli SMS-3-5 putative purine permease ycdG YP_001744170.1 2126966 D 439855 CDS YP_001744171.1 170684184 6145176 2128923..2129519 1 NC_010498.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 2129519 wrbA 6145176 wrbA Escherichia coli SMS-3-5 TrpR binding protein WrbA YP_001744171.1 2128923 D 439855 CDS YP_001744172.1 170679966 6143485 2129540..2129767 1 NC_010498.1 hypothetical protein 2129767 6143485 EcSMS35_2121 Escherichia coli SMS-3-5 hypothetical protein YP_001744172.1 2129540 D 439855 CDS YP_001744173.1 170683233 6144128 complement(2129805..2131046) 1 NC_010498.1 identified by match to protein family HMM PF00328; glucose-1-phosphatase/inositol phosphatase 2131046 agp 6144128 agp Escherichia coli SMS-3-5 glucose-1-phosphatase/inositol phosphatase YP_001744173.1 2129805 R 439855 CDS YP_001744174.1 170683642 6147454 complement(2131339..2132175) 1 NC_010498.1 hypothetical protein 2132175 6147454 EcSMS35_2123 Escherichia coli SMS-3-5 hypothetical protein YP_001744174.1 2131339 R 439855 CDS YP_001744175.1 170682205 6142934 2132855..2133775 1 NC_010498.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 2133775 cbpA 6142934 cbpA Escherichia coli SMS-3-5 curved DNA-binding protein CbpA YP_001744175.1 2132855 D 439855 CDS YP_001744176.1 170682744 6146404 2133775..2134080 1 NC_010498.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 2134080 cbpM 6146404 cbpM Escherichia coli SMS-3-5 chaperone-modulator protein CbpM YP_001744176.1 2133775 D 439855 CDS YP_001744177.1 170680043 6146952 complement(2134232..2134831) 1 NC_010498.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 2134831 torD 6146952 torD Escherichia coli SMS-3-5 chaperone protein TorD YP_001744177.1 2134232 R 439855 CDS YP_001744178.1 170684290 6144206 complement(2134828..2137374) 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; match to protein family HMM TIGR02164; trimethylamine-N-oxide reductase 2137374 torA 6144206 torA Escherichia coli SMS-3-5 trimethylamine-N-oxide reductase YP_001744178.1 2134828 R 439855 CDS YP_001744179.1 170680538 6143592 complement(2137374..2138546) 1 NC_010498.1 identified by match to protein family HMM PF03264; match to protein family HMM TIGR02162; cytochrome c-type protein torC 2138546 torC 6143592 torC Escherichia coli SMS-3-5 cytochrome c-type protein torC YP_001744179.1 2137374 R 439855 CDS YP_001744180.1 170682155 6144708 2138676..2139368 1 NC_010498.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 2139368 torR 6144708 torR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator TorR YP_001744180.1 2138676 D 439855 CDS YP_001744181.1 170680014 6146354 complement(2139341..2140369) 1 NC_010498.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 2140369 torT 6146354 torT Escherichia coli SMS-3-5 TMAO reductase system periplasmic protein TorT YP_001744181.1 2139341 R 439855 CDS YP_001744182.1 170681062 6144177 2140482..2143184 1 NC_010498.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 2143184 torS 6144177 torS Escherichia coli SMS-3-5 hybrid sensory histidine kinase TorS YP_001744182.1 2140482 D 439855 CDS YP_001744183.1 170682733 6145244 2143267..2144340 1 NC_010498.1 identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein 2144340 6145244 EcSMS35_2132 Escherichia coli SMS-3-5 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein YP_001744183.1 2143267 D 439855 CDS YP_001744184.1 170682144 6146941 complement(2144389..2144562) 1 NC_010498.1 identified by match to protein family HMM PF08178; GnsA/GnsB family transcriptional regulator 2144562 6146941 EcSMS35_2133 Escherichia coli SMS-3-5 GnsA/GnsB family transcriptional regulator YP_001744184.1 2144389 R 439855 CDS YP_001744185.1 170683755 6146343 complement(2144757..2144876) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2144876 6146343 EcSMS35_2134 Escherichia coli SMS-3-5 hypothetical protein YP_001744185.1 2144757 R 439855 CDS YP_001744186.1 170683191 6143047 complement(2144956..2145168) 1 NC_010498.1 identified by match to protein family HMM PF00313; cold shock protein CspG 2145168 6143047 EcSMS35_2135 Escherichia coli SMS-3-5 cold shock protein CspG YP_001744186.1 2144956 R 439855 CDS YP_001744187.1 170684041 6147411 2145454..2145666 1 NC_010498.1 identified by match to protein family HMM PF00313; cold-shock DNA-binding domain-containing protein CspH 2145666 cspH 6147411 cspH Escherichia coli SMS-3-5 cold-shock DNA-binding domain-containing protein CspH YP_001744187.1 2145454 D 439855 CDS YP_001744188.1 170682176 6143340 complement(2145654..2146964) 1 NC_010498.1 identified by similarity to SP:P07102; match to protein family HMM PF00328; phosphoanhydride phosphorylase 2146964 appA 6143340 appA Escherichia coli SMS-3-5 phosphoanhydride phosphorylase YP_001744188.1 2145654 R 439855 CDS YP_001744189.1 170683524 6146375 complement(2147149..2148285) 1 NC_010498.1 identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203; cytochrome bd-II oxidase, subunit II 2148285 appB 6146375 appB Escherichia coli SMS-3-5 cytochrome bd-II oxidase, subunit II YP_001744189.1 2147149 R 439855 CDS YP_001744190.1 170680621 6142814 complement(2148297..2149841) 1 NC_010498.1 identified by match to protein family HMM PF01654; cytochrome bd-II oxidase, subunit I 2149841 appC 6142814 appC Escherichia coli SMS-3-5 cytochrome bd-II oxidase, subunit I YP_001744190.1 2148297 R 439855 CDS YP_001744191.1 170681914 6144796 complement(2149975..2150832) 1 NC_010498.1 identified by match to protein family HMM PF04809; hydrogenase-1 operon protein HyaF 2150832 hyaF 6144796 hyaF Escherichia coli SMS-3-5 hydrogenase-1 operon protein HyaF YP_001744191.1 2149975 R 439855 CDS YP_001744192.1 170681401 6146109 complement(2150829..2151227) 1 NC_010498.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 2151227 hyaE 6146109 hyaE Escherichia coli SMS-3-5 hydrogenase-1 operon protein HyaE YP_001744192.1 2150829 R 439855 CDS YP_001744193.1 170680751 6145585 complement(2151224..2151811) 1 NC_010498.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 2151811 hyaD 6145585 hyaD Escherichia coli SMS-3-5 hydrogenase 1 maturation protease YP_001744193.1 2151224 R 439855 CDS YP_001744194.1 170682734 6144926 complement(2151808..2152515) 1 NC_010498.1 identified by match to protein family HMM PF01292; match to protein family HMM TIGR02125; hydrogenase 1 b-type cytochrome subunit 2152515 hyaC 6144926 hyaC Escherichia coli SMS-3-5 hydrogenase 1 b-type cytochrome subunit YP_001744194.1 2151808 R 439855 CDS YP_001744195.1 170683907 6146942 complement(2152534..2154327) 1 NC_010498.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 2154327 hyaB 6146942 hyaB Escherichia coli SMS-3-5 hydrogenase 1 large subunit YP_001744195.1 2152534 R 439855 CDS YP_001744196.1 170683371 6143203 complement(2154324..2155442) 1 NC_010498.1 identified by match to protein family HMM PF01058; match to protein family HMM PF08425; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; nickel-dependent hydrogenase 1, small subunit 2155442 hyaA 6143203 hyaA Escherichia coli SMS-3-5 nickel-dependent hydrogenase 1, small subunit YP_001744196.1 2154324 R 439855 CDS YP_001744197.1 170681433 6142657 2155643..2155855 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2155855 6142657 EcSMS35_2146 Escherichia coli SMS-3-5 hypothetical protein YP_001744197.1 2155643 D 439855 CDS YP_001744198.1 170680785 6143703 2156163..2156822 1 NC_010498.1 identified by match to protein family HMM PF01027; hypothetical protein 2156822 6143703 EcSMS35_2148 Escherichia coli SMS-3-5 hypothetical protein YP_001744198.1 2156163 D 439855 CDS YP_001744199.1 170682067 6144960 2156914..2157243 1 NC_010498.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 2157243 tusE 6144960 tusE Escherichia coli SMS-3-5 sulfur transfer protein TusE YP_001744199.1 2156914 D 439855 CDS YP_001744200.1 170683766 6146264 complement(2157240..2157518) 1 NC_010498.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 2157518 6146264 EcSMS35_2149 Escherichia coli SMS-3-5 acylphosphatase YP_001744200.1 2157240 R 439855 CDS YP_001744201.1 170680438 6143058 2157613..2158803 1 NC_010498.1 identified by match to protein family HMM PF03602; hypothetical protein 2158803 6143058 EcSMS35_2151 Escherichia coli SMS-3-5 hypothetical protein YP_001744201.1 2157613 D 439855 CDS YP_001744202.1 170679789 6144607 2158861..2159178 1 NC_010498.1 identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097; heat shock protein HspQ 2159178 6144607 EcSMS35_2152 Escherichia coli SMS-3-5 heat shock protein HspQ YP_001744202.1 2158861 D 439855 CDS YP_001744203.1 170681410 6143949 complement(2159223..2159636) 1 NC_010498.1 identified by match to protein family HMM PF02629; putative CoA-binding protein 2159636 6143949 EcSMS35_2153 Escherichia coli SMS-3-5 putative CoA-binding protein YP_001744203.1 2159223 R 439855 CDS YP_001744204.1 170680754 6145594 2159599..2159769 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2159769 6145594 EcSMS35_2154 Escherichia coli SMS-3-5 hypothetical protein YP_001744204.1 2159599 D 439855 CDS YP_001744205.1 170683084 6144929 2159809..2160471 1 NC_010498.1 hypothetical protein 2160471 6144929 EcSMS35_2155 Escherichia coli SMS-3-5 hypothetical protein YP_001744205.1 2159809 D 439855 CDS YP_001744206.1 170682419 6147301 2160568..2161026 1 NC_010498.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 2161026 mgsA 6147301 mgsA Escherichia coli SMS-3-5 methylglyoxal synthase YP_001744206.1 2160568 D 439855 CDS YP_001744207.1 170681833 6146618 complement(2161058..2163112) 1 NC_010498.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 2163112 helD 6146618 helD Escherichia coli SMS-3-5 DNA helicase IV YP_001744207.1 2161058 R 439855 CDS YP_001744208.1 170681332 6146026 2163235..2163681 1 NC_010498.1 identified by match to protein family HMM PF03733; hypothetical protein 2163681 6146026 EcSMS35_2158 Escherichia coli SMS-3-5 hypothetical protein YP_001744208.1 2163235 D 439855 CDS YP_001744209.1 170679898 6145516 2163691..2165853 1 NC_010498.1 identified by match to protein family HMM PF05976; match to protein family HMM TIGR01666; match to protein family HMM TIGR01667; hypothetical protein 2165853 6145516 EcSMS35_2160 Escherichia coli SMS-3-5 hypothetical protein YP_001744209.1 2163691 D 439855 CDS YP_001744210.1 170680490 6144060 complement(2165816..2166445) 1 NC_010498.1 identified by match to protein family HMM PF04993; match to protein family HMM PF04994; TfoX family protein 2166445 6144060 EcSMS35_2159 Escherichia coli SMS-3-5 TfoX family protein YP_001744210.1 2165816 R 439855 CDS YP_001744211.1 170683735 6144659 2166664..2167173 1 NC_010498.1 identified by match to protein family HMM PF03846; match to protein family HMM TIGR00623; SOS cell division inhibitor 2167173 sulA 6144659 sulA Escherichia coli SMS-3-5 SOS cell division inhibitor YP_001744211.1 2166664 D 439855 CDS YP_001744212.1 170682049 6143027 complement(2167157..2167327) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2167327 6143027 EcSMS35_2161 Escherichia coli SMS-3-5 hypothetical protein YP_001744212.1 2167157 R 439855 CDS YP_001744213.1 170681860 6146246 2167505..2168581 1 NC_010498.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 2168581 ompA 6146246 ompA Escherichia coli SMS-3-5 outer membrane protein A YP_001744213.1 2167505 D 439855 CDS YP_001744214.1 170681213 6146054 complement(2168657..2169109) 1 NC_010498.1 identified by match to protein family HMM PF06303; hypothetical protein 2169109 6146054 EcSMS35_2164 Escherichia coli SMS-3-5 hypothetical protein YP_001744214.1 2168657 R 439855 CDS YP_001744215.1 170679870 6145397 2169295..2171055 1 NC_010498.1 S16 family peptidase 2171055 6145397 EcSMS35_2165 Escherichia coli SMS-3-5 S16 family peptidase YP_001744215.1 2169295 D 439855 CDS YP_001744216.1 170681567 6144032 2171124..2171642 1 NC_010498.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 2171642 fabA 6144032 fabA Escherichia coli SMS-3-5 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_001744216.1 2171124 D 439855 CDS YP_001744217.1 170682434 6145752 complement(2172135..2172698) 1 NC_010498.1 identified by match to protein family HMM PF03886; putative lipoprotein 2172698 6145752 EcSMS35_2167 Escherichia coli SMS-3-5 putative lipoprotein YP_001744217.1 2172135 R 439855 CDS YP_001744218.1 170683101 6146633 complement(2172695..2174335) 1 NC_010498.1 identified by match to protein family HMM PF02470; paraquat-inducible protein B 2174335 pqiB 6146633 pqiB Escherichia coli SMS-3-5 paraquat-inducible protein B YP_001744218.1 2172695 R 439855 CDS YP_001744219.1 170680788 6147320 complement(2174340..2175593) 1 NC_010498.1 identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155; paraquat-inducible protein A 2175593 pqiA 6147320 pqiA Escherichia coli SMS-3-5 paraquat-inducible protein A YP_001744219.1 2174340 R 439855 CDS YP_001744220.1 170681436 6144963 complement(2175723..2177630) 1 NC_010498.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC ABC transporter ATPase 2177630 uup 6144963 uup Escherichia coli SMS-3-5 ABC ABC transporter ATPase YP_001744220.1 2175723 R 439855 CDS YP_001744221.1 170683350 6145620 complement(2177642..2179750) 1 NC_010498.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 2179750 rlmL 6145620 rlmL Escherichia coli SMS-3-5 23S rRNA m(2)G2445 methyltransferase YP_001744221.1 2177642 R 439855 CDS YP_001744222.1 170682018 6142636 2179848..2180957 1 NC_010498.1 identified by match to protein family HMM PF00111; match to protein family HMM PF03473; match to protein family HMM PF03476; MOSC domain-containing protein 2180957 6142636 EcSMS35_2173 Escherichia coli SMS-3-5 MOSC domain-containing protein YP_001744222.1 2179848 D 439855 CDS YP_001744223.1 170683889 6146215 complement(2180954..2181496) 1 NC_010498.1 identified by match to protein family HMM PF07126; hypothetical protein 2181496 6146215 EcSMS35_2172 Escherichia coli SMS-3-5 hypothetical protein YP_001744223.1 2180954 R 439855 CDS YP_001744224.1 170682541 6143184 complement(2181670..2182680) 1 NC_010498.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2182680 pyrD 6143184 pyrD Escherichia coli SMS-3-5 dihydroorotate dehydrogenase 2 YP_001744224.1 2181670 R 439855 CDS YP_001744225.1 170681882 6146742 complement(2182791..2183480) 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putativi pili assembly chaperone 2183480 6146742 EcSMS35_2175 Escherichia coli SMS-3-5 putativi pili assembly chaperone YP_001744225.1 2182791 R 439855 CDS YP_001744226.1 170682280 6146076 complement(2183494..2184006) 1 NC_010498.1 identified by match to protein family HMM PF00419; fimbrial protein 2184006 6146076 EcSMS35_2176 Escherichia coli SMS-3-5 fimbrial protein YP_001744226.1 2183494 R 439855 CDS YP_001744227.1 170683162 6146479 complement(2184017..2184469) 1 NC_010498.1 identified by match to protein family HMM PF00419; fimbrial protein 2184469 6146479 EcSMS35_2177 Escherichia coli SMS-3-5 fimbrial protein YP_001744227.1 2184017 R 439855 CDS YP_001744228.1 170683719 6147382 complement(2184571..2185641) 1 NC_010498.1 identified by match to protein family HMM PF00419; putative fimbrial protein 2185641 6147382 EcSMS35_2178 Escherichia coli SMS-3-5 putative fimbrial protein YP_001744228.1 2184571 R 439855 CDS YP_001744229.1 170682116 6143011 complement(2185632..2188232) 1 NC_010498.1 identified by match to protein family HMM PF00577; outer membrane usher protein fimD-like protein 2188232 6143011 EcSMS35_2179 Escherichia coli SMS-3-5 outer membrane usher protein fimD-like protein YP_001744229.1 2185632 R 439855 CDS YP_001744230.1 170682796 6146314 complement(2188257..2188931) 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; periplasmic pilus chaperone family protein 2188931 6146314 EcSMS35_2180 Escherichia coli SMS-3-5 periplasmic pilus chaperone family protein YP_001744230.1 2188257 R 439855 CDS YP_001744231.1 170679821 6147005 complement(2189039..2189578) 1 NC_010498.1 identified by match to protein family HMM PF00419; putative fimbrial protein 2189578 6147005 EcSMS35_2181 Escherichia coli SMS-3-5 putative fimbrial protein YP_001744231.1 2189039 R 439855 CDS YP_001744232.1 170680312 6143983 2189933..2190508 1 NC_010498.1 identified by match to protein family HMM PF02525; match to protein family HMM PF03358; NAD(P)H-dependent FMN reductase 2190508 6143983 EcSMS35_2182 Escherichia coli SMS-3-5 NAD(P)H-dependent FMN reductase YP_001744232.1 2189933 D 439855 CDS YP_001744233.1 170683457 6144480 2190501..2191460 1 NC_010498.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 2191460 6144480 EcSMS35_2183 Escherichia coli SMS-3-5 alkanesulfonate transporter substrate-binding subunit YP_001744233.1 2190501 D 439855 CDS YP_001744234.1 170680263 6142745 2191457..2192602 1 NC_010498.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 2192602 ssuD 6142745 ssuD Escherichia coli SMS-3-5 alkanesulfonate monooxygenase YP_001744234.1 2191457 D 439855 CDS YP_001744235.1 170683085 6144430 2192611..2193405 1 NC_010498.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit 2193405 ssuC 6144430 ssuC Escherichia coli SMS-3-5 alkanesulfonate transporter permease subunit YP_001744235.1 2192611 D 439855 CDS YP_001744236.1 170683607 6147302 2193402..2194169 1 NC_010498.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 2194169 ssuB 6147302 ssuB Escherichia coli SMS-3-5 aliphatic sulfonates transport ATP-binding subunit YP_001744236.1 2193402 D 439855 CDS YP_001744237.1 170683651 6142897 complement(2194212..2196824) 1 NC_010498.1 identified by match to protein family HMM PF01433; match to protein family HMM TIGR02414; aminopeptidase N 2196824 pepN 6142897 pepN Escherichia coli SMS-3-5 aminopeptidase N YP_001744237.1 2194212 R 439855 CDS YP_001744238.1 170684174 6142943 complement(2196860..2196982) 1 NC_010498.1 hypothetical protein 2196982 6142943 EcSMS35_2188 Escherichia coli SMS-3-5 hypothetical protein YP_001744238.1 2196860 R 439855 CDS YP_001744239.1 170682315 6143475 2197090..2198292 1 NC_010498.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2198292 pncB 6143475 pncB Escherichia coli SMS-3-5 nicotinate phosphoribosyltransferase YP_001744239.1 2197090 D 439855 CDS YP_001744240.1 170682866 6146514 2198460..2199860 1 NC_010498.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 2199860 asnC 6146514 asnC Escherichia coli SMS-3-5 asparaginyl-tRNA synthetase YP_001744240.1 2198460 D 439855 CDS YP_001744241.1 170682361 6147079 2200462..2201535 1 NC_010498.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 2201535 ompF 6147079 ompF Escherichia coli SMS-3-5 outer membrane protein F YP_001744241.1 2200462 D 439855 CDS YP_001744242.1 170682145 6146560 2201720..2202910 1 NC_010498.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 2202910 aspC 6146560 aspC Escherichia coli SMS-3-5 aromatic amino acid aminotransferase YP_001744242.1 2201720 D 439855 CDS YP_001744243.1 170680350 6146344 complement(2202960..2203607) 1 NC_010498.1 identified by match to protein family HMM PF00753; metallo-beta-lactamase family protein 2203607 6146344 EcSMS35_2193 Escherichia coli SMS-3-5 metallo-beta-lactamase family protein YP_001744243.1 2202960 R 439855 CDS YP_001744244.1 170680996 6144518 complement(2203634..2204182) 1 NC_010498.1 identified by match to protein family HMM PF05951; match to protein family HMM PF08291; match to protein family HMM TIGR01409; Tat pathway signal sequence domain-containing protein 2204182 6144518 EcSMS35_2194 Escherichia coli SMS-3-5 Tat pathway signal sequence domain-containing protein YP_001744244.1 2203634 R 439855 CDS YP_001744245.1 170683737 6145177 complement(2204363..2206210) 1 NC_010498.1 identified by match to protein family HMM PF01471; hypothetical protein 2206210 6145177 EcSMS35_2195 Escherichia coli SMS-3-5 hypothetical protein YP_001744245.1 2204363 R 439855 CDS YP_001744246.1 170679712 6143029 complement(2206471..2210931) 1 NC_010498.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 2210931 mukB 6143029 mukB Escherichia coli SMS-3-5 cell division protein MukB YP_001744246.1 2206471 R 439855 CDS YP_001744247.1 170683700 6143870 complement(2210931..2211635) 1 NC_010498.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 2211635 mukE 6143870 mukE Escherichia coli SMS-3-5 condesin subunit E YP_001744247.1 2210931 R 439855 CDS YP_001744248.1 170679667 6142992 complement(2211616..2212938) 1 NC_010498.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 2212938 mukF 6142992 mukF Escherichia coli SMS-3-5 condesin subunit F YP_001744248.1 2211616 R 439855 CDS YP_001744249.1 170683604 6143825 complement(2212935..2213720) 1 NC_010498.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 2213720 smtA 6143825 smtA Escherichia coli SMS-3-5 putative metallothionein SmtA YP_001744249.1 2212935 R 439855 CDS YP_001744250.1 170681104 6142894 2213856..2214635 1 NC_010498.1 identified by match to protein family HMM PF02698; hypothetical protein 2214635 6142894 EcSMS35_2201 Escherichia coli SMS-3-5 hypothetical protein YP_001744250.1 2213856 D 439855 CDS YP_001744251.1 170684302 6145286 complement(2214612..2215505) 1 NC_010498.1 hypothetical protein 2215505 6145286 EcSMS35_2200 Escherichia coli SMS-3-5 hypothetical protein YP_001744251.1 2214612 R 439855 CDS YP_001744252.1 170681729 6143604 complement(2215659..2216405) 1 NC_010498.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 2216405 kdsB 6143604 kdsB Escherichia coli SMS-3-5 3-deoxy-manno-octulosonate cytidylyltransferase YP_001744252.1 2215659 R 439855 CDS YP_001744253.1 170680062 6145918 complement(2216402..2216584) 1 NC_010498.1 identified by match to protein family HMM PF03966; hypothetical protein 2216584 6145918 EcSMS35_2203 Escherichia coli SMS-3-5 hypothetical protein YP_001744253.1 2216402 R 439855 CDS YP_001744254.1 170680727 6144226 complement(2216636..2217868) 1 NC_010498.1 identified by match to protein family HMM PF06224; hypothetical protein 2217868 6144226 EcSMS35_2204 Escherichia coli SMS-3-5 hypothetical protein YP_001744254.1 2216636 R 439855 CDS YP_001744255.1 170683237 6144902 complement(2217905..2218891) 1 NC_010498.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 2218891 lpxK 6144902 lpxK Escherichia coli SMS-3-5 tetraacyldisaccharide 4'-kinase YP_001744255.1 2217905 R 439855 CDS YP_001744256.1 170680104 6147458 complement(2218888..2220636) 1 NC_010498.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 2220636 msbA 6147458 msbA Escherichia coli SMS-3-5 lipid transporter ATP-binding/permease YP_001744256.1 2218888 R 439855 CDS YP_001744257.1 170683776 6144268 complement(2220673..2222937) 1 NC_010498.1 ycaI; identified by match to protein family HMM PF00753; match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; hypothetical protein 2222937 6144268 EcSMS35_2207 Escherichia coli SMS-3-5 hypothetical protein YP_001744257.1 2220673 R 439855 CDS YP_001744258.1 170683232 6143068 complement(2223143..2223427) 1 NC_010498.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 2223427 ihfB 6143068 ihfB Escherichia coli SMS-3-5 integration host factor subunit beta YP_001744258.1 2223143 R 439855 CDS YP_001744259.1 170682691 6147453 complement(2223587..2225260) 1 NC_010498.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 2225260 rpsA 6147453 rpsA Escherichia coli SMS-3-5 30S ribosomal protein S1 YP_001744259.1 2223587 R 439855 CDS YP_001744260.1 170682193 6146899 complement(2225371..2226054) 1 NC_010498.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 2226054 cmk 6146899 cmk Escherichia coli SMS-3-5 cytidylate kinase YP_001744260.1 2225371 R 439855 CDS YP_001744261.1 170680466 6146392 complement(2226227..2226991) 1 NC_010498.1 identified by match to protein family HMM PF01435; M48B family peptidase 2226991 6146392 EcSMS35_2211 Escherichia coli SMS-3-5 M48B family peptidase YP_001744261.1 2226227 R 439855 CDS YP_001744262.1 170679985 6144635 complement(2227127..2228455) 1 NC_010498.1 identified by match to protein family HMM PF01609; IS4 transposase 2228455 6144635 EcSMS35_2212 Escherichia coli SMS-3-5 IS4 transposase YP_001744262.1 2227127 R 439855 CDS YP_001744263.1 170683917 6144147 complement(2228599..2229882) 1 NC_010498.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 2229882 aroA 6144147 aroA Escherichia coli SMS-3-5 3-phosphoshikimate 1-carboxyvinyltransferase YP_001744263.1 2228599 R 439855 CDS YP_001744264.1 170683386 6143213 complement(2229953..2231041) 1 NC_010498.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 2231041 serC 6143213 serC Escherichia coli SMS-3-5 phosphoserine aminotransferase YP_001744264.1 2229953 R 439855 CDS YP_001744265.1 170682197 6142672 complement(2231240..2231932) 1 NC_010498.1 identified by match to protein family HMM PF04239; hypothetical protein 2231932 6142672 EcSMS35_2215 Escherichia coli SMS-3-5 hypothetical protein YP_001744265.1 2231240 R 439855 CDS YP_001744266.1 170683951 6146396 2232062..2233822 1 NC_010498.1 identified by match to protein family HMM PF02624; match to protein family HMM TIGR00702; hypothetical protein 2233822 6146396 EcSMS35_2216 Escherichia coli SMS-3-5 hypothetical protein YP_001744266.1 2232062 D 439855 CDS YP_001744267.1 170680084 6143248 2234228..2235085 1 NC_010498.1 identified by match to protein family HMM PF01226; match to protein family HMM TIGR00790; formate transporter 2235085 6143248 EcSMS35_2217 Escherichia coli SMS-3-5 formate transporter YP_001744267.1 2234228 D 439855 CDS YP_001744268.1 170681780 6144248 2235140..2237422 1 NC_010498.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 2237422 pflB2 6144248 pflB2 Escherichia coli SMS-3-5 formate acetyltransferase YP_001744268.1 2235140 D 439855 CDS YP_001744269.1 170681252 6145972 2237614..2238354 1 NC_010498.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 2238354 pflA 6145972 pflA Escherichia coli SMS-3-5 pyruvate formate lyase-activating enzyme 1 YP_001744269.1 2237614 D 439855 CDS YP_001744270.1 170680872 6145436 complement(2238564..2239994) 1 NC_010498.1 identified by match to protein family HMM PF00324; amino acid permease family protein 2239994 6145436 EcSMS35_2220 Escherichia coli SMS-3-5 amino acid permease family protein YP_001744270.1 2238564 R 439855 CDS YP_001744271.1 170682710 6145050 complement(2240204..2241352) 1 NC_010498.1 identified by match to protein family HMM PF07690; putative MFS family transporter protein 2241352 6145050 EcSMS35_2221 Escherichia coli SMS-3-5 putative MFS family transporter protein YP_001744271.1 2240204 R 439855 CDS YP_001744272.1 170682202 6146918 2241383..2241511 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2241511 6146918 EcSMS35_2222 Escherichia coli SMS-3-5 hypothetical protein YP_001744272.1 2241383 D 439855 CDS YP_001744273.1 170684157 6146401 2241667..2242293 1 NC_010498.1 ycaC; identified by match to protein family HMM PF00857; isochorismatase family protein 2242293 6146401 EcSMS35_2223 Escherichia coli SMS-3-5 isochorismatase family protein YP_001744273.1 2241667 D 439855 CDS YP_001744274.1 170683650 6143457 complement(2242329..2243192) 1 NC_010498.1 identified by match to protein family HMM PF04976; anaerobic dimethyl sulfoxide reductase, C subunit 2243192 dmsC1 6143457 dmsC1 Escherichia coli SMS-3-5 anaerobic dimethyl sulfoxide reductase, C subunit YP_001744274.1 2242329 R 439855 CDS YP_001744275.1 170680702 6142942 complement(2243194..2243811) 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951; dimethylsulfoxide reductase, B subunit 2243811 dmsB_2 6142942 dmsB_2 Escherichia coli SMS-3-5 dimethylsulfoxide reductase, B subunit YP_001744275.1 2243194 R 439855 CDS YP_001744276.1 170680161 6144877 complement(2243822..2246266) 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit 2246266 dmsA 6144877 dmsA Escherichia coli SMS-3-5 anaerobic dimethyl sulfoxide reductase, A subunit YP_001744276.1 2243822 R 439855 CDS YP_001744277.1 170683015 6144327 complement(2246505..2247797) 1 NC_010498.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 2247797 serS 6144327 serS Escherichia coli SMS-3-5 seryl-tRNA synthetase YP_001744277.1 2246505 R 439855 CDS YP_001744278.1 170682500 6147231 complement(2247888..2249231) 1 NC_010498.1 identified by match to protein family HMM PF00004; recombination factor protein RarA 2249231 6147231 EcSMS35_2228 Escherichia coli SMS-3-5 recombination factor protein RarA YP_001744278.1 2247888 R 439855 CDS YP_001744279.1 170684020 6146700 complement(2249242..2249853) 1 NC_010498.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 2249853 lolA 6146700 lolA Escherichia coli SMS-3-5 outer-membrane lipoprotein carrier protein YP_001744279.1 2249242 R 439855 CDS YP_001744280.1 170683476 6143319 complement(2250012..2254121) 1 NC_010498.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 2254121 ftsK 6143319 ftsK Escherichia coli SMS-3-5 DNA translocase FtsK YP_001744280.1 2250012 R 439855 CDS YP_001744281.1 170679860 6142765 complement(2254256..2254750) 1 NC_010498.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 2254750 lrp 6142765 lrp Escherichia coli SMS-3-5 leucine-responsive transcriptional regulator YP_001744281.1 2254256 R 439855 CDS YP_001744282.1 170681503 6144022 complement(2255113..2255226) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2255226 6144022 EcSMS35_2232 Escherichia coli SMS-3-5 hypothetical protein YP_001744282.1 2255113 R 439855 CDS YP_001744283.1 170680886 6145688 2255295..2256260 1 NC_010498.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 2256260 trxB 6145688 trxB Escherichia coli SMS-3-5 thioredoxin reductase YP_001744283.1 2255295 D 439855 CDS YP_001744284.1 170682589 6145064 2256383..2258149 1 NC_010498.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 2258149 cydD 6145064 cydD Escherichia coli SMS-3-5 cysteine/glutathione ABC transporter membrane/ATP-binding component YP_001744284.1 2256383 D 439855 CDS YP_001744285.1 170682378 6146794 2258150..2259871 1 NC_010498.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 2259871 cudC 6146794 cudC Escherichia coli SMS-3-5 cysteine/glutathione ABC transporter membrane/ATP-binding component YP_001744285.1 2258150 D 439855 CDS YP_001744286.1 170684216 6146577 2259913..2260617 1 NC_010498.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 2260617 aat 6146577 aat Escherichia coli SMS-3-5 leucyl/phenylalanyl-tRNA--protein transferase YP_001744286.1 2259913 D 439855 CDS YP_001744287.1 170681224 6143517 2260902..2261120 1 NC_010498.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2261120 infA 6143517 infA Escherichia coli SMS-3-5 translation initiation factor IF-1 YP_001744287.1 2260902 D 439855 CDS YP_001744288.1 170681767 6143643 complement(2261611..2262453) 1 NC_010498.1 hypothetical protein 2262453 6143643 EcSMS35_2239 Escherichia coli SMS-3-5 hypothetical protein YP_001744288.1 2261611 R 439855 CDS YP_001744289.1 170679924 6145959 complement(2262538..2262735) 1 NC_010498.1 identified by match to protein family HMM PF06117; hypothetical protein 2262735 6145959 EcSMS35_2240 Escherichia coli SMS-3-5 hypothetical protein YP_001744289.1 2262538 R 439855 CDS YP_001744290.1 170680332 6144086 complement(2262752..2263240) 1 NC_010498.1 hypothetical protein 2263240 6144086 EcSMS35_2241 Escherichia coli SMS-3-5 hypothetical protein YP_001744290.1 2262752 R 439855 CDS YP_001744291.1 170680461 6144500 complement(2263237..2263620) 1 NC_010498.1 identified by match to protein family HMM PF06755; hypothetical protein 2263620 6144500 EcSMS35_2242 Escherichia coli SMS-3-5 hypothetical protein YP_001744291.1 2263237 R 439855 CDS YP_001744292.1 170683765 6144630 complement(2263697..2264185) 1 NC_010498.1 identified by match to protein family HMM PF06154; YagB/YeeU/YfjZ family protein 2264185 6144630 EcSMS35_2243 Escherichia coli SMS-3-5 YagB/YeeU/YfjZ family protein YP_001744292.1 2263697 R 439855 CDS YP_001744293.1 170682073 6143057 complement(2264088..2264771) 1 NC_010498.1 hypothetical protein 2264771 6143057 EcSMS35_2244 Escherichia coli SMS-3-5 hypothetical protein YP_001744293.1 2264088 R 439855 CDS YP_001744294.1 170682030 6146270 complement(2264790..2265011) 1 NC_010498.1 identified by match to protein family HMM PF06174; hypothetical protein 2265011 6146270 EcSMS35_2245 Escherichia coli SMS-3-5 hypothetical protein YP_001744294.1 2264790 R 439855 CDS YP_001744295.1 170682543 6146227 complement(2265074..2265550) 1 NC_010498.1 identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 2265550 6146227 EcSMS35_2246 Escherichia coli SMS-3-5 RadC family DNA repair protein YP_001744295.1 2265074 R 439855 CDS YP_001744296.1 170681272 6146744 complement(2265566..2266051) 1 NC_010498.1 identified by match to protein family HMM PF03230; antirestriction protein 2266051 6146744 EcSMS35_2247 Escherichia coli SMS-3-5 antirestriction protein YP_001744296.1 2265566 R 439855 CDS YP_001744297.1 170679807 6145456 complement(2266143..2266961) 1 NC_010498.1 identified by match to protein family HMM PF06067; hypothetical protein 2266961 6145456 EcSMS35_2248 Escherichia coli SMS-3-5 hypothetical protein YP_001744297.1 2266143 R 439855 CDS YP_001744298.1 170680707 6143968 complement(2267288..2270134) 1 NC_010498.1 identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; antigen 43 2270134 flu1 6143968 flu1 Escherichia coli SMS-3-5 antigen 43 YP_001744298.1 2267288 R 439855 CDS YP_001744299.1 170683526 6144882 complement(2270145..2270258) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2270258 6144882 EcSMS35_2250 Escherichia coli SMS-3-5 hypothetical protein YP_001744299.1 2270145 R 439855 CDS YP_001744300.1 170683241 6142816 complement(2270506..2271378) 1 NC_010498.1 identified by match to protein family HMM PF01926; putative GTPase 2271378 6142816 EcSMS35_2251 Escherichia coli SMS-3-5 putative GTPase YP_001744300.1 2270506 R 439855 CDS YP_001744301.1 170682082 6147463 2271642..2273213 1 NC_010498.1 identified by match to protein family HMM PF02384; match to protein family HMM TIGR00497; type I restriction-modification system, M subunit 2273213 hsdM 6147463 hsdM Escherichia coli SMS-3-5 type I restriction-modification system, M subunit YP_001744301.1 2271642 D 439855 CDS YP_001744302.1 170682442 6146279 complement(2273207..2273710) 1 NC_010498.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 2273710 6146279 EcSMS35_2252 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001744302.1 2273207 R 439855 CDS YP_001744303.1 170680370 6146641 complement(2273721..2273933) 1 NC_010498.1 IS1 transposase orfA 2273933 6146641 EcSMS35_2254 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001744303.1 2273721 R 439855 CDS YP_001744304.1 170682772 6144538 complement(2274063..2276285) 1 NC_010498.1 identified by match to protein family HMM PF00534; match to protein family HMM PF00535; glycosyl transferase, group 1/glycosyl transferase, group 2 2276285 6144538 EcSMS35_2255 Escherichia coli SMS-3-5 glycosyl transferase, group 1/glycosyl transferase, group 2 YP_001744304.1 2274063 R 439855 CDS YP_001744305.1 170681060 6146981 2276383..2277192 1 NC_010498.1 identified by similarity to GB:ABM38486.1; hypothetical protein 2277192 6146981 EcSMS35_2256 Escherichia coli SMS-3-5 hypothetical protein YP_001744305.1 2276383 D 439855 CDS YP_001744306.1 170680700 6145242 2278306..2279298 1 NC_010498.1 identified by match to protein family HMM PF01609; IS5 transposase 2279298 6145242 EcSMS35_2257 Escherichia coli SMS-3-5 IS5 transposase YP_001744306.1 2278306 D 439855 CDS YP_001744307.1 170684064 6144875 complement(2279746..2280636) 1 NC_010498.1 identified by match to protein family HMM PF00665; IS629 transposase orfB 2280636 6144875 EcSMS35_2258 Escherichia coli SMS-3-5 IS629 transposase orfB YP_001744307.1 2279746 R 439855 CDS YP_001744308.1 170682322 6143364 complement(2280633..2280959) 1 NC_010498.1 IS629 transposase orfA 2280959 6143364 EcSMS35_2259 Escherichia coli SMS-3-5 IS629 transposase orfA YP_001744308.1 2280633 R 439855 CDS YP_001744309.1 170681490 6145092 complement(2282078..2283001) 1 NC_010498.1 identified by match to protein family HMM PF01609; IS903 transposase 2283001 6145092 EcSMS35_2261 Escherichia coli SMS-3-5 IS903 transposase YP_001744309.1 2282078 R 439855 CDS YP_001744310.1 170681557 6145675 complement(2283048..2284208) 1 NC_010498.1 identified by match to protein family HMM PF00535; glycosyl transferase, group 2 2284208 6145675 EcSMS35_2262 Escherichia coli SMS-3-5 glycosyl transferase, group 2 YP_001744310.1 2283048 R 439855 CDS YP_001744311.1 170679591 6145742 complement(2284330..2285463) 1 NC_010498.1 identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein 2285463 6145742 EcSMS35_2263 Escherichia coli SMS-3-5 glycosyl transferase, group 1 family protein YP_001744311.1 2284330 R 439855 CDS YP_001744312.1 170680732 6143748 complement(2285476..2286366) 1 NC_010498.1 identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein 2286366 6143748 EcSMS35_2264 Escherichia coli SMS-3-5 glycosyl transferase, group 2 family protein YP_001744312.1 2285476 R 439855 CDS YP_001744313.1 170680099 6144907 complement(2286363..2287517) 1 NC_010498.1 identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031; UDP-galactopyranose mutase 2287517 glf 6144907 glf Escherichia coli SMS-3-5 UDP-galactopyranose mutase YP_001744313.1 2286363 R 439855 CDS YP_001744314.1 170679598 6144263 complement(2287536..2289428) 1 NC_010498.1 identified by match to protein family HMM PF01501; glycosyl transferase family protein 2289428 6144263 EcSMS35_2266 Escherichia coli SMS-3-5 glycosyl transferase family protein YP_001744314.1 2287536 R 439855 CDS YP_001744315.1 170680867 6143755 complement(2289443..2290183) 1 NC_010498.1 identified by similarity to SP:Q48479; match to protein family HMM PF00005; O-antigen export system ATP-binding protein RfbB 2290183 rfbB 6143755 rfbB Escherichia coli SMS-3-5 O-antigen export system ATP-binding protein RfbB YP_001744315.1 2289443 R 439855 CDS YP_001744316.1 170682573 6145045 complement(2290183..2290962) 1 NC_010498.1 identified by similarity to SP:Q48475; match to protein family HMM PF01061; O-antigen export system permease RfbA 2290962 6145045 EcSMS35_2268 Escherichia coli SMS-3-5 O-antigen export system permease RfbA YP_001744316.1 2290183 R 439855 CDS YP_001744317.1 170682081 6146778 2291713..2291850 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2291850 6146778 EcSMS35_2269 Escherichia coli SMS-3-5 hypothetical protein YP_001744317.1 2291713 D 439855 CDS YP_001744318.1 170684057 6146278 2292197..2292328 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2292328 6146278 EcSMS35_2270 Escherichia coli SMS-3-5 hypothetical protein YP_001744318.1 2292197 D 439855 CDS YP_001744319.1 170680531 6143356 2292408..2292560 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2292560 6143356 EcSMS35_2271 Escherichia coli SMS-3-5 hypothetical protein YP_001744319.1 2292408 D 439855 CDS YP_001744320.1 170679893 6144701 2292586..2294205 1 NC_010498.1 identified by match to protein family HMM PF01610; ISL3 family transposase 2294205 6144701 EcSMS35_2272 Escherichia coli SMS-3-5 ISL3 family transposase YP_001744320.1 2292586 D 439855 CDS YP_001744321.1 170682560 6143980 complement(2295950..2296513) 1 NC_010498.1 identified by similarity to GB:AAL08430.1; hypothetical protein 2296513 6143980 EcSMS35_2274 Escherichia coli SMS-3-5 hypothetical protein YP_001744321.1 2295950 R 439855 CDS YP_001744322.1 170682832 6146763 complement(2297723..2299546) 1 NC_010498.1 identified by similarity to GB:AAL08429.1; hypothetical protein 2299546 6146763 EcSMS35_2275 Escherichia coli SMS-3-5 hypothetical protein YP_001744322.1 2297723 R 439855 CDS YP_001744323.1 170682431 6147043 2299911..2301476 1 NC_010498.1 identified by similarity to GB:AAL08427.1; hypothetical protein 2301476 6147043 EcSMS35_2276 Escherichia coli SMS-3-5 hypothetical protein YP_001744323.1 2299911 D 439855 CDS YP_001744324.1 170680457 6146630 complement(2301700..2302908) 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 2302908 6146630 EcSMS35_2277 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001744324.1 2301700 R 439855 CDS YP_001744325.1 170679955 6144626 complement(2303366..2305642) 1 NC_010498.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 2305642 clpA 6144626 clpA Escherichia coli SMS-3-5 ATP-dependent Clp protease ATP-binding subunit YP_001744325.1 2303366 R 439855 CDS YP_001744326.1 170683903 6144117 complement(2305673..2305993) 1 NC_010498.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 2305993 clpS 6144117 clpS Escherichia coli SMS-3-5 ATP-dependent Clp protease adaptor protein ClpS YP_001744326.1 2305673 R 439855 CDS YP_001744327.1 170683368 6143199 2306316..2306540 1 NC_010498.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 2306540 cspD 6143199 cspD Escherichia coli SMS-3-5 stationary phase/starvation inducible regulatory protein CspD YP_001744327.1 2306316 D 439855 CDS YP_001744328.1 170683653 6142654 complement(2306613..2308559) 1 NC_010498.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 2308559 macB 6142654 macB Escherichia coli SMS-3-5 macrolide transporter ATP-binding /permease YP_001744328.1 2306613 R 439855 CDS YP_001744329.1 170683052 6142945 complement(2308556..2309671) 1 NC_010498.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 2309671 macA 6142945 macA Escherichia coli SMS-3-5 macrolide transporter subunit MacA YP_001744329.1 2308556 R 439855 CDS YP_001744330.1 170680310 6147268 2309786..2310778 1 NC_010498.1 identified by match to protein family HMM PF04393; hypothetical protein 2310778 6147268 EcSMS35_2284 Escherichia coli SMS-3-5 hypothetical protein YP_001744330.1 2309786 D 439855 CDS YP_001744331.1 170682448 6144478 complement(2310775..2312433) 1 NC_010498.1 hypothetical protein 2312433 6144478 EcSMS35_2283 Escherichia coli SMS-3-5 hypothetical protein YP_001744331.1 2310775 R 439855 CDS YP_001744332.1 170684199 6146647 2312859..2313554 1 NC_010498.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 2313554 aqpZ 6146647 aqpZ Escherichia coli SMS-3-5 aquaporin Z YP_001744332.1 2312859 D 439855 CDS YP_001744333.1 170682362 6143500 complement(2314068..2315093) 1 NC_010498.1 identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS110 family transposase 2315093 6143500 EcSMS35_2286 Escherichia coli SMS-3-5 IS110 family transposase YP_001744333.1 2314068 R 439855 CDS YP_001744334.1 170680883 6146561 complement(2315324..2316271) 1 NC_010498.1 identified by match to protein family HMM PF01207; tRNA-dihydrouridine synthase C 2316271 dusC 6146561 dusC Escherichia coli SMS-3-5 tRNA-dihydrouridine synthase C YP_001744334.1 2315324 R 439855 CDS YP_001744335.1 170681362 6145061 2316510..2316908 1 NC_010498.1 identified by match to protein family HMM PF03788; hypothetical protein 2316908 6145061 EcSMS35_2288 Escherichia coli SMS-3-5 hypothetical protein YP_001744335.1 2316510 D 439855 CDS YP_001744336.1 170679809 6145546 2316905..2317600 1 NC_010498.1 identified by match to protein family HMM PF04172; match to protein family HMM TIGR00659; hypothetical protein 2317600 6145546 EcSMS35_2289 Escherichia coli SMS-3-5 hypothetical protein YP_001744336.1 2316905 D 439855 CDS YP_001744337.1 170680352 6143970 2317730..2318614 1 NC_010498.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2318614 cdd 6143970 cdd Escherichia coli SMS-3-5 cytidine deaminase YP_001744337.1 2317730 D 439855 CDS YP_001744338.1 170683493 6144520 2318764..2319483 1 NC_010498.1 identified by match to protein family HMM PF02698; hypothetical protein 2319483 sanA 6144520 sanA Escherichia coli SMS-3-5 hypothetical protein YP_001744338.1 2318764 D 439855 CDS YP_001744339.1 170684176 6142782 2319486..2319725 1 NC_010498.1 hypothetical protein 2319725 6142782 EcSMS35_2292 Escherichia coli SMS-3-5 hypothetical protein YP_001744339.1 2319486 D 439855 CDS YP_001744340.1 170683988 6143477 2319919..2321157 1 NC_010498.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2321157 6143477 EcSMS35_2293 Escherichia coli SMS-3-5 putative oxidoreductase YP_001744340.1 2319919 D 439855 CDS YP_001744341.1 170682869 6143286 2321151..2322386 1 NC_010498.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2322386 6143286 EcSMS35_2294 Escherichia coli SMS-3-5 dihydropyrimidine dehydrogenase YP_001744341.1 2321151 D 439855 CDS YP_001744342.1 170680415 6147082 complement(2322457..2323467) 1 NC_010498.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2323467 mglC 6147082 mglC Escherichia coli SMS-3-5 beta-methylgalactoside transporter inner membrane component YP_001744342.1 2322457 R 439855 CDS YP_001744343.1 170679772 6144584 complement(2323483..2325003) 1 NC_010498.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2325003 mglA 6144584 mglA Escherichia coli SMS-3-5 galactose/methyl galaxtoside transporter ATP-binding protein YP_001744343.1 2323483 R 439855 CDS YP_001744344.1 170680313 6143931 complement(2325064..2326062) 1 NC_010498.1 identified by match to protein family HMM PF00532; galactose ABC transporter periplasmic galactose-binding protein 2326062 mglB 6143931 mglB Escherichia coli SMS-3-5 galactose ABC transporter periplasmic galactose-binding protein YP_001744344.1 2325064 R 439855 CDS YP_001744345.1 170679819 6144481 complement(2326342..2327382) 1 NC_010498.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2327382 galS 6144481 galS Escherichia coli SMS-3-5 DNA-binding transcriptional regulator GalS YP_001744345.1 2326342 R 439855 CDS YP_001744346.1 170681337 6143981 complement(2327524..2328681) 1 NC_010498.1 identified by match to protein family HMM PF04171; match to protein family HMM PF04235; hypothetical protein 2328681 6143981 EcSMS35_2299 Escherichia coli SMS-3-5 hypothetical protein YP_001744346.1 2327524 R 439855 CDS YP_001744347.1 170680773 6145521 complement(2328698..2329366) 1 NC_010498.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2329366 folE 6145521 folE Escherichia coli SMS-3-5 GTP cyclohydrolase I YP_001744347.1 2328698 R 439855 CDS YP_001744348.1 170682901 6144948 2329623..2330459 1 NC_010498.1 identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821; S-formylglutathione hydrolase 2330459 fghA1 6144948 fghA1 Escherichia coli SMS-3-5 S-formylglutathione hydrolase YP_001744348.1 2329623 D 439855 CDS YP_001744349.1 170682371 6147114 complement(2330491..2332416) 1 NC_010498.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2332416 cirA 6147114 cirA Escherichia coli SMS-3-5 colicin I receptor YP_001744349.1 2330491 R 439855 CDS YP_001744350.1 170679799 6146570 complement(2332774..2334243) 1 NC_010498.1 identified by match to protein family HMM PF00324; lysine transporter 2334243 lysP 6146570 lysP Escherichia coli SMS-3-5 lysine transporter YP_001744350.1 2332774 R 439855 CDS YP_001744351.1 170682677 6143959 complement(2334448..2335329) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 2335329 6143959 EcSMS35_2304 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001744351.1 2334448 R 439855 CDS YP_001744352.1 170681096 6146885 2335428..2336477 1 NC_010498.1 identified by match to protein family HMM PF03601; match to protein family HMM TIGR00698; hypothetical protein 2336477 6146885 EcSMS35_2305 Escherichia coli SMS-3-5 hypothetical protein YP_001744352.1 2335428 D 439855 CDS YP_001744353.1 170681734 6145278 2336551..2337408 1 NC_010498.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2337408 nfo 6145278 nfo Escherichia coli SMS-3-5 endonuclease IV YP_001744353.1 2336551 D 439855 CDS YP_001744354.1 170683507 6145923 2337411..2338499 1 NC_010498.1 identified by match to protein family HMM PF00294; match to protein family HMM PF08279; hypothetical protein 2338499 6145923 EcSMS35_2307 Escherichia coli SMS-3-5 hypothetical protein YP_001744354.1 2337411 D 439855 CDS YP_001744355.1 170684054 6142796 complement(2338555..2339805) 1 NC_010498.1 identified by match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; NupC family nucleoside transporter 2339805 6142796 EcSMS35_2308 Escherichia coli SMS-3-5 NupC family nucleoside transporter YP_001744355.1 2338555 R 439855 CDS YP_001744356.1 170683370 6143353 complement(2339905..2340846) 1 NC_010498.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2340846 rihB 6143353 rihB Escherichia coli SMS-3-5 ribonucleoside hydrolase 2 YP_001744356.1 2339905 R 439855 CDS YP_001744357.1 170683945 6142656 2340976..2341674 1 NC_010498.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2341674 nsr 6142656 nsr Escherichia coli SMS-3-5 DNA-binding transcriptional activator YeiL YP_001744357.1 2340976 D 439855 CDS YP_001744358.1 170681919 6143241 complement(2341742..2342992) 1 NC_010498.1 yeiM; identified by match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; NupC family nucleoside transporter 2342992 6143241 EcSMS35_2311 Escherichia coli SMS-3-5 NupC family nucleoside transporter YP_001744358.1 2341742 R 439855 CDS YP_001744359.1 170682601 6146114 complement(2343086..2344024) 1 NC_010498.1 identified by match to protein family HMM PF04227; indigoidine synthase A like protein 2344024 6146114 EcSMS35_2312 Escherichia coli SMS-3-5 indigoidine synthase A like protein YP_001744359.1 2343086 R 439855 CDS YP_001744360.1 170680599 6146806 complement(2344012..2344953) 1 NC_010498.1 identified by match to protein family HMM PF00294; hypothetical protein 2344953 6146806 EcSMS35_2313 Escherichia coli SMS-3-5 hypothetical protein YP_001744360.1 2344012 R 439855 CDS YP_001744361.1 170681268 6144771 complement(2345377..2347068) 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC 2347068 fruA 6144771 fruA Escherichia coli SMS-3-5 PTS system fructose-specific transporter subunits IIBC YP_001744361.1 2345377 R 439855 CDS YP_001744362.1 170681800 6145452 complement(2347085..2348023) 1 NC_010498.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2348023 fruK 6145452 fruK Escherichia coli SMS-3-5 1-phosphofructokinase YP_001744362.1 2347085 R 439855 CDS YP_001744363.1 170683388 6145993 complement(2348023..2349153) 1 NC_010498.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2349153 fruB 6145993 fruB Escherichia coli SMS-3-5 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_001744363.1 2348023 R 439855 CDS YP_001744364.1 170683990 6142674 2349319..2349450 1 NC_010498.1 hypothetical protein 2349450 6142674 EcSMS35_2317 Escherichia coli SMS-3-5 hypothetical protein YP_001744364.1 2349319 D 439855 CDS YP_001744365.1 170680537 6143288 2349521..2350702 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter B 2350702 setB 6143288 setB Escherichia coli SMS-3-5 sugar efflux transporter B YP_001744365.1 2349521 D 439855 CDS YP_001744366.1 170679926 6144707 complement(2350699..2350953) 1 NC_010498.1 identified by similarity to GB:CAH20558.1; hypothetical protein 2350953 6144707 EcSMS35_2318 Escherichia coli SMS-3-5 hypothetical protein YP_001744366.1 2350699 R 439855 CDS YP_001744367.1 170681704 6144088 2351108..2351680 1 NC_010498.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2351680 6144088 EcSMS35_2320 Escherichia coli SMS-3-5 elongation factor P YP_001744367.1 2351108 D 439855 CDS YP_001744368.1 170680151 6145890 2351903..2353369 1 NC_010498.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase family protein 2353369 6145890 EcSMS35_2321 Escherichia coli SMS-3-5 mannitol dehydrogenase family protein YP_001744368.1 2351903 D 439855 CDS YP_001744369.1 170681990 6144317 2353487..2354473 1 NC_010498.1 identified by match to protein family HMM PF02492; match to protein family HMM PF07683; CobW/P47K family protein 2354473 6144317 EcSMS35_2322 Escherichia coli SMS-3-5 CobW/P47K family protein YP_001744369.1 2353487 D 439855 CDS YP_001744370.1 170682623 6146186 2354512..2355225 1 NC_010498.1 identified by match to protein family HMM PF01569; PAP2 family protein 2355225 6146186 EcSMS35_2323 Escherichia coli SMS-3-5 PAP2 family protein YP_001744370.1 2354512 D 439855 CDS YP_001744371.1 170681203 6146829 2355637..2356203 1 NC_010498.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2356203 spr 6146829 spr Escherichia coli SMS-3-5 putative outer membrane lipoprotein YP_001744371.1 2355637 D 439855 CDS YP_001744372.1 170681845 6145387 2356384..2357940 1 NC_010498.1 identified by match to protein family HMM PF00563; hypothetical protein 2357940 6145387 EcSMS35_2325 Escherichia coli SMS-3-5 hypothetical protein YP_001744372.1 2356384 D 439855 CDS YP_001744373.1 170681154 6146038 2358022..2359836 1 NC_010498.1 identified by match to protein family HMM PF00496; ABC transporter periplasmic solute-binding protein 2359836 6146038 EcSMS35_2326 Escherichia coli SMS-3-5 ABC transporter periplasmic solute-binding protein YP_001744373.1 2358022 D 439855 CDS YP_001744374.1 170681691 6145337 2359837..2360931 1 NC_010498.1 identified by match to protein family HMM PF00528; ABC transporter permease 2360931 6145337 EcSMS35_2327 Escherichia coli SMS-3-5 ABC transporter permease YP_001744374.1 2359837 D 439855 CDS YP_001744375.1 170680077 6145877 2360931..2361956 1 NC_010498.1 identified by match to protein family HMM PF00528; ABC transporter permease 2361956 6145877 EcSMS35_2328 Escherichia coli SMS-3-5 ABC transporter permease YP_001744375.1 2360931 D 439855 CDS YP_001744376.1 170680600 6144241 2361958..2363547 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; ABC transporter ATP-binding protein 2363547 6144241 EcSMS35_2329 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001744376.1 2361958 D 439855 CDS YP_001744377.1 170682649 6144774 complement(2363551..2363895) 1 NC_010498.1 hypothetical protein 2363895 6144774 EcSMS35_2330 Escherichia coli SMS-3-5 hypothetical protein YP_001744377.1 2363551 R 439855 CDS YP_001744378.1 170683634 6146856 complement(2364229..2365419) 1 NC_010498.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2365419 bcr 6146856 bcr Escherichia coli SMS-3-5 bicyclomycin/multidrug efflux system YP_001744378.1 2364229 R 439855 CDS YP_001744379.1 170681582 6142925 complement(2365447..2366142) 1 NC_010498.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2366142 rsuA 6142925 rsuA Escherichia coli SMS-3-5 16S rRNA pseudouridylate synthase A YP_001744379.1 2365447 R 439855 CDS YP_001744380.1 170682105 6145767 2366292..2368052 1 NC_010498.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851; putative helicase 2368052 6145767 EcSMS35_2333 Escherichia coli SMS-3-5 putative helicase YP_001744380.1 2366292 D 439855 CDS YP_001744381.1 170680132 6146303 2368177..2368461 1 NC_010498.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2368461 rplY 6146303 rplY Escherichia coli SMS-3-5 50S ribosomal protein L25 YP_001744381.1 2368177 D 439855 CDS YP_001744382.1 170680719 6144298 complement(2368600..2369607) 1 NC_010498.1 identified by match to protein family HMM PF04245; nucleoid-associated protein NdpA 2369607 ndpA 6144298 ndpA Escherichia coli SMS-3-5 nucleoid-associated protein NdpA YP_001744382.1 2368600 R 439855 CDS YP_001744383.1 170682652 6144894 complement(2369652..2369768) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2369768 6144894 EcSMS35_2336 Escherichia coli SMS-3-5 hypothetical protein YP_001744383.1 2369652 R 439855 CDS YP_001744384.1 170683474 6146859 2369789..2370016 1 NC_010498.1 identified by match to protein family HMM PF07208; hypothetical protein 2370016 6146859 EcSMS35_2337 Escherichia coli SMS-3-5 hypothetical protein YP_001744384.1 2369789 D 439855 CDS YP_001744385.1 170681591 6142763 2370036..2371796 1 NC_010498.1 identified by match to protein family HMM PF00884; sulfatase family protein 2371796 6142763 EcSMS35_2338 Escherichia coli SMS-3-5 sulfatase family protein YP_001744385.1 2370036 D 439855 CDS YP_001744386.1 170679777 6146200 2374961..2375608 1 NC_010498.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2375608 narP 6146200 narP Escherichia coli SMS-3-5 transcriptional regulator NarP YP_001744386.1 2374961 D 439855 CDS YP_001744387.1 170680448 6143936 complement(2375643..2376695) 1 NC_010498.1 identified by match to protein family HMM PF03918; cytochrome c-type biogenesis family protein 2376695 6143936 EcSMS35_2342 Escherichia coli SMS-3-5 cytochrome c-type biogenesis family protein YP_001744387.1 2375643 R 439855 CDS YP_001744388.1 170684059 6144617 complement(2376692..2377249) 1 NC_010498.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; match to protein family HMM TIGR00385; thiol:disulfide interchange protein DsbE 2377249 dsbE 6144617 dsbE Escherichia coli SMS-3-5 thiol:disulfide interchange protein DsbE YP_001744388.1 2376692 R 439855 CDS YP_001744389.1 170679920 6143358 complement(2377246..2379189) 1 NC_010498.1 identified by match to protein family HMM PF01578; match to protein family HMM TIGR00353; cytochrome c-type biogenesis protein CcmF 2379189 ccmF 6143358 ccmF Escherichia coli SMS-3-5 cytochrome c-type biogenesis protein CcmF YP_001744389.1 2377246 R 439855 CDS YP_001744390.1 170680024 6144082 complement(2379186..2379665) 1 NC_010498.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2379665 ccmE 6144082 ccmE Escherichia coli SMS-3-5 cytochrome c-type biogenesis protein CcmE YP_001744390.1 2379186 R 439855 CDS YP_001744391.1 170681750 6144187 complement(2379662..2379871) 1 NC_010498.1 identified by match to protein family HMM PF04995; match to protein family HMM TIGR03141; heme exporter protein D 2379871 ccmD 6144187 ccmD Escherichia coli SMS-3-5 heme exporter protein D YP_001744391.1 2379662 R 439855 CDS YP_001744392.1 170683112 6145940 complement(2379868..2380605) 1 NC_010498.1 identified by match to protein family HMM PF01578; match to protein family HMM TIGR01191; heme exporter protein C 2380605 ccmC 6145940 ccmC Escherichia coli SMS-3-5 heme exporter protein C YP_001744392.1 2379868 R 439855 CDS YP_001744393.1 170680661 6147331 complement(2380647..2381309) 1 NC_010498.1 identified by match to protein family HMM PF03379; match to protein family HMM TIGR01190; heme exporter protein CcmB 2381309 ccmB 6147331 ccmB Escherichia coli SMS-3-5 heme exporter protein CcmB YP_001744393.1 2380647 R 439855 CDS YP_001744394.1 170682203 6144836 complement(2381306..2381923) 1 NC_010498.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2381923 ccmA 6144836 ccmA Escherichia coli SMS-3-5 cytochrome c biogenesis protein CcmA YP_001744394.1 2381306 R 439855 CDS YP_001744395.1 170683912 6146402 complement(2381942..2382544) 1 NC_010498.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2382544 napC 6146402 napC Escherichia coli SMS-3-5 cytochrome c-type protein NapC YP_001744395.1 2381942 R 439855 CDS YP_001744396.1 170681658 6143208 complement(2382554..2383003) 1 NC_010498.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2383003 napB 6143208 napB Escherichia coli SMS-3-5 citrate reductase cytochrome c-type subunit YP_001744396.1 2382554 R 439855 CDS YP_001744397.1 170681157 6145844 complement(2383000..2383863) 1 NC_010498.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2383863 napH 6145844 napH Escherichia coli SMS-3-5 quinol dehydrogenase membrane component YP_001744397.1 2383000 R 439855 CDS YP_001744398.1 170680735 6145340 complement(2383850..2384545) 1 NC_010498.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2384545 napG 6145340 napG Escherichia coli SMS-3-5 quinol dehydrogenase periplasmic component YP_001744398.1 2383850 R 439855 CDS YP_001744399.1 170679943 6144910 complement(2384552..2387038) 1 NC_010498.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2387038 napA 6144910 napA Escherichia coli SMS-3-5 nitrate reductase catalytic subunit YP_001744399.1 2384552 R 439855 CDS YP_001744400.1 170683051 6144105 complement(2387035..2387298) 1 NC_010498.1 identified by match to protein family HMM PF03927; assembly protein for periplasmic nitrate reductase 2387298 napD 6144105 napD Escherichia coli SMS-3-5 assembly protein for periplasmic nitrate reductase YP_001744400.1 2387035 R 439855 CDS YP_001744401.1 170682644 6147267 complement(2387288..2387782) 1 NC_010498.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein 2387782 napF 6147267 napF Escherichia coli SMS-3-5 ferredoxin-type protein YP_001744401.1 2387288 R 439855 CDS YP_001744402.1 170680170 6146850 2387891..2388055 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2388055 6146850 EcSMS35_2357 Escherichia coli SMS-3-5 hypothetical protein YP_001744402.1 2387891 D 439855 CDS YP_001744403.1 170679765 6144336 2388190..2388678 1 NC_010498.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2388678 eco 6144336 eco Escherichia coli SMS-3-5 ecotin YP_001744403.1 2388190 D 439855 CDS YP_001744404.1 170684210 6143924 complement(2388828..2390474) 1 NC_010498.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2390474 mqo 6143924 mqo Escherichia coli SMS-3-5 malate:quinone oxidoreductase YP_001744404.1 2388828 R 439855 CDS YP_001744405.1 170683689 6143511 complement(2390692..2392335) 1 NC_010498.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component 2392335 6143511 EcSMS35_2360 Escherichia coli SMS-3-5 multidrug transporter membrane component/ATP-binding component YP_001744405.1 2390692 R 439855 CDS YP_001744406.1 170682238 6142981 complement(2392411..2393061) 1 NC_010498.1 identified by match to protein family HMM PF03171; match to protein family HMM TIGR00568; alkylated DNA repair protein AlkB 2393061 alkB 6142981 alkB Escherichia coli SMS-3-5 alkylated DNA repair protein AlkB YP_001744406.1 2392411 R 439855 CDS YP_001744407.1 170684032 6146437 complement(2393061..2394125) 1 NC_010498.1 identified by match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589; regulatory protein Ada 2394125 ada 6146437 ada Escherichia coli SMS-3-5 regulatory protein Ada YP_001744407.1 2393061 R 439855 CDS YP_001744408.1 170681131 6143331 complement(2394199..2395254) 1 NC_010498.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2395254 apbE 6143331 apbE Escherichia coli SMS-3-5 thiamine biosynthesis lipoprotein ApbE YP_001744408.1 2394199 R 439855 CDS YP_001744409.1 170680935 6145314 complement(2395366..2396460) 1 NC_010498.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2396460 ompC 6145314 ompC Escherichia coli SMS-3-5 outer membrane porin protein C YP_001744409.1 2395366 R 439855 CDS YP_001744410.1 170683966 6145116 2397199..2399871 1 NC_010498.1 identified by match to protein family HMM PF01627; match to protein family HMM PF02518; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2399871 yojN 6145116 yojN Escherichia coli SMS-3-5 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_001744410.1 2397199 D 439855 CDS YP_001744411.1 170682257 6143263 2399888..2400538 1 NC_010498.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2400538 rcsB 6143263 rcsB Escherichia coli SMS-3-5 transcriptional regulator RcsB YP_001744411.1 2399888 D 439855 CDS YP_001744412.1 170679899 6146456 complement(2400624..2403473) 1 NC_010498.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2403473 rcsC 6146456 rcsC Escherichia coli SMS-3-5 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_001744412.1 2400624 R 439855 CDS YP_001744413.1 170680522 6144061 2403640..2405466 1 NC_010498.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2405466 atoS 6144061 atoS Escherichia coli SMS-3-5 sensory histidine kinase AtoS YP_001744413.1 2403640 D 439855 CDS YP_001744414.1 170681202 6144692 2405463..2406848 1 NC_010498.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2406848 atoC 6144692 atoC Escherichia coli SMS-3-5 acetoacetate metabolism regulatory protein AtoC YP_001744414.1 2405463 D 439855 CDS YP_001744415.1 170681854 6145386 2407044..2407706 1 NC_010498.1 identified by match to protein family HMM PF01144; match to protein family HMM TIGR02429; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2407706 pcaI 6145386 pcaI Escherichia coli SMS-3-5 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_001744415.1 2407044 D 439855 CDS YP_001744416.1 170682047 6146048 2407706..2408356 1 NC_010498.1 identified by match to protein family HMM PF01144; match to protein family HMM TIGR02428; 3-oxoacid CoA-transferase, B subunit 2408356 6146048 EcSMS35_2371 Escherichia coli SMS-3-5 3-oxoacid CoA-transferase, B subunit YP_001744416.1 2407706 D 439855 CDS YP_001744417.1 170682719 6146244 2408353..2409675 1 NC_010498.1 identified by match to protein family HMM PF02667; match to protein family HMM TIGR00366; putative short chain fatty acid transporter 2409675 6146244 EcSMS35_2372 Escherichia coli SMS-3-5 putative short chain fatty acid transporter YP_001744417.1 2408353 D 439855 CDS YP_001744418.1 170683363 6146927 2409706..2410890 1 NC_010498.1 identified by match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; acetyl-CoA acetyltransferase 2410890 atoB 6146927 atoB Escherichia coli SMS-3-5 acetyl-CoA acetyltransferase YP_001744418.1 2409706 D 439855 CDS YP_001744419.1 170684048 6142649 complement(2410964..2411740) 1 NC_010498.1 hypothetical protein 2411740 6142649 EcSMS35_2374 Escherichia coli SMS-3-5 hypothetical protein YP_001744419.1 2410964 R 439855 CDS YP_001744420.1 170680053 6143347 complement(2411745..2413394) 1 NC_010498.1 hypothetical protein 2413394 6143347 EcSMS35_2375 Escherichia coli SMS-3-5 hypothetical protein YP_001744420.1 2411745 R 439855 CDS YP_001744421.1 170680850 6144217 complement(2413395..2417909) 1 NC_010498.1 identified by match to protein family HMM PF01835; match to protein family HMM PF07703; alpha-2-macroglobulin family protein 2417909 6144217 EcSMS35_2376 Escherichia coli SMS-3-5 alpha-2-macroglobulin family protein YP_001744421.1 2413395 R 439855 CDS YP_001744422.1 170681110 6145027 complement(2417933..2418556) 1 NC_010498.1 identified by match to protein family HMM PF06672; hypothetical protein 2418556 6145027 EcSMS35_2377 Escherichia coli SMS-3-5 hypothetical protein YP_001744422.1 2417933 R 439855 CDS YP_001744423.1 170682837 6145293 complement(2418553..2420241) 1 NC_010498.1 hypothetical protein 2420241 6145293 EcSMS35_2378 Escherichia coli SMS-3-5 hypothetical protein YP_001744423.1 2418553 R 439855 CDS YP_001744424.1 170681961 6147048 complement(2420390..2423017) 1 NC_010498.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2423017 gyrA 6147048 gyrA Escherichia coli SMS-3-5 DNA gyrase subunit A YP_001744424.1 2420390 R 439855 CDS YP_001744425.1 170684206 6146157 complement(2423517..2424719) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein 2424719 6146157 EcSMS35_2380 Escherichia coli SMS-3-5 mandelate racemase/muconate lactonizing enzyme family protein YP_001744425.1 2423517 R 439855 CDS YP_001744426.1 170683353 6143507 complement(2424732..2426060) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 2426060 6143507 EcSMS35_2381 Escherichia coli SMS-3-5 major facilitator transporter YP_001744426.1 2424732 R 439855 CDS YP_001744427.1 170680188 6142639 2426298..2426996 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 2426996 6142639 EcSMS35_2382 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001744427.1 2426298 D 439855 CDS YP_001744428.1 170680509 6144354 2427074..2427796 1 NC_010498.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2427796 ubiG 6144354 ubiG Escherichia coli SMS-3-5 3-demethylubiquinone-9 3-methyltransferase YP_001744428.1 2427074 D 439855 CDS YP_001744429.1 170679991 6144679 complement(2427935..2431699) 1 NC_010498.1 identified by match to protein family HMM PF02415; match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01376; match to protein family HMM TIGR01414; match to protein family HMM TIGR02601; adhesin 2431699 6144679 EcSMS35_2384 Escherichia coli SMS-3-5 adhesin YP_001744429.1 2427935 R 439855 CDS YP_001744430.1 170682262 6144153 2432395..2434680 1 NC_010498.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2434680 nrdA 6144153 nrdA Escherichia coli SMS-3-5 ribonucleotide-diphosphate reductase subunit alpha YP_001744430.1 2432395 D 439855 CDS YP_001744431.1 170682190 6146461 2434775..2435956 1 NC_010498.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2435956 nrdB 6146461 nrdB Escherichia coli SMS-3-5 ribonucleotide-diphosphate reductase subunit beta YP_001744431.1 2434775 D 439855 CDS YP_001744432.1 170682918 6146389 2435956..2436210 1 NC_010498.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2436210 6146389 EcSMS35_2387 Escherichia coli SMS-3-5 2Fe-2S ferredoxin YfaE YP_001744432.1 2435956 D 439855 CDS YP_001744433.1 170683449 6147132 complement(2436264..2436914) 1 NC_010498.1 identified by match to protein family HMM PF06293; hypothetical protein 2436914 6147132 EcSMS35_2388 Escherichia coli SMS-3-5 hypothetical protein YP_001744433.1 2436264 R 439855 CDS YP_001744434.1 170683695 6142736 complement(2436995..2438185) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 2438185 6142736 EcSMS35_2389 Escherichia coli SMS-3-5 major facilitator transporter YP_001744434.1 2436995 R 439855 CDS YP_001744435.1 170680085 6142987 2438337..2439236 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 2439236 6142987 EcSMS35_2390 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001744435.1 2438337 D 439855 CDS YP_001744436.1 170679810 6144249 complement(2439256..2440332) 1 NC_010498.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2440332 glpQ 6144249 glpQ Escherichia coli SMS-3-5 glycerophosphodiester phosphodiesterase YP_001744436.1 2439256 R 439855 CDS YP_001744437.1 170680293 6143971 complement(2440337..2441695) 1 NC_010498.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2441695 glpT 6143971 glpT Escherichia coli SMS-3-5 sn-glycerol-3-phosphate transporter YP_001744437.1 2440337 R 439855 CDS YP_001744438.1 170681702 6144461 2441967..2443595 1 NC_010498.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2443595 glpA 6144461 glpA Escherichia coli SMS-3-5 sn-glycerol-3-phosphate dehydrogenase subunit A YP_001744438.1 2441967 D 439855 CDS YP_001744439.1 170681464 6145888 2443585..2444844 1 NC_010498.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2444844 glpB 6145888 glpB Escherichia coli SMS-3-5 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_001744439.1 2443585 D 439855 CDS YP_001744440.1 170683880 6145649 2444841..2446031 1 NC_010498.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2446031 glpC 6145649 glpC Escherichia coli SMS-3-5 sn-glycerol-3-phosphate dehydrogenase subunit C YP_001744440.1 2444841 D 439855 CDS YP_001744441.1 170679950 6143175 2446056..2446181 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2446181 6143175 EcSMS35_2396 Escherichia coli SMS-3-5 hypothetical protein YP_001744441.1 2446056 D 439855 CDS YP_001744442.1 170680731 6144112 2446224..2447183 1 NC_010498.1 yfaD; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 2447183 6144112 EcSMS35_2397 Escherichia coli SMS-3-5 hypothetical protein YP_001744442.1 2446224 D 439855 CDS YP_001744443.1 170681046 6144906 2447196..2447381 1 NC_010498.1 hypothetical protein 2447381 6144906 EcSMS35_2398 Escherichia coli SMS-3-5 hypothetical protein YP_001744443.1 2447196 D 439855 CDS YP_001744444.1 170681725 6145227 complement(2447422..2448225) 1 NC_010498.1 identified by match to protein family HMM PF03328; putative aldolase 2448225 6145227 EcSMS35_2399 Escherichia coli SMS-3-5 putative aldolase YP_001744444.1 2447422 R 439855 CDS YP_001744445.1 170682702 6145913 complement(2448243..2449532) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 2449532 6145913 EcSMS35_2400 Escherichia coli SMS-3-5 major facilitator transporter YP_001744445.1 2448243 R 439855 CDS YP_001744446.1 170683394 6146910 complement(2449589..2450794) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein 2450794 6146910 EcSMS35_2401 Escherichia coli SMS-3-5 mandelate racemase/muconate lactonizing enzyme family protein YP_001744446.1 2449589 R 439855 CDS YP_001744447.1 170683760 6142680 complement(2450809..2451591) 1 NC_010498.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator 2451591 6142680 EcSMS35_2402 Escherichia coli SMS-3-5 IclR family transcriptional regulator YP_001744447.1 2450809 R 439855 CDS YP_001744448.1 170680019 6143052 complement(2451811..2453013) 1 NC_010498.1 identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR00200; competence damage-inducible protein A 2453013 6143052 EcSMS35_2403 Escherichia coli SMS-3-5 competence damage-inducible protein A YP_001744448.1 2451811 R 439855 CDS YP_001744449.1 170680698 6144182 complement(2453113..2453655) 1 NC_010498.1 identified by match to protein family HMM PF07437; outer membrane protein, YfaZ 2453655 6144182 EcSMS35_2404 Escherichia coli SMS-3-5 outer membrane protein, YfaZ YP_001744449.1 2453113 R 439855 CDS YP_001744450.1 170679641 6144873 2453996..2454358 1 NC_010498.1 identified by match to protein family HMM PF00293; NUDIX family hydrolase 2454358 6144873 EcSMS35_2405 Escherichia coli SMS-3-5 NUDIX family hydrolase YP_001744450.1 2453996 D 439855 CDS YP_001744451.1 170683969 6143798 complement(2454397..2454999) 1 NC_010498.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 2454999 6143798 EcSMS35_2406 Escherichia coli SMS-3-5 phosphoglycerate mutase family protein YP_001744451.1 2454397 R 439855 CDS YP_001744452.1 170683278 6143266 2455289..2456446 1 NC_010498.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2456446 arnB 6143266 arnB Escherichia coli SMS-3-5 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_001744452.1 2455289 D 439855 CDS YP_001744453.1 170683519 6147504 2456450..2457418 1 NC_010498.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2457418 arnC 6147504 arnC Escherichia coli SMS-3-5 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_001744453.1 2456450 D 439855 CDS YP_001744454.1 170682848 6142809 2457418..2459400 1 NC_010498.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2459400 arnA 6142809 arnA Escherichia coli SMS-3-5 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_001744454.1 2457418 D 439855 CDS YP_001744455.1 170682514 6147061 2459397..2460287 1 NC_010498.1 identified by match to protein family HMM PF01522; polysaccharide deacetylase domain-containing protein 2460287 6147061 EcSMS35_2410 Escherichia coli SMS-3-5 polysaccharide deacetylase domain-containing protein YP_001744455.1 2459397 D 439855 CDS YP_001744456.1 170681813 6146714 2460287..2461939 1 NC_010498.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2461939 arnT 6146714 arnT Escherichia coli SMS-3-5 4-amino-4-deoxy-L-arabinose transferase YP_001744456.1 2460287 D 439855 CDS YP_001744457.1 170680869 6146006 2461936..2462271 1 NC_010498.1 identified by match to protein family HMM PF00893; SMR family multidrug efflux pump 2462271 6146006 EcSMS35_2412 Escherichia coli SMS-3-5 SMR family multidrug efflux pump YP_001744457.1 2461936 D 439855 CDS YP_001744458.1 170679769 6145047 2462271..2462657 1 NC_010498.1 hypothetical protein 2462657 6145047 EcSMS35_2414 Escherichia coli SMS-3-5 hypothetical protein YP_001744458.1 2462271 D 439855 CDS YP_001744459.1 170680382 6143928 complement(2462651..2462917) 1 NC_010498.1 polymyxin B resistance protein pmrD 2462917 pmrD 6143928 pmrD Escherichia coli SMS-3-5 polymyxin B resistance protein pmrD YP_001744459.1 2462651 R 439855 CDS YP_001744460.1 170681866 6144551 complement(2463027..2464382) 1 NC_010498.1 identified by match to protein family HMM PF00501; match to protein family HMM TIGR01923; O-succinylbenzoic acid--CoA ligase 2464382 menE 6144551 menE Escherichia coli SMS-3-5 O-succinylbenzoic acid--CoA ligase YP_001744460.1 2463027 R 439855 CDS YP_001744461.1 170682552 6146060 complement(2464379..2465341) 1 NC_010498.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2465341 menC 6146060 menC Escherichia coli SMS-3-5 O-succinylbenzoate synthase YP_001744461.1 2464379 R 439855 CDS YP_001744462.1 170680498 6146754 complement(2465341..2466198) 1 NC_010498.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2466198 menB 6146754 menB Escherichia coli SMS-3-5 naphthoate synthase YP_001744462.1 2465341 R 439855 CDS YP_001744463.1 170679997 6144667 complement(2466213..2466971) 1 NC_010498.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 2466971 6144667 EcSMS35_2418 Escherichia coli SMS-3-5 acyl-CoA thioester hydrolase YfbB YP_001744463.1 2466213 R 439855 CDS YP_001744464.1 170683335 6144159 complement(2466968..2468638) 1 NC_010498.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2468638 menD 6144159 menD Escherichia coli SMS-3-5 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_001744464.1 2466968 R 439855 CDS YP_001744465.1 170680455 6142620 complement(2468727..2470022) 1 NC_010498.1 identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543; isochorismate synthase, menaquinone-specific 2470022 menF 6142620 menF Escherichia coli SMS-3-5 isochorismate synthase, menaquinone-specific YP_001744465.1 2468727 R 439855 CDS YP_001744466.1 170681985 6144624 complement(2470101..2470406) 1 NC_010498.1 identified by match to protein family HMM PF05957; hypothetical protein 2470406 6144624 EcSMS35_2421 Escherichia coli SMS-3-5 hypothetical protein YP_001744466.1 2470101 R 439855 CDS YP_001744467.1 170683825 6146181 complement(2470461..2470922) 1 NC_010498.1 identified by match to protein family HMM PF00583; hypothetical protein 2470922 6146181 EcSMS35_2422 Escherichia coli SMS-3-5 hypothetical protein YP_001744467.1 2470461 R 439855 CDS YP_001744468.1 170680744 6143119 2470969..2471904 1 NC_010498.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2471904 rnz 6143119 rnz Escherichia coli SMS-3-5 ribonuclease Z YP_001744468.1 2470969 D 439855 CDS YP_001744469.1 170680444 6144919 complement(2471894..2472067) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2472067 6144919 EcSMS35_2423 Escherichia coli SMS-3-5 hypothetical protein YP_001744469.1 2471894 R 439855 CDS YP_001744470.1 170681089 6147313 complement(2473374..2475140) 1 NC_010498.1 identified by match to protein family HMM PF00092; von Willebrand factor type A domain-containing protein 2475140 6147313 EcSMS35_2426 Escherichia coli SMS-3-5 von Willebrand factor type A domain-containing protein YP_001744470.1 2473374 R 439855 CDS YP_001744471.1 170681697 6145271 complement(2475130..2475264) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2475264 6145271 EcSMS35_2427 Escherichia coli SMS-3-5 hypothetical protein YP_001744471.1 2475130 R 439855 CDS YP_001744472.1 170681463 6145883 2475432..2476253 1 NC_010498.1 yfbL; identified by match to protein family HMM PF04389; M28 family peptidase 2476253 6145883 EcSMS35_2428 Escherichia coli SMS-3-5 M28 family peptidase YP_001744472.1 2475432 D 439855 CDS YP_001744473.1 170680337 6145648 2476353..2476856 1 NC_010498.1 identified by match to protein family HMM PF08974; hypothetical protein 2476856 6145648 EcSMS35_2429 Escherichia coli SMS-3-5 hypothetical protein YP_001744473.1 2476353 D 439855 CDS YP_001744474.1 170683364 6144505 complement(2476924..2478381) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2478381 nuoN 6144505 nuoN Escherichia coli SMS-3-5 NADH dehydrogenase subunit N YP_001744474.1 2476924 R 439855 CDS YP_001744475.1 170683852 6142650 complement(2478388..2479917) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2479917 nuoM 6142650 nuoM Escherichia coli SMS-3-5 NADH dehydrogenase subunit M YP_001744475.1 2478388 R 439855 CDS YP_001744476.1 170682426 6143146 complement(2480081..2481916) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2481916 nuoL 6143146 nuoL Escherichia coli SMS-3-5 NADH dehydrogenase subunit L YP_001744476.1 2480081 R 439855 CDS YP_001744477.1 170681200 6146625 complement(2481919..2482221) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2482221 nuoK 6146625 nuoK Escherichia coli SMS-3-5 NADH dehydrogenase subunit K YP_001744477.1 2481919 R 439855 CDS YP_001744478.1 170681867 6145384 complement(2482218..2482772) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2482772 nuoJ 6145384 nuoJ Escherichia coli SMS-3-5 NADH dehydrogenase subunit J YP_001744478.1 2482218 R 439855 CDS YP_001744479.1 170681076 6146061 complement(2482784..2483326) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2483326 nuoI 6146061 nuoI Escherichia coli SMS-3-5 NADH dehydrogenase subunit I YP_001744479.1 2482784 R 439855 CDS YP_001744480.1 170681794 6145258 complement(2483341..2484318) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2484318 nuoH 6145258 nuoH Escherichia coli SMS-3-5 NADH dehydrogenase subunit H YP_001744480.1 2483341 R 439855 CDS YP_001744481.1 170680130 6145987 complement(2484315..2487041) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2487041 nuoG 6145987 nuoG Escherichia coli SMS-3-5 NADH dehydrogenase subunit G YP_001744481.1 2484315 R 439855 CDS YP_001744482.1 170680196 6144296 complement(2487094..2488431) 1 NC_010498.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2488431 nuoF 6144296 nuoF Escherichia coli SMS-3-5 NADH dehydrogenase I subunit F YP_001744482.1 2487094 R 439855 CDS YP_001744483.1 170683908 6144362 complement(2488428..2488928) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2488928 nuoE 6144362 nuoE Escherichia coli SMS-3-5 NADH dehydrogenase subunit E YP_001744483.1 2488428 R 439855 CDS YP_001744484.1 170682181 6143204 complement(2488931..2490733) 1 NC_010498.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2490733 nuoC 6143204 nuoC Escherichia coli SMS-3-5 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_001744484.1 2488931 R 439855 CDS YP_001744485.1 170681065 6146380 complement(2490827..2491489) 1 NC_010498.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2491489 nuoB 6146380 nuoB Escherichia coli SMS-3-5 NADH dehydrogenase subunit B YP_001744485.1 2490827 R 439855 CDS YP_001744486.1 170681754 6145247 complement(2491505..2491948) 1 NC_010498.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2491948 nuoA 6145247 nuoA Escherichia coli SMS-3-5 NADH dehydrogenase subunit A YP_001744486.1 2491505 R 439855 CDS YP_001744487.1 170681770 6145944 2491920..2492051 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2492051 6145944 EcSMS35_2443 Escherichia coli SMS-3-5 hypothetical protein YP_001744487.1 2491920 D 439855 CDS YP_001744488.1 170680027 6145962 complement(2492578..2493516) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator LrhA 2493516 lrhA 6145962 lrhA Escherichia coli SMS-3-5 transcriptional regulator LrhA YP_001744488.1 2492578 R 439855 CDS YP_001744489.1 170681539 6144190 2494436..2495653 1 NC_010498.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2495653 6144190 EcSMS35_2445 Escherichia coli SMS-3-5 aminotransferase AlaT YP_001744489.1 2494436 D 439855 CDS YP_001744490.1 170682233 6145724 2495737..2496336 1 NC_010498.1 identified by match to protein family HMM PF01966; hypothetical protein 2496336 yfbR 6145724 yfbR Escherichia coli SMS-3-5 hypothetical protein YP_001744490.1 2495737 D 439855 CDS YP_001744491.1 170680266 6146432 complement(2496395..2498227) 1 NC_010498.1 identified by match to protein family HMM PF02080; match to protein family HMM PF03600; match to protein family HMM PF06808; putative transporter 2498227 6146432 EcSMS35_2447 Escherichia coli SMS-3-5 putative transporter YP_001744491.1 2496395 R 439855 CDS YP_001744492.1 170680905 6144433 complement(2498314..2498964) 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; putative phosphatase 2498964 yfbT 6144433 yfbT Escherichia coli SMS-3-5 putative phosphatase YP_001744492.1 2498314 R 439855 CDS YP_001744493.1 170679627 6145084 complement(2498975..2499469) 1 NC_010498.1 identified by match to protein family HMM PF03887; hypothetical protein 2499469 6145084 EcSMS35_2449 Escherichia coli SMS-3-5 hypothetical protein YP_001744493.1 2498975 R 439855 CDS YP_001744494.1 170680286 6143784 complement(2499552..2500007) 1 NC_010498.1 identified by match to protein family HMM PF04217; hypothetical protein 2500007 6143784 EcSMS35_2450 Escherichia coli SMS-3-5 hypothetical protein YP_001744494.1 2499552 R 439855 CDS YP_001744495.1 170682938 6144453 complement(2500076..2500207) 1 NC_010498.1 hypothetical protein 2500207 6144453 EcSMS35_2451 Escherichia coli SMS-3-5 hypothetical protein YP_001744495.1 2500076 R 439855 CDS YP_001744496.1 170683672 6147152 2500345..2501547 1 NC_010498.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2501547 ackA 6147152 ackA Escherichia coli SMS-3-5 acetate kinase YP_001744496.1 2500345 D 439855 CDS YP_001744497.1 170680981 6142964 2501622..2503766 1 NC_010498.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2503766 pta 6142964 pta Escherichia coli SMS-3-5 phosphate acetyltransferase YP_001744497.1 2501622 D 439855 CDS YP_001744498.1 170681615 6145162 2503935..2505476 1 NC_010498.1 identified by match to protein family HMM PF03606; hypothetical protein 2505476 6145162 EcSMS35_2454 Escherichia coli SMS-3-5 hypothetical protein YP_001744498.1 2503935 D 439855 CDS YP_001744499.1 170680536 6145800 complement(2505509..2506051) 1 NC_010498.1 identified by match to protein family HMM PF00293; NUDIX family hydrolase 2506051 6145800 EcSMS35_2455 Escherichia coli SMS-3-5 NUDIX family hydrolase YP_001744499.1 2505509 R 439855 CDS YP_001744500.1 170680770 6144706 complement(2506109..2506660) 1 NC_010498.1 identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase 2506660 6144706 EcSMS35_2456 Escherichia coli SMS-3-5 phosphodiesterase YP_001744500.1 2506109 R 439855 CDS YP_001744501.1 170684150 6144945 complement(2506716..2507360) 1 NC_010498.1 identified by match to protein family HMM PF02798; glutathione S-transferase domain-containing protein 2507360 6144945 EcSMS35_2457 Escherichia coli SMS-3-5 glutathione S-transferase domain-containing protein YP_001744501.1 2506716 R 439855 CDS YP_001744502.1 170680007 6143450 2507497..2508144 1 NC_010498.1 yfcG; identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase 2508144 6143450 EcSMS35_2458 Escherichia coli SMS-3-5 glutathione S-transferase YP_001744502.1 2507497 D 439855 CDS YP_001744503.1 170683340 6144170 2508201..2508563 1 NC_010498.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2508563 folX 6144170 folX Escherichia coli SMS-3-5 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_001744503.1 2508201 D 439855 CDS YP_001744504.1 170683450 6142625 2508584..2509477 1 NC_010498.1 identified by match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM PF08338; match to protein family HMM TIGR01777; NAD-binding domain-containing protein 2509477 6142625 EcSMS35_2460 Escherichia coli SMS-3-5 NAD-binding domain-containing protein YP_001744504.1 2508584 D 439855 CDS YP_001744505.1 170681929 6142737 complement(2509525..2510427) 1 NC_010498.1 yfcI; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 2510427 6142737 EcSMS35_2461 Escherichia coli SMS-3-5 hypothetical protein YP_001744505.1 2509525 R 439855 CDS YP_001744506.1 170682608 6146125 complement(2510624..2511397) 1 NC_010498.1 identified by match to protein family HMM PF00005; histidine/lysine/arginine/ornithine transporter subunit 2511397 hisP 6146125 hisP Escherichia coli SMS-3-5 histidine/lysine/arginine/ornithine transporter subunit YP_001744506.1 2510624 R 439855 CDS YP_001744507.1 170679628 6146813 complement(2511405..2512121) 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; histidine ABC transporter permease HisM 2512121 hisM 6146813 hisM Escherichia coli SMS-3-5 histidine ABC transporter permease HisM YP_001744507.1 2511405 R 439855 CDS YP_001744508.1 170680291 6143785 complement(2512118..2512804) 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; histidine ABC transporter permease HisQ 2512804 hisQ 6143785 hisQ Escherichia coli SMS-3-5 histidine ABC transporter permease HisQ YP_001744508.1 2512118 R 439855 CDS YP_001744509.1 170680432 6144459 complement(2512894..2513676) 1 NC_010498.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; histidine ABC transporter periplasmic histidine-binding protein 2513676 hisJ 6144459 hisJ Escherichia coli SMS-3-5 histidine ABC transporter periplasmic histidine-binding protein YP_001744509.1 2512894 R 439855 CDS YP_001744510.1 170683333 6144601 complement(2513897..2514679) 1 NC_010498.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; lysine-arginine-ornithine-binding periplasmic protein 2514679 argT 6144601 argT Escherichia coli SMS-3-5 lysine-arginine-ornithine-binding periplasmic protein YP_001744510.1 2513897 R 439855 CDS YP_001744511.1 170683430 6142618 complement(2514945..2515514) 1 NC_010498.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2515514 ubiX 6142618 ubiX Escherichia coli SMS-3-5 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_001744511.1 2514945 R 439855 CDS YP_001744512.1 170684103 6142717 complement(2515609..2517126) 1 NC_010498.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2517126 purF 6142717 purF Escherichia coli SMS-3-5 amidophosphoribosyltransferase YP_001744512.1 2515609 R 439855 CDS YP_001744513.1 170681612 6143403 complement(2517163..2517651) 1 NC_010498.1 membrane protein required for colicin V production; colicin V production protein 2517651 cvpA 6143403 cvpA Escherichia coli SMS-3-5 colicin V production protein YP_001744513.1 2517163 R 439855 CDS YP_001744514.1 170681548 6145797 complement(2517887..2518549) 1 NC_010498.1 identified by match to protein family HMM PF05036; hypothetical protein 2518549 6145797 EcSMS35_2470 Escherichia coli SMS-3-5 hypothetical protein YP_001744514.1 2517887 R 439855 CDS YP_001744515.1 170682976 6145733 complement(2518539..2519807) 1 NC_010498.1 identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2519807 folC 6145733 folC Escherichia coli SMS-3-5 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_001744515.1 2518539 R 439855 CDS YP_001744516.1 170683472 6147191 complement(2519877..2520791) 1 NC_010498.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2520791 accD 6147191 accD Escherichia coli SMS-3-5 acetyl-CoA carboxylase subunit beta YP_001744516.1 2519877 R 439855 CDS YP_001744517.1 170684287 6142761 complement(2520947..2521606) 1 NC_010498.1 identified by match to protein family HMM PF09335; hypothetical protein 2521606 6142761 EcSMS35_2473 Escherichia coli SMS-3-5 hypothetical protein YP_001744517.1 2520947 R 439855 CDS YP_001744518.1 170680088 6143589 complement(2521689..2522501) 1 NC_010498.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2522501 truA 6143589 truA Escherichia coli SMS-3-5 tRNA pseudouridine synthase A YP_001744518.1 2521689 R 439855 CDS YP_001744519.1 170680975 6144252 complement(2522501..2523514) 1 NC_010498.1 identified by match to protein family HMM PF01118; match to protein family HMM PF02774; putative semialdehyde dehydrogenase 2523514 6144252 EcSMS35_2475 Escherichia coli SMS-3-5 putative semialdehyde dehydrogenase YP_001744519.1 2522501 R 439855 CDS YP_001744520.1 170679714 6145156 2523495..2523608 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2523608 6145156 EcSMS35_2477 Escherichia coli SMS-3-5 hypothetical protein YP_001744520.1 2523495 D 439855 CDS YP_001744521.1 170681474 6143872 complement(2523580..2524716) 1 NC_010498.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826; erythronate-4-phosphate dehydrogenase 2524716 pdxB 6143872 pdxB Escherichia coli SMS-3-5 erythronate-4-phosphate dehydrogenase YP_001744521.1 2523580 R 439855 CDS YP_001744522.1 170683243 6145659 2524815..2525810 1 NC_010498.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2525810 flk 6145659 flk Escherichia coli SMS-3-5 flagella biosynthesis regulator YP_001744522.1 2524815 D 439855 CDS YP_001744523.1 170682781 6147466 complement(2525807..2526985) 1 NC_010498.1 identified by match to protein family HMM PF07690; hypothetical protein 2526985 6147466 EcSMS35_2478 Escherichia coli SMS-3-5 hypothetical protein YP_001744523.1 2525807 R 439855 CDS YP_001744524.1 170683941 6146990 complement(2527217..2528437) 1 NC_010498.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 2528437 fabB 6146990 fabB Escherichia coli SMS-3-5 3-oxoacyl-(acyl carrier protein) synthase I YP_001744524.1 2527217 R 439855 CDS YP_001744525.1 170682200 6143237 2528596..2530602 1 NC_010498.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2530602 mnmC 6143237 mnmC Escherichia coli SMS-3-5 5-methylaminomethyl-2-thiouridine methyltransferase YP_001744525.1 2528596 D 439855 CDS YP_001744526.1 170682750 6146399 complement(2530658..2530936) 1 NC_010498.1 identified by match to protein family HMM PF08891; hypothetical protein 2530936 6146399 EcSMS35_2482 Escherichia coli SMS-3-5 hypothetical protein YP_001744526.1 2530658 R 439855 CDS YP_001744527.1 170681036 6146959 complement(2530970..2531518) 1 NC_010498.1 identified by match to protein family HMM PF04315; hypothetical protein 2531518 6146959 EcSMS35_2483 Escherichia coli SMS-3-5 hypothetical protein YP_001744527.1 2530970 R 439855 CDS YP_001744528.1 170681877 6145217 complement(2531518..2532327) 1 NC_010498.1 identified by match to protein family HMM PF01925; hypothetical protein 2532327 6145217 EcSMS35_2484 Escherichia coli SMS-3-5 hypothetical protein YP_001744528.1 2531518 R 439855 CDS YP_001744529.1 170680002 6146071 complement(2532327..2533151) 1 NC_010498.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2533151 mepA 6146071 mepA Escherichia coli SMS-3-5 penicillin-insensitive murein endopeptidase YP_001744529.1 2532327 R 439855 CDS YP_001744530.1 170680943 6144165 complement(2533155..2534240) 1 NC_010498.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2534240 aroC 6144165 aroC Escherichia coli SMS-3-5 chorismate synthase YP_001744530.1 2533155 R 439855 CDS YP_001744531.1 170681331 6145124 complement(2534275..2535207) 1 NC_010498.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2535207 prmB 6145124 prmB Escherichia coli SMS-3-5 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001744531.1 2534275 R 439855 CDS YP_001744532.1 170682882 6145515 2535373..2535924 1 NC_010498.1 identified by match to protein family HMM PF01713; hypothetical protein 2535924 6145515 EcSMS35_2488 Escherichia coli SMS-3-5 hypothetical protein YP_001744532.1 2535373 D 439855 CDS YP_001744533.1 170684247 6147095 2536010..2537368 1 NC_010498.1 SMC domain-containing protein 2537368 6147095 EcSMS35_2489 Escherichia coli SMS-3-5 SMC domain-containing protein YP_001744533.1 2536010 D 439855 CDS YP_001744534.1 170683579 6143549 2537352..2538011 1 NC_010498.1 hypothetical protein 2538011 6143549 EcSMS35_2490 Escherichia coli SMS-3-5 hypothetical protein YP_001744534.1 2537352 D 439855 CDS YP_001744535.1 170680246 6142870 complement(2538053..2538892) 1 NC_010498.1 yfcO; identified by similarity to GB:AAN81328.1; hypothetical protein 2538892 6142870 EcSMS35_2491 Escherichia coli SMS-3-5 hypothetical protein YP_001744535.1 2538053 R 439855 CDS YP_001744536.1 170679590 6144413 complement(2538894..2539418) 1 NC_010498.1 yfcP; identified by match to protein family HMM PF00419; putative minor fimbrial subunit 2539418 6144413 EcSMS35_2492 Escherichia coli SMS-3-5 putative minor fimbrial subunit YP_001744536.1 2538894 R 439855 CDS YP_001744537.1 170683842 6143747 complement(2539415..2539864) 1 NC_010498.1 yfcQ; putative minor fimbrial protein 2539864 6143747 EcSMS35_2493 Escherichia coli SMS-3-5 putative minor fimbrial protein YP_001744537.1 2539415 R 439855 CDS YP_001744538.1 170683183 6143136 complement(2539882..2540373) 1 NC_010498.1 yfcR; identified by similarity to GB:AAV76235.1; fimbrial protein 2540373 6143136 EcSMS35_2494 Escherichia coli SMS-3-5 fimbrial protein YP_001744538.1 2539882 R 439855 CDS YP_001744539.1 170680090 6147403 complement(2540390..2541142) 1 NC_010498.1 yfcS; identified by match to protein family HMM PF00345; fimbrial chaperone protein 2541142 6147403 EcSMS35_2495 Escherichia coli SMS-3-5 fimbrial chaperone protein YP_001744539.1 2540390 R 439855 CDS YP_001744540.1 170679648 6144254 complement(2541162..2543810) 1 NC_010498.1 yfcU; identified by match to protein family HMM PF00577; fimbrial usher protein 2543810 6144254 EcSMS35_2496 Escherichia coli SMS-3-5 fimbrial usher protein YP_001744540.1 2541162 R 439855 CDS YP_001744541.1 170681149 6143805 complement(2543891..2544457) 1 NC_010498.1 yfcV; identified by similarity to GB:AAC64152.1; match to protein family HMM PF00419; fimbrial protein 2544457 6143805 EcSMS35_2497 Escherichia coli SMS-3-5 fimbrial protein YP_001744541.1 2543891 R 439855 CDS YP_001744542.1 170681812 6145332 complement(2545025..2545510) 1 NC_010498.1 identified by similarity to SP:P76502; match to protein family HMM PF00300; match to protein family HMM TIGR00249; phosphohistidine phosphatase 2545510 sixA 6145332 sixA Escherichia coli SMS-3-5 phosphohistidine phosphatase YP_001744542.1 2545025 R 439855 CDS YP_001744543.1 170682174 6146005 2545487..2545639 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2545639 6146005 EcSMS35_2499 Escherichia coli SMS-3-5 hypothetical protein YP_001744543.1 2545487 D 439855 CDS YP_001744544.1 170682519 6146373 complement(2545713..2547857) 1 NC_010498.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2547857 fadJ 6146373 fadJ Escherichia coli SMS-3-5 multifunctional fatty acid oxidation complex subunit alpha YP_001744544.1 2545713 R 439855 CDS YP_001744545.1 170683369 6146720 complement(2547857..2549167) 1 NC_010498.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2549167 fadI 6146720 fadI Escherichia coli SMS-3-5 3-ketoacyl-CoA thiolase YP_001744545.1 2547857 R 439855 CDS YP_001744546.1 170683882 6142655 complement(2549348..2549632) 1 NC_010498.1 identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743; hypothetical protein 2549632 6142655 EcSMS35_2502 Escherichia coli SMS-3-5 hypothetical protein YP_001744546.1 2549348 R 439855 CDS YP_001744547.1 170683067 6143177 2550004..2551344 1 NC_010498.1 identified by match to protein family HMM PF03349; long-chain fatty acid outer membrane transporter 2551344 6143177 EcSMS35_2503 Escherichia coli SMS-3-5 long-chain fatty acid outer membrane transporter YP_001744547.1 2550004 D 439855 CDS YP_001744548.1 170682511 6147284 2551711..2552958 1 NC_010498.1 identified by similarity to GB:AAP17747.1; hypothetical protein 2552958 6147284 EcSMS35_2504 Escherichia coli SMS-3-5 hypothetical protein YP_001744548.1 2551711 D 439855 CDS YP_001744549.1 170681245 6146711 complement(2553137..2553892) 1 NC_010498.1 identified by match to protein family HMM PF04333; VacJ family lipoprotein 2553892 6146711 EcSMS35_2505 Escherichia coli SMS-3-5 VacJ family lipoprotein YP_001744549.1 2553137 R 439855 CDS YP_001744550.1 170680295 6145429 complement(2553918..2554031) 1 NC_010498.1 hypothetical protein 2554031 6145429 EcSMS35_2506 Escherichia coli SMS-3-5 hypothetical protein YP_001744550.1 2553918 R 439855 CDS YP_001744551.1 170681927 6144463 2554186..2555118 1 NC_010498.1 hypothetical protein 2555118 6144463 EcSMS35_2507 Escherichia coli SMS-3-5 hypothetical protein YP_001744551.1 2554186 D 439855 CDS YP_001744552.1 170681571 6143635 complement(2555706..2556236) 1 NC_010498.1 identified by match to protein family HMM PF03938; putative outer membrane protein 2556236 6143635 EcSMS35_2509 Escherichia coli SMS-3-5 putative outer membrane protein YP_001744552.1 2555706 R 439855 CDS YP_001744553.1 170683934 6145756 complement(2556284..2564197) 1 NC_010498.1 identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; match to protein family HMM TIGR02601; outer membrane autotransporter 2564197 6145756 EcSMS35_2510 Escherichia coli SMS-3-5 outer membrane autotransporter YP_001744553.1 2556284 R 439855 CDS YP_001744554.1 170680105 6143230 complement(2564222..2564842) 1 NC_010498.1 identified by match to protein family HMM PF00196; match to protein family HMM PF08281; LuxR family transcriptional regulator 2564842 6143230 EcSMS35_2511 Escherichia coli SMS-3-5 LuxR family transcriptional regulator YP_001744554.1 2564222 R 439855 CDS YP_001744555.1 170684056 6144269 complement(2565160..2565789) 1 NC_010498.1 identified by similarity to SP:P0ADH5; match to protein family HMM PF00589; type 1 fimbriae regulatory protein 2565789 6144269 EcSMS35_2512 Escherichia coli SMS-3-5 type 1 fimbriae regulatory protein YP_001744555.1 2565160 R 439855 CDS YP_001744556.1 170684288 6143355 2566538..2567107 1 NC_010498.1 identified by similarity to SP:P0ADH5; match to protein family HMM PF00589; type 1 fimbriae regulatory protein 2567107 6143355 EcSMS35_2513 Escherichia coli SMS-3-5 type 1 fimbriae regulatory protein YP_001744556.1 2566538 D 439855 CDS YP_001744557.1 170681753 6143590 complement(2567502..2568449) 1 NC_010498.1 regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC 2568449 dsdC 6143590 dsdC Escherichia coli SMS-3-5 DNA-binding transcriptional regulator DsdC YP_001744557.1 2567502 R 439855 CDS YP_001744558.1 170681070 6145943 2568667..2570004 1 NC_010498.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2570004 6145943 EcSMS35_2515 Escherichia coli SMS-3-5 permease DsdX YP_001744558.1 2568667 D 439855 CDS YP_001744559.1 170681826 6145252 2570037..2571353 1 NC_010498.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2571353 dsdA 6145252 dsdA Escherichia coli SMS-3-5 D-serine dehydratase YP_001744559.1 2570037 D 439855 CDS YP_001744560.1 170682814 6146019 complement(2571458..2572996) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; multidrug resistance protein Y 2572996 emrY 6146019 emrY Escherichia coli SMS-3-5 multidrug resistance protein Y YP_001744560.1 2571458 R 439855 CDS YP_001744561.1 170682886 6147025 complement(2572996..2574159) 1 NC_010498.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR00998; drug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK 2574159 emrK 6147025 emrK Escherichia coli SMS-3-5 drug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK YP_001744561.1 2572996 R 439855 CDS YP_001744562.1 170683753 6147099 2574575..2575189 1 NC_010498.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2575189 evgA 6147099 evgA Escherichia coli SMS-3-5 DNA-binding transcriptional activator EvgA YP_001744562.1 2574575 D 439855 CDS YP_001744563.1 170683263 6143045 2575404..2578787 1 NC_010498.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00497; match to protein family HMM PF00512; match to protein family HMM PF01627; match to protein family HMM PF02518; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2578787 evgS 6143045 evgS Escherichia coli SMS-3-5 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_001744563.1 2575404 D 439855 CDS YP_001744564.1 170680633 6147487 complement(2578843..2579988) 1 NC_010498.1 identified by match to protein family HMM PF02515; hypothetical protein 2579988 6147487 EcSMS35_2521 Escherichia coli SMS-3-5 hypothetical protein YP_001744564.1 2578843 R 439855 CDS YP_001744565.1 170680123 6144808 complement(2580062..2581006) 1 NC_010498.1 member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV 2581006 6144808 EcSMS35_2522 Escherichia coli SMS-3-5 putative transporter YfdV YP_001744565.1 2580062 R 439855 CDS YP_001744566.1 170682647 6144288 complement(2581075..2582769) 1 NC_010498.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 2582769 6144288 EcSMS35_2523 Escherichia coli SMS-3-5 putative oxalyl-CoA decarboxylase YP_001744566.1 2581075 R 439855 CDS YP_001744567.1 170682002 6146854 complement(2582823..2584073) 1 NC_010498.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2584073 frc 6146854 frc Escherichia coli SMS-3-5 formyl-coenzyme A transferase YP_001744567.1 2582823 R 439855 CDS YP_001744568.1 170683981 6146198 complement(2584585..2585208) 1 NC_010498.1 hypothetical protein 2585208 6146198 EcSMS35_2525 Escherichia coli SMS-3-5 hypothetical protein YP_001744568.1 2584585 R 439855 CDS YP_001744569.1 170679782 6143279 complement(2585437..2585562) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2585562 6143279 EcSMS35_2526 Escherichia coli SMS-3-5 hypothetical protein YP_001744569.1 2585437 R 439855 CDS YP_001744570.1 170681911 6143942 2585504..2585779 1 NC_010498.1 putative lipoprotein 2585779 6143942 EcSMS35_2527 Escherichia coli SMS-3-5 putative lipoprotein YP_001744570.1 2585504 D 439855 CDS YP_001744571.1 170683405 6146106 complement(2585856..2586098) 1 NC_010498.1 hypothetical protein 2586098 6146106 EcSMS35_2528 Escherichia coli SMS-3-5 hypothetical protein YP_001744571.1 2585856 R 439855 CDS YP_001744572.1 170680549 6142691 2586451..2587371 1 NC_010498.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2587371 6142691 EcSMS35_2529 Escherichia coli SMS-3-5 lipid A biosynthesis palmitoleoyl acyltransferase YP_001744572.1 2586451 D 439855 CDS YP_001744573.1 170683886 6144719 2587682..2587798 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2587798 6144719 EcSMS35_2530 Escherichia coli SMS-3-5 hypothetical protein YP_001744573.1 2587682 D 439855 CDS YP_001744574.1 170683338 6143181 complement(2587863..2589101) 1 NC_010498.1 identified by match to protein family HMM PF00155; aminotransferase 2589101 6143181 EcSMS35_2531 Escherichia coli SMS-3-5 aminotransferase YP_001744574.1 2587863 R 439855 CDS YP_001744575.1 170681499 6142623 2589496..2591175 1 NC_010498.1 identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694; sensor histidine kinase 2591175 6142623 EcSMS35_2532 Escherichia coli SMS-3-5 sensor histidine kinase YP_001744575.1 2589496 D 439855 CDS YP_001744576.1 170681029 6145684 2591190..2591924 1 NC_010498.1 identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 2591924 6145684 EcSMS35_2533 Escherichia coli SMS-3-5 response regulator YP_001744576.1 2591190 D 439855 CDS YP_001744577.1 170680686 6145210 2591937..2592794 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 2592794 6145210 EcSMS35_2534 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001744577.1 2591937 D 439855 CDS YP_001744578.1 170679733 6144861 complement(2592797..2595292) 1 NC_010498.1 identified by match to protein family HMM PF00359; match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR00848; match to protein family HMM TIGR01417; multiphosphoryl transfer protein 1 2595292 fryA 6144861 fryA Escherichia coli SMS-3-5 multiphosphoryl transfer protein 1 YP_001744578.1 2592797 R 439855 CDS YP_001744579.1 170679878 6143891 complement(2595317..2596354) 1 NC_010498.1 metalloprotein; exoaminopeptidase 2596354 6143891 EcSMS35_2536 Escherichia coli SMS-3-5 exoaminopeptidase YP_001744579.1 2595317 R 439855 CDS YP_001744580.1 170683336 6144040 complement(2596354..2597439) 1 NC_010498.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2597439 ypdF 6144040 ypdF Escherichia coli SMS-3-5 aminopeptidase YP_001744580.1 2596354 R 439855 CDS YP_001744581.1 170681226 6142621 complement(2597454..2598701) 1 NC_010498.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, fructose-like, IIC component 2598701 fryC 6142621 fryC Escherichia coli SMS-3-5 PTS system, fructose-like, IIC component YP_001744581.1 2597454 R 439855 CDS YP_001744582.1 170681868 6145410 complement(2598723..2599049) 1 NC_010498.1 identified by match to protein family HMM PF02379; match to protein family HMM TIGR00829; PTS system, fructose specific IIB subunit 2599049 6145410 EcSMS35_2539 Escherichia coli SMS-3-5 PTS system, fructose specific IIB subunit YP_001744582.1 2598723 R 439855 CDS YP_001744583.1 170681946 6146062 complement(2599268..2600233) 1 NC_010498.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2600233 glk 6146062 glk Escherichia coli SMS-3-5 glucokinase YP_001744583.1 2599268 R 439855 CDS YP_001744584.1 170682632 6146142 2600437..2601693 1 NC_010498.1 identified by match to protein family HMM PF00654; hypothetical protein 2601693 6146142 EcSMS35_2541 Escherichia coli SMS-3-5 hypothetical protein YP_001744584.1 2600437 D 439855 CDS YP_001744585.1 170683307 6146838 2601808..2602134 1 NC_010498.1 hypothetical protein 2602134 6146838 EcSMS35_2542 Escherichia coli SMS-3-5 hypothetical protein YP_001744585.1 2601808 D 439855 CDS YP_001744586.1 170683992 6147533 complement(2602202..2603440) 1 NC_010498.1 identified by match to protein family HMM PF01566; match to protein family HMM TIGR01197; manganese transport protein MntH 2603440 mntH 6147533 mntH Escherichia coli SMS-3-5 manganese transport protein MntH YP_001744586.1 2602202 R 439855 CDS YP_001744587.1 170683520 6143290 2603776..2604978 1 NC_010498.1 identified by similarity to SP:P0AFF2; match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; nucleoside transporter NupC 2604978 nupC 6143290 nupC Escherichia coli SMS-3-5 nucleoside transporter NupC YP_001744587.1 2603776 D 439855 CDS YP_001744588.1 170684005 6142810 complement(2605027..2607216) 1 NC_010498.1 identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM PF05231; diguanylate cyclase 2607216 6142810 EcSMS35_2545 Escherichia coli SMS-3-5 diguanylate cyclase YP_001744588.1 2605027 R 439855 CDS YP_001744589.1 170682613 6143698 2607850..2608194 1 NC_010498.1 hypothetical protein 2608194 6143698 EcSMS35_2548 Escherichia coli SMS-3-5 hypothetical protein YP_001744589.1 2607850 D 439855 CDS YP_001744590.1 170683302 6146818 2608196..2608588 1 NC_010498.1 identified by match to protein family HMM PF07037; hypothetical protein 2608588 6146818 EcSMS35_2549 Escherichia coli SMS-3-5 hypothetical protein YP_001744590.1 2608196 D 439855 CDS YP_001744591.1 170680101 6144761 2609909..2610064 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2610064 6144761 EcSMS35_2551 Escherichia coli SMS-3-5 hypothetical protein YP_001744591.1 2609909 D 439855 CDS YP_001744592.1 170679600 6144265 complement(2610388..2611803) 1 NC_010498.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2611803 gltX 6144265 gltX Escherichia coli SMS-3-5 glutamyl-tRNA synthetase YP_001744592.1 2610388 R 439855 CDS YP_001744593.1 170683827 6143757 2611807..2611938 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2611938 6143757 EcSMS35_2553 Escherichia coli SMS-3-5 hypothetical protein YP_001744593.1 2611807 D 439855 CDS YP_001744594.1 170683306 6143678 complement(2612570..2613454) 1 NC_010498.1 identified by similarity to SP:P23841; match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional activator XapR 2613454 xapR 6143678 xapR Escherichia coli SMS-3-5 DNA-binding transcriptional activator XapR YP_001744594.1 2612570 R 439855 CDS YP_001744595.1 170682831 6147532 complement(2613496..2613654) 1 NC_010498.1 identified by similarity to GB:AAX66324.1; match to protein family HMM TIGR03510; hypothetical protein 2613654 6147532 EcSMS35_2559 Escherichia coli SMS-3-5 hypothetical protein YP_001744595.1 2613496 R 439855 CDS YP_001744596.1 170682496 6147042 complement(2613707..2614963) 1 NC_010498.1 identified by similarity to SP:P45562; match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; xanthosine permease XapB 2614963 xapB 6147042 xapB Escherichia coli SMS-3-5 xanthosine permease XapB YP_001744596.1 2613707 R 439855 CDS YP_001744597.1 170683003 6146696 complement(2615024..2615857) 1 NC_010498.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 2615857 xapA 6146696 xapA Escherichia coli SMS-3-5 purine nucleoside phosphorylase YP_001744597.1 2615024 R 439855 CDS YP_001744598.1 170683485 6147219 2616106..2616870 1 NC_010498.1 yfeN; identified by match to protein family HMM PF07135; hypothetical protein 2616870 6147219 EcSMS35_2562 Escherichia coli SMS-3-5 hypothetical protein YP_001744598.1 2616106 D 439855 CDS YP_001744599.1 170684030 6142774 complement(2616908..2617834) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 2617834 6142774 EcSMS35_2563 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001744599.1 2616908 R 439855 CDS YP_001744600.1 170680783 6143329 2617924..2618922 1 NC_010498.1 bile acid/Na+ symporter family protein 2618922 6143329 EcSMS35_2565 Escherichia coli SMS-3-5 bile acid/Na+ symporter family protein YP_001744600.1 2617924 D 439855 CDS YP_001744601.1 170681427 6144958 complement(2618919..2619137) 1 NC_010498.1 hypothetical protein 2619137 6144958 EcSMS35_2564 Escherichia coli SMS-3-5 hypothetical protein YP_001744601.1 2618919 R 439855 CDS YP_001744602.1 170680446 6145611 complement(2619139..2621154) 1 NC_010498.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2621154 ligA 6145611 ligA Escherichia coli SMS-3-5 NAD-dependent DNA ligase LigA YP_001744602.1 2619139 R 439855 CDS YP_001744603.1 170679738 6144615 complement(2621225..2622223) 1 NC_010498.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2622223 zipA 6144615 zipA Escherichia coli SMS-3-5 cell division protein ZipA YP_001744603.1 2621225 R 439855 CDS YP_001744604.1 170684129 6143896 2622453..2623214 1 NC_010498.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 2623214 cysZ 6143896 cysZ Escherichia coli SMS-3-5 putative sulfate transport protein CysZ YP_001744604.1 2622453 D 439855 CDS YP_001744605.1 170683441 6143429 2623399..2624370 1 NC_010498.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2624370 cysK 6143429 cysK Escherichia coli SMS-3-5 cysteine synthase A YP_001744605.1 2623399 D 439855 CDS YP_001744606.1 170680194 6142728 2624754..2625011 1 NC_010498.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2625011 ptsH 6142728 ptsH Escherichia coli SMS-3-5 PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr YP_001744606.1 2624754 D 439855 CDS YP_001744607.1 170681013 6144360 2625056..2626783 1 NC_010498.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2626783 ptsI 6144360 ptsI Escherichia coli SMS-3-5 phosphoenolpyruvate-protein phosphotransferase YP_001744607.1 2625056 D 439855 CDS YP_001744608.1 170681855 6145194 2626824..2627333 1 NC_010498.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2627333 crr 6145194 crr Escherichia coli SMS-3-5 PTS system glucose-specific transporter subunit YP_001744608.1 2626824 D 439855 CDS YP_001744609.1 170682388 6146049 2627452..2628780 1 NC_010498.1 identified by match to protein family HMM PF01609; IS4 transposase 2628780 6146049 EcSMS35_2573 Escherichia coli SMS-3-5 IS4 transposase YP_001744609.1 2627452 D 439855 CDS YP_001744610.1 170682925 6146587 complement(2628814..2629665) 1 NC_010498.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2629665 pdxK 6146587 pdxK Escherichia coli SMS-3-5 pyridoxal kinase YP_001744610.1 2628814 R 439855 CDS YP_001744611.1 170683885 6147139 2629770..2630138 1 NC_010498.1 hypothetical protein 2630138 6147139 EcSMS35_2575 Escherichia coli SMS-3-5 hypothetical protein YP_001744611.1 2629770 D 439855 CDS YP_001744612.1 170684234 6143180 complement(2630141..2631052) 1 NC_010498.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2631052 cysM 6143180 cysM Escherichia coli SMS-3-5 cysteine synthase B YP_001744612.1 2630141 R 439855 CDS YP_001744613.1 170679900 6143535 complement(2631186..2632283) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR00968; sulfate/thiosulfate transporter subunit 2632283 cysA 6143535 cysA Escherichia coli SMS-3-5 sulfate/thiosulfate transporter subunit YP_001744613.1 2631186 R 439855 CDS YP_001744614.1 170681289 6144062 complement(2632273..2633148) 1 NC_010498.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2633148 cysW 6144062 cysW Escherichia coli SMS-3-5 sulfate/thiosulfate transporter permease subunit YP_001744614.1 2632273 R 439855 CDS YP_001744615.1 170681836 6145473 complement(2633148..2633981) 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02139; sulfate/thiosulfate transporter subunit 2633981 cysT 6145473 cysT Escherichia coli SMS-3-5 sulfate/thiosulfate transporter subunit YP_001744615.1 2633148 R 439855 CDS YP_001744616.1 170679837 6146029 complement(2633981..2634997) 1 NC_010498.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971; thiosulfate transporter subunit 2634997 cysP 6146029 cysP Escherichia coli SMS-3-5 thiosulfate transporter subunit YP_001744616.1 2633981 R 439855 CDS YP_001744617.1 170683796 6143999 complement(2635155..2635946) 1 NC_010498.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659; short chain dehydrogenase 2635946 ucpA 6143999 ucpA Escherichia coli SMS-3-5 short chain dehydrogenase YP_001744617.1 2635155 R 439855 CDS YP_001744618.1 170683537 6143089 complement(2636075..2636932) 1 NC_010498.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator 2636932 6143089 EcSMS35_2582 Escherichia coli SMS-3-5 RpiR family transcriptional regulator YP_001744618.1 2636075 R 439855 CDS YP_001744619.1 170682788 6142827 2637096..2637992 1 NC_010498.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2637992 murQ 6142827 murQ Escherichia coli SMS-3-5 N-acetylmuramic acid-6-phosphate etherase YP_001744619.1 2637096 D 439855 CDS YP_001744620.1 170681626 6146997 2637996..2639420 1 NC_010498.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2639420 murP 6146997 murP Escherichia coli SMS-3-5 PTS system N-acetylmuramic acid transporter subunits EIIBC YP_001744620.1 2637996 D 439855 CDS YP_001744621.1 170681143 6145811 2639425..2640726 1 NC_010498.1 identified by match to protein family HMM PF00144; hypothetical protein 2640726 6145811 EcSMS35_2585 Escherichia coli SMS-3-5 hypothetical protein YP_001744621.1 2639425 D 439855 CDS YP_001744622.1 170680598 6145326 complement(2640784..2641683) 1 NC_010498.1 identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413; dyp-type peroxidase family protein 2641683 6145326 EcSMS35_2586 Escherichia coli SMS-3-5 dyp-type peroxidase family protein YP_001744622.1 2640784 R 439855 CDS YP_001744623.1 170680240 6144770 complement(2641779..2642354) 1 NC_010498.1 identified by match to protein family HMM PF06572; hypothetical protein 2642354 6144770 EcSMS35_2587 Escherichia coli SMS-3-5 hypothetical protein YP_001744623.1 2641779 R 439855 CDS YP_001744624.1 170683815 6144407 complement(2642415..2642762) 1 NC_010498.1 putative inner membrane protein YfeZ 2642762 6144407 EcSMS35_2588 Escherichia coli SMS-3-5 putative inner membrane protein YfeZ YP_001744624.1 2642415 R 439855 CDS YP_001744625.1 170683142 6143109 complement(2642851..2643276) 1 NC_010498.1 identified by match to protein family HMM PF00583; putative acetyltransferase 2643276 6143109 EcSMS35_2589 Escherichia coli SMS-3-5 putative acetyltransferase YP_001744625.1 2642851 R 439855 CDS YP_001744626.1 170683652 6147362 2643490..2644359 1 NC_010498.1 identified by similarity to SP:P36548; match to protein family HMM PF01520; match to protein family HMM TIGR01409; N-acetylmuramoyl-l-alanine amidase I 2644359 amiA 6147362 amiA Escherichia coli SMS-3-5 N-acetylmuramoyl-l-alanine amidase I YP_001744626.1 2643490 D 439855 CDS YP_001744627.1 170679650 6142944 2644363..2645262 1 NC_010498.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2645262 hemF 6142944 hemF Escherichia coli SMS-3-5 coproporphyrinogen III oxidase YP_001744627.1 2644363 D 439855 CDS YP_001744628.1 170680296 6143807 complement(2645268..2646320) 1 NC_010498.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2646320 6143807 EcSMS35_2592 Escherichia coli SMS-3-5 transcriptional regulator EutR YP_001744628.1 2645268 R 439855 CDS YP_001744629.1 170680969 6144464 complement(2646366..2646866) 1 NC_010498.1 identified by match to protein family HMM PF00936; putative ethanolamine utilization protein EutK 2646866 6144464 EcSMS35_2593 Escherichia coli SMS-3-5 putative ethanolamine utilization protein EutK YP_001744629.1 2646366 R 439855 CDS YP_001744630.1 170681056 6145150 complement(2646879..2647538) 1 NC_010498.1 identified by match to protein family HMM PF00936; putative ethanolamine utilization protein EutL 2647538 6145150 EcSMS35_2594 Escherichia coli SMS-3-5 putative ethanolamine utilization protein EutL YP_001744630.1 2646879 R 439855 CDS YP_001744631.1 170683185 6145237 complement(2647548..2648435) 1 NC_010498.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2648435 eutC 6145237 eutC Escherichia coli SMS-3-5 ethanolamine ammonia-lyase small subunit YP_001744631.1 2647548 R 439855 CDS YP_001744632.1 170683706 6147405 complement(2648456..2649817) 1 NC_010498.1 identified by match to protein family HMM PF06751; ethanolamine ammonia-lyase, large subunit 2649817 eutB 6147405 eutB Escherichia coli SMS-3-5 ethanolamine ammonia-lyase, large subunit YP_001744632.1 2648456 R 439855 CDS YP_001744633.1 170680541 6142998 complement(2649829..2651232) 1 NC_010498.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2651232 eutA 6142998 eutA Escherichia coli SMS-3-5 reactivating factor for ethanolamine ammonia lyase YP_001744633.1 2649829 R 439855 CDS YP_001744634.1 170683597 6144711 complement(2651229..2652455) 1 NC_010498.1 identified by match to protein family HMM PF04346; ethanolamine utilization protein EutH 2652455 eutH 6144711 eutH Escherichia coli SMS-3-5 ethanolamine utilization protein EutH YP_001744634.1 2651229 R 439855 CDS YP_001744635.1 170681253 6142888 complement(2652625..2653812) 1 NC_010498.1 identified by match to protein family HMM PF00465; ethanolamine utilization protein EutG 2653812 eutG 6142888 eutG Escherichia coli SMS-3-5 ethanolamine utilization protein EutG YP_001744635.1 2652625 R 439855 CDS YP_001744636.1 170682604 6145437 complement(2653802..2654638) 1 NC_010498.1 identified by match to protein family HMM TIGR02529; ethanolamine utilization protein EutJ 2654638 eutJ 6145437 eutJ Escherichia coli SMS-3-5 ethanolamine utilization protein EutJ YP_001744636.1 2653802 R 439855 CDS YP_001744637.1 170681242 6146809 complement(2654649..2656052) 1 NC_010498.1 identified by match to protein family HMM PF00171; ethanolamine utilization protein EutE 2656052 eutE 6146809 eutE Escherichia coli SMS-3-5 ethanolamine utilization protein EutE YP_001744637.1 2654649 R 439855 CDS YP_001744638.1 170682952 6145426 complement(2656064..2656351) 1 NC_010498.1 identified by match to protein family HMM PF03319; ethanolamine utilization protein 2656351 eutN 6145426 eutN Escherichia coli SMS-3-5 ethanolamine utilization protein YP_001744638.1 2656064 R 439855 CDS YP_001744639.1 170679901 6147167 complement(2656458..2656751) 1 NC_010498.1 identified by match to protein family HMM PF00936; ethanolamine utilization protein EutM 2656751 eutM 6147167 eutM Escherichia coli SMS-3-5 ethanolamine utilization protein EutM YP_001744639.1 2656458 R 439855 CDS YP_001744640.1 170681570 6144063 complement(2656790..2657806) 1 NC_010498.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2657806 eutD 6144063 eutD Escherichia coli SMS-3-5 phosphotransacetylase YP_001744640.1 2656790 R 439855 CDS YP_001744641.1 170682304 6145755 complement(2657803..2658606) 1 NC_010498.1 identified by match to protein family HMM PF01923; ethanolamine utilization cobalamin adenosyltransferase 2658606 eutT 6145755 eutT Escherichia coli SMS-3-5 ethanolamine utilization cobalamin adenosyltransferase YP_001744641.1 2657803 R 439855 CDS YP_001744642.1 170682973 6146503 complement(2658603..2659304) 1 NC_010498.1 identified by match to protein family HMM PF05899; match to protein family HMM PF06249; ethanolamine utilization protein EutQ 2659304 6146503 EcSMS35_2606 Escherichia coli SMS-3-5 ethanolamine utilization protein EutQ YP_001744642.1 2658603 R 439855 CDS YP_001744643.1 170683599 6147188 complement(2659279..2659758) 1 NC_010498.1 identified by match to protein family HMM TIGR02528; ethanolamine utilization protein, EutP 2659758 eutP 6147188 eutP Escherichia coli SMS-3-5 ethanolamine utilization protein, EutP YP_001744643.1 2659279 R 439855 CDS YP_001744644.1 170684283 6142889 complement(2659771..2660106) 1 NC_010498.1 identified by match to protein family HMM PF00936; ethanolamine utilization protein EutS 2660106 6142889 EcSMS35_2608 Escherichia coli SMS-3-5 ethanolamine utilization protein EutS YP_001744644.1 2659771 R 439855 CDS YP_001744645.1 170679751 6143585 complement(2660399..2662678) 1 NC_010498.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2662678 maeB 6143585 maeB Escherichia coli SMS-3-5 malic enzyme YP_001744645.1 2660399 R 439855 CDS YP_001744646.1 170683372 6143909 2662967..2663917 1 NC_010498.1 identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874; transaldolase A 2663917 tal1 6143909 tal1 Escherichia coli SMS-3-5 transaldolase A YP_001744646.1 2662967 D 439855 CDS YP_001744647.1 170679675 6142658 2663937..2665940 1 NC_010498.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2665940 tktB 6142658 tktB Escherichia coli SMS-3-5 transketolase YP_001744647.1 2663937 D 439855 CDS YP_001744648.1 170680736 6143833 complement(2666043..2667086) 1 NC_010498.1 identified by match to protein family HMM PF06674; hypothetical protein 2667086 6143833 EcSMS35_2612 Escherichia coli SMS-3-5 hypothetical protein YP_001744648.1 2666043 R 439855 CDS YP_001744649.1 170680976 6144911 complement(2667212..2667787) 1 NC_010498.1 identified by match to protein family HMM PF00293; match to protein family HMM TIGR00052; NUDIX family hydrolase 2667787 6144911 EcSMS35_2613 Escherichia coli SMS-3-5 NUDIX family hydrolase YP_001744649.1 2667212 R 439855 CDS YP_001744650.1 170681460 6145157 complement(2667855..2669834) 1 NC_010498.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 2669834 aegA1 6145157 aegA1 Escherichia coli SMS-3-5 putative oxidoreductase Fe-S binding subunit YP_001744650.1 2667855 R 439855 CDS YP_001744651.1 170682253 6145645 2670040..2671740 1 NC_010498.1 identified by similarity to SP:P27896; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensor protein NarQ 2671740 narQ 6145645 narQ Escherichia coli SMS-3-5 nitrate/nitrite sensor protein NarQ YP_001744651.1 2670040 D 439855 CDS YP_001744652.1 170683475 6146452 2671904..2675017 1 NC_010498.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; aminoglycoside/multidrug efflux system 2675017 acrD 6146452 acrD Escherichia coli SMS-3-5 aminoglycoside/multidrug efflux system YP_001744652.1 2671904 D 439855 CDS YP_001744653.1 170683223 6142764 2675556..2675912 1 NC_010498.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein 2675912 6142764 EcSMS35_2617 Escherichia coli SMS-3-5 hypothetical protein YP_001744653.1 2675556 D 439855 CDS YP_001744654.1 170683901 6147444 2675916..2677043 1 NC_010498.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2677043 dapE 6147444 dapE Escherichia coli SMS-3-5 succinyl-diaminopimelate desuccinylase YP_001744654.1 2675916 D 439855 CDS YP_001744655.1 170680274 6143197 2677071..2677271 1 NC_010498.1 hypothetical protein 2677271 6143197 EcSMS35_2619 Escherichia coli SMS-3-5 hypothetical protein YP_001744655.1 2677071 D 439855 CDS YP_001744656.1 170683913 6144441 complement(2677352..2678050) 1 NC_010498.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2678050 6144441 EcSMS35_2620 Escherichia coli SMS-3-5 esterase YpfH YP_001744656.1 2677352 R 439855 CDS YP_001744657.1 170683380 6143209 complement(2678124..2680139) 1 NC_010498.1 identified by match to protein family HMM PF05127; hypothetical protein 2680139 6143209 EcSMS35_2621 Escherichia coli SMS-3-5 hypothetical protein YP_001744657.1 2678124 R 439855 CDS YP_001744658.1 170683921 6142666 complement(2680154..2681017) 1 NC_010498.1 identified by match to protein family HMM PF04228; hypothetical protein 2681017 6142666 EcSMS35_2622 Escherichia coli SMS-3-5 hypothetical protein YP_001744658.1 2680154 R 439855 CDS YP_001744659.1 170683399 6143217 complement(2681185..2681898) 1 NC_010498.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2681898 purC 6143217 purC Escherichia coli SMS-3-5 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_001744659.1 2681185 R 439855 CDS YP_001744660.1 170682569 6142685 complement(2682111..2683145) 1 NC_010498.1 identified by match to protein family HMM PF06804; lipoprotein 2683145 6142685 EcSMS35_2624 Escherichia coli SMS-3-5 lipoprotein YP_001744660.1 2682111 R 439855 CDS YP_001744661.1 170682058 6146774 complement(2683162..2684040) 1 NC_010498.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2684040 dapA 6146774 dapA Escherichia coli SMS-3-5 dihydrodipicolinate synthase YP_001744661.1 2683162 R 439855 CDS YP_001744662.1 170680018 6146255 2684186..2684758 1 NC_010498.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2684758 gcvR 6146255 gcvR Escherichia coli SMS-3-5 glycine cleavage system transcriptional repressor YP_001744662.1 2684186 D 439855 CDS YP_001744663.1 170681618 6144181 2684758..2685228 1 NC_010498.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2685228 bcp 6144181 bcp Escherichia coli SMS-3-5 thioredoxin-dependent thiol peroxidase YP_001744663.1 2684758 D 439855 CDS YP_001744664.1 170683521 6145803 2685481..2686098 1 NC_010498.1 identified by match to protein family HMM PF00037; hydrogenase-4 component A 2686098 hyfA 6145803 hyfA Escherichia coli SMS-3-5 hydrogenase-4 component A YP_001744664.1 2685481 D 439855 CDS YP_001744665.1 170680316 6142811 2686098..2688116 1 NC_010498.1 identified by similarity to SP:P23482; match to protein family HMM PF00361; hydrogenase 4 subunit B 2688116 hyfB 6142811 hyfB Escherichia coli SMS-3-5 hydrogenase 4 subunit B YP_001744665.1 2686098 D 439855 CDS YP_001744666.1 170683202 6144484 2688127..2689074 1 NC_010498.1 identified by match to protein family HMM PF00146; hydrogenase-4 component C 2689074 hyfC 6144484 hyfC Escherichia coli SMS-3-5 hydrogenase-4 component C YP_001744666.1 2688127 D 439855 CDS YP_001744667.1 170682661 6147422 2689091..2690530 1 NC_010498.1 identified by similarity to SP:P77416; match to protein family HMM PF00361; hydrogenase 4 subunit D 2690530 hyfD 6147422 hyfD Escherichia coli SMS-3-5 hydrogenase 4 subunit D YP_001744667.1 2689091 D 439855 CDS YP_001744668.1 170683797 6146868 2690542..2691192 1 NC_010498.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2691192 hyfE 6146868 hyfE Escherichia coli SMS-3-5 hydrogenase 4 membrane subunit YP_001744668.1 2690542 D 439855 CDS YP_001744669.1 170683161 6143090 2691197..2692777 1 NC_010498.1 identified by match to protein family HMM PF00361; hydrogenase 4 subunit F 2692777 6143090 EcSMS35_2633 Escherichia coli SMS-3-5 hydrogenase 4 subunit F YP_001744669.1 2691197 D 439855 CDS YP_001744670.1 170680711 6147381 2692767..2694482 1 NC_010498.1 identified by match to protein family HMM PF00329; match to protein family HMM PF00346; hydrogenase-4, G subunit 2694482 6147381 EcSMS35_2634 Escherichia coli SMS-3-5 hydrogenase-4, G subunit YP_001744670.1 2692767 D 439855 CDS YP_001744671.1 170680047 6144886 2694492..2695037 1 NC_010498.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2695037 6144886 EcSMS35_2635 Escherichia coli SMS-3-5 hydrogenase 4 subunit H YP_001744671.1 2694492 D 439855 CDS YP_001744672.1 170682690 6144210 2695034..2695792 1 NC_010498.1 identified by match to protein family HMM PF01058; hydrogenase-4, I subunit 2695792 6144210 EcSMS35_2636 Escherichia coli SMS-3-5 hydrogenase-4, I subunit YP_001744672.1 2695034 D 439855 CDS YP_001744673.1 170681693 6146898 2695785..2696198 1 NC_010498.1 identified by match to protein family HMM PF07450; formate hydrogenlyase maturation protein HycH 2696198 6146898 EcSMS35_2637 Escherichia coli SMS-3-5 formate hydrogenlyase maturation protein HycH YP_001744673.1 2695785 D 439855 CDS YP_001744674.1 170683782 6145879 2696228..2698240 1 NC_010498.1 identified by similarity to SP:P71229; match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; hydrogenase-4 transcriptional regulator 2698240 hyfR 6145879 hyfR Escherichia coli SMS-3-5 hydrogenase-4 transcriptional regulator YP_001744674.1 2696228 D 439855 CDS YP_001744675.1 170683125 6143074 2698262..2699110 1 NC_010498.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon; putative formate transporter 2699110 focB 6143074 focB Escherichia coli SMS-3-5 putative formate transporter YP_001744675.1 2698262 D 439855 CDS YP_001744676.1 170684284 6147344 complement(2699147..2700208) 1 NC_010498.1 identified by match to protein family HMM PF01594; PerM family permease 2700208 6147344 EcSMS35_2640 Escherichia coli SMS-3-5 PerM family permease YP_001744676.1 2699147 R 439855 CDS YP_001744677.1 170680376 6143586 2700421..2701884 1 NC_010498.1 identified by match to protein family HMM PF01435; M48 family peptidase 2701884 6143586 EcSMS35_2641 Escherichia coli SMS-3-5 M48 family peptidase YP_001744677.1 2700421 D 439855 CDS YP_001744678.1 170683437 6144544 2701905..2702264 1 NC_010498.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 2702264 arsC1 6144544 arsC1 Escherichia coli SMS-3-5 arsenate reductase YP_001744678.1 2701905 D 439855 CDS YP_001744679.1 170684093 6142724 complement(2702370..2703116) 1 NC_010498.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2703116 hda 6142724 hda Escherichia coli SMS-3-5 DNA replication initiation factor YP_001744679.1 2702370 R 439855 CDS YP_001744680.1 170682412 6143393 complement(2703166..2704455) 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil transporter 2704455 uraA 6143393 uraA Escherichia coli SMS-3-5 uracil transporter YP_001744680.1 2703166 R 439855 CDS YP_001744681.1 170683104 6146611 complement(2704541..2705167) 1 NC_010498.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2705167 upp 6146611 upp Escherichia coli SMS-3-5 uracil phosphoribosyltransferase YP_001744681.1 2704541 R 439855 CDS YP_001744682.1 170680261 6147323 2705144..2705278 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2705278 6147323 EcSMS35_2646 Escherichia coli SMS-3-5 hypothetical protein YP_001744682.1 2705144 D 439855 CDS YP_001744683.1 170680721 6144428 2705492..2706529 1 NC_010498.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2706529 purM 6144428 purM Escherichia coli SMS-3-5 phosphoribosylaminoimidazole synthetase YP_001744683.1 2705492 D 439855 CDS YP_001744684.1 170683963 6144896 2706529..2707167 1 NC_010498.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2707167 purN 6144896 purN Escherichia coli SMS-3-5 phosphoribosylglycinamide formyltransferase YP_001744684.1 2706529 D 439855 CDS YP_001744685.1 170679676 6143260 2707339..2709405 1 NC_010498.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2709405 ppk 6143260 ppk Escherichia coli SMS-3-5 polyphosphate kinase YP_001744685.1 2707339 D 439855 CDS YP_001744686.1 170682766 6143834 2709410..2710951 1 NC_010498.1 identified by match to protein family HMM PF02541; exopolyphosphatase 2710951 ppx 6143834 ppx Escherichia coli SMS-3-5 exopolyphosphatase YP_001744686.1 2709410 D 439855 CDS YP_001744687.1 170682075 6146975 complement(2710990..2713233) 1 NC_010498.1 yfgF; identified by match to protein family HMM PF00563; match to protein family HMM PF05231; putative cytochrome C-type biogenesis protein 2713233 6146975 EcSMS35_2651 Escherichia coli SMS-3-5 putative cytochrome C-type biogenesis protein YP_001744687.1 2710990 R 439855 CDS YP_001744688.1 170680862 6146272 complement(2713415..2713567) 1 NC_010498.1 hypothetical protein 2713567 6146272 EcSMS35_2652 Escherichia coli SMS-3-5 hypothetical protein YP_001744688.1 2713415 R 439855 CDS YP_001744689.1 170681357 6145039 2713585..2713776 1 NC_010498.1 hypothetical protein 2713776 6145039 EcSMS35_2653 Escherichia coli SMS-3-5 hypothetical protein YP_001744689.1 2713585 D 439855 CDS YP_001744690.1 170684016 6145541 2714090..2714605 1 NC_010498.1 identified by match to protein family HMM PF05433; surface antigen family protein 2714605 6145541 EcSMS35_2654 Escherichia coli SMS-3-5 surface antigen family protein YP_001744690.1 2714090 D 439855 CDS YP_001744691.1 170682478 6143315 2714621..2715160 1 NC_010498.1 hypothetical protein 2715160 6143315 EcSMS35_2655 Escherichia coli SMS-3-5 hypothetical protein YP_001744691.1 2714621 D 439855 CDS YP_001744692.1 170683481 6146677 complement(2715255..2716832) 1 NC_010498.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2716832 guaA 6146677 guaA Escherichia coli SMS-3-5 GMP synthase YP_001744692.1 2715255 R 439855 CDS YP_001744693.1 170684009 6142770 complement(2716901..2718436) 1 NC_010498.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2718436 guaB 6142770 guaB Escherichia coli SMS-3-5 inosine 5'-monophosphate dehydrogenase YP_001744693.1 2716901 R 439855 CDS YP_001744694.1 170679853 6143308 2718529..2719896 1 NC_010498.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2719896 xseA 6143308 xseA Escherichia coli SMS-3-5 exodeoxyribonuclease VII large subunit YP_001744694.1 2718529 D 439855 CDS YP_001744695.1 170680333 6144015 complement(2719950..2728025) 1 NC_010498.1 identified by match to protein family HMM PF05688; match to protein family HMM PF05689; RatA-like protein 2728025 6144015 EcSMS35_2659 Escherichia coli SMS-3-5 RatA-like protein YP_001744695.1 2719950 R 439855 CDS YP_001744696.1 170680922 6144501 complement(2728135..2729127) 1 NC_010498.1 putative adhesin 2729127 6144501 EcSMS35_2660 Escherichia coli SMS-3-5 putative adhesin YP_001744696.1 2728135 R 439855 CDS YP_001744697.1 170681535 6145103 complement(2729183..2731357) 1 NC_010498.1 putative adhesin 2731357 6145103 EcSMS35_2661 Escherichia coli SMS-3-5 putative adhesin YP_001744697.1 2729183 R 439855 CDS YP_001744698.1 170680650 6145720 complement(2731567..2731782) 1 NC_010498.1 identified by similarity to GB:AAP83330.1; match to protein family HMM PF07191; hypothetical protein 2731782 6145720 EcSMS35_2662 Escherichia coli SMS-3-5 hypothetical protein YP_001744698.1 2731567 R 439855 CDS YP_001744699.1 170681267 6144825 complement(2731845..2733317) 1 NC_010498.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2733317 engA 6144825 engA Escherichia coli SMS-3-5 GTP-binding protein EngA YP_001744699.1 2731845 R 439855 CDS YP_001744700.1 170681614 6145451 complement(2733435..2734613) 1 NC_010498.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2734613 6145451 EcSMS35_2664 Escherichia coli SMS-3-5 outer membrane protein assembly complex subunit YfgL YP_001744700.1 2733435 R 439855 CDS YP_001744701.1 170682168 6145799 complement(2734624..2735244) 1 NC_010498.1 hypothetical protein 2735244 6145799 EcSMS35_2665 Escherichia coli SMS-3-5 hypothetical protein YP_001744701.1 2734624 R 439855 CDS YP_001744702.1 170682103 6146367 complement(2735262..2736536) 1 NC_010498.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2736536 hisS 6146367 hisS Escherichia coli SMS-3-5 histidyl-tRNA synthetase YP_001744702.1 2735262 R 439855 CDS YP_001744703.1 170682819 6146301 complement(2736647..2737765) 1 NC_010498.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2737765 ispG 6146301 ispG Escherichia coli SMS-3-5 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001744703.1 2736647 R 439855 CDS YP_001744704.1 170683159 6147030 complement(2737792..2738802) 1 NC_010498.1 identified by match to protein family HMM PF01381; cytoskeletal protein RodZ 2738802 6147030 EcSMS35_2668 Escherichia coli SMS-3-5 cytoskeletal protein RodZ YP_001744704.1 2737792 R 439855 CDS YP_001744705.1 170683806 6147379 complement(2739087..2740241) 1 NC_010498.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2740241 6147379 EcSMS35_2669 Escherichia coli SMS-3-5 ribosomal RNA large subunit methyltransferase N YP_001744705.1 2739087 R 439855 CDS YP_001744706.1 170680359 6143100 complement(2740391..2740822) 1 NC_010498.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2740822 ndk 6143100 ndk Escherichia coli SMS-3-5 nucleoside diphosphate kinase YP_001744706.1 2740391 R 439855 CDS YP_001744707.1 170683227 6144527 complement(2740971..2743283) 1 NC_010498.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2743283 pbpC 6144527 pbpC Escherichia coli SMS-3-5 penicillin-binding protein 1C YP_001744707.1 2740971 R 439855 CDS YP_001744708.1 170682175 6147448 complement(2743284..2748242) 1 NC_010498.1 identified by match to protein family HMM PF01835; match to protein family HMM PF07703; alpha-2-macroglobulin domain-containing protein 2748242 6147448 EcSMS35_2672 Escherichia coli SMS-3-5 alpha-2-macroglobulin domain-containing protein YP_001744708.1 2743284 R 439855 CDS YP_001744709.1 170682726 6146374 2748449..2749294 1 NC_010498.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2749294 sseA 6146374 sseA Escherichia coli SMS-3-5 3-mercaptopyruvate sulfurtransferase YP_001744709.1 2748449 D 439855 CDS YP_001744710.1 170682971 6146934 complement(2749791..2750567) 1 NC_010498.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2750567 sseB 6146934 sseB Escherichia coli SMS-3-5 enhanced serine sensitivity protein SseB YP_001744710.1 2749791 R 439855 CDS YP_001744711.1 170681265 6147186 complement(2750709..2751992) 1 NC_010498.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 2751992 pepB 6147186 pepB Escherichia coli SMS-3-5 aminopeptidase B YP_001744711.1 2750709 R 439855 CDS YP_001744712.1 170682979 6145449 complement(2752051..2752251) 1 NC_010498.1 identified by match to protein family HMM PF04384; match to protein family HMM TIGR03412; hypothetical protein 2752251 iscX 6145449 iscX Escherichia coli SMS-3-5 hypothetical protein YP_001744712.1 2752051 R 439855 CDS YP_001744713.1 170681073 6147194 complement(2752263..2752598) 1 NC_010498.1 identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007; ferredoxin, 2Fe-2S type, ISC system 2752598 fdx 6147194 fdx Escherichia coli SMS-3-5 ferredoxin, 2Fe-2S type, ISC system YP_001744713.1 2752263 R 439855 CDS YP_001744714.1 170680961 6145255 complement(2752600..2754450) 1 NC_010498.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2754450 hscA 6145255 hscA Escherichia coli SMS-3-5 chaperone protein HscA YP_001744714.1 2752600 R 439855 CDS YP_001744715.1 170681471 6145142 complement(2754467..2754982) 1 NC_010498.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2754982 hscB 6145142 hscB Escherichia coli SMS-3-5 co-chaperone HscB YP_001744715.1 2754467 R 439855 CDS YP_001744716.1 170679589 6145656 complement(2754990..2755106) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2755106 6145656 EcSMS35_2680 Escherichia coli SMS-3-5 hypothetical protein YP_001744716.1 2754990 R 439855 CDS YP_001744717.1 170681489 6143746 complement(2755078..2755401) 1 NC_010498.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2755401 iscA 6143746 iscA Escherichia coli SMS-3-5 iron-sulfur cluster assembly protein YP_001744717.1 2755078 R 439855 CDS YP_001744718.1 170683007 6145674 complement(2755418..2755804) 1 NC_010498.1 identified by match to protein family HMM PF01592; match to protein family HMM TIGR01999; scaffold protein 2755804 iscU 6145674 iscU Escherichia coli SMS-3-5 scaffold protein YP_001744718.1 2755418 R 439855 CDS YP_001744719.1 170682464 6147223 complement(2755832..2757046) 1 NC_010498.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2757046 iscS 6147223 iscS Escherichia coli SMS-3-5 cysteine desulfurase YP_001744719.1 2755832 R 439855 CDS YP_001744720.1 170684046 6146663 complement(2757158..2757646) 1 NC_010498.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2757646 iscR 6146663 iscR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator IscR YP_001744720.1 2757158 R 439855 CDS YP_001744721.1 170683683 6143345 complement(2757917..2758657) 1 NC_010498.1 identified by match to protein family HMM PF00588; match to protein family HMM TIGR00050; RNA methyltransferase 2758657 6143345 EcSMS35_2685 Escherichia coli SMS-3-5 RNA methyltransferase YP_001744721.1 2757917 R 439855 CDS YP_001744722.1 170682874 6142975 2758776..2759579 1 NC_010498.1 identified by match to protein family HMM PF00459; inositol monophosphatase 2759579 suhB 6142975 suhB Escherichia coli SMS-3-5 inositol monophosphatase YP_001744722.1 2758776 D 439855 CDS YP_001744723.1 170682318 6147087 2759724..2760578 1 NC_010498.1 hypothetical protein 2760578 6147087 EcSMS35_2687 Escherichia coli SMS-3-5 hypothetical protein YP_001744723.1 2759724 D 439855 CDS YP_001744724.1 170683567 6146517 2760769..2762049 1 NC_010498.1 identified by match to protein family HMM PF00874; stationary phase inducible protein CsiE 2762049 csiE 6146517 csiE Escherichia coli SMS-3-5 stationary phase inducible protein CsiE YP_001744724.1 2760769 D 439855 CDS YP_001744725.1 170684196 6142858 complement(2762041..2763180) 1 NC_010498.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 2763180 hcaT 6142858 hcaT Escherichia coli SMS-3-5 putative 3-phenylpropionic acid transporter YP_001744725.1 2762041 R 439855 CDS YP_001744726.1 170681286 6143497 complement(2763340..2764233) 1 NC_010498.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2764233 hcaR 6143497 hcaR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator HcaR YP_001744726.1 2763340 R 439855 CDS YP_001744727.1 170680180 6145470 2764366..2765727 1 NC_010498.1 identified by match to protein family HMM PF00355; match to protein family HMM PF00848; 3-phenylpropionate dioxygenase alpha subunit 2765727 hcaE 6145470 hcaE Escherichia coli SMS-3-5 3-phenylpropionate dioxygenase alpha subunit YP_001744727.1 2764366 D 439855 CDS YP_001744728.1 170679701 6144346 2765724..2766242 1 NC_010498.1 identified by match to protein family HMM PF00866; 3-phenylpropionate dioxygenase subunit beta 2766242 hcaF 6144346 hcaF Escherichia coli SMS-3-5 3-phenylpropionate dioxygenase subunit beta YP_001744728.1 2765724 D 439855 CDS YP_001744729.1 170683920 6143859 2766242..2766562 1 NC_010498.1 identified by match to protein family HMM PF00355; 3-phenylpropionate dioxygenase ferredoxin subunit 2766562 hcaC 6143859 hcaC Escherichia coli SMS-3-5 3-phenylpropionate dioxygenase ferredoxin subunit YP_001744729.1 2766242 D 439855 CDS YP_001744730.1 170683398 6143216 2766559..2767371 1 NC_010498.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2767371 hcaB 6143216 hcaB Escherichia coli SMS-3-5 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_001744730.1 2766559 D 439855 CDS YP_001744731.1 170683500 6142684 2767381..2768583 1 NC_010498.1 identified by match to protein family HMM PF00070; match to protein family HMM PF07992; phenylpropionate dioxygenase ferredoxin reductase subunit 2768583 hcaD 6142684 hcaD Escherichia coli SMS-3-5 phenylpropionate dioxygenase ferredoxin reductase subunit YP_001744731.1 2767381 D 439855 CDS YP_001744732.1 170683033 6142789 2768680..2769102 1 NC_010498.1 identified by match to protein family HMM PF07681; putative inner membrane protein YphA 2769102 6142789 EcSMS35_2696 Escherichia coli SMS-3-5 putative inner membrane protein YphA YP_001744732.1 2768680 D 439855 CDS YP_001744733.1 170682346 6147249 complement(2769150..2770022) 1 NC_010498.1 identified by match to protein family HMM PF01263; aldose 1-epimerase family protein 2770022 6147249 EcSMS35_2697 Escherichia coli SMS-3-5 aldose 1-epimerase family protein YP_001744733.1 2769150 R 439855 CDS YP_001744734.1 170681398 6146545 complement(2770034..2771128) 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 2771128 6146545 EcSMS35_2698 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001744734.1 2770034 R 439855 CDS YP_001744735.1 170680743 6145582 complement(2771161..2772159) 1 NC_010498.1 identified by match to protein family HMM PF02653; putative sugar ABC transporter permease 2772159 6145582 EcSMS35_2699 Escherichia coli SMS-3-5 putative sugar ABC transporter permease YP_001744735.1 2771161 R 439855 CDS YP_001744736.1 170683588 6144918 complement(2772184..2773695) 1 NC_010498.1 identified by match to protein family HMM PF00005; putative sugar ABC transporter ATP-binding protein 2773695 6144918 EcSMS35_2700 Escherichia coli SMS-3-5 putative sugar ABC transporter ATP-binding protein YP_001744736.1 2772184 R 439855 CDS YP_001744737.1 170682923 6142879 complement(2773718..2774701) 1 NC_010498.1 identified by match to protein family HMM PF00532; putative sugar ABC transporter periplasmic sugar-binding protein 2774701 6142879 EcSMS35_2701 Escherichia coli SMS-3-5 putative sugar ABC transporter periplasmic sugar-binding protein YP_001744737.1 2773718 R 439855 CDS YP_001744738.1 170682243 6147137 complement(2774798..2778079) 1 NC_010498.1 identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR repeat-containing protein 2778079 6147137 EcSMS35_2702 Escherichia coli SMS-3-5 TPR repeat-containing protein YP_001744738.1 2774798 R 439855 CDS YP_001744739.1 170681604 6146442 2778197..2779390 1 NC_010498.1 identified by match to protein family HMM PF00480; ROK family protein 2779390 6146442 EcSMS35_2703 Escherichia coli SMS-3-5 ROK family protein YP_001744739.1 2778197 D 439855 CDS YP_001744740.1 170680929 6145789 complement(2779454..2780707) 1 NC_010498.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2780707 glyA 6145789 glyA Escherichia coli SMS-3-5 serine hydroxymethyltransferase YP_001744740.1 2779454 R 439855 CDS YP_001744741.1 170680268 6145110 2781035..2782225 1 NC_010498.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2782225 hmp 6145110 hmp Escherichia coli SMS-3-5 nitric oxide dioxygenase YP_001744741.1 2781035 D 439855 CDS YP_001744742.1 170679611 6144435 complement(2782270..2782608) 1 NC_010498.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2782608 glnB 6144435 glnB Escherichia coli SMS-3-5 nitrogen regulatory protein P-II 1 YP_001744742.1 2782270 R 439855 CDS YP_001744743.1 170681075 6143768 complement(2782669..2784003) 1 NC_010498.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728; sigma-54 dependent response regulator 2784003 6143768 EcSMS35_2707 Escherichia coli SMS-3-5 sigma-54 dependent response regulator YP_001744743.1 2782669 R 439855 CDS YP_001744744.1 170680612 6145257 complement(2783993..2784706) 1 NC_010498.1 hypothetical protein 2784706 6145257 EcSMS35_2708 Escherichia coli SMS-3-5 hypothetical protein YP_001744744.1 2783993 R 439855 CDS YP_001744745.1 170680109 6144786 complement(2784871..2786298) 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase 2786298 6144786 EcSMS35_2709 Escherichia coli SMS-3-5 sensor histidine kinase YP_001744745.1 2784871 R 439855 CDS YP_001744746.1 170682234 6144273 complement(2786875..2790762) 1 NC_010498.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2790762 purL 6144273 purL Escherichia coli SMS-3-5 phosphoribosylformylglycinamidine synthase YP_001744746.1 2786875 R 439855 CDS YP_001744747.1 170681428 6146433 2791022..2792578 1 NC_010498.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2792578 6146433 EcSMS35_2712 Escherichia coli SMS-3-5 putative transglycosylase YP_001744747.1 2791022 D 439855 CDS YP_001744748.1 170682913 6145612 complement(2792575..2793078) 1 NC_010498.1 identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase 2793078 tadA 6145612 tadA Escherichia coli SMS-3-5 tRNA-specific adenosine deaminase YP_001744748.1 2792575 R 439855 CDS YP_001744749.1 170679764 6147127 complement(2793136..2793771) 1 NC_010498.1 identified by match to protein family HMM TIGR01545; hypothetical protein 2793771 yhfB 6147127 yhfB Escherichia coli SMS-3-5 hypothetical protein YP_001744749.1 2793136 R 439855 CDS YP_001744750.1 170680195 6143923 2793980..2794828 1 NC_010498.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418; putative DNA-binding transcriptional regulator 2794828 6143923 EcSMS35_2714 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001744750.1 2793980 D 439855 CDS YP_001744751.1 170683213 6144361 2794860..2795144 1 NC_010498.1 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein 2795144 6144361 EcSMS35_2715 Escherichia coli SMS-3-5 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein YP_001744751.1 2794860 D 439855 CDS YP_001744752.1 170684119 6147434 complement(2795839..2796219) 1 NC_010498.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2796219 acpS 6147434 acpS Escherichia coli SMS-3-5 4'-phosphopantetheinyl transferase YP_001744752.1 2795839 R 439855 CDS YP_001744753.1 170682415 6143419 complement(2796219..2796950) 1 NC_010498.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2796950 pdxJ 6143419 pdxJ Escherichia coli SMS-3-5 pyridoxine 5'-phosphate synthase YP_001744753.1 2796219 R 439855 CDS YP_001744754.1 170681019 6146614 complement(2796962..2797690) 1 NC_010498.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2797690 recO 6146614 recO Escherichia coli SMS-3-5 DNA repair protein RecO YP_001744754.1 2796962 R 439855 CDS YP_001744755.1 170681506 6145200 complement(2797702..2798607) 1 NC_010498.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2798607 era 6145200 era Escherichia coli SMS-3-5 GTP-binding protein Era YP_001744755.1 2797702 R 439855 CDS YP_001744756.1 170680897 6145691 complement(2798604..2799284) 1 NC_010498.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2799284 rnc 6145691 rnc Escherichia coli SMS-3-5 ribonuclease III YP_001744756.1 2798604 R 439855 CDS YP_001744757.1 170680067 6145076 complement(2799557..2800531) 1 NC_010498.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2800531 lepB 6145076 lepB Escherichia coli SMS-3-5 signal peptidase I YP_001744757.1 2799557 R 439855 CDS YP_001744758.1 170679646 6144231 complement(2800547..2802346) 1 NC_010498.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2802346 lepA 6144231 lepA Escherichia coli SMS-3-5 GTP-binding protein LepA YP_001744758.1 2800547 R 439855 CDS YP_001744759.1 170684237 6143803 complement(2802543..2803022) 1 NC_010498.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2803022 rseC 6143803 rseC Escherichia coli SMS-3-5 SoxR reducing system protein RseC YP_001744759.1 2802543 R 439855 CDS YP_001744760.1 170683551 6143538 complement(2803019..2803975) 1 NC_010498.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2803975 rseB 6143538 rseB Escherichia coli SMS-3-5 periplasmic negative regulator of sigmaE YP_001744760.1 2803019 R 439855 CDS YP_001744761.1 170682893 6142841 complement(2803975..2804625) 1 NC_010498.1 identified by match to protein family HMM PF03872; match to protein family HMM PF03873; anti-RNA polymerase sigma factor SigE 2804625 rseA 6142841 rseA Escherichia coli SMS-3-5 anti-RNA polymerase sigma factor SigE YP_001744761.1 2803975 R 439855 CDS YP_001744762.1 170682217 6147106 complement(2804658..2805233) 1 NC_010498.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2805233 rpoE 6147106 rpoE Escherichia coli SMS-3-5 RNA polymerase sigma factor RpoE YP_001744762.1 2804658 R 439855 CDS YP_001744763.1 170681372 6146416 2805641..2807263 1 NC_010498.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2807263 nadB 6146416 nadB Escherichia coli SMS-3-5 L-aspartate oxidase YP_001744763.1 2805641 D 439855 CDS YP_001744764.1 170679700 6145556 complement(2807248..2807985) 1 NC_010498.1 identified by match to protein family HMM PF05175; putative methyltransferase 2807985 6145556 EcSMS35_2727 Escherichia coli SMS-3-5 putative methyltransferase YP_001744764.1 2807248 R 439855 CDS YP_001744765.1 170684258 6143858 2808117..2809451 1 NC_010498.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2809451 srmB 6143858 srmB Escherichia coli SMS-3-5 ATP-dependent RNA helicase SrmB YP_001744765.1 2808117 D 439855 CDS YP_001744766.1 170683897 6143560 complement(2809484..2810365) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 2810365 6143560 EcSMS35_2730 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001744766.1 2809484 R 439855 CDS YP_001744767.1 170680022 6143193 2810468..2811055 1 NC_010498.1 identified by match to protein family HMM PF01810; neutral amino-acid efflux protein 2811055 6143193 EcSMS35_2731 Escherichia coli SMS-3-5 neutral amino-acid efflux protein YP_001744767.1 2810468 D 439855 CDS YP_001744768.1 170680667 6144185 complement(2811110..2811493) 1 NC_010498.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2811493 grcA 6144185 grcA Escherichia coli SMS-3-5 autonomous glycyl radical cofactor GrcA YP_001744768.1 2811110 R 439855 CDS YP_001744769.1 170683958 6144842 2811798..2812487 1 NC_010498.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2812487 ung 6144842 ung Escherichia coli SMS-3-5 uracil-DNA glycosylase YP_001744769.1 2811798 D 439855 CDS YP_001744770.1 170683534 6143255 complement(2812535..2813572) 1 NC_010498.1 identified by match to protein family HMM PF00588; match to protein family HMM PF08032; putative methyltransferase 2813572 6143255 EcSMS35_2734 Escherichia coli SMS-3-5 putative methyltransferase YP_001744770.1 2812535 R 439855 CDS YP_001744771.1 170680235 6142824 2813779..2814198 1 NC_010498.1 identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 2 2814198 6142824 EcSMS35_2735 Escherichia coli SMS-3-5 thioredoxin 2 YP_001744771.1 2813779 D 439855 CDS YP_001744772.1 170679752 6144402 2814267..2814965 1 NC_010498.1 identified by match to protein family HMM PF03942; DTW domain-containing protein 2814965 6144402 EcSMS35_2736 Escherichia coli SMS-3-5 DTW domain-containing protein YP_001744772.1 2814267 D 439855 CDS YP_001744773.1 170681301 6143910 2814997..2817657 1 NC_010498.1 identified by match to protein family HMM PF00583; match to protein family HMM PF02629; CoA-binding domain/acetyltransferase domain-containing protein 2817657 6143910 EcSMS35_2737 Escherichia coli SMS-3-5 CoA-binding domain/acetyltransferase domain-containing protein YP_001744773.1 2814997 D 439855 CDS YP_001744774.1 170680781 6145485 2817771..2819126 1 NC_010498.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2819126 pssA 6145485 pssA Escherichia coli SMS-3-5 phosphatidylserine synthase YP_001744774.1 2817771 D 439855 CDS YP_001744775.1 170682656 6144956 2819223..2819495 1 NC_010498.1 hypothetical protein 2819495 6144956 EcSMS35_2740 Escherichia coli SMS-3-5 hypothetical protein YP_001744775.1 2819223 D 439855 CDS YP_001744776.1 170682366 6146863 complement(2819492..2820790) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; alpha-ketoglutarate transporter 2820790 kgtP 6146863 kgtP Escherichia coli SMS-3-5 alpha-ketoglutarate transporter YP_001744776.1 2819492 R 439855 CDS YP_001744777.1 170683980 6143716 complement(2826569..2829142) 1 NC_010498.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03346; protein disaggregation chaperone 2829142 clpB 6143716 clpB Escherichia coli SMS-3-5 protein disaggregation chaperone YP_001744777.1 2826569 R 439855 CDS YP_001744778.1 170684200 6143277 complement(2829272..2830003) 1 NC_010498.1 yfiH; identified by match to protein family HMM PF02578; match to protein family HMM TIGR00726; hypothetical protein 2830003 6143277 EcSMS35_2747 Escherichia coli SMS-3-5 hypothetical protein YP_001744778.1 2829272 R 439855 CDS YP_001744779.1 170683711 6143501 complement(2830000..2830980) 1 NC_010498.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2830980 rluD 6143501 rluD Escherichia coli SMS-3-5 23S rRNA pseudouridine synthase D YP_001744779.1 2830000 R 439855 CDS YP_001744780.1 170682905 6143003 2831115..2831852 1 NC_010498.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2831852 6143003 EcSMS35_2749 Escherichia coli SMS-3-5 outer membrane protein assembly complex subunit YfiO YP_001744780.1 2831115 D 439855 CDS YP_001744781.1 170682385 6147118 2832123..2832464 1 NC_010498.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2832464 6147118 EcSMS35_2750 Escherichia coli SMS-3-5 translation inhibitor protein RaiA YP_001744781.1 2832123 D 439855 CDS YP_001744782.1 170681627 6146584 2832714..2833874 1 NC_010498.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2833874 pheA 6146584 pheA Escherichia coli SMS-3-5 bifunctional chorismate mutase/prephenate dehydratase YP_001744782.1 2832714 D 439855 CDS YP_001744783.1 170679824 6145812 complement(2833917..2835038) 1 NC_010498.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2835038 tyrA 6145812 tyrA Escherichia coli SMS-3-5 bifunctional chorismate mutase/prephenate dehydrogenase YP_001744783.1 2833917 R 439855 CDS YP_001744784.1 170683035 6143986 complement(2835049..2836119) 1 NC_010498.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2836119 aroF 6143986 aroF Escherichia coli SMS-3-5 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001744784.1 2835049 R 439855 CDS YP_001744785.1 170680740 6147251 2836329..2836694 1 NC_010498.1 hypothetical protein 2836694 6147251 EcSMS35_2754 Escherichia coli SMS-3-5 hypothetical protein YP_001744785.1 2836329 D 439855 CDS YP_001744786.1 170682610 6144915 2836844..2837362 1 NC_010498.1 hypothetical protein 2837362 6144915 EcSMS35_2755 Escherichia coli SMS-3-5 hypothetical protein YP_001744786.1 2836844 D 439855 CDS YP_001744787.1 170683267 6146815 2837355..2838578 1 NC_010498.1 identified by match to protein family HMM PF00672; match to protein family HMM PF00990; match to protein family HMM TIGR00254; hypothetical protein 2838578 6146815 EcSMS35_2756 Escherichia coli SMS-3-5 hypothetical protein YP_001744787.1 2837355 D 439855 CDS YP_001744788.1 170681549 6147492 2838594..2839076 1 NC_010498.1 identified by match to protein family HMM PF00691; putative outer membrane lipoprotein 2839076 6147492 EcSMS35_2757 Escherichia coli SMS-3-5 putative outer membrane lipoprotein YP_001744788.1 2838594 D 439855 CDS YP_001744789.1 170682299 6145734 complement(2839153..2839500) 1 NC_010498.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2839500 rplS 6145734 rplS Escherichia coli SMS-3-5 50S ribosomal protein L19 YP_001744789.1 2839153 R 439855 CDS YP_001744790.1 170680491 6146498 complement(2839542..2840309) 1 NC_010498.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2840309 trmD 6146498 trmD Escherichia coli SMS-3-5 tRNA (guanine-N(1)-)-methyltransferase YP_001744790.1 2839542 R 439855 CDS YP_001744791.1 170681223 6144660 complement(2840340..2840891) 1 NC_010498.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2840891 rimM 6144660 rimM Escherichia coli SMS-3-5 16S rRNA-processing protein RimM YP_001744791.1 2840340 R 439855 CDS YP_001744792.1 170682475 6145407 complement(2840907..2841155) 1 NC_010498.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2841155 rpsP 6145407 rpsP Escherichia coli SMS-3-5 30S ribosomal protein S16 YP_001744792.1 2840907 R 439855 CDS YP_001744793.1 170684039 6146674 complement(2841292..2842653) 1 NC_010498.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2842653 ffh 6146674 ffh Escherichia coli SMS-3-5 signal recognition particle protein YP_001744793.1 2841292 R 439855 CDS YP_001744794.1 170681191 6143338 2842745..2843611 1 NC_010498.1 identified by match to protein family HMM PF01578; putative cytochrome C assembly protein 2843611 6143338 EcSMS35_2763 Escherichia coli SMS-3-5 putative cytochrome C assembly protein YP_001744794.1 2842745 D 439855 CDS YP_001744795.1 170681983 6145375 2843656..2844918 1 NC_010498.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hypothetical protein 2844918 6145375 EcSMS35_2764 Escherichia coli SMS-3-5 hypothetical protein YP_001744795.1 2843656 D 439855 CDS YP_001744796.1 170681847 6146179 2845042..2845647 1 NC_010498.1 hypothetical protein 2845647 6146179 EcSMS35_2765 Escherichia coli SMS-3-5 hypothetical protein YP_001744796.1 2845042 D 439855 CDS YP_001744797.1 170681212 6146040 complement(2845682..2846272) 1 NC_010498.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2846272 grpE 6146040 grpE Escherichia coli SMS-3-5 heat shock protein GrpE YP_001744797.1 2845682 R 439855 CDS YP_001744798.1 170679880 6145396 2846395..2847273 1 NC_010498.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2847273 ppnK 6145396 ppnK Escherichia coli SMS-3-5 inorganic polyphosphate/ATP-NAD kinase YP_001744798.1 2846395 D 439855 CDS YP_001744799.1 170683348 6144042 2847359..2849020 1 NC_010498.1 identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; recombination and repair protein 2849020 recN 6144042 recN Escherichia coli SMS-3-5 recombination and repair protein YP_001744799.1 2847359 D 439855 CDS YP_001744800.1 170680255 6142634 2849169..2849510 1 NC_010498.1 identified by match to protein family HMM PF04355; hypothetical protein 2849510 6142634 EcSMS35_2769 Escherichia coli SMS-3-5 hypothetical protein YP_001744800.1 2849169 D 439855 CDS YP_001744801.1 170681237 6144422 complement(2849572..2849862) 1 NC_010498.1 identified by match to protein family HMM PF03658; hypothetical protein 2849862 6144422 EcSMS35_2770 Escherichia coli SMS-3-5 hypothetical protein YP_001744801.1 2849572 R 439855 CDS YP_001744802.1 170683083 6145421 complement(2849852..2850328) 1 NC_010498.1 identified by match to protein family HMM PF03364; hypothetical protein 2850328 6145421 EcSMS35_2771 Escherichia coli SMS-3-5 hypothetical protein YP_001744802.1 2849852 R 439855 CDS YP_001744803.1 170679596 6147300 2850460..2850942 1 NC_010498.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2850942 smpB 6147300 smpB Escherichia coli SMS-3-5 SsrA-binding protein YP_001744803.1 2850460 D 439855 CDS YP_001744804.1 170679851 6143753 complement(2851680..2856377) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2856377 6143753 EcSMS35_2773 Escherichia coli SMS-3-5 hypothetical protein YP_001744804.1 2851680 R 439855 CDS YP_001744805.1 170681339 6144013 complement(2856313..2856432) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2856432 6144013 EcSMS35_2774 Escherichia coli SMS-3-5 hypothetical protein YP_001744805.1 2856313 R 439855 CDS YP_001744806.1 170680843 6145523 complement(2857184..2857933) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2857933 6145523 EcSMS35_2775 Escherichia coli SMS-3-5 hypothetical protein YP_001744806.1 2857184 R 439855 CDS YP_001744807.1 170681220 6143706 2860012..2862264 1 NC_010498.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02806; alpha amylase family protein 2862264 6143706 EcSMS35_2778 Escherichia coli SMS-3-5 alpha amylase family protein YP_001744807.1 2860012 D 439855 CDS YP_001744808.1 170682703 6145404 2862601..2863578 1 NC_010498.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2863578 6145404 EcSMS35_2779 Escherichia coli SMS-3-5 hypothetical protein YP_001744808.1 2862601 D 439855 CDS YP_001744809.1 170682247 6146911 2863598..2864866 1 NC_010498.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2864866 6146911 EcSMS35_2780 Escherichia coli SMS-3-5 hydroxyglutarate oxidase YP_001744809.1 2863598 D 439855 CDS YP_001744810.1 170679622 6146446 2864889..2866337 1 NC_010498.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2866337 gabD 6146446 gabD Escherichia coli SMS-3-5 succinate-semialdehyde dehydrogenase I YP_001744810.1 2864889 D 439855 CDS YP_001744811.1 170683877 6143779 2866351..2867631 1 NC_010498.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2867631 gabT2 6143779 gabT2 Escherichia coli SMS-3-5 4-aminobutyrate aminotransferase YP_001744811.1 2866351 D 439855 CDS YP_001744812.1 170680659 6143172 2867868..2869268 1 NC_010498.1 identified by match to protein family HMM PF00324; match to protein family HMM TIGR01773; gamma-aminobutyrate transporter 2869268 gabP 6143172 gabP Escherichia coli SMS-3-5 gamma-aminobutyrate transporter YP_001744812.1 2867868 D 439855 CDS YP_001744813.1 170683260 6144834 2869289..2869951 1 NC_010498.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2869951 csiR 6144834 csiR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator CsiR YP_001744813.1 2869289 D 439855 CDS YP_001744814.1 170681151 6147483 complement(2869952..2870401) 1 NC_010498.1 identified by match to protein family HMM PF01476; match to protein family HMM PF04972; LysM domain/BON superfamily protein 2870401 6147483 EcSMS35_2785 Escherichia coli SMS-3-5 LysM domain/BON superfamily protein YP_001744814.1 2869952 R 439855 CDS YP_001744815.1 170681644 6145334 complement(2870485..2870643) 1 NC_010498.1 identified by match to protein family HMM PF01679; hypothetical protein 2870643 6145334 EcSMS35_2786 Escherichia coli SMS-3-5 hypothetical protein YP_001744815.1 2870485 R 439855 CDS YP_001744816.1 170681146 6145830 2870826..2871125 1 NC_010498.1 identified by match to protein family HMM PF01022; ArsR family transcriptional regulator 2871125 6145830 EcSMS35_2787 Escherichia coli SMS-3-5 ArsR family transcriptional regulator YP_001744816.1 2870826 D 439855 CDS YP_001744817.1 170681672 6145329 2871135..2871659 1 NC_010498.1 putative inner membrane protein 2871659 6145329 EcSMS35_2788 Escherichia coli SMS-3-5 putative inner membrane protein YP_001744817.1 2871135 D 439855 CDS YP_001744818.1 170679595 6145858 complement(2871706..2872110) 1 NC_010498.1 identified by match to protein family HMM PF00816; DNA binding protein, nucleoid-associated 2872110 stpA 6145858 stpA Escherichia coli SMS-3-5 DNA binding protein, nucleoid-associated YP_001744818.1 2871706 R 439855 CDS YP_001744819.1 170680685 6143752 2872778..2873227 1 NC_010498.1 identified by match to protein family HMM PF06610; hypothetical protein 2873227 6143752 EcSMS35_2790 Escherichia coli SMS-3-5 hypothetical protein YP_001744819.1 2872778 D 439855 CDS YP_001744820.1 170683315 6144860 complement(2873264..2873608) 1 NC_010498.1 hypothetical protein 2873608 6144860 EcSMS35_2791 Escherichia coli SMS-3-5 hypothetical protein YP_001744820.1 2873264 R 439855 CDS YP_001744821.1 170683774 6142600 2873760..2874089 1 NC_010498.1 identified by match to protein family HMM PF05957; hypothetical protein 2874089 6142600 EcSMS35_2792 Escherichia coli SMS-3-5 hypothetical protein YP_001744821.1 2873760 D 439855 CDS YP_001744822.1 170681638 6143066 complement(2874146..2875480) 1 NC_010498.1 identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator 2875480 6143066 EcSMS35_2793 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001744822.1 2874146 R 439855 CDS YP_001744823.1 170681664 6145824 2875568..2875999 1 NC_010498.1 identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; carboxymuconolactone decarboxylase family protein 2875999 6145824 EcSMS35_2794 Escherichia coli SMS-3-5 carboxymuconolactone decarboxylase family protein YP_001744823.1 2875568 D 439855 CDS YP_001744824.1 170682324 6145850 2876208..2876453 1 NC_010498.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin-like protein 2876453 nrdH 6145850 nrdH Escherichia coli SMS-3-5 glutaredoxin-like protein YP_001744824.1 2876208 D 439855 CDS YP_001744825.1 170683274 6146523 2876450..2876860 1 NC_010498.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2876860 nrdI 6146523 nrdI Escherichia coli SMS-3-5 ribonucleotide reductase stimulatory protein YP_001744825.1 2876450 D 439855 CDS YP_001744826.1 170683654 6147500 2876833..2878977 1 NC_010498.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2878977 nrdE 6147500 nrdE Escherichia coli SMS-3-5 ribonucleotide-diphosphate reductase subunit alpha YP_001744826.1 2876833 D 439855 CDS YP_001744827.1 170684037 6142946 2878987..2879946 1 NC_010498.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2879946 nrdF 6142946 nrdF Escherichia coli SMS-3-5 ribonucleotide-diphosphate reductase subunit beta YP_001744827.1 2878987 D 439855 CDS YP_001744828.1 170679605 6143336 2880302..2881504 1 NC_010498.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2881504 proV 6143336 proV Escherichia coli SMS-3-5 glycine betaine transporter ATP-binding subunit YP_001744828.1 2880302 D 439855 CDS YP_001744829.1 170680258 6143762 2881497..2882561 1 NC_010498.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2882561 proW 6143762 proW Escherichia coli SMS-3-5 glycine betaine transporter membrane protein YP_001744829.1 2881497 D 439855 CDS YP_001744830.1 170681945 6144425 2882619..2883611 1 NC_010498.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2883611 proX 6144425 proX Escherichia coli SMS-3-5 glycine betaine transporter periplasmic subunit YP_001744830.1 2882619 D 439855 CDS YP_001744831.1 170682617 6146141 2883664..2883810 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2883810 6146141 EcSMS35_2802 Escherichia coli SMS-3-5 hypothetical protein YP_001744831.1 2883664 D 439855 CDS YP_001744832.1 170682932 6146823 2883803..2884987 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator family transporter 2884987 6146823 EcSMS35_2803 Escherichia coli SMS-3-5 major facilitator family transporter YP_001744832.1 2883803 D 439855 CDS YP_001744833.1 170680260 6147146 2885156..2885848 1 NC_010498.1 identified by match to protein family HMM PF03591; branched chain amino acid ABC transporter 2885848 6147146 EcSMS35_2804 Escherichia coli SMS-3-5 branched chain amino acid ABC transporter YP_001744833.1 2885156 D 439855 CDS YP_001744834.1 170682354 6144427 2885838..2886173 1 NC_010498.1 hypothetical protein 2886173 6144427 EcSMS35_2805 Escherichia coli SMS-3-5 hypothetical protein YP_001744834.1 2885838 D 439855 CDS YP_001744835.1 170681637 6146553 2886264..2886794 1 NC_010498.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2886794 mprA 6146553 mprA Escherichia coli SMS-3-5 transcriptional repressor MprA YP_001744835.1 2886264 D 439855 CDS YP_001744836.1 170682707 6145823 2886921..2888093 1 NC_010498.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR00998; multidrug resistance protein A 2888093 emrA 6145823 emrA Escherichia coli SMS-3-5 multidrug resistance protein A YP_001744836.1 2886921 D 439855 CDS YP_001744837.1 170682086 6146915 2888110..2889648 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; multidrug resistance protein B 2889648 emrB 6146915 emrB Escherichia coli SMS-3-5 multidrug resistance protein B YP_001744837.1 2888110 D 439855 CDS YP_001744838.1 170683741 6146283 complement(2889712..2890227) 1 NC_010498.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2890227 luxS 6146283 luxS Escherichia coli SMS-3-5 S-ribosylhomocysteinase YP_001744838.1 2889712 R 439855 CDS YP_001744839.1 170683222 6143033 complement(2890377..2891933) 1 NC_010498.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2891933 gshA 6143033 gshA Escherichia coli SMS-3-5 glutamate--cysteine ligase YP_001744839.1 2890377 R 439855 CDS YP_001744840.1 170681345 6147443 complement(2892006..2892434) 1 NC_010498.1 hypothetical protein 2892434 6147443 EcSMS35_2811 Escherichia coli SMS-3-5 hypothetical protein YP_001744840.1 2892006 R 439855 CDS YP_001744841.1 170680864 6145529 complement(2892431..2892997) 1 NC_010498.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2892997 6145529 EcSMS35_2812 Escherichia coli SMS-3-5 fructose-1-phosphatase YP_001744841.1 2892431 R 439855 CDS YP_001744842.1 170682990 6143707 complement(2894185..2894370) 1 NC_010498.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2894370 csrA 6143707 csrA Escherichia coli SMS-3-5 carbon storage regulator YP_001744842.1 2894185 R 439855 CDS YP_001744843.1 170681206 6147206 2894480..2894596 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2894596 6147206 EcSMS35_2819 Escherichia coli SMS-3-5 hypothetical protein YP_001744843.1 2894480 D 439855 CDS YP_001744844.1 170682603 6145390 complement(2894605..2897235) 1 NC_010498.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2897235 alaS 6145390 alaS Escherichia coli SMS-3-5 alanyl-tRNA synthetase YP_001744844.1 2894605 R 439855 CDS YP_001744845.1 170682194 6146808 complement(2897364..2897864) 1 NC_010498.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2897864 recX 6146808 recX Escherichia coli SMS-3-5 recombination regulator RecX YP_001744845.1 2897364 R 439855 CDS YP_001744846.1 170683219 6146393 complement(2897933..2898994) 1 NC_010498.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2898994 recA 6146393 recA Escherichia coli SMS-3-5 recombinase A YP_001744846.1 2897933 R 439855 CDS YP_001744847.1 170680608 6147440 complement(2899074..2899571) 1 NC_010498.1 identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199; competence damage-inducible protein A 2899571 6147440 EcSMS35_2823 Escherichia coli SMS-3-5 competence damage-inducible protein A YP_001744847.1 2899074 R 439855 CDS YP_001744848.1 170680146 6144782 complement(2899716..2900801) 1 NC_010498.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2900801 mltB 6144782 mltB Escherichia coli SMS-3-5 murein hydrolase B YP_001744848.1 2899716 R 439855 CDS YP_001744849.1 170681685 6144312 2901058..2901621 1 NC_010498.1 identified by match to protein family HMM PF03608; match to protein family HMM TIGR00821; PTS system, glucitol/sorbitol-specific, IIC component 2901621 srlA 6144312 srlA Escherichia coli SMS-3-5 PTS system, glucitol/sorbitol-specific, IIC component YP_001744849.1 2901058 D 439855 CDS YP_001744850.1 170681652 6145871 2901618..2902577 1 NC_010498.1 identified by match to protein family HMM PF03612; match to protein family HMM PF07663; match to protein family HMM TIGR00825; PTS system, glucitol/sorbitol-specific, IIB component 2902577 srlE 6145871 srlE Escherichia coli SMS-3-5 PTS system, glucitol/sorbitol-specific, IIB component YP_001744850.1 2901618 D 439855 CDS YP_001744851.1 170681142 6145838 2902588..2902959 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2902959 srlB 6145838 srlB Escherichia coli SMS-3-5 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_001744851.1 2902588 D 439855 CDS YP_001744852.1 170682204 6145325 2902963..2903742 1 NC_010498.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2903742 srlD 6145325 srlD Escherichia coli SMS-3-5 sorbitol-6-phosphate dehydrogenase YP_001744852.1 2902963 D 439855 CDS YP_001744853.1 170683226 6146403 2903848..2904207 1 NC_010498.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2904207 gutM 6146403 gutM Escherichia coli SMS-3-5 DNA-binding transcriptional activator GutM YP_001744853.1 2903848 D 439855 CDS YP_001744854.1 170680292 6147447 2904274..2905047 1 NC_010498.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2905047 srlR 6147447 srlR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor SrlR YP_001744854.1 2904274 D 439855 CDS YP_001744855.1 170680279 6144460 2905040..2906005 1 NC_010498.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2906005 gutQ 6144460 gutQ Escherichia coli SMS-3-5 D-arabinose 5-phosphate isomerase YP_001744855.1 2905040 D 439855 CDS YP_001744856.1 170679621 6144446 complement(2906002..2907516) 1 NC_010498.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator 2907516 norR 6144446 norR Escherichia coli SMS-3-5 anaerobic nitric oxide reductase transcription regulator YP_001744856.1 2906002 R 439855 CDS YP_001744857.1 170679642 6143778 2907703..2909142 1 NC_010498.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2909142 norV 6143778 norV Escherichia coli SMS-3-5 anaerobic nitric oxide reductase flavorubredoxin YP_001744857.1 2907703 D 439855 CDS YP_001744858.1 170681646 6143799 2909139..2910272 1 NC_010498.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2910272 norW 6143799 norW Escherichia coli SMS-3-5 nitric oxide reductase YP_001744858.1 2909139 D 439855 CDS YP_001744859.1 170680945 6145832 complement(2910351..2912639) 1 NC_010498.1 identified by similarity to SP:P30131; match to protein family HMM PF00708; match to protein family HMM PF01300; match to protein family HMM PF07503; match to protein family HMM TIGR00143; [NiFe] hydrogenase maturation protein HypF 2912639 hypF 6145832 hypF Escherichia coli SMS-3-5 [NiFe] hydrogenase maturation protein HypF YP_001744859.1 2910351 R 439855 CDS YP_001744860.1 170682992 6145126 complement(2912744..2913271) 1 NC_010498.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 2913271 6145126 EcSMS35_2836 Escherichia coli SMS-3-5 electron transport protein HydN YP_001744860.1 2912744 R 439855 CDS YP_001744861.1 170682276 6147208 complement(2913249..2913416) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2913416 6147208 EcSMS35_2837 Escherichia coli SMS-3-5 hypothetical protein YP_001744861.1 2913249 R 439855 CDS YP_001744862.1 170683113 6146475 complement(2913420..2914472) 1 NC_010498.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator AscG 2914472 ascG 6146475 ascG Escherichia coli SMS-3-5 transcriptional regulator AscG YP_001744862.1 2913420 R 439855 CDS YP_001744863.1 170682118 6147332 2914690..2916147 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 2916147 ascF 6147332 ascF Escherichia coli SMS-3-5 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC YP_001744863.1 2914690 D 439855 CDS YP_001744864.1 170680422 6146316 2916156..2917580 1 NC_010498.1 identified by match to protein family HMM PF00232; cryptic 6-phospho-beta-glucosidase 2917580 ascB 6146316 ascB Escherichia coli SMS-3-5 cryptic 6-phospho-beta-glucosidase YP_001744864.1 2916156 D 439855 CDS YP_001744865.1 170679781 6144591 complement(2917667..2918422) 1 NC_010498.1 identified by similarity to GB:AAN81725.1; hypothetical protein 2918422 6144591 EcSMS35_2841 Escherichia coli SMS-3-5 hypothetical protein YP_001744865.1 2917667 R 439855 CDS YP_001744866.1 170679984 6143941 complement(2918465..2918935) 1 NC_010498.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 2918935 hycI 6143941 hycI Escherichia coli SMS-3-5 hydrogenase 3 maturation protease YP_001744866.1 2918465 R 439855 CDS YP_001744867.1 170684245 6144146 complement(2918928..2919338) 1 NC_010498.1 identified by match to protein family HMM PF07450; formate hydrogenlyase maturation protein 2919338 6144146 EcSMS35_2843 Escherichia coli SMS-3-5 formate hydrogenlyase maturation protein YP_001744867.1 2918928 R 439855 CDS YP_001744868.1 170683663 6143546 complement(2919335..2920102) 1 NC_010498.1 identified by match to protein family HMM PF01058; formate hydrogenlyase, subunit G 2920102 hycG 6143546 hycG Escherichia coli SMS-3-5 formate hydrogenlyase, subunit G YP_001744868.1 2919335 R 439855 CDS YP_001744869.1 170682605 6142955 complement(2920102..2920644) 1 NC_010498.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 2920644 hycF 6142955 hycF Escherichia coli SMS-3-5 formate hydrogenlyase complex iron-sulfur subunit YP_001744869.1 2920102 R 439855 CDS YP_001744870.1 170681957 6146810 complement(2920654..2922384) 1 NC_010498.1 identified by match to protein family HMM PF00329; match to protein family HMM PF00346; formate hydrogenlyase, subunit E 2922384 hycE 6146810 hycE Escherichia coli SMS-3-5 formate hydrogenlyase, subunit E YP_001744870.1 2920654 R 439855 CDS YP_001744871.1 170681545 6146153 complement(2922381..2923304) 1 NC_010498.1 identified by match to protein family HMM PF00146; formate hydrogenlyase, subunit D 2923304 hycD 6146153 hycD Escherichia coli SMS-3-5 formate hydrogenlyase, subunit D YP_001744871.1 2922381 R 439855 CDS YP_001744872.1 170679710 6145730 complement(2923307..2925133) 1 NC_010498.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 2925133 hycC 6145730 hycC Escherichia coli SMS-3-5 formate hydrogenlyase subunit 3 YP_001744872.1 2923307 R 439855 CDS YP_001744873.1 170684164 6143868 complement(2925130..2925741) 1 NC_010498.1 identified by match to protein family HMM PF00037; formate hydrogenlyase, subunit B 2925741 hycB 6143868 hycB Escherichia coli SMS-3-5 formate hydrogenlyase, subunit B YP_001744873.1 2925130 R 439855 CDS YP_001744874.1 170682463 6143464 complement(2925866..2926327) 1 NC_010498.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 2926327 hycA 6143464 hycA Escherichia coli SMS-3-5 formate hydrogenlyase regulatory protein HycA YP_001744874.1 2925866 R 439855 CDS YP_001744875.1 170682833 6146662 2926527..2926889 1 NC_010498.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2926889 hypA 6146662 hypA Escherichia coli SMS-3-5 hydrogenase nickel incorporation protein YP_001744875.1 2926527 D 439855 CDS YP_001744876.1 170682287 6147044 2926893..2927765 1 NC_010498.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2927765 hypB 6147044 hypB Escherichia coli SMS-3-5 hydrogenase nickel incorporation protein HypB YP_001744876.1 2926893 D 439855 CDS YP_001744877.1 170682922 6146486 2927756..2928028 1 NC_010498.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2928028 hypC2 6146486 hypC2 Escherichia coli SMS-3-5 hydrogenase assembly chaperone YP_001744877.1 2927756 D 439855 CDS YP_001744878.1 170680888 6147136 2928028..2929149 1 NC_010498.1 identified by match to protein family HMM PF01924; match to protein family HMM TIGR00075; hydrogenase expression/formation protein HypD 2929149 hypD 6147136 hypD Escherichia coli SMS-3-5 hydrogenase expression/formation protein HypD YP_001744878.1 2928028 D 439855 CDS YP_001744879.1 170681565 6145066 2929146..2930156 1 NC_010498.1 identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124; hydrogenase expression/formation protein HypE 2930156 hypE 6145066 hypE Escherichia coli SMS-3-5 hydrogenase expression/formation protein HypE YP_001744879.1 2929146 D 439855 CDS YP_001744880.1 170679601 6145750 2930230..2932308 1 NC_010498.1 identified by match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; match to protein family HMM PF07728; formate hydrogenlyase transcriptional activator 2932308 fhlA 6145750 fhlA Escherichia coli SMS-3-5 formate hydrogenlyase transcriptional activator YP_001744880.1 2930230 D 439855 CDS YP_001744881.1 170683621 6143758 2932314..2932781 1 NC_010498.1 identified by match to protein family HMM PF03459; match to protein family HMM TIGR00638; molybdenum-pterin binding protein 2932781 6143758 EcSMS35_2857 Escherichia coli SMS-3-5 molybdenum-pterin binding protein YP_001744881.1 2932314 D 439855 CDS YP_001744882.1 170684241 6142911 complement(2932820..2933164) 1 NC_010498.1 ygbA; hypothetical protein 2933164 6142911 EcSMS35_2858 Escherichia coli SMS-3-5 hypothetical protein YP_001744882.1 2932820 R 439855 CDS YP_001744883.1 170680236 6143542 complement(2933241..2933375) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2933375 6143542 EcSMS35_2859 Escherichia coli SMS-3-5 hypothetical protein YP_001744883.1 2933241 R 439855 CDS YP_001744884.1 170680116 6144403 2933451..2936012 1 NC_010498.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2936012 mutS 6144403 mutS Escherichia coli SMS-3-5 DNA mismatch repair protein MutS YP_001744884.1 2933451 D 439855 CDS YP_001744885.1 170680634 6144281 2936118..2936774 1 NC_010498.1 identified by similarity to SP:P55799; match to protein family HMM PF00149; serine/threonine-specific protein phosphatase 2 2936774 pphB 6144281 pphB Escherichia coli SMS-3-5 serine/threonine-specific protein phosphatase 2 YP_001744885.1 2936118 D 439855 CDS YP_001744886.1 170681138 6144809 complement(2936816..2937052) 1 NC_010498.1 4-hydroxybenzoate decarboxylase, subunit D 2937052 kpdD 6144809 kpdD Escherichia coli SMS-3-5 4-hydroxybenzoate decarboxylase, subunit D YP_001744886.1 2936816 R 439855 CDS YP_001744887.1 170681645 6145321 complement(2937063..2938490) 1 NC_010498.1 identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; 4-hydroxybenzoate decarboxylase, subunit C 2938490 kpdC 6145321 kpdC Escherichia coli SMS-3-5 4-hydroxybenzoate decarboxylase, subunit C YP_001744887.1 2937063 R 439855 CDS YP_001744888.1 170682784 6145831 complement(2938490..2939083) 1 NC_010498.1 identified by match to protein family HMM PF02441; match to protein family HMM TIGR00421; 4-hydroxybenzoate decarboxylase, subunit B 2939083 kpdB 6145831 kpdB Escherichia coli SMS-3-5 4-hydroxybenzoate decarboxylase, subunit B YP_001744888.1 2938490 R 439855 CDS YP_001744889.1 170683273 6146993 2939230..2939637 1 NC_010498.1 identified by match to protein family HMM PF01047; MarR family transcriptional regulator 2939637 6146993 EcSMS35_2865 Escherichia coli SMS-3-5 MarR family transcriptional regulator YP_001744889.1 2939230 D 439855 CDS YP_001744890.1 170684160 6147499 complement(2939757..2940749) 1 NC_010498.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 2940749 rpoS 6147499 rpoS Escherichia coli SMS-3-5 RNA polymerase sigma factor RpoS YP_001744890.1 2939757 R 439855 CDS YP_001744891.1 170679671 6143460 complement(2940812..2941951) 1 NC_010498.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 2941951 nlpD 6143460 nlpD Escherichia coli SMS-3-5 lipoprotein NlpD YP_001744891.1 2940812 R 439855 CDS YP_001744892.1 170682160 6143829 complement(2942091..2942717) 1 NC_010498.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 2942717 pcm 6143829 pcm Escherichia coli SMS-3-5 protein-L-isoaspartate O-methyltransferase YP_001744892.1 2942091 R 439855 CDS YP_001744893.1 170681369 6146359 complement(2942711..2943478) 1 NC_010498.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2943478 surE 6146359 surE Escherichia coli SMS-3-5 stationary phase survival protein SurE YP_001744893.1 2942711 R 439855 CDS YP_001744894.1 170681051 6145553 complement(2943453..2944502) 1 NC_010498.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2944502 truD 6145553 truD Escherichia coli SMS-3-5 tRNA pseudouridine synthase D YP_001744894.1 2943453 R 439855 CDS YP_001744895.1 170680373 6145232 complement(2944499..2944978) 1 NC_010498.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2944978 ispF 6145232 ispF Escherichia coli SMS-3-5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_001744895.1 2944499 R 439855 CDS YP_001744896.1 170681257 6144541 complement(2944978..2945688) 1 NC_010498.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2945688 ispD 6144541 ispD Escherichia coli SMS-3-5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001744896.1 2944978 R 439855 CDS YP_001744897.1 170680593 6145441 complement(2945707..2946018) 1 NC_010498.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 2946018 ftsB 6145441 ftsB Escherichia coli SMS-3-5 cell division protein FtsB YP_001744897.1 2945707 R 439855 CDS YP_001744898.1 170682170 6144765 complement(2946006..2946125) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2946125 6144765 EcSMS35_2874 Escherichia coli SMS-3-5 hypothetical protein YP_001744898.1 2946006 R 439855 CDS YP_001744899.1 170681455 6146369 complement(2946212..2946535) 1 NC_010498.1 hypothetical protein 2946535 6146369 EcSMS35_2875 Escherichia coli SMS-3-5 hypothetical protein YP_001744899.1 2946212 R 439855 CDS YP_001744900.1 170683859 6145640 complement(2946585..2947190) 1 NC_010498.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 2947190 cysC 6145640 cysC Escherichia coli SMS-3-5 adenylylsulfate kinase YP_001744900.1 2946585 R 439855 CDS YP_001744901.1 170683324 6143154 complement(2947190..2948617) 1 NC_010498.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 2948617 cysN 6143154 cysN Escherichia coli SMS-3-5 sulfate adenylyltransferase subunit 1 YP_001744901.1 2947190 R 439855 CDS YP_001744902.1 170679929 6142609 complement(2948619..2949527) 1 NC_010498.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2949527 cysD 6142609 cysD Escherichia coli SMS-3-5 sulfate adenylyltransferase subunit 2 YP_001744902.1 2948619 R 439855 CDS YP_001744903.1 170683777 6144091 2949779..2950816 1 NC_010498.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2950816 iap 6144091 iap Escherichia coli SMS-3-5 alkaline phosphatase isozyme conversion aminopeptidase YP_001744903.1 2949779 D 439855 CDS YP_001744905.1 170682057 6147493 2951918..2952031 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2952031 6147493 EcSMS35_2881 Escherichia coli SMS-3-5 hypothetical protein YP_001744905.1 2951918 D 439855 CDS YP_001744906.1 170684220 6146254 complement(2952306..2952593) 1 NC_010498.1 identified by match to protein family HMM TIGR01873; hypothetical protein 2952593 cas2 6146254 cas2 Escherichia coli SMS-3-5 hypothetical protein YP_001744906.1 2952306 R 439855 CDS YP_001744907.1 170681830 6143521 complement(2952596..2953519) 1 NC_010498.1 identified by match to protein family HMM TIGR00287; CRISPR-associated Cas1 family protein 2953519 cas1 6143521 cas1 Escherichia coli SMS-3-5 CRISPR-associated Cas1 family protein YP_001744907.1 2952596 R 439855 CDS YP_001744908.1 170681320 6146023 complement(2953516..2954166) 1 NC_010498.1 identified by match to protein family HMM PF08798; match to protein family HMM TIGR01907; CRISPR-associated Cse3 family protein 2954166 cse3 6146023 cse3 Escherichia coli SMS-3-5 CRISPR-associated Cse3 family protein YP_001744908.1 2953516 R 439855 CDS YP_001744909.1 170680474 6145504 complement(2954148..2954894) 1 NC_010498.1 identified by match to protein family HMM TIGR01868; match to protein family HMM TIGR02593; CRISPR-associated Cas5 family protein 2954894 cas5e 6145504 cas5e Escherichia coli SMS-3-5 CRISPR-associated Cas5 family protein YP_001744909.1 2954148 R 439855 CDS YP_001744910.1 170679971 6144643 complement(2954905..2955960) 1 NC_010498.1 identified by match to protein family HMM TIGR01869; CRISPR-associated Cse4 family protein 2955960 cse4 6144643 cse4 Escherichia coli SMS-3-5 CRISPR-associated Cse4 family protein YP_001744910.1 2954905 R 439855 CDS YP_001744911.1 170680421 6144133 complement(2955975..2956511) 1 NC_010498.1 identified by match to protein family HMM TIGR02548; CRISPR-associated Cse2 family protein 2956511 cse2 6144133 cse2 Escherichia coli SMS-3-5 CRISPR-associated Cse2 family protein YP_001744911.1 2955975 R 439855 CDS YP_001744912.1 170683207 6144590 complement(2956508..2958070) 1 NC_010498.1 identified by match to protein family HMM TIGR02547; CRISPR-associated Cse1 family protein 2958070 cse1 6144590 cse1 Escherichia coli SMS-3-5 CRISPR-associated Cse1 family protein YP_001744912.1 2956508 R 439855 CDS YP_001744913.1 170680605 6147428 complement(2958168..2960867) 1 NC_010498.1 identified by match to protein family HMM TIGR01587; CRISPR-associated helicase Cas3 2960867 cas3 6147428 cas3 Escherichia coli SMS-3-5 CRISPR-associated helicase Cas3 YP_001744913.1 2958168 R 439855 CDS YP_001744914.1 170680095 6144779 complement(2961479..2962213) 1 NC_010498.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2962213 cysH 6144779 cysH Escherichia coli SMS-3-5 phosphoadenosine phosphosulfate reductase YP_001744914.1 2961479 R 439855 CDS YP_001744915.1 170681318 6144259 complement(2962287..2963999) 1 NC_010498.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2963999 cysI 6144259 cysI Escherichia coli SMS-3-5 sulfite reductase subunit beta YP_001744915.1 2962287 R 439855 CDS YP_001744916.1 170680548 6145502 complement(2963999..2965798) 1 NC_010498.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 2965798 cysJ 6145502 cysJ Escherichia coli SMS-3-5 sulfite reductase subunit alpha YP_001744916.1 2963999 R 439855 CDS YP_001744917.1 170682745 6144718 complement(2966011..2966124) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2966124 6144718 EcSMS35_2893 Escherichia coli SMS-3-5 hypothetical protein YP_001744917.1 2966011 R 439855 CDS YP_001744918.1 170682185 6146953 2966117..2966479 1 NC_010498.1 identified by match to protein family HMM PF01242; match to protein family HMM TIGR00039; match to protein family HMM TIGR03367; queuosine biosynthesis protein QueD 2966479 queD 6146953 queD Escherichia coli SMS-3-5 queuosine biosynthesis protein QueD YP_001744918.1 2966117 D 439855 CDS YP_001744919.1 170683360 6146384 2966557..2967828 1 NC_010498.1 identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM PF03486; match to protein family HMM PF07992; pyridine nucleotide-disulphide oxidoreductase family protein 2967828 6146384 EcSMS35_2895 Escherichia coli SMS-3-5 pyridine nucleotide-disulphide oxidoreductase family protein YP_001744919.1 2966557 D 439855 CDS YP_001744920.1 170682567 6142646 2967819..2968079 1 NC_010498.1 identified by match to protein family HMM PF00037; putative ferredoxin 2968079 6142646 EcSMS35_2896 Escherichia coli SMS-3-5 putative ferredoxin YP_001744920.1 2967819 D 439855 CDS YP_001744921.1 170679687 6146772 2968096..2968671 1 NC_010498.1 identified by match to protein family HMM PF04309; glycerol-3-phosphate responsive antiterminator 2968671 6146772 EcSMS35_2897 Escherichia coli SMS-3-5 glycerol-3-phosphate responsive antiterminator YP_001744921.1 2968096 D 439855 CDS YP_001744922.1 170682876 6143845 complement(2968818..2969678) 1 NC_010498.1 identified by match to protein family HMM PF00766; electron transfer flavoprotein 2969678 6143845 EcSMS35_2898 Escherichia coli SMS-3-5 electron transfer flavoprotein YP_001744922.1 2968818 R 439855 CDS YP_001744923.1 170680852 6147089 complement(2969675..2970454) 1 NC_010498.1 identified by match to protein family HMM PF01012; electron transfer flavoprotein 2970454 6147089 EcSMS35_2899 Escherichia coli SMS-3-5 electron transfer flavoprotein YP_001744923.1 2969675 R 439855 CDS YP_001744924.1 170681816 6145029 complement(2970432..2971769) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 2971769 6145029 EcSMS35_2900 Escherichia coli SMS-3-5 major facilitator family transporter YP_001744924.1 2970432 R 439855 CDS YP_001744925.1 170679795 6146009 complement(2971863..2973317) 1 NC_010498.1 identified by match to protein family HMM PF01565; match to protein family HMM PF02913; FAD binding domain-containing protein 2973317 6146009 EcSMS35_2901 Escherichia coli SMS-3-5 FAD binding domain-containing protein YP_001744925.1 2971863 R 439855 CDS YP_001744926.1 170680420 6143955 complement(2973387..2974172) 1 NC_010498.1 identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase 2974172 6143955 EcSMS35_2902 Escherichia coli SMS-3-5 short chain dehydrogenase/reductase family oxidoreductase YP_001744926.1 2973387 R 439855 CDS YP_001744927.1 170683431 6144589 2974490..2975767 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator family transporter 2975767 6144589 EcSMS35_2903 Escherichia coli SMS-3-5 major facilitator family transporter YP_001744927.1 2974490 D 439855 CDS YP_001744928.1 170679797 6142718 2975794..2977272 1 NC_010498.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; carbohydrate kinase, FGGY family protein 2977272 6142718 EcSMS35_2904 Escherichia coli SMS-3-5 carbohydrate kinase, FGGY family protein YP_001744928.1 2975794 D 439855 CDS YP_001744929.1 170682402 6143957 2977437..2978357 1 NC_010498.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2978357 scrK 6143957 scrK Escherichia coli SMS-3-5 aminoimidazole riboside kinase YP_001744929.1 2977437 D 439855 CDS YP_001744930.1 170682892 6146601 2978525..2980042 1 NC_010498.1 identified by similarity to SP:P22340; match to protein family HMM PF02264; sucrose porin ScrY 2980042 scrY 6146601 scrY Escherichia coli SMS-3-5 sucrose porin ScrY YP_001744930.1 2978525 D 439855 CDS YP_001744931.1 170681405 6147105 2980103..2981473 1 NC_010498.1 identified by similarity to SP:P08470; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00852; match to protein family HMM TIGR01996; PTS system sucrose-specific EIIBC component ScrA 2981473 scrA 6147105 scrA Escherichia coli SMS-3-5 PTS system sucrose-specific EIIBC component ScrA YP_001744931.1 2980103 D 439855 CDS YP_001744932.1 170680697 6145589 2981479..2982882 1 NC_010498.1 identified by similarity to SP:P37075; match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; beta-fructofuranosidase 2982882 scrB 6145589 scrB Escherichia coli SMS-3-5 beta-fructofuranosidase YP_001744932.1 2981479 D 439855 CDS YP_001744933.1 170682803 6144872 2982908..2983915 1 NC_010498.1 identified by similarity to SP:P37076; match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR02417; sucrose operon repressor 2983915 scrR 6144872 scrR Escherichia coli SMS-3-5 sucrose operon repressor YP_001744933.1 2982908 D 439855 CDS YP_001744934.1 170682101 6147014 complement(2984001..2984672) 1 NC_010498.1 hypothetical protein 2984672 6147014 EcSMS35_2910 Escherichia coli SMS-3-5 hypothetical protein YP_001744934.1 2984001 R 439855 CDS YP_001744935.1 170681100 6146299 2984706..2984819 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 2984819 6146299 EcSMS35_2911 Escherichia coli SMS-3-5 hypothetical protein YP_001744935.1 2984706 D 439855 CDS YP_001744936.1 170682799 6145282 2984845..2985447 1 NC_010498.1 identified by match to protein family HMM PF04011; LemA family protein 2985447 6145282 EcSMS35_2912 Escherichia coli SMS-3-5 LemA family protein YP_001744936.1 2984845 D 439855 CDS YP_001744937.1 170680054 6147008 2985461..2986354 1 NC_010498.1 identified by similarity to GB:ABF04769.1; match to protein family HMM PF04536; hypothetical protein 2986354 6147008 EcSMS35_2913 Escherichia coli SMS-3-5 hypothetical protein YP_001744937.1 2985461 D 439855 CDS YP_001744938.1 170681683 6144218 2986369..2987517 1 NC_010498.1 identified by match to protein family HMM PF04536; hypothetical protein 2987517 6144218 EcSMS35_2914 Escherichia coli SMS-3-5 hypothetical protein YP_001744938.1 2986369 D 439855 CDS YP_001744939.1 170683146 6145869 2987511..2988395 1 NC_010498.1 identified by match to protein family HMM PF04536; hypothetical protein 2988395 6145869 EcSMS35_2915 Escherichia coli SMS-3-5 hypothetical protein YP_001744939.1 2987511 D 439855 CDS YP_001744940.1 170680259 6147366 2988512..2989840 1 NC_010498.1 identified by match to protein family HMM PF01609; IS4 transposase 2989840 6147366 EcSMS35_2916 Escherichia coli SMS-3-5 IS4 transposase YP_001744940.1 2988512 D 439855 CDS YP_001744941.1 170684207 6144426 complement(2989895..2991193) 1 NC_010498.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 2991193 eno 6144426 eno Escherichia coli SMS-3-5 phosphopyruvate hydratase YP_001744941.1 2989895 R 439855 CDS YP_001744942.1 170680423 6143508 complement(2991280..2992917) 1 NC_010498.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2992917 pyrG 6143508 pyrG Escherichia coli SMS-3-5 CTP synthetase YP_001744942.1 2991280 R 439855 CDS YP_001744943.1 170682107 6144592 complement(2993145..2993936) 1 NC_010498.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 2993936 mazG 6144592 mazG Escherichia coli SMS-3-5 nucleoside triphosphate pyrophosphohydrolase YP_001744943.1 2993145 R 439855 CDS YP_001744944.1 170683531 6146305 complement(2994008..2994343) 1 NC_010498.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 2994343 chpA 6146305 chpA Escherichia coli SMS-3-5 toxin ChpA YP_001744944.1 2994008 R 439855 CDS YP_001744945.1 170682877 6142821 complement(2994343..2994591) 1 NC_010498.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 2994591 chpR 6142821 chpR Escherichia coli SMS-3-5 antitoxin MazE YP_001744945.1 2994343 R 439855 CDS YP_001744946.1 170682452 6147090 complement(2994669..2996903) 1 NC_010498.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 2996903 relA 6147090 relA Escherichia coli SMS-3-5 GDP/GTP pyrophosphokinase YP_001744946.1 2994669 R 439855 CDS YP_001744947.1 170681551 6146651 complement(2996951..2998252) 1 NC_010498.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 2998252 rumA 6146651 rumA Escherichia coli SMS-3-5 23S rRNA 5-methyluridine methyltransferase YP_001744947.1 2996951 R 439855 CDS YP_001744948.1 170680902 6145736 2998309..3001065 1 NC_010498.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3001065 barA 6145736 barA Escherichia coli SMS-3-5 hybrid sensory histidine kinase BarA YP_001744948.1 2998309 D 439855 CDS YP_001744949.1 170680334 6145081 complement(3001296..3002636) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM TIGR03247; glucarate dehydratase 3002636 6145081 EcSMS35_2925 Escherichia coli SMS-3-5 glucarate dehydratase YP_001744949.1 3001296 R 439855 CDS YP_001744950.1 170679833 6144502 complement(3002657..3003997) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; glucarate dehydratase 3003997 6144502 EcSMS35_2926 Escherichia coli SMS-3-5 glucarate dehydratase YP_001744950.1 3002657 R 439855 CDS YP_001744951.1 170684213 6143995 complement(3003999..3005351) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; glucarate permease 3005351 gudP 6143995 gudP Escherichia coli SMS-3-5 glucarate permease YP_001744951.1 3003999 R 439855 CDS YP_001744952.1 170683781 6143514 complement(3005446..3005571) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3005571 6143514 EcSMS35_2928 Escherichia coli SMS-3-5 hypothetical protein YP_001744952.1 3005446 R 439855 CDS YP_001744953.1 170681822 6143073 3005565..3005693 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3005693 6143073 EcSMS35_2929 Escherichia coli SMS-3-5 hypothetical protein YP_001744953.1 3005565 D 439855 CDS YP_001744954.1 170679697 6146015 complement(3005786..3006235) 1 NC_010498.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3006235 6146015 EcSMS35_2930 Escherichia coli SMS-3-5 flavodoxin YP_001744954.1 3005786 R 439855 CDS YP_001744955.1 170682843 6143855 complement(3006253..3007035) 1 NC_010498.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3007035 truC 6143855 truC Escherichia coli SMS-3-5 tRNA pseudouridine synthase C YP_001744955.1 3006253 R 439855 CDS YP_001744956.1 170681308 6147055 complement(3007035..3007364) 1 NC_010498.1 identified by match to protein family HMM PF04287; hypothetical protein 3007364 6147055 EcSMS35_2932 Escherichia coli SMS-3-5 hypothetical protein YP_001744956.1 3007035 R 439855 CDS YP_001744957.1 170683510 6145492 complement(3007986..3008531) 1 NC_010498.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3008531 6145492 EcSMS35_2933 Escherichia coli SMS-3-5 SecY interacting protein Syd YP_001744957.1 3007986 R 439855 CDS YP_001744958.1 170684047 6142799 3008599..3009447 1 NC_010498.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3009447 queF 6142799 queF Escherichia coli SMS-3-5 7-cyano-7-deazaguanine reductase YP_001744958.1 3008599 D 439855 CDS YP_001744959.1 170680380 6143346 3009559..3010923 1 NC_010498.1 identified by match to protein family HMM PF03641; hypothetical protein 3010923 6143346 EcSMS35_2935 Escherichia coli SMS-3-5 hypothetical protein YP_001744959.1 3009559 D 439855 CDS YP_001744960.1 170683290 6144549 3011479..3012768 1 NC_010498.1 identified by match to protein family HMM TIGR00814; serine transporter family protein 3012768 6144549 EcSMS35_2936 Escherichia coli SMS-3-5 serine transporter family protein YP_001744960.1 3011479 D 439855 CDS YP_001744961.1 170680778 6147516 3012826..3014193 1 NC_010498.1 identified by similarity to SP:P30744; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase 2 3014193 sdaB 6147516 sdaB Escherichia coli SMS-3-5 L-serine ammonia-lyase 2 YP_001744961.1 3012826 D 439855 CDS YP_001744962.1 170681600 6144953 3014304..3015059 1 NC_010498.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3015059 xni 6144953 xni Escherichia coli SMS-3-5 exonuclease IX YP_001744962.1 3014304 D 439855 CDS YP_001744963.1 170682829 6145785 complement(3015164..3016315) 1 NC_010498.1 identified by match to protein family HMM PF00465; match to protein family HMM TIGR02638; L-1,2-propanediol oxidoreductase 3016315 fucO 6145785 fucO Escherichia coli SMS-3-5 L-1,2-propanediol oxidoreductase YP_001744963.1 3015164 R 439855 CDS YP_001744964.1 170682130 6147040 complement(3016340..3016987) 1 NC_010498.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3016987 fucA 6147040 fucA Escherichia coli SMS-3-5 L-fuculose phosphate aldolase YP_001744964.1 3016340 R 439855 CDS YP_001744965.1 170683834 6146329 3017177..3017314 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3017314 6146329 EcSMS35_2941 Escherichia coli SMS-3-5 hypothetical protein YP_001744965.1 3017177 D 439855 CDS YP_001744966.1 170683163 6143128 3017534..3018850 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00885; L-fucose transporter 3018850 fucP 6143128 fucP Escherichia coli SMS-3-5 L-fucose transporter YP_001744966.1 3017534 D 439855 CDS YP_001744967.1 170682875 6147383 3018883..3020658 1 NC_010498.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3020658 fucI 6147383 fucI Escherichia coli SMS-3-5 L-fucose isomerase YP_001744967.1 3018883 D 439855 CDS YP_001744968.1 170682163 6147088 3020767..3022185 1 NC_010498.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR02628; L-fuculokinase 3022185 fucK 6147088 fucK Escherichia coli SMS-3-5 L-fuculokinase YP_001744968.1 3020767 D 439855 CDS YP_001744969.1 170683884 6146362 3022187..3022609 1 NC_010498.1 identified by match to protein family HMM PF05025; fucose operon protein FucU 3022609 fucU 6146362 fucU Escherichia coli SMS-3-5 fucose operon protein FucU YP_001744969.1 3022187 D 439855 CDS YP_001744970.1 170683158 6143179 3022667..3023398 1 NC_010498.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3023398 fucR 6143179 fucR Escherichia coli SMS-3-5 DNA-binding transcriptional activator FucR YP_001744970.1 3022667 D 439855 CDS YP_001744971.1 170680808 6147378 complement(3023442..3024542) 1 NC_010498.1 putative RNA 2'-O-ribose methyltransferase 3024542 6147378 EcSMS35_2947 Escherichia coli SMS-3-5 putative RNA 2'-O-ribose methyltransferase YP_001744971.1 3023442 R 439855 CDS YP_001744972.1 170684153 6144984 complement(3024535..3024930) 1 NC_010498.1 identified by match to protein family HMM PF04241; hypothetical protein 3024930 6144984 EcSMS35_2948 Escherichia coli SMS-3-5 hypothetical protein YP_001744972.1 3024535 R 439855 CDS YP_001744973.1 170681756 6143453 complement(3024949..3025866) 1 NC_010498.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3025866 gcvA 6143453 gcvA Escherichia coli SMS-3-5 DNA-binding transcriptional activator GcvA YP_001744973.1 3024949 R 439855 CDS YP_001744974.1 170682370 6145947 complement(3026218..3026445) 1 NC_010498.1 identified by match to protein family HMM PF06004; putative lipoprotein 3026445 6145947 EcSMS35_2950 Escherichia coli SMS-3-5 putative lipoprotein YP_001744974.1 3026218 R 439855 CDS YP_001744975.1 170680672 6146569 3026637..3027842 1 NC_010498.1 identified by match to protein family HMM PF00266; match to protein family HMM TIGR03392; cysteine sulfinate desulfinase 3027842 csdA 6146569 csdA Escherichia coli SMS-3-5 cysteine sulfinate desulfinase YP_001744975.1 3026637 D 439855 CDS YP_001744976.1 170681430 6144847 3027842..3028285 1 NC_010498.1 identified by match to protein family HMM PF02657; match to protein family HMM TIGR03391; cysteine desulfurase, sulfur acceptor subunit CsdE 3028285 csdE 6144847 csdE Escherichia coli SMS-3-5 cysteine desulfurase, sulfur acceptor subunit CsdE YP_001744976.1 3027842 D 439855 CDS YP_001744977.1 170680315 6145614 complement(3028336..3029136) 1 NC_010498.1 identified by match to protein family HMM PF00899; ThiF family protein 3029136 6145614 EcSMS35_2953 Escherichia coli SMS-3-5 ThiF family protein YP_001744977.1 3028336 R 439855 CDS YP_001744978.1 170681128 6144483 complement(3029219..3030286) 1 NC_010498.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3030286 mltA 6144483 mltA Escherichia coli SMS-3-5 murein transglycosylase A YP_001744978.1 3029219 R 439855 CDS YP_001744979.1 170684118 6143708 complement(3030901..3031848) 1 NC_010498.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase family protein 3031848 6143708 EcSMS35_2958 Escherichia coli SMS-3-5 D-isomer specific 2-hydroxyacid dehydrogenase family protein YP_001744979.1 3030901 R 439855 CDS YP_001744980.1 170680141 6143418 complement(3031920..3032516) 1 NC_010498.1 identified by match to protein family HMM PF01380; KpsF/GutQ family sugar isomerase 3032516 6143418 EcSMS35_2959 Escherichia coli SMS-3-5 KpsF/GutQ family sugar isomerase YP_001744980.1 3031920 R 439855 CDS YP_001744981.1 170682367 6144307 complement(3032519..3033694) 1 NC_010498.1 identified by match to protein family HMM PF00155; aminotransferase, classes I and II 3033694 6144307 EcSMS35_2960 Escherichia coli SMS-3-5 aminotransferase, classes I and II YP_001744981.1 3032519 R 439855 CDS YP_001744982.1 170683282 6146566 complement(3033694..3035274) 1 NC_010498.1 identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; PTS system, maltose and glucose-specific IIBC component family protein 3035274 6146566 EcSMS35_2961 Escherichia coli SMS-3-5 PTS system, maltose and glucose-specific IIBC component family protein YP_001744982.1 3033694 R 439855 CDS YP_001744983.1 170680940 6147508 complement(3035306..3036130) 1 NC_010498.1 identified by match to protein family HMM PF00874; match to protein family HMM PF03123; putative transcriptional antiterminator 3036130 6147508 EcSMS35_2962 Escherichia coli SMS-3-5 putative transcriptional antiterminator YP_001744983.1 3035306 R 439855 CDS YP_001744984.1 170681355 6145121 3036226..3036378 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3036378 6145121 EcSMS35_2963 Escherichia coli SMS-3-5 hypothetical protein YP_001744984.1 3036226 D 439855 CDS YP_001744985.1 170681690 6145539 complement(3036388..3037641) 1 NC_010498.1 identified by similarity to SP:P63883; match to protein family HMM PF01520; match to protein family HMM TIGR01409; N-acetylmuramoyl-L-alanine amidase AmiC 3037641 amiC1 6145539 amiC1 Escherichia coli SMS-3-5 N-acetylmuramoyl-L-alanine amidase AmiC YP_001744985.1 3036388 R 439855 CDS YP_001744986.1 170680431 6145876 3037873..3039204 1 NC_010498.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3039204 argA 6145876 argA Escherichia coli SMS-3-5 N-acetylglutamate synthase YP_001744986.1 3037873 D 439855 CDS YP_001744987.1 170683529 6144600 complement(3039266..3041092) 1 NC_010498.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3041092 recD 6144600 recD Escherichia coli SMS-3-5 exonuclease V subunit alpha YP_001744987.1 3039266 R 439855 CDS YP_001744988.1 170684073 6142819 complement(3041092..3044604) 1 NC_010498.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3044604 recB 6142819 recB Escherichia coli SMS-3-5 exonuclease V subunit beta YP_001744988.1 3041092 R 439855 CDS YP_001744989.1 170682458 6143373 complement(3044627..3047515) 1 NC_010498.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193; protease III 3047515 ptrA 6143373 ptrA Escherichia coli SMS-3-5 protease III YP_001744989.1 3044627 R 439855 CDS YP_001744990.1 170683034 6146657 complement(3047691..3051059) 1 NC_010498.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3051059 recC 6146657 recC Escherichia coli SMS-3-5 exonuclease V subunit gamma YP_001744990.1 3047691 R 439855 CDS YP_001744991.1 170682705 6147250 complement(3051072..3051419) 1 NC_010498.1 identified by match to protein family HMM TIGR02532; hypothetical protein 3051419 ppdC 6147250 ppdC Escherichia coli SMS-3-5 hypothetical protein YP_001744991.1 3051072 R 439855 CDS YP_001744992.1 170683020 6146913 complement(3051380..3051787) 1 NC_010498.1 hypothetical protein 3051787 6146913 EcSMS35_2971 Escherichia coli SMS-3-5 hypothetical protein YP_001744992.1 3051380 R 439855 CDS YP_001744993.1 170680768 6147236 complement(3051784..3052347) 1 NC_010498.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; hypothetical protein 3052347 ppdB 6147236 ppdB Escherichia coli SMS-3-5 hypothetical protein YP_001744993.1 3051784 R 439855 CDS YP_001744994.1 170680414 6144943 complement(3052338..3052808) 1 NC_010498.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; hypothetical protein 3052808 ppdA 6144943 ppdA Escherichia coli SMS-3-5 hypothetical protein YP_001744994.1 3052338 R 439855 CDS YP_001744995.1 170684262 6144583 complement(3052993..3053787) 1 NC_010498.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3053787 thyA 6144583 thyA Escherichia coli SMS-3-5 thymidylate synthase YP_001744995.1 3052993 R 439855 CDS YP_001744996.1 170683817 6143564 complement(3053794..3054669) 1 NC_010498.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3054669 lgt 6143564 lgt Escherichia coli SMS-3-5 prolipoprotein diacylglyceryl transferase YP_001744996.1 3053794 R 439855 CDS YP_001744997.1 170682936 6143111 complement(3054820..3057066) 1 NC_010498.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3057066 ptsP 6143111 ptsP Escherichia coli SMS-3-5 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_001744997.1 3054820 R 439855 CDS YP_001744998.1 170682263 6147150 complement(3057079..3057609) 1 NC_010498.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3057609 nudH 6147150 nudH Escherichia coli SMS-3-5 dinucleoside polyphosphate hydrolase YP_001744998.1 3057079 R 439855 CDS YP_001744999.1 170681598 6146462 3058054..3058215 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3058215 6146462 EcSMS35_2978 Escherichia coli SMS-3-5 hypothetical protein YP_001744999.1 3058054 D 439855 CDS YP_001745000.1 170680941 6145783 3058294..3058983 1 NC_010498.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3058983 mutH 6145783 mutH Escherichia coli SMS-3-5 DNA mismatch repair protein YP_001745000.1 3058294 D 439855 CDS YP_001745001.1 170681603 6145122 3059052..3059765 1 NC_010498.1 identified by match to protein family HMM PF03741; TerC family integral membrane protein 3059765 6145122 EcSMS35_2980 Escherichia coli SMS-3-5 TerC family integral membrane protein YP_001745001.1 3059052 D 439855 CDS YP_001745002.1 170680635 6145788 3059903..3060121 1 NC_010498.1 identified by match to protein family HMM PF06004; putative lipoprotein 3060121 6145788 EcSMS35_2981 Escherichia coli SMS-3-5 putative lipoprotein YP_001745002.1 3059903 D 439855 CDS YP_001745003.1 170681174 6144810 3060229..3061269 1 NC_010498.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3061269 tas 6144810 tas Escherichia coli SMS-3-5 putative aldo-keto reductase YP_001745003.1 3060229 D 439855 CDS YP_001745004.1 170683196 6145358 complement(3061301..3062494) 1 NC_010498.1 identified by match to protein family HMM PF07690; lysophospholipid transporter LplT 3062494 lplT 6145358 lplT Escherichia coli SMS-3-5 lysophospholipid transporter LplT YP_001745004.1 3061301 R 439855 CDS YP_001745005.1 170683715 6147416 complement(3062487..3064646) 1 NC_010498.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3064646 aas 6147416 aas Escherichia coli SMS-3-5 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_001745005.1 3062487 R 439855 CDS YP_001745006.1 170682732 6143007 3065232..3066263 1 NC_010498.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3066263 galR 6143007 galR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator GalR YP_001745006.1 3065232 D 439855 CDS YP_001745007.1 170683211 6146940 complement(3066270..3067532) 1 NC_010498.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3067532 lysA 6146940 lysA Escherichia coli SMS-3-5 diaminopimelate decarboxylase YP_001745007.1 3066270 R 439855 CDS YP_001745008.1 170682032 6147432 3067654..3068589 1 NC_010498.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3068589 lysR 6147432 lysR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator LysR YP_001745008.1 3067654 D 439855 CDS YP_001745009.1 170681384 6146229 complement(3068576..3069268) 1 NC_010498.1 identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; putative racemase 3069268 6146229 EcSMS35_2987 Escherichia coli SMS-3-5 putative racemase YP_001745009.1 3068576 R 439855 CDS YP_001745010.1 170681217 6145568 complement(3069397..3070815) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879; arabinose-proton symporter 3070815 araE 6145568 araE Escherichia coli SMS-3-5 arabinose-proton symporter YP_001745010.1 3069397 R 439855 CDS YP_001745011.1 170681878 6145401 complement(3071130..3071891) 1 NC_010498.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3071891 kduD 6145401 kduD Escherichia coli SMS-3-5 2-deoxy-D-gluconate 3-dehydrogenase YP_001745011.1 3071130 R 439855 CDS YP_001745012.1 170680558 6146072 complement(3071921..3072757) 1 NC_010498.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3072757 kduI 6146072 kduI Escherichia coli SMS-3-5 5-keto-4-deoxyuronate isomerase YP_001745012.1 3071921 R 439855 CDS YP_001745013.1 170680410 6144728 complement(3073044..3074225) 1 NC_010498.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3074225 6144728 EcSMS35_2992 Escherichia coli SMS-3-5 acetyl-CoA acetyltransferase YP_001745013.1 3073044 R 439855 CDS YP_001745014.1 170684281 6144579 3074481..3075710 1 NC_010498.1 identified by match to protein family HMM PF01490; match to protein family HMM TIGR00814; serine transporter family protein 3075710 6144579 EcSMS35_2993 Escherichia coli SMS-3-5 serine transporter family protein YP_001745014.1 3074481 D 439855 CDS YP_001745015.1 170679934 6143583 3076284..3076802 1 NC_010498.1 hypothetical protein 3076802 6143583 EcSMS35_2994 Escherichia coli SMS-3-5 hypothetical protein YP_001745015.1 3076284 D 439855 CDS YP_001745016.1 170682718 6144096 3076987..3077199 1 NC_010498.1 IS1 transposase orfA 3077199 6144096 EcSMS35_2995 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001745016.1 3076987 D 439855 CDS YP_001745017.1 170682615 6146926 3077210..3077713 1 NC_010498.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 3077713 6146926 EcSMS35_2996 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001745017.1 3077210 D 439855 CDS YP_001745018.1 170683156 6143690 complement(3078118..3078870) 1 NC_010498.1 identified by match to protein family HMM PF01476; match to protein family HMM PF01551; M23B family peptidase 3078870 6143690 EcSMS35_2998 Escherichia coli SMS-3-5 M23B family peptidase YP_001745018.1 3078118 R 439855 CDS YP_001745019.1 170681574 6147376 3079286..3081583 1 NC_010498.1 putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3081583 xdhA 6147376 xdhA Escherichia coli SMS-3-5 xanthine dehydrogenase subunit XdhA YP_001745019.1 3079286 D 439855 CDS YP_001745020.1 170682040 6145759 3081594..3082472 1 NC_010498.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3082472 xdhB 6145759 xdhB Escherichia coli SMS-3-5 xanthine dehydrogenase subunit XdhB YP_001745020.1 3081594 D 439855 CDS YP_001745021.1 170681118 6146237 3082469..3082948 1 NC_010498.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3082948 xdhC 6146237 xdhC Escherichia coli SMS-3-5 xanthine dehydrogenase subunit XdhC YP_001745021.1 3082469 D 439855 CDS YP_001745022.1 170681642 6145301 complement(3082988..3084766) 1 NC_010498.1 identified by match to protein family HMM PF00158; match to protein family HMM PF02954; sigma-54 dependent trancsriptional regulator 3084766 6145301 EcSMS35_3002 Escherichia coli SMS-3-5 sigma-54 dependent trancsriptional regulator YP_001745022.1 3082988 R 439855 CDS YP_001745023.1 170682685 6145828 3085243..3086433 1 NC_010498.1 identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR03316; aspartate/ornithine carbamoyltransferase family protein 3086433 6145828 EcSMS35_3003 Escherichia coli SMS-3-5 aspartate/ornithine carbamoyltransferase family protein YP_001745023.1 3085243 D 439855 CDS YP_001745024.1 170681063 6146893 3086491..3087687 1 NC_010498.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3087687 6146893 EcSMS35_3004 Escherichia coli SMS-3-5 diaminopropionate ammonia-lyase YP_001745024.1 3086491 D 439855 CDS YP_001745025.1 170684131 6145245 3087745..3088956 1 NC_010498.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3088956 6145245 EcSMS35_3005 Escherichia coli SMS-3-5 peptidase YP_001745025.1 3087745 D 439855 CDS YP_001745026.1 170682443 6143431 3088997..3090394 1 NC_010498.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3090394 hyuA 6143431 hyuA Escherichia coli SMS-3-5 phenylhydantoinase YP_001745026.1 3088997 D 439855 CDS YP_001745027.1 170680720 6146642 3090442..3091374 1 NC_010498.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3091374 6146642 EcSMS35_3007 Escherichia coli SMS-3-5 carbamate kinase YP_001745027.1 3090442 D 439855 CDS YP_001745028.1 170680222 6144895 complement(3091415..3093040) 1 NC_010498.1 identified by match to protein family HMM PF00364; match to protein family HMM PF02625; match to protein family HMM TIGR03309; putative xanthine dehydrogenase accessory factor 3093040 6144895 EcSMS35_3008 Escherichia coli SMS-3-5 putative xanthine dehydrogenase accessory factor YP_001745028.1 3091415 R 439855 CDS YP_001745029.1 170680868 6144388 complement(3093088..3093858) 1 NC_010498.1 identified by match to protein family HMM TIGR03172; hypothetical protein 3093858 6144388 EcSMS35_3009 Escherichia coli SMS-3-5 hypothetical protein YP_001745029.1 3093088 R 439855 CDS YP_001745030.1 170681481 6145046 3093961..3094539 1 NC_010498.1 identified by match to protein family HMM TIGR03310; hypothetical protein 3094539 6145046 EcSMS35_3010 Escherichia coli SMS-3-5 hypothetical protein YP_001745030.1 3093961 D 439855 CDS YP_001745031.1 170681388 6145666 3094861..3097959 1 NC_010498.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3097959 6145666 EcSMS35_3011 Escherichia coli SMS-3-5 putative selenate reductase subunit YgfK YP_001745031.1 3094861 D 439855 CDS YP_001745032.1 170680729 6145572 3097962..3099290 1 NC_010498.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3099290 ssnA 6145572 ssnA Escherichia coli SMS-3-5 putative chlorohydrolase/aminohydrolase YP_001745032.1 3097962 D 439855 CDS YP_001745033.1 170682210 6144904 3099341..3100120 1 NC_010498.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3100120 6144904 EcSMS35_3013 Escherichia coli SMS-3-5 putative selenate reductase subunit YgfM YP_001745033.1 3099341 D 439855 CDS YP_001745034.1 170683442 6146409 3100117..3102987 1 NC_010498.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3102987 6146409 EcSMS35_3014 Escherichia coli SMS-3-5 putative selenate reductase subunit YgfN YP_001745034.1 3100117 D 439855 CDS YP_001745035.1 170681803 6142729 3103152..3104552 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine/uracil permease family protein 3104552 6142729 EcSMS35_3015 Escherichia coli SMS-3-5 xanthine/uracil permease family protein YP_001745035.1 3103152 D 439855 CDS YP_001745036.1 170682427 6145996 3104570..3105886 1 NC_010498.1 Catalyzes the deamination of guanine; guanine deaminase 3105886 guaD 6145996 guaD Escherichia coli SMS-3-5 guanine deaminase YP_001745036.1 3104570 D 439855 CDS YP_001745037.1 170680723 6146626 3105922..3107289 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease family inorganic anion transporter 3107289 6146626 EcSMS35_3017 Escherichia coli SMS-3-5 sulfate permease family inorganic anion transporter YP_001745037.1 3105922 D 439855 CDS YP_001745038.1 170680835 6144898 complement(3107325..3107813) 1 NC_010498.1 identified by match to protein family HMM PF00037; 4Fe-4S binding protein 3107813 6144898 EcSMS35_3018 Escherichia coli SMS-3-5 4Fe-4S binding protein YP_001745038.1 3107325 R 439855 CDS YP_001745039.1 170683856 6145012 complement(3107813..3109747) 1 NC_010498.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 3109747 aegA2 6145012 aegA2 Escherichia coli SMS-3-5 putative oxidoreductase Fe-S binding subunit YP_001745039.1 3107813 R 439855 CDS YP_001745040.1 170679688 6143151 3110039..3111616 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; putative xanthine permease 3111616 6143151 EcSMS35_3020 Escherichia coli SMS-3-5 putative xanthine permease YP_001745040.1 3110039 D 439855 CDS YP_001745041.1 170683489 6143846 3111618..3111743 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3111743 6143846 EcSMS35_3021 Escherichia coli SMS-3-5 hypothetical protein YP_001745041.1 3111618 D 439855 CDS YP_001745042.1 170684006 6142778 3111866..3112414 1 NC_010498.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3112414 idi 6142778 idi Escherichia coli SMS-3-5 isopentenyl-diphosphate delta-isomerase YP_001745042.1 3111866 D 439855 CDS YP_001745043.1 170682698 6143305 complement(3112457..3113974) 1 NC_010498.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3113974 lysS 6143305 lysS Escherichia coli SMS-3-5 lysyl-tRNA synthetase YP_001745043.1 3112457 R 439855 CDS YP_001745044.1 170682178 6146906 complement(join(3113984..3115006,3115008..3115082)) 1 NC_010498.1 programmed frameshift; recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3115082 prfB 6146906 prfB Escherichia coli SMS-3-5 peptide chain release factor 2 YP_001745044.1 3113984 R 439855 CDS YP_001745045.1 170683389 6146377 complement(3115173..3116906) 1 NC_010498.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3116906 recJ 6146377 recJ Escherichia coli SMS-3-5 ssDNA exonuclease RecJ YP_001745045.1 3115173 R 439855 CDS YP_001745046.1 170682633 6142675 complement(3116912..3117622) 1 NC_010498.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3117622 dsbC 6142675 dsbC Escherichia coli SMS-3-5 thiol:disulfide interchange protein DsbC YP_001745046.1 3116912 R 439855 CDS YP_001745047.1 170681991 6146839 complement(3117647..3118543) 1 NC_010498.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3118543 xerD 6146839 xerD Escherichia coli SMS-3-5 site-specific tyrosine recombinase XerD YP_001745047.1 3117647 R 439855 CDS YP_001745048.1 170683925 6146187 3118655..3119176 1 NC_010498.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3119176 fldB 6146187 fldB Escherichia coli SMS-3-5 flavodoxin FldB YP_001745048.1 3118655 D 439855 CDS YP_001745049.1 170683382 6143221 complement(3119216..3119623) 1 NC_010498.1 identified by match to protein family HMM PF07254; hypothetical protein 3119623 6143221 EcSMS35_3029 Escherichia coli SMS-3-5 hypothetical protein YP_001745049.1 3119216 R 439855 CDS YP_001745050.1 170679885 6142668 complement(3119604..3119870) 1 NC_010498.1 identified by match to protein family HMM PF03937; hypothetical protein 3119870 6142668 EcSMS35_3030 Escherichia coli SMS-3-5 hypothetical protein YP_001745050.1 3119604 R 439855 CDS YP_001745051.1 170683930 6144047 3120113..3121093 1 NC_010498.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3121093 ygfZ 6144047 ygfZ Escherichia coli SMS-3-5 putative global regulator YP_001745051.1 3120113 D 439855 CDS YP_001745052.1 170682502 6143226 complement(3121170..3121829) 1 NC_010498.1 identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin III family channel protein 3121829 6143226 EcSMS35_3032 Escherichia coli SMS-3-5 hemolysin III family channel protein YP_001745052.1 3121170 R 439855 CDS YP_001745053.1 170683063 6146702 complement(3121993..3122304) 1 NC_010498.1 identified by match to protein family HMM PF06164; hypothetical protein 3122304 6146702 EcSMS35_3033 Escherichia coli SMS-3-5 hypothetical protein YP_001745053.1 3121993 R 439855 CDS YP_001745054.1 170681438 6147280 3122343..3123782 1 NC_010498.1 identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase BglA 3123782 bglA 6147280 bglA Escherichia coli SMS-3-5 6-phospho-beta-glucosidase BglA YP_001745054.1 3122343 D 439855 CDS YP_001745055.1 170679779 6145622 complement(3123946..3126819) 1 NC_010498.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3126819 gcvP 6145622 gcvP Escherichia coli SMS-3-5 glycine dehydrogenase YP_001745055.1 3123946 R 439855 CDS YP_001745056.1 170680437 6143938 complement(3126938..3127327) 1 NC_010498.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3127327 gcvH 6143938 gcvH Escherichia coli SMS-3-5 glycine cleavage system protein H YP_001745056.1 3126938 R 439855 CDS YP_001745057.1 170683423 6144606 complement(3127351..3128445) 1 NC_010498.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3128445 gcvT 6144606 gcvT Escherichia coli SMS-3-5 glycine cleavage system aminomethyltransferase T YP_001745057.1 3127351 R 439855 CDS YP_001745058.1 170683999 6142710 complement(3128621..3128749) 1 NC_010498.1 hypothetical protein 3128749 6142710 EcSMS35_3038 Escherichia coli SMS-3-5 hypothetical protein YP_001745058.1 3128621 R 439855 CDS YP_001745059.1 170682333 6143298 3128706..3128819 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3128819 6143298 EcSMS35_3039 Escherichia coli SMS-3-5 hypothetical protein YP_001745059.1 3128706 D 439855 CDS YP_001745060.1 170683096 6146532 complement(3128893..3130095) 1 NC_010498.1 identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM TIGR01988; hypothetical protein 3130095 6146532 EcSMS35_3040 Escherichia coli SMS-3-5 hypothetical protein YP_001745060.1 3128893 R 439855 CDS YP_001745061.1 170680909 6147315 complement(3130118..3131296) 1 NC_010498.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3131296 ubiH 6147315 ubiH Escherichia coli SMS-3-5 2-octaprenyl-6-methoxyphenyl hydroxylase YP_001745061.1 3130118 R 439855 CDS YP_001745062.1 170680916 6145089 complement(3131293..3132618) 1 NC_010498.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3132618 pepP 6145089 pepP Escherichia coli SMS-3-5 proline aminopeptidase P II YP_001745062.1 3131293 R 439855 CDS YP_001745063.1 170681497 6145097 complement(3132644..3133228) 1 NC_010498.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3133228 6145097 EcSMS35_3043 Escherichia coli SMS-3-5 hypothetical protein YP_001745063.1 3132644 R 439855 CDS YP_001745064.1 170681951 6145682 3133390..3133719 1 NC_010498.1 identified by match to protein family HMM PF05164; Z-ring-associated protein 3133719 6145682 EcSMS35_3044 Escherichia coli SMS-3-5 Z-ring-associated protein YP_001745064.1 3133390 D 439855 CDS YP_001745065.1 170683068 6146147 3133965..3134567 1 NC_010498.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; putative ligase 3134567 6146147 EcSMS35_3045 Escherichia coli SMS-3-5 putative ligase YP_001745065.1 3133965 D 439855 CDS YP_001745066.1 170683573 6147285 complement(3134956..3136188) 1 NC_010498.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3136188 serA 6147285 serA Escherichia coli SMS-3-5 D-3-phosphoglycerate dehydrogenase YP_001745066.1 3134956 R 439855 CDS YP_001745067.1 170684222 6142864 complement(3136444..3137103) 1 NC_010498.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3137103 rpiA 6142864 rpiA Escherichia coli SMS-3-5 ribose-5-phosphate isomerase A YP_001745067.1 3136444 R 439855 CDS YP_001745068.1 170680003 6143523 complement(3137159..3138055) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3138055 6143523 EcSMS35_3048 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001745068.1 3137159 R 439855 CDS YP_001745069.1 170680497 6144166 3138156..3138785 1 NC_010498.1 identified by similarity to SP:Q9L867; match to protein family HMM PF02525; azoreductase type 1 family protein 3138785 6144166 EcSMS35_3049 Escherichia coli SMS-3-5 azoreductase type 1 family protein YP_001745069.1 3138156 D 439855 CDS YP_001745070.1 170680314 6144666 3138802..3139062 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 3139062 6144666 EcSMS35_3050 Escherichia coli SMS-3-5 hypothetical protein YP_001745070.1 3138802 D 439855 CDS YP_001745071.1 170680814 6144482 3139124..3140449 1 NC_010498.1 identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; match to protein family HMM PF08022; ferric reductase/oxidoreductase, FAD/NAD binding 3140449 6144482 EcSMS35_3051 Escherichia coli SMS-3-5 ferric reductase/oxidoreductase, FAD/NAD binding YP_001745071.1 3139124 D 439855 CDS YP_001745072.1 170684145 6144990 3140520..3141413 1 NC_010498.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3141413 iciA 6144990 iciA Escherichia coli SMS-3-5 chromosome replication initiation inhibitor protein YP_001745072.1 3140520 D 439855 CDS YP_001745073.1 170683251 6143445 3141616..3143760 1 NC_010498.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3143760 msm 6143445 msm Escherichia coli SMS-3-5 methylmalonyl-CoA mutase YP_001745073.1 3141616 D 439855 CDS YP_001745074.1 170683019 6147474 3143753..3144748 1 NC_010498.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3144748 6147474 EcSMS35_3054 Escherichia coli SMS-3-5 arginine/ornithine transport system ATPase YP_001745074.1 3143753 D 439855 CDS YP_001745075.1 170682071 6147235 3144759..3145544 1 NC_010498.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3145544 6147235 EcSMS35_3055 Escherichia coli SMS-3-5 methylmalonyl-CoA decarboxylase YP_001745075.1 3144759 D 439855 CDS YP_001745076.1 170681655 6146268 3145568..3147046 1 NC_010498.1 identified by match to protein family HMM PF02550; match to protein family HMM TIGR03458; acetyl-CoA hydrolase/transferase 3147046 6146268 EcSMS35_3057 Escherichia coli SMS-3-5 acetyl-CoA hydrolase/transferase YP_001745076.1 3145568 D 439855 CDS YP_001745077.1 170681536 6145841 complement(3147043..3147939) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3147939 6145841 EcSMS35_3056 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001745077.1 3147043 R 439855 CDS YP_001745078.1 170681135 6145721 complement(3148107..3148847) 1 NC_010498.1 identified by match to protein family HMM PF04402; hypothetical protein 3148847 6145721 EcSMS35_3058 Escherichia coli SMS-3-5 hypothetical protein YP_001745078.1 3148107 R 439855 CDS YP_001745079.1 170680655 6145318 complement(3148940..3149575) 1 NC_010498.1 Involved in the export of arginine; arginine exporter protein 3149575 argO 6145318 argO Escherichia coli SMS-3-5 arginine exporter protein YP_001745079.1 3148940 R 439855 CDS YP_001745080.1 170679959 6144830 3149691..3150734 1 NC_010498.1 identified by match to protein family HMM PF03480; solute-binding family 7 protein 3150734 6144830 EcSMS35_3060 Escherichia coli SMS-3-5 solute-binding family 7 protein YP_001745080.1 3149691 D 439855 CDS YP_001745081.1 170682680 6144121 complement(3150776..3151651) 1 NC_010498.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3151651 mscS 6144121 mscS Escherichia coli SMS-3-5 mechanosensitive channel MscS YP_001745081.1 3150776 R 439855 CDS YP_001745082.1 170681392 6146888 complement(3152009..3153088) 1 NC_010498.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3153088 fbaA 6146888 fbaA Escherichia coli SMS-3-5 fructose-bisphosphate aldolase YP_001745082.1 3152009 R 439855 CDS YP_001745083.1 170681168 6145576 complement(3153302..3154465) 1 NC_010498.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3154465 pgk 6145576 pgk Escherichia coli SMS-3-5 phosphoglycerate kinase YP_001745083.1 3153302 R 439855 CDS YP_001745084.1 170679808 6145352 complement(3154515..3155534) 1 NC_010498.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3155534 epd 6145352 epd Escherichia coli SMS-3-5 erythrose 4-phosphate dehydrogenase YP_001745084.1 3154515 R 439855 CDS YP_001745085.1 170680119 6143969 3155906..3156337 1 NC_010498.1 identified by match to protein family HMM PF03479; hypothetical protein 3156337 6143969 EcSMS35_3065 Escherichia coli SMS-3-5 hypothetical protein YP_001745085.1 3155906 D 439855 CDS YP_001745086.1 170684110 6144284 3156360..3156938 1 NC_010498.1 hypothetical protein 3156938 6144284 EcSMS35_3066 Escherichia coli SMS-3-5 hypothetical protein YP_001745086.1 3156360 D 439855 CDS YP_001745087.1 170683038 6143410 3156939..3157646 1 NC_010498.1 hypothetical protein 3157646 6143410 EcSMS35_3067 Escherichia coli SMS-3-5 hypothetical protein YP_001745087.1 3156939 D 439855 CDS YP_001745088.1 170682493 6147254 3157628..3158311 1 NC_010498.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 3158311 6147254 EcSMS35_3068 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001745088.1 3157628 D 439855 CDS YP_001745089.1 170680805 6146692 3158305..3158982 1 NC_010498.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 3158982 6146692 EcSMS35_3070 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001745089.1 3158305 D 439855 CDS YP_001745090.1 170681606 6144981 complement(3158954..3159667) 1 NC_010498.1 putative fructose transport system kinase 3159667 frcK 6144981 frcK Escherichia coli SMS-3-5 putative fructose transport system kinase YP_001745090.1 3158954 R 439855 CDS YP_001745091.1 170679690 6145791 complement(3159664..3160173) 1 NC_010498.1 identified by match to protein family HMM PF05068; putative DNA-binding transcriptional regulator 3160173 6145791 EcSMS35_3071 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001745091.1 3159664 R 439855 CDS YP_001745092.1 170680034 6143848 complement(3160195..3161160) 1 NC_010498.1 identified by match to protein family HMM PF03320; match to protein family HMM TIGR00330; fructose-1,6-bisphosphatase II-like protein 3161160 glpX2 6143848 glpX2 Escherichia coli SMS-3-5 fructose-1,6-bisphosphatase II-like protein YP_001745092.1 3160195 R 439855 CDS YP_001745093.1 170683729 6144197 complement(3161157..3162434) 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; L-sorbose 1-phosphate reductase 3162434 sorE 6144197 sorE Escherichia coli SMS-3-5 L-sorbose 1-phosphate reductase YP_001745093.1 3161157 R 439855 CDS YP_001745094.1 170680302 6143813 complement(3163865..3164308) 1 NC_010498.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA 3164308 cmtB 6143813 cmtB Escherichia coli SMS-3-5 putative mannitol phosphotransferase subunit EIIA YP_001745094.1 3163865 R 439855 CDS YP_001745095.1 170680516 6144470 3164685..3165593 1 NC_010498.1 identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein 3165593 6144470 EcSMS35_3076 Escherichia coli SMS-3-5 SPFH domain-containing protein/band 7 family protein YP_001745095.1 3164685 D 439855 CDS YP_001745096.1 170681853 6144686 complement(3165813..3167804) 1 NC_010498.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3167804 tktA 6144686 tktA Escherichia coli SMS-3-5 transketolase YP_001745096.1 3165813 R 439855 CDS YP_001745097.1 170682269 6146047 3168082..3168840 1 NC_010498.1 identified by match to protein family HMM PF01435; M48B family peptidase 3168840 6146047 EcSMS35_3078 Escherichia coli SMS-3-5 M48B family peptidase YP_001745097.1 3168082 D 439855 CDS YP_001745098.1 170682959 6146468 complement(3168888..3169808) 1 NC_010498.1 catalyzes the formation of putrescine from agmatine; agmatinase 3169808 speB 6146468 speB Escherichia coli SMS-3-5 agmatinase YP_001745098.1 3168888 R 439855 CDS YP_001745099.1 170683310 6147174 complement(3169944..3170675) 1 NC_010498.1 putative lipoprotein 3170675 6147174 EcSMS35_3080 Escherichia coli SMS-3-5 putative lipoprotein YP_001745099.1 3169944 R 439855 CDS YP_001745100.1 170679666 6142594 complement(3170821..3172719) 1 NC_010498.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3172719 speA 6142594 speA Escherichia coli SMS-3-5 arginine decarboxylase YP_001745100.1 3170821 R 439855 CDS YP_001745101.1 170681127 6143824 complement(3172806..3172937) 1 NC_010498.1 hypothetical protein 3172937 6143824 EcSMS35_3082 Escherichia coli SMS-3-5 hypothetical protein YP_001745101.1 3172806 R 439855 CDS YP_001745102.1 170680030 6145310 complement(3173285..3173536) 1 NC_010498.1 identified by similarity to RF:NP_838428.1; hypothetical protein 3173536 6145310 EcSMS35_3083 Escherichia coli SMS-3-5 hypothetical protein YP_001745102.1 3173285 R 439855 CDS YP_001745103.1 170681721 6144193 3173592..3174746 1 NC_010498.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3174746 metK 6144193 metK Escherichia coli SMS-3-5 S-adenosylmethionine synthetase YP_001745103.1 3173592 D 439855 CDS YP_001745104.1 170681091 6145909 3175182..3176576 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879; galactose-proton symporter 3176576 galP 6145909 galP Escherichia coli SMS-3-5 galactose-proton symporter YP_001745104.1 3175182 D 439855 CDS YP_001745105.1 170682825 6145273 3176653..3177150 1 NC_010498.1 identified by match to protein family HMM PF03926; hypothetical protein 3177150 sprT 6145273 sprT Escherichia coli SMS-3-5 hypothetical protein YP_001745105.1 3176653 D 439855 CDS YP_001745106.1 170682683 6147036 3177245..3177952 1 NC_010498.1 identified by match to protein family HMM PF04231; endonuclease I 3177952 endA 6147036 endA Escherichia coli SMS-3-5 endonuclease I YP_001745106.1 3177245 D 439855 CDS YP_001745107.1 170682172 6146891 3178032..3178763 1 NC_010498.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3178763 rsmE 6146891 rsmE Escherichia coli SMS-3-5 16S ribosomal RNA methyltransferase RsmE YP_001745107.1 3178032 D 439855 CDS YP_001745108.1 170683849 6146371 3178776..3179726 1 NC_010498.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3179726 gshB 6146371 gshB Escherichia coli SMS-3-5 glutathione synthetase YP_001745108.1 3178776 D 439855 CDS YP_001745109.1 170680665 6143143 3179835..3180398 1 NC_010498.1 identified by match to protein family HMM PF02622; hypothetical protein 3180398 6143143 EcSMS35_3090 Escherichia coli SMS-3-5 hypothetical protein YP_001745109.1 3179835 D 439855 CDS YP_001745110.1 170681746 6144840 3180398..3180814 1 NC_010498.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3180814 6144840 EcSMS35_3091 Escherichia coli SMS-3-5 Holliday junction resolvase-like protein YP_001745110.1 3180398 D 439855 CDS YP_001745111.1 170680393 6145936 complement(3180993..3182018) 1 NC_010498.1 identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420; twitching motility family protein 3182018 6145936 EcSMS35_3092 Escherichia coli SMS-3-5 twitching motility family protein YP_001745111.1 3180993 R 439855 CDS YP_001745112.1 170683383 6144562 3181991..3182695 1 NC_010498.1 identified by match to protein family HMM PF01168; match to protein family HMM TIGR00044; alanine racemase 3182695 6144562 EcSMS35_3093 Escherichia coli SMS-3-5 alanine racemase YP_001745112.1 3181991 D 439855 CDS YP_001745113.1 170683909 6142669 3182713..3183279 1 NC_010498.1 identified by match to protein family HMM PF02325; YGGT family protein 3183279 6142669 EcSMS35_3094 Escherichia coli SMS-3-5 YGGT family protein YP_001745113.1 3182713 D 439855 CDS YP_001745114.1 170681809 6143205 3183276..3183566 1 NC_010498.1 yggU; identified by similarity to SP:Q83JS1; match to protein family HMM PF02594; match to protein family HMM TIGR00251; hypothetical protein 3183566 6143205 EcSMS35_3095 Escherichia coli SMS-3-5 hypothetical protein YP_001745114.1 3183276 D 439855 CDS YP_001745115.1 170679994 6146002 3183574..3184167 1 NC_010498.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3184167 rdgB 6146002 rdgB Escherichia coli SMS-3-5 putative deoxyribonucleotide triphosphate pyrophosphatase YP_001745115.1 3183574 D 439855 CDS YP_001745116.1 170681312 6144156 3184160..3185296 1 NC_010498.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3185296 6144156 EcSMS35_3097 Escherichia coli SMS-3-5 coproporphyrinogen III oxidase YP_001745116.1 3184160 D 439855 CDS YP_001745117.1 170681863 6145496 complement(3185365..3186372) 1 NC_010498.1 identified by match to protein family HMM PF06717; hypothetical protein 3186372 6145496 EcSMS35_3098 Escherichia coli SMS-3-5 hypothetical protein YP_001745117.1 3185365 R 439855 CDS YP_001745118.1 170682068 6146057 complement(3186489..3187535) 1 NC_010498.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3187535 ansB 6146057 ansB Escherichia coli SMS-3-5 L-asparaginase II YP_001745118.1 3186489 R 439855 CDS YP_001745119.1 170682570 6146265 complement(3187711..3188430) 1 NC_010498.1 hypothetical protein 3188430 6146265 EcSMS35_3100 Escherichia coli SMS-3-5 hypothetical protein YP_001745119.1 3187711 R 439855 CDS YP_001745120.1 170679978 6146775 complement(3188451..3188591) 1 NC_010498.1 hypothetical protein 3188591 6146775 EcSMS35_3101 Escherichia coli SMS-3-5 hypothetical protein YP_001745120.1 3188451 R 439855 CDS YP_001745121.1 170682631 6144140 complement(3188614..3188940) 1 NC_010498.1 identified by match to protein family HMM PF04320; hypothetical protein 3188940 6144140 EcSMS35_3102 Escherichia coli SMS-3-5 hypothetical protein YP_001745121.1 3188614 R 439855 CDS YP_001745122.1 170682679 6146837 complement(3188940..3189659) 1 NC_010498.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3189659 trmB 6146837 trmB Escherichia coli SMS-3-5 tRNA (guanine-N(7)-)-methyltransferase YP_001745122.1 3188940 R 439855 CDS YP_001745123.1 170682894 6146887 3189820..3190872 1 NC_010498.1 identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; adenine DNA glycosylase 3190872 mutY 6146887 mutY Escherichia coli SMS-3-5 adenine DNA glycosylase YP_001745123.1 3189820 D 439855 CDS YP_001745124.1 170683828 6147107 3190900..3191175 1 NC_010498.1 identified by match to protein family HMM PF04362; hypothetical protein 3191175 6147107 EcSMS35_3105 Escherichia coli SMS-3-5 hypothetical protein YP_001745124.1 3190900 D 439855 CDS YP_001745125.1 170683301 6143122 3191239..3192318 1 NC_010498.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3192318 mltC 6143122 mltC Escherichia coli SMS-3-5 murein transglycosylase C YP_001745125.1 3191239 D 439855 CDS YP_001745126.1 170680733 6147527 complement(3192324..3192458) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3192458 6147527 EcSMS35_3107 Escherichia coli SMS-3-5 hypothetical protein YP_001745126.1 3192324 R 439855 CDS YP_001745127.1 170679662 6144908 3192520..3193776 1 NC_010498.1 identified by similarity to SP:P0AFF5; match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; nucleoside permease NupG 3193776 nupG 6144908 nupG Escherichia coli SMS-3-5 nucleoside permease NupG YP_001745127.1 3192520 D 439855 CDS YP_001745128.1 170681617 6143820 complement(3193823..3195958) 1 NC_010498.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; ornithine decarboxylase 3195958 speC 6143820 speC Escherichia coli SMS-3-5 ornithine decarboxylase YP_001745128.1 3193823 R 439855 CDS YP_001745129.1 170679820 6143632 3197411..3198595 1 NC_010498.1 identified by match to protein family HMM PF00589; site-specific recombinase, phage integrase family protein 3198595 6143632 EcSMS35_3112 Escherichia coli SMS-3-5 site-specific recombinase, phage integrase family protein YP_001745129.1 3197411 D 439855 CDS YP_001745130.1 170682779 6143982 3198745..3199755 1 NC_010498.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator RafR 3199755 rafR 6143982 rafR Escherichia coli SMS-3-5 HTH-type transcriptional regulator RafR YP_001745130.1 3198745 D 439855 CDS YP_001745131.1 170682126 6146988 3199851..3201977 1 NC_010498.1 identified by match to protein family HMM PF02065; alpha-galactosidase 3201977 rafA 6146988 rafA Escherichia coli SMS-3-5 alpha-galactosidase YP_001745131.1 3199851 D 439855 CDS YP_001745132.1 170683854 6146325 3202040..3203317 1 NC_010498.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 3203317 lacY 6146325 lacY Escherichia coli SMS-3-5 galactoside permease YP_001745132.1 3202040 D 439855 CDS YP_001745133.1 170683153 6143148 3203317..3204747 1 NC_010498.1 identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; raffinose invertase 3204747 rafD 6143148 rafD Escherichia coli SMS-3-5 raffinose invertase YP_001745133.1 3203317 D 439855 CDS YP_001745134.1 170680709 6147373 3204942..3206336 1 NC_010498.1 identified by similarity to GB:AAB71432.1; glycoporin RafY 3206336 rafY1 6147373 rafY1 Escherichia coli SMS-3-5 glycoporin RafY YP_001745134.1 3204942 D 439855 CDS YP_001745135.1 170683732 6144884 complement(3206914..3207357) 1 NC_010498.1 identified by similarity to SP:P19777; IS2 transposase orfB 3207357 6144884 EcSMS35_3118 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001745135.1 3206914 R 439855 CDS YP_001745136.1 170683540 6143024 complement(3207276..3207551) 1 NC_010498.1 identified by match to protein family HMM PF03811; IS1 transposase orfA 3207551 6143024 EcSMS35_3119 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001745136.1 3207276 R 439855 CDS YP_001745137.1 170680853 6142830 complement(3207580..3207804) 1 NC_010498.1 hypothetical protein 3207804 6142830 EcSMS35_3120 Escherichia coli SMS-3-5 hypothetical protein YP_001745137.1 3207580 R 439855 CDS YP_001745138.1 170682342 6146851 3210660..3211337 1 NC_010498.1 identified by match to protein family HMM PF01527; IS66 family transposase orfA 3211337 6146851 EcSMS35_3124 Escherichia coli SMS-3-5 IS66 family transposase orfA YP_001745138.1 3210660 D 439855 CDS YP_001745139.1 170681419 6146541 complement(3211418..3211597) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3211597 6146541 EcSMS35_3125 Escherichia coli SMS-3-5 hypothetical protein YP_001745139.1 3211418 R 439855 CDS YP_001745140.1 170683550 6145603 3211704..3213278 1 NC_010498.1 identified by match to protein family HMM PF03050; IS66 family transposase orfB 3213278 6145603 EcSMS35_3126 Escherichia coli SMS-3-5 IS66 family transposase orfB YP_001745140.1 3211704 D 439855 CDS YP_001745141.1 170680348 6142840 complement(3213444..3213680) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3213680 6142840 EcSMS35_3127 Escherichia coli SMS-3-5 hypothetical protein YP_001745141.1 3213444 R 439855 CDS YP_001745142.1 170684240 6144516 complement(3214175..3216262) 1 NC_010498.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 3216262 6144516 EcSMS35_3128 Escherichia coli SMS-3-5 bifunctional enterobactin receptor/adhesin protein YP_001745142.1 3214175 R 439855 CDS YP_001745143.1 170683144 6143541 3216575..3216859 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3216859 6143541 EcSMS35_3129 Escherichia coli SMS-3-5 hypothetical protein YP_001745143.1 3216575 D 439855 CDS YP_001745144.1 170683670 6147364 3217235..3217588 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3217588 6147364 EcSMS35_3130 Escherichia coli SMS-3-5 hypothetical protein YP_001745144.1 3217235 D 439855 CDS YP_001745145.1 170681851 6142962 complement(3218016..3219047) 1 NC_010498.1 identified by similarity to SP:P16943; IS630 transposase 3219047 6142962 EcSMS35_3131 Escherichia coli SMS-3-5 IS630 transposase YP_001745145.1 3218016 R 439855 CDS YP_001745146.1 170681183 6146045 complement(3219190..3219366) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3219366 6146045 EcSMS35_3132 Escherichia coli SMS-3-5 hypothetical protein YP_001745146.1 3219190 R 439855 CDS YP_001745147.1 170680285 6143245 complement(3223179..3223529) 1 NC_010498.1 identified by match to protein family HMM PF05717; IS66 family transposase orfB 3223529 6143245 EcSMS35_3136 Escherichia coli SMS-3-5 IS66 family transposase orfB YP_001745147.1 3223179 R 439855 CDS YP_001745148.1 170681295 6144452 complement(3223526..3223951) 1 NC_010498.1 identified by match to protein family HMM PF01527; IS66 family transposase orfA 3223951 6144452 EcSMS35_3137 Escherichia coli SMS-3-5 IS66 family transposase orfA YP_001745148.1 3223526 R 439855 CDS YP_001745149.1 170683287 6144546 complement(3227446..3228705) 1 NC_010498.1 identified by similarity to SP:P63883; match to protein family HMM PF01520; N-acetylmuramoyl-L-alanine amidase AmiC 3228705 amiC2 6144546 amiC2 Escherichia coli SMS-3-5 N-acetylmuramoyl-L-alanine amidase AmiC YP_001745149.1 3227446 R 439855 CDS YP_001745150.1 170682595 6147513 complement(3229572..3229997) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3229997 6147513 EcSMS35_3141 Escherichia coli SMS-3-5 hypothetical protein YP_001745150.1 3229572 R 439855 CDS YP_001745151.1 170681926 6143548 complement(3230570..3231313) 1 NC_010498.1 identified by match to protein family HMM PF01695; IS21 transposase orfB 3231313 6143548 EcSMS35_3143 Escherichia coli SMS-3-5 IS21 transposase orfB YP_001745151.1 3230570 R 439855 CDS YP_001745152.1 170680910 6146122 complement(3231313..3232485) 1 NC_010498.1 identified by match to protein family HMM PF00665; IS2 transposase orfA 3232485 6146122 EcSMS35_3144 Escherichia coli SMS-3-5 IS2 transposase orfA YP_001745152.1 3231313 R 439855 CDS YP_001745153.1 170683482 6146769 complement(3236889..3237533) 1 NC_010498.1 identified by similarity to GB:AAM53134.1; match to protein family HMM PF02195; immunoglobulin-binding regulator B 3237533 ibrB 6146769 ibrB Escherichia coli SMS-3-5 immunoglobulin-binding regulator B YP_001745153.1 3236889 R 439855 CDS YP_001745154.1 170679850 6142771 complement(3237518..3238744) 1 NC_010498.1 identified by similarity to GB:AAM53133.1; match to protein family HMM PF01507; immunoglobulin-binding regulator A 3238744 ibrA 6142771 ibrA Escherichia coli SMS-3-5 immunoglobulin-binding regulator A YP_001745154.1 3237518 R 439855 CDS YP_001745155.1 170682946 6146694 complement(3240031..3240180) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3240180 6146694 EcSMS35_3155 Escherichia coli SMS-3-5 hypothetical protein YP_001745155.1 3240031 R 439855 CDS YP_001745156.1 170681351 6147161 3240501..3240800 1 NC_010498.1 identified by match to protein family HMM PF01527; ISEc16 transposase orfA 3240800 6147161 EcSMS35_3156 Escherichia coli SMS-3-5 ISEc16 transposase orfA YP_001745156.1 3240501 D 439855 CDS YP_001745157.1 170682386 6145893 3244161..3244352 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3244352 6145893 EcSMS35_3161 Escherichia coli SMS-3-5 hypothetical protein YP_001745157.1 3244161 D 439855 CDS YP_001745158.1 170680430 6146585 3245598..3245822 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3245822 6146585 EcSMS35_3162 Escherichia coli SMS-3-5 hypothetical protein YP_001745158.1 3245598 D 439855 CDS YP_001745159.1 170680640 6144599 complement(3245951..3246475) 1 NC_010498.1 identified by similarity to SP:P53636; match to protein family HMM PF00080; superoxide dismutase (Cu-Zn) 3246475 sodC_2 6144599 sodC_2 Escherichia coli SMS-3-5 superoxide dismutase (Cu-Zn) YP_001745159.1 3245951 R 439855 CDS YP_001745160.1 170681064 6144815 3246929..3247294 1 NC_010498.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3247294 6144815 EcSMS35_3164 Escherichia coli SMS-3-5 insertion sequence 2 OrfA protein YP_001745160.1 3246929 D 439855 CDS YP_001745161.1 170683785 6145246 3247252..3248157 1 NC_010498.1 identified by match to protein family HMM PF00665; IS2 transposase orfB 3248157 6145246 EcSMS35_3165 Escherichia coli SMS-3-5 IS2 transposase orfB YP_001745161.1 3247252 D 439855 CDS YP_001745162.1 170680040 6143077 3248142..3248258 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3248258 6143077 EcSMS35_3166 Escherichia coli SMS-3-5 hypothetical protein YP_001745162.1 3248142 D 439855 CDS YP_001745163.1 170681562 6144203 complement(3248278..3248430) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3248430 6144203 EcSMS35_3167 Escherichia coli SMS-3-5 hypothetical protein YP_001745163.1 3248278 R 439855 CDS YP_001745164.1 170680094 6144399 3251173..3252087 1 NC_010498.1 identified by similarity to GB:AAT11264.1; match to protein family HMM PF01297; iron/manganese transport system periplasmic binding protein SitA 3252087 sitA_2 6144399 sitA_2 Escherichia coli SMS-3-5 iron/manganese transport system periplasmic binding protein SitA YP_001745164.1 3251173 D 439855 CDS YP_001745165.1 170684230 6144258 3252087..3252914 1 NC_010498.1 identified by similarity to GB:AAT11265.1; match to protein family HMM PF00005; iron/manganese transport system inner membrane protein SitB 3252914 sitB_2 6144258 sitB_2 Escherichia coli SMS-3-5 iron/manganese transport system inner membrane protein SitB YP_001745165.1 3252087 D 439855 CDS YP_001745166.1 170683483 6143531 3252911..3253768 1 NC_010498.1 identified by similarity to GB:AAT11266.1; match to protein family HMM PF00950; match to protein family HMM PF01032; iron/manganese transport system inner membrane protein SitC 3253768 sitC_2 6143531 sitC_2 Escherichia coli SMS-3-5 iron/manganese transport system inner membrane protein SitC YP_001745166.1 3252911 D 439855 CDS YP_001745167.1 170682856 6142772 3253765..3254643 1 NC_010498.1 identified by similarity to GB:AAT11267.1; match to protein family HMM PF00950; iron/manganese transport system membrane protein SitD 3254643 sitD_2 6142772 sitD_2 Escherichia coli SMS-3-5 iron/manganese transport system membrane protein SitD YP_001745167.1 3253765 D 439855 CDS YP_001745168.1 170680936 6143094 complement(3257233..3259434) 1 NC_010498.1 identified by similarity to SP:P14542; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; ferric aerobactin receptor IutA 3259434 iutA 6143094 iutA Escherichia coli SMS-3-5 ferric aerobactin receptor IutA YP_001745168.1 3257233 R 439855 CDS YP_001745169.1 170682870 6145117 complement(3259516..3260793) 1 NC_010498.1 identified by similarity to SP:P11295; L-lysine 6-monooxygenase IucD 3260793 iucD 6145117 iucD Escherichia coli SMS-3-5 L-lysine 6-monooxygenase IucD YP_001745169.1 3259516 R 439855 CDS YP_001745170.1 170679922 6147083 complement(3260790..3262532) 1 NC_010498.1 identified by similarity to SP:Q47318; match to protein family HMM PF04183; aerobactin siderophore biosynthesis protein IucC 3262532 iucC 6147083 iucC Escherichia coli SMS-3-5 aerobactin siderophore biosynthesis protein IucC YP_001745170.1 3260790 R 439855 CDS YP_001745171.1 170681805 6144084 complement(3262532..3263479) 1 NC_010498.1 identified by similarity to SP:Q47317; aerobactin siderophore biosynthesis protein IucB 3263479 iucB 6144084 iucB Escherichia coli SMS-3-5 aerobactin siderophore biosynthesis protein IucB YP_001745171.1 3262532 R 439855 CDS YP_001745172.1 170683655 6145998 complement(3263480..3265204) 1 NC_010498.1 identified by similarity to SP:Q47316; match to protein family HMM PF04183; aerobactin siderophore biosynthesis protein IucA 3265204 iucA 6145998 iucA Escherichia coli SMS-3-5 aerobactin siderophore biosynthesis protein IucA YP_001745172.1 3263480 R 439855 CDS YP_001745173.1 170683143 6142947 3265340..3266533 1 NC_010498.1 identified by match to protein family HMM PF07690; transport protein ShiF 3266533 shiF 6142947 shiF Escherichia coli SMS-3-5 transport protein ShiF YP_001745173.1 3265340 D 439855 CDS YP_001745174.1 170681895 6146755 complement(3270859..3271968) 1 NC_010498.1 identified by match to protein family HMM PF03895; match to protein family HMM PF05662; match to protein family HMM TIGR01409; putative immunoglobuling-binding protein 3271968 6146755 EcSMS35_3187 Escherichia coli SMS-3-5 putative immunoglobuling-binding protein YP_001745174.1 3270859 R 439855 CDS YP_001745175.1 170680378 6146090 complement(3271994..3272143) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3272143 6146090 EcSMS35_3188 Escherichia coli SMS-3-5 hypothetical protein YP_001745175.1 3271994 R 439855 CDS YP_001745176.1 170680471 6144547 complement(3272612..3272725) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3272725 6144547 EcSMS35_3189 Escherichia coli SMS-3-5 hypothetical protein YP_001745176.1 3272612 R 439855 CDS YP_001745177.1 170683846 6144640 3272848..3272967 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3272967 6144640 EcSMS35_3190 Escherichia coli SMS-3-5 hypothetical protein YP_001745177.1 3272848 D 439855 CDS YP_001745178.1 170682931 6145945 complement(3275023..3275775) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3275775 6145945 EcSMS35_3195 Escherichia coli SMS-3-5 hypothetical protein YP_001745178.1 3275023 R 439855 CDS YP_001745179.1 170680277 6147145 complement(3275772..3276008) 1 NC_010498.1 identified by match to protein family HMM PF05930; AlpA family transcriptional regulator 3276008 6147145 EcSMS35_3196 Escherichia coli SMS-3-5 AlpA family transcriptional regulator YP_001745179.1 3275772 R 439855 CDS YP_001745180.1 170684254 6144444 complement(3276077..3276649) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3276649 6144444 EcSMS35_3197 Escherichia coli SMS-3-5 hypothetical protein YP_001745180.1 3276077 R 439855 CDS YP_001745181.1 170680895 6143556 complement(3277010..3277741) 1 NC_010498.1 hypothetical protein 3277741 6143556 EcSMS35_3198 Escherichia coli SMS-3-5 hypothetical protein YP_001745181.1 3277010 R 439855 CDS YP_001745182.1 170680288 6145073 complement(3278077..3278235) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3278235 6145073 EcSMS35_3199 Escherichia coli SMS-3-5 hypothetical protein YP_001745182.1 3278077 R 439855 CDS YP_001745183.1 170682219 6144456 complement(3278337..3278456) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3278456 6144456 EcSMS35_3200 Escherichia coli SMS-3-5 hypothetical protein YP_001745183.1 3278337 R 439855 CDS YP_001745184.1 170681543 6146418 complement(3279260..3280390) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3280390 6146418 EcSMS35_3201 Escherichia coli SMS-3-5 hypothetical protein YP_001745184.1 3279260 R 439855 CDS YP_001745185.1 170683026 6145728 3280575..3281459 1 NC_010498.1 identified by match to protein family HMM PF01926; putative GTPase 3281459 6145728 EcSMS35_3202 Escherichia coli SMS-3-5 putative GTPase YP_001745185.1 3280575 D 439855 CDS YP_001745186.1 170682482 6147242 3281478..3281633 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3281633 6147242 EcSMS35_3203 Escherichia coli SMS-3-5 hypothetical protein YP_001745186.1 3281478 D 439855 CDS YP_001745187.1 170684082 6146681 3281662..3282342 1 NC_010498.1 identified by match to protein family HMM PF08279; hypothetical protein 3282342 6146681 EcSMS35_3204 Escherichia coli SMS-3-5 hypothetical protein YP_001745187.1 3281662 D 439855 CDS YP_001745188.1 170680435 6143382 3282385..3283167 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3283167 6143382 EcSMS35_3205 Escherichia coli SMS-3-5 hypothetical protein YP_001745188.1 3282385 D 439855 CDS YP_001745189.1 170681575 6144604 3283173..3283406 1 NC_010498.1 identified by match to protein family HMM PF06006; hypothetical protein 3283406 6144604 EcSMS35_3206 Escherichia coli SMS-3-5 hypothetical protein YP_001745189.1 3283173 D 439855 CDS YP_001745190.1 170681686 6145760 3283496..3284314 1 NC_010498.1 identified by match to protein family HMM PF06067; hypothetical protein 3284314 6145760 EcSMS35_3207 Escherichia coli SMS-3-5 hypothetical protein YP_001745190.1 3283496 D 439855 CDS YP_001745191.1 170683532 6145872 3284396..3284875 1 NC_010498.1 identified by match to protein family HMM PF03230; antirestriction protein 3284875 6145872 EcSMS35_3208 Escherichia coli SMS-3-5 antirestriction protein YP_001745191.1 3284396 D 439855 CDS YP_001745192.1 170683005 6142822 3284891..3285367 1 NC_010498.1 identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 3285367 6142822 EcSMS35_3209 Escherichia coli SMS-3-5 RadC family DNA repair protein YP_001745192.1 3284891 D 439855 CDS YP_001745193.1 170684170 6147221 3285430..3285651 1 NC_010498.1 identified by match to protein family HMM PF06174; hypothetical protein 3285651 6147221 EcSMS35_3210 Escherichia coli SMS-3-5 hypothetical protein YP_001745193.1 3285430 D 439855 CDS YP_001745194.1 170683172 6143471 3285851..3286105 1 NC_010498.1 identified by similarity to SP:P76364; match to protein family HMM PF06154; putative antitoxin module of toxin-antitoxin system 3286105 6143471 EcSMS35_3211 Escherichia coli SMS-3-5 putative antitoxin module of toxin-antitoxin system YP_001745194.1 3285851 D 439855 CDS YP_001745195.1 170680300 6147392 3286152..3286529 1 NC_010498.1 identified by match to protein family HMM PF06755; hypothetical protein 3286529 6147392 EcSMS35_3212 Escherichia coli SMS-3-5 hypothetical protein YP_001745195.1 3286152 D 439855 CDS YP_001745196.1 170679625 6144468 3286526..3287014 1 NC_010498.1 hypothetical protein 3287014 6144468 EcSMS35_3213 Escherichia coli SMS-3-5 hypothetical protein YP_001745196.1 3286526 D 439855 CDS YP_001745197.1 170683784 6143782 3287026..3287223 1 NC_010498.1 identified by match to protein family HMM PF06117; hypothetical protein 3287223 6143782 EcSMS35_3214 Escherichia coli SMS-3-5 hypothetical protein YP_001745197.1 3287026 D 439855 CDS YP_001745198.1 170682684 6143076 3287308..3288174 1 NC_010498.1 hypothetical protein 3288174 6143076 EcSMS35_3215 Escherichia coli SMS-3-5 hypothetical protein YP_001745198.1 3287308 D 439855 CDS YP_001745199.1 170683311 6146892 3288246..3288509 1 NC_010498.1 identified by match to protein family HMM PF03693; match to protein family HMM TIGR02606; CC2985 family addiction module antidote protein 3288509 6146892 EcSMS35_3216 Escherichia coli SMS-3-5 CC2985 family addiction module antidote protein YP_001745199.1 3288246 D 439855 CDS YP_001745200.1 170683829 6142596 3289323..3289478 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3289478 6142596 EcSMS35_3217 Escherichia coli SMS-3-5 hypothetical protein YP_001745200.1 3289323 D 439855 CDS YP_001745201.1 170681353 6143123 complement(3289646..3289768) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3289768 6143123 EcSMS35_3218 Escherichia coli SMS-3-5 hypothetical protein YP_001745201.1 3289646 R 439855 CDS YP_001745202.1 170680699 6145537 3290253..3291272 1 NC_010498.1 identified by similarity to SP:Q47334; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393; polysialic acid capsule expression protein KpsF 3291272 kpsF 6145537 kpsF Escherichia coli SMS-3-5 polysialic acid capsule expression protein KpsF YP_001745202.1 3290253 D 439855 CDS YP_001745203.1 170680931 6144874 3291344..3292492 1 NC_010498.1 identified by similarity to SP:P42501; match to protein family HMM TIGR01010; polysialic acid capsule export inner-membrane protein KpsE 3292492 kpsE 6144874 kpsE Escherichia coli SMS-3-5 polysialic acid capsule export inner-membrane protein KpsE YP_001745203.1 3291344 D 439855 CDS YP_001745204.1 170681559 6145112 3292516..3294192 1 NC_010498.1 identified by similarity to SP:Q03961; match to protein family HMM PF02563; polysialic acid capsule transport protein KpsD 3294192 kpsD 6145112 kpsD Escherichia coli SMS-3-5 polysialic acid capsule transport protein KpsD YP_001745204.1 3292516 D 439855 CDS YP_001745205.1 170680703 6145744 3294202..3294942 1 NC_010498.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3294942 kpsU 6145744 kpsU Escherichia coli SMS-3-5 3-deoxy-manno-octulosonate cytidylyltransferase YP_001745205.1 3294202 D 439855 CDS YP_001745206.1 170680172 6144878 3294939..3296972 1 NC_010498.1 identified by similarity to SP:P42217; match to protein family HMM PF05159; polysialic acid capsule polysaccharide export protein KpsC 3296972 kpsC 6144878 kpsC Escherichia coli SMS-3-5 polysialic acid capsule polysaccharide export protein KpsC YP_001745206.1 3294939 D 439855 CDS YP_001745207.1 170680977 6144338 3296995..3298200 1 NC_010498.1 identified by similarity to SP:P42218; match to protein family HMM PF05159; polysialic acid capsule biosynthesis protein KpsS 3298200 kpsS 6144338 kpsS Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis protein KpsS YP_001745207.1 3296995 D 439855 CDS YP_001745208.1 170681953 6146089 complement(3299836..3301065) 1 NC_010498.1 identified by similarity to GB:AAA24213.1; match to protein family HMM PF07388; polysialic acid capsule biosynthesis polysialyltransferase NeuS 3301065 neuS 6146089 neuS Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis polysialyltransferase NeuS YP_001745208.1 3299836 R 439855 CDS YP_001745209.1 170682958 6146149 complement(3301055..3302230) 1 NC_010498.1 identified by similarity to GB:AAY17379.1; polysialic acid capsule biosynthesis protein NeuE 3302230 neuE 6146149 neuE Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis protein NeuE YP_001745209.1 3301055 R 439855 CDS YP_001745210.1 170683594 6147173 complement(3302196..3303371) 1 NC_010498.1 identified by similarity to SP:Q47400; match to protein family HMM PF02350; polysialic acid capsule biosynthesis protein NeuC 3303371 neuC 6147173 neuC Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis protein NeuC YP_001745210.1 3302196 R 439855 CDS YP_001745211.1 170683470 6142885 complement(3303368..3304624) 1 NC_010498.1 identified by similarity to SP:P13266; match to protein family HMM PF02348; polysialic acid capsule biosynthesis N-acylneuraminate cytidylyltransferase NeuA 3304624 neuA 6142885 neuA Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis N-acylneuraminate cytidylyltransferase NeuA YP_001745211.1 3303368 R 439855 CDS YP_001745212.1 170684121 6142759 complement(3304624..3305664) 1 NC_010498.1 identified by similarity to GB:AAC43302.1; match to protein family HMM PF03102; match to protein family HMM PF08666; polysialic acid capsule biosynthesis sialic acid synthase NeuB 3305664 neuB 6142759 neuB Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis sialic acid synthase NeuB YP_001745212.1 3304624 R 439855 CDS YP_001745213.1 170679748 6143421 complement(3305661..3306284) 1 NC_010498.1 identified by similarity to GB:AAC43301.1; polysialic acid capsule biosynthesis protein NeuD 3306284 neuD 6143421 neuD Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis protein NeuD YP_001745213.1 3305661 R 439855 CDS YP_001745214.1 170680342 6143906 complement(3306334..3306993) 1 NC_010498.1 identified by similarity to SP:P23888; match to protein family HMM PF00005; polysialic acid capsule biosynthesis transport protein KpsT 3306993 kpsT 6143906 kpsT Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis transport protein KpsT YP_001745214.1 3306334 R 439855 CDS YP_001745215.1 170681020 6144510 complement(3306990..3307766) 1 NC_010498.1 identified by similarity to SP:P23889; match to protein family HMM PF01061; polysialic acid capsule biosynthesis transport protein KpsM 3307766 kpsM 6144510 kpsM Escherichia coli SMS-3-5 polysialic acid capsule biosynthesis transport protein KpsM YP_001745215.1 3306990 R 439855 CDS YP_001745216.1 170682393 6145201 complement(3308800..3309999) 1 NC_010498.1 identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766; IS200 transposase orfB 3309999 6145201 EcSMS35_3236 Escherichia coli SMS-3-5 IS200 transposase orfB YP_001745216.1 3308800 R 439855 CDS YP_001745217.1 170683194 6146592 3310058..3310462 1 NC_010498.1 identified by match to protein family HMM PF01797; IS200 transposase orfA 3310462 6146592 EcSMS35_3237 Escherichia coli SMS-3-5 IS200 transposase orfA YP_001745217.1 3310058 D 439855 CDS YP_001745218.1 170682883 6147414 complement(3310702..3311238) 1 NC_010498.1 identified by similarity to SP:Q46832; match to protein family HMM PF04612; putative general secretion pathway protein YghD 3311238 gspM 6147414 gspM Escherichia coli SMS-3-5 putative general secretion pathway protein YghD YP_001745218.1 3310702 R 439855 CDS YP_001745219.1 170683391 6147096 complement(3311240..3312418) 1 NC_010498.1 similar to general secretory pathway protein L; GspL-like protein 3312418 gspL 6147096 gspL Escherichia coli SMS-3-5 GspL-like protein YP_001745219.1 3311240 R 439855 CDS YP_001745220.1 170684190 6142677 complement(3312415..3313392) 1 NC_010498.1 identified by similarity to GB:AAL10700.1; match to protein family HMM PF03934; general secretion pathway protein GspK 3313392 gspK 6142677 gspK Escherichia coli SMS-3-5 general secretion pathway protein GspK YP_001745220.1 3312415 R 439855 CDS YP_001745221.1 170679969 6143491 complement(3313392..3313997) 1 NC_010498.1 identified by similarity to GB:AAL60190.1; match to protein family HMM TIGR01711; general secretion pathway protein GspJ 3313997 gspJ 6143491 gspJ Escherichia coli SMS-3-5 general secretion pathway protein GspJ YP_001745221.1 3313392 R 439855 CDS YP_001745222.1 170679735 6144131 complement(3313994..3314365) 1 NC_010498.1 identified by similarity to GB:AAL60189.1; match to protein family HMM PF02501; match to protein family HMM PF07963; match to protein family HMM TIGR01707; match to protein family HMM TIGR02532; general secretion pathway protein GspI 3314365 gspI 6144131 gspI Escherichia coli SMS-3-5 general secretion pathway protein GspI YP_001745222.1 3313994 R 439855 CDS YP_001745223.1 170681274 6143893 complement(3314362..3314925) 1 NC_010498.1 identified by similarity to GB:AAL60188.1; match to protein family HMM PF07963; match to protein family HMM TIGR02532; general secretion pathway protein GspH 3314925 gspH 6143893 gspH Escherichia coli SMS-3-5 general secretion pathway protein GspH YP_001745223.1 3314362 R 439855 CDS YP_001745224.1 170681001 6145458 complement(3314929..3315384) 1 NC_010498.1 identified by similarity to GB:AAL60187.1; match to protein family HMM PF07963; match to protein family HMM PF08334; match to protein family HMM TIGR01710; match to protein family HMM TIGR02532; general secretion pathway protein GspG 3315384 gspG 6145458 gspG Escherichia coli SMS-3-5 general secretion pathway protein GspG YP_001745224.1 3314929 R 439855 CDS YP_001745225.1 170681469 6145182 complement(3315401..3316624) 1 NC_010498.1 identified by similarity to GB:AAL60186.1; match to protein family HMM PF00482; match to protein family HMM TIGR02120; general secretion pathway protein GspF 3316624 gspF 6145182 gspF Escherichia coli SMS-3-5 general secretion pathway protein GspF YP_001745225.1 3315401 R 439855 CDS YP_001745226.1 170683342 6145654 complement(3316624..3318117) 1 NC_010498.1 identified by similarity to GB:AAL60185.1; match to protein family HMM PF00437; match to protein family HMM TIGR02533; general secretory pathway protein GspE 3318117 gspE 6145654 gspE Escherichia coli SMS-3-5 general secretory pathway protein GspE YP_001745226.1 3316624 R 439855 CDS YP_001745227.1 170681179 6142627 complement(3318117..3320177) 1 NC_010498.1 identified by similarity to GB:AAL60184.1; match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM TIGR02517; general secretion pathway protein GspD 3320177 gspD 6142627 gspD Escherichia coli SMS-3-5 general secretion pathway protein GspD YP_001745227.1 3318117 R 439855 CDS YP_001745228.1 170681120 6145363 complement(3320207..3321166) 1 NC_010498.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC 3321166 gspC 6145363 gspC Escherichia coli SMS-3-5 putative type II secretion protein GspC YP_001745228.1 3320207 R 439855 CDS YP_001745229.1 170680581 6145303 complement(3321184..3321594) 1 NC_010498.1 putative lipoprotein 3321594 6145303 EcSMS35_3249 Escherichia coli SMS-3-5 putative lipoprotein YP_001745229.1 3321184 R 439855 CDS YP_001745230.1 170680076 6144751 complement(3321660..3322469) 1 NC_010498.1 identified by similarity to GB:AAL60181.1; match to protein family HMM PF01478; match to protein family HMM PF06750; leader peptidase PppA 3322469 pppA 6144751 pppA Escherichia coli SMS-3-5 leader peptidase PppA YP_001745230.1 3321660 R 439855 CDS YP_001745231.1 170683116 6144240 complement(3322667..3327223) 1 NC_010498.1 hypothetical protein 3327223 6144240 EcSMS35_3251 Escherichia coli SMS-3-5 hypothetical protein YP_001745231.1 3322667 R 439855 CDS YP_001745232.1 170682106 6147335 complement(3327708..3329390) 1 NC_010498.1 identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795; glycolate transporter 3329390 glcA 6147335 glcA Escherichia coli SMS-3-5 glycolate transporter YP_001745232.1 3327708 R 439855 CDS YP_001745233.1 170681765 6146304 complement(3329745..3331916) 1 NC_010498.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3331916 glcB 6146304 glcB Escherichia coli SMS-3-5 malate synthase G YP_001745233.1 3329745 R 439855 CDS YP_001745234.1 170681117 6145956 complement(3331938..3332342) 1 NC_010498.1 identified by match to protein family HMM PF03928; hypothetical protein 3332342 6145956 EcSMS35_3254 Escherichia coli SMS-3-5 hypothetical protein YP_001745234.1 3331938 R 439855 CDS YP_001745235.1 170680842 6145300 complement(3332347..3333570) 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM PF02754; glycolate oxidase iron-sulfur subunit 3333570 glcF 6145300 glcF Escherichia coli SMS-3-5 glycolate oxidase iron-sulfur subunit YP_001745235.1 3332347 R 439855 CDS YP_001745236.1 170682017 6145019 complement(3333581..3334633) 1 NC_010498.1 identified by match to protein family HMM PF01565; glycolate oxidase FAD binding subunit 3334633 glcE 6145019 glcE Escherichia coli SMS-3-5 glycolate oxidase FAD binding subunit YP_001745236.1 3333581 R 439855 CDS YP_001745237.1 170682557 6146214 complement(3334633..3336123) 1 NC_010498.1 identified by match to protein family HMM PF01565; match to protein family HMM PF02913; match to protein family HMM TIGR00387; glycolate oxidase subunit GlcD 3336123 glcD 6146214 glcD Escherichia coli SMS-3-5 glycolate oxidase subunit GlcD YP_001745237.1 3334633 R 439855 CDS YP_001745238.1 170683351 6146760 3336383..3337153 1 NC_010498.1 identified by similarity to SP:P0ACL5; match to protein family HMM PF00392; match to protein family HMM PF07729; DNA-binding transcriptional regulator GlcC 3337153 glcC 6146760 glcC Escherichia coli SMS-3-5 DNA-binding transcriptional regulator GlcC YP_001745238.1 3336383 D 439855 CDS YP_001745239.1 170683858 6142637 complement(3337229..3338371) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3338371 6142637 EcSMS35_3259 Escherichia coli SMS-3-5 hypothetical protein YP_001745239.1 3337229 R 439855 CDS YP_001745240.1 170684019 6143153 3338775..3340466 1 NC_010498.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3340466 6143153 EcSMS35_3260 Escherichia coli SMS-3-5 acyl-CoA synthetase YP_001745240.1 3338775 D 439855 CDS YP_001745241.1 170680110 6143318 3340463..3341377 1 NC_010498.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; match to protein family HMM PF07993; NAD dependent epimerase/dehydratase family protein 3341377 6143318 EcSMS35_3261 Escherichia coli SMS-3-5 NAD dependent epimerase/dehydratase family protein YP_001745241.1 3340463 D 439855 CDS YP_001745242.1 170680622 6144275 3341409..3341657 1 NC_010498.1 identified by match to protein family HMM PF00550; putative acyl carrier protein 3341657 6144275 EcSMS35_3262 Escherichia coli SMS-3-5 putative acyl carrier protein YP_001745242.1 3341409 D 439855 CDS YP_001745243.1 170680202 6144797 3341657..3342829 1 NC_010498.1 identified by match to protein family HMM PF00155; match to protein family HMM PF00202; putative serine palmitoyltransferase 3342829 6144797 EcSMS35_3263 Escherichia coli SMS-3-5 putative serine palmitoyltransferase YP_001745243.1 3341657 D 439855 CDS YP_001745244.1 170681358 6144368 complement(3342864..3343943) 1 NC_010498.1 identified by match to protein family HMM PF03739; YjgP/YjgQ permease 3343943 6144368 EcSMS35_3264 Escherichia coli SMS-3-5 YjgP/YjgQ permease YP_001745244.1 3342864 R 439855 CDS YP_001745245.1 170683865 6145542 complement(3343940..3345010) 1 NC_010498.1 identified by match to protein family HMM PF03739; YjgP/YjgQ permease 3345010 6145542 EcSMS35_3265 Escherichia coli SMS-3-5 YjgP/YjgQ permease YP_001745245.1 3343940 R 439855 CDS YP_001745246.1 170682911 6143160 complement(3345041..3345601) 1 NC_010498.1 ytfJ; identified by match to protein family HMM TIGR01626; hypothetical protein 3345601 6143160 EcSMS35_3266 Escherichia coli SMS-3-5 hypothetical protein YP_001745246.1 3345041 R 439855 CDS YP_001745247.1 170682555 6147125 complement(3345613..3346437) 1 NC_010498.1 identified by similarity to GB:AAP18318.1; hypothetical protein 3346437 6147125 EcSMS35_3267 Escherichia coli SMS-3-5 hypothetical protein YP_001745247.1 3345613 R 439855 CDS YP_001745248.1 170681924 6146758 complement(3346437..3347786) 1 NC_010498.1 identified by match to protein family HMM PF01943; putative polysaccharide biosynthesis protein 3347786 6146758 EcSMS35_3268 Escherichia coli SMS-3-5 putative polysaccharide biosynthesis protein YP_001745248.1 3346437 R 439855 CDS YP_001745249.1 170681881 6146120 complement(3347832..3348590) 1 NC_010498.1 hypothetical protein 3348590 6146120 EcSMS35_3269 Escherichia coli SMS-3-5 hypothetical protein YP_001745249.1 3347832 R 439855 CDS YP_001745250.1 170681235 6146075 complement(3348622..3349320) 1 NC_010498.1 putative lipoprotein 3349320 6146075 EcSMS35_3270 Escherichia coli SMS-3-5 putative lipoprotein YP_001745250.1 3348622 R 439855 CDS YP_001745251.1 170680580 6145419 3349509..3350201 1 NC_010498.1 hypothetical protein 3350201 6145419 EcSMS35_3271 Escherichia coli SMS-3-5 hypothetical protein YP_001745251.1 3349509 D 439855 CDS YP_001745252.1 170680120 6144750 complement(3350250..3351749) 1 NC_010498.1 identified by match to protein family HMM PF01384; low-affinity inorganic phosphate transporter 2 3351749 pitB 6144750 pitB Escherichia coli SMS-3-5 low-affinity inorganic phosphate transporter 2 YP_001745252.1 3350250 R 439855 CDS YP_001745253.1 170681899 6144285 3351809..3351949 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3351949 6144285 EcSMS35_3273 Escherichia coli SMS-3-5 hypothetical protein YP_001745253.1 3351809 D 439855 CDS YP_001745254.1 170681256 6146094 complement(3352041..3353900) 1 NC_010498.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3353900 gsp 6146094 gsp Escherichia coli SMS-3-5 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_001745254.1 3352041 R 439855 CDS YP_001745255.1 170683583 6145440 3354105..3354971 1 NC_010498.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3354971 6145440 EcSMS35_3275 Escherichia coli SMS-3-5 putative glutathione S-transferase YghU YP_001745255.1 3354105 D 439855 CDS YP_001745256.1 170683074 6142874 complement(3355041..3355289) 1 NC_010498.1 identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074; hydrogenase 2 accessory protein HypG 3355289 hybG 6142874 hybG Escherichia coli SMS-3-5 hydrogenase 2 accessory protein HypG YP_001745256.1 3355041 R 439855 CDS YP_001745257.1 170681934 6147291 complement(3355302..3355643) 1 NC_010498.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3355643 hypA1 6147291 hypA1 Escherichia coli SMS-3-5 hydrogenase nickel incorporation protein HybF YP_001745257.1 3355302 R 439855 CDS YP_001745258.1 170682513 6146130 complement(3355636..3356124) 1 NC_010498.1 hydrogenase 2-specific chaperone 3356124 hybE 6146130 hybE Escherichia coli SMS-3-5 hydrogenase 2-specific chaperone YP_001745258.1 3355636 R 439855 CDS YP_001745259.1 170680954 6146713 complement(3356117..3356611) 1 NC_010498.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3356611 hybD 6146713 hybD Escherichia coli SMS-3-5 hydrogenase 2 maturation endopeptidase YP_001745259.1 3356117 R 439855 CDS YP_001745260.1 170680167 6145135 complement(3356611..3358314) 1 NC_010498.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3358314 hybC 6145135 hybC Escherichia coli SMS-3-5 hydrogenase 2 large subunit YP_001745260.1 3356611 R 439855 CDS YP_001745261.1 170680419 6144333 complement(3358311..3359489) 1 NC_010498.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit 3359489 hybB 6144333 hybB Escherichia coli SMS-3-5 putative hydrogenase 2 b cytochrome subunit YP_001745261.1 3358311 R 439855 CDS YP_001745262.1 170679790 6144588 complement(3359479..3360465) 1 NC_010498.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3360465 hybA 6144588 hybA Escherichia coli SMS-3-5 hydrogenase 2 protein HybA YP_001745262.1 3359479 R 439855 CDS YP_001745263.1 170684089 6143950 complement(3360468..3361586) 1 NC_010498.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3361586 hyb0 6143950 hyb0 Escherichia coli SMS-3-5 hydrogenase 2 small subunit YP_001745263.1 3360468 R 439855 CDS YP_001745264.1 170683429 6143389 3361570..3361698 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3361698 6143389 EcSMS35_3284 Escherichia coli SMS-3-5 hypothetical protein YP_001745264.1 3361570 D 439855 CDS YP_001745265.1 170683677 6142716 complement(3361775..3362062) 1 NC_010498.1 hypothetical protein 3362062 6142716 EcSMS35_3285 Escherichia coli SMS-3-5 hypothetical protein YP_001745265.1 3361775 R 439855 CDS YP_001745266.1 170684271 6142969 complement(3362181..3363068) 1 NC_010498.1 yghX; identified by match to protein family HMM PF01738; match to protein family HMM PF08840; dienelactone hydrolase family protein 3363068 6142969 EcSMS35_3286 Escherichia coli SMS-3-5 dienelactone hydrolase family protein YP_001745266.1 3362181 R 439855 CDS YP_001745267.1 170682381 6143573 3363225..3364265 1 NC_010498.1 identified by match to protein family HMM PF00248; aldo-keto reductase 3364265 6143573 EcSMS35_3287 Escherichia coli SMS-3-5 aldo-keto reductase YP_001745267.1 3363225 D 439855 CDS YP_001745268.1 170682896 6146580 complement(3364305..3364799) 1 NC_010498.1 identified by match to protein family HMM PF03350; match to protein family HMM TIGR00645; hypothetical protein 3364799 6146580 EcSMS35_3288 Escherichia coli SMS-3-5 hypothetical protein YP_001745268.1 3364305 R 439855 CDS YP_001745269.1 170683631 6147109 3364990..3365874 1 NC_010498.1 identified by match to protein family HMM PF00106; oxidoreductase 3365874 6147109 EcSMS35_3289 Escherichia coli SMS-3-5 oxidoreductase YP_001745269.1 3364990 D 439855 CDS YP_001745270.1 170681759 6142922 complement(3365912..3366337) 1 NC_010498.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3366337 exbD 6142922 exbD Escherichia coli SMS-3-5 biopolymer transport protein ExbD YP_001745270.1 3365912 R 439855 CDS YP_001745271.1 170680008 6145950 complement(3366344..3367078) 1 NC_010498.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3367078 exbB 6145950 exbB Escherichia coli SMS-3-5 biopolymer transport protein ExbB YP_001745271.1 3366344 R 439855 CDS YP_001745272.1 170680690 6144171 3367330..3368517 1 NC_010498.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3368517 metC 6144171 metC Escherichia coli SMS-3-5 cystathionine beta-lyase YP_001745272.1 3367330 D 439855 CDS YP_001745273.1 170683149 6144865 3368657..3369316 1 NC_010498.1 identified by match to protein family HMM PF09335; hypothetical protein 3369316 6144865 EcSMS35_3293 Escherichia coli SMS-3-5 hypothetical protein YP_001745273.1 3368657 D 439855 CDS YP_001745274.1 170683787 6147369 complement(3369356..3370255) 1 NC_010498.1 identified by match to protein family HMM PF00165; match to protein family HMM PF06719; AraC family transcriptional regulator 3370255 6147369 EcSMS35_3294 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001745274.1 3369356 R 439855 CDS YP_001745275.1 170683937 6143079 complement(3370252..3370398) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3370398 6143079 EcSMS35_3295 Escherichia coli SMS-3-5 hypothetical protein YP_001745275.1 3370252 R 439855 CDS YP_001745276.1 170682079 6143233 3370449..3371612 1 NC_010498.1 identified by match to protein family HMM PF00465; alcohol dehydrogenase yqhD 3371612 yqhD 6143233 yqhD Escherichia coli SMS-3-5 alcohol dehydrogenase yqhD YP_001745276.1 3370449 D 439855 CDS YP_001745277.1 170682599 6146276 3371717..3372544 1 NC_010498.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3372544 dkgA 6146276 dkgA Escherichia coli SMS-3-5 2,5-diketo-D-gluconate reductase A YP_001745277.1 3371717 D 439855 CDS YP_001745278.1 170680772 6146804 3372744..3373670 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3373670 6146804 EcSMS35_3298 Escherichia coli SMS-3-5 hypothetical protein YP_001745278.1 3372744 D 439855 CDS YP_001745279.1 170681297 6144947 3373721..3373978 1 NC_010498.1 putative outer membrane lipoprotein 3373978 6144947 EcSMS35_3299 Escherichia coli SMS-3-5 putative outer membrane lipoprotein YP_001745279.1 3373721 D 439855 CDS YP_001745280.1 170681820 6145481 complement(3374020..3376239) 1 NC_010498.1 identified by match to protein family HMM PF04055; match to protein family HMM PF08497; hypothetical protein 3376239 6145481 EcSMS35_3300 Escherichia coli SMS-3-5 hypothetical protein YP_001745280.1 3374020 R 439855 CDS YP_001745281.1 170684305 6146013 3376491..3377240 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 3377240 6146013 EcSMS35_3301 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001745281.1 3376491 D 439855 CDS YP_001745282.1 170683628 6143607 3377563..3379035 1 NC_010498.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase 3379035 6143607 EcSMS35_3302 Escherichia coli SMS-3-5 mannitol dehydrogenase YP_001745282.1 3377563 D 439855 CDS YP_001745283.1 170683214 6142919 3379032..3380048 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family protein 3380048 6142919 EcSMS35_3303 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family protein YP_001745283.1 3379032 D 439855 CDS YP_001745284.1 170680163 6147435 3380059..3381069 1 NC_010498.1 identified by match to protein family HMM PF02615; malate/L-lactate dehydrogenase family protein 3381069 6147435 EcSMS35_3304 Escherichia coli SMS-3-5 malate/L-lactate dehydrogenase family protein YP_001745284.1 3380059 D 439855 CDS YP_001745285.1 170683750 6144329 3381142..3382125 1 NC_010498.1 identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein 3382125 6144329 EcSMS35_3305 Escherichia coli SMS-3-5 TRAP transporter solute receptor DctP family protein YP_001745285.1 3381142 D 439855 CDS YP_001745286.1 170682721 6147460 3382660..3383964 1 NC_010498.1 identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter, DctM subunit 3383964 6147460 EcSMS35_3307 Escherichia coli SMS-3-5 TRAP transporter, DctM subunit YP_001745286.1 3382660 D 439855 CDS YP_001745287.1 170682156 6146929 complement(3384035..3385447) 1 NC_010498.1 identified by match to protein family HMM PF07731; match to protein family HMM PF07732; match to protein family HMM TIGR01409; repressor protein for FtsI 3385447 sufI 6146929 sufI Escherichia coli SMS-3-5 repressor protein for FtsI YP_001745287.1 3384035 R 439855 CDS YP_001745288.1 170681677 6146355 complement(3385522..3386259) 1 NC_010498.1 identified by match to protein family HMM PF01553; match to protein family HMM TIGR00530; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3386259 plsC 6146355 plsC Escherichia coli SMS-3-5 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001745288.1 3385522 R 439855 CDS YP_001745289.1 170681468 6145863 complement(3386493..3388751) 1 NC_010498.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3388751 parC 6145863 parC Escherichia coli SMS-3-5 DNA topoisomerase IV subunit A YP_001745289.1 3386493 R 439855 CDS YP_001745290.1 170680624 6145653 complement(3388889..3390496) 1 NC_010498.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein 3390496 6145653 EcSMS35_3311 Escherichia coli SMS-3-5 putative binding protein YP_001745290.1 3388889 R 439855 CDS YP_001745291.1 170679982 6144799 complement(3390605..3391087) 1 NC_010498.1 identified by match to protein family HMM PF06445; transcription activator effector binding domain/DNA gyrase inhibitor domain-containing protein 3391087 6144799 EcSMS35_3312 Escherichia coli SMS-3-5 transcription activator effector binding domain/DNA gyrase inhibitor domain-containing protein YP_001745291.1 3390605 R 439855 CDS YP_001745292.1 170682123 6144144 complement(3391140..3391532) 1 NC_010498.1 ygiW; identified by similarity to SP:P0ADU5; match to protein family HMM PF04076; match to protein family HMM TIGR00156; hypothetical protein 3391532 6144144 EcSMS35_3313 Escherichia coli SMS-3-5 hypothetical protein YP_001745292.1 3391140 R 439855 CDS YP_001745293.1 170683979 6146322 3391684..3392343 1 NC_010498.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3392343 qseB 6146322 qseB Escherichia coli SMS-3-5 DNA-binding transcriptional regulator QseB YP_001745293.1 3391684 D 439855 CDS YP_001745294.1 170682051 6143276 3392340..3393689 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein QseC 3393689 qseC 6143276 qseC Escherichia coli SMS-3-5 sensor protein QseC YP_001745294.1 3392340 D 439855 CDS YP_001745295.1 170682575 6146248 3393799..3394380 1 NC_010498.1 identified by match to protein family HMM PF02525; modulator of drug activity B 3394380 mdaB 6146248 mdaB Escherichia coli SMS-3-5 modulator of drug activity B YP_001745295.1 3393799 D 439855 CDS YP_001745296.1 170681782 6146780 3394411..3394725 1 NC_010498.1 identified by match to protein family HMM PF03992; quinol monooxygenase YgiN 3394725 ygiN 6146780 ygiN Escherichia coli SMS-3-5 quinol monooxygenase YgiN YP_001745296.1 3394411 D 439855 CDS YP_001745297.1 170681276 6145974 complement(3394770..3395657) 1 NC_010498.1 identified by similarity to GB:AAN82214.1; match to protein family HMM PF01380; match to protein family HMM PF01418; iron transport system regulatory protein FitR 3395657 fitR 6145974 fitR Escherichia coli SMS-3-5 iron transport system regulatory protein FitR YP_001745297.1 3394770 R 439855 CDS YP_001745298.1 170681989 6145460 complement(3395654..3396601) 1 NC_010498.1 identified by match to protein family HMM PF01497; iron ABC transporter periplasmic iron-binding protein FitE 3396601 fitE 6145460 fitE Escherichia coli SMS-3-5 iron ABC transporter periplasmic iron-binding protein FitE YP_001745298.1 3395654 R 439855 CDS YP_001745299.1 170683833 6146185 complement(3396612..3397661) 1 NC_010498.1 identified by similarity to GB:ABI52625.1; match to protein family HMM PF01032; iron ABC transporter permease FitD 3397661 fitD 6146185 fitD Escherichia coli SMS-3-5 iron ABC transporter permease FitD YP_001745299.1 3396612 R 439855 CDS YP_001745300.1 170683279 6143127 complement(3397658..3398641) 1 NC_010498.1 identified by match to protein family HMM PF01032; iron ABC transporter permease FitC 3398641 fitC 6143127 fitC Escherichia coli SMS-3-5 iron ABC transporter permease FitC YP_001745300.1 3397658 R 439855 CDS YP_001745301.1 170680408 6147505 complement(3398638..3399447) 1 NC_010498.1 identified by similarity to GB:ABI52623.1; match to protein family HMM PF00005; iron ABC transporter ATP binding protein FitB 3399447 fitB 6147505 fitB Escherichia coli SMS-3-5 iron ABC transporter ATP binding protein FitB YP_001745301.1 3398638 R 439855 CDS YP_001745302.1 170679905 6144577 complement(3399527..3399646) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3399646 6144577 EcSMS35_3323 Escherichia coli SMS-3-5 hypothetical protein YP_001745302.1 3399527 R 439855 CDS YP_001745303.1 170681849 6144067 3399821..3401962 1 NC_010498.1 identified by similarity to GB:ABI52622.1; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; TonB-dependent outer membrane ferric coprogen receptor FitA 3401962 fitA 6144067 fitA Escherichia coli SMS-3-5 TonB-dependent outer membrane ferric coprogen receptor FitA YP_001745303.1 3399821 D 439855 CDS YP_001745304.1 170679703 6146043 complement(3402026..3403918) 1 NC_010498.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3403918 parE 6146043 parE Escherichia coli SMS-3-5 DNA topoisomerase IV subunit B YP_001745304.1 3402026 R 439855 CDS YP_001745305.1 170684219 6143861 complement(3403947..3404528) 1 NC_010498.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3404528 yqiA 6143861 yqiA Escherichia coli SMS-3-5 esterase YqiA YP_001745305.1 3403947 R 439855 CDS YP_001745306.1 170683396 6143520 complement(3404528..3405355) 1 NC_010498.1 identified by match to protein family HMM PF00149; match to protein family HMM PF08413; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3405355 icc 6143520 icc Escherichia coli SMS-3-5 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_001745306.1 3404528 R 439855 CDS YP_001745307.1 170682587 6142682 complement(3405380..3405802) 1 NC_010498.1 identified by match to protein family HMM PF06853; hypothetical protein 3405802 6142682 EcSMS35_3328 Escherichia coli SMS-3-5 hypothetical protein YP_001745307.1 3405380 R 439855 CDS YP_001745308.1 170683347 6146792 complement(3405803..3406432) 1 NC_010498.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF 3406432 nudF 6146792 nudF Escherichia coli SMS-3-5 ADP-ribose pyrophosphatase NudF YP_001745308.1 3405803 R 439855 CDS YP_001745309.1 170682545 6142633 3406637..3408118 1 NC_010498.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3408118 tolC 6142633 tolC Escherichia coli SMS-3-5 outer membrane channel protein YP_001745309.1 3406637 D 439855 CDS YP_001745310.1 170681724 6146746 3408266..3408937 1 NC_010498.1 hypothetical protein 3408937 6146746 EcSMS35_3331 Escherichia coli SMS-3-5 hypothetical protein YP_001745310.1 3408266 D 439855 CDS YP_001745311.1 170681476 6145912 3408943..3410103 1 NC_010498.1 identified by match to protein family HMM PF03738; glutathionylspermidine synthase family protein 3410103 6145912 EcSMS35_3332 Escherichia coli SMS-3-5 glutathionylspermidine synthase family protein YP_001745311.1 3408943 D 439855 CDS YP_001745312.1 170680035 6145661 3410588..3412384 1 NC_010498.1 identified by match to protein family HMM PF05935; arylsulfate sulfotransferase 3412384 6145661 EcSMS35_3333 Escherichia coli SMS-3-5 arylsulfate sulfotransferase YP_001745312.1 3410588 D 439855 CDS YP_001745313.1 170681695 6144198 3412402..3413070 1 NC_010498.1 identified by similarity to SP:P0AEG4; match to protein family HMM PF01323; DsbA family thioredoxin 3413070 6144198 EcSMS35_3334 Escherichia coli SMS-3-5 DsbA family thioredoxin YP_001745313.1 3412402 D 439855 CDS YP_001745314.1 170681279 6145881 3413100..3413756 1 NC_010498.1 putative disulfide oxidoreductase 3413756 6145881 EcSMS35_3335 Escherichia coli SMS-3-5 putative disulfide oxidoreductase YP_001745314.1 3413100 D 439855 CDS YP_001745315.1 170680476 6145463 complement(3413802..3414590) 1 NC_010498.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3414590 6145463 EcSMS35_3336 Escherichia coli SMS-3-5 hypothetical protein YP_001745315.1 3413802 R 439855 CDS YP_001745316.1 170679914 6144645 3414733..3415506 1 NC_010498.1 identified by match to protein family HMM PF02535; zinc transporter ZupT 3415506 zupT 6144645 zupT Escherichia coli SMS-3-5 zinc transporter ZupT YP_001745316.1 3414733 D 439855 CDS YP_001745317.1 170679608 6144076 complement(3415564..3415758) 1 NC_010498.1 hypothetical protein 3415758 6144076 EcSMS35_3338 Escherichia coli SMS-3-5 hypothetical protein YP_001745317.1 3415564 R 439855 CDS YP_001745318.1 170683968 6143765 complement(3415996..3416649) 1 NC_010498.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3416649 ribB 6143765 ribB Escherichia coli SMS-3-5 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_001745318.1 3415996 R 439855 CDS YP_001745319.1 170684291 6143265 3416963..3417322 1 NC_010498.1 yqiC; identified by match to protein family HMM PF04380; hypothetical protein 3417322 6143265 EcSMS35_3340 Escherichia coli SMS-3-5 hypothetical protein YP_001745319.1 3416963 D 439855 CDS YP_001745320.1 170683608 6143593 complement(3417357..3417557) 1 NC_010498.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3417557 glgS 6143593 glgS Escherichia coli SMS-3-5 glycogen synthesis protein GlgS YP_001745320.1 3417357 R 439855 CDS YP_001745321.1 170682259 6142898 3417826..3418455 1 NC_010498.1 identified by match to protein family HMM PF07290; putative inner membrane protein 3418455 6142898 EcSMS35_3342 Escherichia coli SMS-3-5 putative inner membrane protein YP_001745321.1 3417826 D 439855 CDS YP_001745322.1 170681594 6146458 3418482..3420143 1 NC_010498.1 identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein 3420143 6146458 EcSMS35_3343 Escherichia coli SMS-3-5 SPFH domain-containing protein/band 7 family protein YP_001745322.1 3418482 D 439855 CDS YP_001745323.1 170683743 6145779 complement(3420937..3422370) 1 NC_010498.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3422370 hldE 6145779 hldE Escherichia coli SMS-3-5 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_001745323.1 3420937 R 439855 CDS YP_001745324.1 170680866 6143035 complement(3422418..3425258) 1 NC_010498.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3425258 glnE 6143035 glnE Escherichia coli SMS-3-5 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_001745324.1 3422418 R 439855 CDS YP_001745325.1 170682741 6145044 complement(3425281..3426582) 1 NC_010498.1 identified by match to protein family HMM PF01928; match to protein family HMM PF05235; adenylate cyclase 3426582 6145044 EcSMS35_3346 Escherichia coli SMS-3-5 adenylate cyclase YP_001745325.1 3425281 R 439855 CDS YP_001745326.1 170681635 6146949 complement(3426599..3426784) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3426784 6146949 EcSMS35_3347 Escherichia coli SMS-3-5 hypothetical protein YP_001745326.1 3426599 R 439855 CDS YP_001745327.1 170681115 6145821 3426824..3427444 1 NC_010498.1 putative signal transduction protein 3427444 6145821 EcSMS35_3348 Escherichia coli SMS-3-5 putative signal transduction protein YP_001745327.1 3426824 D 439855 CDS YP_001745328.1 170680641 6145298 3427508..3428746 1 NC_010498.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3428746 cca 6145298 cca Escherichia coli SMS-3-5 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_001745328.1 3427508 D 439855 CDS YP_001745329.1 170680114 6144816 complement(3428827..3429639) 1 NC_010498.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3429639 bacA 6144816 bacA Escherichia coli SMS-3-5 undecaprenyl pyrophosphate phosphatase YP_001745329.1 3428827 R 439855 CDS YP_001745330.1 170683805 6144279 complement(3429739..3430107) 1 NC_010498.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3430107 folB 6144279 folB Escherichia coli SMS-3-5 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_001745330.1 3429739 R 439855 CDS YP_001745331.1 170683365 6143099 3430212..3430829 1 NC_010498.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3430829 6143099 EcSMS35_3352 Escherichia coli SMS-3-5 putative glycerol-3-phosphate acyltransferase PlsY YP_001745331.1 3430212 D 439855 CDS YP_001745332.1 170682678 6142651 complement(3430842..3431774) 1 NC_010498.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3431774 ttdR 6142651 ttdR Escherichia coli SMS-3-5 transcriptional activator TtdR YP_001745332.1 3430842 R 439855 CDS YP_001745333.1 170683099 6146886 3431981..3432892 1 NC_010498.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3432892 ddtA 6146886 ddtA Escherichia coli SMS-3-5 tartrate dehydratase subunit alpha YP_001745333.1 3431981 D 439855 CDS YP_001745334.1 170683420 6147318 3432889..3433494 1 NC_010498.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3433494 ttdB 6147318 ttdB Escherichia coli SMS-3-5 L(+)-tartrate dehydratase subunit beta YP_001745334.1 3432889 D 439855 CDS YP_001745335.1 170681701 6142707 3433542..3435005 1 NC_010498.1 identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; anion transporter 3435005 6142707 EcSMS35_3356 Escherichia coli SMS-3-5 anion transporter YP_001745335.1 3433542 D 439855 CDS YP_001745336.1 170682206 6145887 complement(3435048..3436061) 1 NC_010498.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 3436061 gcp 6145887 gcp Escherichia coli SMS-3-5 putative DNA-binding/iron metalloprotein/AP endonuclease YP_001745336.1 3435048 R 439855 CDS YP_001745337.1 170680203 6146405 3436299..3436514 1 NC_010498.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3436514 rpsU 6146405 rpsU Escherichia coli SMS-3-5 30S ribosomal protein S21 YP_001745337.1 3436299 D 439855 CDS YP_001745338.1 170680884 6144369 3436625..3438370 1 NC_010498.1 synthesizes RNA primers at the replication forks; DNA primase 3438370 dnaG 6144369 dnaG Escherichia coli SMS-3-5 DNA primase YP_001745338.1 3436625 D 439855 CDS YP_001745339.1 170683578 6145062 3438565..3440406 1 NC_010498.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3440406 rpoD 6145062 rpoD Escherichia coli SMS-3-5 RNA polymerase sigma factor RpoD YP_001745339.1 3438565 D 439855 CDS YP_001745340.1 170684265 6142869 3440465..3441028 1 NC_010498.1 identified by match to protein family HMM PF08719; match to protein family HMM TIGR02464; hypothetical protein 3441028 6142869 EcSMS35_3361 Escherichia coli SMS-3-5 hypothetical protein YP_001745340.1 3440465 D 439855 CDS YP_001745341.1 170682273 6143567 complement(3441085..3441591) 1 NC_010498.1 identified by similarity to SP:P0A9H1; match to protein family HMM PF03167; G/U mismatch-specific DNA glycosylase 3441591 mug 6143567 mug Escherichia coli SMS-3-5 G/U mismatch-specific DNA glycosylase YP_001745341.1 3441085 R 439855 CDS YP_001745342.1 170682681 6143644 complement(3441845..3442609) 1 NC_010498.1 identified by match to protein family HMM PF04954; match to protein family HMM PF08021; siderophore-interacting protein 3442609 6143644 EcSMS35_3364 Escherichia coli SMS-3-5 siderophore-interacting protein YP_001745342.1 3441845 R 439855 CDS YP_001745343.1 170680145 6146889 3442896..3443519 1 NC_010498.1 identified by match to protein family HMM PF03551; PadR family transcriptional regulator 3443519 6146889 EcSMS35_3365 Escherichia coli SMS-3-5 PadR family transcriptional regulator YP_001745343.1 3442896 D 439855 CDS YP_001745344.1 170682786 6144311 complement(3443548..3445068) 1 NC_010498.1 identified by similarity to SP:P50466; match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF08447; match to protein family HMM TIGR00229; aerotaxis receptor 3445068 aer 6144311 aer Escherichia coli SMS-3-5 aerotaxis receptor YP_001745344.1 3443548 R 439855 CDS YP_001745345.1 170681164 6146995 3445576..3446865 1 NC_010498.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3446865 ygjG 6146995 ygjG Escherichia coli SMS-3-5 putrescine--2-oxoglutarate aminotransferase YP_001745345.1 3445576 D 439855 CDS YP_001745346.1 170681948 6145348 complement(3446907..3447239) 1 NC_010498.1 identified by match to protein family HMM PF01588; hypothetical protein 3447239 6145348 EcSMS35_3368 Escherichia coli SMS-3-5 hypothetical protein YP_001745346.1 3446907 R 439855 CDS YP_001745347.1 170682761 6146144 3447457..3448440 1 NC_010498.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; DNA-binding transcriptional repressor EbgR 3448440 ebgR 6146144 ebgR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor EbgR YP_001745347.1 3447457 D 439855 CDS YP_001745348.1 170680616 6146970 3448624..3451716 1 NC_010498.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3451716 ebgA 6146970 ebgA Escherichia coli SMS-3-5 cryptic beta-D-galactosidase subunit alpha YP_001745348.1 3448624 D 439855 CDS YP_001745349.1 170683783 6144790 3451713..3452162 1 NC_010498.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3452162 ebgC 6144790 ebgC Escherichia coli SMS-3-5 cryptic beta-D-galactosidase subunit beta YP_001745349.1 3451713 D 439855 CDS YP_001745350.1 170679908 6143075 3452225..3453658 1 NC_010498.1 identified by match to protein family HMM PF00324; amino acid permease family protein 3453658 6143075 EcSMS35_3372 Escherichia coli SMS-3-5 amino acid permease family protein YP_001745350.1 3452225 D 439855 CDS YP_001745351.1 170680553 6144070 3453792..3454862 1 NC_010498.1 hypothetical protein 3454862 6144070 EcSMS35_3373 Escherichia coli SMS-3-5 hypothetical protein YP_001745351.1 3453792 D 439855 CDS YP_001745352.1 170681156 6144723 3454879..3457230 1 NC_010498.1 putative glycosyl hydrolase 3457230 6144723 EcSMS35_3374 Escherichia coli SMS-3-5 putative glycosyl hydrolase YP_001745352.1 3454879 D 439855 CDS YP_001745353.1 170679814 6145339 3457401..3459419 1 NC_010498.1 identified by match to protein family HMM PF00724; match to protein family HMM PF01266; match to protein family HMM PF07992; 2,4-dienoyl-CoA reductase 3459419 fadH 6145339 fadH Escherichia coli SMS-3-5 2,4-dienoyl-CoA reductase YP_001745353.1 3457401 D 439855 CDS YP_001745354.1 170684079 6143975 complement(3459537..3460673) 1 NC_010498.1 identified by match to protein family HMM PF05175; match to protein family HMM PF08242; methyltransferase family protein 3460673 6143975 EcSMS35_3376 Escherichia coli SMS-3-5 methyltransferase family protein YP_001745354.1 3459537 R 439855 CDS YP_001745355.1 170683556 6143379 3460758..3461261 1 NC_010498.1 identified by match to protein family HMM PF01863; hypothetical protein 3461261 6143379 EcSMS35_3377 Escherichia coli SMS-3-5 hypothetical protein YP_001745355.1 3460758 D 439855 CDS YP_001745356.1 170682034 6142846 3461338..3462021 1 NC_010498.1 identified by match to protein family HMM PF02698; putative SanA protein 3462021 6142846 EcSMS35_3378 Escherichia coli SMS-3-5 putative SanA protein YP_001745356.1 3461338 D 439855 CDS YP_001745357.1 170682416 6146231 3462100..3463086 1 NC_010498.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase, NAD binding 3463086 6146231 EcSMS35_3379 Escherichia coli SMS-3-5 oxidoreductase, NAD binding YP_001745357.1 3462100 D 439855 CDS YP_001745358.1 170681879 6146615 3463370..3464335 1 NC_010498.1 identified by match to protein family HMM PF03741; protein Alx 3464335 alx 6146615 alx Escherichia coli SMS-3-5 protein Alx YP_001745358.1 3463370 D 439855 CDS YP_001745359.1 170681216 6146073 3464659..3465903 1 NC_010498.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3465903 sstT 6146073 sstT Escherichia coli SMS-3-5 serine/threonine transporter SstT YP_001745359.1 3464659 D 439855 CDS YP_001745360.1 170679962 6145400 complement(3465907..3466458) 1 NC_010498.1 putative inner membrane protein 3466458 6145400 EcSMS35_3382 Escherichia coli SMS-3-5 putative inner membrane protein YP_001745360.1 3465907 R 439855 CDS YP_001745361.1 170681891 6144124 complement(3466541..3468028) 1 NC_010498.1 identified by match to protein family HMM PF04295; match to protein family HMM PF08666; altronate dehydratase 3468028 uxaA 6144124 uxaA Escherichia coli SMS-3-5 altronate dehydratase YP_001745361.1 3466541 R 439855 CDS YP_001745362.1 170683343 6146085 complement(3468043..3469455) 1 NC_010498.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3469455 uxaC 6146085 uxaC Escherichia coli SMS-3-5 glucuronate isomerase YP_001745362.1 3468043 R 439855 CDS YP_001745363.1 170683899 6142629 3469938..3471236 1 NC_010498.1 identified by similarity to SP:P0AA78; match to protein family HMM PF07690; match to protein family HMM TIGR00893; hexuronate transporter 3471236 exuT 6142629 exuT Escherichia coli SMS-3-5 hexuronate transporter YP_001745363.1 3469938 D 439855 CDS YP_001745364.1 170684132 6143195 complement(3471312..3472406) 1 NC_010498.1 identified by match to protein family HMM PF07434; pilus biogenesis initiator 3472406 6143195 EcSMS35_3386 Escherichia coli SMS-3-5 pilus biogenesis initiator YP_001745364.1 3471312 R 439855 CDS YP_001745365.1 170682266 6143432 complement(3472403..3475087) 1 NC_010498.1 hypothetical protein 3475087 6143432 EcSMS35_3387 Escherichia coli SMS-3-5 hypothetical protein YP_001745365.1 3472403 R 439855 CDS YP_001745366.1 170683018 6146465 complement(3475178..3475678) 1 NC_010498.1 identified by match to protein family HMM PF04449; CS1 type fimbrial major subunit 3475678 6146465 EcSMS35_3388 Escherichia coli SMS-3-5 CS1 type fimbrial major subunit YP_001745366.1 3475178 R 439855 CDS YP_001745367.1 170681823 6147234 complement(3475708..3476424) 1 NC_010498.1 identified by similarity to SP:P25732; putative CFA/I fimbrial subunit A 3476424 6147234 EcSMS35_3389 Escherichia coli SMS-3-5 putative CFA/I fimbrial subunit A YP_001745367.1 3475708 R 439855 CDS YP_001745368.1 170682044 6146016 complement(3476504..3476632) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3476632 6146016 EcSMS35_3390 Escherichia coli SMS-3-5 hypothetical protein YP_001745368.1 3476504 R 439855 CDS YP_001745369.1 170680363 6146241 3476714..3477490 1 NC_010498.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3477490 exuR 6146241 exuR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor ExuR YP_001745369.1 3476714 D 439855 CDS YP_001745370.1 170681007 6144531 complement(3477676..3477792) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3477792 6144531 EcSMS35_3392 Escherichia coli SMS-3-5 hypothetical protein YP_001745370.1 3477676 R 439855 CDS YP_001745371.1 170684106 6145188 3477835..3478497 1 NC_010498.1 identified by match to protein family HMM PF09335; putative inner membrane protein 3478497 6145188 EcSMS35_3393 Escherichia coli SMS-3-5 putative inner membrane protein YP_001745371.1 3477835 D 439855 CDS YP_001745372.1 170680365 6143406 3478516..3478884 1 NC_010498.1 hypothetical protein 3478884 6143406 EcSMS35_3394 Escherichia coli SMS-3-5 hypothetical protein YP_001745372.1 3478516 D 439855 CDS YP_001745373.1 170680273 6144533 3479031..3479399 1 NC_010498.1 identified by match to protein family HMM PF06476; hypothetical protein 3479399 6144533 EcSMS35_3395 Escherichia coli SMS-3-5 hypothetical protein YP_001745373.1 3479031 D 439855 CDS YP_001745374.1 170681844 6144440 3479437..3479742 1 NC_010498.1 identified by match to protein family HMM PF05957; hypothetical protein 3479742 6144440 EcSMS35_3396 Escherichia coli SMS-3-5 hypothetical protein YP_001745374.1 3479437 D 439855 CDS YP_001745375.1 170683687 6146037 3479745..3480149 1 NC_010498.1 hypothetical protein 3480149 6146037 EcSMS35_3397 Escherichia coli SMS-3-5 hypothetical protein YP_001745375.1 3479745 D 439855 CDS YP_001745376.1 170680495 6142979 3480139..3480438 1 NC_010498.1 hypothetical protein 3480438 6142979 EcSMS35_3398 Escherichia coli SMS-3-5 hypothetical protein YP_001745376.1 3480139 D 439855 CDS YP_001745377.1 170682888 6144664 3480534..3481016 1 NC_010498.1 identified by match to protein family HMM PF07681; putative inner membrane protein YqjF 3481016 6144664 EcSMS35_3399 Escherichia coli SMS-3-5 putative inner membrane protein YqjF YP_001745377.1 3480534 D 439855 CDS YP_001745378.1 170682085 6147101 3481264..3482250 1 NC_010498.1 hypothetical protein 3482250 6147101 EcSMS35_3400 Escherichia coli SMS-3-5 hypothetical protein YP_001745378.1 3481264 D 439855 CDS YP_001745379.1 170681534 6146282 3482533..3482898 1 NC_010498.1 identified by match to protein family HMM PF05656; putative inner membrane protein YhaH 3482898 6146282 EcSMS35_3401 Escherichia coli SMS-3-5 putative inner membrane protein YhaH YP_001745379.1 3482533 D 439855 CDS YP_001745380.1 170680803 6145719 3483140..3483496 1 NC_010498.1 identified by match to protein family HMM PF05656; putative inner membrane protein 3483496 6145719 EcSMS35_3402 Escherichia coli SMS-3-5 putative inner membrane protein YP_001745380.1 3483140 D 439855 CDS YP_001745381.1 170679637 6144979 complement(3483547..3484443) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3484443 6144979 EcSMS35_3403 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001745381.1 3483547 R 439855 CDS YP_001745382.1 170681550 6143794 3484548..3485249 1 NC_010498.1 identified by match to protein family HMM PF02678; pirin family protein 3485249 6143794 EcSMS35_3404 Escherichia coli SMS-3-5 pirin family protein YP_001745382.1 3484548 D 439855 CDS YP_001745383.1 170681322 6145735 3485269..3485436 1 NC_010498.1 hypothetical protein 3485436 6145735 EcSMS35_3405 Escherichia coli SMS-3-5 hypothetical protein YP_001745383.1 3485269 D 439855 CDS YP_001745384.1 170681817 6145506 complement(3485569..3486879) 1 NC_010498.1 identified by match to protein family HMM PF06354; hypothetical protein 3486879 6145506 EcSMS35_3406 Escherichia coli SMS-3-5 hypothetical protein YP_001745384.1 3485569 R 439855 CDS YP_001745385.1 170679999 6146010 complement(3486907..3488238) 1 NC_010498.1 identified by match to protein family HMM TIGR00814; serine transporter family protein 3488238 6146010 EcSMS35_3407 Escherichia coli SMS-3-5 serine transporter family protein YP_001745385.1 3486907 R 439855 CDS YP_001745386.1 170680456 6144161 complement(3488513..3489883) 1 NC_010498.1 identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase TdcG 3489883 tdcG 6144161 tdcG Escherichia coli SMS-3-5 L-serine ammonia-lyase TdcG YP_001745386.1 3488513 R 439855 CDS YP_001745387.1 170680786 6144625 complement(3489949..3490338) 1 NC_010498.1 identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; hypothetical protein 3490338 6144625 EcSMS35_3409 Escherichia coli SMS-3-5 hypothetical protein YP_001745387.1 3489949 R 439855 CDS YP_001745388.1 170681495 6144961 complement(3490352..3492646) 1 NC_010498.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 3492646 pflB1 6144961 pflB1 Escherichia coli SMS-3-5 formate acetyltransferase YP_001745388.1 3490352 R 439855 CDS YP_001745389.1 170680069 6145680 complement(3492680..3493888) 1 NC_010498.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3493888 tdcD 6145680 tdcD Escherichia coli SMS-3-5 propionate/acetate kinase YP_001745389.1 3492680 R 439855 CDS YP_001745390.1 170680237 6144233 complement(3493914..3495245) 1 NC_010498.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3495245 tdcC 6144233 tdcC Escherichia coli SMS-3-5 threonine/serine transporter TdcC YP_001745390.1 3493914 R 439855 CDS YP_001745391.1 170683614 6144404 complement(3495267..3496256) 1 NC_010498.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3496256 tdcB 6144404 tdcB Escherichia coli SMS-3-5 threonine dehydratase YP_001745391.1 3495267 R 439855 CDS YP_001745392.1 170684278 6142904 complement(3496355..3497293) 1 NC_010498.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3497293 tdcA 6142904 tdcA Escherichia coli SMS-3-5 DNA-binding transcriptional activator TdcA YP_001745392.1 3496355 R 439855 CDS YP_001745393.1 170680434 6143580 3497482..3497826 1 NC_010498.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3497826 tdcR 6143580 tdcR Escherichia coli SMS-3-5 DNA-binding transcriptional activator TdcR YP_001745393.1 3497482 D 439855 CDS YP_001745394.1 170681106 6144603 complement(3497908..3498045) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3498045 6144603 EcSMS35_3416 Escherichia coli SMS-3-5 hypothetical protein YP_001745394.1 3497908 R 439855 CDS YP_001745395.1 170683716 6145288 3498082..3498621 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3498621 6145288 EcSMS35_3417 Escherichia coli SMS-3-5 hypothetical protein YP_001745395.1 3498082 D 439855 CDS YP_001745396.1 170679783 6143008 3498643..3499830 1 NC_010498.1 yhaC; identified by similarity to SP:P11864; hypothetical protein 3499830 6143008 EcSMS35_3418 Escherichia coli SMS-3-5 hypothetical protein YP_001745396.1 3498643 D 439855 CDS YP_001745397.1 170683586 6143943 complement(3500461..3501606) 1 NC_010498.1 identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase I 3501606 garK 6143943 garK Escherichia coli SMS-3-5 glycerate kinase I YP_001745397.1 3500461 R 439855 CDS YP_001745398.1 170683197 6142877 complement(3501703..3502587) 1 NC_010498.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3502587 garR 6142877 garR Escherichia coli SMS-3-5 tartronate semialdehyde reductase YP_001745398.1 3501703 R 439855 CDS YP_001745399.1 170682298 6147417 complement(3502623..3503393) 1 NC_010498.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3503393 garL 6147417 garL Escherichia coli SMS-3-5 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_001745399.1 3502623 R 439855 CDS YP_001745400.1 170683081 6146497 complement(3503409..3504743) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; galactarate permease GarP 3504743 garP 6146497 garP Escherichia coli SMS-3-5 galactarate permease GarP YP_001745400.1 3503409 R 439855 CDS YP_001745401.1 170680979 6147298 3504764..3504889 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3504889 6147298 EcSMS35_3423 Escherichia coli SMS-3-5 hypothetical protein YP_001745401.1 3504764 D 439855 CDS YP_001745402.1 170681459 6145160 3504952..3505071 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3505071 6145160 EcSMS35_3424 Escherichia coli SMS-3-5 hypothetical protein YP_001745402.1 3504952 D 439855 CDS YP_001745403.1 170680919 6145644 3505118..3506689 1 NC_010498.1 identified by match to protein family HMM PF04295; match to protein family HMM PF08666; match to protein family HMM TIGR03248; galactarate dehydratase 3506689 garD 6145644 garD Escherichia coli SMS-3-5 galactarate dehydratase YP_001745403.1 3505118 D 439855 CDS YP_001745404.1 170681751 6145100 3507033..3507173 1 NC_010498.1 HtrA suppressor protein SohA 3507173 sohA 6145100 sohA Escherichia coli SMS-3-5 HtrA suppressor protein SohA YP_001745404.1 3507033 D 439855 CDS YP_001745405.1 170682166 6145941 3507173..3507637 1 NC_010498.1 hypothetical protein 3507637 6145941 EcSMS35_3427 Escherichia coli SMS-3-5 hypothetical protein YP_001745405.1 3507173 D 439855 CDS YP_001745406.1 170680176 6146365 complement(3507692..3508501) 1 NC_010498.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3508501 6146365 EcSMS35_3428 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator AgaR YP_001745406.1 3507692 R 439855 CDS YP_001745407.1 170680844 6144342 3508750..3510030 1 NC_010498.1 identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810; D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit 3510030 6144342 EcSMS35_3429 Escherichia coli SMS-3-5 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit YP_001745407.1 3508750 D 439855 CDS YP_001745408.1 170683585 6145021 3510053..3510526 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3510526 agaV 6145021 agaV Escherichia coli SMS-3-5 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_001745408.1 3510053 D 439855 CDS YP_001745409.1 170684243 6142876 3510537..3511316 1 NC_010498.1 identified by match to protein family HMM PF03609; PTS system, N-acetylgalactosamine-specific, IIC component 3511316 agaW 6142876 agaW Escherichia coli SMS-3-5 PTS system, N-acetylgalactosamine-specific, IIC component YP_001745409.1 3510537 D 439855 CDS YP_001745410.1 170683484 6143544 3511306..3512184 1 NC_010498.1 identified by match to protein family HMM PF03613; PTS system N-acetylgalactosamine-specific, IID component 3512184 agaE 6143544 agaE Escherichia coli SMS-3-5 PTS system N-acetylgalactosamine-specific, IID component YP_001745410.1 3511306 D 439855 CDS YP_001745411.1 170684074 6142773 3512202..3512636 1 NC_010498.1 identified by match to protein family HMM PF03610; PTS system, mannose/sorbose-specific, IIA component 3512636 agaF 6142773 agaF Escherichia coli SMS-3-5 PTS system, mannose/sorbose-specific, IIA component YP_001745411.1 3512202 D 439855 CDS YP_001745412.1 170681130 6143374 3512612..3513766 1 NC_010498.1 identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 3513766 nagA1 6143374 nagA1 Escherichia coli SMS-3-5 N-acetylglucosamine-6-phosphate deacetylase YP_001745412.1 3512612 D 439855 CDS YP_001745413.1 170682634 6145313 3514117..3515271 1 NC_010498.1 identified by match to protein family HMM PF01380; match to protein family HMM TIGR02815; AgaS family sugar isomerase 3515271 6145313 EcSMS35_3435 Escherichia coli SMS-3-5 AgaS family sugar isomerase YP_001745413.1 3514117 D 439855 CDS YP_001745414.1 170682643 6146840 3515284..3516144 1 NC_010498.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3516144 kbaY 6146840 kbaY Escherichia coli SMS-3-5 tagatose-bisphosphate aldolase YP_001745414.1 3515284 D 439855 CDS YP_001745415.1 170683275 6146849 3516311..3516787 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3516787 agaB 6146849 agaB Escherichia coli SMS-3-5 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_001745415.1 3516311 D 439855 CDS YP_001745416.1 170681846 6147501 3516826..3517629 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3517629 agaC 6147501 agaC Escherichia coli SMS-3-5 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_001745416.1 3516826 D 439855 CDS YP_001745417.1 170681996 6146039 3517619..3518410 1 NC_010498.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3518410 agaD 6146039 agaD Escherichia coli SMS-3-5 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_001745417.1 3517619 D 439855 CDS YP_001745418.1 170681234 6146192 3518411..3519178 1 NC_010498.1 identified by similarity to SP:P42912; match to protein family HMM PF01182; galactosamine-6-phosphate isomerase 3519178 6146192 EcSMS35_3440 Escherichia coli SMS-3-5 galactosamine-6-phosphate isomerase YP_001745418.1 3518411 D 439855 CDS YP_001745419.1 170681783 6145418 complement(3519228..3520091) 1 NC_010498.1 yraL; identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; tetrapyrrole methylase family protein 3520091 6145418 EcSMS35_3441 Escherichia coli SMS-3-5 tetrapyrrole methylase family protein YP_001745419.1 3519228 R 439855 CDS YP_001745420.1 170679956 6145975 3520156..3522192 1 NC_010498.1 identified by match to protein family HMM PF04348; putative lipoprotein 3522192 6145975 EcSMS35_3442 Escherichia coli SMS-3-5 putative lipoprotein YP_001745420.1 3520156 D 439855 CDS YP_001745421.1 170680465 6144118 3522150..3522545 1 NC_010498.1 yraN; identified by match to protein family HMM PF02021; match to protein family HMM TIGR00252; hypothetical protein 3522545 6144118 EcSMS35_3443 Escherichia coli SMS-3-5 hypothetical protein YP_001745421.1 3522150 D 439855 CDS YP_001745422.1 170682125 6144634 3522565..3523155 1 NC_010498.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3523155 diaA 6144634 diaA Escherichia coli SMS-3-5 DnaA initiator-associating protein DiaA YP_001745422.1 3522565 D 439855 CDS YP_001745423.1 170680506 6146324 3523165..3523740 1 NC_010498.1 identified by match to protein family HMM PF04972; hypothetical protein 3523740 6146324 EcSMS35_3445 Escherichia coli SMS-3-5 hypothetical protein YP_001745423.1 3523165 D 439855 CDS YP_001745424.1 170683334 6144676 complement(3523853..3524893) 1 NC_010498.1 identified by match to protein family HMM PF03773; putative permease 3524893 6144676 EcSMS35_3446 Escherichia coli SMS-3-5 putative permease YP_001745424.1 3523853 R 439855 CDS YP_001745425.1 170680214 6142619 complement(3524966..3525601) 1 NC_010498.1 identified by match to protein family HMM PF01370; NAD dependent epimerase/dehydratase family protein 3525601 6142619 EcSMS35_3447 Escherichia coli SMS-3-5 NAD dependent epimerase/dehydratase family protein YP_001745425.1 3524966 R 439855 CDS YP_001745426.1 170683857 6144380 3525729..3526247 1 NC_010498.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01382; PfpI family intracellular peptidase 3526247 6144380 EcSMS35_3449 Escherichia coli SMS-3-5 PfpI family intracellular peptidase YP_001745426.1 3525729 D 439855 CDS YP_001745427.1 170682320 6143152 complement(3526227..3526670) 1 NC_010498.1 hypothetical protein 3526670 6143152 EcSMS35_3448 Escherichia coli SMS-3-5 hypothetical protein YP_001745427.1 3526227 R 439855 CDS YP_001745428.1 170681935 6146519 3526721..3527023 1 NC_010498.1 identified by match to protein family HMM PF01541; GIY-YIG nuclease superfamily protein 3527023 6146519 EcSMS35_3451 Escherichia coli SMS-3-5 GIY-YIG nuclease superfamily protein YP_001745428.1 3526721 D 439855 CDS YP_001745429.1 170682653 6146131 complement(3527010..3527513) 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 3527513 6146131 EcSMS35_3450 Escherichia coli SMS-3-5 acetyltransferase YP_001745429.1 3527010 R 439855 CDS YP_001745430.1 170680098 6146860 complement(3527507..3528031) 1 NC_010498.1 identified by match to protein family HMM PF02036; sterol-binding protein 3528031 6146860 EcSMS35_3452 Escherichia coli SMS-3-5 sterol-binding protein YP_001745430.1 3527507 R 439855 CDS YP_001745431.1 170681790 6144262 complement(3528021..3528134) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3528134 6144262 EcSMS35_3453 Escherichia coli SMS-3-5 hypothetical protein YP_001745431.1 3528021 R 439855 CDS YP_001745432.1 170683910 6145982 3528240..3529235 1 NC_010498.1 identified by match to protein family HMM PF01136; U32 family peptidase 3529235 6145982 EcSMS35_3454 Escherichia coli SMS-3-5 U32 family peptidase YP_001745432.1 3528240 D 439855 CDS YP_001745433.1 170684049 6143206 3529244..3530122 1 NC_010498.1 identified by match to protein family HMM PF01136; U32 family peptidase 3530122 6143206 EcSMS35_3455 Escherichia coli SMS-3-5 U32 family peptidase YP_001745433.1 3529244 D 439855 CDS YP_001745434.1 170679737 6143348 3530203..3531210 1 NC_010498.1 identified by match to protein family HMM PF00296; hypothetical protein 3531210 6143348 EcSMS35_3456 Escherichia coli SMS-3-5 hypothetical protein YP_001745434.1 3530203 D 439855 CDS YP_001745435.1 170683709 6143895 complement(3531329..3532573) 1 NC_010498.1 tryptophan transporter of high affinity; tryptophan permease 3532573 mtr 6143895 mtr Escherichia coli SMS-3-5 tryptophan permease YP_001745435.1 3531329 R 439855 CDS YP_001745436.1 170684314 6143001 complement(3532727..3534616) 1 NC_010498.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3534616 deaD 6143001 deaD Escherichia coli SMS-3-5 ATP-dependent RNA helicase DeaD YP_001745436.1 3532727 R 439855 CDS YP_001745437.1 170682635 6143616 complement(3534796..3535680) 1 NC_010498.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3535680 nlpI 6143616 nlpI Escherichia coli SMS-3-5 lipoprotein NlpI YP_001745437.1 3534796 R 439855 CDS YP_001745438.1 170682265 6146841 complement(3535789..3537924) 1 NC_010498.1 identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 3537924 pnp 6146841 pnp Escherichia coli SMS-3-5 polynucleotide phosphorylase/polyadenylase YP_001745438.1 3535789 R 439855 CDS YP_001745439.1 170681850 6146464 complement(3538171..3538440) 1 NC_010498.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3538440 rpsO 6146464 rpsO Escherichia coli SMS-3-5 30S ribosomal protein S15 YP_001745439.1 3538171 R 439855 CDS YP_001745440.1 170680914 6146044 complement(3538589..3539533) 1 NC_010498.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3539533 truB 6146044 truB Escherichia coli SMS-3-5 tRNA pseudouridine synthase B YP_001745440.1 3538589 R 439855 CDS YP_001745441.1 170680547 6145095 complement(3539533..3539934) 1 NC_010498.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3539934 rbfA 6145095 rbfA Escherichia coli SMS-3-5 ribosome-binding factor A YP_001745441.1 3539533 R 439855 CDS YP_001745442.1 170683744 6144717 complement(3540098..3542770) 1 NC_010498.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3542770 infB 6144717 infB Escherichia coli SMS-3-5 translation initiation factor IF-2 YP_001745442.1 3540098 R 439855 CDS YP_001745443.1 170680571 6143036 complement(3542795..3544282) 1 NC_010498.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3544282 nusA 6143036 nusA Escherichia coli SMS-3-5 transcription elongation factor NusA YP_001745443.1 3542795 R 439855 CDS YP_001745444.1 170680823 6144741 complement(3544310..3544774) 1 NC_010498.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3544774 6144741 EcSMS35_3466 Escherichia coli SMS-3-5 hypothetical protein YP_001745444.1 3544310 R 439855 CDS YP_001745445.1 170681371 6143631 3545393..3546736 1 NC_010498.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3546736 argG 6143631 argG Escherichia coli SMS-3-5 argininosuccinate synthase YP_001745445.1 3545393 D 439855 CDS YP_001745446.1 170680504 6145555 complement(3546744..3548261) 1 NC_010498.1 identified by match to protein family HMM PF00884; inner membrane protein yhbX 3548261 yhbX 6145555 yhbX Escherichia coli SMS-3-5 inner membrane protein yhbX YP_001745446.1 3546744 R 439855 CDS YP_001745447.1 170680429 6143620 complement(3548929..3549261) 1 NC_010498.1 identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 3549261 secG 6143620 secG Escherichia coli SMS-3-5 preprotein translocase subunit SecG YP_001745447.1 3548929 R 439855 CDS YP_001745448.1 170684162 6144598 complement(3549489..3550826) 1 NC_010498.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3550826 glmM 6144598 glmM Escherichia coli SMS-3-5 phosphoglucosamine mutase YP_001745448.1 3549489 R 439855 CDS YP_001745449.1 170682317 6143462 complement(3550819..3551667) 1 NC_010498.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3551667 folP 6143462 folP Escherichia coli SMS-3-5 dihydropteroate synthase YP_001745449.1 3550819 R 439855 CDS YP_001745450.1 170682536 6146516 complement(3551757..3553700) 1 NC_010498.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3553700 hflB 6146516 hflB Escherichia coli SMS-3-5 ATP-dependent metalloprotease YP_001745450.1 3551757 R 439855 CDS YP_001745451.1 170681323 6146737 complement(3553791..3554420) 1 NC_010498.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 3554420 rrmJ 6146737 rrmJ Escherichia coli SMS-3-5 23S rRNA methyltransferase J YP_001745451.1 3553791 R 439855 CDS YP_001745452.1 170681512 6145507 3554546..3554839 1 NC_010498.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3554839 6145507 EcSMS35_3476 Escherichia coli SMS-3-5 RNA-binding protein YhbY YP_001745452.1 3554546 D 439855 CDS YP_001745453.1 170683303 6145697 complement(3554995..3555471) 1 NC_010498.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3555471 greA 6145697 greA Escherichia coli SMS-3-5 transcription elongation factor GreA YP_001745453.1 3554995 R 439855 CDS YP_001745454.1 170681453 6147529 3555720..3557153 1 NC_010498.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3557153 dacB 6147529 dacB Escherichia coli SMS-3-5 D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_001745454.1 3555720 D 439855 CDS YP_001745455.1 170683110 6145638 complement(3557194..3558366) 1 NC_010498.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3558366 obgE 6145638 obgE Escherichia coli SMS-3-5 GTPase ObgE YP_001745455.1 3557194 R 439855 CDS YP_001745456.1 170682428 6147329 complement(3558382..3559347) 1 NC_010498.1 identified by match to protein family HMM PF00892; putative transporter 3559347 6147329 EcSMS35_3480 Escherichia coli SMS-3-5 putative transporter YP_001745456.1 3558382 R 439855 CDS YP_001745457.1 170684123 6146627 complement(3559474..3559731) 1 NC_010498.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3559731 rpmA 6146627 rpmA Escherichia coli SMS-3-5 50S ribosomal protein L27 YP_001745457.1 3559474 R 439855 CDS YP_001745458.1 170684040 6143423 complement(3559752..3560063) 1 NC_010498.1 identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 3560063 rplU 6143423 rplU Escherichia coli SMS-3-5 50S ribosomal protein L21 YP_001745458.1 3559752 R 439855 CDS YP_001745459.1 170683435 6143339 3560322..3561293 1 NC_010498.1 identified by match to protein family HMM PF00348; octaprenyl diphosphate synthase 3561293 ispB 6143339 ispB Escherichia coli SMS-3-5 octaprenyl diphosphate synthase YP_001745459.1 3560322 D 439855 CDS YP_001745460.1 170680402 6142722 3561522..3561800 1 NC_010498.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3561800 sfsB 6142722 sfsB Escherichia coli SMS-3-5 DNA-binding transcriptional regulator Nlp YP_001745460.1 3561522 D 439855 CDS YP_001745461.1 170679709 6144571 complement(3561848..3563107) 1 NC_010498.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3563107 murA 6144571 murA Escherichia coli SMS-3-5 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001745461.1 3561848 R 439855 CDS YP_001745462.1 170683064 6143867 complement(3563162..3563431) 1 NC_010498.1 identified by match to protein family HMM PF01722; BolA/YrbA family protein 3563431 6143867 EcSMS35_3486 Escherichia coli SMS-3-5 BolA/YrbA family protein YP_001745462.1 3563162 R 439855 CDS YP_001745463.1 170684008 6147281 complement(3563576..3563869) 1 NC_010498.1 YrbB 3563869 yrbB 6147281 yrbB Escherichia coli SMS-3-5 YrbB YP_001745463.1 3563576 R 439855 CDS YP_001745464.1 170682535 6143307 complement(3563869..3564504) 1 NC_010498.1 identified by match to protein family HMM PF05494; toluene tolerance protein Ttg2D 3564504 ttg2D 6143307 ttg2D Escherichia coli SMS-3-5 toluene tolerance protein Ttg2D YP_001745464.1 3563869 R 439855 CDS YP_001745465.1 170682506 6146736 complement(3564523..3565074) 1 NC_010498.1 identified by match to protein family HMM PF02470; Mce family protein 3565074 6146736 EcSMS35_3489 Escherichia coli SMS-3-5 Mce family protein YP_001745465.1 3564523 R 439855 CDS YP_001745466.1 170684208 6146706 complement(3565079..3565861) 1 NC_010498.1 identified by match to protein family HMM PF02405; match to protein family HMM TIGR00056; toluene ABC transporter permease 3565861 6146706 EcSMS35_3490 Escherichia coli SMS-3-5 toluene ABC transporter permease YP_001745466.1 3565079 R 439855 CDS YP_001745467.1 170683530 6143509 complement(3565869..3566678) 1 NC_010498.1 ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF 3566678 6143509 EcSMS35_3491 Escherichia coli SMS-3-5 putative ABC transporter ATP-binding protein YrbF YP_001745467.1 3565869 R 439855 CDS YP_001745468.1 170679873 6142820 3566888..3567865 1 NC_010498.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3567865 6142820 EcSMS35_3492 Escherichia coli SMS-3-5 putative calcium/sodium:proton antiporter YP_001745468.1 3566888 D 439855 CDS YP_001745469.1 170679857 6144035 3567879..3568865 1 NC_010498.1 identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393; D-arabinose 5-phosphate isomerase 3568865 kdsD 6144035 kdsD Escherichia coli SMS-3-5 D-arabinose 5-phosphate isomerase YP_001745469.1 3567879 D 439855 CDS YP_001745470.1 170681509 6144019 3568886..3569452 1 NC_010498.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3569452 kdsC 6144019 kdsC Escherichia coli SMS-3-5 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_001745470.1 3568886 D 439855 CDS YP_001745471.1 170680880 6145694 3569449..3570024 1 NC_010498.1 identified by match to protein family HMM PF06835; hypothetical protein 3570024 6145694 EcSMS35_3495 Escherichia coli SMS-3-5 hypothetical protein YP_001745471.1 3569449 D 439855 CDS YP_001745472.1 170682501 6145058 3569993..3570550 1 NC_010498.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3570550 lptA 6145058 lptA Escherichia coli SMS-3-5 lipopolysaccharide transport periplasmic protein LptA YP_001745472.1 3569993 D 439855 CDS YP_001745473.1 170680394 6146701 3570557..3571282 1 NC_010498.1 identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein YhbG 3571282 lptB 6146701 lptB Escherichia coli SMS-3-5 putative ABC transporter ATP-binding protein YhbG YP_001745473.1 3570557 D 439855 CDS YP_001745474.1 170684031 6144563 3571330..3572763 1 NC_010498.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3572763 rpoN 6144563 rpoN Escherichia coli SMS-3-5 RNA polymerase factor sigma-54 YP_001745474.1 3571330 D 439855 CDS YP_001745475.1 170683293 6143330 3572786..3573073 1 NC_010498.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3573073 yfiA 6143330 yfiA Escherichia coli SMS-3-5 putative sigma(54) modulation protein YP_001745475.1 3572786 D 439855 CDS YP_001745476.1 170680578 6147519 3573191..3573682 1 NC_010498.1 identified by match to protein family HMM PF00359; match to protein family HMM TIGR01419; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3573682 ptsN 6147519 ptsN Escherichia coli SMS-3-5 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_001745476.1 3573191 D 439855 CDS YP_001745477.1 170679896 6144748 3573728..3574582 1 NC_010498.1 identified by match to protein family HMM PF03668; hypothetical protein 3574582 6144748 EcSMS35_3501 Escherichia coli SMS-3-5 hypothetical protein YP_001745477.1 3573728 D 439855 CDS YP_001745478.1 170680806 6144058 3574579..3574851 1 NC_010498.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3574851 ptsO 6144058 ptsO Escherichia coli SMS-3-5 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_001745478.1 3574579 D 439855 CDS YP_001745479.1 170682070 6144982 3575065..3575697 1 NC_010498.1 hypothetical protein 3575697 6144982 EcSMS35_3504 Escherichia coli SMS-3-5 hypothetical protein YP_001745479.1 3575065 D 439855 CDS YP_001745480.1 170681307 6146267 complement(3575694..3576422) 1 NC_010498.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3576422 mtgA 6146267 mtgA Escherichia coli SMS-3-5 monofunctional biosynthetic peptidoglycan transglycosylase YP_001745480.1 3575694 R 439855 CDS YP_001745481.1 170683821 6145491 complement(3576419..3577072) 1 NC_010498.1 identified by match to protein family HMM PF01965; isoprenoid biosynthesis protein with amidotransferase-like domain 3577072 elbB 6145491 elbB Escherichia coli SMS-3-5 isoprenoid biosynthesis protein with amidotransferase-like domain YP_001745481.1 3576419 R 439855 CDS YP_001745482.1 170683438 6143115 complement(3577302..3579638) 1 NC_010498.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3579638 arcB 6143115 arcB Escherichia coli SMS-3-5 aerobic respiration control sensor protein ArcB YP_001745482.1 3577302 R 439855 CDS YP_001745483.1 170683121 6142725 complement(3579734..3580663) 1 NC_010498.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR01212; radical SAM family protein 3580663 6142725 EcSMS35_3507 Escherichia coli SMS-3-5 radical SAM family protein YP_001745483.1 3579734 R 439855 CDS YP_001745484.1 170682676 6147340 3581244..3585797 1 NC_010498.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3585797 gltB 6147340 gltB Escherichia coli SMS-3-5 glutamate synthase subunit alpha YP_001745484.1 3581244 D 439855 CDS YP_001745485.1 170682339 6146884 3585810..3587228 1 NC_010498.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3587228 gltD 6146884 gltD Escherichia coli SMS-3-5 glutamate synthase subunit beta YP_001745485.1 3585810 D 439855 CDS YP_001745486.1 170683811 6146538 3587461..3588783 1 NC_010498.1 identified by match to protein family HMM PF04434; SWIM zinc finger domain-containing protein 3588783 6146538 EcSMS35_3510 Escherichia coli SMS-3-5 SWIM zinc finger domain-containing protein YP_001745486.1 3587461 D 439855 CDS YP_001745487.1 170683178 6143105 3588780..3590384 1 NC_010498.1 hypothetical protein 3590384 6143105 EcSMS35_3511 Escherichia coli SMS-3-5 hypothetical protein YP_001745487.1 3588780 D 439855 CDS YP_001745488.1 170680609 6147398 3590381..3591475 1 NC_010498.1 identified by match to protein family HMM PF07728; AAA family ATPase 3591475 6147398 EcSMS35_3512 Escherichia coli SMS-3-5 AAA family ATPase YP_001745488.1 3590381 D 439855 CDS YP_001745489.1 170681434 6144783 3591493..3593742 1 NC_010498.1 hypothetical protein 3593742 6144783 EcSMS35_3513 Escherichia coli SMS-3-5 hypothetical protein YP_001745489.1 3591493 D 439855 CDS YP_001745490.1 170681772 6145618 3593732..3594901 1 NC_010498.1 identified by match to protein family HMM PF05762; VWA domain-containing protein 3594901 6145618 EcSMS35_3514 Escherichia coli SMS-3-5 VWA domain-containing protein YP_001745490.1 3593732 D 439855 CDS YP_001745491.1 170681084 6145964 complement(3595123..3595269) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3595269 6145964 EcSMS35_3515 Escherichia coli SMS-3-5 hypothetical protein YP_001745491.1 3595123 R 439855 CDS YP_001745492.1 170682177 6145266 complement(3595939..3596403) 1 NC_010498.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 3596403 6145266 EcSMS35_3516 Escherichia coli SMS-3-5 hypothetical protein YP_001745492.1 3595939 R 439855 CDS YP_001745493.1 170683075 6146376 complement(3596400..3597275) 1 NC_010498.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3597275 6146376 EcSMS35_3517 Escherichia coli SMS-3-5 N-acetylmannosamine kinase YP_001745493.1 3596400 R 439855 CDS YP_001745494.1 170683961 6147292 complement(3597272..3597961) 1 NC_010498.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3597961 6147292 EcSMS35_3518 Escherichia coli SMS-3-5 N-acetylmannosamine-6-phosphate 2-epimerase YP_001745494.1 3597272 R 439855 CDS YP_001745495.1 170683321 6143258 complement(3598009..3599499) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00891; putative sialic acid transporter 3599499 nanT1 6143258 nanT1 Escherichia coli SMS-3-5 putative sialic acid transporter YP_001745495.1 3598009 R 439855 CDS YP_001745496.1 170680563 6142606 complement(3599608..3600501) 1 NC_010498.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3600501 nanA 6142606 nanA Escherichia coli SMS-3-5 N-acetylneuraminate lyase YP_001745496.1 3599608 R 439855 CDS YP_001745497.1 170679875 6144733 complement(3600623..3601405) 1 NC_010498.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3601405 nanR 6144733 nanR Escherichia coli SMS-3-5 transcriptional regulator NanR YP_001745497.1 3600623 R 439855 CDS YP_001745498.1 170681874 6144037 3601794..3603161 1 NC_010498.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3603161 6144037 EcSMS35_3522 Escherichia coli SMS-3-5 putative cryptic C4-dicarboxylate transporter DcuD YP_001745498.1 3601794 D 439855 CDS YP_001745499.1 170681406 6146068 complement(3603205..3603702) 1 NC_010498.1 identified by match to protein family HMM PF04386; ClpXP protease specificity-enhancing factor 3603702 sspB 6146068 sspB Escherichia coli SMS-3-5 ClpXP protease specificity-enhancing factor YP_001745499.1 3603205 R 439855 CDS YP_001745500.1 170680756 6145590 complement(3603708..3604346) 1 NC_010498.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3604346 sspA 6145590 sspA Escherichia coli SMS-3-5 stringent starvation protein A YP_001745500.1 3603708 R 439855 CDS YP_001745501.1 170682369 6144931 3604600..3604743 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3604743 6144931 EcSMS35_3526 Escherichia coli SMS-3-5 hypothetical protein YP_001745501.1 3604600 D 439855 CDS YP_001745502.1 170682792 6146568 complement(3604740..3605132) 1 NC_010498.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3605132 rpsI 6146568 rpsI Escherichia coli SMS-3-5 30S ribosomal protein S9 YP_001745502.1 3604740 R 439855 CDS YP_001745503.1 170681781 6147001 complement(3605148..3605576) 1 NC_010498.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3605576 rplM 6147001 rplM Escherichia coli SMS-3-5 50S ribosomal protein L13 YP_001745503.1 3605148 R 439855 CDS YP_001745504.1 170683950 6145973 complement(3605795..3606922) 1 NC_010498.1 identified by match to protein family HMM PF03969; AFG1 family ATPase 3606922 6145973 EcSMS35_3528 Escherichia coli SMS-3-5 AFG1 family ATPase YP_001745504.1 3605795 R 439855 CDS YP_001745505.1 170683379 6143247 3607116..3607514 1 NC_010498.1 identified by match to protein family HMM PF06295; cytochrome d ubiquinol oxidase subunit III 3607514 6143247 EcSMS35_3529 Escherichia coli SMS-3-5 cytochrome d ubiquinol oxidase subunit III YP_001745505.1 3607116 D 439855 CDS YP_001745506.1 170682050 6142665 3607668..3609035 1 NC_010498.1 identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; serine endoprotease 3609035 degQ 6142665 degQ Escherichia coli SMS-3-5 serine endoprotease YP_001745506.1 3607668 D 439855 CDS YP_001745507.1 170683919 6146247 3609125..3610192 1 NC_010498.1 identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02038; serine endoprotease 3610192 degS 6146247 degS Escherichia coli SMS-3-5 serine endoprotease YP_001745507.1 3609125 D 439855 CDS YP_001745508.1 170681278 6143215 complement(3610255..3611193) 1 NC_010498.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3611193 mdh 6143215 mdh Escherichia coli SMS-3-5 malate dehydrogenase YP_001745508.1 3610255 R 439855 CDS YP_001745509.1 170682546 6145462 3611628..3612098 1 NC_010498.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3612098 argR 6145462 argR Escherichia coli SMS-3-5 arginine repressor YP_001745509.1 3611628 D 439855 CDS YP_001745510.1 170683417 6146747 3612463..3612726 1 NC_010498.1 identified by match to protein family HMM PF07338; protein YcfR 3612726 ycfR 6146747 ycfR Escherichia coli SMS-3-5 protein YcfR YP_001745510.1 3612463 D 439855 CDS YP_001745511.1 170680425 6142703 complement(3612782..3613054) 1 NC_010498.1 hypothetical protein 3613054 6142703 EcSMS35_3535 Escherichia coli SMS-3-5 hypothetical protein YP_001745511.1 3612782 R 439855 CDS YP_001745512.1 170682336 6144594 complement(3613146..3615113) 1 NC_010498.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3615113 aaeB 6144594 aaeB Escherichia coli SMS-3-5 p-hydroxybenzoic acid efflux subunit AaeB YP_001745512.1 3613146 R 439855 CDS YP_001745513.1 170683027 6146535 complement(3615119..3616051) 1 NC_010498.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3616051 aaeA 6146535 aaeA Escherichia coli SMS-3-5 p-hydroxybenzoic acid efflux subunit AaeA YP_001745513.1 3615119 R 439855 CDS YP_001745514.1 170683446 6147243 complement(3616059..3616331) 1 NC_010498.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3616331 aaeX 6147243 aaeX Escherichia coli SMS-3-5 hypothetical protein YP_001745514.1 3616059 R 439855 CDS YP_001745515.1 170684070 6142733 3616445..3617374 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 3617374 aaeR 6142733 aaeR Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001745515.1 3616445 D 439855 CDS YP_001745516.1 170680441 6143370 complement(3617502..3618947) 1 NC_010498.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3618947 tldD 6143370 tldD Escherichia coli SMS-3-5 protease TldD YP_001745516.1 3617502 R 439855 CDS YP_001745517.1 170683155 6144610 complement(3619103..3622903) 1 NC_010498.1 yhdP; identified by match to protein family HMM TIGR02099; hypothetical protein 3622903 6144610 EcSMS35_3541 Escherichia coli SMS-3-5 hypothetical protein YP_001745517.1 3619103 R 439855 CDS YP_001745518.1 170679965 6147375 complement(3622971..3624440) 1 NC_010498.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3624440 cafA 6147375 cafA Escherichia coli SMS-3-5 ribonuclease G YP_001745518.1 3622971 R 439855 CDS YP_001745519.1 170679685 6144127 complement(3624430..3625023) 1 NC_010498.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3625023 maf1 6144127 maf1 Escherichia coli SMS-3-5 Maf-like protein YP_001745519.1 3624430 R 439855 CDS YP_001745520.1 170683272 6143843 complement(3625032..3625520) 1 NC_010498.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3625520 lytS 6143843 lytS Escherichia coli SMS-3-5 rod shape-determining protein MreD YP_001745520.1 3625032 R 439855 CDS YP_001745521.1 170680238 6147497 complement(3625520..3626623) 1 NC_010498.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3626623 mreC 6147497 mreC Escherichia coli SMS-3-5 rod shape-determining protein MreC YP_001745521.1 3625520 R 439855 CDS YP_001745522.1 170684309 6144405 complement(3626689..3627732) 1 NC_010498.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3627732 mreB 6144405 mreB Escherichia coli SMS-3-5 rod shape-determining protein MreB YP_001745522.1 3626689 R 439855 CDS YP_001745523.1 170679868 6143611 complement(3628037..3629977) 1 NC_010498.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3629977 6143611 EcSMS35_3547 Escherichia coli SMS-3-5 regulatory protein CsrD YP_001745523.1 3628037 R 439855 CDS YP_001745524.1 170682984 6144030 3630129..3631103 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02823; quinone oxidoreductase 3631103 6144030 EcSMS35_3548 Escherichia coli SMS-3-5 quinone oxidoreductase YP_001745524.1 3630129 D 439855 CDS YP_001745525.1 170681262 6147200 3631140..3631970 1 NC_010498.1 hypothetical protein 3631970 6147200 EcSMS35_3549 Escherichia coli SMS-3-5 hypothetical protein YP_001745525.1 3631140 D 439855 CDS YP_001745526.1 170680327 6145446 3632836..3633306 1 NC_010498.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3633306 accB 6145446 accB Escherichia coli SMS-3-5 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_001745526.1 3632836 D 439855 CDS YP_001745527.1 170683611 6144495 3633317..3634666 1 NC_010498.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3634666 accC 6144495 accC Escherichia coli SMS-3-5 acetyl-CoA carboxylase biotin carboxylase subunit YP_001745527.1 3633317 D 439855 CDS YP_001745528.1 170681333 6142901 3634775..3635017 1 NC_010498.1 identified by match to protein family HMM PF06196; hypothetical protein 3635017 6142901 EcSMS35_3552 Escherichia coli SMS-3-5 hypothetical protein YP_001745528.1 3634775 D 439855 CDS YP_001745529.1 170679603 6145517 3635007..3636458 1 NC_010498.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3636458 panF 6145517 panF Escherichia coli SMS-3-5 sodium/panthothenate symporter YP_001745529.1 3635007 D 439855 CDS YP_001745530.1 170682751 6143760 3636470..3637351 1 NC_010498.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3637351 prmA 6143760 prmA Escherichia coli SMS-3-5 ribosomal protein L11 methyltransferase YP_001745530.1 3636470 D 439855 CDS YP_001745531.1 170680881 6146960 3637680..3638645 1 NC_010498.1 identified by match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 3638645 dusB 6146960 dusB Escherichia coli SMS-3-5 tRNA-dihydrouridine synthase B YP_001745531.1 3637680 D 439855 CDS YP_001745532.1 170682316 6145059 3638671..3638967 1 NC_010498.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3638967 fis 6145059 fis Escherichia coli SMS-3-5 DNA-binding protein Fis YP_001745532.1 3638671 D 439855 CDS YP_001745533.1 170680849 6146515 3639053..3639937 1 NC_010498.1 identified by match to protein family HMM PF01555; putative methyltransferase 3639937 6146515 EcSMS35_3557 Escherichia coli SMS-3-5 putative methyltransferase YP_001745533.1 3639053 D 439855 CDS YP_001745534.1 170682462 6145026 3640087..3640200 1 NC_010498.1 hypothetical protein 3640200 6145026 EcSMS35_3558 Escherichia coli SMS-3-5 hypothetical protein YP_001745534.1 3640087 D 439855 CDS YP_001745535.1 170683693 6146661 complement(3640203..3640865) 1 NC_010498.1 identified by match to protein family HMM PF00440; match to protein family HMM PF08361; DNA-binding transcriptional regulator EnvR 3640865 6146661 EcSMS35_3559 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator EnvR YP_001745535.1 3640203 R 439855 CDS YP_001745536.1 170683539 6142985 3641264..3642421 1 NC_010498.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; acriflavine resistance protein E 3642421 acrE 6142985 acrE Escherichia coli SMS-3-5 acriflavine resistance protein E YP_001745536.1 3641264 D 439855 CDS YP_001745537.1 170681493 6144794 3645783..3646004 1 NC_010498.1 putative lipoprotein 3646004 6144794 EcSMS35_3562 Escherichia coli SMS-3-5 putative lipoprotein YP_001745537.1 3645783 D 439855 CDS YP_001745538.1 170682914 6145678 3646435..3647460 1 NC_010498.1 amino acid ABC transporter periplasmic amino acid-binding protein 3647460 6145678 EcSMS35_3563 Escherichia coli SMS-3-5 amino acid ABC transporter periplasmic amino acid-binding protein YP_001745538.1 3646435 D 439855 CDS YP_001745539.1 170682235 6147128 3647528..3648709 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; His/Glu/Gln/Arg/opine ABC transporter permease 3648709 6147128 EcSMS35_3564 Escherichia coli SMS-3-5 His/Glu/Gln/Arg/opine ABC transporter permease YP_001745539.1 3647528 D 439855 CDS YP_001745540.1 170684312 6146434 3648719..3649822 1 NC_010498.1 yhdY; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; His/Glu/Gln/Arg/opine ABC transporter permease 3649822 6146434 EcSMS35_3565 Escherichia coli SMS-3-5 His/Glu/Gln/Arg/opine ABC transporter permease YP_001745540.1 3648719 D 439855 CDS YP_001745541.1 170680424 6143614 3649830..3650588 1 NC_010498.1 identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 3650588 6143614 EcSMS35_3566 Escherichia coli SMS-3-5 amino acid ABC transporter ATP-binding protein YP_001745541.1 3649830 D 439855 CDS YP_001745542.1 170681930 6143727 3656471..3657025 1 NC_010498.1 hypothetical protein 3657025 6143727 EcSMS35_3576 Escherichia coli SMS-3-5 hypothetical protein YP_001745542.1 3656471 D 439855 CDS YP_001745543.1 170681761 6146126 complement(3657001..3657258) 1 NC_010498.1 identified by match to protein family HMM PF07369; hypothetical protein 3657258 6146126 EcSMS35_3575 Escherichia coli SMS-3-5 hypothetical protein YP_001745543.1 3657001 R 439855 CDS YP_001745544.1 170682537 6145952 complement(3657255..3658073) 1 NC_010498.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3658073 aroE 6145952 aroE Escherichia coli SMS-3-5 shikimate 5-dehydrogenase YP_001745544.1 3657255 R 439855 CDS YP_001745545.1 170683354 6146738 complement(3658078..3658650) 1 NC_010498.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor 3658650 6146738 EcSMS35_3578 Escherichia coli SMS-3-5 putative ribosome maturation factor YP_001745545.1 3658078 R 439855 CDS YP_001745546.1 170683861 6142640 complement(3658655..3659197) 1 NC_010498.1 identified by match to protein family HMM PF01396; topoisomerase DNA-binding C4 zinc finger domain-containing protein 3659197 6142640 EcSMS35_3579 Escherichia coli SMS-3-5 topoisomerase DNA-binding C4 zinc finger domain-containing protein YP_001745546.1 3658655 R 439855 CDS YP_001745547.1 170679842 6143156 complement(3659226..3659699) 1 NC_010498.1 identified by match to protein family HMM PF04361; hypothetical protein 3659699 smg 6143156 smg Escherichia coli SMS-3-5 hypothetical protein YP_001745547.1 3659226 R 439855 CDS YP_001745548.1 170681650 6144004 complement(3659671..3660795) 1 NC_010498.1 identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA 3660795 dprA 6144004 dprA Escherichia coli SMS-3-5 DNA protecting protein DprA YP_001745548.1 3659671 R 439855 CDS YP_001745549.1 170680840 6145836 3660925..3661434 1 NC_010498.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3661434 def 6145836 def Escherichia coli SMS-3-5 peptide deformylase YP_001745549.1 3660925 D 439855 CDS YP_001745550.1 170682749 6145017 3661449..3662396 1 NC_010498.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3662396 fmt 6145017 fmt Escherichia coli SMS-3-5 methionyl-tRNA formyltransferase YP_001745550.1 3661449 D 439855 CDS YP_001745551.1 170684100 6146958 3662442..3663731 1 NC_010498.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3663731 rsmB 6146958 rsmB Escherichia coli SMS-3-5 16S rRNA methyltransferase B YP_001745551.1 3662442 D 439855 CDS YP_001745552.1 170680013 6143400 3663753..3665129 1 NC_010498.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3665129 trkA 6143400 trkA Escherichia coli SMS-3-5 potassium transporter peripheral membrane component YP_001745552.1 3663753 D 439855 CDS YP_001745553.1 170680177 6144176 3665259..3665669 1 NC_010498.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3665669 mscL 6144176 mscL Escherichia coli SMS-3-5 large-conductance mechanosensitive channel YP_001745553.1 3665259 D 439855 CDS YP_001745554.1 170680832 6144343 complement(3665940..3666365) 1 NC_010498.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3666365 zntR 6144343 zntR Escherichia coli SMS-3-5 zinc-responsive transcriptional regulator YP_001745554.1 3665940 R 439855 CDS YP_001745555.1 170682418 6145009 complement(3666376..3666744) 1 NC_010498.1 hypothetical protein 3666744 6145009 EcSMS35_3588 Escherichia coli SMS-3-5 hypothetical protein YP_001745555.1 3666376 R 439855 CDS YP_001745556.1 170682965 6146617 complement(3666851..3667234) 1 NC_010498.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3667234 rplQ 6146617 rplQ Escherichia coli SMS-3-5 50S ribosomal protein L17 YP_001745556.1 3666851 R 439855 CDS YP_001745557.1 170683426 6147180 complement(3667275..3668264) 1 NC_010498.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3668264 rpoA 6147180 rpoA Escherichia coli SMS-3-5 DNA-directed RNA polymerase subunit alpha YP_001745557.1 3667275 R 439855 CDS YP_001745558.1 170683332 6142713 complement(3668290..3668910) 1 NC_010498.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3668910 rpsD 6142713 rpsD Escherichia coli SMS-3-5 30S ribosomal protein S4 YP_001745558.1 3668290 R 439855 CDS YP_001745559.1 170679818 6142617 complement(3668944..3669333) 1 NC_010498.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3669333 rpsK 6142617 rpsK Escherichia coli SMS-3-5 30S ribosomal protein S11 YP_001745559.1 3668944 R 439855 CDS YP_001745560.1 170683249 6143979 complement(3669350..3669706) 1 NC_010498.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3669706 rpsM 6143979 rpsM Escherichia coli SMS-3-5 30S ribosomal protein S13 YP_001745560.1 3669350 R 439855 CDS YP_001745561.1 170682559 6147472 complement(3669853..3669969) 1 NC_010498.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3669969 rpmJ 6147472 rpmJ Escherichia coli SMS-3-5 50S ribosomal protein L36 YP_001745561.1 3669853 R 439855 CDS YP_001745562.1 170681949 6146762 complement(3670001..3671332) 1 NC_010498.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3671332 secY 6146762 secY Escherichia coli SMS-3-5 preprotein translocase subunit SecY YP_001745562.1 3670001 R 439855 CDS YP_001745563.1 170683231 6146145 complement(3671340..3671774) 1 NC_010498.1 late assembly protein; 50S ribosomal protein L15 3671774 rplO 6146145 rplO Escherichia coli SMS-3-5 50S ribosomal protein L15 YP_001745563.1 3671340 R 439855 CDS YP_001745564.1 170683915 6147452 complement(3671778..3671957) 1 NC_010498.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3671957 rpmD 6147452 rpmD Escherichia coli SMS-3-5 50S ribosomal protein L30 YP_001745564.1 3671778 R 439855 CDS YP_001745565.1 170679847 6143211 complement(3671961..3672464) 1 NC_010498.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3672464 rpsE 6143211 rpsE Escherichia coli SMS-3-5 30S ribosomal protein S5 YP_001745565.1 3671961 R 439855 CDS YP_001745566.1 170680518 6144009 complement(3672479..3672832) 1 NC_010498.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3672832 rplR 6144009 rplR Escherichia coli SMS-3-5 50S ribosomal protein L18 YP_001745566.1 3672479 R 439855 CDS YP_001745567.1 170680532 6144688 complement(3672842..3673375) 1 NC_010498.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3673375 rplF 6144688 rplF Escherichia coli SMS-3-5 50S ribosomal protein L6 YP_001745567.1 3672842 R 439855 CDS YP_001745568.1 170681247 6144702 complement(3673388..3673780) 1 NC_010498.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3673780 rpsH 6144702 rpsH Escherichia coli SMS-3-5 30S ribosomal protein S8 YP_001745568.1 3673388 R 439855 CDS YP_001745569.1 170681893 6145431 complement(3673814..3674119) 1 NC_010498.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3674119 rpsN 6145431 rpsN Escherichia coli SMS-3-5 30S ribosomal protein S14 YP_001745569.1 3673814 R 439855 CDS YP_001745570.1 170683635 6146087 complement(3674134..3674673) 1 NC_010498.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3674673 rplE 6146087 rplE Escherichia coli SMS-3-5 50S ribosomal protein L5 YP_001745570.1 3674134 R 439855 CDS YP_001745571.1 170682364 6142926 complement(3674688..3675002) 1 NC_010498.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3675002 rplX 6142926 rplX Escherichia coli SMS-3-5 50S ribosomal protein L24 YP_001745571.1 3674688 R 439855 CDS YP_001745572.1 170682900 6146563 complement(3675013..3675384) 1 NC_010498.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3675384 rplN 6146563 rplN Escherichia coli SMS-3-5 50S ribosomal protein L14 YP_001745572.1 3675013 R 439855 CDS YP_001745573.1 170681006 6147113 complement(3675549..3675803) 1 NC_010498.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3675803 rpsQ 6147113 rpsQ Escherichia coli SMS-3-5 30S ribosomal protein S17 YP_001745573.1 3675549 R 439855 CDS YP_001745574.1 170681520 6145187 complement(3675803..3675994) 1 NC_010498.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3675994 rpmC 6145187 rpmC Escherichia coli SMS-3-5 50S ribosomal protein L29 YP_001745574.1 3675803 R 439855 CDS YP_001745575.1 170680184 6145705 complement(3675994..3676404) 1 NC_010498.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3676404 rplP 6145705 rplP Escherichia coli SMS-3-5 50S ribosomal protein L16 YP_001745575.1 3675994 R 439855 CDS YP_001745576.1 170683377 6144350 complement(3676417..3677118) 1 NC_010498.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3677118 rpsC 6144350 rpsC Escherichia coli SMS-3-5 30S ribosomal protein S3 YP_001745576.1 3676417 R 439855 CDS YP_001745577.1 170683646 6142663 complement(3677136..3677468) 1 NC_010498.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3677468 rplV 6142663 rplV Escherichia coli SMS-3-5 50S ribosomal protein L22 YP_001745577.1 3677136 R 439855 CDS YP_001745578.1 170682027 6142938 complement(3677483..3677761) 1 NC_010498.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3677761 rpsS 6142938 rpsS Escherichia coli SMS-3-5 30S ribosomal protein S19 YP_001745578.1 3677483 R 439855 CDS YP_001745579.1 170683086 6146224 complement(3677778..3678599) 1 NC_010498.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3678599 rplB 6146224 rplB Escherichia coli SMS-3-5 50S ribosomal protein L2 YP_001745579.1 3677778 R 439855 CDS YP_001745580.1 170681042 6147303 complement(3678617..3678919) 1 NC_010498.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3678919 rplW 6147303 rplW Escherichia coli SMS-3-5 50S ribosomal protein L23 YP_001745580.1 3678617 R 439855 CDS YP_001745581.1 170679638 6145223 complement(3678916..3679521) 1 NC_010498.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3679521 rplD 6145223 rplD Escherichia coli SMS-3-5 50S ribosomal protein L4 YP_001745581.1 3678916 R 439855 CDS YP_001745582.1 170680319 6143795 complement(3679532..3680161) 1 NC_010498.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3680161 rplC 6143795 rplC Escherichia coli SMS-3-5 50S ribosomal protein L3 YP_001745582.1 3679532 R 439855 CDS YP_001745583.1 170683626 6144487 complement(3680194..3680505) 1 NC_010498.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3680505 rpsJ 6144487 rpsJ Escherichia coli SMS-3-5 30S ribosomal protein S10 YP_001745583.1 3680194 R 439855 CDS YP_001745584.1 170682251 6142917 3680884..3681351 1 NC_010498.1 identified by match to protein family HMM PF01478; A24 family peptidase 3681351 6142917 EcSMS35_3618 Escherichia coli SMS-3-5 A24 family peptidase YP_001745584.1 3680884 D 439855 CDS YP_001745585.1 170684300 6146450 complement(3681348..3681824) 1 NC_010498.1 iron storage protein; bacterioferritin 3681824 bfr 6146450 bfr Escherichia coli SMS-3-5 bacterioferritin YP_001745585.1 3681348 R 439855 CDS YP_001745586.1 170682920 6143602 complement(3681897..3682091) 1 NC_010498.1 identified by match to protein family HMM PF04324; bacterioferritin-associated ferredoxin 3682091 bfd 6143602 bfd Escherichia coli SMS-3-5 bacterioferritin-associated ferredoxin YP_001745586.1 3681897 R 439855 CDS YP_001745587.1 170681311 6147134 complement(3682274..3683458) 1 NC_010498.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3683458 tuf2 6147134 tuf2 Escherichia coli SMS-3-5 elongation factor Tu YP_001745587.1 3682274 R 439855 CDS YP_001745588.1 170681744 6145495 complement(3683529..3685643) 1 NC_010498.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3685643 fusA 6145495 fusA Escherichia coli SMS-3-5 elongation factor G YP_001745588.1 3683529 R 439855 CDS YP_001745589.1 170680064 6145934 complement(3685740..3686210) 1 NC_010498.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3686210 rpsG 6145934 rpsG Escherichia coli SMS-3-5 30S ribosomal protein S7 YP_001745589.1 3685740 R 439855 CDS YP_001745590.1 170683246 6144228 complement(3686307..3686681) 1 NC_010498.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3686681 rpsL 6144228 rpsL Escherichia coli SMS-3-5 30S ribosomal protein S12 YP_001745590.1 3686307 R 439855 CDS YP_001745591.1 170682708 6147469 complement(3686807..3687094) 1 NC_010498.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3687094 dsrH 6147469 dsrH Escherichia coli SMS-3-5 sulfur transfer complex subunit TusB YP_001745591.1 3686807 R 439855 CDS YP_001745592.1 170682208 6146916 complement(3687102..3687461) 1 NC_010498.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3687461 tusC 6146916 tusC Escherichia coli SMS-3-5 sulfur relay protein TusC YP_001745592.1 3687102 R 439855 CDS YP_001745593.1 170681621 6146407 complement(3687461..3687847) 1 NC_010498.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3687847 tusD 6146407 tusD Escherichia coli SMS-3-5 sulfur transfer complex subunit TusD YP_001745593.1 3687461 R 439855 CDS YP_001745594.1 170681109 6145806 complement(3687847..3688569) 1 NC_010498.1 identified by match to protein family HMM PF08348; hypothetical protein 3688569 6145806 EcSMS35_3627 Escherichia coli SMS-3-5 hypothetical protein YP_001745594.1 3687847 R 439855 CDS YP_001745595.1 170680696 6145292 complement(3688736..3689548) 1 NC_010498.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3689548 fkpA 6145292 fkpA Escherichia coli SMS-3-5 FKBP-type peptidyl-prolyl cis-trans isomerase YP_001745595.1 3688736 R 439855 CDS YP_001745596.1 170683809 6144871 3689769..3689987 1 NC_010498.1 identified by match to protein family HMM PF04102; hypothetical protein 3689987 6144871 EcSMS35_3629 Escherichia coli SMS-3-5 hypothetical protein YP_001745596.1 3689769 D 439855 CDS YP_001745597.1 170683250 6143103 complement(3690037..3690627) 1 NC_010498.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3690627 slyD 6143103 slyD Escherichia coli SMS-3-5 FKBP-type peptidyl-prolyl cis-trans isomerase YP_001745597.1 3690037 R 439855 CDS YP_001745598.1 170682580 6147473 complement(3690722..3690922) 1 NC_010498.1 identified by match to protein family HMM TIGR02443; hypothetical protein 3690922 6147473 EcSMS35_3631 Escherichia coli SMS-3-5 hypothetical protein YP_001745598.1 3690722 R 439855 CDS YP_001745599.1 170682213 6146785 complement(3690932..3692737) 1 NC_010498.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3692737 kefB 6146785 kefB Escherichia coli SMS-3-5 glutathione-regulated potassium-efflux system protein KefB YP_001745599.1 3690932 R 439855 CDS YP_001745600.1 170684014 6146412 complement(3692737..3693288) 1 NC_010498.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3693288 kefG 6146412 kefG Escherichia coli SMS-3-5 glutathione-regulated potassium-efflux system ancillary protein KefG YP_001745600.1 3692737 R 439855 CDS YP_001745601.1 170679823 6143313 3693419..3695332 1 NC_010498.1 identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein 3695332 6143313 EcSMS35_3634 Escherichia coli SMS-3-5 putative ABC transporter ATP-binding protein YP_001745601.1 3693419 D 439855 CDS YP_001745602.1 170683037 6143985 3695332..3696354 1 NC_010498.1 identified by match to protein family HMM PF00561; putative hydrolase 3696354 6143985 EcSMS35_3635 Escherichia coli SMS-3-5 putative hydrolase YP_001745602.1 3695332 D 439855 CDS YP_001745603.1 170683432 6147253 3696348..3696566 1 NC_010498.1 identified by match to protein family HMM PF06794; hypothetical protein 3696566 6147253 EcSMS35_3636 Escherichia coli SMS-3-5 hypothetical protein YP_001745603.1 3696348 D 439855 CDS YP_001745604.1 170683032 6142719 3696620..3697489 1 NC_010498.1 identified by match to protein family HMM PF00485; phosphoribulokinase/uridine kinase family protein 3697489 6142719 EcSMS35_3637 Escherichia coli SMS-3-5 phosphoribulokinase/uridine kinase family protein YP_001745604.1 3696620 D 439855 CDS YP_001745605.1 170682548 6147248 complement(3697544..3697948) 1 NC_010498.1 identified by match to protein family HMM PF02566; hypothetical protein 3697948 6147248 EcSMS35_3638 Escherichia coli SMS-3-5 hypothetical protein YP_001745605.1 3697544 R 439855 CDS YP_001745606.1 170681629 6146750 3698250..3698882 1 NC_010498.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3698882 crp 6146750 crp Escherichia coli SMS-3-5 cAMP-regulatory protein YP_001745606.1 3698250 D 439855 CDS YP_001745607.1 170682476 6145814 3698933..3701023 1 NC_010498.1 identified by match to protein family HMM PF05976; match to protein family HMM TIGR01667; YccS/YhfK family integral membrane protein 3701023 6145814 EcSMS35_3640 Escherichia coli SMS-3-5 YccS/YhfK family integral membrane protein YP_001745607.1 3698933 D 439855 CDS YP_001745608.1 170679794 6146675 complement(3701086..3702309) 1 NC_010498.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 3702309 argD 6146675 argD Escherichia coli SMS-3-5 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein YP_001745608.1 3701086 R 439855 CDS YP_001745609.1 170680557 6143954 complement(3702395..3702958) 1 NC_010498.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3702958 pabA 6143954 pabA Escherichia coli SMS-3-5 para-aminobenzoate synthase component II YP_001745609.1 3702395 R 439855 CDS YP_001745610.1 170681998 6144727 complement(3702990..3703592) 1 NC_010498.1 identified by match to protein family HMM PF02661; cell filamentation protein Fic 3703592 fic 6144727 fic Escherichia coli SMS-3-5 cell filamentation protein Fic YP_001745610.1 3702990 R 439855 CDS YP_001745611.1 170681864 6146194 complement(3703854..3704426) 1 NC_010498.1 identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase A (rotamase A) 3704426 ppiA 6146194 ppiA Escherichia coli SMS-3-5 peptidyl-prolyl cis-trans isomerase A (rotamase A) YP_001745611.1 3703854 R 439855 CDS YP_001745612.1 170682492 6146058 complement(3704570..3704716) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3704716 6146058 EcSMS35_3645 Escherichia coli SMS-3-5 hypothetical protein YP_001745612.1 3704570 R 439855 CDS YP_001745613.1 170682755 6146691 3704697..3705878 1 NC_010498.1 identified by match to protein family HMM PF07690; hypothetical protein 3705878 tsgA 6146691 tsgA Escherichia coli SMS-3-5 hypothetical protein YP_001745613.1 3704697 D 439855 CDS YP_001745614.1 170683252 6146964 3706140..3708683 1 NC_010498.1 identified by match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; match to protein family HMM PF07992; match to protein family HMM TIGR02374; nitrite reductase [NAD(P)H], large subunit 3708683 nirB 6146964 nirB Escherichia coli SMS-3-5 nitrite reductase [NAD(P)H], large subunit YP_001745614.1 3706140 D 439855 CDS YP_001745615.1 170684098 6147475 3708680..3709006 1 NC_010498.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3709006 nirD 6147475 nirD Escherichia coli SMS-3-5 nitrite reductase small subunit YP_001745615.1 3708680 D 439855 CDS YP_001745616.1 170683994 6143398 3709131..3709937 1 NC_010498.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3709937 nirC 6143398 nirC Escherichia coli SMS-3-5 nitrite transporter NirC YP_001745616.1 3709131 D 439855 CDS YP_001745617.1 170680692 6143292 3709956..3711329 1 NC_010498.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3711329 cysG 6143292 cysG Escherichia coli SMS-3-5 siroheme synthase YP_001745617.1 3709956 D 439855 CDS YP_001745618.1 170681033 6144867 3711580..3711747 1 NC_010498.1 putative lipoprotein 3711747 6144867 EcSMS35_3651 Escherichia coli SMS-3-5 putative lipoprotein YP_001745618.1 3711580 D 439855 CDS YP_001745619.1 170682063 6145214 complement(3711854..3712939) 1 NC_010498.1 identified by similarity to GB:ABF05423.1; hypothetical protein 3712939 6145214 EcSMS35_3652 Escherichia coli SMS-3-5 hypothetical protein YP_001745619.1 3711854 R 439855 CDS YP_001745620.1 170680136 6146260 complement(3712951..3714255) 1 NC_010498.1 hypothetical protein 3714255 6146260 EcSMS35_3653 Escherichia coli SMS-3-5 hypothetical protein YP_001745620.1 3712951 R 439855 CDS YP_001745621.1 170681101 6144302 complement(3714267..3714620) 1 NC_010498.1 hypothetical protein 3714620 6144302 EcSMS35_3654 Escherichia coli SMS-3-5 hypothetical protein YP_001745621.1 3714267 R 439855 CDS YP_001745622.1 170680454 6145283 complement(3714631..3715509) 1 NC_010498.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase 3715509 6145283 EcSMS35_3655 Escherichia coli SMS-3-5 putative hydrolase YP_001745622.1 3714631 R 439855 CDS YP_001745623.1 170680107 6144623 complement(3715506..3716732) 1 NC_010498.1 identified by match to protein family HMM PF01676; match to protein family HMM PF08342; putative mutase 3716732 6144623 EcSMS35_3656 Escherichia coli SMS-3-5 putative mutase YP_001745623.1 3715506 R 439855 CDS YP_001745624.1 170684172 6144271 complement(3716732..3717895) 1 NC_010498.1 identified by match to protein family HMM PF01168; alanine racemase 3717895 6144271 EcSMS35_3657 Escherichia coli SMS-3-5 alanine racemase YP_001745624.1 3716732 R 439855 CDS YP_001745625.1 170680031 6143473 complement(3717979..3718341) 1 NC_010498.1 hypothetical protein 3718341 6143473 EcSMS35_3658 Escherichia coli SMS-3-5 hypothetical protein YP_001745625.1 3717979 R 439855 CDS YP_001745626.1 170680763 6144194 complement(3718358..3719263) 1 NC_010498.1 hypothetical protein 3719263 6144194 EcSMS35_3659 Escherichia coli SMS-3-5 hypothetical protein YP_001745626.1 3718358 R 439855 CDS YP_001745627.1 170681086 6144938 complement(3719423..3720427) 1 NC_010498.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3720427 trpS 6144938 trpS Escherichia coli SMS-3-5 tryptophanyl-tRNA synthetase YP_001745627.1 3719423 R 439855 CDS YP_001745628.1 170681789 6145268 complement(3720420..3721178) 1 NC_010498.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3721178 gph 6145268 gph Escherichia coli SMS-3-5 phosphoglycolate phosphatase YP_001745628.1 3720420 R 439855 CDS YP_001745629.1 170680384 6145981 complement(3721171..3721848) 1 NC_010498.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3721848 rpe 6145981 rpe Escherichia coli SMS-3-5 ribulose-phosphate 3-epimerase YP_001745629.1 3721171 R 439855 CDS YP_001745630.1 170683954 6144553 complement(3721866..3722702) 1 NC_010498.1 identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; DNA adenine methylase 3722702 dam 6144553 dam Escherichia coli SMS-3-5 DNA adenine methylase YP_001745630.1 3721866 R 439855 CDS YP_001745631.1 170683150 6143251 complement(3722809..3724095) 1 NC_010498.1 identified by match to protein family HMM PF05036; hypothetical protein 3724095 damX 6143251 damX Escherichia coli SMS-3-5 hypothetical protein YP_001745631.1 3722809 R 439855 CDS YP_001745632.1 170680643 6147370 complement(3724187..3725275) 1 NC_010498.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3725275 aroB 6147370 aroB Escherichia coli SMS-3-5 3-dehydroquinate synthase YP_001745632.1 3724187 R 439855 CDS YP_001745633.1 170680023 6144818 complement(3725332..3726009) 1 NC_010498.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3726009 aroK 6144818 aroK Escherichia coli SMS-3-5 shikimate kinase I YP_001745633.1 3725332 R 439855 CDS YP_001745634.1 170681657 6144186 complement(3726254..3727492) 1 NC_010498.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 3727492 hofQ 6144186 hofQ Escherichia coli SMS-3-5 outer membrane porin HofQ YP_001745634.1 3726254 R 439855 CDS YP_001745635.1 170681152 6145843 complement(3727404..3727808) 1 NC_010498.1 hypothetical protein 3727808 6145843 EcSMS35_3668 Escherichia coli SMS-3-5 hypothetical protein YP_001745635.1 3727404 R 439855 CDS YP_001745636.1 170682127 6145335 complement(3727798..3727995) 1 NC_010498.1 hypothetical protein 3727995 6145335 EcSMS35_3669 Escherichia coli SMS-3-5 hypothetical protein YP_001745636.1 3727798 R 439855 CDS YP_001745637.1 170683769 6146326 3727981..3728100 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3728100 6146326 EcSMS35_3670 Escherichia coli SMS-3-5 hypothetical protein YP_001745637.1 3727981 D 439855 CDS YP_001745638.1 170683225 6143061 complement(3728222..3728761) 1 NC_010498.1 identified by match to protein family HMM PF05137; PilN family protein 3728761 6143061 EcSMS35_3671 Escherichia coli SMS-3-5 PilN family protein YP_001745638.1 3728222 R 439855 CDS YP_001745639.1 170680610 6147446 complement(3728761..3729540) 1 NC_010498.1 HofM protein 3729540 hofM 6147446 hofM Escherichia coli SMS-3-5 HofM protein YP_001745639.1 3728761 R 439855 CDS YP_001745640.1 170683444 6144784 3729636..3732212 1 NC_010498.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3732212 mrcA 6144784 mrcA Escherichia coli SMS-3-5 peptidoglycan synthetase YP_001745640.1 3729636 D 439855 CDS YP_001745641.1 170680526 6142731 complement(3732380..3732940) 1 NC_010498.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3732940 nudE 6142731 nudE Escherichia coli SMS-3-5 ADP-ribose diphosphatase NudE YP_001745641.1 3732380 R 439855 CDS YP_001745642.1 170680061 6144696 3733144..3733263 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3733263 6144696 EcSMS35_3675 Escherichia coli SMS-3-5 hypothetical protein YP_001745642.1 3733144 D 439855 CDS YP_001745643.1 170681885 6144225 3733260..3735395 1 NC_010498.1 identified by match to protein family HMM PF07095; hypothetical protein 3735395 6144225 EcSMS35_3676 Escherichia coli SMS-3-5 hypothetical protein YP_001745643.1 3733260 D 439855 CDS YP_001745644.1 170681347 6146079 3735460..3736128 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; HAD family hydrolase 3736128 6146079 EcSMS35_3677 Escherichia coli SMS-3-5 HAD family hydrolase YP_001745644.1 3735460 D 439855 CDS YP_001745645.1 170680851 6145531 3736139..3736540 1 NC_010498.1 identified by match to protein family HMM PF01479; ribosome-associated heat shock protein Hsp15 3736540 hslR 6145531 hslR Escherichia coli SMS-3-5 ribosome-associated heat shock protein Hsp15 YP_001745645.1 3736139 D 439855 CDS YP_001745646.1 170682746 6145028 3736565..3737443 1 NC_010498.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3737443 hslO 6145028 hslO Escherichia coli SMS-3-5 Hsp33-like chaperonin YP_001745646.1 3736565 D 439855 CDS YP_001745647.1 170682230 6146954 complement(3737577..3739301) 1 NC_010498.1 hypothetical protein 3739301 6146954 EcSMS35_3680 Escherichia coli SMS-3-5 hypothetical protein YP_001745647.1 3737577 R 439855 CDS YP_001745648.1 170684065 6146429 complement(3739307..3739435) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3739435 6146429 EcSMS35_3681 Escherichia coli SMS-3-5 hypothetical protein YP_001745648.1 3739307 R 439855 CDS YP_001745649.1 170683548 6143365 3739680..3741302 1 NC_010498.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3741302 pckA 6143365 pckA Escherichia coli SMS-3-5 phosphoenolpyruvate carboxykinase YP_001745649.1 3739680 D 439855 CDS YP_001745650.1 170682459 6142838 3741417..3741734 1 NC_010498.1 identified by similarity to GB:ABA72014.1; hypothetical protein 3741734 6142838 EcSMS35_3683 Escherichia coli SMS-3-5 hypothetical protein YP_001745650.1 3741417 D 439855 CDS YP_001745651.1 170680949 6146658 3741793..3742089 1 NC_010498.1 yiaG; identified by similarity to GB:CAE16739.1; hypothetical protein 3742089 6146658 EcSMS35_3684 Escherichia coli SMS-3-5 hypothetical protein YP_001745651.1 3741793 D 439855 CDS YP_001745652.1 170681185 6145130 complement(3742121..3743473) 1 NC_010498.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3743473 envZ 6145130 envZ Escherichia coli SMS-3-5 osmolarity sensor protein YP_001745652.1 3742121 R 439855 CDS YP_001745653.1 170679581 6145369 complement(3743470..3744189) 1 NC_010498.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3744189 ompR 6145369 ompR Escherichia coli SMS-3-5 osmolarity response regulator YP_001745653.1 3743470 R 439855 CDS YP_001745654.1 170680405 6143738 3744417..3744893 1 NC_010498.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3744893 greB 6143738 greB Escherichia coli SMS-3-5 transcription elongation factor GreB YP_001745654.1 3744417 D 439855 CDS YP_001745655.1 170683595 6144574 3744990..3747311 1 NC_010498.1 yhgF; identified by similarity to SP:P46837; match to protein family HMM PF00575; putative transcriptional accessory protein 3747311 6144574 EcSMS35_3688 Escherichia coli SMS-3-5 putative transcriptional accessory protein YP_001745655.1 3744990 D 439855 CDS YP_001745656.1 170683798 6142886 3747749..3747976 1 NC_010498.1 identified by similarity to SP:P0AEL3; match to protein family HMM PF04023; ferrous iron transport protein A 3747976 feoA 6142886 feoA Escherichia coli SMS-3-5 ferrous iron transport protein A YP_001745656.1 3747749 D 439855 CDS YP_001745657.1 170682365 6143091 3747993..3750314 1 NC_010498.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3750314 feoB 6143091 feoB Escherichia coli SMS-3-5 ferrous iron transport protein B YP_001745657.1 3747993 D 439855 CDS YP_001745658.1 170683053 6146564 3750314..3750550 1 NC_010498.1 identified by match to protein family HMM PF09012; hypothetical protein 3750550 6146564 EcSMS35_3691 Escherichia coli SMS-3-5 hypothetical protein YP_001745658.1 3750314 D 439855 CDS YP_001745659.1 170683554 6147269 3750753..3751631 1 NC_010498.1 identified by similarity to GB:AAP19288.1; match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 3751631 6147269 EcSMS35_3692 Escherichia coli SMS-3-5 hypothetical protein YP_001745659.1 3750753 D 439855 CDS YP_001745660.1 170680513 6142844 complement(3751660..3752430) 1 NC_010498.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3752430 6142844 EcSMS35_3693 Escherichia coli SMS-3-5 carboxylesterase BioH YP_001745660.1 3751660 R 439855 CDS YP_001745661.1 170681819 6144683 3752468..3753151 1 NC_010498.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3753151 gntX 6144683 gntX Escherichia coli SMS-3-5 gluconate periplasmic binding protein YP_001745661.1 3752468 D 439855 CDS YP_001745662.1 170681204 6146012 3753210..3753785 1 NC_010498.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3753785 gntY 6146012 gntY Escherichia coli SMS-3-5 putative DNA uptake protein YP_001745662.1 3753210 D 439855 CDS YP_001745663.1 170681024 6145388 3754146..3755462 1 NC_010498.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; high-affinity gluconate transporter 3755462 gntT 6145388 gntT Escherichia coli SMS-3-5 high-affinity gluconate transporter YP_001745663.1 3754146 D 439855 CDS YP_001745664.1 170682539 6145205 complement(3755507..3757591) 1 NC_010498.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3757591 malQ 6145205 malQ Escherichia coli SMS-3-5 4-alpha-glucanotransferase YP_001745664.1 3755507 R 439855 CDS YP_001745665.1 170683923 6146740 complement(3757601..3759994) 1 NC_010498.1 identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; maltodextrin phosphorylase 3759994 malP 6146740 malP Escherichia coli SMS-3-5 maltodextrin phosphorylase YP_001745665.1 3757601 R 439855 CDS YP_001745666.1 170683264 6143219 3760617..3763322 1 NC_010498.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3763322 malT 6143219 malT Escherichia coli SMS-3-5 transcriptional regulator MalT YP_001745666.1 3760617 D 439855 CDS YP_001745667.1 170680706 6147489 complement(3763365..3764381) 1 NC_010498.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3764381 rtcA 6147489 rtcA Escherichia coli SMS-3-5 RNA 3'-terminal-phosphate cyclase YP_001745667.1 3763365 R 439855 CDS YP_001745668.1 170679877 6144881 complement(3764385..3765611) 1 NC_010498.1 identified by match to protein family HMM PF01139; RtcB protein 3765611 rtcB 6144881 rtcB Escherichia coli SMS-3-5 RtcB protein YP_001745668.1 3764385 R 439855 CDS YP_001745669.1 170680280 6144039 3765799..3767397 1 NC_010498.1 identified by match to protein family HMM PF00158; match to protein family HMM PF06956; match to protein family HMM PF07728; sigma-54 dependent transcriptional regulator RtcR 3767397 rtcR 6144039 rtcR Escherichia coli SMS-3-5 sigma-54 dependent transcriptional regulator RtcR YP_001745669.1 3765799 D 439855 CDS YP_001745670.1 170683823 6144447 complement(3767379..3768137) 1 NC_010498.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3768137 glpR 6144447 glpR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor GlpR YP_001745670.1 3767379 R 439855 CDS YP_001745671.1 170683698 6143117 complement(3768154..3768984) 1 NC_010498.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3768984 6143117 EcSMS35_3704 Escherichia coli SMS-3-5 intramembrane serine protease GlpG YP_001745671.1 3768154 R 439855 CDS YP_001745672.1 170684232 6142990 complement(3769029..3769355) 1 NC_010498.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3769355 glpE 6142990 glpE Escherichia coli SMS-3-5 thiosulfate sulfurtransferase YP_001745672.1 3769029 R 439855 CDS YP_001745673.1 170682330 6143533 3769545..3771050 1 NC_010498.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3771050 glpD 6143533 glpD Escherichia coli SMS-3-5 glycerol-3-phosphate dehydrogenase YP_001745673.1 3769545 D 439855 CDS YP_001745674.1 170683549 6147059 complement(3771868..3772860) 1 NC_010498.1 hypothetical protein 3772860 6147059 EcSMS35_3708 Escherichia coli SMS-3-5 hypothetical protein YP_001745674.1 3771868 R 439855 CDS YP_001745675.1 170681684 6142839 complement(3772886..3774391) 1 NC_010498.1 hypothetical protein 3774391 6142839 EcSMS35_3709 Escherichia coli SMS-3-5 hypothetical protein YP_001745675.1 3772886 R 439855 CDS YP_001745676.1 170682143 6145870 complement(3774520..3776967) 1 NC_010498.1 identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase 3776967 glgP 6145870 glgP Escherichia coli SMS-3-5 glycogen phosphorylase YP_001745676.1 3774520 R 439855 CDS YP_001745677.1 170680998 6146342 complement(3776986..3778419) 1 NC_010498.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3778419 glgA 6146342 glgA Escherichia coli SMS-3-5 glycogen synthase YP_001745677.1 3776986 R 439855 CDS YP_001745678.1 170682122 6145179 complement(3778419..3779714) 1 NC_010498.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3779714 glgC 6145179 glgC Escherichia coli SMS-3-5 glucose-1-phosphate adenylyltransferase YP_001745678.1 3778419 R 439855 CDS YP_001745679.1 170679803 6146321 complement(3779732..3781705) 1 NC_010498.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 3781705 glgX 6146321 glgX Escherichia coli SMS-3-5 glycogen debranching enzyme YP_001745679.1 3779732 R 439855 CDS YP_001745680.1 170680453 6143963 complement(3781702..3783888) 1 NC_010498.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 3783888 glgB 6143963 glgB Escherichia coli SMS-3-5 glycogen branching enzyme YP_001745680.1 3781702 R 439855 CDS YP_001745681.1 170680367 6144622 complement(3784161..3785264) 1 NC_010498.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3785264 asd 6144622 asd Escherichia coli SMS-3-5 aspartate-semialdehyde dehydrogenase YP_001745681.1 3784161 R 439855 CDS YP_001745682.1 170679768 6144535 3785456..3786049 1 NC_010498.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 3786049 6144535 EcSMS35_3716 Escherichia coli SMS-3-5 putative dITP- and XTP- hydrolase YP_001745682.1 3785456 D 439855 CDS YP_001745683.1 170683496 6143927 complement(3786095..3787297) 1 NC_010498.1 identified by match to protein family HMM PF02481; putative DNA protecting protein DprA 3787297 6143927 EcSMS35_3717 Escherichia coli SMS-3-5 putative DNA protecting protein DprA YP_001745683.1 3786095 R 439855 CDS YP_001745684.1 170684175 6142785 complement(3787297..3789393) 1 NC_010498.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614; ATP-dependent DNA helicase RecQ 3789393 6142785 EcSMS35_3718 Escherichia coli SMS-3-5 ATP-dependent DNA helicase RecQ YP_001745684.1 3787297 R 439855 CDS YP_001745685.1 170680129 6143476 complement(3789533..3790873) 1 NC_010498.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; low affinity gluconate transporter 3790873 gntU 6143476 gntU Escherichia coli SMS-3-5 low affinity gluconate transporter YP_001745685.1 3789533 R 439855 CDS YP_001745686.1 170680239 6144294 complement(3790877..3791425) 1 NC_010498.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 3791425 gntK 6144294 gntK Escherichia coli SMS-3-5 gluconate kinase 1 YP_001745686.1 3790877 R 439855 CDS YP_001745687.1 170681394 6144406 complement(3791543..3792538) 1 NC_010498.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator GntR 3792538 gntR 6144406 gntR Escherichia coli SMS-3-5 transcriptional regulator GntR YP_001745687.1 3791543 R 439855 CDS YP_001745688.1 170681325 6145578 3792616..3792765 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3792765 6145578 EcSMS35_3723 Escherichia coli SMS-3-5 hypothetical protein YP_001745688.1 3792616 D 439855 CDS YP_001745689.1 170680488 6145509 complement(3792762..3793457) 1 NC_010498.1 identified by match to protein family HMM PF02678; match to protein family HMM PF07883; pirin family protein 3793457 6145509 EcSMS35_3722 Escherichia coli SMS-3-5 pirin family protein YP_001745689.1 3792762 R 439855 CDS YP_001745690.1 170681404 6144657 complement(3793580..3794617) 1 NC_010498.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894; putative dehydrogenase 3794617 6144657 EcSMS35_3724 Escherichia coli SMS-3-5 putative dehydrogenase YP_001745690.1 3793580 R 439855 CDS YP_001745691.1 170679976 6145588 3794951..3795439 1 NC_010498.1 YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 3795439 6145588 EcSMS35_3725 Escherichia coli SMS-3-5 putative acetyltransferase YhhY YP_001745691.1 3794951 D 439855 CDS YP_001745692.1 170680502 6144138 complement(3795500..3797245) 1 NC_010498.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3797245 ggt 6144138 ggt Escherichia coli SMS-3-5 gamma-glutamyltranspeptidase YP_001745692.1 3795500 R 439855 CDS YP_001745693.1 170683830 6144671 3797365..3797805 1 NC_010498.1 hypothetical protein 3797805 6144671 EcSMS35_3728 Escherichia coli SMS-3-5 hypothetical protein YP_001745693.1 3797365 D 439855 CDS YP_001745694.1 170683164 6143124 complement(3797792..3798535) 1 NC_010498.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase 3798535 ugpQ 6143124 ugpQ Escherichia coli SMS-3-5 cytoplasmic glycerophosphodiester phosphodiesterase YP_001745694.1 3797792 R 439855 CDS YP_001745695.1 170682930 6147384 complement(3798532..3799602) 1 NC_010498.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 3799602 ugpC 6147384 ugpC Escherichia coli SMS-3-5 glycerol-3-phosphate transporter ATP-binding subunit YP_001745695.1 3798532 R 439855 CDS YP_001745696.1 170682666 6147144 complement(3799604..3800449) 1 NC_010498.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3800449 6147144 EcSMS35_3730 Escherichia coli SMS-3-5 glycerol-3-phosphate transporter membrane protein YP_001745696.1 3799604 R 439855 CDS YP_001745697.1 170681862 6146873 complement(3800446..3801333) 1 NC_010498.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3801333 ugpA 6146873 ugpA Escherichia coli SMS-3-5 glycerol-3-phosphate transporter permease YP_001745697.1 3800446 R 439855 CDS YP_001745698.1 170680964 6146056 complement(3801431..3802747) 1 NC_010498.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 3802747 ugpB 6146056 ugpB Escherichia coli SMS-3-5 glycerol-3-phosphate transporter periplasmic binding protein YP_001745698.1 3801431 R 439855 CDS YP_001745699.1 170682293 6145145 complement(3802958..3803110) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3803110 6145145 EcSMS35_3733 Escherichia coli SMS-3-5 hypothetical protein YP_001745699.1 3802958 R 439855 CDS YP_001745700.1 170684156 6146492 complement(3803107..3803853) 1 NC_010498.1 hypothetical protein 3803853 6146492 EcSMS35_3734 Escherichia coli SMS-3-5 hypothetical protein YP_001745700.1 3803107 R 439855 CDS YP_001745701.1 170680178 6143456 3803852..3803983 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3803983 6143456 EcSMS35_3736 Escherichia coli SMS-3-5 hypothetical protein YP_001745701.1 3803852 D 439855 CDS YP_001745702.1 170683525 6144344 complement(3803972..3804685) 1 NC_010498.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3804685 livF 6144344 livF Escherichia coli SMS-3-5 leucine/isoleucine/valine transporter ATP-binding subunit YP_001745702.1 3803972 R 439855 CDS YP_001745703.1 170679813 6142815 complement(3804687..3805454) 1 NC_010498.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3805454 livG 6142815 livG Escherichia coli SMS-3-5 leucine/isoleucine/valine transporter ATP-binding subunit YP_001745703.1 3804687 R 439855 CDS YP_001745704.1 170681266 6143974 complement(3805451..3806728) 1 NC_010498.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 3806728 livM 6143974 livM Escherichia coli SMS-3-5 leucine/isoleucine/valine transporter permease subunit YP_001745704.1 3805451 R 439855 CDS YP_001745705.1 170680877 6145450 complement(3806725..3807651) 1 NC_010498.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 3807651 livH 6145450 livH Escherichia coli SMS-3-5 branched-chain amino acid transporter permease subunit LivH YP_001745705.1 3806725 R 439855 CDS YP_001745706.1 170683091 6145055 complement(3807699..3808808) 1 NC_010498.1 identified by match to protein family HMM PF01094; high-affinity branched-chain amino acid ABC transporter periplasmic leucine-specific-binding protein LivK 3808808 livK 6145055 livK Escherichia coli SMS-3-5 high-affinity branched-chain amino acid ABC transporter periplasmic leucine-specific-binding protein LivK YP_001745706.1 3807699 R 439855 CDS YP_001745707.1 170682480 6147309 complement(3808960..3809097) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3809097 6147309 EcSMS35_3741 Escherichia coli SMS-3-5 hypothetical protein YP_001745707.1 3808960 R 439855 CDS YP_001745708.1 170681379 6146679 3809232..3809615 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 3809615 6146679 EcSMS35_3742 Escherichia coli SMS-3-5 acetyltransferase YP_001745708.1 3809232 D 439855 CDS YP_001745709.1 170679864 6145563 complement(3809803..3810906) 1 NC_010498.1 identified by match to protein family HMM PF01094; high-affinity branched-chain amino acid ABC transporter periplasmic Leu/Ile/Val-binding protein LivJ 3810906 livJ 6145563 livJ Escherichia coli SMS-3-5 high-affinity branched-chain amino acid ABC transporter periplasmic Leu/Ile/Val-binding protein LivJ YP_001745709.1 3809803 R 439855 CDS YP_001745710.1 170683649 6144026 complement(3811178..3812032) 1 NC_010498.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3812032 rpoH 6144026 rpoH Escherichia coli SMS-3-5 RNA polymerase factor sigma-32 YP_001745710.1 3811178 R 439855 CDS YP_001745711.1 170684192 6142941 complement(3812277..3813335) 1 NC_010498.1 putative ABC transporter, membrane protein; cell division protein FtsX 3813335 ftsX 6142941 ftsX Escherichia coli SMS-3-5 cell division protein FtsX YP_001745711.1 3812277 R 439855 CDS YP_001745712.1 170684146 6143493 complement(3813328..3813996) 1 NC_010498.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3813996 ftsE 6143493 ftsE Escherichia coli SMS-3-5 cell division protein FtsE YP_001745712.1 3813328 R 439855 CDS YP_001745713.1 170682136 6143446 complement(3813999..3815537) 1 NC_010498.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3815537 ftsY 6143446 ftsY Escherichia coli SMS-3-5 cell division protein FtsY YP_001745713.1 3813999 R 439855 CDS YP_001745714.1 170683100 6146335 3815687..3816283 1 NC_010498.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3816283 rsmD 6146335 rsmD Escherichia coli SMS-3-5 16S rRNA m(2)G966-methyltransferase YP_001745714.1 3815687 D 439855 CDS YP_001745715.1 170681085 6147319 3816273..3816542 1 NC_010498.1 identified by match to protein family HMM PF06611; hypothetical protein 3816542 6147319 EcSMS35_3749 Escherichia coli SMS-3-5 hypothetical protein YP_001745715.1 3816273 D 439855 CDS YP_001745716.1 170680688 6145267 complement(3816545..3816904) 1 NC_010498.1 hypothetical protein 3816904 6145267 EcSMS35_3750 Escherichia coli SMS-3-5 hypothetical protein YP_001745716.1 3816545 R 439855 CDS YP_001745717.1 170683538 6144863 3817045..3817671 1 NC_010498.1 identified by match to protein family HMM PF07947; hypothetical protein 3817671 6144863 EcSMS35_3751 Escherichia coli SMS-3-5 hypothetical protein YP_001745717.1 3817045 D 439855 CDS YP_001745718.1 170683459 6142828 3817745..3819943 1 NC_010498.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3819943 zntA 6142828 zntA Escherichia coli SMS-3-5 zinc/cadmium/mercury/lead-transporting ATPase YP_001745718.1 3817745 D 439855 CDS YP_001745719.1 170684194 6142747 complement(3819976..3820284) 1 NC_010498.1 identified by similarity to GB:ABL00817.1; hypothetical protein 3820284 6142747 EcSMS35_3753 Escherichia coli SMS-3-5 hypothetical protein YP_001745719.1 3819976 R 439855 CDS YP_001745720.1 170682812 6143495 complement(3820499..3820744) 1 NC_010498.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3820744 tusA 6143495 tusA Escherichia coli SMS-3-5 sulfur transfer protein SirA YP_001745720.1 3820499 R 439855 CDS YP_001745721.1 170682902 6147023 3820965..3821630 1 NC_010498.1 identified by match to protein family HMM PF02592; match to protein family HMM TIGR00697; hypothetical protein 3821630 6147023 EcSMS35_3755 Escherichia coli SMS-3-5 hypothetical protein YP_001745721.1 3820965 D 439855 CDS YP_001745722.1 170680804 6147115 3821703..3822260 1 NC_010498.1 hypothetical protein 3822260 6147115 EcSMS35_3756 Escherichia coli SMS-3-5 hypothetical protein YP_001745722.1 3821703 D 439855 CDS YP_001745723.1 170681523 6144980 complement(3822264..3823514) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator superfamily transporter 3823514 6144980 EcSMS35_3757 Escherichia coli SMS-3-5 major facilitator superfamily transporter YP_001745723.1 3822264 R 439855 CDS YP_001745724.1 170679689 6145708 3823613..3824662 1 NC_010498.1 identified by match to protein family HMM PF01594; hypothetical protein 3824662 6145708 EcSMS35_3758 Escherichia coli SMS-3-5 hypothetical protein YP_001745724.1 3823613 D 439855 CDS YP_001745725.1 170680191 6143847 3824717..3825304 1 NC_010498.1 identified by match to protein family HMM PF01648; holo-(acyl carrier protein) synthase 2 3825304 acpT 6143847 acpT Escherichia coli SMS-3-5 holo-(acyl carrier protein) synthase 2 YP_001745725.1 3824717 D 439855 CDS YP_001745726.1 170684038 6144357 3825415..3826989 1 NC_010498.1 identified by match to protein family HMM PF00496; match to protein family HMM TIGR02294; nickel ABC transporter periplasmic nickel-binding protein NikA 3826989 nikA 6144357 nikA Escherichia coli SMS-3-5 nickel ABC transporter periplasmic nickel-binding protein NikA YP_001745726.1 3825415 D 439855 CDS YP_001745727.1 170682486 6143337 3826989..3827933 1 NC_010498.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3827933 nikB 6143337 nikB Escherichia coli SMS-3-5 nickel transporter permease NikB YP_001745727.1 3826989 D 439855 CDS YP_001745728.1 170683465 6146685 3827930..3828763 1 NC_010498.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3828763 nikC 6146685 nikC Escherichia coli SMS-3-5 nickel transporter permease NikC YP_001745728.1 3827930 D 439855 CDS YP_001745729.1 170683361 6142754 3828763..3829527 1 NC_010498.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3829527 nikD 6142754 nikD Escherichia coli SMS-3-5 nickel transporter ATP-binding protein NikD YP_001745729.1 3828763 D 439855 CDS YP_001745730.1 170680252 6142647 3829524..3830330 1 NC_010498.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3830330 nikE 6142647 nikE Escherichia coli SMS-3-5 nickel transporter ATP-binding protein NikE YP_001745730.1 3829524 D 439855 CDS YP_001745731.1 170679661 6144419 3830336..3830737 1 NC_010498.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3830737 nikR 6144419 nikR Escherichia coli SMS-3-5 nickel responsive regulator YP_001745731.1 3830336 D 439855 CDS YP_001745732.1 170681848 6143819 3830936..3831682 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 3831682 6143819 EcSMS35_3766 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001745732.1 3830936 D 439855 CDS YP_001745733.1 170681208 6146042 3831707..3832180 1 NC_010498.1 identified by match to protein family HMM PF00359; PEP-dependent sugar transporting PTS family, IIA component 3832180 6146042 EcSMS35_3767 Escherichia coli SMS-3-5 PEP-dependent sugar transporting PTS family, IIA component YP_001745733.1 3831707 D 439855 CDS YP_001745734.1 170682948 6145392 3832177..3832458 1 NC_010498.1 identified by similarity to SP:P37188; match to protein family HMM PF02302; PEP-dependent sugar transporting PTS family, IIB component 3832458 6145392 EcSMS35_3768 Escherichia coli SMS-3-5 PEP-dependent sugar transporting PTS family, IIB component YP_001745734.1 3832177 D 439855 CDS YP_001745735.1 170682820 6147163 3832532..3833890 1 NC_010498.1 identified by match to protein family HMM PF03611; PEP-dependent sugar transporting PTS family, IIC component 3833890 6147163 EcSMS35_3769 Escherichia coli SMS-3-5 PEP-dependent sugar transporting PTS family, IIC component YP_001745735.1 3832532 D 439855 CDS YP_001745736.1 170682100 6147031 3833883..3835391 1 NC_010498.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; carbohydrate kinase 3835391 6147031 EcSMS35_3770 Escherichia coli SMS-3-5 carbohydrate kinase YP_001745736.1 3833883 D 439855 CDS YP_001745737.1 170683793 6146298 3835381..3835650 1 NC_010498.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; HPr family phosphocarrier protein 3835650 6146298 EcSMS35_3771 Escherichia coli SMS-3-5 HPr family phosphocarrier protein YP_001745737.1 3835381 D 439855 CDS YP_001745738.1 170682827 6143086 3835682..3836542 1 NC_010498.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; putative fructose-1,6-bisphosphate aldolase 3836542 gatY 6143086 gatY Escherichia coli SMS-3-5 putative fructose-1,6-bisphosphate aldolase YP_001745738.1 3835682 D 439855 CDS YP_001745739.1 170682114 6147038 complement(3836592..3836924) 1 NC_010498.1 identified by match to protein family HMM PF05534; HicB family protein 3836924 6147038 EcSMS35_3773 Escherichia coli SMS-3-5 HicB family protein YP_001745739.1 3836592 R 439855 CDS YP_001745740.1 170683726 6146312 complement(3837295..3838419) 1 NC_010498.1 identified by match to protein family HMM PF01061; ABC transporter ATP-binding protein 3838419 6146312 EcSMS35_3774 Escherichia coli SMS-3-5 ABC transporter ATP-binding protein YP_001745740.1 3837295 R 439855 CDS YP_001745741.1 170680682 6143018 complement(3838419..3841154) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM PF01061; ABC transporter ATP binding protein 3841154 6143018 EcSMS35_3775 Escherichia coli SMS-3-5 ABC transporter ATP binding protein YP_001745741.1 3838419 R 439855 CDS YP_001745742.1 170680028 6144857 complement(3841151..3842218) 1 NC_010498.1 identified by match to protein family HMM PF00529; MFP family transporter 3842218 6144857 EcSMS35_3776 Escherichia coli SMS-3-5 MFP family transporter YP_001745742.1 3841151 R 439855 CDS YP_001745743.1 170681743 6144191 complement(3842281..3842394) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3842394 6144191 EcSMS35_3777 Escherichia coli SMS-3-5 hypothetical protein YP_001745743.1 3842281 R 439855 CDS YP_001745744.1 170681068 6145933 complement(3842584..3844206) 1 NC_010498.1 hypothetical protein 3844206 6145933 EcSMS35_3778 Escherichia coli SMS-3-5 hypothetical protein YP_001745744.1 3842584 R 439855 CDS YP_001745745.1 170682687 6145250 complement(3844468..3846120) 1 NC_010498.1 hypothetical protein 3846120 6145250 EcSMS35_3779 Escherichia coli SMS-3-5 hypothetical protein YP_001745745.1 3844468 R 439855 CDS YP_001745746.1 170682012 6146895 3846440..3847492 1 NC_010498.1 hypothetical protein 3847492 6146895 EcSMS35_3780 Escherichia coli SMS-3-5 hypothetical protein YP_001745746.1 3846440 D 439855 CDS YP_001745747.1 170683730 6146209 complement(3847807..3849009) 1 NC_010498.1 identified by match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR00275; pyridine nucleotide-disulfide oxidoreductase family protein 3849009 6146209 EcSMS35_3781 Escherichia coli SMS-3-5 pyridine nucleotide-disulfide oxidoreductase family protein YP_001745747.1 3847807 R 439855 CDS YP_001745748.1 170681103 6143022 3849241..3850740 1 NC_010498.1 identified by match to protein family HMM PF01384; low-affinity inorganic phosphate transporter 1 3850740 pitA 6143022 pitA Escherichia coli SMS-3-5 low-affinity inorganic phosphate transporter 1 YP_001745748.1 3849241 D 439855 CDS YP_001745749.1 170682188 6145285 complement(3850811..3851092) 1 NC_010498.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 3851092 uspB 6145285 uspB Escherichia coli SMS-3-5 universal stress protein UspB YP_001745749.1 3850811 R 439855 CDS YP_001745750.1 170682727 6146387 3851537..3851971 1 NC_010498.1 identified by match to protein family HMM PF00582; universal stress protein A 3851971 uspA 6146387 uspA Escherichia coli SMS-3-5 universal stress protein A YP_001745750.1 3851537 D 439855 CDS YP_001745751.1 170682598 6146935 3852287..3853756 1 NC_010498.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3853756 6146935 EcSMS35_3785 Escherichia coli SMS-3-5 inner membrane transporter YhiP YP_001745751.1 3852287 D 439855 CDS YP_001745752.1 170683366 6146803 complement(3853805..3854557) 1 NC_010498.1 predicted SAM-dependent methyltransferase; putative methyltransferase 3854557 6146803 EcSMS35_3786 Escherichia coli SMS-3-5 putative methyltransferase YP_001745752.1 3853805 R 439855 CDS YP_001745753.1 170684269 6142652 complement(3854565..3856607) 1 NC_010498.1 identified by match to protein family HMM PF01432; oligopeptidase A 3856607 prlC 6142652 prlC Escherichia coli SMS-3-5 oligopeptidase A YP_001745753.1 3854565 R 439855 CDS YP_001745754.1 170679705 6143571 3856810..3857652 1 NC_010498.1 identified by match to protein family HMM PF04378; DNA utilization protein YhiR 3857652 yhiR 6143571 yhiR Escherichia coli SMS-3-5 DNA utilization protein YhiR YP_001745754.1 3856810 D 439855 CDS YP_001745755.1 170679895 6143863 3857724..3859076 1 NC_010498.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3859076 gor 6143863 gor Escherichia coli SMS-3-5 glutathione reductase YP_001745755.1 3857724 D 439855 CDS YP_001745756.1 170680664 6144057 complement(3859127..3859246) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3859246 6144057 EcSMS35_3790 Escherichia coli SMS-3-5 hypothetical protein YP_001745756.1 3859127 R 439855 CDS YP_001745757.1 170681487 6144839 3859241..3859414 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3859414 6144839 EcSMS35_3791 Escherichia coli SMS-3-5 hypothetical protein YP_001745757.1 3859241 D 439855 CDS YP_001745758.1 170682355 6145672 complement(3859738..3859851) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3859851 6145672 EcSMS35_3792 Escherichia coli SMS-3-5 hypothetical protein YP_001745758.1 3859738 R 439855 CDS YP_001745759.1 170681943 6146554 3859954..3860307 1 NC_010498.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3860307 arsR 6146554 arsR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor ArsR YP_001745759.1 3859954 D 439855 CDS YP_001745760.1 170683643 6146139 3860362..3861651 1 NC_010498.1 identified by match to protein family HMM PF02040; match to protein family HMM PF03600; match to protein family HMM TIGR00935; arsenical pump membrane protein 3861651 arsB 6146139 arsB Escherichia coli SMS-3-5 arsenical pump membrane protein YP_001745760.1 3860362 D 439855 CDS YP_001745761.1 170683373 6142935 3861664..3862089 1 NC_010498.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 3862089 arsC 6142935 arsC Escherichia coli SMS-3-5 arsenate reductase YP_001745761.1 3861664 D 439855 CDS YP_001745762.1 170683896 6142659 complement(3862110..3862430) 1 NC_010498.1 identified by match to protein family HMM PF01022; ArsR family transcriptional regulator 3862430 6142659 EcSMS35_3796 Escherichia coli SMS-3-5 ArsR family transcriptional regulator YP_001745762.1 3862110 R 439855 CDS YP_001745763.1 170679968 6143192 3862537..3863538 1 NC_010498.1 identified by match to protein family HMM PF03773; putative permease 3863538 6143192 EcSMS35_3797 Escherichia coli SMS-3-5 putative permease YP_001745763.1 3862537 D 439855 CDS YP_001745764.1 170680481 6144130 3864118..3865341 1 NC_010498.1 hypothetical protein 3865341 6144130 EcSMS35_3798 Escherichia coli SMS-3-5 hypothetical protein YP_001745764.1 3864118 D 439855 CDS YP_001745765.1 170680229 6144650 3865431..3866153 1 NC_010498.1 identified by match to protein family HMM PF03843; match to protein family HMM TIGR00752; Slp family outer membrane lipoprotein 3866153 6144650 EcSMS35_3799 Escherichia coli SMS-3-5 Slp family outer membrane lipoprotein YP_001745765.1 3865431 D 439855 CDS YP_001745766.1 170681778 6144395 3866306..3866836 1 NC_010498.1 identified by match to protein family HMM PF00196; transcriptional regulator DctR 3866836 dctR 6144395 dctR Escherichia coli SMS-3-5 transcriptional regulator DctR YP_001745766.1 3866306 D 439855 CDS YP_001745767.1 170682449 6145970 complement(3866897..3867925) 1 NC_010498.1 identified by similarity to SP:Q56990; match to protein family HMM PF05171; hemin transport protein HmuS 3867925 hmuS 6145970 hmuS Escherichia coli SMS-3-5 hemin transport protein HmuS YP_001745767.1 3866897 R 439855 CDS YP_001745768.1 170681293 6146648 complement(3867974..3869956) 1 NC_010498.1 identified by similarity to GB:AAC27809.1; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01785; match to protein family HMM TIGR01786; outer membrane heme/hemoglobin receptor ChuA 3869956 chuA 6146648 chuA Escherichia coli SMS-3-5 outer membrane heme/hemoglobin receptor ChuA YP_001745768.1 3867974 R 439855 CDS YP_001745769.1 170681807 6145477 3870325..3870486 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3870486 6145477 EcSMS35_3803 Escherichia coli SMS-3-5 hypothetical protein YP_001745769.1 3870325 D 439855 CDS YP_001745770.1 170679948 6146000 3870640..3871554 1 NC_010498.1 identified by match to protein family HMM PF01497; periplasmic-binding protein 3871554 6146000 EcSMS35_3804 Escherichia coli SMS-3-5 periplasmic-binding protein YP_001745770.1 3870640 D 439855 CDS YP_001745771.1 170680480 6144110 3871574..3872911 1 NC_010498.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3872911 6144110 EcSMS35_3805 Escherichia coli SMS-3-5 coproporphyrinogen III oxidase YP_001745771.1 3871574 D 439855 CDS YP_001745772.1 170682738 6144649 3872924..3873418 1 NC_010498.1 identified by match to protein family HMM PF06228; hypothetical protein 3873418 6144649 EcSMS35_3806 Escherichia coli SMS-3-5 hypothetical protein YP_001745772.1 3872924 D 439855 CDS YP_001745773.1 170684148 6146946 3873418..3874041 1 NC_010498.1 identified by similarity to GB:CAG75906.1; hypothetical protein 3874041 6146946 EcSMS35_3807 Escherichia coli SMS-3-5 hypothetical protein YP_001745773.1 3873418 D 439855 CDS YP_001745774.1 170682306 6143448 3874090..3875082 1 NC_010498.1 identified by match to protein family HMM PF01032; iron chelate ABC transporter permease 3875082 6143448 EcSMS35_3808 Escherichia coli SMS-3-5 iron chelate ABC transporter permease YP_001745774.1 3874090 D 439855 CDS YP_001745775.1 170683108 6146505 3875049..3875849 1 NC_010498.1 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 3875849 hmuV 6146505 hmuV Escherichia coli SMS-3-5 hemin importer ATP-binding subunit YP_001745775.1 3875049 D 439855 CDS YP_001745776.1 170680597 6147327 complement(3875901..3876560) 1 NC_010498.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase 3876560 6147327 EcSMS35_3810 Escherichia coli SMS-3-5 putative Mg(2+) transport ATPase YP_001745776.1 3875901 R 439855 CDS YP_001745777.1 170680820 6144769 complement(3876612..3876950) 1 NC_010498.1 acid-resistance protein 3876950 hdeB 6144769 hdeB Escherichia coli SMS-3-5 acid-resistance protein YP_001745777.1 3876612 R 439855 CDS YP_001745778.1 170680601 6144996 complement(3877054..3877386) 1 NC_010498.1 inactive form; acid-resistance protein 3877386 6144996 EcSMS35_3812 Escherichia coli SMS-3-5 acid-resistance protein YP_001745778.1 3877054 R 439855 CDS YP_001745779.1 170681166 6144775 3877668..3878213 1 NC_010498.1 acid-resistance membrane protein 3878213 6144775 EcSMS35_3813 Escherichia coli SMS-3-5 acid-resistance membrane protein YP_001745779.1 3877668 D 439855 CDS YP_001745780.1 170684050 6145350 3879011..3879538 1 NC_010498.1 transcriptional regulator GadE 3879538 gadE 6145350 gadE Escherichia coli SMS-3-5 transcriptional regulator GadE YP_001745780.1 3879011 D 439855 CDS YP_001745781.1 170679753 6143349 complement(3879855..3879947) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3879947 6143349 EcSMS35_3815 Escherichia coli SMS-3-5 hypothetical protein YP_001745781.1 3879855 R 439855 CDS YP_001745782.1 170682056 6143911 3879877..3881034 1 NC_010498.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3881034 mdtE 6143911 mdtE Escherichia coli SMS-3-5 multidrug efflux system protein MdtE YP_001745782.1 3879877 D 439855 CDS YP_001745783.1 170682414 6146253 3881059..3884172 1 NC_010498.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; multidrug resistance protein MdtF 3884172 mdtF 6146253 mdtF Escherichia coli SMS-3-5 multidrug resistance protein MdtF YP_001745783.1 3881059 D 439855 CDS YP_001745784.1 170680629 6146613 complement(3884535..3885263) 1 NC_010498.1 identified by match to protein family HMM PF00165; transcriptional regulator GadW 3885263 gadW 6146613 gadW Escherichia coli SMS-3-5 transcriptional regulator GadW YP_001745784.1 3884535 R 439855 CDS YP_001745785.1 170681182 6144804 complement(3885632..3886456) 1 NC_010498.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3886456 gadX 6144804 gadX Escherichia coli SMS-3-5 DNA-binding transcriptional regulator GadX YP_001745785.1 3885632 R 439855 CDS YP_001745786.1 170679884 6145366 complement(3886816..3888216) 1 NC_010498.1 identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; glutamate decarboxylase GadB 3888216 gadB 6145366 gadB Escherichia coli SMS-3-5 glutamate decarboxylase GadB YP_001745786.1 3886816 R 439855 CDS YP_001745787.1 170680372 6144046 complement(3888427..3889824) 1 NC_010498.1 identified by match to protein family HMM PF03150; di-heme cytochrome c peroxidase family protein 3889824 6144046 EcSMS35_3821 Escherichia coli SMS-3-5 di-heme cytochrome c peroxidase family protein YP_001745787.1 3888427 R 439855 CDS YP_001745788.1 170684224 6144540 3890005..3890124 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3890124 6144540 EcSMS35_3822 Escherichia coli SMS-3-5 hypothetical protein YP_001745788.1 3890005 D 439855 CDS YP_001745789.1 170680301 6143525 3890229..3891878 1 NC_010498.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3891878 treF 6143525 treF Escherichia coli SMS-3-5 trehalase YP_001745789.1 3890229 D 439855 CDS YP_001745790.1 170682867 6144469 complement(3891929..3892531) 1 NC_010498.1 identified by match to protein family HMM PF00196; match to protein family HMM PF08281; LuxR family transcriptional regulator 3892531 6144469 EcSMS35_3824 Escherichia coli SMS-3-5 LuxR family transcriptional regulator YP_001745790.1 3891929 R 439855 CDS YP_001745791.1 170682485 6147080 3892979..3893950 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3893950 6147080 EcSMS35_3825 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001745791.1 3892979 D 439855 CDS YP_001745792.1 170681590 6146684 3893999..3895012 1 NC_010498.1 yhjD; identified by match to protein family HMM PF03631; match to protein family HMM TIGR00766; putative ribonuclease 3895012 6146684 EcSMS35_3826 Escherichia coli SMS-3-5 putative ribonuclease YP_001745792.1 3893999 D 439855 CDS YP_001745793.1 170680913 6145775 3895404..3896726 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; MFS transporter, metabolite:H+ symporter (MHS) family protein 3896726 6145775 EcSMS35_3827 Escherichia coli SMS-3-5 MFS transporter, metabolite:H+ symporter (MHS) family protein YP_001745793.1 3895404 D 439855 CDS YP_001745794.1 170680242 6145094 complement(3896905..3898965) 1 NC_010498.1 identified by match to protein family HMM PF05170; AsmA family protein 3898965 6145094 EcSMS35_3828 Escherichia coli SMS-3-5 AsmA family protein YP_001745794.1 3896905 R 439855 CDS YP_001745795.1 170679587 6144409 complement(3899035..3899649) 1 NC_010498.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 3899649 6144409 EcSMS35_3829 Escherichia coli SMS-3-5 EAL domain-containing protein YP_001745795.1 3899035 R 439855 CDS YP_001745796.1 170683180 6143744 complement(3899875..3899997) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3899997 6143744 EcSMS35_3830 Escherichia coli SMS-3-5 hypothetical protein YP_001745796.1 3899875 R 439855 CDS YP_001745797.1 170683860 6147400 3900034..3900963 1 NC_010498.1 identified by match to protein family HMM PF00294; 2-dehydro-3-deoxygluconokinase 3900963 kdgK 6147400 kdgK Escherichia coli SMS-3-5 2-dehydro-3-deoxygluconokinase YP_001745797.1 3900034 D 439855 CDS YP_001745798.1 170680567 6143155 3901058..3902263 1 NC_010498.1 identified by similarity to GB:CAK15512.1; hypothetical protein 3902263 6143155 EcSMS35_3832 Escherichia coli SMS-3-5 hypothetical protein YP_001745798.1 3901058 D 439855 CDS YP_001745799.1 170679846 6144737 3902250..3904292 1 NC_010498.1 identified by similarity to GB:AAY95391.1; hypothetical protein 3904292 6144737 EcSMS35_3834 Escherichia coli SMS-3-5 hypothetical protein YP_001745799.1 3902250 D 439855 CDS YP_001745800.1 170681097 6144008 complement(3904270..3904800) 1 NC_010498.1 putative lipoprotein 3904800 6144008 EcSMS35_3833 Escherichia coli SMS-3-5 putative lipoprotein YP_001745800.1 3904270 R 439855 CDS YP_001745801.1 170682195 6145279 complement(3904983..3906479) 1 NC_010498.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16 family peptidase 3906479 6145279 EcSMS35_3835 Escherichia coli SMS-3-5 M16 family peptidase YP_001745801.1 3904983 R 439855 CDS YP_001745802.1 170682606 6146394 complement(3906699..3907985) 1 NC_010498.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 3907985 dctA 6146394 dctA Escherichia coli SMS-3-5 C4-dicarboxylate transporter DctA YP_001745802.1 3906699 R 439855 CDS YP_001745803.1 170683117 6146811 3907989..3908087 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3908087 6146811 EcSMS35_3837 Escherichia coli SMS-3-5 hypothetical protein YP_001745803.1 3907989 D 439855 CDS YP_001745804.1 170684297 6147336 complement(3908168..3910117) 1 NC_010498.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase 3910117 6147336 EcSMS35_3838 Escherichia coli SMS-3-5 putative phosphodiesterase YP_001745804.1 3908168 R 439855 CDS YP_001745805.1 170680722 6143599 complement(3910238..3913711) 1 NC_010498.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 3913711 6143599 EcSMS35_3839 Escherichia coli SMS-3-5 cellulose synthase subunit BcsC YP_001745805.1 3910238 R 439855 CDS YP_001745806.1 170683128 6144897 complement(3913693..3914805) 1 NC_010498.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 3914805 bcsZ 6144897 bcsZ Escherichia coli SMS-3-5 endo-1,4-D-glucanase YP_001745806.1 3913693 R 439855 CDS YP_001745807.1 170681414 6147347 complement(3914806..3917115) 1 NC_010498.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 3917115 bcsB 6147347 bcsB Escherichia coli SMS-3-5 cellulose synthase regulator protein YP_001745807.1 3914806 R 439855 CDS YP_001745808.1 170679974 6145598 complement(3917156..3919774) 1 NC_010498.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 3919774 bcsA 6145598 bcsA Escherichia coli SMS-3-5 cellulose synthase catalytic subunit YP_001745808.1 3917156 R 439855 CDS YP_001745809.1 170683872 6144136 complement(3919771..3920523) 1 NC_010498.1 identified by match to protein family HMM PF06564; match to protein family HMM TIGR03371; cell division protein 3920523 6144136 EcSMS35_3843 Escherichia coli SMS-3-5 cell division protein YP_001745809.1 3919771 R 439855 CDS YP_001745810.1 170683325 6143167 complement(3920535..3920723) 1 NC_010498.1 hypothetical protein 3920723 6143167 EcSMS35_3844 Escherichia coli SMS-3-5 hypothetical protein YP_001745810.1 3920535 R 439855 CDS YP_001745811.1 170682494 6142610 3921007..3922566 1 NC_010498.1 identified by match to protein family HMM TIGR03369; hypothetical protein 3922566 6142610 EcSMS35_3845 Escherichia coli SMS-3-5 hypothetical protein YP_001745811.1 3921007 D 439855 CDS YP_001745812.1 170682024 6146693 3922563..3922754 1 NC_010498.1 cellulose biosynthesis protein BcsF 3922754 bcsF 6146693 bcsF Escherichia coli SMS-3-5 cellulose biosynthesis protein BcsF YP_001745812.1 3922563 D 439855 CDS YP_001745813.1 170681114 6146221 3922751..3924430 1 NC_010498.1 identified by match to protein family HMM TIGR03368; hypothetical protein 3924430 6146221 EcSMS35_3847 Escherichia coli SMS-3-5 hypothetical protein YP_001745813.1 3922751 D 439855 CDS YP_001745814.1 170682994 6145297 complement(3924517..3924684) 1 NC_010498.1 identified by similarity to RF:NP_458295.1; hypothetical protein 3924684 6145297 EcSMS35_3848 Escherichia coli SMS-3-5 hypothetical protein YP_001745814.1 3924517 R 439855 CDS YP_001745815.1 170680001 6147210 3924865..3924996 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3924996 6147210 EcSMS35_3849 Escherichia coli SMS-3-5 hypothetical protein YP_001745815.1 3924865 D 439855 CDS YP_001745816.1 170681661 6144164 complement(3925001..3925168) 1 NC_010498.1 hypothetical protein 3925168 6144164 EcSMS35_3850 Escherichia coli SMS-3-5 hypothetical protein YP_001745816.1 3925001 R 439855 CDS YP_001745817.1 170683374 6145847 3925293..3925469 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3925469 6145847 EcSMS35_3851 Escherichia coli SMS-3-5 hypothetical protein YP_001745817.1 3925293 D 439855 CDS YP_001745818.1 170681290 6142660 complement(3925485..3925652) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3925652 6142660 EcSMS35_3852 Escherichia coli SMS-3-5 hypothetical protein YP_001745818.1 3925485 R 439855 CDS YP_001745819.1 170680485 6145474 3925777..3925953 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3925953 6145474 EcSMS35_3853 Escherichia coli SMS-3-5 hypothetical protein YP_001745819.1 3925777 D 439855 CDS YP_001745820.1 170679996 6144654 complement(3925969..3926136) 1 NC_010498.1 hypothetical protein 3926136 6144654 EcSMS35_3854 Escherichia coli SMS-3-5 hypothetical protein YP_001745820.1 3925969 R 439855 CDS YP_001745821.1 170684051 6144158 3926316..3926447 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3926447 6144158 EcSMS35_3855 Escherichia coli SMS-3-5 hypothetical protein YP_001745821.1 3926316 D 439855 CDS YP_001745822.1 170680436 6143350 complement(3926452..3926619) 1 NC_010498.1 hypothetical protein 3926619 6143350 EcSMS35_3856 Escherichia coli SMS-3-5 hypothetical protein YP_001745822.1 3926452 R 439855 CDS YP_001745823.1 170683082 6144605 3926634..3926804 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3926804 6144605 EcSMS35_3857 Escherichia coli SMS-3-5 hypothetical protein YP_001745823.1 3926634 D 439855 CDS YP_001745824.1 170682329 6147299 3927035..3928306 1 NC_010498.1 identified by match to protein family HMM TIGR00814; serine transporter family protein 3928306 6147299 EcSMS35_3858 Escherichia coli SMS-3-5 serine transporter family protein YP_001745824.1 3927035 D 439855 CDS YP_001745825.1 170680787 6146528 complement(3928336..3929340) 1 NC_010498.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 3929340 dppF 6146528 dppF Escherichia coli SMS-3-5 dipeptide transporter ATP-binding subunit YP_001745825.1 3928336 R 439855 CDS YP_001745826.1 170682826 6144962 complement(3929337..3930320) 1 NC_010498.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 3930320 dppD 6144962 dppD Escherichia coli SMS-3-5 dipeptide transporter ATP-binding subunit YP_001745826.1 3929337 R 439855 CDS YP_001745827.1 170680093 6147037 complement(3930331..3931233) 1 NC_010498.1 identified by match to protein family HMM PF00528; dipeptide transporter 3931233 dppC 6147037 dppC Escherichia coli SMS-3-5 dipeptide transporter YP_001745827.1 3930331 R 439855 CDS YP_001745828.1 170681195 6144257 complement(3931243..3932262) 1 NC_010498.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 3932262 dppB 6144257 dppB Escherichia coli SMS-3-5 dipeptide transporter permease DppB YP_001745828.1 3931243 R 439855 CDS YP_001745829.1 170680118 6145379 3932280..3932423 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3932423 6145379 EcSMS35_3864 Escherichia coli SMS-3-5 hypothetical protein YP_001745829.1 3932280 D 439855 CDS YP_001745830.1 170679624 6144283 complement(3932413..3934020) 1 NC_010498.1 identified by match to protein family HMM PF00496; dipeptide ABC transporter periplasmic dipeptide-binding protein 3934020 dppA 6144283 dppA Escherichia coli SMS-3-5 dipeptide ABC transporter periplasmic dipeptide-binding protein YP_001745830.1 3932413 R 439855 CDS YP_001745831.1 170683297 6143781 complement(3934372..3934635) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3934635 6143781 EcSMS35_3865 Escherichia coli SMS-3-5 hypothetical protein YP_001745831.1 3934372 R 439855 CDS YP_001745832.1 170682619 6143697 complement(3934932..3936623) 1 NC_010498.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 3936623 6143697 EcSMS35_3867 Escherichia coli SMS-3-5 phosphoethanolamine transferase YP_001745832.1 3934932 R 439855 CDS YP_001745833.1 170682261 6146825 complement(3936947..3938155) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00890; major facilitator family transporter 3938155 6146825 EcSMS35_3868 Escherichia coli SMS-3-5 major facilitator family transporter YP_001745833.1 3936947 R 439855 CDS YP_001745834.1 170681569 6146460 complement(3938384..3939082) 1 NC_010498.1 hypothetical protein 3939082 6146460 EcSMS35_3869 Escherichia coli SMS-3-5 hypothetical protein YP_001745834.1 3938384 R 439855 CDS YP_001745835.1 170682694 6145754 3939240..3939803 1 NC_010498.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3939803 tag 6145754 tag Escherichia coli SMS-3-5 3-methyl-adenine DNA glycosylase I YP_001745835.1 3939240 D 439855 CDS YP_001745836.1 170681336 6146902 3939800..3940240 1 NC_010498.1 identified by match to protein family HMM PF00583; hypothetical protein 3940240 6146902 EcSMS35_3872 Escherichia coli SMS-3-5 hypothetical protein YP_001745836.1 3939800 D 439855 CDS YP_001745837.1 170681133 6145520 complement(3940209..3942542) 1 NC_010498.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; biotin sulfoxide reductase 3942542 bisC 6145520 bisC Escherichia coli SMS-3-5 biotin sulfoxide reductase YP_001745837.1 3940209 R 439855 CDS YP_001745838.1 170680831 6145316 3942695..3943354 1 NC_010498.1 identified by match to protein family HMM PF00691; match to protein family HMM PF05433; putative outer membrane lipoprotein 3943354 6145316 EcSMS35_3873 Escherichia coli SMS-3-5 putative outer membrane lipoprotein YP_001745838.1 3942695 D 439855 CDS YP_001745839.1 170680157 6145008 3943458..3944432 1 NC_010498.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826; 2-ketogluconate reductase 3944432 tkrA 6145008 tkrA Escherichia coli SMS-3-5 2-ketogluconate reductase YP_001745839.1 3943458 D 439855 CDS YP_001745840.1 170680625 6144323 complement(3944482..3945192) 1 NC_010498.1 putative lipoprotein 3945192 6144323 EcSMS35_3875 Escherichia coli SMS-3-5 putative lipoprotein YP_001745840.1 3944482 R 439855 CDS YP_001745841.1 170680103 6144800 3945626..3945916 1 NC_010498.1 putative transcriptional regulator 3945916 6144800 EcSMS35_3876 Escherichia coli SMS-3-5 putative transcriptional regulator YP_001745841.1 3945626 D 439855 CDS YP_001745842.1 170683736 6144267 3946197..3946409 1 NC_010498.1 identified by match to protein family HMM PF00313; major cold shock protein 3946409 6144267 EcSMS35_3877 Escherichia coli SMS-3-5 major cold shock protein YP_001745842.1 3946197 D 439855 CDS YP_001745843.1 170683209 6143028 complement(3946598..3946750) 1 NC_010498.1 identified by match to protein family HMM PF01848; small toxic polypeptide 3946750 hokA 6143028 hokA Escherichia coli SMS-3-5 small toxic polypeptide YP_001745843.1 3946598 R 439855 CDS YP_001745844.1 170682692 6147430 3946830..3947351 1 NC_010498.1 IS150 transposase orfA 3947351 6147430 EcSMS35_3879 Escherichia coli SMS-3-5 IS150 transposase orfA YP_001745844.1 3946830 D 439855 CDS YP_001745845.1 170683565 6146900 3947348..3948199 1 NC_010498.1 identified by match to protein family HMM PF00665; IS150 transposase orfB 3948199 6146900 EcSMS35_3880 Escherichia coli SMS-3-5 IS150 transposase orfB YP_001745845.1 3947348 D 439855 CDS YP_001745846.1 170682940 6142855 complement(3948477..3950546) 1 NC_010498.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 3950546 glyS 6142855 glyS Escherichia coli SMS-3-5 glycyl-tRNA synthetase subunit beta YP_001745846.1 3948477 R 439855 CDS YP_001745847.1 170683810 6147154 complement(3950556..3951467) 1 NC_010498.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 3951467 glyQ 6147154 glyQ Escherichia coli SMS-3-5 glycyl-tRNA synthetase subunit alpha YP_001745847.1 3950556 R 439855 CDS YP_001745848.1 170684097 6143104 complement(3951562..3951870) 1 NC_010498.1 hypothetical protein 3951870 6143104 EcSMS35_3883 Escherichia coli SMS-3-5 hypothetical protein YP_001745848.1 3951562 R 439855 CDS YP_001745849.1 170680005 6143397 3952045..3953040 1 NC_010498.1 acyltransferase family protein 3953040 6143397 EcSMS35_3884 Escherichia coli SMS-3-5 acyltransferase family protein YP_001745849.1 3952045 D 439855 CDS YP_001745850.1 170679941 6144168 complement(3953082..3953519) 1 NC_010498.1 identified by match to protein family HMM PF05360; hypothetical protein 3953519 6144168 EcSMS35_3885 Escherichia coli SMS-3-5 hypothetical protein YP_001745850.1 3953082 R 439855 CDS YP_001745851.1 170680413 6144103 complement(3953565..3953906) 1 NC_010498.1 identified by match to protein family HMM PF05360; hypothetical protein 3953906 6144103 EcSMS35_3886 Escherichia coli SMS-3-5 hypothetical protein YP_001745851.1 3953565 R 439855 CDS YP_001745852.1 170680828 6144582 complement(3954075..3955529) 1 NC_010498.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR01312; xylulokinase 3955529 xylB 6144582 xylB Escherichia coli SMS-3-5 xylulokinase YP_001745852.1 3954075 R 439855 CDS YP_001745853.1 170681343 6145005 complement(3955601..3956923) 1 NC_010498.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 3956923 xylA 6145005 xylA Escherichia coli SMS-3-5 xylose isomerase YP_001745853.1 3955601 R 439855 CDS YP_001745854.1 170682540 6145527 3957289..3958281 1 NC_010498.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3958281 xylF 6145527 xylF Escherichia coli SMS-3-5 D-xylose transporter subunit XylF YP_001745854.1 3957289 D 439855 CDS YP_001745855.1 170683069 6146741 3958359..3959900 1 NC_010498.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 3959900 xylG 6146741 xylG Escherichia coli SMS-3-5 xylose transporter ATP-binding subunit YP_001745855.1 3958359 D 439855 CDS YP_001745856.1 170683622 6147286 3959878..3961059 1 NC_010498.1 identified by match to protein family HMM PF02653; D-xylose ABC transporter permease 3961059 xylH 6147286 xylH Escherichia coli SMS-3-5 D-xylose ABC transporter permease YP_001745856.1 3959878 D 439855 CDS YP_001745857.1 170682140 6142912 3961137..3962315 1 NC_010498.1 identified by match to protein family HMM PF00165; xylose operon regulatory protein 3962315 xylR 6142912 xylR Escherichia coli SMS-3-5 xylose operon regulatory protein YP_001745857.1 3961137 D 439855 CDS YP_001745858.1 170683680 6146339 complement(3962423..3963247) 1 NC_010498.1 identified by match to protein family HMM PF01832; hypothetical protein 3963247 bax 6146339 bax Escherichia coli SMS-3-5 hypothetical protein YP_001745858.1 3962423 R 439855 CDS YP_001745859.1 170684113 6142972 3963567..3965597 1 NC_010498.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase precursor 3965597 malS 6142972 malS Escherichia coli SMS-3-5 periplasmic alpha-amylase precursor YP_001745859.1 3963567 D 439855 CDS YP_001745860.1 170683665 6143413 3965775..3967028 1 NC_010498.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3967028 avtA 6143413 avtA Escherichia coli SMS-3-5 valine--pyruvate transaminase YP_001745860.1 3965775 D 439855 CDS YP_001745861.1 170683893 6142957 complement(3967180..3967653) 1 NC_010498.1 identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein 3967653 6142957 EcSMS35_3896 Escherichia coli SMS-3-5 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein YP_001745861.1 3967180 R 439855 CDS YP_001745862.1 170680133 6143188 complement(3967755..3968603) 1 NC_010498.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator 3968603 6143188 EcSMS35_3897 Escherichia coli SMS-3-5 IclR family transcriptional regulator YP_001745862.1 3967755 R 439855 CDS YP_001745863.1 170680670 6144299 3968804..3969802 1 NC_010498.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3969802 dlgD 6144299 dlgD Escherichia coli SMS-3-5 2,3-diketo-L-gulonate reductase YP_001745863.1 3968804 D 439855 CDS YP_001745864.1 170681727 6144845 3969814..3970281 1 NC_010498.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 3970281 6144845 EcSMS35_3899 Escherichia coli SMS-3-5 hypothetical protein YP_001745864.1 3969814 D 439855 CDS YP_001745865.1 170682406 6145915 3970399..3970872 1 NC_010498.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3970872 6145915 EcSMS35_3900 Escherichia coli SMS-3-5 2,3-diketo-L-gulonate TRAP transporter small permease YiaM YP_001745865.1 3970399 D 439855 CDS YP_001745866.1 170682198 6146605 3970875..3972152 1 NC_010498.1 identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter, DctM subunit 3972152 6146605 EcSMS35_3901 Escherichia coli SMS-3-5 TRAP transporter, DctM subunit YP_001745866.1 3970875 D 439855 CDS YP_001745867.1 170679692 6146397 3972165..3973151 1 NC_010498.1 identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein 3973151 6146397 EcSMS35_3902 Escherichia coli SMS-3-5 TRAP transporter solute receptor DctP family protein YP_001745867.1 3972165 D 439855 CDS YP_001745868.1 170679902 6143850 3973155..3974651 1 NC_010498.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; cryptic L-xylulose kinase 3974651 lyx 6143850 lyx Escherichia coli SMS-3-5 cryptic L-xylulose kinase YP_001745868.1 3973155 D 439855 CDS YP_001745869.1 170684279 6144064 3974648..3975310 1 NC_010498.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 3975310 sgbH 6144064 sgbH Escherichia coli SMS-3-5 3-keto-L-gulonate-6-phosphate decarboxylase YP_001745869.1 3974648 D 439855 CDS YP_001745870.1 170682927 6143581 3975303..3976163 1 NC_010498.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 3976163 6143581 EcSMS35_3905 Escherichia coli SMS-3-5 putative L-xylulose 5-phosphate 3-epimerase YP_001745870.1 3975303 D 439855 CDS YP_001745871.1 170682264 6147141 3976157..3976852 1 NC_010498.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 3976852 sgbE 6147141 sgbE Escherichia coli SMS-3-5 L-ribulose-5-phosphate 4-epimerase YP_001745871.1 3976157 D 439855 CDS YP_001745872.1 170681568 6146463 complement(3976884..3977699) 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 3977699 6146463 EcSMS35_3907 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001745872.1 3976884 R 439855 CDS YP_001745873.1 170680906 6145753 3977925..3979325 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792; sugar glycoside-pentoside-hexuronide family protein 3979325 6145753 EcSMS35_3908 Escherichia coli SMS-3-5 sugar glycoside-pentoside-hexuronide family protein YP_001745873.1 3977925 D 439855 CDS YP_001745874.1 170681898 6145085 3979336..3981306 1 NC_010498.1 identified by similarity to GB:CAD07947.1; match to protein family HMM PF07944; hypothetical protein 3981306 6145085 EcSMS35_3909 Escherichia coli SMS-3-5 hypothetical protein YP_001745874.1 3979336 D 439855 CDS YP_001745875.1 170680250 6146093 complement(3981436..3982176) 1 NC_010498.1 identified by match to protein family HMM PF06629; MltA-interacting protein MipA 3982176 6146093 EcSMS35_3910 Escherichia coli SMS-3-5 MltA-interacting protein MipA YP_001745875.1 3981436 R 439855 CDS YP_001745876.1 170682011 6144417 3982300..3983274 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3983274 6144417 EcSMS35_3912 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001745876.1 3982300 D 439855 CDS YP_001745877.1 170680467 6146208 complement(3983271..3984407) 1 NC_010498.1 identified by match to protein family HMM PF00529; membrane fusion protein family protein 3984407 6146208 EcSMS35_3911 Escherichia coli SMS-3-5 membrane fusion protein family protein YP_001745877.1 3983271 R 439855 CDS YP_001745878.1 170683463 6144636 complement(3984413..3984736) 1 NC_010498.1 hypothetical protein 3984736 6144636 EcSMS35_3913 Escherichia coli SMS-3-5 hypothetical protein YP_001745878.1 3984413 R 439855 CDS YP_001745879.1 170684317 6142752 3984918..3985061 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 3985061 6142752 EcSMS35_3914 Escherichia coli SMS-3-5 hypothetical protein YP_001745879.1 3984918 D 439855 CDS YP_001745880.1 170679828 6143619 complement(3985280..3986818) 1 NC_010498.1 identified by match to protein family HMM PF00171; aldehyde dehydrogenase B 3986818 aldB 6143619 aldB Escherichia coli SMS-3-5 aldehyde dehydrogenase B YP_001745880.1 3985280 R 439855 CDS YP_001745881.1 170680544 6143990 complement(3986926..3988221) 1 NC_010498.1 identified by match to protein family HMM PF02661; Fic family protein 3988221 6143990 EcSMS35_3916 Escherichia coli SMS-3-5 Fic family protein YP_001745881.1 3986926 R 439855 CDS YP_001745882.1 170680821 6144714 complement(3988351..3989502) 1 NC_010498.1 identified by match to protein family HMM PF00465; putative alcohol dehydrogenase 3989502 adhB 6144714 adhB Escherichia coli SMS-3-5 putative alcohol dehydrogenase YP_001745882.1 3988351 R 439855 CDS YP_001745883.1 170681383 6144997 complement(3989693..3991537) 1 NC_010498.1 identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM PF09106; match to protein family HMM PF09107; match to protein family HMM TIGR00475; selenocysteinyl-tRNA-specific translation factor 3991537 selB 6144997 selB Escherichia coli SMS-3-5 selenocysteinyl-tRNA-specific translation factor YP_001745883.1 3989693 R 439855 CDS YP_001745884.1 170680855 6145567 complement(3991534..3992925) 1 NC_010498.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 3992925 selA 6145567 selA Escherichia coli SMS-3-5 selenocysteine synthase YP_001745884.1 3991534 R 439855 CDS YP_001745885.1 170681377 6145032 complement(3993023..3993631) 1 NC_010498.1 yibF; identified by match to protein family HMM PF00043; match to protein family HMM PF02798; putative glutathione S-transferase 3993631 6145032 EcSMS35_3920 Escherichia coli SMS-3-5 putative glutathione S-transferase YP_001745885.1 3993023 R 439855 CDS YP_001745886.1 170682879 6145561 complement(3993788..3997597) 1 NC_010498.1 identified by match to protein family HMM PF02395; match to protein family HMM PF03797; match to protein family HMM TIGR01414; outer membrane autotransporter 3997597 6145561 EcSMS35_3921 Escherichia coli SMS-3-5 outer membrane autotransporter YP_001745886.1 3993788 R 439855 CDS YP_001745887.1 170681457 6147092 complement(3997769..3998287) 1 NC_010498.1 identified by similarity to SP:P20862; putative fimbrial protein FanH 3998287 6147092 EcSMS35_3922 Escherichia coli SMS-3-5 putative fimbrial protein FanH YP_001745887.1 3997769 R 439855 CDS YP_001745888.1 170684225 6145642 complement(3998280..3998702) 1 NC_010498.1 putative fimbrial protein FanG 3998702 6145642 EcSMS35_3923 Escherichia coli SMS-3-5 putative fimbrial protein FanG YP_001745888.1 3998280 R 439855 CDS YP_001745889.1 170682510 6143526 complement(3998815..3999786) 1 NC_010498.1 putative fimbrial protein FanF 3999786 6143526 EcSMS35_3924 Escherichia coli SMS-3-5 putative fimbrial protein FanF YP_001745889.1 3998815 R 439855 CDS YP_001745890.1 170679645 6146710 complement(3999816..4000496) 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putative fimbrial assembly chaperone FanE 4000496 6146710 EcSMS35_3925 Escherichia coli SMS-3-5 putative fimbrial assembly chaperone FanE YP_001745890.1 3999816 R 439855 CDS YP_001745891.1 170681449 6143802 complement(4000504..4002861) 1 NC_010498.1 identified by match to protein family HMM PF00577; putative fimbrial usher protein FanD 4002861 6143802 EcSMS35_3926 Escherichia coli SMS-3-5 putative fimbrial usher protein FanD YP_001745891.1 4000504 R 439855 CDS YP_001745892.1 170680375 6145634 complement(4002933..4003460) 1 NC_010498.1 identified by match to protein family HMM PF00419; putative fimbrial protein FanC 4003460 6145634 EcSMS35_3927 Escherichia coli SMS-3-5 putative fimbrial protein FanC YP_001745892.1 4002933 R 439855 CDS YP_001745893.1 170683044 6144543 4004205..4004711 1 NC_010498.1 identified by match to protein family HMM PF08281; sigma-70 domain-containing protein 4004711 6144543 EcSMS35_3928 Escherichia coli SMS-3-5 sigma-70 domain-containing protein YP_001745893.1 4004205 D 439855 CDS YP_001745894.1 170682515 6147260 4004902..4005732 1 NC_010498.1 identified by match to protein family HMM PF00165; putative fimbrial operon positive regulatory protein FanR 4005732 6147260 EcSMS35_3929 Escherichia coli SMS-3-5 putative fimbrial operon positive regulatory protein FanR YP_001745894.1 4004902 D 439855 CDS YP_001745895.1 170682468 6146715 complement(4005888..4007024) 1 NC_010498.1 identified by match to protein family HMM PF00529; auxiliary membrane fusion protein family transporter 4007024 6146715 EcSMS35_3930 Escherichia coli SMS-3-5 auxiliary membrane fusion protein family transporter YP_001745895.1 4005888 R 439855 CDS YP_001745896.1 170684003 6146667 complement(4007027..4007491) 1 NC_010498.1 hypothetical protein 4007491 6146667 EcSMS35_3931 Escherichia coli SMS-3-5 hypothetical protein YP_001745896.1 4007027 R 439855 CDS YP_001745897.1 170683486 6143302 4007925..4009838 1 NC_010498.1 identified by match to protein family HMM PF00359; match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; PTS system, mannitol-specific IIABC component 4009838 mtlA 6143302 mtlA Escherichia coli SMS-3-5 PTS system, mannitol-specific IIABC component YP_001745897.1 4007925 D 439855 CDS YP_001745898.1 170681271 6142775 4009933..4011081 1 NC_010498.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 4011081 mtlD 6142775 mtlD Escherichia coli SMS-3-5 mannitol-1-phosphate 5-dehydrogenase YP_001745898.1 4009933 D 439855 CDS YP_001745899.1 170680458 6145455 4011081..4011668 1 NC_010498.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4011668 mtlR 6145455 mtlR Escherichia coli SMS-3-5 mannitol repressor protein YP_001745899.1 4011081 D 439855 CDS YP_001745900.1 170679949 6144627 complement(4011679..4011888) 1 NC_010498.1 hypothetical protein 4011888 6144627 EcSMS35_3935 Escherichia coli SMS-3-5 hypothetical protein YP_001745900.1 4011679 R 439855 CDS YP_001745901.1 170683878 6144111 4012172..4012534 1 NC_010498.1 hypothetical protein 4012534 6144111 EcSMS35_3936 Escherichia coli SMS-3-5 hypothetical protein YP_001745901.1 4012172 D 439855 CDS YP_001745902.1 170683349 6143173 complement(4012790..4013017) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4013017 6143173 EcSMS35_3937 Escherichia coli SMS-3-5 hypothetical protein YP_001745902.1 4012790 R 439855 CDS YP_001745903.1 170682531 6142635 4013092..4013775 1 NC_010498.1 putative lipoprotein 4013775 6142635 EcSMS35_3938 Escherichia coli SMS-3-5 putative lipoprotein YP_001745903.1 4013092 D 439855 CDS YP_001745904.1 170684255 6146732 4013819..4018468 1 NC_010498.1 identified by match to protein family HMM PF03895; match to protein family HMM PF05658; match to protein family HMM PF05662; hemagluttinin family protein 4018468 6146732 EcSMS35_3939 Escherichia coli SMS-3-5 hemagluttinin family protein YP_001745904.1 4013819 D 439855 CDS YP_001745905.1 170681119 6143557 4018766..4020421 1 NC_010498.1 identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795; L-lactate permease 4020421 lldP 6143557 lldP Escherichia coli SMS-3-5 L-lactate permease YP_001745905.1 4018766 D 439855 CDS YP_001745906.1 170682830 6145302 4020421..4021197 1 NC_010498.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4021197 6145302 EcSMS35_3941 Escherichia coli SMS-3-5 DNA-binding transcriptional repressor LldR YP_001745906.1 4020421 D 439855 CDS YP_001745907.1 170679931 6147041 4021194..4022384 1 NC_010498.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4022384 lldD 6147041 lldD Escherichia coli SMS-3-5 L-lactate dehydrogenase YP_001745907.1 4021194 D 439855 CDS YP_001745908.1 170680159 6144093 4022432..4022905 1 NC_010498.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 4022905 6144093 EcSMS35_3943 Escherichia coli SMS-3-5 putative tRNA/rRNA methyltransferase YibK YP_001745908.1 4022432 D 439855 CDS YP_001745909.1 170682618 6144325 complement(4022958..4023779) 1 NC_010498.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4023779 cysE 6144325 cysE Escherichia coli SMS-3-5 serine acetyltransferase YP_001745909.1 4022958 R 439855 CDS YP_001745910.1 170683136 6146824 complement(4023859..4024878) 1 NC_010498.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4024878 gpsA 6146824 gpsA Escherichia coli SMS-3-5 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001745910.1 4023859 R 439855 CDS YP_001745911.1 170681903 6147355 complement(4024878..4025345) 1 NC_010498.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4025345 secB 6147355 secB Escherichia coli SMS-3-5 preprotein translocase subunit SecB YP_001745911.1 4024878 R 439855 CDS YP_001745912.1 170682334 6146098 complement(4025408..4025659) 1 NC_010498.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR02181; glutaredoxin 3 4025659 grxC 6146098 grxC Escherichia coli SMS-3-5 glutaredoxin 3 YP_001745912.1 4025408 R 439855 CDS YP_001745913.1 170679980 6146533 complement(4025801..4026232) 1 NC_010498.1 identified by match to protein family HMM PF00581; rhodanese domain-containing protein 4026232 6146533 EcSMS35_3948 Escherichia coli SMS-3-5 rhodanese domain-containing protein YP_001745913.1 4025801 R 439855 CDS YP_001745914.1 170681198 6144142 4026477..4028021 1 NC_010498.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4028021 gpmI 6144142 gpmI Escherichia coli SMS-3-5 phosphoglyceromutase YP_001745914.1 4026477 D 439855 CDS YP_001745915.1 170684238 6145382 4028055..4029314 1 NC_010498.1 identified by match to protein family HMM PF01551; hypothetical protein 4029314 6145382 EcSMS35_3950 Escherichia coli SMS-3-5 hypothetical protein YP_001745915.1 4028055 D 439855 CDS YP_001745916.1 170683133 6143539 4029318..4030277 1 NC_010498.1 identified by match to protein family HMM PF04748; polysaccharide deacetylase family protein 4030277 6143539 EcSMS35_3952 Escherichia coli SMS-3-5 polysaccharide deacetylase family protein YP_001745916.1 4029318 D 439855 CDS YP_001745917.1 170679583 6147352 complement(4030264..4031298) 1 NC_010498.1 identified by match to protein family HMM PF00535; putative glycosyl transferase 4031298 6147352 EcSMS35_3951 Escherichia coli SMS-3-5 putative glycosyl transferase YP_001745917.1 4030264 R 439855 CDS YP_001745918.1 170683839 6143740 complement(4031537..4032562) 1 NC_010498.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4032562 tdh 6143740 tdh Escherichia coli SMS-3-5 L-threonine 3-dehydrogenase YP_001745918.1 4031537 R 439855 CDS YP_001745919.1 170682117 6143133 complement(4032572..4033768) 1 NC_010498.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 4033768 kbl 6143133 kbl Escherichia coli SMS-3-5 2-amino-3-ketobutyrate coenzyme A ligase YP_001745919.1 4032572 R 439855 CDS YP_001745920.1 170682822 6146315 complement(4033814..4033963) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4033963 6146315 EcSMS35_3955 Escherichia coli SMS-3-5 hypothetical protein YP_001745920.1 4033814 R 439855 CDS YP_001745921.1 170683119 6147033 4033982..4034914 1 NC_010498.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 4034914 rfaD 6147033 rfaD Escherichia coli SMS-3-5 ADP-L-glycero-D-mannoheptose-6-epimerase YP_001745921.1 4033982 D 439855 CDS YP_001745922.1 170683841 6147338 4034924..4035970 1 NC_010498.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4035970 rfaF 6147338 rfaF Escherichia coli SMS-3-5 ADP-heptose:LPS heptosyltransferase II YP_001745922.1 4034924 D 439855 CDS YP_001745923.1 170682077 6143135 4035974..4036945 1 NC_010498.1 identified by match to protein family HMM PF01075; match to protein family HMM TIGR02193; ADP-heptose:LPS heptosyl transferase I 4036945 rfaC 6143135 rfaC Escherichia coli SMS-3-5 ADP-heptose:LPS heptosyl transferase I YP_001745923.1 4035974 D 439855 CDS YP_001745924.1 170682768 6146274 complement(4037015..4038268) 1 NC_010498.1 identified by match to protein family HMM PF04932; O-antigen polymerase 4038268 6146274 EcSMS35_3959 Escherichia coli SMS-3-5 O-antigen polymerase YP_001745924.1 4037015 R 439855 CDS YP_001745925.1 170681613 6146977 complement(4038314..4039297) 1 NC_010498.1 identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein 4039297 6146977 EcSMS35_3960 Escherichia coli SMS-3-5 glycosyl transferase, group 2 family protein YP_001745925.1 4038314 R 439855 CDS YP_001745926.1 170682179 6145798 complement(4039379..4040407) 1 NC_010498.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,2-galactosyltransferase 4040407 waaW 6145798 waaW Escherichia coli SMS-3-5 lipopolysaccharide 1,2-galactosyltransferase YP_001745926.1 4039379 R 439855 CDS YP_001745927.1 170680583 6146378 complement(4040433..4041125) 1 NC_010498.1 identified by match to protein family HMM PF06176; lipopolysaccharide core biosynthesis protein 4041125 rfaY 6146378 rfaY Escherichia coli SMS-3-5 lipopolysaccharide core biosynthesis protein YP_001745927.1 4040433 R 439855 CDS YP_001745928.1 170679827 6144753 complement(4041135..4042130) 1 NC_010498.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,2-glucosyltransferase 4042130 rfaJ2 6144753 rfaJ2 Escherichia coli SMS-3-5 lipopolysaccharide 1,2-glucosyltransferase YP_001745928.1 4041135 R 439855 CDS YP_001745929.1 170681283 6143989 complement(4042147..4043163) 1 NC_010498.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,3-galactosyltransferase 4043163 rfaI 6143989 rfaI Escherichia coli SMS-3-5 lipopolysaccharide 1,3-galactosyltransferase YP_001745929.1 4042147 R 439855 CDS YP_001745930.1 170681792 6145467 complement(4043179..4043976) 1 NC_010498.1 identified by match to protein family HMM PF06293; lipopolysaccharide core biosynthesis protein RfaP 4043976 rfaP 6145467 rfaP Escherichia coli SMS-3-5 lipopolysaccharide core biosynthesis protein RfaP YP_001745930.1 4043179 R 439855 CDS YP_001745931.1 170682059 6145985 complement(4043969..4045093) 1 NC_010498.1 identified by match to protein family HMM PF00534; lipopolysaccharide core biosynthesis protein RfaG 4045093 rfaG 6145985 rfaG Escherichia coli SMS-3-5 lipopolysaccharide core biosynthesis protein RfaG YP_001745931.1 4043969 R 439855 CDS YP_001745932.1 170682581 6146256 complement(4045090..4046148) 1 NC_010498.1 identified by match to protein family HMM PF01075; match to protein family HMM TIGR02201; lipopolysaccharide core biosynthesis protein 4046148 rfaQ 6146256 rfaQ Escherichia coli SMS-3-5 lipopolysaccharide core biosynthesis protein YP_001745932.1 4045090 R 439855 CDS YP_001745933.1 170682133 6146786 4046561..4047838 1 NC_010498.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4047838 waaA 6146786 waaA Escherichia coli SMS-3-5 3-deoxy-D-manno-octulosonic-acid transferase YP_001745933.1 4046561 D 439855 CDS YP_001745934.1 170682523 6146332 4047846..4048325 1 NC_010498.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4048325 coaD 6146332 coaD Escherichia coli SMS-3-5 phosphopantetheine adenylyltransferase YP_001745934.1 4047846 D 439855 CDS YP_001745935.1 170684053 6146724 complement(4048364..4049173) 1 NC_010498.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4049173 mutM 6146724 mutM Escherichia coli SMS-3-5 formamidopyrimidine-DNA glycosylase YP_001745935.1 4048364 R 439855 CDS YP_001745936.1 170683818 6143352 complement(4049271..4049438) 1 NC_010498.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4049438 rpmG 6143352 rpmG Escherichia coli SMS-3-5 50S ribosomal protein L33 YP_001745936.1 4049271 R 439855 CDS YP_001745937.1 170680615 6143112 complement(4049459..4049695) 1 NC_010498.1 required for 70S ribosome assembly; 50S ribosomal protein L28 4049695 rpmB 6143112 rpmB Escherichia coli SMS-3-5 50S ribosomal protein L28 YP_001745937.1 4049459 R 439855 CDS YP_001745938.1 170682096 6144789 complement(4049912..4050580) 1 NC_010498.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4050580 radC 6144789 radC Escherichia coli SMS-3-5 DNA repair protein RadC YP_001745938.1 4049912 R 439855 CDS YP_001745939.1 170682495 6146294 4050752..4051972 1 NC_010498.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4051972 coaBC 6146294 coaBC Escherichia coli SMS-3-5 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_001745939.1 4050752 D 439855 CDS YP_001745940.1 170683040 6146695 4051950..4052408 1 NC_010498.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4052408 dut 6146695 dut Escherichia coli SMS-3-5 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001745940.1 4051950 D 439855 CDS YP_001745941.1 170684116 6147256 4052515..4053111 1 NC_010498.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4053111 slmA 6147256 slmA Escherichia coli SMS-3-5 nucleoid occlusion protein YP_001745941.1 4052515 D 439855 CDS YP_001745942.1 170679906 6143416 complement(4053148..4053789) 1 NC_010498.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4053789 pyrE 6143416 pyrE Escherichia coli SMS-3-5 orotate phosphoribosyltransferase YP_001745942.1 4053148 R 439855 CDS YP_001745943.1 170680501 6144068 complement(4053855..4054571) 1 NC_010498.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4054571 rph 6144068 rph Escherichia coli SMS-3-5 ribonuclease PH YP_001745943.1 4053855 R 439855 CDS YP_001745944.1 170680911 6144670 4054698..4055561 1 NC_010498.1 yicC; identified by match to protein family HMM PF03755; match to protein family HMM PF08340; match to protein family HMM TIGR00255; hypothetical protein 4055561 6144670 EcSMS35_3979 Escherichia coli SMS-3-5 hypothetical protein YP_001745944.1 4054698 D 439855 CDS YP_001745945.1 170680335 6145091 4055783..4056607 1 NC_010498.1 identified by similarity to SP:P23840; DNA-damage-inducible protein D 4056607 dinD 6145091 dinD Escherichia coli SMS-3-5 DNA-damage-inducible protein D YP_001745945.1 4055783 D 439855 CDS YP_001745946.1 170684015 6144503 4056898..4057515 1 NC_010498.1 identified by match to protein family HMM PF03458; hypothetical protein 4057515 6144503 EcSMS35_3982 Escherichia coli SMS-3-5 hypothetical protein YP_001745946.1 4056898 D 439855 CDS YP_001745947.1 170681126 6143314 complement(4057512..4059194) 1 NC_010498.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4059194 ligB 6143314 ligB Escherichia coli SMS-3-5 NAD-dependent DNA ligase LigB YP_001745947.1 4057512 R 439855 CDS YP_001745948.1 170683513 6145309 4059452..4060075 1 NC_010498.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4060075 gmk 6145309 gmk Escherichia coli SMS-3-5 guanylate kinase YP_001745948.1 4059452 D 439855 CDS YP_001745949.1 170681716 6142803 4060130..4060405 1 NC_010498.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4060405 rpoZ 6142803 rpoZ Escherichia coli SMS-3-5 DNA-directed RNA polymerase subunit omega YP_001745949.1 4060130 D 439855 CDS YP_001745950.1 170679973 6145904 4060424..4062532 1 NC_010498.1 identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4062532 spoT 6145904 spoT Escherichia coli SMS-3-5 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_001745950.1 4060424 D 439855 CDS YP_001745951.1 170681825 6144135 4062539..4063228 1 NC_010498.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4063228 trmH 6144135 trmH Escherichia coli SMS-3-5 tRNA guanosine-2'-O-methyltransferase YP_001745951.1 4062539 D 439855 CDS YP_001745952.1 170681314 6146018 4063234..4065315 1 NC_010498.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4065315 recG 6146018 recG Escherichia coli SMS-3-5 ATP-dependent DNA helicase RecG YP_001745952.1 4063234 D 439855 CDS YP_001745953.1 170682521 6145498 complement(4065349..4066554) 1 NC_010498.1 identified by match to protein family HMM PF03616; match to protein family HMM TIGR00210; sodium/glutamate symporter 4066554 gltS 6145498 gltS Escherichia coli SMS-3-5 sodium/glutamate symporter YP_001745953.1 4065349 R 439855 CDS YP_001745954.1 170682109 6146722 4066834..4068225 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; xanthine permease 4068225 yicE 6146722 yicE Escherichia coli SMS-3-5 xanthine permease YP_001745954.1 4066834 D 439855 CDS YP_001745955.1 170683972 6146307 4068346..4070055 1 NC_010498.1 identified by match to protein family HMM PF05170; AsmA family protein 4070055 6146307 EcSMS35_3990 Escherichia coli SMS-3-5 AsmA family protein YP_001745955.1 4068346 D 439855 CDS YP_001745956.1 170680492 6143269 complement(4070099..4070779) 1 NC_010498.1 identified by similarity to GB:CAH23042.1; match to protein family HMM PF07385; hypothetical protein 4070779 6143269 EcSMS35_3991 Escherichia coli SMS-3-5 hypothetical protein YP_001745956.1 4070099 R 439855 CDS YP_001745957.1 170680800 6144661 complement(4070760..4071692) 1 NC_010498.1 identified by match to protein family HMM PF00480; ROK family protein 4071692 6144661 EcSMS35_3992 Escherichia coli SMS-3-5 ROK family protein YP_001745957.1 4070760 R 439855 CDS YP_001745958.1 170682060 6144976 complement(4071740..4072600) 1 NC_010498.1 identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; hypothetical protein 4072600 6144976 EcSMS35_3993 Escherichia coli SMS-3-5 hypothetical protein YP_001745958.1 4071740 R 439855 CDS YP_001745959.1 170683929 6146257 complement(4072681..4073532) 1 NC_010498.1 identified by match to protein family HMM PF01116; fructose-bisphosphate aldolase, class II 4073532 6146257 EcSMS35_3994 Escherichia coli SMS-3-5 fructose-bisphosphate aldolase, class II YP_001745959.1 4072681 R 439855 CDS YP_001745960.1 170683316 6143295 complement(4074992..4075462) 1 NC_010498.1 identified by match to protein family HMM PF00359; match to protein family HMM TIGR00848; PTS system, fructose family, IIA component 4075462 6143295 EcSMS35_3996 Escherichia coli SMS-3-5 PTS system, fructose family, IIA component YP_001745960.1 4074992 R 439855 CDS YP_001745961.1 170680552 6142601 complement(4075489..4077042) 1 NC_010498.1 identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; putative PTS regulatory protein 4077042 6142601 EcSMS35_3997 Escherichia coli SMS-3-5 putative PTS regulatory protein YP_001745961.1 4075489 R 439855 CDS YP_001745962.1 170679913 6144722 4077076..4077189 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4077189 6144722 EcSMS35_3998 Escherichia coli SMS-3-5 hypothetical protein YP_001745962.1 4077076 D 439855 CDS YP_001745963.1 170680791 6144075 complement(4077337..4079655) 1 NC_010498.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI 4079655 yicI 6144075 yicI Escherichia coli SMS-3-5 alpha-xylosidase YicI YP_001745963.1 4077337 R 439855 CDS YP_001745964.1 170681221 6144966 complement(4079665..4081047) 1 NC_010498.1 may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter 4081047 6144966 EcSMS35_4000 Escherichia coli SMS-3-5 putative transporter YP_001745964.1 4079665 R 439855 CDS YP_001745965.1 170682095 6143699 4081597..4082760 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 4082760 6143699 EcSMS35_4002 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001745965.1 4081597 D 439855 CDS YP_001745966.1 170679594 6146293 4082773..4085493 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4085493 6146293 EcSMS35_4003 Escherichia coli SMS-3-5 hypothetical protein YP_001745966.1 4082773 D 439855 CDS YP_001745967.1 170680900 6143751 complement(4085695..4086267) 1 NC_010498.1 identified by match to protein family HMM PF07455; phage polarity suppression protein 4086267 6143751 EcSMS35_4004 Escherichia coli SMS-3-5 phage polarity suppression protein YP_001745967.1 4085695 R 439855 CDS YP_001745968.1 170682736 6145079 complement(4086524..4087258) 1 NC_010498.1 identified by similarity to SP:P05461; glycoprotein 3, capsid size determination protein Sid 4087258 sid 6145079 sid Escherichia coli SMS-3-5 glycoprotein 3, capsid size determination protein Sid YP_001745968.1 4086524 R 439855 CDS YP_001745969.1 170682956 6146944 4087811..4088077 1 NC_010498.1 identified by match to protein family HMM PF05930; AlpA family transcriptional regulator 4088077 6146944 EcSMS35_4006 Escherichia coli SMS-3-5 AlpA family transcriptional regulator YP_001745969.1 4087811 D 439855 CDS YP_001745970.1 170683926 6147171 4088260..4088664 1 NC_010498.1 identified by similarity to SP:P05462; phage protein 4088664 6147171 EcSMS35_4007 Escherichia coli SMS-3-5 phage protein YP_001745970.1 4088260 D 439855 CDS YP_001745971.1 170682460 6143222 4088657..4088944 1 NC_010498.1 identified by similarity to SP:P05463; hypothetical protein 4088944 6143222 EcSMS35_4008 Escherichia coli SMS-3-5 hypothetical protein YP_001745971.1 4088657 D 439855 CDS YP_001745972.1 170684141 6146659 4088937..4089392 1 NC_010498.1 identified by similarity to SP:P68663; hypothetical protein 4089392 6146659 EcSMS35_4009 Escherichia coli SMS-3-5 hypothetical protein YP_001745972.1 4088937 D 439855 CDS YP_001745973.1 170683217 6143441 4089528..4089848 1 NC_010498.1 identified by similarity to SP:P68665; hypothetical protein 4089848 6143441 EcSMS35_4010 Escherichia coli SMS-3-5 hypothetical protein YP_001745973.1 4089528 D 439855 CDS YP_001745974.1 170679915 6147438 4089863..4092196 1 NC_010498.1 identified by match to protein family HMM PF01751; match to protein family HMM PF03288; match to protein family HMM PF08273; match to protein family HMM PF08706; match to protein family HMM TIGR01613; D5 family nucleoside triphosphatase 4092196 6147438 EcSMS35_4012 Escherichia coli SMS-3-5 D5 family nucleoside triphosphatase YP_001745974.1 4089863 D 439855 CDS YP_001745975.1 170680168 6144077 complement(4092151..4092267) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4092267 6144077 EcSMS35_4011 Escherichia coli SMS-3-5 hypothetical protein YP_001745975.1 4092151 R 439855 CDS YP_001745976.1 170683656 6144334 4092783..4092929 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4092929 6144334 EcSMS35_4013 Escherichia coli SMS-3-5 hypothetical protein YP_001745976.1 4092783 D 439855 CDS YP_001745977.1 170683995 6142948 4093311..4094495 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter C 4094495 setC 6142948 setC Escherichia coli SMS-3-5 sugar efflux transporter C YP_001745977.1 4093311 D 439855 CDS YP_001745978.1 170682291 6143293 4094606..4095529 1 NC_010498.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; carboxylate/amino acid/amine transporter 4095529 6143293 EcSMS35_4015 Escherichia coli SMS-3-5 carboxylate/amino acid/amine transporter YP_001745978.1 4094606 D 439855 CDS YP_001745979.1 170680545 6146490 complement(4095533..4096351) 1 NC_010498.1 identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363; cytoplasmic membrane lipoprotein-28 4096351 nlpA 6146490 nlpA Escherichia coli SMS-3-5 cytoplasmic membrane lipoprotein-28 YP_001745979.1 4095533 R 439855 CDS YP_001745980.1 170681578 6144715 4096560..4096853 1 NC_010498.1 identified by similarity to SP:Q7CPG1; hypothetical protein 4096853 6144715 EcSMS35_4017 Escherichia coli SMS-3-5 hypothetical protein YP_001745980.1 4096560 D 439855 CDS YP_001745981.1 170681916 6145763 4097155..4097652 1 NC_010498.1 identified by match to protein family HMM PF07720; match to protein family HMM TIGR02552; putative type III secretion chaperone SicA 4097652 6145763 EcSMS35_4018 Escherichia coli SMS-3-5 putative type III secretion chaperone SicA YP_001745981.1 4097155 D 439855 CDS YP_001745982.1 170680244 6146111 4097662..4097844 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4097844 6146111 EcSMS35_4019 Escherichia coli SMS-3-5 hypothetical protein YP_001745982.1 4097662 D 439855 CDS YP_001745983.1 170681556 6144411 4097900..4099681 1 NC_010498.1 putative type III cell invasion protein SipB 4099681 6144411 EcSMS35_4020 Escherichia coli SMS-3-5 putative type III cell invasion protein SipB YP_001745983.1 4097900 D 439855 CDS YP_001745984.1 170680892 6145741 4099694..4100845 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4100845 6145741 EcSMS35_4021 Escherichia coli SMS-3-5 hypothetical protein YP_001745984.1 4099694 D 439855 CDS YP_001745985.1 170682977 6145070 4100889..4102238 1 NC_010498.1 putative type III effector protein SipD 4102238 6145070 EcSMS35_4022 Escherichia coli SMS-3-5 putative type III effector protein SipD YP_001745985.1 4100889 D 439855 CDS YP_001745986.1 170680759 6147192 4102441..4104138 1 NC_010498.1 Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system; invasion protein regulator 4104138 6147192 EcSMS35_4023 Escherichia coli SMS-3-5 invasion protein regulator YP_001745986.1 4102441 D 439855 CDS YP_001745987.1 170681141 6144934 complement(4104190..4112991) 1 NC_010498.1 identified by similarity to SP:P11922; match to protein family HMM PF02369; putative invasin 4112991 6144934 EcSMS35_4024 Escherichia coli SMS-3-5 putative invasin YP_001745987.1 4104190 R 439855 CDS YP_001745988.1 170681625 6145324 complement(4113194..4114378) 1 NC_010498.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4114378 nepI 6145324 nepI Escherichia coli SMS-3-5 ribonucleoside transporter YP_001745988.1 4113194 R 439855 CDS YP_001745989.1 170681508 6145810 4114612..4114965 1 NC_010498.1 identified by similarity to GB:CAE16839.1; match to protein family HMM PF06296; hypothetical protein 4114965 6145810 EcSMS35_4026 Escherichia coli SMS-3-5 hypothetical protein YP_001745989.1 4114612 D 439855 CDS YP_001745990.1 170682036 6145693 4114949..4115272 1 NC_010498.1 identified by match to protein family HMM PF01381; putative DNA-binding protein 4115272 6145693 EcSMS35_4027 Escherichia coli SMS-3-5 putative DNA-binding protein YP_001745990.1 4114949 D 439855 CDS YP_001745991.1 170683592 6146233 complement(4115388..4115840) 1 NC_010498.1 identified by match to protein family HMM PF06711; hypothetical protein 4115840 6146233 EcSMS35_4028 Escherichia coli SMS-3-5 hypothetical protein YP_001745991.1 4115388 R 439855 CDS YP_001745992.1 170683707 6142883 complement(4115893..4117239) 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease family inorganic anion transporter 4117239 6142883 EcSMS35_4029 Escherichia coli SMS-3-5 sulfate permease family inorganic anion transporter YP_001745992.1 4115893 R 439855 CDS YP_001745993.1 170680087 6142999 4117402..4119168 1 NC_010498.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4119168 ade 6142999 ade Escherichia coli SMS-3-5 cryptic adenine deaminase YP_001745993.1 4117402 D 439855 CDS YP_001745994.1 170680555 6144251 complement(4119215..4120606) 1 NC_010498.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4120606 uhpT 6144251 uhpT Escherichia coli SMS-3-5 sugar phosphate antiporter YP_001745994.1 4119215 R 439855 CDS YP_001745995.1 170679869 6144725 complement(4120744..4122063) 1 NC_010498.1 membrane protein regulates uhpT expression; regulatory protein UhpC 4122063 uhpC 6144725 uhpC Escherichia coli SMS-3-5 regulatory protein UhpC YP_001745995.1 4120744 R 439855 CDS YP_001745996.1 170679726 6144031 complement(4122073..4123575) 1 NC_010498.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4123575 uhpB 6144031 uhpB Escherichia coli SMS-3-5 sensory histidine kinase UhpB YP_001745996.1 4122073 R 439855 CDS YP_001745997.1 170684214 6143884 complement(4123575..4124165) 1 NC_010498.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 4124165 uhpA 6143884 uhpA Escherichia coli SMS-3-5 DNA-binding transcriptional activator UhpA YP_001745997.1 4123575 R 439855 CDS YP_001745998.1 170683433 6143515 complement(4124327..4125829) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4125829 6143515 EcSMS35_4035 Escherichia coli SMS-3-5 hypothetical protein YP_001745998.1 4124327 R 439855 CDS YP_001745999.1 170682880 6142720 complement(4126045..4127340) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4127340 6142720 EcSMS35_4036 Escherichia coli SMS-3-5 hypothetical protein YP_001745999.1 4126045 R 439855 CDS YP_001746000.1 170684308 6147093 complement(4127603..4127893) 1 NC_010498.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4127893 ilvN 6147093 ilvN Escherichia coli SMS-3-5 acetolactate synthase 1 regulatory subunit YP_001746000.1 4127603 R 439855 CDS YP_001746001.1 170683518 6143610 complement(4127897..4129585) 1 NC_010498.1 identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118; acetolactate synthase catalytic subunit 4129585 ilvB 6143610 ilvB Escherichia coli SMS-3-5 acetolactate synthase catalytic subunit YP_001746001.1 4127897 R 439855 CDS YP_001746002.1 170682873 6142808 4130723..4131907 1 NC_010498.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4131907 emrD 6142808 emrD Escherichia coli SMS-3-5 multidrug resistance protein D YP_001746002.1 4130723 D 439855 CDS YP_001746003.1 170681558 6147086 complement(4131915..4132412) 1 NC_010498.1 hypothetical protein 4132412 6147086 EcSMS35_4040 Escherichia coli SMS-3-5 hypothetical protein YP_001746003.1 4131915 R 439855 CDS YP_001746004.1 170681537 6145743 complement(4132409..4132771) 1 NC_010498.1 hypothetical protein 4132771 6145743 EcSMS35_4041 Escherichia coli SMS-3-5 hypothetical protein YP_001746004.1 4132409 R 439855 CDS YP_001746005.1 170680912 6145722 complement(4132761..4133108) 1 NC_010498.1 identified by match to protein family HMM PF02656; hypothetical protein 4133108 6145722 EcSMS35_4042 Escherichia coli SMS-3-5 hypothetical protein YP_001746005.1 4132761 R 439855 CDS YP_001746006.1 170681583 6145093 complement(4133168..4134661) 1 NC_010498.1 identified by match to protein family HMM PF00884; sulfatase 4134661 6145093 EcSMS35_4043 Escherichia coli SMS-3-5 sulfatase YP_001746006.1 4133168 R 439855 CDS YP_001746007.1 170680795 6145768 complement(4134658..4136373) 1 NC_010498.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK 4136373 6145768 EcSMS35_4044 Escherichia coli SMS-3-5 putative symporter YidK YP_001746007.1 4134658 R 439855 CDS YP_001746008.1 170679673 6144970 4136540..4137433 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 4137433 6144970 EcSMS35_4046 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001746008.1 4136540 D 439855 CDS YP_001746009.1 170680175 6143831 complement(4137430..4138752) 1 NC_010498.1 identified by match to protein family HMM PF02056; maltose-6'-phosphate glucosidase 4138752 glvA 6143831 glvA Escherichia coli SMS-3-5 maltose-6'-phosphate glucosidase YP_001746009.1 4137430 R 439855 CDS YP_001746010.1 170684221 6144341 complement(4138752..4140368) 1 NC_010498.1 identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00852; match to protein family HMM TIGR02005; PTS system, alpha-glucoside-specific IIBC component 4140368 6144341 EcSMS35_4047 Escherichia coli SMS-3-5 PTS system, alpha-glucoside-specific IIBC component YP_001746010.1 4138752 R 439855 CDS YP_001746011.1 170682524 6143522 4140664..4141380 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 4141380 6143522 EcSMS35_4049 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001746011.1 4140664 D 439855 CDS YP_001746012.1 170683682 6146725 complement(4141377..4143038) 1 NC_010498.1 identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625; hypothetical protein 4143038 6146725 EcSMS35_4048 Escherichia coli SMS-3-5 hypothetical protein YP_001746012.1 4141377 R 439855 CDS YP_001746013.1 170682212 6142974 4143080..4143229 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4143229 6142974 EcSMS35_4050 Escherichia coli SMS-3-5 hypothetical protein YP_001746013.1 4143080 D 439855 CDS YP_001746014.1 170680963 6146411 complement(4143234..4143662) 1 NC_010498.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4143662 ibpB 6146411 ibpB Escherichia coli SMS-3-5 heat shock chaperone IbpB YP_001746014.1 4143234 R 439855 CDS YP_001746015.1 170680318 6145144 complement(4143774..4144187) 1 NC_010498.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4144187 ibpA 6145144 ibpA Escherichia coli SMS-3-5 heat shock protein IbpA YP_001746015.1 4143774 R 439855 CDS YP_001746016.1 170681049 6144486 4144565..4144825 1 NC_010498.1 identified by match to protein family HMM PF07119; hypothetical protein 4144825 6144486 EcSMS35_4053 Escherichia coli SMS-3-5 hypothetical protein YP_001746016.1 4144565 D 439855 CDS YP_001746017.1 170681741 6145230 complement(4144827..4146041) 1 NC_010498.1 hypothetical protein 4146041 6145230 EcSMS35_4054 Escherichia coli SMS-3-5 hypothetical protein YP_001746017.1 4144827 R 439855 CDS YP_001746018.1 170681012 6145930 4146121..4147206 1 NC_010498.1 FAD/NAD(P)-binding domain; putative oxidoreductase 4147206 6145930 EcSMS35_4056 Escherichia coli SMS-3-5 putative oxidoreductase YP_001746018.1 4146121 D 439855 CDS YP_001746019.1 170682764 6145193 complement(4147203..4148495) 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881; match to protein family HMM TIGR00893; d-galactonate transporter 4148495 6145193 EcSMS35_4055 Escherichia coli SMS-3-5 d-galactonate transporter YP_001746019.1 4147203 R 439855 CDS YP_001746020.1 170682934 6146973 complement(4148615..4149763) 1 NC_010498.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746; galactonate dehydratase 4149763 6146973 EcSMS35_4057 Escherichia coli SMS-3-5 galactonate dehydratase YP_001746020.1 4148615 R 439855 CDS YP_001746021.1 170681080 6147148 complement(4149760..4150377) 1 NC_010498.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4150377 6147148 EcSMS35_4058 Escherichia coli SMS-3-5 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_001746021.1 4149760 R 439855 CDS YP_001746022.1 170682158 6145262 complement(4150361..4151239) 1 NC_010498.1 identified by similarity to SP:P31459; match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase 4151239 dgoK_1 6145262 dgoK_1 Escherichia coli SMS-3-5 2-dehydro-3-deoxygalactonokinase YP_001746022.1 4150361 R 439855 CDS YP_001746023.1 170682667 6146357 complement(4151236..4151925) 1 NC_010498.1 identified by similarity to SP:P31460; match to protein family HMM PF00392; match to protein family HMM PF07729; galactonate operon transcriptional repressor 4151925 dgoR_1 6146357 dgoR_1 Escherichia coli SMS-3-5 galactonate operon transcriptional repressor YP_001746023.1 4151236 R 439855 CDS YP_001746024.1 170680341 6146874 4152204..4152860 1 NC_010498.1 hypothetical protein 4152860 6146874 EcSMS35_4061 Escherichia coli SMS-3-5 hypothetical protein YP_001746024.1 4152204 D 439855 CDS YP_001746025.1 170683176 6144509 complement(4152904..4153716) 1 NC_010498.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4153716 yidA 6144509 yidA Escherichia coli SMS-3-5 sugar phosphatase YP_001746025.1 4152904 R 439855 CDS YP_001746026.1 170682981 6147396 complement(4153831..4154229) 1 NC_010498.1 identified by match to protein family HMM PF06078; hypothetical protein 4154229 6147396 EcSMS35_4063 Escherichia coli SMS-3-5 hypothetical protein YP_001746026.1 4153831 R 439855 CDS YP_001746027.1 170680955 6147196 complement(4154373..4156787) 1 NC_010498.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4156787 gyrB 6147196 gyrB Escherichia coli SMS-3-5 DNA gyrase subunit B YP_001746027.1 4154373 R 439855 CDS YP_001746028.1 170684195 6145136 complement(4156816..4157889) 1 NC_010498.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4157889 recF 6145136 recF Escherichia coli SMS-3-5 recombination protein F YP_001746028.1 4156816 R 439855 CDS YP_001746029.1 170682488 6143496 complement(4157889..4158989) 1 NC_010498.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4158989 dnaN 6143496 dnaN Escherichia coli SMS-3-5 DNA polymerase III subunit beta YP_001746029.1 4157889 R 439855 CDS YP_001746030.1 170679718 6146687 complement(4158994..4160397) 1 NC_010498.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 4160397 dnaA 6146687 dnaA Escherichia coli SMS-3-5 chromosomal replication initiation protein YP_001746030.1 4158994 R 439855 CDS YP_001746031.1 170680213 6143876 complement(4160691..4160891) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4160891 6143876 EcSMS35_4068 Escherichia coli SMS-3-5 hypothetical protein YP_001746031.1 4160691 R 439855 CDS YP_001746032.1 170680934 6144379 complement(4160911..4161051) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4161051 6144379 EcSMS35_4069 Escherichia coli SMS-3-5 hypothetical protein YP_001746032.1 4160911 R 439855 CDS YP_001746033.1 170681486 6145115 4161004..4161144 1 NC_010498.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4161144 rpmH 6145115 rpmH Escherichia coli SMS-3-5 50S ribosomal protein L34 YP_001746033.1 4161004 D 439855 CDS YP_001746034.1 170679855 6145671 4161161..4161520 1 NC_010498.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4161520 rnpA 6145671 rnpA Escherichia coli SMS-3-5 ribonuclease P YP_001746034.1 4161161 D 439855 CDS YP_001746035.1 170680368 6144017 4161744..4163390 1 NC_010498.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 4163390 6144017 EcSMS35_4072 Escherichia coli SMS-3-5 putative inner membrane protein translocase component YidC YP_001746035.1 4161744 D 439855 CDS YP_001746036.1 170681108 6144536 4163496..4164860 1 NC_010498.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4164860 trmE 6144536 trmE Escherichia coli SMS-3-5 tRNA modification GTPase TrmE YP_001746036.1 4163496 D 439855 CDS YP_001746037.1 170680908 6145291 4165102..4165176 1 NC_010498.1 identified by similarity to SP:P0AD89; match to protein family HMM TIGR02616; tryptophanase leader peptide 4165176 tnaC 6145291 tnaC Escherichia coli SMS-3-5 tryptophanase leader peptide YP_001746037.1 4165102 D 439855 CDS YP_001746038.1 170681687 6145087 4165397..4166812 1 NC_010498.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4166812 tnaA 6145087 tnaA Escherichia coli SMS-3-5 tryptophanase YP_001746038.1 4165397 D 439855 CDS YP_001746039.1 170680918 6146957 4168283..4169458 1 NC_010498.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4169458 mdtL 6146957 mdtL Escherichia coli SMS-3-5 multidrug efflux system protein MdtL YP_001746039.1 4168283 D 439855 CDS YP_001746040.1 170681541 6145099 4169433..4170392 1 NC_010498.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4170392 6145099 EcSMS35_4078 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator YidZ YP_001746040.1 4169433 D 439855 CDS YP_001746041.1 170682229 6145726 4170549..4171298 1 NC_010498.1 hypothetical protein 4171298 6145726 EcSMS35_4079 Escherichia coli SMS-3-5 hypothetical protein YP_001746041.1 4170549 D 439855 CDS YP_001746042.1 170682950 6146428 4171320..4171886 1 NC_010498.1 identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase 4171886 6146428 EcSMS35_4080 Escherichia coli SMS-3-5 NADPH-dependent FMN reductase YP_001746042.1 4171320 D 439855 CDS YP_001746043.1 170683636 6147165 complement(4171940..4173277) 1 NC_010498.1 identified by match to protein family HMM PF00860; sulfate permease family inorganic anion transporter 4173277 6147165 EcSMS35_4081 Escherichia coli SMS-3-5 sulfate permease family inorganic anion transporter YP_001746043.1 4171940 R 439855 CDS YP_001746044.1 170684177 6142927 4173444..4174109 1 NC_010498.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4174109 6142927 EcSMS35_4082 Escherichia coli SMS-3-5 6-phosphogluconate phosphatase YP_001746044.1 4173444 D 439855 CDS YP_001746045.1 170682228 6143478 complement(4174246..4176654) 1 NC_010498.1 identified by similarity to GB:ABB63945.1; hypothetical protein 4176654 6143478 EcSMS35_4083 Escherichia coli SMS-3-5 hypothetical protein YP_001746045.1 4174246 R 439855 CDS YP_001746046.1 170682949 6146427 complement(4176786..4176899) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4176899 6146427 EcSMS35_4084 Escherichia coli SMS-3-5 hypothetical protein YP_001746046.1 4176786 R 439855 CDS YP_001746047.1 170681129 6147164 4176955..4178142 1 NC_010498.1 identified by similarity to GB:ABG83000.1; hypothetical protein 4178142 6147164 EcSMS35_4085 Escherichia coli SMS-3-5 hypothetical protein YP_001746047.1 4176955 D 439855 CDS YP_001746048.1 170681631 6145312 complement(4178612..4181101) 1 NC_010498.1 identified by similarity to GB:ABB63945.1; hypothetical protein 4181101 6145312 EcSMS35_4086 Escherichia coli SMS-3-5 hypothetical protein YP_001746048.1 4178612 R 439855 CDS YP_001746049.1 170682776 6145816 complement(4181261..4181374) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4181374 6145816 EcSMS35_4087 Escherichia coli SMS-3-5 hypothetical protein YP_001746049.1 4181261 R 439855 CDS YP_001746050.1 170683229 6146985 complement(4181528..4182253) 1 NC_010498.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4182253 phoU 6146985 phoU Escherichia coli SMS-3-5 transcriptional regulator PhoU YP_001746050.1 4181528 R 439855 CDS YP_001746051.1 170683780 6147450 complement(4182268..4183041) 1 NC_010498.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4183041 pstB 6147450 pstB Escherichia coli SMS-3-5 phosphate transporter ATP-binding protein YP_001746051.1 4182268 R 439855 CDS YP_001746052.1 170679588 6143072 complement(4183131..4184021) 1 NC_010498.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4184021 pstA 6143072 pstA Escherichia coli SMS-3-5 phosphate transporter permease subunit PtsA YP_001746052.1 4183131 R 439855 CDS YP_001746053.1 170680226 6143745 complement(4184021..4184980) 1 NC_010498.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4184980 pstC 6143745 pstC Escherichia coli SMS-3-5 phosphate transporter permease subunit PstC YP_001746053.1 4184021 R 439855 CDS YP_001746054.1 170680926 6144392 complement(4185067..4186107) 1 NC_010498.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00975; phosphate ABC transporter periplasmic substrate-binding protein PstS 4186107 pstS 6144392 pstS Escherichia coli SMS-3-5 phosphate ABC transporter periplasmic substrate-binding protein PstS YP_001746054.1 4185067 R 439855 CDS YP_001746055.1 170683702 6145107 complement(4186355..4187425) 1 NC_010498.1 identified by similarity to GB:AAL18164.1; long polar fimbrial operon protein LpfD 4187425 lpfD 6145107 lpfD Escherichia coli SMS-3-5 long polar fimbrial operon protein LpfD YP_001746055.1 4186355 R 439855 CDS YP_001746056.1 170684256 6142994 complement(4187436..4189958) 1 NC_010498.1 identified by similarity to GB:AAL18163.1; match to protein family HMM PF00577; long polar fimbrial operon protein LpfC 4189958 lpfC 6142994 lpfC Escherichia coli SMS-3-5 long polar fimbrial operon protein LpfC YP_001746056.1 4187436 R 439855 CDS YP_001746057.1 170681205 6143558 complement(4189983..4190714) 1 NC_010498.1 identified by similarity to GB:AAL18162.1; match to protein family HMM PF00345; match to protein family HMM PF02753; long polar fimbrial operon protein LpfB 4190714 lpfB 6143558 lpfB Escherichia coli SMS-3-5 long polar fimbrial operon protein LpfB YP_001746057.1 4189983 R 439855 CDS YP_001746058.1 170680528 6145389 complement(4190762..4191334) 1 NC_010498.1 identified by match to protein family HMM PF00419; long polar fimbrial operon protein LpfA 4191334 lpfA 6145389 lpfA Escherichia coli SMS-3-5 long polar fimbrial operon protein LpfA YP_001746058.1 4190762 R 439855 CDS YP_001746059.1 170681402 6144698 complement(4191642..4193471) 1 NC_010498.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4193471 glmS 6144698 glmS Escherichia coli SMS-3-5 glucosamine--fructose-6-phosphate aminotransferase YP_001746059.1 4191642 R 439855 CDS YP_001746060.1 170679754 6145586 complement(4193633..4195003) 1 NC_010498.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4195003 glmU 6145586 glmU Escherichia coli SMS-3-5 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_001746060.1 4193633 R 439855 CDS YP_001746061.1 170682907 6143912 complement(4195352..4195771) 1 NC_010498.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 4195771 atpC 6143912 atpC Escherichia coli SMS-3-5 F0F1 ATP synthase subunit epsilon YP_001746061.1 4195352 R 439855 CDS YP_001746062.1 170681189 6147121 complement(4195792..4197174) 1 NC_010498.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 4197174 atpD 6147121 atpD Escherichia coli SMS-3-5 F0F1 ATP synthase subunit beta YP_001746062.1 4195792 R 439855 CDS YP_001746063.1 170684229 6145373 complement(4197201..4198064) 1 NC_010498.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 4198064 atpG 6145373 atpG Escherichia coli SMS-3-5 F0F1 ATP synthase subunit gamma YP_001746063.1 4197201 R 439855 CDS YP_001746064.1 170682498 6143530 complement(4198115..4199656) 1 NC_010498.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 4199656 atpA 6143530 atpA Escherichia coli SMS-3-5 F0F1 ATP synthase subunit alpha YP_001746064.1 4198115 R 439855 CDS YP_001746065.1 170679909 6146698 complement(4199669..4200202) 1 NC_010498.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 4200202 atpH 6146698 atpH Escherichia coli SMS-3-5 F0F1 ATP synthase subunit delta YP_001746065.1 4199669 R 439855 CDS YP_001746066.1 170680530 6144071 complement(4200217..4200687) 1 NC_010498.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 4200687 atpF 6144071 atpF Escherichia coli SMS-3-5 F0F1 ATP synthase subunit B YP_001746066.1 4200217 R 439855 CDS YP_001746067.1 170681273 6144700 complement(4200749..4200988) 1 NC_010498.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 4200988 atpE 6144700 atpE Escherichia coli SMS-3-5 F0F1 ATP synthase subunit C YP_001746067.1 4200749 R 439855 CDS YP_001746068.1 170681900 6145457 complement(4201035..4201850) 1 NC_010498.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 4201850 atpB 6145457 atpB Escherichia coli SMS-3-5 F0F1 ATP synthase subunit A YP_001746068.1 4201035 R 439855 CDS YP_001746069.1 170683722 6146095 complement(4201859..4202077) 1 NC_010498.1 identified by match to protein family HMM PF03899; ATP synthase F0, I subunit 4202077 atpI 6146095 atpI Escherichia coli SMS-3-5 ATP synthase F0, I subunit YP_001746069.1 4201859 R 439855 CDS YP_001746070.1 170682169 6143014 complement(4202856..4203479) 1 NC_010498.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4203479 gidB 6143014 gidB Escherichia coli SMS-3-5 16S rRNA methyltransferase GidB YP_001746070.1 4202856 R 439855 CDS YP_001746071.1 170680590 6146368 complement(4203543..4205432) 1 NC_010498.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 4205432 gidA 6146368 gidA Escherichia coli SMS-3-5 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_001746071.1 4203543 R 439855 CDS YP_001746072.1 170683215 6144762 complement(4205811..4206254) 1 NC_010498.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4206254 mioC 6144762 mioC Escherichia coli SMS-3-5 flavodoxin YP_001746072.1 4205811 R 439855 CDS YP_001746073.1 170680155 6147436 complement(4206344..4206802) 1 NC_010498.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4206802 asnC 6147436 asnC Escherichia coli SMS-3-5 DNA-binding transcriptional regulator AsnC YP_001746073.1 4206344 R 439855 CDS YP_001746074.1 170683630 6144321 4206954..4207946 1 NC_010498.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4207946 asnA 6144321 asnA Escherichia coli SMS-3-5 asparagine synthetase AsnA YP_001746074.1 4206954 D 439855 CDS YP_001746075.1 170683973 6142921 complement(4207951..4209402) 1 NC_010498.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4209402 yieM 6142921 yieM Escherichia coli SMS-3-5 hypothetical protein YP_001746075.1 4207951 R 439855 CDS YP_001746076.1 170679686 6143270 complement(4209396..4210892) 1 NC_010498.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4210892 6143270 EcSMS35_4114 Escherichia coli SMS-3-5 regulatory ATPase RavA YP_001746076.1 4209396 R 439855 CDS YP_001746077.1 170682987 6143844 4211115..4212983 1 NC_010498.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4212983 trkD 6143844 trkD Escherichia coli SMS-3-5 potassium transport protein Kup YP_001746077.1 4211115 D 439855 CDS YP_001746078.1 170683192 6147203 4213138..4213569 1 NC_010498.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4213569 rbsD 6147203 rbsD Escherichia coli SMS-3-5 D-ribose pyranase YP_001746078.1 4213138 D 439855 CDS YP_001746079.1 170682444 6147412 4213577..4215082 1 NC_010498.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4215082 rbsA 6147412 rbsA Escherichia coli SMS-3-5 D-ribose transporter ATP binding protein YP_001746079.1 4213577 D 439855 CDS YP_001746080.1 170683105 6146643 4215087..4216052 1 NC_010498.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4216052 rbsC 6146643 rbsC Escherichia coli SMS-3-5 ribose ABC transporter permease YP_001746080.1 4215087 D 439855 CDS YP_001746081.1 170681554 6147324 4216077..4216967 1 NC_010498.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4216967 rbsB 6147324 rbsB Escherichia coli SMS-3-5 D-ribose transporter subunit RbsB YP_001746081.1 4216077 D 439855 CDS YP_001746082.1 170681947 6145739 4217078..4218022 1 NC_010498.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4218022 rbsK 6145739 rbsK Escherichia coli SMS-3-5 ribokinase YP_001746082.1 4217078 D 439855 CDS YP_001746083.1 170680451 6146143 4218026..4219018 1 NC_010498.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4219018 rbsR 6146143 rbsR Escherichia coli SMS-3-5 transcriptional repressor RbsR YP_001746083.1 4218026 D 439855 CDS YP_001746084.1 170679741 6144620 complement(4218984..4220411) 1 NC_010498.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; DHA2 family drug:H+ antiporter-1 4220411 6144620 EcSMS35_4121 Escherichia coli SMS-3-5 DHA2 family drug:H+ antiporter-1 YP_001746084.1 4218984 R 439855 CDS YP_001746085.1 170681987 6143899 complement(4220434..4221126) 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 4221126 6143899 EcSMS35_4123 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001746085.1 4220434 R 439855 CDS YP_001746086.1 170682999 6143655 complement(4226916..4227755) 1 NC_010498.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4227755 hdfR 6143655 hdfR Escherichia coli SMS-3-5 transcriptional regulator HdfR YP_001746086.1 4226916 R 439855 CDS YP_001746087.1 170682455 6147215 4227874..4228212 1 NC_010498.1 identified by match to protein family HMM PF04219; hypothetical protein 4228212 6147215 EcSMS35_4132 Escherichia coli SMS-3-5 hypothetical protein YP_001746087.1 4227874 D 439855 CDS YP_001746088.1 170680083 6146654 complement(4228237..4229757) 1 NC_010498.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease 4229757 6146654 EcSMS35_4133 Escherichia coli SMS-3-5 putative ATP-dependent protease YP_001746088.1 4228237 R 439855 CDS YP_001746089.1 170684034 6144247 4230348..4231994 1 NC_010498.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4231994 ilvG 6144247 ilvG Escherichia coli SMS-3-5 acetolactate synthase 2 catalytic subunit YP_001746089.1 4230348 D 439855 CDS YP_001746090.1 170681121 6143333 4231991..4232254 1 NC_010498.1 acetolactate synthase 2 regulatory subunit 4232254 ilvM 6143333 ilvM Escherichia coli SMS-3-5 acetolactate synthase 2 regulatory subunit YP_001746090.1 4231991 D 439855 CDS YP_001746091.1 170680330 6145304 4232274..4233203 1 NC_010498.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4233203 ilvE 6145304 ilvE Escherichia coli SMS-3-5 branched-chain amino acid aminotransferase YP_001746091.1 4232274 D 439855 CDS YP_001746092.1 170682714 6144498 4233268..4235118 1 NC_010498.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4235118 ilvD 6144498 ilvD Escherichia coli SMS-3-5 dihydroxy-acid dehydratase YP_001746092.1 4233268 D 439855 CDS YP_001746093.1 170680546 6146922 4235118..4236665 1 NC_010498.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4236665 ilvA 6146922 ilvA Escherichia coli SMS-3-5 threonine dehydratase YP_001746093.1 4235118 D 439855 CDS YP_001746094.1 170682183 6144716 complement(4236662..4237552) 1 NC_010498.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4237552 ilvY 6144716 ilvY Escherichia coli SMS-3-5 DNA-binding transcriptional regulator IlvY YP_001746094.1 4236662 R 439855 CDS YP_001746095.1 170683905 6146382 4237702..4239177 1 NC_010498.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4239177 ilvC 6146382 ilvC Escherichia coli SMS-3-5 ketol-acid reductoisomerase YP_001746095.1 4237702 D 439855 CDS YP_001746096.1 170682547 6143201 complement(4239223..4239504) 1 NC_010498.1 identified by match to protein family HMM PF00639; peptidyl-prolyl cis-trans isomerase C 4239504 ppiC 6143201 ppiC Escherichia coli SMS-3-5 peptidyl-prolyl cis-trans isomerase C YP_001746096.1 4239223 R 439855 CDS YP_001746097.1 170680827 6146748 4240324..4242345 1 NC_010498.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4242345 rep 6146748 rep Escherichia coli SMS-3-5 ATP-dependent DNA helicase Rep YP_001746097.1 4240324 D 439855 CDS YP_001746098.1 170681890 6145004 complement(4242392..4243876) 1 NC_010498.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4243876 gppA 6145004 gppA Escherichia coli SMS-3-5 guanosine pentaphosphate phosphohydrolase YP_001746098.1 4242392 R 439855 CDS YP_001746099.1 170679910 6146084 complement(4244012..4245277) 1 NC_010498.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4245277 rhlB 6146084 rhlB Escherichia coli SMS-3-5 ATP-dependent RNA helicase RhlB YP_001746099.1 4244012 R 439855 CDS YP_001746100.1 170680473 6144072 4245408..4245737 1 NC_010498.1 identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 4245737 trxA 6144072 trxA Escherichia coli SMS-3-5 thioredoxin YP_001746100.1 4245408 D 439855 CDS YP_001746101.1 170683673 6144642 4246064..4247323 1 NC_010498.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4247323 rho 6144642 rho Escherichia coli SMS-3-5 transcription termination factor Rho YP_001746101.1 4246064 D 439855 CDS YP_001746102.1 170684201 6142965 4247333..4247551 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4247551 6142965 EcSMS35_4147 Escherichia coli SMS-3-5 hypothetical protein YP_001746102.1 4247333 D 439855 CDS YP_001746103.1 170682041 6143502 4247563..4248666 1 NC_010498.1 identified by match to protein family HMM PF00953; match to protein family HMM TIGR02380; undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase 4248666 wecA 6143502 wecA Escherichia coli SMS-3-5 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase YP_001746103.1 4247563 D 439855 CDS YP_001746104.1 170682919 6146238 4248678..4249724 1 NC_010498.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4249724 6146238 EcSMS35_4149 Escherichia coli SMS-3-5 lipopolysaccharide biosynthesis protein WzzE YP_001746104.1 4248678 D 439855 CDS YP_001746105.1 170682256 6147133 4249780..4250910 1 NC_010498.1 identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 4250910 6147133 EcSMS35_4150 Escherichia coli SMS-3-5 UDP-N-acetylglucosamine 2-epimerase YP_001746105.1 4249780 D 439855 CDS YP_001746106.1 170684251 6146455 4250907..4252169 1 NC_010498.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4252169 wecC 6146455 wecC Escherichia coli SMS-3-5 UDP-N-acetyl-D-mannosamine dehydrogenase YP_001746106.1 4250907 D 439855 CDS YP_001746107.1 170683610 6143553 4252169..4253236 1 NC_010498.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 4253236 rfbB2 6143553 rfbB2 Escherichia coli SMS-3-5 dTDP-glucose 4,6-dehydratase YP_001746107.1 4252169 D 439855 CDS YP_001746108.1 170680051 6142900 4253255..4254136 1 NC_010498.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 4254136 rfbA 6142900 rfbA Escherichia coli SMS-3-5 glucose-1-phosphate thymidylyltransferase YP_001746108.1 4253255 D 439855 CDS YP_001746109.1 170681802 6144215 4254114..4254788 1 NC_010498.1 identified by match to protein family HMM PF00583; match to protein family HMM TIGR02382; TDP-fucosamine acetyltransferase 4254788 wecD 6144215 wecD Escherichia coli SMS-3-5 TDP-fucosamine acetyltransferase YP_001746109.1 4254114 D 439855 CDS YP_001746110.1 170681601 6145995 4254793..4255923 1 NC_010498.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4255923 wecE 6145995 wecE Escherichia coli SMS-3-5 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_001746110.1 4254793 D 439855 CDS YP_001746111.1 170680789 6145786 4255925..4257175 1 NC_010498.1 identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein 4257175 6145786 EcSMS35_4156 Escherichia coli SMS-3-5 polysaccharide biosynthesis protein YP_001746111.1 4255925 D 439855 CDS YP_001746112.1 170682089 6144964 4257172..4258251 1 NC_010498.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4258251 wecF 6144964 wecF Escherichia coli SMS-3-5 4-alpha-L-fucosyltransferase YP_001746112.1 4257172 D 439855 CDS YP_001746113.1 170683948 6146286 4258248..4259600 1 NC_010498.1 enterobacterial common antigen polymerase; putative common antigen polymerase 4259600 wzyE 6146286 wzyE Escherichia coli SMS-3-5 putative common antigen polymerase YP_001746113.1 4258248 D 439855 CDS YP_001746114.1 170683664 6143244 4259603..4260343 1 NC_010498.1 identified by match to protein family HMM PF03808; match to protein family HMM TIGR00696; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 4260343 6143244 EcSMS35_4159 Escherichia coli SMS-3-5 putative UDP-N-acetyl-D-mannosaminuronic acid transferase YP_001746114.1 4259603 D 439855 CDS YP_001746115.1 170680511 6142956 4260534..4261919 1 NC_010498.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 4261919 6142956 EcSMS35_4160 Escherichia coli SMS-3-5 putative transport protein YifK YP_001746115.1 4260534 D 439855 CDS YP_001746116.1 170681829 6143689 4262605..4263840 1 NC_010498.1 identified by match to protein family HMM PF04055; arylsulfatase-activating protein AslB 4263840 aslB 6143689 aslB Escherichia coli SMS-3-5 arylsulfatase-activating protein AslB YP_001746116.1 4262605 D 439855 CDS YP_001746117.1 170681296 6146022 complement(4263998..4265653) 1 NC_010498.1 identified by similarity to SP:P25549; match to protein family HMM PF00884; arylsulfatase 4265653 aslA 6146022 aslA Escherichia coli SMS-3-5 arylsulfatase YP_001746117.1 4263998 R 439855 CDS YP_001746118.1 170682558 6145480 complement(4266317..4267513) 1 NC_010498.1 identified by match to protein family HMM PF07219; match to protein family HMM PF07719; match to protein family HMM TIGR00540; putative protoheme IX biogenesis protein 4267513 hemY 6145480 hemY Escherichia coli SMS-3-5 putative protoheme IX biogenesis protein YP_001746118.1 4266317 R 439855 CDS YP_001746119.1 170682020 6146761 complement(4267516..4268709) 1 NC_010498.1 identified by match to protein family HMM PF04375; putative uroporphyrinogen III C-methyltransferase 4268709 6146761 EcSMS35_4168 Escherichia coli SMS-3-5 putative uroporphyrinogen III C-methyltransferase YP_001746119.1 4267516 R 439855 CDS YP_001746120.1 170683392 6146217 complement(4268731..4269471) 1 NC_010498.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4269471 hemD 6146217 hemD Escherichia coli SMS-3-5 uroporphyrinogen-III synthase YP_001746120.1 4268731 R 439855 CDS YP_001746121.1 170680193 6142678 complement(4269468..4270424) 1 NC_010498.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4270424 hemC 6142678 hemC Escherichia coli SMS-3-5 porphobilinogen deaminase YP_001746121.1 4269468 R 439855 CDS YP_001746122.1 170679613 6144359 4270796..4273342 1 NC_010498.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4273342 cyaA 6144359 cyaA Escherichia coli SMS-3-5 adenylate cyclase YP_001746122.1 4270796 D 439855 CDS YP_001746123.1 170681576 6143770 complement(4273382..4273702) 1 NC_010498.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4273702 cyaY 6143770 cyaY Escherichia coli SMS-3-5 frataxin-like protein YP_001746123.1 4273382 R 439855 CDS YP_001746124.1 170682654 6145761 complement(4273750..4274013) 1 NC_010498.1 putative lipoprotein 4274013 6145761 EcSMS35_4173 Escherichia coli SMS-3-5 putative lipoprotein YP_001746124.1 4273750 R 439855 CDS YP_001746125.1 170681974 6146861 4274172..4274375 1 NC_010498.1 putative lipoprotein 4274375 6146861 EcSMS35_4174 Escherichia coli SMS-3-5 putative lipoprotein YP_001746125.1 4274172 D 439855 CDS YP_001746126.1 170683935 6146170 4274412..4275236 1 NC_010498.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4275236 dapF 6146170 dapF Escherichia coli SMS-3-5 diaminopimelate epimerase YP_001746126.1 4274412 D 439855 CDS YP_001746127.1 170683253 6143231 4275233..4275940 1 NC_010498.1 identified by match to protein family HMM PF04340; hypothetical protein 4275940 6143231 EcSMS35_4176 Escherichia coli SMS-3-5 hypothetical protein YP_001746127.1 4275233 D 439855 CDS YP_001746128.1 170683603 6147476 4275937..4276833 1 NC_010498.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4276833 xerC 6147476 xerC Escherichia coli SMS-3-5 site-specific tyrosine recombinase XerC YP_001746128.1 4275937 D 439855 CDS YP_001746129.1 170680482 6142893 4276833..4277549 1 NC_010498.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4277549 6142893 EcSMS35_4178 Escherichia coli SMS-3-5 flavin mononucleotide phosphatase YP_001746129.1 4276833 D 439855 CDS YP_001746130.1 170679582 6144651 4277633..4279795 1 NC_010498.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4279795 uvrD 6144651 uvrD Escherichia coli SMS-3-5 DNA-dependent helicase II YP_001746130.1 4277633 D 439855 CDS YP_001746131.1 170681390 6143739 complement(4279850..4280752) 1 NC_010498.1 identified by match to protein family HMM PF01887; hypothetical protein 4280752 6143739 EcSMS35_4180 Escherichia coli SMS-3-5 hypothetical protein YP_001746131.1 4279850 R 439855 CDS YP_001746132.1 170680837 6145574 complement(4280835..4281599) 1 NC_010498.1 hypothetical protein 4281599 6145574 EcSMS35_4181 Escherichia coli SMS-3-5 hypothetical protein YP_001746132.1 4280835 R 439855 CDS YP_001746133.1 170682665 6145014 4281612..4281725 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4281725 6145014 EcSMS35_4182 Escherichia coli SMS-3-5 hypothetical protein YP_001746133.1 4281612 D 439855 CDS YP_001746134.1 170680198 6146872 4281969..4282919 1 NC_010498.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4282919 corA 6146872 corA Escherichia coli SMS-3-5 magnesium/nickel/cobalt transporter CorA YP_001746134.1 4281969 D 439855 CDS YP_001746135.1 170679716 6144364 complement(4282955..4283452) 1 NC_010498.1 identified by match to protein family HMM PF06092; hypothetical protein 4283452 6144364 EcSMS35_4184 Escherichia coli SMS-3-5 hypothetical protein YP_001746135.1 4282955 R 439855 CDS YP_001746136.1 170684029 6143874 complement(4283449..4284297) 1 NC_010498.1 identified by match to protein family HMM TIGR03034; hypothetical protein 4284297 6143874 EcSMS35_4185 Escherichia coli SMS-3-5 hypothetical protein YP_001746136.1 4283449 R 439855 CDS YP_001746137.1 170683494 6143328 complement(4284607..4285497) 1 NC_010498.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00688; RarD protein 4285497 rarD 6143328 rarD Escherichia coli SMS-3-5 RarD protein YP_001746137.1 4284607 R 439855 CDS YP_001746138.1 170679742 6142783 complement(4285549..4286016) 1 NC_010498.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 4286016 6142783 EcSMS35_4187 Escherichia coli SMS-3-5 hypothetical protein YP_001746138.1 4285549 R 439855 CDS YP_001746139.1 170681373 6143900 4286181..4287050 1 NC_010498.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4287050 pldA 6143900 pldA Escherichia coli SMS-3-5 phospholipase A YP_001746139.1 4286181 D 439855 CDS YP_001746140.1 170680861 6145557 4287169..4289004 1 NC_010498.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4289004 recQ 6145557 recQ Escherichia coli SMS-3-5 ATP-dependent DNA helicase RecQ YP_001746140.1 4287169 D 439855 CDS YP_001746141.1 170683014 6145038 4289068..4289688 1 NC_010498.1 identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; threonine efflux system 4289688 rhtC 6145038 rhtC Escherichia coli SMS-3-5 threonine efflux system YP_001746141.1 4289068 D 439855 CDS YP_001746142.1 170682422 6147230 complement(4289750..4290370) 1 NC_010498.1 identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; homoserine/homoserine lactone efflux protein 4290370 rhtB 6147230 rhtB Escherichia coli SMS-3-5 homoserine/homoserine lactone efflux protein YP_001746142.1 4289750 R 439855 CDS YP_001746143.1 170684143 6146621 4290481..4291503 1 NC_010498.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4291503 pldB 6146621 pldB Escherichia coli SMS-3-5 lysophospholipase L2 YP_001746143.1 4290481 D 439855 CDS YP_001746144.1 170683030 6143443 4291511..4292311 1 NC_010498.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 4292311 6143443 EcSMS35_4193 Escherichia coli SMS-3-5 putative sugar phosphatase YP_001746144.1 4291511 D 439855 CDS YP_001746145.1 170682387 6147246 4292387..4293286 1 NC_010498.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; 10 TMS drug/metabolite exporter (DME) family protein 4293286 6147246 EcSMS35_4194 Escherichia coli SMS-3-5 10 TMS drug/metabolite exporter (DME) family protein YP_001746145.1 4292387 D 439855 CDS YP_001746146.1 170683914 6146586 4294245..4296506 1 NC_010498.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4296506 metE 6146586 metE Escherichia coli SMS-3-5 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_001746146.1 4294245 D 439855 CDS YP_001746147.1 170683410 6143210 complement(4296600..4297496) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 4297496 6143210 EcSMS35_4196 Escherichia coli SMS-3-5 LysR family transcriptional regulator YP_001746147.1 4296600 R 439855 CDS YP_001746148.1 170680197 6142696 complement(4297574..4298797) 1 NC_010498.1 identified by match to protein family HMM PF02133; cytosine/purines/uracil/thiamine/allantoin family permease 4298797 6142696 EcSMS35_4197 Escherichia coli SMS-3-5 cytosine/purines/uracil/thiamine/allantoin family permease YP_001746148.1 4297574 R 439855 CDS YP_001746149.1 170679844 6144363 complement(4298823..4299212) 1 NC_010498.1 identified by similarity to RF:NP_756622.1; hypothetical protein 4299212 6144363 EcSMS35_4198 Escherichia coli SMS-3-5 hypothetical protein YP_001746149.1 4298823 R 439855 CDS YP_001746150.1 170681211 6144006 complement(4299229..4300185) 1 NC_010498.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 4300185 6144006 EcSMS35_4199 Escherichia coli SMS-3-5 carbamate kinase YP_001746150.1 4299229 R 439855 CDS YP_001746151.1 170680799 6145395 complement(4300178..4301602) 1 NC_010498.1 identified by match to protein family HMM PF06545; hypothetical protein 4301602 6145395 EcSMS35_4200 Escherichia coli SMS-3-5 hypothetical protein YP_001746151.1 4300178 R 439855 CDS YP_001746152.1 170682351 6144975 complement(4301599..4303158) 1 NC_010498.1 identified by match to protein family HMM PF06263; acyl-CoA synthetase 4303158 6144975 EcSMS35_4201 Escherichia coli SMS-3-5 acyl-CoA synthetase YP_001746152.1 4301599 R 439855 CDS YP_001746153.1 170684276 6146550 complement(4303253..4304113) 1 NC_010498.1 identified by similarity to GB:AAZ87092.1; hypothetical protein 4304113 6146550 EcSMS35_4202 Escherichia coli SMS-3-5 hypothetical protein YP_001746153.1 4303253 R 439855 CDS YP_001746154.1 170680920 6143578 complement(4304119..4304787) 1 NC_010498.1 identified by match to protein family HMM PF00857; isochorismatase family protein 4304787 6143578 EcSMS35_4203 Escherichia coli SMS-3-5 isochorismatase family protein YP_001746154.1 4304119 R 439855 CDS YP_001746155.1 170681555 6145101 4304805..4304918 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4304918 6145101 EcSMS35_4204 Escherichia coli SMS-3-5 hypothetical protein YP_001746155.1 4304805 D 439855 CDS YP_001746156.1 170679678 6145740 4304897..4305013 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4305013 6145740 EcSMS35_4205 Escherichia coli SMS-3-5 hypothetical protein YP_001746156.1 4304897 D 439855 CDS YP_001746157.1 170680205 6143836 complement(4305044..4305853) 1 NC_010498.1 identified by match to protein family HMM PF01738; dienelactone hydrolase family protein 4305853 6143836 EcSMS35_4206 Escherichia coli SMS-3-5 dienelactone hydrolase family protein YP_001746157.1 4305044 R 439855 CDS YP_001746158.1 170683138 6144371 complement(4305985..4306101) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4306101 6144371 EcSMS35_4207 Escherichia coli SMS-3-5 hypothetical protein YP_001746158.1 4305985 R 439855 CDS YP_001746159.1 170683788 6147358 4306115..4306879 1 NC_010498.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4306879 udp 6147358 udp Escherichia coli SMS-3-5 uridine phosphorylase YP_001746159.1 4306115 D 439855 CDS YP_001746160.1 170682802 6143080 complement(4306913..4308403) 1 NC_010498.1 identified by match to protein family HMM PF01970; integral membrane protein 4308403 6143080 EcSMS35_4209 Escherichia coli SMS-3-5 integral membrane protein YP_001746160.1 4306913 R 439855 CDS YP_001746161.1 170680774 6147012 complement(4308416..4308922) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4308922 6147012 EcSMS35_4210 Escherichia coli SMS-3-5 hypothetical protein YP_001746161.1 4308416 R 439855 CDS YP_001746162.1 170681055 6144949 complement(4308939..4309913) 1 NC_010498.1 identified by match to protein family HMM PF03401; periplasmic binding protein 4309913 6144949 EcSMS35_4211 Escherichia coli SMS-3-5 periplasmic binding protein YP_001746162.1 4308939 R 439855 CDS YP_001746163.1 170679834 6145236 complement(4309938..4310567) 1 NC_010498.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4310567 6145236 EcSMS35_4212 Escherichia coli SMS-3-5 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_001746163.1 4309938 R 439855 CDS YP_001746164.1 170683717 6143996 complement(4310557..4311561) 1 NC_010498.1 identified by similarity to SP:P31459; match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase 4311561 6143996 EcSMS35_4213 Escherichia coli SMS-3-5 2-dehydro-3-deoxygalactonokinase YP_001746164.1 4310557 R 439855 CDS YP_001746165.1 170683184 6143009 complement(4311585..4312439) 1 NC_010498.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator 4312439 6143009 EcSMS35_4214 Escherichia coli SMS-3-5 IclR family transcriptional regulator YP_001746165.1 4311585 R 439855 CDS YP_001746166.1 170682711 6147404 4312569..4313996 1 NC_010498.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4313996 rmuC 6147404 rmuC Escherichia coli SMS-3-5 DNA recombination protein RmuC YP_001746166.1 4312569 D 439855 CDS YP_001746167.1 170682083 6146919 4314091..4314846 1 NC_010498.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4314846 ubiE 6146919 ubiE Escherichia coli SMS-3-5 ubiquinone/menaquinone biosynthesis methyltransferase YP_001746167.1 4314091 D 439855 CDS YP_001746168.1 170679770 6146280 4314860..4315465 1 NC_010498.1 identified by match to protein family HMM PF06843; hypothetical protein 4315465 6146280 EcSMS35_4217 Escherichia coli SMS-3-5 hypothetical protein YP_001746168.1 4314860 D 439855 CDS YP_001746169.1 170681731 6143929 4315462..4317102 1 NC_010498.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4317102 ubiB 6143929 ubiB Escherichia coli SMS-3-5 putative ubiquinone biosynthesis protein UbiB YP_001746169.1 4315462 D 439855 CDS YP_001746170.1 170683516 6145920 4317181..4317450 1 NC_010498.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4317450 tatA 6145920 tatA Escherichia coli SMS-3-5 twin arginine translocase protein A YP_001746170.1 4317181 D 439855 CDS YP_001746171.1 170680611 6142806 4317454..4317969 1 NC_010498.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4317969 tatB 6142806 tatB Escherichia coli SMS-3-5 sec-independent translocase YP_001746171.1 4317454 D 439855 CDS YP_001746172.1 170683092 6144785 4317972..4318748 1 NC_010498.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4318748 tatC 6144785 tatC Escherichia coli SMS-3-5 twin-arginine protein translocation system subunit TatC YP_001746172.1 4317972 D 439855 CDS YP_001746173.1 170684158 6147310 4318790..4319572 1 NC_010498.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4319572 tatD 6147310 tatD Escherichia coli SMS-3-5 DNase TatD YP_001746173.1 4318790 D 439855 CDS YP_001746174.1 170682425 6143458 complement(4319569..4320057) 1 NC_010498.1 identified by match to protein family HMM PF02357; match to protein family HMM TIGR01955; transcriptional activator RfaH 4320057 rfaH 6143458 rfaH Escherichia coli SMS-3-5 transcriptional activator RfaH YP_001746174.1 4319569 R 439855 CDS YP_001746175.1 170682759 6146624 4320224..4321717 1 NC_010498.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4321717 ubiD 6146624 ubiD Escherichia coli SMS-3-5 3-octaprenyl-4-hydroxybenzoate decarboxylase YP_001746175.1 4320224 D 439855 CDS YP_001746176.1 170683060 6146968 4321763..4322464 1 NC_010498.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4322464 fre 6146968 fre Escherichia coli SMS-3-5 FMN reductase YP_001746176.1 4321763 D 439855 CDS YP_001746177.1 170682404 6147277 complement(4322655..4323818) 1 NC_010498.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4323818 fadA 6147277 fadA Escherichia coli SMS-3-5 3-ketoacyl-CoA thiolase YP_001746177.1 4322655 R 439855 CDS YP_001746178.1 170684115 6146603 complement(4323828..4326017) 1 NC_010498.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4326017 fadB 6146603 fadB Escherichia coli SMS-3-5 multifunctional fatty acid oxidation complex subunit alpha YP_001746178.1 4323828 R 439855 CDS YP_001746179.1 170683404 6143415 4326207..4327538 1 NC_010498.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4327538 pepQ 6143415 pepQ Escherichia coli SMS-3-5 proline dipeptidase YP_001746179.1 4326207 D 439855 CDS YP_001746180.1 170681079 6142690 4327538..4328152 1 NC_010498.1 yigZ; identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 4328152 6142690 EcSMS35_4229 Escherichia coli SMS-3-5 hypothetical protein YP_001746180.1 4327538 D 439855 CDS YP_001746181.1 170679843 6145261 4328191..4329642 1 NC_010498.1 identified by match to protein family HMM PF02386; match to protein family HMM TIGR00933; potassium transporter 4329642 trkH 6145261 trkH Escherichia coli SMS-3-5 potassium transporter YP_001746181.1 4328191 D 439855 CDS YP_001746182.1 170681492 6144005 4329654..4330199 1 NC_010498.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4330199 hemG 6144005 hemG Escherichia coli SMS-3-5 protoporphyrinogen oxidase YP_001746182.1 4329654 D 439855 CDS YP_001746183.1 170680360 6143713 complement(4335689..4336216) 1 NC_010498.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4336216 mobB 6143713 mobB Escherichia coli SMS-3-5 molybdopterin-guanine dinucleotide biosynthesis protein B YP_001746183.1 4335689 R 439855 CDS YP_001746184.1 170683367 6144528 complement(4336198..4336782) 1 NC_010498.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4336782 mobA 6144528 mobA Escherichia coli SMS-3-5 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_001746184.1 4336198 R 439855 CDS YP_001746185.1 170681648 6142653 4336852..4337121 1 NC_010498.1 identified by match to protein family HMM PF06288; hypothetical protein 4337121 6142653 EcSMS35_4239 Escherichia coli SMS-3-5 hypothetical protein YP_001746185.1 4336852 D 439855 CDS YP_001746186.1 170680021 6145834 4337198..4338184 1 NC_010498.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4338184 6145834 EcSMS35_4240 Escherichia coli SMS-3-5 serine/threonine protein kinase YP_001746186.1 4337198 D 439855 CDS YP_001746187.1 170681207 6144184 4338201..4338827 1 NC_010498.1 identified by similarity to SP:P0AEG4; match to protein family HMM PF01323; periplasmic protein disulfide isomerase I 4338827 dsbA 6144184 dsbA Escherichia coli SMS-3-5 periplasmic protein disulfide isomerase I YP_001746187.1 4338201 D 439855 CDS YP_001746188.1 170680747 6145391 4338852..4338992 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4338992 6145391 EcSMS35_4242 Escherichia coli SMS-3-5 hypothetical protein YP_001746188.1 4338852 D 439855 CDS YP_001746189.1 170679865 6146290 complement(4340452..4341408) 1 NC_010498.1 identified by match to protein family HMM PF01553; putative acyltransferase 4341408 6146290 EcSMS35_4244 Escherichia coli SMS-3-5 putative acyltransferase YP_001746189.1 4340452 R 439855 CDS YP_001746190.1 170680525 6144027 complement(4341504..4341689) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4341689 6144027 EcSMS35_4245 Escherichia coli SMS-3-5 hypothetical protein YP_001746190.1 4341504 R 439855 CDS YP_001746191.1 170683498 6144695 4341748..4344534 1 NC_010498.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4344534 polA 6144695 polA Escherichia coli SMS-3-5 DNA polymerase I YP_001746191.1 4341748 D 439855 CDS YP_001746192.1 170680648 6142787 complement(4344753..4344902) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4344902 6142787 EcSMS35_4247 Escherichia coli SMS-3-5 hypothetical protein YP_001746192.1 4344753 R 439855 CDS YP_001746193.1 170683684 6144823 complement(4344916..4345548) 1 NC_010498.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4345548 engB 6144823 engB Escherichia coli SMS-3-5 ribosome biogenesis GTP-binding protein YsxC YP_001746193.1 4344916 R 439855 CDS YP_001746194.1 170680494 6142976 4346130..4346639 1 NC_010498.1 identified by match to protein family HMM PF04220; hypothetical protein 4346639 6142976 EcSMS35_4249 Escherichia coli SMS-3-5 hypothetical protein YP_001746194.1 4346130 D 439855 CDS YP_001746195.1 170683887 6144663 complement(4346713..4346829) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4346829 6144663 EcSMS35_4250 Escherichia coli SMS-3-5 hypothetical protein YP_001746195.1 4346713 R 439855 CDS YP_001746196.1 170683331 6143182 4346828..4348201 1 NC_010498.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4348201 hemN 6143182 hemN Escherichia coli SMS-3-5 coproporphyrinogen III oxidase YP_001746196.1 4346828 D 439855 CDS YP_001746197.1 170682532 6142616 complement(4348294..4348407) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4348407 6142616 EcSMS35_4252 Escherichia coli SMS-3-5 hypothetical protein YP_001746197.1 4348294 R 439855 CDS YP_001746198.1 170682005 6146733 complement(4348613..4350031) 1 NC_010498.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4350031 glnG 6146733 glnG Escherichia coli SMS-3-5 nitrogen regulation protein NR(I) YP_001746198.1 4348613 R 439855 CDS YP_001746199.1 170681876 6146202 complement(4350034..4351083) 1 NC_010498.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4351083 glnL 6146202 glnL Escherichia coli SMS-3-5 nitrogen regulation protein NR(II) YP_001746199.1 4350034 R 439855 CDS YP_001746200.1 170680848 6146070 complement(4351257..4352666) 1 NC_010498.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4352666 glnA 6146070 glnA Escherichia coli SMS-3-5 glutamine synthetase YP_001746200.1 4351257 R 439855 CDS YP_001746201.1 170683639 6145025 4353039..4354862 1 NC_010498.1 identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein 4354862 typA 6145025 typA Escherichia coli SMS-3-5 GTP-binding protein YP_001746201.1 4353039 D 439855 CDS YP_001746202.1 170683114 6142931 4355079..4355789 1 NC_010498.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 4355789 6142931 EcSMS35_4257 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001746202.1 4355079 D 439855 CDS YP_001746203.1 170682629 6147333 4355899..4356777 1 NC_010498.1 identified by match to protein family HMM PF01261; AP endonuclease 4356777 6147333 EcSMS35_4258 Escherichia coli SMS-3-5 AP endonuclease YP_001746203.1 4355899 D 439855 CDS YP_001746204.1 170682134 6146835 4356879..4358144 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 4358144 6146835 EcSMS35_4259 Escherichia coli SMS-3-5 major facilitator transporter YP_001746204.1 4356879 D 439855 CDS YP_001746205.1 170681579 6146333 complement(4358236..4358928) 1 NC_010498.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 4358928 ompL 6146333 ompL Escherichia coli SMS-3-5 outer membrane porin L YP_001746205.1 4358236 R 439855 CDS YP_001746206.1 170682275 6145764 complement(4358995..4360398) 1 NC_010498.1 identified by match to protein family HMM TIGR00792; sugar (glycoside-Pentoside-hexuronide) transporter family protein 4360398 6145764 EcSMS35_4261 Escherichia coli SMS-3-5 sugar (glycoside-Pentoside-hexuronide) transporter family protein YP_001746206.1 4358995 R 439855 CDS YP_001746207.1 170680543 6146474 complement(4360441..4361826) 1 NC_010498.1 identified by match to protein family HMM TIGR00792; sugar transporter family protein 4361826 6146474 EcSMS35_4262 Escherichia coli SMS-3-5 sugar transporter family protein YP_001746207.1 4360441 R 439855 CDS YP_001746208.1 170679942 6144713 complement(4361872..4363908) 1 NC_010498.1 identified by match to protein family HMM PF01055; alpha-glucosidase 4363908 6144713 EcSMS35_4263 Escherichia coli SMS-3-5 alpha-glucosidase YP_001746208.1 4361872 R 439855 CDS YP_001746209.1 170683996 6144104 complement(4364106..4365005) 1 NC_010498.1 identified by match to protein family HMM PF01263; aldose-1-epimerase family protein 4365005 6144104 EcSMS35_4264 Escherichia coli SMS-3-5 aldose-1-epimerase family protein YP_001746209.1 4364106 R 439855 CDS YP_001746210.1 170683291 6143294 complement(4365124..4366365) 1 NC_010498.1 identified by match to protein family HMM PF07221; N-acylglucosamine 2-epimerase 4366365 6143294 EcSMS35_4265 Escherichia coli SMS-3-5 N-acylglucosamine 2-epimerase YP_001746210.1 4365124 R 439855 CDS YP_001746211.1 170679919 6147517 complement(4366381..4367259) 1 NC_010498.1 identified by match to protein family HMM PF01791; deoxyribose-phosphate aldolase 4367259 6147517 EcSMS35_4266 Escherichia coli SMS-3-5 deoxyribose-phosphate aldolase YP_001746211.1 4366381 R 439855 CDS YP_001746212.1 170680542 6144081 complement(4367283..4368179) 1 NC_010498.1 identified by match to protein family HMM PF03446; 3-hydroxyisobutyrate dehydrogenase 4368179 6144081 EcSMS35_4267 Escherichia coli SMS-3-5 3-hydroxyisobutyrate dehydrogenase YP_001746212.1 4367283 R 439855 CDS YP_001746213.1 170683304 6144712 4368347..4369243 1 NC_010498.1 identified by match to protein family HMM PF00294; PfkB family kinase 4369243 6144712 EcSMS35_4268 Escherichia coli SMS-3-5 PfkB family kinase YP_001746213.1 4368347 D 439855 CDS YP_001746214.1 170683985 6147530 4369277..4370062 1 NC_010498.1 identified by match to protein family HMM PF00455; match to protein family HMM PF01022; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator 4370062 6147530 EcSMS35_4269 Escherichia coli SMS-3-5 DeoR family transcriptional regulator YP_001746214.1 4369277 D 439855 CDS YP_001746215.1 170681999 6143283 4370161..4370760 1 NC_010498.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; phosphatase 4370760 yihX 6143283 yihX Escherichia coli SMS-3-5 phosphatase YP_001746215.1 4370161 D 439855 CDS YP_001746216.1 170682650 6146195 4370754..4371626 1 NC_010498.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4371626 rbn 6146195 rbn Escherichia coli SMS-3-5 ribonuclease BN YP_001746216.1 4370754 D 439855 CDS YP_001746217.1 170680143 6146857 4371623..4372060 1 NC_010498.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4372060 dtd 6146857 dtd Escherichia coli SMS-3-5 D-tyrosyl-tRNA(Tyr) deacylase YP_001746217.1 4371623 D 439855 CDS YP_001746218.1 170680652 6144309 4372105..4373046 1 NC_010498.1 identified by match to protein family HMM PF00583; match to protein family HMM TIGR02447; acetyltransferase 4373046 6144309 EcSMS35_4273 Escherichia coli SMS-3-5 acetyltransferase YP_001746218.1 4372105 D 439855 CDS YP_001746219.1 170681178 6144827 4373462..4375276 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4375276 6144827 EcSMS35_4274 Escherichia coli SMS-3-5 hypothetical protein YP_001746219.1 4373462 D 439855 CDS YP_001746220.1 170681663 6145362 4375972..4376190 1 NC_010498.1 identified by match to protein family HMM PF01402; CopG family protein 4376190 6145362 EcSMS35_4275 Escherichia coli SMS-3-5 CopG family protein YP_001746220.1 4375972 D 439855 CDS YP_001746221.1 170681170 6145849 4376433..4376651 1 NC_010498.1 hypothetical protein 4376651 6145849 EcSMS35_4276 Escherichia coli SMS-3-5 hypothetical protein YP_001746221.1 4376433 D 439855 CDS YP_001746222.1 170681666 6145354 complement(4376980..4377909) 1 NC_010498.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4377909 fdhE 6145354 fdhE Escherichia coli SMS-3-5 formate dehydrogenase accessory protein FdhE YP_001746222.1 4376980 R 439855 CDS YP_001746223.1 170684266 6145852 complement(4377906..4378541) 1 NC_010498.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4378541 fdoI 6145852 fdoI Escherichia coli SMS-3-5 formate dehydrogenase-O subunit gamma YP_001746223.1 4377906 R 439855 CDS YP_001746224.1 170680015 6143568 complement(4378538..4379440) 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582; formate dehydrogenase-O, iron-sulfur subunit 4379440 fdoH 6143568 fdoH Escherichia coli SMS-3-5 formate dehydrogenase-O, iron-sulfur subunit YP_001746224.1 4378538 R 439855 CDS YP_001746225.1 170683127 6144178 complement(4379453..4382503) 1 NC_010498.1 Selenoprotein. identified by similarity to SP:P32176; match to protein family HMM PF04879; match to protein family HMM TIGR01409; formate dehydrogenase-O, major subunit, selenocysteine-containing 4382503 fdoG 6144178 fdoG Escherichia coli SMS-3-5 formate dehydrogenase-O, major subunit, selenocysteine-containing YP_001746225.1 4379453 R 439855 CDS YP_001746226.1 170681640 6147346 4382507..4382761 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4382761 6147346 EcSMS35_4281 Escherichia coli SMS-3-5 hypothetical protein YP_001746226.1 4382507 D 439855 CDS YP_001746227.1 170682352 6145826 4382730..4383533 1 NC_010498.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4383533 fdhD 6145826 fdhD Escherichia coli SMS-3-5 formate dehydrogenase accessory protein YP_001746227.1 4382730 D 439855 CDS YP_001746228.1 170680923 6146551 complement(4383727..4383852) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4383852 6146551 EcSMS35_4283 Escherichia coli SMS-3-5 hypothetical protein YP_001746228.1 4383727 R 439855 CDS YP_001746229.1 170681573 6145104 4383843..4385678 1 NC_010498.1 identified by similarity to GB:CAJ22947.1; hypothetical protein 4385678 6145104 EcSMS35_4284 Escherichia coli SMS-3-5 hypothetical protein YP_001746229.1 4383843 D 439855 CDS YP_001746230.1 170683619 6145758 4385680..4387986 1 NC_010498.1 identified by similarity to GB:ABJ10234.1; hypothetical protein 4387986 6145758 EcSMS35_4285 Escherichia coli SMS-3-5 hypothetical protein YP_001746230.1 4385680 D 439855 CDS YP_001746231.1 170683093 6142909 4388181..4389236 1 NC_010498.1 putative lipoprotein 4389236 6142909 EcSMS35_4286 Escherichia coli SMS-3-5 putative lipoprotein YP_001746231.1 4388181 D 439855 CDS YP_001746232.1 170683057 6147311 complement(4389292..4391040) 1 NC_010498.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein 4391040 6147311 EcSMS35_4287 Escherichia coli SMS-3-5 putative frv operon regulatory protein YP_001746232.1 4389292 R 439855 CDS YP_001746233.1 170683436 6147274 complement(4391040..4392110) 1 NC_010498.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX 4392110 6147274 EcSMS35_4288 Escherichia coli SMS-3-5 putative fructose-specific phosphotransferase system protein FrvX YP_001746233.1 4391040 R 439855 CDS YP_001746234.1 170681696 6142723 complement(4392100..4393557) 1 NC_010498.1 identified by match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR01427; putative PTS system transporter subunits IIBC 4393557 6142723 EcSMS35_4289 Escherichia coli SMS-3-5 putative PTS system transporter subunits IIBC YP_001746234.1 4392100 R 439855 CDS YP_001746235.1 170682227 6145882 complement(4393562..4394008) 1 NC_010498.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA 4394008 6145882 EcSMS35_4290 Escherichia coli SMS-3-5 putative fructose-like phosphotransferase system subunit EIIA YP_001746235.1 4393562 R 439855 CDS YP_001746236.1 170681010 6146426 4394485..4395879 1 NC_010498.1 identified by similarity to GB:AAB71432.1; glycoporin RafY 4395879 rafY2 6146426 rafY2 Escherichia coli SMS-3-5 glycoporin RafY YP_001746236.1 4394485 D 439855 CDS YP_001746237.1 170681510 6145191 complement(4395920..4396234) 1 NC_010498.1 identified by match to protein family HMM PF05336; match to protein family HMM TIGR02625; L-rhamnose 1-epimerase 4396234 rhaU 6145191 rhaU Escherichia coli SMS-3-5 L-rhamnose 1-epimerase YP_001746237.1 4395920 R 439855 CDS YP_001746238.1 170679635 6145695 complement(4396244..4397068) 1 NC_010498.1 identified by match to protein family HMM PF00596; match to protein family HMM TIGR02624; rhamnulose-1-phosphate aldolase 4397068 rhaD 6145695 rhaD Escherichia coli SMS-3-5 rhamnulose-1-phosphate aldolase YP_001746238.1 4396244 R 439855 CDS YP_001746239.1 170680183 6143792 complement(4397151..4398410) 1 NC_010498.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4398410 rhaA 6143792 rhaA Escherichia coli SMS-3-5 L-rhamnose isomerase YP_001746239.1 4397151 R 439855 CDS YP_001746240.1 170683095 6144349 complement(4398407..4399876) 1 NC_010498.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4399876 rhaB 6144349 rhaB Escherichia coli SMS-3-5 rhamnulokinase YP_001746240.1 4398407 R 439855 CDS YP_001746241.1 170682660 6147314 4399955..4400104 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4400104 6147314 EcSMS35_4296 Escherichia coli SMS-3-5 hypothetical protein YP_001746241.1 4399955 D 439855 CDS YP_001746242.1 170684163 6146867 4400164..4401000 1 NC_010498.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4401000 rhaS 6146867 rhaS Escherichia coli SMS-3-5 transcriptional activator RhaS YP_001746242.1 4400164 D 439855 CDS YP_001746243.1 170680171 6143463 4400984..4401922 1 NC_010498.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4401922 rhaR 6143463 rhaR Escherichia coli SMS-3-5 transcriptional activator RhaR YP_001746243.1 4400984 D 439855 CDS YP_001746244.1 170683644 6144337 complement(4401919..4402953) 1 NC_010498.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4402953 rhaT 6144337 rhaT Escherichia coli SMS-3-5 rhamnose-proton symporter YP_001746244.1 4401919 R 439855 CDS YP_001746245.1 170679702 6142936 4403238..4403858 1 NC_010498.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4403858 sodA 6142936 sodA Escherichia coli SMS-3-5 superoxide dismutase YP_001746245.1 4403238 D 439855 CDS YP_001746246.1 170682218 6143860 complement(4403887..4404015) 1 NC_010498.1 hypothetical protein 4404015 6143860 EcSMS35_4301 Escherichia coli SMS-3-5 hypothetical protein YP_001746246.1 4403887 R 439855 CDS YP_001746247.1 170682314 6146417 4404112..4405101 1 NC_010498.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4405101 kdgT 6146417 kdgT Escherichia coli SMS-3-5 2-keto-3-deoxygluconate permease YP_001746247.1 4404112 D 439855 CDS YP_001746248.1 170684189 6146513 4405250..4405924 1 NC_010498.1 identified by match to protein family HMM PF03473; match to protein family HMM PF03475; hypothetical protein 4405924 6146513 EcSMS35_4303 Escherichia coli SMS-3-5 hypothetical protein YP_001746248.1 4405250 D 439855 CDS YP_001746249.1 170683679 6143490 complement(4406029..4407402) 1 NC_010498.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4407402 cpxA 6143490 cpxA Escherichia coli SMS-3-5 two-component sensor protein YP_001746249.1 4406029 R 439855 CDS YP_001746250.1 170683339 6142971 complement(4407399..4408097) 1 NC_010498.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4408097 cpxR 6142971 cpxR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator CpxR YP_001746250.1 4407399 R 439855 CDS YP_001746251.1 170682865 6142624 4408244..4408747 1 NC_010498.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4408747 cpxP 6142624 cpxP Escherichia coli SMS-3-5 periplasmic repressor CpxP YP_001746251.1 4408244 D 439855 CDS YP_001746252.1 170680409 6147078 complement(4408933..4409913) 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 4409913 6147078 EcSMS35_4307 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001746252.1 4408933 R 439855 CDS YP_001746253.1 170679762 6144578 4410429..4410701 1 NC_010498.1 identified by similarity to SP:P07695; regulatory protein Cox 4410701 cox 6144578 cox Escherichia coli SMS-3-5 regulatory protein Cox YP_001746253.1 4410429 D 439855 CDS YP_001746254.1 170681421 6143921 4410704..4410874 1 NC_010498.1 identified by similarity to GB:AAP04469.1; hypothetical protein 4410874 6143921 EcSMS35_4309 Escherichia coli SMS-3-5 hypothetical protein YP_001746254.1 4410704 D 439855 CDS YP_001746255.1 170680717 6145605 4410880..4411371 1 NC_010498.1 putative replication gene B protein 4411371 6145605 EcSMS35_4310 Escherichia coli SMS-3-5 putative replication gene B protein YP_001746255.1 4410880 D 439855 CDS YP_001746256.1 170680443 6144892 4411435..4411659 1 NC_010498.1 hypothetical protein 4411659 6144892 EcSMS35_4311 Escherichia coli SMS-3-5 hypothetical protein YP_001746256.1 4411435 D 439855 CDS YP_001746257.1 170679798 6144612 4411659..4411961 1 NC_010498.1 hypothetical protein 4411961 6144612 EcSMS35_4312 Escherichia coli SMS-3-5 hypothetical protein YP_001746257.1 4411659 D 439855 CDS YP_001746258.1 170681432 6143958 4411961..4412185 1 NC_010498.1 identified by match to protein family HMM PF01258; match to protein family HMM TIGR02419; C4-type zinc finger DksA/TraR family protein 4412185 6143958 EcSMS35_4313 Escherichia coli SMS-3-5 C4-type zinc finger DksA/TraR family protein YP_001746258.1 4411961 D 439855 CDS YP_001746259.1 170680818 6145616 4412182..4412457 1 NC_010498.1 hypothetical protein 4412457 6145616 EcSMS35_4314 Escherichia coli SMS-3-5 hypothetical protein YP_001746259.1 4412182 D 439855 CDS YP_001746260.1 170681873 6144994 4412447..4414732 1 NC_010498.1 identified by similarity to SP:Q06419; match to protein family HMM PF05840; replication gene A protein 4414732 6144994 EcSMS35_4315 Escherichia coli SMS-3-5 replication gene A protein YP_001746260.1 4412447 D 439855 CDS YP_001746261.1 170681231 6146067 4414732..4415184 1 NC_010498.1 identified by similarity to GB:AAP04476.1; hypothetical protein 4415184 6146067 EcSMS35_4316 Escherichia coli SMS-3-5 hypothetical protein YP_001746261.1 4414732 D 439855 CDS YP_001746262.1 170679745 6145415 complement(4415256..4415378) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4415378 6145415 EcSMS35_4317 Escherichia coli SMS-3-5 hypothetical protein YP_001746262.1 4415256 R 439855 CDS YP_001746263.1 170680813 6143903 4415633..4416571 1 NC_010498.1 identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; DNA-cytosine methyltransferase family protein 4416571 6143903 EcSMS35_4319 Escherichia coli SMS-3-5 DNA-cytosine methyltransferase family protein YP_001746263.1 4415633 D 439855 CDS YP_001746264.1 170680417 6144989 complement(4416568..4417593) 1 NC_010498.1 identified by similarity to GB:AAN28261.1; hypothetical protein 4417593 6144989 EcSMS35_4318 Escherichia coli SMS-3-5 hypothetical protein YP_001746264.1 4416568 R 439855 CDS YP_001746265.1 170681446 6144586 complement(4417598..4418803) 1 NC_010498.1 identified by similarity to GB:AAN28262.1; hypothetical protein 4418803 6144586 EcSMS35_4320 Escherichia coli SMS-3-5 hypothetical protein YP_001746265.1 4417598 R 439855 CDS YP_001746266.1 170683028 6145631 4418887..4419048 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4419048 6145631 EcSMS35_4321 Escherichia coli SMS-3-5 hypothetical protein YP_001746266.1 4418887 D 439855 CDS YP_001746267.1 170683575 6147244 complement(4419087..4420121) 1 NC_010498.1 identified by match to protein family HMM PF04860; match to protein family HMM TIGR01540; PBSX family phage portal protein 4420121 6147244 EcSMS35_4322 Escherichia coli SMS-3-5 PBSX family phage portal protein YP_001746267.1 4419087 R 439855 CDS YP_001746268.1 170683976 6142866 complement(4420121..4421893) 1 NC_010498.1 identified by similarity to SP:P25479; match to protein family HMM PF03237; match to protein family HMM PF06056; phage large terminase subunit GpP 4421893 6142866 EcSMS35_4323 Escherichia coli SMS-3-5 phage large terminase subunit GpP YP_001746268.1 4420121 R 439855 CDS YP_001746269.1 170679886 6143273 4422067..4422921 1 NC_010498.1 identified by match to protein family HMM PF05929; phage capsid scaffolding protein GpO 4422921 6143273 EcSMS35_4324 Escherichia coli SMS-3-5 phage capsid scaffolding protein GpO YP_001746269.1 4422067 D 439855 CDS YP_001746270.1 170680464 6144048 4422980..4424053 1 NC_010498.1 identified by match to protein family HMM PF05125; match to protein family HMM TIGR01551; phage major capsid protein GpN 4424053 6144048 EcSMS35_4325 Escherichia coli SMS-3-5 phage major capsid protein GpN YP_001746270.1 4422980 D 439855 CDS YP_001746271.1 170679972 6144633 4424057..4424800 1 NC_010498.1 identified by similarity to SP:P25476; match to protein family HMM PF05944; phage small terminase subunit GpM 4424800 6144633 EcSMS35_4326 Escherichia coli SMS-3-5 phage small terminase subunit GpM YP_001746271.1 4424057 D 439855 CDS YP_001746272.1 170684000 6144134 4424900..4425409 1 NC_010498.1 identified by similarity to SP:P25475; match to protein family HMM PF05926; phage head completion protein GPL 4425409 6144134 EcSMS35_4327 Escherichia coli SMS-3-5 phage head completion protein GPL YP_001746272.1 4424900 D 439855 CDS YP_001746273.1 170683553 6143299 4425409..4425612 1 NC_010498.1 identified by similarity to SP:P51772; match to protein family HMM PF05489; phage tail protein GpX 4425612 6143299 EcSMS35_4328 Escherichia coli SMS-3-5 phage tail protein GpX YP_001746273.1 4425409 D 439855 CDS YP_001746274.1 170679755 6142843 4425616..4425897 1 NC_010498.1 identified by similarity to SP:P51773; match to protein family HMM PF04550; phage holin GpY 4425897 6142843 EcSMS35_4329 Escherichia coli SMS-3-5 phage holin GpY YP_001746274.1 4425616 D 439855 CDS YP_001746275.1 170681609 6143913 4425897..4426394 1 NC_010498.1 identified by match to protein family HMM PF00959; phage lysozyme 4426394 6143913 EcSMS35_4330 Escherichia coli SMS-3-5 phage lysozyme YP_001746275.1 4425897 D 439855 CDS YP_001746276.1 170680810 6145794 4426409..4426834 1 NC_010498.1 identified by similarity to SP:P51769; phage lysis protein LysA 4426834 6145794 EcSMS35_4331 Escherichia coli SMS-3-5 phage lysis protein LysA YP_001746276.1 4426409 D 439855 CDS YP_001746277.1 170682622 6144986 4426822..4427247 1 NC_010498.1 identified by similarity to SP:P51770; phage lysis timing protein LysB 4427247 6144986 EcSMS35_4332 Escherichia coli SMS-3-5 phage lysis timing protein LysB YP_001746277.1 4426822 D 439855 CDS YP_001746278.1 170682508 6146828 4427102..4427392 1 NC_010498.1 identified by similarity to GB:AAM83596.1; phage lysis protein LysC 4427392 6146828 EcSMS35_4333 Escherichia coli SMS-3-5 phage lysis protein LysC YP_001746278.1 4427102 D 439855 CDS YP_001746279.1 170684060 6146708 4427355..4427822 1 NC_010498.1 identified by match to protein family HMM PF06891; phage tail completion protein GpR 4427822 6146708 EcSMS35_4334 Escherichia coli SMS-3-5 phage tail completion protein GpR YP_001746279.1 4427355 D 439855 CDS YP_001746280.1 170681856 6143359 4427815..4428267 1 NC_010498.1 identified by match to protein family HMM PF05069; match to protein family HMM TIGR01635; phage virion morphogenesis protein GpS 4428267 6143359 EcSMS35_4335 Escherichia coli SMS-3-5 phage virion morphogenesis protein GpS YP_001746280.1 4427815 D 439855 CDS YP_001746281.1 170681352 6146050 complement(4428339..4429124) 1 NC_010498.1 identified by similarity to SP:P36935; hypothetical protein 4429124 6146050 EcSMS35_4336 Escherichia coli SMS-3-5 hypothetical protein YP_001746281.1 4428339 R 439855 CDS YP_001746282.1 170680863 6145536 4429208..4429843 1 NC_010498.1 identified by similarity to SP:P31340; match to protein family HMM PF04717; match to protein family HMM TIGR01644; phage baseplate assembly protein GpV 4429843 6145536 EcSMS35_4337 Escherichia coli SMS-3-5 phage baseplate assembly protein GpV YP_001746282.1 4429208 D 439855 CDS YP_001746283.1 170682747 6145040 4429840..4430187 1 NC_010498.1 identified by similarity to SP:P51768; match to protein family HMM PF04965; baseplate assembly protein GPW 4430187 6145040 EcSMS35_4338 Escherichia coli SMS-3-5 baseplate assembly protein GPW YP_001746283.1 4429840 D 439855 CDS YP_001746284.1 170682153 6146955 4430192..4431100 1 NC_010498.1 identified by match to protein family HMM PF04865; baseplate assembly protein GpJ 4431100 6146955 EcSMS35_4339 Escherichia coli SMS-3-5 baseplate assembly protein GpJ YP_001746284.1 4430192 D 439855 CDS YP_001746285.1 170684063 6146352 4431093..4431623 1 NC_010498.1 identified by match to protein family HMM TIGR01634; phage tail protein GpI 4431623 6146352 EcSMS35_4340 Escherichia coli SMS-3-5 phage tail protein GpI YP_001746285.1 4431093 D 439855 CDS YP_001746286.1 170683508 6143363 4431634..4433655 1 NC_010498.1 identified by match to protein family HMM PF03406; putative phage tail fiber protein 4433655 6143363 EcSMS35_4341 Escherichia coli SMS-3-5 putative phage tail fiber protein YP_001746286.1 4431634 D 439855 CDS YP_001746287.1 170680642 6142797 4433657..4434184 1 NC_010498.1 identified by similarity to SP:P26699; match to protein family HMM PF02413; tail fiber assembly protein GpG 4434184 6142797 EcSMS35_4342 Escherichia coli SMS-3-5 tail fiber assembly protein GpG YP_001746287.1 4433657 D 439855 CDS YP_001746288.1 170680135 6144817 4434400..4435299 1 NC_010498.1 identified by similarity to GB:ABM26356.1; hypothetical protein 4435299 6144817 EcSMS35_4343 Escherichia coli SMS-3-5 hypothetical protein YP_001746288.1 4434400 D 439855 CDS YP_001746289.1 170679607 6144301 complement(4435462..4435599) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4435599 6144301 EcSMS35_4344 Escherichia coli SMS-3-5 hypothetical protein YP_001746289.1 4435462 R 439855 CDS YP_001746290.1 170683123 6143764 4435619..4436809 1 NC_010498.1 identified by match to protein family HMM PF04984; phage tail sheath protein 4436809 6143764 EcSMS35_4345 Escherichia coli SMS-3-5 phage tail sheath protein YP_001746290.1 4435619 D 439855 CDS YP_001746291.1 170679796 6147342 4436822..4437340 1 NC_010498.1 identified by match to protein family HMM PF04985; match to protein family HMM TIGR01611; phage major tail tube protein FII 4437340 6147342 EcSMS35_4346 Escherichia coli SMS-3-5 phage major tail tube protein FII YP_001746291.1 4436822 D 439855 CDS YP_001746292.1 170680568 6143956 4437397..4437672 1 NC_010498.1 identified by match to protein family HMM PF06158; phage tail protein E 4437672 6143956 EcSMS35_4347 Escherichia coli SMS-3-5 phage tail protein E YP_001746292.1 4437397 D 439855 CDS YP_001746293.1 170683330 6144738 4437705..4437824 1 NC_010498.1 identified by match to protein family HMM PF06528; phage tail protein P2 4437824 6144738 EcSMS35_4348 Escherichia coli SMS-3-5 phage tail protein P2 YP_001746293.1 4437705 D 439855 CDS YP_001746294.1 170683855 6142615 4437817..4440264 1 NC_010498.1 identified by match to protein family HMM TIGR01760; TP901 family phage tail tape measure protein 4440264 6142615 EcSMS35_4349 Escherichia coli SMS-3-5 TP901 family phage tail tape measure protein YP_001746294.1 4437817 D 439855 CDS YP_001746295.1 170684272 6143149 4440279..4440758 1 NC_010498.1 identified by match to protein family HMM PF06995; phage protein gpU 4440758 gpU 6143149 gpU Escherichia coli SMS-3-5 phage protein gpU YP_001746295.1 4440279 D 439855 CDS YP_001746296.1 170682551 6143574 4440758..4441921 1 NC_010498.1 identified by match to protein family HMM PF05954; phage late control gene D protein 4441921 6143574 EcSMS35_4351 Escherichia coli SMS-3-5 phage late control gene D protein YP_001746296.1 4440758 D 439855 CDS YP_001746297.1 170680871 6146753 4442003..4442221 1 NC_010498.1 in E. coli K-12 this is in prophage P2 remnant; DNA-binding transcriptional regulator 4442221 6146753 EcSMS35_4352 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator YP_001746297.1 4442003 D 439855 CDS YP_001746298.1 170681391 6145049 complement(4442260..4443588) 1 NC_010498.1 identified by match to protein family HMM PF01609; IS4 transposase 4443588 6145049 EcSMS35_4353 Escherichia coli SMS-3-5 IS4 transposase YP_001746298.1 4442260 R 439855 CDS YP_001746299.1 170681519 6145575 4443760..4443882 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4443882 6145575 EcSMS35_4354 Escherichia coli SMS-3-5 hypothetical protein YP_001746299.1 4443760 D 439855 CDS YP_001746300.1 170680343 6145704 4443897..4444799 1 NC_010498.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4444799 fieF 6145704 fieF Escherichia coli SMS-3-5 ferrous iron efflux protein F YP_001746300.1 4443897 D 439855 CDS YP_001746301.1 170680873 6144511 4444980..4445942 1 NC_010498.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4445942 pfkA 6144511 pfkA Escherichia coli SMS-3-5 6-phosphofructokinase YP_001746301.1 4444980 D 439855 CDS YP_001746302.1 170681821 6145051 4446262..4447251 1 NC_010498.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971; sulfate transporter subunit 4447251 sbp 6145051 sbp Escherichia coli SMS-3-5 sulfate transporter subunit YP_001746302.1 4446262 D 439855 CDS YP_001746303.1 170679863 6146014 4447358..4448113 1 NC_010498.1 identified by match to protein family HMM PF02611; match to protein family HMM TIGR00672; CDP-diacylglycerol pyrophosphatase 4448113 cdh 6146014 cdh Escherichia coli SMS-3-5 CDP-diacylglycerol pyrophosphatase YP_001746303.1 4447358 D 439855 CDS YP_001746304.1 170680397 6144025 complement(4448168..4448935) 1 NC_010498.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4448935 tpiA 6144025 tpiA Escherichia coli SMS-3-5 triosephosphate isomerase YP_001746304.1 4448168 R 439855 CDS YP_001746305.1 170683452 6144566 complement(4449043..4449642) 1 NC_010498.1 identified by match to protein family HMM PF07305; hypothetical protein 4449642 6144566 EcSMS35_4360 Escherichia coli SMS-3-5 hypothetical protein YP_001746305.1 4449043 R 439855 CDS YP_001746306.1 170683358 6142739 4449743..4450183 1 NC_010498.1 identified by match to protein family HMM PF05656; hypothetical protein 4450183 6142739 EcSMS35_4361 Escherichia coli SMS-3-5 hypothetical protein YP_001746306.1 4449743 D 439855 CDS YP_001746307.1 170682392 6142644 4450395..4450694 1 NC_010498.1 identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743; hypothetical protein 4450694 6142644 EcSMS35_4362 Escherichia coli SMS-3-5 hypothetical protein YP_001746307.1 4450395 D 439855 CDS YP_001746308.1 170683094 6146591 4450721..4451149 1 NC_010498.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4451149 uspD 6146591 uspD Escherichia coli SMS-3-5 universal stress protein UspD YP_001746308.1 4450721 D 439855 CDS YP_001746309.1 170683111 6147312 complement(4451154..4451900) 1 NC_010498.1 identified by match to protein family HMM PF00175; match to protein family HMM PF00970; ferredoxin-NADP reductase 4451900 fpr 6147312 fpr Escherichia coli SMS-3-5 ferredoxin-NADP reductase YP_001746309.1 4451154 R 439855 CDS YP_001746310.1 170681842 6147330 complement(4451997..4453007) 1 NC_010498.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4453007 glpX 6147330 glpX Escherichia coli SMS-3-5 fructose 1,6-bisphosphatase II YP_001746310.1 4451997 R 439855 CDS YP_001746311.1 170680579 6146035 complement(4453142..4454650) 1 NC_010498.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4454650 glpK 6146035 glpK Escherichia coli SMS-3-5 glycerol kinase YP_001746311.1 4453142 R 439855 CDS YP_001746312.1 170681277 6144749 complement(4454673..4455518) 1 NC_010498.1 identified by similarity to SP:P0AER0; match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein 4455518 glpF 6144749 glpF Escherichia coli SMS-3-5 glycerol uptake facilitator protein YP_001746312.1 4454673 R 439855 CDS YP_001746313.1 170683843 6145461 4455943..4456188 1 NC_010498.1 identified by match to protein family HMM PF06005; hypothetical protein 4456188 6145461 EcSMS35_4368 Escherichia coli SMS-3-5 hypothetical protein YP_001746313.1 4455943 D 439855 CDS YP_001746314.1 170679773 6143137 complement(4456227..4456943) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4456943 6143137 EcSMS35_4369 Escherichia coli SMS-3-5 hypothetical protein YP_001746314.1 4456227 R 439855 CDS YP_001746315.1 170682658 6143932 complement(4456976..4457650) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4457650 6143932 EcSMS35_4370 Escherichia coli SMS-3-5 hypothetical protein YP_001746315.1 4456976 R 439855 CDS YP_001746316.1 170684101 6146865 complement(4457710..4458195) 1 NC_010498.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4458195 rraA 6146865 rraA Escherichia coli SMS-3-5 ribonuclease activity regulator protein RraA YP_001746316.1 4457710 R 439855 CDS YP_001746317.1 170682345 6143401 complement(4458288..4459226) 1 NC_010498.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4459226 menA 6143401 menA Escherichia coli SMS-3-5 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_001746317.1 4458288 R 439855 CDS YP_001746318.1 170683012 6146544 complement(4459281..4460612) 1 NC_010498.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4460612 hslU 6146544 hslU Escherichia coli SMS-3-5 ATP-dependent protease ATP-binding subunit HslU YP_001746318.1 4459281 R 439855 CDS YP_001746319.1 170680847 6147228 complement(4460622..4461152) 1 NC_010498.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4461152 hslV 6147228 hslV Escherichia coli SMS-3-5 ATP-dependent protease peptidase subunit YP_001746319.1 4460622 R 439855 CDS YP_001746320.1 170683167 6145024 complement(4461245..4462204) 1 NC_010498.1 identified by match to protein family HMM PF05036; match to protein family HMM TIGR02223; essential cell division protein FtsN 4462204 ftsN 6145024 ftsN Escherichia coli SMS-3-5 essential cell division protein FtsN YP_001746320.1 4461245 R 439855 CDS YP_001746321.1 170681439 6147387 complement(4462296..4463321) 1 NC_010498.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4463321 cytR 6147387 cytR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator CytR YP_001746321.1 4462296 R 439855 CDS YP_001746322.1 170681937 6145623 complement(4463477..4465675) 1 NC_010498.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4465675 priA 6145623 priA Escherichia coli SMS-3-5 primosome assembly protein PriA YP_001746322.1 4463477 R 439855 CDS YP_001746323.1 170680515 6146133 4465878..4466090 1 NC_010498.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4466090 rpmE 6146133 rpmE Escherichia coli SMS-3-5 50S ribosomal protein L31 YP_001746323.1 4465878 D 439855 CDS YP_001746324.1 170681030 6144685 complement(4466151..4466759) 1 NC_010498.1 member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase 4466759 6144685 EcSMS35_4379 Escherichia coli SMS-3-5 putative peptidoglycan peptidase YP_001746324.1 4466151 R 439855 CDS YP_001746325.1 170684185 6145211 complement(4466819..4467136) 1 NC_010498.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4467136 metJ 6145211 metJ Escherichia coli SMS-3-5 transcriptional repressor protein MetJ YP_001746325.1 4466819 R 439855 CDS YP_001746326.1 170679867 6143486 4467413..4468573 1 NC_010498.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4468573 metB 6143486 metB Escherichia coli SMS-3-5 cystathionine gamma-synthase YP_001746326.1 4467413 D 439855 CDS YP_001746327.1 170683157 6144029 4468576..4471008 1 NC_010498.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4471008 metL 6144029 metL Escherichia coli SMS-3-5 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_001746327.1 4468576 D 439855 CDS YP_001746328.1 170683669 6147377 4471015..4471158 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4471158 6147377 EcSMS35_4383 Escherichia coli SMS-3-5 hypothetical protein YP_001746328.1 4471015 D 439855 CDS YP_001746329.1 170682215 6142961 complement(4471225..4472085) 1 NC_010498.1 identified by similarity to SP:P40786; match to protein family HMM PF03502; nucleoside-specific channel-forming protein Tsx 4472085 tsx2 6142961 tsx2 Escherichia coli SMS-3-5 nucleoside-specific channel-forming protein Tsx YP_001746329.1 4471225 R 439855 CDS YP_001746330.1 170683900 6146414 complement(4472163..4473782) 1 NC_010498.1 identified by match to protein family HMM PF00149; match to protein family HMM PF02872; serine/threonine protein phosphatase family protein 4473782 6146414 EcSMS35_4385 Escherichia coli SMS-3-5 serine/threonine protein phosphatase family protein YP_001746330.1 4472163 R 439855 CDS YP_001746331.1 170680658 6143196 complement(4473823..4475373) 1 NC_010498.1 identified by match to protein family HMM PF00149; match to protein family HMM PF02872; serine/threonine protein phosphatase family protein 4475373 6143196 EcSMS35_4386 Escherichia coli SMS-3-5 serine/threonine protein phosphatase family protein YP_001746331.1 4473823 R 439855 CDS YP_001746332.1 170683638 6144833 complement(4475606..4476733) 1 NC_010498.1 identified by similarity to GB:CAD09521.1; hypothetical protein 4476733 6144833 EcSMS35_4387 Escherichia coli SMS-3-5 hypothetical protein YP_001746332.1 4475606 R 439855 CDS YP_001746333.1 170681676 6142929 4476866..4478419 1 NC_010498.1 identified by match to protein family HMM PF00149; match to protein family HMM PF02872; serine/threonine protein phosphatase family protein 4478419 6142929 EcSMS35_4388 Escherichia coli SMS-3-5 serine/threonine protein phosphatase family protein YP_001746333.1 4476866 D 439855 CDS YP_001746334.1 170680126 6145862 4478801..4479691 1 NC_010498.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4479691 metF 6145862 metF Escherichia coli SMS-3-5 5,10-methylenetetrahydrofolate reductase YP_001746334.1 4478801 D 439855 CDS YP_001746335.1 170682728 6144291 4480020..4482200 1 NC_010498.1 identified by match to protein family HMM PF00141; match to protein family HMM TIGR00198; catalase/peroxidase HPI 4482200 katG 6144291 katG Escherichia coli SMS-3-5 catalase/peroxidase HPI YP_001746335.1 4480020 D 439855 CDS YP_001746336.1 170681167 6146936 4482294..4483199 1 NC_010498.1 identified by match to protein family HMM PF00892; putative transporter 4483199 6146936 EcSMS35_4391 Escherichia coli SMS-3-5 putative transporter YP_001746336.1 4482294 D 439855 CDS YP_001746337.1 170683775 6145351 complement(4483224..4483841) 1 NC_010498.1 identified by match to protein family HMM PF06940; hypothetical protein 4483841 6145351 EcSMS35_4392 Escherichia coli SMS-3-5 hypothetical protein YP_001746337.1 4483224 R 439855 CDS YP_001746338.1 170682139 6143067 complement(4484116..4485219) 1 NC_010498.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4485219 gldA 6143067 gldA Escherichia coli SMS-3-5 glycerol dehydrogenase YP_001746338.1 4484116 R 439855 CDS YP_001746339.1 170680048 6146338 complement(4485230..4485892) 1 NC_010498.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4485892 fsaB 6146338 fsaB Escherichia coli SMS-3-5 fructose-6-phosphate aldolase YP_001746339.1 4485230 R 439855 CDS YP_001746340.1 170679892 6144211 complement(4485904..4488405) 1 NC_010498.1 identified by match to protein family HMM PF00359; match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; multi-phosphoryl transfer protein 2 4488405 ptsA 6144211 ptsA Escherichia coli SMS-3-5 multi-phosphoryl transfer protein 2 YP_001746340.1 4485904 R 439855 CDS YP_001746341.1 170681906 6144054 4488714..4489793 1 NC_010498.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4489793 6144054 EcSMS35_4396 Escherichia coli SMS-3-5 putative fructose-like permease EIIC subunit 2 YP_001746341.1 4488714 D 439855 CDS YP_001746342.1 170681246 6146101 4489808..4490128 1 NC_010498.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4490128 6146101 EcSMS35_4397 Escherichia coli SMS-3-5 putative PTS system fructose-like transporter subunit EIIB YP_001746342.1 4489808 D 439855 CDS YP_001746343.1 170680527 6145430 4490179..4492476 1 NC_010498.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4492476 pflD 6145430 pflD Escherichia coli SMS-3-5 putative formate acetyltransferase 2 YP_001746343.1 4490179 D 439855 CDS YP_001746344.1 170680362 6144697 4492442..4493320 1 NC_010498.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate lyase II activase 4493320 6144697 EcSMS35_4399 Escherichia coli SMS-3-5 pyruvate formate lyase II activase YP_001746344.1 4492442 D 439855 CDS YP_001746345.1 170683773 6144530 4493322..4493663 1 NC_010498.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4493663 6144530 EcSMS35_4401 Escherichia coli SMS-3-5 putative fructose-like phosphotransferase EIIB subunit 3 YP_001746345.1 4493322 D 439855 CDS YP_001746346.1 170682151 6143065 complement(4493650..4494501) 1 NC_010498.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 4494501 6143065 EcSMS35_4400 Escherichia coli SMS-3-5 AraC family transcriptional regulator YP_001746346.1 4493650 R 439855 CDS YP_001746347.1 170680859 6146350 complement(4494650..4496383) 1 NC_010498.1 identified by match to protein family HMM PF00884; hypothetical protein 4496383 6146350 EcSMS35_4402 Escherichia coli SMS-3-5 hypothetical protein YP_001746347.1 4494650 R 439855 CDS YP_001746348.1 170683041 6145036 complement(4496566..4499217) 1 NC_010498.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4499217 ppc 6145036 ppc Escherichia coli SMS-3-5 phosphoenolpyruvate carboxylase YP_001746348.1 4496566 R 439855 CDS YP_001746349.1 170680148 6147257 complement(4499519..4500670) 1 NC_010498.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4500670 argE 6147257 argE Escherichia coli SMS-3-5 acetylornithine deacetylase YP_001746349.1 4499519 R 439855 CDS YP_001746350.1 170681939 6144314 4500824..4501828 1 NC_010498.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4501828 argC 6144314 argC Escherichia coli SMS-3-5 N-acetyl-gamma-glutamyl-phosphate reductase YP_001746350.1 4500824 D 439855 CDS YP_001746351.1 170679580 6146135 4501839..4502612 1 NC_010498.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4502612 argB 6146135 argB Escherichia coli SMS-3-5 acetylglutamate kinase YP_001746351.1 4501839 D 439855 CDS YP_001746352.1 170680227 6143737 4502673..4504046 1 NC_010498.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4504046 argH 6143737 argH Escherichia coli SMS-3-5 argininosuccinate lyase YP_001746352.1 4502673 D 439855 CDS YP_001746353.1 170679918 6144393 4504313..4505230 1 NC_010498.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4505230 oxyR 6144393 oxyR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator OxyR YP_001746353.1 4504313 D 439855 CDS YP_001746354.1 170681015 6144080 complement(4505213..4506613) 1 NC_010498.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4506613 sthA 6144080 sthA Escherichia coli SMS-3-5 soluble pyridine nucleotide transhydrogenase YP_001746354.1 4505213 R 439855 CDS YP_001746355.1 170681137 6145196 4506891..4507595 1 NC_010498.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4507595 fabR 6145196 fabR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor FabR YP_001746355.1 4506891 D 439855 CDS YP_001746356.1 170681797 6145320 4507595..4507954 1 NC_010498.1 identified by match to protein family HMM PF07226; hypothetical protein 4507954 6145320 EcSMS35_4411 Escherichia coli SMS-3-5 hypothetical protein YP_001746356.1 4507595 D 439855 CDS YP_001746357.1 170681986 6145990 complement(4507994..4509094) 1 NC_010498.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4509094 trmA 6145990 trmA Escherichia coli SMS-3-5 tRNA (uracil-5-)-methyltransferase YP_001746357.1 4507994 R 439855 CDS YP_001746358.1 170682641 6146182 4509463..4511307 1 NC_010498.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4511307 btuB 6146182 btuB Escherichia coli SMS-3-5 vitamin B12/cobalamin outer membrane transporter YP_001746358.1 4509463 D 439855 CDS YP_001746359.1 170680254 6146847 4511321..4512109 1 NC_010498.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4512109 murI 6146847 murI Escherichia coli SMS-3-5 glutamate racemase YP_001746359.1 4511321 D 439855 CDS YP_001746360.1 170684112 6143730 4517629..4518657 1 NC_010498.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4518657 murB 6143730 murB Escherichia coli SMS-3-5 UDP-N-acetylenolpyruvoylglucosamine reductase YP_001746360.1 4517629 D 439855 CDS YP_001746361.1 170682429 6143412 4518654..4519619 1 NC_010498.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4519619 birA 6143412 birA Escherichia coli SMS-3-5 biotin--protein ligase YP_001746361.1 4518654 D 439855 CDS YP_001746362.1 170680730 6146628 complement(4519648..4520598) 1 NC_010498.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4520598 coaA 6146628 coaA Escherichia coli SMS-3-5 pantothenate kinase YP_001746362.1 4519648 R 439855 CDS YP_001746363.1 170680216 6144905 4520581..4520775 1 NC_010498.1 identified by similarity to GB:BAC18512.1; hypothetical protein 4520775 6144905 EcSMS35_4423 Escherichia coli SMS-3-5 hypothetical protein YP_001746363.1 4520581 D 439855 CDS YP_001746364.1 170681349 6143658 4521516..4522700 1 NC_010498.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4522700 tuf1 6143658 tuf1 Escherichia coli SMS-3-5 elongation factor Tu YP_001746364.1 4521516 D 439855 CDS YP_001746365.1 170679747 6145533 4522930..4523313 1 NC_010498.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4523313 secE 6145533 secE Escherichia coli SMS-3-5 preprotein translocase subunit SecE YP_001746365.1 4522930 D 439855 CDS YP_001746366.1 170682823 6143905 4523315..4523860 1 NC_010498.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4523860 nusG 6143905 nusG Escherichia coli SMS-3-5 transcription antitermination protein NusG YP_001746366.1 4523315 D 439855 CDS YP_001746367.1 170681035 6147034 4524019..4524447 1 NC_010498.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4524447 rplK 6147034 rplK Escherichia coli SMS-3-5 50S ribosomal protein L11 YP_001746367.1 4524019 D 439855 CDS YP_001746368.1 170682240 6145216 4524451..4525155 1 NC_010498.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4525155 rplA 6145216 rplA Escherichia coli SMS-3-5 50S ribosomal protein L1 YP_001746368.1 4524451 D 439855 CDS YP_001746369.1 170683724 6146439 4525447..4525944 1 NC_010498.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4525944 rplJ 6146439 rplJ Escherichia coli SMS-3-5 50S ribosomal protein L10 YP_001746369.1 4525447 D 439855 CDS YP_001746370.1 170681674 6143016 4526011..4526376 1 NC_010498.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4526376 rplL 6143016 rplL Escherichia coli SMS-3-5 50S ribosomal protein L7/L12 YP_001746370.1 4526011 D 439855 CDS YP_001746371.1 170680149 6145860 4526696..4530724 1 NC_010498.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4530724 rpoB 6145860 rpoB Escherichia coli SMS-3-5 DNA-directed RNA polymerase subunit beta YP_001746371.1 4526696 D 439855 CDS YP_001746372.1 170682674 6144315 4530801..4535024 1 NC_010498.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4535024 rpoC 6144315 rpoC Escherichia coli SMS-3-5 DNA-directed RNA polymerase subunit beta' YP_001746372.1 4530801 D 439855 CDS YP_001746373.1 170681122 6146882 complement(4535266..4536399) 1 NC_010498.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4536399 thiH 6146882 thiH Escherichia coli SMS-3-5 thiamine biosynthesis protein ThiH YP_001746373.1 4535266 R 439855 CDS YP_001746374.1 170683844 6145305 complement(4536396..4537211) 1 NC_010498.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4537211 thiG 6145305 thiG Escherichia coli SMS-3-5 thiazole synthase YP_001746374.1 4536396 R 439855 CDS YP_001746375.1 170682128 6143138 complement(4537168..4537368) 1 NC_010498.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4537368 thiS 6143138 thiS Escherichia coli SMS-3-5 sulfur carrier protein ThiS YP_001746375.1 4537168 R 439855 CDS YP_001746376.1 170680052 6146327 complement(4537352..4538107) 1 NC_010498.1 identified by match to protein family HMM PF00899; match to protein family HMM PF05237; match to protein family HMM TIGR02356; thiazole biosynthesis adenylyltransferase ThiF 4538107 thiF 6146327 thiF Escherichia coli SMS-3-5 thiazole biosynthesis adenylyltransferase ThiF YP_001746376.1 4537352 R 439855 CDS YP_001746377.1 170680715 6144216 complement(4538100..4538735) 1 NC_010498.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4538735 thiE 6144216 thiE Escherichia coli SMS-3-5 thiamine-phosphate pyrophosphorylase YP_001746377.1 4538100 R 439855 CDS YP_001746378.1 170680038 6144890 complement(4538735..4540630) 1 NC_010498.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4540630 thiC 6144890 thiC Escherichia coli SMS-3-5 thiamine biosynthesis protein ThiC YP_001746378.1 4538735 R 439855 CDS YP_001746379.1 170681786 6144201 complement(4540863..4541339) 1 NC_010498.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4541339 rsd 6144201 rsd Escherichia coli SMS-3-5 anti-RNA polymerase sigma 70 factor YP_001746379.1 4540863 R 439855 CDS YP_001746380.1 170680713 6145978 4541434..4542207 1 NC_010498.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4542207 nudC 6145978 nudC Escherichia coli SMS-3-5 NADH pyrophosphatase YP_001746380.1 4541434 D 439855 CDS YP_001746381.1 170683454 6144888 4542247..4543311 1 NC_010498.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4543311 hemE 6144888 hemE Escherichia coli SMS-3-5 uroporphyrinogen decarboxylase YP_001746381.1 4542247 D 439855 CDS YP_001746382.1 170681451 6142741 4543321..4543992 1 NC_010498.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4543992 nfi 6142741 nfi Escherichia coli SMS-3-5 endonuclease V YP_001746382.1 4543321 D 439855 CDS YP_001746383.1 170680037 6145636 4544035..4544625 1 NC_010498.1 identified by match to protein family HMM PF04222; hypothetical protein 4544625 6145636 EcSMS35_4447 Escherichia coli SMS-3-5 hypothetical protein YP_001746383.1 4544035 D 439855 CDS YP_001746384.1 170682013 6144200 4544812..4545084 1 NC_010498.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4545084 hupA 6144200 hupA Escherichia coli SMS-3-5 transcriptional regulator HU subunit alpha YP_001746384.1 4544812 D 439855 CDS YP_001746385.1 170682529 6146210 4545157..4545792 1 NC_010498.1 identified by match to protein family HMM PF07356; hypothetical protein 4545792 6146210 EcSMS35_4449 Escherichia coli SMS-3-5 hypothetical protein YP_001746385.1 4545157 D 439855 CDS YP_001746386.1 170684083 6146730 complement(4545794..4546213) 1 NC_010498.1 zinc resistance protein 4546213 zraP 6146730 zraP Escherichia coli SMS-3-5 zinc resistance protein YP_001746386.1 4545794 R 439855 CDS YP_001746387.1 170683879 6143383 complement(4546216..4546344) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4546344 6143383 EcSMS35_4451 Escherichia coli SMS-3-5 hypothetical protein YP_001746387.1 4546216 R 439855 CDS YP_001746388.1 170683574 6143174 4546451..4547827 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein ZraS 4547827 zraS 6143174 zraS Escherichia coli SMS-3-5 sensor protein ZraS YP_001746388.1 4546451 D 439855 CDS YP_001746389.1 170680150 6142865 4547824..4549149 1 NC_010498.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4549149 zraR 6142865 zraR Escherichia coli SMS-3-5 transcriptional regulatory protein ZraR YP_001746389.1 4547824 D 439855 CDS YP_001746390.1 170683731 6144316 complement(4549146..4550435) 1 NC_010498.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4550435 purD 6144316 purD Escherichia coli SMS-3-5 phosphoribosylamine--glycine ligase YP_001746390.1 4549146 R 439855 CDS YP_001746391.1 170680627 6143023 complement(4550447..4552036) 1 NC_010498.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4552036 purH 6143023 purH Escherichia coli SMS-3-5 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001746391.1 4550447 R 439855 CDS YP_001746392.1 170681671 6144802 4552154..4552276 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4552276 6144802 EcSMS35_4456 Escherichia coli SMS-3-5 hypothetical protein YP_001746392.1 4552154 D 439855 CDS YP_001746393.1 170683727 6145341 4558033..4558344 1 NC_010498.1 identified by match to protein family HMM PF01527; IS3 family transposase orfA 4558344 6145341 EcSMS35_4464 Escherichia coli SMS-3-5 IS3 family transposase orfA YP_001746393.1 4558033 D 439855 CDS YP_001746394.1 170682021 6143019 4558464..4559210 1 NC_010498.1 identified by match to protein family HMM PF00665; IS3 family transposase orfB 4559210 6143019 EcSMS35_4465 Escherichia coli SMS-3-5 IS3 family transposase orfB YP_001746394.1 4558464 D 439855 CDS YP_001746395.1 170681732 6144772 4559649..4560578 1 NC_010498.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4560578 metA 6144772 metA Escherichia coli SMS-3-5 homoserine O-succinyltransferase YP_001746395.1 4559649 D 439855 CDS YP_001746396.1 170683352 6145921 4560847..4562448 1 NC_010498.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4562448 aceB 6145921 aceB Escherichia coli SMS-3-5 malate synthase YP_001746396.1 4560847 D 439855 CDS YP_001746397.1 170682682 6142638 4562478..4563782 1 NC_010498.1 identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346; isocitrate lyase 4563782 aceA 6142638 aceA Escherichia coli SMS-3-5 isocitrate lyase YP_001746397.1 4562478 D 439855 CDS YP_001746398.1 170679928 6146890 4563966..4565690 1 NC_010498.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4565690 aceK 6146890 aceK Escherichia coli SMS-3-5 bifunctional isocitrate dehydrogenase kinase/phosphatase protein YP_001746398.1 4563966 D 439855 CDS YP_001746399.1 170683355 6144090 complement(4565707..4566531) 1 NC_010498.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR 4566531 iclR 6144090 iclR Escherichia coli SMS-3-5 transcriptional repressor IclR YP_001746399.1 4565707 R 439855 CDS YP_001746400.1 170681236 6142641 4566731..4570414 1 NC_010498.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4570414 metH 6142641 metH Escherichia coli SMS-3-5 B12-dependent methionine synthase YP_001746400.1 4566731 D 439855 CDS YP_001746401.1 170680550 6145420 4570634..4572265 1 NC_010498.1 identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; match to protein family HMM TIGR01013; inorganic phosphate transporter, sodium-dependent 4572265 pNaS 6145420 pNaS Escherichia coli SMS-3-5 inorganic phosphate transporter, sodium-dependent YP_001746401.1 4570634 D 439855 CDS YP_001746402.1 170681887 6144720 complement(4572355..4573044) 1 NC_010498.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4573044 pepE 6144720 pepE Escherichia coli SMS-3-5 peptidase E YP_001746402.1 4572355 R 439855 CDS YP_001746403.1 170681241 6146081 complement(4573167..4573979) 1 NC_010498.1 catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 4573979 6146081 EcSMS35_4475 Escherichia coli SMS-3-5 shikimate 5-dehydrogenase YP_001746403.1 4573167 R 439855 CDS YP_001746404.1 170682637 6145425 complement(4573972..4575201) 1 NC_010498.1 identified by similarity to SP:P37084; match to protein family HMM PF00107; match to protein family HMM PF08240; L-sorbose 1-phosphate reductase 4575201 6145425 EcSMS35_4476 Escherichia coli SMS-3-5 L-sorbose 1-phosphate reductase YP_001746404.1 4573972 R 439855 CDS YP_001746405.1 170683591 6146843 complement(4575253..4576077) 1 NC_010498.1 identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system mannose/fructose/sorbose family IID subunit 4576077 6146843 EcSMS35_4477 Escherichia coli SMS-3-5 PTS system mannose/fructose/sorbose family IID subunit YP_001746405.1 4575253 R 439855 CDS YP_001746406.1 170684109 6142882 complement(4576088..4576885) 1 NC_010498.1 identified by match to protein family HMM PF03609; match to protein family HMM TIGR00822; PTS system mannose/fructose/sorbose family IIC subunit 4576885 6142882 EcSMS35_4478 Escherichia coli SMS-3-5 PTS system mannose/fructose/sorbose family IIC subunit YP_001746406.1 4576088 R 439855 CDS YP_001746407.1 170681766 6143409 complement(4576951..4577445) 1 NC_010498.1 identified by match to protein family HMM PF03830; match to protein family HMM TIGR00854; PTS system mannose/fructose/sorbose family IIB subunit 4577445 6143409 EcSMS35_4479 Escherichia coli SMS-3-5 PTS system mannose/fructose/sorbose family IIB subunit YP_001746407.1 4576951 R 439855 CDS YP_001746408.1 170681082 6145957 complement(4577445..4577852) 1 NC_010498.1 identified by match to protein family HMM PF03610; match to protein family HMM TIGR00824; PTS system mannose/fructose/sorbose family IIA subunit 4577852 6145957 EcSMS35_4480 Escherichia coli SMS-3-5 PTS system mannose/fructose/sorbose family IIA subunit YP_001746408.1 4577445 R 439855 CDS YP_001746409.1 170681378 6145264 complement(4577862..4578668) 1 NC_010498.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 4578668 6145264 EcSMS35_4481 Escherichia coli SMS-3-5 sorbitol-6-phosphate 2-dehydrogenase YP_001746409.1 4577862 R 439855 CDS YP_001746410.1 170679743 6145562 complement(4578738..4579685) 1 NC_010498.1 identified by similarity to SP:P37078; match to protein family HMM PF04198; sorbitol operon regulator SorC 4579685 sorC 6145562 sorC Escherichia coli SMS-3-5 sorbitol operon regulator SorC YP_001746410.1 4578738 R 439855 CDS YP_001746411.1 170682433 6143901 4580033..4580905 1 NC_010498.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4580905 rluF 6143901 rluF Escherichia coli SMS-3-5 23S rRNA pseudouridine synthase F YP_001746411.1 4580033 D 439855 CDS YP_001746412.1 170680758 6146632 complement(4580906..4581178) 1 NC_010498.1 hypothetical protein 4581178 6146632 EcSMS35_4484 Escherichia coli SMS-3-5 hypothetical protein YP_001746412.1 4580906 R 439855 CDS YP_001746413.1 170684154 6144933 complement(4581431..4582780) 1 NC_010498.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 4582780 lysC 6144933 lysC Escherichia coli SMS-3-5 aspartate kinase III YP_001746413.1 4581431 R 439855 CDS YP_001746414.1 170682424 6143454 4583305..4584954 1 NC_010498.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4584954 pgi 6143454 pgi Escherichia coli SMS-3-5 glucose-6-phosphate isomerase YP_001746414.1 4583305 D 439855 CDS YP_001746415.1 170683667 6146623 4585308..4585550 1 NC_010498.1 hypothetical protein 4585550 6146623 EcSMS35_4487 Escherichia coli SMS-3-5 hypothetical protein YP_001746415.1 4585308 D 439855 CDS YP_001746416.1 170684025 6142959 4585664..4586302 1 NC_010498.1 hypothetical protein 4586302 6142959 EcSMS35_4488 Escherichia coli SMS-3-5 hypothetical protein YP_001746416.1 4585664 D 439855 CDS YP_001746417.1 170682312 6143324 4586299..4587036 1 NC_010498.1 identified by match to protein family HMM PF06251; hypothetical protein 4587036 6143324 EcSMS35_4489 Escherichia coli SMS-3-5 hypothetical protein YP_001746417.1 4586299 D 439855 CDS YP_001746418.1 170682730 6146511 4587036..4589132 1 NC_010498.1 identified by match to protein family HMM PF06082; putative lipoprotein 4589132 6146511 EcSMS35_4490 Escherichia coli SMS-3-5 putative lipoprotein YP_001746418.1 4587036 D 439855 CDS YP_001746419.1 170681532 6146938 complement(4589179..4589457) 1 NC_010498.1 hypothetical protein 4589457 6146938 EcSMS35_4491 Escherichia coli SMS-3-5 hypothetical protein YP_001746419.1 4589179 R 439855 CDS YP_001746420.1 170681775 6145717 complement(4589454..4589576) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4589576 6145717 EcSMS35_4492 Escherichia coli SMS-3-5 hypothetical protein YP_001746420.1 4589454 R 439855 CDS YP_001746421.1 170680080 6145967 4589672..4590082 1 NC_010498.1 identified by match to protein family HMM PF06146; phosphate-starvation-inducible protein PsiE 4590082 psiE 6145967 psiE Escherichia coli SMS-3-5 phosphate-starvation-inducible protein PsiE YP_001746421.1 4589672 D 439855 CDS YP_001746422.1 170680586 6144244 complement(4590176..4591066) 1 NC_010498.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4591066 malG 6144244 malG Escherichia coli SMS-3-5 maltose transporter permease YP_001746422.1 4590176 R 439855 CDS YP_001746423.1 170684307 6144757 complement(4591081..4592625) 1 NC_010498.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4592625 malF 6144757 malF Escherichia coli SMS-3-5 maltose transporter membrane protein YP_001746423.1 4591081 R 439855 CDS YP_001746424.1 170679620 6143609 complement(4592779..4593969) 1 NC_010498.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4593969 malE 6143609 malE Escherichia coli SMS-3-5 maltose ABC transporter periplasmic protein YP_001746424.1 4592779 R 439855 CDS YP_001746425.1 170683568 6143777 4594334..4595449 1 NC_010498.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4595449 malK 6143777 malK Escherichia coli SMS-3-5 maltose/maltodextrin transporter ATP-binding protein YP_001746425.1 4594334 D 439855 CDS YP_001746426.1 170684303 6142859 4595521..4596861 1 NC_010498.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4596861 lamB 6142859 lamB Escherichia coli SMS-3-5 maltoporin YP_001746426.1 4595521 D 439855 CDS YP_001746427.1 170679616 6143605 4597104..4598024 1 NC_010498.1 identified by match to protein family HMM PF07148; maltose regulon periplasmic protein 4598024 malM 6143605 malM Escherichia coli SMS-3-5 maltose regulon periplasmic protein YP_001746427.1 4597104 D 439855 CDS YP_001746428.1 170680249 6143773 4598294..4599832 1 NC_010498.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4599832 6143773 EcSMS35_4500 Escherichia coli SMS-3-5 hypothetical protein YP_001746428.1 4598294 D 439855 CDS YP_001746429.1 170681022 6144416 4600055..4600552 1 NC_010498.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4600552 ubiC 6144416 ubiC Escherichia coli SMS-3-5 chorismate pyruvate lyase YP_001746429.1 4600055 D 439855 CDS YP_001746430.1 170681494 6145203 4600565..4601437 1 NC_010498.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4601437 ubiA 6145203 ubiA Escherichia coli SMS-3-5 4-hydroxybenzoate octaprenyltransferase YP_001746430.1 4600565 D 439855 CDS YP_001746431.1 170682968 6145679 complement(4601592..4604075) 1 NC_010498.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4604075 plsB 6145679 plsB Escherichia coli SMS-3-5 glycerol-3-phosphate acyltransferase YP_001746431.1 4601592 R 439855 CDS YP_001746432.1 170681059 6147183 4604186..4604554 1 NC_010498.1 identified by match to protein family HMM PF01219; diacylglycerol kinase 4604554 dgkA 6147183 dgkA Escherichia coli SMS-3-5 diacylglycerol kinase YP_001746432.1 4604186 D 439855 CDS YP_001746433.1 170684246 6145240 4604664..4605272 1 NC_010498.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4605272 lexA 6145240 lexA Escherichia coli SMS-3-5 LexA repressor YP_001746433.1 4604664 D 439855 CDS YP_001746434.1 170682064 6143547 4605345..4606670 1 NC_010498.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible SOS response protein 4606670 dinF 6143547 dinF Escherichia coli SMS-3-5 DNA-damage-inducible SOS response protein YP_001746434.1 4605345 D 439855 CDS YP_001746435.1 170682102 6146261 4606786..4606995 1 NC_010498.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4606995 6146261 EcSMS35_4507 Escherichia coli SMS-3-5 putative stress-response protein YP_001746435.1 4606786 D 439855 CDS YP_001746436.1 170683816 6146300 complement(4607037..4607552) 1 NC_010498.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4607552 zur 6146300 zur Escherichia coli SMS-3-5 zinc uptake transcriptional repressor YP_001746436.1 4607037 R 439855 CDS YP_001746437.1 170681723 6143110 4607870..4608874 1 NC_010498.1 identified by similarity to GB:ABB68502.1; hypothetical protein 4608874 6143110 EcSMS35_4509 Escherichia coli SMS-3-5 hypothetical protein YP_001746437.1 4607870 D 439855 CDS YP_001746438.1 170682797 6145911 4609254..4610273 1 NC_010498.1 identified by match to protein family HMM PF01207; match to protein family HMM TIGR00742; tRNA-dihydrouridine synthase A 4610273 dusA 6145911 dusA Escherichia coli SMS-3-5 tRNA-dihydrouridine synthase A YP_001746438.1 4609254 D 439855 CDS YP_001746439.1 170680036 6147006 4610425..4610649 1 NC_010498.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4610649 pspG 6147006 pspG Escherichia coli SMS-3-5 phage shock protein G YP_001746439.1 4610425 D 439855 CDS YP_001746440.1 170681673 6144199 complement(4610815..4611798) 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; quinone oxidoreductase, NADPH-dependent 4611798 qor 6144199 qor Escherichia coli SMS-3-5 quinone oxidoreductase, NADPH-dependent YP_001746440.1 4610815 R 439855 CDS YP_001746441.1 170683120 6145859 4611881..4613296 1 NC_010498.1 unwinds double stranded DNA; replicative DNA helicase 4613296 dnaB 6145859 dnaB Escherichia coli SMS-3-5 replicative DNA helicase YP_001746441.1 4611881 D 439855 CDS YP_001746442.1 170680683 6147339 4613349..4614428 1 NC_010498.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4614428 alr 6147339 alr Escherichia coli SMS-3-5 alanine racemase YP_001746442.1 4613349 D 439855 CDS YP_001746443.1 170683808 6144858 4614681..4615874 1 NC_010498.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4615874 tyrB 6144858 tyrB Escherichia coli SMS-3-5 aromatic amino acid aminotransferase YP_001746443.1 4614681 D 439855 CDS YP_001746444.1 170683124 6143102 complement(4616097..4616600) 1 NC_010498.1 hypothetical protein 4616600 6143102 EcSMS35_4516 Escherichia coli SMS-3-5 hypothetical protein YP_001746444.1 4616097 R 439855 CDS YP_001746445.1 170681544 6147343 4617001..4617714 1 NC_010498.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4617714 aphA 6147343 aphA Escherichia coli SMS-3-5 acid phosphatase/phosphotransferase YP_001746445.1 4617001 D 439855 CDS YP_001746446.1 170679732 6145729 4617825..4618241 1 NC_010498.1 yjbQ; identified by match to protein family HMM PF01894; match to protein family HMM TIGR00149; hypothetical protein 4618241 6145729 EcSMS35_4518 Escherichia coli SMS-3-5 hypothetical protein YP_001746446.1 4617825 D 439855 CDS YP_001746447.1 170680223 6143890 4618245..4618601 1 NC_010498.1 identified by match to protein family HMM PF04237; hypothetical protein 4618601 6143890 EcSMS35_4519 Escherichia coli SMS-3-5 hypothetical protein YP_001746447.1 4618245 D 439855 CDS YP_001746448.1 170684169 6144389 complement(4618636..4621458) 1 NC_010498.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4621458 uvrA 6144389 uvrA Escherichia coli SMS-3-5 excinuclease ABC subunit A YP_001746448.1 4618636 R 439855 CDS YP_001746449.1 170682295 6143470 4621713..4622249 1 NC_010498.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4622249 ssb2 6143470 ssb2 Escherichia coli SMS-3-5 single-stranded DNA-binding protein YP_001746449.1 4621713 D 439855 CDS YP_001746450.1 170682955 6146494 complement(4622348..4622629) 1 NC_010498.1 hypothetical protein 4622629 6146494 EcSMS35_4522 Escherichia coli SMS-3-5 hypothetical protein YP_001746450.1 4622348 R 439855 CDS YP_001746451.1 170680947 6147170 4623059..4624645 1 NC_010498.1 identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 4624645 6147170 EcSMS35_4523 Escherichia coli SMS-3-5 cyclic diguanylate phosphodiesterase domain-containing protein YP_001746451.1 4623059 D 439855 CDS YP_001746452.1 170681589 6145128 complement(4624648..4624971) 1 NC_010498.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4624971 soxS 6145128 soxS Escherichia coli SMS-3-5 DNA-binding transcriptional regulator SoxS YP_001746452.1 4624648 R 439855 CDS YP_001746453.1 170680952 6145774 4625057..4625521 1 NC_010498.1 identified by match to protein family HMM PF00376; match to protein family HMM PF09278; match to protein family HMM TIGR01950; redox-sensitive transcriptional activator SoxR 4625521 soxR 6145774 soxR Escherichia coli SMS-3-5 redox-sensitive transcriptional activator SoxR YP_001746453.1 4625057 D 439855 CDS YP_001746454.1 170681595 6145133 complement(4625724..4625837) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4625837 6145133 EcSMS35_4526 Escherichia coli SMS-3-5 hypothetical protein YP_001746454.1 4625724 R 439855 CDS YP_001746455.1 170681500 6145780 4626066..4627415 1 NC_010498.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease family inorganic anion transporter 4627415 6145780 EcSMS35_4527 Escherichia coli SMS-3-5 sulfate permease family inorganic anion transporter YP_001746455.1 4626066 D 439855 CDS YP_001746456.1 170682054 6145685 4627566..4629215 1 NC_010498.1 yjcE; identified by match to protein family HMM PF00999; match to protein family HMM TIGR00831; Na+/H+ antiporter 4629215 6145685 EcSMS35_4528 Escherichia coli SMS-3-5 Na+/H+ antiporter YP_001746456.1 4627566 D 439855 CDS YP_001746457.1 170682571 6146251 complement(4629297..4630946) 1 NC_010498.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4630946 actP 6146251 actP Escherichia coli SMS-3-5 acetate permease YP_001746457.1 4629297 R 439855 CDS YP_001746458.1 170683632 6146776 complement(4630943..4631257) 1 NC_010498.1 identified by match to protein family HMM PF04341; hypothetical protein 4631257 6146776 EcSMS35_4530 Escherichia coli SMS-3-5 hypothetical protein YP_001746458.1 4630943 R 439855 CDS YP_001746459.1 170683866 6142923 complement(4631470..4633428) 1 NC_010498.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4633428 acsA 6142923 acsA Escherichia coli SMS-3-5 acetyl-CoA synthetase YP_001746459.1 4631470 R 439855 CDS YP_001746460.1 170679805 6143161 4633821..4635257 1 NC_010498.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4635257 nrfA 6143161 nrfA Escherichia coli SMS-3-5 cytochrome c552 YP_001746460.1 4633821 D 439855 CDS YP_001746461.1 170679854 6143966 4635303..4635869 1 NC_010498.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4635869 nrfB 6143966 nrfB Escherichia coli SMS-3-5 cytochrome c nitrite reductase pentaheme subunit YP_001746461.1 4635303 D 439855 CDS YP_001746462.1 170680331 6144016 4635866..4636537 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409; match to protein family HMM TIGR03149; cytochrome c nitrite reductase, Fe-S protein 4636537 nrfC 6144016 nrfC Escherichia coli SMS-3-5 cytochrome c nitrite reductase, Fe-S protein YP_001746462.1 4635866 D 439855 CDS YP_001746463.1 170682297 6144499 4636534..4637490 1 NC_010498.1 identified by match to protein family HMM PF03916; match to protein family HMM TIGR03148; nrfD protein 4637490 nrfD 6144499 nrfD Escherichia coli SMS-3-5 nrfD protein YP_001746463.1 4636534 D 439855 CDS YP_001746464.1 170682982 6146496 4637546..4639228 1 NC_010498.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4639228 nrfE 6146496 nrfE Escherichia coli SMS-3-5 heme lyase subunit NrfE YP_001746464.1 4637546 D 439855 CDS YP_001746465.1 170681132 6147197 4639221..4639604 1 NC_010498.1 identified by match to protein family HMM PF03918; match to protein family HMM TIGR03147; formate-dependent nitrite reductase complex subunit NrfF 4639604 nrfF 6147197 nrfF Escherichia coli SMS-3-5 formate-dependent nitrite reductase complex subunit NrfF YP_001746465.1 4639221 D 439855 CDS YP_001746466.1 170682998 6145315 4639601..4640197 1 NC_010498.1 identified by match to protein family HMM PF00515; match to protein family HMM PF07719; formate-dependent nitrite reductase complex subunit NrfG 4640197 nrfG 6145315 nrfG Escherichia coli SMS-3-5 formate-dependent nitrite reductase complex subunit NrfG YP_001746466.1 4639601 D 439855 CDS YP_001746467.1 170682815 6147214 complement(4640331..4640462) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4640462 6147214 EcSMS35_4539 Escherichia coli SMS-3-5 hypothetical protein YP_001746467.1 4640331 R 439855 CDS YP_001746468.1 170684035 6147026 4640539..4641852 1 NC_010498.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4641852 gltP 6147026 gltP Escherichia coli SMS-3-5 glutamate/aspartate:proton symporter YP_001746468.1 4640539 D 439855 CDS YP_001746469.1 170682484 6143334 complement(4642044..4642733) 1 NC_010498.1 identified by match to protein family HMM PF08238; Sel1 repeat-containing protein 4642733 6143334 EcSMS35_4541 Escherichia coli SMS-3-5 Sel1 repeat-containing protein YP_001746469.1 4642044 R 439855 CDS YP_001746470.1 170683812 6146683 complement(4642827..4644974) 1 NC_010498.1 Selenoprotein. identified by similarity to SP:P07658; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591; formate dehydrogenase H, alpha subunit, selenocysteine-containing 4644974 fdhF 6146683 fdhF Escherichia coli SMS-3-5 formate dehydrogenase H, alpha subunit, selenocysteine-containing YP_001746470.1 4642827 R 439855 CDS YP_001746471.1 170680574 6143106 4645036..4645149 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4645149 6143106 EcSMS35_4543 Escherichia coli SMS-3-5 hypothetical protein YP_001746471.1 4645036 D 439855 CDS YP_001746472.1 170681660 6144744 complement(4645172..4646638) 1 NC_010498.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP 4646638 6144744 EcSMS35_4544 Escherichia coli SMS-3-5 putative outer membrane efflux protein MdtP YP_001746472.1 4645172 R 439855 CDS YP_001746473.1 170681173 6145846 complement(4646635..4648686) 1 NC_010498.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4648686 mdtO 6145846 mdtO Escherichia coli SMS-3-5 multidrug efflux system protein MdtO YP_001746473.1 4646635 R 439855 CDS YP_001746474.1 170681502 6145357 complement(4648686..4649717) 1 NC_010498.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4649717 mdtN 6145357 mdtN Escherichia coli SMS-3-5 multidrug resistance protein MdtN YP_001746474.1 4648686 R 439855 CDS YP_001746475.1 170681616 6145687 complement(4649736..4650011) 1 NC_010498.1 hypothetical protein 4650011 6145687 EcSMS35_4547 Escherichia coli SMS-3-5 hypothetical protein YP_001746475.1 4649736 R 439855 CDS YP_001746476.1 170680201 6145801 complement(4650128..4650247) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4650247 6145801 EcSMS35_4548 Escherichia coli SMS-3-5 hypothetical protein YP_001746476.1 4650128 R 439855 CDS YP_001746477.1 170680012 6144367 complement(4650220..4652205) 1 NC_010498.1 identified by match to protein family HMM PF00753; metallo-beta-lactamase family protein 4652205 6144367 EcSMS35_4549 Escherichia coli SMS-3-5 metallo-beta-lactamase family protein YP_001746477.1 4650220 R 439855 CDS YP_001746478.1 170680209 6144175 complement(4652478..4653407) 1 NC_010498.1 identified by similarity to SP:P32718; match to protein family HMM PF00480; D-allose kinase 4653407 alsK 6144175 alsK Escherichia coli SMS-3-5 D-allose kinase YP_001746478.1 4652478 R 439855 CDS YP_001746479.1 170679730 6144375 complement(4653391..4654086) 1 NC_010498.1 identified by similarity to SP:P32719; match to protein family HMM PF00834; allulose-6-phosphate 3-epimerase 4654086 alsE 6144375 alsE Escherichia coli SMS-3-5 allulose-6-phosphate 3-epimerase YP_001746479.1 4653391 R 439855 CDS YP_001746480.1 170684183 6143888 complement(4654097..4655077) 1 NC_010498.1 identified by similarity to SP:P32720; match to protein family HMM PF02653; D-allose transporter subunit 4655077 alsC 6143888 alsC Escherichia coli SMS-3-5 D-allose transporter subunit YP_001746480.1 4654097 R 439855 CDS YP_001746481.1 170683675 6143484 complement(4655056..4656588) 1 NC_010498.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein 4656588 alsA 6143484 alsA Escherichia coli SMS-3-5 D-allose transporter ATP-binding protein YP_001746481.1 4655056 R 439855 CDS YP_001746482.1 170682838 6142967 complement(4656716..4657657) 1 NC_010498.1 identified by similarity to SP:P39265; match to protein family HMM PF00532; D-allose transporter subunit 4657657 alsB 6142967 alsB Escherichia coli SMS-3-5 D-allose transporter subunit YP_001746482.1 4656716 R 439855 CDS YP_001746483.1 170681425 6147049 complement(4657710..4658600) 1 NC_010498.1 involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR 4658600 rpiR 6147049 rpiR Escherichia coli SMS-3-5 DNA-binding transcriptional repressor RpiR YP_001746483.1 4657710 R 439855 CDS YP_001746484.1 170683862 6145609 4658959..4659408 1 NC_010498.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4659408 rpiB 6145609 rpiB Escherichia coli SMS-3-5 ribose-5-phosphate isomerase B YP_001746484.1 4658959 D 439855 CDS YP_001746485.1 170679592 6143157 4659477..4659806 1 NC_010498.1 hypothetical protein 4659806 6143157 EcSMS35_4557 Escherichia coli SMS-3-5 hypothetical protein YP_001746485.1 4659477 D 439855 CDS YP_001746486.1 170681563 6143749 complement(4659841..4660599) 1 NC_010498.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4660599 phnP 6143749 phnP Escherichia coli SMS-3-5 carbon-phosphorus lyase complex accessory protein YP_001746486.1 4659841 R 439855 CDS YP_001746487.1 170683288 6145748 complement(4660601..4661035) 1 NC_010498.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4661035 6145748 EcSMS35_4559 Escherichia coli SMS-3-5 aminoalkylphosphonic acid N-acetyltransferase YP_001746487.1 4660601 R 439855 CDS YP_001746488.1 170680468 6147514 complement(4661022..4661579) 1 NC_010498.1 identified by match to protein family HMM TIGR02322; ribose 1,5-bisphosphokinase 4661579 phnN 6147514 phnN Escherichia coli SMS-3-5 ribose 1,5-bisphosphokinase YP_001746488.1 4661022 R 439855 CDS YP_001746489.1 170682245 6144637 complement(4661579..4662715) 1 NC_010498.1 identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR02318; phosphonate metabolism protein PhnM 4662715 phnM 6144637 phnM Escherichia coli SMS-3-5 phosphonate metabolism protein PhnM YP_001746489.1 4661579 R 439855 CDS YP_001746490.1 170684197 6146444 complement(4662712..4663392) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR02324; phosphonate C-P lyase system protein PhnL 4663392 phnL 6146444 phnL Escherichia coli SMS-3-5 phosphonate C-P lyase system protein PhnL YP_001746490.1 4662712 R 439855 CDS YP_001746491.1 170681420 6143498 complement(4663503..4664261) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR02323; phosphonate C-P lyase system protein PhnK 4664261 phnK 6143498 phnK Escherichia coli SMS-3-5 phosphonate C-P lyase system protein PhnK YP_001746491.1 4663503 R 439855 CDS YP_001746492.1 170680761 6145604 complement(4664258..4665103) 1 NC_010498.1 identified by match to protein family HMM PF06007; phosphonate metabolism protein PhnJ 4665103 phnJ 6145604 phnJ Escherichia coli SMS-3-5 phosphonate metabolism protein PhnJ YP_001746492.1 4664258 R 439855 CDS YP_001746493.1 170680400 6144936 complement(4665096..4666160) 1 NC_010498.1 identified by match to protein family HMM PF05861; phosphonate metabolism protein PhnI 4666160 phnI 6144936 phnI Escherichia coli SMS-3-5 phosphonate metabolism protein PhnI YP_001746493.1 4665096 R 439855 CDS YP_001746494.1 170683832 6144569 complement(4666160..4666744) 1 NC_010498.1 identified by match to protein family HMM PF05845; match to protein family HMM TIGR03292; carbon-phosphorus lyase complex subunit 4666744 phnH 6144569 phnH Escherichia coli SMS-3-5 carbon-phosphorus lyase complex subunit YP_001746494.1 4666160 R 439855 CDS YP_001746495.1 170682088 6143126 complement(4666741..4667193) 1 NC_010498.1 identified by match to protein family HMM PF06754; match to protein family HMM TIGR03293; phosphonate C-P lyase system protein PhnG 4667193 phnG 6143126 phnG Escherichia coli SMS-3-5 phosphonate C-P lyase system protein PhnG YP_001746495.1 4666741 R 439855 CDS YP_001746496.1 170682760 6146285 complement(4667194..4667919) 1 NC_010498.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4667919 phnF 6146285 phnF Escherichia coli SMS-3-5 phosphonate metabolism transcriptional regulator PhnF YP_001746496.1 4667194 R 439855 CDS YP_001746497.1 170680687 6146969 complement(4667940..4668719) 1 NC_010498.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01097; phosphonate ABC transporter permease 4668719 phnE 6146969 phnE Escherichia coli SMS-3-5 phosphonate ABC transporter permease YP_001746497.1 4667940 R 439855 CDS YP_001746498.1 170681158 6144862 complement(4668784..4669800) 1 NC_010498.1 identified by match to protein family HMM TIGR01098; match to protein family HMM TIGR03431; phosphonate ABC transporter periplasmic phosphonate-binding protein 4669800 phnD 6144862 phnD Escherichia coli SMS-3-5 phosphonate ABC transporter periplasmic phosphonate-binding protein YP_001746498.1 4668784 R 439855 CDS YP_001746499.1 170683786 6145342 complement(4669825..4670613) 1 NC_010498.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR02315; phosphonate/organophosphate ester transporter subunit 4670613 phnC 6145342 phnC Escherichia coli SMS-3-5 phosphonate/organophosphate ester transporter subunit YP_001746499.1 4669825 R 439855 CDS YP_001746500.1 170680128 6143078 complement(4670746..4671189) 1 NC_010498.1 identified by match to protein family HMM PF00903; hypothetical protein 4671189 6143078 EcSMS35_4572 Escherichia coli SMS-3-5 hypothetical protein YP_001746500.1 4670746 R 439855 CDS YP_001746501.1 170682790 6144293 complement(4671349..4671762) 1 NC_010498.1 identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA 4671762 phnA 6144293 phnA Escherichia coli SMS-3-5 alkylphosphonate utilization operon protein PhnA YP_001746501.1 4671349 R 439855 CDS YP_001746502.1 170683254 6146999 4672087..4674315 1 NC_010498.1 hypothetical protein 4674315 6146999 EcSMS35_4574 Escherichia coli SMS-3-5 hypothetical protein YP_001746502.1 4672087 D 439855 CDS YP_001746503.1 170681186 6147477 4674312..4675190 1 NC_010498.1 hypothetical protein 4675190 6147477 EcSMS35_4575 Escherichia coli SMS-3-5 hypothetical protein YP_001746503.1 4674312 D 439855 CDS YP_001746504.1 170680520 6145370 4675454..4676956 1 NC_010498.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM PF08946; match to protein family HMM TIGR00883; proline/glycine betaine transporter 4676956 proP 6145370 proP Escherichia coli SMS-3-5 proline/glycine betaine transporter YP_001746504.1 4675454 D 439855 CDS YP_001746505.1 170683891 6144690 complement(4677133..4678233) 1 NC_010498.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein BasS/PmrB 4678233 basS 6144690 basS Escherichia coli SMS-3-5 sensor protein BasS/PmrB YP_001746505.1 4677133 R 439855 CDS YP_001746506.1 170679832 6143186 complement(4678234..4678902) 1 NC_010498.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4678902 basR 6143186 basR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator BasR YP_001746506.1 4678234 R 439855 CDS YP_001746507.1 170683071 6143994 complement(4678899..4680542) 1 NC_010498.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein 4680542 6143994 EcSMS35_4579 Escherichia coli SMS-3-5 putative cell division protein YP_001746507.1 4678899 R 439855 CDS YP_001746508.1 170683422 6147288 complement(4680646..4681983) 1 NC_010498.1 identified by match to protein family HMM PF00324; arginine:agmatin antiporter 4681983 adiC 6147288 adiC Escherichia coli SMS-3-5 arginine:agmatin antiporter YP_001746508.1 4680646 R 439855 CDS YP_001746509.1 170681441 6142709 complement(4682120..4682881) 1 NC_010498.1 identified by match to protein family HMM PF00165; transcriptional regulator AdiY 4682881 adiY 6142709 adiY Escherichia coli SMS-3-5 transcriptional regulator AdiY YP_001746509.1 4682120 R 439855 CDS YP_001746510.1 170682390 6145625 complement(4682838..4682975) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4682975 6145625 EcSMS35_4582 Escherichia coli SMS-3-5 hypothetical protein YP_001746510.1 4682838 R 439855 CDS YP_001746511.1 170680968 6146589 complement(4683217..4685487) 1 NC_010498.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; biodegradative arginine decarboxylase 4685487 adiA 6146589 adiA Escherichia coli SMS-3-5 biodegradative arginine decarboxylase YP_001746511.1 4683217 R 439855 CDS YP_001746512.1 170681448 6145149 complement(4685683..4686591) 1 NC_010498.1 identified by match to protein family HMM PF00165; DNA-binding transcriptional regulator MelR 4686591 melR 6145149 melR Escherichia coli SMS-3-5 DNA-binding transcriptional regulator MelR YP_001746512.1 4685683 R 439855 CDS YP_001746513.1 170684090 6145633 4686874..4688229 1 NC_010498.1 identified by match to protein family HMM PF02056; alpha-galactosidase 4688229 melA 6145633 melA Escherichia coli SMS-3-5 alpha-galactosidase YP_001746513.1 4686874 D 439855 CDS YP_001746514.1 170680691 6143390 4688308..4689753 1 NC_010498.1 identified by match to protein family HMM TIGR00792; melibiose:sodium symporter 4689753 melB 6143390 melB Escherichia coli SMS-3-5 melibiose:sodium symporter YP_001746514.1 4688308 D 439855 CDS YP_001746515.1 170681045 6144866 complement(4689892..4690521) 1 NC_010498.1 hypothetical protein 4690521 6144866 EcSMS35_4587 Escherichia coli SMS-3-5 hypothetical protein YP_001746515.1 4689892 R 439855 CDS YP_001746516.1 170681722 6145226 complement(4690644..4692290) 1 NC_010498.1 identified by similarity to SP:P14407; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase class I, anaerobic 4692290 fumB 6145226 fumB Escherichia coli SMS-3-5 fumarate hydratase class I, anaerobic YP_001746516.1 4690644 R 439855 CDS YP_001746517.1 170682748 6145910 complement(4692368..4693708) 1 NC_010498.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4693708 dcuB 6145910 dcuB Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001746517.1 4692368 R 439855 CDS YP_001746518.1 170680999 6146956 4693776..4693934 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4693934 6146956 EcSMS35_4590 Escherichia coli SMS-3-5 hypothetical protein YP_001746518.1 4693776 D 439855 CDS YP_001746519.1 170682337 6145180 complement(4694279..4694998) 1 NC_010498.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4694998 dcuR 6145180 dcuR Escherichia coli SMS-3-5 DNA-binding transcriptional activator DcuR YP_001746519.1 4694279 R 439855 CDS YP_001746520.1 170682025 6146536 complement(4694995..4696626) 1 NC_010498.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4696626 dcuS 6146536 dcuS Escherichia coli SMS-3-5 sensory histidine kinase DcuS YP_001746520.1 4694995 R 439855 CDS YP_001746521.1 170683017 6146222 4696618..4696752 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4696752 6146222 EcSMS35_4593 Escherichia coli SMS-3-5 hypothetical protein YP_001746521.1 4696618 D 439855 CDS YP_001746522.1 170682530 6147233 4696807..4697037 1 NC_010498.1 identified by match to protein family HMM PF06902; hypothetical protein 4697037 6147233 EcSMS35_4594 Escherichia coli SMS-3-5 hypothetical protein YP_001746522.1 4696807 D 439855 CDS YP_001746523.1 170679668 6146731 4697049..4697321 1 NC_010498.1 hypothetical protein 4697321 6146731 EcSMS35_4595 Escherichia coli SMS-3-5 hypothetical protein YP_001746523.1 4697049 D 439855 CDS YP_001746524.1 170683387 6143826 4697640..4697846 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4697846 6143826 EcSMS35_4596 Escherichia coli SMS-3-5 hypothetical protein YP_001746524.1 4697640 D 439855 CDS YP_001746525.1 170682549 6142673 4697874..4698047 1 NC_010498.1 hypothetical protein 4698047 6142673 EcSMS35_4597 Escherichia coli SMS-3-5 hypothetical protein YP_001746525.1 4697874 D 439855 CDS YP_001746526.1 170682016 6146751 complement(4698166..4699683) 1 NC_010498.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4699683 lysU 6146751 lysU Escherichia coli SMS-3-5 lysyl-tRNA synthetase YP_001746526.1 4698166 R 439855 CDS YP_001746527.1 170682504 6146213 complement(4699920..4701377) 1 NC_010498.1 identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; amino acid/peptide transporter 4701377 6146213 EcSMS35_4599 Escherichia coli SMS-3-5 amino acid/peptide transporter YP_001746527.1 4699920 R 439855 CDS YP_001746528.1 170681667 6146704 complement(4701436..4703583) 1 NC_010498.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; lysine decarboxylase, constitutive 4703583 ldcC2 6146704 ldcC2 Escherichia coli SMS-3-5 lysine decarboxylase, constitutive YP_001746528.1 4701436 R 439855 CDS YP_001746529.1 170681514 6145853 complement(4703663..4704997) 1 NC_010498.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4704997 cadB 6145853 cadB Escherichia coli SMS-3-5 lysine/cadaverine antiporter YP_001746529.1 4703663 R 439855 CDS YP_001746530.1 170681004 6145699 complement(4705363..4706901) 1 NC_010498.1 regulates the cadBA operon; DNA-binding transcriptional activator CadC 4706901 cadC 6145699 cadC Escherichia coli SMS-3-5 DNA-binding transcriptional activator CadC YP_001746530.1 4705363 R 439855 CDS YP_001746531.1 170679619 6143659 complement(4707700..4708275) 1 NC_010498.1 identified by match to protein family HMM PF00440; putative transcriptional regulator 4708275 6143659 EcSMS35_4604 Escherichia coli SMS-3-5 putative transcriptional regulator YP_001746531.1 4707700 R 439855 CDS YP_001746532.1 170683820 6143776 complement(4708312..4710009) 1 NC_010498.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein precursor 4710009 dipZ 6143776 dipZ Escherichia coli SMS-3-5 thiol:disulfide interchange protein precursor YP_001746532.1 4708312 R 439855 CDS YP_001746533.1 170683216 6143114 complement(4709985..4710323) 1 NC_010498.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4710323 cutA 6143114 cutA Escherichia coli SMS-3-5 divalent-cation tolerance protein CutA YP_001746533.1 4709985 R 439855 CDS YP_001746534.1 170681409 6147437 complement(4710439..4711740) 1 NC_010498.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4711740 dcuA 6147437 dcuA Escherichia coli SMS-3-5 anaerobic C4-dicarboxylate transporter YP_001746534.1 4710439 R 439855 CDS YP_001746535.1 170680757 6145593 complement(4711858..4713294) 1 NC_010498.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4713294 aspA 6145593 aspA Escherichia coli SMS-3-5 aspartate ammonia-lyase YP_001746535.1 4711858 R 439855 CDS YP_001746536.1 170682612 6144932 4713631..4714107 1 NC_010498.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4714107 fxsA 6144932 fxsA Escherichia coli SMS-3-5 FxsA YP_001746536.1 4713631 D 439855 CDS YP_001746537.1 170683031 6146817 complement(4714123..4715379) 1 NC_010498.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH 4715379 6146817 EcSMS35_4610 Escherichia coli SMS-3-5 inner membrane protein YjeH YP_001746537.1 4714123 R 439855 CDS YP_001746538.1 170682323 6147247 4715655..4715948 1 NC_010498.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4715948 groES 6147247 groES Escherichia coli SMS-3-5 co-chaperonin GroES YP_001746538.1 4715655 D 439855 CDS YP_001746539.1 170684024 6146522 4715992..4717638 1 NC_010498.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4717638 groEL 6146522 groEL Escherichia coli SMS-3-5 chaperonin GroEL YP_001746539.1 4715992 D 439855 CDS YP_001746540.1 170680450 6143323 4717773..4718126 1 NC_010498.1 putative lipoprotein 4718126 6143323 EcSMS35_4613 Escherichia coli SMS-3-5 putative lipoprotein YP_001746540.1 4717773 D 439855 CDS YP_001746541.1 170680411 6144619 complement(4718176..4719045) 1 NC_010498.1 hypothetical protein 4719045 6144619 EcSMS35_4614 Escherichia coli SMS-3-5 hypothetical protein YP_001746541.1 4718176 R 439855 CDS YP_001746542.1 170679776 6144580 complement(4719280..4720308) 1 NC_010498.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR00238; KamA family protein 4720308 6144580 EcSMS35_4615 Escherichia coli SMS-3-5 KamA family protein YP_001746542.1 4719280 R 439855 CDS YP_001746543.1 170681454 6143935 4720350..4720916 1 NC_010498.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4720916 efp 6143935 efp Escherichia coli SMS-3-5 elongation factor P YP_001746543.1 4720350 D 439855 CDS YP_001746544.1 170684149 6145639 4720968..4721093 1 NC_010498.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4721093 ecnA 6145639 ecnA Escherichia coli SMS-3-5 entericidin A YP_001746544.1 4720968 D 439855 CDS YP_001746545.1 170682398 6143449 4721204..4721350 1 NC_010498.1 identified by similarity to SP:P0ADB7; match to protein family HMM PF08085; entericidin B membrane lipoprotein 4721350 ecnB 6143449 ecnB Escherichia coli SMS-3-5 entericidin B membrane lipoprotein YP_001746545.1 4721204 D 439855 CDS YP_001746546.1 170682553 6146597 4721525..4721842 1 NC_010498.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4721842 sugE 6146597 sugE Escherichia coli SMS-3-5 quaternary ammonium compound-resistance protein SugE YP_001746546.1 4721525 D 439855 CDS YP_001746547.1 170683090 6146756 complement(4721839..4722372) 1 NC_010498.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4722372 blc 6146756 blc Escherichia coli SMS-3-5 outer membrane lipoprotein Blc YP_001746547.1 4721839 R 439855 CDS YP_001746548.1 170681215 6147308 complement(4722460..4723593) 1 NC_010498.1 identified by match to protein family HMM PF00144; beta-lactamase 4723593 ampC 6147308 ampC Escherichia coli SMS-3-5 beta-lactamase YP_001746548.1 4722460 R 439855 CDS YP_001746549.1 170681524 6145399 complement(4723656..4724015) 1 NC_010498.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4724015 frdD 6145399 frdD Escherichia coli SMS-3-5 fumarate reductase subunit D YP_001746549.1 4723656 R 439855 CDS YP_001746550.1 170679861 6145709 complement(4724026..4724421) 1 NC_010498.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4724421 frdC 6145709 frdC Escherichia coli SMS-3-5 fumarate reductase subunit C YP_001746550.1 4724026 R 439855 CDS YP_001746551.1 170679761 6144023 complement(4724432..4725166) 1 NC_010498.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4725166 frdB 6144023 frdB Escherichia coli SMS-3-5 fumarate reductase iron-sulfur subunit YP_001746551.1 4724432 R 439855 CDS YP_001746552.1 170680383 6143920 complement(4725159..4726967) 1 NC_010498.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4726967 frdA 6143920 frdA Escherichia coli SMS-3-5 fumarate reductase flavoprotein subunit YP_001746552.1 4725159 R 439855 CDS YP_001746553.1 170684036 6144552 4727292..4728269 1 NC_010498.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4728269 genX 6144552 genX Escherichia coli SMS-3-5 lysyl-tRNA synthetase YP_001746553.1 4727292 D 439855 CDS YP_001746554.1 170680322 6143335 4728446..4729990 1 NC_010498.1 identified by match to protein family HMM PF00324; amino acid permease family protein 4729990 6143335 EcSMS35_4627 Escherichia coli SMS-3-5 amino acid permease family protein YP_001746554.1 4728446 D 439855 CDS YP_001746555.1 170683533 6144490 4730053..4730367 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4730367 6144490 EcSMS35_4628 Escherichia coli SMS-3-5 hypothetical protein YP_001746555.1 4730053 D 439855 CDS YP_001746556.1 170684077 6142823 4730376..4730678 1 NC_010498.1 identified by similarity to SP:P39284; hypothetical protein 4730678 6142823 EcSMS35_4629 Escherichia coli SMS-3-5 hypothetical protein YP_001746556.1 4730376 D 439855 CDS YP_001746557.1 170682564 6143377 complement(4730709..4734032) 1 NC_010498.1 identified by match to protein family HMM PF00924; hypothetical protein 4734032 6143377 EcSMS35_4630 Escherichia coli SMS-3-5 hypothetical protein YP_001746557.1 4730709 R 439855 CDS YP_001746558.1 170682986 6146767 complement(4734054..4735022) 1 NC_010498.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4735022 psd 6146767 psd Escherichia coli SMS-3-5 phosphatidylserine decarboxylase YP_001746558.1 4734054 R 439855 CDS YP_001746559.1 170681485 6147202 complement(4735118..4736170) 1 NC_010498.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4736170 rsgA 6147202 rsgA Escherichia coli SMS-3-5 ribosome-associated GTPase YP_001746559.1 4735118 R 439855 CDS YP_001746560.1 170681955 6145670 4736265..4736810 1 NC_010498.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4736810 orn 6145670 orn Escherichia coli SMS-3-5 oligoribonuclease YP_001746560.1 4736265 D 439855 CDS YP_001746561.1 170680505 6143627 complement(4737710..4738849) 1 NC_010498.1 identified by match to protein family HMM PF00037; match to protein family HMM PF08331; match to protein family HMM TIGR00276; iron-sulfur cluster binding protein 4738849 6143627 EcSMS35_4637 Escherichia coli SMS-3-5 iron-sulfur cluster binding protein YP_001746561.1 4737710 R 439855 CDS YP_001746562.1 170680990 6144675 4738863..4740395 1 NC_010498.1 identified by match to protein family HMM PF01256; match to protein family HMM PF03853; match to protein family HMM TIGR00196; match to protein family HMM TIGR00197; hypothetical protein 4740395 6144675 EcSMS35_4638 Escherichia coli SMS-3-5 hypothetical protein YP_001746562.1 4738863 D 439855 CDS YP_001746563.1 170684296 6145171 4740370..4740828 1 NC_010498.1 possibly involved in cell wall synthesis; putative ATPase 4740828 6145171 EcSMS35_4639 Escherichia coli SMS-3-5 putative ATPase YP_001746563.1 4740370 D 439855 CDS YP_001746564.1 170680514 6143598 4740847..4742184 1 NC_010498.1 identified by similarity to SP:P26365; match to protein family HMM PF01520; N-acetylmuramoyl-l-alanine amidase II 4742184 amiB 6143598 amiB Escherichia coli SMS-3-5 N-acetylmuramoyl-l-alanine amidase II YP_001746564.1 4740847 D 439855 CDS YP_001746565.1 170681264 6144684 4742194..4744041 1 NC_010498.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4744041 mutL 6144684 mutL Escherichia coli SMS-3-5 DNA mismatch repair protein YP_001746565.1 4742194 D 439855 CDS YP_001746566.1 170681902 6145448 4744034..4744984 1 NC_010498.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4744984 miaA 6145448 miaA Escherichia coli SMS-3-5 tRNA delta(2)-isopentenylpyrophosphate transferase YP_001746566.1 4744034 D 439855 CDS YP_001746567.1 170681233 6146097 4745070..4745378 1 NC_010498.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4745378 hfq 6146097 hfq Escherichia coli SMS-3-5 RNA-binding protein Hfq YP_001746567.1 4745070 D 439855 CDS YP_001746568.1 170681964 6145417 4745454..4746734 1 NC_010498.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4746734 hflX 6145417 hflX Escherichia coli SMS-3-5 putative GTPase HflX YP_001746568.1 4745454 D 439855 CDS YP_001746569.1 170682628 6146160 4746820..4748079 1 NC_010498.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4748079 hflK 6146160 hflK Escherichia coli SMS-3-5 FtsH protease regulator HflK YP_001746569.1 4746820 D 439855 CDS YP_001746570.1 170683296 6146834 4748082..4749086 1 NC_010498.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4749086 hflC 6146834 hflC Escherichia coli SMS-3-5 FtsH protease regulator HflC YP_001746570.1 4748082 D 439855 CDS YP_001746571.1 170683957 6147522 4749168..4749365 1 NC_010498.1 hypothetical protein 4749365 6147522 EcSMS35_4647 Escherichia coli SMS-3-5 hypothetical protein YP_001746571.1 4749168 D 439855 CDS YP_001746572.1 170679879 6143254 4749469..4750767 1 NC_010498.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4750767 purA 6143254 purA Escherichia coli SMS-3-5 adenylosuccinate synthetase YP_001746572.1 4749469 D 439855 CDS YP_001746573.1 170680746 6144041 4750972..4751397 1 NC_010498.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4751397 nsrR 6144041 nsrR Escherichia coli SMS-3-5 transcriptional repressor NsrR YP_001746573.1 4750972 D 439855 CDS YP_001746574.1 170681596 6144921 4751436..4753877 1 NC_010498.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4753877 rnr 6144921 rnr Escherichia coli SMS-3-5 exoribonuclease R YP_001746574.1 4751436 D 439855 CDS YP_001746575.1 170679577 6145781 4754058..4754789 1 NC_010498.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4754789 6145781 EcSMS35_4651 Escherichia coli SMS-3-5 23S rRNA (guanosine-2'-O-)-methyltransferase YP_001746575.1 4754058 D 439855 CDS YP_001746576.1 170680276 6143734 4754916..4755317 1 NC_010498.1 hypothetical protein 4755317 6143734 EcSMS35_4652 Escherichia coli SMS-3-5 hypothetical protein YP_001746576.1 4754916 D 439855 CDS YP_001746577.1 170681960 6144443 4755336..4756034 1 NC_010498.1 identified by match to protein family HMM PF04012; PspA/IM30 family protein 4756034 6144443 EcSMS35_4653 Escherichia coli SMS-3-5 PspA/IM30 family protein YP_001746577.1 4755336 D 439855 CDS YP_001746578.1 170682609 6146156 4756084..4756743 1 NC_010498.1 hypothetical protein 4756743 6146156 EcSMS35_4654 Escherichia coli SMS-3-5 hypothetical protein YP_001746578.1 4756084 D 439855 CDS YP_001746579.1 170681229 6146814 4756761..4757159 1 NC_010498.1 identified by match to protein family HMM PF03994; putative inner membrane protein 4757159 6146814 EcSMS35_4655 Escherichia coli SMS-3-5 putative inner membrane protein YP_001746579.1 4756761 D 439855 CDS YP_001746580.1 170681917 6145413 4757169..4757807 1 NC_010498.1 identified by match to protein family HMM PF06693; hypothetical protein 4757807 6145413 EcSMS35_4656 Escherichia coli SMS-3-5 hypothetical protein YP_001746580.1 4757169 D 439855 CDS YP_001746581.1 170679916 6146112 4757810..4758973 1 NC_010498.1 identified by match to protein family HMM PF03738; glutathionylspermidine synthase domain-containing protein 4758973 6146112 EcSMS35_4657 Escherichia coli SMS-3-5 glutathionylspermidine synthase domain-containing protein YP_001746581.1 4757810 D 439855 CDS YP_001746582.1 170680540 6144078 4759057..4760682 1 NC_010498.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4760682 6144078 EcSMS35_4658 Escherichia coli SMS-3-5 isovaleryl CoA dehydrogenase YP_001746582.1 4759057 D 439855 CDS YP_001746583.1 170680407 6144710 complement(4760799..4761086) 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 4761086 6144710 EcSMS35_4659 Escherichia coli SMS-3-5 hypothetical protein YP_001746583.1 4760799 R 439855 CDS YP_001746584.1 170682725 6144576 complement(4761223..4761552) 1 NC_010498.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A 4761552 6144576 EcSMS35_4660 Escherichia coli SMS-3-5 putative biofilm stress and motility protein A YP_001746584.1 4761223 R 439855 CDS YP_001746585.1 170682439 6146933 4761734..4762483 1 NC_010498.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4762483 6146933 EcSMS35_4662 Escherichia coli SMS-3-5 esterase YP_001746585.1 4761734 D 439855 CDS YP_001746586.1 170680953 6146638 complement(4762480..4763235) 1 NC_010498.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4763235 ulaR 6146638 ulaR Escherichia coli SMS-3-5 transcriptional repressor UlaR YP_001746586.1 4762480 R 439855 CDS YP_001746587.1 170682852 6145134 complement(4763343..4764407) 1 NC_010498.1 putative L-ascorbate 6-phosphate lactonase 4764407 6145134 EcSMS35_4663 Escherichia coli SMS-3-5 putative L-ascorbate 6-phosphate lactonase YP_001746587.1 4763343 R 439855 CDS YP_001746588.1 170680215 6147065 4764762..4766159 1 NC_010498.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4766159 ulaA 6147065 ulaA Escherichia coli SMS-3-5 PTS system ascorbate-specific transporter subunit IIC YP_001746588.1 4764762 D 439855 CDS YP_001746589.1 170684161 6144381 4766175..4766480 1 NC_010498.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4766480 ulaB 6144381 ulaB Escherichia coli SMS-3-5 PTS system L-ascorbate-specific transporter subunit IIB YP_001746589.1 4766175 D 439855 CDS YP_001746590.1 170679597 6143461 4766490..4766954 1 NC_010498.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4766954 ulaC 6143461 ulaC Escherichia coli SMS-3-5 PTS system L-ascorbate-specific transporter subunit IIA YP_001746590.1 4766490 D 439855 CDS YP_001746591.1 170680232 6143754 4766968..4767618 1 NC_010498.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4767618 ulaD 6143754 ulaD Escherichia coli SMS-3-5 3-keto-L-gulonate-6-phosphate decarboxylase YP_001746591.1 4766968 D 439855 CDS YP_001746592.1 170680928 6144398 4767628..4768482 1 NC_010498.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4768482 ulaE 6144398 ulaE Escherichia coli SMS-3-5 L-xylulose 5-phosphate 3-epimerase YP_001746592.1 4767628 D 439855 CDS YP_001746593.1 170681480 6145109 4768482..4769168 1 NC_010498.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4769168 sgaE 6145109 sgaE Escherichia coli SMS-3-5 L-ribulose-5-phosphate 4-epimerase YP_001746593.1 4768482 D 439855 CDS YP_001746594.1 170683813 6145665 complement(4769297..4769572) 1 NC_010498.1 identified by match to protein family HMM PF07338; hypothetical protein 4769572 6145665 EcSMS35_4670 Escherichia coli SMS-3-5 hypothetical protein YP_001746594.1 4769297 R 439855 CDS YP_001746595.1 170682447 6143107 4769900..4770295 1 NC_010498.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4770295 rpsF 6143107 rpsF Escherichia coli SMS-3-5 30S ribosomal protein S6 YP_001746595.1 4769900 D 439855 CDS YP_001746596.1 170680020 6146646 4770621..4770848 1 NC_010498.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4770848 rpsR 6146646 rpsR Escherichia coli SMS-3-5 30S ribosomal protein S18 YP_001746596.1 4770621 D 439855 CDS YP_001746597.1 170680673 6144183 4770890..4771339 1 NC_010498.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4771339 rplI 6144183 rplI Escherichia coli SMS-3-5 50S ribosomal protein L9 YP_001746597.1 4770890 D 439855 CDS YP_001746598.1 170681376 6144848 complement(4771451..4772422) 1 NC_010498.1 identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein 4772422 6144848 EcSMS35_4674 Escherichia coli SMS-3-5 TRAP transporter solute receptor DctP family protein YP_001746598.1 4771451 R 439855 CDS YP_001746599.1 170679845 6145560 complement(4772475..4773776) 1 NC_010498.1 identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter, DctM subunit 4773776 6145560 EcSMS35_4675 Escherichia coli SMS-3-5 TRAP transporter, DctM subunit YP_001746599.1 4772475 R 439855 CDS YP_001746600.1 170680904 6144007 complement(4773819..4774295) 1 NC_010498.1 identified by match to protein family HMM PF04290; TRAP transporter, DctQ-like membrane protein 4774295 6144007 EcSMS35_4676 Escherichia coli SMS-3-5 TRAP transporter, DctQ-like membrane protein YP_001746600.1 4773819 R 439855 CDS YP_001746601.1 170681538 6145083 complement(4774316..4776397) 1 NC_010498.1 identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF07992; pyridine nucleotide-disulphide oxidoreductase 4776397 6145083 EcSMS35_4677 Escherichia coli SMS-3-5 pyridine nucleotide-disulphide oxidoreductase YP_001746601.1 4774316 R 439855 CDS YP_001746602.1 170684002 6145723 complement(4776394..4777935) 1 NC_010498.1 identified by match to protein family HMM PF01144; CoA-transferase 4777935 6145723 EcSMS35_4678 Escherichia coli SMS-3-5 CoA-transferase YP_001746602.1 4776394 R 439855 CDS YP_001746603.1 170682441 6143301 complement(4777945..4778721) 1 NC_010498.1 identified by match to protein family HMM PF00378; enoyl-CoA hydratase/isomerase family protein 4778721 6143301 EcSMS35_4679 Escherichia coli SMS-3-5 enoyl-CoA hydratase/isomerase family protein YP_001746603.1 4777945 R 439855 CDS YP_001746604.1 170681633 6146640 complement(4778731..4779573) 1 NC_010498.1 identified by match to protein family HMM PF01261; AP endonuclease 4779573 6146640 EcSMS35_4680 Escherichia coli SMS-3-5 AP endonuclease YP_001746604.1 4778731 R 439855 CDS YP_001746605.1 170680045 6145818 complement(4779583..4780374) 1 NC_010498.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 4780374 6145818 EcSMS35_4681 Escherichia coli SMS-3-5 3-ketoacyl-(acyl-carrier-protein) reductase YP_001746605.1 4779583 R 439855 CDS YP_001746606.1 170681145 6144208 4780584..4781222 1 NC_010498.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 4781222 6144208 EcSMS35_4682 Escherichia coli SMS-3-5 TetR family transcriptional regulator YP_001746606.1 4780584 D 439855 CDS YP_001746607.1 170681738 6145328 complement(4781223..4781852) 1 NC_010498.1 identified by match to protein family HMM PF04225; match to protein family HMM PF08525; opacity-associated family protein 4781852 6145328 EcSMS35_4683 Escherichia coli SMS-3-5 opacity-associated family protein YP_001746607.1 4781223 R 439855 CDS YP_001746608.1 170682131 6145927 4782070..4782690 1 NC_010498.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4782690 fklB 6145927 fklB Escherichia coli SMS-3-5 peptidyl-prolyl cis-trans isomerase YP_001746608.1 4782070 D 439855 CDS YP_001746609.1 170682794 6146330 4782999..4784402 1 NC_010498.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4784402 cycA 6146330 cycA Escherichia coli SMS-3-5 D-alanine/D-serine/glycine permease YP_001746609.1 4782999 D 439855 CDS YP_001746610.1 170683978 6147003 4784536..4785693 1 NC_010498.1 identified by similarity to GB:CAD06876.1; hypothetical protein 4785693 6147003 EcSMS35_4686 Escherichia coli SMS-3-5 hypothetical protein YP_001746610.1 4784536 D 439855 CDS YP_001746611.1 170682000 6143275 4785726..4787219 1 NC_010498.1 identified by similarity to GB:CAD06877.1; hypothetical protein 4787219 6143275 EcSMS35_4687 Escherichia coli SMS-3-5 hypothetical protein YP_001746611.1 4785726 D 439855 CDS YP_001746612.1 170680284 6146196 complement(4787264..4787926) 1 NC_010498.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4787926 6146196 EcSMS35_4688 Escherichia coli SMS-3-5 iron-sulfur cluster repair di-iron protein YP_001746612.1 4787264 R 439855 CDS YP_001746613.1 170680592 6144451 complement(4788034..4788999) 1 NC_010498.1 identified by match to protein family HMM PF00892; hypothetical protein 4788999 6144451 EcSMS35_4689 Escherichia coli SMS-3-5 hypothetical protein YP_001746613.1 4788034 R 439855 CDS YP_001746614.1 170683021 6144764 complement(4789107..4789967) 1 NC_010498.1 identified by match to protein family HMM PF01073; match to protein family HMM PF05368; NmrA family protein 4789967 6144764 EcSMS35_4690 Escherichia coli SMS-3-5 NmrA family protein YP_001746614.1 4789107 R 439855 CDS YP_001746615.1 170681160 6147237 4790056..4790436 1 NC_010498.1 identified by match to protein family HMM PF01638; putative transcriptional regulator 4790436 6147237 EcSMS35_4691 Escherichia coli SMS-3-5 putative transcriptional regulator YP_001746615.1 4790056 D 439855 CDS YP_001746616.1 170683745 6145344 complement(4790565..4792508) 1 NC_010498.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein 4792508 cpdB 6145344 cpdB Escherichia coli SMS-3-5 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein YP_001746616.1 4790565 R 439855 CDS YP_001746617.1 170680311 6143037 4792698..4793438 1 NC_010498.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4793438 cysQ 6143037 cysQ Escherichia coli SMS-3-5 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_001746617.1 4792698 D 439855 CDS YP_001746618.1 170682505 6144479 complement(4793428..4793985) 1 NC_010498.1 identified by match to protein family HMM TIGR01626; hypothetical protein 4793985 6144479 EcSMS35_4693 Escherichia coli SMS-3-5 hypothetical protein YP_001746618.1 4793428 R 439855 CDS YP_001746619.1 170683186 6146705 4794310..4794516 1 NC_010498.1 identified by match to protein family HMM PF06526; hypothetical protein 4794516 6146705 EcSMS35_4695 Escherichia coli SMS-3-5 hypothetical protein YP_001746619.1 4794310 D 439855 CDS YP_001746620.1 170679891 6147406 complement(4794578..4795921) 1 NC_010498.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; putative transporter 4795921 6147406 EcSMS35_4696 Escherichia coli SMS-3-5 putative transporter YP_001746620.1 4794578 R 439855 CDS YP_001746621.1 170679826 6144053 complement(4796244..4796882) 1 NC_010498.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4796882 msrA 6144053 msrA Escherichia coli SMS-3-5 methionine sulfoxide reductase A YP_001746621.1 4796244 R 439855 CDS YP_001746622.1 170681255 6143988 4796990..4797118 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4797118 6143988 EcSMS35_4698 Escherichia coli SMS-3-5 hypothetical protein YP_001746622.1 4796990 D 439855 CDS YP_001746623.1 170681698 6145439 4797088..4798821 1 NC_010498.1 identified by match to protein family HMM PF01103; match to protein family HMM PF07244; OMP85 family outer membrane protein 4798821 6145439 EcSMS35_4699 Escherichia coli SMS-3-5 OMP85 family outer membrane protein YP_001746623.1 4797088 D 439855 CDS YP_001746624.1 170683277 6145884 4798818..4802597 1 NC_010498.1 identified by match to protein family HMM PF04357; hypothetical protein 4802597 6145884 EcSMS35_4700 Escherichia coli SMS-3-5 hypothetical protein YP_001746624.1 4798818 D 439855 CDS YP_001746625.1 170682937 6147503 4802600..4802941 1 NC_010498.1 identified by match to protein family HMM PF03674; hypothetical protein 4802941 6147503 EcSMS35_4701 Escherichia coli SMS-3-5 hypothetical protein YP_001746625.1 4802600 D 439855 CDS YP_001746626.1 170679904 6147151 4803153..4803404 1 NC_010498.1 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4803404 chpS 6147151 chpS Escherichia coli SMS-3-5 antitoxin ChpS YP_001746626.1 4803153 D 439855 CDS YP_001746627.1 170684198 6144066 4803398..4803748 1 NC_010498.1 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4803748 chpB 6144066 chpB Escherichia coli SMS-3-5 toxin ChpB YP_001746627.1 4803398 D 439855 CDS YP_001746628.1 170680243 6143499 complement(4803827..4804357) 1 NC_010498.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4804357 ppa 6143499 ppa Escherichia coli SMS-3-5 inorganic pyrophosphatase YP_001746628.1 4803827 R 439855 CDS YP_001746629.1 170679669 6144410 4804667..4805623 1 NC_010498.1 identified by match to protein family HMM PF00532; putative sugar ABC transporter periplasmic sugar-binding protein 4805623 6144410 EcSMS35_4705 Escherichia coli SMS-3-5 putative sugar ABC transporter periplasmic sugar-binding protein YP_001746629.1 4804667 D 439855 CDS YP_001746630.1 170681344 6143827 4805756..4807258 1 NC_010498.1 identified by match to protein family HMM PF00005; putative sugar ABC transporter ATP-binding protein 4807258 6143827 EcSMS35_4706 Escherichia coli SMS-3-5 putative sugar ABC transporter ATP-binding protein YP_001746630.1 4805756 D 439855 CDS YP_001746631.1 170680997 6145528 4807272..4808294 1 NC_010498.1 identified by match to protein family HMM PF02653; putative sugar ABC transporter permease 4808294 6145528 EcSMS35_4707 Escherichia coli SMS-3-5 putative sugar ABC transporter permease YP_001746631.1 4807272 D 439855 CDS YP_001746632.1 170682693 6145178 4808281..4809276 1 NC_010498.1 membrane component of a putative sugar ABC transporter system; inner membrane ABC transporter permease YjfF 4809276 6145178 EcSMS35_4708 Escherichia coli SMS-3-5 inner membrane ABC transporter permease YjfF YP_001746632.1 4808281 D 439855 CDS YP_001746633.1 170682271 6146901 complement(4809309..4810307) 1 NC_010498.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4810307 fbp 6146901 fbp Escherichia coli SMS-3-5 fructose-1,6-bisphosphatase YP_001746633.1 4809309 R 439855 CDS YP_001746634.1 170681834 6146470 4810370..4810501 1 NC_010498.1 hypothetical protein 4810501 6146470 EcSMS35_4710 Escherichia coli SMS-3-5 hypothetical protein YP_001746634.1 4810370 D 439855 CDS YP_001746635.1 170681037 6146027 4810483..4811856 1 NC_010498.1 identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01081; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4811856 mpl 6146027 mpl Escherichia coli SMS-3-5 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_001746635.1 4810483 D 439855 CDS YP_001746636.1 170680638 6145218 complement(4811939..4812490) 1 NC_010498.1 yjgA; identified by match to protein family HMM PF04751; hypothetical protein 4812490 yjgA 6145218 yjgA Escherichia coli SMS-3-5 hypothetical protein YP_001746636.1 4811939 R 439855 CDS YP_001746637.1 170681431 6144813 4812584..4813936 1 NC_010498.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4813936 pmbA 6144813 pmbA Escherichia coli SMS-3-5 peptidase PmbA YP_001746637.1 4812584 D 439855 CDS YP_001746638.1 170683137 6145615 4813992..4814378 1 NC_010498.1 identified by match to protein family HMM PF07361; soluble cytochrome b562 4814378 cybC 6145615 cybC Escherichia coli SMS-3-5 soluble cytochrome b562 YP_001746638.1 4813992 D 439855 CDS YP_001746639.1 170680389 6147356 4814570..4814812 1 NC_010498.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 4814812 relB 6147356 relB Escherichia coli SMS-3-5 bifunctional antitoxin/transcriptional repressor RelB YP_001746639.1 4814570 D 439855 CDS YP_001746640.1 170682401 6144558 4814802..4815092 1 NC_010498.1 identified by similarity to SP:P0C077; match to protein family HMM PF05016; match to protein family HMM TIGR02385; addiction module toxin RelE 4815092 relE 6144558 relE Escherichia coli SMS-3-5 addiction module toxin RelE YP_001746640.1 4814802 D 439855 CDS YP_001746641.1 170684257 6146600 complement(4815093..4815557) 1 NC_010498.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4815557 nrdG 6146600 nrdG Escherichia coli SMS-3-5 anaerobic ribonucleotide reductase-activating protein YP_001746641.1 4815093 R 439855 CDS YP_001746642.1 170681280 6143559 complement(4815742..4817880) 1 NC_010498.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4817880 nrdD 6143559 nrdD Escherichia coli SMS-3-5 anaerobic ribonucleoside triphosphate reductase YP_001746642.1 4815742 R 439855 CDS YP_001746643.1 170682903 6145464 4817920..4818042 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4818042 6145464 EcSMS35_4719 Escherichia coli SMS-3-5 hypothetical protein YP_001746643.1 4817920 D 439855 CDS YP_001746644.1 170682699 6147116 complement(4818274..4819929) 1 NC_010498.1 identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; trehalose-6-phosphate hydrolase 4819929 treC 6147116 treC Escherichia coli SMS-3-5 trehalose-6-phosphate hydrolase YP_001746644.1 4818274 R 439855 CDS YP_001746645.1 170682939 6146907 complement(4819979..4821400) 1 NC_010498.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC 4821400 treB 6146907 treB Escherichia coli SMS-3-5 PTS system trehalose(maltose)-specific transporter subunits IIBC YP_001746645.1 4819979 R 439855 CDS YP_001746646.1 170680573 6147153 complement(4821519..4822466) 1 NC_010498.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4822466 treR 6147153 treR Escherichia coli SMS-3-5 trehalose repressor YP_001746646.1 4821519 R 439855 CDS YP_001746647.1 170683625 6144743 4822845..4825541 1 NC_010498.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4825541 mgtA 6144743 mgtA Escherichia coli SMS-3-5 magnesium-transporting ATPase MgtA YP_001746647.1 4822845 D 439855 CDS YP_001746648.1 170684125 6142916 complement(4825747..4826172) 1 NC_010498.1 identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; putative endoribonuclease L-PSP 4826172 6142916 EcSMS35_4724 Escherichia coli SMS-3-5 putative endoribonuclease L-PSP YP_001746648.1 4825747 R 439855 CDS YP_001746649.1 170682294 6143425 complement(4826206..4826667) 1 NC_010498.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 4826667 pyrI 6143425 pyrI Escherichia coli SMS-3-5 aspartate carbamoyltransferase regulatory subunit YP_001746649.1 4826206 R 439855 CDS YP_001746650.1 170680939 6146493 complement(4826680..4827615) 1 NC_010498.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4827615 pyrB 6146493 pyrB Escherichia coli SMS-3-5 aspartate carbamoyltransferase catalytic subunit YP_001746650.1 4826680 R 439855 CDS YP_001746651.1 170681083 6145120 complement(4827786..4827929) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4827929 6145120 EcSMS35_4727 Escherichia coli SMS-3-5 hypothetical protein YP_001746651.1 4827786 R 439855 CDS YP_001746652.1 170679593 6145265 complement(4828034..4828429) 1 NC_010498.1 identified by match to protein family HMM PF01042; endoribonuclease L-PSP family protein 4828429 6145265 EcSMS35_4728 Escherichia coli SMS-3-5 endoribonuclease L-PSP family protein YP_001746652.1 4828034 R 439855 CDS YP_001746653.1 170680357 6143750 complement(4828561..4829274) 1 NC_010498.1 identified by match to protein family HMM PF00106; oxidoreductase 4829274 6143750 EcSMS35_4729 Escherichia coli SMS-3-5 oxidoreductase YP_001746653.1 4828561 R 439855 CDS YP_001746654.1 170683046 6144525 4829345..4829938 1 NC_010498.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 4829938 6144525 EcSMS35_4730 Escherichia coli SMS-3-5 TetR family transcriptional regulator YP_001746654.1 4829345 D 439855 CDS YP_001746655.1 170681188 6147262 4829938..4830066 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4830066 6147262 EcSMS35_4731 Escherichia coli SMS-3-5 hypothetical protein YP_001746655.1 4829938 D 439855 CDS YP_001746656.1 170681395 6145372 4830083..4830535 1 NC_010498.1 yjgK; identified by similarity to SP:P0AF97; match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 4830535 6145372 EcSMS35_4732 Escherichia coli SMS-3-5 hypothetical protein YP_001746656.1 4830083 D 439855 CDS YP_001746657.1 170683240 6144756 complement(4832383..4833387) 1 NC_010498.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4833387 argF 6144756 argF Escherichia coli SMS-3-5 ornithine carbamoyltransferase subunit I YP_001746657.1 4832383 R 439855 CDS YP_001746658.1 170683421 6147462 4833549..4833965 1 NC_010498.1 identified by match to protein family HMM PF06877; hypothetical protein 4833965 6147462 EcSMS35_4735 Escherichia coli SMS-3-5 hypothetical protein YP_001746658.1 4833549 D 439855 CDS YP_001746659.1 170684114 6142708 complement(4834011..4834514) 1 NC_010498.1 identified by match to protein family HMM PF00583; acetyltransferase 4834514 6142708 EcSMS35_4736 Escherichia coli SMS-3-5 acetyltransferase YP_001746659.1 4834011 R 439855 CDS YP_001746660.1 170682446 6143414 4834680..4835903 1 NC_010498.1 identified by match to protein family HMM PF05987; hypothetical protein 4835903 6143414 EcSMS35_4737 Escherichia coli SMS-3-5 hypothetical protein YP_001746660.1 4834680 D 439855 CDS YP_001746661.1 170683054 6146645 complement(4835957..4838812) 1 NC_010498.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4838812 valS 6146645 valS Escherichia coli SMS-3-5 valyl-tRNA synthetase YP_001746661.1 4835957 R 439855 CDS YP_001746662.1 170683022 6147270 complement(4838812..4839294) 1 NC_010498.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4839294 holC 6147270 holC Escherichia coli SMS-3-5 DNA polymerase III subunit chi YP_001746662.1 4838812 R 439855 CDS YP_001746663.1 170681979 6147238 complement(4839389..4840900) 1 NC_010498.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4840900 pepA 6147238 pepA Escherichia coli SMS-3-5 leucyl aminopeptidase YP_001746663.1 4839389 R 439855 CDS YP_001746664.1 170682159 6146175 complement(4841125..4841253) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4841253 6146175 EcSMS35_4741 Escherichia coli SMS-3-5 hypothetical protein YP_001746664.1 4841125 R 439855 CDS YP_001746665.1 170681521 6146358 4841167..4842267 1 NC_010498.1 identified by match to protein family HMM PF03739; putative permease 4842267 6146358 EcSMS35_4742 Escherichia coli SMS-3-5 putative permease YP_001746665.1 4841167 D 439855 CDS YP_001746666.1 170681768 6145706 4842267..4843349 1 NC_010498.1 identified by match to protein family HMM PF03739; putative permease 4843349 6145706 EcSMS35_4743 Escherichia coli SMS-3-5 putative permease YP_001746666.1 4842267 D 439855 CDS YP_001746667.1 170681088 6145960 complement(4843468..4844970) 1 NC_010498.1 identified by match to protein family HMM PF05872; hypothetical protein 4844970 6145960 EcSMS35_4744 Escherichia coli SMS-3-5 hypothetical protein YP_001746667.1 4843468 R 439855 CDS YP_001746668.1 170679936 6145270 complement(4845048..4846046) 1 NC_010498.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator IdnR 4846046 idnR 6145270 idnR Escherichia coli SMS-3-5 transcriptional regulator IdnR YP_001746668.1 4845048 R 439855 CDS YP_001746669.1 170684304 6144098 complement(4846113..4847432) 1 NC_010498.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM PF06808; match to protein family HMM TIGR00791; Gnt-II system L-idonate transporter 4847432 idnT 6144098 idnT Escherichia coli SMS-3-5 Gnt-II system L-idonate transporter YP_001746669.1 4846113 R 439855 CDS YP_001746670.1 170683616 6143606 complement(4847497..4848261) 1 NC_010498.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 4848261 idnO 6143606 idnO Escherichia coli SMS-3-5 gluconate 5-dehydrogenase YP_001746670.1 4847497 R 439855 CDS YP_001746671.1 170683029 6142906 complement(4848285..4849316) 1 NC_010498.1 NAD-binding; L-idonate 5-dehydrogenase 4849316 idnD 6142906 idnD Escherichia coli SMS-3-5 L-idonate 5-dehydrogenase YP_001746671.1 4848285 R 439855 CDS YP_001746672.1 170683870 6147245 4849533..4850096 1 NC_010498.1 identified by match to protein family HMM PF01202; match to protein family HMM TIGR01313; D-gluconate kinase 4850096 idnK 6147245 idnK Escherichia coli SMS-3-5 D-gluconate kinase YP_001746672.1 4849533 D 439855 CDS YP_001746673.1 170683328 6143165 complement(4850100..4851119) 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 4851119 6143165 EcSMS35_4750 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001746673.1 4850100 R 439855 CDS YP_001746674.1 170682520 6143639 4851586..4852851 1 NC_010498.1 identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 4852851 6143639 EcSMS35_4753 Escherichia coli SMS-3-5 phage integrase family site specific recombinase YP_001746674.1 4851586 D 439855 CDS YP_001746675.1 170681302 6146721 complement(4853175..4854674) 1 NC_010498.1 yjgX; identified by match to protein family HMM PF00884; sulfatase family protein 4854674 6146721 EcSMS35_4754 Escherichia coli SMS-3-5 sulfatase family protein YP_001746675.1 4853175 R 439855 CDS YP_001746676.1 170680671 6145486 complement(4854848..4855639) 1 NC_010498.1 identified by similarity to GB:AAC13751.1; match to protein family HMM PF01389; match to protein family HMM PF01617; heat resistant agglutinin 1 4855639 6145486 EcSMS35_4755 Escherichia coli SMS-3-5 heat resistant agglutinin 1 YP_001746676.1 4854848 R 439855 CDS YP_001746677.1 170683922 6144163 complement(4856011..4856514) 1 NC_010498.1 identified by match to protein family HMM PF03400; IS1 transposase orfB 4856514 6144163 EcSMS35_4757 Escherichia coli SMS-3-5 IS1 transposase orfB YP_001746677.1 4856011 R 439855 CDS YP_001746678.1 170684253 6143218 complement(4856525..4856737) 1 NC_010498.1 IS1 transposase orfA 4856737 6143218 EcSMS35_4758 Escherichia coli SMS-3-5 IS1 transposase orfA YP_001746678.1 4856525 R 439855 CDS YP_001746679.1 170679881 6143555 4856981..4857478 1 NC_010498.1 identified by match to protein family HMM PF04221; addiction module antitoxin 4857478 6143555 EcSMS35_4759 Escherichia coli SMS-3-5 addiction module antitoxin YP_001746679.1 4856981 D 439855 CDS YP_001746680.1 170683208 6144043 4857545..4859524 1 NC_010498.1 identified by match to protein family HMM PF02384; type I restriction-modification system DNA methylase 4859524 6144043 EcSMS35_4760 Escherichia coli SMS-3-5 type I restriction-modification system DNA methylase YP_001746680.1 4857545 D 439855 CDS YP_001746681.1 170680371 6147429 4859524..4860810 1 NC_010498.1 identified by match to protein family HMM PF01420; type I restriction modification DNA specificity domain-containing protein 4860810 6147429 EcSMS35_4761 Escherichia coli SMS-3-5 type I restriction modification DNA specificity domain-containing protein YP_001746681.1 4859524 D 439855 CDS YP_001746682.1 170682576 6144539 4860810..4864046 1 NC_010498.1 identified by match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system endonuclease 4864046 6144539 EcSMS35_4762 Escherichia coli SMS-3-5 type I restriction-modification system endonuclease YP_001746682.1 4860810 D 439855 CDS YP_001746683.1 170682046 6146781 4864046..4864600 1 NC_010498.1 identified by similarity to GB:AAW89424.1; hypothetical protein 4864600 6146781 EcSMS35_4763 Escherichia coli SMS-3-5 hypothetical protein YP_001746683.1 4864046 D 439855 CDS YP_001746684.1 170681728 6146243 4864603..4865442 1 NC_010498.1 identified by similarity to GB:AAW89425.1; hypothetical protein 4865442 6146243 EcSMS35_4764 Escherichia coli SMS-3-5 hypothetical protein YP_001746684.1 4864603 D 439855 CDS YP_001746685.1 170680748 6145916 4865478..4866512 1 NC_010498.1 identified by similarity to GB:AAL22613.1; hypothetical protein 4866512 6145916 EcSMS35_4765 Escherichia coli SMS-3-5 hypothetical protein YP_001746685.1 4865478 D 439855 CDS YP_001746686.1 170681008 6144923 complement(4866570..4866956) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4866956 6144923 EcSMS35_4766 Escherichia coli SMS-3-5 hypothetical protein YP_001746686.1 4866570 R 439855 CDS YP_001746687.1 170681450 6145189 complement(4867046..4867246) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4867246 6145189 EcSMS35_4767 Escherichia coli SMS-3-5 hypothetical protein YP_001746687.1 4867046 R 439855 CDS YP_001746688.1 170679584 6145635 4867751..4868083 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4868083 6145635 EcSMS35_4768 Escherichia coli SMS-3-5 hypothetical protein YP_001746688.1 4867751 D 439855 CDS YP_001746689.1 170679817 6142705 complement(4869080..4869703) 1 NC_010498.1 identified by similarity to GB:AAT68662.1; hypothetical protein 4869703 6142705 EcSMS35_4770 Escherichia coli SMS-3-5 hypothetical protein YP_001746689.1 4869080 R 439855 CDS YP_001746690.1 170680174 6143978 complement(4869886..4870776) 1 NC_010498.1 identified by match to protein family HMM PF00665; IS1203 transposase orfB 4870776 6143978 EcSMS35_4771 Escherichia coli SMS-3-5 IS1203 transposase orfB YP_001746690.1 4869886 R 439855 CDS YP_001746691.1 170683505 6144340 complement(4870757..4871098) 1 NC_010498.1 identified by match to protein family HMM PF01527; IS1203 transposase orfA 4871098 6144340 EcSMS35_4772 Escherichia coli SMS-3-5 IS1203 transposase orfA YP_001746691.1 4870757 R 439855 CDS YP_001746692.1 170682651 6142794 complement(4871104..4871403) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4871403 6142794 EcSMS35_4773 Escherichia coli SMS-3-5 hypothetical protein YP_001746692.1 4871104 R 439855 CDS YP_001746693.1 170682470 6147013 complement(4871735..4872100) 1 NC_010498.1 hypothetical protein 4872100 6147013 EcSMS35_4775 Escherichia coli SMS-3-5 hypothetical protein YP_001746693.1 4871735 R 439855 CDS YP_001746694.1 170682497 6146669 4872207..4873415 1 NC_010498.1 identified by match to protein family HMM PF01609; IS10 transposase 4873415 6146669 EcSMS35_4777 Escherichia coli SMS-3-5 IS10 transposase YP_001746694.1 4872207 D 439855 CDS YP_001746695.1 170682988 6146697 complement(4873394..4874056) 1 NC_010498.1 identified by similarity to GB:AAM31897.1; hypothetical protein 4874056 6146697 EcSMS35_4776 Escherichia coli SMS-3-5 hypothetical protein YP_001746695.1 4873394 R 439855 CDS YP_001746696.1 170681932 6147204 complement(4874066..4874674) 1 NC_010498.1 identified by similarity to GB:ABE29579.1; hypothetical protein 4874674 6147204 EcSMS35_4778 Escherichia coli SMS-3-5 hypothetical protein YP_001746696.1 4874066 R 439855 CDS YP_001746697.1 170680160 6143278 complement(4875264..4875776) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4875776 6143278 EcSMS35_4780 Escherichia coli SMS-3-5 hypothetical protein YP_001746697.1 4875264 R 439855 CDS YP_001746698.1 170683000 6144326 complement(4875858..4875995) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4875995 6144326 EcSMS35_4781 Escherichia coli SMS-3-5 hypothetical protein YP_001746698.1 4875858 R 439855 CDS YP_001746699.1 170680125 6147216 complement(4876033..4876266) 1 NC_010498.1 identified by match to protein family HMM PF05930; AlpA family transcriptional regulator 4876266 6147216 EcSMS35_4782 Escherichia coli SMS-3-5 AlpA family transcriptional regulator YP_001746699.1 4876033 R 439855 CDS YP_001746700.1 170684061 6144290 complement(4876335..4876910) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4876910 6144290 EcSMS35_4783 Escherichia coli SMS-3-5 hypothetical protein YP_001746700.1 4876335 R 439855 CDS YP_001746701.1 170681169 6143360 complement(4877157..4877723) 1 NC_010498.1 identified by similarity to GB:CAG75762.1; hypothetical protein 4877723 6143360 EcSMS35_4784 Escherichia coli SMS-3-5 hypothetical protein YP_001746701.1 4877157 R 439855 CDS YP_001746702.1 170681700 6147488 complement(4879662..4880102) 1 NC_010498.1 identified by match to protein family HMM PF00816; H-NS histone family protein 4880102 6147488 EcSMS35_4786 Escherichia coli SMS-3-5 H-NS histone family protein YP_001746702.1 4879662 R 439855 CDS YP_001746703.1 170683471 6143468 complement(4881859..4882557) 1 NC_010498.1 identified by similarity to GB:ABB74995.1; hypothetical protein 4882557 6143468 EcSMS35_4789 Escherichia coli SMS-3-5 hypothetical protein YP_001746703.1 4881859 R 439855 CDS YP_001746704.1 170679889 6142760 4882614..4882940 1 NC_010498.1 IS1203 transposase orfA 4882940 6142760 EcSMS35_4790 Escherichia coli SMS-3-5 IS1203 transposase orfA YP_001746704.1 4882614 D 439855 CDS YP_001746705.1 170679822 6144051 4882937..4883827 1 NC_010498.1 identified by match to protein family HMM PF00665; IS1203 transposase orfB 4883827 6144051 EcSMS35_4791 Escherichia coli SMS-3-5 IS1203 transposase orfB YP_001746705.1 4882937 D 439855 CDS YP_001746706.1 170681456 6143984 complement(4884268..4884381) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4884381 6143984 EcSMS35_4792 Escherichia coli SMS-3-5 hypothetical protein YP_001746706.1 4884268 R 439855 CDS YP_001746707.1 170680816 6145641 complement(4884378..4885109) 1 NC_010498.1 hypothetical protein 4885109 6145641 EcSMS35_4793 Escherichia coli SMS-3-5 hypothetical protein YP_001746707.1 4884378 R 439855 CDS YP_001746708.1 170681021 6144992 4885293..4885445 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4885445 6144992 EcSMS35_4794 Escherichia coli SMS-3-5 hypothetical protein YP_001746708.1 4885293 D 439855 CDS YP_001746709.1 170680217 6145202 complement(4886588..4887718) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4887718 6145202 EcSMS35_4795 Escherichia coli SMS-3-5 hypothetical protein YP_001746709.1 4886588 R 439855 CDS YP_001746710.1 170681962 6144383 complement(4887775..4887909) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4887909 6144383 EcSMS35_4796 Escherichia coli SMS-3-5 hypothetical protein YP_001746710.1 4887775 R 439855 CDS YP_001746711.1 170679951 6146158 4887903..4888787 1 NC_010498.1 identified by match to protein family HMM PF01926; putative GTPase 4888787 6146158 EcSMS35_4797 Escherichia coli SMS-3-5 putative GTPase YP_001746711.1 4887903 D 439855 CDS YP_001746712.1 170681804 6144113 4888806..4888961 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4888961 6144113 EcSMS35_4798 Escherichia coli SMS-3-5 hypothetical protein YP_001746712.1 4888806 D 439855 CDS YP_001746713.1 170681210 6145997 4888990..4889670 1 NC_010498.1 identified by match to protein family HMM PF08279; hypothetical protein 4889670 6145997 EcSMS35_4799 Escherichia coli SMS-3-5 hypothetical protein YP_001746713.1 4888990 D 439855 CDS YP_001746714.1 170682078 6145394 4889713..4890495 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4890495 6145394 EcSMS35_4800 Escherichia coli SMS-3-5 hypothetical protein YP_001746714.1 4889713 D 439855 CDS YP_001746715.1 170681440 6146275 4890585..4890734 1 NC_010498.1 hypothetical protein 4890734 6146275 EcSMS35_4801 Escherichia coli SMS-3-5 hypothetical protein YP_001746715.1 4890585 D 439855 CDS YP_001746716.1 170683409 6145624 4890824..4891642 1 NC_010498.1 yafZ; identified by match to protein family HMM PF06067; hypothetical protein 4891642 6145624 EcSMS35_4802 Escherichia coli SMS-3-5 hypothetical protein YP_001746716.1 4890824 D 439855 CDS YP_001746717.1 170682800 6142695 4891734..4892219 1 NC_010498.1 identified by match to protein family HMM PF03230; antirestriction protein 4892219 6142695 EcSMS35_4803 Escherichia coli SMS-3-5 antirestriction protein YP_001746717.1 4891734 D 439855 CDS YP_001746718.1 170680679 6147010 4892234..4892710 1 NC_010498.1 identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 4892710 6147010 EcSMS35_4804 Escherichia coli SMS-3-5 RadC family DNA repair protein YP_001746718.1 4892234 D 439855 CDS YP_001746719.1 170680745 6144854 4892797..4893018 1 NC_010498.1 identified by match to protein family HMM PF06174; hypothetical protein 4893018 6144854 EcSMS35_4805 Escherichia coli SMS-3-5 hypothetical protein YP_001746719.1 4892797 D 439855 CDS YP_001746720.1 170681653 6144920 4893218..4893466 1 NC_010498.1 identified by match to protein family HMM PF06154; hypothetical protein 4893466 6144920 EcSMS35_4806 Escherichia coli SMS-3-5 hypothetical protein YP_001746720.1 4893218 D 439855 CDS YP_001746721.1 170683261 6145839 4893556..4893933 1 NC_010498.1 identified by match to protein family HMM PF06755; hypothetical protein 4893933 6145839 EcSMS35_4807 Escherichia coli SMS-3-5 hypothetical protein YP_001746721.1 4893556 D 439855 CDS YP_001746722.1 170680554 6147484 4893930..4894418 1 NC_010498.1 hypothetical protein 4894418 6147484 EcSMS35_4808 Escherichia coli SMS-3-5 hypothetical protein YP_001746722.1 4893930 D 439855 CDS YP_001746723.1 170679806 6144724 4894438..4894635 1 NC_010498.1 identified by match to protein family HMM PF06117; hypothetical protein 4894635 6144724 EcSMS35_4809 Escherichia coli SMS-3-5 hypothetical protein YP_001746723.1 4894438 D 439855 CDS YP_001746724.1 170682527 6145958 complement(4896629..4897522) 1 NC_010498.1 hypothetical protein 4897522 6145958 EcSMS35_4812 Escherichia coli SMS-3-5 hypothetical protein YP_001746724.1 4896629 R 439855 CDS YP_001746725.1 170683076 6146728 4897698..4899164 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4899164 6146728 EcSMS35_4813 Escherichia coli SMS-3-5 hypothetical protein YP_001746725.1 4897698 D 439855 CDS YP_001746726.1 170683503 6147293 4899167..4900063 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4900063 6147293 EcSMS35_4814 Escherichia coli SMS-3-5 hypothetical protein YP_001746726.1 4899167 D 439855 CDS YP_001746727.1 170680404 6142792 4900066..4904502 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4904502 6142792 EcSMS35_4815 Escherichia coli SMS-3-5 hypothetical protein YP_001746727.1 4900066 D 439855 CDS YP_001746728.1 170679940 6144573 4904515..4905570 1 NC_010498.1 hypothetical protein 4905570 6144573 EcSMS35_4816 Escherichia coli SMS-3-5 hypothetical protein YP_001746728.1 4904515 D 439855 CDS YP_001746729.1 170683097 6144102 4905697..4906695 1 NC_010498.1 hypothetical protein 4906695 6144102 EcSMS35_4817 Escherichia coli SMS-3-5 hypothetical protein YP_001746729.1 4905697 D 439855 CDS YP_001746730.1 170683509 6147316 complement(4906807..4907679) 1 NC_010498.1 hypothetical protein 4907679 6147316 EcSMS35_4818 Escherichia coli SMS-3-5 hypothetical protein YP_001746730.1 4906807 R 439855 CDS YP_001746731.1 170684021 6142798 4907642..4907764 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4907764 6142798 EcSMS35_4819 Escherichia coli SMS-3-5 hypothetical protein YP_001746731.1 4907642 D 439855 CDS YP_001746732.1 170679831 6143320 4907816..4908457 1 NC_010498.1 identified by match to protein family HMM PF01844; HNH endonuclease domain-containing protein 4908457 6143320 EcSMS35_4820 Escherichia coli SMS-3-5 HNH endonuclease domain-containing protein YP_001746732.1 4907816 D 439855 CDS YP_001746733.1 170681364 6145041 complement(4909284..4910387) 1 NC_010498.1 hypothetical protein 4910387 6145041 EcSMS35_4822 Escherichia coli SMS-3-5 hypothetical protein YP_001746733.1 4909284 R 439855 CDS YP_001746734.1 170680753 6145548 complement(4910391..4911098) 1 NC_010498.1 hypothetical protein 4911098 6145548 EcSMS35_4823 Escherichia coli SMS-3-5 hypothetical protein YP_001746734.1 4910391 R 439855 CDS YP_001746735.1 170681444 6144928 complement(4911105..4912757) 1 NC_010498.1 hypothetical protein 4912757 6144928 EcSMS35_4824 Escherichia coli SMS-3-5 hypothetical protein YP_001746735.1 4911105 R 439855 CDS YP_001746736.1 170684274 6145629 4912969..4916328 1 NC_010498.1 hypothetical protein 4916328 6145629 EcSMS35_4825 Escherichia coli SMS-3-5 hypothetical protein YP_001746736.1 4912969 D 439855 CDS YP_001746737.1 170683318 6143576 4916328..4922642 1 NC_010498.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD/DEAH box helicase domain-containing protein 4922642 6143576 EcSMS35_4827 Escherichia coli SMS-3-5 DEAD/DEAH box helicase domain-containing protein YP_001746737.1 4916328 D 439855 CDS YP_001746738.1 170682756 6142603 complement(4922629..4922745) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4922745 6142603 EcSMS35_4826 Escherichia coli SMS-3-5 hypothetical protein YP_001746738.1 4922629 R 439855 CDS YP_001746739.1 170683792 6146965 4922866..4925724 1 NC_010498.1 identified by match to protein family HMM PF00176; match to protein family HMM PF00271; helicase family protein 4925724 6146965 EcSMS35_4828 Escherichia coli SMS-3-5 helicase family protein YP_001746739.1 4922866 D 439855 CDS YP_001746740.1 170679644 6143084 4925727..4930649 1 NC_010498.1 identified by similarity to GB:ABK43865.1; hypothetical protein 4930649 6143084 EcSMS35_4829 Escherichia coli SMS-3-5 hypothetical protein YP_001746740.1 4925727 D 439855 CDS YP_001746741.1 170680718 6143801 4930649..4936990 1 NC_010498.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD/DEAH box helicase domain-containing protein 4936990 6143801 EcSMS35_4830 Escherichia coli SMS-3-5 DEAD/DEAH box helicase domain-containing protein YP_001746741.1 4930649 D 439855 CDS YP_001746742.1 170681239 6144893 4936987..4939101 1 NC_010498.1 identified by match to protein family HMM PF00580; ATP-dependent DNA helicase UvrD 4939101 6144893 EcSMS35_4831 Escherichia coli SMS-3-5 ATP-dependent DNA helicase UvrD YP_001746742.1 4936987 D 439855 CDS YP_001746743.1 170681736 6145423 complement(4939615..4940265) 1 NC_010498.1 identified by similarity to GB:CAJ67303.1; hypothetical protein 4940265 6145423 EcSMS35_4832 Escherichia coli SMS-3-5 hypothetical protein YP_001746743.1 4939615 R 439855 CDS YP_001746744.1 170681530 6145925 4941036..4941221 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4941221 6145925 EcSMS35_4833 Escherichia coli SMS-3-5 hypothetical protein YP_001746744.1 4941036 D 439855 CDS YP_001746745.1 170680361 6145715 complement(4941239..4942219) 1 NC_010498.1 identified by match to protein family HMM PF03629; hypothetical protein 4942219 6145715 EcSMS35_4834 Escherichia coli SMS-3-5 hypothetical protein YP_001746745.1 4941239 R 439855 CDS YP_001746746.1 170680477 6144529 complement(4942284..4943390) 1 NC_010498.1 identified by match to protein family HMM PF01344; match to protein family HMM PF07646; match to protein family HMM TIGR03547; N-acetylneuraminic acid mutarotase 4943390 6144529 EcSMS35_4835 Escherichia coli SMS-3-5 N-acetylneuraminic acid mutarotase YP_001746746.1 4942284 R 439855 CDS YP_001746747.1 170681359 6144646 complement(4943410..4944126) 1 NC_010498.1 identified by similarity to SP:P69856; match to protein family HMM PF06178; N-acetylneuraminic acid porin NanC 4944126 nanC 6144646 nanC Escherichia coli SMS-3-5 N-acetylneuraminic acid porin NanC YP_001746747.1 4943410 R 439855 CDS YP_001746748.1 170680903 6145543 complement(4944767..4944928) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4944928 6145543 EcSMS35_4837 Escherichia coli SMS-3-5 hypothetical protein YP_001746748.1 4944767 R 439855 CDS YP_001746749.1 170681303 6145082 4945581..4946183 1 NC_010498.1 inversion of on/off regulator of fimA; tyrosine recombinase 4946183 fimB 6145082 fimB Escherichia coli SMS-3-5 tyrosine recombinase YP_001746749.1 4945581 D 439855 CDS YP_001746750.1 170682577 6145487 4946661..4947257 1 NC_010498.1 inversion of on/off regulator of fimA; tyrosine recombinase 4947257 fimE 6145487 fimE Escherichia coli SMS-3-5 tyrosine recombinase YP_001746750.1 4946661 D 439855 CDS YP_001746751.1 170682340 6146782 4947738..4948286 1 NC_010498.1 identified by match to protein family HMM PF00419; type-1 fimbrial protein 4948286 6146782 EcSMS35_4840 Escherichia coli SMS-3-5 type-1 fimbrial protein YP_001746751.1 4947738 D 439855 CDS YP_001746752.1 170683401 6146539 4948393..4948890 1 NC_010498.1 identified by match to protein family HMM PF00419; type-1 fimbrial protein 4948890 6146539 EcSMS35_4842 Escherichia coli SMS-3-5 type-1 fimbrial protein YP_001746752.1 4948393 D 439855 CDS YP_001746753.1 170684135 6142687 complement(4948884..4949003) 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4949003 6142687 EcSMS35_4841 Escherichia coli SMS-3-5 hypothetical protein YP_001746753.1 4948884 R 439855 CDS YP_001746754.1 170683403 6143435 4949002..4949652 1 NC_010498.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein FimC 4949652 fimC 6143435 fimC Escherichia coli SMS-3-5 chaperone protein FimC YP_001746754.1 4949002 D 439855 CDS YP_001746755.1 170679720 6142689 4949785..4952355 1 NC_010498.1 identified by match to protein family HMM PF00577; outer membrane usher protein fimD 4952355 fimD1 6142689 fimD1 Escherichia coli SMS-3-5 outer membrane usher protein fimD YP_001746755.1 4949785 D 439855 CDS YP_001746756.1 170681901 6143878 4952365..4952895 1 NC_010498.1 identified by match to protein family HMM PF00419; fimbrial protein FimF 4952895 fimF 6143878 fimF Escherichia coli SMS-3-5 fimbrial protein FimF YP_001746756.1 4952365 D 439855 CDS YP_001746757.1 170681547 6146096 4952908..4953411 1 NC_010498.1 identified by match to protein family HMM PF00419; protein fimG 4953411 fimG 6146096 fimG Escherichia coli SMS-3-5 protein fimG YP_001746757.1 4952908 D 439855 CDS YP_001746758.1 170681950 6145732 4953431..4954333 1 NC_010498.1 identified by match to protein family HMM PF00419; match to protein family HMM PF09160; protein FimH 4954333 fimH 6145732 fimH Escherichia coli SMS-3-5 protein FimH YP_001746758.1 4953431 D 439855 CDS YP_001746759.1 170682985 6146146 complement(4954576..4955919) 1 NC_010498.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; fructuronate transporter 4955919 gntP 6146146 gntP Escherichia coli SMS-3-5 fructuronate transporter YP_001746759.1 4954576 R 439855 CDS YP_001746760.1 170683309 6147201 4956259..4957443 1 NC_010498.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4957443 uxuA 6147201 uxuA Escherichia coli SMS-3-5 mannonate dehydratase YP_001746760.1 4956259 D 439855 CDS YP_001746761.1 170684062 6147535 4957524..4958984 1 NC_010498.1 identified by similarity to SP:P39160; match to protein family HMM PF01232; match to protein family HMM PF08125; fructuronate reductase 4958984 uxuB 6147535 uxuB Escherichia coli SMS-3-5 fructuronate reductase YP_001746761.1 4957524 D 439855 CDS YP_001746762.1 170679995 6143362 4959307..4960080 1 NC_010498.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4960080 6143362 EcSMS35_4851 Escherichia coli SMS-3-5 DNA-binding transcriptional repressor UxuR YP_001746762.1 4959307 D 439855 CDS YP_001746763.1 170679729 6144157 complement(4960221..4961051) 1 NC_010498.1 hypothetical protein 4961051 6144157 EcSMS35_4852 Escherichia coli SMS-3-5 hypothetical protein YP_001746763.1 4960221 R 439855 CDS YP_001746764.1 170681261 6143887 4961384..4961527 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4961527 6143887 EcSMS35_4853 Escherichia coli SMS-3-5 hypothetical protein YP_001746764.1 4961384 D 439855 CDS YP_001746765.1 170680965 6145445 4961623..4961757 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4961757 6145445 EcSMS35_4854 Escherichia coli SMS-3-5 hypothetical protein YP_001746765.1 4961623 D 439855 CDS YP_001746766.1 170683181 6145146 4961723..4962106 1 NC_010498.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4962106 iraD 6145146 iraD Escherichia coli SMS-3-5 DNA replication/recombination/repair protein YP_001746766.1 4961723 D 439855 CDS YP_001746767.1 170680317 6147401 complement(4962154..4964535) 1 NC_010498.1 identified by match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF03610; match to protein family HMM PF05524; match to protein family HMM TIGR01003; match to protein family HMM TIGR01417; match to protein family HMM TIGR02364; phosphoenolpyruvate-protein phosphotransferase PtnE 4964535 ptnE 6147401 ptnE Escherichia coli SMS-3-5 phosphoenolpyruvate-protein phosphotransferase PtnE YP_001746767.1 4962154 R 439855 CDS YP_001746768.1 170684228 6144485 complement(4964539..4965171) 1 NC_010498.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 4965171 ptnK 6144485 ptnK Escherichia coli SMS-3-5 dihydroxyacetone kinase subunit DhaL YP_001746768.1 4964539 R 439855 CDS YP_001746769.1 170683691 6143529 complement(4965184..4966248) 1 NC_010498.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 4966248 ptnC 6143529 ptnC Escherichia coli SMS-3-5 dihydroxyacetone kinase subunit DhaK YP_001746769.1 4965184 R 439855 CDS YP_001746770.1 170682881 6142983 4966574..4967656 1 NC_010498.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4967656 gldA 6142983 gldA Escherichia coli SMS-3-5 glycerol dehydrogenase YP_001746770.1 4966574 D 439855 CDS YP_001746771.1 170682292 6147094 4967724..4968992 1 NC_010498.1 identified by similarity to GB:AAL61900.1; match to protein family HMM PF07690; major facilitator family protein CglT 4968992 cglT 6147094 cglT Escherichia coli SMS-3-5 major facilitator family protein CglT YP_001746771.1 4967724 D 439855 CDS YP_001746772.1 170681610 6146491 4969010..4970374 1 NC_010498.1 identified by similarity to GB:AAL61901.1; match to protein family HMM PF01266; dihydrolipoamide dehydrogenase CglE 4970374 cglE 6146491 cglE Escherichia coli SMS-3-5 dihydrolipoamide dehydrogenase CglE YP_001746772.1 4969010 D 439855 CDS YP_001746773.1 170682254 6145795 4970675..4972216 1 NC_010498.1 identified by similarity to GB:AAL61902.1; match to protein family HMM PF02028; putative carnitine transporter CglC 4972216 6145795 EcSMS35_4862 Escherichia coli SMS-3-5 putative carnitine transporter CglC YP_001746773.1 4970675 D 439855 CDS YP_001746774.1 170682944 6146453 complement(4972272..4973414) 1 NC_010498.1 identified by similarity to GB:AAL61903.1; match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase GcxK 4973414 gcxK 6146453 gcxK Escherichia coli SMS-3-5 glycerate kinase GcxK YP_001746774.1 4972272 R 439855 CDS YP_001746775.1 170683692 6147159 complement(4973489..4974376) 1 NC_010498.1 identified by similarity to GB:AAL61904.1; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR01505; 2-hydroxy-3-oxopropionate reductase GcxR 4974376 gcxR 6147159 gcxR Escherichia coli SMS-3-5 2-hydroxy-3-oxopropionate reductase GcxR YP_001746775.1 4973489 R 439855 CDS YP_001746776.1 170683198 6142984 complement(4974394..4975176) 1 NC_010498.1 identified by similarity to GB:AAL61906.1; match to protein family HMM PF01261; match to protein family HMM TIGR03234; hydroxypyruvate isomerase Gcxl 4975176 gcxI 6142984 gcxI Escherichia coli SMS-3-5 hydroxypyruvate isomerase Gcxl YP_001746776.1 4974394 R 439855 CDS YP_001746777.1 170682697 6147418 complement(4975189..4976928) 1 NC_010498.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 4976928 gcxC 6147418 gcxC Escherichia coli SMS-3-5 glyoxylate carboligase YP_001746777.1 4975189 R 439855 CDS YP_001746778.1 170682161 6146905 4977307..4979256 1 NC_010498.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 4979256 6146905 EcSMS35_4867 Escherichia coli SMS-3-5 DNA-binding transcriptional regulator DhaR YP_001746778.1 4977307 D 439855 CDS YP_001746779.1 170682712 6146360 4979543..4980913 1 NC_010498.1 identified by similarity to GB:AAL61901.1; match to protein family HMM PF01266; invasion protein IbeA 4980913 ibeA 6146360 ibeA Escherichia coli SMS-3-5 invasion protein IbeA YP_001746779.1 4979543 D 439855 CDS YP_001746780.1 170680669 6146920 4980928..4982331 1 NC_010498.1 identified by similarity to GB:AAL61908.1; match to protein family HMM PF03553; match to protein family HMM TIGR00931; Na+/H+ antiporter IbeT 4982331 ibeT 6146920 ibeT Escherichia coli SMS-3-5 Na+/H+ antiporter IbeT YP_001746780.1 4980928 D 439855 CDS YP_001746781.1 170679932 6144844 complement(4982418..4983329) 1 NC_010498.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 4983329 6144844 EcSMS35_4870 Escherichia coli SMS-3-5 putative DNA-binding transcriptional regulator YP_001746781.1 4982418 R 439855 CDS YP_001746782.1 170683847 6144094 complement(4983394..4984566) 1 NC_010498.1 identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01975; isoaspartyl dipeptidase 4984566 iadA 6144094 iadA Escherichia coli SMS-3-5 isoaspartyl dipeptidase YP_001746782.1 4983394 R 439855 CDS YP_001746783.1 170683169 6143141 complement(4984579..4985040) 1 NC_010498.1 identified by match to protein family HMM PF07670; hypothetical protein 4985040 6143141 EcSMS35_4872 Escherichia coli SMS-3-5 hypothetical protein YP_001746783.1 4984579 R 439855 CDS YP_001746784.1 170682282 6147389 complement(4985037..4985720) 1 NC_010498.1 identified by match to protein family HMM PF07670; putative transporter 4985720 6147389 EcSMS35_4873 Escherichia coli SMS-3-5 putative transporter YP_001746784.1 4985037 R 439855 CDS YP_001746785.1 170682859 6146481 4985750..4985905 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 4985905 6146481 EcSMS35_4874 Escherichia coli SMS-3-5 hypothetical protein YP_001746785.1 4985750 D 439855 CDS YP_001746786.1 170683612 6147072 4985970..4986554 1 NC_010498.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4986554 kptA 6147072 kptA Escherichia coli SMS-3-5 RNA 2'-phosphotransferase-like protein YP_001746786.1 4985970 D 439855 CDS YP_001746787.1 170684166 6142902 complement(4986675..4991915) 1 NC_010498.1 identified by match to protein family HMM PF02369; putative invasin 4991915 6142902 EcSMS35_4876 Escherichia coli SMS-3-5 putative invasin YP_001746787.1 4986675 R 439855 CDS YP_001746788.1 170680267 6143466 complement(4992126..4993304) 1 NC_010498.1 identified by match to protein family HMM PF06779; match to protein family HMM PF07690; major facilitator transporter 4993304 6143466 EcSMS35_4877 Escherichia coli SMS-3-5 major facilitator transporter YP_001746788.1 4992126 R 439855 CDS YP_001746789.1 170683147 6144434 complement(4993372..4994361) 1 NC_010498.1 identified by match to protein family HMM PF06977; SdiA-regulated protein 4994361 6144434 EcSMS35_4878 Escherichia coli SMS-3-5 SdiA-regulated protein YP_001746789.1 4993372 R 439855 CDS YP_001746790.1 170681566 6147367 complement(4994469..4996442) 1 NC_010498.1 identified by match to protein family HMM PF00805; pentapeptide repeat-containing protein 4996442 6147367 EcSMS35_4879 Escherichia coli SMS-3-5 pentapeptide repeat-containing protein YP_001746790.1 4994469 R 439855 CDS YP_001746791.1 170679979 6145751 complement(4996764..4997030) 1 NC_010498.1 identified by similarity to GB:ABC78983.1; hypothetical protein 4997030 6145751 EcSMS35_4880 Escherichia coli SMS-3-5 hypothetical protein YP_001746791.1 4996764 R 439855 CDS YP_001746792.1 170681785 6144141 complement(4997027..4997794) 1 NC_010498.1 identified by match to protein family HMM PF01869; match to protein family HMM TIGR00241; (R)-2-hydroxyglutaryl-CoA dehydratase activator 4997794 hgdC 6144141 hgdC Escherichia coli SMS-3-5 (R)-2-hydroxyglutaryl-CoA dehydratase activator YP_001746792.1 4997027 R 439855 CDS YP_001746793.1 170680225 6145977 complement(4997804..4998955) 1 NC_010498.1 identified by match to protein family HMM PF06050; putative 2-hydroxyglutaryl-CoA dehydratase, D-component 4998955 6145977 EcSMS35_4882 Escherichia coli SMS-3-5 putative 2-hydroxyglutaryl-CoA dehydratase, D-component YP_001746793.1 4997804 R 439855 CDS YP_001746794.1 170681238 6144391 complement(4999070..5000350) 1 NC_010498.1 identified by match to protein family HMM PF04286; hypothetical protein 5000350 6144391 EcSMS35_4883 Escherichia coli SMS-3-5 hypothetical protein YP_001746794.1 4999070 R 439855 CDS YP_001746795.1 170681905 6145422 complement(5000391..5001623) 1 NC_010498.1 identified by match to protein family HMM PF07690; multidrug resistance protein MdtM 5001623 mdtM 6145422 mdtM Escherichia coli SMS-3-5 multidrug resistance protein MdtM YP_001746795.1 5000391 R 439855 CDS YP_001746796.1 170679958 6146100 5002090..5003046 1 NC_010498.1 identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 5003046 6146100 EcSMS35_4885 Escherichia coli SMS-3-5 hypothetical protein YP_001746796.1 5002090 D 439855 CDS YP_001746797.1 170680887 6144120 complement(5003289..5004701) 1 NC_010498.1 identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator 5004701 6144120 EcSMS35_4886 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001746797.1 5003289 R 439855 CDS YP_001746798.1 170683949 6145065 5004878..5005042 1 NC_010498.1 identified by match to protein family HMM PF06568; hypothetical protein 5005042 6145065 EcSMS35_4887 Escherichia coli SMS-3-5 hypothetical protein YP_001746798.1 5004878 D 439855 CDS YP_001746799.1 170679657 6143246 5005139..5007232 1 NC_010498.1 identified by similarity to GB:CAH55816.1; match to protein family HMM PF03235; match to protein family HMM PF07510; hypothetical protein 5007232 6143246 EcSMS35_4888 Escherichia coli SMS-3-5 hypothetical protein YP_001746799.1 5005139 D 439855 CDS YP_001746800.1 170682640 6143815 complement(5007279..5007677) 1 NC_010498.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 5007677 6143815 EcSMS35_4889 Escherichia coli SMS-3-5 endoribonuclease SymE YP_001746800.1 5007279 R 439855 CDS YP_001746801.1 170683581 6142914 complement(5008273..5010123) 1 NC_010498.1 identified by similarity to GB:AAW87205.1; hypothetical protein 5010123 6142914 EcSMS35_4891 Escherichia coli SMS-3-5 hypothetical protein YP_001746801.1 5008273 R 439855 CDS YP_001746802.1 170680984 6142872 complement(5010454..5011410) 1 NC_010498.1 identified by match to protein family HMM PF02492; match to protein family HMM PF07683; putative GTP-binding protein YjiA 5011410 6142872 EcSMS35_4892 Escherichia coli SMS-3-5 putative GTP-binding protein YjiA YP_001746802.1 5010454 R 439855 CDS YP_001746803.1 170681608 6145165 complement(5011421..5011624) 1 NC_010498.1 identified by match to protein family HMM PF04328; hypothetical protein 5011624 6145165 EcSMS35_4893 Escherichia coli SMS-3-5 hypothetical protein YP_001746803.1 5011421 R 439855 CDS YP_001746804.1 170679606 6145793 complement(5011674..5013788) 1 NC_010498.1 identified by match to protein family HMM PF02554; carbon starvation family protein 5013788 6145793 EcSMS35_4894 Escherichia coli SMS-3-5 carbon starvation family protein YP_001746804.1 5011674 R 439855 CDS YP_001746805.1 170680265 6143763 complement(5014092..5015312) 1 NC_010498.1 identified by similarity to GB:AAD56429.1; putative D-serine ammonia-lyase 5015312 6143763 EcSMS35_4895 Escherichia coli SMS-3-5 putative D-serine ammonia-lyase YP_001746805.1 5014092 R 439855 CDS YP_001746806.1 170683584 6144432 5015513..5016955 1 NC_010498.1 identified by similarity to SP:P72349; match to protein family HMM PF07908; match to protein family HMM PF07969; N-acyl-D-amino-acid deacylase family protein 5016955 6144432 EcSMS35_4896 Escherichia coli SMS-3-5 N-acyl-D-amino-acid deacylase family protein YP_001746806.1 5015513 D 439855 CDS YP_001746807.1 170679647 6142875 5016965..5017354 1 NC_010498.1 yfgF; identified by match to protein family HMM PF01042; putative endoribonuclease L-PSP 5017354 6142875 EcSMS35_4897 Escherichia coli SMS-3-5 putative endoribonuclease L-PSP YP_001746807.1 5016965 D 439855 CDS YP_001746808.1 170682270 6143804 5017457..5018926 1 NC_010498.1 identified by match to protein family HMM PF00474; solute/sodium symporter (SSS) family protein 5018926 6143804 EcSMS35_4898 Escherichia coli SMS-3-5 solute/sodium symporter (SSS) family protein YP_001746808.1 5017457 D 439855 CDS YP_001746809.1 170682954 6146469 complement(5018936..5019799) 1 NC_010498.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator 5019799 6146469 EcSMS35_4899 Escherichia coli SMS-3-5 RpiR family transcriptional regulator YP_001746809.1 5018936 R 439855 CDS YP_001746810.1 170682951 6147169 5019981..5021645 1 NC_010498.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein I 5021645 tsr 6147169 tsr Escherichia coli SMS-3-5 methyl-accepting chemotaxis protein I YP_001746810.1 5019981 D 439855 CDS YP_001746811.1 170683547 6147166 complement(5021694..5023055) 1 NC_010498.1 identified by match to protein family HMM PF07690; major facilitator transporter 5023055 6147166 EcSMS35_4901 Escherichia coli SMS-3-5 major facilitator transporter YP_001746811.1 5021694 R 439855 CDS YP_001746812.1 170683487 6142837 complement(5023270..5024184) 1 NC_010498.1 identified by match to protein family HMM PF07729; GntR family transcriptional regulator 5024184 6142837 EcSMS35_4902 Escherichia coli SMS-3-5 GntR family transcriptional regulator YP_001746812.1 5023270 R 439855 CDS YP_001746813.1 170683258 6142776 5024323..5025345 1 NC_010498.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 5025345 6142776 EcSMS35_4903 Escherichia coli SMS-3-5 zinc-binding dehydrogenase family oxidoreductase YP_001746813.1 5024323 D 439855 CDS YP_001746814.1 170682467 6147481 complement(5025483..5027774) 1 NC_010498.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 5027774 mdoB 6147481 mdoB Escherichia coli SMS-3-5 phosphoglycerol transferase I YP_001746814.1 5025483 R 439855 CDS YP_001746815.1 170682844 6146666 complement(5028028..5028525) 1 NC_010498.1 hypothetical protein 5028525 6146666 EcSMS35_4905 Escherichia coli SMS-3-5 hypothetical protein YP_001746815.1 5028028 R 439855 CDS YP_001746816.1 170680779 6147056 complement(5028571..5029308) 1 NC_010498.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 5029308 dnaC 6147056 dnaC Escherichia coli SMS-3-5 DNA replication protein DnaC YP_001746816.1 5028571 R 439855 CDS YP_001746817.1 170681424 6144954 complement(5029311..5029850) 1 NC_010498.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 5029850 dnaT 6144954 dnaT Escherichia coli SMS-3-5 primosomal protein DnaI YP_001746817.1 5029311 R 439855 CDS YP_001746818.1 170679763 6145608 complement(5029957..5030424) 1 NC_010498.1 hypothetical protein 5030424 6145608 EcSMS35_4908 Escherichia coli SMS-3-5 hypothetical protein YP_001746818.1 5029957 R 439855 CDS YP_001746819.1 170680390 6143922 complement(5030421..5031245) 1 NC_010498.1 identified by match to protein family HMM PF06738; hypothetical protein 5031245 6143922 EcSMS35_4909 Escherichia coli SMS-3-5 hypothetical protein YP_001746819.1 5030421 R 439855 CDS YP_001746820.1 170682121 6144559 5031269..5031403 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 5031403 6144559 EcSMS35_4910 Escherichia coli SMS-3-5 hypothetical protein YP_001746820.1 5031269 D 439855 CDS YP_001746821.1 170682807 6146320 5031809..5032534 1 NC_010498.1 identified by match to protein family HMM PF00196; LuxR family transcriptional regulator 5032534 6146320 EcSMS35_4911 Escherichia coli SMS-3-5 LuxR family transcriptional regulator YP_001746821.1 5031809 D 439855 CDS YP_001746822.1 170680066 6147018 5032492..5033169 1 NC_010498.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5033169 6147018 EcSMS35_4912 Escherichia coli SMS-3-5 DNA-binding transcriptional activator BglJ YP_001746822.1 5032492 D 439855 CDS YP_001746823.1 170680716 6144230 complement(5033208..5033996) 1 NC_010498.1 identified by match to protein family HMM PF06276; ferric iron reductase involved in ferric hydroximate transport 5033996 fhuF 6144230 fhuF Escherichia coli SMS-3-5 ferric iron reductase involved in ferric hydroximate transport YP_001746823.1 5033208 R 439855 CDS YP_001746824.1 170681067 6144891 5034098..5034373 1 NC_010498.1 identified by match to protein family HMM PF07256; hypothetical protein 5034373 6144891 EcSMS35_4914 Escherichia coli SMS-3-5 hypothetical protein YP_001746824.1 5034098 D 439855 CDS YP_001746825.1 170681708 6143662 complement(5035035..5036066) 1 NC_010498.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 5036066 rsmC 6143662 rsmC Escherichia coli SMS-3-5 16S ribosomal RNA m2G1207 methyltransferase YP_001746825.1 5035035 R 439855 CDS YP_001746826.1 170682908 6145895 5036169..5036582 1 NC_010498.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5036582 holD 6145895 holD Escherichia coli SMS-3-5 DNA polymerase III subunit psi YP_001746826.1 5036169 D 439855 CDS YP_001746827.1 170682662 6147122 5036551..5036997 1 NC_010498.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5036997 rimI 6147122 rimI Escherichia coli SMS-3-5 ribosomal-protein-alanine N-acetyltransferase YP_001746827.1 5036551 D 439855 CDS YP_001746828.1 170683179 6146869 5037012..5037689 1 NC_010498.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5037689 yjjG 6146869 yjjG Escherichia coli SMS-3-5 nucleotidase YP_001746828.1 5037012 D 439855 CDS YP_001746829.1 170683721 6147399 5037780..5039369 1 NC_010498.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5039369 prfC 6147399 prfC Escherichia coli SMS-3-5 peptide chain release factor 3 YP_001746829.1 5037780 D 439855 CDS YP_001746830.1 170680154 6143013 5039762..5040367 1 NC_010498.1 identified by match to protein family HMM PF04972; periplasmic protein 5040367 osmY 6143013 osmY Escherichia coli SMS-3-5 periplasmic protein YP_001746830.1 5039762 D 439855 CDS YP_001746831.1 170680824 6144320 5040494..5040655 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 5040655 6144320 EcSMS35_4924 Escherichia coli SMS-3-5 hypothetical protein YP_001746831.1 5040494 D 439855 CDS YP_001746832.1 170684165 6145001 5040777..5041850 1 NC_010498.1 identified by match to protein family HMM PF01734; patatin family phospholipase 5041850 6145001 EcSMS35_4925 Escherichia coli SMS-3-5 patatin family phospholipase YP_001746832.1 5040777 D 439855 CDS YP_001746833.1 170680245 6143465 5041847..5042629 1 NC_010498.1 identified by match to protein family HMM PF01026; putative deoxyribonuclease YjjV 5042629 6143465 EcSMS35_4926 Escherichia coli SMS-3-5 putative deoxyribonuclease YjjV YP_001746833.1 5041847 D 439855 CDS YP_001746834.1 170679719 6144412 complement(5042659..5043522) 1 NC_010498.1 identified by match to protein family HMM PF04055; radical SAM domain-containing protein 5043522 6144412 EcSMS35_4927 Escherichia coli SMS-3-5 radical SAM domain-containing protein YP_001746834.1 5042659 R 439855 CDS YP_001746835.1 170681370 6143877 complement(5043494..5045044) 1 NC_010498.1 hypothetical protein 5045044 6143877 EcSMS35_4928 Escherichia coli SMS-3-5 hypothetical protein YP_001746835.1 5043494 R 439855 CDS YP_001746836.1 170681505 6145554 5045020..5045145 1 NC_010498.1 hypothetical protein 5045145 6145554 EcSMS35_4929 Escherichia coli SMS-3-5 hypothetical protein YP_001746836.1 5045020 D 439855 CDS YP_001746837.1 170681011 6145690 5045302..5046081 1 NC_010498.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5046081 deoC 6145690 deoC Escherichia coli SMS-3-5 deoxyribose-phosphate aldolase YP_001746837.1 5045302 D 439855 CDS YP_001746838.1 170682854 6145192 5046159..5047481 1 NC_010498.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5047481 deoA 6145192 deoA Escherichia coli SMS-3-5 thymidine phosphorylase YP_001746838.1 5046159 D 439855 CDS YP_001746839.1 170682473 6147067 5047533..5048756 1 NC_010498.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5048756 deoB 6147067 deoB Escherichia coli SMS-3-5 phosphopentomutase YP_001746839.1 5047533 D 439855 CDS YP_001746840.1 170680308 6146672 5048813..5049532 1 NC_010498.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5049532 deoD 6146672 deoD Escherichia coli SMS-3-5 purine nucleoside phosphorylase YP_001746840.1 5048813 D 439855 CDS YP_001746841.1 170679640 6144476 complement(5049693..5049956) 1 NC_010498.1 hypothetical protein 5049956 6144476 EcSMS35_4934 Escherichia coli SMS-3-5 hypothetical protein YP_001746841.1 5049693 R 439855 CDS YP_001746842.1 170680705 6143797 complement(5049988..5051004) 1 NC_010498.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 5051004 lplA 6143797 lplA Escherichia coli SMS-3-5 lipoate-protein ligase A YP_001746842.1 5049988 R 439855 CDS YP_001746843.1 170680070 6144880 complement(5051032..5051676) 1 NC_010498.1 hypothetical protein 5051676 6144880 EcSMS35_4936 Escherichia coli SMS-3-5 hypothetical protein YP_001746843.1 5051032 R 439855 CDS YP_001746844.1 170681720 6144234 5051782..5052750 1 NC_010498.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5052750 serB 6144234 serB Escherichia coli SMS-3-5 phosphoserine phosphatase YP_001746844.1 5051782 D 439855 CDS YP_001746845.1 170681066 6145908 5052799..5054181 1 NC_010498.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5054181 radA 6145908 radA Escherichia coli SMS-3-5 DNA repair protein RadA YP_001746845.1 5052799 D 439855 CDS YP_001746846.1 170682167 6145248 5054202..5055434 1 NC_010498.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5055434 nadR 6145248 nadR Escherichia coli SMS-3-5 nicotinamide-nucleotide adenylyltransferase YP_001746846.1 5054202 D 439855 CDS YP_001746847.1 170683983 6146366 5055468..5055635 1 NC_010498.1 hypothetical protein 5055635 6146366 EcSMS35_4940 Escherichia coli SMS-3-5 hypothetical protein YP_001746847.1 5055468 D 439855 CDS YP_001746848.1 170683563 6143281 complement(5055742..5057409) 1 NC_010498.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 5057409 6143281 EcSMS35_4941 Escherichia coli SMS-3-5 putative ABC transporter ATP-binding protein YP_001746848.1 5055742 R 439855 CDS YP_001746849.1 170680234 6142853 5057383..5057511 1 NC_010498.1 identified by Glimmer3; putative; hypothetical protein 5057511 6142853 EcSMS35_4942 Escherichia coli SMS-3-5 hypothetical protein YP_001746849.1 5057383 D 439855 CDS YP_001746850.1 170679874 6144401 5057620..5059557 1 NC_010498.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5059557 slt 6144401 slt Escherichia coli SMS-3-5 lytic murein transglycosylase YP_001746850.1 5057620 D 439855 CDS YP_001746851.1 170679610 6144036 5059647..5059973 1 NC_010498.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5059973 trpR 6144036 trpR Escherichia coli SMS-3-5 Trp operon repressor YP_001746851.1 5059647 D 439855 CDS YP_001746852.1 170681811 6143767 complement(5059967..5060491) 1 NC_010498.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 5060491 6143767 EcSMS35_4944 Escherichia coli SMS-3-5 NTPase YP_001746852.1 5059967 R 439855 CDS YP_001746853.1 170681305 6146004 5060534..5061181 1 NC_010498.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5061181 6146004 EcSMS35_4947 Escherichia coli SMS-3-5 phosphoglycerate mutase YP_001746853.1 5060534 D 439855 CDS YP_001746854.1 170681808 6145489 complement(5061178..5062047) 1 NC_010498.1 identified by match to protein family HMM PF00165; match to protein family HMM PF06445; right origin-binding protein 5062047 rob 6145489 rob Escherichia coli SMS-3-5 right origin-binding protein YP_001746854.1 5061178 R 439855 CDS YP_001746855.1 170682862 6146001 5062258..5062731 1 NC_010498.1 identified by match to protein family HMM PF05981; hypothetical protein 5062731 6146001 EcSMS35_4948 Escherichia coli SMS-3-5 hypothetical protein YP_001746855.1 5062258 D 439855 CDS YP_001746856.1 170684107 6147075 5062744..5063433 1 NC_010498.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5063433 creB 6147075 creB Escherichia coli SMS-3-5 DNA-binding response regulator CreB YP_001746856.1 5062744 D 439855 CDS YP_001746857.1 170683413 6143407 5063433..5064857 1 NC_010498.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5064857 creC 6143407 creC Escherichia coli SMS-3-5 sensory histidine kinase CreC YP_001746857.1 5063433 D 439855 CDS YP_001746858.1 170683160 6142699 5064915..5066267 1 NC_010498.1 identified by match to protein family HMM PF06123; hypothetical protein 5066267 6142699 EcSMS35_4951 Escherichia coli SMS-3-5 hypothetical protein YP_001746858.1 5064915 D 439855 CDS YP_001746859.1 170680328 6147380 complement(5066326..5067042) 1 NC_010498.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; two-component response regulator 5067042 arcA 6147380 arcA Escherichia coli SMS-3-5 two-component response regulator YP_001746859.1 5066326 R 439855 CDS YP_001746860.1 170683598 6144496 5067678..5068364 1 NC_010498.1 member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 5068364 6144496 EcSMS35_4953 Escherichia coli SMS-3-5 putative RNA methyltransferase YP_001746860.1 5067678 D 439855 CDS