-- dump date 20140619_085909 -- class Genbank::misc_feature -- table misc_feature_note -- id note 386585000001 REFSEQ gene predictions performed by GeneMark 2.4/GeneMark.hmm 2.0 with comparison to original submitter provided annotation. 386585000002 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 386585000003 Peptidase M66; Region: Peptidase_M66; pfam10462 386585000004 REFSEQ gene predictions performed by GeneMark 2.4/GeneMark.hmm 2.0 with comparison to original submitter provided annotation. 386585000005 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 386585000006 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 386585000007 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 386585000008 type II secretion system protein D; Region: type_II_gspD; TIGR02517 386585000009 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 386585000010 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 386585000011 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 386585000012 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 386585000013 type II secretion system protein E; Region: type_II_gspE; TIGR02533 386585000014 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 386585000015 Walker A motif; other site 386585000016 ATP binding site [chemical binding]; other site 386585000017 Walker B motif; other site 386585000018 type II secretion system protein F; Region: GspF; TIGR02120 386585000019 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 386585000020 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 386585000021 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 386585000022 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 386585000023 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 386585000024 type II secretion system protein I; Region: gspI; TIGR01707 386585000025 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 386585000026 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 386585000027 type II secretion system protein J; Region: gspJ; TIGR01711 386585000028 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 386585000029 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 386585000030 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 386585000031 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 386585000032 GspL periplasmic domain; Region: GspL_C; pfam12693 386585000033 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 386585000034 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 386585000035 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 386585000036 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 386585000037 lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004 386585000038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585000039 Transposase; Region: HTH_Tnp_1; cl17663 386585000040 putative transposase OrfB; Reviewed; Region: PHA02517 386585000041 HTH-like domain; Region: HTH_21; pfam13276 386585000042 Integrase core domain; Region: rve; pfam00665 386585000043 Integrase core domain; Region: rve_3; pfam13683 386585000044 RTX toxin acyltransferase family; Region: HlyC; pfam02794 386585000045 RTX N-terminal domain; Region: RTX; pfam02382 386585000046 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 386585000047 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 386585000048 RTX C-terminal domain; Region: RTX_C; pfam08339 386585000049 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 386585000050 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 386585000051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585000052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585000053 Walker A/P-loop; other site 386585000054 ATP binding site [chemical binding]; other site 386585000055 Q-loop/lid; other site 386585000056 ABC transporter signature motif; other site 386585000057 Walker B; other site 386585000058 D-loop; other site 386585000059 H-loop/switch region; other site 386585000060 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 386585000061 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585000062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 386585000063 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585000064 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 386585000065 active site 386585000066 catalytic residues [active] 386585000067 DNA binding site [nucleotide binding] 386585000068 Int/Topo IB signature motif; other site 386585000069 Initiator Replication protein; Region: Rep_3; pfam01051 386585000070 HYD1 signature containing ADP-ribosyltransferase; Region: Tox-ART-HYD1; pfam15633 386585000071 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 386585000072 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 386585000073 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 386585000074 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 386585000075 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 386585000076 active site 386585000077 catalytic residues [active] 386585000078 DNA binding site [nucleotide binding] 386585000079 Int/Topo IB signature motif; other site 386585000080 putative transposase OrfB; Reviewed; Region: PHA02517 386585000081 HTH-like domain; Region: HTH_21; pfam13276 386585000082 Integrase core domain; Region: rve; pfam00665 386585000083 Integrase core domain; Region: rve_3; pfam13683 386585000084 Transposase; Region: HTH_Tnp_1; cl17663 386585000085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585000086 similar to Rep protein 386585000087 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 386585000088 MerR family regulatory protein; Region: MerR; pfam00376 386585000089 DNA binding residues [nucleotide binding] 386585000090 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 386585000091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585000092 P-loop; other site 386585000093 Magnesium ion binding site [ion binding]; other site 386585000094 plasmid-partitioning protein; Provisional; Region: PRK13698 386585000095 ParB-like nuclease domain; Region: ParB; smart00470 386585000096 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 386585000097 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 386585000098 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 386585000099 putative active site [active] 386585000100 putative NTP binding site [chemical binding]; other site 386585000101 putative nucleic acid binding site [nucleotide binding]; other site 386585000102 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 386585000103 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585000104 active site 386585000105 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 386585000106 putative methylase; Provisional; Region: PRK13699 386585000107 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 386585000108 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 386585000109 Protein of unknown function (DUF1472); Region: DUF1472; pfam07339 386585000110 Antirestriction protein; Region: Antirestrict; pfam03230 386585000111 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 386585000112 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 386585000113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585000114 S-adenosylmethionine binding site [chemical binding]; other site 386585000115 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 386585000116 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 386585000117 dimer interface [polypeptide binding]; other site 386585000118 ssDNA binding site [nucleotide binding]; other site 386585000119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585000120 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 386585000121 ParB-like nuclease domain; Region: ParBc; pfam02195 386585000122 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 386585000123 KorB domain; Region: KorB; pfam08535 386585000124 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 386585000125 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 386585000126 small toxic polypeptide; Provisional; Region: PRK09738 386585000127 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 386585000128 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 386585000129 TolA C-terminal; Region: TolA; pfam06519 386585000130 Integrase core domain; Region: rve; pfam00665 386585000131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 386585000132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 386585000133 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 386585000134 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 386585000135 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 386585000136 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 386585000137 putative transposase OrfB; Reviewed; Region: PHA02517 386585000138 Transposase; Region: HTH_Tnp_1; cl17663 386585000139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 386585000141 similar to helicase I 386585000142 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 386585000143 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585000144 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 386585000145 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 386585000146 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 386585000147 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 386585000148 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 386585000149 putative kissing complex interaction region; other site 386585000150 putative RNA binding sites [nucleotide binding]; other site 386585000151 Staphylococcal nuclease homologues; Region: SNc; smart00318 386585000152 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 386585000153 Catalytic site; other site 386585000154 Haemolysin expression modulating protein; Region: HHA; pfam05321 386585000155 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 386585000156 replication protein; Provisional; Region: PRK13702 386585000157 replication protein; Provisional; Region: PRK13750 386585000158 Predicted transcriptional regulator [Transcription]; Region: COG3905 386585000159 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 386585000160 similar to transposase 386585000161 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 386585000162 putative transposase OrfB; Reviewed; Region: PHA02517 386585000163 HTH-like domain; Region: HTH_21; pfam13276 386585000164 Integrase core domain; Region: rve; pfam00665 386585000165 Integrase core domain; Region: rve_3; pfam13683 386585000166 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 386585000167 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 386585000168 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 386585000169 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585000170 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585000171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 386585000172 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 386585000173 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 386585000174 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 386585000175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 386585000176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 386585000177 hypothetical protein; Provisional; Region: PRK10649 386585000178 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 386585000179 Sulfatase; Region: Sulfatase; pfam00884 386585000180 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 386585000181 putative acyl-acceptor binding pocket; other site 386585000182 REFSEQ gene predictions performed by GeneMark 2.4/GeneMark.hmm 2.0 with comparison to original submitter provided annotation. 386585000183 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 386585000184 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 386585000185 putative catalytic residues [active] 386585000186 putative nucleotide binding site [chemical binding]; other site 386585000187 putative aspartate binding site [chemical binding]; other site 386585000188 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 386585000189 dimer interface [polypeptide binding]; other site 386585000190 putative threonine allosteric regulatory site; other site 386585000191 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 386585000192 putative threonine allosteric regulatory site; other site 386585000193 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 386585000194 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 386585000195 homoserine kinase; Region: thrB; TIGR00191 386585000196 Protein of unknown function; Region: YhfT; pfam10797 386585000197 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 386585000198 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 386585000199 threonine synthase; Validated; Region: PRK09225 386585000200 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 386585000201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585000202 catalytic residue [active] 386585000203 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 386585000204 hypothetical protein; Validated; Region: PRK02101 386585000205 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 386585000206 transaldolase-like protein; Provisional; Region: PTZ00411 386585000207 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 386585000208 active site 386585000209 dimer interface [polypeptide binding]; other site 386585000210 catalytic residue [active] 386585000211 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 386585000212 MPT binding site; other site 386585000213 trimer interface [polypeptide binding]; other site 386585000214 hypothetical protein; Provisional; Region: PRK10659 386585000215 hypothetical protein; Provisional; Region: PRK10236 386585000216 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 386585000217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 386585000218 hypothetical protein; Provisional; Region: PRK10154 386585000219 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 386585000220 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 386585000221 nucleotide binding site [chemical binding]; other site 386585000222 NEF interaction site [polypeptide binding]; other site 386585000223 SBD interface [polypeptide binding]; other site 386585000224 chaperone protein DnaJ; Provisional; Region: PRK10767 386585000225 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 386585000226 HSP70 interaction site [polypeptide binding]; other site 386585000227 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 386585000228 substrate binding site [polypeptide binding]; other site 386585000229 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 386585000230 Zn binding sites [ion binding]; other site 386585000231 dimer interface [polypeptide binding]; other site 386585000232 Hok/gef family; Region: HOK_GEF; pfam01848 386585000233 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 386585000234 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 386585000235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585000236 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 386585000237 putative dimerization interface [polypeptide binding]; other site 386585000238 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 386585000239 PapC N-terminal domain; Region: PapC_N; pfam13954 386585000240 Outer membrane usher protein; Region: Usher; pfam00577 386585000241 PapC C-terminal domain; Region: PapC_C; pfam13953 386585000242 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 386585000243 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585000244 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585000245 Fimbrial protein; Region: Fimbrial; cl01416 386585000246 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 386585000247 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 386585000248 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 386585000249 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 386585000250 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 386585000251 active site 386585000252 Riboflavin kinase; Region: Flavokinase; smart00904 386585000253 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 386585000254 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 386585000255 active site 386585000256 HIGH motif; other site 386585000257 KMSKS motif; other site 386585000258 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 386585000259 tRNA binding surface [nucleotide binding]; other site 386585000260 anticodon binding site; other site 386585000261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 386585000262 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 386585000263 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 386585000264 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 386585000265 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 386585000266 Fe-S cluster binding site [ion binding]; other site 386585000267 substrate binding site [chemical binding]; other site 386585000268 catalytic site [active] 386585000269 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 386585000270 active site 386585000271 tetramer interface [polypeptide binding]; other site 386585000272 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 386585000273 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 386585000274 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 386585000275 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 386585000276 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 386585000277 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 386585000278 catalytic site [active] 386585000279 subunit interface [polypeptide binding]; other site 386585000280 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 386585000281 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 386585000282 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 386585000283 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 386585000284 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 386585000285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 386585000286 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 386585000287 IMP binding site; other site 386585000288 dimer interface [polypeptide binding]; other site 386585000289 interdomain contacts; other site 386585000290 partial ornithine binding site; other site 386585000291 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 386585000292 carnitine operon protein CaiE; Provisional; Region: PRK13627 386585000293 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 386585000294 putative trimer interface [polypeptide binding]; other site 386585000295 putative metal binding site [ion binding]; other site 386585000296 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 386585000297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 386585000298 substrate binding site [chemical binding]; other site 386585000299 oxyanion hole (OAH) forming residues; other site 386585000300 trimer interface [polypeptide binding]; other site 386585000301 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 386585000302 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 386585000303 acyl-activating enzyme (AAE) consensus motif; other site 386585000304 putative AMP binding site [chemical binding]; other site 386585000305 putative active site [active] 386585000306 putative CoA binding site [chemical binding]; other site 386585000307 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 386585000308 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 386585000309 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 386585000310 active site 386585000311 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 386585000312 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 386585000313 Ligand binding site [chemical binding]; other site 386585000314 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 386585000315 Electron transfer flavoprotein domain; Region: ETF; pfam01012 386585000316 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 386585000317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585000318 putative oxidoreductase FixC; Provisional; Region: PRK10157 386585000319 ferredoxin-like protein FixX; Provisional; Region: PRK15449 386585000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585000321 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 386585000322 putative substrate translocation pore; other site 386585000323 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 386585000324 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 386585000325 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 386585000326 TrkA-N domain; Region: TrkA_N; pfam02254 386585000327 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 386585000328 folate binding site [chemical binding]; other site 386585000329 NADP+ binding site [chemical binding]; other site 386585000330 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 386585000331 CcdB protein; Region: CcdB; pfam01845 386585000332 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 386585000333 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 386585000334 active site 386585000335 metal binding site [ion binding]; metal-binding site 386585000336 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 386585000337 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 386585000338 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 386585000339 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 386585000340 SurA N-terminal domain; Region: SurA_N; pfam09312 386585000341 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 386585000342 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 386585000343 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 386585000344 OstA-like protein; Region: OstA; pfam03968 386585000345 Organic solvent tolerance protein; Region: OstA_C; pfam04453 386585000346 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 386585000347 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 386585000348 putative metal binding site [ion binding]; other site 386585000349 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 386585000350 HSP70 interaction site [polypeptide binding]; other site 386585000351 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 386585000352 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 386585000353 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 386585000354 active site 386585000355 ATP-dependent helicase HepA; Validated; Region: PRK04914 386585000356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585000357 ATP binding site [chemical binding]; other site 386585000358 putative Mg++ binding site [ion binding]; other site 386585000359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585000360 nucleotide binding region [chemical binding]; other site 386585000361 ATP-binding site [chemical binding]; other site 386585000362 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 386585000363 DNA polymerase II; Reviewed; Region: PRK05762 386585000364 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 386585000365 active site 386585000366 catalytic site [active] 386585000367 substrate binding site [chemical binding]; other site 386585000368 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 386585000369 active site 386585000370 metal-binding site 386585000371 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 386585000372 intersubunit interface [polypeptide binding]; other site 386585000373 active site 386585000374 Zn2+ binding site [ion binding]; other site 386585000375 L-arabinose isomerase; Provisional; Region: PRK02929 386585000376 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 386585000377 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 386585000378 trimer interface [polypeptide binding]; other site 386585000379 putative substrate binding site [chemical binding]; other site 386585000380 putative metal binding site [ion binding]; other site 386585000381 ribulokinase; Provisional; Region: PRK04123 386585000382 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 386585000383 N- and C-terminal domain interface [polypeptide binding]; other site 386585000384 active site 386585000385 MgATP binding site [chemical binding]; other site 386585000386 catalytic site [active] 386585000387 metal binding site [ion binding]; metal-binding site 386585000388 carbohydrate binding site [chemical binding]; other site 386585000389 homodimer interface [polypeptide binding]; other site 386585000390 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 386585000391 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 386585000392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585000393 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585000394 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 386585000395 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 386585000396 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 386585000397 Walker A/P-loop; other site 386585000398 ATP binding site [chemical binding]; other site 386585000399 Q-loop/lid; other site 386585000400 ABC transporter signature motif; other site 386585000401 Walker B; other site 386585000402 D-loop; other site 386585000403 H-loop/switch region; other site 386585000404 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 386585000405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585000406 dimer interface [polypeptide binding]; other site 386585000407 conserved gate region; other site 386585000408 putative PBP binding loops; other site 386585000409 ABC-ATPase subunit interface; other site 386585000410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585000411 dimer interface [polypeptide binding]; other site 386585000412 conserved gate region; other site 386585000413 putative PBP binding loops; other site 386585000414 ABC-ATPase subunit interface; other site 386585000415 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 386585000416 transcriptional regulator SgrR; Provisional; Region: PRK13626 386585000417 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 386585000418 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 386585000419 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 386585000420 substrate binding site [chemical binding]; other site 386585000421 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 386585000422 substrate binding site [chemical binding]; other site 386585000423 ligand binding site [chemical binding]; other site 386585000424 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 386585000425 2-isopropylmalate synthase; Validated; Region: PRK00915 386585000426 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 386585000427 active site 386585000428 catalytic residues [active] 386585000429 metal binding site [ion binding]; metal-binding site 386585000430 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 386585000431 leu operon leader peptide; Provisional; Region: PRK09925 386585000432 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 386585000433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585000434 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 386585000435 putative substrate binding pocket [chemical binding]; other site 386585000436 putative dimerization interface [polypeptide binding]; other site 386585000437 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 386585000438 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 386585000439 PYR/PP interface [polypeptide binding]; other site 386585000440 dimer interface [polypeptide binding]; other site 386585000441 TPP binding site [chemical binding]; other site 386585000442 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 386585000443 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 386585000444 TPP-binding site [chemical binding]; other site 386585000445 dimer interface [polypeptide binding]; other site 386585000446 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 386585000447 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 386585000448 putative valine binding site [chemical binding]; other site 386585000449 dimer interface [polypeptide binding]; other site 386585000450 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 386585000451 similar to fruR leader peptide; similar to FRUL_ECOLI gi|1786267 (conserved in Escherichia coli K-12) 386585000452 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 386585000453 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585000454 DNA binding site [nucleotide binding] 386585000455 domain linker motif; other site 386585000456 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 386585000457 dimerization interface [polypeptide binding]; other site 386585000458 ligand binding site [chemical binding]; other site 386585000459 mraZ protein; Region: TIGR00242 386585000460 MraZ protein; Region: MraZ; pfam02381 386585000461 MraZ protein; Region: MraZ; pfam02381 386585000462 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 386585000463 cell division protein FtsL; Provisional; Region: PRK10772 386585000464 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 386585000465 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 386585000466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 386585000467 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 386585000468 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 386585000469 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 386585000470 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 386585000471 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 386585000472 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 386585000473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 386585000474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 386585000475 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 386585000476 Mg++ binding site [ion binding]; other site 386585000477 putative catalytic motif [active] 386585000478 putative substrate binding site [chemical binding]; other site 386585000479 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 386585000480 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 386585000481 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 386585000482 cell division protein FtsW; Provisional; Region: PRK10774 386585000483 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 386585000484 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 386585000485 active site 386585000486 homodimer interface [polypeptide binding]; other site 386585000487 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 386585000488 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 386585000489 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 386585000490 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 386585000491 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 386585000492 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 386585000493 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 386585000494 cell division protein FtsQ; Provisional; Region: PRK10775 386585000495 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 386585000496 Cell division protein FtsQ; Region: FtsQ; pfam03799 386585000497 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 386585000498 Cell division protein FtsA; Region: FtsA; pfam14450 386585000499 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585000500 Cell division protein FtsA; Region: FtsA; pfam14450 386585000501 cell division protein FtsZ; Validated; Region: PRK09330 386585000502 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 386585000503 nucleotide binding site [chemical binding]; other site 386585000504 SulA interaction site; other site 386585000505 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 386585000506 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 386585000507 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 386585000508 SecA regulator SecM; Provisional; Region: PRK02943 386585000509 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 386585000510 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 386585000511 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 386585000512 SEC-C motif; Region: SEC-C; pfam02810 386585000513 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 386585000514 active site 386585000515 8-oxo-dGMP binding site [chemical binding]; other site 386585000516 nudix motif; other site 386585000517 metal binding site [ion binding]; metal-binding site 386585000518 DNA gyrase inhibitor; Reviewed; Region: PRK00418 386585000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 386585000520 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 386585000521 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 386585000522 CoA-binding site [chemical binding]; other site 386585000523 ATP-binding [chemical binding]; other site 386585000524 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 386585000525 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 386585000526 active site 386585000527 type IV pilin biogenesis protein; Provisional; Region: PRK10573 386585000528 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 386585000529 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 386585000530 hypothetical protein; Provisional; Region: PRK10436 386585000531 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 386585000532 Walker A motif; other site 386585000533 ATP binding site [chemical binding]; other site 386585000534 Walker B motif; other site 386585000535 putative major pilin subunit; Provisional; Region: PRK10574 386585000536 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 386585000537 Pilin (bacterial filament); Region: Pilin; pfam00114 386585000538 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 386585000539 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 386585000540 dimerization interface [polypeptide binding]; other site 386585000541 active site 386585000542 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 386585000543 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 386585000544 amidase catalytic site [active] 386585000545 Zn binding residues [ion binding]; other site 386585000546 substrate binding site [chemical binding]; other site 386585000547 regulatory protein AmpE; Provisional; Region: PRK10987 386585000548 aromatic amino acid transporter; Provisional; Region: PRK10238 386585000549 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585000550 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 386585000551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585000552 DNA-binding site [nucleotide binding]; DNA binding site 386585000553 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585000554 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 386585000555 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 386585000556 dimer interface [polypeptide binding]; other site 386585000557 TPP-binding site [chemical binding]; other site 386585000558 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 386585000559 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 386585000560 E3 interaction surface; other site 386585000561 lipoyl attachment site [posttranslational modification]; other site 386585000562 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 386585000563 E3 interaction surface; other site 386585000564 lipoyl attachment site [posttranslational modification]; other site 386585000565 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 386585000566 E3 interaction surface; other site 386585000567 lipoyl attachment site [posttranslational modification]; other site 386585000568 e3 binding domain; Region: E3_binding; pfam02817 386585000569 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 386585000570 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 386585000571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585000572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585000573 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 386585000574 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 386585000575 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 386585000576 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 386585000577 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 386585000578 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 386585000579 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 386585000580 substrate binding site [chemical binding]; other site 386585000581 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 386585000582 substrate binding site [chemical binding]; other site 386585000583 ligand binding site [chemical binding]; other site 386585000584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 386585000585 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 386585000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585000587 S-adenosylmethionine binding site [chemical binding]; other site 386585000588 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 386585000589 multicopper oxidase; Provisional; Region: PRK10965 386585000590 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 386585000591 Domain 2 interface [polypeptide binding]; other site 386585000592 Domain 3 interface [polypeptide binding]; other site 386585000593 trinuclear Cu binding site [ion binding]; other site 386585000594 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 386585000595 Domain 1 interface [polypeptide binding]; other site 386585000596 Domain 3 interface [polypeptide binding]; other site 386585000597 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 386585000598 Domain 2 interface [polypeptide binding]; other site 386585000599 Domain 1 interface [polypeptide binding]; other site 386585000600 Type 1 (T1) Cu binding site [ion binding]; other site 386585000601 trinuclear Cu binding site [ion binding]; other site 386585000602 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 386585000603 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 386585000604 Trp docking motif [polypeptide binding]; other site 386585000605 putative active site [active] 386585000606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585000607 active site 386585000608 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 386585000609 active site clefts [active] 386585000610 zinc binding site [ion binding]; other site 386585000611 dimer interface [polypeptide binding]; other site 386585000612 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 386585000613 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 386585000614 Walker A/P-loop; other site 386585000615 ATP binding site [chemical binding]; other site 386585000616 Q-loop/lid; other site 386585000617 ABC transporter signature motif; other site 386585000618 Walker B; other site 386585000619 D-loop; other site 386585000620 H-loop/switch region; other site 386585000621 inner membrane transport permease; Provisional; Region: PRK15066 386585000622 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 386585000623 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 386585000624 active pocket/dimerization site; other site 386585000625 active site 386585000626 phosphorylation site [posttranslational modification] 386585000627 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 386585000628 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 386585000629 putative active site [active] 386585000630 putative metal binding site [ion binding]; other site 386585000631 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 386585000632 tetramerization interface [polypeptide binding]; other site 386585000633 active site 386585000634 Uncharacterized conserved protein [Function unknown]; Region: COG5464 386585000635 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 386585000636 Pantoate-beta-alanine ligase; Region: PanC; cd00560 386585000637 active site 386585000638 ATP-binding site [chemical binding]; other site 386585000639 pantoate-binding site; other site 386585000640 HXXH motif; other site 386585000641 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 386585000642 oligomerization interface [polypeptide binding]; other site 386585000643 active site 386585000644 metal binding site [ion binding]; metal-binding site 386585000645 Fimbrial protein; Region: Fimbrial; cl01416 386585000646 putative fimbrial protein StaF; Provisional; Region: PRK15262 386585000647 putative fimbrial protein StaE; Provisional; Region: PRK15263 386585000648 Fimbrial protein; Region: Fimbrial; cl01416 386585000649 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 386585000650 PapC N-terminal domain; Region: PapC_N; pfam13954 386585000651 Outer membrane usher protein; Region: Usher; pfam00577 386585000652 PapC C-terminal domain; Region: PapC_C; pfam13953 386585000653 putative chaperone protein EcpD; Provisional; Region: PRK09926 386585000654 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585000655 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585000656 Fimbrial protein; Region: Fimbrial; cl01416 386585000657 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 386585000658 catalytic center binding site [active] 386585000659 ATP binding site [chemical binding]; other site 386585000660 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 386585000661 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 386585000662 active site 386585000663 NTP binding site [chemical binding]; other site 386585000664 metal binding triad [ion binding]; metal-binding site 386585000665 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 386585000666 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 386585000667 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 386585000668 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 386585000669 active site 386585000670 nucleotide binding site [chemical binding]; other site 386585000671 HIGH motif; other site 386585000672 KMSKS motif; other site 386585000673 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 386585000674 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 386585000675 2'-5' RNA ligase; Provisional; Region: PRK15124 386585000676 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 386585000677 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 386585000678 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 386585000679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585000680 ATP binding site [chemical binding]; other site 386585000681 putative Mg++ binding site [ion binding]; other site 386585000682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585000683 nucleotide binding region [chemical binding]; other site 386585000684 ATP-binding site [chemical binding]; other site 386585000685 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 386585000686 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 386585000687 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 386585000688 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 386585000689 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 386585000690 Transglycosylase; Region: Transgly; pfam00912 386585000691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 386585000692 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 386585000693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585000694 N-terminal plug; other site 386585000695 ligand-binding site [chemical binding]; other site 386585000696 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 386585000697 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 386585000698 Walker A/P-loop; other site 386585000699 ATP binding site [chemical binding]; other site 386585000700 Q-loop/lid; other site 386585000701 ABC transporter signature motif; other site 386585000702 Walker B; other site 386585000703 D-loop; other site 386585000704 H-loop/switch region; other site 386585000705 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 386585000706 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 386585000707 siderophore binding site; other site 386585000708 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 386585000709 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585000710 ABC-ATPase subunit interface; other site 386585000711 dimer interface [polypeptide binding]; other site 386585000712 putative PBP binding regions; other site 386585000713 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585000714 ABC-ATPase subunit interface; other site 386585000715 dimer interface [polypeptide binding]; other site 386585000716 putative PBP binding regions; other site 386585000717 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 386585000718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585000719 inhibitor-cofactor binding pocket; inhibition site 386585000720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585000721 catalytic residue [active] 386585000722 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 386585000723 Cl- selectivity filter; other site 386585000724 Cl- binding residues [ion binding]; other site 386585000725 pore gating glutamate residue; other site 386585000726 dimer interface [polypeptide binding]; other site 386585000727 H+/Cl- coupling transport residue; other site 386585000728 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 386585000729 hypothetical protein; Provisional; Region: PRK10578 386585000730 UPF0126 domain; Region: UPF0126; pfam03458 386585000731 UPF0126 domain; Region: UPF0126; pfam03458 386585000732 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 386585000733 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 386585000734 cobalamin binding residues [chemical binding]; other site 386585000735 putative BtuC binding residues; other site 386585000736 dimer interface [polypeptide binding]; other site 386585000737 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 386585000738 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 386585000739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 386585000740 Zn2+ binding site [ion binding]; other site 386585000741 Mg2+ binding site [ion binding]; other site 386585000742 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 386585000743 serine endoprotease; Provisional; Region: PRK10942 386585000744 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 386585000745 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 386585000746 protein binding site [polypeptide binding]; other site 386585000747 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 386585000748 protein binding site [polypeptide binding]; other site 386585000749 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 386585000750 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 386585000751 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 386585000752 hypothetical protein; Provisional; Region: PRK13677 386585000753 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 386585000754 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 386585000755 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 386585000756 trimer interface [polypeptide binding]; other site 386585000757 active site 386585000758 substrate binding site [chemical binding]; other site 386585000759 CoA binding site [chemical binding]; other site 386585000760 PII uridylyl-transferase; Provisional; Region: PRK05007 386585000761 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 386585000762 metal binding triad; other site 386585000763 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 386585000764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 386585000765 Zn2+ binding site [ion binding]; other site 386585000766 Mg2+ binding site [ion binding]; other site 386585000767 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 386585000768 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 386585000769 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 386585000770 active site 386585000771 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 386585000772 rRNA interaction site [nucleotide binding]; other site 386585000773 S8 interaction site; other site 386585000774 putative laminin-1 binding site; other site 386585000775 elongation factor Ts; Provisional; Region: tsf; PRK09377 386585000776 UBA/TS-N domain; Region: UBA; pfam00627 386585000777 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 386585000778 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 386585000779 putative nucleotide binding site [chemical binding]; other site 386585000780 uridine monophosphate binding site [chemical binding]; other site 386585000781 homohexameric interface [polypeptide binding]; other site 386585000782 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 386585000783 hinge region; other site 386585000784 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 386585000785 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 386585000786 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 386585000787 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 386585000788 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 386585000789 active site 386585000790 dimer interface [polypeptide binding]; other site 386585000791 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 386585000792 zinc metallopeptidase RseP; Provisional; Region: PRK10779 386585000793 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 386585000794 active site 386585000795 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 386585000796 protein binding site [polypeptide binding]; other site 386585000797 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 386585000798 protein binding site [polypeptide binding]; other site 386585000799 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 386585000800 putative substrate binding region [chemical binding]; other site 386585000801 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 386585000802 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585000803 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585000804 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585000805 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585000806 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585000807 Surface antigen; Region: Bac_surface_Ag; pfam01103 386585000808 periplasmic chaperone; Provisional; Region: PRK10780 386585000809 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 386585000810 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 386585000811 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 386585000812 trimer interface [polypeptide binding]; other site 386585000813 active site 386585000814 UDP-GlcNAc binding site [chemical binding]; other site 386585000815 lipid binding site [chemical binding]; lipid-binding site 386585000816 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 386585000817 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 386585000818 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 386585000819 active site 386585000820 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 386585000821 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 386585000822 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 386585000823 RNA/DNA hybrid binding site [nucleotide binding]; other site 386585000824 active site 386585000825 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 386585000826 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 386585000827 putative active site [active] 386585000828 putative PHP Thumb interface [polypeptide binding]; other site 386585000829 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 386585000830 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 386585000831 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 386585000832 generic binding surface II; other site 386585000833 generic binding surface I; other site 386585000834 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 386585000835 lysine decarboxylase LdcC; Provisional; Region: PRK15399 386585000836 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 386585000837 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 386585000838 homodimer interface [polypeptide binding]; other site 386585000839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585000840 catalytic residue [active] 386585000841 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 386585000842 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 386585000843 putative metal binding site [ion binding]; other site 386585000844 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 386585000845 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 386585000846 Ligand Binding Site [chemical binding]; other site 386585000847 TilS substrate binding domain; Region: TilS; pfam09179 386585000848 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 386585000849 Rho-binding antiterminator; Provisional; Region: PRK11625 386585000850 hypothetical protein; Provisional; Region: PRK04964 386585000851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 386585000852 hypothetical protein; Provisional; Region: PRK09256 386585000853 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 386585000854 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 386585000855 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 386585000856 hypothetical protein; Provisional; Region: PRK11479 386585000857 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585000858 prolyl-tRNA synthetase; Provisional; Region: PRK09194 386585000859 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 386585000860 dimer interface [polypeptide binding]; other site 386585000861 motif 1; other site 386585000862 active site 386585000863 motif 2; other site 386585000864 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 386585000865 putative deacylase active site [active] 386585000866 motif 3; other site 386585000867 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 386585000868 anticodon binding site; other site 386585000869 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 386585000870 homodimer interaction site [polypeptide binding]; other site 386585000871 cofactor binding site; other site 386585000872 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 386585000873 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 386585000874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585000875 dimer interface [polypeptide binding]; other site 386585000876 conserved gate region; other site 386585000877 putative PBP binding loops; other site 386585000878 ABC-ATPase subunit interface; other site 386585000879 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 386585000880 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 386585000881 Walker A/P-loop; other site 386585000882 ATP binding site [chemical binding]; other site 386585000883 Q-loop/lid; other site 386585000884 ABC transporter signature motif; other site 386585000885 Walker B; other site 386585000886 D-loop; other site 386585000887 H-loop/switch region; other site 386585000888 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 386585000889 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 386585000890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585000891 active site 386585000892 motif I; other site 386585000893 motif II; other site 386585000894 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585000895 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585000896 active site 386585000897 catalytic tetrad [active] 386585000898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585000899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585000900 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 386585000901 putative effector binding pocket; other site 386585000902 dimerization interface [polypeptide binding]; other site 386585000903 hypothetical protein; Provisional; Region: PRK05421 386585000904 putative catalytic site [active] 386585000905 putative metal binding site [ion binding]; other site 386585000906 putative phosphate binding site [ion binding]; other site 386585000907 putative catalytic site [active] 386585000908 putative phosphate binding site [ion binding]; other site 386585000909 putative metal binding site [ion binding]; other site 386585000910 Methyltransferase domain; Region: Methyltransf_31; pfam13847 386585000911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585000912 S-adenosylmethionine binding site [chemical binding]; other site 386585000913 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 386585000914 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585000915 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585000916 catalytic residue [active] 386585000917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585000918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585000919 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 386585000920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585000921 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 386585000922 RNA/DNA hybrid binding site [nucleotide binding]; other site 386585000923 active site 386585000924 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 386585000925 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 386585000926 active site 386585000927 catalytic site [active] 386585000928 substrate binding site [chemical binding]; other site 386585000929 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 386585000930 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 386585000931 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 386585000932 ImpA domain protein; Region: DUF3702; pfam12486 386585000933 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 386585000934 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 386585000935 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 386585000936 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 386585000937 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 386585000938 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 386585000939 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 386585000940 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 386585000941 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 386585000942 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 386585000943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585000944 Walker A motif; other site 386585000945 ATP binding site [chemical binding]; other site 386585000946 Walker B motif; other site 386585000947 arginine finger; other site 386585000948 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 386585000949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585000950 Walker A motif; other site 386585000951 ATP binding site [chemical binding]; other site 386585000952 Walker B motif; other site 386585000953 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 386585000954 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 386585000955 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 386585000956 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 386585000957 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 386585000958 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 386585000959 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 386585000960 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 386585000961 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 386585000962 Protein of unknown function (DUF877); Region: DUF877; cl05484 386585000963 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 386585000964 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 386585000965 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 386585000966 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 386585000967 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 386585000968 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 386585000969 PAAR motif; Region: PAAR_motif; cl15808 386585000970 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585000971 RHS Repeat; Region: RHS_repeat; pfam05593 386585000972 RHS Repeat; Region: RHS_repeat; pfam05593 386585000973 RHS Repeat; Region: RHS_repeat; pfam05593 386585000974 RHS Repeat; Region: RHS_repeat; pfam05593 386585000975 RHS Repeat; Region: RHS_repeat; pfam05593 386585000976 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585000977 RHS Repeat; Region: RHS_repeat; pfam05593 386585000978 RHS Repeat; Region: RHS_repeat; pfam05593 386585000979 RHS protein; Region: RHS; pfam03527 386585000980 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585000981 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 386585000982 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 386585000983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 386585000984 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585000985 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585000986 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585000987 Erythromycin esterase; Region: Erythro_esteras; cl17110 386585000988 RHS protein; Region: RHS; pfam03527 386585000989 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585000990 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 386585000991 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 386585000992 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585000993 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585000994 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 386585000995 putative active site [active] 386585000996 catalytic triad [active] 386585000997 dimer interface [polypeptide binding]; other site 386585000998 multimer interface [polypeptide binding]; other site 386585000999 C-lysozyme inhibitor; Provisional; Region: PRK09993 386585001000 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 386585001001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 386585001002 active site 386585001003 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 386585001004 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 386585001005 dimer interface [polypeptide binding]; other site 386585001006 active site 386585001007 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 386585001008 putative active site [active] 386585001009 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 386585001010 putative dimer interface [polypeptide binding]; other site 386585001011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 386585001012 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 386585001013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 386585001014 RelB antitoxin; Region: RelB; pfam04221 386585001015 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585001016 NlpC/P60 family; Region: NLPC_P60; pfam00877 386585001017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 386585001018 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 386585001019 hypothetical protein; Validated; Region: PRK06778 386585001020 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585001021 ligand binding site [chemical binding]; other site 386585001022 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 386585001023 active site 386585001024 DNA polymerase IV; Validated; Region: PRK02406 386585001025 DNA binding site [nucleotide binding] 386585001026 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 386585001027 putative toxin YafO; Provisional; Region: PRK09885 386585001028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 386585001029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585001030 Coenzyme A binding pocket [chemical binding]; other site 386585001031 Uncharacterized conserved protein [Function unknown]; Region: RtcB; cl17455 386585001032 RF-1 domain; Region: RF-1; cl17422 386585001033 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 386585001034 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 386585001035 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 386585001036 metal binding site [ion binding]; metal-binding site 386585001037 dimer interface [polypeptide binding]; other site 386585001038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585001039 active site 386585001040 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585001041 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 386585001042 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 386585001043 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 386585001044 trimer interface [polypeptide binding]; other site 386585001045 eyelet of channel; other site 386585001046 gamma-glutamyl kinase; Provisional; Region: PRK05429 386585001047 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 386585001048 nucleotide binding site [chemical binding]; other site 386585001049 homotetrameric interface [polypeptide binding]; other site 386585001050 putative phosphate binding site [ion binding]; other site 386585001051 putative allosteric binding site; other site 386585001052 PUA domain; Region: PUA; pfam01472 386585001053 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 386585001054 putative catalytic cysteine [active] 386585001055 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585001056 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 386585001057 Int/Topo IB signature motif; other site 386585001058 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 386585001059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585001060 non-specific DNA binding site [nucleotide binding]; other site 386585001061 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 386585001062 salt bridge; other site 386585001063 sequence-specific DNA binding site [nucleotide binding]; other site 386585001064 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585001065 Catalytic site [active] 386585001066 Cro; Region: Cro; pfam09048 386585001067 Bacteriophage CII protein; Region: Phage_CII; pfam05269 386585001068 similar to Bacteriophage lambda 386585001069 similar to Bacteriophage lambda 386585001070 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 386585001071 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 386585001072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 386585001073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 386585001074 catalytic residues [active] 386585001075 catalytic nucleophile [active] 386585001076 Presynaptic Site I dimer interface [polypeptide binding]; other site 386585001077 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 386585001078 Synaptic Flat tetramer interface [polypeptide binding]; other site 386585001079 Synaptic Site I dimer interface [polypeptide binding]; other site 386585001080 DNA binding site [nucleotide binding] 386585001081 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 386585001082 DNA-binding interface [nucleotide binding]; DNA binding site 386585001083 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 386585001084 GIY-YIG motif/motif A; other site 386585001085 putative active site [active] 386585001086 putative metal binding site [ion binding]; other site 386585001087 transcriptional regulator YdeO; Provisional; Region: PRK09940 386585001088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001090 Integrase core domain; Region: rve; pfam00665 386585001091 Integrase core domain; Region: rve_3; pfam13683 386585001092 integrase; Provisional; Region: PRK09692 386585001093 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585001094 active site 386585001095 Int/Topo IB signature motif; other site 386585001096 Restriction endonuclease; Region: Mrr_cat; cl19295 386585001097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001098 Walker A/P-loop; other site 386585001099 ATP binding site [chemical binding]; other site 386585001100 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 386585001101 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 386585001102 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 386585001103 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 386585001104 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 386585001105 Ash protein family; Region: Phage_ASH; pfam10554 386585001106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 386585001107 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 386585001108 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 386585001109 active site 386585001110 metal binding site [ion binding]; metal-binding site 386585001111 interdomain interaction site; other site 386585001112 D5 N terminal like; Region: D5_N; smart00885 386585001113 Phage associated DNA primase [General function prediction only]; Region: COG3378 386585001114 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 386585001115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585001116 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 386585001117 putative effector binding pocket; other site 386585001118 putative dimerization interface [polypeptide binding]; other site 386585001119 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 386585001120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585001121 NAD(P) binding site [chemical binding]; other site 386585001122 active site 386585001123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585001124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585001125 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 386585001126 putative effector binding pocket; other site 386585001127 putative dimerization interface [polypeptide binding]; other site 386585001128 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 386585001129 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585001130 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 386585001131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001132 putative substrate translocation pore; other site 386585001133 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 386585001134 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 386585001135 XdhC Rossmann domain; Region: XdhC_C; pfam13478 386585001136 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 386585001137 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 386585001138 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 386585001139 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 386585001140 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 386585001141 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 386585001142 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 386585001143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585001144 catalytic loop [active] 386585001145 iron binding site [ion binding]; other site 386585001146 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 386585001147 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 386585001148 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 386585001149 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 386585001150 Outer membrane usher protein; Region: Usher; pfam00577 386585001151 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 386585001152 putative fimbrial protein TcfA; Provisional; Region: PRK15308 386585001153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585001154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585001155 DNA binding residues [nucleotide binding] 386585001156 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 386585001157 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 386585001158 Transposase; Region: HTH_Tnp_1; pfam01527 386585001159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585001160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585001161 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585001162 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585001163 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585001164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585001165 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585001166 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585001167 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585001168 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 386585001169 putative active site [active] 386585001170 putative FMN binding site [chemical binding]; other site 386585001171 putative substrate binding site [chemical binding]; other site 386585001172 putative catalytic residue [active] 386585001173 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 386585001174 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 386585001175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585001176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585001177 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 386585001178 putative effector binding pocket; other site 386585001179 putative dimerization interface [polypeptide binding]; other site 386585001180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585001181 active site 386585001182 catalytic tetrad [active] 386585001183 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 386585001184 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585001185 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585001186 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585001187 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585001188 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 386585001189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001191 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 386585001192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585001193 active site 386585001194 catalytic tetrad [active] 386585001195 Predicted membrane protein [Function unknown]; Region: COG3059 386585001196 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585001197 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 386585001198 Squalene epoxidase; Region: SE; cl17314 386585001199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585001200 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 386585001201 Cupin; Region: Cupin_6; pfam12852 386585001202 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 386585001203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001205 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 386585001206 Cysteine-rich domain; Region: CCG; pfam02754 386585001207 Cysteine-rich domain; Region: CCG; pfam02754 386585001208 iron-sulfur cluster-binding protein; Region: TIGR00273 386585001209 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 386585001210 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 386585001211 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 386585001212 Uncharacterized conserved protein [Function unknown]; Region: COG1556 386585001213 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585001214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 386585001215 similar to invertase; contains frameshift 386585001216 choline dehydrogenase; Validated; Region: PRK02106 386585001217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585001218 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 386585001219 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 386585001220 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 386585001221 tetrameric interface [polypeptide binding]; other site 386585001222 NAD binding site [chemical binding]; other site 386585001223 catalytic residues [active] 386585001224 transcriptional regulator BetI; Validated; Region: PRK00767 386585001225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585001226 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 386585001227 choline transport protein BetT; Provisional; Region: PRK09928 386585001228 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 386585001229 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 386585001230 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585001231 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585001232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585001233 DNA binding residues [nucleotide binding] 386585001234 dimerization interface [polypeptide binding]; other site 386585001235 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585001236 similar to YahB; contains frameshift 386585001237 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 386585001238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 386585001239 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 386585001240 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 386585001241 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 386585001242 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 386585001243 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 386585001244 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 386585001245 CoA binding domain; Region: CoA_binding; pfam02629 386585001246 CoA-ligase; Region: Ligase_CoA; pfam00549 386585001247 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 386585001248 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 386585001249 putative substrate binding site [chemical binding]; other site 386585001250 nucleotide binding site [chemical binding]; other site 386585001251 nucleotide binding site [chemical binding]; other site 386585001252 homodimer interface [polypeptide binding]; other site 386585001253 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 386585001254 cytosine deaminase; Provisional; Region: PRK05985 386585001255 active site 386585001256 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 386585001257 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 386585001258 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 386585001259 ligand binding site [chemical binding]; other site 386585001260 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 386585001261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001262 Walker A/P-loop; other site 386585001263 ATP binding site [chemical binding]; other site 386585001264 Q-loop/lid; other site 386585001265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001266 Q-loop/lid; other site 386585001267 ABC transporter signature motif; other site 386585001268 Walker B; other site 386585001269 D-loop; other site 386585001270 H-loop/switch region; other site 386585001271 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 386585001272 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585001273 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585001274 TM-ABC transporter signature motif; other site 386585001275 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585001276 TM-ABC transporter signature motif; other site 386585001277 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 386585001278 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 386585001279 putative NAD(P) binding site [chemical binding]; other site 386585001280 putative substrate binding site [chemical binding]; other site 386585001281 catalytic Zn binding site [ion binding]; other site 386585001282 structural Zn binding site [ion binding]; other site 386585001283 dimer interface [polypeptide binding]; other site 386585001284 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 386585001285 hypothetical protein; Provisional; Region: PRK09929 386585001286 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 386585001287 Propionate catabolism activator; Region: PrpR_N; pfam06506 386585001288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585001289 Walker A motif; other site 386585001290 ATP binding site [chemical binding]; other site 386585001291 Walker B motif; other site 386585001292 arginine finger; other site 386585001293 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 386585001294 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 386585001295 tetramer interface [polypeptide binding]; other site 386585001296 active site 386585001297 Mg2+/Mn2+ binding site [ion binding]; other site 386585001298 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 386585001299 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 386585001300 dimer interface [polypeptide binding]; other site 386585001301 active site 386585001302 citrylCoA binding site [chemical binding]; other site 386585001303 oxalacetate/citrate binding site [chemical binding]; other site 386585001304 coenzyme A binding site [chemical binding]; other site 386585001305 catalytic triad [active] 386585001306 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 386585001307 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 386585001308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 386585001309 acyl-activating enzyme (AAE) consensus motif; other site 386585001310 AMP binding site [chemical binding]; other site 386585001311 active site 386585001312 CoA binding site [chemical binding]; other site 386585001313 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 386585001314 Na binding site [ion binding]; other site 386585001315 putative substrate binding site [chemical binding]; other site 386585001316 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 386585001317 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 386585001318 active site 386585001319 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 386585001320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585001321 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 386585001322 dimerization interface [polypeptide binding]; other site 386585001323 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 386585001324 active site clefts [active] 386585001325 zinc binding site [ion binding]; other site 386585001326 dimer interface [polypeptide binding]; other site 386585001327 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 386585001328 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 386585001329 oligomer interface [polypeptide binding]; other site 386585001330 active site 386585001331 putative cyanate transporter; Provisional; Region: cynX; PRK09705 386585001332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001333 putative substrate translocation pore; other site 386585001334 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 386585001335 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 386585001336 active site 386585001337 substrate binding site [chemical binding]; other site 386585001338 trimer interface [polypeptide binding]; other site 386585001339 CoA binding site [chemical binding]; other site 386585001340 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 386585001341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001342 putative substrate translocation pore; other site 386585001343 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 386585001344 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 386585001345 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 386585001346 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 386585001347 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 386585001348 lac repressor; Reviewed; Region: lacI; PRK09526 386585001349 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585001350 DNA binding site [nucleotide binding] 386585001351 domain linker motif; other site 386585001352 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 386585001353 ligand binding site [chemical binding]; other site 386585001354 dimerization interface (open form) [polypeptide binding]; other site 386585001355 dimerization interface (closed form) [polypeptide binding]; other site 386585001356 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 386585001357 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 386585001358 conserved cys residue [active] 386585001359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585001361 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 386585001362 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 386585001363 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 386585001364 Bacterial transcriptional regulator; Region: IclR; pfam01614 386585001365 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 386585001366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585001367 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 386585001368 putative active site [active] 386585001369 Fe(II) binding site [ion binding]; other site 386585001370 putative dimer interface [polypeptide binding]; other site 386585001371 putative tetramer interface [polypeptide binding]; other site 386585001372 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 386585001373 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585001374 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 386585001375 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 386585001376 acetaldehyde dehydrogenase; Validated; Region: PRK08300 386585001377 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 386585001378 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 386585001379 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 386585001380 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 386585001381 active site 386585001382 catalytic residues [active] 386585001383 metal binding site [ion binding]; metal-binding site 386585001384 DmpG-like communication domain; Region: DmpG_comm; pfam07836 386585001385 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 386585001386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001387 putative substrate translocation pore; other site 386585001388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 386585001389 Predicted esterase [General function prediction only]; Region: COG0627 386585001390 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 386585001391 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 386585001392 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 386585001393 substrate binding site [chemical binding]; other site 386585001394 catalytic Zn binding site [ion binding]; other site 386585001395 NAD binding site [chemical binding]; other site 386585001396 structural Zn binding site [ion binding]; other site 386585001397 dimer interface [polypeptide binding]; other site 386585001398 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 386585001399 putative metal binding site [ion binding]; other site 386585001400 putative homodimer interface [polypeptide binding]; other site 386585001401 putative homotetramer interface [polypeptide binding]; other site 386585001402 putative homodimer-homodimer interface [polypeptide binding]; other site 386585001403 putative allosteric switch controlling residues; other site 386585001404 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 386585001405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001406 Walker A/P-loop; other site 386585001407 ATP binding site [chemical binding]; other site 386585001408 Q-loop/lid; other site 386585001409 ABC transporter signature motif; other site 386585001410 Walker B; other site 386585001411 D-loop; other site 386585001412 H-loop/switch region; other site 386585001413 TOBE domain; Region: TOBE_2; pfam08402 386585001414 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 386585001415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585001416 dimer interface [polypeptide binding]; other site 386585001417 conserved gate region; other site 386585001418 putative PBP binding loops; other site 386585001419 ABC-ATPase subunit interface; other site 386585001420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585001421 dimer interface [polypeptide binding]; other site 386585001422 conserved gate region; other site 386585001423 putative PBP binding loops; other site 386585001424 ABC-ATPase subunit interface; other site 386585001425 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 386585001426 regulatory protein UhpC; Provisional; Region: PRK11663 386585001427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001428 putative substrate translocation pore; other site 386585001429 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 386585001430 MASE1; Region: MASE1; pfam05231 386585001431 Histidine kinase; Region: HisKA_3; pfam07730 386585001432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585001433 ATP binding site [chemical binding]; other site 386585001434 Mg2+ binding site [ion binding]; other site 386585001435 G-X-G motif; other site 386585001436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585001437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585001438 active site 386585001439 phosphorylation site [posttranslational modification] 386585001440 intermolecular recognition site; other site 386585001441 dimerization interface [polypeptide binding]; other site 386585001442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585001443 DNA binding residues [nucleotide binding] 386585001444 dimerization interface [polypeptide binding]; other site 386585001445 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 386585001446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585001447 substrate binding pocket [chemical binding]; other site 386585001448 membrane-bound complex binding site; other site 386585001449 hinge residues; other site 386585001450 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 386585001451 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 386585001452 Walker A/P-loop; other site 386585001453 ATP binding site [chemical binding]; other site 386585001454 Q-loop/lid; other site 386585001455 ABC transporter signature motif; other site 386585001456 Walker B; other site 386585001457 D-loop; other site 386585001458 H-loop/switch region; other site 386585001459 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 386585001460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585001461 dimer interface [polypeptide binding]; other site 386585001462 conserved gate region; other site 386585001463 putative PBP binding loops; other site 386585001464 ABC-ATPase subunit interface; other site 386585001465 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 386585001466 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 386585001467 active site 386585001468 iron coordination sites [ion binding]; other site 386585001469 substrate binding pocket [chemical binding]; other site 386585001470 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 386585001471 dimer interface [polypeptide binding]; other site 386585001472 active site 386585001473 Schiff base residues; other site 386585001474 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 386585001475 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585001476 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585001477 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 386585001478 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 386585001479 microcin B17 transporter; Reviewed; Region: PRK11098 386585001480 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 386585001481 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 386585001482 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 386585001483 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 386585001484 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 386585001485 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 386585001486 anti-RssB factor; Provisional; Region: PRK10244 386585001487 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 386585001488 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 386585001489 dimer interface [polypeptide binding]; other site 386585001490 active site 386585001491 hypothetical protein; Provisional; Region: PRK11505 386585001492 psiF repeat; Region: PsiF_repeat; pfam07769 386585001493 psiF repeat; Region: PsiF_repeat; pfam07769 386585001494 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 386585001495 MASE2 domain; Region: MASE2; pfam05230 386585001496 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585001497 metal binding site [ion binding]; metal-binding site 386585001498 active site 386585001499 I-site; other site 386585001500 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 386585001501 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 386585001502 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 386585001503 hypothetical protein; Validated; Region: PRK00124 386585001504 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 386585001505 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 386585001506 ADP binding site [chemical binding]; other site 386585001507 magnesium binding site [ion binding]; other site 386585001508 putative shikimate binding site; other site 386585001509 hypothetical protein; Provisional; Region: PRK10380 386585001510 hypothetical protein; Provisional; Region: PRK10481 386585001511 hypothetical protein; Provisional; Region: PRK10579 386585001512 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 386585001513 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 386585001514 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 386585001515 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 386585001516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585001517 nucleotide binding site [chemical binding]; other site 386585001518 MFS transport protein AraJ; Provisional; Region: PRK10091 386585001519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001520 putative substrate translocation pore; other site 386585001521 exonuclease subunit SbcC; Provisional; Region: PRK10246 386585001522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001523 Walker A/P-loop; other site 386585001524 ATP binding site [chemical binding]; other site 386585001525 Q-loop/lid; other site 386585001526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001527 ABC transporter signature motif; other site 386585001528 Walker B; other site 386585001529 D-loop; other site 386585001530 H-loop/switch region; other site 386585001531 exonuclease subunit SbcD; Provisional; Region: PRK10966 386585001532 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 386585001533 active site 386585001534 metal binding site [ion binding]; metal-binding site 386585001535 DNA binding site [nucleotide binding] 386585001536 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 386585001537 transcriptional regulator PhoB; Provisional; Region: PRK10161 386585001538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585001539 active site 386585001540 phosphorylation site [posttranslational modification] 386585001541 intermolecular recognition site; other site 386585001542 dimerization interface [polypeptide binding]; other site 386585001543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585001544 DNA binding site [nucleotide binding] 386585001545 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 386585001546 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 386585001547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585001548 putative active site [active] 386585001549 heme pocket [chemical binding]; other site 386585001550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585001551 dimer interface [polypeptide binding]; other site 386585001552 phosphorylation site [posttranslational modification] 386585001553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585001554 ATP binding site [chemical binding]; other site 386585001555 Mg2+ binding site [ion binding]; other site 386585001556 G-X-G motif; other site 386585001557 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 386585001558 putative proline-specific permease; Provisional; Region: proY; PRK10580 386585001559 Spore germination protein; Region: Spore_permease; cl17796 386585001560 maltodextrin glucosidase; Provisional; Region: PRK10785 386585001561 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 386585001562 homodimer interface [polypeptide binding]; other site 386585001563 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 386585001564 active site 386585001565 homodimer interface [polypeptide binding]; other site 386585001566 catalytic site [active] 386585001567 ATP-dependent protease La; Region: lon; TIGR00763 386585001568 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 386585001569 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 386585001570 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 386585001571 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 386585001572 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 386585001573 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 386585001574 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 386585001575 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 386585001576 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 386585001577 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 386585001578 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 386585001579 Protein export membrane protein; Region: SecD_SecF; pfam02355 386585001580 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 386585001581 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 386585001582 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585001583 active site 386585001584 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 386585001585 hypothetical protein; Provisional; Region: PRK11530 386585001586 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 386585001587 ATP cone domain; Region: ATP-cone; pfam03477 386585001588 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 386585001589 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 386585001590 catalytic motif [active] 386585001591 Zn binding site [ion binding]; other site 386585001592 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 386585001593 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 386585001594 homopentamer interface [polypeptide binding]; other site 386585001595 active site 386585001596 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 386585001597 thiamine monophosphate kinase; Provisional; Region: PRK05731 386585001598 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 386585001599 ATP binding site [chemical binding]; other site 386585001600 dimerization interface [polypeptide binding]; other site 386585001601 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 386585001602 tetramer interfaces [polypeptide binding]; other site 386585001603 binuclear metal-binding site [ion binding]; other site 386585001604 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 386585001605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585001606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585001607 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585001608 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585001609 active site 386585001610 catalytic tetrad [active] 386585001611 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 386585001612 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 386585001613 TPP-binding site; other site 386585001614 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 386585001615 PYR/PP interface [polypeptide binding]; other site 386585001616 dimer interface [polypeptide binding]; other site 386585001617 TPP binding site [chemical binding]; other site 386585001618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 386585001619 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 386585001620 substrate binding pocket [chemical binding]; other site 386585001621 chain length determination region; other site 386585001622 active site lid residues [active] 386585001623 substrate-Mg2+ binding site; other site 386585001624 catalytic residues [active] 386585001625 aspartate-rich region 1; other site 386585001626 aspartate-rich region 2; other site 386585001627 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 386585001628 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 386585001629 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 386585001630 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 386585001631 Ligand Binding Site [chemical binding]; other site 386585001632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 386585001633 active site residue [active] 386585001634 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 386585001635 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 386585001636 conserved cys residue [active] 386585001637 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 386585001638 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 386585001639 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 386585001640 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 386585001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585001643 putative substrate translocation pore; other site 386585001644 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 386585001645 putative active site [active] 386585001646 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 386585001647 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 386585001648 Subunit I/III interface [polypeptide binding]; other site 386585001649 Subunit III/IV interface [polypeptide binding]; other site 386585001650 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 386585001651 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 386585001652 D-pathway; other site 386585001653 Putative ubiquinol binding site [chemical binding]; other site 386585001654 Low-spin heme (heme b) binding site [chemical binding]; other site 386585001655 Putative water exit pathway; other site 386585001656 Binuclear center (heme o3/CuB) [ion binding]; other site 386585001657 K-pathway; other site 386585001658 Putative proton exit pathway; other site 386585001659 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 386585001660 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 386585001661 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 386585001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001663 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585001664 putative substrate translocation pore; other site 386585001665 hypothetical protein; Provisional; Region: PRK11627 386585001666 transcriptional regulator BolA; Provisional; Region: PRK11628 386585001667 trigger factor; Provisional; Region: tig; PRK01490 386585001668 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 386585001669 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 386585001670 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 386585001671 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 386585001672 oligomer interface [polypeptide binding]; other site 386585001673 active site residues [active] 386585001674 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 386585001675 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 386585001676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585001677 Walker A motif; other site 386585001678 ATP binding site [chemical binding]; other site 386585001679 Walker B motif; other site 386585001680 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 386585001681 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 386585001682 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 386585001683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585001684 Walker A motif; other site 386585001685 ATP binding site [chemical binding]; other site 386585001686 Walker B motif; other site 386585001687 arginine finger; other site 386585001688 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 386585001689 histone-like DNA-binding protein HU; Region: HU; cd13831 386585001690 dimer interface [polypeptide binding]; other site 386585001691 DNA binding site [nucleotide binding] 386585001692 periplasmic folding chaperone; Provisional; Region: PRK10788 386585001693 SurA N-terminal domain; Region: SurA_N_3; cl07813 386585001694 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 386585001695 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 386585001696 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 386585001697 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 386585001698 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 386585001699 active site 386585001700 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 386585001701 Ligand Binding Site [chemical binding]; other site 386585001702 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 386585001703 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 386585001704 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 386585001705 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 386585001706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585001707 active site 386585001708 motif I; other site 386585001709 motif II; other site 386585001710 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585001711 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 386585001712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585001713 putative DNA binding site [nucleotide binding]; other site 386585001714 putative Zn2+ binding site [ion binding]; other site 386585001715 AsnC family; Region: AsnC_trans_reg; pfam01037 386585001716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585001717 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 386585001718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001719 Walker A/P-loop; other site 386585001720 ATP binding site [chemical binding]; other site 386585001721 Q-loop/lid; other site 386585001722 ABC transporter signature motif; other site 386585001723 Walker B; other site 386585001724 D-loop; other site 386585001725 H-loop/switch region; other site 386585001726 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 386585001727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585001728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001729 Walker A/P-loop; other site 386585001730 ATP binding site [chemical binding]; other site 386585001731 Q-loop/lid; other site 386585001732 ABC transporter signature motif; other site 386585001733 Walker B; other site 386585001734 D-loop; other site 386585001735 H-loop/switch region; other site 386585001736 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 386585001737 ammonium transporter; Provisional; Region: PRK10666 386585001738 acyl-CoA thioesterase II; Provisional; Region: PRK10526 386585001739 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 386585001740 active site 386585001741 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 386585001742 catalytic triad [active] 386585001743 dimer interface [polypeptide binding]; other site 386585001744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 386585001745 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 386585001746 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 386585001747 DNA binding site [nucleotide binding] 386585001748 active site 386585001749 Uncharacterized conserved protein [Function unknown]; Region: COG5507 386585001750 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 386585001751 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 386585001752 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585001753 Inner membrane protein YlaC; Region: YlaC; pfam10777 386585001754 maltose O-acetyltransferase; Provisional; Region: PRK10092 386585001755 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 386585001756 active site 386585001757 substrate binding site [chemical binding]; other site 386585001758 trimer interface [polypeptide binding]; other site 386585001759 CoA binding site [chemical binding]; other site 386585001760 gene expression modulator; Provisional; Region: PRK10945 386585001761 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 386585001762 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 386585001763 MMPL family; Region: MMPL; cl14618 386585001764 MMPL family; Region: MMPL; cl14618 386585001765 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 386585001766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 386585001767 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585001768 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 386585001769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585001770 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 386585001771 hypothetical protein; Provisional; Region: PRK11281 386585001772 FSIP1 family; Region: FSIP1; pfam15554 386585001773 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 386585001774 Mechanosensitive ion channel; Region: MS_channel; pfam00924 386585001775 hypothetical protein; Provisional; Region: PRK11038 386585001776 primosomal replication protein N''; Provisional; Region: PRK10093 386585001777 hypothetical protein; Provisional; Region: PRK10527 386585001778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585001779 active site 386585001780 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 386585001781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585001782 Walker A motif; other site 386585001783 ATP binding site [chemical binding]; other site 386585001784 Walker B motif; other site 386585001785 DNA polymerase III subunit delta'; Validated; Region: PRK08485 386585001786 arginine finger; other site 386585001787 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 386585001788 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 386585001789 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 386585001790 hypothetical protein; Validated; Region: PRK00153 386585001791 recombination protein RecR; Reviewed; Region: recR; PRK00076 386585001792 RecR protein; Region: RecR; pfam02132 386585001793 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 386585001794 putative active site [active] 386585001795 putative metal-binding site [ion binding]; other site 386585001796 tetramer interface [polypeptide binding]; other site 386585001797 heat shock protein 90; Provisional; Region: PRK05218 386585001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585001799 ATP binding site [chemical binding]; other site 386585001800 Mg2+ binding site [ion binding]; other site 386585001801 G-X-G motif; other site 386585001802 Hsp90 protein; Region: HSP90; pfam00183 386585001803 adenylate kinase; Reviewed; Region: adk; PRK00279 386585001804 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 386585001805 AMP-binding site [chemical binding]; other site 386585001806 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 386585001807 ferrochelatase; Region: hemH; TIGR00109 386585001808 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 386585001809 C-terminal domain interface [polypeptide binding]; other site 386585001810 active site 386585001811 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 386585001812 active site 386585001813 N-terminal domain interface [polypeptide binding]; other site 386585001814 acetyl esterase; Provisional; Region: PRK10162 386585001815 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 386585001816 inosine/guanosine kinase; Provisional; Region: PRK15074 386585001817 adenosine kinase; Provisional; Region: PTZ00247 386585001818 substrate binding site [chemical binding]; other site 386585001819 ATP binding site [chemical binding]; other site 386585001820 putative cation:proton antiport protein; Provisional; Region: PRK10669 386585001821 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 386585001822 TrkA-N domain; Region: TrkA_N; pfam02254 386585001823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585001824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585001825 putative substrate translocation pore; other site 386585001826 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 386585001827 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 386585001828 active site 386585001829 metal binding site [ion binding]; metal-binding site 386585001830 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 386585001831 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 386585001832 putative deacylase active site [active] 386585001833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 386585001834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585001835 non-specific DNA binding site [nucleotide binding]; other site 386585001836 salt bridge; other site 386585001837 sequence-specific DNA binding site [nucleotide binding]; other site 386585001838 copper exporting ATPase; Provisional; Region: copA; PRK10671 386585001839 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 386585001840 metal-binding site [ion binding] 386585001841 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 386585001842 metal-binding site [ion binding] 386585001843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 386585001844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585001845 motif II; other site 386585001846 glutaminase; Reviewed; Region: PRK12356 386585001847 amino acid transporter; Region: 2A0306; TIGR00909 386585001848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 386585001849 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 386585001850 Outer membrane efflux protein; Region: OEP; pfam02321 386585001851 Outer membrane efflux protein; Region: OEP; pfam02321 386585001852 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001853 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001854 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001855 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001856 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001857 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001858 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 386585001859 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001860 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001861 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001862 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001863 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001864 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001865 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001866 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001867 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001868 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001869 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001870 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001871 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001872 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001873 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001874 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001875 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001876 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001877 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001878 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001879 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001880 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001881 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001882 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001883 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001884 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001885 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001886 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001887 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001888 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001889 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001890 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 386585001891 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 386585001892 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 386585001893 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 386585001894 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 386585001895 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 386585001896 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 386585001897 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 386585001898 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 386585001899 putative active site [active] 386585001900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585001901 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 386585001902 Walker A/P-loop; other site 386585001903 ATP binding site [chemical binding]; other site 386585001904 Q-loop/lid; other site 386585001905 ABC transporter signature motif; other site 386585001906 Walker B; other site 386585001907 D-loop; other site 386585001908 H-loop/switch region; other site 386585001909 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 386585001910 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 386585001911 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585001912 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 386585001913 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 386585001914 DNA binding residues [nucleotide binding] 386585001915 dimer interface [polypeptide binding]; other site 386585001916 copper binding site [ion binding]; other site 386585001917 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 386585001918 Shugoshin N-terminal coiled-coil region; Region: Shugoshin_N; pfam07558 386585001919 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 386585001920 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 386585001921 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 386585001922 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 386585001923 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 386585001924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585001925 Walker A/P-loop; other site 386585001926 ATP binding site [chemical binding]; other site 386585001927 Q-loop/lid; other site 386585001928 ABC transporter signature motif; other site 386585001929 Walker B; other site 386585001930 D-loop; other site 386585001931 H-loop/switch region; other site 386585001932 TIGR00245 family protein; Region: TIGR00245 386585001933 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 386585001934 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 386585001935 Tetratricopeptide repeat; Region: TPR_20; pfam14561 386585001936 short chain dehydrogenase; Validated; Region: PRK06182 386585001937 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 386585001938 NADP binding site [chemical binding]; other site 386585001939 active site 386585001940 steroid binding site; other site 386585001941 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 386585001942 active site 386585001943 catalytic triad [active] 386585001944 oxyanion hole [active] 386585001945 switch loop; other site 386585001946 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 386585001947 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 386585001948 Walker A/P-loop; other site 386585001949 ATP binding site [chemical binding]; other site 386585001950 Q-loop/lid; other site 386585001951 ABC transporter signature motif; other site 386585001952 Walker B; other site 386585001953 D-loop; other site 386585001954 H-loop/switch region; other site 386585001955 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 386585001956 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 386585001957 FtsX-like permease family; Region: FtsX; pfam02687 386585001958 FtsX-like permease family; Region: FtsX; pfam02687 386585001959 PAAR motif; Region: PAAR_motif; cl15808 386585001960 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585001961 RHS Repeat; Region: RHS_repeat; pfam05593 386585001962 RHS Repeat; Region: RHS_repeat; pfam05593 386585001963 RHS Repeat; Region: RHS_repeat; pfam05593 386585001964 RHS Repeat; Region: RHS_repeat; pfam05593 386585001965 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585001966 RHS Repeat; Region: RHS_repeat; pfam05593 386585001967 RHS Repeat; Region: RHS_repeat; pfam05593 386585001968 RHS protein; Region: RHS; pfam03527 386585001969 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585001970 hypothetical protein; Provisional; Region: PRK14710 386585001971 Winged helix-turn helix; Region: HTH_29; pfam13551 386585001972 Helix-turn-helix domain; Region: HTH_28; pfam13518 386585001973 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 386585001974 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 386585001975 active site residue [active] 386585001976 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 386585001977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585001978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585001979 dimerization interface [polypeptide binding]; other site 386585001980 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 386585001981 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 386585001982 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 386585001983 Bacterial transcriptional regulator; Region: IclR; pfam01614 386585001984 glyoxylate carboligase; Provisional; Region: PRK11269 386585001985 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 386585001986 PYR/PP interface [polypeptide binding]; other site 386585001987 dimer interface [polypeptide binding]; other site 386585001988 TPP binding site [chemical binding]; other site 386585001989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 386585001990 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 386585001991 TPP-binding site [chemical binding]; other site 386585001992 hydroxypyruvate isomerase; Provisional; Region: PRK09997 386585001993 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 386585001994 tartronate semialdehyde reductase; Provisional; Region: PRK15059 386585001995 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 386585001996 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 386585001997 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 386585001998 Na binding site [ion binding]; other site 386585001999 substrate binding site [chemical binding]; other site 386585002000 similar to allantoinase; contains frameshift 386585002001 putative uracil/xanthine transporter; Provisional; Region: PRK11412 386585002002 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 386585002003 glycerate kinase II; Provisional; Region: PRK09932 386585002004 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 386585002005 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 386585002006 Cupin domain; Region: Cupin_2; cl17218 386585002007 allantoate amidohydrolase; Region: AllC; TIGR03176 386585002008 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 386585002009 active site 386585002010 metal binding site [ion binding]; metal-binding site 386585002011 dimer interface [polypeptide binding]; other site 386585002012 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 386585002013 membrane protein FdrA; Validated; Region: PRK06091 386585002014 CoA binding domain; Region: CoA_binding; pfam02629 386585002015 CoA-ligase; Region: Ligase_CoA; pfam00549 386585002016 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 386585002017 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 386585002018 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 386585002019 putative substrate binding site [chemical binding]; other site 386585002020 nucleotide binding site [chemical binding]; other site 386585002021 nucleotide binding site [chemical binding]; other site 386585002022 homodimer interface [polypeptide binding]; other site 386585002023 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 386585002024 ATP-grasp domain; Region: ATP-grasp; pfam02222 386585002025 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 386585002026 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 386585002027 putative active site [active] 386585002028 putative metal binding site [ion binding]; other site 386585002029 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 386585002030 substrate binding site [chemical binding]; other site 386585002031 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 386585002032 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 386585002033 active site 386585002034 HIGH motif; other site 386585002035 KMSKS motif; other site 386585002036 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 386585002037 tRNA binding surface [nucleotide binding]; other site 386585002038 anticodon binding site; other site 386585002039 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 386585002040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585002041 RNA binding surface [nucleotide binding]; other site 386585002042 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 386585002043 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 386585002044 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 386585002045 homodimer interface [polypeptide binding]; other site 386585002046 NADP binding site [chemical binding]; other site 386585002047 substrate binding site [chemical binding]; other site 386585002048 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 386585002049 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 386585002050 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585002051 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585002052 outer membrane usher protein FimD; Provisional; Region: PRK15198 386585002053 PapC N-terminal domain; Region: PapC_N; pfam13954 386585002054 Outer membrane usher protein; Region: Usher; pfam00577 386585002055 PapC C-terminal domain; Region: PapC_C; pfam13953 386585002056 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 386585002057 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 386585002058 transcriptional regulator FimZ; Provisional; Region: PRK09935 386585002059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585002060 active site 386585002061 phosphorylation site [posttranslational modification] 386585002062 intermolecular recognition site; other site 386585002063 dimerization interface [polypeptide binding]; other site 386585002064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585002065 DNA binding residues [nucleotide binding] 386585002066 dimerization interface [polypeptide binding]; other site 386585002067 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 386585002068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585002069 hypothetical protein; Provisional; Region: PRK09936 386585002070 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 386585002071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585002072 TPR motif; other site 386585002073 binding surface 386585002074 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 386585002075 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 386585002076 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 386585002077 active site 386585002078 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 386585002079 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 386585002080 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 386585002081 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585002082 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585002083 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585002084 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 386585002085 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585002086 Metallopeptidase toxin 4; Region: Tox-MPTase4; pfam15640 386585002087 PAAR motif; Region: PAAR_motif; pfam05488 386585002088 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 386585002089 RHS Repeat; Region: RHS_repeat; pfam05593 386585002090 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 386585002091 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 386585002092 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585002093 RHS Repeat; Region: RHS_repeat; pfam05593 386585002094 RHS Repeat; Region: RHS_repeat; pfam05593 386585002095 RHS Repeat; Region: RHS_repeat; pfam05593 386585002096 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 386585002097 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 386585002098 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585002099 Uncharacterized conserved protein [Function unknown]; Region: COG5435 386585002100 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 386585002101 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 386585002102 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 386585002103 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 386585002104 sensor kinase CusS; Provisional; Region: PRK09835 386585002105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585002106 dimerization interface [polypeptide binding]; other site 386585002107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585002108 dimer interface [polypeptide binding]; other site 386585002109 phosphorylation site [posttranslational modification] 386585002110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585002111 ATP binding site [chemical binding]; other site 386585002112 Mg2+ binding site [ion binding]; other site 386585002113 G-X-G motif; other site 386585002114 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 386585002115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585002116 active site 386585002117 phosphorylation site [posttranslational modification] 386585002118 intermolecular recognition site; other site 386585002119 dimerization interface [polypeptide binding]; other site 386585002120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585002121 DNA binding site [nucleotide binding] 386585002122 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 386585002123 Outer membrane efflux protein; Region: OEP; pfam02321 386585002124 Outer membrane efflux protein; Region: OEP; pfam02321 386585002125 periplasmic copper-binding protein; Provisional; Region: PRK09838 386585002126 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 386585002127 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585002128 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 386585002129 phenylalanine transporter; Provisional; Region: PRK10249 386585002130 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585002131 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 386585002132 Mechanosensitive ion channel; Region: MS_channel; pfam00924 386585002133 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 386585002134 dimer interface [polypeptide binding]; other site 386585002135 FMN binding site [chemical binding]; other site 386585002136 hypothetical protein; Provisional; Region: PRK10250 386585002137 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 386585002138 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 386585002139 Hok/gef family; Region: HOK_GEF; pfam01848 386585002140 Hok/gef family; Region: HOK_GEF; pfam01848 386585002141 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 386585002142 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 386585002143 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 386585002144 outer membrane receptor FepA; Provisional; Region: PRK13524 386585002145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585002146 N-terminal plug; other site 386585002147 ligand-binding site [chemical binding]; other site 386585002148 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 386585002149 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 386585002150 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 386585002151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 386585002152 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 386585002153 Condensation domain; Region: Condensation; cl19241 386585002154 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 386585002155 acyl-activating enzyme (AAE) consensus motif; other site 386585002156 AMP binding site [chemical binding]; other site 386585002157 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 386585002158 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 386585002159 LPS O-antigen length regulator; Provisional; Region: PRK10381 386585002160 Chain length determinant protein; Region: Wzz; pfam02706 386585002161 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 386585002162 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 386585002163 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 386585002164 Walker A/P-loop; other site 386585002165 ATP binding site [chemical binding]; other site 386585002166 Q-loop/lid; other site 386585002167 ABC transporter signature motif; other site 386585002168 Walker B; other site 386585002169 D-loop; other site 386585002170 H-loop/switch region; other site 386585002171 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585002172 ABC-ATPase subunit interface; other site 386585002173 dimer interface [polypeptide binding]; other site 386585002174 putative PBP binding regions; other site 386585002175 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585002176 ABC-ATPase subunit interface; other site 386585002177 dimer interface [polypeptide binding]; other site 386585002178 putative PBP binding regions; other site 386585002179 enterobactin exporter EntS; Provisional; Region: PRK10489 386585002180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585002181 putative substrate translocation pore; other site 386585002182 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 386585002183 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 386585002184 siderophore binding site; other site 386585002185 isochorismate synthase EntC; Provisional; Region: PRK15016 386585002186 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 386585002187 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 386585002188 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 386585002189 acyl-activating enzyme (AAE) consensus motif; other site 386585002190 active site 386585002191 AMP binding site [chemical binding]; other site 386585002192 substrate binding site [chemical binding]; other site 386585002193 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 386585002194 hydrophobic substrate binding pocket; other site 386585002195 active site 386585002196 conserved cis-peptide bond; other site 386585002197 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 386585002198 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 386585002199 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 386585002200 putative NAD(P) binding site [chemical binding]; other site 386585002201 active site 386585002202 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 386585002203 CoenzymeA binding site [chemical binding]; other site 386585002204 subunit interaction site [polypeptide binding]; other site 386585002205 PHB binding site; other site 386585002206 carbon starvation protein A; Provisional; Region: PRK15015 386585002207 Carbon starvation protein CstA; Region: CstA; pfam02554 386585002208 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 386585002209 Uncharacterized small protein [Function unknown]; Region: COG2879 386585002210 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 386585002211 putative active site [active] 386585002212 metal binding site [ion binding]; metal-binding site 386585002213 methionine aminotransferase; Validated; Region: PRK09082 386585002214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585002215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585002216 homodimer interface [polypeptide binding]; other site 386585002217 catalytic residue [active] 386585002218 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 386585002219 ParB-like nuclease domain; Region: ParBc; pfam02195 386585002220 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 386585002221 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 386585002222 Active Sites [active] 386585002223 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 386585002224 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 386585002225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585002226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585002227 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 386585002228 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 386585002229 dimerization domain [polypeptide binding]; other site 386585002230 dimer interface [polypeptide binding]; other site 386585002231 catalytic residues [active] 386585002232 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 386585002233 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 386585002234 dimer interface [polypeptide binding]; other site 386585002235 decamer (pentamer of dimers) interface [polypeptide binding]; other site 386585002236 catalytic triad [active] 386585002237 peroxidatic and resolving cysteines [active] 386585002238 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 386585002239 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 386585002240 catalytic residue [active] 386585002241 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 386585002242 catalytic residues [active] 386585002243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585002244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585002245 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585002246 Ligand Binding Site [chemical binding]; other site 386585002247 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 386585002248 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585002249 NAD binding site [chemical binding]; other site 386585002250 catalytic Zn binding site [ion binding]; other site 386585002251 structural Zn binding site [ion binding]; other site 386585002252 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 386585002253 Rnk N-terminus; Region: Rnk_N; pfam14760 386585002254 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 386585002255 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 386585002256 B1 nucleotide binding pocket [chemical binding]; other site 386585002257 B2 nucleotide binding pocket [chemical binding]; other site 386585002258 CAS motifs; other site 386585002259 active site 386585002260 anion transporter; Region: dass; TIGR00785 386585002261 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 386585002262 transmembrane helices; other site 386585002263 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 386585002264 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 386585002265 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 386585002266 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 386585002267 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 386585002268 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 386585002269 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 386585002270 putative active site [active] 386585002271 (T/H)XGH motif; other site 386585002272 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 386585002273 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 386585002274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585002275 putative active site [active] 386585002276 heme pocket [chemical binding]; other site 386585002277 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 386585002278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585002279 ATP binding site [chemical binding]; other site 386585002280 Mg2+ binding site [ion binding]; other site 386585002281 G-X-G motif; other site 386585002282 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 386585002283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585002284 active site 386585002285 phosphorylation site [posttranslational modification] 386585002286 intermolecular recognition site; other site 386585002287 dimerization interface [polypeptide binding]; other site 386585002288 Transcriptional regulator; Region: CitT; pfam12431 386585002289 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 386585002290 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 386585002291 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 386585002292 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 386585002293 DNA-binding site [nucleotide binding]; DNA binding site 386585002294 RNA-binding motif; other site 386585002295 chromosome condensation membrane protein; Provisional; Region: PRK14196 386585002296 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 386585002297 putative active site [active] 386585002298 catalytic triad [active] 386585002299 putative dimer interface [polypeptide binding]; other site 386585002300 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 386585002301 lipoyl synthase; Provisional; Region: PRK05481 386585002302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585002303 FeS/SAM binding site; other site 386585002304 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 386585002305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585002306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585002307 dimerization interface [polypeptide binding]; other site 386585002308 lipoate-protein ligase B; Provisional; Region: PRK14342 386585002309 hypothetical protein; Provisional; Region: PRK04998 386585002310 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 386585002311 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 386585002312 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 386585002313 rare lipoprotein A; Provisional; Region: PRK10672 386585002314 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 386585002315 Sporulation related domain; Region: SPOR; pfam05036 386585002316 cell wall shape-determining protein; Provisional; Region: PRK10794 386585002317 penicillin-binding protein 2; Provisional; Region: PRK10795 386585002318 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 386585002319 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 386585002320 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 386585002321 ribosome-associated protein; Provisional; Region: PRK11538 386585002322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 386585002323 catalytic core [active] 386585002324 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 386585002325 active site 386585002326 (T/H)XGH motif; other site 386585002327 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 386585002328 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 386585002329 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 386585002330 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 386585002331 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 386585002332 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 386585002333 active site 386585002334 HIGH motif; other site 386585002335 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 386585002336 KMSKS motif; other site 386585002337 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 386585002338 tRNA binding surface [nucleotide binding]; other site 386585002339 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 386585002340 hypothetical protein; Provisional; Region: PRK11032 386585002341 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 386585002342 Sel1-like repeats; Region: SEL1; smart00671 386585002343 Sel1-like repeats; Region: SEL1; smart00671 386585002344 Sel1-like repeats; Region: SEL1; smart00671 386585002345 Sel1-like repeats; Region: SEL1; smart00671 386585002346 Sel1-like repeats; Region: SEL1; smart00671 386585002347 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 386585002348 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 386585002349 HSP70 interaction site [polypeptide binding]; other site 386585002350 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 386585002351 Sel1-like repeats; Region: SEL1; smart00671 386585002352 Sel1-like repeats; Region: SEL1; smart00671 386585002353 Sel1-like repeats; Region: SEL1; smart00671 386585002354 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 386585002355 similar to YbeV; contains frameshift 386585002356 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 386585002357 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 386585002358 nucleotide binding site [chemical binding]; other site 386585002359 putative NEF/HSP70 interaction site [polypeptide binding]; other site 386585002360 SBD interface [polypeptide binding]; other site 386585002361 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 386585002362 active site 386585002363 tetramer interface [polypeptide binding]; other site 386585002364 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 386585002365 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 386585002366 Walker A/P-loop; other site 386585002367 ATP binding site [chemical binding]; other site 386585002368 Q-loop/lid; other site 386585002369 ABC transporter signature motif; other site 386585002370 Walker B; other site 386585002371 D-loop; other site 386585002372 H-loop/switch region; other site 386585002373 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 386585002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585002375 dimer interface [polypeptide binding]; other site 386585002376 conserved gate region; other site 386585002377 putative PBP binding loops; other site 386585002378 ABC-ATPase subunit interface; other site 386585002379 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 386585002380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585002381 dimer interface [polypeptide binding]; other site 386585002382 conserved gate region; other site 386585002383 putative PBP binding loops; other site 386585002384 ABC-ATPase subunit interface; other site 386585002385 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 386585002386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585002387 substrate binding pocket [chemical binding]; other site 386585002388 membrane-bound complex binding site; other site 386585002389 hinge residues; other site 386585002390 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 386585002391 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 386585002392 putative active site [active] 386585002393 catalytic triad [active] 386585002394 putative dimer interface [polypeptide binding]; other site 386585002395 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 386585002396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 386585002397 Transporter associated domain; Region: CorC_HlyC; smart01091 386585002398 metal-binding heat shock protein; Provisional; Region: PRK00016 386585002399 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 386585002400 PhoH-like protein; Region: PhoH; pfam02562 386585002401 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 386585002402 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 386585002403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585002404 FeS/SAM binding site; other site 386585002405 TRAM domain; Region: TRAM; pfam01938 386585002406 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 386585002407 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 386585002408 asparagine synthetase B; Provisional; Region: asnB; PRK09431 386585002409 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 386585002410 active site 386585002411 dimer interface [polypeptide binding]; other site 386585002412 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 386585002413 Ligand Binding Site [chemical binding]; other site 386585002414 Molecular Tunnel; other site 386585002415 UMP phosphatase; Provisional; Region: PRK10444 386585002416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585002417 active site 386585002418 motif I; other site 386585002419 motif II; other site 386585002420 MarR family; Region: MarR_2; cl17246 386585002421 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 386585002422 ROK family; Region: ROK; pfam00480 386585002423 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 386585002424 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 386585002425 active site 386585002426 dimer interface [polypeptide binding]; other site 386585002427 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 386585002428 active site 386585002429 trimer interface [polypeptide binding]; other site 386585002430 allosteric site; other site 386585002431 active site lid [active] 386585002432 hexamer (dimer of trimers) interface [polypeptide binding]; other site 386585002433 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 386585002434 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 386585002435 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585002436 active site turn [active] 386585002437 phosphorylation site [posttranslational modification] 386585002438 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 386585002439 HPr interaction site; other site 386585002440 glycerol kinase (GK) interaction site [polypeptide binding]; other site 386585002441 active site 386585002442 phosphorylation site [posttranslational modification] 386585002443 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 386585002444 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 386585002445 active site 386585002446 HIGH motif; other site 386585002447 KMSKS motif; other site 386585002448 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 386585002449 similar to Escherichia coli YbfM; disrupted by frameshift 386585002450 YbfN-like lipoprotein; Region: YbfN; pfam13982 386585002451 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 386585002452 metal binding site 2 [ion binding]; metal-binding site 386585002453 putative DNA binding helix; other site 386585002454 metal binding site 1 [ion binding]; metal-binding site 386585002455 dimer interface [polypeptide binding]; other site 386585002456 structural Zn2+ binding site [ion binding]; other site 386585002457 flavodoxin FldA; Validated; Region: PRK09267 386585002458 LexA regulated protein; Provisional; Region: PRK11675 386585002459 acyl-CoA esterase; Provisional; Region: PRK10673 386585002460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 386585002461 replication initiation regulator SeqA; Provisional; Region: PRK11187 386585002462 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 386585002463 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 386585002464 active site 386585002465 substrate binding site [chemical binding]; other site 386585002466 metal binding site [ion binding]; metal-binding site 386585002467 putrescine transporter; Provisional; Region: potE; PRK10655 386585002468 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 386585002469 ornithine decarboxylase; Provisional; Region: PRK13578 386585002470 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 386585002471 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 386585002472 homodimer interface [polypeptide binding]; other site 386585002473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585002474 catalytic residue [active] 386585002475 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 386585002476 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 386585002477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585002478 active site 386585002479 phosphorylation site [posttranslational modification] 386585002480 intermolecular recognition site; other site 386585002481 dimerization interface [polypeptide binding]; other site 386585002482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585002483 DNA binding site [nucleotide binding] 386585002484 sensor protein KdpD; Provisional; Region: PRK10490 386585002485 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 386585002486 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 386585002487 Ligand Binding Site [chemical binding]; other site 386585002488 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 386585002489 GAF domain; Region: GAF_3; pfam13492 386585002490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585002491 dimer interface [polypeptide binding]; other site 386585002492 phosphorylation site [posttranslational modification] 386585002493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585002494 ATP binding site [chemical binding]; other site 386585002495 Mg2+ binding site [ion binding]; other site 386585002496 G-X-G motif; other site 386585002497 K+-transporting ATPase, c chain; Region: KdpC; pfam02669 386585002498 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 386585002499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 386585002500 Soluble P-type ATPase [General function prediction only]; Region: COG4087 386585002501 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 386585002502 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 386585002503 PAAR motif; Region: PAAR_motif; cl15808 386585002504 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585002505 RHS Repeat; Region: RHS_repeat; pfam05593 386585002506 RHS Repeat; Region: RHS_repeat; pfam05593 386585002507 RHS Repeat; Region: RHS_repeat; pfam05593 386585002508 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585002509 RHS Repeat; Region: RHS_repeat; pfam05593 386585002510 RHS Repeat; Region: RHS_repeat; pfam05593 386585002511 RHS protein; Region: RHS; pfam03527 386585002512 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585002513 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 386585002514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 386585002515 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585002516 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585002517 hypothetical protein; Provisional; Region: PRK10167 386585002518 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 386585002519 DNA photolyase; Region: DNA_photolyase; pfam00875 386585002520 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 386585002521 dipeptide/tripeptide permease D; Provisional; Region: PRK15462 386585002522 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 386585002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585002524 putative substrate translocation pore; other site 386585002525 metal-binding protein; Provisional; Region: PRK10799 386585002526 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 386585002527 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 386585002528 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 386585002529 putative active site [active] 386585002530 endonuclease VIII; Provisional; Region: PRK10445 386585002531 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 386585002532 DNA binding site [nucleotide binding] 386585002533 catalytic residue [active] 386585002534 putative catalytic residues [active] 386585002535 H2TH interface [polypeptide binding]; other site 386585002536 intercalation triad [nucleotide binding]; other site 386585002537 substrate specificity determining residue; other site 386585002538 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 386585002539 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 386585002540 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 386585002541 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 386585002542 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 386585002543 Fimbrial protein; Region: Fimbrial; pfam00419 386585002544 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 386585002545 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585002546 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585002547 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 386585002548 PapC N-terminal domain; Region: PapC_N; pfam13954 386585002549 Outer membrane usher protein; Region: Usher; pfam00577 386585002550 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585002551 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 386585002552 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 386585002553 dimer interface [polypeptide binding]; other site 386585002554 active site 386585002555 citrylCoA binding site [chemical binding]; other site 386585002556 NADH binding [chemical binding]; other site 386585002557 cationic pore residues; other site 386585002558 oxalacetate/citrate binding site [chemical binding]; other site 386585002559 coenzyme A binding site [chemical binding]; other site 386585002560 catalytic triad [active] 386585002561 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 386585002562 Iron-sulfur protein interface; other site 386585002563 proximal quinone binding site [chemical binding]; other site 386585002564 SdhD (CybS) interface [polypeptide binding]; other site 386585002565 proximal heme binding site [chemical binding]; other site 386585002566 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 386585002567 SdhC subunit interface [polypeptide binding]; other site 386585002568 proximal heme binding site [chemical binding]; other site 386585002569 cardiolipin binding site; other site 386585002570 Iron-sulfur protein interface; other site 386585002571 proximal quinone binding site [chemical binding]; other site 386585002572 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 386585002573 L-aspartate oxidase; Provisional; Region: PRK06175 386585002574 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 386585002575 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 386585002576 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 386585002577 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 386585002578 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 386585002579 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 386585002580 TPP-binding site [chemical binding]; other site 386585002581 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 386585002582 dimer interface [polypeptide binding]; other site 386585002583 PYR/PP interface [polypeptide binding]; other site 386585002584 TPP binding site [chemical binding]; other site 386585002585 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 386585002586 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 386585002587 E3 interaction surface; other site 386585002588 lipoyl attachment site [posttranslational modification]; other site 386585002589 e3 binding domain; Region: E3_binding; pfam02817 386585002590 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 386585002591 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 386585002592 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 386585002593 CoA-ligase; Region: Ligase_CoA; pfam00549 386585002594 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 386585002595 CoA binding domain; Region: CoA_binding; pfam02629 386585002596 CoA-ligase; Region: Ligase_CoA; pfam00549 386585002597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585002598 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 386585002599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585002600 dimerization interface [polypeptide binding]; other site 386585002601 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 386585002602 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 386585002603 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 386585002604 homodimer interface [polypeptide binding]; other site 386585002605 Walker A motif; other site 386585002606 ATP binding site [chemical binding]; other site 386585002607 hydroxycobalamin binding site [chemical binding]; other site 386585002608 Walker B motif; other site 386585002609 putative fumarate hydratase; Provisional; Region: PRK15392 386585002610 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 386585002611 Fumarase C-terminus; Region: Fumerase_C; pfam05683 386585002612 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 386585002613 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 386585002614 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 386585002615 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 386585002616 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 386585002617 dimer interface [polypeptide binding]; other site 386585002618 active site 386585002619 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 386585002620 substrate binding site [chemical binding]; other site 386585002621 B12 cofactor binding site [chemical binding]; other site 386585002622 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 386585002623 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 386585002624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 386585002625 conserved hypothetical protein; Region: glmL_fam; TIGR01319 386585002626 nucleotide binding site [chemical binding]; other site 386585002627 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 386585002628 B12 binding site [chemical binding]; other site 386585002629 heterodimer interface [polypeptide binding]; other site 386585002630 cobalt ligand [ion binding]; other site 386585002631 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 386585002632 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 386585002633 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 386585002634 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 386585002635 hypothetical protein; Provisional; Region: PRK10588 386585002636 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 386585002637 active site 386585002638 colicin uptake protein TolQ; Provisional; Region: PRK10801 386585002639 colicin uptake protein TolR; Provisional; Region: PRK11024 386585002640 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 386585002641 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 386585002642 TolA C-terminal; Region: TolA; pfam06519 386585002643 translocation protein TolB; Provisional; Region: tolB; PRK03629 386585002644 TolB amino-terminal domain; Region: TolB_N; pfam04052 386585002645 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 386585002646 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 386585002647 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 386585002648 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 386585002649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585002650 ligand binding site [chemical binding]; other site 386585002651 tol-pal system protein YbgF; Provisional; Region: PRK10803 386585002652 Tetratricopeptide repeat; Region: TPR_6; pfam13174 386585002653 Tetratricopeptide repeat; Region: TPR_6; pfam13174 386585002654 quinolinate synthetase; Provisional; Region: PRK09375 386585002655 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 386585002656 zinc transporter ZitB; Provisional; Region: PRK03557 386585002657 YbgS-like protein; Region: YbgS; pfam13985 386585002658 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 386585002659 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 386585002660 catalytic core [active] 386585002661 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 386585002662 active site 386585002663 catalytic residues [active] 386585002664 galactokinase; Provisional; Region: PRK05101 386585002665 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 386585002666 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 386585002667 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 386585002668 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 386585002669 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 386585002670 dimer interface [polypeptide binding]; other site 386585002671 active site 386585002672 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 386585002673 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 386585002674 NAD binding site [chemical binding]; other site 386585002675 homodimer interface [polypeptide binding]; other site 386585002676 active site 386585002677 substrate binding site [chemical binding]; other site 386585002678 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 386585002679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 386585002680 Walker A/P-loop; other site 386585002681 ATP binding site [chemical binding]; other site 386585002682 Q-loop/lid; other site 386585002683 ABC transporter signature motif; other site 386585002684 Walker B; other site 386585002685 D-loop; other site 386585002686 H-loop/switch region; other site 386585002687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585002688 Walker A/P-loop; other site 386585002689 ATP binding site [chemical binding]; other site 386585002690 Q-loop/lid; other site 386585002691 ABC transporter signature motif; other site 386585002692 Walker B; other site 386585002693 D-loop; other site 386585002694 H-loop/switch region; other site 386585002695 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 386585002696 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 386585002697 molybdenum-pterin binding domain; Region: Mop; TIGR00638 386585002698 TOBE domain; Region: TOBE; pfam03459 386585002699 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 386585002700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585002701 substrate binding pocket [chemical binding]; other site 386585002702 membrane-bound complex binding site; other site 386585002703 hinge residues; other site 386585002704 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 386585002705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585002706 dimer interface [polypeptide binding]; other site 386585002707 conserved gate region; other site 386585002708 putative PBP binding loops; other site 386585002709 ABC-ATPase subunit interface; other site 386585002710 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 386585002711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585002712 Walker A/P-loop; other site 386585002713 ATP binding site [chemical binding]; other site 386585002714 Q-loop/lid; other site 386585002715 ABC transporter signature motif; other site 386585002716 Walker B; other site 386585002717 D-loop; other site 386585002718 H-loop/switch region; other site 386585002719 molybdenum-pterin binding domain; Region: Mop; TIGR00638 386585002720 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 386585002721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585002722 active site 386585002723 motif I; other site 386585002724 motif II; other site 386585002725 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585002726 6-phosphogluconolactonase; Provisional; Region: PRK11028 386585002727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585002728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585002729 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 386585002730 putative dimerization interface [polypeptide binding]; other site 386585002731 PrpF protein; Region: PrpF; pfam04303 386585002732 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 386585002733 anion transporter; Region: dass; TIGR00785 386585002734 transmembrane helices; other site 386585002735 putative hydratase; Provisional; Region: PRK11413 386585002736 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 386585002737 substrate binding site [chemical binding]; other site 386585002738 ligand binding site [chemical binding]; other site 386585002739 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 386585002740 substrate binding site [chemical binding]; other site 386585002741 acyl-CoA thioesterase; Provisional; Region: PRK10531 386585002742 Pectinesterase; Region: Pectinesterase; cl01911 386585002743 similar to integrase [Bacteriophage 434] gi|138559|sp|P27078|VINT_BP434 386585002744 Excisionase-like protein; Region: Exc; pfam07825 386585002745 DksA-like zinc finger domain containing protein; Region: PHA00080 386585002746 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 386585002747 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 386585002748 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 386585002749 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 386585002750 similar to part of Bet [Bacteriophage lambda] gi|137511|sp|P03698|VBET_LAMBD 386585002751 RecT family; Region: RecT; cl04285 386585002752 NINE Protein; Region: NinE; pfam05322 386585002753 NinF protein; Region: NinF; pfam05810 386585002754 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 386585002755 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 386585002756 putative protein phosphatase; Region: PHA02239 386585002757 active site 386585002758 metal binding site [ion binding]; metal-binding site 386585002759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 386585002760 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 386585002761 Lysis protein S; Region: Lysis_S; pfam04971 386585002762 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585002763 catalytic residues [active] 386585002764 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585002765 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 386585002766 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 386585002767 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 386585002768 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 386585002769 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 386585002770 oligomer interface [polypeptide binding]; other site 386585002771 active site residues [active] 386585002772 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 386585002773 Uncharacterized conserved protein [Function unknown]; Region: COG5471 386585002774 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 386585002775 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 386585002776 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 386585002777 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 386585002778 Phage tail protein; Region: Phage_tail_3; pfam08813 386585002779 Bacterial Ig-like domain 2; Region: BID_2; smart00635 386585002780 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 386585002781 Minor tail protein T; Region: Phage_tail_T; pfam06223 386585002782 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585002783 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 386585002784 BAF1 / ABF1 chromatin reorganizing factor; Region: BAF1_ABF1; pfam04684 386585002785 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585002786 Phage-related protein [Function unknown]; Region: COG4718 386585002787 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585002788 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 386585002789 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585002790 NlpC/P60 family; Region: NLPC_P60; cl17555 386585002791 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585002792 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585002793 Putative phage tail protein; Region: Phage-tail_3; pfam13550 386585002794 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 386585002795 Interdomain contacts; other site 386585002796 Cytokine receptor motif; other site 386585002797 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585002798 Fibronectin type III protein; Region: DUF3672; pfam12421 386585002799 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 386585002800 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585002801 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585002802 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585002803 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585002804 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 386585002805 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 386585002806 similar to part of tail fiber assembly proteins e.g. ORF194 [Bacteriophage lambda] gi|1742246|dbj|BAA14978.1 386585002807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 386585002808 Effector protein; Region: Peptidase_M91; pfam14891 386585002809 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 386585002810 substrate binding site [chemical binding]; other site 386585002811 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 386585002812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585002813 inhibitor-cofactor binding pocket; inhibition site 386585002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585002815 catalytic residue [active] 386585002816 biotin synthase; Provisional; Region: PRK15108 386585002817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585002818 FeS/SAM binding site; other site 386585002819 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 386585002820 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 386585002821 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 386585002822 substrate-cofactor binding pocket; other site 386585002823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585002824 catalytic residue [active] 386585002825 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 386585002826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585002827 S-adenosylmethionine binding site [chemical binding]; other site 386585002828 AAA domain; Region: AAA_26; pfam13500 386585002829 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 386585002830 active site 386585002831 ADP binding site [chemical binding]; other site 386585002832 excinuclease ABC subunit B; Provisional; Region: PRK05298 386585002833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585002834 ATP binding site [chemical binding]; other site 386585002835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585002836 nucleotide binding region [chemical binding]; other site 386585002837 ATP-binding site [chemical binding]; other site 386585002838 Ultra-violet resistance protein B; Region: UvrB; pfam12344 386585002839 UvrB/uvrC motif; Region: UVR; pfam02151 386585002840 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 386585002841 phosphate binding site [ion binding]; other site 386585002842 putative substrate binding pocket [chemical binding]; other site 386585002843 dimer interface [polypeptide binding]; other site 386585002844 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 386585002845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585002846 FeS/SAM binding site; other site 386585002847 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 386585002848 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 386585002849 MPT binding site; other site 386585002850 trimer interface [polypeptide binding]; other site 386585002851 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 386585002852 trimer interface [polypeptide binding]; other site 386585002853 dimer interface [polypeptide binding]; other site 386585002854 putative active site [active] 386585002855 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 386585002856 MoaE interaction surface [polypeptide binding]; other site 386585002857 MoeB interaction surface [polypeptide binding]; other site 386585002858 thiocarboxylated glycine; other site 386585002859 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 386585002860 MoaE homodimer interface [polypeptide binding]; other site 386585002861 MoaD interaction [polypeptide binding]; other site 386585002862 active site residues [active] 386585002863 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 386585002864 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 386585002865 Predicted integral membrane protein [Function unknown]; Region: COG0392 386585002866 cardiolipin synthase 2; Provisional; Region: PRK11263 386585002867 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 386585002868 putative active site [active] 386585002869 catalytic site [active] 386585002870 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 386585002871 putative active site [active] 386585002872 catalytic site [active] 386585002873 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 386585002874 putative catalytic site [active] 386585002875 putative metal binding site [ion binding]; other site 386585002876 putative phosphate binding site [ion binding]; other site 386585002877 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 386585002878 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 386585002879 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 386585002880 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 386585002881 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 386585002882 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 386585002883 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 386585002884 Walker A/P-loop; other site 386585002885 ATP binding site [chemical binding]; other site 386585002886 Q-loop/lid; other site 386585002887 ABC transporter signature motif; other site 386585002888 Walker B; other site 386585002889 D-loop; other site 386585002890 H-loop/switch region; other site 386585002891 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 386585002892 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 386585002893 Walker A/P-loop; other site 386585002894 ATP binding site [chemical binding]; other site 386585002895 Q-loop/lid; other site 386585002896 ABC transporter signature motif; other site 386585002897 Walker B; other site 386585002898 D-loop; other site 386585002899 H-loop/switch region; other site 386585002900 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 386585002901 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585002902 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585002903 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 386585002904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585002905 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 386585002906 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 386585002907 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 386585002908 ATP binding site [chemical binding]; other site 386585002909 Mg++ binding site [ion binding]; other site 386585002910 motif III; other site 386585002911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585002912 nucleotide binding region [chemical binding]; other site 386585002913 ATP-binding site [chemical binding]; other site 386585002914 SopA-like central domain; Region: SopA; pfam13981 386585002915 SopA-like catalytic domain; Region: SopA_C; pfam13979 386585002916 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 386585002917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 386585002918 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 386585002919 glycosyl transferase family protein; Provisional; Region: PRK08136 386585002920 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 386585002921 putative dehydrogenase; Provisional; Region: PRK10098 386585002922 hypothetical protein; Provisional; Region: PRK10259 386585002923 hypothetical protein; Provisional; Region: PRK11019 386585002924 Uncharacterized iron-regulated protein [Function unknown]; Region: PiuC; COG3128 386585002925 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 386585002926 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585002927 N-terminal plug; other site 386585002928 ligand-binding site [chemical binding]; other site 386585002929 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 386585002930 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 386585002931 putative mechanosensitive channel protein; Provisional; Region: PRK11465 386585002932 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 386585002933 Mechanosensitive ion channel; Region: MS_channel; pfam00924 386585002934 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 386585002935 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 386585002936 Walker A/P-loop; other site 386585002937 ATP binding site [chemical binding]; other site 386585002938 Q-loop/lid; other site 386585002939 ABC transporter signature motif; other site 386585002940 Walker B; other site 386585002941 D-loop; other site 386585002942 H-loop/switch region; other site 386585002943 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 386585002944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585002945 dimer interface [polypeptide binding]; other site 386585002946 conserved gate region; other site 386585002947 putative PBP binding loops; other site 386585002948 ABC-ATPase subunit interface; other site 386585002949 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 386585002950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585002951 substrate binding pocket [chemical binding]; other site 386585002952 membrane-bound complex binding site; other site 386585002953 hinge residues; other site 386585002954 Ferritin-like domain; Region: Ferritin; pfam00210 386585002955 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 386585002956 dimerization interface [polypeptide binding]; other site 386585002957 DPS ferroxidase diiron center [ion binding]; other site 386585002958 ion pore; other site 386585002959 threonine and homoserine efflux system; Provisional; Region: PRK10532 386585002960 EamA-like transporter family; Region: EamA; pfam00892 386585002961 outer membrane protein X; Provisional; Region: ompX; PRK09408 386585002962 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 386585002963 Sulfatase; Region: Sulfatase; pfam00884 386585002964 manganese transport regulator MntR; Provisional; Region: PRK11050 386585002965 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 386585002966 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 386585002967 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 386585002968 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 386585002969 transmembrane helices; other site 386585002970 L,D-transpeptidase; Provisional; Region: PRK10260 386585002971 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 386585002972 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 386585002973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585002974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585002975 Walker A/P-loop; other site 386585002976 ATP binding site [chemical binding]; other site 386585002977 ABC transporter signature motif; other site 386585002978 Walker B; other site 386585002979 ABC transporter; Region: ABC_tran_2; pfam12848 386585002980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585002981 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 386585002982 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 386585002983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585002984 active site 386585002985 motif I; other site 386585002986 motif II; other site 386585002987 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585002988 similar to YbiW; disrupted due to frameshift 386585002989 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 386585002990 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 386585002991 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 386585002992 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 386585002993 active site 386585002994 intersubunit interactions; other site 386585002995 catalytic residue [active] 386585002996 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 386585002997 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 386585002998 ATP binding site [chemical binding]; other site 386585002999 substrate interface [chemical binding]; other site 386585003000 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 386585003001 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 386585003002 dimer interface [polypeptide binding]; other site 386585003003 putative functional site; other site 386585003004 putative MPT binding site; other site 386585003005 similar to YbiK; disrupted due to frameshift 386585003006 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 386585003007 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585003008 Walker A/P-loop; other site 386585003009 ATP binding site [chemical binding]; other site 386585003010 Q-loop/lid; other site 386585003011 ABC transporter signature motif; other site 386585003012 Walker B; other site 386585003013 D-loop; other site 386585003014 H-loop/switch region; other site 386585003015 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585003016 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585003017 Walker A/P-loop; other site 386585003018 ATP binding site [chemical binding]; other site 386585003019 Q-loop/lid; other site 386585003020 ABC transporter signature motif; other site 386585003021 Walker B; other site 386585003022 D-loop; other site 386585003023 H-loop/switch region; other site 386585003024 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 386585003025 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 386585003026 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 386585003027 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 386585003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003029 dimer interface [polypeptide binding]; other site 386585003030 conserved gate region; other site 386585003031 putative PBP binding loops; other site 386585003032 ABC-ATPase subunit interface; other site 386585003033 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 386585003034 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 386585003035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003036 dimer interface [polypeptide binding]; other site 386585003037 conserved gate region; other site 386585003038 putative PBP binding loops; other site 386585003039 ABC-ATPase subunit interface; other site 386585003040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585003041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585003042 metal binding site [ion binding]; metal-binding site 386585003043 active site 386585003044 I-site; other site 386585003045 Predicted transcriptional regulator [Transcription]; Region: COG2944 386585003046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585003047 non-specific DNA binding site [nucleotide binding]; other site 386585003048 salt bridge; other site 386585003049 sequence-specific DNA binding site [nucleotide binding]; other site 386585003050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 386585003051 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 386585003052 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 386585003053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585003054 FeS/SAM binding site; other site 386585003055 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 386585003056 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 386585003057 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 386585003058 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 386585003059 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 386585003060 putative C-terminal domain interface [polypeptide binding]; other site 386585003061 putative GSH binding site (G-site) [chemical binding]; other site 386585003062 putative dimer interface [polypeptide binding]; other site 386585003063 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 386585003064 N-terminal domain interface [polypeptide binding]; other site 386585003065 dimer interface [polypeptide binding]; other site 386585003066 substrate binding pocket (H-site) [chemical binding]; other site 386585003067 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 386585003068 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 386585003069 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 386585003070 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 386585003071 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 386585003072 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585003073 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 386585003074 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 386585003075 active site 386585003076 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 386585003077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585003078 putative substrate translocation pore; other site 386585003079 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 386585003080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585003081 active site 386585003082 motif I; other site 386585003083 motif II; other site 386585003084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585003085 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 386585003086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585003087 putative substrate translocation pore; other site 386585003088 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 386585003089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585003090 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 386585003091 putative transporter; Provisional; Region: PRK04972 386585003092 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 386585003093 TrkA-C domain; Region: TrkA_C; pfam02080 386585003094 TrkA-C domain; Region: TrkA_C; pfam02080 386585003095 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 386585003096 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 386585003097 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 386585003098 GSH binding site [chemical binding]; other site 386585003099 catalytic residues [active] 386585003100 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 386585003101 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 386585003102 dimer interface [polypeptide binding]; other site 386585003103 FMN binding site [chemical binding]; other site 386585003104 NADPH bind site [chemical binding]; other site 386585003105 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 386585003106 RimK-like ATP-grasp domain; Region: RimK; pfam08443 386585003107 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 386585003108 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 386585003109 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 386585003110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585003111 Walker A/P-loop; other site 386585003112 ATP binding site [chemical binding]; other site 386585003113 Q-loop/lid; other site 386585003114 ABC transporter signature motif; other site 386585003115 Walker B; other site 386585003116 D-loop; other site 386585003117 H-loop/switch region; other site 386585003118 TOBE domain; Region: TOBE_2; pfam08402 386585003119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003120 dimer interface [polypeptide binding]; other site 386585003121 conserved gate region; other site 386585003122 putative PBP binding loops; other site 386585003123 ABC-ATPase subunit interface; other site 386585003124 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 386585003125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003126 dimer interface [polypeptide binding]; other site 386585003127 conserved gate region; other site 386585003128 putative PBP binding loops; other site 386585003129 ABC-ATPase subunit interface; other site 386585003130 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 386585003131 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 386585003132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585003133 S-adenosylmethionine binding site [chemical binding]; other site 386585003134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 386585003135 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 386585003136 active site 386585003137 P-loop; other site 386585003138 phosphorylation site [posttranslational modification] 386585003139 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 386585003140 Sulfatase; Region: Sulfatase; cl19157 386585003141 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 386585003142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585003143 substrate binding pocket [chemical binding]; other site 386585003144 membrane-bound complex binding site; other site 386585003145 hinge residues; other site 386585003146 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 386585003147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003148 dimer interface [polypeptide binding]; other site 386585003149 conserved gate region; other site 386585003150 putative PBP binding loops; other site 386585003151 ABC-ATPase subunit interface; other site 386585003152 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 386585003153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003154 dimer interface [polypeptide binding]; other site 386585003155 conserved gate region; other site 386585003156 putative PBP binding loops; other site 386585003157 ABC-ATPase subunit interface; other site 386585003158 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 386585003159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585003160 substrate binding pocket [chemical binding]; other site 386585003161 membrane-bound complex binding site; other site 386585003162 hinge residues; other site 386585003163 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 386585003164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585003165 Walker A/P-loop; other site 386585003166 ATP binding site [chemical binding]; other site 386585003167 Q-loop/lid; other site 386585003168 ABC transporter signature motif; other site 386585003169 Walker B; other site 386585003170 D-loop; other site 386585003171 H-loop/switch region; other site 386585003172 putative lipoprotein; Provisional; Region: PRK10533 386585003173 hypothetical protein; Provisional; Region: PRK02877 386585003174 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 386585003175 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 386585003176 amidase catalytic site [active] 386585003177 Zn binding residues [ion binding]; other site 386585003178 substrate binding site [chemical binding]; other site 386585003179 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 386585003180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585003181 NAD(P) binding site [chemical binding]; other site 386585003182 active site 386585003183 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 386585003184 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 386585003185 putative NAD(P) binding site [chemical binding]; other site 386585003186 putative active site [active] 386585003187 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 386585003188 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 386585003189 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 386585003190 tetramer interface [polypeptide binding]; other site 386585003191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585003192 catalytic residue [active] 386585003193 pyruvate dehydrogenase; Provisional; Region: PRK09124 386585003194 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 386585003195 PYR/PP interface [polypeptide binding]; other site 386585003196 dimer interface [polypeptide binding]; other site 386585003197 tetramer interface [polypeptide binding]; other site 386585003198 TPP binding site [chemical binding]; other site 386585003199 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 386585003200 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 386585003201 TPP-binding site [chemical binding]; other site 386585003202 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 386585003203 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 386585003204 FAD binding pocket [chemical binding]; other site 386585003205 FAD binding motif [chemical binding]; other site 386585003206 phosphate binding motif [ion binding]; other site 386585003207 beta-alpha-beta structure motif; other site 386585003208 NAD binding pocket [chemical binding]; other site 386585003209 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585003210 catalytic loop [active] 386585003211 iron binding site [ion binding]; other site 386585003212 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 386585003213 cubane metal cluster [ion binding]; other site 386585003214 hybrid metal cluster; other site 386585003215 Predicted membrane protein [Function unknown]; Region: COG2431 386585003216 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 386585003217 amphipathic channel; other site 386585003218 Asn-Pro-Ala signature motifs; other site 386585003219 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 386585003220 AAA domain; Region: AAA_21; pfam13304 386585003221 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 386585003222 putative active site [active] 386585003223 putative metal-binding site [ion binding]; other site 386585003224 Protein of unknown function (DUF535); Region: DUF535; pfam04393 386585003225 macrolide transporter subunit MacA; Provisional; Region: PRK11578 386585003226 HemX; Region: HemX; cl19375 386585003227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585003228 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585003229 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 386585003230 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 386585003231 Walker A/P-loop; other site 386585003232 ATP binding site [chemical binding]; other site 386585003233 Q-loop/lid; other site 386585003234 ABC transporter signature motif; other site 386585003235 Walker B; other site 386585003236 D-loop; other site 386585003237 H-loop/switch region; other site 386585003238 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 386585003239 FtsX-like permease family; Region: FtsX; pfam02687 386585003240 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 386585003241 DNA-binding site [nucleotide binding]; DNA binding site 386585003242 RNA-binding motif; other site 386585003243 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 386585003244 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 386585003245 Clp amino terminal domain; Region: Clp_N; pfam02861 386585003246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585003247 Walker A motif; other site 386585003248 ATP binding site [chemical binding]; other site 386585003249 Walker B motif; other site 386585003250 arginine finger; other site 386585003251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585003252 Walker A motif; other site 386585003253 ATP binding site [chemical binding]; other site 386585003254 Walker B motif; other site 386585003255 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 386585003256 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 386585003257 rRNA binding site [nucleotide binding]; other site 386585003258 predicted 30S ribosome binding site; other site 386585003259 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 386585003260 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 386585003261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585003262 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 386585003263 Walker A/P-loop; other site 386585003264 ATP binding site [chemical binding]; other site 386585003265 Q-loop/lid; other site 386585003266 ABC transporter signature motif; other site 386585003267 Walker B; other site 386585003268 D-loop; other site 386585003269 H-loop/switch region; other site 386585003270 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 386585003271 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585003272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585003273 Walker A/P-loop; other site 386585003274 ATP binding site [chemical binding]; other site 386585003275 Q-loop/lid; other site 386585003276 ABC transporter signature motif; other site 386585003277 Walker B; other site 386585003278 D-loop; other site 386585003279 H-loop/switch region; other site 386585003280 thioredoxin reductase; Provisional; Region: PRK10262 386585003281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585003282 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585003283 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 386585003284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585003285 putative DNA binding site [nucleotide binding]; other site 386585003286 putative Zn2+ binding site [ion binding]; other site 386585003287 AsnC family; Region: AsnC_trans_reg; pfam01037 386585003288 DNA translocase FtsK; Provisional; Region: PRK10263 386585003289 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 386585003290 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 386585003291 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 386585003292 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 386585003293 periplasmic chaperone LolA; Region: lolA; TIGR00547 386585003294 recombination factor protein RarA; Reviewed; Region: PRK13342 386585003295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585003296 Walker A motif; other site 386585003297 ATP binding site [chemical binding]; other site 386585003298 Walker B motif; other site 386585003299 arginine finger; other site 386585003300 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 386585003301 seryl-tRNA synthetase; Provisional; Region: PRK05431 386585003302 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 386585003303 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 386585003304 dimer interface [polypeptide binding]; other site 386585003305 active site 386585003306 motif 1; other site 386585003307 motif 2; other site 386585003308 motif 3; other site 386585003309 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 386585003310 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 386585003311 putative [Fe4-S4] binding site [ion binding]; other site 386585003312 putative molybdopterin cofactor binding site [chemical binding]; other site 386585003313 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 386585003314 putative molybdopterin cofactor binding site; other site 386585003315 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 386585003316 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585003317 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 386585003318 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 386585003319 catalytic triad [active] 386585003320 dimer interface [polypeptide binding]; other site 386585003321 conserved cis-peptide bond; other site 386585003322 putative MFS family transporter protein; Provisional; Region: PRK03633 386585003323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585003324 putative substrate translocation pore; other site 386585003325 Amino acid permease; Region: AA_permease_2; pfam13520 386585003326 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 386585003327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585003328 FeS/SAM binding site; other site 386585003329 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 386585003330 Pyruvate formate lyase 1; Region: PFL1; cd01678 386585003331 coenzyme A binding site [chemical binding]; other site 386585003332 active site 386585003333 catalytic residues [active] 386585003334 glycine loop; other site 386585003335 formate transporter; Provisional; Region: PRK10805 386585003336 uncharacterized domain; Region: TIGR00702 386585003337 Predicted membrane protein [Function unknown]; Region: COG2323 386585003338 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 386585003339 homodimer interface [polypeptide binding]; other site 386585003340 substrate-cofactor binding pocket; other site 386585003341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585003342 catalytic residue [active] 386585003343 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 386585003344 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 386585003345 hinge; other site 386585003346 active site 386585003347 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 386585003348 cytidylate kinase; Provisional; Region: cmk; PRK00023 386585003349 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 386585003350 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 386585003351 active site 386585003352 CMP-binding site; other site 386585003353 The sites determining sugar specificity; other site 386585003354 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 386585003355 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 386585003356 RNA binding site [nucleotide binding]; other site 386585003357 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 386585003358 RNA binding site [nucleotide binding]; other site 386585003359 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 386585003360 RNA binding site [nucleotide binding]; other site 386585003361 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 386585003362 RNA binding site [nucleotide binding]; other site 386585003363 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 386585003364 RNA binding site [nucleotide binding]; other site 386585003365 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 386585003366 RNA binding site [nucleotide binding]; other site 386585003367 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 386585003368 dimer interface [polypeptide binding]; other site 386585003369 DNA binding site [nucleotide binding] 386585003370 ComEC family competence protein; Provisional; Region: PRK11539 386585003371 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 386585003372 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 386585003373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 386585003374 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 386585003375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 386585003376 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 386585003377 Walker A/P-loop; other site 386585003378 ATP binding site [chemical binding]; other site 386585003379 Q-loop/lid; other site 386585003380 ABC transporter signature motif; other site 386585003381 Walker B; other site 386585003382 D-loop; other site 386585003383 H-loop/switch region; other site 386585003384 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 386585003385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 386585003386 hypothetical protein; Provisional; Region: PRK11827 386585003387 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 386585003388 Ligand binding site; other site 386585003389 oligomer interface; other site 386585003390 hypothetical protein; Provisional; Region: PRK10593 386585003391 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 386585003392 putative active site [active] 386585003393 Methyltransferase domain; Region: Methyltransf_31; pfam13847 386585003394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585003395 S-adenosylmethionine binding site [chemical binding]; other site 386585003396 condesin subunit F; Provisional; Region: PRK05260 386585003397 condesin subunit E; Provisional; Region: PRK05256 386585003398 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 386585003399 MukB N-terminal; Region: MukB; pfam04310 386585003400 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 386585003401 murein L,D-transpeptidase; Provisional; Region: PRK10594 386585003402 K+ potassium transporter; Region: K_trans; cl15781 386585003403 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 386585003404 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 386585003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 386585003406 Peptidase M15; Region: Peptidase_M15_3; cl01194 386585003407 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 386585003408 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 386585003409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585003410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585003411 homodimer interface [polypeptide binding]; other site 386585003412 catalytic residue [active] 386585003413 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 386585003414 trimer interface [polypeptide binding]; other site 386585003415 eyelet of channel; other site 386585003416 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 386585003417 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 386585003418 putative dimer interface [polypeptide binding]; other site 386585003419 putative anticodon binding site; other site 386585003420 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 386585003421 homodimer interface [polypeptide binding]; other site 386585003422 motif 1; other site 386585003423 motif 2; other site 386585003424 active site 386585003425 motif 3; other site 386585003426 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 386585003427 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 386585003428 active site 386585003429 aminopeptidase N; Provisional; Region: pepN; PRK14015 386585003430 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 386585003431 active site 386585003432 Zn binding site [ion binding]; other site 386585003433 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 386585003434 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 386585003435 Walker A/P-loop; other site 386585003436 ATP binding site [chemical binding]; other site 386585003437 Q-loop/lid; other site 386585003438 ABC transporter signature motif; other site 386585003439 Walker B; other site 386585003440 D-loop; other site 386585003441 H-loop/switch region; other site 386585003442 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 386585003443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585003444 dimer interface [polypeptide binding]; other site 386585003445 conserved gate region; other site 386585003446 putative PBP binding loops; other site 386585003447 ABC-ATPase subunit interface; other site 386585003448 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 386585003449 active site 386585003450 dimer interface [polypeptide binding]; other site 386585003451 non-prolyl cis peptide bond; other site 386585003452 insertion regions; other site 386585003453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585003454 substrate binding pocket [chemical binding]; other site 386585003455 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 386585003456 membrane-bound complex binding site; other site 386585003457 hinge residues; other site 386585003458 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 386585003459 Fimbrial protein; Region: Fimbrial; cl01416 386585003460 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 386585003461 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585003462 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585003463 similar to outer membrane protein YcbS 386585003464 Fimbrial protein; Region: Fimbrial; cl01416 386585003465 Fimbrial protein; Region: Fimbrial; cl01416 386585003466 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585003467 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585003468 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 386585003469 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 386585003470 quinone interaction residues [chemical binding]; other site 386585003471 active site 386585003472 catalytic residues [active] 386585003473 FMN binding site [chemical binding]; other site 386585003474 substrate binding site [chemical binding]; other site 386585003475 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 386585003476 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 386585003477 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 386585003478 MOSC domain; Region: MOSC; pfam03473 386585003479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585003480 catalytic loop [active] 386585003481 iron binding site [ion binding]; other site 386585003482 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 386585003483 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 386585003484 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 386585003485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585003486 S-adenosylmethionine binding site [chemical binding]; other site 386585003487 ABC transporter ATPase component; Reviewed; Region: PRK11147 386585003488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585003489 ABC transporter; Region: ABC_tran_2; pfam12848 386585003490 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585003491 type III secretion system chaperone SseA; Provisional; Region: PRK15365 386585003492 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 386585003493 Paraquat-inducible protein A; Region: PqiA; pfam04403 386585003494 Paraquat-inducible protein A; Region: PqiA; pfam04403 386585003495 paraquat-inducible protein B; Provisional; Region: PRK10807 386585003496 mce related protein; Region: MCE; pfam02470 386585003497 mce related protein; Region: MCE; pfam02470 386585003498 mce related protein; Region: MCE; pfam02470 386585003499 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 386585003500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 386585003501 ribosome modulation factor; Provisional; Region: PRK14563 386585003502 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 386585003503 active site 1 [active] 386585003504 dimer interface [polypeptide binding]; other site 386585003505 active site 2 [active] 386585003506 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 386585003507 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 386585003508 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 386585003509 outer membrane protein A; Reviewed; Region: PRK10808 386585003510 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 386585003511 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585003512 ligand binding site [chemical binding]; other site 386585003513 cell division inhibitor SulA; Region: sula; TIGR00623 386585003514 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 386585003515 TfoX C-terminal domain; Region: TfoX_C; pfam04994 386585003516 TIGR01666 family membrane protein; Region: YCCS 386585003517 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 386585003518 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 386585003519 Predicted membrane protein [Function unknown]; Region: COG3304 386585003520 Domain of unknown function (DUF307); Region: DUF307; pfam03733 386585003521 Domain of unknown function (DUF307); Region: DUF307; pfam03733 386585003522 DNA helicase IV; Provisional; Region: helD; PRK11054 386585003523 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 386585003524 Part of AAA domain; Region: AAA_19; pfam13245 386585003525 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 386585003526 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 386585003527 active site 386585003528 dimer interfaces [polypeptide binding]; other site 386585003529 catalytic residues [active] 386585003530 hypothetical protein; Provisional; Region: PRK03641 386585003531 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 386585003532 heat shock protein HspQ; Provisional; Region: PRK14129 386585003533 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 386585003534 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 386585003535 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 386585003536 putative RNA binding site [nucleotide binding]; other site 386585003537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585003538 S-adenosylmethionine binding site [chemical binding]; other site 386585003539 Acylphosphatase; Region: Acylphosphatase; cl00551 386585003540 sulfur transfer protein TusE; Provisional; Region: PRK11508 386585003541 YccA-like proteins; Region: YccA_like; cd10433 386585003542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 386585003543 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585003544 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 386585003545 dimer interface [polypeptide binding]; other site 386585003546 active site 386585003547 Int/Topo IB signature motif; other site 386585003548 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 386585003549 active site 386585003550 substrate binding site [chemical binding]; other site 386585003551 catalytic site [active] 386585003552 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 386585003553 DicB protein; Region: DicB; pfam05358 386585003554 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 386585003555 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 386585003556 transcriptional repressor DicA; Reviewed; Region: PRK09706 386585003557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585003558 non-specific DNA binding site [nucleotide binding]; other site 386585003559 salt bridge; other site 386585003560 sequence-specific DNA binding site [nucleotide binding]; other site 386585003561 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585003562 primosomal protein DnaI; Provisional; Region: PRK02854 386585003563 putative replication protein; Provisional; Region: PRK12377 386585003564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585003565 Walker A motif; other site 386585003566 ATP binding site [chemical binding]; other site 386585003567 Walker B motif; other site 386585003568 arginine finger; other site 386585003569 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 386585003570 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 386585003571 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 386585003572 Hok/gef family; Region: HOK_GEF; pfam01848 386585003573 Protein of unknown function (DUF968); Region: DUF968; pfam06147 386585003574 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 386585003575 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 386585003576 CAAX protease self-immunity; Region: Abi; pfam02517 386585003577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585003578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585003579 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585003580 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585003581 Transposase; Region: HTH_Tnp_1; cl17663 386585003582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585003583 putative transposase OrfB; Reviewed; Region: PHA02517 386585003584 HTH-like domain; Region: HTH_21; pfam13276 386585003585 Integrase core domain; Region: rve; pfam00665 386585003586 Integrase core domain; Region: rve_3; pfam13683 386585003587 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585003588 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585003589 catalytic residues [active] 386585003590 Lysis protein S; Region: Lysis_S; pfam04971 386585003591 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 386585003592 Transposase; Region: HTH_Tnp_1; pfam01527 386585003593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585003594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585003595 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585003596 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585003597 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585003598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585003599 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585003600 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585003601 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585003602 similar to terminase small subunit; probably disrupted by IS insertion 386585003603 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 386585003604 gpW; Region: gpW; pfam02831 386585003605 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 386585003606 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 386585003607 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 386585003608 tandem repeat interface [polypeptide binding]; other site 386585003609 oligomer interface [polypeptide binding]; other site 386585003610 active site residues [active] 386585003611 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 386585003612 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 386585003613 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 386585003614 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 386585003615 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 386585003616 Minor tail protein T; Region: Phage_tail_T; cl05636 386585003617 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585003618 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 386585003619 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585003620 Phage-related protein [Function unknown]; Region: COG4718 386585003621 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585003622 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585003623 MPN+ (JAMM) motif; other site 386585003624 Zinc-binding site [ion binding]; other site 386585003625 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585003626 NlpC/P60 family; Region: NLPC_P60; cl17555 386585003627 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585003628 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 386585003629 E-class dimer interface [polypeptide binding]; other site 386585003630 P-class dimer interface [polypeptide binding]; other site 386585003631 active site 386585003632 Cu2+ binding site [ion binding]; other site 386585003633 Zn2+ binding site [ion binding]; other site 386585003634 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585003635 Putative phage tail protein; Region: Phage-tail_3; pfam13550 386585003636 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 386585003637 Interdomain contacts; other site 386585003638 Cytokine receptor motif; other site 386585003639 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585003640 Fibronectin type III protein; Region: DUF3672; pfam12421 386585003641 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585003642 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585003643 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585003644 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585003645 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585003646 EspF protein repeat; Region: EspF; pfam04806 386585003647 EspF protein repeat; Region: EspF; pfam04806 386585003648 EspF protein repeat; Region: EspF; pfam04806 386585003649 EspF protein repeat; Region: EspF; pfam04806 386585003650 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 386585003651 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 386585003652 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 386585003653 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 386585003654 hydrogenase 1 large subunit; Provisional; Region: PRK10170 386585003655 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 386585003656 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 386585003657 putative substrate-binding site; other site 386585003658 nickel binding site [ion binding]; other site 386585003659 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 386585003660 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 386585003661 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 386585003662 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 386585003663 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 386585003664 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 386585003665 catalytic core [active] 386585003666 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 386585003667 Chain length determinant protein; Region: Wzz; pfam02706 386585003668 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 386585003669 AAA domain; Region: AAA_31; pfam13614 386585003670 Low molecular weight phosphatase family; Region: LMWPc; cd00115 386585003671 active site 386585003672 polysaccharide export protein Wza; Provisional; Region: PRK15078 386585003673 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 386585003674 SLBB domain; Region: SLBB; pfam10531 386585003675 SLBB domain; Region: SLBB; pfam10531 386585003676 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 386585003677 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 386585003678 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 386585003679 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 386585003680 DNA-binding site [nucleotide binding]; DNA binding site 386585003681 RNA-binding motif; other site 386585003682 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 386585003683 DNA-binding site [nucleotide binding]; DNA binding site 386585003684 RNA-binding motif; other site 386585003685 cold shock gene; Provisional; Region: PRK09891 386585003686 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 386585003687 4Fe-4S binding domain; Region: Fer4_5; pfam12801 386585003688 4Fe-4S binding domain; Region: Fer4_5; pfam12801 386585003689 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585003690 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 386585003691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585003692 dimerization interface [polypeptide binding]; other site 386585003693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585003694 dimer interface [polypeptide binding]; other site 386585003695 phosphorylation site [posttranslational modification] 386585003696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585003697 ATP binding site [chemical binding]; other site 386585003698 Mg2+ binding site [ion binding]; other site 386585003699 G-X-G motif; other site 386585003700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585003701 active site 386585003702 phosphorylation site [posttranslational modification] 386585003703 intermolecular recognition site; other site 386585003704 dimerization interface [polypeptide binding]; other site 386585003705 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 386585003706 putative binding surface; other site 386585003707 active site 386585003708 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 386585003709 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 386585003710 putative ligand binding site [chemical binding]; other site 386585003711 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 386585003712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585003713 active site 386585003714 phosphorylation site [posttranslational modification] 386585003715 intermolecular recognition site; other site 386585003716 dimerization interface [polypeptide binding]; other site 386585003717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585003718 DNA binding site [nucleotide binding] 386585003719 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 386585003720 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 386585003721 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 386585003722 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 386585003723 molybdopterin cofactor binding site [chemical binding]; other site 386585003724 substrate binding site [chemical binding]; other site 386585003725 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 386585003726 molybdopterin cofactor binding site; other site 386585003727 chaperone protein TorD; Validated; Region: torD; PRK04976 386585003728 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 386585003729 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 386585003730 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 386585003731 HSP70 interaction site [polypeptide binding]; other site 386585003732 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 386585003733 substrate binding site [polypeptide binding]; other site 386585003734 dimer interface [polypeptide binding]; other site 386585003735 similar to YccE; disrupted by frameshift 386585003736 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 386585003737 catalytic core [active] 386585003738 hypothetical protein; Provisional; Region: PRK10174 386585003739 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 386585003740 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 386585003741 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585003742 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 386585003743 Int/Topo IB signature motif; other site 386585003744 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 386585003745 ASCH domain; Region: ASCH; pfam04266 386585003746 Protein of unknown function (DUF551); Region: DUF551; pfam04448 386585003747 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 386585003748 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 386585003749 DksA-like zinc finger domain containing protein; Region: PHA00080 386585003750 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 386585003751 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 386585003752 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 386585003753 phage recombination protein Bet; Region: bet_lambda; TIGR01913 386585003754 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 386585003755 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 386585003756 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 386585003757 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 386585003758 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 386585003759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585003760 non-specific DNA binding site [nucleotide binding]; other site 386585003761 salt bridge; other site 386585003762 sequence-specific DNA binding site [nucleotide binding]; other site 386585003763 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585003764 Catalytic site [active] 386585003765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585003766 non-specific DNA binding site [nucleotide binding]; other site 386585003767 salt bridge; other site 386585003768 sequence-specific DNA binding site [nucleotide binding]; other site 386585003769 Bacteriophage CII protein; Region: Phage_CII; pfam05269 386585003770 Protein of unknown function (DUF2740); Region: DUF2740; pfam10872 386585003771 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 386585003772 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 386585003773 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 386585003774 Walker A motif; other site 386585003775 ATP binding site [chemical binding]; other site 386585003776 Walker B motif; other site 386585003777 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 386585003778 NinB protein; Region: NinB; pfam05772 386585003779 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 386585003780 NINE Protein; Region: NinE; pfam05322 386585003781 ORF6N domain; Region: ORF6N; pfam10543 386585003782 Phage anti-repressor protein [Transcription]; Region: COG3561 386585003783 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 386585003784 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 386585003785 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 386585003786 Phage NinH protein; Region: Phage_NinH; pfam06322 386585003787 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 386585003788 DNA methylase; Region: N6_N4_Mtase; cl17433 386585003789 Ribosome inactivating protein; Region: RIP; pfam00161 386585003790 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 386585003791 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585003792 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 386585003794 putative transposase OrfB; Reviewed; Region: PHA02517 386585003795 HTH-like domain; Region: HTH_21; pfam13276 386585003796 Integrase core domain; Region: rve; pfam00665 386585003797 Integrase core domain; Region: rve_3; pfam13683 386585003798 Transposase; Region: HTH_Tnp_1; cl17663 386585003799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585003800 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42 and YjhS [Shigella dysenteriae] gi|6759965|gb|AAF28123.1|AF153317_19; disrupted by IS insertion 386585003801 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 386585003802 Protein of unknown function (DUF826); Region: DUF826; pfam05696 386585003803 Lysis protein S; Region: Lysis_S; pfam04971 386585003804 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585003805 catalytic residues [active] 386585003806 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585003807 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585003808 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585003809 Bor protein; Region: Lambda_Bor; pfam06291 386585003810 large terminase protein; Provisional; Region: 17; PHA02533 386585003811 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 386585003812 adaptive-response sensory kinase; Validated; Region: PRK09303 386585003813 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585003814 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585003815 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585003816 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585003817 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 386585003818 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585003819 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585003820 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585003821 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585003822 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585003823 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585003824 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585003825 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 386585003826 Protein of unknown function (DUF499); Region: DUF499; cl19819 386585003827 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 386585003828 Hok/gef family; Region: HOK_GEF; pfam01848 386585003829 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 386585003830 Protein of unknown function (DUF551); Region: DUF551; pfam04448 386585003831 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 386585003832 DksA-like zinc finger domain containing protein; Region: PHA00080 386585003833 Phage anti-repressor protein [Transcription]; Region: COG3561 386585003834 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 386585003835 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 386585003836 uracil-xanthine permease; Region: ncs2; TIGR00801 386585003837 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 386585003838 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 386585003839 putative FMN binding site [chemical binding]; other site 386585003840 pyrimidine utilization protein D; Region: RutD; TIGR03611 386585003841 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585003842 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 386585003843 homotrimer interaction site [polypeptide binding]; other site 386585003844 putative active site [active] 386585003845 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 386585003846 catalytic triad [active] 386585003847 conserved cis-peptide bond; other site 386585003848 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 386585003849 active site 386585003850 dimer interface [polypeptide binding]; other site 386585003851 non-prolyl cis peptide bond; other site 386585003852 insertion regions; other site 386585003853 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 386585003854 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 386585003855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585003856 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 386585003857 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 386585003858 Predicted transcriptional regulator [Transcription]; Region: COG3905 386585003859 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 386585003860 Proline dehydrogenase; Region: Pro_dh; pfam01619 386585003861 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 386585003862 Glutamate binding site [chemical binding]; other site 386585003863 NAD binding site [chemical binding]; other site 386585003864 catalytic residues [active] 386585003865 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 386585003866 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 386585003867 Na binding site [ion binding]; other site 386585003868 FTR1 family protein; Region: TIGR00145 386585003869 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 386585003870 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 386585003871 Imelysin; Region: Peptidase_M75; pfam09375 386585003872 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 386585003873 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 386585003874 hypothetical protein; Provisional; Region: PRK10536 386585003875 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 386585003876 N-glycosyltransferase; Provisional; Region: PRK11204 386585003877 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 386585003878 DXD motif; other site 386585003879 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 386585003880 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 386585003881 putative active site [active] 386585003882 putative metal binding site [ion binding]; other site 386585003883 Hypothetical glycosyl hydrolase family 13; Region: GHL13; pfam14883 386585003884 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 386585003885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585003886 metal binding site [ion binding]; metal-binding site 386585003887 active site 386585003888 I-site; other site 386585003889 phage resistance protein; Provisional; Region: PRK10551 386585003890 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 386585003891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585003892 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 386585003893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 386585003894 DNA binding site [nucleotide binding] 386585003895 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 386585003896 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 386585003897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585003898 NAD(P) binding site [chemical binding]; other site 386585003899 active site 386585003900 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 386585003901 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585003902 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585003903 Fimbrial protein; Region: Fimbrial; cl01416 386585003904 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 386585003905 PapC N-terminal domain; Region: PapC_N; pfam13954 386585003906 Outer membrane usher protein; Region: Usher; pfam00577 386585003907 PapC C-terminal domain; Region: PapC_C; pfam13953 386585003908 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 386585003909 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585003910 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585003911 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585003912 haemagglutination activity domain; Region: Haemagg_act; pfam05860 386585003913 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 386585003914 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 386585003915 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 386585003916 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 386585003917 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 386585003918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585003919 NAD(P) binding site [chemical binding]; other site 386585003920 active site 386585003921 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 386585003922 Phosphopantetheine attachment site; Region: PP-binding; cl09936 386585003923 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 386585003924 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 386585003925 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 386585003926 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 386585003927 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 386585003928 dimer interface [polypeptide binding]; other site 386585003929 active site 386585003930 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 386585003931 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 386585003932 active site 386585003933 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 386585003934 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 386585003935 active site 386585003936 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 386585003937 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 386585003938 Walker A/P-loop; other site 386585003939 ATP binding site [chemical binding]; other site 386585003940 Q-loop/lid; other site 386585003941 ABC transporter signature motif; other site 386585003942 Walker B; other site 386585003943 D-loop; other site 386585003944 H-loop/switch region; other site 386585003945 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 386585003946 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 386585003947 FtsX-like permease family; Region: FtsX; pfam02687 386585003948 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 386585003949 integrase; Provisional; Region: PRK09692 386585003950 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585003951 active site 386585003952 Int/Topo IB signature motif; other site 386585003953 similar to transposase InsA [Escherichia coli plasmid pO157] gi|7444767|pir||T42122 386585003954 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 386585003955 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 386585003956 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 386585003957 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 386585003958 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 386585003959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 386585003960 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 386585003961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585003962 ATP binding site [chemical binding]; other site 386585003963 putative Mg++ binding site [ion binding]; other site 386585003964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585003965 nucleotide binding region [chemical binding]; other site 386585003966 ATP-binding site [chemical binding]; other site 386585003967 similar to IS30 transposase [Escherichia coli] gi|1552823|gb|AAB08675.1 386585003968 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585003969 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585003970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585003971 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585003972 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585003973 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585003974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585003975 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585003976 Transposase; Region: HTH_Tnp_1; pfam01527 386585003977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585003978 similar to transposase; interrupted 386585003979 putative transposase OrfB; Reviewed; Region: PHA02517 386585003980 HTH-like domain; Region: HTH_21; pfam13276 386585003981 Integrase core domain; Region: rve; pfam00665 386585003982 Integrase core domain; Region: rve_3; pfam13683 386585003983 Enterobacterial TraT complement resistance protein; Region: TraT; cl19728 386585003984 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 386585003985 putative active site [active] 386585003986 trimer interface [polypeptide binding]; other site 386585003987 putative active site [active] 386585003988 Zn binding site [ion binding]; other site 386585003989 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 386585003990 Sulfatase; Region: Sulfatase; pfam00884 386585003991 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 386585003992 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 386585003993 alpha-gamma subunit interface [polypeptide binding]; other site 386585003994 beta-gamma subunit interface [polypeptide binding]; other site 386585003995 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 386585003996 gamma-beta subunit interface [polypeptide binding]; other site 386585003997 alpha-beta subunit interface [polypeptide binding]; other site 386585003998 urease subunit alpha; Reviewed; Region: ureC; PRK13207 386585003999 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 386585004000 subunit interactions [polypeptide binding]; other site 386585004001 active site 386585004002 flap region; other site 386585004003 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 386585004004 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 386585004005 dimer interface [polypeptide binding]; other site 386585004006 catalytic residues [active] 386585004007 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 386585004008 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585004009 similar to autosecreted serine protease Pet [enteroaggregative Escherichia coli] gi|3095184|gb|AAC26634.1 386585004010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004011 Transposase; Region: HTH_Tnp_1; pfam01527 386585004012 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 386585004013 Hok/gef family; Region: HOK_GEF; pfam01848 386585004014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004015 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585004016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004017 Transposase; Region: HTH_Tnp_1; pfam01527 386585004018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004019 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585004020 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585004021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004022 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585004023 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585004024 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585004025 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585004026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004027 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585004028 Predicted transcriptional regulator [Transcription]; Region: COG2378 386585004029 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 386585004030 C-C_Bond_Lyase of the TIM-Barrel fold; Region: C-C_Bond_Lyase; pfam15617 386585004031 Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202 386585004032 PELOTA RNA binding domain; Region: PELOTA_1; pfam15608 386585004033 Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202 386585004034 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 386585004035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585004036 active site 386585004037 TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500 386585004038 ATP-grasp in the biosynthetic pathway with Ter operon; Region: ATPgrasp_Ter; pfam15632 386585004039 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 386585004040 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 386585004041 putative metal binding site [ion binding]; other site 386585004042 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 386585004043 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 386585004044 putative metal binding site [ion binding]; other site 386585004045 tellurite resistance protein terB; Region: terB; cd07176 386585004046 putative metal binding site [ion binding]; other site 386585004047 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 386585004048 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 386585004049 putative metal binding site [ion binding]; other site 386585004050 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 386585004051 putative metal binding site [ion binding]; other site 386585004052 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 386585004053 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 386585004054 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585004055 N-terminal plug; other site 386585004056 ligand-binding site [chemical binding]; other site 386585004057 similar to ShiA [Shigella flexneri] gi|5532447|gb|AAD44731.1|AF141323_2 386585004058 similar to part of IS150 transposase gi|790866|gb|AAA96489.1 386585004059 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 386585004060 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 386585004061 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 386585004062 active site 386585004063 TDP-binding site; other site 386585004064 acceptor substrate-binding pocket; other site 386585004065 homodimer interface [polypeptide binding]; other site 386585004066 similar to ferric enterochelin esterase; truncated 386585004067 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 386585004068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 386585004069 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 386585004070 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 386585004071 Helix-turn-helix domain; Region: HTH_39; pfam14090 386585004072 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 386585004073 putative transposase OrfB; Reviewed; Region: PHA02517 386585004074 HTH-like domain; Region: HTH_21; pfam13276 386585004075 Integrase core domain; Region: rve; pfam00665 386585004076 Integrase core domain; Region: rve_3; pfam13683 386585004077 Transposase; Region: HTH_Tnp_1; cl17663 386585004078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004079 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 386585004080 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 386585004081 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 386585004082 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 386585004083 Active Sites [active] 386585004084 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 386585004085 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 386585004086 ParB-like nuclease domain; Region: ParB; smart00470 386585004087 PerC transcriptional activator; Region: PerC; pfam06069 386585004088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004089 Transposase; Region: HTH_Tnp_1; pfam01527 386585004090 Predicted GTPase [General function prediction only]; Region: COG3596 386585004091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585004092 YfjP GTPase; Region: YfjP; cd11383 386585004093 G1 box; other site 386585004094 GTP/Mg2+ binding site [chemical binding]; other site 386585004095 Switch I region; other site 386585004096 G2 box; other site 386585004097 Switch II region; other site 386585004098 G3 box; other site 386585004099 G4 box; other site 386585004100 G5 box; other site 386585004101 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 386585004102 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 386585004103 hypothetical protein; Provisional; Region: PRK09945 386585004104 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 386585004105 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585004106 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585004107 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 386585004108 G1 box; other site 386585004109 GTP/Mg2+ binding site [chemical binding]; other site 386585004110 G2 box; other site 386585004111 Switch I region; other site 386585004112 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 386585004113 G3 box; other site 386585004114 Switch II region; other site 386585004115 G4 box; other site 386585004116 YjcZ-like protein; Region: YjcZ; pfam13990 386585004117 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 386585004118 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 386585004119 active site 386585004120 nucleophile elbow; other site 386585004121 Domain of unknown function (DUF932); Region: DUF932; pfam06067 386585004122 Antirestriction protein; Region: Antirestrict; pfam03230 386585004123 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 386585004124 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 386585004125 MPN+ (JAMM) motif; other site 386585004126 Zinc-binding site [ion binding]; other site 386585004127 Protein of unknown function (DUF987); Region: DUF987; pfam06174 386585004128 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 386585004129 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 386585004130 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 386585004131 Methyltransferase domain; Region: Methyltransf_27; pfam13708 386585004132 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 386585004133 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 386585004134 putative ligand binding site [chemical binding]; other site 386585004135 NAD binding site [chemical binding]; other site 386585004136 dimerization interface [polypeptide binding]; other site 386585004137 catalytic site [active] 386585004138 putative hydrolase; Validated; Region: PRK09248 386585004139 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 386585004140 active site 386585004141 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 386585004142 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 386585004143 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 386585004144 curli assembly protein CsgF; Provisional; Region: PRK10050 386585004145 curli assembly protein CsgE; Provisional; Region: PRK10386 386585004146 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 386585004147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585004148 DNA binding residues [nucleotide binding] 386585004149 dimerization interface [polypeptide binding]; other site 386585004150 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 386585004151 Curlin associated repeat; Region: Curlin_rpt; pfam07012 386585004152 Curlin associated repeat; Region: Curlin_rpt; pfam07012 386585004153 major curlin subunit; Provisional; Region: csgA; PRK10051 386585004154 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 386585004155 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585004156 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 386585004157 putative ADP-ribose binding site [chemical binding]; other site 386585004158 putative active site [active] 386585004159 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 386585004160 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 386585004161 putative active site [active] 386585004162 catalytic site [active] 386585004163 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 386585004164 putative active site [active] 386585004165 catalytic site [active] 386585004166 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 386585004167 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 386585004168 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 386585004169 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 386585004170 Ligand binding site; other site 386585004171 DXD motif; other site 386585004172 lipoprotein; Provisional; Region: PRK10175 386585004173 secY/secA suppressor protein; Provisional; Region: PRK11467 386585004174 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 386585004175 putative acyl-acceptor binding pocket; other site 386585004176 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 386585004177 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 386585004178 active site residue [active] 386585004179 hypothetical protein; Provisional; Region: PRK03757 386585004180 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 386585004181 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 386585004182 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 386585004183 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 386585004184 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 386585004185 DNA damage-inducible protein I; Provisional; Region: PRK10597 386585004186 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 386585004187 active site 386585004188 substrate binding pocket [chemical binding]; other site 386585004189 dimer interface [polypeptide binding]; other site 386585004190 lipoprotein; Provisional; Region: PRK10598 386585004191 glutaredoxin 2; Provisional; Region: PRK10387 386585004192 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 386585004193 C-terminal domain interface [polypeptide binding]; other site 386585004194 GSH binding site (G-site) [chemical binding]; other site 386585004195 catalytic residues [active] 386585004196 putative dimer interface [polypeptide binding]; other site 386585004197 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 386585004198 N-terminal domain interface [polypeptide binding]; other site 386585004199 multidrug resistance protein MdtH; Provisional; Region: PRK11646 386585004200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585004201 putative substrate translocation pore; other site 386585004202 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 386585004203 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 386585004204 hypothetical protein; Provisional; Region: PRK11239 386585004205 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 386585004206 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 386585004207 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 386585004208 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 386585004209 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 386585004210 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 386585004211 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 386585004212 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 386585004213 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 386585004214 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 386585004215 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 386585004216 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 386585004217 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 386585004218 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 386585004219 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 386585004220 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 386585004221 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 386585004222 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 386585004223 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 386585004224 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 386585004225 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 386585004226 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 386585004227 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 386585004228 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 386585004229 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 386585004230 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 386585004231 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 386585004232 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 386585004233 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 386585004234 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 386585004235 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 386585004236 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 386585004237 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 386585004238 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 386585004239 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 386585004240 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 386585004241 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 386585004242 ribonuclease E; Reviewed; Region: rne; PRK10811 386585004243 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 386585004244 homodimer interface [polypeptide binding]; other site 386585004245 oligonucleotide binding site [chemical binding]; other site 386585004246 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 386585004247 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 386585004248 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 386585004249 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 386585004250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585004251 RNA binding surface [nucleotide binding]; other site 386585004252 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 386585004253 active site 386585004254 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 386585004255 active site 386585004256 dimer interface [polypeptide binding]; other site 386585004257 hypothetical protein; Provisional; Region: PRK11193 386585004258 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 386585004259 putative phosphate acyltransferase; Provisional; Region: PRK05331 386585004260 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 386585004261 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 386585004262 dimer interface [polypeptide binding]; other site 386585004263 active site 386585004264 CoA binding pocket [chemical binding]; other site 386585004265 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 386585004266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 386585004267 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 386585004268 NAD(P) binding site [chemical binding]; other site 386585004269 homotetramer interface [polypeptide binding]; other site 386585004270 homodimer interface [polypeptide binding]; other site 386585004271 active site 386585004272 acyl carrier protein; Provisional; Region: acpP; PRK00982 386585004273 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 386585004274 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 386585004275 dimer interface [polypeptide binding]; other site 386585004276 active site 386585004277 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 386585004278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585004279 catalytic residue [active] 386585004280 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 386585004281 dimerization interface [polypeptide binding]; other site 386585004282 thymidylate kinase; Validated; Region: tmk; PRK00698 386585004283 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 386585004284 TMP-binding site; other site 386585004285 ATP-binding site [chemical binding]; other site 386585004286 DNA polymerase III subunit delta'; Validated; Region: PRK07993 386585004287 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 386585004288 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 386585004289 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 386585004290 active site 386585004291 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 386585004292 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 386585004293 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585004294 active site turn [active] 386585004295 phosphorylation site [posttranslational modification] 386585004296 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 386585004297 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585004298 N-terminal plug; other site 386585004299 ligand-binding site [chemical binding]; other site 386585004300 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 386585004301 nucleotide binding site/active site [active] 386585004302 HIT family signature motif; other site 386585004303 catalytic residue [active] 386585004304 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 386585004305 putative dimer interface [polypeptide binding]; other site 386585004306 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 386585004307 Phosphotransferase enzyme family; Region: APH; pfam01636 386585004308 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 386585004309 active site 386585004310 substrate binding site [chemical binding]; other site 386585004311 ATP binding site [chemical binding]; other site 386585004312 beta-hexosaminidase; Provisional; Region: PRK05337 386585004313 hypothetical protein; Provisional; Region: PRK04940 386585004314 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 386585004315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585004316 hypothetical protein; Provisional; Region: PRK11280 386585004317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 386585004318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585004319 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585004320 L,D-transpeptidase; Provisional; Region: PRK10260 386585004321 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585004322 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 386585004323 transcription-repair coupling factor; Provisional; Region: PRK10689 386585004324 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 386585004325 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 386585004326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585004327 ATP binding site [chemical binding]; other site 386585004328 putative Mg++ binding site [ion binding]; other site 386585004329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585004330 nucleotide binding region [chemical binding]; other site 386585004331 ATP-binding site [chemical binding]; other site 386585004332 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 386585004333 Predicted membrane protein [Function unknown]; Region: COG4763 386585004334 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 386585004335 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 386585004336 FtsX-like permease family; Region: FtsX; pfam02687 386585004337 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 386585004338 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 386585004339 Walker A/P-loop; other site 386585004340 ATP binding site [chemical binding]; other site 386585004341 Q-loop/lid; other site 386585004342 ABC transporter signature motif; other site 386585004343 Walker B; other site 386585004344 D-loop; other site 386585004345 H-loop/switch region; other site 386585004346 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 386585004347 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 386585004348 FtsX-like permease family; Region: FtsX; pfam02687 386585004349 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 386585004350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585004351 nucleotide binding site [chemical binding]; other site 386585004352 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 386585004353 NAD+ binding site [chemical binding]; other site 386585004354 substrate binding site [chemical binding]; other site 386585004355 Zn binding site [ion binding]; other site 386585004356 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 386585004357 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 386585004358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585004359 dimer interface [polypeptide binding]; other site 386585004360 conserved gate region; other site 386585004361 putative PBP binding loops; other site 386585004362 ABC-ATPase subunit interface; other site 386585004363 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 386585004364 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585004365 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 386585004366 dimer interface [polypeptide binding]; other site 386585004367 active site 386585004368 Int/Topo IB signature motif; other site 386585004369 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 386585004370 active site 386585004371 substrate binding site [chemical binding]; other site 386585004372 catalytic site [active] 386585004373 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 386585004374 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 386585004375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585004376 sequence-specific DNA binding site [nucleotide binding]; other site 386585004377 salt bridge; other site 386585004378 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585004379 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 386585004380 Pyocin large subunit [General function prediction only]; Region: COG5529 386585004381 primosomal protein DnaI; Provisional; Region: PRK02854 386585004382 Replication protein P; Region: Phage_lambda_P; pfam06992 386585004383 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 386585004384 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 386585004385 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 386585004386 Protein of unknown function (DUF551); Region: DUF551; pfam04448 386585004387 Hok/gef family; Region: HOK_GEF; pfam01848 386585004388 Protein of unknown function (DUF968); Region: DUF968; pfam06147 386585004389 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 386585004390 Antitermination protein; Region: Antiterm; pfam03589 386585004391 Antitermination protein; Region: Antiterm; pfam03589 386585004392 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585004393 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585004394 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 386585004395 Protein of unknown function (DUF826); Region: DUF826; pfam05696 386585004396 Lysis protein S; Region: Lysis_S; pfam04971 386585004397 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585004398 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585004399 catalytic residues [active] 386585004400 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585004401 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585004402 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585004403 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 386585004404 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585004405 active site 386585004406 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 386585004407 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 386585004408 Phage Terminase; Region: Terminase_1; cl19862 386585004409 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 386585004410 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 386585004411 Phage capsid family; Region: Phage_capsid; pfam05065 386585004412 Phage-related protein [Function unknown]; Region: COG4695 386585004413 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 386585004414 oligomerization interface [polypeptide binding]; other site 386585004415 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 386585004416 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 386585004417 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 386585004418 Immunoglobulin I-set domain; Region: I-set; pfam07679 386585004419 Immunoglobulin domain; Region: Ig_2; pfam13895 386585004420 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 386585004421 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 386585004422 similar to tail length tape measure protein; disrupted by frameshift 386585004423 Phage-related protein [Function unknown]; Region: COG4718 386585004424 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585004425 Mnt; Region: mnt; PHA01513 386585004426 Arc-like DNA binding domain; Region: Arc; pfam03869 386585004427 Prophage antirepressor [Transcription]; Region: COG3617 386585004428 BRO family, N-terminal domain; Region: Bro-N; smart01040 386585004429 Phage anti-repressor protein [Transcription]; Region: COG3561 386585004430 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585004431 MPN+ (JAMM) motif; other site 386585004432 Zinc-binding site [ion binding]; other site 386585004433 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585004434 NlpC/P60 family; Region: NLPC_P60; cl17555 386585004435 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585004436 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 386585004437 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585004438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585004439 SopA-like central domain; Region: SopA; pfam13981 386585004440 SopA-like catalytic domain; Region: SopA_C; pfam13979 386585004441 IS2 transposase TnpB; Reviewed; Region: PRK09409 386585004442 HTH-like domain; Region: HTH_21; pfam13276 386585004443 Integrase core domain; Region: rve; pfam00665 386585004444 Integrase core domain; Region: rve_3; pfam13683 386585004445 Transposase; Region: HTH_Tnp_1; cl17663 386585004446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 386585004448 Transposase, Mutator family; Region: Transposase_mut; cl19537 386585004449 type III secretion protein GogB; Provisional; Region: PRK15386 386585004450 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 386585004451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585004452 dimer interface [polypeptide binding]; other site 386585004453 conserved gate region; other site 386585004454 putative PBP binding loops; other site 386585004455 ABC-ATPase subunit interface; other site 386585004456 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 386585004457 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 386585004458 Walker A/P-loop; other site 386585004459 ATP binding site [chemical binding]; other site 386585004460 Q-loop/lid; other site 386585004461 ABC transporter signature motif; other site 386585004462 Walker B; other site 386585004463 D-loop; other site 386585004464 H-loop/switch region; other site 386585004465 TOBE domain; Region: TOBE_2; pfam08402 386585004466 peptidase T-like protein; Region: PepT-like; TIGR01883 386585004467 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 386585004468 metal binding site [ion binding]; metal-binding site 386585004469 dimer interface [polypeptide binding]; other site 386585004470 Uncharacterized conserved protein [Function unknown]; Region: COG2850 386585004471 integrase; Provisional; Region: PRK09692 386585004472 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585004473 active site 386585004474 Int/Topo IB signature motif; other site 386585004475 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 386585004476 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 386585004477 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 386585004478 ssDNA binding site [nucleotide binding]; other site 386585004479 dimer interface [polypeptide binding]; other site 386585004480 tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585004481 PerC transcriptional activator; Region: PerC; pfam06069 386585004482 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 386585004483 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 386585004484 Phage head maturation protease [General function prediction only]; Region: COG3740 386585004485 Phage-related protein [Function unknown]; Region: COG4695 386585004486 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 386585004487 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 386585004488 oligomerization interface [polypeptide binding]; other site 386585004489 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585004490 active site 386585004491 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 386585004492 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 386585004493 Phage Terminase; Region: Terminase_1; cl19862 386585004494 sensor protein PhoQ; Provisional; Region: PRK10815 386585004495 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 386585004496 HAMP domain; Region: HAMP; pfam00672 386585004497 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 386585004498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585004499 ATP binding site [chemical binding]; other site 386585004500 Mg2+ binding site [ion binding]; other site 386585004501 G-X-G motif; other site 386585004502 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 386585004503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585004504 active site 386585004505 phosphorylation site [posttranslational modification] 386585004506 intermolecular recognition site; other site 386585004507 dimerization interface [polypeptide binding]; other site 386585004508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585004509 DNA binding site [nucleotide binding] 386585004510 adenylosuccinate lyase; Provisional; Region: PRK09285 386585004511 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 386585004512 tetramer interface [polypeptide binding]; other site 386585004513 active site 386585004514 putative lysogenization regulator; Reviewed; Region: PRK00218 386585004515 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 386585004516 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 386585004517 Ligand Binding Site [chemical binding]; other site 386585004518 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 386585004519 nudix motif; other site 386585004520 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 386585004521 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 386585004522 probable active site [active] 386585004523 isocitrate dehydrogenase; Reviewed; Region: PRK07006 386585004524 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 386585004525 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585004526 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 386585004527 dimer interface [polypeptide binding]; other site 386585004528 active site 386585004529 Int/Topo IB signature motif; other site 386585004530 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 386585004531 Replication protein P; Region: Phage_lambda_P; pfam06992 386585004532 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 386585004533 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 386585004534 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 386585004535 catalytic residues [active] 386585004536 catalytic nucleophile [active] 386585004537 Recombinase; Region: Recombinase; pfam07508 386585004538 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 386585004539 hypothetical protein; Provisional; Region: PRK09741 386585004540 prophage protein NinE; Provisional; Region: PRK09689 386585004541 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 386585004542 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 386585004543 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 386585004544 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 386585004545 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585004546 catalytic residue [active] 386585004547 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585004548 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 386585004549 Bor protein; Region: Lambda_Bor; pfam06291 386585004550 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 386585004551 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 386585004552 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 386585004553 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 386585004554 gpW; Region: gpW; pfam02831 386585004555 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 386585004556 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 386585004557 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 386585004558 tandem repeat interface [polypeptide binding]; other site 386585004559 oligomer interface [polypeptide binding]; other site 386585004560 active site residues [active] 386585004561 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 386585004562 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 386585004563 DNA packaging protein FI; Region: Packaging_FI; pfam14000 386585004564 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 386585004565 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 386585004566 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 386585004567 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 386585004568 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 386585004569 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 386585004570 Minor tail protein T; Region: Phage_tail_T; pfam06223 386585004571 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585004572 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 386585004573 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 386585004574 Phage-related protein [Function unknown]; Region: COG4718 386585004575 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585004576 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585004577 MPN+ (JAMM) motif; other site 386585004578 Zinc-binding site [ion binding]; other site 386585004579 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585004580 NlpC/P60 family; Region: NLPC_P60; cl17555 386585004581 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585004582 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585004583 Putative phage tail protein; Region: Phage-tail_3; pfam13550 386585004584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 386585004585 Interdomain contacts; other site 386585004586 Cytokine receptor motif; other site 386585004587 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585004588 Fibronectin type III protein; Region: DUF3672; pfam12421 386585004589 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585004590 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585004591 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 386585004592 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 386585004593 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 386585004594 Phage Tail Collar Domain; Region: Collar; pfam07484 386585004595 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 386585004596 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 386585004597 dimanganese center [ion binding]; other site 386585004598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 386585004599 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 386585004600 dimerization interface [polypeptide binding]; other site 386585004601 metal binding site [ion binding]; metal-binding site 386585004602 General stress protein [General function prediction only]; Region: GsiB; COG3729 386585004603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 386585004604 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 386585004605 Transposase; Region: HTH_Tnp_1; pfam01527 386585004606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004608 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585004609 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585004610 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585004611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004612 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585004613 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585004614 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585004615 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585004616 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 386585004617 TAP-like protein; Region: Abhydrolase_4; pfam08386 386585004618 outer membrane protease; Reviewed; Region: PRK10993 386585004619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585004620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585004621 non-specific DNA binding site [nucleotide binding]; other site 386585004622 salt bridge; other site 386585004623 sequence-specific DNA binding site [nucleotide binding]; other site 386585004624 Transposase; Region: HTH_Tnp_1; cl17663 386585004625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004626 putative transposase OrfB; Reviewed; Region: PHA02517 386585004627 HTH-like domain; Region: HTH_21; pfam13276 386585004628 Integrase core domain; Region: rve; pfam00665 386585004629 Integrase core domain; Region: rve_3; pfam13683 386585004630 Autotransporter beta-domain; Region: Autotransporter; smart00869 386585004631 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 386585004632 cell division inhibitor MinD; Provisional; Region: PRK10818 386585004633 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 386585004634 P-loop; other site 386585004635 ADP binding residues [chemical binding]; other site 386585004636 Switch I; other site 386585004637 Switch II; other site 386585004638 septum formation inhibitor; Reviewed; Region: minC; PRK03511 386585004639 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 386585004640 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 386585004641 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 386585004642 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 386585004643 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 386585004644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 386585004645 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 386585004646 hypothetical protein; Provisional; Region: PRK10691 386585004647 hypothetical protein; Provisional; Region: PRK05170 386585004648 Haemolysin E (HlyE); Region: HlyE; cl11627 386585004649 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 386585004650 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585004651 Catalytic site [active] 386585004652 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 386585004653 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 386585004654 active site 386585004655 DNA binding site [nucleotide binding] 386585004656 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 386585004657 disulfide bond formation protein B; Provisional; Region: PRK01749 386585004658 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 386585004659 fatty acid metabolism regulator; Provisional; Region: PRK04984 386585004660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585004661 DNA-binding site [nucleotide binding]; DNA binding site 386585004662 FadR C-terminal domain; Region: FadR_C; pfam07840 386585004663 SpoVR family protein; Provisional; Region: PRK11767 386585004664 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 386585004665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585004666 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 386585004667 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 386585004668 TrkA-C domain; Region: TrkA_C; pfam02080 386585004669 Transporter associated domain; Region: CorC_HlyC; smart01091 386585004670 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 386585004671 dimer interface [polypeptide binding]; other site 386585004672 catalytic triad [active] 386585004673 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585004674 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585004675 catalytic residue [active] 386585004676 putative transposase OrfB; Reviewed; Region: PHA02517 386585004677 HTH-like domain; Region: HTH_21; pfam13276 386585004678 Integrase core domain; Region: rve; pfam00665 386585004679 Integrase core domain; Region: rve_3; pfam13683 386585004680 Transposase; Region: HTH_Tnp_1; cl17663 386585004681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004682 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 386585004683 Flagellar regulator YcgR; Region: YcgR; pfam07317 386585004684 PilZ domain; Region: PilZ; pfam07238 386585004685 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 386585004686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585004687 N-terminal plug; other site 386585004688 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 386585004689 ligand-binding site [chemical binding]; other site 386585004690 molybdenum transport protein ModD; Provisional; Region: PRK06096 386585004691 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 386585004692 dimerization interface [polypeptide binding]; other site 386585004693 active site 386585004694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 386585004695 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 386585004696 Walker A/P-loop; other site 386585004697 ATP binding site [chemical binding]; other site 386585004698 Q-loop/lid; other site 386585004699 ABC transporter signature motif; other site 386585004700 Walker B; other site 386585004701 D-loop; other site 386585004702 H-loop/switch region; other site 386585004703 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585004704 ABC-ATPase subunit interface; other site 386585004705 dimer interface [polypeptide binding]; other site 386585004706 putative PBP binding regions; other site 386585004707 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 386585004708 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 386585004709 putative metal binding site [ion binding]; other site 386585004710 similar to trehalase; contains frameshift 386585004711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 386585004712 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 386585004713 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585004714 dimerization domain swap beta strand [polypeptide binding]; other site 386585004715 regulatory protein interface [polypeptide binding]; other site 386585004716 active site 386585004717 regulatory phosphorylation site [posttranslational modification]; other site 386585004718 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 386585004719 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 386585004720 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 386585004721 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 386585004722 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 386585004723 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 386585004724 GTP-binding protein YchF; Reviewed; Region: PRK09601 386585004725 YchF GTPase; Region: YchF; cd01900 386585004726 G1 box; other site 386585004727 GTP/Mg2+ binding site [chemical binding]; other site 386585004728 Switch I region; other site 386585004729 G2 box; other site 386585004730 Switch II region; other site 386585004731 G3 box; other site 386585004732 G4 box; other site 386585004733 G5 box; other site 386585004734 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 386585004735 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 386585004736 putative active site [active] 386585004737 catalytic residue [active] 386585004738 hypothetical protein; Provisional; Region: PRK10692 386585004739 putative transporter; Provisional; Region: PRK11660 386585004740 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 386585004741 Sulfate transporter family; Region: Sulfate_transp; pfam00916 386585004742 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 386585004743 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 386585004744 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 386585004745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585004746 active site 386585004747 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 386585004748 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 386585004749 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 386585004750 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 386585004751 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 386585004752 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 386585004753 tRNA; other site 386585004754 putative tRNA binding site [nucleotide binding]; other site 386585004755 putative NADP binding site [chemical binding]; other site 386585004756 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 386585004757 peptide chain release factor 1; Validated; Region: prfA; PRK00591 386585004758 This domain is found in peptide chain release factors; Region: PCRF; smart00937 386585004759 RF-1 domain; Region: RF-1; pfam00472 386585004760 HemK family putative methylases; Region: hemK_fam; TIGR00536 386585004761 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 386585004762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585004763 S-adenosylmethionine binding site [chemical binding]; other site 386585004764 hypothetical protein; Provisional; Region: PRK10278 386585004765 hypothetical protein; Provisional; Region: PRK10941 386585004766 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 386585004767 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 386585004768 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 386585004769 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 386585004770 cation transport regulator; Reviewed; Region: chaB; PRK09582 386585004771 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 386585004772 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 386585004773 putative active site pocket [active] 386585004774 dimerization interface [polypeptide binding]; other site 386585004775 putative catalytic residue [active] 386585004776 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 386585004777 putative invasin; Provisional; Region: PRK10177 386585004778 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 386585004779 transcriptional regulator NarL; Provisional; Region: PRK10651 386585004780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585004781 active site 386585004782 phosphorylation site [posttranslational modification] 386585004783 intermolecular recognition site; other site 386585004784 dimerization interface [polypeptide binding]; other site 386585004785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585004786 DNA binding residues [nucleotide binding] 386585004787 dimerization interface [polypeptide binding]; other site 386585004788 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 386585004789 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 386585004790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585004791 dimerization interface [polypeptide binding]; other site 386585004792 Histidine kinase; Region: HisKA_3; pfam07730 386585004793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585004794 ATP binding site [chemical binding]; other site 386585004795 Mg2+ binding site [ion binding]; other site 386585004796 G-X-G motif; other site 386585004797 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 386585004798 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 386585004799 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 386585004800 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 386585004801 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 386585004802 [4Fe-4S] binding site [ion binding]; other site 386585004803 molybdopterin cofactor binding site [chemical binding]; other site 386585004804 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 386585004805 molybdopterin cofactor binding site; other site 386585004806 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 386585004807 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585004808 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 386585004809 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 386585004810 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 386585004811 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 386585004812 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 386585004813 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 386585004814 putative active site [active] 386585004815 putative substrate binding site [chemical binding]; other site 386585004816 putative cosubstrate binding site; other site 386585004817 catalytic site [active] 386585004818 hypothetical protein; Provisional; Region: PRK01617 386585004819 SEC-C motif; Region: SEC-C; cl19389 386585004820 SEC-C motif; Region: SEC-C; cl19389 386585004821 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 386585004822 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 386585004823 active site 386585004824 nucleophile elbow; other site 386585004825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585004826 active site 386585004827 response regulator of RpoS; Provisional; Region: PRK10693 386585004828 phosphorylation site [posttranslational modification] 386585004829 intermolecular recognition site; other site 386585004830 dimerization interface [polypeptide binding]; other site 386585004831 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 386585004832 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 386585004833 active site 386585004834 tetramer interface; other site 386585004835 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 386585004836 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 386585004837 thymidine kinase; Provisional; Region: PRK04296 386585004838 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 386585004839 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 386585004840 putative catalytic cysteine [active] 386585004841 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 386585004842 putative active site [active] 386585004843 metal binding site [ion binding]; metal-binding site 386585004844 hypothetical protein; Provisional; Region: PRK11111 386585004845 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 386585004846 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 386585004847 peptide binding site [polypeptide binding]; other site 386585004848 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 386585004849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585004850 dimer interface [polypeptide binding]; other site 386585004851 conserved gate region; other site 386585004852 putative PBP binding loops; other site 386585004853 ABC-ATPase subunit interface; other site 386585004854 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 386585004855 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 386585004856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585004857 dimer interface [polypeptide binding]; other site 386585004858 conserved gate region; other site 386585004859 putative PBP binding loops; other site 386585004860 ABC-ATPase subunit interface; other site 386585004861 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 386585004862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585004863 Walker A/P-loop; other site 386585004864 ATP binding site [chemical binding]; other site 386585004865 Q-loop/lid; other site 386585004866 ABC transporter signature motif; other site 386585004867 Walker B; other site 386585004868 D-loop; other site 386585004869 H-loop/switch region; other site 386585004870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585004871 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 386585004872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585004873 Walker A/P-loop; other site 386585004874 ATP binding site [chemical binding]; other site 386585004875 Q-loop/lid; other site 386585004876 ABC transporter signature motif; other site 386585004877 Walker B; other site 386585004878 D-loop; other site 386585004879 H-loop/switch region; other site 386585004880 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585004881 dsDNA-mimic protein; Reviewed; Region: PRK05094 386585004882 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 386585004883 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 386585004884 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 386585004885 putative active site [active] 386585004886 catalytic site [active] 386585004887 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 386585004888 putative active site [active] 386585004889 catalytic site [active] 386585004890 voltage-gated potassium channel; Provisional; Region: PRK10537 386585004891 Ion channel; Region: Ion_trans_2; pfam07885 386585004892 TrkA-N domain; Region: TrkA_N; pfam02254 386585004893 YciI-like protein; Reviewed; Region: PRK11370 386585004894 transport protein TonB; Provisional; Region: PRK10819 386585004895 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 386585004896 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 386585004897 intracellular septation protein A; Reviewed; Region: PRK00259 386585004898 hypothetical protein; Provisional; Region: PRK02868 386585004899 outer membrane protein W; Provisional; Region: PRK10959 386585004900 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 386585004901 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585004902 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 386585004903 dimer interface [polypeptide binding]; other site 386585004904 active site 386585004905 Int/Topo IB signature motif; other site 386585004906 Excisionase-like protein; Region: Exc; pfam07825 386585004907 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 386585004908 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 386585004909 active site 386585004910 catalytic site [active] 386585004911 substrate binding site [chemical binding]; other site 386585004912 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 386585004913 DicB protein; Region: DicB; pfam05358 386585004914 transcriptional repressor DicA; Reviewed; Region: PRK09706 386585004915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585004916 non-specific DNA binding site [nucleotide binding]; other site 386585004917 salt bridge; other site 386585004918 sequence-specific DNA binding site [nucleotide binding]; other site 386585004919 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 386585004920 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585004921 Pyocin large subunit [General function prediction only]; Region: COG5529 386585004922 Helix-turn-helix domain; Region: HTH_36; pfam13730 386585004923 primosomal protein DnaI; Provisional; Region: PRK02854 386585004924 similar to hypothetical 22.1 kDa protein 22.1 KD protein YdaW [Escherichia coli] (gi|3025105|sp|P76066|YDAW_ECOLI) 386585004925 similar to fimbrial minor pilin protein precursor; disrupted by frameshift 386585004926 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 386585004927 Hok/gef family; Region: HOK_GEF; pfam01848 386585004928 Protein of unknown function (DUF968); Region: DUF968; pfam06147 386585004929 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 386585004930 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 386585004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585004932 DNA methylase; Region: N6_N4_Mtase; pfam01555 386585004933 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585004934 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585004935 Lysis protein S; Region: Lysis_S; pfam04971 386585004936 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585004937 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585004938 catalytic residues [active] 386585004939 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585004940 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585004941 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585004942 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 386585004943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585004944 active site 386585004945 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 386585004946 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 386585004947 Phage Terminase; Region: Terminase_1; cl19862 386585004948 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 386585004949 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 386585004950 Phage capsid family; Region: Phage_capsid; pfam05065 386585004951 Phage-related protein [Function unknown]; Region: COG4695 386585004952 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 386585004953 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 386585004954 oligomerization interface [polypeptide binding]; other site 386585004955 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 386585004956 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 386585004957 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 386585004958 Immunoglobulin I-set domain; Region: I-set; pfam07679 386585004959 Immunoglobulin domain; Region: Ig_2; pfam13895 386585004960 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 386585004961 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 386585004962 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585004963 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585004964 tape measure domain; Region: tape_meas_nterm; TIGR02675 386585004965 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585004966 Phage-related protein [Function unknown]; Region: COG4718 386585004967 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585004968 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585004969 Putative phage tail protein; Region: Phage-tail_3; pfam13550 386585004970 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 386585004971 Interdomain contacts; other site 386585004972 Cytokine receptor motif; other site 386585004973 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585004974 Fibronectin type III protein; Region: DUF3672; pfam12421 386585004975 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585004976 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585004977 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585004978 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585004979 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585004980 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585004981 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 386585004982 dimer interface [polypeptide binding]; other site 386585004983 active site 386585004984 Int/Topo IB signature motif; other site 386585004985 hypothetical protein; Provisional; Region: PHA03031 386585004986 similar to transposase; appears to be disrupted 386585004987 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585004988 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585004989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004990 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585004991 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585004992 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585004993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585004994 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585004995 Transposase; Region: HTH_Tnp_1; pfam01527 386585004996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585004997 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585004998 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 386585004999 similar to hypothetical protein [insertion sequence IS630] gi|140943|spP16943|YIS5_SHISO; probably disrupted 386585005000 similar to IS630 hypothetical 39 KD protein gi|140943|spP16943|YIS5_SHISO 386585005001 similar to transposases e.g. [insertion sequence IS3] gi|7429030|pir||TQECI3 386585005002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 386585005003 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 386585005004 dimerization interface [polypeptide binding]; other site 386585005005 metal binding site [ion binding]; metal-binding site 386585005006 General stress protein [General function prediction only]; Region: GsiB; COG3729 386585005007 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 386585005008 substrate binding site [chemical binding]; other site 386585005009 active site 386585005010 catalytic residues [active] 386585005011 heterodimer interface [polypeptide binding]; other site 386585005012 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 386585005013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585005014 catalytic residue [active] 386585005015 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 386585005016 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 386585005017 active site 386585005018 ribulose/triose binding site [chemical binding]; other site 386585005019 phosphate binding site [ion binding]; other site 386585005020 substrate (anthranilate) binding pocket [chemical binding]; other site 386585005021 product (indole) binding pocket [chemical binding]; other site 386585005022 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 386585005023 active site 386585005024 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 386585005025 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 386585005026 glutamine binding [chemical binding]; other site 386585005027 catalytic triad [active] 386585005028 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 386585005029 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 386585005030 anthranilate synthase component I; Provisional; Region: PRK13564 386585005031 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 386585005032 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 386585005033 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 386585005034 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 386585005035 active site 386585005036 hypothetical protein; Provisional; Region: PRK11630 386585005037 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 386585005038 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 386585005039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585005040 RNA binding surface [nucleotide binding]; other site 386585005041 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 386585005042 probable active site [active] 386585005043 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 386585005044 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 386585005045 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 386585005046 homodimer interface [polypeptide binding]; other site 386585005047 Walker A motif; other site 386585005048 ATP binding site [chemical binding]; other site 386585005049 hydroxycobalamin binding site [chemical binding]; other site 386585005050 Walker B motif; other site 386585005051 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 386585005052 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 386585005053 NADP binding site [chemical binding]; other site 386585005054 homodimer interface [polypeptide binding]; other site 386585005055 active site 386585005056 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 386585005057 putative inner membrane peptidase; Provisional; Region: PRK11778 386585005058 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 386585005059 tandem repeat interface [polypeptide binding]; other site 386585005060 oligomer interface [polypeptide binding]; other site 386585005061 active site residues [active] 386585005062 hypothetical protein; Provisional; Region: PRK11037 386585005063 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 386585005064 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 386585005065 active site 386585005066 interdomain interaction site; other site 386585005067 putative metal-binding site [ion binding]; other site 386585005068 nucleotide binding site [chemical binding]; other site 386585005069 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 386585005070 domain I; other site 386585005071 DNA binding groove [nucleotide binding] 386585005072 phosphate binding site [ion binding]; other site 386585005073 domain II; other site 386585005074 domain III; other site 386585005075 nucleotide binding site [chemical binding]; other site 386585005076 catalytic site [active] 386585005077 domain IV; other site 386585005078 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 386585005079 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 386585005080 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 386585005081 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 386585005082 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 386585005083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585005084 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 386585005085 substrate binding site [chemical binding]; other site 386585005086 putative dimerization interface [polypeptide binding]; other site 386585005087 aconitate hydratase; Validated; Region: PRK09277 386585005088 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 386585005089 substrate binding site [chemical binding]; other site 386585005090 ligand binding site [chemical binding]; other site 386585005091 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 386585005092 substrate binding site [chemical binding]; other site 386585005093 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 386585005094 dimerization interface [polypeptide binding]; other site 386585005095 active site 386585005096 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 386585005097 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 386585005098 active site 386585005099 Predicted membrane protein [Function unknown]; Region: COG3771 386585005100 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 386585005101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585005102 TPR motif; other site 386585005103 binding surface 386585005104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585005105 binding surface 386585005106 TPR motif; other site 386585005107 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 386585005108 active site 386585005109 dimer interface [polypeptide binding]; other site 386585005110 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 386585005111 putative rRNA binding site [nucleotide binding]; other site 386585005112 lipoprotein; Provisional; Region: PRK10540 386585005113 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 386585005114 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 386585005115 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585005116 hypothetical protein; Provisional; Region: PRK13658 386585005117 RNase II stability modulator; Provisional; Region: PRK10060 386585005118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585005119 putative active site [active] 386585005120 heme pocket [chemical binding]; other site 386585005121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585005122 metal binding site [ion binding]; metal-binding site 386585005123 active site 386585005124 I-site; other site 386585005125 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585005126 exoribonuclease II; Provisional; Region: PRK05054 386585005127 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 386585005128 RNB domain; Region: RNB; pfam00773 386585005129 S1 RNA binding domain; Region: S1; pfam00575 386585005130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 386585005131 Uncharacterized conserved protein [Function unknown]; Region: COG2128 386585005132 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 386585005133 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 386585005134 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 386585005135 NAD binding site [chemical binding]; other site 386585005136 homotetramer interface [polypeptide binding]; other site 386585005137 homodimer interface [polypeptide binding]; other site 386585005138 substrate binding site [chemical binding]; other site 386585005139 active site 386585005140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 386585005141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585005142 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 386585005143 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585005144 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585005145 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 386585005146 MMPL family; Region: MMPL; cl14618 386585005147 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 386585005148 Outer membrane efflux protein; Region: OEP; pfam02321 386585005149 Outer membrane efflux protein; Region: OEP; pfam02321 386585005150 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 386585005151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585005152 putative substrate translocation pore; other site 386585005153 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 386585005154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585005155 Walker A/P-loop; other site 386585005156 ATP binding site [chemical binding]; other site 386585005157 Q-loop/lid; other site 386585005158 ABC transporter signature motif; other site 386585005159 Walker B; other site 386585005160 D-loop; other site 386585005161 H-loop/switch region; other site 386585005162 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 386585005163 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585005164 Walker A/P-loop; other site 386585005165 ATP binding site [chemical binding]; other site 386585005166 Q-loop/lid; other site 386585005167 ABC transporter signature motif; other site 386585005168 Walker B; other site 386585005169 D-loop; other site 386585005170 H-loop/switch region; other site 386585005171 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585005172 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 386585005173 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 386585005174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005175 dimer interface [polypeptide binding]; other site 386585005176 conserved gate region; other site 386585005177 putative PBP binding loops; other site 386585005178 ABC-ATPase subunit interface; other site 386585005179 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 386585005180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005181 dimer interface [polypeptide binding]; other site 386585005182 conserved gate region; other site 386585005183 putative PBP binding loops; other site 386585005184 ABC-ATPase subunit interface; other site 386585005185 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 386585005186 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 386585005187 peptide binding site [polypeptide binding]; other site 386585005188 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 386585005189 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585005190 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 386585005191 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 386585005192 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 386585005193 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 386585005194 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 386585005195 catalytic triad [active] 386585005196 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 386585005197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585005198 non-specific DNA binding site [nucleotide binding]; other site 386585005199 salt bridge; other site 386585005200 sequence-specific DNA binding site [nucleotide binding]; other site 386585005201 Cupin domain; Region: Cupin_2; pfam07883 386585005202 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 386585005203 NAD(P) binding site [chemical binding]; other site 386585005204 catalytic residues [active] 386585005205 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 386585005206 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 386585005207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585005208 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 386585005209 inhibitor-cofactor binding pocket; inhibition site 386585005210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585005211 catalytic residue [active] 386585005212 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 386585005213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585005214 Walker A motif; other site 386585005215 ATP binding site [chemical binding]; other site 386585005216 Walker B motif; other site 386585005217 arginine finger; other site 386585005218 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 386585005219 phage shock protein PspA; Provisional; Region: PRK10698 386585005220 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 386585005221 phage shock protein B; Provisional; Region: pspB; PRK09458 386585005222 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 386585005223 phage shock protein C; Region: phageshock_pspC; TIGR02978 386585005224 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 386585005225 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 386585005226 active site residue [active] 386585005227 similar to polysaccharide hydrolase; disrupted by frameshift 386585005228 similar to transport periplasmic protein; disrupted by frameshift 386585005229 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 386585005230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005231 dimer interface [polypeptide binding]; other site 386585005232 conserved gate region; other site 386585005233 putative PBP binding loops; other site 386585005234 ABC-ATPase subunit interface; other site 386585005235 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 386585005236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005237 dimer interface [polypeptide binding]; other site 386585005238 conserved gate region; other site 386585005239 putative PBP binding loops; other site 386585005240 ABC-ATPase subunit interface; other site 386585005241 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585005242 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 386585005243 putative NAD(P) binding site [chemical binding]; other site 386585005244 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 386585005245 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 386585005246 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 386585005247 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 386585005248 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 386585005249 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 386585005250 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 386585005251 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 386585005252 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 386585005253 beta-phosphoglucomutase; Region: bPGM; TIGR01990 386585005254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585005255 motif II; other site 386585005256 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 386585005257 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 386585005258 Walker A/P-loop; other site 386585005259 ATP binding site [chemical binding]; other site 386585005260 Q-loop/lid; other site 386585005261 ABC transporter signature motif; other site 386585005262 Walker B; other site 386585005263 D-loop; other site 386585005264 H-loop/switch region; other site 386585005265 TOBE domain; Region: TOBE_2; pfam08402 386585005266 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 386585005267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 386585005268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585005269 DNA binding site [nucleotide binding] 386585005270 domain linker motif; other site 386585005271 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 386585005272 putative dimerization interface [polypeptide binding]; other site 386585005273 putative ligand binding site [chemical binding]; other site 386585005274 Predicted ATPase [General function prediction only]; Region: COG3106 386585005275 hypothetical protein; Provisional; Region: PRK05415 386585005276 Predicted membrane protein [Function unknown]; Region: COG3768 386585005277 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 386585005278 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 386585005279 putative aromatic amino acid binding site; other site 386585005280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585005281 putative active site [active] 386585005282 heme pocket [chemical binding]; other site 386585005283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585005284 Walker A motif; other site 386585005285 ATP binding site [chemical binding]; other site 386585005286 Walker B motif; other site 386585005287 arginine finger; other site 386585005288 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 386585005289 dimer interface [polypeptide binding]; other site 386585005290 catalytic triad [active] 386585005291 peroxidatic and resolving cysteines [active] 386585005292 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 386585005293 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 386585005294 active site 386585005295 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 386585005296 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 386585005297 putative active site [active] 386585005298 Zn binding site [ion binding]; other site 386585005299 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 386585005300 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 386585005301 putative NAD(P) binding site [chemical binding]; other site 386585005302 similar to E.coli K-12 hypothetical protein; disrupted by frameshift 386585005303 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 386585005304 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 386585005305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585005306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585005307 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 386585005308 putative effector binding pocket; other site 386585005309 putative dimerization interface [polypeptide binding]; other site 386585005310 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 386585005311 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 386585005312 peptide binding site [polypeptide binding]; other site 386585005313 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 386585005314 Mechanosensitive ion channel; Region: MS_channel; pfam00924 386585005315 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 386585005316 universal stress protein UspE; Provisional; Region: PRK11175 386585005317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585005318 Ligand Binding Site [chemical binding]; other site 386585005319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585005320 Ligand Binding Site [chemical binding]; other site 386585005321 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 386585005322 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 386585005323 ligand binding site [chemical binding]; other site 386585005324 flexible hinge region; other site 386585005325 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 386585005326 putative switch regulator; other site 386585005327 non-specific DNA interactions [nucleotide binding]; other site 386585005328 DNA binding site [nucleotide binding] 386585005329 sequence specific DNA binding site [nucleotide binding]; other site 386585005330 putative cAMP binding site [chemical binding]; other site 386585005331 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 386585005332 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 386585005333 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 386585005334 DNA binding site [nucleotide binding] 386585005335 active site 386585005336 AbgT putative transporter family; Region: ABG_transport; cl17431 386585005337 putative transposase OrfB; Reviewed; Region: PHA02517 386585005338 HTH-like domain; Region: HTH_21; pfam13276 386585005339 Integrase core domain; Region: rve; pfam00665 386585005340 Integrase core domain; Region: rve_3; pfam13683 386585005341 Transposase; Region: HTH_Tnp_1; cl17663 386585005342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585005343 AbgT putative transporter family; Region: ABG_transport; cl17431 386585005344 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 386585005345 amidohydrolase; Region: amidohydrolases; TIGR01891 386585005346 putative metal binding site [ion binding]; other site 386585005347 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 386585005348 amidohydrolase; Region: amidohydrolases; TIGR01891 386585005349 putative metal binding site [ion binding]; other site 386585005350 dimer interface [polypeptide binding]; other site 386585005351 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 386585005352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585005353 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 386585005354 putative substrate binding pocket [chemical binding]; other site 386585005355 putative dimerization interface [polypeptide binding]; other site 386585005356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 386585005357 Smr domain; Region: Smr; pfam01713 386585005358 PAS domain S-box; Region: sensory_box; TIGR00229 386585005359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585005360 putative active site [active] 386585005361 heme pocket [chemical binding]; other site 386585005362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585005363 metal binding site [ion binding]; metal-binding site 386585005364 active site 386585005365 I-site; other site 386585005366 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 386585005367 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 386585005368 Cl binding site [ion binding]; other site 386585005369 oligomer interface [polypeptide binding]; other site 386585005370 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 386585005371 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 386585005372 ATP binding site [chemical binding]; other site 386585005373 Mg++ binding site [ion binding]; other site 386585005374 motif III; other site 386585005375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585005376 nucleotide binding region [chemical binding]; other site 386585005377 ATP-binding site [chemical binding]; other site 386585005378 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 386585005379 putative RNA binding site [nucleotide binding]; other site 386585005380 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 386585005381 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 386585005382 Ligand Binding Site [chemical binding]; other site 386585005383 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 386585005384 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585005385 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 386585005386 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 386585005387 Int/Topo IB signature motif; other site 386585005388 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 386585005389 Protein of unknown function (DUF1187); Region: DUF1187; cl11638 386585005390 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 386585005391 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 386585005392 exonuclease VIII; Reviewed; Region: PRK09709 386585005393 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 386585005394 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 386585005395 hypothetical protein; Reviewed; Region: PRK09790 386585005396 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 386585005397 Superinfection exclusion protein B; Region: SieB; pfam14163 386585005398 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 386585005399 UBA-like domain; Region: UBA_4; pfam14555 386585005400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585005401 sequence-specific DNA binding site [nucleotide binding]; other site 386585005402 transcriptional repressor DicA; Reviewed; Region: PRK09706 386585005403 salt bridge; other site 386585005404 Helix-turn-helix domain; Region: HTH_17; pfam12728 386585005405 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585005406 primosomal protein DnaI; Provisional; Region: PRK02854 386585005407 putative replication protein; Provisional; Region: PRK12377 386585005408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585005409 Walker A motif; other site 386585005410 ATP binding site [chemical binding]; other site 386585005411 Walker B motif; other site 386585005412 arginine finger; other site 386585005413 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 386585005414 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 386585005415 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 386585005416 cofactor binding site; other site 386585005417 DNA binding site [nucleotide binding] 386585005418 substrate interaction site [chemical binding]; other site 386585005419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 386585005420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585005421 ATP binding site [chemical binding]; other site 386585005422 Mg2+ binding site [ion binding]; other site 386585005423 G-X-G motif; other site 386585005424 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 386585005425 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 386585005426 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 386585005427 tellurite resistance protein terB; Region: terB; cd07176 386585005428 putative metal binding site [ion binding]; other site 386585005429 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 386585005430 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585005431 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585005432 Lysis protein S; Region: Lysis_S; pfam04971 386585005433 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585005434 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585005435 catalytic residues [active] 386585005436 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585005437 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585005438 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585005439 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 386585005440 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585005441 active site 386585005442 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 386585005443 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 386585005444 Phage Terminase; Region: Terminase_1; cl19862 386585005445 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 386585005446 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 386585005447 Phage capsid family; Region: Phage_capsid; pfam05065 386585005448 Phage-related protein [Function unknown]; Region: COG4695 386585005449 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 386585005450 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 386585005451 oligomerization interface [polypeptide binding]; other site 386585005452 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 386585005453 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 386585005454 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 386585005455 Immunoglobulin I-set domain; Region: I-set; pfam07679 386585005456 Immunoglobulin domain; Region: Ig; cd00096 386585005457 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 386585005458 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 386585005459 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585005460 tape measure domain; Region: tape_meas_nterm; TIGR02675 386585005461 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585005462 Phage-related protein [Function unknown]; Region: COG4718 386585005463 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585005464 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585005465 MPN+ (JAMM) motif; other site 386585005466 Zinc-binding site [ion binding]; other site 386585005467 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585005468 NlpC/P60 family; Region: NLPC_P60; cl17555 386585005469 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585005470 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 386585005471 E-class dimer interface [polypeptide binding]; other site 386585005472 P-class dimer interface [polypeptide binding]; other site 386585005473 active site 386585005474 Cu2+ binding site [ion binding]; other site 386585005475 Zn2+ binding site [ion binding]; other site 386585005476 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585005477 Putative phage tail protein; Region: Phage-tail_3; pfam13550 386585005478 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 386585005479 Interdomain contacts; other site 386585005480 Cytokine receptor motif; other site 386585005481 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585005482 Fibronectin type III protein; Region: DUF3672; pfam12421 386585005483 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585005484 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585005485 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585005486 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585005487 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585005488 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585005489 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585005490 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585005491 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585005492 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585005493 Ligand Binding Site [chemical binding]; other site 386585005494 similar to outer membrane protein; disrupted by frameshift 386585005495 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 386585005496 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 386585005497 dimer interface [polypeptide binding]; other site 386585005498 PYR/PP interface [polypeptide binding]; other site 386585005499 TPP binding site [chemical binding]; other site 386585005500 substrate binding site [chemical binding]; other site 386585005501 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 386585005502 Domain of unknown function; Region: EKR; pfam10371 386585005503 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 386585005504 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 386585005505 TPP-binding site [chemical binding]; other site 386585005506 dimer interface [polypeptide binding]; other site 386585005507 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 386585005508 heat-inducible protein; Provisional; Region: PRK10449 386585005509 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 386585005510 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 386585005511 putative ligand binding site [chemical binding]; other site 386585005512 putative NAD binding site [chemical binding]; other site 386585005513 catalytic site [active] 386585005514 hypothetical protein; Provisional; Region: PRK10695 386585005515 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 386585005516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 386585005517 Formin Homology Region 1; Region: Drf_FH1; pfam06346 386585005518 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 386585005519 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 386585005520 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585005521 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585005522 active site 386585005523 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585005524 catalytic tetrad [active] 386585005525 Protein of unknown function (DUF342); Region: DUF342; cl19219 386585005526 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 386585005527 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 386585005528 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 386585005529 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 386585005530 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 386585005531 Putative methyltransferase; Region: Methyltransf_20; pfam12147 386585005532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585005533 S-adenosylmethionine binding site [chemical binding]; other site 386585005534 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 386585005535 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 386585005536 active site 386585005537 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 386585005538 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 386585005539 active site 386585005540 catalytic residues [active] 386585005541 azoreductase; Reviewed; Region: PRK00170 386585005542 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 386585005543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585005544 ATP binding site [chemical binding]; other site 386585005545 putative Mg++ binding site [ion binding]; other site 386585005546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585005547 nucleotide binding region [chemical binding]; other site 386585005548 ATP-binding site [chemical binding]; other site 386585005549 Helicase associated domain (HA2); Region: HA2; pfam04408 386585005550 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 386585005551 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 386585005552 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 386585005553 putative active site [active] 386585005554 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 386585005555 NAD binding site [chemical binding]; other site 386585005556 catalytic residues [active] 386585005557 substrate binding site [chemical binding]; other site 386585005558 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 386585005559 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 386585005560 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 386585005561 cytochrome b561; Provisional; Region: PRK11513 386585005562 hypothetical protein; Provisional; Region: PRK10040 386585005563 small toxic polypeptide; Provisional; Region: PRK09738 386585005564 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 386585005565 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 386585005566 dimer interface [polypeptide binding]; other site 386585005567 ligand binding site [chemical binding]; other site 386585005568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585005569 dimerization interface [polypeptide binding]; other site 386585005570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 386585005571 dimer interface [polypeptide binding]; other site 386585005572 putative CheW interface [polypeptide binding]; other site 386585005573 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 386585005574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585005575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585005576 dimerization interface [polypeptide binding]; other site 386585005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 386585005578 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 386585005579 hypothetical protein; Provisional; Region: PRK11415 386585005580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 386585005581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 386585005582 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 386585005583 putative trimer interface [polypeptide binding]; other site 386585005584 putative CoA binding site [chemical binding]; other site 386585005585 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 386585005586 putative trimer interface [polypeptide binding]; other site 386585005587 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 386585005588 putative CoA binding site [chemical binding]; other site 386585005589 putative trimer interface [polypeptide binding]; other site 386585005590 putative CoA binding site [chemical binding]; other site 386585005591 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 386585005592 gating phenylalanine in ion channel; other site 386585005593 tellurite resistance protein TehB; Provisional; Region: PRK11207 386585005594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585005595 S-adenosylmethionine binding site [chemical binding]; other site 386585005596 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 386585005597 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 386585005598 benzoate transporter; Region: benE; TIGR00843 386585005599 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585005600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585005601 non-specific DNA binding site [nucleotide binding]; other site 386585005602 salt bridge; other site 386585005603 sequence-specific DNA binding site [nucleotide binding]; other site 386585005604 Cupin domain; Region: Cupin_2; pfam07883 386585005605 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 386585005606 Collagenase; Region: DUF3656; pfam12392 386585005607 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 386585005608 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 386585005609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585005610 sequence-specific DNA binding site [nucleotide binding]; other site 386585005611 salt bridge; other site 386585005612 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 386585005613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585005614 DNA-binding site [nucleotide binding]; DNA binding site 386585005615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585005616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585005617 homodimer interface [polypeptide binding]; other site 386585005618 catalytic residue [active] 386585005619 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 386585005620 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 386585005621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585005622 Walker A/P-loop; other site 386585005623 ATP binding site [chemical binding]; other site 386585005624 Q-loop/lid; other site 386585005625 ABC transporter signature motif; other site 386585005626 Walker B; other site 386585005627 D-loop; other site 386585005628 H-loop/switch region; other site 386585005629 TOBE domain; Region: TOBE_2; pfam08402 386585005630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005631 dimer interface [polypeptide binding]; other site 386585005632 conserved gate region; other site 386585005633 putative PBP binding loops; other site 386585005634 ABC-ATPase subunit interface; other site 386585005635 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 386585005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005637 dimer interface [polypeptide binding]; other site 386585005638 conserved gate region; other site 386585005639 putative PBP binding loops; other site 386585005640 ABC-ATPase subunit interface; other site 386585005641 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 386585005642 tetrameric interface [polypeptide binding]; other site 386585005643 NAD binding site [chemical binding]; other site 386585005644 catalytic residues [active] 386585005645 substrate binding site [chemical binding]; other site 386585005646 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 386585005647 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 386585005648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 386585005649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 386585005650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585005651 Coenzyme A binding pocket [chemical binding]; other site 386585005652 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 386585005653 Prostaglandin dehydrogenases; Region: PGDH; cd05288 386585005654 NAD(P) binding site [chemical binding]; other site 386585005655 substrate binding site [chemical binding]; other site 386585005656 dimer interface [polypeptide binding]; other site 386585005657 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 386585005658 DNA-binding site [nucleotide binding]; DNA binding site 386585005659 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 386585005660 FCD domain; Region: FCD; pfam07729 386585005661 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 386585005662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585005663 N-terminal plug; other site 386585005664 ligand-binding site [chemical binding]; other site 386585005665 PQQ-like domain; Region: PQQ_2; pfam13360 386585005666 Domain of unknown function (DUF4221); Region: DUF4221; cl19484 386585005667 L-asparagine permease; Provisional; Region: PRK15049 386585005668 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585005669 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 386585005670 C-terminal domain interface [polypeptide binding]; other site 386585005671 GSH binding site (G-site) [chemical binding]; other site 386585005672 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 386585005673 dimer interface [polypeptide binding]; other site 386585005674 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 386585005675 dimer interface [polypeptide binding]; other site 386585005676 N-terminal domain interface [polypeptide binding]; other site 386585005677 substrate binding pocket (H-site) [chemical binding]; other site 386585005678 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 386585005679 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 386585005680 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 386585005681 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 386585005682 PAAR motif; Region: PAAR_motif; cl15808 386585005683 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585005684 RHS Repeat; Region: RHS_repeat; pfam05593 386585005685 RHS Repeat; Region: RHS_repeat; pfam05593 386585005686 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585005687 RHS Repeat; Region: RHS_repeat; pfam05593 386585005688 RHS Repeat; Region: RHS_repeat; pfam05593 386585005689 Erythromycin esterase; Region: Erythro_esteras; cl17110 386585005690 RHS protein; Region: RHS; pfam03527 386585005691 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585005692 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 386585005693 similar to H-repeat associated protein; disrupted by frameshift 386585005694 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 386585005695 active site 1 [active] 386585005696 dimer interface [polypeptide binding]; other site 386585005697 hexamer interface [polypeptide binding]; other site 386585005698 active site 2 [active] 386585005699 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 386585005700 N-acetyltransferase; Region: Acetyltransf_2; cl00949 386585005701 hypothetical protein; Provisional; Region: PRK10281 386585005702 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 386585005703 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 386585005704 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 386585005705 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 386585005706 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585005707 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 386585005708 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 386585005709 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 386585005710 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 386585005711 [4Fe-4S] binding site [ion binding]; other site 386585005712 molybdopterin cofactor binding site [chemical binding]; other site 386585005713 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 386585005714 molybdopterin cofactor binding site; other site 386585005715 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 386585005716 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 386585005717 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 386585005718 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 386585005719 Substrate binding site [chemical binding]; other site 386585005720 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 386585005721 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 386585005722 trimer interface [polypeptide binding]; other site 386585005723 eyelet of channel; other site 386585005724 aromatic amino acid exporter; Provisional; Region: PRK11689 386585005725 EamA-like transporter family; Region: EamA; pfam00892 386585005726 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 386585005727 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 386585005728 [4Fe-4S] binding site [ion binding]; other site 386585005729 molybdopterin cofactor binding site; other site 386585005730 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 386585005731 molybdopterin cofactor binding site; other site 386585005732 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 386585005733 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585005734 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 386585005735 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 386585005736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585005737 non-specific DNA binding site [nucleotide binding]; other site 386585005738 salt bridge; other site 386585005739 sequence-specific DNA binding site [nucleotide binding]; other site 386585005740 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 386585005741 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 386585005742 NAD binding site [chemical binding]; other site 386585005743 substrate binding site [chemical binding]; other site 386585005744 catalytic Zn binding site [ion binding]; other site 386585005745 tetramer interface [polypeptide binding]; other site 386585005746 structural Zn binding site [ion binding]; other site 386585005747 malate dehydrogenase; Provisional; Region: PRK13529 386585005748 Malic enzyme, N-terminal domain; Region: malic; pfam00390 386585005749 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 386585005750 NAD(P) binding site [chemical binding]; other site 386585005751 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 386585005752 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 386585005753 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 386585005754 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 386585005755 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585005756 Walker A/P-loop; other site 386585005757 ATP binding site [chemical binding]; other site 386585005758 Q-loop/lid; other site 386585005759 ABC transporter signature motif; other site 386585005760 Walker B; other site 386585005761 D-loop; other site 386585005762 H-loop/switch region; other site 386585005763 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 386585005764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 386585005765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585005766 Walker A/P-loop; other site 386585005767 ATP binding site [chemical binding]; other site 386585005768 Q-loop/lid; other site 386585005769 ABC transporter signature motif; other site 386585005770 Walker B; other site 386585005771 D-loop; other site 386585005772 H-loop/switch region; other site 386585005773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585005774 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 386585005775 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 386585005776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005777 dimer interface [polypeptide binding]; other site 386585005778 conserved gate region; other site 386585005779 putative PBP binding loops; other site 386585005780 ABC-ATPase subunit interface; other site 386585005781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 386585005782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585005783 dimer interface [polypeptide binding]; other site 386585005784 conserved gate region; other site 386585005785 putative PBP binding loops; other site 386585005786 ABC-ATPase subunit interface; other site 386585005787 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 386585005788 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 386585005789 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 386585005790 similar to oxygen sensing protein; disrupted by frameshift 386585005791 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 386585005792 heme-binding site [chemical binding]; other site 386585005793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585005794 metal binding site [ion binding]; metal-binding site 386585005795 active site 386585005796 I-site; other site 386585005797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 386585005798 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 386585005799 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 386585005800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585005801 catalytic residue [active] 386585005802 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 386585005803 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 386585005804 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 386585005805 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 386585005806 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 386585005807 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 386585005808 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 386585005809 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 386585005810 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 386585005811 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 386585005812 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 386585005813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585005814 FeS/SAM binding site; other site 386585005815 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 386585005816 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 386585005817 Sulfatase; Region: Sulfatase; pfam00884 386585005818 transcriptional regulator YdeO; Provisional; Region: PRK09940 386585005819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585005820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585005821 putative oxidoreductase; Provisional; Region: PRK09939 386585005822 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 386585005823 putative molybdopterin cofactor binding site [chemical binding]; other site 386585005824 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 386585005825 putative molybdopterin cofactor binding site; other site 386585005826 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 386585005827 mannosyl binding site [chemical binding]; other site 386585005828 Fimbrial protein; Region: Fimbrial; cl01416 386585005829 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585005830 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585005831 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 386585005832 Outer membrane usher protein; Region: Usher; pfam00577 386585005833 PapC C-terminal domain; Region: PapC_C; pfam13953 386585005834 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 386585005835 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585005836 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585005837 Fimbrial protein; Region: Fimbrial; cl01416 386585005838 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 386585005839 HipA-like C-terminal domain; Region: HipA_C; pfam07804 386585005840 beta subunit of N-acylethanolamine-hydrolyzing acid amidase; Region: NAAA-beta; pfam15508 386585005841 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585005842 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 386585005843 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585005844 putative lipoprotein; Provisional; Region: PRK09707 386585005845 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 386585005846 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 386585005847 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 386585005848 putative N- and C-terminal domain interface [polypeptide binding]; other site 386585005849 putative active site [active] 386585005850 putative MgATP binding site [chemical binding]; other site 386585005851 catalytic site [active] 386585005852 metal binding site [ion binding]; metal-binding site 386585005853 putative carbohydrate binding site [chemical binding]; other site 386585005854 transcriptional regulator LsrR; Provisional; Region: PRK15418 386585005855 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 386585005856 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 386585005857 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 386585005858 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585005859 Walker A/P-loop; other site 386585005860 ATP binding site [chemical binding]; other site 386585005861 Q-loop/lid; other site 386585005862 ABC transporter signature motif; other site 386585005863 Walker B; other site 386585005864 D-loop; other site 386585005865 H-loop/switch region; other site 386585005866 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585005867 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585005868 TM-ABC transporter signature motif; other site 386585005869 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585005870 TM-ABC transporter signature motif; other site 386585005871 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 386585005872 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 386585005873 ligand binding site [chemical binding]; other site 386585005874 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 386585005875 putative active site; other site 386585005876 catalytic residue [active] 386585005877 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 386585005878 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 386585005879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585005880 S-adenosylmethionine binding site [chemical binding]; other site 386585005881 Predicted membrane protein [Function unknown]; Region: COG3781 386585005882 altronate oxidoreductase; Provisional; Region: PRK03643 386585005883 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 386585005884 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 386585005885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585005886 metal binding site [ion binding]; metal-binding site 386585005887 active site 386585005888 I-site; other site 386585005889 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 386585005890 glutaminase; Provisional; Region: PRK00971 386585005891 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 386585005892 NAD(P) binding site [chemical binding]; other site 386585005893 catalytic residues [active] 386585005894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585005895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585005896 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 386585005897 putative dimerization interface [polypeptide binding]; other site 386585005898 putative arabinose transporter; Provisional; Region: PRK03545 386585005899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585005900 putative substrate translocation pore; other site 386585005901 inner membrane protein; Provisional; Region: PRK10995 386585005902 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 386585005903 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585005904 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 386585005905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585005906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585005907 MarB protein; Region: MarB; pfam13999 386585005908 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 386585005909 EamA-like transporter family; Region: EamA; pfam00892 386585005910 EamA-like transporter family; Region: EamA; pfam00892 386585005911 putative transporter; Provisional; Region: PRK10054 386585005912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585005913 putative substrate translocation pore; other site 386585005914 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 386585005915 active site residue [active] 386585005916 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 386585005917 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 386585005918 conserved cys residue [active] 386585005919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585005920 diguanylate cyclase; Provisional; Region: PRK09894 386585005921 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 386585005922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585005923 metal binding site [ion binding]; metal-binding site 386585005924 active site 386585005925 I-site; other site 386585005926 hypothetical protein; Provisional; Region: PRK10053 386585005927 hypothetical protein; Validated; Region: PRK03657 386585005928 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 386585005929 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 386585005930 active site 386585005931 Zn binding site [ion binding]; other site 386585005932 malonic semialdehyde reductase; Provisional; Region: PRK10538 386585005933 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 386585005934 putative NAD(P) binding site [chemical binding]; other site 386585005935 homodimer interface [polypeptide binding]; other site 386585005936 homotetramer interface [polypeptide binding]; other site 386585005937 active site 386585005938 Transcriptional regulators [Transcription]; Region: GntR; COG1802 386585005939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585005940 DNA-binding site [nucleotide binding]; DNA binding site 386585005941 FCD domain; Region: FCD; pfam07729 386585005942 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 386585005943 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 386585005944 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 386585005945 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 386585005946 metabolite-proton symporter; Region: 2A0106; TIGR00883 386585005947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585005948 putative substrate translocation pore; other site 386585005949 DinI-like family; Region: DinI; pfam06183 386585005950 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585005951 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585005952 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585005953 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585005954 similar to tail fiber protein; disrupted by frameshift 386585005955 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585005956 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585005957 Phage-related protein, tail component [Function unknown]; Region: COG4733 386585005958 Putative phage tail protein; Region: Phage-tail_3; pfam13550 386585005959 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 386585005960 Interdomain contacts; other site 386585005961 Cytokine receptor motif; other site 386585005962 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 386585005963 Fibronectin type III protein; Region: DUF3672; pfam12421 386585005964 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585005965 Predicted metal-dependent protease of the PAD1/JAB1 superfamily [General function prediction only]; Region: COG1310 386585005966 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585005967 NlpC/P60 family; Region: NLPC_P60; cl17555 386585005968 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585005969 MPN+ (JAMM) motif; other site 386585005970 Zinc-binding site [ion binding]; other site 386585005971 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585005972 Phage-related protein [Function unknown]; Region: COG4718 386585005973 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585005974 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 386585005975 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585005976 Minor tail protein T; Region: Phage_tail_T; cl05636 386585005977 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 386585005978 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 386585005979 Phage tail protein; Region: Phage_tail_3; pfam08813 386585005980 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 386585005981 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 386585005982 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 386585005983 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 386585005984 DNA packaging protein FI; Region: Packaging_FI; pfam14000 386585005985 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 386585005986 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 386585005987 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 386585005988 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 386585005989 tandem repeat interface [polypeptide binding]; other site 386585005990 oligomer interface [polypeptide binding]; other site 386585005991 active site residues [active] 386585005992 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 386585005993 gpW; Region: gpW; pfam02831 386585005994 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 386585005995 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 386585005996 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 386585005997 PerC transcriptional activator; Region: PerC; pfam06069 386585005998 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585005999 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585006000 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585006001 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585006002 catalytic residues [active] 386585006003 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585006004 Lysis protein S; Region: Lysis_S; pfam04971 386585006005 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585006006 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585006007 tellurite resistance protein terB; Region: terB; cd07176 386585006008 putative metal binding site [ion binding]; other site 386585006009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585006010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585006011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585006012 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 386585006013 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 386585006014 Protein of unknown function (DUF968); Region: DUF968; pfam06147 386585006015 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 386585006016 Hok/gef family; Region: HOK_GEF; pfam01848 386585006017 Protein of unknown function (DUF551); Region: DUF551; pfam04448 386585006018 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 386585006019 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 386585006020 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 386585006021 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 386585006022 primosomal protein DnaI; Provisional; Region: PRK02854 386585006023 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585006024 DNA-binding transcriptional regulator Cro; Region: P22_Cro; pfam14549 386585006025 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 386585006026 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585006027 Catalytic site [active] 386585006028 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 386585006029 DicB protein; Region: DicB; pfam05358 386585006030 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 386585006031 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 386585006032 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 386585006033 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585006034 DNA binding site [nucleotide binding] 386585006035 Int/Topo IB signature motif; other site 386585006036 active site 386585006037 DinI-like family; Region: DinI; pfam06183 386585006038 putative transposase OrfB; Reviewed; Region: PHA02517 386585006039 HTH-like domain; Region: HTH_21; pfam13276 386585006040 Integrase core domain; Region: rve; pfam00665 386585006041 Integrase core domain; Region: rve_3; pfam13683 386585006042 Transposase; Region: HTH_Tnp_1; cl17663 386585006043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585006044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 386585006045 Transposase, Mutator family; Region: Transposase_mut; cl19537 386585006046 Transposase; Region: HTH_Tnp_1; pfam01527 386585006047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585006048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585006049 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585006050 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585006051 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585006052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585006053 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585006054 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585006055 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585006056 similar to transposase; disrupted by frameshift 386585006057 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585006058 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585006059 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585006060 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585006061 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585006062 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585006063 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585006064 similar to host specificity protein; disrupted by frameshift 386585006065 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585006066 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585006067 MPN+ (JAMM) motif; other site 386585006068 Zinc-binding site [ion binding]; other site 386585006069 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585006070 NlpC/P60 family; Region: NLPC_P60; cl17555 386585006071 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585006072 Phage-related protein [Function unknown]; Region: COG4718 386585006073 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585006074 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585006075 tape measure domain; Region: tape_meas_nterm; TIGR02675 386585006076 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585006077 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 386585006078 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 386585006079 Immunoglobulin I-set domain; Region: I-set; pfam07679 386585006080 Immunoglobulin domain; Region: Ig_2; pfam13895 386585006081 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 386585006082 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 386585006083 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 386585006084 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 386585006085 oligomerization interface [polypeptide binding]; other site 386585006086 Phage-related protein [Function unknown]; Region: COG4695 386585006087 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 386585006088 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 386585006089 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 386585006090 Phage capsid family; Region: Phage_capsid; pfam05065 386585006091 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 386585006092 Phage Terminase; Region: Terminase_1; cl19862 386585006093 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 386585006094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585006095 active site 386585006096 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 386585006097 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585006098 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585006099 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585006100 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585006101 catalytic residues [active] 386585006102 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585006103 Lysis protein S; Region: Lysis_S; pfam04971 386585006104 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585006105 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585006106 tellurite resistance protein terB; Region: terB; cd07176 386585006107 putative metal binding site [ion binding]; other site 386585006108 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 386585006109 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 386585006110 Protein of unknown function (DUF968); Region: DUF968; pfam06147 386585006111 Hok/gef family; Region: HOK_GEF; pfam01848 386585006112 Protein of unknown function (DUF551); Region: DUF551; pfam04448 386585006113 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 386585006114 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 386585006115 putative replication protein; Provisional; Region: PRK12377 386585006116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585006117 Walker A motif; other site 386585006118 ATP binding site [chemical binding]; other site 386585006119 Walker B motif; other site 386585006120 Helix-turn-helix domain; Region: HTH_36; pfam13730 386585006121 primosomal protein DnaI; Provisional; Region: PRK02854 386585006122 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585006123 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 386585006124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585006125 non-specific DNA binding site [nucleotide binding]; other site 386585006126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585006127 salt bridge; other site 386585006128 sequence-specific DNA binding site [nucleotide binding]; other site 386585006129 transcriptional repressor DicA; Reviewed; Region: PRK09706 386585006130 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 386585006131 phosphoinositide binding site [chemical binding]; other site 386585006132 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 386585006133 DicB protein; Region: DicB; pfam05358 386585006134 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 386585006135 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 386585006136 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 386585006137 active site 386585006138 catalytic site [active] 386585006139 substrate binding site [chemical binding]; other site 386585006140 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 386585006141 hypothetical protein; Provisional; Region: PRK02237 386585006142 hypothetical protein; Provisional; Region: PRK13659 386585006143 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 386585006144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585006145 Coenzyme A binding pocket [chemical binding]; other site 386585006146 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 386585006147 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 386585006148 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 386585006149 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 386585006150 putative [Fe4-S4] binding site [ion binding]; other site 386585006151 putative molybdopterin cofactor binding site [chemical binding]; other site 386585006152 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 386585006153 putative molybdopterin cofactor binding site; other site 386585006154 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 386585006155 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 386585006156 putative [Fe4-S4] binding site [ion binding]; other site 386585006157 putative molybdopterin cofactor binding site [chemical binding]; other site 386585006158 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 386585006159 putative molybdopterin cofactor binding site; other site 386585006160 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 386585006161 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585006162 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 386585006163 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 386585006164 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 386585006165 Cl- selectivity filter; other site 386585006166 Cl- binding residues [ion binding]; other site 386585006167 pore gating glutamate residue; other site 386585006168 dimer interface [polypeptide binding]; other site 386585006169 putative dithiobiotin synthetase; Provisional; Region: PRK12374 386585006170 AAA domain; Region: AAA_26; pfam13500 386585006171 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 386585006172 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 386585006173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585006174 nucleotide binding site [chemical binding]; other site 386585006175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 386585006176 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 386585006177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585006178 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 386585006179 dimerization interface [polypeptide binding]; other site 386585006180 substrate binding pocket [chemical binding]; other site 386585006181 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 386585006182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006183 putative substrate translocation pore; other site 386585006184 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 386585006185 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 386585006186 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 386585006187 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 386585006188 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 386585006189 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 386585006190 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 386585006191 ligand binding site [chemical binding]; other site 386585006192 homodimer interface [polypeptide binding]; other site 386585006193 NAD(P) binding site [chemical binding]; other site 386585006194 trimer interface B [polypeptide binding]; other site 386585006195 trimer interface A [polypeptide binding]; other site 386585006196 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 386585006197 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585006198 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585006199 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585006200 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 386585006201 Spore germination protein; Region: Spore_permease; cl17796 386585006202 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 386585006203 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 386585006204 NADP binding site [chemical binding]; other site 386585006205 substrate binding pocket [chemical binding]; other site 386585006206 active site 386585006207 GlpM protein; Region: GlpM; pfam06942 386585006208 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 386585006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585006210 active site 386585006211 phosphorylation site [posttranslational modification] 386585006212 intermolecular recognition site; other site 386585006213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585006214 DNA binding site [nucleotide binding] 386585006215 sensor protein RstB; Provisional; Region: PRK10604 386585006216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585006217 dimerization interface [polypeptide binding]; other site 386585006218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585006219 dimer interface [polypeptide binding]; other site 386585006220 phosphorylation site [posttranslational modification] 386585006221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585006222 ATP binding site [chemical binding]; other site 386585006223 Mg2+ binding site [ion binding]; other site 386585006224 G-X-G motif; other site 386585006225 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 386585006226 fumarate hydratase; Reviewed; Region: fumC; PRK00485 386585006227 Class II fumarases; Region: Fumarase_classII; cd01362 386585006228 active site 386585006229 tetramer interface [polypeptide binding]; other site 386585006230 fumarate hydratase; Provisional; Region: PRK15389 386585006231 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 386585006232 Fumarase C-terminus; Region: Fumerase_C; pfam05683 386585006233 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 386585006234 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 386585006235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 386585006236 similar to UidC; disrupted by frameshift 386585006237 glucuronide transporter; Provisional; Region: PRK09848 386585006238 putative symporter YagG; Provisional; Region: PRK09669; cl15392 386585006239 similar to beta-D-glucuronidase; disrupted by frameshift 386585006240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 386585006241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585006242 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 386585006243 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 386585006244 NAD binding site [chemical binding]; other site 386585006245 substrate binding site [chemical binding]; other site 386585006246 homotetramer interface [polypeptide binding]; other site 386585006247 homodimer interface [polypeptide binding]; other site 386585006248 active site 386585006249 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 386585006250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585006251 DNA binding site [nucleotide binding] 386585006252 domain linker motif; other site 386585006253 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 386585006254 putative dimerization interface [polypeptide binding]; other site 386585006255 putative ligand binding site [chemical binding]; other site 386585006256 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 386585006257 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 386585006258 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585006259 active site turn [active] 386585006260 phosphorylation site [posttranslational modification] 386585006261 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 386585006262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585006263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585006264 homodimer interface [polypeptide binding]; other site 386585006265 catalytic residue [active] 386585006266 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 386585006267 active site 386585006268 purine riboside binding site [chemical binding]; other site 386585006269 putative oxidoreductase; Provisional; Region: PRK11579 386585006270 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 386585006271 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 386585006272 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 386585006273 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 386585006274 electron transport complex protein RsxA; Provisional; Region: PRK05151 386585006275 electron transport complex protein RnfB; Provisional; Region: PRK05113 386585006276 Putative Fe-S cluster; Region: FeS; pfam04060 386585006277 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585006278 electron transport complex protein RnfC; Provisional; Region: PRK05035 386585006279 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 386585006280 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 386585006281 SLBB domain; Region: SLBB; pfam10531 386585006282 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 386585006283 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 386585006284 electron transport complex protein RnfG; Validated; Region: PRK01908 386585006285 electron transport complex RsxE subunit; Provisional; Region: PRK12405 386585006286 endonuclease III; Provisional; Region: PRK10702 386585006287 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 386585006288 minor groove reading motif; other site 386585006289 helix-hairpin-helix signature motif; other site 386585006290 substrate binding pocket [chemical binding]; other site 386585006291 active site 386585006292 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 386585006293 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 386585006294 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 386585006295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006296 putative substrate translocation pore; other site 386585006297 glutathionine S-transferase; Provisional; Region: PRK10542 386585006298 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 386585006299 C-terminal domain interface [polypeptide binding]; other site 386585006300 GSH binding site (G-site) [chemical binding]; other site 386585006301 dimer interface [polypeptide binding]; other site 386585006302 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 386585006303 N-terminal domain interface [polypeptide binding]; other site 386585006304 dimer interface [polypeptide binding]; other site 386585006305 substrate binding pocket (H-site) [chemical binding]; other site 386585006306 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 386585006307 dimer interface [polypeptide binding]; other site 386585006308 pyridoxal binding site [chemical binding]; other site 386585006309 ATP binding site [chemical binding]; other site 386585006310 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 386585006311 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 386585006312 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 386585006313 active site 386585006314 HIGH motif; other site 386585006315 dimer interface [polypeptide binding]; other site 386585006316 KMSKS motif; other site 386585006317 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585006318 RNA binding surface [nucleotide binding]; other site 386585006319 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 386585006320 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 386585006321 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 386585006322 lysozyme inhibitor; Provisional; Region: PRK11372 386585006323 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 386585006324 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 386585006325 transcriptional regulator SlyA; Provisional; Region: PRK03573 386585006326 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585006327 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 386585006328 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 386585006329 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585006330 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585006331 Fusaric acid resistance protein family; Region: FUSC; pfam04632 386585006332 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 386585006333 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 386585006334 E-class dimer interface [polypeptide binding]; other site 386585006335 P-class dimer interface [polypeptide binding]; other site 386585006336 active site 386585006337 Cu2+ binding site [ion binding]; other site 386585006338 Zn2+ binding site [ion binding]; other site 386585006339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585006340 active site 386585006341 catalytic tetrad [active] 386585006342 Predicted Fe-S protein [General function prediction only]; Region: COG3313 386585006343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 386585006344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585006345 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 386585006346 FMN binding site [chemical binding]; other site 386585006347 active site 386585006348 substrate binding site [chemical binding]; other site 386585006349 catalytic residue [active] 386585006350 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 386585006351 dimer interface [polypeptide binding]; other site 386585006352 active site 386585006353 metal binding site [ion binding]; metal-binding site 386585006354 glutathione binding site [chemical binding]; other site 386585006355 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 386585006356 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 386585006357 dimer interface [polypeptide binding]; other site 386585006358 catalytic site [active] 386585006359 putative active site [active] 386585006360 putative substrate binding site [chemical binding]; other site 386585006361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585006362 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 386585006363 ATP binding site [chemical binding]; other site 386585006364 putative Mg++ binding site [ion binding]; other site 386585006365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585006366 nucleotide binding region [chemical binding]; other site 386585006367 ATP-binding site [chemical binding]; other site 386585006368 DEAD/H associated; Region: DEAD_assoc; pfam08494 386585006369 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 386585006370 putative GSH binding site [chemical binding]; other site 386585006371 catalytic residues [active] 386585006372 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585006373 NlpC/P60 family; Region: NLPC_P60; pfam00877 386585006374 superoxide dismutase; Provisional; Region: PRK10543 386585006375 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 386585006376 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 386585006377 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 386585006378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006379 putative substrate translocation pore; other site 386585006380 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 386585006381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585006382 DNA binding site [nucleotide binding] 386585006383 domain linker motif; other site 386585006384 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 386585006385 dimerization interface [polypeptide binding]; other site 386585006386 ligand binding site [chemical binding]; other site 386585006387 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 386585006388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585006389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585006390 dimerization interface [polypeptide binding]; other site 386585006391 putative transporter; Provisional; Region: PRK11043 386585006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006393 putative substrate translocation pore; other site 386585006394 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 386585006395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 386585006396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585006397 S-adenosylmethionine binding site [chemical binding]; other site 386585006398 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 386585006399 Lumazine binding domain; Region: Lum_binding; pfam00677 386585006400 Lumazine binding domain; Region: Lum_binding; pfam00677 386585006401 multidrug efflux protein; Reviewed; Region: PRK01766 386585006402 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 386585006403 cation binding site [ion binding]; other site 386585006404 hypothetical protein; Provisional; Region: PRK09945 386585006405 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 386585006406 putative monooxygenase; Provisional; Region: PRK11118 386585006407 hypothetical protein; Provisional; Region: PRK09897 386585006408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 386585006409 hypothetical protein; Provisional; Region: PRK09946 386585006410 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 386585006411 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 386585006412 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 386585006413 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585006414 hypothetical protein; Provisional; Region: PRK09947 386585006415 putative oxidoreductase; Provisional; Region: PRK09849 386585006416 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 386585006417 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 386585006418 hypothetical protein; Provisional; Region: PRK09898 386585006419 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585006420 hypothetical protein; Provisional; Region: PRK10292 386585006421 pyruvate kinase; Provisional; Region: PRK09206 386585006422 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 386585006423 domain interfaces; other site 386585006424 active site 386585006425 murein lipoprotein; Provisional; Region: PRK15396 386585006426 L,D-transpeptidase; Provisional; Region: PRK10260 386585006427 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585006428 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 386585006429 cysteine desufuration protein SufE; Provisional; Region: PRK09296 386585006430 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 386585006431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585006432 catalytic residue [active] 386585006433 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 386585006434 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 386585006435 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 386585006436 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 386585006437 Walker A/P-loop; other site 386585006438 ATP binding site [chemical binding]; other site 386585006439 Q-loop/lid; other site 386585006440 ABC transporter signature motif; other site 386585006441 Walker B; other site 386585006442 D-loop; other site 386585006443 H-loop/switch region; other site 386585006444 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 386585006445 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 386585006446 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 386585006447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 386585006448 CoenzymeA binding site [chemical binding]; other site 386585006449 subunit interaction site [polypeptide binding]; other site 386585006450 PHB binding site; other site 386585006451 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 386585006452 FAD binding domain; Region: FAD_binding_4; pfam01565 386585006453 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 386585006454 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 386585006455 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 386585006456 putative inner membrane protein; Provisional; Region: PRK10983 386585006457 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 386585006458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585006460 putative substrate translocation pore; other site 386585006461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585006463 putative substrate translocation pore; other site 386585006464 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 386585006465 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 386585006466 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 386585006467 shikimate binding site; other site 386585006468 NAD(P) binding site [chemical binding]; other site 386585006469 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 386585006470 active site 386585006471 catalytic residue [active] 386585006472 dimer interface [polypeptide binding]; other site 386585006473 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 386585006474 Coenzyme A transferase; Region: CoA_trans; smart00882 386585006475 Coenzyme A transferase; Region: CoA_trans; cl17247 386585006476 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 386585006477 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 386585006478 active site 386585006479 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 386585006480 Cupin domain; Region: Cupin_2; pfam07883 386585006481 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 386585006482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585006483 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 386585006484 Ligand binding site [chemical binding]; other site 386585006485 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 386585006486 Electron transfer flavoprotein domain; Region: ETF; pfam01012 386585006487 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 386585006488 oxidoreductase; Provisional; Region: PRK10015 386585006489 putative oxidoreductase FixC; Provisional; Region: PRK10157 386585006490 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 386585006491 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 386585006492 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 386585006493 acyl-activating enzyme (AAE) consensus motif; other site 386585006494 putative AMP binding site [chemical binding]; other site 386585006495 putative active site [active] 386585006496 putative CoA binding site [chemical binding]; other site 386585006497 phosphoenolpyruvate synthase; Validated; Region: PRK06464 386585006498 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 386585006499 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 386585006500 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 386585006501 PEP synthetase regulatory protein; Provisional; Region: PRK05339 386585006502 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 386585006503 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 386585006504 hypothetical protein; Validated; Region: PRK00029 386585006505 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 386585006506 NlpC/P60 family; Region: NLPC_P60; pfam00877 386585006507 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 386585006508 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 386585006509 Walker A/P-loop; other site 386585006510 ATP binding site [chemical binding]; other site 386585006511 Q-loop/lid; other site 386585006512 ABC transporter signature motif; other site 386585006513 Walker B; other site 386585006514 D-loop; other site 386585006515 H-loop/switch region; other site 386585006516 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 386585006517 catalytic residues [active] 386585006518 dimer interface [polypeptide binding]; other site 386585006519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585006520 ABC-ATPase subunit interface; other site 386585006521 dimer interface [polypeptide binding]; other site 386585006522 putative PBP binding regions; other site 386585006523 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 386585006524 DNA binding site [nucleotide binding] 386585006525 dimer interface [polypeptide binding]; other site 386585006526 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 386585006527 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 386585006528 putative tRNA-binding site [nucleotide binding]; other site 386585006529 B3/4 domain; Region: B3_4; pfam03483 386585006530 tRNA synthetase B5 domain; Region: B5; smart00874 386585006531 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 386585006532 dimer interface [polypeptide binding]; other site 386585006533 motif 1; other site 386585006534 motif 3; other site 386585006535 motif 2; other site 386585006536 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 386585006537 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 386585006538 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 386585006539 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 386585006540 dimer interface [polypeptide binding]; other site 386585006541 motif 1; other site 386585006542 active site 386585006543 motif 2; other site 386585006544 motif 3; other site 386585006545 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 386585006546 23S rRNA binding site [nucleotide binding]; other site 386585006547 L21 binding site [polypeptide binding]; other site 386585006548 L13 binding site [polypeptide binding]; other site 386585006549 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 386585006550 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 386585006551 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 386585006552 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 386585006553 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 386585006554 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 386585006555 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 386585006556 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 386585006557 active site 386585006558 dimer interface [polypeptide binding]; other site 386585006559 motif 1; other site 386585006560 motif 2; other site 386585006561 motif 3; other site 386585006562 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 386585006563 anticodon binding site; other site 386585006564 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 386585006565 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 386585006566 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 386585006567 putative substrate binding site [chemical binding]; other site 386585006568 putative ATP binding site [chemical binding]; other site 386585006569 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 386585006570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 386585006571 Phosphotransferase enzyme family; Region: APH; pfam01636 386585006572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 386585006573 active site 386585006574 substrate binding site [chemical binding]; other site 386585006575 ATP binding site [chemical binding]; other site 386585006576 YniB-like protein; Region: YniB; pfam14002 386585006577 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 386585006578 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 386585006579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585006580 motif II; other site 386585006581 inner membrane protein; Provisional; Region: PRK11648 386585006582 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 386585006583 Cell division activator CedA; Region: CedA; pfam10729 386585006584 hydroperoxidase II; Provisional; Region: katE; PRK11249 386585006585 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 386585006586 tetramer interface [polypeptide binding]; other site 386585006587 heme binding pocket [chemical binding]; other site 386585006588 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 386585006589 domain interactions; other site 386585006590 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 386585006591 putative active site [active] 386585006592 YdjC motif; other site 386585006593 Mg binding site [ion binding]; other site 386585006594 putative homodimer interface [polypeptide binding]; other site 386585006595 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 386585006596 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 386585006597 NAD binding site [chemical binding]; other site 386585006598 sugar binding site [chemical binding]; other site 386585006599 divalent metal binding site [ion binding]; other site 386585006600 tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585006601 dimer interface [polypeptide binding]; other site 386585006602 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 386585006603 Cupin domain; Region: Cupin_2; cl17218 386585006604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585006605 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 386585006606 methionine cluster; other site 386585006607 active site 386585006608 phosphorylation site [posttranslational modification] 386585006609 metal binding site [ion binding]; metal-binding site 386585006610 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 386585006611 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 386585006612 active site 386585006613 P-loop; other site 386585006614 phosphorylation site [posttranslational modification] 386585006615 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 386585006616 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 386585006617 homodimer interface [polypeptide binding]; other site 386585006618 NAD binding pocket [chemical binding]; other site 386585006619 ATP binding pocket [chemical binding]; other site 386585006620 Mg binding site [ion binding]; other site 386585006621 active-site loop [active] 386585006622 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 386585006623 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 386585006624 GIY-YIG motif/motif A; other site 386585006625 active site 386585006626 catalytic site [active] 386585006627 putative DNA binding site [nucleotide binding]; other site 386585006628 metal binding site [ion binding]; metal-binding site 386585006629 hypothetical protein; Provisional; Region: PRK11396 386585006630 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 386585006631 dimer interface [polypeptide binding]; other site 386585006632 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 386585006633 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 386585006634 putative active site [active] 386585006635 Zn binding site [ion binding]; other site 386585006636 succinylarginine dihydrolase; Provisional; Region: PRK13281 386585006637 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 386585006638 NAD(P) binding site [chemical binding]; other site 386585006639 catalytic residues [active] 386585006640 arginine succinyltransferase; Provisional; Region: PRK10456 386585006641 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 386585006642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585006643 inhibitor-cofactor binding pocket; inhibition site 386585006644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585006645 catalytic residue [active] 386585006646 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 386585006647 putative catalytic site [active] 386585006648 putative phosphate binding site [ion binding]; other site 386585006649 active site 386585006650 metal binding site A [ion binding]; metal-binding site 386585006651 DNA binding site [nucleotide binding] 386585006652 putative AP binding site [nucleotide binding]; other site 386585006653 putative metal binding site B [ion binding]; other site 386585006654 Uncharacterized conserved protein [Function unknown]; Region: COG0398 386585006655 Uncharacterized conserved protein [Function unknown]; Region: COG0398 386585006656 Uncharacterized conserved protein [Function unknown]; Region: COG2128 386585006657 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 386585006658 hypothetical protein; Provisional; Region: PRK11622 386585006659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 386585006660 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 386585006661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585006662 putative PBP binding loops; other site 386585006663 ABC-ATPase subunit interface; other site 386585006664 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 386585006665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585006666 Walker A/P-loop; other site 386585006667 ATP binding site [chemical binding]; other site 386585006668 Q-loop/lid; other site 386585006669 ABC transporter signature motif; other site 386585006670 Walker B; other site 386585006671 D-loop; other site 386585006672 H-loop/switch region; other site 386585006673 Rhodanese Homology Domain; Region: RHOD; smart00450 386585006674 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 386585006675 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 386585006676 active site residue [active] 386585006677 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 386585006678 active site residue [active] 386585006679 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 386585006680 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 386585006681 active site 386585006682 8-oxo-dGMP binding site [chemical binding]; other site 386585006683 nudix motif; other site 386585006684 metal binding site [ion binding]; metal-binding site 386585006685 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 386585006686 glutamate dehydrogenase; Provisional; Region: PRK09414 386585006687 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 386585006688 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 386585006689 NAD(P) binding site [chemical binding]; other site 386585006690 hypothetical protein; Provisional; Region: PRK11380 386585006691 DNA topoisomerase III; Provisional; Region: PRK07726 386585006692 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 386585006693 active site 386585006694 putative interdomain interaction site [polypeptide binding]; other site 386585006695 putative metal-binding site [ion binding]; other site 386585006696 putative nucleotide binding site [chemical binding]; other site 386585006697 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 386585006698 domain I; other site 386585006699 DNA binding groove [nucleotide binding] 386585006700 phosphate binding site [ion binding]; other site 386585006701 domain II; other site 386585006702 domain III; other site 386585006703 nucleotide binding site [chemical binding]; other site 386585006704 catalytic site [active] 386585006705 domain IV; other site 386585006706 selenophosphate synthetase; Provisional; Region: PRK00943 386585006707 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 386585006708 dimerization interface [polypeptide binding]; other site 386585006709 putative ATP binding site [chemical binding]; other site 386585006710 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 386585006711 putative FMN binding site [chemical binding]; other site 386585006712 protease 4; Provisional; Region: PRK10949 386585006713 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 386585006714 tandem repeat interface [polypeptide binding]; other site 386585006715 oligomer interface [polypeptide binding]; other site 386585006716 active site residues [active] 386585006717 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 386585006718 tandem repeat interface [polypeptide binding]; other site 386585006719 oligomer interface [polypeptide binding]; other site 386585006720 active site residues [active] 386585006721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 386585006722 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 386585006723 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 386585006724 active site 386585006725 homodimer interface [polypeptide binding]; other site 386585006726 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 386585006727 catalytic triad [active] 386585006728 metal binding site [ion binding]; metal-binding site 386585006729 conserved cis-peptide bond; other site 386585006730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006731 D-galactonate transporter; Region: 2A0114; TIGR00893 386585006732 putative substrate translocation pore; other site 386585006733 Transposase; Region: HTH_Tnp_1; cl17663 386585006734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585006735 putative transposase OrfB; Reviewed; Region: PHA02517 386585006736 HTH-like domain; Region: HTH_21; pfam13276 386585006737 Integrase core domain; Region: rve; pfam00665 386585006738 Integrase core domain; Region: rve_3; pfam13683 386585006739 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 386585006740 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 386585006741 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585006742 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585006743 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585006744 active site 386585006745 catalytic tetrad [active] 386585006746 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 386585006747 substrate binding site [chemical binding]; other site 386585006748 ATP binding site [chemical binding]; other site 386585006749 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 386585006750 intersubunit interface [polypeptide binding]; other site 386585006751 active site 386585006752 zinc binding site [ion binding]; other site 386585006753 Na+ binding site [ion binding]; other site 386585006754 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585006755 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 386585006756 inhibitor binding site; inhibition site 386585006757 catalytic Zn binding site [ion binding]; other site 386585006758 structural Zn binding site [ion binding]; other site 386585006759 NADP binding site [chemical binding]; other site 386585006760 tetramer interface [polypeptide binding]; other site 386585006761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006762 putative substrate translocation pore; other site 386585006763 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 386585006764 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585006765 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 386585006766 putative NAD(P) binding site [chemical binding]; other site 386585006767 catalytic Zn binding site [ion binding]; other site 386585006768 structural Zn binding site [ion binding]; other site 386585006769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 386585006770 methionine sulfoxide reductase B; Provisional; Region: PRK00222 386585006771 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 386585006772 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 386585006773 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 386585006774 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 386585006775 active site 386585006776 phosphate binding residues; other site 386585006777 catalytic residues [active] 386585006778 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585006779 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585006780 active site 386585006781 catalytic tetrad [active] 386585006782 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 386585006783 PrkA family serine protein kinase; Provisional; Region: PRK15455 386585006784 PrkA AAA domain; Region: AAA_PrkA; pfam08298 386585006785 Walker A motif; other site 386585006786 ATP binding site [chemical binding]; other site 386585006787 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 386585006788 Uncharacterized conserved protein [Function unknown]; Region: COG2718 386585006789 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 386585006790 metal ion-dependent adhesion site (MIDAS); other site 386585006791 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585006792 metal binding site [ion binding]; metal-binding site 386585006793 active site 386585006794 I-site; other site 386585006795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585006796 metal binding site [ion binding]; metal-binding site 386585006797 active site 386585006798 I-site; other site 386585006799 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 386585006800 putative deacylase active site [active] 386585006801 Predicted membrane protein [Function unknown]; Region: COG2707 386585006802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585006803 cyanate transporter; Region: CynX; TIGR00896 386585006804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006805 putative substrate translocation pore; other site 386585006806 Uncharacterized conserved protein [Function unknown]; Region: COG3189 386585006807 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 386585006808 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 386585006809 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585006810 metal binding site [ion binding]; metal-binding site 386585006811 active site 386585006812 I-site; other site 386585006813 hypothetical protein; Provisional; Region: PRK10457 386585006814 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 386585006815 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 386585006816 leucine export protein LeuE; Provisional; Region: PRK10958 386585006817 transcriptional activator TtdR; Provisional; Region: PRK09801 386585006818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585006819 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 386585006820 putative effector binding pocket; other site 386585006821 putative dimerization interface [polypeptide binding]; other site 386585006822 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 386585006823 putative transporter; Provisional; Region: PRK09950 386585006824 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 386585006825 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 386585006826 [2Fe-2S] cluster binding site [ion binding]; other site 386585006827 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 386585006828 putative alpha subunit interface [polypeptide binding]; other site 386585006829 putative active site [active] 386585006830 putative substrate binding site [chemical binding]; other site 386585006831 Fe binding site [ion binding]; other site 386585006832 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 386585006833 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 386585006834 FMN-binding pocket [chemical binding]; other site 386585006835 flavin binding motif; other site 386585006836 phosphate binding motif [ion binding]; other site 386585006837 beta-alpha-beta structure motif; other site 386585006838 NAD binding pocket [chemical binding]; other site 386585006839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585006840 catalytic loop [active] 386585006841 iron binding site [ion binding]; other site 386585006842 ribonuclease D; Provisional; Region: PRK10829 386585006843 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 386585006844 catalytic site [active] 386585006845 putative active site [active] 386585006846 putative substrate binding site [chemical binding]; other site 386585006847 Helicase and RNase D C-terminal; Region: HRDC; smart00341 386585006848 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 386585006849 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 386585006850 acyl-activating enzyme (AAE) consensus motif; other site 386585006851 putative AMP binding site [chemical binding]; other site 386585006852 putative active site [active] 386585006853 putative CoA binding site [chemical binding]; other site 386585006854 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 386585006855 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 386585006856 Glycoprotease family; Region: Peptidase_M22; pfam00814 386585006857 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 386585006858 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 386585006859 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 386585006860 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 386585006861 homotrimer interaction site [polypeptide binding]; other site 386585006862 putative active site [active] 386585006863 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 386585006864 hypothetical protein; Provisional; Region: PRK05114 386585006865 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 386585006866 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 386585006867 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 386585006868 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 386585006869 putative active site [active] 386585006870 putative CoA binding site [chemical binding]; other site 386585006871 nudix motif; other site 386585006872 L-serine deaminase; Provisional; Region: PRK15023 386585006873 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 386585006874 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 386585006875 phage resistance protein; Provisional; Region: PRK10551 386585006876 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 386585006877 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585006878 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 386585006879 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 386585006880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 386585006881 Transporter associated domain; Region: CorC_HlyC; smart01091 386585006882 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 386585006883 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 386585006884 active pocket/dimerization site; other site 386585006885 active site 386585006886 phosphorylation site [posttranslational modification] 386585006887 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 386585006888 active site 386585006889 phosphorylation site [posttranslational modification] 386585006890 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 386585006891 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 386585006892 hypothetical protein; Provisional; Region: PRK02913 386585006893 hypothetical protein; Provisional; Region: PRK11469 386585006894 Domain of unknown function DUF; Region: DUF204; pfam02659 386585006895 Domain of unknown function DUF; Region: DUF204; pfam02659 386585006896 Methyltransferase domain; Region: Methyltransf_31; pfam13847 386585006897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585006898 S-adenosylmethionine binding site [chemical binding]; other site 386585006899 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 386585006900 DNA-binding site [nucleotide binding]; DNA binding site 386585006901 RNA-binding motif; other site 386585006902 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 386585006903 YebO-like protein; Region: YebO; pfam13974 386585006904 PhoPQ regulatory protein; Provisional; Region: PRK10299 386585006905 YobH-like protein; Region: YobH; pfam13996 386585006906 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 386585006907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585006908 dimerization interface [polypeptide binding]; other site 386585006909 putative Zn2+ binding site [ion binding]; other site 386585006910 putative DNA binding site [nucleotide binding]; other site 386585006911 Bacterial transcriptional regulator; Region: IclR; pfam01614 386585006912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585006913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585006914 putative substrate translocation pore; other site 386585006915 Predicted integral membrane protein [Function unknown]; Region: COG5521 386585006916 heat shock protein HtpX; Provisional; Region: PRK05457 386585006917 carboxy-terminal protease; Provisional; Region: PRK11186 386585006918 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 386585006919 protein binding site [polypeptide binding]; other site 386585006920 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 386585006921 Catalytic dyad [active] 386585006922 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 386585006923 ProP expression regulator; Provisional; Region: PRK04950 386585006924 putative RNA binding sites [nucleotide binding]; other site 386585006925 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 386585006926 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 386585006927 Paraquat-inducible protein A; Region: PqiA; pfam04403 386585006928 Paraquat-inducible protein A; Region: PqiA; pfam04403 386585006929 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 386585006930 mce related protein; Region: MCE; pfam02470 386585006931 mce related protein; Region: MCE; pfam02470 386585006932 mce related protein; Region: MCE; pfam02470 386585006933 mce related protein; Region: MCE; pfam02470 386585006934 mce related protein; Region: MCE; pfam02470 386585006935 mce related protein; Region: MCE; pfam02470 386585006936 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 386585006937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585006938 S-adenosylmethionine binding site [chemical binding]; other site 386585006939 Uncharacterized conserved protein [Function unknown]; Region: COG3270 386585006940 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 386585006941 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 386585006942 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 386585006943 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 386585006944 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 386585006945 hypothetical protein; Provisional; Region: PRK10301 386585006946 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 386585006947 Predicted amidohydrolase [General function prediction only]; Region: COG0388 386585006948 exodeoxyribonuclease X; Provisional; Region: PRK07983 386585006949 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 386585006950 active site 386585006951 catalytic site [active] 386585006952 substrate binding site [chemical binding]; other site 386585006953 protease 2; Provisional; Region: PRK10115 386585006954 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 386585006955 Protein of unknown function (DUF533); Region: DUF533; pfam04391 386585006956 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 386585006957 putative metal binding site [ion binding]; other site 386585006958 hypothetical protein; Provisional; Region: PRK13680 386585006959 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 386585006960 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 386585006961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585006962 ATP-grasp domain; Region: ATP-grasp; pfam02222 386585006963 Entner-Doudoroff aldolase; Region: eda; TIGR01182 386585006964 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 386585006965 active site 386585006966 intersubunit interface [polypeptide binding]; other site 386585006967 catalytic residue [active] 386585006968 phosphogluconate dehydratase; Validated; Region: PRK09054 386585006969 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 386585006970 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 386585006971 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 386585006972 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 386585006973 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 386585006974 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 386585006975 putative active site [active] 386585006976 pyruvate kinase; Provisional; Region: PRK05826 386585006977 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 386585006978 domain interfaces; other site 386585006979 active site 386585006980 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 386585006981 putative acyl-acceptor binding pocket; other site 386585006982 putative peptidase; Provisional; Region: PRK11649 386585006983 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 386585006984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585006985 Peptidase family M23; Region: Peptidase_M23; pfam01551 386585006986 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 386585006987 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 386585006988 metal binding site [ion binding]; metal-binding site 386585006989 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 386585006990 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 386585006991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585006992 ABC-ATPase subunit interface; other site 386585006993 dimer interface [polypeptide binding]; other site 386585006994 putative PBP binding regions; other site 386585006995 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 386585006996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585006997 Walker A motif; other site 386585006998 ATP binding site [chemical binding]; other site 386585006999 Walker B motif; other site 386585007000 arginine finger; other site 386585007001 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 386585007002 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 386585007003 RuvA N terminal domain; Region: RuvA_N; pfam01330 386585007004 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 386585007005 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 386585007006 hypothetical protein; Provisional; Region: PRK11470 386585007007 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 386585007008 active site 386585007009 putative DNA-binding cleft [nucleotide binding]; other site 386585007010 dimer interface [polypeptide binding]; other site 386585007011 hypothetical protein; Validated; Region: PRK00110 386585007012 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 386585007013 nudix motif; other site 386585007014 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 386585007015 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 386585007016 dimer interface [polypeptide binding]; other site 386585007017 anticodon binding site; other site 386585007018 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 386585007019 homodimer interface [polypeptide binding]; other site 386585007020 motif 1; other site 386585007021 active site 386585007022 motif 2; other site 386585007023 GAD domain; Region: GAD; pfam02938 386585007024 motif 3; other site 386585007025 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 386585007026 catalytic triad [active] 386585007027 conserved cis-peptide bond; other site 386585007028 hypothetical protein; Provisional; Region: PRK10302 386585007029 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 386585007030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585007031 S-adenosylmethionine binding site [chemical binding]; other site 386585007032 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 386585007033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585007034 S-adenosylmethionine binding site [chemical binding]; other site 386585007035 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 386585007036 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 386585007037 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 386585007038 molybdopterin cofactor binding site [chemical binding]; other site 386585007039 substrate binding site [chemical binding]; other site 386585007040 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 386585007041 molybdopterin cofactor binding site; other site 386585007042 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 386585007043 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 386585007044 copper homeostasis protein CutC; Provisional; Region: PRK11572 386585007045 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 386585007046 putative metal binding site [ion binding]; other site 386585007047 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 386585007048 arginyl-tRNA synthetase; Region: argS; TIGR00456 386585007049 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 386585007050 active site 386585007051 HIGH motif; other site 386585007052 KMSK motif region; other site 386585007053 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 386585007054 tRNA binding surface [nucleotide binding]; other site 386585007055 anticodon binding site; other site 386585007056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 386585007057 Flagellar protein FlhE; Region: FlhE; pfam06366 386585007058 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 386585007059 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 386585007060 chemotaxis regulator CheZ; Provisional; Region: PRK11166 386585007061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585007062 active site 386585007063 phosphorylation site [posttranslational modification] 386585007064 intermolecular recognition site; other site 386585007065 dimerization interface [polypeptide binding]; other site 386585007066 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 386585007067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585007068 active site 386585007069 phosphorylation site [posttranslational modification] 386585007070 intermolecular recognition site; other site 386585007071 dimerization interface [polypeptide binding]; other site 386585007072 CheB methylesterase; Region: CheB_methylest; pfam01339 386585007073 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 386585007074 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 386585007075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585007076 S-adenosylmethionine binding site [chemical binding]; other site 386585007077 methyl-accepting protein IV; Provisional; Region: PRK09793 386585007078 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 386585007079 dimer interface [polypeptide binding]; other site 386585007080 ligand binding site [chemical binding]; other site 386585007081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585007082 dimerization interface [polypeptide binding]; other site 386585007083 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 386585007084 dimer interface [polypeptide binding]; other site 386585007085 putative CheW interface [polypeptide binding]; other site 386585007086 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 386585007087 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 386585007088 dimer interface [polypeptide binding]; other site 386585007089 ligand binding site [chemical binding]; other site 386585007090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585007091 dimerization interface [polypeptide binding]; other site 386585007092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 386585007093 dimer interface [polypeptide binding]; other site 386585007094 putative CheW interface [polypeptide binding]; other site 386585007095 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 386585007096 putative CheA interaction surface; other site 386585007097 chemotaxis protein CheA; Provisional; Region: PRK10547 386585007098 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 386585007099 putative binding surface; other site 386585007100 active site 386585007101 CheY binding; Region: CheY-binding; pfam09078 386585007102 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 386585007103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585007104 ATP binding site [chemical binding]; other site 386585007105 Mg2+ binding site [ion binding]; other site 386585007106 G-X-G motif; other site 386585007107 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 386585007108 flagellar motor protein MotB; Validated; Region: motB; PRK09041 386585007109 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 386585007110 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585007111 ligand binding site [chemical binding]; other site 386585007112 flagellar motor protein MotA; Validated; Region: PRK09110 386585007113 transcriptional activator FlhC; Provisional; Region: PRK12722 386585007114 transcriptional activator FlhD; Provisional; Region: PRK02909 386585007115 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585007116 Ligand Binding Site [chemical binding]; other site 386585007117 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 386585007118 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 386585007119 active site 386585007120 homotetramer interface [polypeptide binding]; other site 386585007121 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 386585007122 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 386585007123 similar to high-affinity L-arabinose transport protein; disrupted by frameshift 386585007124 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 386585007125 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585007126 Walker A/P-loop; other site 386585007127 ATP binding site [chemical binding]; other site 386585007128 Q-loop/lid; other site 386585007129 ABC transporter signature motif; other site 386585007130 Walker B; other site 386585007131 D-loop; other site 386585007132 H-loop/switch region; other site 386585007133 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585007134 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 386585007135 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 386585007136 ligand binding site [chemical binding]; other site 386585007137 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 386585007138 Ferritin-like domain; Region: Ferritin; pfam00210 386585007139 ferroxidase diiron center [ion binding]; other site 386585007140 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 386585007141 YecR-like lipoprotein; Region: YecR; pfam13992 386585007142 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 386585007143 Ferritin-like domain; Region: Ferritin; pfam00210 386585007144 ferroxidase diiron center [ion binding]; other site 386585007145 probable metal-binding protein; Region: matur_matur; TIGR03853 386585007146 tyrosine transporter TyrP; Provisional; Region: PRK15132 386585007147 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585007148 hypothetical protein; Provisional; Region: PRK10396 386585007149 yecA family protein; Region: ygfB_yecA; TIGR02292 386585007150 SEC-C motif; Region: SEC-C; cl19389 386585007151 integrase; Provisional; Region: int; PHA02601 386585007152 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 386585007153 dimer interface [polypeptide binding]; other site 386585007154 active site 386585007155 catalytic residues [active] 386585007156 Int/Topo IB signature motif; other site 386585007157 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 386585007158 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 386585007159 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585007160 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 386585007161 putative DNA binding site [nucleotide binding]; other site 386585007162 putative Zn2+ binding site [ion binding]; other site 386585007163 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 386585007164 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 386585007165 Mg binding site [ion binding]; other site 386585007166 nucleotide binding site [chemical binding]; other site 386585007167 putative protofilament interface [polypeptide binding]; other site 386585007168 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 386585007169 HTH-like domain; Region: HTH_21; pfam13276 386585007170 Integrase core domain; Region: rve; pfam00665 386585007171 Transposase; Region: HTH_Tnp_1; cl17663 386585007172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585007173 similar to tail fiber assembly proteins e.g. Orf194 [Bacteriophage lambda gi|139990|sp|P03740|Y194_LAMBD 386585007174 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 386585007175 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 386585007176 putative trimer interface [polypeptide binding]; other site 386585007177 putative CoA binding site [chemical binding]; other site 386585007178 Phage protein U [General function prediction only]; Region: COG3499 386585007179 similar to tail protein; disrupted by frameshift 386585007180 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 386585007181 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 386585007182 Phage tail tube protein FII [General function prediction only]; Region: COG3498 386585007183 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 386585007184 Phage protein D [General function prediction only]; Region: COG3500 386585007185 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 386585007186 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 386585007187 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 386585007188 GIY-YIG motif/motif A; other site 386585007189 active site 386585007190 catalytic site [active] 386585007191 putative DNA binding site [nucleotide binding]; other site 386585007192 metal binding site [ion binding]; metal-binding site 386585007193 UvrB/uvrC motif; Region: UVR; pfam02151 386585007194 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 386585007195 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 386585007196 response regulator; Provisional; Region: PRK09483 386585007197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585007198 active site 386585007199 phosphorylation site [posttranslational modification] 386585007200 intermolecular recognition site; other site 386585007201 dimerization interface [polypeptide binding]; other site 386585007202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585007203 DNA binding residues [nucleotide binding] 386585007204 dimerization interface [polypeptide binding]; other site 386585007205 hypothetical protein; Provisional; Region: PRK10613 386585007206 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 386585007207 Autoinducer binding domain; Region: Autoind_bind; pfam03472 386585007208 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585007209 DNA binding residues [nucleotide binding] 386585007210 dimerization interface [polypeptide binding]; other site 386585007211 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 386585007212 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 386585007213 Walker A/P-loop; other site 386585007214 ATP binding site [chemical binding]; other site 386585007215 Q-loop/lid; other site 386585007216 ABC transporter signature motif; other site 386585007217 Walker B; other site 386585007218 D-loop; other site 386585007219 H-loop/switch region; other site 386585007220 amino acid ABC transporter permease; Provisional; Region: PRK15100 386585007221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585007222 dimer interface [polypeptide binding]; other site 386585007223 conserved gate region; other site 386585007224 putative PBP binding loops; other site 386585007225 ABC-ATPase subunit interface; other site 386585007226 similar to 1-aminocyclopropane-1-carboxylate deaminase; disrupted by frameshift 386585007227 cystine transporter subunit; Provisional; Region: PRK11260 386585007228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585007229 substrate binding pocket [chemical binding]; other site 386585007230 membrane-bound complex binding site; other site 386585007231 hinge residues; other site 386585007232 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 386585007233 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 386585007234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 386585007235 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 386585007236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 386585007237 DNA binding residues [nucleotide binding] 386585007238 flagellin; Validated; Region: PRK08026 386585007239 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 386585007240 Flagellin protein; Region: FliC; pfam12445 386585007241 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 386585007242 flagellar capping protein; Reviewed; Region: fliD; PRK08032 386585007243 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 386585007244 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 386585007245 Flagellar protein FliS; Region: FliS; cl00654 386585007246 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 386585007247 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 386585007248 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 386585007249 active site 386585007250 Na/Ca binding site [ion binding]; other site 386585007251 catalytic site [active] 386585007252 lipoprotein; Provisional; Region: PRK10397 386585007253 putative inner membrane protein; Provisional; Region: PRK11099 386585007254 Predicted transporter component [General function prediction only]; Region: COG2391 386585007255 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 386585007256 CPxP motif; other site 386585007257 hypothetical protein; Provisional; Region: PRK09951 386585007258 similar to Escherichia coli YedL; disrupted by frameshift 386585007259 similar to Escherichia coli YedM; disrupted by frameshift 386585007260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 386585007261 flagellar hook-basal body complex protein FliE; Region: fliE; TIGR00205 386585007262 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 386585007263 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 386585007264 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 386585007265 flagellar motor switch protein FliG; Region: fliG; TIGR00207 386585007266 FliG N-terminal domain; Region: FliG_N; pfam14842 386585007267 FliG middle domain; Region: FliG_M; pfam14841 386585007268 FliG C-terminal domain; Region: FliG_C; pfam01706 386585007269 flagellar assembly protein H; Validated; Region: fliH; PRK05687 386585007270 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 386585007271 Flagellar assembly protein FliH; Region: FliH; pfam02108 386585007272 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 386585007273 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 386585007274 Walker A motif/ATP binding site; other site 386585007275 Walker B motif; other site 386585007276 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 386585007277 flagellar hook-length control protein; Provisional; Region: PRK10118 386585007278 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 386585007279 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 386585007280 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 386585007281 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 386585007282 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 386585007283 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 386585007284 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 386585007285 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 386585007286 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 386585007287 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 386585007288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585007289 DNA binding residues [nucleotide binding] 386585007290 dimerization interface [polypeptide binding]; other site 386585007291 hypothetical protein; Provisional; Region: PRK10708 386585007292 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 386585007293 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 386585007294 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 386585007295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585007296 active site 386585007297 motif I; other site 386585007298 motif II; other site 386585007299 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 386585007300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585007301 metal binding site [ion binding]; metal-binding site 386585007302 active site 386585007303 I-site; other site 386585007304 Uncharacterized small protein [Function unknown]; Region: COG5475 386585007305 hypothetical protein; Provisional; Region: PRK10062 386585007306 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 386585007307 EamA-like transporter family; Region: EamA; pfam00892 386585007308 EamA-like transporter family; Region: EamA; pfam00892 386585007309 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 386585007310 additional DNA contacts [nucleotide binding]; other site 386585007311 mismatch recognition site; other site 386585007312 active site 386585007313 zinc binding site [ion binding]; other site 386585007314 DNA intercalation site [nucleotide binding]; other site 386585007315 DNA cytosine methylase; Provisional; Region: PRK10458 386585007316 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 386585007317 cofactor binding site; other site 386585007318 DNA binding site [nucleotide binding] 386585007319 substrate interaction site [chemical binding]; other site 386585007320 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 386585007321 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 386585007322 Zn2+ binding site [ion binding]; other site 386585007323 Mg2+ binding site [ion binding]; other site 386585007324 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 386585007325 trimer interface [polypeptide binding]; other site 386585007326 eyelet of channel; other site 386585007327 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 386585007328 chaperone protein HchA; Provisional; Region: PRK04155 386585007329 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 386585007330 conserved cys residue [active] 386585007331 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 386585007332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585007333 dimer interface [polypeptide binding]; other site 386585007334 phosphorylation site [posttranslational modification] 386585007335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585007336 ATP binding site [chemical binding]; other site 386585007337 Mg2+ binding site [ion binding]; other site 386585007338 G-X-G motif; other site 386585007339 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 386585007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585007341 active site 386585007342 phosphorylation site [posttranslational modification] 386585007343 intermolecular recognition site; other site 386585007344 dimerization interface [polypeptide binding]; other site 386585007345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585007346 DNA binding site [nucleotide binding] 386585007347 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 386585007348 active site 386585007349 homotetramer interface [polypeptide binding]; other site 386585007350 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 386585007351 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 386585007352 Moco binding site; other site 386585007353 metal coordination site [ion binding]; other site 386585007354 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 386585007355 zinc/cadmium-binding protein; Provisional; Region: PRK10306 386585007356 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 386585007357 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 386585007358 EspF protein repeat; Region: EspF; pfam04806 386585007359 EspF protein repeat; Region: EspF; pfam04806 386585007360 EspF protein repeat; Region: EspF; pfam04806 386585007361 EspF protein repeat; Region: EspF; pfam04806 386585007362 EspF protein repeat; Region: EspF; pfam04806 386585007363 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585007364 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585007365 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585007366 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585007367 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585007368 similar to host specificity protein; disrupted by frameshift 386585007369 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585007370 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 386585007371 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585007372 NlpC/P60 family; Region: NLPC_P60; cl17555 386585007373 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585007374 Phage-related protein [Function unknown]; Region: COG4718 386585007375 similar to tail length tape measure protein precursor; disrupted by frameshift 386585007376 Minor tail protein T; Region: Phage_tail_T; cl05636 386585007377 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 386585007378 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 386585007379 Phage tail protein; Region: Phage_tail_3; pfam08813 386585007380 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 386585007381 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 386585007382 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 386585007383 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 386585007384 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 386585007385 tandem repeat interface [polypeptide binding]; other site 386585007386 oligomer interface [polypeptide binding]; other site 386585007387 active site residues [active] 386585007388 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 386585007389 gpW; Region: gpW; pfam02831 386585007390 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 386585007391 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 386585007392 PerC transcriptional activator; Region: PerC; pfam06069 386585007393 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585007394 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585007395 catalytic residues [active] 386585007396 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585007397 Lysis protein S; Region: Lysis_S; pfam04971 386585007398 Transposase; Region: HTH_Tnp_1; cl17663 386585007399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585007400 putative transposase OrfB; Reviewed; Region: PHA02517 386585007401 HTH-like domain; Region: HTH_21; pfam13276 386585007402 Integrase core domain; Region: rve; pfam00665 386585007403 Integrase core domain; Region: rve_3; pfam13683 386585007404 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585007405 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585007406 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 386585007407 tellurite resistance protein terB; Region: terB; cd07176 386585007408 putative metal binding site [ion binding]; other site 386585007409 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 386585007410 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 386585007411 Protein of unknown function (DUF968); Region: DUF968; pfam06147 386585007412 Hok/gef family; Region: HOK_GEF; pfam01848 386585007413 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 386585007414 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 386585007415 primosomal protein DnaI; Provisional; Region: PRK02854 386585007416 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 386585007417 DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770 386585007418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585007419 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 386585007420 non-specific DNA binding site [nucleotide binding]; other site 386585007421 salt bridge; other site 386585007422 sequence-specific DNA binding site [nucleotide binding]; other site 386585007423 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585007424 Catalytic site [active] 386585007425 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 386585007426 DicB protein; Region: DicB; pfam05358 386585007427 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 386585007428 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 386585007429 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 386585007430 active site 386585007431 substrate binding site [chemical binding]; other site 386585007432 catalytic site [active] 386585007433 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 386585007434 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585007435 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 386585007436 dimer interface [polypeptide binding]; other site 386585007437 active site 386585007438 Int/Topo IB signature motif; other site 386585007439 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 386585007440 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 386585007441 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007442 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007443 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 386585007444 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007445 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007446 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007447 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007448 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007449 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007450 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 386585007451 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007452 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 386585007453 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 386585007454 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007455 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007456 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585007457 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 386585007458 shikimate transporter; Provisional; Region: PRK09952 386585007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585007460 putative substrate translocation pore; other site 386585007461 AMP nucleosidase; Provisional; Region: PRK08292 386585007462 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 386585007463 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 386585007464 hypothetical protein; Provisional; Region: PRK12378 386585007465 similar to E. coli YeeO; disrupted by frameshift 386585007466 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 386585007467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585007468 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 386585007469 putative substrate binding site [chemical binding]; other site 386585007470 dimerization interface [polypeptide binding]; other site 386585007471 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 386585007472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585007473 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 386585007474 putative dimerization interface [polypeptide binding]; other site 386585007475 L,D-transpeptidase; Provisional; Region: PRK10190 386585007476 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 386585007477 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 386585007478 putative dimer interface [polypeptide binding]; other site 386585007479 active site pocket [active] 386585007480 putative cataytic base [active] 386585007481 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 386585007482 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 386585007483 homotrimer interface [polypeptide binding]; other site 386585007484 Walker A motif; other site 386585007485 GTP binding site [chemical binding]; other site 386585007486 Walker B motif; other site 386585007487 Transposase; Region: HTH_Tnp_1; pfam01527 386585007488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585007489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585007490 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585007491 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585007492 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585007493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585007494 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585007495 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585007496 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585007497 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 386585007498 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585007499 N-terminal plug; other site 386585007500 ligand-binding site [chemical binding]; other site 386585007501 Transposase; Region: HTH_Tnp_1; cl17663 386585007502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585007503 putative transposase OrfB; Reviewed; Region: PHA02517 386585007504 HTH-like domain; Region: HTH_21; pfam13276 386585007505 Integrase core domain; Region: rve; pfam00665 386585007506 Integrase core domain; Region: rve_3; pfam13683 386585007507 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 386585007508 YjcZ-like protein; Region: YjcZ; pfam13990 386585007509 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 386585007510 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 386585007511 active site 386585007512 nucleophile elbow; other site 386585007513 Domain of unknown function (DUF932); Region: DUF932; pfam06067 386585007514 Antirestriction protein; Region: Antirestrict; pfam03230 386585007515 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 386585007516 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 386585007517 MPN+ (JAMM) motif; other site 386585007518 Zinc-binding site [ion binding]; other site 386585007519 Protein of unknown function (DUF987); Region: DUF987; pfam06174 386585007520 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 386585007521 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 386585007522 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 386585007523 Switch II region; other site 386585007524 G4 box; other site 386585007525 G5 box; other site 386585007526 hypothetical protein; Provisional; Region: PRK05423 386585007527 Predicted membrane protein [Function unknown]; Region: COG1289 386585007528 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 386585007529 DNA gyrase inhibitor; Provisional; Region: PRK10016 386585007530 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 386585007531 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 386585007532 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 386585007533 exonuclease I; Provisional; Region: sbcB; PRK11779 386585007534 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 386585007535 active site 386585007536 catalytic site [active] 386585007537 substrate binding site [chemical binding]; other site 386585007538 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 386585007539 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 386585007540 CPxP motif; other site 386585007541 Predicted transporter component [General function prediction only]; Region: COG2391 386585007542 Sulphur transport; Region: Sulf_transp; cl19477 386585007543 Sulphur transport; Region: Sulf_transp; cl19477 386585007544 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 386585007545 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585007546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585007547 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 386585007548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585007549 dimerization interface [polypeptide binding]; other site 386585007550 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 386585007551 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 386585007552 putative NAD(P) binding site [chemical binding]; other site 386585007553 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 386585007554 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 386585007555 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 386585007556 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 386585007557 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 386585007558 NAD binding site [chemical binding]; other site 386585007559 dimerization interface [polypeptide binding]; other site 386585007560 product binding site; other site 386585007561 substrate binding site [chemical binding]; other site 386585007562 zinc binding site [ion binding]; other site 386585007563 catalytic residues [active] 386585007564 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 386585007565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585007566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585007567 homodimer interface [polypeptide binding]; other site 386585007568 catalytic residue [active] 386585007569 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 386585007570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585007571 active site 386585007572 motif I; other site 386585007573 motif II; other site 386585007574 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 386585007575 putative active site pocket [active] 386585007576 4-fold oligomerization interface [polypeptide binding]; other site 386585007577 metal binding residues [ion binding]; metal-binding site 386585007578 3-fold/trimer interface [polypeptide binding]; other site 386585007579 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 386585007580 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 386585007581 putative active site [active] 386585007582 oxyanion strand; other site 386585007583 catalytic triad [active] 386585007584 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 386585007585 catalytic residues [active] 386585007586 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 386585007587 substrate binding site [chemical binding]; other site 386585007588 glutamase interaction surface [polypeptide binding]; other site 386585007589 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 386585007590 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 386585007591 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 386585007592 metal binding site [ion binding]; metal-binding site 386585007593 chain length determinant protein WzzB; Provisional; Region: PRK15471 386585007594 Chain length determinant protein; Region: Wzz; pfam02706 386585007595 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 386585007596 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 386585007597 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 386585007598 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 386585007599 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 386585007600 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 386585007601 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 386585007602 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 386585007603 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 386585007604 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 386585007605 putative trimer interface [polypeptide binding]; other site 386585007606 putative CoA binding site [chemical binding]; other site 386585007607 Transposase [DNA replication, recombination, and repair]; Region: COG5433 386585007608 phosphomannomutase CpsG; Provisional; Region: PRK15414 386585007609 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 386585007610 active site 386585007611 substrate binding site [chemical binding]; other site 386585007612 metal binding site [ion binding]; metal-binding site 386585007613 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 386585007614 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 386585007615 Substrate binding site; other site 386585007616 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 386585007617 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 386585007618 active site 386585007619 GDP-Mannose binding site [chemical binding]; other site 386585007620 dimer interface [polypeptide binding]; other site 386585007621 modified nudix motif 386585007622 metal binding site [ion binding]; metal-binding site 386585007623 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 386585007624 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 386585007625 NADP binding site [chemical binding]; other site 386585007626 active site 386585007627 putative substrate binding site [chemical binding]; other site 386585007628 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 386585007629 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 386585007630 NADP-binding site; other site 386585007631 homotetramer interface [polypeptide binding]; other site 386585007632 substrate binding site [chemical binding]; other site 386585007633 homodimer interface [polypeptide binding]; other site 386585007634 active site 386585007635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 386585007636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 386585007637 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 386585007638 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 386585007639 inhibitor-cofactor binding pocket; inhibition site 386585007640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585007641 catalytic residue [active] 386585007642 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 386585007643 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 386585007644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 386585007645 active site 386585007646 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 386585007647 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 386585007648 active site 386585007649 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 386585007650 active site 386585007651 tetramer interface; other site 386585007652 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 386585007653 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 386585007654 putative NAD(P) binding site [chemical binding]; other site 386585007655 active site 386585007656 putative substrate binding site [chemical binding]; other site 386585007657 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 386585007658 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 386585007659 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 386585007660 putative ADP-binding pocket [chemical binding]; other site 386585007661 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 386585007662 colanic acid exporter; Provisional; Region: PRK10459 386585007663 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 386585007664 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 386585007665 CoA-binding domain; Region: CoA_binding_3; pfam13727 386585007666 Bacterial sugar transferase; Region: Bac_transf; pfam02397 386585007667 phosphomannomutase CpsG; Provisional; Region: PRK15414 386585007668 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 386585007669 active site 386585007670 substrate binding site [chemical binding]; other site 386585007671 metal binding site [ion binding]; metal-binding site 386585007672 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 386585007673 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 386585007674 Substrate binding site; other site 386585007675 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 386585007676 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 386585007677 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 386585007678 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 386585007679 active site 386585007680 GDP-Mannose binding site [chemical binding]; other site 386585007681 dimer interface [polypeptide binding]; other site 386585007682 modified nudix motif 386585007683 metal binding site [ion binding]; metal-binding site 386585007684 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 386585007685 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 386585007686 NADP binding site [chemical binding]; other site 386585007687 active site 386585007688 putative substrate binding site [chemical binding]; other site 386585007689 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 386585007690 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 386585007691 NADP-binding site; other site 386585007692 homotetramer interface [polypeptide binding]; other site 386585007693 substrate binding site [chemical binding]; other site 386585007694 homodimer interface [polypeptide binding]; other site 386585007695 active site 386585007696 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 386585007697 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 386585007698 putative trimer interface [polypeptide binding]; other site 386585007699 putative active site [active] 386585007700 putative substrate binding site [chemical binding]; other site 386585007701 putative CoA binding site [chemical binding]; other site 386585007702 putative glycosyl transferase; Provisional; Region: PRK10063 386585007703 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 386585007704 metal-binding site 386585007705 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 386585007706 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 386585007707 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 386585007708 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 386585007709 putative acyl transferase; Provisional; Region: PRK10191 386585007710 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 386585007711 trimer interface [polypeptide binding]; other site 386585007712 active site 386585007713 substrate binding site [chemical binding]; other site 386585007714 CoA binding site [chemical binding]; other site 386585007715 putative glycosyl transferase; Provisional; Region: PRK10018 386585007716 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 386585007717 active site 386585007718 tyrosine kinase; Provisional; Region: PRK11519 386585007719 Chain length determinant protein; Region: Wzz; pfam02706 386585007720 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 386585007721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585007722 Low molecular weight phosphatase family; Region: LMWPc; cd00115 386585007723 active site 386585007724 polysaccharide export protein Wza; Provisional; Region: PRK15078 386585007725 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 386585007726 SLBB domain; Region: SLBB; pfam10531 386585007727 SLBB domain; Region: SLBB; pfam10531 386585007728 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 386585007729 FOG: CBS domain [General function prediction only]; Region: COG0517 386585007730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 386585007731 Transporter associated domain; Region: CorC_HlyC; smart01091 386585007732 Phage-related protein [Function unknown]; Region: COG4679 386585007733 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585007734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585007735 non-specific DNA binding site [nucleotide binding]; other site 386585007736 salt bridge; other site 386585007737 sequence-specific DNA binding site [nucleotide binding]; other site 386585007738 putative assembly protein; Provisional; Region: PRK10833 386585007739 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 386585007740 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 386585007741 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 386585007742 trimer interface [polypeptide binding]; other site 386585007743 active site 386585007744 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 386585007745 ATP-binding site [chemical binding]; other site 386585007746 Sugar specificity; other site 386585007747 Pyrimidine base specificity; other site 386585007748 similar to sensor-type protein YegE; disrupted by frameshift 386585007749 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 386585007750 AlkA N-terminal domain; Region: AlkA_N; smart01009 386585007751 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 386585007752 minor groove reading motif; other site 386585007753 helix-hairpin-helix signature motif; other site 386585007754 substrate binding pocket [chemical binding]; other site 386585007755 active site 386585007756 putative chaperone; Provisional; Region: PRK11678 386585007757 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 386585007758 nucleotide binding site [chemical binding]; other site 386585007759 putative NEF/HSP70 interaction site [polypeptide binding]; other site 386585007760 SBD interface [polypeptide binding]; other site 386585007761 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 386585007762 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 386585007763 Protein phosphatase 2C; Region: PP2C_2; pfam13672 386585007764 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 386585007765 metal ion-dependent adhesion site (MIDAS); other site 386585007766 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 386585007767 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585007768 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585007769 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 386585007770 MMPL family; Region: MMPL; cl14618 386585007771 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 386585007772 MMPL family; Region: MMPL; cl14618 386585007773 MMPL family; Region: MMPL; cl14618 386585007774 putative transporter; Provisional; Region: PRK10504 386585007775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585007776 putative substrate translocation pore; other site 386585007777 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 386585007778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585007779 dimerization interface [polypeptide binding]; other site 386585007780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585007781 dimer interface [polypeptide binding]; other site 386585007782 phosphorylation site [posttranslational modification] 386585007783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585007784 ATP binding site [chemical binding]; other site 386585007785 Mg2+ binding site [ion binding]; other site 386585007786 G-X-G motif; other site 386585007787 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 386585007788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585007789 active site 386585007790 phosphorylation site [posttranslational modification] 386585007791 intermolecular recognition site; other site 386585007792 dimerization interface [polypeptide binding]; other site 386585007793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585007794 DNA binding site [nucleotide binding] 386585007795 Uncharacterized conserved protein [Function unknown]; Region: COG3422 386585007796 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 386585007797 putative protease; Provisional; Region: PRK15452 386585007798 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 386585007799 lipid kinase; Reviewed; Region: PRK13054 386585007800 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 386585007801 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 386585007802 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 386585007803 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585007804 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 386585007805 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 386585007806 putative NAD(P) binding site [chemical binding]; other site 386585007807 catalytic Zn binding site [ion binding]; other site 386585007808 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 386585007809 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 386585007810 active site 386585007811 P-loop; other site 386585007812 phosphorylation site [posttranslational modification] 386585007813 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585007814 active site 386585007815 phosphorylation site [posttranslational modification] 386585007816 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 386585007817 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 386585007818 intersubunit interface [polypeptide binding]; other site 386585007819 active site 386585007820 zinc binding site [ion binding]; other site 386585007821 Na+ binding site [ion binding]; other site 386585007822 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 386585007823 putative active site; other site 386585007824 catalytic residue [active] 386585007825 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 386585007826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585007827 putative substrate translocation pore; other site 386585007828 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 386585007829 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 386585007830 substrate binding site [chemical binding]; other site 386585007831 ATP binding site [chemical binding]; other site 386585007832 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 386585007833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585007834 DNA-binding site [nucleotide binding]; DNA binding site 386585007835 UTRA domain; Region: UTRA; pfam07702 386585007836 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 386585007837 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 386585007838 active site 386585007839 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 386585007840 dimer interface [polypeptide binding]; other site 386585007841 substrate binding site [chemical binding]; other site 386585007842 ATP binding site [chemical binding]; other site 386585007843 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 386585007844 substrate binding site [chemical binding]; other site 386585007845 multimerization interface [polypeptide binding]; other site 386585007846 ATP binding site [chemical binding]; other site 386585007847 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 386585007848 putative metal binding site [ion binding]; other site 386585007849 putative homodimer interface [polypeptide binding]; other site 386585007850 putative homotetramer interface [polypeptide binding]; other site 386585007851 putative homodimer-homodimer interface [polypeptide binding]; other site 386585007852 putative allosteric switch controlling residues; other site 386585007853 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 386585007854 Predicted integral membrane protein [Function unknown]; Region: COG5455 386585007855 Fimbrial protein; Region: Fimbrial; cl01416 386585007856 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 386585007857 PapC N-terminal domain; Region: PapC_N; pfam13954 386585007858 Outer membrane usher protein; Region: Usher; pfam00577 386585007859 PapC C-terminal domain; Region: PapC_C; pfam13953 386585007860 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 386585007861 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585007862 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585007863 Fimbrial protein; Region: Fimbrial; cl01416 386585007864 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 386585007865 antiporter inner membrane protein; Provisional; Region: PRK11670 386585007866 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 386585007867 Walker A motif; other site 386585007868 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 386585007869 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 386585007870 active site 386585007871 HIGH motif; other site 386585007872 KMSKS motif; other site 386585007873 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 386585007874 tRNA binding surface [nucleotide binding]; other site 386585007875 anticodon binding site; other site 386585007876 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 386585007877 dimer interface [polypeptide binding]; other site 386585007878 putative tRNA-binding site [nucleotide binding]; other site 386585007879 similar to molybdate metabolism regulator; disrupted by frameshift 386585007880 similar to molybdate metabolism regulator; disrupted by frameshift 386585007881 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 386585007882 MoxR-like ATPases [General function prediction only]; Region: COG0714 386585007883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585007884 Walker A motif; other site 386585007885 ATP binding site [chemical binding]; other site 386585007886 Walker B motif; other site 386585007887 arginine finger; other site 386585007888 similar to E. coli YehM; disrupted by frameshift 386585007889 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 386585007890 metal ion-dependent adhesion site (MIDAS); other site 386585007891 putative transposase OrfB; Reviewed; Region: PHA02517 386585007892 HTH-like domain; Region: HTH_21; pfam13276 386585007893 Integrase core domain; Region: rve; pfam00665 386585007894 Integrase core domain; Region: rve_3; pfam13683 386585007895 Transposase; Region: HTH_Tnp_1; cl17663 386585007896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585007897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 386585007898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 386585007899 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 386585007900 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 386585007901 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 386585007902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585007903 active site 386585007904 phosphorylation site [posttranslational modification] 386585007905 intermolecular recognition site; other site 386585007906 dimerization interface [polypeptide binding]; other site 386585007907 LytTr DNA-binding domain; Region: LytTR; pfam04397 386585007908 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 386585007909 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 386585007910 GAF domain; Region: GAF; pfam01590 386585007911 Histidine kinase; Region: His_kinase; pfam06580 386585007912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585007913 ATP binding site [chemical binding]; other site 386585007914 Mg2+ binding site [ion binding]; other site 386585007915 G-X-G motif; other site 386585007916 DinI-like family; Region: DinI; pfam06183 386585007917 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585007918 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 386585007919 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585007920 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 386585007921 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585007922 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585007923 similar to host specificity protein; disrupted by frameshift 386585007924 Phage-related protein, tail component [Function unknown]; Region: COG4723 386585007925 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 386585007926 MPN+ (JAMM) motif; other site 386585007927 Zinc-binding site [ion binding]; other site 386585007928 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 386585007929 NlpC/P60 family; Region: NLPC_P60; cl17555 386585007930 Phage-related protein [Function unknown]; Region: gp18; COG4672 386585007931 Phage-related protein [Function unknown]; Region: COG4718 386585007932 Phage-related minor tail protein [Function unknown]; Region: COG5281 386585007933 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 386585007934 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 386585007935 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 386585007936 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 386585007937 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 386585007938 Phage tail protein; Region: Phage_tail_3; pfam08813 386585007939 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 386585007940 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 386585007941 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 386585007942 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 386585007943 Uncharacterized conserved protein [Function unknown]; Region: COG5471 386585007944 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 386585007945 Transposase; Region: HTH_Tnp_1; cl17663 386585007946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585007947 putative transposase OrfB; Reviewed; Region: PHA02517 386585007948 HTH-like domain; Region: HTH_21; pfam13276 386585007949 Integrase core domain; Region: rve; pfam00665 386585007950 Integrase core domain; Region: rve_3; pfam13683 386585007951 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 386585007952 oligomer interface [polypeptide binding]; other site 386585007953 active site residues [active] 386585007954 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 386585007955 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 386585007956 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 386585007957 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 386585007958 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 386585007959 ORF11CD3 domain; Region: ORF11CD3; pfam10549 386585007960 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585007961 catalytic residues [active] 386585007962 Lysis protein S; Region: Lysis_S; pfam04971 386585007963 Protein of unknown function (DUF826); Region: DUF826; pfam05696 386585007964 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 386585007965 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585007966 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585007967 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 386585007968 Ribosome inactivating protein; Region: RIP; pfam00161 386585007969 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 386585007970 Phage NinH protein; Region: Phage_NinH; pfam06322 386585007971 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 386585007972 NinF protein; Region: NinF; pfam05810 386585007973 NINE Protein; Region: NinE; pfam05322 386585007974 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 386585007975 NinB protein; Region: NinB; pfam05772 386585007976 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 386585007977 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 386585007978 Replication protein P; Region: Phage_lambda_P; pfam06992 386585007979 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 386585007980 Bacteriophage CII protein; Region: Phage_CII; pfam05269 386585007981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585007982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585007983 non-specific DNA binding site [nucleotide binding]; other site 386585007984 salt bridge; other site 386585007985 sequence-specific DNA binding site [nucleotide binding]; other site 386585007986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585007987 non-specific DNA binding site [nucleotide binding]; other site 386585007988 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 386585007989 salt bridge; other site 386585007990 sequence-specific DNA binding site [nucleotide binding]; other site 386585007991 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585007992 Catalytic site [active] 386585007993 Superinfection exclusion protein B; Region: SieB; pfam14163 386585007994 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 386585007995 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 386585007996 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 386585007997 similar to host-nuclease inhibitor protein Gam; disrupted by frameshift 386585007998 phage recombination protein Bet; Region: bet_lambda; TIGR01913 386585007999 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 386585008000 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 386585008001 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 386585008002 DksA-like zinc finger domain containing protein; Region: PHA00080 386585008003 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 386585008004 Protein of unknown function (DUF551); Region: DUF551; pfam04448 386585008005 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 386585008006 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 386585008007 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 386585008008 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585008009 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 386585008010 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 386585008011 Int/Topo IB signature motif; other site 386585008012 transcriptional regulator MirA; Provisional; Region: PRK15043 386585008013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 386585008014 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 386585008015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 386585008016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585008017 dimer interface [polypeptide binding]; other site 386585008018 conserved gate region; other site 386585008019 putative PBP binding loops; other site 386585008020 ABC-ATPase subunit interface; other site 386585008021 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 386585008022 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 386585008023 Walker A/P-loop; other site 386585008024 ATP binding site [chemical binding]; other site 386585008025 Q-loop/lid; other site 386585008026 ABC transporter signature motif; other site 386585008027 Walker B; other site 386585008028 D-loop; other site 386585008029 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 386585008030 H-loop/switch region; other site 386585008031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585008032 dimer interface [polypeptide binding]; other site 386585008033 conserved gate region; other site 386585008034 putative PBP binding loops; other site 386585008035 ABC-ATPase subunit interface; other site 386585008036 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 386585008037 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 386585008038 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 386585008039 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 386585008040 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 386585008041 D-lactate dehydrogenase; Provisional; Region: PRK11183 386585008042 FAD binding domain; Region: FAD_binding_4; cl19922 386585008043 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 386585008044 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 386585008045 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 386585008046 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 386585008047 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 386585008048 oxidoreductase; Provisional; Region: PRK12743 386585008049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585008050 NAD(P) binding site [chemical binding]; other site 386585008051 active site 386585008052 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 386585008053 Outer membrane efflux protein; Region: OEP; pfam02321 386585008054 Outer membrane efflux protein; Region: OEP; pfam02321 386585008055 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 386585008056 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 386585008057 FMN binding site [chemical binding]; other site 386585008058 active site 386585008059 catalytic residues [active] 386585008060 substrate binding site [chemical binding]; other site 386585008061 salicylate hydroxylase; Provisional; Region: PRK08163 386585008062 Squalene epoxidase; Region: SE; cl17314 386585008063 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 386585008064 maleylacetoacetate isomerase; Region: maiA; TIGR01262 386585008065 C-terminal domain interface [polypeptide binding]; other site 386585008066 GSH binding site (G-site) [chemical binding]; other site 386585008067 putative dimer interface [polypeptide binding]; other site 386585008068 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 386585008069 dimer interface [polypeptide binding]; other site 386585008070 N-terminal domain interface [polypeptide binding]; other site 386585008071 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 386585008072 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 386585008073 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 386585008074 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 386585008075 Cupin domain; Region: Cupin_2; pfam07883 386585008076 Cupin domain; Region: Cupin_2; cl17218 386585008077 benzoate transport; Region: 2A0115; TIGR00895 386585008078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008079 putative substrate translocation pore; other site 386585008080 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 386585008081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585008082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585008083 dimerization interface [polypeptide binding]; other site 386585008084 hypothetical protein; Provisional; Region: PRK01821 386585008085 hypothetical protein; Provisional; Region: PRK10711 386585008086 cytidine deaminase; Provisional; Region: PRK09027 386585008087 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 386585008088 active site 386585008089 catalytic motif [active] 386585008090 Zn binding site [ion binding]; other site 386585008091 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 386585008092 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 386585008093 active site 386585008094 catalytic motif [active] 386585008095 Zn binding site [ion binding]; other site 386585008096 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 386585008097 putative active site [active] 386585008098 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 386585008099 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 386585008100 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 386585008101 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 386585008102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 386585008103 NAD binding site [chemical binding]; other site 386585008104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585008105 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 386585008106 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 386585008107 homodimer interface [polypeptide binding]; other site 386585008108 active site 386585008109 FMN binding site [chemical binding]; other site 386585008110 substrate binding site [chemical binding]; other site 386585008111 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585008112 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585008113 TM-ABC transporter signature motif; other site 386585008114 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585008115 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 386585008116 Walker A/P-loop; other site 386585008117 ATP binding site [chemical binding]; other site 386585008118 Q-loop/lid; other site 386585008119 ABC transporter signature motif; other site 386585008120 Walker B; other site 386585008121 D-loop; other site 386585008122 H-loop/switch region; other site 386585008123 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585008124 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 386585008125 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 386585008126 ligand binding site [chemical binding]; other site 386585008127 calcium binding site [ion binding]; other site 386585008128 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 386585008129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585008130 DNA binding site [nucleotide binding] 386585008131 domain linker motif; other site 386585008132 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 386585008133 dimerization interface (closed form) [polypeptide binding]; other site 386585008134 ligand binding site [chemical binding]; other site 386585008135 Predicted membrane protein [Function unknown]; Region: COG2311 386585008136 hypothetical protein; Provisional; Region: PRK10835 386585008137 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 386585008138 homodecamer interface [polypeptide binding]; other site 386585008139 active site 386585008140 putative catalytic site residues [active] 386585008141 zinc binding site [ion binding]; other site 386585008142 GTP-CH-I/GFRP interaction surface; other site 386585008143 Predicted esterase [General function prediction only]; Region: COG0627 386585008144 S-formylglutathione hydrolase; Region: PLN02442 386585008145 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 386585008146 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585008147 N-terminal plug; other site 386585008148 ligand-binding site [chemical binding]; other site 386585008149 lysine transporter; Provisional; Region: PRK10836 386585008150 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585008151 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 386585008152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585008153 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 386585008154 putative dimerization interface [polypeptide binding]; other site 386585008155 conserved hypothetical integral membrane protein; Region: TIGR00698 386585008156 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 386585008157 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 386585008158 AP (apurinic/apyrimidinic) site pocket; other site 386585008159 DNA interaction; other site 386585008160 Metal-binding active site; metal-binding site 386585008161 putative kinase; Provisional; Region: PRK09954 386585008162 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 386585008163 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 386585008164 substrate binding site [chemical binding]; other site 386585008165 ATP binding site [chemical binding]; other site 386585008166 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 386585008167 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 386585008168 Nucleoside recognition; Region: Gate; pfam07670 386585008169 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 386585008170 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 386585008171 active site 386585008172 tetramer interface [polypeptide binding]; other site 386585008173 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 386585008174 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 386585008175 ligand binding site [chemical binding]; other site 386585008176 flexible hinge region; other site 386585008177 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 386585008178 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 386585008179 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 386585008180 Nucleoside recognition; Region: Gate; pfam07670 386585008181 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 386585008182 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 386585008183 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 386585008184 substrate binding site [chemical binding]; other site 386585008185 ATP binding site [chemical binding]; other site 386585008186 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 386585008187 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 386585008188 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 386585008189 active site 386585008190 P-loop; other site 386585008191 phosphorylation site [posttranslational modification] 386585008192 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 386585008193 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 386585008194 putative substrate binding site [chemical binding]; other site 386585008195 putative ATP binding site [chemical binding]; other site 386585008196 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 386585008197 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585008198 active site 386585008199 phosphorylation site [posttranslational modification] 386585008200 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585008201 dimerization domain swap beta strand [polypeptide binding]; other site 386585008202 regulatory protein interface [polypeptide binding]; other site 386585008203 active site 386585008204 regulatory phosphorylation site [posttranslational modification]; other site 386585008205 sugar efflux transporter B; Provisional; Region: PRK15011 386585008206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008207 putative substrate translocation pore; other site 386585008208 elongation factor P; Provisional; Region: PRK04542 386585008209 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 386585008210 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 386585008211 RNA binding site [nucleotide binding]; other site 386585008212 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 386585008213 RNA binding site [nucleotide binding]; other site 386585008214 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 386585008215 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 386585008216 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 386585008217 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 386585008218 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 386585008219 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 386585008220 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 386585008221 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 386585008222 active site 386585008223 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 386585008224 NlpC/P60 family; Region: NLPC_P60; pfam00877 386585008225 phage resistance protein; Provisional; Region: PRK10551 386585008226 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 386585008227 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585008228 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 386585008229 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 386585008230 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 386585008231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585008232 dimer interface [polypeptide binding]; other site 386585008233 conserved gate region; other site 386585008234 putative PBP binding loops; other site 386585008235 ABC-ATPase subunit interface; other site 386585008236 microcin C ABC transporter permease; Provisional; Region: PRK15021 386585008237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585008238 dimer interface [polypeptide binding]; other site 386585008239 conserved gate region; other site 386585008240 putative PBP binding loops; other site 386585008241 ABC-ATPase subunit interface; other site 386585008242 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 386585008243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585008244 Walker A/P-loop; other site 386585008245 ATP binding site [chemical binding]; other site 386585008246 Q-loop/lid; other site 386585008247 ABC transporter signature motif; other site 386585008248 Walker B; other site 386585008249 D-loop; other site 386585008250 H-loop/switch region; other site 386585008251 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585008252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585008253 Walker A/P-loop; other site 386585008254 ATP binding site [chemical binding]; other site 386585008255 Q-loop/lid; other site 386585008256 ABC transporter signature motif; other site 386585008257 Walker B; other site 386585008258 D-loop; other site 386585008259 H-loop/switch region; other site 386585008260 hypothetical protein; Provisional; Region: PRK11835 386585008261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008262 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 386585008263 putative substrate translocation pore; other site 386585008264 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 386585008265 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585008266 RNA binding surface [nucleotide binding]; other site 386585008267 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 386585008268 active site 386585008269 uracil binding [chemical binding]; other site 386585008270 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 386585008271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585008272 ATP binding site [chemical binding]; other site 386585008273 putative Mg++ binding site [ion binding]; other site 386585008274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585008275 nucleotide binding region [chemical binding]; other site 386585008276 ATP-binding site [chemical binding]; other site 386585008277 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 386585008278 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 386585008279 5S rRNA interface [nucleotide binding]; other site 386585008280 CTC domain interface [polypeptide binding]; other site 386585008281 L16 interface [polypeptide binding]; other site 386585008282 nucleoid-associated protein NdpA; Validated; Region: PRK00378 386585008283 hypothetical protein; Provisional; Region: PRK13689 386585008284 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 386585008285 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 386585008286 Sulfatase; Region: Sulfatase; pfam00884 386585008287 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 386585008288 hypothetical protein; Provisional; Region: PRK09945 386585008289 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 386585008290 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585008291 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585008292 transcriptional regulator NarP; Provisional; Region: PRK10403 386585008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585008294 active site 386585008295 phosphorylation site [posttranslational modification] 386585008296 intermolecular recognition site; other site 386585008297 dimerization interface [polypeptide binding]; other site 386585008298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585008299 DNA binding residues [nucleotide binding] 386585008300 dimerization interface [polypeptide binding]; other site 386585008301 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 386585008302 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 386585008303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585008304 binding surface 386585008305 TPR motif; other site 386585008306 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 386585008307 catalytic residues [active] 386585008308 central insert; other site 386585008309 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 386585008310 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 386585008311 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 386585008312 heme exporter protein CcmC; Region: ccmC; TIGR01191 386585008313 heme exporter protein CcmB; Region: ccmB; TIGR01190 386585008314 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 386585008315 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 386585008316 Walker A/P-loop; other site 386585008317 ATP binding site [chemical binding]; other site 386585008318 Q-loop/lid; other site 386585008319 ABC transporter signature motif; other site 386585008320 Walker B; other site 386585008321 D-loop; other site 386585008322 H-loop/switch region; other site 386585008323 cytochrome c-type protein NapC; Provisional; Region: PRK10617 386585008324 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 386585008325 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 386585008326 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 386585008327 4Fe-4S binding domain; Region: Fer4_5; pfam12801 386585008328 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585008329 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 386585008330 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585008331 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585008332 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585008333 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 386585008334 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 386585008335 [4Fe-4S] binding site [ion binding]; other site 386585008336 molybdopterin cofactor binding site; other site 386585008337 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 386585008338 molybdopterin cofactor binding site; other site 386585008339 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 386585008340 ferredoxin-type protein; Provisional; Region: PRK10194 386585008341 ferredoxin-type protein NapF; Region: napF; TIGR00402 386585008342 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 386585008343 secondary substrate binding site; other site 386585008344 primary substrate binding site; other site 386585008345 inhibition loop; other site 386585008346 dimerization interface [polypeptide binding]; other site 386585008347 malate:quinone oxidoreductase; Validated; Region: PRK05257 386585008348 Predicted dehydrogenase [General function prediction only]; Region: COG0579 386585008349 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 386585008350 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 386585008351 Walker A/P-loop; other site 386585008352 ATP binding site [chemical binding]; other site 386585008353 Q-loop/lid; other site 386585008354 ABC transporter signature motif; other site 386585008355 Walker B; other site 386585008356 D-loop; other site 386585008357 H-loop/switch region; other site 386585008358 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 386585008359 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 386585008360 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 386585008361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585008362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585008363 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 386585008364 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 386585008365 DNA binding site [nucleotide binding] 386585008366 active site 386585008367 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 386585008368 outer membrane porin protein C; Provisional; Region: PRK10554 386585008369 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 386585008370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585008371 ATP binding site [chemical binding]; other site 386585008372 Mg2+ binding site [ion binding]; other site 386585008373 G-X-G motif; other site 386585008374 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 386585008375 putative binding surface; other site 386585008376 active site 386585008377 transcriptional regulator RcsB; Provisional; Region: PRK10840 386585008378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585008379 active site 386585008380 phosphorylation site [posttranslational modification] 386585008381 intermolecular recognition site; other site 386585008382 dimerization interface [polypeptide binding]; other site 386585008383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585008384 DNA binding residues [nucleotide binding] 386585008385 dimerization interface [polypeptide binding]; other site 386585008386 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 386585008387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585008388 dimer interface [polypeptide binding]; other site 386585008389 phosphorylation site [posttranslational modification] 386585008390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585008391 ATP binding site [chemical binding]; other site 386585008392 Mg2+ binding site [ion binding]; other site 386585008393 G-X-G motif; other site 386585008394 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 386585008395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585008396 active site 386585008397 phosphorylation site [posttranslational modification] 386585008398 intermolecular recognition site; other site 386585008399 dimerization interface [polypeptide binding]; other site 386585008400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 386585008401 Predicted secreted protein [Function unknown]; Region: COG5445 386585008402 Stage II sporulation protein; Region: SpoIID; pfam08486 386585008403 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 386585008404 Predicted secreted protein [Function unknown]; Region: COG5445 386585008405 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 386585008406 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 386585008407 MG2 domain; Region: A2M_N; pfam01835 386585008408 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 386585008409 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 386585008410 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 386585008411 Alpha-2-macroglobulin family; Region: A2M; pfam00207 386585008412 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 386585008413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 386585008414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 386585008415 DNA gyrase subunit A; Validated; Region: PRK05560 386585008416 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 386585008417 CAP-like domain; other site 386585008418 active site 386585008419 primary dimer interface [polypeptide binding]; other site 386585008420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585008421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585008422 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585008423 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585008424 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585008425 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585008426 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 386585008427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585008428 S-adenosylmethionine binding site [chemical binding]; other site 386585008429 adhesin; Provisional; Region: PRK09752 386585008430 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 386585008431 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585008432 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 386585008433 ATP cone domain; Region: ATP-cone; pfam03477 386585008434 Class I ribonucleotide reductase; Region: RNR_I; cd01679 386585008435 active site 386585008436 dimer interface [polypeptide binding]; other site 386585008437 catalytic residues [active] 386585008438 effector binding site; other site 386585008439 R2 peptide binding site; other site 386585008440 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 386585008441 dimer interface [polypeptide binding]; other site 386585008442 putative radical transfer pathway; other site 386585008443 diiron center [ion binding]; other site 386585008444 tyrosyl radical; other site 386585008445 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585008446 catalytic loop [active] 386585008447 iron binding site [ion binding]; other site 386585008448 hypothetical protein; Provisional; Region: PRK09902 386585008449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008450 putative substrate translocation pore; other site 386585008451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585008452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585008453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585008454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 386585008455 dimerization interface [polypeptide binding]; other site 386585008456 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 386585008457 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 386585008458 active site 386585008459 catalytic site [active] 386585008460 metal binding site [ion binding]; metal-binding site 386585008461 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 386585008462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008463 putative substrate translocation pore; other site 386585008464 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 386585008465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585008466 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 386585008467 FAD binding domain; Region: FAD_binding_2; pfam00890 386585008468 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 386585008469 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 386585008470 Cysteine-rich domain; Region: CCG; pfam02754 386585008471 Cysteine-rich domain; Region: CCG; pfam02754 386585008472 hypothetical protein; Provisional; Region: PRK09956 386585008473 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 386585008474 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 386585008475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008476 Transposase; Region: HTH_Tnp_1; cl17663 386585008477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585008478 putative transposase OrfB; Reviewed; Region: PHA02517 386585008479 HTH-like domain; Region: HTH_21; pfam13276 386585008480 Integrase core domain; Region: rve; pfam00665 386585008481 Integrase core domain; Region: rve_3; pfam13683 386585008482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008483 putative substrate translocation pore; other site 386585008484 L-rhamnonate dehydratase; Provisional; Region: PRK15440 386585008485 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 386585008486 putative active site pocket [active] 386585008487 putative metal binding site [ion binding]; other site 386585008488 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 386585008489 Transcriptional regulator [Transcription]; Region: IclR; COG1414 386585008490 Bacterial transcriptional regulator; Region: IclR; pfam01614 386585008491 hypothetical protein; Provisional; Region: PRK03673 386585008492 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 386585008493 putative MPT binding site; other site 386585008494 Competence-damaged protein; Region: CinA; cl00666 386585008495 YfaZ precursor; Region: YfaZ; pfam07437 386585008496 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 386585008497 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 386585008498 catalytic core [active] 386585008499 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 386585008500 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 386585008501 inhibitor-cofactor binding pocket; inhibition site 386585008502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585008503 catalytic residue [active] 386585008504 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 386585008505 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 386585008506 Ligand binding site; other site 386585008507 Putative Catalytic site; other site 386585008508 DXD motif; other site 386585008509 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 386585008510 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 386585008511 substrate binding site [chemical binding]; other site 386585008512 cosubstrate binding site; other site 386585008513 catalytic site [active] 386585008514 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 386585008515 active site 386585008516 hexamer interface [polypeptide binding]; other site 386585008517 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 386585008518 NAD binding site [chemical binding]; other site 386585008519 substrate binding site [chemical binding]; other site 386585008520 active site 386585008521 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 386585008522 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 386585008523 putative active site [active] 386585008524 putative catalytic site [active] 386585008525 putative Zn binding site [ion binding]; other site 386585008526 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 386585008527 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 386585008528 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 386585008529 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 386585008530 signal transduction protein PmrD; Provisional; Region: PRK15450 386585008531 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 386585008532 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 386585008533 acyl-activating enzyme (AAE) consensus motif; other site 386585008534 putative AMP binding site [chemical binding]; other site 386585008535 putative active site [active] 386585008536 putative CoA binding site [chemical binding]; other site 386585008537 O-succinylbenzoate synthase; Provisional; Region: PRK05105 386585008538 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 386585008539 active site 386585008540 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 386585008541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 386585008542 substrate binding site [chemical binding]; other site 386585008543 oxyanion hole (OAH) forming residues; other site 386585008544 trimer interface [polypeptide binding]; other site 386585008545 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 386585008546 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 386585008547 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 386585008548 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 386585008549 dimer interface [polypeptide binding]; other site 386585008550 tetramer interface [polypeptide binding]; other site 386585008551 PYR/PP interface [polypeptide binding]; other site 386585008552 TPP binding site [chemical binding]; other site 386585008553 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 386585008554 TPP-binding site; other site 386585008555 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 386585008556 isochorismate synthases; Region: isochor_syn; TIGR00543 386585008557 hypothetical protein; Provisional; Region: PRK10404 386585008558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585008559 Coenzyme A binding pocket [chemical binding]; other site 386585008560 ribonuclease BN; Region: true_RNase_BN; TIGR02649 386585008561 deubiquitinase; Provisional; Region: PRK11836 386585008562 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 386585008563 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 386585008564 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 386585008565 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585008566 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 386585008567 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585008568 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 386585008569 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 386585008570 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585008571 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 386585008572 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 386585008573 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 386585008574 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585008575 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 386585008576 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 386585008577 NADH dehydrogenase subunit G; Validated; Region: PRK08166 386585008578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585008579 catalytic loop [active] 386585008580 iron binding site [ion binding]; other site 386585008581 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 386585008582 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 386585008583 [4Fe-4S] binding site [ion binding]; other site 386585008584 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 386585008585 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 386585008586 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 386585008587 SLBB domain; Region: SLBB; pfam10531 386585008588 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 386585008589 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 386585008590 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 386585008591 putative dimer interface [polypeptide binding]; other site 386585008592 [2Fe-2S] cluster binding site [ion binding]; other site 386585008593 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 386585008594 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 386585008595 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 386585008596 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 386585008597 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 386585008598 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 386585008599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585008600 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 386585008601 putative dimerization interface [polypeptide binding]; other site 386585008602 aminotransferase AlaT; Validated; Region: PRK09265 386585008603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585008604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585008605 homodimer interface [polypeptide binding]; other site 386585008606 catalytic residue [active] 386585008607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 386585008608 Zn2+ binding site [ion binding]; other site 386585008609 Mg2+ binding site [ion binding]; other site 386585008610 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 386585008611 transmembrane helices; other site 386585008612 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 386585008613 TrkA-C domain; Region: TrkA_C; pfam02080 386585008614 TrkA-C domain; Region: TrkA_C; pfam02080 386585008615 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 386585008616 putative phosphatase; Provisional; Region: PRK11587 386585008617 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585008618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585008619 active site 386585008620 motif I; other site 386585008621 motif II; other site 386585008622 hypothetical protein; Validated; Region: PRK05445 386585008623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3092 386585008624 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 386585008625 phosphate acetyltransferase; Reviewed; Region: PRK05632 386585008626 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585008627 DRTGG domain; Region: DRTGG; pfam07085 386585008628 phosphate acetyltransferase; Region: pta; TIGR00651 386585008629 hypothetical protein; Provisional; Region: PRK11588 386585008630 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 386585008631 nudix motif; other site 386585008632 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 386585008633 active site 386585008634 metal binding site [ion binding]; metal-binding site 386585008635 homotetramer interface [polypeptide binding]; other site 386585008636 glutathione S-transferase; Provisional; Region: PRK15113 386585008637 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 386585008638 C-terminal domain interface [polypeptide binding]; other site 386585008639 GSH binding site (G-site) [chemical binding]; other site 386585008640 dimer interface [polypeptide binding]; other site 386585008641 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 386585008642 N-terminal domain interface [polypeptide binding]; other site 386585008643 putative dimer interface [polypeptide binding]; other site 386585008644 putative substrate binding pocket (H-site) [chemical binding]; other site 386585008645 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 386585008646 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 386585008647 C-terminal domain interface [polypeptide binding]; other site 386585008648 GSH binding site (G-site) [chemical binding]; other site 386585008649 dimer interface [polypeptide binding]; other site 386585008650 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 386585008651 N-terminal domain interface [polypeptide binding]; other site 386585008652 putative dimer interface [polypeptide binding]; other site 386585008653 active site 386585008654 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 386585008655 homooctamer interface [polypeptide binding]; other site 386585008656 active site 386585008657 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 386585008658 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 386585008659 putative NAD(P) binding site [chemical binding]; other site 386585008660 putative active site [active] 386585008661 hypothetical protein; Provisional; Region: PRK09956 386585008662 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 386585008663 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 386585008664 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 386585008665 Walker A/P-loop; other site 386585008666 ATP binding site [chemical binding]; other site 386585008667 Q-loop/lid; other site 386585008668 ABC transporter signature motif; other site 386585008669 Walker B; other site 386585008670 D-loop; other site 386585008671 H-loop/switch region; other site 386585008672 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 386585008673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585008674 dimer interface [polypeptide binding]; other site 386585008675 conserved gate region; other site 386585008676 putative PBP binding loops; other site 386585008677 ABC-ATPase subunit interface; other site 386585008678 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 386585008679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585008680 dimer interface [polypeptide binding]; other site 386585008681 conserved gate region; other site 386585008682 putative PBP binding loops; other site 386585008683 ABC-ATPase subunit interface; other site 386585008684 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 386585008685 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585008686 substrate binding pocket [chemical binding]; other site 386585008687 membrane-bound complex binding site; other site 386585008688 hinge residues; other site 386585008689 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 386585008690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585008691 substrate binding pocket [chemical binding]; other site 386585008692 membrane-bound complex binding site; other site 386585008693 hinge residues; other site 386585008694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 386585008695 amidophosphoribosyltransferase; Provisional; Region: PRK09246 386585008696 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 386585008697 active site 386585008698 tetramer interface [polypeptide binding]; other site 386585008699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585008700 active site 386585008701 colicin V production protein; Provisional; Region: PRK10845 386585008702 cell division protein DedD; Provisional; Region: PRK11633 386585008703 Sporulation related domain; Region: SPOR; pfam05036 386585008704 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 386585008705 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 386585008706 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 386585008707 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 386585008708 hypothetical protein; Provisional; Region: PRK10847 386585008709 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 386585008710 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 386585008711 dimerization interface 3.5A [polypeptide binding]; other site 386585008712 active site 386585008713 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 386585008714 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 386585008715 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 386585008716 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 386585008717 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 386585008718 ligand binding site [chemical binding]; other site 386585008719 NAD binding site [chemical binding]; other site 386585008720 catalytic site [active] 386585008721 homodimer interface [polypeptide binding]; other site 386585008722 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 386585008723 putative transporter; Provisional; Region: PRK12382 386585008724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008725 putative substrate translocation pore; other site 386585008726 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 386585008727 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 386585008728 dimer interface [polypeptide binding]; other site 386585008729 active site 386585008730 Uncharacterized conserved protein [Function unknown]; Region: COG4121 386585008731 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 386585008732 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 386585008733 YfcL protein; Region: YfcL; pfam08891 386585008734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 386585008735 hypothetical protein; Provisional; Region: PRK10621 386585008736 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 386585008737 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 386585008738 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 386585008739 Tetramer interface [polypeptide binding]; other site 386585008740 active site 386585008741 FMN-binding site [chemical binding]; other site 386585008742 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 386585008743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585008744 S-adenosylmethionine binding site [chemical binding]; other site 386585008745 hypothetical protein; Provisional; Region: PRK04946 386585008746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 386585008747 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 386585008748 Fimbrial protein; Region: Fimbrial; cl01416 386585008749 Fimbrial protein; Region: Fimbrial; cl01416 386585008750 Fimbrial protein; Region: Fimbrial; cl01416 386585008751 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 386585008752 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585008753 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585008754 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 386585008755 PapC N-terminal domain; Region: PapC_N; pfam13954 386585008756 Outer membrane usher protein; Region: Usher; pfam00577 386585008757 PapC C-terminal domain; Region: PapC_C; pfam13953 386585008758 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585008759 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 386585008760 catalytic core [active] 386585008761 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 386585008762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 386585008763 substrate binding site [chemical binding]; other site 386585008764 oxyanion hole (OAH) forming residues; other site 386585008765 trimer interface [polypeptide binding]; other site 386585008766 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 386585008767 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 386585008768 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 386585008769 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 386585008770 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 386585008771 dimer interface [polypeptide binding]; other site 386585008772 active site 386585008773 conserved hypothetical protein; Region: TIGR00743 386585008774 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 386585008775 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 386585008776 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 386585008777 integrase; Provisional; Region: PRK09692 386585008778 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585008779 active site 386585008780 Int/Topo IB signature motif; other site 386585008781 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 386585008782 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 386585008783 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 386585008784 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 386585008785 catalytic residues [active] 386585008786 catalytic nucleophile [active] 386585008787 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 386585008788 DNA-binding interface [nucleotide binding]; DNA binding site 386585008789 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 386585008790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008791 putative substrate translocation pore; other site 386585008792 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 386585008793 putative substrate binding site [chemical binding]; other site 386585008794 putative ATP binding site [chemical binding]; other site 386585008795 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 386585008796 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 386585008797 substrate binding [chemical binding]; other site 386585008798 active site 386585008799 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 386585008800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585008801 DNA binding site [nucleotide binding] 386585008802 domain linker motif; other site 386585008803 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 386585008804 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 386585008805 putative dimerization interface [polypeptide binding]; other site 386585008806 putative ligand binding site [chemical binding]; other site 386585008807 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 386585008808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585008809 catalytic residue [active] 386585008810 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 386585008811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585008812 putative substrate translocation pore; other site 386585008813 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 386585008814 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585008815 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585008816 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 386585008817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585008818 active site 386585008819 phosphorylation site [posttranslational modification] 386585008820 intermolecular recognition site; other site 386585008821 dimerization interface [polypeptide binding]; other site 386585008822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585008823 DNA binding residues [nucleotide binding] 386585008824 dimerization interface [polypeptide binding]; other site 386585008825 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 386585008826 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585008827 substrate binding pocket [chemical binding]; other site 386585008828 membrane-bound complex binding site; other site 386585008829 hinge residues; other site 386585008830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585008831 substrate binding pocket [chemical binding]; other site 386585008832 membrane-bound complex binding site; other site 386585008833 hinge residues; other site 386585008834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585008835 dimer interface [polypeptide binding]; other site 386585008836 phosphorylation site [posttranslational modification] 386585008837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585008838 ATP binding site [chemical binding]; other site 386585008839 Mg2+ binding site [ion binding]; other site 386585008840 G-X-G motif; other site 386585008841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585008842 active site 386585008843 phosphorylation site [posttranslational modification] 386585008844 intermolecular recognition site; other site 386585008845 dimerization interface [polypeptide binding]; other site 386585008846 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 386585008847 putative binding surface; other site 386585008848 active site 386585008849 CoA-transferase family III; Region: CoA_transf_3; cl19215 386585008850 CoA-transferase family III; Region: CoA_transf_3; cl19215 386585008851 putative transporter YfdV; Provisional; Region: PRK09903 386585008852 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 386585008853 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 386585008854 PYR/PP interface [polypeptide binding]; other site 386585008855 dimer interface [polypeptide binding]; other site 386585008856 TPP binding site [chemical binding]; other site 386585008857 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 386585008858 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 386585008859 TPP-binding site; other site 386585008860 dimer interface [polypeptide binding]; other site 386585008861 formyl-coenzyme A transferase; Provisional; Region: PRK05398 386585008862 hypothetical protein; Provisional; Region: PRK10316 386585008863 YfdX protein; Region: YfdX; pfam10938 386585008864 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 386585008865 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 386585008866 putative acyl-acceptor binding pocket; other site 386585008867 aminotransferase; Validated; Region: PRK08175 386585008868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585008869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585008870 homodimer interface [polypeptide binding]; other site 386585008871 catalytic residue [active] 386585008872 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 386585008873 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 386585008874 GAF domain; Region: GAF; pfam01590 386585008875 Histidine kinase; Region: His_kinase; pfam06580 386585008876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585008877 ATP binding site [chemical binding]; other site 386585008878 Mg2+ binding site [ion binding]; other site 386585008879 G-X-G motif; other site 386585008880 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 386585008881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585008882 active site 386585008883 phosphorylation site [posttranslational modification] 386585008884 intermolecular recognition site; other site 386585008885 dimerization interface [polypeptide binding]; other site 386585008886 LytTr DNA-binding domain; Region: LytTR; pfam04397 386585008887 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585008888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585008889 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585008890 dimerization domain swap beta strand [polypeptide binding]; other site 386585008891 regulatory protein interface [polypeptide binding]; other site 386585008892 active site 386585008893 regulatory phosphorylation site [posttranslational modification]; other site 386585008894 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 386585008895 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 386585008896 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 386585008897 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 386585008898 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585008899 active site 386585008900 phosphorylation site [posttranslational modification] 386585008901 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 386585008902 oligomer interface [polypeptide binding]; other site 386585008903 active site 386585008904 metal binding site [ion binding]; metal-binding site 386585008905 aminopeptidase; Provisional; Region: PRK09795 386585008906 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 386585008907 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 386585008908 active site 386585008909 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 386585008910 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 386585008911 active site 386585008912 P-loop; other site 386585008913 phosphorylation site [posttranslational modification] 386585008914 glucokinase; Provisional; Region: glk; PRK00292 386585008915 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585008916 nucleotide binding site [chemical binding]; other site 386585008917 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 386585008918 Cl- selectivity filter; other site 386585008919 Cl- binding residues [ion binding]; other site 386585008920 pore gating glutamate residue; other site 386585008921 dimer interface [polypeptide binding]; other site 386585008922 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 386585008923 manganese transport protein MntH; Reviewed; Region: PRK00701 386585008924 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 386585008925 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 386585008926 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 386585008927 Nucleoside recognition; Region: Gate; pfam07670 386585008928 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 386585008929 MASE1; Region: MASE1; pfam05231 386585008930 diguanylate cyclase; Region: GGDEF; smart00267 386585008931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585008932 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 386585008933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585008934 salt bridge; other site 386585008935 non-specific DNA binding site [nucleotide binding]; other site 386585008936 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 386585008937 sequence-specific DNA binding site [nucleotide binding]; other site 386585008938 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 386585008939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 386585008940 Probable transposase; Region: OrfB_IS605; pfam01385 386585008941 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 386585008942 Transposase IS200 like; Region: Y1_Tnp; pfam01797 386585008943 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 386585008944 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 386585008945 active site 386585008946 HIGH motif; other site 386585008947 KMSKS motif; other site 386585008948 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 386585008949 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 386585008950 active site 386585008951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585008952 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585008953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585008954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585008955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585008956 dimerization interface [polypeptide binding]; other site 386585008957 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 386585008958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 386585008959 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 386585008960 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 386585008961 nucleotide binding pocket [chemical binding]; other site 386585008962 K-X-D-G motif; other site 386585008963 catalytic site [active] 386585008964 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 386585008965 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 386585008966 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 386585008967 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 386585008968 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 386585008969 Dimer interface [polypeptide binding]; other site 386585008970 BRCT sequence motif; other site 386585008971 cell division protein ZipA; Provisional; Region: PRK03427 386585008972 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 386585008973 FtsZ protein binding site [polypeptide binding]; other site 386585008974 putative sulfate transport protein CysZ; Validated; Region: PRK04949 386585008975 cysteine synthase; Region: PLN02565 386585008976 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 386585008977 dimer interface [polypeptide binding]; other site 386585008978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585008979 catalytic residue [active] 386585008980 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585008981 dimerization domain swap beta strand [polypeptide binding]; other site 386585008982 regulatory protein interface [polypeptide binding]; other site 386585008983 active site 386585008984 regulatory phosphorylation site [posttranslational modification]; other site 386585008985 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 386585008986 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 386585008987 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 386585008988 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 386585008989 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 386585008990 HPr interaction site; other site 386585008991 glycerol kinase (GK) interaction site [polypeptide binding]; other site 386585008992 active site 386585008993 phosphorylation site [posttranslational modification] 386585008994 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 386585008995 dimer interface [polypeptide binding]; other site 386585008996 pyridoxal binding site [chemical binding]; other site 386585008997 ATP binding site [chemical binding]; other site 386585008998 hypothetical protein; Provisional; Region: PRK10318 386585008999 cysteine synthase; Region: PLN02565 386585009000 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 386585009001 dimer interface [polypeptide binding]; other site 386585009002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585009003 catalytic residue [active] 386585009004 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 386585009005 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 386585009006 Walker A/P-loop; other site 386585009007 ATP binding site [chemical binding]; other site 386585009008 Q-loop/lid; other site 386585009009 ABC transporter signature motif; other site 386585009010 Walker B; other site 386585009011 D-loop; other site 386585009012 H-loop/switch region; other site 386585009013 TOBE-like domain; Region: TOBE_3; pfam12857 386585009014 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 386585009015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585009016 dimer interface [polypeptide binding]; other site 386585009017 conserved gate region; other site 386585009018 putative PBP binding loops; other site 386585009019 ABC-ATPase subunit interface; other site 386585009020 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 386585009021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585009022 dimer interface [polypeptide binding]; other site 386585009023 conserved gate region; other site 386585009024 putative PBP binding loops; other site 386585009025 ABC-ATPase subunit interface; other site 386585009026 thiosulfate transporter subunit; Provisional; Region: PRK10852 386585009027 short chain dehydrogenase; Provisional; Region: PRK08226 386585009028 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 386585009029 NAD binding site [chemical binding]; other site 386585009030 homotetramer interface [polypeptide binding]; other site 386585009031 homodimer interface [polypeptide binding]; other site 386585009032 active site 386585009033 transcriptional regulator MurR; Provisional; Region: PRK15482 386585009034 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 386585009035 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 386585009036 putative active site [active] 386585009037 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 386585009038 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 386585009039 putative active site [active] 386585009040 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 386585009041 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585009042 active site turn [active] 386585009043 phosphorylation site [posttranslational modification] 386585009044 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 386585009045 putative periplasmic esterase; Provisional; Region: PRK03642 386585009046 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 386585009047 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 386585009048 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 386585009049 putative acetyltransferase; Provisional; Region: PRK03624 386585009050 Uncharacterized conserved protein [Function unknown]; Region: COG3375 386585009051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585009052 Coenzyme A binding pocket [chemical binding]; other site 386585009053 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 386585009054 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 386585009055 active site 386585009056 metal binding site [ion binding]; metal-binding site 386585009057 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 386585009058 transcriptional regulator EutR; Provisional; Region: PRK10130 386585009059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585009060 carboxysome structural protein EutK; Provisional; Region: PRK15466 386585009061 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 386585009062 Hexamer interface [polypeptide binding]; other site 386585009063 Hexagonal pore residue; other site 386585009064 EAP30/Vps36 family; Region: EAP30; pfam04157 386585009065 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 386585009066 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 386585009067 putative hexamer interface [polypeptide binding]; other site 386585009068 putative hexagonal pore; other site 386585009069 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 386585009070 putative hexamer interface [polypeptide binding]; other site 386585009071 putative hexagonal pore; other site 386585009072 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 386585009073 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 386585009074 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 386585009075 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 386585009076 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 386585009077 active site 386585009078 metal binding site [ion binding]; metal-binding site 386585009079 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 386585009080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585009081 nucleotide binding site [chemical binding]; other site 386585009082 nucleotide binding site [chemical binding]; other site 386585009083 Cell division protein FtsA; Region: FtsA; cl17206 386585009084 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 386585009085 putative catalytic cysteine [active] 386585009086 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 386585009087 Hexamer/Pentamer interface [polypeptide binding]; other site 386585009088 central pore; other site 386585009089 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 386585009090 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 386585009091 Hexamer interface [polypeptide binding]; other site 386585009092 Hexagonal pore residue; other site 386585009093 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 386585009094 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 386585009095 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 386585009096 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 386585009097 G1 box; other site 386585009098 GTP/Mg2+ binding site [chemical binding]; other site 386585009099 G2 box; other site 386585009100 Switch I region; other site 386585009101 G3 box; other site 386585009102 Switch II region; other site 386585009103 G4 box; other site 386585009104 G5 box; other site 386585009105 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 386585009106 putative hexamer interface [polypeptide binding]; other site 386585009107 putative hexagonal pore; other site 386585009108 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 386585009109 Malic enzyme, N-terminal domain; Region: malic; pfam00390 386585009110 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 386585009111 putative NAD(P) binding site [chemical binding]; other site 386585009112 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 386585009113 transaldolase-like protein; Provisional; Region: PTZ00411 386585009114 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 386585009115 active site 386585009116 dimer interface [polypeptide binding]; other site 386585009117 catalytic residue [active] 386585009118 transketolase; Reviewed; Region: PRK12753 386585009119 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 386585009120 TPP-binding site [chemical binding]; other site 386585009121 dimer interface [polypeptide binding]; other site 386585009122 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 386585009123 PYR/PP interface [polypeptide binding]; other site 386585009124 dimer interface [polypeptide binding]; other site 386585009125 TPP binding site [chemical binding]; other site 386585009126 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 386585009127 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 386585009128 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 386585009129 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 386585009130 dimer interface [polypeptide binding]; other site 386585009131 ADP-ribose binding site [chemical binding]; other site 386585009132 active site 386585009133 nudix motif; other site 386585009134 metal binding site [ion binding]; metal-binding site 386585009135 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 386585009136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009137 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 386585009138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585009139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585009140 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 386585009141 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 386585009142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585009143 dimerization interface [polypeptide binding]; other site 386585009144 Histidine kinase; Region: HisKA_3; pfam07730 386585009145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585009146 ATP binding site [chemical binding]; other site 386585009147 Mg2+ binding site [ion binding]; other site 386585009148 G-X-G motif; other site 386585009149 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 386585009150 MMPL family; Region: MMPL; cl14618 386585009151 MMPL family; Region: MMPL; cl14618 386585009152 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 386585009153 putative catalytic residues [active] 386585009154 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 386585009155 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 386585009156 metal binding site [ion binding]; metal-binding site 386585009157 dimer interface [polypeptide binding]; other site 386585009158 hypothetical protein; Provisional; Region: PRK13664 386585009159 putative hydrolase; Provisional; Region: PRK11460 386585009160 Predicted esterase [General function prediction only]; Region: COG0400 386585009161 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 386585009162 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 386585009163 Helicase; Region: Helicase_RecD; pfam05127 386585009164 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 386585009165 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 386585009166 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 386585009167 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 386585009168 ATP binding site [chemical binding]; other site 386585009169 active site 386585009170 substrate binding site [chemical binding]; other site 386585009171 lipoprotein; Provisional; Region: PRK11679 386585009172 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 386585009173 dimer interface [polypeptide binding]; other site 386585009174 active site 386585009175 catalytic residue [active] 386585009176 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 386585009177 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 386585009178 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 386585009179 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 386585009180 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 386585009181 catalytic triad [active] 386585009182 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 386585009183 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009184 hydrogenase 4 subunit B; Validated; Region: PRK06521 386585009185 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585009186 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 386585009187 hydrogenase 4 subunit D; Validated; Region: PRK06525 386585009188 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585009189 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 386585009190 hydrogenase 4 subunit F; Validated; Region: PRK06458 386585009191 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585009192 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 386585009193 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 386585009194 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 386585009195 hydrogenase 4 subunit H; Validated; Region: PRK08222 386585009196 4Fe-4S binding domain; Region: Fer4; pfam00037 386585009197 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 386585009198 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 386585009199 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 386585009200 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 386585009201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585009202 Walker A motif; other site 386585009203 ATP binding site [chemical binding]; other site 386585009204 Walker B motif; other site 386585009205 arginine finger; other site 386585009206 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 386585009207 putative formate transporter; Provisional; Region: focB; PRK09713 386585009208 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 386585009209 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 386585009210 Peptidase family M48; Region: Peptidase_M48; cl12018 386585009211 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 386585009212 catalytic residues [active] 386585009213 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 386585009214 DNA replication initiation factor; Provisional; Region: PRK08084 386585009215 uracil transporter; Provisional; Region: PRK10720 386585009216 uracil-xanthine permease; Region: ncs2; TIGR00801 386585009217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585009218 active site 386585009219 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 386585009220 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 386585009221 dimerization interface [polypeptide binding]; other site 386585009222 putative ATP binding site [chemical binding]; other site 386585009223 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 386585009224 active site 386585009225 substrate binding site [chemical binding]; other site 386585009226 cosubstrate binding site; other site 386585009227 catalytic site [active] 386585009228 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 386585009229 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 386585009230 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 386585009231 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 386585009232 domain interface [polypeptide binding]; other site 386585009233 active site 386585009234 catalytic site [active] 386585009235 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 386585009236 domain interface [polypeptide binding]; other site 386585009237 active site 386585009238 catalytic site [active] 386585009239 exopolyphosphatase; Provisional; Region: PRK10854 386585009240 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 386585009241 MASE1; Region: MASE1; pfam05231 386585009242 diguanylate cyclase; Region: GGDEF; smart00267 386585009243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585009244 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 386585009245 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 386585009246 GMP synthase; Reviewed; Region: guaA; PRK00074 386585009247 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 386585009248 AMP/PPi binding site [chemical binding]; other site 386585009249 candidate oxyanion hole; other site 386585009250 catalytic triad [active] 386585009251 potential glutamine specificity residues [chemical binding]; other site 386585009252 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 386585009253 ATP Binding subdomain [chemical binding]; other site 386585009254 Ligand Binding sites [chemical binding]; other site 386585009255 Dimerization subdomain; other site 386585009256 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 386585009257 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 386585009258 active site 386585009259 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 386585009260 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 386585009261 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 386585009262 generic binding surface II; other site 386585009263 generic binding surface I; other site 386585009264 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 386585009265 GTP-binding protein Der; Reviewed; Region: PRK00093 386585009266 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 386585009267 G1 box; other site 386585009268 GTP/Mg2+ binding site [chemical binding]; other site 386585009269 Switch I region; other site 386585009270 G2 box; other site 386585009271 Switch II region; other site 386585009272 G3 box; other site 386585009273 G4 box; other site 386585009274 G5 box; other site 386585009275 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 386585009276 G1 box; other site 386585009277 GTP/Mg2+ binding site [chemical binding]; other site 386585009278 Switch I region; other site 386585009279 G2 box; other site 386585009280 G3 box; other site 386585009281 Switch II region; other site 386585009282 G4 box; other site 386585009283 G5 box; other site 386585009284 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 386585009285 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 386585009286 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 386585009287 Trp docking motif [polypeptide binding]; other site 386585009288 active site 386585009289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 386585009290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 386585009291 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 386585009292 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 386585009293 dimer interface [polypeptide binding]; other site 386585009294 motif 1; other site 386585009295 active site 386585009296 motif 2; other site 386585009297 motif 3; other site 386585009298 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 386585009299 anticodon binding site; other site 386585009300 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 386585009301 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 386585009302 cytoskeletal protein RodZ; Provisional; Region: PRK10856 386585009303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585009304 non-specific DNA binding site [nucleotide binding]; other site 386585009305 salt bridge; other site 386585009306 sequence-specific DNA binding site [nucleotide binding]; other site 386585009307 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 386585009308 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 386585009309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585009310 FeS/SAM binding site; other site 386585009311 Nucleoside diphosphate kinase; Region: NDK; pfam00334 386585009312 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 386585009313 active site 386585009314 multimer interface [polypeptide binding]; other site 386585009315 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 386585009316 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009317 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 386585009318 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 386585009319 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 386585009320 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585009321 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 386585009322 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 386585009323 putative [Fe4-S4] binding site [ion binding]; other site 386585009324 putative molybdopterin cofactor binding site [chemical binding]; other site 386585009325 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 386585009326 putative molybdopterin cofactor binding site; other site 386585009327 penicillin-binding protein 1C; Provisional; Region: PRK11240 386585009328 Transglycosylase; Region: Transgly; pfam00912 386585009329 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 386585009330 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 386585009331 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 386585009332 MG2 domain; Region: A2M_N; pfam01835 386585009333 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 386585009334 Alpha-2-macroglobulin family; Region: A2M; pfam00207 386585009335 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 386585009336 surface patch; other site 386585009337 thioester region; other site 386585009338 specificity defining residues; other site 386585009339 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 386585009340 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 386585009341 active site residue [active] 386585009342 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 386585009343 active site residue [active] 386585009344 SseB protein N-terminal domain; Region: SseB; pfam07179 386585009345 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 386585009346 SseB protein C-terminal domain; Region: SseB_C; pfam14581 386585009347 aminopeptidase B; Provisional; Region: PRK05015 386585009348 Peptidase; Region: DUF3663; pfam12404 386585009349 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 386585009350 interface (dimer of trimers) [polypeptide binding]; other site 386585009351 Substrate-binding/catalytic site; other site 386585009352 Zn-binding sites [ion binding]; other site 386585009353 hypothetical protein; Provisional; Region: PRK10721 386585009354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585009355 catalytic loop [active] 386585009356 iron binding site [ion binding]; other site 386585009357 chaperone protein HscA; Provisional; Region: hscA; PRK05183 386585009358 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 386585009359 nucleotide binding site [chemical binding]; other site 386585009360 putative NEF/HSP70 interaction site [polypeptide binding]; other site 386585009361 SBD interface [polypeptide binding]; other site 386585009362 co-chaperone HscB; Provisional; Region: hscB; PRK05014 386585009363 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 386585009364 HSP70 interaction site [polypeptide binding]; other site 386585009365 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 386585009366 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 386585009367 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 386585009368 trimerization site [polypeptide binding]; other site 386585009369 active site 386585009370 cysteine desulfurase; Provisional; Region: PRK14012 386585009371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585009372 catalytic residue [active] 386585009373 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 386585009374 Rrf2 family protein; Region: rrf2_super; TIGR00738 386585009375 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 386585009376 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 386585009377 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 386585009378 active site 386585009379 dimerization interface [polypeptide binding]; other site 386585009380 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 386585009381 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 386585009382 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 386585009383 PRD domain; Region: PRD; pfam00874 386585009384 PRD domain; Region: PRD; pfam00874 386585009385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585009386 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 386585009387 putative substrate translocation pore; other site 386585009388 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 386585009389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585009390 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 386585009391 putative dimerization interface [polypeptide binding]; other site 386585009392 putative substrate binding pocket [chemical binding]; other site 386585009393 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 386585009394 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 386585009395 iron-sulfur cluster [ion binding]; other site 386585009396 [2Fe-2S] cluster binding site [ion binding]; other site 386585009397 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 386585009398 beta subunit interface [polypeptide binding]; other site 386585009399 alpha subunit interface [polypeptide binding]; other site 386585009400 active site 386585009401 substrate binding site [chemical binding]; other site 386585009402 Fe binding site [ion binding]; other site 386585009403 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 386585009404 inter-subunit interface; other site 386585009405 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 386585009406 [2Fe-2S] cluster binding site [ion binding]; other site 386585009407 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 386585009408 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 386585009409 NAD binding site [chemical binding]; other site 386585009410 active site 386585009411 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 386585009412 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 386585009413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585009414 Reductase C-terminal; Region: Reductase_C; pfam14759 386585009415 Predicted membrane protein [Function unknown]; Region: COG2259 386585009416 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 386585009417 active site 386585009418 catalytic residues [active] 386585009419 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 386585009420 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585009421 NAD(P) binding site [chemical binding]; other site 386585009422 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 386585009423 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585009424 TM-ABC transporter signature motif; other site 386585009425 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 386585009426 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585009427 Walker A/P-loop; other site 386585009428 ATP binding site [chemical binding]; other site 386585009429 Q-loop/lid; other site 386585009430 ABC transporter signature motif; other site 386585009431 Walker B; other site 386585009432 D-loop; other site 386585009433 H-loop/switch region; other site 386585009434 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585009435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 386585009436 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 386585009437 ligand binding site [chemical binding]; other site 386585009438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585009439 TPR motif; other site 386585009440 Tetratricopeptide repeat; Region: TPR_16; pfam13432 386585009441 binding surface 386585009442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585009443 binding surface 386585009444 Tetratricopeptide repeat; Region: TPR_16; pfam13432 386585009445 TPR motif; other site 386585009446 TPR repeat; Region: TPR_11; pfam13414 386585009447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585009448 TPR motif; other site 386585009449 binding surface 386585009450 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 386585009451 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 386585009452 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585009453 nucleotide binding site [chemical binding]; other site 386585009454 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 386585009455 dimer interface [polypeptide binding]; other site 386585009456 active site 386585009457 glycine-pyridoxal phosphate binding site [chemical binding]; other site 386585009458 folate binding site [chemical binding]; other site 386585009459 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 386585009460 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 386585009461 heme-binding site [chemical binding]; other site 386585009462 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 386585009463 FAD binding pocket [chemical binding]; other site 386585009464 FAD binding motif [chemical binding]; other site 386585009465 phosphate binding motif [ion binding]; other site 386585009466 beta-alpha-beta structure motif; other site 386585009467 NAD binding pocket [chemical binding]; other site 386585009468 Heme binding pocket [chemical binding]; other site 386585009469 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 386585009470 response regulator GlrR; Provisional; Region: PRK15115 386585009471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585009472 active site 386585009473 phosphorylation site [posttranslational modification] 386585009474 intermolecular recognition site; other site 386585009475 dimerization interface [polypeptide binding]; other site 386585009476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585009477 Walker A motif; other site 386585009478 ATP binding site [chemical binding]; other site 386585009479 Walker B motif; other site 386585009480 arginine finger; other site 386585009481 hypothetical protein; Provisional; Region: PRK10722 386585009482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 386585009483 HAMP domain; Region: HAMP; pfam00672 386585009484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585009485 dimer interface [polypeptide binding]; other site 386585009486 phosphorylation site [posttranslational modification] 386585009487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585009488 ATP binding site [chemical binding]; other site 386585009489 Mg2+ binding site [ion binding]; other site 386585009490 G-X-G motif; other site 386585009491 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 386585009492 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 386585009493 dimerization interface [polypeptide binding]; other site 386585009494 ATP binding site [chemical binding]; other site 386585009495 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 386585009496 dimerization interface [polypeptide binding]; other site 386585009497 ATP binding site [chemical binding]; other site 386585009498 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 386585009499 putative active site [active] 386585009500 catalytic triad [active] 386585009501 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 386585009502 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585009503 substrate binding pocket [chemical binding]; other site 386585009504 membrane-bound complex binding site; other site 386585009505 hinge residues; other site 386585009506 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585009507 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585009508 catalytic residue [active] 386585009509 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 386585009510 nucleoside/Zn binding site; other site 386585009511 dimer interface [polypeptide binding]; other site 386585009512 catalytic motif [active] 386585009513 hypothetical protein; Provisional; Region: PRK11590 386585009514 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 386585009515 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 386585009516 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 386585009517 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 386585009518 putative active site [active] 386585009519 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 386585009520 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 386585009521 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 386585009522 active site 386585009523 hydrophilic channel; other site 386585009524 dimerization interface [polypeptide binding]; other site 386585009525 catalytic residues [active] 386585009526 active site lid [active] 386585009527 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 386585009528 Recombination protein O N terminal; Region: RecO_N; pfam11967 386585009529 Recombination protein O C terminal; Region: RecO_C; pfam02565 386585009530 GTPase Era; Reviewed; Region: era; PRK00089 386585009531 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 386585009532 G1 box; other site 386585009533 GTP/Mg2+ binding site [chemical binding]; other site 386585009534 Switch I region; other site 386585009535 G2 box; other site 386585009536 Switch II region; other site 386585009537 G3 box; other site 386585009538 G4 box; other site 386585009539 G5 box; other site 386585009540 KH domain; Region: KH_2; pfam07650 386585009541 ribonuclease III; Reviewed; Region: rnc; PRK00102 386585009542 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 386585009543 dimerization interface [polypeptide binding]; other site 386585009544 active site 386585009545 metal binding site [ion binding]; metal-binding site 386585009546 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 386585009547 dsRNA binding site [nucleotide binding]; other site 386585009548 signal peptidase I; Provisional; Region: PRK10861 386585009549 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 386585009550 Catalytic site [active] 386585009551 GTP-binding protein LepA; Provisional; Region: PRK05433 386585009552 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 386585009553 G1 box; other site 386585009554 putative GEF interaction site [polypeptide binding]; other site 386585009555 GTP/Mg2+ binding site [chemical binding]; other site 386585009556 Switch I region; other site 386585009557 G2 box; other site 386585009558 G3 box; other site 386585009559 Switch II region; other site 386585009560 G4 box; other site 386585009561 G5 box; other site 386585009562 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 386585009563 Elongation Factor G, domain II; Region: EFG_II; pfam14492 386585009564 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 386585009565 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 386585009566 SoxR reducing system protein RseC; Provisional; Region: PRK10862 386585009567 anti-sigma E factor; Provisional; Region: rseB; PRK09455 386585009568 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 386585009569 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 386585009570 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 386585009571 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 386585009572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 386585009573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 386585009574 DNA binding residues [nucleotide binding] 386585009575 L-aspartate oxidase; Provisional; Region: PRK09077 386585009576 L-aspartate oxidase; Provisional; Region: PRK06175 386585009577 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 386585009578 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 386585009579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585009580 S-adenosylmethionine binding site [chemical binding]; other site 386585009581 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 386585009582 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 386585009583 ATP binding site [chemical binding]; other site 386585009584 Mg++ binding site [ion binding]; other site 386585009585 motif III; other site 386585009586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585009587 nucleotide binding region [chemical binding]; other site 386585009588 ATP-binding site [chemical binding]; other site 386585009589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585009590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585009591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 386585009592 dimerization interface [polypeptide binding]; other site 386585009593 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 386585009594 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 386585009595 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 386585009596 ligand binding site [chemical binding]; other site 386585009597 active site 386585009598 UGI interface [polypeptide binding]; other site 386585009599 catalytic site [active] 386585009600 putative methyltransferase; Provisional; Region: PRK10864 386585009601 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 386585009602 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 386585009603 thioredoxin 2; Provisional; Region: PRK10996 386585009604 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 386585009605 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 386585009606 catalytic residues [active] 386585009607 Uncharacterized conserved protein [Function unknown]; Region: COG3148 386585009608 similar to E. coli YfiQ; disrupted by frameshift 386585009609 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 386585009610 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 386585009611 domain interface [polypeptide binding]; other site 386585009612 putative active site [active] 386585009613 catalytic site [active] 386585009614 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 386585009615 domain interface [polypeptide binding]; other site 386585009616 putative active site [active] 386585009617 catalytic site [active] 386585009618 lipoprotein; Provisional; Region: PRK10759 386585009619 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 386585009620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585009621 putative substrate translocation pore; other site 386585009622 protein disaggregation chaperone; Provisional; Region: PRK10865 386585009623 Clp amino terminal domain; Region: Clp_N; pfam02861 386585009624 Clp amino terminal domain; Region: Clp_N; pfam02861 386585009625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585009626 Walker A motif; other site 386585009627 ATP binding site [chemical binding]; other site 386585009628 Walker B motif; other site 386585009629 arginine finger; other site 386585009630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585009631 Walker A motif; other site 386585009632 ATP binding site [chemical binding]; other site 386585009633 Walker B motif; other site 386585009634 arginine finger; other site 386585009635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 386585009636 hypothetical protein; Provisional; Region: PRK10723 386585009637 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 386585009638 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585009639 RNA binding surface [nucleotide binding]; other site 386585009640 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 386585009641 active site 386585009642 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 386585009643 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 386585009644 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 386585009645 30S subunit binding site; other site 386585009646 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 386585009647 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 386585009648 Prephenate dehydratase; Region: PDT; pfam00800 386585009649 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 386585009650 putative L-Phe binding site [chemical binding]; other site 386585009651 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 386585009652 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 386585009653 prephenate dehydrogenase; Validated; Region: PRK08507 386585009654 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 386585009655 lipoprotein; Provisional; Region: PRK11443 386585009656 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 386585009657 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 386585009658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585009659 metal binding site [ion binding]; metal-binding site 386585009660 active site 386585009661 I-site; other site 386585009662 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 386585009663 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585009664 ligand binding site [chemical binding]; other site 386585009665 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 386585009666 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 386585009667 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 386585009668 RimM N-terminal domain; Region: RimM; pfam01782 386585009669 PRC-barrel domain; Region: PRC; pfam05239 386585009670 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 386585009671 signal recognition particle protein; Provisional; Region: PRK10867 386585009672 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 386585009673 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 386585009674 P loop; other site 386585009675 GTP binding site [chemical binding]; other site 386585009676 Signal peptide binding domain; Region: SRP_SPB; pfam02978 386585009677 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 386585009678 hypothetical protein; Provisional; Region: PRK11573 386585009679 Domain of unknown function DUF21; Region: DUF21; pfam01595 386585009680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 386585009681 Transporter associated domain; Region: CorC_HlyC; smart01091 386585009682 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 386585009683 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 386585009684 dimer interface [polypeptide binding]; other site 386585009685 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 386585009686 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 386585009687 recombination and repair protein; Provisional; Region: PRK10869 386585009688 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 386585009689 Walker A/P-loop; other site 386585009690 ATP binding site [chemical binding]; other site 386585009691 Q-loop/lid; other site 386585009692 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 386585009693 Q-loop/lid; other site 386585009694 ABC transporter signature motif; other site 386585009695 Walker B; other site 386585009696 D-loop; other site 386585009697 H-loop/switch region; other site 386585009698 SmpA / OmlA family; Region: SmpA_OmlA; cl19285 386585009699 hypothetical protein; Validated; Region: PRK01777 386585009700 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 386585009701 putative coenzyme Q binding site [chemical binding]; other site 386585009702 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 386585009703 SmpB-tmRNA interface; other site 386585009704 DinI-like family; Region: DinI; pfam06183 386585009705 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 386585009706 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585009707 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 386585009708 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 386585009709 Transposase; Region: HTH_Tnp_1; cl17663 386585009710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585009711 putative transposase OrfB; Reviewed; Region: PHA02517 386585009712 HTH-like domain; Region: HTH_21; pfam13276 386585009713 Integrase core domain; Region: rve; pfam00665 386585009714 Integrase core domain; Region: rve_3; pfam13683 386585009715 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585009716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585009717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585009718 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585009719 Transposase; Region: HTH_Tnp_1; pfam01527 386585009720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585009721 similar to endolysin; disrupted by frameshift 386585009722 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 386585009723 Lysis protein S; Region: Lysis_S; pfam04971 386585009724 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 386585009725 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585009726 Antitermination protein; Region: Antiterm; pfam03589 386585009727 Antitermination protein; Region: Antiterm; pfam03589 386585009728 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 386585009729 putative protein phosphatase; Region: PHA02239 386585009730 active site 386585009731 metal binding site [ion binding]; metal-binding site 386585009732 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 386585009733 HNH endonuclease; Region: HNH_3; pfam13392 386585009734 AP2 domain; Region: AP2; pfam00847 386585009735 similar to transposase; disrupted by frameshift 386585009736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 386585009737 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 386585009738 active site 386585009739 catalytic residues [active] 386585009740 DNA binding site [nucleotide binding] 386585009741 Int/Topo IB signature motif; other site 386585009742 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585009743 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 386585009744 active site 386585009745 catalytic residues [active] 386585009746 DNA binding site [nucleotide binding] 386585009747 Int/Topo IB signature motif; other site 386585009748 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 386585009749 hypothetical protein; Provisional; Region: PRK09945 386585009750 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 386585009751 hypothetical protein; Provisional; Region: PRK09945 386585009752 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 386585009753 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 386585009754 Autotransporter beta-domain; Region: Autotransporter; pfam03797 386585009755 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 386585009756 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 386585009757 active site 386585009758 catalytic site [active] 386585009759 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 386585009760 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 386585009761 substrate binding pocket [chemical binding]; other site 386585009762 active site 386585009763 iron coordination sites [ion binding]; other site 386585009764 Predicted dehydrogenase [General function prediction only]; Region: COG0579 386585009765 hydroxyglutarate oxidase; Provisional; Region: PRK11728 386585009766 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 386585009767 tetramerization interface [polypeptide binding]; other site 386585009768 NAD(P) binding site [chemical binding]; other site 386585009769 catalytic residues [active] 386585009770 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585009771 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 386585009772 inhibitor-cofactor binding pocket; inhibition site 386585009773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585009774 catalytic residue [active] 386585009775 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 386585009776 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585009777 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 386585009778 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 386585009779 DNA-binding site [nucleotide binding]; DNA binding site 386585009780 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585009781 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 386585009782 bacterial OsmY and nodulation domain; Region: BON; smart00749 386585009783 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585009784 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 386585009785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585009786 dimerization interface [polypeptide binding]; other site 386585009787 putative DNA binding site [nucleotide binding]; other site 386585009788 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585009789 putative Zn2+ binding site [ion binding]; other site 386585009790 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 386585009791 active site residue [active] 386585009792 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 386585009793 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 386585009794 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 386585009795 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 386585009796 hypothetical protein; Provisional; Region: PRK10556 386585009797 hypothetical protein; Provisional; Region: PRK10132 386585009798 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 386585009799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585009800 DNA-binding site [nucleotide binding]; DNA binding site 386585009801 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585009802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585009803 homodimer interface [polypeptide binding]; other site 386585009804 catalytic residue [active] 386585009805 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 386585009806 Uncharacterized conserved protein [Function unknown]; Region: COG2128 386585009807 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 386585009808 catalytic residues [active] 386585009809 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 386585009810 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 386585009811 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 386585009812 Class I ribonucleotide reductase; Region: RNR_I; cd01679 386585009813 active site 386585009814 dimer interface [polypeptide binding]; other site 386585009815 catalytic residues [active] 386585009816 effector binding site; other site 386585009817 R2 peptide binding site; other site 386585009818 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 386585009819 dimer interface [polypeptide binding]; other site 386585009820 putative radical transfer pathway; other site 386585009821 diiron center [ion binding]; other site 386585009822 tyrosyl radical; other site 386585009823 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 386585009824 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 386585009825 Walker A/P-loop; other site 386585009826 ATP binding site [chemical binding]; other site 386585009827 Q-loop/lid; other site 386585009828 ABC transporter signature motif; other site 386585009829 Walker B; other site 386585009830 D-loop; other site 386585009831 H-loop/switch region; other site 386585009832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 386585009833 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 386585009834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585009835 dimer interface [polypeptide binding]; other site 386585009836 conserved gate region; other site 386585009837 putative PBP binding loops; other site 386585009838 ABC-ATPase subunit interface; other site 386585009839 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 386585009840 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 386585009841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585009842 putative substrate translocation pore; other site 386585009843 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 386585009844 putative L-valine exporter; Provisional; Region: PRK10408 386585009845 transcriptional repressor MprA; Provisional; Region: PRK10870 386585009846 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585009847 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 386585009848 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585009849 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585009850 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 386585009851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585009852 putative substrate translocation pore; other site 386585009853 S-ribosylhomocysteinase; Provisional; Region: PRK02260 386585009854 glutamate--cysteine ligase; Provisional; Region: PRK02107 386585009855 Predicted membrane protein [Function unknown]; Region: COG1238 386585009856 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 386585009857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585009858 active site 386585009859 motif I; other site 386585009860 motif II; other site 386585009861 carbon storage regulator; Provisional; Region: PRK01712 386585009862 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 386585009863 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 386585009864 motif 1; other site 386585009865 active site 386585009866 motif 2; other site 386585009867 motif 3; other site 386585009868 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 386585009869 DHHA1 domain; Region: DHHA1; pfam02272 386585009870 recombination regulator RecX; Reviewed; Region: recX; PRK00117 386585009871 recombinase A; Provisional; Region: recA; PRK09354 386585009872 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 386585009873 hexamer interface [polypeptide binding]; other site 386585009874 Walker A motif; other site 386585009875 ATP binding site [chemical binding]; other site 386585009876 Walker B motif; other site 386585009877 hypothetical protein; Validated; Region: PRK03661 386585009878 murein hydrolase B; Provisional; Region: PRK10760 386585009879 lytic murein transglycosylase B; Region: MltB; TIGR02282 386585009880 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585009881 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585009882 similar to PTS system, glucitol/sorbitol-specific IIC component SRLA_ECOLI gi|1789054; disrupted by frameshift 386585009883 similar to PTS system, glucitol/sorbitol-specific IIB component SRLE_ECOLI gi|1789055; disrupted by frameshift 386585009884 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 386585009885 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 386585009886 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 386585009887 putative NAD(P) binding site [chemical binding]; other site 386585009888 active site 386585009889 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 386585009890 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 386585009891 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 386585009892 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585009893 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 386585009894 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 386585009895 putative active site [active] 386585009896 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 386585009897 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 386585009898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 386585009899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585009900 Walker A motif; other site 386585009901 ATP binding site [chemical binding]; other site 386585009902 Walker B motif; other site 386585009903 arginine finger; other site 386585009904 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 386585009905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 386585009906 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 386585009907 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 386585009908 iron binding site [ion binding]; other site 386585009909 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 386585009910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585009911 Acylphosphatase; Region: Acylphosphatase; pfam00708 386585009912 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 386585009913 HypF finger; Region: zf-HYPF; pfam07503 386585009914 HypF finger; Region: zf-HYPF; pfam07503 386585009915 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 386585009916 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 386585009917 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 386585009919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585009920 DNA binding site [nucleotide binding] 386585009921 domain linker motif; other site 386585009922 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 386585009923 dimerization interface (closed form) [polypeptide binding]; other site 386585009924 ligand binding site [chemical binding]; other site 386585009925 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 386585009926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585009927 active site turn [active] 386585009928 phosphorylation site [posttranslational modification] 386585009929 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 386585009930 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 386585009931 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 386585009932 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 386585009933 nickel binding site [ion binding]; other site 386585009934 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 386585009935 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 386585009936 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 386585009937 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009938 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 386585009939 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 386585009940 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 386585009941 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 386585009942 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 386585009943 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 386585009944 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 386585009945 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009946 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585009947 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 386585009948 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 386585009949 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 386585009950 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 386585009951 hydrogenase assembly chaperone; Provisional; Region: PRK10409 386585009952 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 386585009953 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 386585009954 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 386585009955 dimerization interface [polypeptide binding]; other site 386585009956 ATP binding site [chemical binding]; other site 386585009957 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 386585009958 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 386585009959 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 386585009960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585009961 Walker A motif; other site 386585009962 ATP binding site [chemical binding]; other site 386585009963 Walker B motif; other site 386585009964 arginine finger; other site 386585009965 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 386585009966 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 386585009967 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 386585009968 MutS domain I; Region: MutS_I; pfam01624 386585009969 MutS domain II; Region: MutS_II; pfam05188 386585009970 MutS domain III; Region: MutS_III; pfam05192 386585009971 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 386585009972 Walker A/P-loop; other site 386585009973 ATP binding site [chemical binding]; other site 386585009974 Q-loop/lid; other site 386585009975 ABC transporter signature motif; other site 386585009976 Walker B; other site 386585009977 D-loop; other site 386585009978 H-loop/switch region; other site 386585009979 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 386585009980 active site 386585009981 metal binding site [ion binding]; metal-binding site 386585009982 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 386585009983 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 386585009984 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 386585009985 Transcriptional regulators [Transcription]; Region: MarR; COG1846 386585009986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 386585009987 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 386585009988 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 386585009989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 386585009990 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 386585009991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 386585009992 DNA binding residues [nucleotide binding] 386585009993 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 386585009994 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585009995 Peptidase family M23; Region: Peptidase_M23; pfam01551 386585009996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585009997 S-adenosylmethionine binding site [chemical binding]; other site 386585009998 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 386585009999 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 386585010000 Permutation of conserved domain; other site 386585010001 active site 386585010002 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 386585010003 homotrimer interaction site [polypeptide binding]; other site 386585010004 zinc binding site [ion binding]; other site 386585010005 CDP-binding sites; other site 386585010006 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 386585010007 substrate binding site; other site 386585010008 dimer interface; other site 386585010009 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 386585010010 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 386585010011 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 386585010012 ligand-binding site [chemical binding]; other site 386585010013 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 386585010014 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 386585010015 CysD dimerization site [polypeptide binding]; other site 386585010016 G1 box; other site 386585010017 putative GEF interaction site [polypeptide binding]; other site 386585010018 GTP/Mg2+ binding site [chemical binding]; other site 386585010019 Switch I region; other site 386585010020 G2 box; other site 386585010021 G3 box; other site 386585010022 Switch II region; other site 386585010023 G4 box; other site 386585010024 G5 box; other site 386585010025 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 386585010026 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 386585010027 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 386585010028 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 386585010029 Active Sites [active] 386585010030 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 386585010031 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 386585010032 metal binding site [ion binding]; metal-binding site 386585010033 putative ssRNA endonuclease; Provisional; Region: PRK11558 386585010034 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 386585010035 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 386585010036 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 386585010037 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 386585010038 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 386585010039 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 386585010040 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 386585010041 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 386585010042 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 386585010043 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 386585010044 Hok/gef family; Region: HOK_GEF; pfam01848 386585010045 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 386585010046 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 386585010047 Active Sites [active] 386585010048 sulfite reductase subunit beta; Provisional; Region: PRK13504 386585010049 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 386585010050 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 386585010051 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 386585010052 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585010053 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 386585010054 Flavodoxin; Region: Flavodoxin_1; pfam00258 386585010055 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 386585010056 FAD binding pocket [chemical binding]; other site 386585010057 FAD binding motif [chemical binding]; other site 386585010058 catalytic residues [active] 386585010059 NAD binding pocket [chemical binding]; other site 386585010060 phosphate binding motif [ion binding]; other site 386585010061 beta-alpha-beta structure motif; other site 386585010062 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 386585010063 homohexamer interface [polypeptide binding]; other site 386585010064 putative substrate stabilizing pore; other site 386585010065 pterin binding site; other site 386585010066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585010067 putative oxidoreductase FixC; Provisional; Region: PRK10157 386585010068 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 386585010069 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 386585010070 similar to E. coli YgcQ; disrupted by frameshift 386585010071 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 386585010072 Ligand binding site [chemical binding]; other site 386585010073 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 386585010074 similar to E. coli YgcS; disrupted by frameshift 386585010075 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 386585010076 FAD binding domain; Region: FAD_binding_4; pfam01565 386585010077 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 386585010078 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 386585010079 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 386585010080 NADP binding site [chemical binding]; other site 386585010081 homodimer interface [polypeptide binding]; other site 386585010082 active site 386585010083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585010084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585010085 putative substrate translocation pore; other site 386585010086 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 386585010087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 386585010088 nucleotide binding site [chemical binding]; other site 386585010089 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 386585010090 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 386585010091 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 386585010092 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 386585010093 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 386585010094 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 386585010095 enolase; Provisional; Region: eno; PRK00077 386585010096 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 386585010097 dimer interface [polypeptide binding]; other site 386585010098 metal binding site [ion binding]; metal-binding site 386585010099 substrate binding pocket [chemical binding]; other site 386585010100 CTP synthetase; Validated; Region: pyrG; PRK05380 386585010101 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 386585010102 Catalytic site [active] 386585010103 active site 386585010104 UTP binding site [chemical binding]; other site 386585010105 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 386585010106 active site 386585010107 putative oxyanion hole; other site 386585010108 catalytic triad [active] 386585010109 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 386585010110 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 386585010111 homodimer interface [polypeptide binding]; other site 386585010112 metal binding site [ion binding]; metal-binding site 386585010113 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 386585010114 homodimer interface [polypeptide binding]; other site 386585010115 active site 386585010116 putative chemical substrate binding site [chemical binding]; other site 386585010117 metal binding site [ion binding]; metal-binding site 386585010118 toxin MazF; Provisional; Region: PRK09907 386585010119 antitoxin MazE; Provisional; Region: PRK09798 386585010120 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 386585010121 HD domain; Region: HD_4; pfam13328 386585010122 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 386585010123 synthetase active site [active] 386585010124 NTP binding site [chemical binding]; other site 386585010125 metal binding site [ion binding]; metal-binding site 386585010126 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 386585010127 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 386585010128 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 386585010129 TRAM domain; Region: TRAM; pfam01938 386585010130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585010131 S-adenosylmethionine binding site [chemical binding]; other site 386585010132 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 386585010133 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 386585010134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585010135 dimerization interface [polypeptide binding]; other site 386585010136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585010137 dimer interface [polypeptide binding]; other site 386585010138 phosphorylation site [posttranslational modification] 386585010139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585010140 ATP binding site [chemical binding]; other site 386585010141 Mg2+ binding site [ion binding]; other site 386585010142 G-X-G motif; other site 386585010143 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 386585010144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585010145 active site 386585010146 phosphorylation site [posttranslational modification] 386585010147 intermolecular recognition site; other site 386585010148 dimerization interface [polypeptide binding]; other site 386585010149 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 386585010150 putative binding surface; other site 386585010151 active site 386585010152 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 386585010153 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 386585010154 active site 386585010155 tetramer interface [polypeptide binding]; other site 386585010156 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 386585010157 metal binding site [ion binding]; metal-binding site 386585010158 substrate binding pocket [chemical binding]; other site 386585010159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585010160 D-galactonate transporter; Region: 2A0114; TIGR00893 386585010161 putative substrate translocation pore; other site 386585010162 flavodoxin; Provisional; Region: PRK08105 386585010163 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 386585010164 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 386585010165 probable active site [active] 386585010166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 386585010167 SecY interacting protein Syd; Provisional; Region: PRK04968 386585010168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 386585010169 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 386585010170 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 386585010171 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 386585010172 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 386585010173 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 386585010174 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585010175 serine transporter; Region: stp; TIGR00814 386585010176 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 386585010177 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 386585010178 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 386585010179 flap endonuclease-like protein; Provisional; Region: PRK09482 386585010180 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 386585010181 active site 386585010182 metal binding site 1 [ion binding]; metal-binding site 386585010183 putative 5' ssDNA interaction site; other site 386585010184 metal binding site 3; metal-binding site 386585010185 metal binding site 2 [ion binding]; metal-binding site 386585010186 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 386585010187 putative DNA binding site [nucleotide binding]; other site 386585010188 putative metal binding site [ion binding]; other site 386585010189 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 386585010190 dimer interface [polypeptide binding]; other site 386585010191 active site 386585010192 metal binding site [ion binding]; metal-binding site 386585010193 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 386585010194 intersubunit interface [polypeptide binding]; other site 386585010195 active site 386585010196 Zn2+ binding site [ion binding]; other site 386585010197 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 386585010198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585010199 putative substrate translocation pore; other site 386585010200 L-fucose isomerase; Provisional; Region: fucI; PRK10991 386585010201 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 386585010202 hexamer (dimer of trimers) interface [polypeptide binding]; other site 386585010203 trimer interface [polypeptide binding]; other site 386585010204 substrate binding site [chemical binding]; other site 386585010205 Mn binding site [ion binding]; other site 386585010206 L-fuculokinase; Provisional; Region: PRK10331 386585010207 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 386585010208 putative N- and C-terminal domain interface [polypeptide binding]; other site 386585010209 putative active site [active] 386585010210 putative MgATP binding site [chemical binding]; other site 386585010211 putative catalytic site [active] 386585010212 metal binding site [ion binding]; metal-binding site 386585010213 putative carbohydrate binding site [chemical binding]; other site 386585010214 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 386585010215 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 386585010216 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 386585010217 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585010218 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 386585010219 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 386585010220 hypothetical protein; Provisional; Region: PRK10873 386585010221 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 386585010222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585010223 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 386585010224 dimerization interface [polypeptide binding]; other site 386585010225 substrate binding pocket [chemical binding]; other site 386585010226 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 386585010227 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 386585010228 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 386585010229 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585010230 catalytic residue [active] 386585010231 CsdA-binding activator; Provisional; Region: PRK15019 386585010232 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 386585010233 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 386585010234 putative ATP binding site [chemical binding]; other site 386585010235 putative substrate interface [chemical binding]; other site 386585010236 murein transglycosylase A; Provisional; Region: mltA; PRK11162 386585010237 MltA specific insert domain; Region: MltA; smart00925 386585010238 3D domain; Region: 3D; pfam06725 386585010239 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 386585010240 AMIN domain; Region: AMIN; pfam11741 386585010241 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 386585010242 active site 386585010243 metal binding site [ion binding]; metal-binding site 386585010244 N-acetylglutamate synthase; Validated; Region: PRK05279 386585010245 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 386585010246 putative feedback inhibition sensing region; other site 386585010247 putative nucleotide binding site [chemical binding]; other site 386585010248 putative substrate binding site [chemical binding]; other site 386585010249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585010250 Coenzyme A binding pocket [chemical binding]; other site 386585010251 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 386585010252 AAA domain; Region: AAA_30; pfam13604 386585010253 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 386585010254 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 386585010255 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 386585010256 protease3; Provisional; Region: PRK15101 386585010257 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 386585010258 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 386585010259 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 386585010260 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 386585010261 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 386585010262 hypothetical protein; Provisional; Region: PRK10332 386585010263 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 386585010264 hypothetical protein; Provisional; Region: PRK11521 386585010265 hypothetical protein; Provisional; Region: PRK10557 386585010266 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 386585010267 hypothetical protein; Provisional; Region: PRK10506 386585010268 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 386585010269 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 386585010270 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 386585010271 dimerization interface [polypeptide binding]; other site 386585010272 active site 386585010273 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 386585010274 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 386585010275 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 386585010276 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 386585010277 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 386585010278 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 386585010279 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 386585010280 putative active site [active] 386585010281 Ap4A binding site [chemical binding]; other site 386585010282 nudix motif; other site 386585010283 putative metal binding site [ion binding]; other site 386585010284 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 386585010285 putative DNA-binding cleft [nucleotide binding]; other site 386585010286 putative DNA clevage site; other site 386585010287 molecular lever; other site 386585010288 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 386585010289 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 386585010290 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585010291 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585010292 active site 386585010293 catalytic tetrad [active] 386585010294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585010295 putative substrate translocation pore; other site 386585010296 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 386585010297 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 386585010298 putative acyl-acceptor binding pocket; other site 386585010299 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 386585010300 acyl-activating enzyme (AAE) consensus motif; other site 386585010301 putative AMP binding site [chemical binding]; other site 386585010302 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 386585010303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585010304 DNA binding site [nucleotide binding] 386585010305 domain linker motif; other site 386585010306 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 386585010307 dimerization interface (closed form) [polypeptide binding]; other site 386585010308 ligand binding site [chemical binding]; other site 386585010309 diaminopimelate decarboxylase; Provisional; Region: PRK11165 386585010310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 386585010311 active site 386585010312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 386585010313 substrate binding site [chemical binding]; other site 386585010314 catalytic residues [active] 386585010315 dimer interface [polypeptide binding]; other site 386585010316 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 386585010317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585010318 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 386585010319 putative dimerization interface [polypeptide binding]; other site 386585010320 putative racemase; Provisional; Region: PRK10200 386585010321 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 386585010322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585010323 putative substrate translocation pore; other site 386585010324 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 386585010325 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 386585010326 NADP binding site [chemical binding]; other site 386585010327 homodimer interface [polypeptide binding]; other site 386585010328 active site 386585010329 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 386585010330 putative acyltransferase; Provisional; Region: PRK05790 386585010331 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 386585010332 dimer interface [polypeptide binding]; other site 386585010333 active site 386585010334 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585010335 serine transporter; Region: stp; TIGR00814 386585010336 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 386585010337 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 386585010338 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 386585010339 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 386585010340 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 386585010341 Tetratricopeptide repeat; Region: TPR_3; pfam07720 386585010342 Tetratricopeptide repeat; Region: TPR_3; pfam07720 386585010343 transcriptional regulator; Provisional; Region: PRK11906 386585010344 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 386585010345 DNA binding site [nucleotide binding] 386585010346 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 386585010347 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585010348 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585010349 catalytic residue [active] 386585010350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585010351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 386585010352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585010353 DNA binding residues [nucleotide binding] 386585010354 dimerization interface [polypeptide binding]; other site 386585010355 invasion protein OrgB; Provisional; Region: PRK15322 386585010356 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; pfam09482 386585010357 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 386585010358 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 386585010359 Type III secretion needle MxiH like; Region: MxiH; cl09641 386585010360 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; cl12363 386585010361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585010362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 386585010363 DNA binding residues [nucleotide binding] 386585010364 dimerization interface [polypeptide binding]; other site 386585010365 type III secretion system protein SpaS; Validated; Region: PRK08156 386585010366 similar to type III secretion protein EpaR; disrupted by frameshift 386585010367 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 386585010368 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 386585010369 type III secretion system protein SpaO; Validated; Region: PRK08158 386585010370 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 386585010371 Surface presentation of antigens protein; Region: SPAN; cl19597 386585010372 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 386585010373 ATP synthase SpaL; Validated; Region: PRK08149 386585010374 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 386585010375 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 386585010376 Walker A motif; other site 386585010377 ATP binding site [chemical binding]; other site 386585010378 Walker B motif; other site 386585010379 type III secretion system protein InvA; Provisional; Region: PRK15337 386585010380 type III secretion system regulator InvE; Provisional; Region: PRK15338 386585010381 HrpJ-like domain; Region: HrpJ; pfam07201 386585010382 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 386585010383 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 386585010384 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 386585010385 transcriptional regulator InvF; Provisional; Region: PRK15340 386585010386 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 386585010387 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 386585010388 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 386585010389 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 386585010390 Peptidase family M23; Region: Peptidase_M23; pfam01551 386585010391 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 386585010392 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 386585010393 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 386585010394 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 386585010395 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 386585010396 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 386585010397 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 386585010398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 386585010399 catalytic loop [active] 386585010400 iron binding site [ion binding]; other site 386585010401 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 386585010402 GAF domain; Region: GAF; cl17456 386585010403 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 386585010404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585010405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585010406 Walker A motif; other site 386585010407 ATP binding site [chemical binding]; other site 386585010408 Walker B motif; other site 386585010409 arginine finger; other site 386585010410 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 386585010411 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 386585010412 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 386585010413 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 386585010414 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 386585010415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585010416 catalytic residue [active] 386585010417 peptidase; Reviewed; Region: PRK13004 386585010418 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 386585010419 putative metal binding site [ion binding]; other site 386585010420 putative dimer interface [polypeptide binding]; other site 386585010421 D-hydantoinase; Region: D-hydantoinase; TIGR02033 386585010422 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 386585010423 tetramer interface [polypeptide binding]; other site 386585010424 active site 386585010425 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 386585010426 putative substrate binding site [chemical binding]; other site 386585010427 nucleotide binding site [chemical binding]; other site 386585010428 nucleotide binding site [chemical binding]; other site 386585010429 homodimer interface [polypeptide binding]; other site 386585010430 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 386585010431 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 386585010432 XdhC Rossmann domain; Region: XdhC_C; pfam13478 386585010433 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 386585010434 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 386585010435 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 386585010436 Ligand binding site; other site 386585010437 metal-binding site 386585010438 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 386585010439 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 386585010440 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585010441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585010442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585010443 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 386585010444 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 386585010445 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 386585010446 active site 386585010447 putative substrate binding pocket [chemical binding]; other site 386585010448 FAD binding domain; Region: FAD_binding_4; cl19922 386585010449 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 386585010450 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 386585010451 probable selenate reductase, molybdenum-binding subunit; Region: Se_sel_red_Mo; TIGR03313 386585010452 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 386585010453 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 386585010454 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 386585010455 uracil-xanthine permease; Region: ncs2; TIGR00801 386585010456 Sulfate transporter family; Region: Sulfate_transp; cl19250 386585010457 guanine deaminase; Provisional; Region: PRK09228 386585010458 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 386585010459 active site 386585010460 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 386585010461 Sulfate transporter family; Region: Sulfate_transp; cl19250 386585010462 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585010463 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 386585010464 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 386585010465 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585010466 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 386585010467 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 386585010468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 386585010469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585010470 Sulfate transporter family; Region: Sulfate_transp; cl19250 386585010471 xanthine permease; Region: pbuX; TIGR03173 386585010472 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 386585010473 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 386585010474 active site 386585010475 metal binding site [ion binding]; metal-binding site 386585010476 nudix motif; other site 386585010477 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 386585010478 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 386585010479 dimer interface [polypeptide binding]; other site 386585010480 putative anticodon binding site; other site 386585010481 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 386585010482 motif 1; other site 386585010483 active site 386585010484 motif 2; other site 386585010485 motif 3; other site 386585010486 peptide chain release factor 2; Validated; Region: prfB; PRK00578 386585010487 This domain is found in peptide chain release factors; Region: PCRF; smart00937 386585010488 RF-1 domain; Region: RF-1; pfam00472 386585010489 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 386585010490 DHH family; Region: DHH; pfam01368 386585010491 DHHA1 domain; Region: DHHA1; pfam02272 386585010492 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 386585010493 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 386585010494 dimerization domain [polypeptide binding]; other site 386585010495 dimer interface [polypeptide binding]; other site 386585010496 catalytic residues [active] 386585010497 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 386585010498 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 386585010499 active site 386585010500 Int/Topo IB signature motif; other site 386585010501 flavodoxin FldB; Provisional; Region: PRK12359 386585010502 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 386585010503 hypothetical protein; Provisional; Region: PRK10878 386585010504 putative global regulator; Reviewed; Region: PRK09559 386585010505 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 386585010506 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 386585010507 hemolysin; Provisional; Region: PRK15087 386585010508 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 386585010509 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 386585010510 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 386585010511 glycine dehydrogenase; Provisional; Region: PRK05367 386585010512 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 386585010513 tetramer interface [polypeptide binding]; other site 386585010514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585010515 catalytic residue [active] 386585010516 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 386585010517 tetramer interface [polypeptide binding]; other site 386585010518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585010519 catalytic residue [active] 386585010520 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 386585010521 lipoyl attachment site [posttranslational modification]; other site 386585010522 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 386585010523 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 386585010524 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 386585010525 oxidoreductase; Provisional; Region: PRK08013 386585010526 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 386585010527 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 386585010528 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 386585010529 proline aminopeptidase P II; Provisional; Region: PRK10879 386585010530 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 386585010531 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 386585010532 active site 386585010533 hypothetical protein; Reviewed; Region: PRK01736 386585010534 Z-ring-associated protein; Provisional; Region: PRK10972 386585010535 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 386585010536 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 386585010537 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 386585010538 ligand binding site [chemical binding]; other site 386585010539 NAD binding site [chemical binding]; other site 386585010540 tetramer interface [polypeptide binding]; other site 386585010541 catalytic site [active] 386585010542 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 386585010543 L-serine binding site [chemical binding]; other site 386585010544 ACT domain interface; other site 386585010545 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 386585010546 tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585010547 active site 386585010548 dimer interface [polypeptide binding]; other site 386585010549 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 386585010550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585010551 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 386585010552 putative dimerization interface [polypeptide binding]; other site 386585010553 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 386585010554 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 386585010555 active site 386585010556 substrate binding site [chemical binding]; other site 386585010557 coenzyme B12 binding site [chemical binding]; other site 386585010558 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 386585010559 B12 binding site [chemical binding]; other site 386585010560 cobalt ligand [ion binding]; other site 386585010561 LAO/AO transport system ATPase; Region: lao; TIGR00750 386585010562 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 386585010563 Walker A; other site 386585010564 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 386585010565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 386585010566 substrate binding site [chemical binding]; other site 386585010567 oxyanion hole (OAH) forming residues; other site 386585010568 trimer interface [polypeptide binding]; other site 386585010569 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 386585010570 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 386585010571 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 386585010572 similar to transcriptional regulator LYSR-type; disrupted by frameshift 386585010573 oxidative stress defense protein; Provisional; Region: PRK11087 386585010574 arginine exporter protein; Provisional; Region: PRK09304 386585010575 mechanosensitive channel MscS; Provisional; Region: PRK10334 386585010576 Conserved TM helix; Region: TM_helix; pfam05552 386585010577 Mechanosensitive ion channel; Region: MS_channel; pfam00924 386585010578 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 386585010579 active site 386585010580 intersubunit interface [polypeptide binding]; other site 386585010581 zinc binding site [ion binding]; other site 386585010582 Na+ binding site [ion binding]; other site 386585010583 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 386585010584 substrate binding site [chemical binding]; other site 386585010585 hinge regions; other site 386585010586 ADP binding site [chemical binding]; other site 386585010587 catalytic site [active] 386585010588 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 386585010589 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 386585010590 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 386585010591 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 386585010592 trimer interface [polypeptide binding]; other site 386585010593 putative Zn binding site [ion binding]; other site 386585010594 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 386585010595 WxL domain surface cell wall-binding; Region: WxL; pfam13731 386585010596 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 386585010597 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 386585010598 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 386585010599 Walker A/P-loop; other site 386585010600 ATP binding site [chemical binding]; other site 386585010601 Q-loop/lid; other site 386585010602 ABC transporter signature motif; other site 386585010603 Walker B; other site 386585010604 D-loop; other site 386585010605 H-loop/switch region; other site 386585010606 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 386585010607 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 386585010608 Walker A/P-loop; other site 386585010609 ATP binding site [chemical binding]; other site 386585010610 Q-loop/lid; other site 386585010611 ABC transporter signature motif; other site 386585010612 Walker B; other site 386585010613 D-loop; other site 386585010614 H-loop/switch region; other site 386585010615 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 386585010616 active site 386585010617 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 386585010618 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 386585010619 putative active site [active] 386585010620 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 386585010621 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585010622 putative NAD(P) binding site [chemical binding]; other site 386585010623 catalytic Zn binding site [ion binding]; other site 386585010624 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 386585010625 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 386585010626 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 386585010627 active site 386585010628 P-loop; other site 386585010629 phosphorylation site [posttranslational modification] 386585010630 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585010631 active site 386585010632 phosphorylation site [posttranslational modification] 386585010633 transketolase; Reviewed; Region: PRK12753 386585010634 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 386585010635 TPP-binding site [chemical binding]; other site 386585010636 dimer interface [polypeptide binding]; other site 386585010637 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 386585010638 PYR/PP interface [polypeptide binding]; other site 386585010639 dimer interface [polypeptide binding]; other site 386585010640 TPP binding site [chemical binding]; other site 386585010641 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 386585010642 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 386585010643 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 386585010644 oligomer interface [polypeptide binding]; other site 386585010645 putative active site [active] 386585010646 Mn binding site [ion binding]; other site 386585010647 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 386585010648 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 386585010649 dimer interface [polypeptide binding]; other site 386585010650 active site 386585010651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 386585010652 catalytic residues [active] 386585010653 substrate binding site [chemical binding]; other site 386585010654 Virulence promoting factor; Region: YqgB; pfam11036 386585010655 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 386585010656 S-adenosylmethionine synthetase; Validated; Region: PRK05250 386585010657 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 386585010658 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 386585010659 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 386585010660 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 386585010661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585010662 putative substrate translocation pore; other site 386585010663 hypothetical protein; Provisional; Region: PRK04860 386585010664 DNA-specific endonuclease I; Provisional; Region: PRK15137 386585010665 RNA methyltransferase, RsmE family; Region: TIGR00046 386585010666 glutathione synthetase; Provisional; Region: PRK05246 386585010667 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 386585010668 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 386585010669 hypothetical protein; Validated; Region: PRK00228 386585010670 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 386585010671 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 386585010672 Walker A motif; other site 386585010673 ATP binding site [chemical binding]; other site 386585010674 Walker B motif; other site 386585010675 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 386585010676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 386585010677 catalytic residue [active] 386585010678 YGGT family; Region: YGGT; pfam02325 386585010679 Predicted integral membrane protein [Function unknown]; Region: COG0762 386585010680 hypothetical protein; Validated; Region: PRK05090 386585010681 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 386585010682 active site 386585010683 dimerization interface [polypeptide binding]; other site 386585010684 HemN family oxidoreductase; Provisional; Region: PRK05660 386585010685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585010686 FeS/SAM binding site; other site 386585010687 HemN C-terminal domain; Region: HemN_C; pfam06969 386585010688 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 386585010689 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 386585010690 active site 386585010691 homodimer interface [polypeptide binding]; other site 386585010692 hypothetical protein; Provisional; Region: PRK10626 386585010693 hypothetical protein; Provisional; Region: PRK11702 386585010694 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 386585010695 adenine DNA glycosylase; Provisional; Region: PRK10880 386585010696 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 386585010697 minor groove reading motif; other site 386585010698 helix-hairpin-helix signature motif; other site 386585010699 substrate binding pocket [chemical binding]; other site 386585010700 active site 386585010701 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 386585010702 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 386585010703 DNA binding and oxoG recognition site [nucleotide binding] 386585010704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 386585010705 murein transglycosylase C; Provisional; Region: mltC; PRK11671 386585010706 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 386585010707 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585010708 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585010709 catalytic residue [active] 386585010710 nucleoside transporter; Region: 2A0110; TIGR00889 386585010711 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 386585010712 ornithine decarboxylase; Provisional; Region: PRK13578 386585010713 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 386585010714 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 386585010715 homodimer interface [polypeptide binding]; other site 386585010716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585010717 catalytic residue [active] 386585010718 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 386585010719 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 386585010720 integrase; Provisional; Region: PRK09692 386585010721 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585010722 active site 386585010723 Int/Topo IB signature motif; other site 386585010724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 386585010725 Homeodomain-like domain; Region: HTH_23; pfam13384 386585010726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585010727 Transposase; Region: HTH_Tnp_1; pfam01527 386585010728 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585010729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585010730 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585010731 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585010732 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585010733 Nuclease-related domain; Region: NERD; pfam08378 386585010734 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 386585010735 similar to transposase; disrupted by frameshift 386585010736 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 386585010737 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 386585010738 Winged helix-turn helix; Region: HTH_29; pfam13551 386585010739 Homeodomain-like domain; Region: HTH_23; pfam13384 386585010740 Homeodomain-like domain; Region: HTH_32; pfam13565 386585010741 DDE superfamily endonuclease; Region: DDE_3; cl19249 386585010742 similar to adherence factors Efa1; disrupted by frameshift 386585010743 putative transposase OrfB; Reviewed; Region: PHA02517 386585010744 HTH-like domain; Region: HTH_21; pfam13276 386585010745 Integrase core domain; Region: rve; pfam00665 386585010746 Integrase core domain; Region: rve_3; pfam13683 386585010747 Transposase; Region: HTH_Tnp_1; cl17663 386585010748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585010749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585010750 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585010751 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585010752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585010753 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585010754 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585010755 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585010756 similar to hypothetical protein L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1; disrupted by frameshift 386585010757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585010758 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585010759 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585010760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585010761 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585010762 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585010763 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585010764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585010765 Transposase; Region: HTH_Tnp_1; cl17663 386585010766 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 386585010767 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 386585010768 CHAP domain; Region: CHAP; pfam05257 386585010769 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 386585010770 putative S-transferase; Provisional; Region: PRK11752 386585010771 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 386585010772 C-terminal domain interface [polypeptide binding]; other site 386585010773 GSH binding site (G-site) [chemical binding]; other site 386585010774 dimer interface [polypeptide binding]; other site 386585010775 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 386585010776 dimer interface [polypeptide binding]; other site 386585010777 N-terminal domain interface [polypeptide binding]; other site 386585010778 active site 386585010779 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 386585010780 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 386585010781 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 386585010782 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 386585010783 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 386585010784 putative substrate-binding site; other site 386585010785 nickel binding site [ion binding]; other site 386585010786 hydrogenase 2 large subunit; Provisional; Region: PRK10467 386585010787 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 386585010788 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 386585010789 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585010790 hydrogenase 2 small subunit; Provisional; Region: PRK10468 386585010791 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 386585010792 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 386585010793 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 386585010794 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 386585010795 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 386585010796 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 386585010797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585010798 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 386585010799 active site 386585010800 catalytic tetrad [active] 386585010801 hypothetical protein; Provisional; Region: PRK05208 386585010802 oxidoreductase; Provisional; Region: PRK07985 386585010803 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 386585010804 NAD binding site [chemical binding]; other site 386585010805 metal binding site [ion binding]; metal-binding site 386585010806 active site 386585010807 biopolymer transport protein ExbD; Provisional; Region: PRK11267 386585010808 biopolymer transport protein ExbB; Provisional; Region: PRK10414 386585010809 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 386585010810 homodimer interface [polypeptide binding]; other site 386585010811 substrate-cofactor binding pocket; other site 386585010812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585010813 catalytic residue [active] 386585010814 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 386585010815 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 386585010816 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 386585010817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585010818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585010819 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 386585010820 dimer interface [polypeptide binding]; other site 386585010821 active site 386585010822 metal binding site [ion binding]; metal-binding site 386585010823 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 386585010824 active site 386585010825 catalytic tetrad [active] 386585010826 putative outer membrane lipoprotein; Provisional; Region: PRK09973 386585010827 hypothetical protein; Provisional; Region: PRK01254 386585010828 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 386585010829 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 386585010830 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 386585010831 FtsI repressor; Provisional; Region: PRK10883 386585010832 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 386585010833 Domain 2 interface [polypeptide binding]; other site 386585010834 Domain 3 interface [polypeptide binding]; other site 386585010835 trinuclear Cu binding site [ion binding]; other site 386585010836 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 386585010837 Domain 1 interface [polypeptide binding]; other site 386585010838 Domain 3 interface [polypeptide binding]; other site 386585010839 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 386585010840 Domain 2 interface [polypeptide binding]; other site 386585010841 Domain 1 interface [polypeptide binding]; other site 386585010842 Type 1 (T1) Cu binding site [ion binding]; other site 386585010843 trinuclear Cu binding site [ion binding]; other site 386585010844 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 386585010845 putative acyl-acceptor binding pocket; other site 386585010846 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 386585010847 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 386585010848 CAP-like domain; other site 386585010849 active site 386585010850 primary dimer interface [polypeptide binding]; other site 386585010851 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 386585010852 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 386585010853 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 386585010854 peptide binding site [polypeptide binding]; other site 386585010855 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 386585010856 TIGR00156 family protein; Region: TIGR00156 386585010857 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 386585010858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585010859 active site 386585010860 phosphorylation site [posttranslational modification] 386585010861 intermolecular recognition site; other site 386585010862 dimerization interface [polypeptide binding]; other site 386585010863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585010864 DNA binding site [nucleotide binding] 386585010865 similar to E. coli YgiY; disrupted by frameshift 386585010866 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 386585010867 Uncharacterized conserved protein [Function unknown]; Region: COG1359 386585010868 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 386585010869 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 386585010870 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 386585010871 putative active site [active] 386585010872 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 386585010873 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 386585010874 siderophore binding site; other site 386585010875 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585010876 ABC-ATPase subunit interface; other site 386585010877 dimer interface [polypeptide binding]; other site 386585010878 putative PBP binding regions; other site 386585010879 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585010880 ABC-ATPase subunit interface; other site 386585010881 dimer interface [polypeptide binding]; other site 386585010882 putative PBP binding regions; other site 386585010883 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 386585010884 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 386585010885 Walker A/P-loop; other site 386585010886 ATP binding site [chemical binding]; other site 386585010887 Q-loop/lid; other site 386585010888 ABC transporter signature motif; other site 386585010889 Walker B; other site 386585010890 D-loop; other site 386585010891 H-loop/switch region; other site 386585010892 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 386585010893 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585010894 N-terminal plug; other site 386585010895 ligand-binding site [chemical binding]; other site 386585010896 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 386585010897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585010898 ATP binding site [chemical binding]; other site 386585010899 Mg2+ binding site [ion binding]; other site 386585010900 G-X-G motif; other site 386585010901 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 386585010902 anchoring element; other site 386585010903 dimer interface [polypeptide binding]; other site 386585010904 ATP binding site [chemical binding]; other site 386585010905 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 386585010906 active site 386585010907 metal binding site [ion binding]; metal-binding site 386585010908 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 386585010909 esterase YqiA; Provisional; Region: PRK11071 386585010910 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 386585010911 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 386585010912 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 386585010913 active site 386585010914 metal binding site [ion binding]; metal-binding site 386585010915 hexamer interface [polypeptide binding]; other site 386585010916 putative dehydrogenase; Provisional; Region: PRK11039 386585010917 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 386585010918 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 386585010919 dimer interface [polypeptide binding]; other site 386585010920 ADP-ribose binding site [chemical binding]; other site 386585010921 active site 386585010922 nudix motif; other site 386585010923 metal binding site [ion binding]; metal-binding site 386585010924 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 386585010925 Outer membrane efflux protein; Region: OEP; pfam02321 386585010926 Outer membrane efflux protein; Region: OEP; pfam02321 386585010927 hypothetical protein; Provisional; Region: PRK11653 386585010928 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 386585010929 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 386585010930 putative active site [active] 386585010931 metal binding site [ion binding]; metal-binding site 386585010932 zinc transporter ZupT; Provisional; Region: PRK04201 386585010933 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 386585010934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 386585010935 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 386585010936 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 386585010937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 386585010938 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 386585010939 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 386585010940 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 386585010941 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 386585010942 putative ribose interaction site [chemical binding]; other site 386585010943 putative ADP binding site [chemical binding]; other site 386585010944 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 386585010945 active site 386585010946 nucleotide binding site [chemical binding]; other site 386585010947 HIGH motif; other site 386585010948 KMSKS motif; other site 386585010949 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 386585010950 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 386585010951 metal binding triad; other site 386585010952 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 386585010953 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 386585010954 metal binding triad; other site 386585010955 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 386585010956 Uncharacterized conserved protein [Function unknown]; Region: COG3025 386585010957 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 386585010958 putative active site [active] 386585010959 putative metal binding residues [ion binding]; other site 386585010960 signature motif; other site 386585010961 putative triphosphate binding site [ion binding]; other site 386585010962 CHAD domain; Region: CHAD; pfam05235 386585010963 SH3 domain-containing protein; Provisional; Region: PRK10884 386585010964 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 386585010965 Bacterial SH3 domain homologues; Region: SH3b; smart00287 386585010966 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 386585010967 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 386585010968 active site 386585010969 NTP binding site [chemical binding]; other site 386585010970 metal binding triad [ion binding]; metal-binding site 386585010971 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 386585010972 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 386585010973 Zn2+ binding site [ion binding]; other site 386585010974 Mg2+ binding site [ion binding]; other site 386585010975 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 386585010976 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 386585010977 homooctamer interface [polypeptide binding]; other site 386585010978 active site 386585010979 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 386585010980 transcriptional activator TtdR; Provisional; Region: PRK09801 386585010981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585010982 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 386585010983 putative effector binding pocket; other site 386585010984 putative dimerization interface [polypeptide binding]; other site 386585010985 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 386585010986 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 386585010987 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 386585010988 anion transporter; Region: dass; TIGR00785 386585010989 transmembrane helices; other site 386585010990 UGMP family protein; Validated; Region: PRK09604 386585010991 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585010992 nucleotide binding site [chemical binding]; other site 386585010993 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 386585010994 DNA primase; Validated; Region: dnaG; PRK05667 386585010995 CHC2 zinc finger; Region: zf-CHC2; pfam01807 386585010996 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 386585010997 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 386585010998 active site 386585010999 metal binding site [ion binding]; metal-binding site 386585011000 interdomain interaction site; other site 386585011001 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 386585011002 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 386585011003 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 386585011004 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 386585011005 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 386585011006 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 386585011007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 386585011008 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 386585011009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 386585011010 DNA binding residues [nucleotide binding] 386585011011 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 386585011012 active site 386585011013 SUMO-1 interface [polypeptide binding]; other site 386585011014 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 386585011015 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 386585011016 FAD binding pocket [chemical binding]; other site 386585011017 FAD binding motif [chemical binding]; other site 386585011018 phosphate binding motif [ion binding]; other site 386585011019 NAD binding pocket [chemical binding]; other site 386585011020 Predicted transcriptional regulators [Transcription]; Region: COG1695 386585011021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585011022 PAS fold; Region: PAS_3; pfam08447 386585011023 putative active site [active] 386585011024 heme pocket [chemical binding]; other site 386585011025 HAMP domain; Region: HAMP; pfam00672 386585011026 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 386585011027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 386585011028 dimer interface [polypeptide binding]; other site 386585011029 putative CheW interface [polypeptide binding]; other site 386585011030 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585011031 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 386585011032 inhibitor-cofactor binding pocket; inhibition site 386585011033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585011034 catalytic residue [active] 386585011035 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 386585011036 dimer interface [polypeptide binding]; other site 386585011037 putative tRNA-binding site [nucleotide binding]; other site 386585011038 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 386585011039 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585011040 DNA binding site [nucleotide binding] 386585011041 domain linker motif; other site 386585011042 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 386585011043 putative dimerization interface [polypeptide binding]; other site 386585011044 putative ligand binding site [chemical binding]; other site 386585011045 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 386585011046 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 386585011047 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 386585011048 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 386585011049 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 386585011050 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 386585011051 inner membrane transporter YjeM; Provisional; Region: PRK15238 386585011052 alpha-glucosidase; Provisional; Region: PRK10137 386585011053 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 386585011054 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 386585011055 active site 386585011056 FMN binding site [chemical binding]; other site 386585011057 2,4-decadienoyl-CoA binding site; other site 386585011058 catalytic residue [active] 386585011059 4Fe-4S cluster binding site [ion binding]; other site 386585011060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585011061 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 386585011062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585011063 non-specific DNA binding site [nucleotide binding]; other site 386585011064 salt bridge; other site 386585011065 sequence-specific DNA binding site [nucleotide binding]; other site 386585011066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 386585011067 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 386585011068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585011069 S-adenosylmethionine binding site [chemical binding]; other site 386585011070 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 386585011071 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 386585011072 putative active site [active] 386585011073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 386585011074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 386585011075 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 386585011076 serine/threonine transporter SstT; Provisional; Region: PRK13628 386585011077 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 386585011078 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 386585011079 galactarate dehydratase; Region: galactar-dH20; TIGR03248 386585011080 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 386585011081 glucuronate isomerase; Reviewed; Region: PRK02925 386585011082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585011083 D-galactonate transporter; Region: 2A0114; TIGR00893 386585011084 putative substrate translocation pore; other site 386585011085 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 386585011086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585011087 DNA-binding site [nucleotide binding]; DNA binding site 386585011088 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585011089 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 386585011090 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 386585011091 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 386585011092 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 386585011093 Predicted membrane protein [Function unknown]; Region: COG5393 386585011094 YqjK-like protein; Region: YqjK; pfam13997 386585011095 Predicted membrane protein [Function unknown]; Region: COG2259 386585011096 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 386585011097 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 386585011098 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 386585011099 putative dimer interface [polypeptide binding]; other site 386585011100 N-terminal domain interface [polypeptide binding]; other site 386585011101 putative substrate binding pocket (H-site) [chemical binding]; other site 386585011102 Predicted membrane protein [Function unknown]; Region: COG3152 386585011103 Predicted membrane protein [Function unknown]; Region: COG3152 386585011104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585011105 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 386585011106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585011107 dimerization interface [polypeptide binding]; other site 386585011108 Pirin-related protein [General function prediction only]; Region: COG1741 386585011109 Pirin; Region: Pirin; pfam02678 386585011110 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 386585011111 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585011112 serine transporter; Region: stp; TIGR00814 386585011113 L-serine dehydratase TdcG; Provisional; Region: PRK15040 386585011114 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 386585011115 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 386585011116 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 386585011117 homotrimer interaction site [polypeptide binding]; other site 386585011118 putative active site [active] 386585011119 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 386585011120 Pyruvate formate lyase 1; Region: PFL1; cd01678 386585011121 coenzyme A binding site [chemical binding]; other site 386585011122 active site 386585011123 catalytic residues [active] 386585011124 glycine loop; other site 386585011125 propionate/acetate kinase; Provisional; Region: PRK12379 386585011126 threonine/serine transporter TdcC; Provisional; Region: PRK13629 386585011127 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585011128 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 386585011129 tetramer interface [polypeptide binding]; other site 386585011130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585011131 catalytic residue [active] 386585011132 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 386585011133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585011134 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 386585011135 putative substrate binding pocket [chemical binding]; other site 386585011136 putative dimerization interface [polypeptide binding]; other site 386585011137 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 386585011138 hypothetical protein; Provisional; Region: PRK09716 386585011139 glycerate kinase I; Provisional; Region: PRK10342 386585011140 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 386585011141 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 386585011142 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 386585011143 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 386585011144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585011145 D-galactonate transporter; Region: 2A0114; TIGR00893 386585011146 putative substrate translocation pore; other site 386585011147 galactarate dehydratase; Region: galactar-dH20; TIGR03248 386585011148 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 386585011149 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 386585011150 putative regulator PrlF; Provisional; Region: PRK09974 386585011151 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 386585011152 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 386585011153 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 386585011154 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585011155 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 386585011156 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 386585011157 active site 386585011158 phosphorylation site [posttranslational modification] 386585011159 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 386585011160 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 386585011161 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 386585011162 active pocket/dimerization site; other site 386585011163 active site 386585011164 phosphorylation site [posttranslational modification] 386585011165 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 386585011166 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 386585011167 active site 386585011168 dimer interface [polypeptide binding]; other site 386585011169 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 386585011170 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 386585011171 dimer interface [polypeptide binding]; other site 386585011172 active site 386585011173 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 386585011174 putative active site [active] 386585011175 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 386585011176 active site 386585011177 intersubunit interface [polypeptide binding]; other site 386585011178 zinc binding site [ion binding]; other site 386585011179 Na+ binding site [ion binding]; other site 386585011180 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 386585011181 active site 386585011182 phosphorylation site [posttranslational modification] 386585011183 similar to PTS system, galactosamine IIC component AGAC_ECOLI (strain C) dad|AF228498-11|AAF81091.1, AGAC_ECOLI (K-12) gi|1789528 386585011184 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 386585011185 similar to galactosamine-6-phosphate isomerase AGAI_ECOLI (strain C) dad|AF228498-13|AAF81093.1, AGAI_ECOLI (K-12) gi|1789530 386585011186 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585011187 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 386585011188 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585011189 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585011190 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 386585011191 PapC N-terminal domain; Region: PapC_N; pfam13954 386585011192 Outer membrane usher protein; Region: Usher; pfam00577 386585011193 PapC C-terminal domain; Region: PapC_C; pfam13953 386585011194 Transposase; Region: HTH_Tnp_1; cl17663 386585011195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585011196 putative transposase OrfB; Reviewed; Region: PHA02517 386585011197 HTH-like domain; Region: HTH_21; pfam13276 386585011198 Integrase core domain; Region: rve; pfam00665 386585011199 Integrase core domain; Region: rve_3; pfam13683 386585011200 Fimbrial protein; Region: Fimbrial; pfam00419 386585011201 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 386585011202 putative SAM binding site [chemical binding]; other site 386585011203 putative homodimer interface [polypeptide binding]; other site 386585011204 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 386585011205 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 386585011206 putative ligand binding site [chemical binding]; other site 386585011207 TIGR00252 family protein; Region: TIGR00252 386585011208 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 386585011209 dimer interface [polypeptide binding]; other site 386585011210 active site 386585011211 outer membrane lipoprotein; Provisional; Region: PRK11023 386585011212 BON domain; Region: BON; pfam04972 386585011213 BON domain; Region: BON; pfam04972 386585011214 Predicted permease; Region: DUF318; pfam03773 386585011215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585011216 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 386585011217 NAD(P) binding site [chemical binding]; other site 386585011218 active site 386585011219 intracellular protease, PfpI family; Region: PfpI; TIGR01382 386585011220 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 386585011221 proposed catalytic triad [active] 386585011222 conserved cys residue [active] 386585011223 hypothetical protein; Provisional; Region: PRK03467 386585011224 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 386585011225 GIY-YIG motif/motif A; other site 386585011226 putative active site [active] 386585011227 putative metal binding site [ion binding]; other site 386585011228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 386585011229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585011230 Coenzyme A binding pocket [chemical binding]; other site 386585011231 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 386585011232 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 386585011233 putative protease; Provisional; Region: PRK15447 386585011234 hypothetical protein; Provisional; Region: PRK10508 386585011235 tryptophan permease; Provisional; Region: PRK10483 386585011236 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585011237 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 386585011238 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 386585011239 ATP binding site [chemical binding]; other site 386585011240 Mg++ binding site [ion binding]; other site 386585011241 motif III; other site 386585011242 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585011243 nucleotide binding region [chemical binding]; other site 386585011244 ATP-binding site [chemical binding]; other site 386585011245 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 386585011246 putative RNA binding site [nucleotide binding]; other site 386585011247 lipoprotein NlpI; Provisional; Region: PRK11189 386585011248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585011249 binding surface 386585011250 TPR motif; other site 386585011251 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 386585011252 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 386585011253 RNase E interface [polypeptide binding]; other site 386585011254 trimer interface [polypeptide binding]; other site 386585011255 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 386585011256 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 386585011257 RNase E interface [polypeptide binding]; other site 386585011258 trimer interface [polypeptide binding]; other site 386585011259 active site 386585011260 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 386585011261 putative nucleic acid binding region [nucleotide binding]; other site 386585011262 G-X-X-G motif; other site 386585011263 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 386585011264 RNA binding site [nucleotide binding]; other site 386585011265 domain interface; other site 386585011266 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 386585011267 16S/18S rRNA binding site [nucleotide binding]; other site 386585011268 S13e-L30e interaction site [polypeptide binding]; other site 386585011269 25S rRNA binding site [nucleotide binding]; other site 386585011270 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 386585011271 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 386585011272 RNA binding site [nucleotide binding]; other site 386585011273 active site 386585011274 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 386585011275 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 386585011276 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 386585011277 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 386585011278 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 386585011279 translation initiation factor IF-2; Validated; Region: infB; PRK05306 386585011280 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 386585011281 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 386585011282 G1 box; other site 386585011283 putative GEF interaction site [polypeptide binding]; other site 386585011284 GTP/Mg2+ binding site [chemical binding]; other site 386585011285 Switch I region; other site 386585011286 G2 box; other site 386585011287 G3 box; other site 386585011288 Switch II region; other site 386585011289 G4 box; other site 386585011290 G5 box; other site 386585011291 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 386585011292 Translation-initiation factor 2; Region: IF-2; pfam11987 386585011293 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 386585011294 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 386585011295 NusA N-terminal domain; Region: NusA_N; pfam08529 386585011296 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 386585011297 RNA binding site [nucleotide binding]; other site 386585011298 homodimer interface [polypeptide binding]; other site 386585011299 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 386585011300 G-X-X-G motif; other site 386585011301 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 386585011302 G-X-X-G motif; other site 386585011303 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 386585011304 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 386585011305 hypothetical protein; Provisional; Region: PRK14641 386585011306 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 386585011307 putative oligomer interface [polypeptide binding]; other site 386585011308 putative RNA binding site [nucleotide binding]; other site 386585011309 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 386585011310 ANP binding site [chemical binding]; other site 386585011311 Substrate Binding Site II [chemical binding]; other site 386585011312 Substrate Binding Site I [chemical binding]; other site 386585011313 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 386585011314 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 386585011315 Sulfatase; Region: Sulfatase; pfam00884 386585011316 Preprotein translocase SecG subunit; Region: SecG; pfam03840 386585011317 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 386585011318 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 386585011319 active site 386585011320 substrate binding site [chemical binding]; other site 386585011321 metal binding site [ion binding]; metal-binding site 386585011322 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 386585011323 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 386585011324 substrate binding pocket [chemical binding]; other site 386585011325 dimer interface [polypeptide binding]; other site 386585011326 inhibitor binding site; inhibition site 386585011327 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 386585011328 FtsH Extracellular; Region: FtsH_ext; pfam06480 386585011329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585011330 Walker A motif; other site 386585011331 ATP binding site [chemical binding]; other site 386585011332 Walker B motif; other site 386585011333 arginine finger; other site 386585011334 Peptidase family M41; Region: Peptidase_M41; pfam01434 386585011335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585011336 S-adenosylmethionine binding site [chemical binding]; other site 386585011337 RNA-binding protein YhbY; Provisional; Region: PRK10343 386585011338 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 386585011339 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 386585011340 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 386585011341 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 386585011342 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 386585011343 GTPase CgtA; Reviewed; Region: obgE; PRK12298 386585011344 GTP1/OBG; Region: GTP1_OBG; pfam01018 386585011345 Obg GTPase; Region: Obg; cd01898 386585011346 G1 box; other site 386585011347 GTP/Mg2+ binding site [chemical binding]; other site 386585011348 Switch I region; other site 386585011349 G2 box; other site 386585011350 G3 box; other site 386585011351 Switch II region; other site 386585011352 G4 box; other site 386585011353 G5 box; other site 386585011354 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 386585011355 EamA-like transporter family; Region: EamA; pfam00892 386585011356 EamA-like transporter family; Region: EamA; pfam00892 386585011357 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 386585011358 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 386585011359 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 386585011360 substrate binding pocket [chemical binding]; other site 386585011361 chain length determination region; other site 386585011362 substrate-Mg2+ binding site; other site 386585011363 catalytic residues [active] 386585011364 aspartate-rich region 1; other site 386585011365 active site lid residues [active] 386585011366 aspartate-rich region 2; other site 386585011367 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 386585011368 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 386585011369 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 386585011370 hinge; other site 386585011371 active site 386585011372 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 386585011373 Predicted NTP binding protein (contains STAS domain) [General function prediction only]; Region: COG3113 386585011374 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 386585011375 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 386585011376 mce related protein; Region: MCE; pfam02470 386585011377 conserved hypothetical integral membrane protein; Region: TIGR00056 386585011378 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 386585011379 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 386585011380 Walker A/P-loop; other site 386585011381 ATP binding site [chemical binding]; other site 386585011382 Q-loop/lid; other site 386585011383 ABC transporter signature motif; other site 386585011384 Walker B; other site 386585011385 D-loop; other site 386585011386 H-loop/switch region; other site 386585011387 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 386585011388 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 386585011389 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 386585011390 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 386585011391 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 386585011392 putative active site [active] 386585011393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 386585011394 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 386585011395 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 386585011396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 386585011397 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 386585011398 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 386585011399 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 386585011400 Walker A/P-loop; other site 386585011401 ATP binding site [chemical binding]; other site 386585011402 Q-loop/lid; other site 386585011403 ABC transporter signature motif; other site 386585011404 Walker B; other site 386585011405 D-loop; other site 386585011406 H-loop/switch region; other site 386585011407 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 386585011408 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 386585011409 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 386585011410 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 386585011411 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 386585011412 30S subunit binding site; other site 386585011413 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585011414 active site 386585011415 phosphorylation site [posttranslational modification] 386585011416 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 386585011417 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 386585011418 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585011419 dimerization domain swap beta strand [polypeptide binding]; other site 386585011420 regulatory protein interface [polypeptide binding]; other site 386585011421 active site 386585011422 regulatory phosphorylation site [posttranslational modification]; other site 386585011423 hypothetical protein; Provisional; Region: PRK10345 386585011424 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 386585011425 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 386585011426 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 386585011427 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 386585011428 conserved cys residue [active] 386585011429 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 386585011430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585011431 putative active site [active] 386585011432 heme pocket [chemical binding]; other site 386585011433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585011434 dimer interface [polypeptide binding]; other site 386585011435 phosphorylation site [posttranslational modification] 386585011436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585011437 ATP binding site [chemical binding]; other site 386585011438 Mg2+ binding site [ion binding]; other site 386585011439 G-X-G motif; other site 386585011440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585011441 active site 386585011442 phosphorylation site [posttranslational modification] 386585011443 intermolecular recognition site; other site 386585011444 dimerization interface [polypeptide binding]; other site 386585011445 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 386585011446 putative binding surface; other site 386585011447 active site 386585011448 radical SAM protein, TIGR01212 family; Region: TIGR01212 386585011449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585011450 FeS/SAM binding site; other site 386585011451 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 386585011452 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 386585011453 active site 386585011454 dimer interface [polypeptide binding]; other site 386585011455 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 386585011456 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 386585011457 active site 386585011458 FMN binding site [chemical binding]; other site 386585011459 substrate binding site [chemical binding]; other site 386585011460 3Fe-4S cluster binding site [ion binding]; other site 386585011461 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 386585011462 domain interface; other site 386585011463 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 386585011464 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 386585011465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585011466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585011467 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 386585011468 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 386585011469 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 386585011470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 386585011471 nucleotide binding site [chemical binding]; other site 386585011472 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 386585011473 putative active site cavity [active] 386585011474 putative sialic acid transporter; Provisional; Region: PRK03893 386585011475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585011476 putative substrate translocation pore; other site 386585011477 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 386585011478 inhibitor site; inhibition site 386585011479 active site 386585011480 dimer interface [polypeptide binding]; other site 386585011481 catalytic residue [active] 386585011482 transcriptional regulator NanR; Provisional; Region: PRK03837 386585011483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585011484 DNA-binding site [nucleotide binding]; DNA binding site 386585011485 FCD domain; Region: FCD; pfam07729 386585011486 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 386585011487 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 386585011488 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 386585011489 stringent starvation protein A; Provisional; Region: sspA; PRK09481 386585011490 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 386585011491 C-terminal domain interface [polypeptide binding]; other site 386585011492 putative GSH binding site (G-site) [chemical binding]; other site 386585011493 dimer interface [polypeptide binding]; other site 386585011494 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 386585011495 dimer interface [polypeptide binding]; other site 386585011496 N-terminal domain interface [polypeptide binding]; other site 386585011497 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 386585011498 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 386585011499 23S rRNA interface [nucleotide binding]; other site 386585011500 L3 interface [polypeptide binding]; other site 386585011501 Predicted ATPase [General function prediction only]; Region: COG1485 386585011502 hypothetical protein; Provisional; Region: PRK11677 386585011503 serine endoprotease; Provisional; Region: PRK10139 386585011504 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 386585011505 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 386585011506 protein binding site [polypeptide binding]; other site 386585011507 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 386585011508 serine endoprotease; Provisional; Region: PRK10898 386585011509 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 386585011510 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 386585011511 protein binding site [polypeptide binding]; other site 386585011512 malate dehydrogenase; Provisional; Region: PRK05086 386585011513 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 386585011514 NAD binding site [chemical binding]; other site 386585011515 dimerization interface [polypeptide binding]; other site 386585011516 Substrate binding site [chemical binding]; other site 386585011517 arginine repressor; Provisional; Region: PRK05066 386585011518 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 386585011519 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 386585011520 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585011521 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 386585011522 RNAase interaction site [polypeptide binding]; other site 386585011523 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 386585011524 Fusaric acid resistance protein family; Region: FUSC; pfam04632 386585011525 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 386585011526 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585011527 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585011528 efflux system membrane protein; Provisional; Region: PRK11594 386585011529 transcriptional regulator; Provisional; Region: PRK10632 386585011530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585011531 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 386585011532 putative effector binding pocket; other site 386585011533 dimerization interface [polypeptide binding]; other site 386585011534 protease TldD; Provisional; Region: tldD; PRK10735 386585011535 hypothetical protein; Provisional; Region: PRK10899 386585011536 Protein of unknown function; Region: DUF3971; pfam13116 386585011537 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 386585011538 ribonuclease G; Provisional; Region: PRK11712 386585011539 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 386585011540 homodimer interface [polypeptide binding]; other site 386585011541 oligonucleotide binding site [chemical binding]; other site 386585011542 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 386585011543 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 386585011544 active site 386585011545 dimer interface [polypeptide binding]; other site 386585011546 rod shape-determining protein MreD; Provisional; Region: PRK11060 386585011547 rod shape-determining protein MreC; Region: mreC; TIGR00219 386585011548 rod shape-determining protein MreB; Provisional; Region: PRK13927 386585011549 MreB and similar proteins; Region: MreB_like; cd10225 386585011550 nucleotide binding site [chemical binding]; other site 386585011551 Mg binding site [ion binding]; other site 386585011552 putative protofilament interaction site [polypeptide binding]; other site 386585011553 RodZ interaction site [polypeptide binding]; other site 386585011554 regulatory protein CsrD; Provisional; Region: PRK11059 386585011555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 386585011556 metal binding site [ion binding]; metal-binding site 386585011557 active site 386585011558 I-site; other site 386585011559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585011560 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 386585011561 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 386585011562 NADP binding site [chemical binding]; other site 386585011563 dimer interface [polypeptide binding]; other site 386585011564 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 386585011565 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 386585011566 carboxyltransferase (CT) interaction site; other site 386585011567 biotinylation site [posttranslational modification]; other site 386585011568 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 386585011569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 386585011570 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 386585011571 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 386585011572 hypothetical protein; Provisional; Region: PRK10633 386585011573 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 386585011574 Na binding site [ion binding]; other site 386585011575 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 386585011576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585011577 S-adenosylmethionine binding site [chemical binding]; other site 386585011578 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 386585011579 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 386585011580 FMN binding site [chemical binding]; other site 386585011581 active site 386585011582 catalytic residues [active] 386585011583 substrate binding site [chemical binding]; other site 386585011584 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 386585011585 putative methyltransferase; Provisional; Region: PRK11524 386585011586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585011587 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 386585011588 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 386585011589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585011590 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 386585011591 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 386585011592 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585011593 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585011594 similar to integral transmembrane protein ACRF_ECOLI gi|1789666; disrupted by frameshift 386585011595 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 386585011596 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585011597 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 386585011598 substrate binding pocket [chemical binding]; other site 386585011599 membrane-bound complex binding site; other site 386585011600 hinge residues; other site 386585011601 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 386585011602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 386585011603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585011604 dimer interface [polypeptide binding]; other site 386585011605 conserved gate region; other site 386585011606 putative PBP binding loops; other site 386585011607 ABC-ATPase subunit interface; other site 386585011608 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 386585011609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585011610 dimer interface [polypeptide binding]; other site 386585011611 conserved gate region; other site 386585011612 putative PBP binding loops; other site 386585011613 ABC-ATPase subunit interface; other site 386585011614 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 386585011615 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 386585011616 Walker A/P-loop; other site 386585011617 ATP binding site [chemical binding]; other site 386585011618 Q-loop/lid; other site 386585011619 ABC transporter signature motif; other site 386585011620 Walker B; other site 386585011621 D-loop; other site 386585011622 H-loop/switch region; other site 386585011623 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 386585011624 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 386585011625 trimer interface [polypeptide binding]; other site 386585011626 putative metal binding site [ion binding]; other site 386585011627 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 386585011628 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 386585011629 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 386585011630 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 386585011631 shikimate binding site; other site 386585011632 NAD(P) binding site [chemical binding]; other site 386585011633 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 386585011634 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 386585011635 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 386585011636 hypothetical protein; Validated; Region: PRK03430 386585011637 hypothetical protein; Provisional; Region: PRK10736 386585011638 DNA protecting protein DprA; Region: dprA; TIGR00732 386585011639 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 386585011640 active site 386585011641 catalytic residues [active] 386585011642 metal binding site [ion binding]; metal-binding site 386585011643 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 386585011644 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 386585011645 putative active site [active] 386585011646 substrate binding site [chemical binding]; other site 386585011647 putative cosubstrate binding site; other site 386585011648 catalytic site [active] 386585011649 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 386585011650 substrate binding site [chemical binding]; other site 386585011651 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 386585011652 putative RNA binding site [nucleotide binding]; other site 386585011653 16S rRNA methyltransferase B; Provisional; Region: PRK10901 386585011654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585011655 S-adenosylmethionine binding site [chemical binding]; other site 386585011656 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 386585011657 TrkA-N domain; Region: TrkA_N; pfam02254 386585011658 TrkA-C domain; Region: TrkA_C; pfam02080 386585011659 TrkA-N domain; Region: TrkA_N; pfam02254 386585011660 TrkA-C domain; Region: TrkA_C; pfam02080 386585011661 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 386585011662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 386585011663 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 386585011664 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 386585011665 DNA binding residues [nucleotide binding] 386585011666 dimer interface [polypeptide binding]; other site 386585011667 metal binding site [ion binding]; metal-binding site 386585011668 hypothetical protein; Provisional; Region: PRK10203 386585011669 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 386585011670 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 386585011671 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 386585011672 alphaNTD homodimer interface [polypeptide binding]; other site 386585011673 alphaNTD - beta interaction site [polypeptide binding]; other site 386585011674 alphaNTD - beta' interaction site [polypeptide binding]; other site 386585011675 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 386585011676 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 386585011677 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 386585011678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585011679 RNA binding surface [nucleotide binding]; other site 386585011680 30S ribosomal protein S11; Validated; Region: PRK05309 386585011681 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 386585011682 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 386585011683 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 386585011684 SecY translocase; Region: SecY; pfam00344 386585011685 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 386585011686 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 386585011687 23S rRNA binding site [nucleotide binding]; other site 386585011688 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 386585011689 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 386585011690 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 386585011691 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 386585011692 23S rRNA interface [nucleotide binding]; other site 386585011693 5S rRNA interface [nucleotide binding]; other site 386585011694 L27 interface [polypeptide binding]; other site 386585011695 L5 interface [polypeptide binding]; other site 386585011696 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 386585011697 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 386585011698 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 386585011699 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 386585011700 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 386585011701 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 386585011702 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 386585011703 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 386585011704 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 386585011705 RNA binding site [nucleotide binding]; other site 386585011706 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 386585011707 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 386585011708 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 386585011709 23S rRNA interface [nucleotide binding]; other site 386585011710 putative translocon interaction site; other site 386585011711 signal recognition particle (SRP54) interaction site; other site 386585011712 L23 interface [polypeptide binding]; other site 386585011713 trigger factor interaction site; other site 386585011714 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 386585011715 23S rRNA interface [nucleotide binding]; other site 386585011716 5S rRNA interface [nucleotide binding]; other site 386585011717 putative antibiotic binding site [chemical binding]; other site 386585011718 L25 interface [polypeptide binding]; other site 386585011719 L27 interface [polypeptide binding]; other site 386585011720 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 386585011721 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 386585011722 G-X-X-G motif; other site 386585011723 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 386585011724 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 386585011725 protein-rRNA interface [nucleotide binding]; other site 386585011726 putative translocon binding site; other site 386585011727 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 386585011728 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 386585011729 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 386585011730 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 386585011731 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 386585011732 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 386585011733 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 386585011734 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 386585011735 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 386585011736 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 386585011737 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 386585011738 Ferritin-like domain; Region: Ferritin; pfam00210 386585011739 heme binding site [chemical binding]; other site 386585011740 ferroxidase pore; other site 386585011741 ferroxidase diiron center [ion binding]; other site 386585011742 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 386585011743 elongation factor Tu; Reviewed; Region: PRK00049 386585011744 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 386585011745 G1 box; other site 386585011746 GEF interaction site [polypeptide binding]; other site 386585011747 GTP/Mg2+ binding site [chemical binding]; other site 386585011748 Switch I region; other site 386585011749 G2 box; other site 386585011750 G3 box; other site 386585011751 Switch II region; other site 386585011752 G4 box; other site 386585011753 G5 box; other site 386585011754 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 386585011755 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 386585011756 Antibiotic Binding Site [chemical binding]; other site 386585011757 elongation factor G; Reviewed; Region: PRK00007 386585011758 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 386585011759 G1 box; other site 386585011760 putative GEF interaction site [polypeptide binding]; other site 386585011761 GTP/Mg2+ binding site [chemical binding]; other site 386585011762 Switch I region; other site 386585011763 G2 box; other site 386585011764 G3 box; other site 386585011765 Switch II region; other site 386585011766 G4 box; other site 386585011767 G5 box; other site 386585011768 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 386585011769 Elongation Factor G, domain II; Region: EFG_II; pfam14492 386585011770 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 386585011771 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 386585011772 30S ribosomal protein S7; Validated; Region: PRK05302 386585011773 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 386585011774 S17 interaction site [polypeptide binding]; other site 386585011775 S8 interaction site; other site 386585011776 16S rRNA interaction site [nucleotide binding]; other site 386585011777 streptomycin interaction site [chemical binding]; other site 386585011778 23S rRNA interaction site [nucleotide binding]; other site 386585011779 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 386585011780 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 386585011781 sulfur relay protein TusC; Validated; Region: PRK00211 386585011782 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 386585011783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 386585011784 YheO-like PAS domain; Region: PAS_6; pfam08348 386585011785 HTH domain; Region: HTH_22; pfam13309 386585011786 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 386585011787 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 386585011788 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 386585011789 phi X174 lysis protein; Provisional; Region: PRK02793 386585011790 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 386585011791 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 386585011792 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 386585011793 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 386585011794 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 386585011795 TrkA-N domain; Region: TrkA_N; pfam02254 386585011796 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 386585011797 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 386585011798 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585011799 ABC transporter; Region: ABC_tran_2; pfam12848 386585011800 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585011801 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 386585011802 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 386585011803 putative hydrolase; Provisional; Region: PRK10985 386585011804 hypothetical protein; Provisional; Region: PRK04966 386585011805 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 386585011806 active site 386585011807 hypothetical protein; Provisional; Region: PRK10738 386585011808 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 386585011809 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 386585011810 ligand binding site [chemical binding]; other site 386585011811 flexible hinge region; other site 386585011812 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 386585011813 putative switch regulator; other site 386585011814 non-specific DNA interactions [nucleotide binding]; other site 386585011815 DNA binding site [nucleotide binding] 386585011816 sequence specific DNA binding site [nucleotide binding]; other site 386585011817 putative cAMP binding site [chemical binding]; other site 386585011818 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 386585011819 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 386585011820 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 386585011821 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 386585011822 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 386585011823 inhibitor-cofactor binding pocket; inhibition site 386585011824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585011825 catalytic residue [active] 386585011826 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 386585011827 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 386585011828 glutamine binding [chemical binding]; other site 386585011829 catalytic triad [active] 386585011830 cell filamentation protein Fic; Provisional; Region: PRK10347 386585011831 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 386585011832 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 386585011833 substrate binding site [chemical binding]; other site 386585011834 putative transporter; Provisional; Region: PRK03699 386585011835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585011836 putative substrate translocation pore; other site 386585011837 nitrite reductase subunit NirD; Provisional; Region: PRK14989 386585011838 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 386585011839 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 386585011840 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 386585011841 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 386585011842 nitrite transporter NirC; Provisional; Region: PRK11562 386585011843 siroheme synthase; Provisional; Region: cysG; PRK10637 386585011844 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 386585011845 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 386585011846 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 386585011847 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 386585011848 active site 386585011849 SAM binding site [chemical binding]; other site 386585011850 homodimer interface [polypeptide binding]; other site 386585011851 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 386585011852 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 386585011853 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585011854 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 386585011855 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 386585011856 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 386585011857 dimer interface [polypeptide binding]; other site 386585011858 active site 386585011859 fructoselysine 3-epimerase; Provisional; Region: PRK09856 386585011860 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 386585011861 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 386585011862 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 386585011863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585011864 DNA-binding site [nucleotide binding]; DNA binding site 386585011865 UTRA domain; Region: UTRA; pfam07702 386585011866 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 386585011867 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 386585011868 active site 386585011869 HIGH motif; other site 386585011870 dimer interface [polypeptide binding]; other site 386585011871 KMSKS motif; other site 386585011872 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585011873 phosphoglycolate phosphatase; Provisional; Region: PRK13222 386585011874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585011875 motif II; other site 386585011876 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 386585011877 substrate binding site [chemical binding]; other site 386585011878 hexamer interface [polypeptide binding]; other site 386585011879 metal binding site [ion binding]; metal-binding site 386585011880 DNA adenine methylase; Provisional; Region: PRK10904 386585011881 cell division protein DamX; Validated; Region: PRK10905 386585011882 Sporulation related domain; Region: SPOR; pfam05036 386585011883 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 386585011884 active site 386585011885 dimer interface [polypeptide binding]; other site 386585011886 metal binding site [ion binding]; metal-binding site 386585011887 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 386585011888 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 386585011889 ADP binding site [chemical binding]; other site 386585011890 magnesium binding site [ion binding]; other site 386585011891 putative shikimate binding site; other site 386585011892 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 386585011893 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 386585011894 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 386585011895 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 386585011896 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 386585011897 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 386585011898 Transglycosylase; Region: Transgly; pfam00912 386585011899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 386585011900 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 386585011901 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 386585011902 ADP-ribose binding site [chemical binding]; other site 386585011903 dimer interface [polypeptide binding]; other site 386585011904 active site 386585011905 nudix motif; other site 386585011906 metal binding site [ion binding]; metal-binding site 386585011907 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 386585011908 GMP/IMP nucleotidase; Provisional; Region: PRK14988 386585011909 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 386585011910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585011911 motif II; other site 386585011912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585011913 RNA binding surface [nucleotide binding]; other site 386585011914 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 386585011915 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 386585011916 dimerization interface [polypeptide binding]; other site 386585011917 domain crossover interface; other site 386585011918 redox-dependent activation switch; other site 386585011919 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 386585011920 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 386585011921 active site 386585011922 substrate-binding site [chemical binding]; other site 386585011923 metal-binding site [ion binding] 386585011924 ATP binding site [chemical binding]; other site 386585011925 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 386585011926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585011927 dimerization interface [polypeptide binding]; other site 386585011928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585011929 dimer interface [polypeptide binding]; other site 386585011930 phosphorylation site [posttranslational modification] 386585011931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585011932 ATP binding site [chemical binding]; other site 386585011933 Mg2+ binding site [ion binding]; other site 386585011934 G-X-G motif; other site 386585011935 osmolarity response regulator; Provisional; Region: ompR; PRK09468 386585011936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585011937 active site 386585011938 phosphorylation site [posttranslational modification] 386585011939 intermolecular recognition site; other site 386585011940 dimerization interface [polypeptide binding]; other site 386585011941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585011942 DNA binding site [nucleotide binding] 386585011943 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 386585011944 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 386585011945 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 386585011946 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 386585011947 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 386585011948 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 386585011949 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 386585011950 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 386585011951 RNA binding site [nucleotide binding]; other site 386585011952 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 386585011953 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 386585011954 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 386585011955 G1 box; other site 386585011956 GTP/Mg2+ binding site [chemical binding]; other site 386585011957 Switch I region; other site 386585011958 G2 box; other site 386585011959 G3 box; other site 386585011960 Switch II region; other site 386585011961 G4 box; other site 386585011962 G5 box; other site 386585011963 Nucleoside recognition; Region: Gate; pfam07670 386585011964 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 386585011965 Nucleoside recognition; Region: Gate; pfam07670 386585011966 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 386585011967 putative transposase; Provisional; Region: PRK09857 386585011968 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 386585011969 carboxylesterase BioH; Provisional; Region: PRK10349 386585011970 Putative lysophospholipase; Region: Hydrolase_4; cl19140 386585011971 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 386585011972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585011973 active site 386585011974 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 386585011975 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 386585011976 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 386585011977 high-affinity gluconate transporter; Provisional; Region: PRK14984 386585011978 GntP family permease; Region: GntP_permease; pfam02447 386585011979 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 386585011980 4-alpha-glucanotransferase; Region: malQ; TIGR00217 386585011981 maltodextrin phosphorylase; Provisional; Region: PRK14985 386585011982 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 386585011983 homodimer interface [polypeptide binding]; other site 386585011984 active site pocket [active] 386585011985 transcriptional regulator MalT; Provisional; Region: PRK04841 386585011986 AAA ATPase domain; Region: AAA_16; pfam13191 386585011987 Cohesin loading factor; Region: Cohesin_load; pfam10345 386585011988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585011989 DNA binding residues [nucleotide binding] 386585011990 dimerization interface [polypeptide binding]; other site 386585011991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 386585011992 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 386585011993 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 386585011994 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 386585011995 putative active site [active] 386585011996 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 386585011997 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 386585011998 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 386585011999 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 386585012000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585012001 Walker A motif; other site 386585012002 ATP binding site [chemical binding]; other site 386585012003 Walker B motif; other site 386585012004 arginine finger; other site 386585012005 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 386585012006 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 386585012007 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585012008 intramembrane serine protease GlpG; Provisional; Region: PRK10907 386585012009 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 386585012010 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 386585012011 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 386585012012 active site residue [active] 386585012013 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 386585012014 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 386585012015 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 386585012016 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 386585012017 glycogen phosphorylase; Provisional; Region: PRK14986 386585012018 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 386585012019 homodimer interface [polypeptide binding]; other site 386585012020 active site pocket [active] 386585012021 glycogen synthase; Provisional; Region: glgA; PRK00654 386585012022 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 386585012023 ADP-binding pocket [chemical binding]; other site 386585012024 homodimer interface [polypeptide binding]; other site 386585012025 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 386585012026 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 386585012027 ligand binding site; other site 386585012028 oligomer interface; other site 386585012029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 386585012030 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 386585012031 dimer interface [polypeptide binding]; other site 386585012032 N-terminal domain interface [polypeptide binding]; other site 386585012033 sulfate 1 binding site; other site 386585012034 glycogen debranching enzyme; Provisional; Region: PRK03705 386585012035 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 386585012036 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 386585012037 active site 386585012038 catalytic site [active] 386585012039 glycogen branching enzyme; Provisional; Region: PRK05402 386585012040 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 386585012041 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 386585012042 active site 386585012043 catalytic site [active] 386585012044 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 386585012045 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 386585012046 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 386585012047 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 386585012048 putative antibiotic transporter; Provisional; Region: PRK10739 386585012049 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 386585012050 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 386585012051 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 386585012052 non-specific DNA interactions [nucleotide binding]; other site 386585012053 DNA binding site [nucleotide binding] 386585012054 sequence specific DNA binding site [nucleotide binding]; other site 386585012055 putative cAMP binding site [chemical binding]; other site 386585012056 similar to ATP-dependent DNA helicase; disrupted by frameshift 386585012057 low affinity gluconate transporter; Provisional; Region: PRK10472 386585012058 GntP family permease; Region: GntP_permease; pfam02447 386585012059 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 386585012060 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 386585012061 ATP-binding site [chemical binding]; other site 386585012062 Gluconate-6-phosphate binding site [chemical binding]; other site 386585012063 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 386585012064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585012065 DNA binding site [nucleotide binding] 386585012066 domain linker motif; other site 386585012067 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 386585012068 putative ligand binding site [chemical binding]; other site 386585012069 putative dimerization interface [polypeptide binding]; other site 386585012070 Pirin-related protein [General function prediction only]; Region: COG1741 386585012071 Pirin; Region: Pirin; pfam02678 386585012072 putative oxidoreductase; Provisional; Region: PRK10206 386585012073 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 386585012074 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 386585012075 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 386585012076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585012077 Coenzyme A binding pocket [chemical binding]; other site 386585012078 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 386585012079 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 386585012080 hypothetical protein; Provisional; Region: PRK10350 386585012081 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 386585012082 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 386585012083 putative active site [active] 386585012084 catalytic site [active] 386585012085 putative metal binding site [ion binding]; other site 386585012086 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 386585012087 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 386585012088 Walker A/P-loop; other site 386585012089 ATP binding site [chemical binding]; other site 386585012090 Q-loop/lid; other site 386585012091 ABC transporter signature motif; other site 386585012092 Walker B; other site 386585012093 D-loop; other site 386585012094 H-loop/switch region; other site 386585012095 TOBE domain; Region: TOBE_2; pfam08402 386585012096 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 386585012097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585012098 dimer interface [polypeptide binding]; other site 386585012099 conserved gate region; other site 386585012100 putative PBP binding loops; other site 386585012101 ABC-ATPase subunit interface; other site 386585012102 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 386585012103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585012104 dimer interface [polypeptide binding]; other site 386585012105 conserved gate region; other site 386585012106 putative PBP binding loops; other site 386585012107 ABC-ATPase subunit interface; other site 386585012108 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 386585012109 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 386585012110 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 386585012111 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 386585012112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585012113 binding surface 386585012114 TPR motif; other site 386585012115 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 386585012116 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 386585012117 Walker A/P-loop; other site 386585012118 ATP binding site [chemical binding]; other site 386585012119 Q-loop/lid; other site 386585012120 ABC transporter signature motif; other site 386585012121 Walker B; other site 386585012122 D-loop; other site 386585012123 H-loop/switch region; other site 386585012124 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 386585012125 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 386585012126 Walker A/P-loop; other site 386585012127 ATP binding site [chemical binding]; other site 386585012128 Q-loop/lid; other site 386585012129 ABC transporter signature motif; other site 386585012130 Walker B; other site 386585012131 D-loop; other site 386585012132 H-loop/switch region; other site 386585012133 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 386585012134 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 386585012135 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 386585012136 TM-ABC transporter signature motif; other site 386585012137 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 386585012138 TM-ABC transporter signature motif; other site 386585012139 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 386585012140 dimerization interface [polypeptide binding]; other site 386585012141 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 386585012142 ligand binding site [chemical binding]; other site 386585012143 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 386585012144 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 386585012145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 386585012146 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 386585012147 dimerization interface [polypeptide binding]; other site 386585012148 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 386585012149 ligand binding site [chemical binding]; other site 386585012150 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 386585012151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 386585012152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 386585012153 DNA binding residues [nucleotide binding] 386585012154 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 386585012155 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 386585012156 cell division protein FtsE; Provisional; Region: PRK10908 386585012157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585012158 Walker A/P-loop; other site 386585012159 ATP binding site [chemical binding]; other site 386585012160 Q-loop/lid; other site 386585012161 ABC transporter signature motif; other site 386585012162 Walker B; other site 386585012163 D-loop; other site 386585012164 H-loop/switch region; other site 386585012165 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 386585012166 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 386585012167 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 386585012168 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 386585012169 P loop; other site 386585012170 GTP binding site [chemical binding]; other site 386585012171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585012172 S-adenosylmethionine binding site [chemical binding]; other site 386585012173 hypothetical protein; Provisional; Region: PRK10910 386585012174 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 386585012175 Predicted membrane protein [Function unknown]; Region: COG3714 386585012176 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 386585012177 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 386585012178 metal-binding site [ion binding] 386585012179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 386585012180 Soluble P-type ATPase [General function prediction only]; Region: COG4087 386585012181 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 386585012182 CPxP motif; other site 386585012183 hypothetical protein; Provisional; Region: PRK11212 386585012184 hypothetical protein; Provisional; Region: PRK11615 386585012185 major facilitator superfamily transporter; Provisional; Region: PRK05122 386585012186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585012187 putative substrate translocation pore; other site 386585012188 Domain of unknown function DUF20; Region: UPF0118; cl00465 386585012189 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 386585012190 O-methyltransferase; Region: Methyltransf_2; pfam00891 386585012191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585012192 S-adenosylmethionine binding site [chemical binding]; other site 386585012193 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 386585012194 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 386585012195 putative acyl-acceptor binding pocket; other site 386585012196 Phosphopantetheine attachment site; Region: PP-binding; cl09936 386585012197 acyl carrier protein; Provisional; Region: PRK05350 386585012198 Predicted membrane protein [Function unknown]; Region: COG4648 386585012199 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 386585012200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 386585012201 acyl-activating enzyme (AAE) consensus motif; other site 386585012202 active site 386585012203 AMP binding site [chemical binding]; other site 386585012204 CoA binding site [chemical binding]; other site 386585012205 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 386585012206 active site 2 [active] 386585012207 active site 1 [active] 386585012208 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 386585012209 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 386585012210 Ligand binding site; other site 386585012211 Putative Catalytic site; other site 386585012212 DXD motif; other site 386585012213 Predicted acyltransferase [General function prediction only]; Region: COG4261 386585012214 putative acyl-acceptor binding pocket; other site 386585012215 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 386585012216 active site 386585012217 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 386585012218 Predicted exporter [General function prediction only]; Region: COG4258 386585012219 MMPL family; Region: MMPL; cl14618 386585012220 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 386585012221 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 386585012222 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 386585012223 dimer interface [polypeptide binding]; other site 386585012224 active site 386585012225 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 386585012226 putative active site 1 [active] 386585012227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 386585012228 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 386585012229 NAD(P) binding site [chemical binding]; other site 386585012230 active site 386585012231 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 386585012232 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 386585012233 dimer interface [polypeptide binding]; other site 386585012234 active site 386585012235 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 386585012236 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 386585012237 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 386585012238 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 386585012239 substrate binding site [chemical binding]; other site 386585012240 nickel transporter permease NikB; Provisional; Region: PRK10352 386585012241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585012242 dimer interface [polypeptide binding]; other site 386585012243 conserved gate region; other site 386585012244 putative PBP binding loops; other site 386585012245 ABC-ATPase subunit interface; other site 386585012246 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 386585012247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585012248 dimer interface [polypeptide binding]; other site 386585012249 conserved gate region; other site 386585012250 putative PBP binding loops; other site 386585012251 ABC-ATPase subunit interface; other site 386585012252 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 386585012253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585012254 Walker A/P-loop; other site 386585012255 ATP binding site [chemical binding]; other site 386585012256 Q-loop/lid; other site 386585012257 ABC transporter signature motif; other site 386585012258 Walker B; other site 386585012259 D-loop; other site 386585012260 H-loop/switch region; other site 386585012261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585012262 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 386585012263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585012264 Walker A/P-loop; other site 386585012265 ATP binding site [chemical binding]; other site 386585012266 Q-loop/lid; other site 386585012267 ABC transporter signature motif; other site 386585012268 Walker B; other site 386585012269 D-loop; other site 386585012270 H-loop/switch region; other site 386585012271 nickel responsive regulator; Provisional; Region: PRK02967 386585012272 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 386585012273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 386585012274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585012275 DNA-binding site [nucleotide binding]; DNA binding site 386585012276 UTRA domain; Region: UTRA; pfam07702 386585012277 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585012278 active site 386585012279 phosphorylation site [posttranslational modification] 386585012280 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 386585012281 active site 386585012282 P-loop; other site 386585012283 phosphorylation site [posttranslational modification] 386585012284 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 386585012285 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 386585012286 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 386585012287 putative N- and C-terminal domain interface [polypeptide binding]; other site 386585012288 putative active site [active] 386585012289 putative MgATP binding site [chemical binding]; other site 386585012290 catalytic site [active] 386585012291 metal binding site [ion binding]; metal-binding site 386585012292 putative carbohydrate binding site [chemical binding]; other site 386585012293 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585012294 dimerization domain swap beta strand [polypeptide binding]; other site 386585012295 regulatory protein interface [polypeptide binding]; other site 386585012296 active site 386585012297 regulatory phosphorylation site [posttranslational modification]; other site 386585012298 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 386585012299 intersubunit interface [polypeptide binding]; other site 386585012300 active site 386585012301 zinc binding site [ion binding]; other site 386585012302 Na+ binding site [ion binding]; other site 386585012303 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 386585012304 HicB family; Region: HicB; pfam05534 386585012305 YcfA-like protein; Region: YcfA; pfam07927 386585012306 Structural glycoprotein p40/gp41 conserved region; Region: Baculo_gp41; pfam04700 386585012307 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 386585012308 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 386585012309 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 386585012310 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 386585012311 Walker A/P-loop; other site 386585012312 ATP binding site [chemical binding]; other site 386585012313 Q-loop/lid; other site 386585012314 ABC transporter signature motif; other site 386585012315 Walker B; other site 386585012316 D-loop; other site 386585012317 H-loop/switch region; other site 386585012318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585012319 Walker A/P-loop; other site 386585012320 ATP binding site [chemical binding]; other site 386585012321 Q-loop/lid; other site 386585012322 ABC transporter signature motif; other site 386585012323 Walker B; other site 386585012324 D-loop; other site 386585012325 H-loop/switch region; other site 386585012326 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 386585012327 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 386585012328 HlyD family secretion protein; Region: HlyD; pfam00529 386585012329 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585012330 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585012331 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 386585012332 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 386585012333 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 386585012334 Predicted flavoproteins [General function prediction only]; Region: COG2081 386585012335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585012336 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 386585012337 universal stress protein UspB; Provisional; Region: PRK04960 386585012338 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585012339 Ligand Binding Site [chemical binding]; other site 386585012340 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 386585012341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585012342 putative substrate translocation pore; other site 386585012343 putative methyltransferase; Provisional; Region: PRK10742 386585012344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585012345 S-adenosylmethionine binding site [chemical binding]; other site 386585012346 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 386585012347 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 386585012348 active site 386585012349 Zn binding site [ion binding]; other site 386585012350 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 386585012351 glutathione reductase; Validated; Region: PRK06116 386585012352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585012353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585012354 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 386585012355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585012356 dimerization interface [polypeptide binding]; other site 386585012357 putative DNA binding site [nucleotide binding]; other site 386585012358 putative Zn2+ binding site [ion binding]; other site 386585012359 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 386585012360 Citrate transporter; Region: CitMHS; pfam03600 386585012361 transmembrane helices; other site 386585012362 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 386585012363 catalytic residues [active] 386585012364 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 386585012365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585012366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585012367 DNA binding residues [nucleotide binding] 386585012368 dimerization interface [polypeptide binding]; other site 386585012369 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 386585012370 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 386585012371 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 386585012372 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 386585012373 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585012374 N-terminal plug; other site 386585012375 ligand-binding site [chemical binding]; other site 386585012376 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 386585012377 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 386585012378 putative hemin binding site; other site 386585012379 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 386585012380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585012381 FeS/SAM binding site; other site 386585012382 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 386585012383 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 386585012384 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 386585012385 NAD(P) binding site [chemical binding]; other site 386585012386 putative active site [active] 386585012387 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 386585012388 ABC-ATPase subunit interface; other site 386585012389 dimer interface [polypeptide binding]; other site 386585012390 putative PBP binding regions; other site 386585012391 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 386585012392 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 386585012393 Walker A/P-loop; other site 386585012394 ATP binding site [chemical binding]; other site 386585012395 Q-loop/lid; other site 386585012396 ABC transporter signature motif; other site 386585012397 Walker B; other site 386585012398 D-loop; other site 386585012399 H-loop/switch region; other site 386585012400 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 386585012401 MgtC family; Region: MgtC; pfam02308 386585012402 acid-resistance protein; Provisional; Region: hdeB; PRK11566 386585012403 acid-resistance protein; Provisional; Region: PRK10208 386585012404 acid-resistance membrane protein; Provisional; Region: PRK10209 386585012405 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 386585012406 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 386585012407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585012408 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585012409 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 386585012410 MMPL family; Region: MMPL; cl14618 386585012411 MMPL family; Region: MMPL; cl14618 386585012412 transcriptional regulator YdeO; Provisional; Region: PRK09940 386585012413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012415 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 386585012416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012418 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 386585012419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585012420 catalytic residue [active] 386585012421 Haem-binding domain; Region: Haem_bd; pfam14376 386585012422 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 386585012423 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 386585012424 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 386585012425 trehalase; Provisional; Region: treF; PRK13270 386585012426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585012427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585012428 DNA binding residues [nucleotide binding] 386585012429 dimerization interface [polypeptide binding]; other site 386585012430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585012431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585012432 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 386585012433 putative effector binding pocket; other site 386585012434 putative dimerization interface [polypeptide binding]; other site 386585012435 inner membrane protein YhjD; Region: TIGR00766 386585012436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585012437 metabolite-proton symporter; Region: 2A0106; TIGR00883 386585012438 putative substrate translocation pore; other site 386585012439 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 386585012440 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 386585012441 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585012442 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 386585012443 substrate binding site [chemical binding]; other site 386585012444 ATP binding site [chemical binding]; other site 386585012445 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 386585012446 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 386585012447 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 386585012448 putative diguanylate cyclase; Provisional; Region: PRK13561 386585012449 HAMP domain; Region: HAMP; pfam00672 386585012450 diguanylate cyclase; Region: GGDEF; smart00267 386585012451 metal binding site [ion binding]; metal-binding site 386585012452 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585012453 TPR repeat; Region: TPR_11; pfam13414 386585012454 Tetratricopeptide repeat; Region: TPR_20; pfam14561 386585012455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585012456 binding surface 386585012457 TPR motif; other site 386585012458 Tetratricopeptide repeat; Region: TPR_16; pfam13432 386585012459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585012460 binding surface 386585012461 TPR motif; other site 386585012462 Tetratricopeptide repeat; Region: TPR_16; pfam13432 386585012463 Tetratricopeptide repeat; Region: TPR_19; pfam14559 386585012464 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 386585012465 endo-1,4-D-glucanase; Provisional; Region: PRK11097 386585012466 cellulose synthase regulator protein; Provisional; Region: PRK11114 386585012467 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 386585012468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 386585012469 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 386585012470 DXD motif; other site 386585012471 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 386585012472 PilZ domain; Region: PilZ; pfam07238 386585012473 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585012474 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 386585012475 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 386585012476 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 386585012477 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 386585012478 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585012479 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 386585012480 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 386585012481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585012482 Walker A/P-loop; other site 386585012483 ATP binding site [chemical binding]; other site 386585012484 Q-loop/lid; other site 386585012485 ABC transporter signature motif; other site 386585012486 Walker B; other site 386585012487 D-loop; other site 386585012488 H-loop/switch region; other site 386585012489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585012490 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 386585012491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585012492 Walker A/P-loop; other site 386585012493 ATP binding site [chemical binding]; other site 386585012494 Q-loop/lid; other site 386585012495 ABC transporter signature motif; other site 386585012496 Walker B; other site 386585012497 D-loop; other site 386585012498 H-loop/switch region; other site 386585012499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585012500 dipeptide transporter; Provisional; Region: PRK10913 386585012501 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 386585012502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585012503 dimer interface [polypeptide binding]; other site 386585012504 conserved gate region; other site 386585012505 putative PBP binding loops; other site 386585012506 ABC-ATPase subunit interface; other site 386585012507 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 386585012508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585012509 dimer interface [polypeptide binding]; other site 386585012510 conserved gate region; other site 386585012511 putative PBP binding loops; other site 386585012512 ABC-ATPase subunit interface; other site 386585012513 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 386585012514 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 386585012515 peptide binding site [polypeptide binding]; other site 386585012516 phosphoethanolamine transferase; Provisional; Region: PRK11560 386585012517 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 386585012518 Sulfatase; Region: Sulfatase; pfam00884 386585012519 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 386585012520 Fimbrial protein; Region: Fimbrial; cl01416 386585012521 similar to outer membrane usher protein precursor; contains internal stop codons 386585012522 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 386585012523 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585012524 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585012525 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 386585012526 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 386585012527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585012528 putative substrate translocation pore; other site 386585012529 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 386585012530 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 386585012531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 386585012532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585012533 Coenzyme A binding pocket [chemical binding]; other site 386585012534 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 386585012535 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 386585012536 molybdopterin cofactor binding site [chemical binding]; other site 386585012537 substrate binding site [chemical binding]; other site 386585012538 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 386585012539 molybdopterin cofactor binding site; other site 386585012540 putative outer membrane lipoprotein; Provisional; Region: PRK10510 386585012541 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 386585012542 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585012543 ligand binding site [chemical binding]; other site 386585012544 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 386585012545 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 386585012546 dimerization interface [polypeptide binding]; other site 386585012547 ligand binding site [chemical binding]; other site 386585012548 NADP binding site [chemical binding]; other site 386585012549 catalytic site [active] 386585012550 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 386585012551 Predicted transcriptional regulator [Transcription]; Region: COG2944 386585012552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585012553 non-specific DNA binding site [nucleotide binding]; other site 386585012554 salt bridge; other site 386585012555 sequence-specific DNA binding site [nucleotide binding]; other site 386585012556 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 386585012557 DNA-binding site [nucleotide binding]; DNA binding site 386585012558 RNA-binding motif; other site 386585012559 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 386585012560 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 386585012561 DALR anticodon binding domain; Region: DALR_1; pfam05746 386585012562 anticodon binding site; other site 386585012563 tRNA binding surface [nucleotide binding]; other site 386585012564 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 386585012565 dimer interface [polypeptide binding]; other site 386585012566 motif 1; other site 386585012567 active site 386585012568 motif 2; other site 386585012569 motif 3; other site 386585012570 YsaB-like lipoprotein; Region: YsaB; pfam13983 386585012571 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 386585012572 hypothetical protein; Provisional; Region: PRK11383 386585012573 yiaA/B two helix domain; Region: YiaAB; pfam05360 386585012574 yiaA/B two helix domain; Region: YiaAB; pfam05360 386585012575 hypothetical protein; Provisional; Region: PRK11403 386585012576 yiaA/B two helix domain; Region: YiaAB; pfam05360 386585012577 xylulokinase; Provisional; Region: PRK15027 386585012578 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 386585012579 N- and C-terminal domain interface [polypeptide binding]; other site 386585012580 active site 386585012581 MgATP binding site [chemical binding]; other site 386585012582 catalytic site [active] 386585012583 metal binding site [ion binding]; metal-binding site 386585012584 xylulose binding site [chemical binding]; other site 386585012585 homodimer interface [polypeptide binding]; other site 386585012586 xylose isomerase; Provisional; Region: PRK05474 386585012587 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 386585012588 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 386585012589 putative ligand binding site [chemical binding]; other site 386585012590 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 386585012591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585012592 Walker A/P-loop; other site 386585012593 ATP binding site [chemical binding]; other site 386585012594 Q-loop/lid; other site 386585012595 ABC transporter signature motif; other site 386585012596 Walker B; other site 386585012597 D-loop; other site 386585012598 H-loop/switch region; other site 386585012599 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585012600 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585012601 TM-ABC transporter signature motif; other site 386585012602 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 386585012603 putative dimerization interface [polypeptide binding]; other site 386585012604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 386585012605 putative ligand binding site [chemical binding]; other site 386585012606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012607 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585012608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012609 hypothetical protein; Provisional; Region: PRK10356 386585012610 Lysozyme subfamily 2; Region: LYZ2; smart00047 386585012611 alpha-amylase; Reviewed; Region: malS; PRK09505 386585012612 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 386585012613 active site 386585012614 catalytic site [active] 386585012615 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 386585012616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585012617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585012618 homodimer interface [polypeptide binding]; other site 386585012619 catalytic residue [active] 386585012620 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 386585012621 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585012622 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 386585012623 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 386585012624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585012625 putative symporter YagG; Provisional; Region: PRK09669; cl15392 386585012626 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 386585012627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 386585012628 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 386585012629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 386585012630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585012631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585012632 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 386585012633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585012634 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585012635 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 386585012636 FlxA-like protein; Region: FlxA; pfam14282 386585012637 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 386585012638 NAD(P) binding site [chemical binding]; other site 386585012639 catalytic residues [active] 386585012640 Fic family protein [Function unknown]; Region: COG3177 386585012641 Fic/DOC family; Region: Fic; pfam02661 386585012642 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 386585012643 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 386585012644 dimer interface [polypeptide binding]; other site 386585012645 active site 386585012646 metal binding site [ion binding]; metal-binding site 386585012647 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 386585012648 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 386585012649 G1 box; other site 386585012650 putative GEF interaction site [polypeptide binding]; other site 386585012651 GTP/Mg2+ binding site [chemical binding]; other site 386585012652 Switch I region; other site 386585012653 G2 box; other site 386585012654 G3 box; other site 386585012655 Switch II region; other site 386585012656 G4 box; other site 386585012657 G5 box; other site 386585012658 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 386585012659 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 386585012660 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 386585012661 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 386585012662 selenocysteine synthase; Provisional; Region: PRK04311 386585012663 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 386585012664 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 386585012665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585012666 catalytic residue [active] 386585012667 putative glutathione S-transferase; Provisional; Region: PRK10357 386585012668 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 386585012669 putative C-terminal domain interface [polypeptide binding]; other site 386585012670 putative GSH binding site (G-site) [chemical binding]; other site 386585012671 putative dimer interface [polypeptide binding]; other site 386585012672 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 386585012673 dimer interface [polypeptide binding]; other site 386585012674 N-terminal domain interface [polypeptide binding]; other site 386585012675 putative substrate binding pocket (H-site) [chemical binding]; other site 386585012676 PAAR motif; Region: PAAR_motif; cl15808 386585012677 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585012678 RHS Repeat; Region: RHS_repeat; pfam05593 386585012679 RHS Repeat; Region: RHS_repeat; pfam05593 386585012680 RHS Repeat; Region: RHS_repeat; pfam05593 386585012681 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585012682 RHS Repeat; Region: RHS_repeat; pfam05593 386585012683 RHS Repeat; Region: RHS_repeat; pfam05593 386585012684 RHS protein; Region: RHS; pfam03527 386585012685 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585012686 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 386585012687 Immunity protein 34; Region: Imm34; pfam15596 386585012688 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 386585012689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585012690 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585012691 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 386585012692 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 386585012693 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 386585012694 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 386585012695 active site 386585012696 P-loop; other site 386585012697 phosphorylation site [posttranslational modification] 386585012698 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585012699 active site 386585012700 phosphorylation site [posttranslational modification] 386585012701 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 386585012702 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 386585012703 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 386585012704 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 386585012705 hypothetical protein; Provisional; Region: PRK11020 386585012706 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 386585012707 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 386585012708 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 386585012709 trimer interface [polypeptide binding]; other site 386585012710 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 386585012711 trimer interface [polypeptide binding]; other site 386585012712 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 386585012713 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 386585012714 trimer interface [polypeptide binding]; other site 386585012715 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 386585012716 trimer interface [polypeptide binding]; other site 386585012717 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 386585012718 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 386585012719 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 386585012720 L-lactate permease; Provisional; Region: PRK10420 386585012721 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 386585012722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585012723 DNA-binding site [nucleotide binding]; DNA binding site 386585012724 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585012725 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 386585012726 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 386585012727 active site 386585012728 substrate binding site [chemical binding]; other site 386585012729 FMN binding site [chemical binding]; other site 386585012730 putative catalytic residues [active] 386585012731 putative rRNA methylase; Provisional; Region: PRK10358 386585012732 serine acetyltransferase; Provisional; Region: cysE; PRK11132 386585012733 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 386585012734 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 386585012735 trimer interface [polypeptide binding]; other site 386585012736 active site 386585012737 substrate binding site [chemical binding]; other site 386585012738 CoA binding site [chemical binding]; other site 386585012739 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 386585012740 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 386585012741 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 386585012742 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 386585012743 SecA binding site; other site 386585012744 Preprotein binding site; other site 386585012745 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 386585012746 GSH binding site [chemical binding]; other site 386585012747 catalytic residues [active] 386585012748 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 386585012749 active site residue [active] 386585012750 phosphoglyceromutase; Provisional; Region: PRK05434 386585012751 AmiB activator; Provisional; Region: PRK11637 386585012752 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 386585012753 HemX; Region: HemX; cl19375 386585012754 Peptidase family M23; Region: Peptidase_M23; pfam01551 386585012755 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 386585012756 NodB motif; other site 386585012757 putative active site [active] 386585012758 putative catalytic site [active] 386585012759 Zn binding site [ion binding]; other site 386585012760 putative glycosyl transferase; Provisional; Region: PRK10073 386585012761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 386585012762 active site 386585012763 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 386585012764 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 386585012765 NAD(P) binding site [chemical binding]; other site 386585012766 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 386585012767 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 386585012768 substrate-cofactor binding pocket; other site 386585012769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585012770 catalytic residue [active] 386585012771 hypothetical protein; Provisional; Region: PRK11346 386585012772 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 386585012773 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 386585012774 NADP binding site [chemical binding]; other site 386585012775 homopentamer interface [polypeptide binding]; other site 386585012776 substrate binding site [chemical binding]; other site 386585012777 active site 386585012778 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 386585012779 putative active site [active] 386585012780 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 386585012781 putative active site [active] 386585012782 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 386585012783 O-antigen ligase RfaL; Provisional; Region: PRK15487 386585012784 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 386585012785 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 386585012786 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 386585012787 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 386585012788 Ligand binding site; other site 386585012789 metal-binding site 386585012790 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 386585012791 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 386585012792 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 386585012793 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 386585012794 Ligand binding site; other site 386585012795 metal-binding site 386585012796 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 386585012797 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 386585012798 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 386585012799 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 386585012800 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 386585012801 putative active site [active] 386585012802 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 386585012803 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 386585012804 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 386585012805 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 386585012806 active site 386585012807 (T/H)XGH motif; other site 386585012808 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 386585012809 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 386585012810 DNA binding site [nucleotide binding] 386585012811 catalytic residue [active] 386585012812 H2TH interface [polypeptide binding]; other site 386585012813 putative catalytic residues [active] 386585012814 turnover-facilitating residue; other site 386585012815 intercalation triad [nucleotide binding]; other site 386585012816 8OG recognition residue [nucleotide binding]; other site 386585012817 putative reading head residues; other site 386585012818 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 386585012819 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 386585012820 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 386585012821 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 386585012822 hypothetical protein; Reviewed; Region: PRK00024 386585012823 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 386585012824 MPN+ (JAMM) motif; other site 386585012825 Zinc-binding site [ion binding]; other site 386585012826 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 386585012827 Flavoprotein; Region: Flavoprotein; cl19190 386585012828 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 386585012829 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 386585012830 trimer interface [polypeptide binding]; other site 386585012831 active site 386585012832 division inhibitor protein; Provisional; Region: slmA; PRK09480 386585012833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585012834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 386585012835 active site 386585012836 ribonuclease PH; Reviewed; Region: rph; PRK00173 386585012837 Ribonuclease PH; Region: RNase_PH_bact; cd11362 386585012838 hexamer interface [polypeptide binding]; other site 386585012839 active site 386585012840 hypothetical protein; Provisional; Region: PRK11820 386585012841 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 386585012842 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 386585012843 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 386585012844 BRO family, N-terminal domain; Region: Bro-N; pfam02498 386585012845 Predicted membrane protein [Function unknown]; Region: COG2860 386585012846 UPF0126 domain; Region: UPF0126; pfam03458 386585012847 UPF0126 domain; Region: UPF0126; pfam03458 386585012848 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 386585012849 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 386585012850 nucleotide binding pocket [chemical binding]; other site 386585012851 K-X-D-G motif; other site 386585012852 catalytic site [active] 386585012853 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 386585012854 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 386585012855 Guanylate kinase; Region: Guanylate_kin; pfam00625 386585012856 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 386585012857 catalytic site [active] 386585012858 G-X2-G-X-G-K; other site 386585012859 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 386585012860 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 386585012861 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 386585012862 Zn2+ binding site [ion binding]; other site 386585012863 Mg2+ binding site [ion binding]; other site 386585012864 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 386585012865 synthetase active site [active] 386585012866 NTP binding site [chemical binding]; other site 386585012867 metal binding site [ion binding]; metal-binding site 386585012868 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 386585012869 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 386585012870 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 386585012871 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 386585012872 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 386585012873 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 386585012874 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 386585012875 generic binding surface II; other site 386585012876 ssDNA binding site; other site 386585012877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585012878 ATP binding site [chemical binding]; other site 386585012879 putative Mg++ binding site [ion binding]; other site 386585012880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585012881 nucleotide binding region [chemical binding]; other site 386585012882 ATP-binding site [chemical binding]; other site 386585012883 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 386585012884 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 386585012885 Sulfate transporter family; Region: Sulfate_transp; cl19250 386585012886 AsmA family; Region: AsmA; pfam05170 386585012887 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 386585012888 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 386585012889 putative alpha-glucosidase; Provisional; Region: PRK10658 386585012890 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 386585012891 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 386585012892 active site 386585012893 homotrimer interface [polypeptide binding]; other site 386585012894 catalytic site [active] 386585012895 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 386585012896 putative transporter; Provisional; Region: PRK11462 386585012897 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 386585012898 integrase; Provisional; Region: PRK09692 386585012899 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585012900 active site 386585012901 Int/Topo IB signature motif; other site 386585012902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585012903 Transposase; Region: HTH_Tnp_1; cl17663 386585012904 Integrase core domain; Region: rve; pfam00665 386585012905 DDE domain; Region: DDE_Tnp_IS240; pfam13610 386585012906 Integrase core domain; Region: rve_3; pfam13683 386585012907 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 386585012908 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 386585012909 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 386585012910 Methyltransferase domain; Region: Methyltransf_27; pfam13708 386585012911 Transposase; Region: HTH_Tnp_1; pfam01527 386585012912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585012913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585012914 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 386585012915 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 386585012916 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 386585012917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 386585012918 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 386585012919 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 386585012920 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 386585012921 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 386585012922 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 386585012923 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 386585012924 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 386585012925 Enterobacterial EspB protein; Region: EspB; pfam05802 386585012926 Uncharacterized conserved protein [Function unknown]; Region: COG5613 386585012927 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 386585012928 EspA-like secreted protein; Region: EspA; pfam03433 386585012929 type III secretion system protein SsaL; Provisional; Region: PRK15345 386585012930 HrpJ-like domain; Region: HrpJ; pfam07201 386585012931 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 386585012932 type III secretion system protein SsaD; Provisional; Region: PRK15367 386585012933 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 386585012934 LysM domain; Region: LysM; pfam01476 386585012935 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 386585012936 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 386585012937 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585012938 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 386585012939 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 386585012940 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 386585012941 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 386585012942 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 386585012943 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 386585012944 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 386585012945 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 386585012946 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 386585012947 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 386585012948 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 386585012949 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 386585012950 Walker A motif; other site 386585012951 ATP binding site [chemical binding]; other site 386585012952 Walker B motif; other site 386585012953 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 386585012954 SepZ; Region: SepZ; pfam06066 386585012955 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 386585012956 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 386585012957 outer membrane secretin SsaC; Provisional; Region: PRK15346 386585012958 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 386585012959 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 386585012960 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 386585012961 Tetratricopeptide repeat; Region: TPR_3; pfam07720 386585012962 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 386585012963 negative regulator GrlR; Provisional; Region: PRK14051 386585012964 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 386585012965 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585012966 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585012967 catalytic residue [active] 386585012968 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 386585012969 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 386585012970 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 386585012971 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 386585012972 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 386585012973 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 386585012974 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 386585012975 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 386585012976 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 386585012977 EspG protein; Region: EspG; pfam06872 386585012978 SdiA-regulated; Region: SdiA-regulated; cd09971 386585012979 putative active site [active] 386585012980 EamA-like transporter family; Region: EamA; pfam00892 386585012981 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 386585012982 EamA-like transporter family; Region: EamA; pfam00892 386585012983 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 386585012984 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 386585012985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585012986 putative substrate translocation pore; other site 386585012987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 386585012988 Predicted transcriptional regulator [Transcription]; Region: COG2944 386585012989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585012990 non-specific DNA binding site [nucleotide binding]; other site 386585012991 salt bridge; other site 386585012992 sequence-specific DNA binding site [nucleotide binding]; other site 386585012993 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 386585012994 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 386585012995 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 386585012996 Sulfate transporter family; Region: Sulfate_transp; cl19250 386585012997 cryptic adenine deaminase; Provisional; Region: PRK10027 386585012998 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 386585012999 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 386585013000 active site 386585013001 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 386585013002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013003 putative substrate translocation pore; other site 386585013004 regulatory protein UhpC; Provisional; Region: PRK11663 386585013005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013006 putative substrate translocation pore; other site 386585013007 sensory histidine kinase UhpB; Provisional; Region: PRK11644 386585013008 MASE1; Region: MASE1; pfam05231 386585013009 Histidine kinase; Region: HisKA_3; pfam07730 386585013010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585013011 ATP binding site [chemical binding]; other site 386585013012 Mg2+ binding site [ion binding]; other site 386585013013 G-X-G motif; other site 386585013014 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 386585013015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585013016 active site 386585013017 phosphorylation site [posttranslational modification] 386585013018 intermolecular recognition site; other site 386585013019 dimerization interface [polypeptide binding]; other site 386585013020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585013021 DNA binding residues [nucleotide binding] 386585013022 dimerization interface [polypeptide binding]; other site 386585013023 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 386585013024 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 386585013025 putative valine binding site [chemical binding]; other site 386585013026 dimer interface [polypeptide binding]; other site 386585013027 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 386585013028 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 386585013029 PYR/PP interface [polypeptide binding]; other site 386585013030 dimer interface [polypeptide binding]; other site 386585013031 TPP binding site [chemical binding]; other site 386585013032 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 386585013033 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 386585013034 TPP-binding site [chemical binding]; other site 386585013035 dimer interface [polypeptide binding]; other site 386585013036 ilvB operon leader peptide; Provisional; Region: PRK10214 386585013037 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 386585013038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013039 putative substrate translocation pore; other site 386585013040 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 386585013041 Domain of unknown function (DUF202); Region: DUF202; pfam02656 386585013042 Predicted membrane protein [Function unknown]; Region: COG2149 386585013043 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 386585013044 Sulfatase; Region: Sulfatase; pfam00884 386585013045 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 386585013046 Na binding site [ion binding]; other site 386585013047 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 386585013048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585013050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013051 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 386585013052 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 386585013053 NAD binding site [chemical binding]; other site 386585013054 sugar binding site [chemical binding]; other site 386585013055 divalent metal binding site [ion binding]; other site 386585013056 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585013057 dimer interface [polypeptide binding]; other site 386585013058 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 386585013059 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 386585013060 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585013061 active site turn [active] 386585013062 phosphorylation site [posttranslational modification] 386585013063 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 386585013064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585013065 DNA-binding site [nucleotide binding]; DNA binding site 386585013066 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 386585013067 putative transporter; Validated; Region: PRK03818 386585013068 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 386585013069 TrkA-C domain; Region: TrkA_C; pfam02080 386585013070 TrkA-C domain; Region: TrkA_C; pfam02080 386585013071 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 386585013072 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 386585013073 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 386585013074 putative dimer interface [polypeptide binding]; other site 386585013075 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 386585013076 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 386585013077 putative dimer interface [polypeptide binding]; other site 386585013078 hypothetical protein; Provisional; Region: PRK11616 386585013079 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 386585013080 putative oxidoreductase; Provisional; Region: PRK11445 386585013081 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 386585013082 hypothetical protein; Provisional; Region: PRK10215 386585013083 sugar phosphate phosphatase; Provisional; Region: PRK10513 386585013084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585013085 active site 386585013086 motif I; other site 386585013087 motif II; other site 386585013088 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585013089 hypothetical protein; Provisional; Region: PRK11426 386585013090 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 386585013091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585013092 ATP binding site [chemical binding]; other site 386585013093 Mg2+ binding site [ion binding]; other site 386585013094 G-X-G motif; other site 386585013095 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 386585013096 anchoring element; other site 386585013097 dimer interface [polypeptide binding]; other site 386585013098 ATP binding site [chemical binding]; other site 386585013099 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 386585013100 active site 386585013101 putative metal-binding site [ion binding]; other site 386585013102 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 386585013103 recF protein; Region: recf; TIGR00611 386585013104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585013105 Walker A/P-loop; other site 386585013106 ATP binding site [chemical binding]; other site 386585013107 Q-loop/lid; other site 386585013108 ABC transporter signature motif; other site 386585013109 Walker B; other site 386585013110 D-loop; other site 386585013111 H-loop/switch region; other site 386585013112 DNA polymerase III subunit beta; Validated; Region: PRK05643 386585013113 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 386585013114 putative DNA binding surface [nucleotide binding]; other site 386585013115 dimer interface [polypeptide binding]; other site 386585013116 beta-clamp/clamp loader binding surface; other site 386585013117 beta-clamp/translesion DNA polymerase binding surface; other site 386585013118 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 386585013119 DnaA N-terminal domain; Region: DnaA_N; pfam11638 386585013120 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 386585013121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585013122 Walker A motif; other site 386585013123 ATP binding site [chemical binding]; other site 386585013124 Walker B motif; other site 386585013125 arginine finger; other site 386585013126 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 386585013127 DnaA box-binding interface [nucleotide binding]; other site 386585013128 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 386585013129 ribonuclease P; Reviewed; Region: rnpA; PRK01732 386585013130 membrane protein insertase; Provisional; Region: PRK01318 386585013131 YidC periplasmic domain; Region: YidC_periplas; pfam14849 386585013132 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 386585013133 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 386585013134 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 386585013135 trmE is a tRNA modification GTPase; Region: trmE; cd04164 386585013136 G1 box; other site 386585013137 GTP/Mg2+ binding site [chemical binding]; other site 386585013138 Switch I region; other site 386585013139 G2 box; other site 386585013140 Switch II region; other site 386585013141 G3 box; other site 386585013142 G4 box; other site 386585013143 G5 box; other site 386585013144 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 386585013145 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 386585013146 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 386585013147 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 386585013148 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 386585013149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 386585013150 catalytic residue [active] 386585013151 tryptophan permease TnaB; Provisional; Region: PRK09664 386585013152 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 386585013153 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 386585013154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013155 putative substrate translocation pore; other site 386585013156 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 386585013157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585013158 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 386585013159 substrate binding pocket [chemical binding]; other site 386585013160 dimerization interface [polypeptide binding]; other site 386585013161 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 386585013162 Predicted flavoprotein [General function prediction only]; Region: COG0431 386585013163 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 386585013164 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 386585013165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585013166 active site 386585013167 motif I; other site 386585013168 motif II; other site 386585013169 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 386585013170 Salmonella outer protein D; Region: SopD; cl14701 386585013171 transcriptional regulator PhoU; Provisional; Region: PRK11115 386585013172 PhoU domain; Region: PhoU; pfam01895 386585013173 PhoU domain; Region: PhoU; pfam01895 386585013174 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 386585013175 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 386585013176 Walker A/P-loop; other site 386585013177 ATP binding site [chemical binding]; other site 386585013178 Q-loop/lid; other site 386585013179 ABC transporter signature motif; other site 386585013180 Walker B; other site 386585013181 D-loop; other site 386585013182 H-loop/switch region; other site 386585013183 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 386585013184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585013185 dimer interface [polypeptide binding]; other site 386585013186 conserved gate region; other site 386585013187 putative PBP binding loops; other site 386585013188 ABC-ATPase subunit interface; other site 386585013189 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 386585013190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585013191 dimer interface [polypeptide binding]; other site 386585013192 conserved gate region; other site 386585013193 putative PBP binding loops; other site 386585013194 ABC-ATPase subunit interface; other site 386585013195 phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918 386585013196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585013197 Fimbrial protein; Region: Fimbrial; cl01416 386585013198 Fimbrial protein; Region: Fimbrial; cl01416 386585013199 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 386585013200 PapC N-terminal domain; Region: PapC_N; pfam13954 386585013201 Outer membrane usher protein; Region: Usher; pfam00577 386585013202 PapC C-terminal domain; Region: PapC_C; pfam13953 386585013203 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585013204 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585013205 fimbrial protein; Provisional; Region: lpfA; PRK15289 386585013206 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 386585013207 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 386585013208 glutaminase active site [active] 386585013209 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 386585013210 dimer interface [polypeptide binding]; other site 386585013211 active site 386585013212 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 386585013213 dimer interface [polypeptide binding]; other site 386585013214 active site 386585013215 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 386585013216 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 386585013217 Substrate binding site; other site 386585013218 Mg++ binding site; other site 386585013219 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 386585013220 active site 386585013221 substrate binding site [chemical binding]; other site 386585013222 CoA binding site [chemical binding]; other site 386585013223 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 386585013224 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 386585013225 gamma subunit interface [polypeptide binding]; other site 386585013226 epsilon subunit interface [polypeptide binding]; other site 386585013227 LBP interface [polypeptide binding]; other site 386585013228 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 386585013229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 386585013230 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 386585013231 alpha subunit interaction interface [polypeptide binding]; other site 386585013232 Walker A motif; other site 386585013233 ATP binding site [chemical binding]; other site 386585013234 Walker B motif; other site 386585013235 inhibitor binding site; inhibition site 386585013236 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 386585013237 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 386585013238 core domain interface [polypeptide binding]; other site 386585013239 delta subunit interface [polypeptide binding]; other site 386585013240 epsilon subunit interface [polypeptide binding]; other site 386585013241 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 386585013242 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 386585013243 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 386585013244 beta subunit interaction interface [polypeptide binding]; other site 386585013245 Walker A motif; other site 386585013246 ATP binding site [chemical binding]; other site 386585013247 Walker B motif; other site 386585013248 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 386585013249 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 386585013250 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 386585013251 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 386585013252 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 386585013253 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 386585013254 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 386585013255 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 386585013256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585013257 S-adenosylmethionine binding site [chemical binding]; other site 386585013258 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 386585013259 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 386585013260 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 386585013261 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 386585013262 FMN-binding protein MioC; Provisional; Region: PRK09004 386585013263 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 386585013264 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585013265 putative DNA binding site [nucleotide binding]; other site 386585013266 putative Zn2+ binding site [ion binding]; other site 386585013267 AsnC family; Region: AsnC_trans_reg; pfam01037 386585013268 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 386585013269 dimer interface [polypeptide binding]; other site 386585013270 active site 386585013271 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 386585013272 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 386585013273 metal ion-dependent adhesion site (MIDAS); other site 386585013274 regulatory ATPase RavA; Provisional; Region: PRK13531 386585013275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585013276 Walker A motif; other site 386585013277 ATP binding site [chemical binding]; other site 386585013278 Walker B motif; other site 386585013279 arginine finger; other site 386585013280 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 386585013281 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 386585013282 D-ribose pyranase; Provisional; Region: PRK11797 386585013283 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 386585013284 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585013285 Walker A/P-loop; other site 386585013286 ATP binding site [chemical binding]; other site 386585013287 Q-loop/lid; other site 386585013288 ABC transporter signature motif; other site 386585013289 Walker B; other site 386585013290 D-loop; other site 386585013291 H-loop/switch region; other site 386585013292 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585013293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585013294 TM-ABC transporter signature motif; other site 386585013295 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 386585013296 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 386585013297 ligand binding site [chemical binding]; other site 386585013298 dimerization interface [polypeptide binding]; other site 386585013299 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 386585013300 substrate binding site [chemical binding]; other site 386585013301 dimer interface [polypeptide binding]; other site 386585013302 ATP binding site [chemical binding]; other site 386585013303 transcriptional repressor RbsR; Provisional; Region: PRK10423 386585013304 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585013305 DNA binding site [nucleotide binding] 386585013306 domain linker motif; other site 386585013307 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 386585013308 dimerization interface [polypeptide binding]; other site 386585013309 ligand binding site [chemical binding]; other site 386585013310 putative transporter; Provisional; Region: PRK10504 386585013311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013312 putative substrate translocation pore; other site 386585013313 Transcriptional regulators [Transcription]; Region: FadR; COG2186 386585013314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585013315 DNA-binding site [nucleotide binding]; DNA binding site 386585013316 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585013317 transcriptional regulator HdfR; Provisional; Region: PRK03601 386585013318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585013319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 386585013320 dimerization interface [polypeptide binding]; other site 386585013321 hypothetical protein; Provisional; Region: PRK11027 386585013322 putative ATP-dependent protease; Provisional; Region: PRK09862 386585013323 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 386585013324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585013325 Walker A motif; other site 386585013326 ATP binding site [chemical binding]; other site 386585013327 Walker B motif; other site 386585013328 arginine finger; other site 386585013329 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 386585013330 ilvG operon leader peptide; Provisional; Region: PRK10424 386585013331 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 386585013332 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 386585013333 PYR/PP interface [polypeptide binding]; other site 386585013334 dimer interface [polypeptide binding]; other site 386585013335 TPP binding site [chemical binding]; other site 386585013336 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 386585013337 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 386585013338 TPP-binding site [chemical binding]; other site 386585013339 dimer interface [polypeptide binding]; other site 386585013340 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 386585013341 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 386585013342 homodimer interface [polypeptide binding]; other site 386585013343 substrate-cofactor binding pocket; other site 386585013344 catalytic residue [active] 386585013345 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 386585013346 threonine dehydratase; Reviewed; Region: PRK09224 386585013347 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 386585013348 tetramer interface [polypeptide binding]; other site 386585013349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585013350 catalytic residue [active] 386585013351 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 386585013352 putative Ile/Val binding site [chemical binding]; other site 386585013353 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 386585013354 putative Ile/Val binding site [chemical binding]; other site 386585013355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585013356 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 386585013357 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 386585013358 putative dimerization interface [polypeptide binding]; other site 386585013359 ketol-acid reductoisomerase; Validated; Region: PRK05225 386585013360 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 386585013361 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 386585013362 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 386585013363 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 386585013364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 386585013365 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 386585013366 Part of AAA domain; Region: AAA_19; pfam13245 386585013367 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 386585013368 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 386585013369 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 386585013370 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 386585013371 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 386585013372 ATP binding site [chemical binding]; other site 386585013373 Mg++ binding site [ion binding]; other site 386585013374 motif III; other site 386585013375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585013376 nucleotide binding region [chemical binding]; other site 386585013377 ATP-binding site [chemical binding]; other site 386585013378 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 386585013379 catalytic residues [active] 386585013380 putative rho operon leader peptide; Provisional; Region: PRK09979 386585013381 transcription termination factor Rho; Provisional; Region: rho; PRK09376 386585013382 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 386585013383 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 386585013384 RNA binding site [nucleotide binding]; other site 386585013385 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 386585013386 multimer interface [polypeptide binding]; other site 386585013387 Walker A motif; other site 386585013388 ATP binding site [chemical binding]; other site 386585013389 Walker B motif; other site 386585013390 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 386585013391 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 386585013392 Mg++ binding site [ion binding]; other site 386585013393 putative catalytic motif [active] 386585013394 substrate binding site [chemical binding]; other site 386585013395 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 386585013396 Chain length determinant protein; Region: Wzz; pfam02706 386585013397 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 386585013398 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 386585013399 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 386585013400 active site 386585013401 homodimer interface [polypeptide binding]; other site 386585013402 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 386585013403 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 386585013404 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 386585013405 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 386585013406 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 386585013407 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 386585013408 NAD binding site [chemical binding]; other site 386585013409 substrate binding site [chemical binding]; other site 386585013410 homodimer interface [polypeptide binding]; other site 386585013411 active site 386585013412 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 386585013413 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 386585013414 substrate binding site; other site 386585013415 tetramer interface; other site 386585013416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 386585013417 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 386585013418 inhibitor-cofactor binding pocket; inhibition site 386585013419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585013420 catalytic residue [active] 386585013421 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 386585013422 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 386585013423 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 386585013424 putative common antigen polymerase; Provisional; Region: PRK02975 386585013425 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 386585013426 putative transport protein YifK; Provisional; Region: PRK10746 386585013427 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 386585013428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585013429 FeS/SAM binding site; other site 386585013430 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 386585013431 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 386585013432 Sulfatase; Region: Sulfatase; pfam00884 386585013433 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 386585013434 HemY protein N-terminus; Region: HemY_N; pfam07219 386585013435 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 386585013436 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 386585013437 active site 386585013438 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 386585013439 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 386585013440 domain interfaces; other site 386585013441 active site 386585013442 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 386585013443 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 386585013444 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 386585013445 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 386585013446 putative iron binding site [ion binding]; other site 386585013447 hypothetical protein; Provisional; Region: PRK09807 386585013448 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 386585013449 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 386585013450 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 386585013451 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 386585013452 hypothetical protein; Provisional; Region: PRK10963 386585013453 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 386585013454 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 386585013455 active site 386585013456 Int/Topo IB signature motif; other site 386585013457 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 386585013458 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 386585013459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585013460 motif II; other site 386585013461 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 386585013462 Part of AAA domain; Region: AAA_19; pfam13245 386585013463 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 386585013464 Uncharacterized conserved protein [Function unknown]; Region: COG1912 386585013465 Predicted periplasmic protein [Function unknown]; Region: COG3698 386585013466 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 386585013467 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 386585013468 Cl binding site [ion binding]; other site 386585013469 oligomer interface [polypeptide binding]; other site 386585013470 conserved hypothetical protein; Region: TIGR03034 386585013471 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 386585013472 Multidrug resistance efflux transporter; Region: EmrE; cl19304 386585013473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 386585013474 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 386585013475 CoenzymeA binding site [chemical binding]; other site 386585013476 subunit interaction site [polypeptide binding]; other site 386585013477 PHB binding site; other site 386585013478 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 386585013479 dimerization interface [polypeptide binding]; other site 386585013480 substrate binding site [chemical binding]; other site 386585013481 active site 386585013482 calcium binding site [ion binding]; other site 386585013483 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 386585013484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585013485 ATP binding site [chemical binding]; other site 386585013486 putative Mg++ binding site [ion binding]; other site 386585013487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585013488 nucleotide binding region [chemical binding]; other site 386585013489 ATP-binding site [chemical binding]; other site 386585013490 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 386585013491 Helicase and RNase D C-terminal; Region: HRDC; smart00341 386585013492 threonine efflux system; Provisional; Region: PRK10229 386585013493 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 386585013494 lysophospholipase L2; Provisional; Region: PRK10749 386585013495 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 386585013496 putative hydrolase; Provisional; Region: PRK10976 386585013497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585013498 active site 386585013499 motif I; other site 386585013500 motif II; other site 386585013501 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 386585013502 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 386585013503 EamA-like transporter family; Region: EamA; pfam00892 386585013504 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 386585013505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585013506 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 386585013507 putative dimerization interface [polypeptide binding]; other site 386585013508 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 386585013509 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 386585013510 THF binding site; other site 386585013511 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 386585013512 substrate binding site [chemical binding]; other site 386585013513 THF binding site; other site 386585013514 zinc-binding site [ion binding]; other site 386585013515 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 386585013516 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 386585013517 uridine phosphorylase; Provisional; Region: PRK11178 386585013518 DNA recombination protein RmuC; Provisional; Region: PRK10361 386585013519 RmuC family; Region: RmuC; pfam02646 386585013520 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 386585013521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585013522 S-adenosylmethionine binding site [chemical binding]; other site 386585013523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 386585013524 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 386585013525 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 386585013526 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 386585013527 sec-independent translocase; Provisional; Region: PRK01770 386585013528 sec-independent translocase; Provisional; Region: tatB; PRK00404 386585013529 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 386585013530 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 386585013531 active site 386585013532 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 386585013533 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 386585013534 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 386585013535 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 386585013536 FMN reductase; Validated; Region: fre; PRK08051 386585013537 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 386585013538 FAD binding pocket [chemical binding]; other site 386585013539 FAD binding motif [chemical binding]; other site 386585013540 phosphate binding motif [ion binding]; other site 386585013541 beta-alpha-beta structure motif; other site 386585013542 NAD binding pocket [chemical binding]; other site 386585013543 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 386585013544 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 386585013545 dimer interface [polypeptide binding]; other site 386585013546 active site 386585013547 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 386585013548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 386585013549 substrate binding site [chemical binding]; other site 386585013550 oxyanion hole (OAH) forming residues; other site 386585013551 trimer interface [polypeptide binding]; other site 386585013552 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 386585013553 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 386585013554 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 386585013555 proline dipeptidase; Provisional; Region: PRK13607 386585013556 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 386585013557 active site 386585013558 hypothetical protein; Provisional; Region: PRK11568 386585013559 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 386585013560 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 386585013561 potassium transporter; Provisional; Region: PRK10750 386585013562 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 386585013563 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 386585013564 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 386585013565 Walker A motif; other site 386585013566 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 386585013567 GTP binding site; other site 386585013568 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 386585013569 serine/threonine protein kinase; Provisional; Region: PRK11768 386585013570 Phosphotransferase enzyme family; Region: APH; pfam01636 386585013571 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 386585013572 catalytic residues [active] 386585013573 hinge region; other site 386585013574 alpha helical domain; other site 386585013575 hypothetical protein; Provisional; Region: PRK11367 386585013576 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 386585013577 putative acyl-acceptor binding pocket; other site 386585013578 DNA polymerase I; Provisional; Region: PRK05755 386585013579 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 386585013580 active site 386585013581 metal binding site 1 [ion binding]; metal-binding site 386585013582 putative 5' ssDNA interaction site; other site 386585013583 metal binding site 3; metal-binding site 386585013584 metal binding site 2 [ion binding]; metal-binding site 386585013585 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 386585013586 putative DNA binding site [nucleotide binding]; other site 386585013587 putative metal binding site [ion binding]; other site 386585013588 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 386585013589 active site 386585013590 catalytic site [active] 386585013591 substrate binding site [chemical binding]; other site 386585013592 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 386585013593 active site 386585013594 DNA binding site [nucleotide binding] 386585013595 catalytic site [active] 386585013596 Predicted GTPase [General function prediction only]; Region: COG0218 386585013597 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 386585013598 G1 box; other site 386585013599 GTP/Mg2+ binding site [chemical binding]; other site 386585013600 Switch I region; other site 386585013601 G2 box; other site 386585013602 G3 box; other site 386585013603 Switch II region; other site 386585013604 G4 box; other site 386585013605 G5 box; other site 386585013606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 386585013607 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 386585013608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585013609 FeS/SAM binding site; other site 386585013610 HemN C-terminal domain; Region: HemN_C; pfam06969 386585013611 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 386585013612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585013613 active site 386585013614 phosphorylation site [posttranslational modification] 386585013615 intermolecular recognition site; other site 386585013616 dimerization interface [polypeptide binding]; other site 386585013617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585013618 Walker A motif; other site 386585013619 ATP binding site [chemical binding]; other site 386585013620 Walker B motif; other site 386585013621 arginine finger; other site 386585013622 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 386585013623 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 386585013624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585013625 putative active site [active] 386585013626 heme pocket [chemical binding]; other site 386585013627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585013628 dimer interface [polypeptide binding]; other site 386585013629 phosphorylation site [posttranslational modification] 386585013630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585013631 ATP binding site [chemical binding]; other site 386585013632 Mg2+ binding site [ion binding]; other site 386585013633 G-X-G motif; other site 386585013634 glutamine synthetase; Provisional; Region: glnA; PRK09469 386585013635 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 386585013636 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 386585013637 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 386585013638 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 386585013639 G1 box; other site 386585013640 putative GEF interaction site [polypeptide binding]; other site 386585013641 GTP/Mg2+ binding site [chemical binding]; other site 386585013642 Switch I region; other site 386585013643 G2 box; other site 386585013644 G3 box; other site 386585013645 Switch II region; other site 386585013646 G4 box; other site 386585013647 G5 box; other site 386585013648 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 386585013649 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 386585013650 transcriptional regulator protein; Region: phnR; TIGR03337 386585013651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585013652 DNA-binding site [nucleotide binding]; DNA binding site 386585013653 UTRA domain; Region: UTRA; pfam07702 386585013654 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 386585013655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013656 putative substrate translocation pore; other site 386585013657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585013658 outer membrane porin L; Provisional; Region: ompL; PRK09980 386585013659 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 386585013660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013661 putative substrate translocation pore; other site 386585013662 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 386585013663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013664 putative substrate translocation pore; other site 386585013665 alpha-glucosidase; Provisional; Region: PRK10426 386585013666 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 386585013667 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 386585013668 putative active site [active] 386585013669 putative catalytic site [active] 386585013670 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 386585013671 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 386585013672 active site 386585013673 catalytic residues [active] 386585013674 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 386585013675 dimerization interface [polypeptide binding]; other site 386585013676 putative active cleft [active] 386585013677 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 386585013678 catalytic residue [active] 386585013679 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 386585013680 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 386585013681 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 386585013682 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 386585013683 substrate binding site [chemical binding]; other site 386585013684 ATP binding site [chemical binding]; other site 386585013685 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 386585013686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585013687 putative DNA binding site [nucleotide binding]; other site 386585013688 putative Zn2+ binding site [ion binding]; other site 386585013689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585013690 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 386585013691 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 386585013692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585013693 motif II; other site 386585013694 hypothetical protein; Reviewed; Region: PRK01637 386585013695 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 386585013696 putative active site [active] 386585013697 dimerization interface [polypeptide binding]; other site 386585013698 putative tRNAtyr binding site [nucleotide binding]; other site 386585013699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585013700 Coenzyme A binding pocket [chemical binding]; other site 386585013701 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 386585013702 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 386585013703 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 386585013704 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 386585013705 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 386585013706 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585013707 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 386585013708 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 386585013709 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 386585013710 [4Fe-4S] binding site [ion binding]; other site 386585013711 molybdopterin cofactor binding site; other site 386585013712 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 386585013713 molybdopterin cofactor binding site; other site 386585013714 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 386585013715 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 386585013716 putative frv operon regulatory protein; Provisional; Region: PRK09863 386585013717 HTH domain; Region: HTH_11; pfam08279 386585013718 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585013719 active site 386585013720 phosphorylation site [posttranslational modification] 386585013721 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 386585013722 oligomer interface [polypeptide binding]; other site 386585013723 active site 386585013724 metal binding site [ion binding]; metal-binding site 386585013725 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 386585013726 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 386585013727 active site 386585013728 P-loop; other site 386585013729 phosphorylation site [posttranslational modification] 386585013730 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 386585013731 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585013732 active site 386585013733 phosphorylation site [posttranslational modification] 386585013734 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 386585013735 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 386585013736 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 386585013737 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 386585013738 intersubunit interface [polypeptide binding]; other site 386585013739 active site 386585013740 Zn2+ binding site [ion binding]; other site 386585013741 L-rhamnose isomerase; Provisional; Region: PRK01076 386585013742 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 386585013743 N- and C-terminal domain interface [polypeptide binding]; other site 386585013744 active site 386585013745 putative catalytic site [active] 386585013746 metal binding site [ion binding]; metal-binding site 386585013747 ATP binding site [chemical binding]; other site 386585013748 rhamnulokinase; Provisional; Region: rhaB; PRK10640 386585013749 carbohydrate binding site [chemical binding]; other site 386585013750 transcriptional activator RhaS; Provisional; Region: PRK13503 386585013751 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 386585013752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013754 transcriptional activator RhaR; Provisional; Region: PRK13500 386585013755 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 386585013756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013758 similar to RHAT_ECOLI gi|1790341 386585013759 superoxide dismutase; Provisional; Region: PRK10925 386585013760 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 386585013761 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 386585013762 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 386585013763 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 386585013764 MOSC domain; Region: MOSC; pfam03473 386585013765 3-alpha domain; Region: 3-alpha; pfam03475 386585013766 two-component sensor protein; Provisional; Region: cpxA; PRK09470 386585013767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585013768 dimerization interface [polypeptide binding]; other site 386585013769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585013770 dimer interface [polypeptide binding]; other site 386585013771 phosphorylation site [posttranslational modification] 386585013772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585013773 ATP binding site [chemical binding]; other site 386585013774 Mg2+ binding site [ion binding]; other site 386585013775 G-X-G motif; other site 386585013776 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 386585013777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585013778 active site 386585013779 intermolecular recognition site; other site 386585013780 dimerization interface [polypeptide binding]; other site 386585013781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585013782 DNA binding site [nucleotide binding] 386585013783 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 386585013784 dimer interface [polypeptide binding]; other site 386585013785 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 386585013786 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 386585013787 active site 386585013788 ADP/pyrophosphate binding site [chemical binding]; other site 386585013789 dimerization interface [polypeptide binding]; other site 386585013790 allosteric effector site; other site 386585013791 fructose-1,6-bisphosphate binding site; other site 386585013792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 386585013793 substrate binding pocket [chemical binding]; other site 386585013794 membrane-bound complex binding site; other site 386585013795 hinge residues; other site 386585013796 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 386585013797 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 386585013798 substrate binding site [chemical binding]; other site 386585013799 dimer interface [polypeptide binding]; other site 386585013800 catalytic triad [active] 386585013801 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 386585013802 Predicted membrane protein [Function unknown]; Region: COG3152 386585013803 hypothetical protein; Provisional; Region: PRK09981 386585013804 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 386585013805 Ligand Binding Site [chemical binding]; other site 386585013806 ferredoxin-NADP reductase; Provisional; Region: PRK10926 386585013807 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 386585013808 FAD binding pocket [chemical binding]; other site 386585013809 FAD binding motif [chemical binding]; other site 386585013810 phosphate binding motif [ion binding]; other site 386585013811 beta-alpha-beta structure motif; other site 386585013812 NAD binding pocket [chemical binding]; other site 386585013813 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 386585013814 putative active site [active] 386585013815 glycerol kinase; Provisional; Region: glpK; PRK00047 386585013816 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 386585013817 N- and C-terminal domain interface [polypeptide binding]; other site 386585013818 active site 386585013819 MgATP binding site [chemical binding]; other site 386585013820 catalytic site [active] 386585013821 metal binding site [ion binding]; metal-binding site 386585013822 glycerol binding site [chemical binding]; other site 386585013823 homotetramer interface [polypeptide binding]; other site 386585013824 homodimer interface [polypeptide binding]; other site 386585013825 FBP binding site [chemical binding]; other site 386585013826 protein IIAGlc interface [polypeptide binding]; other site 386585013827 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 386585013828 amphipathic channel; other site 386585013829 Asn-Pro-Ala signature motifs; other site 386585013830 septal ring assembly protein ZapB; Provisional; Region: PRK15422 386585013831 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 386585013832 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 386585013833 putative active site [active] 386585013834 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 386585013835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585013836 Walker A motif; other site 386585013837 ATP binding site [chemical binding]; other site 386585013838 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 386585013839 Walker B motif; other site 386585013840 arginine finger; other site 386585013841 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 386585013842 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 386585013843 active site 386585013844 HslU subunit interaction site [polypeptide binding]; other site 386585013845 essential cell division protein FtsN; Provisional; Region: PRK10927 386585013846 Sporulation related domain; Region: SPOR; pfam05036 386585013847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585013848 DNA binding site [nucleotide binding] 386585013849 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 386585013850 domain linker motif; other site 386585013851 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 386585013852 dimerization interface [polypeptide binding]; other site 386585013853 ligand binding site [chemical binding]; other site 386585013854 primosome assembly protein PriA; Validated; Region: PRK05580 386585013855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585013856 ATP binding site [chemical binding]; other site 386585013857 putative Mg++ binding site [ion binding]; other site 386585013858 helicase superfamily c-terminal domain; Region: HELICc; smart00490 386585013859 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 386585013860 PAAR motif; Region: PAAR_motif; cl15808 386585013861 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585013862 RHS Repeat; Region: RHS_repeat; pfam05593 386585013863 RHS Repeat; Region: RHS_repeat; pfam05593 386585013864 RHS Repeat; Region: RHS_repeat; pfam05593 386585013865 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 386585013866 RHS Repeat; Region: RHS_repeat; pfam05593 386585013867 RHS Repeat; Region: RHS_repeat; pfam05593 386585013868 RHS protein; Region: RHS; pfam03527 386585013869 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 386585013870 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 386585013871 hypothetical protein; Provisional; Region: PRK10030 386585013872 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 386585013873 dimerization interface [polypeptide binding]; other site 386585013874 DNA binding site [nucleotide binding] 386585013875 corepressor binding sites; other site 386585013876 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 386585013877 homodimer interface [polypeptide binding]; other site 386585013878 substrate-cofactor binding pocket; other site 386585013879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585013880 catalytic residue [active] 386585013881 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 386585013882 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 386585013883 putative catalytic residues [active] 386585013884 putative nucleotide binding site [chemical binding]; other site 386585013885 putative aspartate binding site [chemical binding]; other site 386585013886 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 386585013887 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 386585013888 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 386585013889 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 386585013890 FAD binding site [chemical binding]; other site 386585013891 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 386585013892 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 386585013893 heme binding site [chemical binding]; other site 386585013894 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 386585013895 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 386585013896 EamA-like transporter family; Region: EamA; pfam00892 386585013897 EamA-like transporter family; Region: EamA; pfam00892 386585013898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 386585013899 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 386585013900 dimer interface [polypeptide binding]; other site 386585013901 active site 386585013902 metal binding site [ion binding]; metal-binding site 386585013903 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 386585013904 active site 386585013905 intersubunit interactions; other site 386585013906 catalytic residue [active] 386585013907 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 386585013908 dimerization domain swap beta strand [polypeptide binding]; other site 386585013909 regulatory protein interface [polypeptide binding]; other site 386585013910 active site 386585013911 regulatory phosphorylation site [posttranslational modification]; other site 386585013912 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 386585013913 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 386585013914 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 386585013915 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 386585013916 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585013917 active site 386585013918 phosphorylation site [posttranslational modification] 386585013919 similar to PTS system, fructose-like enzyme IIC component FRWC_ECOLI gi|1790386; disrupted by frameshift 386585013920 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 386585013921 active site 386585013922 P-loop; other site 386585013923 phosphorylation site [posttranslational modification] 386585013924 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 386585013925 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 386585013926 dimer interface [polypeptide binding]; other site 386585013927 active site 386585013928 glycine loop; other site 386585013929 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 386585013930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585013931 FeS/SAM binding site; other site 386585013932 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 386585013933 active site 386585013934 P-loop; other site 386585013935 phosphorylation site [posttranslational modification] 386585013936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585013938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585013939 hypothetical protein; Provisional; Region: PRK10649 386585013940 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 386585013941 Sulfatase; Region: Sulfatase; pfam00884 386585013942 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 386585013943 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 386585013944 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 386585013945 metal binding site [ion binding]; metal-binding site 386585013946 putative dimer interface [polypeptide binding]; other site 386585013947 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 386585013948 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 386585013949 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 386585013950 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 386585013951 nucleotide binding site [chemical binding]; other site 386585013952 N-acetyl-L-glutamate binding site [chemical binding]; other site 386585013953 argininosuccinate lyase; Provisional; Region: PRK04833 386585013954 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 386585013955 active sites [active] 386585013956 tetramer interface [polypeptide binding]; other site 386585013957 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 386585013958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 386585013959 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 386585013960 dimerization interface [polypeptide binding]; other site 386585013961 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 386585013962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 386585013963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 386585013964 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 386585013965 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 386585013966 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 386585013967 metal binding site [ion binding]; metal-binding site 386585013968 putative dimer interface [polypeptide binding]; other site 386585013969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585013970 metabolite-proton symporter; Region: 2A0106; TIGR00883 386585013971 putative substrate translocation pore; other site 386585013972 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 386585013973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585013974 hypothetical protein; Provisional; Region: PRK11056 386585013975 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 386585013976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585013977 S-adenosylmethionine binding site [chemical binding]; other site 386585013978 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 386585013979 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 386585013980 N-terminal plug; other site 386585013981 ligand-binding site [chemical binding]; other site 386585013982 glutamate racemase; Provisional; Region: PRK00865 386585013983 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 386585013984 FAD binding domain; Region: FAD_binding_4; pfam01565 386585013985 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 386585013986 Biotin operon repressor [Transcription]; Region: BirA; COG1654 386585013987 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 386585013988 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 386585013989 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 386585013990 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 386585013991 ATP-binding site [chemical binding]; other site 386585013992 CoA-binding site [chemical binding]; other site 386585013993 Mg2+-binding site [ion binding]; other site 386585013994 elongation factor Tu; Reviewed; Region: PRK00049 386585013995 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 386585013996 G1 box; other site 386585013997 GEF interaction site [polypeptide binding]; other site 386585013998 GTP/Mg2+ binding site [chemical binding]; other site 386585013999 Switch I region; other site 386585014000 G2 box; other site 386585014001 G3 box; other site 386585014002 Switch II region; other site 386585014003 G4 box; other site 386585014004 G5 box; other site 386585014005 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 386585014006 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 386585014007 Antibiotic Binding Site [chemical binding]; other site 386585014008 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 386585014009 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 386585014010 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 386585014011 putative homodimer interface [polypeptide binding]; other site 386585014012 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 386585014013 heterodimer interface [polypeptide binding]; other site 386585014014 homodimer interface [polypeptide binding]; other site 386585014015 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 386585014016 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 386585014017 23S rRNA interface [nucleotide binding]; other site 386585014018 L7/L12 interface [polypeptide binding]; other site 386585014019 putative thiostrepton binding site; other site 386585014020 L25 interface [polypeptide binding]; other site 386585014021 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 386585014022 mRNA/rRNA interface [nucleotide binding]; other site 386585014023 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 386585014024 23S rRNA interface [nucleotide binding]; other site 386585014025 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 386585014026 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 386585014027 core dimer interface [polypeptide binding]; other site 386585014028 peripheral dimer interface [polypeptide binding]; other site 386585014029 L10 interface [polypeptide binding]; other site 386585014030 L11 interface [polypeptide binding]; other site 386585014031 putative EF-Tu interaction site [polypeptide binding]; other site 386585014032 putative EF-G interaction site [polypeptide binding]; other site 386585014033 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 386585014034 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 386585014035 RPB12 interaction site [polypeptide binding]; other site 386585014036 RPB1 interaction site [polypeptide binding]; other site 386585014037 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 386585014038 RPB10 interaction site [polypeptide binding]; other site 386585014039 RPB11 interaction site [polypeptide binding]; other site 386585014040 RPB3 interaction site [polypeptide binding]; other site 386585014041 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 386585014042 beta and beta' interface [polypeptide binding]; other site 386585014043 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 386585014044 beta' and sigma factor interface [polypeptide binding]; other site 386585014045 Zn-binding [ion binding]; other site 386585014046 active site region [active] 386585014047 catalytic site [active] 386585014048 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 386585014049 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 386585014050 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 386585014051 G-loop; other site 386585014052 DNA binding site [nucleotide binding] 386585014053 stationary phase growth adaptation protein; Provisional; Region: PRK09717 386585014054 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 386585014055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585014056 FeS/SAM binding site; other site 386585014057 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 386585014058 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 386585014059 ThiS interaction site; other site 386585014060 putative active site [active] 386585014061 tetramer interface [polypeptide binding]; other site 386585014062 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 386585014063 thiS-thiF/thiG interaction site; other site 386585014064 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 386585014065 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 386585014066 ATP binding site [chemical binding]; other site 386585014067 substrate interface [chemical binding]; other site 386585014068 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 386585014069 thiamine phosphate binding site [chemical binding]; other site 386585014070 active site 386585014071 pyrophosphate binding site [ion binding]; other site 386585014072 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 386585014073 ThiC-associated domain; Region: ThiC-associated; pfam13667 386585014074 ThiC family; Region: ThiC; pfam01964 386585014075 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 386585014076 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 386585014077 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 386585014078 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 386585014079 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 386585014080 putative NADH binding site [chemical binding]; other site 386585014081 putative active site [active] 386585014082 nudix motif; other site 386585014083 putative metal binding site [ion binding]; other site 386585014084 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 386585014085 substrate binding site [chemical binding]; other site 386585014086 active site 386585014087 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 386585014088 Active_site [active] 386585014089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 386585014090 histone-like DNA-binding protein HU; Region: HU; cd13831 386585014091 dimer interface [polypeptide binding]; other site 386585014092 DNA binding site [nucleotide binding] 386585014093 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 386585014094 zinc resistance protein; Provisional; Region: zraP; PRK11546 386585014095 dimer interface [polypeptide binding]; other site 386585014096 sensor protein ZraS; Provisional; Region: PRK10364 386585014097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585014098 dimer interface [polypeptide binding]; other site 386585014099 phosphorylation site [posttranslational modification] 386585014100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585014101 ATP binding site [chemical binding]; other site 386585014102 Mg2+ binding site [ion binding]; other site 386585014103 G-X-G motif; other site 386585014104 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 386585014105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585014106 active site 386585014107 phosphorylation site [posttranslational modification] 386585014108 intermolecular recognition site; other site 386585014109 dimerization interface [polypeptide binding]; other site 386585014110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585014111 Walker A motif; other site 386585014112 ATP binding site [chemical binding]; other site 386585014113 Walker B motif; other site 386585014114 arginine finger; other site 386585014115 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 386585014116 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 386585014117 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 386585014118 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 386585014119 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 386585014120 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 386585014121 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 386585014122 purine monophosphate binding site [chemical binding]; other site 386585014123 dimer interface [polypeptide binding]; other site 386585014124 putative catalytic residues [active] 386585014125 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 386585014126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 386585014127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585014128 Coenzyme A binding pocket [chemical binding]; other site 386585014129 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 386585014130 proposed active site lysine [active] 386585014131 conserved cys residue [active] 386585014132 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 386585014133 active site 386585014134 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 386585014135 tetramer interface [polypeptide binding]; other site 386585014136 active site 386585014137 Mg2+/Mn2+ binding site [ion binding]; other site 386585014138 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 386585014139 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 386585014140 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 386585014141 transcriptional repressor IclR; Provisional; Region: PRK11569 386585014142 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 386585014143 Bacterial transcriptional regulator; Region: IclR; pfam01614 386585014144 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 386585014145 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 386585014146 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 386585014147 substrate binding pocket [chemical binding]; other site 386585014148 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 386585014149 B12 binding site [chemical binding]; other site 386585014150 cobalt ligand [ion binding]; other site 386585014151 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 386585014152 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 386585014153 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 386585014154 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 386585014155 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 386585014156 active site pocket [active] 386585014157 oxyanion hole [active] 386585014158 catalytic triad [active] 386585014159 active site nucleophile [active] 386585014160 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 386585014161 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 386585014162 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585014163 putative NAD(P) binding site [chemical binding]; other site 386585014164 catalytic Zn binding site [ion binding]; other site 386585014165 similar to PTS system, sorbose-permease IID component; disrupted by frameshift 386585014166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585014167 non-specific DNA binding site [nucleotide binding]; other site 386585014168 salt bridge; other site 386585014169 sequence-specific DNA binding site [nucleotide binding]; other site 386585014170 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 386585014171 Integrase core domain; Region: rve; pfam00665 386585014172 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 386585014173 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 386585014174 AAA domain; Region: AAA_22; pfam13401 386585014175 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 386585014176 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 386585014177 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 386585014178 Mu-like prophage host-nuclease inhibitor protein Gam [General function prediction only]; Region: COG4396 386585014179 hypothetical protein; Region: PHA00675 386585014180 Mu-like prophage protein gp16 [Function unknown]; Region: COG4382 386585014181 Uncharacterized conserved protein [Function unknown]; Region: COG5566 386585014182 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 386585014183 catalytic residues [active] 386585014184 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 386585014185 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 386585014186 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 386585014187 putative DNA binding helix; other site 386585014188 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 386585014189 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 386585014190 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 386585014191 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 386585014192 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 386585014193 Mu-like prophage protein gpG [General function prediction only]; Region: COG5005 386585014194 Mu-like prophage I protein [General function prediction only]; Region: COG4388 386585014195 Mu-like prophage major head subunit gpT [General function prediction only]; Region: COG4397 386585014196 Mu-like prophage protein gp36 [Function unknown]; Region: COG4387 386585014197 Mu-like prophage protein gp37 [General function prediction only]; Region: COG5003 386585014198 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 386585014199 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 386585014200 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 386585014201 Phage tail tube protein; Region: Tail_tube; pfam10618 386585014202 Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518 386585014203 Mu-like prophage protein [General function prediction only]; Region: COG3941 386585014204 tape measure domain; Region: tape_meas_nterm; TIGR02675 386585014205 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 386585014206 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 386585014207 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 386585014208 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 386585014209 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 386585014210 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 386585014211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 386585014212 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 386585014213 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 386585014214 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 386585014215 catalytic residues [active] 386585014216 catalytic nucleophile [active] 386585014217 Presynaptic Site I dimer interface [polypeptide binding]; other site 386585014218 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 386585014219 Synaptic Flat tetramer interface [polypeptide binding]; other site 386585014220 Synaptic Site I dimer interface [polypeptide binding]; other site 386585014221 DNA binding site [nucleotide binding] 386585014222 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 386585014223 DNA-binding interface [nucleotide binding]; DNA binding site 386585014224 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585014225 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 386585014226 Protein of unknown function (DUF826); Region: DUF826; pfam05696 386585014227 Mu-like prophage protein Com [General function prediction only]; Region: Com; COG4416 386585014228 similar to sorbose-permease PTS system IID component; interupted by phage integration 386585014229 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 386585014230 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 386585014231 active site 386585014232 phosphorylation site [posttranslational modification] 386585014233 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 386585014234 active pocket/dimerization site; other site 386585014235 active site 386585014236 phosphorylation site [posttranslational modification] 386585014237 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 386585014238 classical (c) SDRs; Region: SDR_c; cd05233 386585014239 NAD(P) binding site [chemical binding]; other site 386585014240 active site 386585014241 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 386585014242 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 386585014243 putative DNA binding site [nucleotide binding]; other site 386585014244 putative Zn2+ binding site [ion binding]; other site 386585014245 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 386585014246 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 386585014247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 386585014248 RNA binding surface [nucleotide binding]; other site 386585014249 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 386585014250 probable active site [active] 386585014251 hypothetical protein; Provisional; Region: PRK10515 386585014252 aspartate kinase III; Validated; Region: PRK09084 386585014253 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 386585014254 nucleotide binding site [chemical binding]; other site 386585014255 putative catalytic residues [active] 386585014256 aspartate binding site [chemical binding]; other site 386585014257 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 386585014258 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 386585014259 dimer interface [polypeptide binding]; other site 386585014260 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 386585014261 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 386585014262 active site 386585014263 dimer interface [polypeptide binding]; other site 386585014264 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 386585014265 dimer interface [polypeptide binding]; other site 386585014266 active site 386585014267 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 386585014268 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 386585014269 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 386585014270 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 386585014271 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 386585014272 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 386585014273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585014274 putative substrate translocation pore; other site 386585014275 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 386585014276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585014277 dimer interface [polypeptide binding]; other site 386585014278 conserved gate region; other site 386585014279 putative PBP binding loops; other site 386585014280 ABC-ATPase subunit interface; other site 386585014281 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 386585014282 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 386585014283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585014284 dimer interface [polypeptide binding]; other site 386585014285 conserved gate region; other site 386585014286 putative PBP binding loops; other site 386585014287 ABC-ATPase subunit interface; other site 386585014288 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 386585014289 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 386585014290 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 386585014291 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 386585014292 Walker A/P-loop; other site 386585014293 ATP binding site [chemical binding]; other site 386585014294 Q-loop/lid; other site 386585014295 ABC transporter signature motif; other site 386585014296 Walker B; other site 386585014297 D-loop; other site 386585014298 H-loop/switch region; other site 386585014299 TOBE domain; Region: TOBE_2; pfam08402 386585014300 maltoporin; Provisional; Region: lamB; PRK09360 386585014301 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 386585014302 trimer interface; other site 386585014303 sugar binding site [chemical binding]; other site 386585014304 maltose regulon periplasmic protein; Provisional; Region: PRK10564 386585014305 hypothetical protein; Validated; Region: PRK09718 386585014306 SopA-like central domain; Region: SopA; pfam13981 386585014307 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 386585014308 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 386585014309 putative active site [active] 386585014310 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 386585014311 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 386585014312 putative acyl-acceptor binding pocket; other site 386585014313 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 386585014314 putative active site [active] 386585014315 trimer interface [polypeptide binding]; other site 386585014316 putative active site [active] 386585014317 Zn binding site [ion binding]; other site 386585014318 LexA repressor; Validated; Region: PRK00215 386585014319 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 386585014320 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 386585014321 Catalytic site [active] 386585014322 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 386585014323 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 386585014324 hypothetical protein; Provisional; Region: PRK10428 386585014325 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 386585014326 metal binding site 2 [ion binding]; metal-binding site 386585014327 putative DNA binding helix; other site 386585014328 metal binding site 1 [ion binding]; metal-binding site 386585014329 dimer interface [polypeptide binding]; other site 386585014330 structural Zn2+ binding site [ion binding]; other site 386585014331 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 386585014332 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 386585014333 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 386585014334 FMN binding site [chemical binding]; other site 386585014335 active site 386585014336 catalytic residues [active] 386585014337 substrate binding site [chemical binding]; other site 386585014338 phage shock protein G; Reviewed; Region: pspG; PRK09459 386585014339 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 386585014340 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 386585014341 NADP binding site [chemical binding]; other site 386585014342 dimer interface [polypeptide binding]; other site 386585014343 replicative DNA helicase; Provisional; Region: PRK08006 386585014344 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 386585014345 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 386585014346 Walker A motif; other site 386585014347 ATP binding site [chemical binding]; other site 386585014348 Walker B motif; other site 386585014349 DNA binding loops [nucleotide binding] 386585014350 alanine racemase; Reviewed; Region: alr; PRK00053 386585014351 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 386585014352 active site 386585014353 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 386585014354 substrate binding site [chemical binding]; other site 386585014355 catalytic residues [active] 386585014356 dimer interface [polypeptide binding]; other site 386585014357 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 386585014358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585014359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585014360 homodimer interface [polypeptide binding]; other site 386585014361 catalytic residue [active] 386585014362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585014363 active site 386585014364 motif I; other site 386585014365 motif II; other site 386585014366 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 386585014367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 386585014368 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 386585014369 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 386585014370 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 386585014371 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 386585014372 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 386585014373 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 386585014374 dimer interface [polypeptide binding]; other site 386585014375 ssDNA binding site [nucleotide binding]; other site 386585014376 tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585014377 putative single-stranded DNA-binding protein; Region: PHA01740 386585014378 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 386585014379 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 386585014380 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 386585014381 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 386585014382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585014383 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 386585014384 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 386585014385 DNA binding residues [nucleotide binding] 386585014386 dimer interface [polypeptide binding]; other site 386585014387 [2Fe-2S] cluster binding site [ion binding]; other site 386585014388 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 386585014389 Sulfate transporter family; Region: Sulfate_transp; cl19250 386585014390 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 386585014391 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 386585014392 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 386585014393 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585014394 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585014395 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 386585014396 Na binding site [ion binding]; other site 386585014397 Predicted membrane protein [Function unknown]; Region: COG3162 386585014398 acetyl-CoA synthetase; Provisional; Region: PRK00174 386585014399 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 386585014400 active site 386585014401 CoA binding site [chemical binding]; other site 386585014402 acyl-activating enzyme (AAE) consensus motif; other site 386585014403 AMP binding site [chemical binding]; other site 386585014404 acetate binding site [chemical binding]; other site 386585014405 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 386585014406 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 386585014407 Cytochrome c7; Region: Cytochrome_C7; cl19206 386585014408 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 386585014409 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 386585014410 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 386585014411 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 386585014412 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 386585014413 heme lyase subunit NrfE; Provisional; Region: PRK10369 386585014414 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 386585014415 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 386585014416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 386585014417 binding surface 386585014418 TPR motif; other site 386585014419 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 386585014420 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 386585014421 Sel1-like repeats; Region: SEL1; smart00671 386585014422 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 386585014423 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 386585014424 [4Fe-4S] binding site [ion binding]; other site 386585014425 molybdopterin cofactor binding site; other site 386585014426 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 386585014427 molybdopterin cofactor binding site; other site 386585014428 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 386585014429 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 386585014430 Outer membrane efflux protein; Region: OEP; pfam02321 386585014431 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 386585014432 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 386585014433 multidrug resistance protein MdtN; Provisional; Region: PRK10476 386585014434 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 386585014435 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 386585014436 HlyD family secretion protein; Region: HlyD_3; pfam13437 386585014437 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 386585014438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 386585014439 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 386585014440 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 386585014441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 386585014442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585014443 active site 386585014444 phosphorylation site [posttranslational modification] 386585014445 intermolecular recognition site; other site 386585014446 dimerization interface [polypeptide binding]; other site 386585014447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585014448 DNA binding site [nucleotide binding] 386585014449 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 386585014450 substrate binding site [chemical binding]; other site 386585014451 ATP binding site [chemical binding]; other site 386585014452 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 386585014453 intersubunit interface [polypeptide binding]; other site 386585014454 active site 386585014455 zinc binding site [ion binding]; other site 386585014456 Na+ binding site [ion binding]; other site 386585014457 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 386585014458 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 386585014459 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 386585014460 putative ligand binding site [chemical binding]; other site 386585014461 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585014462 TM-ABC transporter signature motif; other site 386585014463 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 386585014464 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585014465 Walker A/P-loop; other site 386585014466 ATP binding site [chemical binding]; other site 386585014467 Q-loop/lid; other site 386585014468 ABC transporter signature motif; other site 386585014469 Walker B; other site 386585014470 D-loop; other site 386585014471 H-loop/switch region; other site 386585014472 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585014473 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 386585014474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585014475 dimerization interface [polypeptide binding]; other site 386585014476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585014477 dimer interface [polypeptide binding]; other site 386585014478 phosphorylation site [posttranslational modification] 386585014479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585014480 ATP binding site [chemical binding]; other site 386585014481 Mg2+ binding site [ion binding]; other site 386585014482 G-X-G motif; other site 386585014483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585014484 active site 386585014485 phosphorylation site [posttranslational modification] 386585014486 intermolecular recognition site; other site 386585014487 dimerization interface [polypeptide binding]; other site 386585014488 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 386585014489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585014490 Coenzyme A binding pocket [chemical binding]; other site 386585014491 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 386585014492 Guanylate kinase; Region: Guanylate_kin; pfam00625 386585014493 active site 386585014494 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 386585014495 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 386585014496 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 386585014497 active site 386585014498 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 386585014499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 386585014500 Walker A/P-loop; other site 386585014501 ATP binding site [chemical binding]; other site 386585014502 Q-loop/lid; other site 386585014503 ABC transporter signature motif; other site 386585014504 Walker B; other site 386585014505 D-loop; other site 386585014506 H-loop/switch region; other site 386585014507 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 386585014508 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 386585014509 Walker A/P-loop; other site 386585014510 ATP binding site [chemical binding]; other site 386585014511 Q-loop/lid; other site 386585014512 ABC transporter signature motif; other site 386585014513 Walker B; other site 386585014514 D-loop; other site 386585014515 H-loop/switch region; other site 386585014516 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 386585014517 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 386585014518 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 386585014519 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 386585014520 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 386585014521 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 386585014522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585014523 DNA-binding site [nucleotide binding]; DNA binding site 386585014524 UTRA domain; Region: UTRA; pfam07702 386585014525 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 386585014526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 386585014527 dimer interface [polypeptide binding]; other site 386585014528 conserved gate region; other site 386585014529 putative PBP binding loops; other site 386585014530 ABC-ATPase subunit interface; other site 386585014531 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 386585014532 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 386585014533 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 386585014534 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 386585014535 Walker A/P-loop; other site 386585014536 ATP binding site [chemical binding]; other site 386585014537 Q-loop/lid; other site 386585014538 ABC transporter signature motif; other site 386585014539 Walker B; other site 386585014540 D-loop; other site 386585014541 H-loop/switch region; other site 386585014542 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 386585014543 dimer interface [polypeptide binding]; other site 386585014544 hypothetical protein; Provisional; Region: PRK10220 386585014545 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 386585014546 PhnA protein; Region: PhnA; pfam03831 386585014547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 386585014548 G1 box; other site 386585014549 GTP/Mg2+ binding site [chemical binding]; other site 386585014550 G2 box; other site 386585014551 Switch I region; other site 386585014552 G3 box; other site 386585014553 Switch II region; other site 386585014554 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 386585014555 G2 box; other site 386585014556 Switch I region; other site 386585014557 G3 box; other site 386585014558 Switch II region; other site 386585014559 G4 box; other site 386585014560 G5 box; other site 386585014561 YjcZ-like protein; Region: YjcZ; pfam13990 386585014562 proline/glycine betaine transporter; Provisional; Region: PRK10642 386585014563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585014564 putative substrate translocation pore; other site 386585014565 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 386585014566 sensor protein BasS/PmrB; Provisional; Region: PRK10755 386585014567 HAMP domain; Region: HAMP; pfam00672 386585014568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585014569 dimer interface [polypeptide binding]; other site 386585014570 phosphorylation site [posttranslational modification] 386585014571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585014572 ATP binding site [chemical binding]; other site 386585014573 Mg2+ binding site [ion binding]; other site 386585014574 G-X-G motif; other site 386585014575 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 386585014576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585014577 active site 386585014578 phosphorylation site [posttranslational modification] 386585014579 intermolecular recognition site; other site 386585014580 dimerization interface [polypeptide binding]; other site 386585014581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585014582 DNA binding site [nucleotide binding] 386585014583 putative metal dependent hydrolase; Provisional; Region: PRK11598 386585014584 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 386585014585 Sulfatase; Region: Sulfatase; pfam00884 386585014586 arginine:agmatin antiporter; Provisional; Region: PRK10644 386585014587 Spore germination protein; Region: Spore_permease; cl17796 386585014588 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585014589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585014590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 386585014591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585014592 arginine decarboxylase; Provisional; Region: PRK15029 386585014593 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 386585014594 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 386585014595 homodimer interface [polypeptide binding]; other site 386585014596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585014597 catalytic residue [active] 386585014598 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 386585014599 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 386585014600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585014601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585014602 alpha-galactosidase; Provisional; Region: PRK15076 386585014603 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 386585014604 NAD binding site [chemical binding]; other site 386585014605 sugar binding site [chemical binding]; other site 386585014606 divalent metal binding site [ion binding]; other site 386585014607 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585014608 dimer interface [polypeptide binding]; other site 386585014609 melibiose:sodium symporter; Provisional; Region: PRK10429 386585014610 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 386585014611 hypothetical protein; Provisional; Region: PRK09867 386585014612 fumarate hydratase FumB; Provisional; Region: PRK15391 386585014613 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 386585014614 Fumarase C-terminus; Region: Fumerase_C; pfam05683 386585014615 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 386585014616 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 386585014617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585014618 active site 386585014619 phosphorylation site [posttranslational modification] 386585014620 intermolecular recognition site; other site 386585014621 dimerization interface [polypeptide binding]; other site 386585014622 sensory histidine kinase DcuS; Provisional; Region: PRK11086 386585014623 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 386585014624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 386585014625 putative active site [active] 386585014626 heme pocket [chemical binding]; other site 386585014627 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 386585014628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585014629 ATP binding site [chemical binding]; other site 386585014630 Mg2+ binding site [ion binding]; other site 386585014631 G-X-G motif; other site 386585014632 Uncharacterized conserved protein [Function unknown]; Region: COG3592 386585014633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585014634 Coenzyme A binding pocket [chemical binding]; other site 386585014635 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 386585014636 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 386585014637 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 386585014638 dimer interface [polypeptide binding]; other site 386585014639 putative anticodon binding site; other site 386585014640 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 386585014641 motif 1; other site 386585014642 active site 386585014643 motif 2; other site 386585014644 motif 3; other site 386585014645 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 386585014646 POT family; Region: PTR2; cl17359 386585014647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585014648 putative substrate translocation pore; other site 386585014649 lysine decarboxylase CadA; Provisional; Region: PRK15400 386585014650 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 386585014651 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 386585014652 homodimer interface [polypeptide binding]; other site 386585014653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585014654 catalytic residue [active] 386585014655 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 386585014656 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 386585014657 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 386585014658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585014659 DNA binding site [nucleotide binding] 386585014660 putative transcriptional regulator; Provisional; Region: PRK11640 386585014661 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 386585014662 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 386585014663 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 386585014664 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 386585014665 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 386585014666 DsbD alpha interface [polypeptide binding]; other site 386585014667 catalytic residues [active] 386585014668 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 386585014669 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 386585014670 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 386585014671 Aspartase; Region: Aspartase; cd01357 386585014672 active sites [active] 386585014673 tetramer interface [polypeptide binding]; other site 386585014674 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 386585014675 putative transporter; Provisional; Region: PRK11021 386585014676 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585014677 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 386585014678 oligomerisation interface [polypeptide binding]; other site 386585014679 mobile loop; other site 386585014680 roof hairpin; other site 386585014681 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 386585014682 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 386585014683 ring oligomerisation interface [polypeptide binding]; other site 386585014684 ATP/Mg binding site [chemical binding]; other site 386585014685 stacking interactions; other site 386585014686 hinge regions; other site 386585014687 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 386585014688 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 386585014689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585014690 FeS/SAM binding site; other site 386585014691 elongation factor P; Validated; Region: PRK00529 386585014692 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 386585014693 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 386585014694 RNA binding site [nucleotide binding]; other site 386585014695 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 386585014696 RNA binding site [nucleotide binding]; other site 386585014697 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 386585014698 multidrug efflux system protein; Provisional; Region: PRK11431 386585014699 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 386585014700 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 386585014701 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 386585014702 Iron-sulfur protein interface; other site 386585014703 proximal quinone binding site [chemical binding]; other site 386585014704 C-subunit interface; other site 386585014705 distal quinone binding site; other site 386585014706 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 386585014707 D-subunit interface [polypeptide binding]; other site 386585014708 Iron-sulfur protein interface; other site 386585014709 proximal quinone binding site [chemical binding]; other site 386585014710 distal quinone binding site [chemical binding]; other site 386585014711 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 386585014712 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 386585014713 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 386585014714 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 386585014715 L-aspartate oxidase; Provisional; Region: PRK06175 386585014716 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 386585014717 poxB regulator PoxA; Provisional; Region: PRK09350 386585014718 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 386585014719 motif 1; other site 386585014720 dimer interface [polypeptide binding]; other site 386585014721 active site 386585014722 motif 2; other site 386585014723 motif 3; other site 386585014724 inner membrane transporter YjeM; Provisional; Region: PRK15238 386585014725 putative mechanosensitive channel protein; Provisional; Region: PRK10929 386585014726 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 386585014727 DNA-binding site [nucleotide binding]; DNA binding site 386585014728 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 386585014729 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 386585014730 Mechanosensitive ion channel; Region: MS_channel; pfam00924 386585014731 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 386585014732 GTPase RsgA; Reviewed; Region: PRK12288 386585014733 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 386585014734 RNA binding site [nucleotide binding]; other site 386585014735 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 386585014736 GTPase/Zn-binding domain interface [polypeptide binding]; other site 386585014737 GTP/Mg2+ binding site [chemical binding]; other site 386585014738 G4 box; other site 386585014739 G5 box; other site 386585014740 G1 box; other site 386585014741 Switch I region; other site 386585014742 G2 box; other site 386585014743 G3 box; other site 386585014744 Switch II region; other site 386585014745 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 386585014746 catalytic site [active] 386585014747 putative active site [active] 386585014748 putative substrate binding site [chemical binding]; other site 386585014749 dimer interface [polypeptide binding]; other site 386585014750 epoxyqueuosine reductase; Region: TIGR00276 386585014751 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 386585014752 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 386585014753 putative carbohydrate kinase; Provisional; Region: PRK10565 386585014754 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 386585014755 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 386585014756 putative substrate binding site [chemical binding]; other site 386585014757 putative ATP binding site [chemical binding]; other site 386585014758 ADP-binding protein; Provisional; Region: PRK10646 386585014759 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 386585014760 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 386585014761 AMIN domain; Region: AMIN; pfam11741 386585014762 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 386585014763 active site 386585014764 metal binding site [ion binding]; metal-binding site 386585014765 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 386585014766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585014767 ATP binding site [chemical binding]; other site 386585014768 Mg2+ binding site [ion binding]; other site 386585014769 G-X-G motif; other site 386585014770 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 386585014771 ATP binding site [chemical binding]; other site 386585014772 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 386585014773 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 386585014774 bacterial Hfq-like; Region: Hfq; cd01716 386585014775 hexamer interface [polypeptide binding]; other site 386585014776 Sm1 motif; other site 386585014777 RNA binding site [nucleotide binding]; other site 386585014778 Sm2 motif; other site 386585014779 GTPase HflX; Provisional; Region: PRK11058 386585014780 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 386585014781 HflX GTPase family; Region: HflX; cd01878 386585014782 G1 box; other site 386585014783 GTP/Mg2+ binding site [chemical binding]; other site 386585014784 Switch I region; other site 386585014785 G2 box; other site 386585014786 G3 box; other site 386585014787 Switch II region; other site 386585014788 G4 box; other site 386585014789 G5 box; other site 386585014790 FtsH protease regulator HflK; Provisional; Region: PRK10930 386585014791 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 386585014792 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 386585014793 HflC protein; Region: hflC; TIGR01932 386585014794 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 386585014795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 386585014796 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 386585014797 GDP-binding site [chemical binding]; other site 386585014798 ACT binding site; other site 386585014799 IMP binding site; other site 386585014800 transcriptional repressor NsrR; Provisional; Region: PRK11014 386585014801 Rrf2 family protein; Region: rrf2_super; TIGR00738 386585014802 exoribonuclease R; Provisional; Region: PRK11642 386585014803 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 386585014804 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 386585014805 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 386585014806 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 386585014807 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 386585014808 RNA binding site [nucleotide binding]; other site 386585014809 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 386585014810 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 386585014811 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 386585014812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 386585014813 PspA/IM30 family; Region: PspA_IM30; pfam04012 386585014814 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 386585014815 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 386585014816 Predicted membrane protein [Function unknown]; Region: COG3766 386585014817 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 386585014818 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 386585014819 Predicted integral membrane protein [Function unknown]; Region: COG5463 386585014820 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 386585014821 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 386585014822 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 386585014823 FAD binding site [chemical binding]; other site 386585014824 substrate binding site [chemical binding]; other site 386585014825 catalytic residues [active] 386585014826 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585014827 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 386585014828 esterase; Provisional; Region: PRK10566 386585014829 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 386585014830 transcriptional repressor UlaR; Provisional; Region: PRK13509 386585014831 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 386585014832 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 386585014833 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 386585014834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 386585014835 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 386585014836 active site 386585014837 P-loop; other site 386585014838 phosphorylation site [posttranslational modification] 386585014839 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 386585014840 active site 386585014841 phosphorylation site [posttranslational modification] 386585014842 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 386585014843 active site 386585014844 dimer interface [polypeptide binding]; other site 386585014845 magnesium binding site [ion binding]; other site 386585014846 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 386585014847 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 386585014848 AP (apurinic/apyrimidinic) site pocket; other site 386585014849 DNA interaction; other site 386585014850 Metal-binding active site; metal-binding site 386585014851 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 386585014852 intersubunit interface [polypeptide binding]; other site 386585014853 active site 386585014854 Zn2+ binding site [ion binding]; other site 386585014855 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 386585014856 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 386585014857 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 386585014858 dimer interface [polypeptide binding]; other site 386585014859 ssDNA binding site [nucleotide binding]; other site 386585014860 tetramer (dimer of dimers) interface [polypeptide binding]; other site 386585014861 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 386585014862 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 386585014863 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 386585014864 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 386585014865 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 386585014866 Transposase IS200 like; Region: Y1_Tnp; pfam01797 386585014867 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 386585014868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 386585014869 Probable transposase; Region: OrfB_IS605; pfam01385 386585014870 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 386585014871 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 386585014872 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 386585014873 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 386585014874 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 386585014875 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 386585014876 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 386585014877 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 386585014878 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 386585014879 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 386585014880 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 386585014881 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 386585014882 Fe binding site [ion binding]; other site 386585014883 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 386585014884 EamA-like transporter family; Region: EamA; pfam00892 386585014885 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 386585014886 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 386585014887 NADP binding site [chemical binding]; other site 386585014888 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 386585014889 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 386585014890 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 386585014891 active site 386585014892 metal binding site [ion binding]; metal-binding site 386585014893 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 386585014894 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 386585014895 active site 386585014896 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 386585014897 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 386585014898 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 386585014899 Domain of unknown function DUF21; Region: DUF21; pfam01595 386585014900 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 386585014901 Transporter associated domain; Region: CorC_HlyC; smart01091 386585014902 methionine sulfoxide reductase A; Provisional; Region: PRK00058 386585014903 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 386585014904 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585014905 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 386585014906 Surface antigen; Region: Bac_surface_Ag; pfam01103 386585014907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 386585014908 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 386585014909 Family of unknown function (DUF490); Region: DUF490; pfam04357 386585014910 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 386585014911 putative active site pocket [active] 386585014912 dimerization interface [polypeptide binding]; other site 386585014913 putative catalytic residue [active] 386585014914 hypothetical protein; Provisional; Region: PRK09719 386585014915 antitoxin ChpS; Provisional; Region: PRK11347 386585014916 toxin ChpB; Provisional; Region: PRK09812 386585014917 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 386585014918 dimer interface [polypeptide binding]; other site 386585014919 substrate binding site [chemical binding]; other site 386585014920 metal binding sites [ion binding]; metal-binding site 386585014921 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 386585014922 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 386585014923 putative ligand binding site [chemical binding]; other site 386585014924 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 386585014925 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 386585014926 Walker A/P-loop; other site 386585014927 ATP binding site [chemical binding]; other site 386585014928 Q-loop/lid; other site 386585014929 ABC transporter signature motif; other site 386585014930 Walker B; other site 386585014931 D-loop; other site 386585014932 H-loop/switch region; other site 386585014933 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 386585014934 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585014935 TM-ABC transporter signature motif; other site 386585014936 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 386585014937 TM-ABC transporter signature motif; other site 386585014938 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 386585014939 AMP binding site [chemical binding]; other site 386585014940 metal binding site [ion binding]; metal-binding site 386585014941 active site 386585014942 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 386585014943 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 386585014944 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 386585014945 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 386585014946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 386585014947 peptidase PmbA; Provisional; Region: PRK11040 386585014948 cytochrome b562; Provisional; Region: PRK15058 386585014949 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 386585014950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585014951 FeS/SAM binding site; other site 386585014952 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 386585014953 ATP cone domain; Region: ATP-cone; pfam03477 386585014954 Class III ribonucleotide reductase; Region: RNR_III; cd01675 386585014955 effector binding site; other site 386585014956 active site 386585014957 Zn binding site [ion binding]; other site 386585014958 glycine loop; other site 386585014959 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 386585014960 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 386585014961 Ca binding site [ion binding]; other site 386585014962 active site 386585014963 catalytic site [active] 386585014964 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 386585014965 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 386585014966 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 386585014967 active site turn [active] 386585014968 phosphorylation site [posttranslational modification] 386585014969 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 386585014970 trehalose repressor; Provisional; Region: treR; PRK09492 386585014971 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 386585014972 DNA binding site [nucleotide binding] 386585014973 domain linker motif; other site 386585014974 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 386585014975 dimerization interface [polypeptide binding]; other site 386585014976 ligand binding site [chemical binding]; other site 386585014977 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 386585014978 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 386585014979 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 386585014980 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 386585014981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585014982 motif II; other site 386585014983 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 386585014984 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 386585014985 homotrimer interaction site [polypeptide binding]; other site 386585014986 putative active site [active] 386585014987 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 386585014988 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 386585014989 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 386585014990 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 386585014991 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 386585014992 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 386585014993 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 386585014994 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 386585014995 homotrimer interaction site [polypeptide binding]; other site 386585014996 putative active site [active] 386585014997 oxidoreductase; Provisional; Region: PRK12742 386585014998 classical (c) SDRs; Region: SDR_c; cd05233 386585014999 NAD(P) binding site [chemical binding]; other site 386585015000 active site 386585015001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 386585015002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 386585015003 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 386585015004 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 386585015005 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 386585015006 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 386585015007 RNase E inhibitor protein; Provisional; Region: PRK11191 386585015008 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 386585015009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585015010 Coenzyme A binding pocket [chemical binding]; other site 386585015011 Predicted membrane protein [Function unknown]; Region: COG4269 386585015012 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 386585015013 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 386585015014 active site 386585015015 HIGH motif; other site 386585015016 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 386585015017 KMSKS motif; other site 386585015018 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 386585015019 tRNA binding surface [nucleotide binding]; other site 386585015020 anticodon binding site; other site 386585015021 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 386585015022 DNA polymerase III subunit chi; Validated; Region: PRK05728 386585015023 multifunctional aminopeptidase A; Provisional; Region: PRK00913 386585015024 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 386585015025 interface (dimer of trimers) [polypeptide binding]; other site 386585015026 Substrate-binding/catalytic site; other site 386585015027 Zn-binding sites [ion binding]; other site 386585015028 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 386585015029 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 386585015030 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 386585015031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585015032 Walker A motif; other site 386585015033 ATP binding site [chemical binding]; other site 386585015034 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 386585015035 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 386585015036 putative NAD(P) binding site [chemical binding]; other site 386585015037 putative substrate binding site [chemical binding]; other site 386585015038 catalytic Zn binding site [ion binding]; other site 386585015039 structural Zn binding site [ion binding]; other site 386585015040 dimer interface [polypeptide binding]; other site 386585015041 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 386585015042 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 386585015043 Int/Topo IB signature motif; other site 386585015044 Transposase; Region: HTH_Tnp_1; cl17663 386585015045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 386585015046 putative transposase OrfB; Reviewed; Region: PHA02517 386585015047 HTH-like domain; Region: HTH_21; pfam13276 386585015048 Integrase core domain; Region: rve; pfam00665 386585015049 Integrase core domain; Region: rve_3; pfam13683 386585015050 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 386585015051 NIPSNAP; Region: NIPSNAP; pfam07978 386585015052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 386585015053 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 386585015054 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 386585015055 catalytic residues [active] 386585015056 catalytic nucleophile [active] 386585015057 Presynaptic Site I dimer interface [polypeptide binding]; other site 386585015058 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 386585015059 Synaptic Flat tetramer interface [polypeptide binding]; other site 386585015060 Synaptic Site I dimer interface [polypeptide binding]; other site 386585015061 DNA binding site [nucleotide binding] 386585015062 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 386585015063 DNA-binding interface [nucleotide binding]; DNA binding site 386585015064 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 386585015065 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585015066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585015067 non-specific DNA binding site [nucleotide binding]; other site 386585015068 salt bridge; other site 386585015069 sequence-specific DNA binding site [nucleotide binding]; other site 386585015070 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 386585015071 Transposase; Region: HTH_Tnp_1; cl17663 386585015072 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 386585015073 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585015074 active site 386585015075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 386585015076 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 386585015077 active site 386585015078 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 386585015079 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 386585015080 ligand binding site [chemical binding]; other site 386585015081 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 386585015082 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 386585015083 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 386585015084 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 386585015085 Capsid triplex subunit 2; Provisional; Region: PHA03259 386585015086 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 386585015087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585015088 ATP binding site [chemical binding]; other site 386585015089 putative Mg++ binding site [ion binding]; other site 386585015090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585015091 nucleotide binding region [chemical binding]; other site 386585015092 ATP-binding site [chemical binding]; other site 386585015093 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 386585015094 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 386585015095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585015096 ATP binding site [chemical binding]; other site 386585015097 putative Mg++ binding site [ion binding]; other site 386585015098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585015099 nucleotide binding region [chemical binding]; other site 386585015100 ATP-binding site [chemical binding]; other site 386585015101 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 386585015102 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 386585015103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585015104 ATP binding site [chemical binding]; other site 386585015105 putative Mg++ binding site [ion binding]; other site 386585015106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 386585015107 ATP-binding site [chemical binding]; other site 386585015108 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 386585015109 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 386585015110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585015111 ATP binding site [chemical binding]; other site 386585015112 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 386585015113 Domain of unknown function (DUF303); Region: DUF303; pfam03629 386585015114 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 386585015115 Kelch motif; Region: Kelch_1; pfam01344 386585015116 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 386585015117 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 386585015118 Int/Topo IB signature motif; other site 386585015119 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 386585015120 Int/Topo IB signature motif; other site 386585015121 Fimbrial protein; Region: Fimbrial; cl01416 386585015122 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585015123 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 386585015124 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 386585015125 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 386585015126 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 386585015127 PapC N-terminal domain; Region: PapC_N; pfam13954 386585015128 Outer membrane usher protein; Region: Usher; pfam00577 386585015129 PapC C-terminal domain; Region: PapC_C; pfam13953 386585015130 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585015131 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 386585015132 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 386585015133 mannosyl binding site [chemical binding]; other site 386585015134 Fimbrial protein; Region: Fimbrial; pfam00419 386585015135 fructuronate transporter; Provisional; Region: PRK10034 386585015136 GntP family permease; Region: GntP_permease; pfam02447 386585015137 mannonate dehydratase; Region: uxuA; TIGR00695 386585015138 mannonate dehydratase; Provisional; Region: PRK03906 386585015139 D-mannonate oxidoreductase; Provisional; Region: PRK15037 386585015140 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 386585015141 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 386585015142 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 386585015143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585015144 DNA-binding site [nucleotide binding]; DNA binding site 386585015145 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585015146 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 386585015147 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 386585015148 similar to YJIE_ECOLI gi|1790783; disrupted 386585015149 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 386585015150 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 386585015151 dimer interface [polypeptide binding]; other site 386585015152 active site 386585015153 hypothetical protein; Provisional; Region: PRK10519 386585015154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 386585015155 Nucleoside recognition; Region: Gate; pfam07670 386585015156 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 386585015157 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 386585015158 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 386585015159 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015160 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015161 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015162 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015163 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015164 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015165 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 386585015166 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 386585015167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585015168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 386585015169 putative substrate translocation pore; other site 386585015170 SdiA-regulated; Region: SdiA-regulated; cd09971 386585015171 putative active site [active] 386585015172 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 386585015173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585015174 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585015175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585015176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585015177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 386585015178 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 386585015179 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 386585015180 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 386585015181 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 386585015182 Predicted membrane protein [Function unknown]; Region: COG2733 386585015183 Protein of unknown function (DUF445); Region: DUF445; pfam04286 386585015184 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 386585015185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585015186 putative substrate translocation pore; other site 386585015187 Uncharacterized conserved protein [Function unknown]; Region: COG5464 386585015188 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 386585015189 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 386585015190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 386585015191 DNA-binding site [nucleotide binding]; DNA binding site 386585015192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 386585015193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 386585015194 homodimer interface [polypeptide binding]; other site 386585015195 catalytic residue [active] 386585015196 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 386585015197 Uncharacterized conserved protein [Function unknown]; Region: COG1479 386585015198 Uncharacterized conserved protein [Function unknown]; Region: COG1479 386585015199 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 386585015200 Uncharacterized conserved protein [Function unknown]; Region: COG3586 386585015201 endoribonuclease SymE; Provisional; Region: PRK13605 386585015202 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 386585015203 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 386585015204 HsdM N-terminal domain; Region: HsdM_N; pfam12161 386585015205 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 386585015206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585015207 S-adenosylmethionine binding site [chemical binding]; other site 386585015208 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 386585015209 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 386585015210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 386585015211 ATP binding site [chemical binding]; other site 386585015212 putative Mg++ binding site [ion binding]; other site 386585015213 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 386585015214 Protein of unknown function DUF262; Region: DUF262; pfam03235 386585015215 Uncharacterized conserved protein [Function unknown]; Region: COG1479 386585015216 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 386585015217 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 386585015218 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 386585015219 P-loop, Walker A motif; other site 386585015220 Base recognition motif; other site 386585015221 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 386585015222 Uncharacterized small protein [Function unknown]; Region: COG2879 386585015223 carbon starvation protein A; Provisional; Region: PRK15015 386585015224 Carbon starvation protein CstA; Region: CstA; pfam02554 386585015225 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 386585015226 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 386585015227 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 386585015228 dimer interface [polypeptide binding]; other site 386585015229 ligand binding site [chemical binding]; other site 386585015230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585015231 dimerization interface [polypeptide binding]; other site 386585015232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 386585015233 dimer interface [polypeptide binding]; other site 386585015234 putative CheW interface [polypeptide binding]; other site 386585015235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 386585015236 D-galactonate transporter; Region: 2A0114; TIGR00893 386585015237 putative substrate translocation pore; other site 386585015238 Transcriptional regulators [Transcription]; Region: GntR; COG1802 386585015239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 386585015240 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 386585015241 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 386585015242 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 386585015243 putative NAD(P) binding site [chemical binding]; other site 386585015244 catalytic Zn binding site [ion binding]; other site 386585015245 structural Zn binding site [ion binding]; other site 386585015246 phosphoglycerol transferase I; Provisional; Region: PRK03776 386585015247 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 386585015248 hypothetical protein; Provisional; Region: PRK11667 386585015249 DNA replication protein DnaC; Validated; Region: PRK07952 386585015250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 386585015251 Walker A motif; other site 386585015252 ATP binding site [chemical binding]; other site 386585015253 Walker B motif; other site 386585015254 primosomal protein DnaI; Provisional; Region: PRK02854 386585015255 hypothetical protein; Provisional; Region: PRK09917 386585015256 Uncharacterized conserved protein [Function unknown]; Region: COG2966 386585015257 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 386585015258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 386585015259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585015260 DNA binding residues [nucleotide binding] 386585015261 dimerization interface [polypeptide binding]; other site 386585015262 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 386585015263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 386585015264 DNA binding residues [nucleotide binding] 386585015265 dimerization interface [polypeptide binding]; other site 386585015266 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 386585015267 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 386585015268 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 386585015269 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 386585015270 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 386585015271 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 386585015272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 386585015273 S-adenosylmethionine binding site [chemical binding]; other site 386585015274 DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050 386585015275 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 386585015276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 386585015277 Coenzyme A binding pocket [chemical binding]; other site 386585015278 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 386585015279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585015280 motif II; other site 386585015281 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 386585015282 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 386585015283 G1 box; other site 386585015284 putative GEF interaction site [polypeptide binding]; other site 386585015285 GTP/Mg2+ binding site [chemical binding]; other site 386585015286 Switch I region; other site 386585015287 G2 box; other site 386585015288 G3 box; other site 386585015289 Switch II region; other site 386585015290 G4 box; other site 386585015291 G5 box; other site 386585015292 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 386585015293 Elongation Factor G, domain II; Region: EFG_II; pfam14492 386585015294 periplasmic protein; Provisional; Region: PRK10568 386585015295 BON domain; Region: BON; pfam04972 386585015296 BON domain; Region: BON; pfam04972 386585015297 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 386585015298 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 386585015299 active site 386585015300 nucleophile elbow; other site 386585015301 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 386585015302 active site 386585015303 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 386585015304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 386585015305 FeS/SAM binding site; other site 386585015306 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 386585015307 similar to YJJI_ECOLI gi|1790840; disrupted by frameshift 386585015308 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 386585015309 intersubunit interface [polypeptide binding]; other site 386585015310 active site 386585015311 catalytic residue [active] 386585015312 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 386585015313 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 386585015314 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 386585015315 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 386585015316 phosphopentomutase; Provisional; Region: PRK05362 386585015317 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 386585015318 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 386585015319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585015320 non-specific DNA binding site [nucleotide binding]; other site 386585015321 salt bridge; other site 386585015322 sequence-specific DNA binding site [nucleotide binding]; other site 386585015323 unknown domain/lipoate-protein ligase A fusion protein; Provisional; Region: PRK14061 386585015324 hypothetical protein; Provisional; Region: PRK11246 386585015325 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 386585015326 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 386585015327 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 386585015328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 386585015329 motif II; other site 386585015330 DNA repair protein RadA; Region: sms; TIGR00416 386585015331 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 386585015332 Walker A motif/ATP binding site; other site 386585015333 ATP binding site [chemical binding]; other site 386585015334 Walker B motif; other site 386585015335 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 386585015336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 386585015337 non-specific DNA binding site [nucleotide binding]; other site 386585015338 salt bridge; other site 386585015339 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 386585015340 sequence-specific DNA binding site [nucleotide binding]; other site 386585015341 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 386585015342 active site 386585015343 (T/H)XGH motif; other site 386585015344 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 386585015345 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 386585015346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585015347 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 386585015348 ABC transporter; Region: ABC_tran_2; pfam12848 386585015349 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 386585015350 lytic murein transglycosylase; Provisional; Region: PRK11619 386585015351 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 386585015352 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 386585015353 N-acetyl-D-glucosamine binding site [chemical binding]; other site 386585015354 catalytic residue [active] 386585015355 Trp operon repressor [Transcription]; Region: TrpR; COG2973 386585015356 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 386585015357 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 386585015358 catalytic core [active] 386585015359 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 386585015360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585015361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 386585015362 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 386585015363 hypothetical protein; Provisional; Region: PRK10756 386585015364 DNA-binding response regulator CreB; Provisional; Region: PRK11083 386585015365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585015366 active site 386585015367 phosphorylation site [posttranslational modification] 386585015368 intermolecular recognition site; other site 386585015369 dimerization interface [polypeptide binding]; other site 386585015370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585015371 DNA binding site [nucleotide binding] 386585015372 sensory histidine kinase CreC; Provisional; Region: PRK11100 386585015373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 386585015374 dimerization interface [polypeptide binding]; other site 386585015375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 386585015376 dimer interface [polypeptide binding]; other site 386585015377 phosphorylation site [posttranslational modification] 386585015378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 386585015379 ATP binding site [chemical binding]; other site 386585015380 Mg2+ binding site [ion binding]; other site 386585015381 G-X-G motif; other site 386585015382 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 386585015383 two-component response regulator; Provisional; Region: PRK11173 386585015384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 386585015385 active site 386585015386 phosphorylation site [posttranslational modification] 386585015387 intermolecular recognition site; other site 386585015388 dimerization interface [polypeptide binding]; other site 386585015389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 386585015390 DNA binding site [nucleotide binding] 386585015391 putative RNA methyltransferase; Provisional; Region: PRK10433 386585015392 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050