-- dump date 20140619_085905 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 386585000001 SEQ_END SEQ_END NC_002127.1 3306 3306 DR NC_002127.1; contig end 3306..3306 Escherichia coli O157:H7 str. Sakai 386585000002 SEQ_END SEQ_END NC_002128.1 92721 92721 DR NC_002128.1; contig end 92721..92721 Escherichia coli O157:H7 str. Sakai 386585000003 SEQ_END SEQ_END NC_002695.1 5498450 5498450 DR NC_002695.1; contig end 5498450..5498450 Escherichia coli O157:H7 str. Sakai NP_052604.1 CDS mobA NC_002127.1 413 736 D plasmid mobilization 413..736 Escherichia coli O157:H7 str. Sakai 1789662 NP_052605.1 CDS pOSAK1_02 NC_002127.1 971 1351 R hypothetical protein complement(971..1351) Escherichia coli O157:H7 str. Sakai 1789661 NP_052606.1 CDS pOSAK1_03 NC_002127.1 1348 2388 R hypothetical protein complement(1348..2388) Escherichia coli O157:H7 str. Sakai 1789663 NP_052607.1 CDS tagA NC_002128.1 92527 2502 D ToxR-regulated lipoprotein join(92527..92721,1..2502) Escherichia coli O157:H7 str. Sakai 1789672 NP_052608.1 CDS etpC NC_002128.1 2589 3464 D type II secretion pathway related protein; EtpC 2589..3464 Escherichia coli O157:H7 str. Sakai 1789731 NP_052609.1 CDS etpD NC_002128.1 3675 5432 D type II secretion pathway related protein; EtpD 3675..5432 Escherichia coli O157:H7 str. Sakai 1789733 NP_052610.1 CDS etpE NC_002128.1 5432 6937 D type II secretion pathway related protein; EtpE 5432..6937 Escherichia coli O157:H7 str. Sakai 1789725 NP_052611.1 CDS etpF NC_002128.1 6939 8162 D type II secretion pathway related protein; EtpF 6939..8162 Escherichia coli O157:H7 str. Sakai 1789729 NP_052612.1 CDS etpG NC_002128.1 8193 8627 D type II secretion pathway related protein; EtpG 8193..8627 Escherichia coli O157:H7 str. Sakai 1789711 NP_052613.1 CDS etpH NC_002128.1 8624 9178 D type II secretion pathway related protein; EtpH 8624..9178 Escherichia coli O157:H7 str. Sakai 1789742 NP_052614.1 CDS etpI NC_002128.1 9193 9540 D type II secretion pathway related protein; EtpI 9193..9540 Escherichia coli O157:H7 str. Sakai 1789681 NP_052615.1 CDS etpJ NC_002128.1 9537 10136 D type II secretion pathway related protein; EptJ 9537..10136 Escherichia coli O157:H7 str. Sakai 1789730 NP_052616.1 CDS etpK NC_002128.1 10133 11110 D type II secretion pathway related protein; EtpK 10133..11110 Escherichia coli O157:H7 str. Sakai 1789734 NP_052617.1 CDS etpL NC_002128.1 11473 12321 D type II secretion pathway related protein; EtpL 11473..12321 Escherichia coli O157:H7 str. Sakai 1789704 NP_052618.1 CDS etpM NC_002128.1 12308 12820 D type II secretion pathway related protein; EtpM 12308..12820 Escherichia coli O157:H7 str. Sakai 1789716 NP_052619.1 CDS etpN NC_002128.1 12995 13711 D type II secretion pathway related protein; EptN 12995..13711 Escherichia coli O157:H7 str. Sakai 1789664 NP_052620.1 CDS etpO NC_002128.1 13803 14204 D type II secretion pathway related protein; EptO 13803..14204 Escherichia coli O157:H7 str. Sakai 1789743 NP_052621.1 CDS pO157p15 NC_002128.1 14347 14688 D hypothetical 12.7 kDa protein encoded in insertion element IS911; similar to SwissProt accession number P39213; hypothetical protein 14347..14688 Escherichia coli O157:H7 str. Sakai 1789717 NP_052622.1 CDS pO157p16 NC_002128.1 14733 15554 D similar to PIR accession number S56510; hypothetical protein 14733..15554 Escherichia coli O157:H7 str. Sakai 1789706 NP_052623.1 CDS hlyC NC_002128.1 16119 16610 D hemolysin C 16119..16610 Escherichia coli O157:H7 str. Sakai 1789689 NP_052624.1 CDS hlyA NC_002128.1 16612 19608 D hemolysin A 16612..19608 Escherichia coli O157:H7 str. Sakai 1789686 NP_052625.1 CDS hlyB NC_002128.1 19658 21778 D hemolysin B 19658..21778 Escherichia coli O157:H7 str. Sakai 1789727 NP_052626.1 CDS hlyD NC_002128.1 21782 23221 D hemolysin D 21782..23221 Escherichia coli O157:H7 str. Sakai 1789705 NP_958720.1 CDS ECp021.1n NC_002128.1 23288 23482 D hypothetical protein 23288..23482 Escherichia coli O157:H7 str. Sakai 2717077 NP_052627.1 CDS papX NC_002128.1 23512 23796 D similar to SwissProt accession number P42193; PapX 23512..23796 Escherichia coli O157:H7 str. Sakai 1789696 NP_958721.1 CDS ECp023 NC_002128.1 23965 24195 D hypothetical protein 23965..24195 Escherichia coli O157:H7 str. Sakai 2717075 NP_052628.1 CDS pO157p22 NC_002128.1 24316 25056 D probable site-specific recombinase in AFA region; similar to SwissProt accession number Q47036; recombinase 24316..25056 Escherichia coli O157:H7 str. Sakai 1789708 NP_052629.1 CDS pO157p23 NC_002128.1 24745 25062 R hypothetical protein complement(24745..25062) Escherichia coli O157:H7 str. Sakai 1789668 NP_052630.2 CDS repFIB NC_002128.1 25341 26318 R replication protein RepFIB (P307 replicon); similar to PIR accession number A32310; RepFIB complement(25341..26318) Escherichia coli O157:H7 str. Sakai 1789691 NP_052631.1 CDS pO157p25 NC_002128.1 26056 26385 D hypothetical protein 26056..26385 Escherichia coli O157:H7 str. Sakai 1789679 NP_958722.1 CDS ECp025.2n NC_002128.1 26726 26926 R hypothetical protein complement(26726..26926) Escherichia coli O157:H7 str. Sakai 2717076 NP_052632.1 CDS pO157p26 NC_002128.1 26923 27543 R hypothetical protein complement(26923..27543) Escherichia coli O157:H7 str. Sakai 1789739 NP_052633.1 CDS pO157p27 NC_002128.1 27540 28223 R KfrAs complement(27540..28223) Escherichia coli O157:H7 str. Sakai 1789712 NP_052634.1 CDS letA NC_002128.1 28682 28900 D CcdA protein; protein H; LynA; similar to SwissProt accession number P05702; plasmid maintenance protein CcdA 28682..28900 Escherichia coli O157:H7 str. Sakai 1789714 NP_052635.1 CDS letB NC_002128.1 28902 29207 D cytotoxic protein; controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 28902..29207 Escherichia coli O157:H7 str. Sakai 1789728 NP_052636.1 CDS pO157p30 NC_002128.1 29208 30014 D Protein D; similar to SwissProt accession number P06615; resolvase 29208..30014 Escherichia coli O157:H7 str. Sakai 1789694 NP_052637.1 CDS pO157p31 NC_002128.1 30736 31626 R similar to SwissProt accession number P16942; transposase encoded in insertion sequence IS629; transposase complement(30736..31626) Escherichia coli O157:H7 str. Sakai 1789677 NP_052638.1 CDS pO157p83 NC_002128.1 31623 31949 R hypothetical 12 kDa protein encoded in insertion sequence IS629; similar to SwissProt accession number P16941; hypothetical protein complement(31623..31949) Escherichia coli O157:H7 str. Sakai 3399562 NP_052640.1 CDS sopA NC_002128.1 32837 34003 D Protein A; similar to SwissProt accession number P08866; plasmid-partitioning protein SopA 32837..34003 Escherichia coli O157:H7 str. Sakai 1789690 NP_052641.1 CDS sopB NC_002128.1 34003 34974 D SopB; plasmid-partitioning protein 34003..34974 Escherichia coli O157:H7 str. Sakai 1789685 NP_052642.1 CDS pO157p35 NC_002128.1 36274 37998 D similar to SwissProt accession number P19593; reverse transcriptase 36274..37998 Escherichia coli O157:H7 str. Sakai 1789698 NP_052643.1 CDS pO157p36 NC_002128.1 38075 38977 D hypothetical protein 38075..38977 Escherichia coli O157:H7 str. Sakai 1789718 NP_052644.1 CDS pO157p37 NC_002128.1 38981 39286 D hypothetical protein 38981..39286 Escherichia coli O157:H7 str. Sakai 1789693 NP_052645.1 CDS pO157p38 NC_002128.1 39363 40046 D similar to PIR accession number S18997; putative methylase 39363..40046 Escherichia coli O157:H7 str. Sakai 1789670 NP_958723.1 CDS ECp042 NC_002128.1 40047 40268 D hypothetical protein 40047..40268 Escherichia coli O157:H7 str. Sakai 2717073 NP_052646.1 CDS pO157p39 NC_002128.1 40162 40716 D hypothetical protein 40162..40716 Escherichia coli O157:H7 str. Sakai 1789700 NP_052647.1 CDS pO157p40 NC_002128.1 40762 41538 D hypothetical protein 40762..41538 Escherichia coli O157:H7 str. Sakai 1789709 NP_052648.1 CDS pO157p41 NC_002128.1 41411 41983 D hypothetical protein 41411..41983 Escherichia coli O157:H7 str. Sakai 1789736 NP_052649.1 CDS klcA NC_002128.1 42079 42381 D antirestriction protein; similar to SwissProt accession number P52603; hypothetical protein 42079..42381 Escherichia coli O157:H7 str. Sakai 1789678 NP_052650.1 CDS pO157p43 NC_002128.1 42428 42850 D hypothetical protein 42428..42850 Escherichia coli O157:H7 str. Sakai 1789683 NP_052651.1 CDS pO157p44 NC_002128.1 43157 43546 D hypothetical protein 43157..43546 Escherichia coli O157:H7 str. Sakai 1789726 NP_052652.1 CDS pO157p45 NC_002128.1 44034 44264 D hypothetical protein 44034..44264 Escherichia coli O157:H7 str. Sakai 1789665 NP_052653.1 CDS pO157p46 NC_002128.1 44316 45677 D hypothetical protein 44316..45677 Escherichia coli O157:H7 str. Sakai 1789741 NP_052654.1 CDS pO157p47 NC_002128.1 45724 46287 D hypothetical protein 45724..46287 Escherichia coli O157:H7 str. Sakai 1789684 NP_052655.1 CDS pO157p48 NC_002128.1 46373 46828 R hypothetical protein complement(46373..46828) Escherichia coli O157:H7 str. Sakai 1789721 NP_052656.1 CDS ssb NC_002128.1 47130 47582 D similar to SwissProt accession number P18310; helix-destabilizing protein; single-stranded DNA-binding protein 47130..47582 Escherichia coli O157:H7 str. Sakai 1789738 NP_958724.1 CDS ECp054 NC_002128.1 47639 47872 D hypothetical protein 47639..47872 Escherichia coli O157:H7 str. Sakai 2717072 NP_052657.1 CDS pO157p50 NC_002128.1 47938 49896 D hypothetical protein 47938..49896 Escherichia coli O157:H7 str. Sakai 1789702 NP_052658.1 CDS psiB NC_002128.1 49951 50385 D responsible for plasmid SOS inhibition; similar to PIR accession number S01898; plasmid SOS inhibition protein B 49951..50385 Escherichia coli O157:H7 str. Sakai 1789688 NP_052659.1 CDS psiA NC_002128.1 50382 51143 D PsiA; plasmid SOS inhibition protein A 50382..51143 Escherichia coli O157:H7 str. Sakai 1789722 NP_052660.1 CDS parB NC_002128.1 51375 51533 D F leading maintenance protein; similar to SwissProt accession number P16077; small toxic polypeptide 51375..51533 Escherichia coli O157:H7 str. Sakai 1789673 NP_052661.1 CDS nikB NC_002128.1 51715 53688 D similar to PIR accession number B38529; NikB 51715..53688 Escherichia coli O157:H7 str. Sakai 1789737 NP_052662.1 CDS pO157p55 NC_002128.1 53756 54187 D hypothetical protein 53756..54187 Escherichia coli O157:H7 str. Sakai 1789666 NP_052663.1 CDS pO157p56 NC_002128.1 54761 55120 R encoded in insertion sequence IS3; transposase Tra5 complement(54761..55120) Escherichia coli O157:H7 str. Sakai 1789692 NP_052664.1 CDS pO157p57 NC_002128.1 55302 55712 D encoded in insertion sequence element IS21; similar to SwissProt accession number P15025; transposase 55302..55712 Escherichia coli O157:H7 str. Sakai 1789710 NP_052665.1 CDS toxB NC_002128.1 55981 65490 D similar to SwissProt accession number P18177; toxin B 55981..65490 Escherichia coli O157:H7 str. Sakai 1789667 NP_052666.1 CDS pO157p59 NC_002128.1 65582 65854 D encoded in insertion sequence IS3; transposase Tra5 65582..65854 Escherichia coli O157:H7 str. Sakai 1789744 NP_052667.1 CDS IS629 NC_002128.1 65781 66284 R similar to SwissProt accession number P16941; hypothetical protein complement(65781..66284) Escherichia coli O157:H7 str. Sakai 1789703 NP_052669.1 CDS traX NC_002128.1 67749 68495 D similar to SwissProt accession number P22710; conjugal transfer pilus acetylation protein TraX 67749..68495 Escherichia coli O157:H7 str. Sakai 1789740 NP_052670.1 CDS pO157p63 NC_002128.1 68554 69414 D similar to SwissProt accession number Q99390; hypothetical protein 68554..69414 Escherichia coli O157:H7 str. Sakai 1789674 NP_052671.1 CDS finO NC_002128.1 69517 70077 D conjugal transfer repressor; similar to SwissProt accession number P08315; conjugal transfer fertility inhibition protein FinO 69517..70077 Escherichia coli O157:H7 str. Sakai 1789697 NP_958725.1 CDS ECp070 NC_002128.1 70210 70422 D hypothetical protein 70210..70422 Escherichia coli O157:H7 str. Sakai 2717079 NP_052672.1 CDS pO157p65 NC_002128.1 70667 71128 D similar to SwissProt accession number Q99342; hypothetical protein 70667..71128 Escherichia coli O157:H7 str. Sakai 1789676 NP_958726.1 CDS ECp072 NC_002128.1 71174 71383 D hypothetical protein 71174..71383 Escherichia coli O157:H7 str. Sakai 2717074 NP_052673.1 CDS pO157p66 NC_002128.1 71421 71759 D similar to PIR accession number S28661; hypothetical protein 71421..71759 Escherichia coli O157:H7 str. Sakai 1789675 NP_052674.1 CDS repA2 NC_002128.1 71999 72253 D similar to SwissProt accession number P03847; replication protein 71999..72253 Escherichia coli O157:H7 str. Sakai 1789682 NP_052675.1 CDS repA1 NC_002128.1 72556 73413 D RepA; replication protein 72556..73413 Escherichia coli O157:H7 str. Sakai 1789669 NP_052676.1 CDS pO157p69 NC_002128.1 74325 74609 D hypothetical protein 74325..74609 Escherichia coli O157:H7 str. Sakai 1789719 NP_052677.1 CDS pO157p70 NC_002128.1 74609 74884 D hypothetical protein 74609..74884 Escherichia coli O157:H7 str. Sakai 1789745 NP_052678.1 CDS pO157p71 NC_002128.1 74979 75185 D stability (stb) locus of IncFII plasmid NR1; similar to SwissProt accession number P11907; hypothetical protein 74979..75185 Escherichia coli O157:H7 str. Sakai 1789723 NP_052681.1 CDS pO157p74 NC_002128.1 76062 76526 R encoded in insertion sequence IS91; similar to PIR accession number S23782; transposase complement(76062..76526) Escherichia coli O157:H7 str. Sakai 1789699 NP_052684.1 CDS pO157p77 NC_002128.1 79689 80576 D encoded in insertion sequence IS629; similar to SwissProt accession number P16942; transposase 79689..80576 Escherichia coli O157:H7 str. Sakai 1789701 NP_052685.1 CDS espP NC_002128.1 80757 84659 D extracellular serine protease; EspP 80757..84659 Escherichia coli O157:H7 str. Sakai 1789732 NP_958727.1 CDS ECp088.2c NC_002128.1 85124 85396 R hypothetical protein complement(85124..85396) Escherichia coli O157:H7 str. Sakai 2717078 NP_052686.1 CDS pO157p79 NC_002128.1 87222 87659 D hypothetical protein 87222..87659 Escherichia coli O157:H7 str. Sakai 1789680 NP_052687.1 CDS pO157p80 NC_002128.1 87659 88765 D RfbU-like protein 87659..88765 Escherichia coli O157:H7 str. Sakai 1789671 NP_052688.1 CDS pO157p81 NC_002128.1 88855 90576 D similar to SwissProt accession number P32678; hypothetical protein 88855..90576 Escherichia coli O157:H7 str. Sakai 1789713 NP_052689.1 CDS pO157p82 NC_002128.1 90650 91648 D Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 90650..91648 Escherichia coli O157:H7 str. Sakai 1789687 NP_308028.1 CDS thrL NC_002695.1 190 273 D involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 190..273 Escherichia coli O157:H7 str. Sakai 913387 NP_308029.1 CDS thrA NC_002695.1 354 2816 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 354..2816 Escherichia coli O157:H7 str. Sakai 913388 NP_308030.1 CDS ECs0003 NC_002695.1 2818 3750 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2818..3750 Escherichia coli O157:H7 str. Sakai 913390 NP_308031.1 CDS ECs0004 NC_002695.1 3751 5037 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3751..5037 Escherichia coli O157:H7 str. Sakai 913393 NP_308032.1 CDS ECs0005 NC_002695.1 5251 5547 D similar to B0005_ECOLI gi|1786186 (conserved in Escherichia coli K-12); hypothetical protein 5251..5547 Escherichia coli O157:H7 str. Sakai 913394 NP_308033.1 CDS ECs0006 NC_002695.1 5700 6476 R similar to YAAA_ECOLI gi|1786187 (conserved in Escherichia coli K-12); hypothetical protein complement(5700..6476) Escherichia coli O157:H7 str. Sakai 913395 NP_308034.1 CDS ECs0007 NC_002695.1 6546 7976 R similar to YAAJ_ECOLI gi|1786188 (conserved in Escherichia coli K-12); inner membrane transport protein complement(6546..7976) Escherichia coli O157:H7 str. Sakai 913398 NP_308035.1 CDS ECs0008 NC_002695.1 8255 9208 D Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 8255..9208 Escherichia coli O157:H7 str. Sakai 913400 NP_308036.1 CDS mogA NC_002695.1 9323 9910 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9323..9910 Escherichia coli O157:H7 str. Sakai 913401 NP_308037.1 CDS ECs0010 NC_002695.1 9945 10511 R similar to YAAH_ECOLI gi|1786191 (conserved in Escherichia coli K-12); hypothetical protein complement(9945..10511) Escherichia coli O157:H7 str. Sakai 913402 NP_308038.1 CDS ECs0012 NC_002695.1 10660 11373 R similar to B0011_ECOLI gi|1786193 (conserved in Escherichia coli K-12); hypothetical protein complement(10660..11373) Escherichia coli O157:H7 str. Sakai 913403 NP_308040.1 CDS ECs0013 NC_002695.1 11399 11803 R similar to YAAI_ECOLI gi|1786195 (conserved in Escherichia coli K-12); hypothetical protein complement(11399..11803) Escherichia coli O157:H7 str. Sakai 913405 NP_308041.1 CDS dnaK NC_002695.1 12180 14096 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12180..14096 Escherichia coli O157:H7 str. Sakai 913406 NP_308042.1 CDS ECs0015 NC_002695.1 14185 15315 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 14185..15315 Escherichia coli O157:H7 str. Sakai 913407 NP_308043.1 CDS ECs0016 NC_002695.1 15419 15628 R similar to GEF_ECOLI gi|1786200 (conserved in Escherichia coli K-12); Gef protein complement(15419..15628) Escherichia coli O157:H7 str. Sakai 913408 NP_308044.1 CDS nhaA NC_002695.1 16157 17323 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 16157..17323 Escherichia coli O157:H7 str. Sakai 913409 NP_308045.1 CDS nhaR NC_002695.1 17383 18288 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 17383..18288 Escherichia coli O157:H7 str. Sakai 913410 NP_308046.1 CDS ECs0019 NC_002695.1 18326 18853 R hypothetical protein complement(18326..18853) Escherichia coli O157:H7 str. Sakai 913413 NP_308048.1 CDS ECs0021 NC_002695.1 18959 19285 R hypothetical protein complement(18959..19285) Escherichia coli O157:H7 str. Sakai 913415 NP_308049.1 CDS ECs0022 NC_002695.1 19298 21748 R similar to outer membrane usher protein precursors e.g. YehB [Escherichia coli K-12] gi|465572|sp|P33341|YEHB_ECOLI; outer membrane usher protein complement(19298..21748) Escherichia coli O157:H7 str. Sakai 913416 NP_308050.1 CDS ECs0023 NC_002695.1 21761 22444 R similar to fimbrial chaperones e.g. YehC [Escherichia coli] gi|465573|sp|P33342|YEHC_ECOLI; fimbrial chaperone complement(21761..22444) Escherichia coli O157:H7 str. Sakai 913417 NP_308051.1 CDS ECs0024 NC_002695.1 22494 23027 R similar to YehD [Escherichia coli] gi|465574|sp|P33343|YEHD_ECOLI, long polar fimbrial major protein [Salmonella typhimurium] gi|1170815|sp|P43660|LPFA_SALT; fimbrial protein complement(22494..23027) Escherichia coli O157:H7 str. Sakai 913418 NP_308052.1 CDS ECs0025 NC_002695.1 23329 24750 R hypothetical protein complement(23329..24750) Escherichia coli O157:H7 str. Sakai 913419 NP_308053.1 CDS rpsT NC_002695.1 25220 25483 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(25220..25483) Escherichia coli O157:H7 str. Sakai 913420 NP_308054.1 CDS ECs0027 NC_002695.1 25586 25810 D similar to B0024_ECOLI gi|1786207 (conserved in Escherichia coli K-12); hypothetical protein 25586..25810 Escherichia coli O157:H7 str. Sakai 913422 NP_308055.1 CDS ECs0028 NC_002695.1 25818 26759 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 25818..26759 Escherichia coli O157:H7 str. Sakai 913423 NP_308056.1 CDS ileS NC_002695.1 26802 29618 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 26802..29618 Escherichia coli O157:H7 str. Sakai 913425 NP_308057.1 CDS lspA NC_002695.1 29618 30112 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 29618..30112 Escherichia coli O157:H7 str. Sakai 913426 NP_308058.1 CDS ECs0031 NC_002695.1 30200 30649 D similar to SLPA_ECOLI gi|1786211 (conserved in Escherichia coli K-12); FKBP-type peptidyl-prolyl cis-trans isomerase 30200..30649 Escherichia coli O157:H7 str. Sakai 913427 NP_308059.1 CDS ispH NC_002695.1 30651 31601 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 30651..31601 Escherichia coli O157:H7 str. Sakai 913428 NP_308060.1 CDS ECs0033 NC_002695.1 31667 32581 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 31667..32581 Escherichia coli O157:H7 str. Sakai 913429 NP_308061.1 CDS ECs0034 NC_002695.1 32748 33569 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 32748..33569 Escherichia coli O157:H7 str. Sakai 913430 NP_308062.1 CDS ECs0035 NC_002695.1 34025 35173 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 34025..35173 Escherichia coli O157:H7 str. Sakai 913431 NP_308063.1 CDS carB NC_002695.1 35191 38412 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 35191..38412 Escherichia coli O157:H7 str. Sakai 913432 NP_944498.1 CDS ECs5362 NC_002695.1 38420 38638 R hypothetical protein complement(38420..38638) Escherichia coli O157:H7 str. Sakai 2693794 NP_308064.2 CDS ECs0037 NC_002695.1 38673 39068 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; CaiF family transcriptional regulator 38673..39068 Escherichia coli O157:H7 str. Sakai 913433 NP_308065.1 CDS ECs0038 NC_002695.1 39187 39798 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(39187..39798) Escherichia coli O157:H7 str. Sakai 913434 NP_308066.2 CDS ECs0039 NC_002695.1 39783 40568 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(39783..40568) Escherichia coli O157:H7 str. Sakai 913435 NP_308067.1 CDS caiC NC_002695.1 40677 42245 R similar to CAIC_ECOLI gi|1786221 (conserved in Escherichia coli K-12); crotonobetaine/carnitine-CoA ligase complement(40677..42245) Escherichia coli O157:H7 str. Sakai 913437 NP_308068.1 CDS ECs0041 NC_002695.1 42304 43521 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(42304..43521) Escherichia coli O157:H7 str. Sakai 913438 NP_308069.1 CDS ECs0042 NC_002695.1 43650 44792 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(43650..44792) Escherichia coli O157:H7 str. Sakai 913439 NP_308070.1 CDS ECs0043 NC_002695.1 44823 46337 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(44823..46337) Escherichia coli O157:H7 str. Sakai 913440 NP_308071.2 CDS ECs0044 NC_002695.1 46816 47586 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 46816..47586 Escherichia coli O157:H7 str. Sakai 913441 NP_308072.1 CDS fixB NC_002695.1 47601 48542 D involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 47601..48542 Escherichia coli O157:H7 str. Sakai 913442 NP_308073.1 CDS ECs0046 NC_002695.1 48593 49879 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 48593..49879 Escherichia coli O157:H7 str. Sakai 913445 NP_308074.1 CDS ECs0047 NC_002695.1 49876 50163 D similar to FIXX_ECOLI gi|1786228 (conserved in Escherichia coli K-12); ferredoxin 49876..50163 Escherichia coli O157:H7 str. Sakai 913446 NP_308075.1 CDS ECs0048 NC_002695.1 50221 51552 D similar to YAAU_ECOLI gi|1786229 (conserved in Escherichia coli K-12); transporter 50221..51552 Escherichia coli O157:H7 str. Sakai 913447 NP_308076.1 CDS ECs0049 NC_002695.1 51660 52190 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 51660..52190 Escherichia coli O157:H7 str. Sakai 913448 NP_308077.1 CDS ECs0050 NC_002695.1 52183 54045 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 52183..54045 Escherichia coli O157:H7 str. Sakai 913449 NP_308078.1 CDS folA NC_002695.1 54237 54716 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 54237..54716 Escherichia coli O157:H7 str. Sakai 913450 NP_308079.1 CDS ECs0052 NC_002695.1 54802 55035 D similar to CcdA protein (LetA protein) of F plasmid [Escherichia coli] gi|9507755|ref|NP_061421.1; CcdA-like protein 54802..55035 Escherichia coli O157:H7 str. Sakai 913451 NP_308080.1 CDS ECs0053 NC_002695.1 55038 55352 D similar to CcdB protein (LetB protein) of plasmid F [Escherichia coli] gi|9507756|ref|NP_061422.1; CcdB-like protein 55038..55352 Escherichia coli O157:H7 str. Sakai 913452 NP_308081.1 CDS apaH NC_002695.1 55349 56197 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(55349..56197) Escherichia coli O157:H7 str. Sakai 913453 NP_308082.1 CDS apaG NC_002695.1 56204 56581 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(56204..56581) Escherichia coli O157:H7 str. Sakai 913454 NP_308083.1 CDS ksgA NC_002695.1 56584 57405 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(56584..57405) Escherichia coli O157:H7 str. Sakai 913455 NP_308084.1 CDS pdxA NC_002695.1 57402 58391 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(57402..58391) Escherichia coli O157:H7 str. Sakai 913457 NP_308085.1 CDS ECs0058 NC_002695.1 58391 59677 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(58391..59677) Escherichia coli O157:H7 str. Sakai 913458 NP_308086.1 CDS ECs0059 NC_002695.1 59730 62084 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(59730..62084) Escherichia coli O157:H7 str. Sakai 913459 NP_308087.1 CDS djlA NC_002695.1 62339 63154 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 62339..63154 Escherichia coli O157:H7 str. Sakai 913460 NP_308088.1 CDS ECs0061 NC_002695.1 63449 64201 D similar to YABP_ECOLI gi|1786242 (conserved in Escherichia coli K-12); hypothetical protein 63449..64201 Escherichia coli O157:H7 str. Sakai 913461 NP_308089.1 CDS ECs0062 NC_002695.1 64619 65278 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(64619..65278) Escherichia coli O157:H7 str. Sakai 913462 NP_308090.1 CDS ECs0063 NC_002695.1 65290 68196 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(65290..68196) Escherichia coli O157:H7 str. Sakai 913463 NP_308091.1 CDS ECs0064 NC_002695.1 68360 70711 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(68360..70711) Escherichia coli O157:H7 str. Sakai 913464 NP_308092.1 CDS araD NC_002695.1 70786 71481 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(70786..71481) Escherichia coli O157:H7 str. Sakai 913465 NP_308093.1 CDS ECs0066 NC_002695.1 71681 73183 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(71681..73183) Escherichia coli O157:H7 str. Sakai 913468 NP_308094.1 CDS ECs0067 NC_002695.1 73194 74894 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(73194..74894) Escherichia coli O157:H7 str. Sakai 913471 NP_308095.1 CDS ECs0068 NC_002695.1 75233 76111 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; AraC family transcriptional regulator 75233..76111 Escherichia coli O157:H7 str. Sakai 913473 NP_308096.1 CDS ECs0069 NC_002695.1 76197 76961 D similar to YABI_ECOLI gi|1786252 (conserved in Escherichia coli K-12); hypothetical protein 76197..76961 Escherichia coli O157:H7 str. Sakai 913477 NP_308097.1 CDS thiQ NC_002695.1 77048 77746 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding protein complement(77048..77746) Escherichia coli O157:H7 str. Sakai 913478 NP_308098.1 CDS thiP NC_002695.1 77730 79340 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(77730..79340) Escherichia coli O157:H7 str. Sakai 913479 NP_308099.1 CDS tbpA NC_002695.1 79316 80299 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(79316..80299) Escherichia coli O157:H7 str. Sakai 913490 NP_308100.1 CDS ECs0073 NC_002695.1 80671 81240 D similar to YABP_ECOLI gi|2506583|sp|P39220; hypothetical protein 80671..81240 Escherichia coli O157:H7 str. Sakai 913497 NP_308101.1 CDS ECs0074 NC_002695.1 81469 83127 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(81469..83127) Escherichia coli O157:H7 str. Sakai 913502 NP_308102.1 CDS leuD NC_002695.1 83455 84060 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(83455..84060) Escherichia coli O157:H7 str. Sakai 913503 NP_308103.1 CDS ECs0076 NC_002695.1 84071 85471 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(84071..85471) Escherichia coli O157:H7 str. Sakai 913504 NP_308104.2 CDS ECs0077 NC_002695.1 85474 86565 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(85474..86565) Escherichia coli O157:H7 str. Sakai 913510 NP_308105.1 CDS ECs0078 NC_002695.1 86565 88136 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(86565..88136) Escherichia coli O157:H7 str. Sakai 913513 NP_308106.1 CDS ECs0079 NC_002695.1 88229 88315 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(88229..88315) Escherichia coli O157:H7 str. Sakai 913517 NP_308107.2 CDS leuO NC_002695.1 88955 89917 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 88955..89917 Escherichia coli O157:H7 str. Sakai 913520 NP_308108.2 CDS ECs0081 NC_002695.1 90235 91959 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 90235..91959 Escherichia coli O157:H7 str. Sakai 913521 NP_308109.1 CDS ilvH NC_002695.1 91962 92453 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 91962..92453 Escherichia coli O157:H7 str. Sakai 913523 NP_308111.1 CDS ECs0084 NC_002695.1 92633 93637 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 92633..93637 Escherichia coli O157:H7 str. Sakai 913527 NP_308112.1 CDS ECs0085 NC_002695.1 94239 94697 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 94239..94697 Escherichia coli O157:H7 str. Sakai 913528 NP_308113.1 CDS mraW NC_002695.1 94699 95640 D similar to YABC_ECOLI gi|1786270 (conserved in Escherichia coli K-12); S-adenosyl-methyltransferase MraW 94699..95640 Escherichia coli O157:H7 str. Sakai 913531 NP_308114.1 CDS ftsL NC_002695.1 95637 96002 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 95637..96002 Escherichia coli O157:H7 str. Sakai 913534 NP_308115.1 CDS ftsI NC_002695.1 96018 97784 D septum formation protein; similar to FTSI_ECOLI gi|1786272 (conserved in Escherichia coli K-12); hypothetical protein 96018..97784 Escherichia coli O157:H7 str. Sakai 913535 NP_308116.1 CDS murE NC_002695.1 97771 99258 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 97771..99258 Escherichia coli O157:H7 str. Sakai 913536 NP_308117.1 CDS murF NC_002695.1 99255 100613 D similar to MURF_ECOLI gi|1786274 (conserved in Escherichia coli K-12); UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 99255..100613 Escherichia coli O157:H7 str. Sakai 913537 NP_308118.1 CDS mraY NC_002695.1 100607 101689 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 100607..101689 Escherichia coli O157:H7 str. Sakai 913542 NP_308119.1 CDS murD NC_002695.1 101692 103008 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 101692..103008 Escherichia coli O157:H7 str. Sakai 913546 NP_308120.1 CDS ECs0093 NC_002695.1 103008 104252 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 103008..104252 Escherichia coli O157:H7 str. Sakai 913549 NP_308121.1 CDS murG NC_002695.1 104249 105316 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 104249..105316 Escherichia coli O157:H7 str. Sakai 913552 NP_308122.1 CDS murC NC_002695.1 105370 106845 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 105370..106845 Escherichia coli O157:H7 str. Sakai 913555 NP_308123.1 CDS ddl NC_002695.1 106838 107758 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 106838..107758 Escherichia coli O157:H7 str. Sakai 913558 NP_308124.1 CDS ECs0097 NC_002695.1 107760 108590 D involved in septum formation; cell division protein FtsQ 107760..108590 Escherichia coli O157:H7 str. Sakai 913560 NP_308125.1 CDS ftsA NC_002695.1 108587 109849 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 108587..109849 Escherichia coli O157:H7 str. Sakai 913567 NP_308126.1 CDS ECs0099 NC_002695.1 109910 111061 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 109910..111061 Escherichia coli O157:H7 str. Sakai 913575 NP_308127.1 CDS lpxC NC_002695.1 111162 112079 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 111162..112079 Escherichia coli O157:H7 str. Sakai 913579 NP_308128.2 CDS ECs0101 NC_002695.1 112310 112822 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 112310..112822 Escherichia coli O157:H7 str. Sakai 913588 NP_308129.1 CDS secA NC_002695.1 112884 115589 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 112884..115589 Escherichia coli O157:H7 str. Sakai 913599 NP_308130.1 CDS ECs0103 NC_002695.1 115649 116047 D similar to MUTT_ECOLI gi|1786288 (conserved in Escherichia coli K-12); nucleoside triphosphate pyrophosphohydrolase 115649..116047 Escherichia coli O157:H7 str. Sakai 913600 NP_308132.1 CDS ECs0105 NC_002695.1 116138 116335 R similar to YACG_ECOLI gi|1786290 (conserved in Escherichia coli K-12); zinc-binding protein complement(116138..116335) Escherichia coli O157:H7 str. Sakai 913611 NP_308133.1 CDS ECs0106 NC_002695.1 116345 117088 R similar to YACF_ECOLI gi|1786291 (conserved in Escherichia coli K-12); hypothetical protein complement(116345..117088) Escherichia coli O157:H7 str. Sakai 913614 NP_308134.1 CDS coaE NC_002695.1 117088 117708 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(117088..117708) Escherichia coli O157:H7 str. Sakai 913615 NP_308135.1 CDS ECs0108 NC_002695.1 117933 118976 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 117933..118976 Escherichia coli O157:H7 str. Sakai 913617 NP_308137.1 CDS ECs0110 NC_002695.1 119011 120213 R integral membrane protein; similar to HOFC_ECOLI gi|1786295 (conserved in Escherichia coli K-12); type IV pilin biogenesis protein complement(119011..120213) Escherichia coli O157:H7 str. Sakai 913621 NP_308138.1 CDS ECs0111 NC_002695.1 120203 121588 R integral membrane protein; similar to HOFB_ECOLI gi|1786296 (conserved in Escherichia coli K-12); hypothetical protein complement(120203..121588) Escherichia coli O157:H7 str. Sakai 913626 NP_308139.1 CDS ECs0112 NC_002695.1 121598 122038 R similar to PPDD_ECOLI gi|1786297 (conserved in Escherichia coli K-12); major pilin subunit complement(121598..122038) Escherichia coli O157:H7 str. Sakai 913629 NP_944499.1 CDS ECs5363 NC_002695.1 122063 122284 D hypothetical protein 122063..122284 Escherichia coli O157:H7 str. Sakai 2693812 NP_308140.1 CDS ECs0113 NC_002695.1 122241 123134 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(122241..123134) Escherichia coli O157:H7 str. Sakai 913630 NP_308141.1 CDS ECs0114 NC_002695.1 123222 123773 D similar to AMPD_ECOLI gi|1786300 (conserved in Escherichia coli K-12); N-acetyl-anhydromuranmyl-L-alanine amidase 123222..123773 Escherichia coli O157:H7 str. Sakai 913635 NP_308142.1 CDS ECs0115 NC_002695.1 123770 124624 D involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 123770..124624 Escherichia coli O157:H7 str. Sakai 913637 NP_308143.1 CDS ECs0116 NC_002695.1 124667 126040 R similar to AROP_ECOLI gi|1786302 (conserved in Escherichia coli K-12); aromatic amino acid transporter complement(124667..126040) Escherichia coli O157:H7 str. Sakai 913640 NP_308144.1 CDS pdhR NC_002695.1 126581 127345 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 126581..127345 Escherichia coli O157:H7 str. Sakai 913643 NP_308145.1 CDS aceE NC_002695.1 127506 130169 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 127506..130169 Escherichia coli O157:H7 str. Sakai 913657 NP_308146.1 CDS aceF NC_002695.1 130184 132076 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 130184..132076 Escherichia coli O157:H7 str. Sakai 913659 NP_308147.1 CDS lpdA NC_002695.1 132284 133708 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 132284..133708 Escherichia coli O157:H7 str. Sakai 913660 NP_308148.1 CDS ECs0121 NC_002695.1 133779 135632 R similar to YACH_ECOLI gi|1786308 (conserved in Escherichia coli K-12); hypothetical protein complement(133779..135632) Escherichia coli O157:H7 str. Sakai 913666 NP_308149.1 CDS ECs0122 NC_002695.1 135987 138584 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 135987..138584 Escherichia coli O157:H7 str. Sakai 913670 NP_308150.2 CDS ECs0123 NC_002695.1 138760 139122 D similar to YACL_ECOLI gi|1786310 (conserved in Escherichia coli K-12); hypothetical protein 138760..139122 Escherichia coli O157:H7 str. Sakai 913686 NP_308151.1 CDS ECs0124 NC_002695.1 139160 139954 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(139160..139954) Escherichia coli O157:H7 str. Sakai 913693 NP_308152.1 CDS ECs0125 NC_002695.1 139970 140836 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(139970..140836) Escherichia coli O157:H7 str. Sakai 913703 NP_308153.2 CDS ECs0126 NC_002695.1 140942 141289 R similar to YACC_ECOLI gi|1786313 (conserved in Escherichia coli K-12); hypothetical protein complement(140942..141289) Escherichia coli O157:H7 str. Sakai 913704 NP_308154.1 CDS ECs0127 NC_002695.1 141455 143005 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 141455..143005 Escherichia coli O157:H7 str. Sakai 913706 NP_308155.1 CDS ECs0128 NC_002695.1 143207 145597 R similar to GCD_ECOLI gi|1786316 (conserved in Escherichia coli K-12); glucose dehydrogenase complement(143207..145597) Escherichia coli O157:H7 str. Sakai 913709 NP_308156.2 CDS ECs0129 NC_002695.1 145803 146339 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 145803..146339 Escherichia coli O157:H7 str. Sakai 913711 NP_308157.1 CDS ECs0130 NC_002695.1 146380 147042 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(146380..147042) Escherichia coli O157:H7 str. Sakai 913712 NP_308158.1 CDS ECs0131 NC_002695.1 147151 148077 D similar to YADG_ECOLI gi|1786319 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 147151..148077 Escherichia coli O157:H7 str. Sakai 913713 NP_308159.1 CDS ECs0132 NC_002695.1 148074 148844 D similar to YADH_ECOLI gi|1786320 (conserved in Escherichia coli K-12); hypothetical protein 148074..148844 Escherichia coli O157:H7 str. Sakai 913717 NP_308160.1 CDS ECs0133 NC_002695.1 148949 149389 D similar to YADI_ECOLI gi|1786321 (conserved in Escherichia coli K-12); PTS enzyme II B component 148949..149389 Escherichia coli O157:H7 str. Sakai 913720 NP_308161.1 CDS ECs0134 NC_002695.1 149453 150682 D similar to YADE_ECOLI gi|1786322 (conserved in Escherichia coli K-12); hypothetical protein 149453..150682 Escherichia coli O157:H7 str. Sakai 913723 NP_308162.1 CDS ECs0135 NC_002695.1 150686 151066 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(150686..151066) Escherichia coli O157:H7 str. Sakai 913727 NP_308163.1 CDS ECs0136 NC_002695.1 151340 152236 D similar to YADD_ECOLI gi|1786324 (conserved in Escherichia coli K-12); hypothetical protein 151340..152236 Escherichia coli O157:H7 str. Sakai 913728 NP_308164.1 CDS panC NC_002695.1 152535 153386 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(152535..153386) Escherichia coli O157:H7 str. Sakai 913734 NP_308165.1 CDS panB NC_002695.1 153398 154192 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(153398..154192) Escherichia coli O157:H7 str. Sakai 913736 NP_308166.1 CDS ECs0139 NC_002695.1 154327 155436 R probable fimbrial protein, similar to probable fimbrial proteins e.g. [Escherichia coli] gi|538781|pir||B47152, long polar fimbrial minor protein LpfE [Salmonella typhimurium] gi|1170819|sp|P43664|LPFE_SALTY; fimbrial protein complement(154327..155436) Escherichia coli O157:H7 str. Sakai 913739 NP_308167.1 CDS ECs0140 NC_002695.1 155448 156038 R probable fimbrial protein, similar to fimbrial protein YadK [Escherichia coli] gi|549488|sp|P37016|YADK_ECOLI; fimbrial protein complement(155448..156038) Escherichia coli O157:H7 str. Sakai 913740 NP_308168.1 CDS ECs0141 NC_002695.1 156059 156664 R probable fimbrial protein, similar to fimbrial protein YadL [Escherichia coli] gi|549489|sp|P37017|YADL_ECOLI; fimbrial protein complement(156059..156664) Escherichia coli O157:H7 str. Sakai 913742 NP_308169.1 CDS ECs0142 NC_002695.1 156679 157239 R probable fimbrial protein, similar to fimbrial-like protein YadM [Escherichia coli] gi|549490|sp|P37018|YADM_ECOLI; fimbrial protein complement(156679..157239) Escherichia coli O157:H7 str. Sakai 913744 NP_308170.1 CDS ECs0143 NC_002695.1 157241 159841 R similar to the fimbrial usher protein PapC; outer membrane usher protein complement(157241..159841) Escherichia coli O157:H7 str. Sakai 913748 NP_308171.1 CDS ECs0144 NC_002695.1 159883 160608 R similar to ECPD_ECOLI gi|1786333; chaperone protein EcpD complement(159883..160608) Escherichia coli O157:H7 str. Sakai 913756 NP_308172.1 CDS ECs0145 NC_002695.1 160695 161291 R similar to YADN_ECOLI gi|1786334; fimbrial-like protein complement(160695..161291) Escherichia coli O157:H7 str. Sakai 913761 NP_308173.1 CDS ECs0146 NC_002695.1 161572 162054 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(161572..162054) Escherichia coli O157:H7 str. Sakai 913762 NP_308174.2 CDS pcnB NC_002695.1 162051 163469 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase complement(162051..163469) Escherichia coli O157:H7 str. Sakai 913763 NP_308175.2 CDS ECs0148 NC_002695.1 163508 164404 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(163508..164404) Escherichia coli O157:H7 str. Sakai 913766 NP_308176.1 CDS dksA NC_002695.1 164471 164926 R similar to DKSA_ECOLI gi|1786338 (conserved in Escherichia coli K-12); RNA polymerase-binding transcription factor complement(164471..164926) Escherichia coli O157:H7 str. Sakai 913772 NP_308177.1 CDS ECs0150 NC_002695.1 165104 165808 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(165104..165808) Escherichia coli O157:H7 str. Sakai 913774 NP_308178.2 CDS ECs0151 NC_002695.1 165823 166353 R similar to YADP_ECOLI gi|1786341 (conserved in Escherichia coli K-12); 2'-5' RNA ligase complement(165823..166353) Escherichia coli O157:H7 str. Sakai 913775 NP_308179.1 CDS ECs0152 NC_002695.1 166382 168856 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 166382..168856 Escherichia coli O157:H7 str. Sakai 913779 NP_944500.1 CDS ECs5364 NC_002695.1 168859 169065 D hypothetical protein 168859..169065 Escherichia coli O157:H7 str. Sakai 2693813 NP_308180.1 CDS mrcB NC_002695.1 169052 171586 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 169052..171586 Escherichia coli O157:H7 str. Sakai 913781 NP_308181.1 CDS ECs0154 NC_002695.1 171806 174049 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 171806..174049 Escherichia coli O157:H7 str. Sakai 913783 NP_308182.1 CDS ECs0155 NC_002695.1 174100 174897 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding protein 174100..174897 Escherichia coli O157:H7 str. Sakai 913784 NP_308183.1 CDS ECs0156 NC_002695.1 174897 175787 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 174897..175787 Escherichia coli O157:H7 str. Sakai 913786 NP_308184.1 CDS ECs0157 NC_002695.1 175784 177766 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease 175784..177766 Escherichia coli O157:H7 str. Sakai 913787 NP_308185.1 CDS ECs0158 NC_002695.1 177801 179081 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(177801..179081) Escherichia coli O157:H7 str. Sakai 913788 NP_308186.1 CDS ECs0159 NC_002695.1 179306 180727 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 179306..180727 Escherichia coli O157:H7 str. Sakai 913789 NP_308187.1 CDS ECs0160 NC_002695.1 180809 181153 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 180809..181153 Escherichia coli O157:H7 str. Sakai 913801 NP_308188.1 CDS ECs0161 NC_002695.1 181200 181823 R similar to YADS_ECOLI gi|1786352 (conserved in Escherichia coli K-12); hypothetical protein complement(181200..181823) Escherichia coli O157:H7 str. Sakai 913809 NP_308189.1 CDS ECs0162 NC_002695.1 181861 182661 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(181861..182661) Escherichia coli O157:H7 str. Sakai 913812 NP_308190.1 CDS ECs0163 NC_002695.1 182654 183352 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(182654..183352) Escherichia coli O157:H7 str. Sakai 913817 NP_308191.1 CDS dgt NC_002695.1 183436 184953 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 183436..184953 Escherichia coli O157:H7 str. Sakai 913819 NP_308192.1 CDS ECs0165 NC_002695.1 185083 186507 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 185083..186507 Escherichia coli O157:H7 str. Sakai 913821 NP_308193.1 CDS ECs0166 NC_002695.1 186662 187819 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 186662..187819 Escherichia coli O157:H7 str. Sakai 913826 NP_308194.1 CDS ECs0167 NC_002695.1 187908 188294 R similar to YAEH_ECOLI gi|1786359 (conserved in Escherichia coli K-12); hypothetical protein complement(187908..188294) Escherichia coli O157:H7 str. Sakai 913827 NP_308195.1 CDS dapD NC_002695.1 188609 189433 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(188609..189433) Escherichia coli O157:H7 str. Sakai 913832 NP_308196.1 CDS ECs0169 NC_002695.1 189464 192136 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(189464..192136) Escherichia coli O157:H7 str. Sakai 913839 NP_308197.1 CDS ECs0170 NC_002695.1 192198 192992 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(192198..192992) Escherichia coli O157:H7 str. Sakai 913847 NP_308198.1 CDS rpsB NC_002695.1 193360 194085 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 193360..194085 Escherichia coli O157:H7 str. Sakai 913849 NP_308199.1 CDS tsf NC_002695.1 194343 195194 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 194343..195194 Escherichia coli O157:H7 str. Sakai 913854 NP_308200.1 CDS pyrH NC_002695.1 195341 196066 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 195341..196066 Escherichia coli O157:H7 str. Sakai 913857 NP_308201.1 CDS frr NC_002695.1 196216 196773 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 196216..196773 Escherichia coli O157:H7 str. Sakai 913872 NP_308202.1 CDS ECs0175 NC_002695.1 196865 198061 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 196865..198061 Escherichia coli O157:H7 str. Sakai 913875 NP_308203.1 CDS ECs0176 NC_002695.1 198247 199008 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 198247..199008 Escherichia coli O157:H7 str. Sakai 913882 NP_308204.2 CDS cdsA NC_002695.1 199021 199878 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 199021..199878 Escherichia coli O157:H7 str. Sakai 913883 NP_308205.1 CDS ECs0178 NC_002695.1 199890 201242 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 199890..201242 Escherichia coli O157:H7 str. Sakai 913885 NP_308206.1 CDS ECs0179 NC_002695.1 201272 203704 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 201272..203704 Escherichia coli O157:H7 str. Sakai 913887 NP_308207.1 CDS ECs0180 NC_002695.1 203825 204310 D histone-like protein; similar to HLPA_ECOLI gi|1786375 (conserved in Escherichia coli K-12); periplasmic chaperone 203825..204310 Escherichia coli O157:H7 str. Sakai 913889 NP_308208.1 CDS lpxD NC_002695.1 204314 205339 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 204314..205339 Escherichia coli O157:H7 str. Sakai 913891 NP_308209.1 CDS fabZ NC_002695.1 205444 205899 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 205444..205899 Escherichia coli O157:H7 str. Sakai 913892 NP_308210.1 CDS ECs0183 NC_002695.1 205903 206691 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 205903..206691 Escherichia coli O157:H7 str. Sakai 913893 NP_308211.1 CDS lpxB NC_002695.1 206691 207839 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 206691..207839 Escherichia coli O157:H7 str. Sakai 913894 NP_308212.1 CDS rnhB NC_002695.1 207836 208432 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 207836..208432 Escherichia coli O157:H7 str. Sakai 913902 NP_308213.1 CDS dnaE NC_002695.1 208469 211951 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 208469..211951 Escherichia coli O157:H7 str. Sakai 913906 NP_308214.1 CDS ECs0187 NC_002695.1 211964 212923 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 211964..212923 Escherichia coli O157:H7 str. Sakai 913907 NP_308215.1 CDS ECs0188 NC_002695.1 213022 215163 D similar to LDCC_ECOLI gi|1786384 (conserved in Escherichia coli K-12); lysine decarboxylase 2 213022..215163 Escherichia coli O157:H7 str. Sakai 913910 NP_308216.2 CDS ECs0189 NC_002695.1 215220 215609 D similar to YAER_ECOLI gi|1786385 (conserved in Escherichia coli K-12); hypothetical protein 215220..215609 Escherichia coli O157:H7 str. Sakai 913914 NP_308217.1 CDS tilS NC_002695.1 215674 216969 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 215674..216969 Escherichia coli O157:H7 str. Sakai 913916 NP_308218.1 CDS ECs0191 NC_002695.1 217022 217282 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(217022..217282) Escherichia coli O157:H7 str. Sakai 913917 NP_944501.1 CDS ECs5365 NC_002695.1 217269 217487 R hypothetical protein complement(217269..217487) Escherichia coli O157:H7 str. Sakai 2693788 NP_308219.1 CDS ECs0192 NC_002695.1 217635 218093 D similar to YAEQ_ECOLI gi|1786388 (conserved in Escherichia coli K-12); hypothetical protein 217635..218093 Escherichia coli O157:H7 str. Sakai 913918 NP_308220.1 CDS ECs0193 NC_002695.1 218177 218587 D similar to YAEJ_ECOLI gi|1786389 (conserved in Escherichia coli K-12); peptidyl-tRNA hydrolase domain-containing protein 218177..218587 Escherichia coli O157:H7 str. Sakai 913932 NP_308221.1 CDS ECs0194 NC_002695.1 218601 219311 D similar to CUTF_ECOLI gi|1786390 (conserved in Escherichia coli K-12); lipoprotein involved with copper homeostasis and adhesion 218601..219311 Escherichia coli O157:H7 str. Sakai 913936 NP_308222.1 CDS ECs0195 NC_002695.1 219511 220335 R similar to YAEF_ECOLI gi|1786391 (conserved in Escherichia coli K-12); hypothetical protein complement(219511..220335) Escherichia coli O157:H7 str. Sakai 913937 NP_308223.1 CDS ECs0196 NC_002695.1 220388 222106 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(220388..222106) Escherichia coli O157:H7 str. Sakai 913939 NP_308224.1 CDS ECs0197 NC_002695.1 222217 222924 R similar to YAEB_ECOLI gi|1786393 (conserved in Escherichia coli K-12); hypothetical protein complement(222217..222924) Escherichia coli O157:H7 str. Sakai 913945 NP_308225.1 CDS rcsF NC_002695.1 222921 223325 R similar to RCSF_ECOLI gi|1786394 (conserved in Escherichia coli K-12); outer membrane lipoprotein complement(222921..223325) Escherichia coli O157:H7 str. Sakai 913950 NP_308226.1 CDS metQ NC_002695.1 223443 224258 R similar to YAEC_ECOLI gi|1786396 (conserved in Escherichia coli K-12); DL-methionine transporter substrate-binding subunit complement(223443..224258) Escherichia coli O157:H7 str. Sakai 913959 NP_308227.1 CDS ECs0200 NC_002695.1 224298 224951 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease complement(224298..224951) Escherichia coli O157:H7 str. Sakai 913960 NP_308228.1 CDS metN NC_002695.1 224944 225975 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding protein complement(224944..225975) Escherichia coli O157:H7 str. Sakai 913972 NP_308229.1 CDS ECs0202 NC_002695.1 226163 226738 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 226163..226738 Escherichia coli O157:H7 str. Sakai 913974 NP_308230.1 CDS dkgB NC_002695.1 232496 233299 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 232496..233299 Escherichia coli O157:H7 str. Sakai 914031 NP_308231.1 CDS ECs0204 NC_002695.1 233296 234210 R similar to YAFC_ECOLI gi|1786401 (conserved in Escherichia coli K-12); transcriptional regulator complement(233296..234210) Escherichia coli O157:H7 str. Sakai 914036 NP_308232.1 CDS ECs0205 NC_002695.1 234451 235251 D similar to YAFD_ECOLI gi|1786403 (conserved in Escherichia coli K-12); hypothetical protein 234451..235251 Escherichia coli O157:H7 str. Sakai 914037 NP_308233.1 CDS ECs0206 NC_002695.1 235329 236099 D C-terminal part (52-256 in 256 aa) is similar to YEFE_ECOLI gi|1786404 (conserved in Escherichia coli K-12); biotin synthesis protein 235329..236099 Escherichia coli O157:H7 str. Sakai 914039 NP_308234.1 CDS mltD NC_002695.1 236147 237505 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(236147..237505) Escherichia coli O157:H7 str. Sakai 914041 NP_308235.1 CDS ECs0208 NC_002695.1 237577 238332 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(237577..238332) Escherichia coli O157:H7 str. Sakai 914044 NP_308236.1 CDS ECs0209 NC_002695.1 238348 239088 D similar to YAFS_ECOLI gi|1786407 (conserved in Escherichia coli K-12); hypothetical protein 238348..239088 Escherichia coli O157:H7 str. Sakai 914047 NP_308237.1 CDS rnhA NC_002695.1 239085 239552 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(239085..239552) Escherichia coli O157:H7 str. Sakai 914053 NP_308238.1 CDS ECs0211 NC_002695.1 239617 240348 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 239617..240348 Escherichia coli O157:H7 str. Sakai 914056 NP_308239.1 CDS ECs0212 NC_002695.1 241871 242167 R hypothetical protein complement(241871..242167) Escherichia coli O157:H7 str. Sakai 914062 NP_308240.1 CDS ECs0213 NC_002695.1 242164 242613 R hypothetical protein complement(242164..242613) Escherichia coli O157:H7 str. Sakai 914064 NP_308241.1 CDS ECs0214 NC_002695.1 242616 243263 R hypothetical protein complement(242616..243263) Escherichia coli O157:H7 str. Sakai 914067 NP_308243.1 CDS ECs0216 NC_002695.1 243533 244012 R similar tohemolysin-coregulated protein Hcp [Vibrio cholerae] gi|7467495|pir||T10891, hypothetical 44.2 kD protein YhhZ [Escherichia coli (strain K-12)] gi|1176284|sp|P46855|YHHZ_ECOLI; Hcp-like protein complement(243533..244012) Escherichia coli O157:H7 str. Sakai 914071 NP_308244.1 CDS ECs0217 NC_002695.1 243978 245387 R hypothetical protein complement(243978..245387) Escherichia coli O157:H7 str. Sakai 914077 NP_308245.1 CDS ECs0218 NC_002695.1 245398 248505 R similar to IcmF protein [Legionella pneumophila] gi|7465644|pir||T18341; IcmF-like protein complement(245398..248505) Escherichia coli O157:H7 str. Sakai 914079 NP_308247.1 CDS ECs0220 NC_002695.1 248969 249763 R hypothetical protein complement(248969..249763) Escherichia coli O157:H7 str. Sakai 914081 NP_308248.1 CDS ECs0221 NC_002695.1 249760 250380 R hypothetical protein complement(249760..250380) Escherichia coli O157:H7 str. Sakai 914084 NP_308249.1 CDS ECs0222 NC_002695.1 250385 251128 R hypothetical protein complement(250385..251128) Escherichia coli O157:H7 str. Sakai 914092 NP_308250.1 CDS ECs0223 NC_002695.1 251125 253896 R similar to ATP-dependent Clp proteinase ATP-binding chains ClpB e.g. gi|7428220|pir||T07807; ATP-dependent Clp proteinase ATP-binding chain complement(251125..253896) Escherichia coli O157:H7 str. Sakai 914094 NP_308251.1 CDS ECs0224 NC_002695.1 253905 254666 R hypothetical protein complement(253905..254666) Escherichia coli O157:H7 str. Sakai 914096 NP_308252.1 CDS ECs0225 NC_002695.1 254671 256002 R similar to hypothetical protein z29f Vibrio cholerae CAA13133; hypothetical protein complement(254671..256002) Escherichia coli O157:H7 str. Sakai 914109 NP_308253.1 CDS ECs0226 NC_002695.1 256005 256529 R lipoprotein complement(256005..256529) Escherichia coli O157:H7 str. Sakai 914114 NP_308254.1 CDS ECs0227 NC_002695.1 256526 257806 R hypothetical protein complement(256526..257806) Escherichia coli O157:H7 str. Sakai 914116 NP_308255.1 CDS ECs0228 NC_002695.1 257831 258913 R hypothetical protein complement(257831..258913) Escherichia coli O157:H7 str. Sakai 914121 NP_308256.1 CDS ECs0229 NC_002695.1 258877 260727 R hypothetical protein complement(258877..260727) Escherichia coli O157:H7 str. Sakai 914124 NP_308257.1 CDS ECs0230 NC_002695.1 260731 261144 R similar to base plate protein and acidic lysozyme [coliphage T4] gi|137980|sp|P09425|VG25_BPT4; hypothetical protein complement(260731..261144) Escherichia coli O157:H7 str. Sakai 914125 NP_308258.1 CDS ECs0231 NC_002695.1 261235 262626 R similar to hypothetical 54.5 kDa protein [Edwardsiella ictaluri] gi|2708666|gb|AAB92576.1; hypothetical protein complement(261235..262626) Escherichia coli O157:H7 str. Sakai 914127 NP_308259.1 CDS ECs0232 NC_002695.1 262677 262901 R hypothetical protein complement(262677..262901) Escherichia coli O157:H7 str. Sakai 914129 NP_308260.1 CDS ECs0233 NC_002695.1 262936 263436 R similar to hypothetical protein [Escherichia coli] gi|2920642|gb|AAC32477.1; similar tohypothetical 19.5 kDa protein [Edwardsiella ictaluri] gi|2708667|gb|AAB92577.1; hypothetical protein complement(262936..263436) Escherichia coli O157:H7 str. Sakai 914131 NP_308261.1 CDS ECs0234 NC_002695.1 264133 264651 D hypothetical protein 264133..264651 Escherichia coli O157:H7 str. Sakai 914133 NP_308262.1 CDS ECs0235 NC_002695.1 264684 264821 D hypothetical protein 264684..264821 Escherichia coli O157:H7 str. Sakai 914159 NP_308263.1 CDS ECs0236 NC_002695.1 264861 267002 D similar to VgrG [Escherichia coli strain ec11] gi|2920640|gb|AAC32475.1; protein VgrG 264861..267002 Escherichia coli O157:H7 str. Sakai 914167 NP_308264.1 CDS ECs0237 NC_002695.1 267078 271292 D Rhs protein; similar to RhsH proteins e.g. [Escherichia coli strain EC45] gi|2920634|gb|AAC32471.1; RhsG core protein with extension 267078..271292 Escherichia coli O157:H7 str. Sakai 914169 NP_308265.1 CDS ECs0238 NC_002695.1 271295 271906 D similar to YbeQ [Escherichia coli] gi|3025010|sp|P77234; similar toYibG [Escherichia coli] gi|418454|sp|P32106|YIBG_ECOLI; hypothetical protein 271295..271906 Escherichia coli O157:H7 str. Sakai 914172 NP_308266.1 CDS ECs0239 NC_002695.1 271928 272110 D hypothetical protein 271928..272110 Escherichia coli O157:H7 str. Sakai 914174 NP_308267.1 CDS ECs0240 NC_002695.1 272254 272544 D hypothetical protein 272254..272544 Escherichia coli O157:H7 str. Sakai 914178 NP_308268.1 CDS ECs0241 NC_002695.1 272652 273788 D similar to H repeat-associated proteins e.g. [Escherichia coli RhsB element] gi|140772|sp|P28912; H repeat-containing protein 272652..273788 Escherichia coli O157:H7 str. Sakai 914217 NP_308269.1 CDS ECs0242 NC_002695.1 273791 275551 D Rhs protein; similar to Rhs core proteins e.g. RhsE [Escherichia coli] gi|2507113|sp|P24211|RHSE_ECOLI; Rhs core protein 273791..275551 Escherichia coli O157:H7 str. Sakai 914218 NP_308270.1 CDS ECs0243 NC_002695.1 275535 275705 D similar to N-terminal parts of hypothetical proteins e.g. ORF E2 in Rhs element [Escherichia coli] gi|2851489|sp|P31991; hypothetical protein 275535..275705 Escherichia coli O157:H7 str. Sakai 914228 NP_308271.1 CDS ECs0244 NC_002695.1 275753 276016 D similar to C-terminal parts of hypothetical proteins e.g. ORF E2 in Rhs element [Escherichia coli] gi|2851489|sp|P31991; hypothetical protein 275753..276016 Escherichia coli O157:H7 str. Sakai 914250 NP_308272.1 CDS ECs0245 NC_002695.1 276197 277369 D similar to H repeat-associated proteins e.g. [Escherichia coli RhsB element] gi|7465875|pir||E64898; H repeat-containing protein 276197..277369 Escherichia coli O157:H7 str. Sakai 914277 NP_308273.1 CDS ECs0246 NC_002695.1 277487 278257 R similar to YAFV_ECOLI gi|1786412 (conserved in Escherichia coli K-12); hypothetical protein complement(277487..278257) Escherichia coli O157:H7 str. Sakai 914330 NP_308274.1 CDS ECs0247 NC_002695.1 278411 278884 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 278411..278884 Escherichia coli O157:H7 str. Sakai 914333 NP_308275.2 CDS fadE NC_002695.1 278927 281371 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(278927..281371) Escherichia coli O157:H7 str. Sakai 914334 NP_308276.1 CDS gmhA NC_002695.1 281611 282189 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 281611..282189 Escherichia coli O157:H7 str. Sakai 914335 NP_308277.1 CDS ECs0250 NC_002695.1 282294 283061 D similar to YAFJ_ECOLI gi|1786417 (conserved in Escherichia coli K-12); amidotransferase 282294..283061 Escherichia coli O157:H7 str. Sakai 914337 NP_308278.1 CDS ECs0251 NC_002695.1 283032 283772 R similar to YAFK_ECOLI gi|1786418 (conserved in Escherichia coli K-12); hypothetical protein complement(283032..283772) Escherichia coli O157:H7 str. Sakai 914338 NP_308279.1 CDS ECs0252 NC_002695.1 283928 284188 R similar to YAFQ_ECOLI gi|1786419 (conserved in Escherichia coli K-12); hypothetical protein complement(283928..284188) Escherichia coli O157:H7 str. Sakai 914339 NP_308280.1 CDS ECs0253 NC_002695.1 284207 284467 R damage-inducible protein; similar to DINJ_ECOLI gi|1786420 (conserved in Escherichia coli K-12); protein DinJ complement(284207..284467) Escherichia coli O157:H7 str. Sakai 914340 NP_308281.1 CDS ECs0254 NC_002695.1 284677 285426 D similar to YAFL_ECOLI gi|1786421 (conserved in Escherichia coli K-12); lipoprotein 284677..285426 Escherichia coli O157:H7 str. Sakai 914343 NP_308282.1 CDS ECs0255 NC_002695.1 285602 285898 D similar to N-terminal part (1-98 in 165 aa) of YAFM_ECOLI gi|1786422; hypothetical protein 285602..285898 Escherichia coli O157:H7 str. Sakai 914344 NP_308283.1 CDS ECs0257 NC_002695.1 286244 287983 R similar to FHIA_ECOLI gi|1786423 (conserved in Escherichia coli K-12); FhiA protein complement(286244..287983) Escherichia coli O157:H7 str. Sakai 914346 NP_308284.1 CDS ECs0256 NC_002695.1 287928 288713 D similar to MBHA_ECOLI gi|1786424 (conserved in Escherichia coli K-12); hypothetical protein 287928..288713 Escherichia coli O157:H7 str. Sakai 914347 NP_308285.1 CDS ECs0258 NC_002695.1 288784 289839 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 288784..289839 Escherichia coli O157:H7 str. Sakai 914349 NP_308286.1 CDS ECs0259 NC_002695.1 289891 290184 D similar to YAFN_ECOLI gi|1786426 (conserved in Escherichia coli K-12); antitoxin of the YafO-YafN toxin-antitoxin system 289891..290184 Escherichia coli O157:H7 str. Sakai 914352 NP_308287.1 CDS ECs0260 NC_002695.1 290187 290585 D YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 290187..290585 Escherichia coli O157:H7 str. Sakai 914353 NP_308288.1 CDS ECs0261 NC_002695.1 290595 291047 D similar to YAFP_ECOLI gi|1786428 (conserved in Escherichia coli K-12); hypothetical protein 290595..291047 Escherichia coli O157:H7 str. Sakai 914355 NP_308289.1 CDS ECs0262 NC_002695.1 291354 291620 D similar to B0235_ECOLI gi|1786430 (conserved in Escherichia coli K-12); hypothetical protein 291354..291620 Escherichia coli O157:H7 str. Sakai 914358 NP_308290.1 CDS prfH NC_002695.1 291589 292089 D similar to release factor 1 and 2; peptide chain release factor-like protein 291589..292089 Escherichia coli O157:H7 str. Sakai 914361 NP_308291.1 CDS ECs0264 NC_002695.1 292146 293603 R similar to PEPD_ECOLI gi|1786432 (conserved in Escherichia coli K-12); hypothetical protein complement(292146..293603) Escherichia coli O157:H7 str. Sakai 914362 NP_308292.1 CDS ECs0265 NC_002695.1 293864 294322 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 293864..294322 Escherichia coli O157:H7 str. Sakai 914363 NP_308293.1 CDS frsA NC_002695.1 294414 295658 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 294414..295658 Escherichia coli O157:H7 str. Sakai 914364 NP_308294.1 CDS ECs0267 NC_002695.1 295716 296117 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 295716..296117 Escherichia coli O157:H7 str. Sakai 914365 NP_308295.1 CDS ECs0268 NC_002695.1 296156 297211 R outer membrane pore protein; similar to PHOE_ECOLI gi|1786436 (conserved in Escherichia coli K-12); outer membrane phosphoporin protein E complement(296156..297211) Escherichia coli O157:H7 str. Sakai 914366 NP_308296.1 CDS ECs0269 NC_002695.1 297499 298602 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 297499..298602 Escherichia coli O157:H7 str. Sakai 914367 NP_308297.1 CDS proA NC_002695.1 298614 299867 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 298614..299867 Escherichia coli O157:H7 str. Sakai 914368 NP_308298.1 CDS ECs0271 NC_002695.1 300072 301046 R similar to integrases e.g. [Shigella flexneri bacteriophage V] gi|2465477|gb|AAB72135.1; integrase complement(300072..301046) Escherichia coli O157:H7 str. Sakai 914370 NP_308299.1 CDS ECs0272 NC_002695.1 300937 301182 R similar to transcription antitermination protein N [Bacteriophage lambda] gi|73111|pir||VNBPL; transcription antitermination protein complement(300937..301182) Escherichia coli O157:H7 str. Sakai 914371 NP_308300.1 CDS ECs0273 NC_002695.1 301422 301811 R similar to N-terminal part of hypothetical proteins HP1334 [Helicobacter pylori (strain 26695)] gi|7464516|pir||F64686, hypothetical protein [Neisseria meningitidis] gi|6900422|e; hypothetical protein complement(301422..301811) Escherichia coli O157:H7 str. Sakai 914372 NP_308301.1 CDS ECs0274 NC_002695.1 301939 302652 R similar to prophage repressor CI e.g. [Bacteriophage HK97] gi|6901592|gb|AAF31095.1|AF069529_8 (AF069529); hypothetical protein complement(301939..302652) Escherichia coli O157:H7 str. Sakai 914373 NP_308302.1 CDS ECs0275 NC_002695.1 302753 302953 D similar to regulatory protein Cro [phage lambda] gi|73101|pir||RCBPL, similar toCro proteins e.g. [Bacteriophage HK97] gi|6901626|gb|AAF31129.1; Cro 302753..302953 Escherichia coli O157:H7 str. Sakai 914374 NP_308303.1 CDS ECs0276 NC_002695.1 303072 303365 D regulatory protein; similar to regulatory protein cII [Bacteriophage lambda] gi|73106|pir||QCBP2L; hypothetical protein 303072..303365 Escherichia coli O157:H7 str. Sakai 914375 NP_308307.1 CDS ECs0280 NC_002695.1 304628 305422 D similar to tail fiber proteins e.g. [Bacteriophage HK97] gi|6901608|gb|AAF31111.1| (AF069529); Sc/SvQ proteins (DNA inversion product) [Escherichia coli plasmid p15B]; tail fiber protein 304628..305422 Escherichia coli O157:H7 str. Sakai 914379 NP_308308.1 CDS ECs0281 NC_002695.1 305422 306015 D similar to hypothetical proteins e.g. YcfA protein [Escherichia coli] gi|2506641|sp|P09153|YCFA_ECOLI; Gp29 [Bacteriophage HK97] gi|6901609|gb|AAF31112.1; T protein [Escherichia col; hypothetical protein 305422..306015 Escherichia coli O157:H7 str. Sakai 914380 NP_308309.1 CDS ECs0282 NC_002695.1 305987 306430 R similar to hypothetical proteins e.g. YfdK [Escherichia coli(strain K-12)] gi|3915468|sp|P77656|YFDK_ECOLI; hypothetical protein complement(305987..306430) Escherichia coli O157:H7 str. Sakai 914381 NP_308310.1 CDS ECs0283 NC_002695.1 306451 306861 R similar to hypothetical proteins e.g. YfdL [Escherichia coli (strain K-12)] gi|2495635|sp|P76508|YFDL_ECOLI; tail fiber protein YcfE [Escherichia coli cryptic prophage e14] gi|7444558|p; tail fiber protein complement(306451..306861) Escherichia coli O157:H7 str. Sakai 914382 NP_308311.1 CDS ECs0284 NC_002695.1 306891 307445 D similar to DNA-invertases e.g. Pin [Escherichia coli] gi|72978|pir||JWEC; DNA-invertase 306891..307445 Escherichia coli O157:H7 str. Sakai 914383 NP_308312.1 CDS ECs0285 NC_002695.1 307503 308276 R similar to hypothetical protein [Deinococcus radiodurans (strain R1)] gi|7472205|pir||B75431; hypothetical protein complement(307503..308276) Escherichia coli O157:H7 str. Sakai 914384 NP_308314.1 CDS ECs0287 NC_002695.1 309100 309843 D similar to transcription regulators e.g. AraC family transcriptional regulator YdeO gi|6176587|sp|P76135|YDEO_ECOLI; transcriptional regulator 309100..309843 Escherichia coli O157:H7 str. Sakai 914386 NP_308315.1 CDS ECs0288 NC_002695.1 309885 310238 R similar to C-terminal parts of hypothetical proteins e.g. [Escherichia coli insertion sequence IS2] gi|140808|sp|P19777|YI22_ECOLI; may be disrupted; hypothetical protein complement(309885..310238) Escherichia coli O157:H7 str. Sakai 914387 NP_308316.1 CDS ECs0289 NC_002695.1 310806 311987 D similar to integrases e.g. [phage phi-R73] gi|93827|pir||A42465; integrase 310806..311987 Escherichia coli O157:H7 str. Sakai 914388 NP_308317.1 CDS ECs0290 NC_002695.1 311991 312407 D hypothetical protein 311991..312407 Escherichia coli O157:H7 str. Sakai 914389 NP_308318.1 CDS ECs0291 NC_002695.1 312380 312997 D hypothetical protein 312380..312997 Escherichia coli O157:H7 str. Sakai 914390 NP_308319.1 CDS ECs0292 NC_002695.1 312997 313455 D hypothetical protein 312997..313455 Escherichia coli O157:H7 str. Sakai 914391 NP_308320.1 CDS ECs0293 NC_002695.1 313448 314080 D hypothetical protein 313448..314080 Escherichia coli O157:H7 str. Sakai 914392 NP_308321.1 CDS ECs0294 NC_002695.1 314111 314701 D similar to hypothetical protein PFB0765w [malaria parasite] gi|7494317|pir||E71606; hypothetical protein 314111..314701 Escherichia coli O157:H7 str. Sakai 914393 NP_308322.1 CDS ECs0295 NC_002695.1 314701 315267 D hypothetical protein 314701..315267 Escherichia coli O157:H7 str. Sakai 914394 NP_308323.1 CDS ECs0296 NC_002695.1 315677 315949 R probable transcription activator; similar to Ogr family e.g. LsrS [Rahnella aquatilis] gi|93826|pir||E42465; delta protein [phage phi-R73] gi|93826|pir||E42465; Ogr family transcription activator complement(315677..315949) Escherichia coli O157:H7 str. Sakai 914395 NP_308324.1 CDS ECs0297 NC_002695.1 315955 316506 R probable polarity suppression protein (amber mutation-suppression protein); similar to Psu like proteins e.g. Psu [Bacteriophage P4] gi|1351414|sp|P05460|VPSU_BPP4; polarity suppression protein complement(315955..316506) Escherichia coli O157:H7 str. Sakai 914396 NP_308325.1 CDS ECs0298 NC_002695.1 316503 317255 R head size determination, similar to head size determination proteins e.g. Sid [phage phi-R73] gi|93821|pir||F42465; head size determination protein complement(316503..317255) Escherichia coli O157:H7 str. Sakai 914397 NP_944502.1 CDS ECs5374 NC_002695.1 317658 317828 D hypothetical protein 317658..317828 Escherichia coli O157:H7 str. Sakai 2693817 NP_308326.1 CDS ECs0299 NC_002695.1 318189 318449 D probable DNA binding protein, similar to hypothetical proteins e.g. DNA binding protein ORF88 [satellite phage P4] gi|140147|sp|P12552|Y9K_BPP4; DNA binding protein 318189..318449 Escherichia coli O157:H7 str. Sakai 914398 NP_308327.1 CDS ECs0300 NC_002695.1 318446 319003 D similar to CI repressors e.g. [Bacteriophage P4] gi|1262833|emb|CAA35902.1; CI repressor 318446..319003 Escherichia coli O157:H7 str. Sakai 914399 NP_308328.1 CDS ECs0301 NC_002695.1 319000 319221 D hypothetical protein 319000..319221 Escherichia coli O157:H7 str. Sakai 914400 NP_308329.1 CDS ECs0302 NC_002695.1 319221 319544 D copy number control protein; similar to orf106 [satellite phage P4] gi|75896|pir||QQBPP4; Cnr-like protein 319221..319544 Escherichia coli O157:H7 str. Sakai 914401 NP_308330.1 CDS ECs0303 NC_002695.1 319558 321891 D similar to DNA primases e.g. alpha gene product [satellite phage P4] gi|130905|sp|P10277|PRIM_BPP4; DNA primase 319558..321891 Escherichia coli O157:H7 str. Sakai 914402 NP_308331.1 CDS ECs0304 NC_002695.1 322024 322980 R similar to hypothetical protein sll1401 [Synechocystis sp. (strain PCC 6803)] gi|7470073|pir||S74462; hypothetical protein complement(322024..322980) Escherichia coli O157:H7 str. Sakai 914403 NP_308332.1 CDS ECs0305 NC_002695.1 323656 324405 R similar to YAGP_ECOLI gi|1786476; hypothetical protein complement(323656..324405) Escherichia coli O157:H7 str. Sakai 914404 NP_308333.1 CDS ECs0306 NC_002695.1 324654 325376 D similar to oxidoreductases e.g. [Streptomyces coelicolor A3(2)] gi|6137024|emb|CAB59579.1; oxidoreductase 324654..325376 Escherichia coli O157:H7 str. Sakai 914405 NP_308334.1 CDS ECs0307 NC_002695.1 325543 325821 D hypothetical protein 325543..325821 Escherichia coli O157:H7 str. Sakai 914406 NP_308336.1 CDS ECs0309 NC_002695.1 326524 327426 R similar to transcriptional regulators e.g. [Xylella fastidiosa] gi|9106842|gb|AAF84577.1|AE003999_5; transcriptional regulator complement(326524..327426) Escherichia coli O157:H7 str. Sakai 914408 NP_308337.1 CDS ECs0310 NC_002695.1 327594 328730 D similar to hypothetical protein [Pseudomonas aeruginosa] gi|732227|sp|Q01609|YODE_PSEAE; hypothetical protein 327594..328730 Escherichia coli O157:H7 str. Sakai 914409 NP_308338.1 CDS ECs0311 NC_002695.1 328806 329999 D similar to transporters e.g. OpdE [Pseudomonas aeruginosa] gi|400678|sp|Q01602|OPDE_PSEAE; transporter 328806..329999 Escherichia coli O157:H7 str. Sakai 914410 NP_308340.1 CDS ECs0313 NC_002695.1 330178 331134 R similar to YAGQ_ECOLI gi|1786477 (conserved in Escherichia coli K-12); hypothetical protein complement(330178..331134) Escherichia coli O157:H7 str. Sakai 914412 NP_308341.1 CDS ECs0314 NC_002695.1 331144 333342 R similar to YAGR_ECOLI gi|1786478 (conserved in Escherichia coli K-12); hypothetical protein complement(331144..333342) Escherichia coli O157:H7 str. Sakai 914413 NP_308342.1 CDS ECs0315 NC_002695.1 333339 334295 R similar to YAGS_ECOLI gi|1786479 (conserved in Escherichia coli K-12); hypothetical protein complement(333339..334295) Escherichia coli O157:H7 str. Sakai 914414 NP_308343.1 CDS ECs0316 NC_002695.1 334292 334981 R similar to YAGT_ECOLI gi|1786480 (conserved in Escherichia coli K-12); xanthine dehydrogenase iron-sulfur-binding subunit complement(334292..334981) Escherichia coli O157:H7 str. Sakai 914415 NP_308344.1 CDS ECs0317 NC_002695.1 335399 336013 D similar to YAGU_ECOLI gi|1786481 (conserved in Escherichia coli K-12); hypothetical protein 335399..336013 Escherichia coli O157:H7 str. Sakai 914416 NP_308345.1 CDS ECs0318 NC_002695.1 336261 336590 R similar to YKGJ_ECOLI gi|2367105 (conserved in Escherichia coli K-12); ferredoxin complement(336261..336590) Escherichia coli O157:H7 str. Sakai 914417 NP_308346.1 CDS ECs0319 NC_002695.1 336903 337658 R similar to YAGV_ECOLI gi|1786482 (conserved in Escherichia coli K-12); hypothetical protein complement(336903..337658) Escherichia coli O157:H7 str. Sakai 914418 NP_308347.1 CDS ECs0320 NC_002695.1 337582 339225 R similar to YAGW_ECOLI gi|1786483 (conserved in Escherichia coli K-12); receptor complement(337582..339225) Escherichia coli O157:H7 str. Sakai 914419 NP_308348.1 CDS ECs0321 NC_002695.1 339215 341740 R similar to YAGX_ECOLI gi|1786484 (conserved in Escherichia coli K-12); hypothetical protein complement(339215..341740) Escherichia coli O157:H7 str. Sakai 914420 NP_308349.1 CDS ECs0322 NC_002695.1 341766 342434 R similar to YAGY_ECOLI gi|1786485 (conserved in Escherichia coli K-12); hypothetical protein complement(341766..342434) Escherichia coli O157:H7 str. Sakai 914421 NP_308350.1 CDS ECs0323 NC_002695.1 342492 343079 R similar to YAGZ_ECOLI gi|1786486 (conserved in Escherichia coli K-12); hypothetical protein complement(342492..343079) Escherichia coli O157:H7 str. Sakai 914422 NP_308351.1 CDS ECs0324 NC_002695.1 343154 343744 R similar to YKGK_ECOLI gi|2367106 (conserved in Escherichia coli K-12); regulator complement(343154..343744) Escherichia coli O157:H7 str. Sakai 914423 NP_308353.1 CDS ECs0326 NC_002695.1 344521 344712 D similar to YKGL_ECOLI gi|2367107 (conserved in Escherichia coli K-12); hypothetical protein 344521..344712 Escherichia coli O157:H7 str. Sakai 914425 NP_944503.1 CDS rpmJ NC_002695.1 344782 344922 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 complement(344782..344922) Escherichia coli O157:H7 str. Sakai 2693818 NP_308354.1 CDS rpmE2 NC_002695.1 344922 345185 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(344922..345185) Escherichia coli O157:H7 str. Sakai 914426 NP_308355.1 CDS ECs0328 NC_002695.1 345428 345829 D similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933}] gi|3414881|gb|AAC31492.1; hypothetical protein 345428..345829 Escherichia coli O157:H7 str. Sakai 914427 NP_308356.1 CDS ECs0329 NC_002695.1 345826 346173 D similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933}] gi|3288157|emb|CAA11510.1; hypothetical protein 345826..346173 Escherichia coli O157:H7 str. Sakai 914428 NP_308357.1 CDS ECs0330 NC_002695.1 346223 347761 D similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933}] gi|3414883|gb|AAC31494.1; hypothetical protein 346223..347761 Escherichia coli O157:H7 str. Sakai 914429 NP_308358.1 CDS ECs0331 NC_002695.1 348573 349715 R similar to YqiG [Bacillus subtilis] gi|1731054|sp|P54524|YQIG_BACSU; NADH-dependent flavin oxidoreductase complement(348573..349715) Escherichia coli O157:H7 str. Sakai 914430 NP_308359.1 CDS ECs0332 NC_002695.1 349950 350870 R similar to hypothetical protein [Escherichia coli K-12] gi|3183244|sp|P76049|YCJY_ECOLI; hypothetical protein complement(349950..350870) Escherichia coli O157:H7 str. Sakai 914431 NP_308360.1 CDS ECs0333 NC_002695.1 351027 351953 D similar to transcriptional regulators e.g. [Escherichia coli] gi|2495398|sp|P75836|YCAN_ECOLI; transcriptional regulator 351027..351953 Escherichia coli O157:H7 str. Sakai 914432 NP_308361.1 CDS ECs0334 NC_002695.1 352241 352597 R hypothetical protein complement(352241..352597) Escherichia coli O157:H7 str. Sakai 914433 NP_308362.1 CDS ECs0335 NC_002695.1 352790 353365 R similar to oxidoreductase, [Thermotoga maritima] gi|7431104|pir||A72308; oxidoreductase complement(352790..353365) Escherichia coli O157:H7 str. Sakai 914434 NP_308363.1 CDS ECs0336 NC_002695.1 353931 358184 D similar to probable membrane protein b1978 [Escherichia coli] gi|7466779|pir||D64962; similar toinvasins e.g. [Yersinia pestis] gi|726319|gb|AAA96352.1; invasin 353931..358184 Escherichia coli O157:H7 str. Sakai 914435 NP_308364.1 CDS ECs0337 NC_002695.1 358305 359195 R similar to probable transcription regulator YkgA [Escherichia coli] gi|2495375|sp|P77601|YKGA_ECOLI; transcriptional regulator complement(358305..359195) Escherichia coli O157:H7 str. Sakai 914436 NP_308365.2 CDS ECs0338 NC_002695.1 359396 360280 D similar to reductases e.g. oxidoreductase [Thermotoga maritima] gi|7431104|pir||A72308; reductase 359396..360280 Escherichia coli O157:H7 str. Sakai 914437 NP_308366.1 CDS ECs0340 NC_002695.1 360440 361033 R similar to YKGB_ECOLI gi|1786492 (conserved in Escherichia coli K-12); hypothetical protein complement(360440..361033) Escherichia coli O157:H7 str. Sakai 914438 NP_308368.1 CDS ECs0341 NC_002695.1 361045 361296 R similar to YKGI_ECOLI gi|1786494 (conserved in Escherichia coli K-12); hypothetical protein complement(361045..361296) Escherichia coli O157:H7 str. Sakai 914440 NP_308369.2 CDS ECs0342 NC_002695.1 361390 362715 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(361390..362715) Escherichia coli O157:H7 str. Sakai 914441 NP_308370.1 CDS ECs0343 NC_002695.1 362941 363795 D similar to YKGD_ECOLI gi|1786496 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 362941..363795 Escherichia coli O157:H7 str. Sakai 914442 NP_308371.1 CDS ECs0344 NC_002695.1 364322 365041 D similar to YKGE_ECOLI gi|1786497 (conserved in Escherichia coli K-12); dehydrogenase subunit 364322..365041 Escherichia coli O157:H7 str. Sakai 914443 NP_308372.1 CDS ECs0345 NC_002695.1 365052 366479 D similar to YKGF_ECOLI gi|1786498 (conserved in Escherichia coli K-12); hypothetical protein 365052..366479 Escherichia coli O157:H7 str. Sakai 914444 NP_308373.2 CDS ECs0346 NC_002695.1 366472 367167 D similar to YKGG_ECOLI gi|1786499 (conserved in Escherichia coli K-12); hypothetical protein 366472..367167 Escherichia coli O157:H7 str. Sakai 914446 NP_308374.1 CDS ECs0347 NC_002695.1 367122 367334 R similar to B0309_ECOLI gi|1786500 (conserved in Escherichia coli K-12); hypothetical protein complement(367122..367334) Escherichia coli O157:H7 str. Sakai 914447 NP_308375.1 CDS ECs0348 NC_002695.1 367662 368078 R similar to YKGH_ECOLI gi|1786502; hypothetical protein complement(367662..368078) Escherichia coli O157:H7 str. Sakai 914448 NP_308376.1 CDS ECs0349 NC_002695.1 368260 368508 R similar to hypothetical protein YaiU [Escherichia coli] gi|2495526|sp|P75700|YAIU_ECOLI; hypothetical protein complement(368260..368508) Escherichia coli O157:H7 str. Sakai 914449 NP_308377.1 CDS ECs0350 NC_002695.1 368426 369520 R similar to high molecular weight adhesin e.g. HmwA [Haemophilus influenzae] gi|5929966|gb|AAD56660.1|AF180944_1; adhesin complement(368426..369520) Escherichia coli O157:H7 str. Sakai 914451 NP_308378.1 CDS ECs0351 NC_002695.1 369562 370323 R hypothetical protein complement(369562..370323) Escherichia coli O157:H7 str. Sakai 914452 NP_308379.1 CDS ECs0352 NC_002695.1 370477 370848 R similar to hypothetical protein [Escherichia coli] gi|2506596|sp|P21514|YAHA_ECOLI; similar to regulators e.g. BvgA [Bordetella bronchiseptic] gi|115157|sp|P16574|BVGA_BORPE; hypothetical protein complement(370477..370848) Escherichia coli O157:H7 str. Sakai 914453 NP_308380.1 CDS ECs0353 NC_002695.1 371104 371271 R hypothetical protein complement(371104..371271) Escherichia coli O157:H7 str. Sakai 914454 NP_944504.1 CDS ECs5376 NC_002695.1 372970 373221 D hypothetical protein 372970..373221 Escherichia coli O157:H7 str. Sakai 2693819 NP_308384.1 CDS ECs0357 NC_002695.1 373223 374911 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(373223..374911) Escherichia coli O157:H7 str. Sakai 914458 NP_308385.1 CDS ECs0358 NC_002695.1 374925 376397 R catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase complement(374925..376397) Escherichia coli O157:H7 str. Sakai 914459 NP_308386.2 CDS ECs0359 NC_002695.1 376411 377016 R HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI complement(376411..377016) Escherichia coli O157:H7 str. Sakai 914460 NP_308387.1 CDS ECs0360 NC_002695.1 377127 379160 D proton-motive-force-driven choline transporter; choline transport protein BetT 377127..379160 Escherichia coli O157:H7 str. Sakai 914461 NP_308389.1 CDS ECs0362 NC_002695.1 379734 383717 D similar to IgA1 protease homolog MisL [Salmonella typhimurium pathogenicity island SPI-3] gi|4324610|gb|AAD16954.1|; similar to VirG [Shigella flexneri] gi|96922|pir||A32247; probable adhesin; AidA-I adhesin precursor e.g. [Escherichia coli plasmid F] gi|8918851|dbj|BAA97898.1; AidA-I adhesin-like protein 379734..383717 Escherichia coli O157:H7 str. Sakai 914463 NP_308390.1 CDS ECs0363 NC_002695.1 383859 384947 D similar to YAHA_ECOLI gi|1786507 (conserved in Escherichia coli K-12); hypothetical protein 383859..384947 Escherichia coli O157:H7 str. Sakai 914464 NP_308393.1 CDS ECs0366 NC_002695.1 386012 386314 R similar to YAHC_ECOLI gi|1786509 (conserved in Escherichia coli K-12); hypothetical protein complement(386012..386314) Escherichia coli O157:H7 str. Sakai 914467 NP_308394.1 CDS ECs0367 NC_002695.1 386777 387382 D similar to YAHD_ECOLI gi|1786511 (conserved in Escherichia coli K-12); transcription factor 386777..387382 Escherichia coli O157:H7 str. Sakai 914468 NP_308395.1 CDS ECs0368 NC_002695.1 387422 388285 D similar to YAHE_ECOLI gi|1786512 (conserved in Escherichia coli K-12); hypothetical protein 387422..388285 Escherichia coli O157:H7 str. Sakai 914469 NP_308396.1 CDS ECs0369 NC_002695.1 388275 389822 D similar to YAHF_ECOLI gi|1786513 (conserved in Escherichia coli K-12); oxidoreductase subunit 388275..389822 Escherichia coli O157:H7 str. Sakai 914470 NP_308397.1 CDS ECs0370 NC_002695.1 389822 391240 D similar to YAHG_ECOLI gi|1786514 (conserved in Escherichia coli K-12); hypothetical protein 389822..391240 Escherichia coli O157:H7 str. Sakai 914471 NP_308398.1 CDS ECs0371 NC_002695.1 391266 391586 D similar to YAHH_ECOLI gi|1786515 (conserved in Escherichia coli K-12); hypothetical protein 391266..391586 Escherichia coli O157:H7 str. Sakai 914472 NP_308399.1 CDS ECs0372 NC_002695.1 391755 392705 D forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 391755..392705 Escherichia coli O157:H7 str. Sakai 914473 NP_308400.1 CDS ECs0373 NC_002695.1 392715 394097 D metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 392715..394097 Escherichia coli O157:H7 str. Sakai 914474 NP_944505.1 CDS ECs5377 NC_002695.1 394366 394806 D hypothetical protein 394366..394806 Escherichia coli O157:H7 str. Sakai 2693814 NP_308401.1 CDS ECs0374 NC_002695.1 395057 396043 D similar to sugar-binding proteins e.g. b1516 [Escherichia coli] gi|7466925|pir||G64905; sugar-binding protein 395057..396043 Escherichia coli O157:H7 str. Sakai 914475 NP_308402.1 CDS ECs0375 NC_002695.1 396092 396352 D similar to N-terminal part of ABC transporter ATP-binding proteins e.g. [Streptomyces coelicolor A3(2)] gi|7479110|pir||T34924; ABC transporter ATP-binding protein 396092..396352 Escherichia coli O157:H7 str. Sakai 914476 NP_308403.1 CDS ECs0376 NC_002695.1 396464 397576 D similar to C-terminal part of sugar ABC transporter ATP-binding proteins e.g. [Bacillus subtilis] gi|7404442|sp|P36947|RBSA_BACSU; ABC transporter ATP-binding protein 396464..397576 Escherichia coli O157:H7 str. Sakai 914477 NP_308404.1 CDS ECs0377 NC_002695.1 397569 398540 D similar to ABC transporter permeases e.g. RbsC[Bacillus subtilis] gi|7446897|pir||B69690; [Escherichia coli] gi|400960|sp|P04984|RBSC_ECOLI; ABC transporter permease 397569..398540 Escherichia coli O157:H7 str. Sakai 914478 NP_308405.1 CDS ECs0378 NC_002695.1 398537 399493 D similar to ABC transporter permeases e.g. RbsC [Escherichia coli] gi|78833|pir||C26304; [Bacillus subtilis] gi|7446897|pir||B69690; ABC transporter permease 398537..399493 Escherichia coli O157:H7 str. Sakai 914479 NP_308406.1 CDS ECs0379 NC_002695.1 399580 400629 D similar to YAHK_ECOLI gi|1786518 (conserved in Escherichia coli K-12); oxidoreductase 399580..400629 Escherichia coli O157:H7 str. Sakai 914480 NP_308407.1 CDS ECs0380 NC_002695.1 400872 401687 D similar to YAHL_ECOLI gi|1786519 (conserved in Escherichia coli K-12); hypothetical protein 400872..401687 Escherichia coli O157:H7 str. Sakai 914481 NP_308409.2 CDS ECs0382 NC_002695.1 402365 403012 R similar to YAHN_ECOLI gi|1786522 (conserved in Escherichia coli K-12); cytochrome subunit of dehydrogenase complement(402365..403012) Escherichia coli O157:H7 str. Sakai 914484 NP_308410.1 CDS ECs0383 NC_002695.1 403183 403458 D similar to YAHO_ECOLI gi|1786523 (conserved in Escherichia coli K-12); hypothetical protein 403183..403458 Escherichia coli O157:H7 str. Sakai 914485 NP_308411.1 CDS ECs0384 NC_002695.1 403556 405142 R similar to PRPR_ECOLI gi|1786524 (conserved in Escherichia coli K-12); regulator for prp operon complement(403556..405142) Escherichia coli O157:H7 str. Sakai 914486 NP_308412.1 CDS prpB NC_002695.1 405381 406271 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 405381..406271 Escherichia coli O157:H7 str. Sakai 914487 NP_308413.1 CDS ECs0386 NC_002695.1 406427 407596 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 406427..407596 Escherichia coli O157:H7 str. Sakai 914488 NP_308414.1 CDS prpD NC_002695.1 407630 409081 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 407630..409081 Escherichia coli O157:H7 str. Sakai 914489 NP_308415.1 CDS prpE NC_002695.1 409121 411007 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 409121..411007 Escherichia coli O157:H7 str. Sakai 914490 NP_308416.1 CDS codB NC_002695.1 411901 413160 D similar to CODB_ECOLI gi|1786530 (conserved in Escherichia coli K-12); cytosine permease 411901..413160 Escherichia coli O157:H7 str. Sakai 914491 NP_308417.1 CDS ECs0390 NC_002695.1 413150 414433 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 413150..414433 Escherichia coli O157:H7 str. Sakai 914492 NP_308418.1 CDS ECs0391 NC_002695.1 414566 415465 R controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR complement(414566..415465) Escherichia coli O157:H7 str. Sakai 914493 NP_308419.1 CDS ECs0392 NC_002695.1 415575 416234 D similar to CYNT_ECOLI gi|1786534 (conserved in Escherichia coli K-12); carbonic anhydrase 415575..416234 Escherichia coli O157:H7 str. Sakai 914494 NP_308420.1 CDS ECs0393 NC_002695.1 416265 416735 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 416265..416735 Escherichia coli O157:H7 str. Sakai 914495 NP_308421.1 CDS cynX NC_002695.1 416768 417922 D MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 416768..417922 Escherichia coli O157:H7 str. Sakai 914496 NP_308422.1 CDS lacA NC_002695.1 418025 418636 R transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase complement(418025..418636) Escherichia coli O157:H7 str. Sakai 914497 NP_308423.1 CDS lacY NC_002695.1 418702 419955 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(418702..419955) Escherichia coli O157:H7 str. Sakai 914498 NP_308424.1 CDS lacZ NC_002695.1 420007 423081 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(420007..423081) Escherichia coli O157:H7 str. Sakai 914499 NP_308425.2 CDS lacI NC_002695.1 423204 424295 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(423204..424295) Escherichia coli O157:H7 str. Sakai 914500 NP_308426.1 CDS ECs0399 NC_002695.1 424323 425276 R similar to araC-family transcriptional regulators e.g. AdpA [Streptomyces coelicolor A3(2)] gi|7544056|emb|CAB87229.1; transcriptional regulator complement(424323..425276) Escherichia coli O157:H7 str. Sakai 914501 NP_308427.1 CDS ECs0400 NC_002695.1 425296 426084 R similar to YDDR_BACSU gi|7474951|pir||H69776; hypothetical protein complement(425296..426084) Escherichia coli O157:H7 str. Sakai 914502 NP_308428.1 CDS ECs0401 NC_002695.1 426187 427134 R activator of 3-phenylpropionic acid catabolism; MhpR family transcriptional regulator complement(426187..427134) Escherichia coli O157:H7 str. Sakai 914503 NP_308429.1 CDS mhpA NC_002695.1 427211 428875 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 427211..428875 Escherichia coli O157:H7 str. Sakai 914504 NP_308430.1 CDS mhpB NC_002695.1 428877 429821 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 428877..429821 Escherichia coli O157:H7 str. Sakai 914505 NP_308431.2 CDS ECs0404 NC_002695.1 429824 430705 D similar to MHPC_ECOLI gi|1786545 (conserved in Escherichia coli K-12); 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 429824..430705 Escherichia coli O157:H7 str. Sakai 914506 NP_308432.1 CDS mhpD NC_002695.1 430715 431524 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 430715..431524 Escherichia coli O157:H7 str. Sakai 914507 NP_308433.1 CDS ECs0406 NC_002695.1 431521 432471 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 431521..432471 Escherichia coli O157:H7 str. Sakai 914508 NP_308434.1 CDS ECs0407 NC_002695.1 432468 433481 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 432468..433481 Escherichia coli O157:H7 str. Sakai 914509 NP_308435.2 CDS ECs0408 NC_002695.1 433657 434868 D similar to MHPT_ECOLI gi|1786549 (conserved in Escherichia coli K-12); 3-hydroxyphenylpropionic transporter MhpT 433657..434868 Escherichia coli O157:H7 str. Sakai 914510 NP_308436.2 CDS ECs0409 NC_002695.1 434970 435509 D similar to YAIL_ECOLI gi|1786550 (conserved in Escherichia coli K-12); nucleoprotein/polynucleotide-associated enzyme 434970..435509 Escherichia coli O157:H7 str. Sakai 914511 NP_308437.1 CDS ECs0410 NC_002695.1 435634 436467 R similar to YAIM_ECOLI gi|1786551 (conserved in Escherichia coli K-12); esterase complement(435634..436467) Escherichia coli O157:H7 str. Sakai 914512 NP_308438.1 CDS ECs0411 NC_002695.1 436560 437669 R similar to ADHC_ECOLI gi|1786552 (conserved in Escherichia coli K-12); alcohol dehydrogenase complement(436560..437669) Escherichia coli O157:H7 str. Sakai 914513 NP_308439.3 CDS ECs0412 NC_002695.1 437704 438000 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(437704..438000) Escherichia coli O157:H7 str. Sakai 914514 NP_308440.2 CDS fbpC NC_002695.1 438139 439185 R Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding protein complement(438139..439185) Escherichia coli O157:H7 str. Sakai 914515 NP_308441.1 CDS ECs0414 NC_002695.1 439197 441275 R similar to ferric transport system permeases e.g. AfuB [Actinobacillus pleuropneumoniae] gi|7387527|sp|Q44123|AFUB_ACTPL; ferric transport system permease complement(439197..441275) Escherichia coli O157:H7 str. Sakai 914516 NP_308442.1 CDS ECs0415 NC_002695.1 441344 442375 R similar to periplasmic-iron-binding proteins e.g. AfuA [Actinobacillus pleuropneumoniae] gi|1469286|gb|AAB05032.1; periplasmic-iron-binding protein complement(441344..442375) Escherichia coli O157:H7 str. Sakai 914517 NP_308443.1 CDS ECs0416 NC_002695.1 442372 443676 R similar to hexosephosphate transport system regulatory proteins e.g. UhpC [Escherichia coli K-12] gi|136770|sp|P09836|UHPC_ECOLI; regulatory protein complement(442372..443676) Escherichia coli O157:H7 str. Sakai 914518 NP_308444.1 CDS ECs0417 NC_002695.1 443761 445302 R similar to sensor protein kinases e.g. hexosephosphate transport system sensor protein UhpB [Escherichia coli K-12] gi|7429062|pir||RGECUB; sensor histidine protein kinase complement(443761..445302) Escherichia coli O157:H7 str. Sakai 914519 NP_308445.1 CDS ECs0418 NC_002695.1 445302 445931 R response regulator; similar to transcription regulators e.g. hexose phosphate transport system regulatory protein UhpA [Salmonella typhimurium] gi|136767|sp|P27667|UHPA_SALTY; transcriptional regulator complement(445302..445931) Escherichia coli O157:H7 str. Sakai 914520 NP_308446.1 CDS tauA NC_002695.1 446234 447196 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 446234..447196 Escherichia coli O157:H7 str. Sakai 914521 NP_308447.1 CDS tauB NC_002695.1 447209 447976 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding protein 447209..447976 Escherichia coli O157:H7 str. Sakai 914522 NP_308448.1 CDS ECs0421 NC_002695.1 447973 448800 D similar to TAUC_ECOLI gi|1786564 (conserved in Escherichia coli K-12); taurine transporter subunit 447973..448800 Escherichia coli O157:H7 str. Sakai 914523 NP_308449.1 CDS tauD NC_002695.1 448797 449648 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 448797..449648 Escherichia coli O157:H7 str. Sakai 914524 NP_308450.2 CDS ECs0423 NC_002695.1 449755 450729 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(449755..450729) Escherichia coli O157:H7 str. Sakai 914525 NP_308451.1 CDS ECs0424 NC_002695.1 451255 454197 D similar to YAIT_ECOLI gi|1786569 (conserved in Escherichia coli K-12); flagellin structural protein 451255..454197 Escherichia coli O157:H7 str. Sakai 914526 NP_308452.1 CDS ECs0425 NC_002695.1 454240 454908 D similar to YAIV_ECOLI gi|1786573 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 454240..454908 Escherichia coli O157:H7 str. Sakai 914527 NP_308453.1 CDS ECs0426 NC_002695.1 454909 456066 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(454909..456066) Escherichia coli O157:H7 str. Sakai 914528 NP_308454.1 CDS ECs0427 NC_002695.1 456418 457638 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 456418..457638 Escherichia coli O157:H7 str. Sakai 914529 NP_308455.1 CDS ECs0428 NC_002695.1 457651 458745 D similar to YAIW_ECOLI gi|1786576 (conserved in Escherichia coli K-12); hypothetical protein 457651..458745 Escherichia coli O157:H7 str. Sakai 914530 NP_308456.1 CDS ECs0429 NC_002695.1 458804 459112 R similar to B0379_ECOLI gi|1786577 (conserved in Escherichia coli K-12); hypothetical protein complement(458804..459112) Escherichia coli O157:H7 str. Sakai 914531 NP_308457.1 CDS ECs0430 NC_002695.1 459240 459584 D similar to B0380_ECOLI gi|1786578 (conserved in Escherichia coli K-12); hypothetical protein 459240..459584 Escherichia coli O157:H7 str. Sakai 914532 NP_308458.1 CDS ddl NC_002695.1 459608 460702 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(459608..460702) Escherichia coli O157:H7 str. Sakai 914533 NP_308459.1 CDS ECs0432 NC_002695.1 461165 461425 D similar to YAIB_ECOLI gi|1786581 (conserved in Escherichia coli K-12); hypothetical protein 461165..461425 Escherichia coli O157:H7 str. Sakai 914534 NP_308460.1 CDS ECs0433 NC_002695.1 461457 462941 D similar to PHOA_ECOLI gi|1786582 (conserved in Escherichia coli K-12); alkaline phosphatase 461457..462941 Escherichia coli O157:H7 str. Sakai 914535 NP_308461.1 CDS psiF NC_002695.1 463042 463380 D similar to PSIF_ECOLI gi|1786583 (conserved in Escherichia coli K-12); hypothetical protein 463042..463380 Escherichia coli O157:H7 str. Sakai 914536 NP_308462.1 CDS adrA NC_002695.1 463482 464597 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 463482..464597 Escherichia coli O157:H7 str. Sakai 914537 NP_308463.1 CDS proC NC_002695.1 464614 465423 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(464614..465423) Escherichia coli O157:H7 str. Sakai 914538 NP_308464.2 CDS ECs0436 NC_002695.1 465543 466001 D similar to YAII_ECOLI gi|1786586 (conserved in Escherichia coli K-12); hypothetical protein 465543..466001 Escherichia coli O157:H7 str. Sakai 914539 NP_308465.1 CDS aroL NC_002695.1 466184 466708 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 466184..466708 Escherichia coli O157:H7 str. Sakai 914540 NP_308466.1 CDS ECs0439 NC_002695.1 466758 466949 D similar to YAIA_ECOLI gi|1786588 (conserved in Escherichia coli K-12); hypothetical protein 466758..466949 Escherichia coli O157:H7 str. Sakai 914541 NP_308467.1 CDS ECs0440 NC_002695.1 467207 467884 D similar to AROM_ECOLI gi|1786589 (conserved in Escherichia coli K-12); hypothetical protein 467207..467884 Escherichia coli O157:H7 str. Sakai 914542 NP_308468.1 CDS ECs0441 NC_002695.1 467956 468240 D similar to YAIE_ECOLI gi|1786590 (conserved in Escherichia coli K-12); hypothetical protein 467956..468240 Escherichia coli O157:H7 str. Sakai 914543 NP_308469.1 CDS ECs0442 NC_002695.1 470382 470663 D similar to B0392_ECOLI gi|1786591 (conserved in Escherichia coli K-12); hypothetical protein 470382..470663 Escherichia coli O157:H7 str. Sakai 914544 NP_308470.1 CDS ECs0443 NC_002695.1 470660 471109 D hypothetical protein 470660..471109 Escherichia coli O157:H7 str. Sakai 914545 NP_308471.1 CDS rdgC NC_002695.1 471194 472105 R Required for efficient pilin antigenic variation; recombination associated protein complement(471194..472105) Escherichia coli O157:H7 str. Sakai 914546 NP_308472.2 CDS ECs0444 NC_002695.1 472230 473138 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 472230..473138 Escherichia coli O157:H7 str. Sakai 914547 NP_308473.2 CDS araJ NC_002695.1 473281 474549 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(473281..474549) Escherichia coli O157:H7 str. Sakai 914548 NP_308474.1 CDS ECs0447 NC_002695.1 474591 477734 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC complement(474591..477734) Escherichia coli O157:H7 str. Sakai 914549 NP_308475.1 CDS ECs0448 NC_002695.1 477731 478933 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD complement(477731..478933) Escherichia coli O157:H7 str. Sakai 914550 NP_308476.1 CDS ECs0449 NC_002695.1 479123 479812 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 479123..479812 Escherichia coli O157:H7 str. Sakai 914551 NP_308477.1 CDS phoR NC_002695.1 479870 481165 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 479870..481165 Escherichia coli O157:H7 str. Sakai 914552 NP_308478.1 CDS ECs0451 NC_002695.1 481572 482891 D similar to BRNQ_ECOLI gi|1786601 (conserved in Escherichia coli K-12); branched-chain amino acid ABC transporter substrate-binding protein 481572..482891 Escherichia coli O157:H7 str. Sakai 914553 NP_308479.1 CDS proY NC_002695.1 482967 484340 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; permease 482967..484340 Escherichia coli O157:H7 str. Sakai 914554 NP_308480.1 CDS ECs0453 NC_002695.1 484496 486313 D similar to MALZ_ECOLI gi|1786604 (conserved in Escherichia coli K-12); maltodextrin glucosidase 484496..486313 Escherichia coli O157:H7 str. Sakai 914555 NP_308481.1 CDS ECs0454 NC_002695.1 486501 487946 D hypothetical protein 486501..487946 Escherichia coli O157:H7 str. Sakai 914556 NP_308482.1 CDS ECs0455 NC_002695.1 487967 488548 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase complement(487967..488548) Escherichia coli O157:H7 str. Sakai 914557 NP_308483.1 CDS queA NC_002695.1 488641 489711 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 488641..489711 Escherichia coli O157:H7 str. Sakai 914558 NP_308484.1 CDS tgt NC_002695.1 489766 490893 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 489766..490893 Escherichia coli O157:H7 str. Sakai 914559 NP_308485.1 CDS yajC NC_002695.1 490916 491248 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 490916..491248 Escherichia coli O157:H7 str. Sakai 914560 NP_308486.1 CDS secD NC_002695.1 491276 493123 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 491276..493123 Escherichia coli O157:H7 str. Sakai 914561 NP_308487.1 CDS secF NC_002695.1 493134 494105 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 493134..494105 Escherichia coli O157:H7 str. Sakai 914562 NP_308488.1 CDS ECs0461 NC_002695.1 494256 494498 D similar to hypothetical protein [Yersinia enterocolitica] gi|3511032|gb|AAC33681.1; hypothetical protein 494256..494498 Escherichia coli O157:H7 str. Sakai 914563 NP_308489.1 CDS ECs0462 NC_002695.1 494491 494772 D similar to hypothetical protein [Yersinia pestis] gi|3822096|gb|AAC69816.1; hypothetical protein 494491..494772 Escherichia coli O157:H7 str. Sakai 914564 NP_308490.1 CDS ECs0463 NC_002695.1 494860 495207 D similar to YAJD_ECOLI gi|1786611 (conserved in Escherichia coli K-12); hypothetical protein 494860..495207 Escherichia coli O157:H7 str. Sakai 914565 NP_308491.1 CDS ECs0464 NC_002695.1 495384 496268 R similar to TSX_ECOLI gi|1786612 (conserved in Escherichia coli K-12); nucleoside-specific channel-forming protein Tsx complement(495384..496268) Escherichia coli O157:H7 str. Sakai 914566 NP_308492.2 CDS ECs0465 NC_002695.1 496567 497106 R similar to YAJI_ECOLI gi|1786613 (conserved in Escherichia coli K-12); hypothetical protein complement(496567..497106) Escherichia coli O157:H7 str. Sakai 914567 NP_308493.1 CDS nrdR NC_002695.1 497257 497706 D similar to YBAD_ECOLI gi|1786615 (conserved in Escherichia coli K-12); transcriptional regulator NrdR 497257..497706 Escherichia coli O157:H7 str. Sakai 914568 NP_308494.1 CDS ribD NC_002695.1 497710 498813 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 497710..498813 Escherichia coli O157:H7 str. Sakai 914569 NP_308495.1 CDS ribH NC_002695.1 498902 499372 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 498902..499372 Escherichia coli O157:H7 str. Sakai 914570 NP_308496.1 CDS nusB NC_002695.1 499392 499811 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 499392..499811 Escherichia coli O157:H7 str. Sakai 914571 NP_308497.1 CDS ECs0470 NC_002695.1 499889 500866 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 499889..500866 Escherichia coli O157:H7 str. Sakai 914572 NP_308498.1 CDS ECs0471 NC_002695.1 500844 501359 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 500844..501359 Escherichia coli O157:H7 str. Sakai 914573 NP_308499.1 CDS ECs0472 NC_002695.1 501537 503108 R hypothetical protein complement(501537..503108) Escherichia coli O157:H7 str. Sakai 914574 NP_308500.1 CDS ECs0473 NC_002695.1 503339 504313 R similar to YJAO_ECOLI gi|1786621 (conserved in Escherichia coli K-12); NAD(P)H-dependent xylose reductase complement(503339..504313) Escherichia coli O157:H7 str. Sakai 914575 NP_308501.1 CDS ECs0474 NC_002695.1 504368 506230 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(504368..506230) Escherichia coli O157:H7 str. Sakai 914576 NP_308502.1 CDS ECs0475 NC_002695.1 506255 507154 R similar to ISPA_ECOLI gi|1786623 (conserved in Escherichia coli K-12); geranyltranstransferase complement(506255..507154) Escherichia coli O157:H7 str. Sakai 914577 NP_308503.1 CDS ECs0476 NC_002695.1 507154 507396 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(507154..507396) Escherichia coli O157:H7 str. Sakai 914578 NP_308504.1 CDS ECs0477 NC_002695.1 507602 509050 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 507602..509050 Escherichia coli O157:H7 str. Sakai 914579 NP_308505.2 CDS ECs0478 NC_002695.1 509104 509694 R similar to THIJ_ECOLI gi|1786626 (conserved in Escherichia coli K-12); DJ-1 family protein complement(509104..509694) Escherichia coli O157:H7 str. Sakai 914580 NP_308506.1 CDS ECs0479 NC_002695.1 509657 510568 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(509657..510568) Escherichia coli O157:H7 str. Sakai 914581 NP_308507.2 CDS ECs0480 NC_002695.1 510736 511227 D nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 510736..511227 Escherichia coli O157:H7 str. Sakai 914582 NP_308508.2 CDS ECs0481 NC_002695.1 511355 512719 R similar to YAJR_ECOLI gi|1786630 (conserved in Escherichia coli K-12); transporter complement(511355..512719) Escherichia coli O157:H7 str. Sakai 914583 NP_308509.1 CDS ECs0482 NC_002695.1 512868 513758 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(512868..513758) Escherichia coli O157:H7 str. Sakai 914584 NP_308510.1 CDS ECs0483 NC_002695.1 513770 514099 R similar to CYOD_ECOLI gi|1786632 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit IV complement(513770..514099) Escherichia coli O157:H7 str. Sakai 914585 NP_308511.1 CDS ECs0484 NC_002695.1 514099 514713 R similar to CYOC_ECOLI gi|1786633 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit III complement(514099..514713) Escherichia coli O157:H7 str. Sakai 914586 NP_308512.1 CDS ECs0485 NC_002695.1 514703 516694 R similar to CYOB_ECOLI gi|1786634 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit I complement(514703..516694) Escherichia coli O157:H7 str. Sakai 914587 NP_308513.1 CDS ECs0486 NC_002695.1 516716 517663 R similar to CYOA_ECOLI gi|1786635 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit II complement(516716..517663) Escherichia coli O157:H7 str. Sakai 914588 NP_308514.1 CDS ampG NC_002695.1 518123 519598 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(518123..519598) Escherichia coli O157:H7 str. Sakai 914589 NP_308515.2 CDS ECs0488 NC_002695.1 519642 520220 R similar to YAJG_ECOLI gi|1786637 (conserved in Escherichia coli K-12); hypothetical protein complement(519642..520220) Escherichia coli O157:H7 str. Sakai 914590 NP_308516.2 CDS ECs0489 NC_002695.1 520525 520842 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 520525..520842 Escherichia coli O157:H7 str. Sakai 914591 NP_308517.1 CDS tig NC_002695.1 521186 522484 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 521186..522484 Escherichia coli O157:H7 str. Sakai 914592 NP_308518.1 CDS clpP NC_002695.1 522729 523352 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 522729..523352 Escherichia coli O157:H7 str. Sakai 914593 NP_308519.1 CDS clpX NC_002695.1 523478 524752 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding protein ClpX 523478..524752 Escherichia coli O157:H7 str. Sakai 914594 NP_308520.1 CDS ECs0493 NC_002695.1 524940 527294 D similar to LON_ECOLI gi|1786643 (conserved in Escherichia coli K-12); DNA-binding ATP-dependent protease La 524940..527294 Escherichia coli O157:H7 str. Sakai 914595 NP_308521.1 CDS ECs0494 NC_002695.1 527503 527775 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 527503..527775 Escherichia coli O157:H7 str. Sakai 914596 NP_308522.1 CDS ECs0495 NC_002695.1 527967 529838 D similar to YBAU_ECOLI gi|1786645 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase 527967..529838 Escherichia coli O157:H7 str. Sakai 914597 NP_308523.1 CDS ECs0496 NC_002695.1 529989 530360 D similar to YBAV_ECOLI gi|1786646 (conserved in Escherichia coli K-12); hypothetical protein 529989..530360 Escherichia coli O157:H7 str. Sakai 914598 NP_308524.1 CDS ECs0497 NC_002695.1 530466 530864 D similar to YBAW_ECOLI gi|1786647 (conserved in Escherichia coli K-12); hypothetical protein 530466..530864 Escherichia coli O157:H7 str. Sakai 914599 NP_308525.1 CDS ECs0498 NC_002695.1 530916 531611 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(530916..531611) Escherichia coli O157:H7 str. Sakai 914600 NP_308526.1 CDS ECs0499 NC_002695.1 531676 533376 R similar to YBAE_ECOLI gi|1786650 (conserved in Escherichia coli K-12); hypothetical protein complement(531676..533376) Escherichia coli O157:H7 str. Sakai 914601 NP_308527.1 CDS ECs0500 NC_002695.1 533464 534294 D similar to COF_ECOLI gi|1786651 (conserved in Escherichia coli K-12); hypothetical protein 533464..534294 Escherichia coli O157:H7 str. Sakai 914602 NP_308528.2 CDS ECs0501 NC_002695.1 534446 534904 D similar to YBAO_ECOLI gi|1786652 (conserved in Escherichia coli K-12); LRP-like transcriptional regulator 534446..534904 Escherichia coli O157:H7 str. Sakai 914603 NP_308529.1 CDS ECs0502 NC_002695.1 534934 536706 D similar to MDLA_ECOLI gi|1786653 (conserved in Escherichia coli K-12); multidrug transporter membrane\ATP-binding components 534934..536706 Escherichia coli O157:H7 str. Sakai 914604 NP_308530.1 CDS ECs0503 NC_002695.1 536699 538480 D similar to MDLB_ECOLI gi|1786654 (conserved in Escherichia coli K-12); multidrug transporter membrane\ATP-binding components 536699..538480 Escherichia coli O157:H7 str. Sakai 914605 NP_308531.1 CDS ECs0504 NC_002695.1 538661 538999 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 538661..538999 Escherichia coli O157:H7 str. Sakai 914607 NP_308532.1 CDS ECs0505 NC_002695.1 539029 540315 D similar to AMTB_ECOLI gi|1786656 (conserved in Escherichia coli K-12); ammonium transporter 539029..540315 Escherichia coli O157:H7 str. Sakai 914608 NP_308533.1 CDS ECs0506 NC_002695.1 540364 541224 R similar to TESB_ECOLI gi|1786657 (conserved in Escherichia coli K-12); acyl-CoA thioesterase complement(540364..541224) Escherichia coli O157:H7 str. Sakai 914609 NP_308534.2 CDS ECs0507 NC_002695.1 541457 542014 D similar to YBAY_ECOLI gi|1786658 (conserved in Escherichia coli K-12); glycoprotein/polysaccharide metabolism 541457..542014 Escherichia coli O157:H7 str. Sakai 914610 NP_308535.1 CDS ECs0508 NC_002695.1 542047 542436 R similar to YBAZ_ECOLI gi|1786659 (conserved in Escherichia coli K-12); hypothetical protein complement(542047..542436) Escherichia coli O157:H7 str. Sakai 914611 NP_308536.1 CDS ECs0509 NC_002695.1 542737 543090 D similar to YBAA_ECOLI gi|1786661 (conserved in Escherichia coli K-12); hypothetical protein 542737..543090 Escherichia coli O157:H7 str. Sakai 914613 NP_308537.1 CDS ECs0510 NC_002695.1 543132 544688 R similar to YLAB_ECOLI gi|1786662 (conserved in Escherichia coli K-12); hypothetical protein complement(543132..544688) Escherichia coli O157:H7 str. Sakai 914614 NP_308538.2 CDS ECs0511 NC_002695.1 544846 545316 R similar to YLAC_ECOLI gi|1786663 (conserved in Escherichia coli K-12); hypothetical protein complement(544846..545316) Escherichia coli O157:H7 str. Sakai 914615 NP_308539.1 CDS ECs0512 NC_002695.1 545432 545983 R similar to YLAD_ECOLI gi|1786664 (conserved in Escherichia coli K-12); maltose O-acetyltransferase complement(545432..545983) Escherichia coli O157:H7 str. Sakai 914616 NP_308540.1 CDS ECs0513 NC_002695.1 546155 546373 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(546155..546373) Escherichia coli O157:H7 str. Sakai 914617 NP_308541.1 CDS ECs0514 NC_002695.1 546399 546773 R similar to YBAJ_ECOLI gi|1786666 (conserved in Escherichia coli K-12); hypothetical protein complement(546399..546773) Escherichia coli O157:H7 str. Sakai 914618 NP_308542.1 CDS ECs0515 NC_002695.1 547319 550468 R similar to ACRB_ECOLI gi|1786667 (conserved in Escherichia coli K-12); acridine efflux pump complement(547319..550468) Escherichia coli O157:H7 str. Sakai 914619 NP_308543.1 CDS ECs0516 NC_002695.1 550491 551684 R similar to ACRA_ECOLI gi|1786668 (conserved in Escherichia coli K-12); acridine efflux pump complement(550491..551684) Escherichia coli O157:H7 str. Sakai 914620 NP_308544.1 CDS ECs0517 NC_002695.1 551826 552473 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; AcrR family transcriptional regulator 551826..552473 Escherichia coli O157:H7 str. Sakai 914621 NP_308545.1 CDS ECs0518 NC_002695.1 552601 555963 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 552601..555963 Escherichia coli O157:H7 str. Sakai 914622 NP_308546.1 CDS ECs0519 NC_002695.1 556002 556166 R similar to YBAM_ECOLI GI:1786672 (conserved in Escherichia coli K-12); hypothetical protein complement(556002..556166) Escherichia coli O157:H7 str. Sakai 914623 NP_308547.1 CDS ECs0520 NC_002695.1 556180 556707 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(556180..556707) Escherichia coli O157:H7 str. Sakai 914624 NP_308548.1 CDS ECs0521 NC_002695.1 556777 557154 D gene 58; similar to YBAN_ECOLI gi|1786674 (conserved in Escherichia coli K-12); hypothetical protein 556777..557154 Escherichia coli O157:H7 str. Sakai 914625 NP_308549.1 CDS ECs0522 NC_002695.1 557307 557858 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 557307..557858 Escherichia coli O157:H7 str. Sakai 914626 NP_308550.1 CDS ECs0523 NC_002695.1 557987 559918 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 557987..559918 Escherichia coli O157:H7 str. Sakai 914627 NP_308551.1 CDS ECs0524 NC_002695.1 559971 560300 D similar to YBAB_ECOLI gi|1786677 (conserved in Escherichia coli K-12); hypothetical protein 559971..560300 Escherichia coli O157:H7 str. Sakai 914628 NP_308552.1 CDS recR NC_002695.1 560300 560905 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 560300..560905 Escherichia coli O157:H7 str. Sakai 914629 NP_308553.1 CDS ECs0526 NC_002695.1 561015 562889 D molecular chaperone; heat shock protein 90 561015..562889 Escherichia coli O157:H7 str. Sakai 914630 NP_308554.1 CDS adk NC_002695.1 563070 563714 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 563070..563714 Escherichia coli O157:H7 str. Sakai 914631 NP_308555.1 CDS hemH NC_002695.1 563846 564808 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 563846..564808 Escherichia coli O157:H7 str. Sakai 914632 NP_308556.1 CDS ECs0529 NC_002695.1 564805 565764 R similar to YBAC_ECOLI gi|1786682 (conserved in Escherichia coli K-12); acetyl esterase complement(564805..565764) Escherichia coli O157:H7 str. Sakai 914633 NP_308557.1 CDS ECs0530 NC_002695.1 565916 567220 D similar to GSK_ECOLI gi|1786684 (conserved in Escherichia coli K-12); inosine-guanosine kinase 565916..567220 Escherichia coli O157:H7 str. Sakai 914634 NP_308558.1 CDS ECs0531 NC_002695.1 567353 569029 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein complement(567353..569029) Escherichia coli O157:H7 str. Sakai 914635 NP_308559.1 CDS ECs0532 NC_002695.1 569266 570486 R similar to FSR_ECOLI gi|1786686 (conserved in Escherichia coli K-12); fosmidomycin resistance protein complement(569266..570486) Escherichia coli O157:H7 str. Sakai 914636 NP_308560.1 CDS ushA NC_002695.1 570704 572356 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 570704..572356 Escherichia coli O157:H7 str. Sakai 914637 NP_308561.1 CDS ECs0534 NC_002695.1 572393 572872 R similar to YBAK_ECOLI gi|1786688 (conserved in Escherichia coli K-12); hypothetical protein complement(572393..572872) Escherichia coli O157:H7 str. Sakai 914638 NP_308562.1 CDS ECs0535 NC_002695.1 573076 573870 R similar to YBAP_ECOLI gi|1786689 (conserved in Escherichia coli K-12); ligase complement(573076..573870) Escherichia coli O157:H7 str. Sakai 914639 NP_308563.1 CDS ECs0536 NC_002695.1 573954 574349 D similar to YBAQ_ECOLI gi|1786690 (conserved in Escherichia coli K-12); hypothetical protein 573954..574349 Escherichia coli O157:H7 str. Sakai 914640 NP_308564.1 CDS copA NC_002695.1 574564 577068 R similar to COPA_ECOLI gi|2493016 (conserved in Escherichia coli K-12); copper exporting ATPase complement(574564..577068) Escherichia coli O157:H7 str. Sakai 914641 NP_308565.1 CDS ECs0538 NC_002695.1 577330 578262 D catalyzes the formation of glutamate from glutamine; glutaminase 577330..578262 Escherichia coli O157:H7 str. Sakai 914642 NP_308566.1 CDS ECs0539 NC_002695.1 578265 579557 D similar to YBAT_ECOLI gi|1786694 (conserved in Escherichia coli K-12); amino acid/amine transport protein 578265..579557 Escherichia coli O157:H7 str. Sakai 914643 NP_308567.1 CDS ECs0540 NC_002695.1 579895 581250 D similar to outer membrane transport proteins e.g. CyaE protein [Bordetella pertussis] gi|117799|sp|P11092|CYAE_BORPE; outer membrane transport protein 579895..581250 Escherichia coli O157:H7 str. Sakai 914644 NP_308568.1 CDS ECs0541 NC_002695.1 581353 585738 D similar to hypothetical protein [Synechocystis sp. strain PCC 6803] gi|7469433|pir||S76109; similar toRTX protein [Aeromonas salmonicida] gi|6752871|gb|AAF27914.1|AF218037_1; hypothetical protein 581353..585738 Escherichia coli O157:H7 str. Sakai 914888 NP_308569.1 CDS ECs0542 NC_002695.1 585946 601821 D similar to hypothetical protein [Synechocystis sp. strain PCC 6803] gi|7469433|pir||S76109; , similar to RTX protein [Aeromonas salmonicida] gi|6752871|gb|AAF27914.1|AF218037_1; hypothetical protein 585946..601821 Escherichia coli O157:H7 str. Sakai 914929 NP_308570.1 CDS ECs0543 NC_002695.1 601867 603987 D similar to transporters (ATP-binding proteins) e.g. LktB [Actinobacillus actinomycetemcomitans] gi|126357|sp|P23702|HLYB_ACTAC; ABC transporter ATP-binding protein 601867..603987 Escherichia coli O157:H7 str. Sakai 915052 NP_308571.1 CDS ECs0544 NC_002695.1 603984 605159 D similar to membrane fusion proteins e.g. [Sinorhizobium meliloti] gi|4689001|emb|CAB41456.1|; membrane fusion protein of a transport system 603984..605159 Escherichia coli O157:H7 str. Sakai 915176 NP_308572.1 CDS ECs0545 NC_002695.1 605156 605563 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 605156..605563 Escherichia coli O157:H7 str. Sakai 915192 NP_308573.1 CDS ECs0546 NC_002695.1 605767 606189 R lipoprotein complement(605767..606189) Escherichia coli O157:H7 str. Sakai 915251 NP_308575.1 CDS ECs0548 NC_002695.1 606274 607290 R similar to adhesin/invasin [Neisseria meningitidis MC58] gi|7227256|gb|AAF42321.1|, surface protein [Xylella fastidiosa] gi|9106565|gb|AAF84338.1|AE003982_11; adhesin complement(606274..607290) Escherichia coli O157:H7 str. Sakai 915314 NP_308576.1 CDS ECs0549 NC_002695.1 607657 608019 D hypothetical protein 607657..608019 Escherichia coli O157:H7 str. Sakai 915335 NP_308578.1 CDS ECs0551 NC_002695.1 608198 608653 R similar to YBBJ_ECOLI gi|1786696 (conserved in Escherichia coli K-12); hypothetical protein complement(608198..608653) Escherichia coli O157:H7 str. Sakai 915339 NP_308579.1 CDS ECs0552 NC_002695.1 608653 609570 R similar to YBBK_ECOLI gi|1786697 (conserved in Escherichia coli K-12); protease complement(608653..609570) Escherichia coli O157:H7 str. Sakai 915340 NP_308580.1 CDS ECs0553 NC_002695.1 609716 610393 D similar to YBBL_ECOLI gi|1786698 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 609716..610393 Escherichia coli O157:H7 str. Sakai 915342 NP_308581.2 CDS ECs0554 NC_002695.1 610380 611159 D similar to YBBM_ECOLI gi|1786699 (conserved in Escherichia coli K-12); metal resistance protein 610380..611159 Escherichia coli O157:H7 str. Sakai 915343 NP_308582.2 CDS ECs0555 NC_002695.1 611222 612076 R similar to YBBN_ECOLI gi|1786700 (conserved in Escherichia coli K-12); thioredoxin-like protein complement(611222..612076) Escherichia coli O157:H7 str. Sakai 915346 NP_308583.1 CDS ECs0556 NC_002695.1 612137 612946 R similar to YBBO_ECOLI gi|1786701 (conserved in Escherichia coli K-12); short chain dehydrogenase complement(612137..612946) Escherichia coli O157:H7 str. Sakai 915348 NP_308584.1 CDS ECs0558 NC_002695.1 612936 613562 R similar to TESA_ECOLI gi|1786702 (conserved in Escherichia coli K-12); multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 complement(612936..613562) Escherichia coli O157:H7 str. Sakai 915350 NP_308585.1 CDS ECs0557 NC_002695.1 613530 614216 D similar to YBBA_ECOLI gi|1786703 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 613530..614216 Escherichia coli O157:H7 str. Sakai 915351 NP_308586.1 CDS ECs0559 NC_002695.1 614213 616627 D similar to YBBP_ECOLI gi|1786704 (conserved in Escherichia coli K-12); oxidoreductase 614213..616627 Escherichia coli O157:H7 str. Sakai 915353 NP_308587.1 CDS ECs0560 NC_002695.1 617057 621253 D core protein with extension; similar to RHSD_ECOLI gi|1786706; similar to B0499_ECOLI gi|1786708; Rhs protein; protein RhsD 617057..621253 Escherichia coli O157:H7 str. Sakai 915354 NP_308588.1 CDS ECs0561 NC_002695.1 621234 621494 D similar to YBBD_ECOLI gi|1786709 (conserved in Escherichia coli K-12); hypothetical protein 621234..621494 Escherichia coli O157:H7 str. Sakai 915355 NP_308590.2 CDS ECs0563 NC_002695.1 622238 622609 R similar to B0502_ECOLI gi|1786711 (conserved in Escherichia coli K-12); hypothetical protein complement(622238..622609) Escherichia coli O157:H7 str. Sakai 915360 NP_308591.1 CDS ECs0564 NC_002695.1 622725 623819 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(622725..623819) Escherichia coli O157:H7 str. Sakai 915481 NP_308592.1 CDS ECs0565 NC_002695.1 623888 624814 R activator of the allDC-ylbA operon involved in allantoin utilization; AllS family transcriptional regulator complement(623888..624814) Escherichia coli O157:H7 str. Sakai 915486 NP_308593.1 CDS ECs0566 NC_002695.1 625044 625526 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 625044..625526 Escherichia coli O157:H7 str. Sakai 915530 NP_308594.1 CDS ECs0567 NC_002695.1 625604 626419 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 625604..626419 Escherichia coli O157:H7 str. Sakai 915706 NP_308595.1 CDS ECs0568 NC_002695.1 626509 628290 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 626509..628290 Escherichia coli O157:H7 str. Sakai 915770 NP_308596.1 CDS ECs0569 NC_002695.1 628303 629079 D similar to HYI_ECOLI gi|232160 (conserved in Escherichia coli K-12); hydroxypyruvate isomerase 628303..629079 Escherichia coli O157:H7 str. Sakai 915783 NP_308597.1 CDS ECs0570 NC_002695.1 629180 630058 D similar to GLXR_ECOLI gi|2494062 (conserved in Escherichia coli K-12); tartronic semialdehyde reductase 629180..630058 Escherichia coli O157:H7 str. Sakai 915794 NP_308598.1 CDS ECs0571 NC_002695.1 630090 630368 D similar to YBBV_ECOLI gi|1786720 (conserved in Escherichia coli K-12); hypothetical protein 630090..630368 Escherichia coli O157:H7 str. Sakai 915825 NP_308599.1 CDS ECs0572 NC_002695.1 630227 631618 D similar to YBBW_ECOLI gi|1786721 (conserved in Escherichia coli K-12); allantoin permease 630227..631618 Escherichia coli O157:H7 str. Sakai 915888 NP_308602.2 CDS ECs0575 NC_002695.1 633073 634374 D similar to YBBY_ECOLI gi|1786723 (conserved in Escherichia coli K-12); purine permease YbbY 633073..634374 Escherichia coli O157:H7 str. Sakai 916089 NP_308603.1 CDS ECs0576 NC_002695.1 634396 635541 D similar to GLXK_ECOLI gi|2495546 (conserved in Escherichia coli K-12); glycerate kinase 634396..635541 Escherichia coli O157:H7 str. Sakai 916187 NP_308604.1 CDS ECs0577 NC_002695.1 635769 636554 R similar to YLBA_ECOLI gi|1786725 (conserved in Escherichia coli K-12); hypothetical protein complement(635769..636554) Escherichia coli O157:H7 str. Sakai 916390 NP_308605.1 CDS ECs0578 NC_002695.1 636565 637800 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(636565..637800) Escherichia coli O157:H7 str. Sakai 916571 NP_308606.1 CDS ECs0579 NC_002695.1 637822 638871 R similar to ALLD_ECOLI gi|2497861 (conserved in Escherichia coli K-12); ureidoglycolate dehydrogenase complement(637822..638871) Escherichia coli O157:H7 str. Sakai 916572 NP_308607.1 CDS ECs0580 NC_002695.1 639188 640855 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 639188..640855 Escherichia coli O157:H7 str. Sakai 916573 NP_308608.1 CDS ECs0581 NC_002695.1 641123 642124 D similar to YLBE_ECOLI gi|1786730 (conserved in Escherichia coli K-12); hypothetical protein 641123..642124 Escherichia coli O157:H7 str. Sakai 916600 NP_308609.1 CDS ECs0582 NC_002695.1 642135 642950 D similar to YLBF_ECOLI gi|1786731 (conserved in Escherichia coli K-12); carboxylase 642135..642950 Escherichia coli O157:H7 str. Sakai 916659 NP_308610.1 CDS ECs0583 NC_002695.1 642947 643840 D forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 642947..643840 Escherichia coli O157:H7 str. Sakai 916781 NP_308611.1 CDS ECs0584 NC_002695.1 643979 645046 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(643979..645046) Escherichia coli O157:H7 str. Sakai 916809 NP_308612.1 CDS ECs0585 NC_002695.1 645043 645552 R Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(645043..645552) Escherichia coli O157:H7 str. Sakai 916940 NP_308613.1 CDS ECs0586 NC_002695.1 645670 646392 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(645670..646392) Escherichia coli O157:H7 str. Sakai 916941 NP_308614.1 CDS ECs0587 NC_002695.1 646395 646889 R similar to PPIB_ECOLI gi|1786736 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase B complement(646395..646889) Escherichia coli O157:H7 str. Sakai 916942 NP_308615.1 CDS cysS NC_002695.1 647063 648448 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 647063..648448 Escherichia coli O157:H7 str. Sakai 916943 NP_308616.1 CDS ECs0589 NC_002695.1 648484 649005 R similar to YBCI_ECOLI gi|1786738 (conserved in Escherichia coli K-12); hypothetical protein complement(648484..649005) Escherichia coli O157:H7 str. Sakai 916944 NP_308617.2 CDS ECs0590 NC_002695.1 649113 649325 R similar to YBCJ_ECOLI gi|1786740 (conserved in Escherichia coli K-12); hypothetical protein complement(649113..649325) Escherichia coli O157:H7 str. Sakai 916945 NP_308618.1 CDS ECs0591 NC_002695.1 649327 650193 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(649327..650193) Escherichia coli O157:H7 str. Sakai 916946 NP_308619.2 CDS ECs0592 NC_002695.1 650664 651206 D similar to SFMA_ECOLI gi|1786742 (conserved in Escherichia coli K-12); fimbrial-like protein 650664..651206 Escherichia coli O157:H7 str. Sakai 916947 NP_308620.1 CDS ECs0593 NC_002695.1 651426 652118 D similar to SFMC_ECOLI gi|1786743 (conserved in Escherichia coli K-12); chaperone 651426..652118 Escherichia coli O157:H7 str. Sakai 916948 NP_308621.1 CDS ECs0594 NC_002695.1 652149 654758 D similar to SFMD_ECOLI gi|1786744 (conserved in Escherichia coli K-12); outer membrane protein 652149..654758 Escherichia coli O157:H7 str. Sakai 916950 NP_308622.1 CDS ECs0595 NC_002695.1 654801 655778 D similar to SFMH_ECOLI gi|1786745 (conserved in Escherichia coli K-12); protein SfmH 654801..655778 Escherichia coli O157:H7 str. Sakai 916951 NP_308623.1 CDS ECs0596 NC_002695.1 655789 656304 D similar to SFMF_ECOLI gi|1786746 (conserved in Escherichia coli K-12); fimbrial protein 655789..656304 Escherichia coli O157:H7 str. Sakai 916953 NP_308624.1 CDS ECs0597 NC_002695.1 656307 656939 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(656307..656939) Escherichia coli O157:H7 str. Sakai 916954 NP_308625.1 CDS ECs0598 NC_002695.1 657304 658065 R similar to ENVY_ECOLI gi|1786778 (conserved in Escherichia coli K-12); envelope protein; EnvY complement(657304..658065) Escherichia coli O157:H7 str. Sakai 916956 NP_308626.1 CDS ECs0599 NC_002695.1 658248 659138 R similar to YBCH_ECOLI gi|1786779 (conserved in Escherichia coli K-12); hypothetical protein complement(658248..659138) Escherichia coli O157:H7 str. Sakai 916957 NP_308627.1 CDS ECs0600 NC_002695.1 659139 662111 R similar to NFRA_ECOLI gi|1786780 (conserved in Escherichia coli K-12); bacteriophage N4 receptor, outer membrane subunit complement(659139..662111) Escherichia coli O157:H7 str. Sakai 916958 NP_308628.1 CDS nfrB NC_002695.1 662098 664335 R similar to NFRB_ECOLI gi|1786781 (conserved in Escherichia coli K-12); bacteriophage N4 adsorption protein B complement(662098..664335) Escherichia coli O157:H7 str. Sakai 916959 NP_308629.1 CDS ECs0602 NC_002695.1 664601 665737 R similar to H repeat-associated protein in RhsB element [Escherichia coli] gi|140772|sp|P28912|YHHI_ECOLI; H repeat-containing protein complement(664601..665737) Escherichia coli O157:H7 str. Sakai 916960 NP_944506.1 CDS ECs5380 NC_002695.1 665952 666173 R hypothetical protein complement(665952..666173) Escherichia coli O157:H7 str. Sakai 2693790 NP_308630.1 CDS ECs0603 NC_002695.1 666200 667534 R Rhs protein; similar to Rhs protein - Streptomyces coelicolor A3(2) gi|7321289|emb|CAB82067.1; similar toRhsE protein - E. coli gi|2507113|sp|P24211|; Rhs core protein complement(666200..667534) Escherichia coli O157:H7 str. Sakai 916961 NP_308631.1 CDS ECs0604 NC_002695.1 667703 668110 R hypothetical protein complement(667703..668110) Escherichia coli O157:H7 str. Sakai 916962 NP_308632.1 CDS ECs0605 NC_002695.1 668128 672978 R Rhs protein; similar to Rhs protein [Streptomyces coelicolor A3(2)] gi|7321289|emb|CAB82067.1; similar toRhsH protein [Escherichia coli strain ec45] gi|2920634|gb|AAC32471.1; Rhs core protein with extension complement(668128..672978) Escherichia coli O157:H7 str. Sakai 916963 NP_308633.1 CDS ECs0606 NC_002695.1 672998 673459 R hypothetical protein complement(672998..673459) Escherichia coli O157:H7 str. Sakai 916964 NP_308634.1 CDS ECs0607 NC_002695.1 673487 675388 R similar to Vgr proteins e.g. [Escherichia coli strain ec11] gi|2920640|gb|AAC32475.1; hypothetical protein complement(673487..675388) Escherichia coli O157:H7 str. Sakai 916965 NP_308635.1 CDS ECs0608 NC_002695.1 675982 677430 R similar to YBCZ_ECOLI gi|1786783 (conserved in Escherichia coli K-12); sensor kinase CusS complement(675982..677430) Escherichia coli O157:H7 str. Sakai 916966 NP_308636.1 CDS ECs0609 NC_002695.1 677420 678103 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; CusR family transcriptional regulator complement(677420..678103) Escherichia coli O157:H7 str. Sakai 916967 NP_308637.1 CDS ECs0610 NC_002695.1 678260 679642 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 678260..679642 Escherichia coli O157:H7 str. Sakai 916968 NP_308638.1 CDS ECs0611 NC_002695.1 679666 679998 D similar to YLCC_ECOLI gi|1786786 (conserved in Escherichia coli K-12); copper-binding protein 679666..679998 Escherichia coli O157:H7 str. Sakai 916969 NP_308639.1 CDS ECs0612 NC_002695.1 680014 681237 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 680014..681237 Escherichia coli O157:H7 str. Sakai 916970 NP_308640.1 CDS ECs0613 NC_002695.1 681249 684386 D similar to YBDE_ECOLI gi|1786788 (conserved in Escherichia coli K-12); inner membrane component for iron transport 681249..684386 Escherichia coli O157:H7 str. Sakai 916972 NP_308641.1 CDS ECs0614 NC_002695.1 684488 685864 D similar to PHEP_ECOLI gi|1786789 (conserved in Escherichia coli K-12); phenylalanine transporter 684488..685864 Escherichia coli O157:H7 str. Sakai 916973 NP_308642.1 CDS ECs0615 NC_002695.1 685932 687179 R similar to YBDG_ECOLI gi|1786791 (conserved in Escherichia coli K-12); transport complement(685932..687179) Escherichia coli O157:H7 str. Sakai 916974 NP_308643.1 CDS ECs0616 NC_002695.1 687287 687940 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(687287..687940) Escherichia coli O157:H7 str. Sakai 916975 NP_308644.1 CDS ECs0617 NC_002695.1 688034 688402 R similar to YBDF_ECOLI gi|1786793 (conserved in Escherichia coli K-12); hypothetical protein complement(688034..688402) Escherichia coli O157:H7 str. Sakai 916976 NP_308645.1 CDS ECs0618 NC_002695.1 688467 688715 R similar to YBDJ_ECOLI gi|1786794 (conserved in Escherichia coli K-12); hypothetical protein complement(688467..688715) Escherichia coli O157:H7 str. Sakai 916977 NP_308646.1 CDS ECs0619 NC_002695.1 688781 689899 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(688781..689899) Escherichia coli O157:H7 str. Sakai 916978 NP_308647.1 CDS ECs0620 NC_002695.1 690338 690490 D similar to YBDY_ECOLI gi|3025009|sp|P77091 (conserved in Escherichia coli K-12); hypothetical protein 690338..690490 Escherichia coli O157:H7 str. Sakai 916979 NP_308648.1 CDS ECs0621 NC_002695.1 690742 690993 D similar to hypothetical protein in cspA-glyS intergenic region [Escherichia coli] gi|3025009|sp|P77091; hypothetical protein 690742..690993 Escherichia coli O157:H7 str. Sakai 916980 NP_308649.1 CDS ECs0622 NC_002695.1 691115 691744 R similar to ENTD_ECOLI gi|1786797 (conserved in Escherichia coli K-12); phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(691115..691744) Escherichia coli O157:H7 str. Sakai 916981 NP_308650.1 CDS ECs0623 NC_002695.1 691910 694150 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(691910..694150) Escherichia coli O157:H7 str. Sakai 916982 NP_308651.1 CDS ECs0624 NC_002695.1 694471 695595 D similar to FES_ECOLI gi|1786799 (conserved in Escherichia coli K-12); enterobactin/ferric enterobactin esterase 694471..695595 Escherichia coli O157:H7 str. Sakai 916983 NP_944507.1 CDS ECs5381 NC_002695.1 695598 695816 D hypothetical protein 695598..695816 Escherichia coli O157:H7 str. Sakai 2693791 NP_308652.1 CDS entF NC_002695.1 695813 699694 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 695813..699694 Escherichia coli O157:H7 str. Sakai 916984 NP_308653.1 CDS ECs0626 NC_002695.1 699910 701043 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 699910..701043 Escherichia coli O157:H7 str. Sakai 916985 NP_308654.1 CDS ECs0627 NC_002695.1 701040 701855 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(701040..701855) Escherichia coli O157:H7 str. Sakai 916986 NP_308655.1 CDS ECs0628 NC_002695.1 701852 702844 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(701852..702844) Escherichia coli O157:H7 str. Sakai 916987 NP_308656.1 CDS ECs0629 NC_002695.1 702841 703845 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(702841..703845) Escherichia coli O157:H7 str. Sakai 916988 NP_308657.1 CDS ECs0630 NC_002695.1 703956 705206 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 703956..705206 Escherichia coli O157:H7 str. Sakai 916989 NP_308658.1 CDS ECs0631 NC_002695.1 705210 706166 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(705210..706166) Escherichia coli O157:H7 str. Sakai 916990 NP_308659.1 CDS ECs0632 NC_002695.1 706355 707530 D synthesizes isochorismate acid from chorismate; isochorismate synthase 706355..707530 Escherichia coli O157:H7 str. Sakai 916991 NP_308660.1 CDS entE NC_002695.1 707540 709150 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 707540..709150 Escherichia coli O157:H7 str. Sakai 916992 NP_308661.1 CDS ECs0634 NC_002695.1 709164 710021 D similar to ENTB_ECOLI gi|1786811 (conserved in Escherichia coli K-12); 2,3-dihydro-2,3-dihydroxybenzoate synthetase 709164..710021 Escherichia coli O157:H7 str. Sakai 916993 NP_308662.1 CDS ECs0635 NC_002695.1 710021 710767 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 710021..710767 Escherichia coli O157:H7 str. Sakai 916994 NP_308663.1 CDS ECs0636 NC_002695.1 710770 711183 D similar to YBDB_ECOLI gi|1786813 (conserved in Escherichia coli K-12); hypothetical protein 710770..711183 Escherichia coli O157:H7 str. Sakai 916995 NP_308664.1 CDS ECs0637 NC_002695.1 711364 713469 D similar to CSTA_ECOLI gi|1786814 (conserved in Escherichia coli K-12); carbon starvation protein 711364..713469 Escherichia coli O157:H7 str. Sakai 916996 NP_944508.1 CDS ECs5382 NC_002695.1 713651 713848 D hypothetical protein 713651..713848 Escherichia coli O157:H7 str. Sakai 2693792 NP_308665.1 CDS ECs0638 NC_002695.1 713858 714946 R member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein complement(713858..714946) Escherichia coli O157:H7 str. Sakai 916997 NP_308666.1 CDS ECs0639 NC_002695.1 715055 716215 D catalyzes the transfer of an amino moiety; aminotransferase 715055..716215 Escherichia coli O157:H7 str. Sakai 916998 NP_308667.1 CDS ECs0640 NC_002695.1 716216 716845 R similar to YBDM_ECOLI gi|1786817 (conserved in Escherichia coli K-12); hypothetical protein complement(716216..716845) Escherichia coli O157:H7 str. Sakai 916999 NP_308668.1 CDS ECs0641 NC_002695.1 716818 718038 R similar to YBDN_ECOLI gi|1786818 (conserved in Escherichia coli K-12); hypothetical protein complement(716818..718038) Escherichia coli O157:H7 str. Sakai 917000 NP_308669.1 CDS ECs0642 NC_002695.1 718185 719087 R similar to YBDO_ECOLI gi|1786820 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(718185..719087) Escherichia coli O157:H7 str. Sakai 917001 NP_308670.3 CDS dsbG NC_002695.1 719297 720043 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(719297..720043) Escherichia coli O157:H7 str. Sakai 917002 NP_308671.1 CDS ECs0644 NC_002695.1 720415 720978 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 720415..720978 Escherichia coli O157:H7 str. Sakai 917003 NP_308672.1 CDS ECs0645 NC_002695.1 721077 722672 D similar to AHPF_ECOLI gi|1786823 (conserved in Escherichia coli K-12); alkyl hydroperoxide reductase 721077..722672 Escherichia coli O157:H7 str. Sakai 917004 NP_308673.1 CDS ECs0646 NC_002695.1 722793 723221 R similar to YBDQ_ECOLI gi|1786824 (conserved in Escherichia coli K-12); hypothetical protein complement(722793..723221) Escherichia coli O157:H7 str. Sakai 917005 NP_308674.1 CDS ECs0647 NC_002695.1 723442 724680 D similar to YBDR_ECOLI gi|1786825 (conserved in Escherichia coli K-12); oxidoreductase 723442..724680 Escherichia coli O157:H7 str. Sakai 917006 NP_944509.1 CDS ECs5383 NC_002695.1 724684 724872 R hypothetical protein complement(724684..724872) Escherichia coli O157:H7 str. Sakai 2693760 NP_308675.1 CDS ECs0648 NC_002695.1 724761 725222 D similar to B0609_ECOLI gi|1786826 (conserved in Escherichia coli K-12); hypothetical protein 724761..725222 Escherichia coli O157:H7 str. Sakai 917007 NP_308676.1 CDS ECs0649 NC_002695.1 724911 725321 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(724911..725321) Escherichia coli O157:H7 str. Sakai 917008 NP_308677.1 CDS ECs0650 NC_002695.1 725551 726357 R similar to RNA_ECOLI gi|1786828 (conserved in Escherichia coli K-12); ribonuclease I complement(725551..726357) Escherichia coli O157:H7 str. Sakai 917009 NP_308678.1 CDS ECs0651 NC_002695.1 726471 727934 R similar to YBDS_ECOLI gi|1786829 (conserved in Escherichia coli K-12); hypothetical protein complement(726471..727934) Escherichia coli O157:H7 str. Sakai 917010 NP_308679.1 CDS citG NC_002695.1 727985 728863 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(727985..728863) Escherichia coli O157:H7 str. Sakai 917011 NP_308680.1 CDS citX NC_002695.1 728838 729389 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase complement(728838..729389) Escherichia coli O157:H7 str. Sakai 917013 NP_308681.1 CDS ECs0654 NC_002695.1 729393 730925 R similar to CITF_ECOLI gi|1786832 (conserved in Escherichia coli K-12); citrate lyase subunit alpha complement(729393..730925) Escherichia coli O157:H7 str. Sakai 917014 NP_308682.2 CDS ECs0655 NC_002695.1 730936 731844 R similar to CITE_ECOLI gi|1786833 (conserved in Escherichia coli K-12); citrate lyase subunit beta complement(730936..731844) Escherichia coli O157:H7 str. Sakai 917015 NP_308683.1 CDS ECs0656 NC_002695.1 731841 732137 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(731841..732137) Escherichia coli O157:H7 str. Sakai 917016 NP_308684.2 CDS ECs0657 NC_002695.1 732152 733210 R similar to CITC_ECOLI gi|1786835 (conserved in Escherichia coli K-12); citrate lyase synthetase complement(732152..733210) Escherichia coli O157:H7 str. Sakai 917017 NP_308685.1 CDS ECs0658 NC_002695.1 733590 735248 D similar to CITA_ECOLI gi|1786837 (conserved in Escherichia coli K-12); sensor-type protein 733590..735248 Escherichia coli O157:H7 str. Sakai 917018 NP_308686.1 CDS dpiA NC_002695.1 735217 735897 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 735217..735897 Escherichia coli O157:H7 str. Sakai 917019 NP_308687.1 CDS dcuC NC_002695.1 735938 737323 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(735938..737323) Escherichia coli O157:H7 str. Sakai 917020 NP_308688.1 CDS pagP NC_002695.1 737912 738472 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 737912..738472 Escherichia coli O157:H7 str. Sakai 917021 NP_308689.1 CDS cspE NC_002695.1 738647 738856 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 738647..738856 Escherichia coli O157:H7 str. Sakai 917022 NP_308690.1 CDS ccrB NC_002695.1 738910 739293 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(738910..739293) Escherichia coli O157:H7 str. Sakai 917023 NP_308691.1 CDS ECs0664 NC_002695.1 739386 740174 D similar to YBEH_ECOLI gi|1786843, YBEM_ECOLI, gi|1786844; amidase 739386..740174 Escherichia coli O157:H7 str. Sakai 917024 NP_308692.1 CDS tatE NC_002695.1 740303 740506 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 740303..740506 Escherichia coli O157:H7 str. Sakai 917025 NP_308693.1 CDS ECs0666 NC_002695.1 740607 741572 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(740607..741572) Escherichia coli O157:H7 str. Sakai 917026 NP_308694.2 CDS ECs0667 NC_002695.1 741781 742734 R similar to YBEF_ECOLI gi|1786847 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator complement(741781..742734) Escherichia coli O157:H7 str. Sakai 917027 NP_308695.2 CDS lipB NC_002695.1 742994 743635 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(742994..743635) Escherichia coli O157:H7 str. Sakai 917028 NP_308696.1 CDS ECs0669 NC_002695.1 743736 743999 R similar to YBED_ECOLI gi|1786850 (conserved in Escherichia coli K-12); hypothetical protein complement(743736..743999) Escherichia coli O157:H7 str. Sakai 917029 NP_308697.1 CDS ECs0670 NC_002695.1 744109 745320 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase complement(744109..745320) Escherichia coli O157:H7 str. Sakai 917030 NP_308698.1 CDS ECs0671 NC_002695.1 745460 746548 R similar to RLPA_ECOLI gi|1786852 (conserved in Escherichia coli K-12); rare lipoprotein A complement(745460..746548) Escherichia coli O157:H7 str. Sakai 917032 NP_308699.1 CDS ECs0672 NC_002695.1 746559 747671 R similar to MRDB_ECOLI gi|1786853 (conserved in Escherichia coli K-12); cell wall shape-determining protein complement(746559..747671) Escherichia coli O157:H7 str. Sakai 917033 NP_308700.1 CDS ECs0673 NC_002695.1 747674 749575 R similar to MRDA_ECOLI gi|1786854 (conserved in Escherichia coli K-12); penicillin-binding protein 2 complement(747674..749575) Escherichia coli O157:H7 str. Sakai 917034 NP_308701.1 CDS ECs0674 NC_002695.1 749606 750073 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(749606..750073) Escherichia coli O157:H7 str. Sakai 917035 NP_308702.2 CDS ECs0675 NC_002695.1 750077 750394 R similar to YBEB_ECOLI gi|1786856 (conserved in Escherichia coli K-12); hypothetical protein complement(750077..750394) Escherichia coli O157:H7 str. Sakai 917036 NP_308703.1 CDS ECs0676 NC_002695.1 750654 751265 R similar to PHPB_ECOLI gi|1786857 (conserved in Escherichia coli K-12); phosphohistidine protein; PhpB complement(750654..751265) Escherichia coli O157:H7 str. Sakai 917037 NP_308704.1 CDS nadD NC_002695.1 751289 751930 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(751289..751930) Escherichia coli O157:H7 str. Sakai 917038 NP_308705.1 CDS holA NC_002695.1 751932 752963 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(751932..752963) Escherichia coli O157:H7 str. Sakai 917039 NP_308706.1 CDS ECs0679 NC_002695.1 752963 753544 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(752963..753544) Escherichia coli O157:H7 str. Sakai 917040 NP_308707.1 CDS leuS NC_002695.1 753559 756141 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(753559..756141) Escherichia coli O157:H7 str. Sakai 917041 NP_308708.1 CDS ECs0681 NC_002695.1 756377 756859 D similar to YBEL_ECOLI gi|1786863 (conserved in Escherichia coli K-12); hypothetical protein 756377..756859 Escherichia coli O157:H7 str. Sakai 917042 NP_308709.1 CDS ECs0682 NC_002695.1 756929 757516 R similar to YBEQ_ECOLI gi|1786864; hypothetical protein complement(756929..757516) Escherichia coli O157:H7 str. Sakai 917043 NP_308710.1 CDS ECs0683 NC_002695.1 758071 758778 D similar to YBER_ECOLI gi|1786865 (conserved in Escherichia coli K-12); hypothetical protein 758071..758778 Escherichia coli O157:H7 str. Sakai 917044 NP_308711.1 CDS ECs0684 NC_002695.1 758775 760202 D similar to YBES_ECOLI gi|1786866 (conserved in Escherichia coli K-12); hypothetical protein 758775..760202 Escherichia coli O157:H7 str. Sakai 917045 NP_308712.1 CDS ECs0685 NC_002695.1 760212 760766 R similar to YBET_ECOLI gi|1786867 (conserved in Escherichia coli K-12); hypothetical protein complement(760212..760766) Escherichia coli O157:H7 str. Sakai 917046 NP_308713.1 CDS ECs0686 NC_002695.1 760868 761575 D similar to YBEU_ECOLI gi|1786868 (conserved in Escherichia coli K-12); tRNA ligase 760868..761575 Escherichia coli O157:H7 str. Sakai 917047 NP_308716.1 CDS ECs0689 NC_002695.1 763083 764753 R similar to YBEW_ECOLI gi|1786870 (conserved in Escherichia coli K-12); molecular chaperone DnaK complement(763083..764753) Escherichia coli O157:H7 str. Sakai 917050 NP_308717.1 CDS rihA NC_002695.1 764837 765772 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(764837..765772) Escherichia coli O157:H7 str. Sakai 917051 NP_308718.1 CDS ECs0691 NC_002695.1 765890 766615 R similar to GLTL_ECOLI gi|1786872 (conserved in Escherichia coli K-12); glutamate/aspartate ABC transporter ATP-binding protein complement(765890..766615) Escherichia coli O157:H7 str. Sakai 917052 NP_308719.1 CDS ECs0692 NC_002695.1 766615 767289 R similar to GLTK_ECOLI gi|1786873 (conserved in Escherichia coli K-12); glutamate/aspartate transport system permease complement(766615..767289) Escherichia coli O157:H7 str. Sakai 917053 NP_308720.1 CDS ECs0693 NC_002695.1 767289 768029 R similar to GLTJ_ECOLI gi|1786874 (conserved in Escherichia coli K-12); glutamate/aspartate transport system permease complement(767289..768029) Escherichia coli O157:H7 str. Sakai 917054 NP_308721.1 CDS ECs0694 NC_002695.1 768199 769107 R similar to YBEJ_ECOLI gi|1786876 (conserved in Escherichia coli K-12); glutamate and aspartate transporter subunit complement(768199..769107) Escherichia coli O157:H7 str. Sakai 917055 NP_308722.1 CDS lnt NC_002695.1 769504 771042 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(769504..771042) Escherichia coli O157:H7 str. Sakai 917056 NP_308723.1 CDS ECs0696 NC_002695.1 771067 771945 R similar to YBEX_ECOLI gi|1786879 (conserved in Escherichia coli K-12); transporter complement(771067..771945) Escherichia coli O157:H7 str. Sakai 917057 NP_308724.1 CDS ECs0697 NC_002695.1 772035 772502 R similar to YBEY_ECOLI gi|1786880 (conserved in Escherichia coli K-12); metalloprotease complement(772035..772502) Escherichia coli O157:H7 str. Sakai 917058 NP_308725.1 CDS ECs0698 NC_002695.1 772499 773578 R similar to YBEZ_ECOLI gi|1786881 (conserved in Escherichia coli K-12); ATP-binding protein in pho regulon complement(772499..773578) Escherichia coli O157:H7 str. Sakai 917059 NP_308726.1 CDS ECs0699 NC_002695.1 773692 775116 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(773692..775116) Escherichia coli O157:H7 str. Sakai 917060 NP_308727.1 CDS ubiF NC_002695.1 775262 776437 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 775262..776437 Escherichia coli O157:H7 str. Sakai 917062 NP_308731.1 CDS asnB NC_002695.1 777676 779340 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(777676..779340) Escherichia coli O157:H7 str. Sakai 917073 NP_308732.1 CDS ECs0705 NC_002695.1 779597 780349 R similar to NAGD_ECOLI gi|1786890 (conserved in Escherichia coli K-12); UMP phosphatase complement(779597..780349) Escherichia coli O157:H7 str. Sakai 917074 NP_308733.1 CDS ECs0706 NC_002695.1 780397 781617 R nag repressor; similar to NAGC_ECOLI gi|1786891 (conserved in Escherichia coli K-12); transcriptional repressor of N-acetylglucosamine operon complement(780397..781617) Escherichia coli O157:H7 str. Sakai 917075 NP_308734.1 CDS nagA NC_002695.1 781626 782774 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(781626..782774) Escherichia coli O157:H7 str. Sakai 917076 NP_308735.1 CDS nagB NC_002695.1 782834 783634 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(782834..783634) Escherichia coli O157:H7 str. Sakai 917077 NP_308736.1 CDS ECs0709 NC_002695.1 783967 785913 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 783967..785913 Escherichia coli O157:H7 str. Sakai 917078 NP_308737.1 CDS ECs0710 NC_002695.1 786116 787780 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 786116..787780 Escherichia coli O157:H7 str. Sakai 917079 NP_308740.1 CDS ECs0713 NC_002695.1 789814 790140 D similar to YBFN_ECOLI gi|1786898 (conserved in Escherichia coli K-12); hypothetical protein 789814..790140 Escherichia coli O157:H7 str. Sakai 917082 NP_308741.1 CDS fur NC_002695.1 790224 790670 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(790224..790670) Escherichia coli O157:H7 str. Sakai 917083 NP_308742.1 CDS ECs0715 NC_002695.1 790959 791489 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(790959..791489) Escherichia coli O157:H7 str. Sakai 917084 NP_308743.1 CDS ECs0716 NC_002695.1 791629 791991 R similar to YBFE_ECOLI gi|1786901 (conserved in Escherichia coli K-12); LexA regulated protein complement(791629..791991) Escherichia coli O157:H7 str. Sakai 917085 NP_308744.1 CDS ECs0717 NC_002695.1 792062 792826 R similar to YBFF_ECOLI gi|1786902 (conserved in Escherichia coli K-12); hypothetical protein complement(792062..792826) Escherichia coli O157:H7 str. Sakai 917086 NP_308745.1 CDS ECs0718 NC_002695.1 793011 793556 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 793011..793556 Escherichia coli O157:H7 str. Sakai 917087 NP_308746.1 CDS ECs0719 NC_002695.1 793582 795222 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 793582..795222 Escherichia coli O157:H7 str. Sakai 917088 NP_308747.1 CDS potE NC_002695.1 795279 796598 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(795279..796598) Escherichia coli O157:H7 str. Sakai 917089 NP_308748.1 CDS ECs0721 NC_002695.1 796595 798793 R similar to SPEF_ECOLI gi|1786909; ornithine decarboxylase complement(796595..798793) Escherichia coli O157:H7 str. Sakai 917090 NP_308749.1 CDS ECs0722 NC_002695.1 799483 800160 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; KdpE family transcriptional regulator complement(799483..800160) Escherichia coli O157:H7 str. Sakai 917091 NP_308750.1 CDS ECs0723 NC_002695.1 800157 802841 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(800157..802841) Escherichia coli O157:H7 str. Sakai 917092 NP_308751.1 CDS ECs0724 NC_002695.1 802834 803406 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(802834..803406) Escherichia coli O157:H7 str. Sakai 917093 NP_308752.1 CDS ECs0725 NC_002695.1 803415 805463 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(803415..805463) Escherichia coli O157:H7 str. Sakai 917094 NP_308753.1 CDS ECs0726 NC_002695.1 805486 807159 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(805486..807159) Escherichia coli O157:H7 str. Sakai 917095 NP_308754.1 CDS kdpF NC_002695.1 807159 807248 R one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit F complement(807159..807248) Escherichia coli O157:H7 str. Sakai 917096 NP_308755.1 CDS ECs0728 NC_002695.1 807561 807767 D similar to YBFA_ECOLI gi|1786916 (conserved in Escherichia coli K-12); hypothetical protein 807561..807767 Escherichia coli O157:H7 str. Sakai 917097 NP_308756.1 CDS ECs0729 NC_002695.1 808009 812208 D core protein with extension; similar to RHSC_ECOLI gi|1786917 and B0703_ECOLI gi|1786921; Rhs protein; protein RhsC 808009..812208 Escherichia coli O157:H7 str. Sakai 917098 NP_308757.1 CDS ECs0730 NC_002695.1 812233 812775 D similar to YBFC_ECOLI gi|1786922; hypothetical protein 812233..812775 Escherichia coli O157:H7 str. Sakai 917099 NP_308758.1 CDS ECs0731 NC_002695.1 814425 815498 D similar to H-repeat assciated proteins e.g. YHHI_ECOLI gi|1789896 (conserved in Escherichia coli K-12); H repeat-containing protein 814425..815498 Escherichia coli O157:H7 str. Sakai 917100 NP_308759.1 CDS ECs0732 NC_002695.1 815647 816156 D similar to YBGA_ECOLI gi|1786925 (conserved in Escherichia coli K-12); hypothetical protein 815647..816156 Escherichia coli O157:H7 str. Sakai 917101 NP_308760.1 CDS ECs0733 NC_002695.1 816153 817571 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 816153..817571 Escherichia coli O157:H7 str. Sakai 917102 NP_308761.1 CDS ECs0734 NC_002695.1 817721 819202 R similar to YBGH_ECOLI gi|1786927 (conserved in Escherichia coli K-12); transporter complement(817721..819202) Escherichia coli O157:H7 str. Sakai 917103 NP_308762.1 CDS ECs0735 NC_002695.1 819473 820216 D similar to YBGI_ECOLI gi|1786928 (conserved in Escherichia coli K-12); hydrolase-oxidase 819473..820216 Escherichia coli O157:H7 str. Sakai 917104 NP_308763.1 CDS ECs0736 NC_002695.1 820239 820895 D similar to YBGJ_ECOLI gi|1786929 (conserved in Escherichia coli K-12); carboxylase 820239..820895 Escherichia coli O157:H7 str. Sakai 917105 NP_308764.1 CDS ECs0737 NC_002695.1 820889 821821 D similar to YBGK_ECOLI gi|1786930 (conserved in Escherichia coli K-12); carboxylase 820889..821821 Escherichia coli O157:H7 str. Sakai 917106 NP_308765.1 CDS ECs0738 NC_002695.1 821811 822545 D similar to YBGL_ECOLI gi|1786931 (conserved in Escherichia coli K-12); LamB/YcsF family protein 821811..822545 Escherichia coli O157:H7 str. Sakai 917107 NP_308766.1 CDS ECs0739 NC_002695.1 822581 823372 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 822581..823372 Escherichia coli O157:H7 str. Sakai 917108 NP_308767.1 CDS ECs0740 NC_002695.1 823369 824460 R similar to ABRB_ECOLI gi|1786933 (conserved in Escherichia coli K-12); transporter complement(823369..824460) Escherichia coli O157:H7 str. Sakai 917109 NP_308768.1 CDS ECs0741 NC_002695.1 824564 825625 R similar to YBGO_ECOLI gi|1786935; hypothetical protein complement(824564..825625) Escherichia coli O157:H7 str. Sakai 917110 NP_308769.1 CDS ECs0742 NC_002695.1 825622 826353 R similar to YBGP_ECOLI gi|1786936; chaperone complement(825622..826353) Escherichia coli O157:H7 str. Sakai 917111 NP_308770.1 CDS ECs0743 NC_002695.1 826656 828827 R similar to YBGQ_ECOLI gi|1786937; truncated due to frameshift; hypothetical protein complement(826656..828827) Escherichia coli O157:H7 str. Sakai 917476 NP_308771.1 CDS ECs0744 NC_002695.1 828877 829458 R similar to YBGD_ECOLI gi|1786938; fimbrial-like protein complement(828877..829458) Escherichia coli O157:H7 str. Sakai 917475 NP_308772.1 CDS gltA NC_002695.1 829830 831113 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(829830..831113) Escherichia coli O157:H7 str. Sakai 917477 NP_308773.1 CDS sdhC NC_002695.1 831822 832211 D similar to SDHC_ECOLI gi|1786940 (conserved in Escherichia coli K-12); succinate dehydrogenase cytochrome b556 large membrane subunit 831822..832211 Escherichia coli O157:H7 str. Sakai 917493 NP_308774.1 CDS sdhD NC_002695.1 832205 832552 D similar to SDHD_ECOLI gi|1786941 (conserved in Escherichia coli K-12); succinate dehydrogenase cytochrome b556 small membrane subunit 832205..832552 Escherichia coli O157:H7 str. Sakai 917478 NP_308775.1 CDS sdhA NC_002695.1 832552 834318 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 832552..834318 Escherichia coli O157:H7 str. Sakai 917480 NP_308776.1 CDS sdhB NC_002695.1 834334 835050 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 834334..835050 Escherichia coli O157:H7 str. Sakai 917482 NP_308777.1 CDS ECs0750 NC_002695.1 835109 835369 D similar to B0725_ECOLI gi|1786944 (conserved in Escherichia coli K-12); hypothetical protein 835109..835369 Escherichia coli O157:H7 str. Sakai 917483 NP_308778.1 CDS sucA NC_002695.1 835351 838152 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 835351..838152 Escherichia coli O157:H7 str. Sakai 917481 NP_308779.1 CDS ECs0752 NC_002695.1 838167 839384 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 838167..839384 Escherichia coli O157:H7 str. Sakai 917484 NP_308780.1 CDS sucC NC_002695.1 839478 840644 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 839478..840644 Escherichia coli O157:H7 str. Sakai 917490 NP_308781.1 CDS ECs0754 NC_002695.1 840644 841513 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 840644..841513 Escherichia coli O157:H7 str. Sakai 917489 NP_308782.1 CDS ECs0755 NC_002695.1 842180 843085 D similar to transcriptional regulators e.g. glycine cleavage system transcription activator (gcv operon activator) - Escherichia coli gi|417043|sp|P32064|GCVA_ECOLI; transcriptional regulator 842180..843085 Escherichia coli O157:H7 str. Sakai 917485 NP_308783.1 CDS ECs0756 NC_002695.1 843119 843721 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(843119..843721) Escherichia coli O157:H7 str. Sakai 917486 NP_308784.1 CDS ECs0757 NC_002695.1 843731 845383 R similar to fumarate hydratase class I, aerobic (fumarase) - Escherichia coli gi|120598|sp|P00923|FUMA_ECOLI; fumarate hydratase complement(843731..845383) Escherichia coli O157:H7 str. Sakai 917487 NP_308785.1 CDS ECs0758 NC_002695.1 845491 846771 R similar to glutamate/aspartate transport proteins (proton glutamate symport proteins) e.g. [Bacillus stearothermophilus] gi|121467|sp|P24943|GLTT_BACST; similar toC4-dicarboxylate transporter; transporter complement(845491..846771) Escherichia coli O157:H7 str. Sakai 917488 NP_308786.1 CDS ECs0759 NC_002695.1 846932 847249 R hypothetical protein complement(846932..847249) Escherichia coli O157:H7 str. Sakai 917499 NP_308787.1 CDS ECs0760 NC_002695.1 847246 848616 R hypothetical protein complement(847246..848616) Escherichia coli O157:H7 str. Sakai 917494 NP_308788.1 CDS ECs0761 NC_002695.1 848620 849861 R beta-methylaspartase; similar to 3-methylaspartate ammonia-lyases (beta-methylaspartases) e.g. [Citrobacter amalonaticus] gi|3184397|dbj|BAA28709.1|; [Clostridium tetanomorphum] gi|729971|sp; 3-methylaspartate ammonia-lyase complement(848620..849861) Escherichia coli O157:H7 str. Sakai 917491 NP_308789.1 CDS ECs0762 NC_002695.1 849861 851306 R methylaspartate mutase E; similar to glutamate mutases e.g. [Citrobacter amalonaticus] gi|3184396|dbj|BAA28708.1|; [Clostridium tetanomorphum] gi|729586|sp|Q05509|GLME_CLOTT; glutamate mutase E complement(849861..851306) Escherichia coli O157:H7 str. Sakai 917492 NP_308790.1 CDS ECs0763 NC_002695.1 851325 852713 R methylaspartate mutase L; similar to glutamate mutase L (methylaspartate mutase L) e.g. [Clostridium tetanomorphum] gi|444421|prf||1907157C; glutamate mutase L complement(851325..852713) Escherichia coli O157:H7 str. Sakai 917495 NP_308791.1 CDS ECs0764 NC_002695.1 852713 853162 R converts methylaspartate to L-glutamate; methylaspartate mutase subunit S complement(852713..853162) Escherichia coli O157:H7 str. Sakai 917503 NP_308793.1 CDS ECs0766 NC_002695.1 853710 854132 R hypothetical protein complement(853710..854132) Escherichia coli O157:H7 str. Sakai 917498 NP_308794.1 CDS ECs0767 NC_002695.1 854214 855158 R hypothetical protein complement(854214..855158) Escherichia coli O157:H7 str. Sakai 917497 NP_308795.1 CDS ECs0768 NC_002695.1 855961 857532 D similar to CYDA_ECOLI gi|1786953 (conserved in Escherichia coli K-12); cytochrome d terminal oxidase polypeptide subunit I 855961..857532 Escherichia coli O157:H7 str. Sakai 917512 NP_308796.1 CDS ECs0769 NC_002695.1 857548 858687 D similar to CYDB_ECOLI gi|1786954 (conserved in Escherichia coli K-12); cytochrome d terminal oxidase polypeptide subunit II 857548..858687 Escherichia coli O157:H7 str. Sakai 917500 NP_944510.1 CDS ECs5391 NC_002695.1 858702 858815 D hypothetical protein 858702..858815 Escherichia coli O157:H7 str. Sakai 2693749 NP_308797.1 CDS ECs0770 NC_002695.1 858815 859108 D similar to YBGE_ECOLI gi|1786956 (conserved in Escherichia coli K-12); hypothetical protein 858815..859108 Escherichia coli O157:H7 str. Sakai 917502 NP_308798.1 CDS ECs0771 NC_002695.1 859258 859662 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 859258..859662 Escherichia coli O157:H7 str. Sakai 917501 NP_308799.1 CDS ECs0772 NC_002695.1 859659 860351 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 859659..860351 Escherichia coli O157:H7 str. Sakai 917505 NP_308800.1 CDS ECs0773 NC_002695.1 860355 860783 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 860355..860783 Escherichia coli O157:H7 str. Sakai 917504 NP_308801.1 CDS tolA NC_002695.1 860848 862032 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 860848..862032 Escherichia coli O157:H7 str. Sakai 917507 NP_308802.1 CDS tolB NC_002695.1 862165 863457 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 862165..863457 Escherichia coli O157:H7 str. Sakai 917506 NP_308803.1 CDS ECs0776 NC_002695.1 863492 864013 D similar to PAL_ECOLI gi|1786962 (conserved in Escherichia coli K-12); peptidoglycan-associated outer membrane lipoprotein 863492..864013 Escherichia coli O157:H7 str. Sakai 917510 NP_308804.1 CDS ECs0777 NC_002695.1 864023 864814 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 864023..864814 Escherichia coli O157:H7 str. Sakai 917508 NP_308805.1 CDS ECs0778 NC_002695.1 865949 866992 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 865949..866992 Escherichia coli O157:H7 str. Sakai 917516 NP_308806.1 CDS ECs0779 NC_002695.1 867030 867749 D similar to PNUC_ECOLI gi|1786965 (conserved in Escherichia coli K-12); protein PnuC 867030..867749 Escherichia coli O157:H7 str. Sakai 917520 NP_308807.1 CDS ECs0780 NC_002695.1 867746 868687 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(867746..868687) Escherichia coli O157:H7 str. Sakai 917515 NP_308808.1 CDS ECs0781 NC_002695.1 868801 869181 R similar to B0753_ECOLI gi|1786968 (conserved in Escherichia coli K-12); homeobox protein complement(868801..869181) Escherichia coli O157:H7 str. Sakai 917518 NP_308809.1 CDS ECs0782 NC_002695.1 869497 870549 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 869497..870549 Escherichia coli O157:H7 str. Sakai 917531 NP_308810.1 CDS gpmA NC_002695.1 870715 871467 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(870715..871467) Escherichia coli O157:H7 str. Sakai 917517 NP_308811.1 CDS galM NC_002695.1 871669 872709 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(871669..872709) Escherichia coli O157:H7 str. Sakai 917521 NP_308812.1 CDS ECs0785 NC_002695.1 872703 873851 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(872703..873851) Escherichia coli O157:H7 str. Sakai 917523 NP_308813.1 CDS ECs0786 NC_002695.1 873855 874901 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(873855..874901) Escherichia coli O157:H7 str. Sakai 917530 NP_308814.2 CDS ECs0787 NC_002695.1 874911 875939 R similar to GALE_ECOLI gi|1786974 (conserved in Escherichia coli K-12); UDP-galactose-4-epimerase complement(874911..875939) Escherichia coli O157:H7 str. Sakai 917525 NP_308815.1 CDS ECs0788 NC_002695.1 876189 877661 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF complement(876189..877661) Escherichia coli O157:H7 str. Sakai 917552 NP_308816.1 CDS ECs0789 NC_002695.1 877729 878517 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; ModE family transcriptional regulator complement(877729..878517) Escherichia coli O157:H7 str. Sakai 917526 NP_308817.1 CDS ECs0790 NC_002695.1 878646 878795 D similar to B0762_ECOLI gi|1786977 (conserved in Escherichia coli K-12); hypothetical protein 878646..878795 Escherichia coli O157:H7 str. Sakai 917527 NP_308818.1 CDS modA NC_002695.1 878962 879735 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 878962..879735 Escherichia coli O157:H7 str. Sakai 917528 NP_308819.1 CDS modB NC_002695.1 879735 880424 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 879735..880424 Escherichia coli O157:H7 str. Sakai 917529 NP_308820.1 CDS modC NC_002695.1 880427 881485 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 880427..881485 Escherichia coli O157:H7 str. Sakai 917533 NP_308821.1 CDS ECs0794 NC_002695.1 881486 882304 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(881486..882304) Escherichia coli O157:H7 str. Sakai 917532 NP_308822.1 CDS ECs0795 NC_002695.1 882459 883454 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 882459..883454 Escherichia coli O157:H7 str. Sakai 917534 NP_308823.2 CDS ECs0796 NC_002695.1 883495 884427 R similar to YBHD_ECOLI gi|1786984 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(883495..884427) Escherichia coli O157:H7 str. Sakai 917536 NP_308824.1 CDS ECs0797 NC_002695.1 884632 885684 D similar to YBHH_ECOLI gi|1786985 (conserved in Escherichia coli K-12); hypothetical protein 884632..885684 Escherichia coli O157:H7 str. Sakai 917538 NP_308825.1 CDS ECs0798 NC_002695.1 885760 887193 D similar to YBHI_ECOLI gi|1786986 (conserved in Escherichia coli K-12); membrane pump protein 885760..887193 Escherichia coli O157:H7 str. Sakai 917537 NP_308826.2 CDS ECs0799 NC_002695.1 887376 889637 D similar to YBHJ_ECOLI gi|1786987 (conserved in Escherichia coli K-12); hypothetical protein 887376..889637 Escherichia coli O157:H7 str. Sakai 917535 NP_308827.1 CDS ECs0800 NC_002695.1 889778 891061 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase complement(889778..891061) Escherichia coli O157:H7 str. Sakai 917540 NP_308828.1 CDS ECs0801 NC_002695.1 892240 892458 R similar to excisionase [Bacteriophage HK022] gi|1722835|sp|P11683|VXIS_BP434 and [Bacteriophage lambda] gi|139680|sp|P03699|VXIS_LAMBD; excisionase complement(892240..892458) Escherichia coli O157:H7 str. Sakai 917539 NP_308829.1 CDS ECs0802 NC_002695.1 892498 892665 R similar to hypothetical protein ORF55 [Bacteriophage 434] gi|801889|gb|AAA67903.1; hypothetical protein complement(892498..892665) Escherichia coli O157:H7 str. Sakai 917541 NP_308831.1 CDS ECs0804 NC_002695.1 892980 893510 D hypothetical protein 892980..893510 Escherichia coli O157:H7 str. Sakai 917548 NP_308832.1 CDS ECs0805 NC_002695.1 893721 893942 R similar to C4-type zinc finger proteins (TraR family) e.g. gi|7649830|dbj|BAA94108.1; hypothetical protein complement(893721..893942) Escherichia coli O157:H7 str. Sakai 917542 NP_308833.2 CDS ECs0806 NC_002695.1 894041 894256 R hypothetical protein complement(894041..894256) Escherichia coli O157:H7 str. Sakai 917543 NP_308834.1 CDS ECs0807 NC_002695.1 894333 894524 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881603|dbj|BAA84294.1, orf63 [Bacteriophage lambda] gi|508994|gb|AAA96567.1; hypothetical protein complement(894333..894524) Escherichia coli O157:H7 str. Sakai 917546 NP_308835.1 CDS ECs0808 NC_002695.1 894497 894679 R similar to hypothetical protein [Bacteriophage 933W] gi|4585389|gb|AAD25417.1|AF125520_12, orf60a [Bacteriophage lambda] gi|508995|gb|AAA96568.1; hypothetical protein complement(894497..894679) Escherichia coli O157:H7 str. Sakai 917547 NP_308836.1 CDS ECs0809 NC_002695.1 894676 895356 R similar to exonucleases e.g. [Bacteriophage lambda] gi|119702|sp|P03697|EXO_LAMBD; exonuclease complement(894676..895356) Escherichia coli O157:H7 str. Sakai 917544 NP_944511.1 CDS ECs5398 NC_002695.1 895353 895997 R hypothetical protein complement(895353..895997) Escherichia coli O157:H7 str. Sakai 2693773 NP_308837.1 CDS ECs0810 NC_002695.1 896054 896236 D similar to NinE [Bacteriophage 21] gi|4539480|emb|CAB39989.1; protein NinE 896054..896236 Escherichia coli O157:H7 str. Sakai 917551 NP_308838.1 CDS ECs0811 NC_002695.1 896233 896403 D similar to NinF [Bacteriophage 21] gi|4539481|emb|CAB39990.1|; protein NinF 896233..896403 Escherichia coli O157:H7 str. Sakai 917550 NP_308839.1 CDS ECs0812 NC_002695.1 896393 897016 D similar to NinG [Bacteriophage 21] gi|4539482|emb|CAB39991.1; protein NinG 896393..897016 Escherichia coli O157:H7 str. Sakai 917549 NP_308840.1 CDS ECs0813 NC_002695.1 897013 897678 D similar to serine/threonin protein phosphatases e.g. [Bacteriophage lambda] gi|130792|sp|P03772|PP_LAMBD; serine/threonin protein phosphatase 897013..897678 Escherichia coli O157:H7 str. Sakai 917554 NP_308841.1 CDS ECs0814 NC_002695.1 897890 898849 R similar to probable outer membrane protein [Helicobacter pylori (strain J99)] gi|7465285|pir||H71907; outer membrane protein complement(897890..898849) Escherichia coli O157:H7 str. Sakai 917556 NP_308842.1 CDS ECs0815 NC_002695.1 899324 900013 D similar to antiterminators e.g. protein Q [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; anti-termination protein 899324..900013 Escherichia coli O157:H7 str. Sakai 917555 NP_308843.2 CDS ECs0816 NC_002695.1 900224 900940 D similar to orf14 [Actinobacillus actinomycetemcomitans] gi|7592819|dbj|BAA94406.1, TfpB protein [Moraxella bovis] gi|141258|sp|P20666|TFPB_MORBO; hypothetical protein 900224..900940 Escherichia coli O157:H7 str. Sakai 917576 NP_308845.1 CDS ECs0818 NC_002695.1 901806 902021 D similar to holin S e .g. [Bacteriophage 933W] gi|4499808|emb|CAB39307.1; holin 901806..902021 Escherichia coli O157:H7 str. Sakai 917559 NP_308846.1 CDS ECs0819 NC_002695.1 902021 902518 D lysozyme; similar to endolysins (lysozyme) e.g. R protein [Bacteriophage 21] gi|67436|pir||LZBP21; endolysin 902021..902518 Escherichia coli O157:H7 str. Sakai 917557 NP_308847.1 CDS ECs0820 NC_002695.1 902515 902982 D similar to hypothetical protein gp15 [Bacteriophage PS119] gi|3676087|emb|CAA09711.1, endopeptidases e.g. [Bacteriophage lambda] gi|67522|pir||APBPML ident; endopeptidase 902515..902982 Escherichia coli O157:H7 str. Sakai 917558 NP_308849.1 CDS ECs0822 NC_002695.1 902970 903122 D hypothetical protein 902970..903122 Escherichia coli O157:H7 str. Sakai 917574 NP_308850.1 CDS ECs0823 NC_002695.1 903529 903807 D hypothetical protein 903529..903807 Escherichia coli O157:H7 str. Sakai 917563 NP_308851.1 CDS ECs0824 NC_002695.1 903797 904288 D hypothetical protein 903797..904288 Escherichia coli O157:H7 str. Sakai 917565 NP_308852.1 CDS ECs0825 NC_002695.1 904288 906390 D similar to terminase large subunits e.g. [Bacteriophage WO] gi|6723224|dbj|BAA89621.1, [Bacteriophage N15] gi|7444579|pir||T13088; terminase large subunit 904288..906390 Escherichia coli O157:H7 str. Sakai 917567 NP_308853.1 CDS ECs0826 NC_002695.1 906387 906599 D hypothetical protein 906387..906599 Escherichia coli O157:H7 str. Sakai 917601 NP_308854.1 CDS ECs0827 NC_002695.1 906527 907651 D similar to portal protein [Wolbachia sp. wKue]gi|6723246|dbj|BAA89642.1|; portal protein 906527..907651 Escherichia coli O157:H7 str. Sakai 917561 NP_308855.1 CDS ECs0828 NC_002695.1 907851 908108 D hypothetical protein 907851..908108 Escherichia coli O157:H7 str. Sakai 917564 NP_308856.1 CDS ECs0829 NC_002695.1 907957 910080 D similar to scaffolding protein [Streptococcus thermophilus bacteriophage DT1] gi|4530143|gb|AAD21883.1, probable protease/scaffold protein, ClpP protease e.g. [Bacteriophage D3] gi|5059251|gb|AAD38956.1; protease/scaffold protein 907957..910080 Escherichia coli O157:H7 str. Sakai 917566 NP_308857.1 CDS ECs0830 NC_002695.1 910122 910490 D hypothetical protein 910122..910490 Escherichia coli O157:H7 str. Sakai 917568 NP_308858.1 CDS ECs0831 NC_002695.1 910483 910758 D hypothetical protein 910483..910758 Escherichia coli O157:H7 str. Sakai 917570 NP_308859.1 CDS ECs0832 NC_002695.1 910770 911348 D similar to minor tail proteins e.g. protein Z [Bacteriophage N15] gi|7521219|pir||T13097, GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein 910770..911348 Escherichia coli O157:H7 str. Sakai 917569 NP_308860.1 CDS ECs0833 NC_002695.1 911345 911746 D similar to minor tail proteins e.g. protein U [Bacteriophage N15] gi|7444588|pir||T13098, GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein 911345..911746 Escherichia coli O157:H7 str. Sakai 917571 NP_308861.1 CDS ECs0834 NC_002695.1 911757 912500 D similar to major tail proteins e.g. protein V [Bacteriophage N15] gi|7444589|pir||T13099, GpV [Bacteriophage lambda] gi|138848|sp|P03733|VMTV_LAMBD; major tail protein 911757..912500 Escherichia coli O157:H7 str. Sakai 917575 NP_308862.1 CDS ECs0835 NC_002695.1 912561 912947 D similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 912561..912947 Escherichia coli O157:H7 str. Sakai 917572 NP_308863.1 CDS ECs0836 NC_002695.1 912956 913285 D similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein 912956..913285 Escherichia coli O157:H7 str. Sakai 917581 NP_308864.1 CDS ECs0837 NC_002695.1 913257 916322 D similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 913257..916322 Escherichia coli O157:H7 str. Sakai 917573 NP_308865.1 CDS ECs0838 NC_002695.1 916322 916651 D similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 916322..916651 Escherichia coli O157:H7 str. Sakai 917577 NP_308866.1 CDS ECs0839 NC_002695.1 916661 917359 D similar to GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 916661..917359 Escherichia coli O157:H7 str. Sakai 917583 NP_308867.1 CDS ECs0840 NC_002695.1 917509 918108 D similar to GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 917509..918108 Escherichia coli O157:H7 str. Sakai 917579 NP_308868.1 CDS ECs0841 NC_002695.1 918006 918653 D similar to GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 918006..918653 Escherichia coli O157:H7 str. Sakai 917580 NP_308869.1 CDS ECs0842 NC_002695.1 918714 922127 D similar to GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 918714..922127 Escherichia coli O157:H7 str. Sakai 917578 NP_308870.1 CDS ECs0843 NC_002695.1 922198 922797 D similar to outer membrane protein Lom precursors e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein 922198..922797 Escherichia coli O157:H7 str. Sakai 917582 NP_308871.1 CDS ECs0844 NC_002695.1 922857 924173 D similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 922857..924173 Escherichia coli O157:H7 str. Sakai 917584 NP_308872.1 CDS ECs0845 NC_002695.1 924136 924444 D similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 924136..924444 Escherichia coli O157:H7 str. Sakai 917586 NP_308873.1 CDS ECs0846 NC_002695.1 924621 925601 D similar to hypothetical protein [Salmonella typhimurium LT2] gi|6960367|gb|AAF33527.1; hypothetical protein 924621..925601 Escherichia coli O157:H7 str. Sakai 917585 NP_308874.1 CDS ECs0847 NC_002695.1 925662 926654 D hypothetical protein 925662..926654 Escherichia coli O157:H7 str. Sakai 917594 NP_308875.1 CDS ECs0848 NC_002695.1 927482 928363 D hypothetical protein 927482..928363 Escherichia coli O157:H7 str. Sakai 917591 NP_308876.1 CDS ECs0849 NC_002695.1 928398 928532 D hypothetical protein 928398..928532 Escherichia coli O157:H7 str. Sakai 917597 NP_308877.1 CDS ECs0850 NC_002695.1 928594 929292 D hypothetical protein 928594..929292 Escherichia coli O157:H7 str. Sakai 917593 NP_308878.1 CDS ECs0851 NC_002695.1 929799 930275 R YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein complement(929799..930275) Escherichia coli O157:H7 str. Sakai 917596 NP_308879.1 CDS ECs0852 NC_002695.1 930334 931623 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(930334..931623) Escherichia coli O157:H7 str. Sakai 917588 NP_308880.1 CDS ECs0853 NC_002695.1 931710 932750 D similar to BIOB_ECOLI gi|1786992 (conserved in Escherichia coli K-12); biotin synthase 931710..932750 Escherichia coli O157:H7 str. Sakai 917589 NP_308881.1 CDS ECs0854 NC_002695.1 932747 933901 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 932747..933901 Escherichia coli O157:H7 str. Sakai 917598 NP_308882.1 CDS ECs0855 NC_002695.1 933888 934643 D methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 933888..934643 Escherichia coli O157:H7 str. Sakai 917590 NP_308883.1 CDS bioD NC_002695.1 934636 935313 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 934636..935313 Escherichia coli O157:H7 str. Sakai 917592 NP_308884.1 CDS ECs0857 NC_002695.1 935892 937913 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 935892..937913 Escherichia coli O157:H7 str. Sakai 917595 NP_308885.1 CDS ECs0858 NC_002695.1 938104 939012 R similar to YBHK_ECOLI gi|1786997 (conserved in Escherichia coli K-12); structural protein complement(938104..939012) Escherichia coli O157:H7 str. Sakai 917602 NP_308886.1 CDS moaA NC_002695.1 939409 940398 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 939409..940398 Escherichia coli O157:H7 str. Sakai 917600 NP_308887.1 CDS ECs0860 NC_002695.1 940420 940932 D similar to MOAB_ECOLI gi|1787000 (conserved in Escherichia coli K-12); molybdenum cofactor biosynthesis protein B 940420..940932 Escherichia coli O157:H7 str. Sakai 917603 NP_308888.1 CDS moaC NC_002695.1 940935 941420 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 940935..941420 Escherichia coli O157:H7 str. Sakai 917613 NP_308889.1 CDS moaD NC_002695.1 941413 941658 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 941413..941658 Escherichia coli O157:H7 str. Sakai 917604 NP_308890.1 CDS moaE NC_002695.1 941660 942112 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 941660..942112 Escherichia coli O157:H7 str. Sakai 917599 NP_308891.1 CDS ECs0864 NC_002695.1 942248 942952 D similar to YBHL_ECOLI gi|1787004 (conserved in Escherichia coli K-12); hypothetical protein 942248..942952 Escherichia coli O157:H7 str. Sakai 917612 NP_308892.1 CDS ECs0865 NC_002695.1 943160 943873 D similar to YBHM_ECOLI gi|1787005 (conserved in Escherichia coli K-12); hypothetical protein 943160..943873 Escherichia coli O157:H7 str. Sakai 917605 NP_308893.1 CDS ECs0866 NC_002695.1 943909 944865 R similar to YBHN_ECOLI gi|1787006 (conserved in Escherichia coli K-12); hypothetical protein complement(943909..944865) Escherichia coli O157:H7 str. Sakai 917606 NP_308894.1 CDS ECs0867 NC_002695.1 944865 946106 R similar to YBHO_ECOLI gi|1787007 (conserved in Escherichia coli K-12); cardiolipin synthase 2 complement(944865..946106) Escherichia coli O157:H7 str. Sakai 917609 NP_308895.1 CDS ECs0868 NC_002695.1 946103 946864 R similar to YBHP_ECOLI gi|1787008 (conserved in Escherichia coli K-12); hypothetical protein complement(946103..946864) Escherichia coli O157:H7 str. Sakai 917610 NP_308896.1 CDS ECs0869 NC_002695.1 946997 947407 D similar to YBHQ_ECOLI gi|1787009 (conserved in Escherichia coli K-12); hypothetical protein 946997..947407 Escherichia coli O157:H7 str. Sakai 917607 NP_308897.1 CDS ECs0870 NC_002695.1 947369 948475 R similar to YBHR_ECOLI gi|1787010 (conserved in Escherichia coli K-12); hypothetical protein complement(947369..948475) Escherichia coli O157:H7 str. Sakai 917635 NP_308898.1 CDS ECs0871 NC_002695.1 948486 949619 R similar to YBHS_ECOLI gi|1787011 (conserved in Escherichia coli K-12); hypothetical protein complement(948486..949619) Escherichia coli O157:H7 str. Sakai 917608 NP_308899.2 CDS ECs0872 NC_002695.1 949612 951348 R similar to YBHF_ECOLI gi|1787012 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(949612..951348) Escherichia coli O157:H7 str. Sakai 917634 NP_308900.1 CDS ECs0873 NC_002695.1 951341 952339 R similar to B0795_ECOLI gi|1787013 (conserved in Escherichia coli K-12); hypothetical protein complement(951341..952339) Escherichia coli O157:H7 str. Sakai 917611 NP_308901.1 CDS ECs0874 NC_002695.1 952339 953022 R similar to YBIH_ECOLI gi|1787014 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator complement(952339..953022) Escherichia coli O157:H7 str. Sakai 917615 NP_308902.1 CDS ECs0875 NC_002695.1 953239 954606 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 953239..954606 Escherichia coli O157:H7 str. Sakai 917614 NP_308903.1 CDS ECs0876 NC_002695.1 955214 957226 D similar to secreted effector protein SopA [Salmonella dublin] gi|5669806|gb|AAD46479.1|AF121227_1 and YjBI [Escherichia coli] gi|418540|sp|P32690|YJBI_ECOLI; hypothetical protein 955214..957226 Escherichia coli O157:H7 str. Sakai 917617 NP_308904.1 CDS dinG NC_002695.1 957510 959660 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 957510..959660 Escherichia coli O157:H7 str. Sakai 917619 NP_308905.1 CDS ECs0878 NC_002695.1 959688 960650 D similar to YBIB_ECOLI gi|1787019 (conserved in Escherichia coli K-12); glycosyl transferase family protein 959688..960650 Escherichia coli O157:H7 str. Sakai 917616 NP_308906.1 CDS ECs0879 NC_002695.1 960791 961876 D similar to YBIC_ECOLI gi|1787020 (conserved in Escherichia coli K-12); hypothetical protein 960791..961876 Escherichia coli O157:H7 str. Sakai 917618 NP_308907.1 CDS ECs0880 NC_002695.1 962105 962365 R similar to YBIJ_ECOLI gi|1787021 (conserved in Escherichia coli K-12); hypothetical protein complement(962105..962365) Escherichia coli O157:H7 str. Sakai 917624 NP_308908.1 CDS ECs0881 NC_002695.1 962630 962896 R similar to YBII_ECOLI gi|1787022 (conserved in Escherichia coli K-12); hypothetical protein complement(962630..962896) Escherichia coli O157:H7 str. Sakai 917620 NP_308909.2 CDS ECs0882 NC_002695.1 962972 963658 R similar to YBIX_ECOLI gi|1787023 (conserved in Escherichia coli K-12); hydroxylase complement(962972..963658) Escherichia coli O157:H7 str. Sakai 917621 NP_308910.1 CDS ECs0883 NC_002695.1 963700 965982 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(963700..965982) Escherichia coli O157:H7 str. Sakai 917629 NP_308911.1 CDS ECs0884 NC_002695.1 966247 966651 R similar to YBIM_ECOLI gi|1787026 (conserved in Escherichia coli K-12); hypothetical protein complement(966247..966651) Escherichia coli O157:H7 str. Sakai 917622 NP_308912.1 CDS ECs0885 NC_002695.1 966702 967709 D similar to YBIN_ECOLI gi|1787027 (conserved in Escherichia coli K-12); SAM-dependent methyltransferase 966702..967709 Escherichia coli O157:H7 str. Sakai 917626 NP_308913.1 CDS ECs0886 NC_002695.1 967706 969931 R similar to YBIO_ECOLI gi|1787028 (conserved in Escherichia coli K-12); hypothetical protein complement(967706..969931) Escherichia coli O157:H7 str. Sakai 917623 NP_308914.1 CDS glnQ NC_002695.1 970048 970770 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(970048..970770) Escherichia coli O157:H7 str. Sakai 917625 NP_308915.1 CDS glnP NC_002695.1 970767 971426 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(970767..971426) Escherichia coli O157:H7 str. Sakai 917627 NP_308916.1 CDS glnH NC_002695.1 971564 972310 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(971564..972310) Escherichia coli O157:H7 str. Sakai 917628 NP_308917.1 CDS ECs0890 NC_002695.1 972714 973217 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(972714..973217) Escherichia coli O157:H7 str. Sakai 917630 NP_308918.1 CDS ECs0891 NC_002695.1 973516 974403 R similar to YBIF_ECOLI gi|1787033 (conserved in Escherichia coli K-12); threonine and homoserine efflux system complement(973516..974403) Escherichia coli O157:H7 str. Sakai 917633 NP_308919.1 CDS ompX NC_002695.1 974756 975271 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 974756..975271 Escherichia coli O157:H7 str. Sakai 917632 NP_308920.1 CDS ECs0893 NC_002695.1 975320 976903 R similar to YBIP_ECOLI gi|1787035 (conserved in Escherichia coli K-12); hypothetical protein complement(975320..976903) Escherichia coli O157:H7 str. Sakai 917631 NP_308921.1 CDS ECs0894 NC_002695.1 977489 977956 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 977489..977956 Escherichia coli O157:H7 str. Sakai 917636 NP_308922.1 CDS ECs0895 NC_002695.1 977953 979071 D similar to YBIR_ECOLI gi|1787039 (conserved in Escherichia coli K-12); hypothetical protein 977953..979071 Escherichia coli O157:H7 str. Sakai 917639 NP_308923.1 CDS ECs0896 NC_002695.1 979129 980049 R similar to YBIS_ECOLI gi|1787040 (conserved in Escherichia coli K-12); hypothetical protein complement(979129..980049) Escherichia coli O157:H7 str. Sakai 917644 NP_308924.1 CDS ECs0897 NC_002695.1 980268 981860 D similar to YBIT_ECOLI gi|1787041 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 980268..981860 Escherichia coli O157:H7 str. Sakai 917637 NP_308925.1 CDS ECs0898 NC_002695.1 982028 983293 R similar to YBIU_ECOLI gi|1787042 (conserved in Escherichia coli K-12); hypothetical protein complement(982028..983293) Escherichia coli O157:H7 str. Sakai 917647 NP_308926.1 CDS ECs0899 NC_002695.1 983445 984260 R similar to B0822_ECOLI gi|1787043 (conserved in Escherichia coli K-12); hypothetical protein complement(983445..984260) Escherichia coli O157:H7 str. Sakai 917640 NP_308929.1 CDS ECs0902 NC_002695.1 986843 987742 R similar to YBIY_ECOLI gi|1787045 (conserved in Escherichia coli K-12); pyruvate formate-lyase 2 activating enzyme complement(986843..987742) Escherichia coli O157:H7 str. Sakai 917645 NP_308930.3 CDS ECs0903 NC_002695.1 987873 988535 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 987873..988535 Escherichia coli O157:H7 str. Sakai 917642 NP_308931.1 CDS ECs0904 NC_002695.1 988714 989463 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(988714..989463) Escherichia coli O157:H7 str. Sakai 917657 NP_308932.1 CDS ECs0905 NC_002695.1 989463 990698 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(989463..990698) Escherichia coli O157:H7 str. Sakai 917643 NP_308935.1 CDS ECs0908 NC_002695.1 991887 993725 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 991887..993725 Escherichia coli O157:H7 str. Sakai 917648 NP_308936.1 CDS ECs0909 NC_002695.1 993745 995283 D similar to B0830_ECOLI gi|1787052 (conserved in Escherichia coli K-12); transporter 993745..995283 Escherichia coli O157:H7 str. Sakai 917655 NP_308937.1 CDS ECs0910 NC_002695.1 995301 996221 D similar to B0831_ECOLI gi|1787053 (conserved in Escherichia coli K-12); transport system permease 995301..996221 Escherichia coli O157:H7 str. Sakai 917654 NP_308938.1 CDS ECs0911 NC_002695.1 996224 997135 D similar to B0832_ECOLI gi|1787054 (conserved in Escherichia coli K-12); transport system permease 996224..997135 Escherichia coli O157:H7 str. Sakai 917649 NP_308939.1 CDS ECs0912 NC_002695.1 997313 999661 D similar to B0833_ECOLI gi|1787055 (conserved in Escherichia coli K-12); hypothetical protein 997313..999661 Escherichia coli O157:H7 str. Sakai 917651 NP_308940.1 CDS ECs0913 NC_002695.1 999669 1000997 D similar to B0834_ECOLI gi|1787056 (conserved in Escherichia coli K-12); hypothetical protein 999669..1000997 Escherichia coli O157:H7 str. Sakai 917650 NP_308941.1 CDS ECs0914 NC_002695.1 1001038 1001532 D hypothetical protein 1001038..1001532 Escherichia coli O157:H7 str. Sakai 917653 NP_944512.1 CDS ECs5399 NC_002695.1 1001067 1001396 R hypothetical protein complement(1001067..1001396) Escherichia coli O157:H7 str. Sakai 2693752 NP_944513.1 CDS ECs5400 NC_002695.1 1001386 1001772 R hypothetical protein complement(1001386..1001772) Escherichia coli O157:H7 str. Sakai 2693753 NP_308942.1 CDS rimO NC_002695.1 1001998 1003323 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(1001998..1003323) Escherichia coli O157:H7 str. Sakai 917659 NP_308943.1 CDS bssR NC_002695.1 1003536 1003919 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 1003536..1003919 Escherichia coli O157:H7 str. Sakai 917658 NP_308944.1 CDS ECs0917 NC_002695.1 1004030 1005145 D similar to YLII_ECOLI gi|1787060 (conserved in Escherichia coli K-12); dehydrogenase 1004030..1005145 Escherichia coli O157:H7 str. Sakai 917664 NP_308945.2 CDS ECs0918 NC_002695.1 1005142 1005768 R similar to YLIJ_ECOLI gi|1787061 (conserved in Escherichia coli K-12); transferase complement(1005142..1005768) Escherichia coli O157:H7 str. Sakai 917656 NP_308946.1 CDS ECs0919 NC_002695.1 1006014 1007216 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1006014..1007216 Escherichia coli O157:H7 str. Sakai 917665 NP_308947.1 CDS ECs0920 NC_002695.1 1007263 1008021 R similar to DEOR_ECOLI gi|1787063 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator complement(1007263..1008021) Escherichia coli O157:H7 str. Sakai 917661 NP_308948.1 CDS ECs0921 NC_002695.1 1008079 1008675 R similar to YBJG_ECOLI gi|1787064 (conserved in Escherichia coli K-12); undecaprenyl pyrophosphate phosphatase complement(1008079..1008675) Escherichia coli O157:H7 str. Sakai 917663 NP_308949.1 CDS ECs0922 NC_002695.1 1008960 1010192 D similar to CMR_ECOLI gi|1787065 (conserved in Escherichia coli K-12); proton motive force efflux pump 1008960..1010192 Escherichia coli O157:H7 str. Sakai 917662 NP_308950.1 CDS ECs0923 NC_002695.1 1010233 1010517 R similar to YBJH_ECOLI gi|1787066 (conserved in Escherichia coli K-12); hypothetical protein complement(1010233..1010517) Escherichia coli O157:H7 str. Sakai 917667 NP_308951.2 CDS ECs0924 NC_002695.1 1010603 1011418 R similar to B0844_ECOLI gi|1787067 (conserved in Escherichia coli K-12); hypothetical protein complement(1010603..1011418) Escherichia coli O157:H7 str. Sakai 917672 NP_308952.1 CDS ECs0925 NC_002695.1 1011418 1012626 R similar to B0845_ECOLI gi|1787068 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator complement(1011418..1012626) Escherichia coli O157:H7 str. Sakai 917671 NP_308953.1 CDS ECs0926 NC_002695.1 1012710 1013246 D similar to B0846_ECOLI gi|1787069 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 1012710..1013246 Escherichia coli O157:H7 str. Sakai 917666 NP_308954.1 CDS ECs0927 NC_002695.1 1013421 1015106 R similar to B0847_ECOLI gi|1787071 (conserved in Escherichia coli K-12); hypothetical protein complement(1013421..1015106) Escherichia coli O157:H7 str. Sakai 917673 NP_308955.1 CDS ECs0928 NC_002695.1 1015376 1015753 D similar to YBJM_ECOLI gi|1787072 (conserved in Escherichia coli K-12); hypothetical protein 1015376..1015753 Escherichia coli O157:H7 str. Sakai 917668 NP_308956.1 CDS grxA NC_002695.1 1015783 1016040 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin complement(1015783..1016040) Escherichia coli O157:H7 str. Sakai 917669 NP_308957.1 CDS ECs0930 NC_002695.1 1016200 1016487 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 1016200..1016487 Escherichia coli O157:H7 str. Sakai 917670 NP_308958.1 CDS ECs0931 NC_002695.1 1016471 1017193 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 1016471..1017193 Escherichia coli O157:H7 str. Sakai 917693 NP_308959.1 CDS ECs0932 NC_002695.1 1017254 1018156 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 1017254..1018156 Escherichia coli O157:H7 str. Sakai 917687 NP_308960.1 CDS ECs0933 NC_002695.1 1018244 1018720 D similar to YBJN_ECOLI gi|1787077 (conserved in Escherichia coli K-12); sensory transduction regulator 1018244..1018720 Escherichia coli O157:H7 str. Sakai 917677 NP_308961.1 CDS ECs0934 NC_002695.1 1019071 1020183 D similar to POTF_ECOLI gi|1787078 (conserved in Escherichia coli K-12); putrescine ABC transporter periplasmic-binding protein 1019071..1020183 Escherichia coli O157:H7 str. Sakai 917675 NP_308962.1 CDS potG NC_002695.1 1020278 1021411 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding protein 1020278..1021411 Escherichia coli O157:H7 str. Sakai 917674 NP_308963.1 CDS ECs0936 NC_002695.1 1021421 1022374 D similar to POTH_ECOLI gi|1787080 (conserved in Escherichia coli K-12); putrescine ABC transporter membrane protein 1021421..1022374 Escherichia coli O157:H7 str. Sakai 917676 NP_308964.1 CDS ECs0937 NC_002695.1 1022371 1023216 D similar to POTI_ECOLI gi|1787081 (conserved in Escherichia coli K-12); putrescine ABC transporter membrane protein 1022371..1023216 Escherichia coli O157:H7 str. Sakai 917680 NP_308965.1 CDS ECs0938 NC_002695.1 1023276 1023764 D similar to YBJO_ECOLI gi|1787082 (conserved in Escherichia coli K-12); hypothetical protein 1023276..1023764 Escherichia coli O157:H7 str. Sakai 917683 NP_308966.1 CDS rumB NC_002695.1 1023805 1024932 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1023805..1024932 Escherichia coli O157:H7 str. Sakai 917679 NP_308967.1 CDS ulaA NC_002695.1 1025212 1026555 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1025212..1026555 Escherichia coli O157:H7 str. Sakai 917678 NP_308968.1 CDS ECs0941 NC_002695.1 1026577 1026897 D similar to phosphotransferase system enzymes IIB e.g. [Escherichia coli] gi|732028|sp|P39302|PTXB_ECOLI; PTS system enzyme IIB 1026577..1026897 Escherichia coli O157:H7 str. Sakai 917681 NP_308969.1 CDS ECs0942 NC_002695.1 1026909 1028390 D hypothetical protein 1026909..1028390 Escherichia coli O157:H7 str. Sakai 917684 NP_308970.1 CDS ECs0943 NC_002695.1 1028441 1029172 R similar to ARTJ_ECOLI gi|1787085 (conserved in Escherichia coli K-12); arginine ABC transporter substrate-binding protein complement(1028441..1029172) Escherichia coli O157:H7 str. Sakai 917682 NP_308971.1 CDS artM NC_002695.1 1029463 1030131 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease ArtM complement(1029463..1030131) Escherichia coli O157:H7 str. Sakai 917725 NP_308972.1 CDS ECs0945 NC_002695.1 1030131 1030847 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease ArtQ complement(1030131..1030847) Escherichia coli O157:H7 str. Sakai 917685 NP_308973.1 CDS ECs0946 NC_002695.1 1030854 1031585 R similar to ARTI_ECOLI gi|1787088 (conserved in Escherichia coli K-12); arginine ABC transporter substrate-binding protein complement(1030854..1031585) Escherichia coli O157:H7 str. Sakai 917686 NP_308974.1 CDS artP NC_002695.1 1031603 1032331 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding protein complement(1031603..1032331) Escherichia coli O157:H7 str. Sakai 917689 NP_308975.1 CDS ECs0948 NC_002695.1 1032549 1033064 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein complement(1032549..1033064) Escherichia coli O157:H7 str. Sakai 917688 NP_308978.1 CDS ECs0951 NC_002695.1 1035462 1035650 R hypothetical protein complement(1035462..1035650) Escherichia coli O157:H7 str. Sakai 917690 NP_308979.1 CDS ECs0952 NC_002695.1 1035705 1036028 D similar to B0866_ECOLI gi|1787091 (conserved in Escherichia coli K-12); hypothetical protein 1035705..1036028 Escherichia coli O157:H7 str. Sakai 917708 NP_308980.1 CDS ECs0953 NC_002695.1 1036025 1036855 D similar to B0867_ECOLI gi|1787092 (conserved in Escherichia coli K-12); regulator 1036025..1036855 Escherichia coli O157:H7 str. Sakai 917694 NP_308981.1 CDS ECs0954 NC_002695.1 1036852 1037901 R similar to B0868_ECOLI gi|1787093 (conserved in Escherichia coli K-12); nucleotide di-P-sugar epimerase or dehydratase complement(1036852..1037901) Escherichia coli O157:H7 str. Sakai 917696 NP_308982.1 CDS ECs0955 NC_002695.1 1037964 1039394 R similar to YBJT_ECOLI gi|1787094 (conserved in Escherichia coli K-12); dTDP-glucose enzyme complement(1037964..1039394) Escherichia coli O157:H7 str. Sakai 917697 NP_308983.1 CDS ECs0956 NC_002695.1 1039405 1040406 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(1039405..1040406) Escherichia coli O157:H7 str. Sakai 917698 NP_308984.1 CDS ECs0957 NC_002695.1 1040443 1042161 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(1040443..1042161) Escherichia coli O157:H7 str. Sakai 917701 NP_308985.1 CDS ECs0958 NC_002695.1 1042294 1043262 R similar to HCR_ECOLI gi|7387728 (conserved in Escherichia coli K-12); HCP oxidoreductase complement(1042294..1043262) Escherichia coli O157:H7 str. Sakai 917695 NP_308986.2 CDS ECs0959 NC_002695.1 1043274 1044926 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(1043274..1044926) Escherichia coli O157:H7 str. Sakai 917700 NP_308987.1 CDS ECs0960 NC_002695.1 1045070 1045969 R similar to surface protein YBJE_ECOLI gi|1787100 (conserved in Escherichia coli K-12); surface protein complement(1045070..1045969) Escherichia coli O157:H7 str. Sakai 917705 NP_308988.1 CDS ECs0961 NC_002695.1 1046427 1047122 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(1046427..1047122) Escherichia coli O157:H7 str. Sakai 917703 NP_308989.1 CDS ECs0962 NC_002695.1 1047548 1049206 D similar to YBJD_ECOLI gi|1787102 (conserved in Escherichia coli K-12); hypothetical protein 1047548..1049206 Escherichia coli O157:H7 str. Sakai 917699 NP_308990.1 CDS ECs0963 NC_002695.1 1049203 1050195 R similar to YBJX_ECOLI gi|1787103 (conserved in Escherichia coli K-12); hypothetical protein complement(1049203..1050195) Escherichia coli O157:H7 str. Sakai 917707 NP_308991.2 CDS ECs0964 NC_002695.1 1050310 1051425 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 1050310..1051425 Escherichia coli O157:H7 str. Sakai 917702 NP_308992.1 CDS ECs0965 NC_002695.1 1051422 1053368 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 1051422..1053368 Escherichia coli O157:H7 str. Sakai 917704 NP_308993.1 CDS ECs0966 NC_002695.1 1053441 1053665 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(1053441..1053665) Escherichia coli O157:H7 str. Sakai 917710 NP_308994.1 CDS clpS NC_002695.1 1053988 1054308 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1053988..1054308 Escherichia coli O157:H7 str. Sakai 917706 NP_308995.1 CDS clpA NC_002695.1 1054339 1056615 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding protein 1054339..1056615 Escherichia coli O157:H7 str. Sakai 917711 NP_308996.1 CDS infA NC_002695.1 1057302 1057520 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(1057302..1057520) Escherichia coli O157:H7 str. Sakai 917713 NP_308997.1 CDS aat NC_002695.1 1057805 1058509 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(1057805..1058509) Escherichia coli O157:H7 str. Sakai 917712 NP_308998.1 CDS ECs0971 NC_002695.1 1058551 1060272 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(1058551..1060272) Escherichia coli O157:H7 str. Sakai 917716 NP_308999.1 CDS ECs0972 NC_002695.1 1060273 1062039 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(1060273..1062039) Escherichia coli O157:H7 str. Sakai 917714 NP_309000.1 CDS ECs0973 NC_002695.1 1062162 1063127 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(1062162..1063127) Escherichia coli O157:H7 str. Sakai 917715 NP_309001.1 CDS ECs0974 NC_002695.1 1063672 1064166 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1063672..1064166 Escherichia coli O157:H7 str. Sakai 917724 NP_309002.1 CDS ECs0975 NC_002695.1 1064301 1068329 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 1064301..1068329 Escherichia coli O157:H7 str. Sakai 917727 NP_309003.1 CDS lolA NC_002695.1 1068481 1069095 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1068481..1069095 Escherichia coli O157:H7 str. Sakai 917717 NP_309004.1 CDS ECs0977 NC_002695.1 1069106 1070449 D similar to YCAJ_ECOLI gi|1787119 (conserved in Escherichia coli K-12); recombination factor protein RarA 1069106..1070449 Escherichia coli O157:H7 str. Sakai 917730 NP_309005.1 CDS ECs0978 NC_002695.1 1070540 1071832 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1070540..1071832 Escherichia coli O157:H7 str. Sakai 917719 NP_309006.2 CDS ECs0979 NC_002695.1 1072071 1074515 D similar to DMSA_ECOLI gi|1787121 (conserved in Escherichia coli K-12); anaerobic dimethyl sulfoxide reductase subunit A 1072071..1074515 Escherichia coli O157:H7 str. Sakai 917718 NP_309007.1 CDS ECs0980 NC_002695.1 1074526 1075143 D similar to DMSB_ECOLI gi|1787122 (conserved in Escherichia coli K-12); anaerobic dimethyl sulfoxide reductase subunit B 1074526..1075143 Escherichia coli O157:H7 str. Sakai 917721 NP_309008.1 CDS ECs0981 NC_002695.1 1075145 1076008 D similar to DMSC_ECOLI gi|1787123 (conserved in Escherichia coli K-12); anaerobic dimethyl sulfoxide reductase subunit C 1075145..1076008 Escherichia coli O157:H7 str. Sakai 917729 NP_309009.1 CDS ECs0982 NC_002695.1 1076044 1076670 R similar to YCAC_ECOLI gi|1787124 (conserved in Escherichia coli K-12); hypothetical protein complement(1076044..1076670) Escherichia coli O157:H7 str. Sakai 917720 NP_309010.1 CDS ECs0983 NC_002695.1 1076985 1078133 D similar to YCAD_ECOLI gi|1787126 (conserved in Escherichia coli K-12); MFS family transporter protein 1076985..1078133 Escherichia coli O157:H7 str. Sakai 917726 NP_309011.1 CDS ECs0984 NC_002695.1 1078151 1079773 D similar to B0899_ECOLI gi|1787127 (conserved in Escherichia coli K-12); transport 1078151..1079773 Escherichia coli O157:H7 str. Sakai 917722 NP_309012.1 CDS pflA NC_002695.1 1079983 1080723 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(1079983..1080723) Escherichia coli O157:H7 str. Sakai 917728 NP_309013.1 CDS ECs0986 NC_002695.1 1080915 1083197 R similar to PFLB_ECOLI gi|1787131 (conserved in Escherichia coli K-12); formate acetyltransferase 1 complement(1080915..1083197) Escherichia coli O157:H7 str. Sakai 917731 NP_309014.1 CDS ECs0987 NC_002695.1 1083252 1084109 R similar to FOCA_ECOLI gi|1787132 (conserved in Escherichia coli K-12); formate transporter complement(1083252..1084109) Escherichia coli O157:H7 str. Sakai 917772 NP_309015.2 CDS ECs0988 NC_002695.1 1084515 1086275 R similar to YCAO_ECOLI gi|1787133 (conserved in Escherichia coli K-12); hypothetical protein complement(1084515..1086275) Escherichia coli O157:H7 str. Sakai 917732 NP_309016.1 CDS ECs0989 NC_002695.1 1086405 1087097 D similar to YCAP_ECOLI gi|1787135 (conserved in Escherichia coli K-12); hypothetical protein 1086405..1087097 Escherichia coli O157:H7 str. Sakai 917738 NP_309017.1 CDS ECs0990 NC_002695.1 1087296 1088384 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1087296..1088384 Escherichia coli O157:H7 str. Sakai 917733 NP_309018.1 CDS ECs0991 NC_002695.1 1088455 1089738 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1088455..1089738 Escherichia coli O157:H7 str. Sakai 917735 NP_309019.1 CDS ECs0992 NC_002695.1 1089883 1090671 D similar to YCAL_ECOLI gi|1787138 (conserved in Escherichia coli K-12); heat shock protein 1089883..1090671 Escherichia coli O157:H7 str. Sakai 917737 NP_309020.1 CDS cmk NC_002695.1 1090844 1091527 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1090844..1091527 Escherichia coli O157:H7 str. Sakai 917734 NP_309021.1 CDS rpsA NC_002695.1 1091638 1093311 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1091638..1093311 Escherichia coli O157:H7 str. Sakai 917736 NP_309022.1 CDS ihfB NC_002695.1 1093471 1093755 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1093471..1093755 Escherichia coli O157:H7 str. Sakai 917740 NP_309023.2 CDS ECs0996 NC_002695.1 1093962 1096226 D similar to YCAI_ECOLI gi|1787142 (conserved in Escherichia coli K-12); hypothetical protein 1093962..1096226 Escherichia coli O157:H7 str. Sakai 917743 NP_309024.1 CDS ECs0997 NC_002695.1 1096263 1098011 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 1096263..1098011 Escherichia coli O157:H7 str. Sakai 917742 NP_309025.1 CDS lpxK NC_002695.1 1098008 1098994 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1098008..1098994 Escherichia coli O157:H7 str. Sakai 917752 NP_309026.1 CDS ECs0999 NC_002695.1 1099031 1100263 D similar to YCAQ_ECOLI gi|1787145 (conserved in Escherichia coli K-12); hypothetical protein 1099031..1100263 Escherichia coli O157:H7 str. Sakai 917741 NP_309027.1 CDS ECs1000 NC_002695.1 1100315 1100497 D similar to YCAR_ECOLI gi|1787146 (conserved in Escherichia coli K-12); hypothetical protein 1100315..1100497 Escherichia coli O157:H7 str. Sakai 917739 NP_309028.1 CDS ECs1001 NC_002695.1 1100494 1101240 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1100494..1101240 Escherichia coli O157:H7 str. Sakai 917744 NP_309029.1 CDS ECs1002 NC_002695.1 1101394 1102287 D similar to B0919_ECOLI gi|1787149 (conserved in Escherichia coli K-12); hypothetical protein 1101394..1102287 Escherichia coli O157:H7 str. Sakai 917745 NP_309030.1 CDS ECs1003 NC_002695.1 1102264 1103043 R similar to YCBC_ECOLI gi|1787150 (conserved in Escherichia coli K-12); hypothetical protein complement(1102264..1103043) Escherichia coli O157:H7 str. Sakai 917746 NP_309031.1 CDS ECs1004 NC_002695.1 1103179 1103964 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1103179..1103964 Escherichia coli O157:H7 str. Sakai 917747 NP_309032.1 CDS ECs1005 NC_002695.1 1103961 1105283 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1103961..1105283 Escherichia coli O157:H7 str. Sakai 917748 NP_309033.1 CDS ECs1006 NC_002695.1 1105264 1105968 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1105264..1105968 Escherichia coli O157:H7 str. Sakai 917749 NP_309034.1 CDS mukB NC_002695.1 1105968 1110428 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1105968..1110428 Escherichia coli O157:H7 str. Sakai 917753 NP_309035.1 CDS ECs1008 NC_002695.1 1110689 1112536 D similar to YCBB_ECOLI gi|1787155 (conserved in Escherichia coli K-12); hypothetical protein 1110689..1112536 Escherichia coli O157:H7 str. Sakai 917750 NP_309036.1 CDS ECs1009 NC_002695.1 1112717 1113265 D similar to YCBK_ECOLI gi|1787157 (conserved in Escherichia coli K-12); hypothetical protein 1112717..1113265 Escherichia coli O157:H7 str. Sakai 917754 NP_309037.1 CDS ECs1010 NC_002695.1 1113292 1113939 D similar to YCBL_ECOLI gi|1787158 (conserved in Escherichia coli K-12); hypothetical protein 1113292..1113939 Escherichia coli O157:H7 str. Sakai 917751 NP_309038.1 CDS ECs1011 NC_002695.1 1113990 1115180 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1113990..1115180) Escherichia coli O157:H7 str. Sakai 917755 NP_309039.1 CDS ECs1012 NC_002695.1 1115365 1116453 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(1115365..1116453) Escherichia coli O157:H7 str. Sakai 917757 NP_309040.1 CDS asnC NC_002695.1 1117056 1118456 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1117056..1118456) Escherichia coli O157:H7 str. Sakai 917756 NP_309041.1 CDS ECs1014 NC_002695.1 1118625 1119827 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1118625..1119827) Escherichia coli O157:H7 str. Sakai 917759 NP_309042.1 CDS pepN NC_002695.1 1120093 1122705 D similar to PEPN_ECOLI gi|1787163 (conserved in Escherichia coli K-12); aminopeptidase 1120093..1122705 Escherichia coli O157:H7 str. Sakai 917763 NP_309043.1 CDS ssuB NC_002695.1 1122748 1123515 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding protein and SsuC the permease; aliphatic sulfonates transport ATP-binding protein complement(1122748..1123515) Escherichia coli O157:H7 str. Sakai 917760 NP_309044.1 CDS ssuC NC_002695.1 1123512 1124303 R part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding protein and SsuC the permease; alkanesulfonate transporter permease complement(1123512..1124303) Escherichia coli O157:H7 str. Sakai 917758 NP_309045.1 CDS ECs1018 NC_002695.1 1124315 1125460 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(1124315..1125460) Escherichia coli O157:H7 str. Sakai 917762 NP_309046.1 CDS ECs1019 NC_002695.1 1125457 1126416 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding protein and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(1125457..1126416) Escherichia coli O157:H7 str. Sakai 917766 NP_309047.1 CDS ECs1020 NC_002695.1 1126409 1126984 R similar to SSUE_ECOLI gi|2507138 (conserved in Escherichia coli K-12); NAD(P)H-dependent FMN reductase complement(1126409..1126984) Escherichia coli O157:H7 str. Sakai 917761 NP_309048.1 CDS ECs1021 NC_002695.1 1127331 1127879 D similar to YCBQ_ECOLI gi|1787170 (conserved in Escherichia coli K-12); fimbrial-like protein 1127331..1127879 Escherichia coli O157:H7 str. Sakai 917768 NP_309049.1 CDS ECs1022 NC_002695.1 1127962 1128663 D similar to YCBR_ECOLI gi|1787171 (conserved in Escherichia coli K-12); chaperone 1127962..1128663 Escherichia coli O157:H7 str. Sakai 917764 NP_309052.1 CDS ECs1025 NC_002695.1 1131278 1132258 D similar to Salmonella FimH protein and B0941_ECOLI gi|1787173 (conserved in Escherichia coli K-12); FimH-like protein 1131278..1132258 Escherichia coli O157:H7 str. Sakai 917767 NP_309053.1 CDS ECs1026 NC_002695.1 1132706 1132903 D similar to fimbrial-like protein B0942_ECOLI gi|1787174; hypothetical protein 1132706..1132903 Escherichia coli O157:H7 str. Sakai 917770 NP_309054.1 CDS ECs1027 NC_002695.1 1132863 1133426 D similar to B0943_ECOLI gi|1787175 (conserved in Escherichia coli K-12); fimbrial-like protein 1132863..1133426 Escherichia coli O157:H7 str. Sakai 917778 NP_309055.1 CDS ECs1028 NC_002695.1 1133392 1133961 D similar to chaperone YCBF_ECOLI gi|1787176; hypothetical protein 1133392..1133961 Escherichia coli O157:H7 str. Sakai 917769 NP_309056.1 CDS ECs1029 NC_002695.1 1134239 1135249 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1134239..1135249 Escherichia coli O157:H7 str. Sakai 917771 NP_309057.2 CDS ECs1030 NC_002695.1 1135423 1135965 D similar to YCBW_ECOLI gi|1787178 (conserved in Escherichia coli K-12); hypothetical protein 1135423..1135965 Escherichia coli O157:H7 str. Sakai 917775 NP_309058.1 CDS ECs1031 NC_002695.1 1135962 1137071 R similar to B0947_ECOLI gi|1787179 (conserved in Escherichia coli K-12); hypothetical protein complement(1135962..1137071) Escherichia coli O157:H7 str. Sakai 917774 NP_309059.1 CDS rlmL NC_002695.1 1137315 1139423 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1137315..1139423 Escherichia coli O157:H7 str. Sakai 917780 NP_309060.1 CDS ECs1033 NC_002695.1 1139435 1141342 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1139435..1141342 Escherichia coli O157:H7 str. Sakai 917781 NP_309061.1 CDS ECs1034 NC_002695.1 1141472 1142725 D similar to PQIA_ECOLI gi|1787183 (conserved in Escherichia coli K-12); paraquat-inducible protein A 1141472..1142725 Escherichia coli O157:H7 str. Sakai 917777 NP_309062.1 CDS ECs1035 NC_002695.1 1142730 1144370 D similar to PQIB_ECOLI gi|1787184 (conserved in Escherichia coli K-12); paraquat-inducible protein B 1142730..1144370 Escherichia coli O157:H7 str. Sakai 917128 NP_309063.1 CDS ECs1036 NC_002695.1 1144382 1144930 D similar to YMBA_ECOLI gi|1787185 (conserved in Escherichia coli K-12); hypothetical protein 1144382..1144930 Escherichia coli O157:H7 str. Sakai 917129 NP_309064.1 CDS ECs1037 NC_002695.1 1145186 1145353 D similar to RMF_ECOLI gi|1787186 (conserved in Escherichia coli K-12); ribosome modulation factor 1145186..1145353 Escherichia coli O157:H7 str. Sakai 913590 NP_309065.1 CDS ECs1038 NC_002695.1 1145423 1145941 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase complement(1145423..1145941) Escherichia coli O157:H7 str. Sakai 917125 NP_309066.1 CDS ECs1039 NC_002695.1 1146010 1147770 R similar to B0955_ECOLI gi|1787188 (conserved in Escherichia coli K-12); ATP-dependent protease complement(1146010..1147770) Escherichia coli O157:H7 str. Sakai 917130 NP_309067.1 CDS ECs1040 NC_002695.1 1147956 1148408 D similar to YCBG_ECOLI gi|1787190 (conserved in Escherichia coli K-12); hypothetical protein 1147956..1148408 Escherichia coli O157:H7 str. Sakai 916914 NP_309068.1 CDS ECs1041 NC_002695.1 1148484 1149524 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A complement(1148484..1149524) Escherichia coli O157:H7 str. Sakai 917123 NP_309069.1 CDS ECs1042 NC_002695.1 1149881 1150390 R similar to SULA_ECOLI gi|1787192 (conserved in Escherichia coli K-12); SOS cell division inhibitor complement(1149881..1150390) Escherichia coli O157:H7 str. Sakai 916918 NP_309070.1 CDS ECs1043 NC_002695.1 1150609 1151238 D similar to B0959_ECOLI gi|1787193 (conserved in Escherichia coli K-12); hypothetical protein 1150609..1151238 Escherichia coli O157:H7 str. Sakai 914173 NP_309071.1 CDS ECs1044 NC_002695.1 1151201 1153363 R similar to B0960_ECOLI gi|1787194 (conserved in Escherichia coli K-12); hypothetical protein complement(1151201..1153363) Escherichia coli O157:H7 str. Sakai 917114 NP_309072.1 CDS ECs1045 NC_002695.1 1153373 1153819 R similar to YCCF_ECOLI gi|1787195 (conserved in Escherichia coli K-12); hypothetical protein complement(1153373..1153819) Escherichia coli O157:H7 str. Sakai 912728 NP_309073.1 CDS helD NC_002695.1 1153942 1155996 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1153942..1155996 Escherichia coli O157:H7 str. Sakai 913997 NP_309074.2 CDS mgsA NC_002695.1 1156028 1156486 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1156028..1156486) Escherichia coli O157:H7 str. Sakai 915175 NP_309075.1 CDS ECs1048 NC_002695.1 1156582 1157244 R similar to B0964_ECOLI gi|1787198 (conserved in Escherichia coli K-12); hypothetical protein complement(1156582..1157244) Escherichia coli O157:H7 str. Sakai 912544 NP_309076.1 CDS ECs1049 NC_002695.1 1157417 1157830 D similar to B0965_ECOLI gi|1787199 (conserved in Escherichia coli K-12); hypothetical protein 1157417..1157830 Escherichia coli O157:H7 str. Sakai 913587 NP_309077.2 CDS ECs1050 NC_002695.1 1157875 1158192 R similar to YCCV_ECOLI gi|1787200 (conserved in Escherichia coli K-12); heat shock protein HspQ complement(1157875..1158192) Escherichia coli O157:H7 str. Sakai 916125 NP_309078.2 CDS ECs1051 NC_002695.1 1158250 1159440 R similar to B0967_ECOLI gi|1787201 (conserved in Escherichia coli K-12); oxidoreductase complement(1158250..1159440) Escherichia coli O157:H7 str. Sakai 916915 NP_309079.1 CDS ECs1052 NC_002695.1 1159535 1159813 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1159535..1159813 Escherichia coli O157:H7 str. Sakai 916920 NP_309080.2 CDS ECs1053 NC_002695.1 1159810 1160139 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1159810..1160139) Escherichia coli O157:H7 str. Sakai 912999 NP_309081.1 CDS ECs1054 NC_002695.1 1160230 1160889 R similar to YCCA_ECOLI gi|1787205 (conserved in Escherichia coli K-12); hypothetical protein complement(1160230..1160889) Escherichia coli O157:H7 str. Sakai 912790 NP_309082.1 CDS ECs1055 NC_002695.1 1161297 1162316 R similar to integrase [Bacteriophage HK022] gi|138560|sp|P16407|VINT_BPHK0; integrase complement(1161297..1162316) Escherichia coli O157:H7 str. Sakai 912606 NP_309084.1 CDS ECs1057 NC_002695.1 1162604 1165075 R hypothetical protein complement(1162604..1165075) Escherichia coli O157:H7 str. Sakai 912439 NP_309085.1 CDS ECs1058 NC_002695.1 1165169 1165360 R similar to YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein complement(1165169..1165360) Escherichia coli O157:H7 str. Sakai 912451 NP_309086.1 CDS ECs1059 NC_002695.1 1165357 1165545 R similar to dicB [Escherichia coli] gi|2507009|sp|P09557|DICB_ECOLI; cell division inhibition protein complement(1165357..1165545) Escherichia coli O157:H7 str. Sakai 914198 NP_309087.1 CDS ECs1060 NC_002695.1 1165812 1166117 D hypothetical protein 1165812..1166117 Escherichia coli O157:H7 str. Sakai 912657 NP_309088.1 CDS ECs1061 NC_002695.1 1166119 1166304 D hypothetical protein 1166119..1166304 Escherichia coli O157:H7 str. Sakai 912568 NP_309090.1 CDS ECs1063 NC_002695.1 1166491 1166880 R hypothetical protein complement(1166491..1166880) Escherichia coli O157:H7 str. Sakai 912441 NP_309092.1 CDS ECs1065 NC_002695.1 1167022 1167177 R similar to YdfA [Escherichia coli] gi|140584|sp|P29008|YDFA_ECOLI; hypothetical protein complement(1167022..1167177) Escherichia coli O157:H7 str. Sakai 912966 NP_309094.1 CDS ECs1067 NC_002695.1 1167455 1167742 R similar to yacB [Plasmid ColIb-P9] gi|4512441|dbj|BAA75090.1; hypothetical protein complement(1167455..1167742) Escherichia coli O157:H7 str. Sakai 914057 NP_309095.1 CDS ECs1068 NC_002695.1 1167742 1167933 R hypothetical protein complement(1167742..1167933) Escherichia coli O157:H7 str. Sakai 912767 NP_309096.2 CDS ECs1069 NC_002695.1 1167961 1168362 R similar to probable regulatory protein [Salmonella typhimurium] gi|7467281|pir||T03008; similar toDicA [Escherichia coli] gi|118631|sp|P06966|DICA_ECOLI; regulatory protein complement(1167961..1168362) Escherichia coli O157:H7 str. Sakai 912951 NP_309097.1 CDS ECs1070 NC_002695.1 1168471 1168743 D hypothetical protein 1168471..1168743 Escherichia coli O157:H7 str. Sakai 912969 NP_309098.1 CDS ECs1071 NC_002695.1 1168727 1169152 D similar to YdaT [Escherichia coli] gi|3025103|sp|P76064|YDAT_ECOLI; hypothetical protein 1168727..1169152 Escherichia coli O157:H7 str. Sakai 913545 NP_309099.1 CDS ECs1072 NC_002695.1 1169359 1169814 R hypothetical protein complement(1169359..1169814) Escherichia coli O157:H7 str. Sakai 912987 NP_309100.1 CDS ECs1073 NC_002695.1 1169893 1170984 D hypothetical protein 1169893..1170984 Escherichia coli O157:H7 str. Sakai 913538 NP_309101.1 CDS ECs1074 NC_002695.1 1170991 1171737 D acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 1170991..1171737 Escherichia coli O157:H7 str. Sakai 912950 NP_309102.1 CDS ECs1075 NC_002695.1 1171759 1172529 D similar to gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein 1171759..1172529 Escherichia coli O157:H7 str. Sakai 912847 NP_309103.1 CDS ECs1076 NC_002695.1 1172545 1172958 D hypothetical protein 1172545..1172958 Escherichia coli O157:H7 str. Sakai 912746 NP_309104.1 CDS ECs1077 NC_002695.1 1173310 1174083 R similar to hypothetical proteins e.g. IroE [Salmonella enterica] gi|2738251|gb|AAC46182.1; hypothetical protein complement(1173310..1174083) Escherichia coli O157:H7 str. Sakai 912741 NP_309107.1 CDS ECs1080 NC_002695.1 1174631 1174843 D similar to Hok/Gef family e.g. MokW [Bacteriophage 933W] AAD25481.1; prophage maintenance protein 1174631..1174843 Escherichia coli O157:H7 str. Sakai 912864 NP_309108.1 CDS ECs1081 NC_002695.1 1175011 1175289 D similar to QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1; hypothetical protein 1175011..1175289 Escherichia coli O157:H7 str. Sakai 913001 NP_309109.2 CDS ECs1082 NC_002695.1 1175291 1176340 D hypothetical protein 1175291..1176340 Escherichia coli O157:H7 str. Sakai 914088 NP_309110.1 CDS ECs1083 NC_002695.1 1176353 1176724 D similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1; similar tocrossover junction endodeoxyribonuclease Rus [Escherichia coli cryptic prophage DLP12] gi|2; crossover junction endodeoxyribonuclease 1176353..1176724 Escherichia coli O157:H7 str. Sakai 912434 NP_309111.1 CDS ECs1084 NC_002695.1 1176714 1177085 D similar to bacteriophage antitermination proteins e.g. YbcQ [Escherichia coli cryptic prophage DLP12 gi|4585416|gb|AAD25444.1|AF125520_39; anti-termination protein 1176714..1177085 Escherichia coli O157:H7 str. Sakai 912786 NP_309112.1 CDS ECs1085 NC_002695.1 1177237 1178055 D similar to YpbD [Bacillus subtilis] gi|1730886|sp|P50730|YPBD_BACSU; hypothetical protein 1177237..1178055 Escherichia coli O157:H7 str. Sakai 912828 NP_309114.1 CDS ECs1087 NC_002695.1 1178802 1179389 D similar to transcriptional regulators e.g. YhiW [Escherichia coli] gi|586679|sp|P37638|YHIW_ECOLI; transcriptional regulator 1178802..1179389 Escherichia coli O157:H7 str. Sakai 912622 NP_309115.1 CDS ECs1088 NC_002695.1 1180157 1182007 D similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 1180157..1182007 Escherichia coli O157:H7 str. Sakai 912433 NP_309116.1 CDS ECs1089 NC_002695.1 1182183 1182509 D OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 1182183..1182509 Escherichia coli O157:H7 str. Sakai 914098 NP_309117.1 CDS ECs1090 NC_002695.1 1182506 1183159 D OrfB protein of insertion sequence IS629; similar to transposases e.g. [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 1182506..1183159 Escherichia coli O157:H7 str. Sakai 913026 NP_309119.1 CDS ECs1093 NC_002695.1 1184144 1184611 R similar to endopeptidases e.g. [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1; endopeptidase complement(1184144..1184611) Escherichia coli O157:H7 str. Sakai 913584 NP_309121.1 CDS ECs1094 NC_002695.1 1184613 1184726 R hypothetical protein complement(1184613..1184726) Escherichia coli O157:H7 str. Sakai 912537 NP_309123.1 CDS ECs1096 NC_002695.1 1184947 1185480 R similar to endolysins e.g. [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1; endolysin complement(1184947..1185480) Escherichia coli O157:H7 str. Sakai 913013 NP_309124.1 CDS ECs1098 NC_002695.1 1185513 1185707 R hypothetical protein complement(1185513..1185707) Escherichia coli O157:H7 str. Sakai 912554 NP_309125.1 CDS ECs1097 NC_002695.1 1185676 1185912 D hypothetical protein 1185676..1185912 Escherichia coli O157:H7 str. Sakai 912597 NP_309126.1 CDS ECs1099 NC_002695.1 1185861 1186205 D hypothetical protein 1185861..1186205 Escherichia coli O157:H7 str. Sakai 917142 NP_309127.1 CDS ECs1100 NC_002695.1 1186168 1186374 R similar to holin [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1; holin complement(1186168..1186374) Escherichia coli O157:H7 str. Sakai 912580 NP_309128.1 CDS ECs1101 NC_002695.1 1187125 1187400 D hypothetical protein 1187125..1187400 Escherichia coli O157:H7 str. Sakai 913754 NP_309129.1 CDS ECs1102 NC_002695.1 1187476 1187856 D similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1; hypothetical protein 1187476..1187856 Escherichia coli O157:H7 str. Sakai 913905 NP_309130.1 CDS ECs1103 NC_002695.1 1187853 1188200 D similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933] gi|3414882|gb|AAC31493.1; hypothetical protein 1187853..1188200 Escherichia coli O157:H7 str. Sakai 912945 NP_309131.1 CDS ECs1104 NC_002695.1 1188250 1189788 D similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1; hypothetical protein 1188250..1189788 Escherichia coli O157:H7 str. Sakai 912757 NP_309133.1 CDS ECs1106 NC_002695.1 1190052 1191980 D similar to terminase large subunit [Bacteriophage 21] gi|2851579|sp|P36693|TERL_BPP21; terminase large subunit 1190052..1191980 Escherichia coli O157:H7 str. Sakai 913831 NP_944588.1 CDS ECs5406 NC_002695.1 1191964 1192170 D hypothetical protein 1191964..1192170 Escherichia coli O157:H7 str. Sakai 2693815 NP_309134.1 CDS ECs1107 NC_002695.1 1192167 1193759 D similar to portal proteins e.g. GP4 [Bacteriophage P21] gi|549295|sp|P36272|VG04_BPP21; portal protein 1192167..1193759 Escherichia coli O157:H7 str. Sakai 912594 NP_309135.1 CDS ECs1108 NC_002695.1 1193749 1195254 D similar to head-tail preconnector proteins e.g. Gp5 [Bacteriophage P21] gi|549296|sp|P36273|VG05_BPP21; head-tail preconnector protein 1193749..1195254 Escherichia coli O157:H7 str. Sakai 912656 NP_309136.1 CDS ECs1109 NC_002695.1 1195291 1195638 D similar to head decoration proteins e.g. Gpshp [Bacteriophage P21] gi|549437|sp|P36275|VSHP_BPP21; head decoration protein 1195291..1195638 Escherichia coli O157:H7 str. Sakai 912349 NP_309137.1 CDS ECs1110 NC_002695.1 1195696 1195962 D similar to N-terminal parts of major head proteins e.g. Gp7 [Bacteriophage P21] gi|547612|sp|P36270|HEAD_BPP21; major head protein 1195696..1195962 Escherichia coli O157:H7 str. Sakai 915170 NP_309138.1 CDS ECs1111 NC_002695.1 1196079 1196684 D hypothetical protein 1196079..1196684 Escherichia coli O157:H7 str. Sakai 912499 NP_309139.2 CDS ECs1112 NC_002695.1 1196698 1197129 D similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 1196698..1197129 Escherichia coli O157:H7 str. Sakai 915165 NP_309140.1 CDS ECs1113 NC_002695.1 1197180 1197569 D similar to minor tail proteins GpG-T [Bacteriophage lambda] gi|7429179|pir||TLBPTL; probably produced by translational frameshift; minor tail protein 1197180..1197569 Escherichia coli O157:H7 str. Sakai 912414 NP_309141.1 CDS ECs1114 NC_002695.1 1197550 1200129 D tail length determinator; similar to tail length tape measure proteins e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 1197550..1200129 Escherichia coli O157:H7 str. Sakai 915164 NP_309142.1 CDS ECs1115 NC_002695.1 1200126 1200455 D similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1200126..1200455 Escherichia coli O157:H7 str. Sakai 912914 NP_309143.1 CDS ECs1116 NC_002695.1 1200455 1201153 D similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1200455..1201153 Escherichia coli O157:H7 str. Sakai 912440 NP_309144.1 CDS ECs1117 NC_002695.1 1201272 1201907 D similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 1201272..1201907 Escherichia coli O157:H7 str. Sakai 912587 NP_309145.1 CDS ECs1118 NC_002695.1 1201805 1202485 D similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1201805..1202485 Escherichia coli O157:H7 str. Sakai 912997 NP_309146.1 CDS ECs1119 NC_002695.1 1202439 1202645 D hypothetical protein 1202439..1202645 Escherichia coli O157:H7 str. Sakai 912655 NP_309147.1 CDS ECs1120 NC_002695.1 1202676 1203203 R similar to copper/zinc-superoxide dismutases e.g. [Salmonella typhimurium] gi|2462699|emb|CAA73588.1; copper/zinc-superoxide dismutase complement(1202676..1203203) Escherichia coli O157:H7 str. Sakai 912575 NP_309148.1 CDS ECs1121 NC_002695.1 1203337 1206810 D similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1203337..1206810 Escherichia coli O157:H7 str. Sakai 912880 NP_309149.1 CDS ECs1122 NC_002695.1 1206878 1207477 D similar to Lom outer membrane proteins e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein 1206878..1207477 Escherichia coli O157:H7 str. Sakai 914035 NP_309150.1 CDS ECs1123 NC_002695.1 1207536 1208855 D similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 1207536..1208855 Escherichia coli O157:H7 str. Sakai 912411 NP_309151.1 CDS ECs1124 NC_002695.1 1208857 1209126 D similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; similar to tail protein of 933W gi|4585436|gb|AAD25464.1|AF125520_59; hypothetical protein 1208857..1209126 Escherichia coli O157:H7 str. Sakai 912563 NP_309152.1 CDS ECs1126 NC_002695.1 1209251 1209820 R probable secreted effector protein; similar to EspF proteins e.g. [Escherichia coli strain E2348/69] gi|2865308|gb|AAC38400.1; similar toL0016 - Escherichia coli gi|3414884|gb|AAC31495.1; EspF-like protein complement(1209251..1209820) Escherichia coli O157:H7 str. Sakai 915162 NP_309153.1 CDS ECs1125 NC_002695.1 1209796 1209978 D hypothetical protein 1209796..1209978 Escherichia coli O157:H7 str. Sakai 915169 NP_309154.1 CDS ECs1127 NC_002695.1 1210459 1210641 R similar to avirulence protein A [Pseudomonas syringae] gi|114726|sp|P11437|AVRA_PSESG; hypothetical protein complement(1210459..1210641) Escherichia coli O157:H7 str. Sakai 912464 NP_309155.1 CDS ECs1128 NC_002695.1 1211259 1212377 D similar to HYAA_ECOLI gi|1787206 (conserved in Escherichia coli K-12); hydrogenase-1 small subunit 1211259..1212377 Escherichia coli O157:H7 str. Sakai 912588 NP_309156.1 CDS ECs1129 NC_002695.1 1212374 1214167 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1212374..1214167 Escherichia coli O157:H7 str. Sakai 912492 NP_309157.1 CDS ECs1130 NC_002695.1 1214186 1214893 D similar to HYAC_ECOLI gi|1787208 (conserved in Escherichia coli K-12); hydrogenase 1 b-type cytochrome subunit 1214186..1214893 Escherichia coli O157:H7 str. Sakai 912637 NP_309158.1 CDS ECs1131 NC_002695.1 1214890 1215477 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1214890..1215477 Escherichia coli O157:H7 str. Sakai 912497 NP_309159.1 CDS ECs1132 NC_002695.1 1215474 1215872 D involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1215474..1215872 Escherichia coli O157:H7 str. Sakai 912590 NP_309160.1 CDS ECs1133 NC_002695.1 1215869 1216726 D similar to HYAF_ECOLI gi|1787211 (conserved in Escherichia coli K-12); hydrogenase-1 operon protein HyaF 1215869..1216726 Escherichia coli O157:H7 str. Sakai 914195 NP_309161.1 CDS ECs1134 NC_002695.1 1216860 1218404 D similar to APPC_ECOLI gi|1787212 (conserved in Escherichia coli K-12); third cytochrome oxidase subunit I 1216860..1218404 Escherichia coli O157:H7 str. Sakai 912583 NP_309162.1 CDS ECs1135 NC_002695.1 1218416 1219552 D similar to APPB_ECOLI gi|1787213 (conserved in Escherichia coli K-12); third cytochrome oxidase subunit II 1218416..1219552 Escherichia coli O157:H7 str. Sakai 912596 NP_309163.1 CDS ECs1136 NC_002695.1 1219737 1221041 D similar to phosphoanhydride phosphorylase APPA_ECOLI gi|1787215 (conserved in Escherichia coli K-12); phosphoanhydride phosphorylase 1219737..1221041 Escherichia coli O157:H7 str. Sakai 912585 NP_309164.1 CDS ECs1137 NC_002695.1 1221161 1223341 R similar to YCCC_ECOLI gi|1787216 (conserved in Escherichia coli K-12); cryptic autophosphorylating protein tyrosine kinase Etk complement(1221161..1223341) Escherichia coli O157:H7 str. Sakai 912586 NP_309165.2 CDS etp NC_002695.1 1223361 1223807 R Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase complement(1223361..1223807) Escherichia coli O157:H7 str. Sakai 914076 NP_309166.1 CDS ECs1139 NC_002695.1 1223795 1224934 R function in exopolysaccharide production; similar to YCCZ_ECOLI gi|1787218 (conserved in Escherichia coli K-12); hypothetical protein complement(1223795..1224934) Escherichia coli O157:H7 str. Sakai 915179 NP_309167.1 CDS ECs1140 NC_002695.1 1224980 1227076 R similar to YMCA_ECOLI gi|1787219 (conserved in Escherichia coli K-12); hypothetical protein complement(1224980..1227076) Escherichia coli O157:H7 str. Sakai 912530 NP_309168.1 CDS ECs1141 NC_002695.1 1227076 1227822 R similar to YMCB_ECOLI gi|1787220 (conserved in Escherichia coli K-12); hypothetical protein complement(1227076..1227822) Escherichia coli O157:H7 str. Sakai 914107 NP_309169.1 CDS ECs1142 NC_002695.1 1227819 1228463 R similar to YMCC_ECOLI gi|1787221 (conserved in Escherichia coli K-12); regulator complement(1227819..1228463) Escherichia coli O157:H7 str. Sakai 913925 NP_309170.1 CDS ECs1143 NC_002695.1 1228570 1228893 R similar to YMCD_ECOLI gi|1787222 (conserved in Escherichia coli K-12); hypothetical protein complement(1228570..1228893) Escherichia coli O157:H7 str. Sakai 912571 NP_309171.1 CDS ECs1144 NC_002695.1 1229317 1229529 R similar to CSPH_ECOLI gi|2367112 (conserved in Escherichia coli K-12); cold shock-like protein complement(1229317..1229529) Escherichia coli O157:H7 str. Sakai 912600 NP_309172.1 CDS ECs1145 NC_002695.1 1229815 1230027 D similar to CSPG_ECOLI gi|2367114 (conserved in Escherichia coli K-12); cold shock protein CspG 1229815..1230027 Escherichia coli O157:H7 str. Sakai 912577 NP_309173.1 CDS ECs1146 NC_002695.1 1230201 1230431 D similar to SFA_ECOLI gi|1787225 (conserved in Escherichia coli K-12); cold shock gene 1230201..1230431 Escherichia coli O157:H7 str. Sakai 913646 NP_309174.1 CDS ECs1147 NC_002695.1 1230642 1231715 R similar to YCCM_ECOLI gi|1787226 (conserved in Escherichia coli K-12); hypothetical protein complement(1230642..1231715) Escherichia coli O157:H7 str. Sakai 913544 NP_309175.2 CDS ECs1148 NC_002695.1 1231787 1234531 R Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS complement(1231787..1234531) Escherichia coli O157:H7 str. Sakai 913641 NP_309176.1 CDS ECs1149 NC_002695.1 1234614 1235642 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1234614..1235642 Escherichia coli O157:H7 str. Sakai 913730 NP_309177.1 CDS ECs1150 NC_002695.1 1235615 1236307 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1235615..1236307) Escherichia coli O157:H7 str. Sakai 914140 NP_309178.1 CDS ECs1151 NC_002695.1 1236437 1237609 D similar to TORC_ECOLI gi|1787230 (conserved in Escherichia coli K-12); trimethylamine N-oxide reductase cytochrome c-type subunit 1236437..1237609 Escherichia coli O157:H7 str. Sakai 912595 NP_309179.1 CDS ECs1152 NC_002695.1 1237609 1240155 D similar to TORA_ECOLI gi|1787231 (conserved in Escherichia coli K-12); trimethylamine N-oxide reductase subunit 1237609..1240155 Escherichia coli O157:H7 str. Sakai 913030 NP_309180.1 CDS torD NC_002695.1 1240152 1240751 D TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1240152..1240751 Escherichia coli O157:H7 str. Sakai 912584 NP_309181.1 CDS ECs1154 NC_002695.1 1240905 1241210 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1240905..1241210) Escherichia coli O157:H7 str. Sakai 915178 NP_309182.1 CDS ECs1155 NC_002695.1 1241210 1242130 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1241210..1242130) Escherichia coli O157:H7 str. Sakai 913525 NP_309185.1 CDS ECs1158 NC_002695.1 1243938 1245179 D similar to AGP_ECOLI gi|1787237 (conserved in Escherichia coli K-12); glucose-1-phosphatase/inositol phosphatase 1243938..1245179 Escherichia coli O157:H7 str. Sakai 913790 NP_309186.1 CDS ECs1159 NC_002695.1 1245217 1245444 R similar to YCCJ_ECOLI gi|1787238 (conserved in Escherichia coli K-12); hypothetical protein complement(1245217..1245444) Escherichia coli O157:H7 str. Sakai 913848 YP_004935383.1 CDS wrbA NC_002695.1 1245465 1246010 R TrpR binding protein WrbA complement(1245465..1246010) Escherichia coli O157:H7 str. Sakai 11451195 NP_309187.1 CDS ECs1160 NC_002695.1 1246040 1247350 R similar to integrase [Bacteriophage 933W] gi|4585378|gb|AAD25406.1|AF125520_1 and [Escherichia coli rac prophage] gi|6166234|sp|P76056|INTR_ECOLI; integrase complement(1246040..1247350) Escherichia coli O157:H7 str. Sakai 912564 NP_309188.1 CDS ECs1161 NC_002695.1 1247403 1247687 R similar to excisionase [Bacteriophage 933W] gi|4585379|gb|AAD25407.1|AF125520_2; excisionase complement(1247403..1247687) Escherichia coli O157:H7 str. Sakai 912465 NP_309189.1 CDS ECs1162 NC_002695.1 1247773 1248084 R similar to hypothetical protein [Bacteriophage 933W] gi|4585380|gb|AAD25408.1|AF125520_3; hypothetical protein complement(1247773..1248084) Escherichia coli O157:H7 str. Sakai 912355 NP_309190.1 CDS ECs1163 NC_002695.1 1248144 1248488 R similar to hypothetical protein [Bacteriophage 933W] gi|4585381|gb|AAD25409.1|AF125520_4; hypothetical protein complement(1248144..1248488) Escherichia coli O157:H7 str. Sakai 912616 NP_309191.1 CDS ECs1164 NC_002695.1 1248421 1249044 R similar to hypothetical protein [Bacteriophage 933W] gi|4585382|gb|AAD25410.1|AF125520_5; similar to hypothetical protein [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein complement(1248421..1249044) Escherichia coli O157:H7 str. Sakai 912910 NP_309192.1 CDS ECs1165 NC_002695.1 1249048 1249335 R similar to hypothetical protein [Bacteriophage 933W] gi|4585383|gb|AAD25411.1|AF125520_6; hypothetical protein complement(1249048..1249335) Escherichia coli O157:H7 str. Sakai 912740 NP_309193.1 CDS ECs1166 NC_002695.1 1249337 1249555 R similar to hypothetical protein [Bacteriophage 933W] gi|4585384|gb|AAD25412.1|AF125520_7; hypothetical protein complement(1249337..1249555) Escherichia coli O157:H7 str. Sakai 915194 NP_309194.1 CDS ECs1167 NC_002695.1 1249557 1249844 R similar to hypothetical protein [Bacteriophage 933W] gi|4585385|gb|AAD25413.1|AF125520_8; hypothetical protein complement(1249557..1249844) Escherichia coli O157:H7 str. Sakai 913027 NP_309195.1 CDS ECs1168 NC_002695.1 1249774 1250241 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881600|dbj|BAA84291.1; hypothetical protein complement(1249774..1250241) Escherichia coli O157:H7 str. Sakai 912386 NP_309196.1 CDS ECs1169 NC_002695.1 1250114 1250887 R similar to hypothetical protein [Bacteriophage 933W] gi|4585386|gb|AAD25414.1|AF125520_9, similar to hypothetical protein [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein complement(1250114..1250887) Escherichia coli O157:H7 str. Sakai 913040 NP_309197.1 CDS ECs1170 NC_002695.1 1250884 1251105 R similar to C4-type zinc finger proteins (TraR family) e.g. gi|4585456|gb|AAD25484.1|AF125520_79; C4-type zinc finger TraR complement(1250884..1251105) Escherichia coli O157:H7 str. Sakai 913822 NP_309198.1 CDS ECs1171 NC_002695.1 1251204 1251419 R similar to hypothetical protein [Bacteriophage 933W]; similar to orf61 [Bacteriophage lambda] gi|508993|gb|AAA96566.1; hypothetical protein complement(1251204..1251419) Escherichia coli O157:H7 str. Sakai 912986 NP_309199.1 CDS ECs1172 NC_002695.1 1251496 1251687 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881603|dbj|BAA84294.1|, similar to orf63 [Bacteriophage lambda] gi|508994|gb|AAA96567.1; hypothetical protein complement(1251496..1251687) Escherichia coli O157:H7 str. Sakai 914108 NP_309200.1 CDS ECs1173 NC_002695.1 1251660 1251842 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881604|dbj|BAA84295.1, similar to orf60a [Bacteriophage lambda] gi|508995|gb|AAA96568.1; hypothetical protein complement(1251660..1251842) Escherichia coli O157:H7 str. Sakai 912448 NP_309201.1 CDS ECs1174 NC_002695.1 1251839 1252519 R similar to exonuclease [Bacteriophage lambda] gi|2981722|pdb|1AVQ|A; exonuclease complement(1251839..1252519) Escherichia coli O157:H7 str. Sakai 912450 NP_309202.1 CDS ECs1175 NC_002695.1 1252516 1253301 R similar to Bet [Bacteriophage VT2-Sa] gi|5881606|dbj|BAA84297.1 and [Bacteriophage lambda] gi|137511|sp|P03698|VBET_LAMBD; recombination protein Bet complement(1252516..1253301) Escherichia coli O157:H7 str. Sakai 913518 NP_309203.1 CDS ECs1176 NC_002695.1 1253307 1253723 R host-nuclease inhibitor protein; similar to Gam protein [Bacteriophage lambda] gi|138128|sp|P03702|VGAM_LAMBD; hypothetical protein complement(1253307..1253723) Escherichia coli O157:H7 str. Sakai 913719 NP_309204.1 CDS ECs1177 NC_002695.1 1253678 1253947 R similar to kil [Bacteriophage VT2-Sa] gi|5881608|dbj|BAA84299.1 and [Bacteriophage lambda] gi|138622|sp|P03758|VKIL_LAMBD; Kil protein complement(1253678..1253947) Escherichia coli O157:H7 str. Sakai 912898 NP_309205.1 CDS ECs1178 NC_002695.1 1253790 1253954 R antitermination; similar to cIII [Bacteriophage lambda] gi|133366|sp|P03044|RPC3_LAMBD; regulatory protein cIII complement(1253790..1253954) Escherichia coli O157:H7 str. Sakai 912643 NP_309206.1 CDS ECs1179 NC_002695.1 1254027 1254395 R single strand binding protein; similar to Ea10 [Bacteriophage VT2-Sa] gi|5881610|dbj|BAA84301.1 and [Bacteriophage lambda] gi|137630|sp|P03757|VE10_LAMBD; hypothetical protein complement(1254027..1254395) Escherichia coli O157:H7 str. Sakai 912933 NP_309207.1 CDS ECs1180 NC_002695.1 1254578 1254829 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881612|dbj|BAA84303.1; hypothetical protein complement(1254578..1254829) Escherichia coli O157:H7 str. Sakai 913005 NP_309208.1 CDS ECs1181 NC_002695.1 1254888 1255160 R similar to N protein [Bacteriophage VT2-Sa] gi|5881613|dbj|BAA84304.1 and [Bacteriophage 933W] gi|4585397|gb|AAD25425.1|AF125520_20; hypothetical protein complement(1254888..1255160) Escherichia coli O157:H7 str. Sakai 914151 NP_309209.1 CDS ECs1182 NC_002695.1 1255138 1255320 R hypothetical protein complement(1255138..1255320) Escherichia coli O157:H7 str. Sakai 912920 NP_309210.1 CDS ECs1183 NC_002695.1 1255617 1255778 D hypothetical protein 1255617..1255778 Escherichia coli O157:H7 str. Sakai 912491 NP_309211.1 CDS ECs1184 NC_002695.1 1255889 1256410 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881614|dbj|BAA84305.1; hypothetical protein complement(1255889..1256410) Escherichia coli O157:H7 str. Sakai 912589 NP_309212.1 CDS ECs1185 NC_002695.1 1256912 1257565 R similar to cI [Bacteriophage lambda] gi|133353|sp|P03034|RPC1_LAMBD; cI repressor protein complement(1256912..1257565) Escherichia coli O157:H7 str. Sakai 912404 NP_309213.1 CDS ECs1186 NC_002695.1 1257683 1257898 D probable regulatory protein, similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881616|dbj|BAA84307.1 and c2 [Bacteriophage L] gi|1469215|emb|CAA63999.1; CRO 1257683..1257898 Escherichia coli O157:H7 str. Sakai 912935 NP_309214.1 CDS ECs1187 NC_002695.1 1258040 1258336 D regulatory protein; similar to CII [Bacteriophage VT2-Sa] gi|5881617|dbj|BAA84308.1 and [Enterobacteria phage HK022] gi|631957|pir||S42398; hypothetical protein 1258040..1258336 Escherichia coli O157:H7 str. Sakai 914205 NP_309215.1 CDS ECs1188 NC_002695.1 1258369 1258515 D similar to hypothetical protein [Enterobacteria phage HK022] gi|632160|pir||S42399, orf48 [Bacteriophage P22] gi|871503|emb|CAA55155.1; hypothetical protein 1258369..1258515 Escherichia coli O157:H7 str. Sakai 913718 NP_309216.1 CDS ECs1189 NC_002695.1 1258508 1259407 D similar to O proteins e.g. O [Enterobacteria phage HK022] gi|407289|gb|AAB60272.1; replication protein O 1258508..1259407 Escherichia coli O157:H7 str. Sakai 912502 NP_309217.1 CDS ECs1190 NC_002695.1 1259382 1260833 D replicative DNA helicase; similar to P protein [Enterobacteria phage HK022] gi|6863143|gb|AAF30384.1|AF069308_32, replicative DNA helicase DnaB [Escherichia col; replication protein P 1259382..1260833 Escherichia coli O157:H7 str. Sakai 912972 NP_309218.1 CDS ECs1191 NC_002695.1 1260833 1261102 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881620|dbj|BAA84311.1; hypothetical protein 1260833..1261102 Escherichia coli O157:H7 str. Sakai 914143 NP_309219.1 CDS ECs1192 NC_002695.1 1261173 1261451 D similar to hypothetical protein [Bacteriophage 933W] gi|4499788|emb|CAB39287.1; hypothetical protein 1261173..1261451 Escherichia coli O157:H7 str. Sakai 912446 NP_309220.1 CDS ECs1193 NC_002695.1 1261584 1261799 D similar to hypothetical protein [Bacteriophage 933W] gi|4499789|emb|CAB39288.1; hypothetical protein 1261584..1261799 Escherichia coli O157:H7 str. Sakai 913833 NP_309221.1 CDS ECs1194 NC_002695.1 1261810 1262046 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881622|dbj|BAA84313.1 and [Bacteriophage 933W] gi|4499790|emb|CAB39289.1; hypothetical protein 1261810..1262046 Escherichia coli O157:H7 str. Sakai 914070 NP_309222.1 CDS ECs1195 NC_002695.1 1262003 1262449 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881623|dbj|BAA84314.1 and NinB protein [Bacteriophage 21]; hypothetical protein 1262003..1262449 Escherichia coli O157:H7 str. Sakai 912513 NP_309223.1 CDS ECs1196 NC_002695.1 1262446 1262973 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881624|dbj|BAA84315.1 and Gp62 [Bacteriophage HK97] gi|6901634|gb|AAF31137.1; DNA methylase 1262446..1262973 Escherichia coli O157:H7 str. Sakai 913996 NP_309224.1 CDS ECs1197 NC_002695.1 1262970 1263152 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881625|dbj|BAA84316.1 and NinE protein [Bacteriophage 21] gi|4539480|emb|CAB39989.1; protein NinE 1262970..1263152 Escherichia coli O157:H7 str. Sakai 913015 NP_309226.1 CDS ECs1199 NC_002695.1 1263427 1264161 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881627|dbj|BAA84318.1 and antirepressor protein Ant [Bacteriophage P22]; antirepressor protein 1263427..1264161 Escherichia coli O157:H7 str. Sakai 913580 NP_309227.1 CDS ECs1200 NC_002695.1 1264236 1264958 D similar to Roi [Bacteriophage VT2-Sa] gi|5881628|dbj|BAA84319.1 and Roi proteins e.g. [Enterobacteria phage HK022] gi|1197729|gb|AAC48863.1; DNA-binding protein 1264236..1264958 Escherichia coli O157:H7 str. Sakai 913662 NP_309228.1 CDS ECs1201 NC_002695.1 1264958 1265563 D similar to hypothetical protein orf15 [Bacteriophage 933W] gi|4499798|emb|CAB39297.1 and NinG protein [Bacteriophage 21] gi|4539482|emb|CAB39991.1; protein NinG 1264958..1265563 Escherichia coli O157:H7 str. Sakai 912371 NP_309229.1 CDS ECs1202 NC_002695.1 1265560 1265754 D similar to hypothetical protein orf16 [Bacteriophage 933W] gi|4499799|emb|CAB39298.1 and hypothetical proteins e.g. Nin68 [Bacteriophage lambda] gi|9626304|ref|NP_040640.1; hypothetical protein 1265560..1265754 Escherichia coli O157:H7 str. Sakai 912456 NP_309230.1 CDS ECs1203 NC_002695.1 1265747 1266181 D similar to antitermination protein Q [Bacteriophage 933W] gi|4585416|gb|AAD25444.1|AF125520_39 and antitermination Q proteins e.g. [Bacteriophage H-19B] gi|2668768|gb|AAD04655.1; antitermination protein Q 1265747..1266181 Escherichia coli O157:H7 str. Sakai 913671 NP_309231.1 CDS ECs1204 NC_002695.1 1266430 1266582 D similar to hypothetical protein [Bacteriophage P27] gi|8346570|emb|CAB93763.1|; hypothetical protein 1266430..1266582 Escherichia coli O157:H7 str. Sakai 912801 NP_309232.1 CDS ECs1205 NC_002695.1 1266965 1267924 D similar to gi|1351074|sp|P09385|SLTA_BP933; Shiga toxin 2 subunit A 1266965..1267924 Escherichia coli O157:H7 str. Sakai 912807 NP_309233.1 CDS ECs1206 NC_002695.1 1267936 1268205 D similar to gi|134538|sp|P09386|SLTB_BP933; Shiga toxin 2 subunit B 1267936..1268205 Escherichia coli O157:H7 str. Sakai 912579 NP_309234.1 CDS ECs1207 NC_002695.1 1268692 1270596 D similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42 and YjhS [Shigella dysenteriae] gi|6759965|gb|; hypothetical protein 1268692..1270596 Escherichia coli O157:H7 str. Sakai 912907 NP_309235.1 CDS ECs1208 NC_002695.1 1270403 1271293 R OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase complement(1270403..1271293) Escherichia coli O157:H7 str. Sakai 914040 NP_309236.1 CDS ECs1209 NC_002695.1 1271290 1271616 R OrfA protein of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase complement(1271290..1271616) Escherichia coli O157:H7 str. Sakai 912762 NP_309237.1 CDS ECs1210 NC_002695.1 1272078 1272257 D similar to hypothetical protein [Bacteriophage 933W] gi|4499806|emb|CAB39305.1; hypothetical protein 1272078..1272257 Escherichia coli O157:H7 str. Sakai 912298 NP_309238.2 CDS ECs1211 NC_002695.1 1272298 1272570 D similar to hypothetical protein [Bacteriophage 933W] gi|4585420|gb|AAD25448.1|AF125520_43; hypothetical protein 1272298..1272570 Escherichia coli O157:H7 str. Sakai 912967 NP_309239.1 CDS ECs1212 NC_002695.1 1272647 1272862 D similar to protein S [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1 and [Shigella dysenteriae] gi|6759967|gb|AAF28125.1|AF153317_21; holin 1272647..1272862 Escherichia coli O157:H7 str. Sakai 913732 NP_309240.1 CDS ECs1213 NC_002695.1 1272867 1273400 D similar to endolysin [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45 and endolysins e.g. [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1; endolysin 1272867..1273400 Escherichia coli O157:H7 str. Sakai 913680 NP_309241.1 CDS ECs1214 NC_002695.1 1273671 1274240 D similar to antirepressor protein [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46 and antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1273671..1274240 Escherichia coli O157:H7 str. Sakai 912535 NP_309242.1 CDS ECs1215 NC_002695.1 1274394 1274858 D similar to endopeptidase [Bacteriophage 933W] gi|4585424|gb|AAD25452.1|AF125520_47 and Rz [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 1274394..1274858 Escherichia coli O157:H7 str. Sakai 912904 NP_309244.1 CDS ECs1217 NC_002695.1 1274890 1275183 R similar to [Bacteriophage 933W] gi|4585426|gb|AAD25454.1|AF125520_49 and Bor protein precursor [Bacteriophage lambda] gi|137520|sp|P26814|VBOR_LAMBD; Bor protein complement(1274890..1275183) Escherichia coli O157:H7 str. Sakai 913557 NP_309245.2 CDS ECs1218 NC_002695.1 1275291 1275536 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881640|dbj|BAA84331.1; hypothetical protein 1275291..1275536 Escherichia coli O157:H7 str. Sakai 913530 NP_309246.1 CDS ECs1219 NC_002695.1 1275592 1276398 D similar to small subunit terminase [Bacteriophage 933W] gi|4585427|gb|AAD25455.1|AF125520_50; small subunit terminase 1275592..1276398 Escherichia coli O157:H7 str. Sakai 912647 NP_309247.1 CDS ECs1220 NC_002695.1 1276379 1278085 D similar to terminase large subunit [Bacteriophage 933W] gi|4585428|gb|AAD25456.1|AF125520_51; terminase large subunit 1276379..1278085 Escherichia coli O157:H7 str. Sakai 912871 NP_309248.1 CDS ECs1221 NC_002695.1 1278085 1280229 D similar to portal protein [Bacteriophage 933W] gi|4585429|gb|AAD25457.1|AF125520_52; portal protein 1278085..1280229 Escherichia coli O157:H7 str. Sakai 912727 NP_309249.1 CDS ECs1222 NC_002695.1 1280387 1281394 D similar to hypothetical protein [Bacteriophage 933W] gi|4585430|gb|AAD25458.1|AF125520_53; hypothetical protein 1280387..1281394 Escherichia coli O157:H7 str. Sakai 912459 NP_309250.1 CDS ECs1223 NC_002695.1 1281418 1282632 D similar to hypothetical protein [Bacteriophage 933W] gi|4585431|gb|AAD25459.1|AF125520_54; hypothetical protein 1281418..1282632 Escherichia coli O157:H7 str. Sakai 914220 NP_309251.1 CDS ECs1224 NC_002695.1 1282688 1283077 D similar to hypothetical protein [Bacteriophage 933W] gi|4585432|gb|AAD25460.1|AF125520_55; hypothetical protein 1282688..1283077 Escherichia coli O157:H7 str. Sakai 912617 NP_309252.1 CDS ECs1225 NC_002695.1 1283127 1283588 D similar to hypothetical protein [Bacteriophage 933W] gi|4585433|gb|AAD25461.1|AF125520_56; hypothetical protein 1283127..1283588 Escherichia coli O157:H7 str. Sakai 912613 NP_309253.1 CDS ECs1226 NC_002695.1 1283572 1284135 D similar to hypothetical protein [Bacteriophage 933W] gi|4585434|gb|AAD25462.1|AF125520_57; hypothetical protein 1283572..1284135 Escherichia coli O157:H7 str. Sakai 912959 NP_309254.1 CDS ECs1227 NC_002695.1 1284135 1284785 D similar to hypothetical protein [Bacteriophage 933W] gi|4585435|gb|AAD25463.1|AF125520_58; hypothetical protein 1284135..1284785 Escherichia coli O157:H7 str. Sakai 912471 NP_309255.1 CDS ECs1228 NC_002695.1 1284782 1286719 D similar to tail fiber protein [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 1284782..1286719 Escherichia coli O157:H7 str. Sakai 913841 NP_309256.1 CDS ECs1229 NC_002695.1 1286721 1286990 D similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 1286721..1286990 Escherichia coli O157:H7 str. Sakai 912963 NP_309257.1 CDS ECs1230 NC_002695.1 1287076 1287318 D similar to hypothetical protein [Bacteriophage 933W] gi|4585438|gb|AAD25466.1|AF125520_61; hypothetical protein 1287076..1287318 Escherichia coli O157:H7 str. Sakai 914028 NP_309258.1 CDS ECs1231 NC_002695.1 1287205 1287447 R outer membrane protein complement(1287205..1287447) Escherichia coli O157:H7 str. Sakai 912373 NP_309259.1 CDS ECs1232 NC_002695.1 1287535 1289238 D similar to hypothetical protein [Bacteriophage 933W] gi|4585439|gb|AAD25467.1|AF125520_62, [Bacteriophage P-EibD] gi|7523538|gb|AAF63043.1|AF151675_5; hypothetical protein 1287535..1289238 Escherichia coli O157:H7 str. Sakai 912738 NP_309260.1 CDS ECs1233 NC_002695.1 1289235 1290503 D similar to tail tip fiber protein gp21 [phage N15] gi|7444604|pir||T13107, [Bacteriophage 933W] gi|4585440|gb|AAD25468.1|AF125520_63; probable tail tip fiber protein; tail tip fiber protein 1289235..1290503 Escherichia coli O157:H7 str. Sakai 912610 NP_309261.1 CDS ECs1234 NC_002695.1 1290518 1290796 D similar to hypothetical protein [Bacteriophage 933W] gi|4585441|gb|AAD25469.1|AF125520_64; outer membrane protein 1290518..1290796 Escherichia coli O157:H7 str. Sakai 912632 NP_309262.1 CDS ECs1235 NC_002695.1 1290802 1291419 D similar to hypothetical protein [Bacteriophage 933W] gi|4585442|gb|AAD25470.1|AF125520_65; hypothetical protein 1290802..1291419 Escherichia coli O157:H7 str. Sakai 913928 NP_309263.1 CDS ECs1236 NC_002695.1 1291510 1292244 D similar to tail gene products e.g. [Yersinia pseudotuberculosis] gi|5902750|sp|Q56957|AIL_YERPS, outer membrane protein Lom precursor gi|138693|sp|P03701|VLOM_LAMBD, virulence protein pagC precursor [Salmonella typhimurium] gi|129558|sp|P23988|PAGC_SALTY, Lom precursor [Bacteriophage 933W] gi|4585443|gb|AAD25471.1|AF125520_66, outer membrane protein rck [Salmonella typhimurium] gi|282013|pir||A43309; outer membrane protein 1291510..1292244 Escherichia coli O157:H7 str. Sakai 914208 NP_309264.1 CDS ECs1237 NC_002695.1 1292674 1293075 D similar to hypothetical protein [Bacteriophage 933W] gi|4585444|gb|AAD25472.1|AF125520_67; hypothetical protein 1292674..1293075 Escherichia coli O157:H7 str. Sakai 912598 NP_309265.1 CDS ECs1238 NC_002695.1 1293169 1293825 D similar to hypothetical protein [Bacteriophage 933W] gi|4585445|gb|AAD25473.1|AF125520_68; hypothetical protein 1293169..1293825 Escherichia coli O157:H7 str. Sakai 912494 NP_309266.1 CDS ECs1239 NC_002695.1 1293828 1294274 D similar to hypothetical protein [Bacteriophage 933W] gi|4585446|gb|AAD25474.1|AF125520_69; hypothetical protein 1293828..1294274 Escherichia coli O157:H7 str. Sakai 913010 NP_309267.1 CDS ECs1240 NC_002695.1 1294284 1294535 D similar to hypothetical protein [Bacteriophage 933W] gi|4585447|gb|AAD25475.1|AF125520_70; hypothetical protein 1294284..1294535 Escherichia coli O157:H7 str. Sakai 912772 NP_309268.1 CDS ECs1241 NC_002695.1 1294546 1295811 D similar to hypothetical protein [Bacteriophage 933W] gi|4585448|gb|AAD25476.1|AF125520_71; hypothetical protein 1294546..1295811 Escherichia coli O157:H7 str. Sakai 913004 NP_309269.1 CDS ECs1242 NC_002695.1 1295881 1304262 D similar to hypothetical protein [Bacteriophage 933W] gi|4585449|gb|AAD25477.1|AF125520_72; hypothetical protein 1295881..1304262 Escherichia coli O157:H7 str. Sakai 912529 NP_309270.1 CDS ECs1243 NC_002695.1 1304548 1304733 D similar to hypothetical protein [Bacteriophage 933W] gi|4585450|gb|AAD25478.1|AF125520_73; hypothetical protein 1304548..1304733 Escherichia coli O157:H7 str. Sakai 914152 NP_309271.1 CDS ECs1244 NC_002695.1 1304813 1305157 R similar to hypothetical protein [Bacteriophage 933W] gi|9632540|ref|NP_049534.1, ygiW protein precursor [Escherichia coli] gi|1723887|sp|P52083|YGIW_ECOLI; hypothetical protein complement(1304813..1305157) Escherichia coli O157:H7 str. Sakai 912897 NP_309272.1 CDS ECs1245 NC_002695.1 1305277 1305489 R similar to MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76, GelF [Escherichia coli] gi|1786200|gb|AAC73129.1; MokW protein complement(1305277..1305489) Escherichia coli O157:H7 str. Sakai 913002 NP_309273.1 CDS ECs1246 NC_002695.1 1305723 1306118 R similar to hypothetical protein [Bacteriophage 933W] gi|4585454|gb|AAD25482.1|AF125520_77; hypothetical protein complement(1305723..1306118) Escherichia coli O157:H7 str. Sakai 913862 NP_309274.1 CDS ECs1247 NC_002695.1 1306118 1306777 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881668|dbj|BAA84359.1, [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein complement(1306118..1306777) Escherichia coli O157:H7 str. Sakai 912992 NP_309275.1 CDS ECs1248 NC_002695.1 1306798 1307016 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881669|dbj|BAA84360.1, [Bacteriophage 933W] gi|7649907|dbj|BAA94185.1; hypothetical protein complement(1306798..1307016) Escherichia coli O157:H7 str. Sakai 912358 NP_309276.1 CDS ECs1249 NC_002695.1 1307003 1307287 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881670|dbj|BAA84361.1; hypothetical protein complement(1307003..1307287) Escherichia coli O157:H7 str. Sakai 914137 NP_309277.1 CDS ECs1250 NC_002695.1 1307284 1307505 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881671|dbj|BAA84362.1, C4-type zinc finger proteins (TraR family) e.g. orf39 [Pseudomonas aeruginosa phage phi CTX] gi|4063813|dbj|BAA36267; C4-type zinc finger TraR complement(1307284..1307505) Escherichia coli O157:H7 str. Sakai 912642 NP_309278.1 CDS ECs1251 NC_002695.1 1307553 1308182 R similar to phage anti-repressor proteins e.g. [Neisseria meningitidis] gi|7379969|emb|CAB84545.1, [Bacteriophage VT2-Sa] gi|5881672|dbj|BAA84363.1, HI1422 [Haemophilus influenzae Rd] gi|1175795|sp|P44193|YE22_HAEIN; anti-repressor protein complement(1307553..1308182) Escherichia coli O157:H7 str. Sakai 912780 NP_309279.2 CDS ECs1252 NC_002695.1 1309331 1310659 R similar to YCDG_ECOLI gi|1787241 (conserved in Escherichia coli K-12); transporter complement(1309331..1310659) Escherichia coli O157:H7 str. Sakai 914118 NP_309280.2 CDS ECs1253 NC_002695.1 1310680 1311174 R similar to B1007_ECOLI gi|1787242 (conserved in Escherichia coli K-12); hypothetical protein complement(1310680..1311174) Escherichia coli O157:H7 str. Sakai 912887 NP_309281.1 CDS ECs1254 NC_002695.1 1311185 1311775 R similar to B1008_ECOLI gi|1787243 (conserved in Escherichia coli K-12); hypothetical protein complement(1311185..1311775) Escherichia coli O157:H7 str. Sakai 912803 NP_309282.1 CDS ECs1255 NC_002695.1 1311785 1312585 R similar to B1009_ECOLI gi|1787244 (conserved in Escherichia coli K-12); acetyltransferase complement(1311785..1312585) Escherichia coli O157:H7 str. Sakai 912509 NP_309283.1 CDS ECs1256 NC_002695.1 1312593 1312979 R similar to B1010_ECOLI gi|1787245 (conserved in Escherichia coli K-12); hypothetical protein complement(1312593..1312979) Escherichia coli O157:H7 str. Sakai 912826 NP_309284.2 CDS ECs1257 NC_002695.1 1312991 1313686 R similar to B1011_ECOLI gi|1787246 (conserved in Escherichia coli K-12); synthetase complement(1312991..1313686) Escherichia coli O157:H7 str. Sakai 912521 NP_309285.2 CDS ECs1258 NC_002695.1 1313683 1314777 R similar to B1012_ECOLI gi|1787247 (conserved in Escherichia coli K-12); hypothetical protein complement(1313683..1314777) Escherichia coli O157:H7 str. Sakai 913968 NP_309286.1 CDS ECs1259 NC_002695.1 1315062 1315700 D similar to YCDC_ECOLI gi|1787249 (conserved in Escherichia coli K-12); tet operon regulator 1315062..1315700 Escherichia coli O157:H7 str. Sakai 912884 NP_309287.1 CDS putA NC_002695.1 1315740 1319702 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(1315740..1319702) Escherichia coli O157:H7 str. Sakai 912875 NP_944514.1 CDS ECs5411 NC_002695.1 1319757 1319966 D hypothetical protein 1319757..1319966 Escherichia coli O157:H7 str. Sakai 2693795 NP_309288.1 CDS ECs1261 NC_002695.1 1320125 1321633 D similar to PUTP_ECOLI gi|1787251 (conserved in Escherichia coli K-12); major sodium/proline symporter 1320125..1321633 Escherichia coli O157:H7 str. Sakai 913007 NP_309289.1 CDS ECs1262 NC_002695.1 1321782 1323125 R hypothetical protein complement(1321782..1323125) Escherichia coli O157:H7 str. Sakai 912603 NP_309290.1 CDS ECs1263 NC_002695.1 1324307 1325137 D similar to B1016_ECOLI gi|1787252, B1017_ECOLI gi|1787253; cytochrome 1324307..1325137 Escherichia coli O157:H7 str. Sakai 912835 NP_309291.1 CDS ECs1264 NC_002695.1 1325195 1326322 D similar to YCDO_ECOLI gi|1787254 (conserved in Escherichia coli K-12); hypothetical protein 1325195..1326322 Escherichia coli O157:H7 str. Sakai 913843 NP_309292.1 CDS ECs1265 NC_002695.1 1326328 1327599 D similar to YCDB_ECOLI gi|1787255 (conserved in Escherichia coli K-12); hypothetical protein 1326328..1327599 Escherichia coli O157:H7 str. Sakai 912778 NP_309293.1 CDS ECs1266 NC_002695.1 1327943 1329007 D ATP-binding pho regulon component; similar to PHOH_ECOLI gi|1787257 (conserved in Escherichia coli K-12); hypothetical protein 1327943..1329007 Escherichia coli O157:H7 str. Sakai 912858 NP_309294.1 CDS pgaD NC_002695.1 1329057 1329470 R in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein complement(1329057..1329470) Escherichia coli O157:H7 str. Sakai 912758 NP_309295.1 CDS ECs1268 NC_002695.1 1329472 1330797 R predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase complement(1329472..1330797) Escherichia coli O157:H7 str. Sakai 912769 NP_309296.1 CDS pgaB NC_002695.1 1330790 1332808 R in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase complement(1330790..1332808) Escherichia coli O157:H7 str. Sakai 912831 NP_309297.1 CDS pgaA NC_002695.1 1332817 1335240 R outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA complement(1332817..1335240) Escherichia coli O157:H7 str. Sakai 912850 NP_309298.1 CDS ECs1271 NC_002695.1 1335827 1337185 D similar to YCDT_ECOLI gi|1787262 (conserved in Escherichia coli K-12); hypothetical protein 1335827..1337185 Escherichia coli O157:H7 str. Sakai 912861 NP_309299.1 CDS ECs1272 NC_002695.1 1337361 1338893 D may confer resistance to phages N4 and lambda; similar to Rtn membrane associated protein [Escherichia coli]gi|2498867|sp|P76446|RTN_ECOLI; rtn-like protein 1337361..1338893 Escherichia coli O157:H7 str. Sakai 912750 NP_309300.1 CDS ECs1273 NC_002695.1 1338995 1339486 R similar to FidL -Salmonella typhimurium gi|4324611|gb|AAD16955.1; FidL-like protein complement(1338995..1339486) Escherichia coli O157:H7 str. Sakai 912797 NP_309301.1 CDS ECs1274 NC_002695.1 1339491 1340303 R similar to transcriptional activators e.g. MarT [Salmonella typhimurium] gi|4324612|gb|AAD16956.1; transcriptional regulator complement(1339491..1340303) Escherichia coli O157:H7 str. Sakai 912774 NP_309302.2 CDS ECs1275 NC_002695.1 1340991 1341773 D similar to oxidoreductases e.g. [Escherichia coli] gi|2492762|sp|P76633|YGCW_ECOLI; oxidoreductase 1340991..1341773 Escherichia coli O157:H7 str. Sakai 912743 NP_309303.1 CDS ECs1276 NC_002695.1 1341919 1342548 R similar to hypothetical proteins e.g. ORF60 [Yersinia pestis] gi|7467334|pir||T17432, chaperone proteins e.g. EcpD [Escherichia coli] gi|2506408|sp|P33128|ECPD_ECOLI; chaperone protein complement(1341919..1342548) Escherichia coli O157:H7 str. Sakai 912817 NP_309304.1 CDS ECs1277 NC_002695.1 1342605 1343939 R similar to hypothetical proteins e.g. ORF59 [Yersinia pestis] gi|4106627|emb|CAA21382.1; outer membrane protein complement(1342605..1343939) Escherichia coli O157:H7 str. Sakai 912506 NP_309305.1 CDS ECs1278 NC_002695.1 1343955 1346477 R similar to hypothetical protein ORF 58 [Yersinia pestis] gi|4106626|emb|CAA21381.1, outer membrane usher proteins e.g. FimD [Salmonella typhimurium gi|585135|sp|P3792; outer membrane usher protein complement(1343955..1346477) Escherichia coli O157:H7 str. Sakai 912793 NP_309306.2 CDS ECs1279 NC_002695.1 1346530 1347252 R similar to hypothetical protein ORF57 [Yersinia pestis] gi|4106625|emb|CAA21380.1, chaperone proteins e.g. EcpD [Escherichia coli] gi|2506408|sp|P33128|ECPD_ECOLI; chaperone protein complement(1346530..1347252) Escherichia coli O157:H7 str. Sakai 912756 NP_309307.1 CDS ECs1280 NC_002695.1 1347317 1347877 R similar to hypothetical protein ORF56 [Yersinia pestis] gi|4106624|emb|CAA21379.1, major pilin proteins e.g. SfaA [Escherichia coli] gi|4105989|gb|AAD02646.1; major pilin protein complement(1347317..1347877) Escherichia coli O157:H7 str. Sakai 912615 NP_309308.1 CDS ECs1281 NC_002695.1 1347920 1348543 R hypothetical protein complement(1347920..1348543) Escherichia coli O157:H7 str. Sakai 912939 NP_309309.1 CDS ECs1282 NC_002695.1 1349940 1353746 D similar to hemagglutinin/hemolysin-related proteins [Neisseria meningitidis] e.g. gi|7225719|gb|AAF40927.1; hemagglutinin/hemolysin-like protein 1349940..1353746 Escherichia coli O157:H7 str. Sakai 912619 NP_309310.1 CDS ECs1283 NC_002695.1 1353835 1355454 D similar to hemolysin activator-related proteins e.g. [Pectobacterium chrysanthemi] gi|1772622|gb|AAC31980.1; hemolysin activator-like protein 1353835..1355454 Escherichia coli O157:H7 str. Sakai 912949 NP_309311.1 CDS ECs1284 NC_002695.1 1355470 1355838 D similar to holo-[acyl-carrier protein] synthases e.g. [Campylobacter jejuni] gi|6968838|emb|CAB73833.1; holo-ACP synthase 1355470..1355838 Escherichia coli O157:H7 str. Sakai 912725 NP_309312.1 CDS ECs1285 NC_002695.1 1356044 1356613 D similar to 3-oxoacyl-(acyl carrier protein) reductases e.g. [Moritella marina] gi|7227179|gb|AAF42251.1; 3-oxoacyl-ACP reductase 1356044..1356613 Escherichia coli O157:H7 str. Sakai 912978 NP_309313.1 CDS ECs1286 NC_002695.1 1356617 1357165 D similar to (3R)-hydroxymyristol-(acyl carrier protein) dehydratases e.g. gi|7190847|gb|AAF39621.1; (3R)-hydroxymyristoyl-ACP dehydratase 1356617..1357165 Escherichia coli O157:H7 str. Sakai 912983 NP_309314.2 CDS ECs1287 NC_002695.1 1357196 1357468 D similar to acyl carrier proteins e.g. AcpC [Streptococcus agalactiae] gi|4886773|gb|AAD32036.1|AF093787_4; acyl carrier protein 1357196..1357468 Escherichia coli O157:H7 str. Sakai 913514 NP_309315.1 CDS ECs1288 NC_002695.1 1357504 1358664 D similar to aminpometyl transferases e.g. gi|7450600|pir||C75088; glycine cleavage system protein T 1357504..1358664 Escherichia coli O157:H7 str. Sakai 912944 NP_309316.1 CDS ECs1289 NC_002695.1 1358738 1361296 D similar to 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41) [Bacillus subtilis] gi|7433750|pir||G69842; 3-oxoacyl-ACP synthase 1358738..1361296 Escherichia coli O157:H7 str. Sakai 912824 NP_309317.1 CDS ECs1290 NC_002695.1 1361544 1362524 D similar to polyketide synthases e.g. [Streptomyces sp. strain MA6548] gi|7481905|pir||T17428; hypothetical protein 1361544..1362524 Escherichia coli O157:H7 str. Sakai 912578 NP_309318.1 CDS ECs1291 NC_002695.1 1362623 1363474 D hypothetical protein 1362623..1363474 Escherichia coli O157:H7 str. Sakai 912942 NP_309319.1 CDS ECs1292 NC_002695.1 1363485 1364192 D similar to ABC transporters (ATP binding proteins) e.g. [Thermotoga maritima] gi|7445988|pir||H72342; ABC transporter ATP-binding protein 1363485..1364192 Escherichia coli O157:H7 str. Sakai 912975 NP_309320.1 CDS ECs1293 NC_002695.1 1364176 1364832 D hypothetical protein 1364176..1364832 Escherichia coli O157:H7 str. Sakai 912977 NP_309321.1 CDS ECs1294 NC_002695.1 1364833 1366143 D similar to hypothetical proteins e.g. BBJ27 [Lyme disease spirochete plasmid J/lp38] gi|7463605|pir||D70248; hypothetical protein 1364833..1366143 Escherichia coli O157:H7 str. Sakai 912523 NP_309322.1 CDS ECs1295 NC_002695.1 1366152 1366940 D hypothetical protein 1366152..1366940 Escherichia coli O157:H7 str. Sakai 916336 NP_309323.1 CDS ECs1296 NC_002695.1 1366937 1368325 D hypothetical protein 1366937..1368325 Escherichia coli O157:H7 str. Sakai 912551 NP_309324.1 CDS ECs1297 NC_002695.1 1368957 1369280 D similar to B1028_ECOLI gi|1787266 (conserved in Escherichia coli K-12); hypothetical protein 1368957..1369280 Escherichia coli O157:H7 str. Sakai 914017 NP_309325.1 CDS ECs1298 NC_002695.1 1369277 1370263 D similar to YCDU_ECOLI gi|1787267 (conserved in Escherichia coli K-12); hypothetical protein 1369277..1370263 Escherichia coli O157:H7 str. Sakai 912971 NP_309326.1 CDS ECs1299 NC_002695.1 1370630 1371832 D similar to integrases e.g. [Vibrio cholerae] gi|498253|gb|AAC44230.1|; integrase 1370630..1371832 Escherichia coli O157:H7 str. Sakai 912968 NP_309327.1 CDS ECs1300 NC_002695.1 1372019 1373836 R similar to hemagglutinin main component [Clostridium botulinum phage (type C)] gi|1346254|sp|P46084|HA33_CLOBO; hypothetical protein complement(1372019..1373836) Escherichia coli O157:H7 str. Sakai 912838 NP_309328.1 CDS ECs1301 NC_002695.1 1374332 1374769 D similar to InsB proteins e.g. [Shigella dysenteriae Iso-IS1] gi|6759959|gb|AAF28117.1|AF153317_13; transposase 1374332..1374769 Escherichia coli O157:H7 str. Sakai 915171 NP_309329.1 CDS ECs1302 NC_002695.1 1374948 1375244 D similar to prophage cp4-57 regulatory protein AlpA [Escherichia coli (strain K-12)] gi|461502|sp|P33997|ALPA_ECOLI; regulatory protein 1374948..1375244 Escherichia coli O157:H7 str. Sakai 912895 NP_944515.1 CDS ECs5412 NC_002695.1 1375471 1375668 D hypothetical protein 1375471..1375668 Escherichia coli O157:H7 str. Sakai 2693745 NP_309330.1 CDS ECs1303 NC_002695.1 1375887 1377272 D similar to hypothetical protein b2625 (YfjI) [Escherichia coli K-12] gi|1723621|sp|P52124|YFJI_ECOLI; hypothetical protein 1375887..1377272 Escherichia coli O157:H7 str. Sakai 913048 NP_309331.1 CDS ECs1304 NC_002695.1 1378093 1378656 D similar to hypothetical protein Cj1244 [Campylobacter jejuni] gi|6968677|emb|CAB73498.1; hypothetical protein 1378093..1378656 Escherichia coli O157:H7 str. Sakai 915173 NP_309332.1 CDS ECs1305 NC_002695.1 1378811 1381171 D similar to hypothetical protein A153R [Chlorella virus PBCV-1] gi|7461298|pir||T17644, DNA repair protein rad25 PAB0128 [Pyrococcus abyssi (strain Orsay)] gi|7514780|pir||A75209; hypothetical protein 1378811..1381171 Escherichia coli O157:H7 str. Sakai 912859 NP_309334.1 CDS ECs1307 NC_002695.1 1381928 1383466 R similar to L0015 [Escherichia coli] gi|3414883|gb|AAC31494.1 and hypothetical protein [Escherichia coli] gi|3288156|emb|CAA11509.1; hypothetical protein complement(1381928..1383466) Escherichia coli O157:H7 str. Sakai 914163 NP_309335.1 CDS ECs1308 NC_002695.1 1383516 1383863 R similar to L0014 [Escherichia coli] gi|3288157|emb|CAA11510.1 and hypothetical proteins e.g. orf50 [Escherichia coli] gi|6009426|dbj|BAA84885.1; hypothetical protein complement(1383516..1383863) Escherichia coli O157:H7 str. Sakai 913484 NP_309336.1 CDS ECs1309 NC_002695.1 1383860 1384261 R similar to hypothetical proteins e.g. L0013 [Escherichia coli] gi|3414881|gb|AAC31492.1|; hypothetical protein complement(1383860..1384261) Escherichia coli O157:H7 str. Sakai 913697 NP_309338.1 CDS ECs1311 NC_002695.1 1384767 1385585 D similar to transposases e.g. Hp1 [Escherichia coli] gi|3661482|gb|AAC61713.1 and InsB [Shigella dysenteriae] gi|5532467|gb|AAD44751.1|AF141323_22; transposase 1384767..1385585 Escherichia coli O157:H7 str. Sakai 912418 NP_309339.1 CDS ECs1312 NC_002695.1 1385491 1386237 D similar to lipoprotein traT precursors e.g. gi|418135|sp|P32885|TRT1_ECOLI; complement resistance protein 1385491..1386237 Escherichia coli O157:H7 str. Sakai 912825 NP_309342.1 CDS ECs1315 NC_002695.1 1386926 1387126 R hypothetical protein complement(1386926..1387126) Escherichia coli O157:H7 str. Sakai 912370 NP_309343.1 CDS ECs1316 NC_002695.1 1387536 1387895 D similar to diacylglycerol kinases e.g. gi|125321|sp|P00556|KDGL_ECOLI; diacylglycerol kinase 1387536..1387895 Escherichia coli O157:H7 str. Sakai 912686 NP_309344.1 CDS ECs1317 NC_002695.1 1387988 1389274 R similar to hypothetical proteins e.g. yjdB in basS-adiY intergenic region [Escherichia coli] gi|731986|sp|P30845|YJDB_ECOLI; outer membrane protein complement(1387988..1389274) Escherichia coli O157:H7 str. Sakai 913035 NP_309346.1 CDS ECs1319 NC_002695.1 1389832 1390107 R hypothetical protein complement(1389832..1390107) Escherichia coli O157:H7 str. Sakai 913342 NP_309347.1 CDS ECs1320 NC_002695.1 1390159 1390362 R hypothetical protein complement(1390159..1390362) Escherichia coli O157:H7 str. Sakai 912706 NP_309348.1 CDS ECs1321 NC_002695.1 1390443 1391186 D similar to UreD [Klebsiella aerogenes] gi|731078|sp|Q09063|URED_KLEAE; hypothetical protein 1390443..1391186 Escherichia coli O157:H7 str. Sakai 912366 NP_309349.1 CDS ureA NC_002695.1 1391277 1391579 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1391277..1391579 Escherichia coli O157:H7 str. Sakai 913824 NP_309350.1 CDS ureB NC_002695.1 1391588 1391908 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1391588..1391908 Escherichia coli O157:H7 str. Sakai 913707 NP_309351.1 CDS ureC NC_002695.1 1391898 1393604 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1391898..1393604 Escherichia coli O157:H7 str. Sakai 913507 NP_309352.1 CDS ureE NC_002695.1 1393614 1394078 D involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1393614..1394078 Escherichia coli O157:H7 str. Sakai 913913 NP_309353.1 CDS ECs1326 NC_002695.1 1394079 1394753 D urease accessory protein; similar to urease accessory proteins UreF e.g. [Klebsiella aerogenes] gi|137097|sp|P18318|UREF_KLEAE; UreF 1394079..1394753 Escherichia coli O157:H7 str. Sakai 912425 NP_309354.1 CDS ECs1327 NC_002695.1 1394765 1395382 D urease accessory protein; similar to UreG urease accessory proteins e.g. [Klebsiella aerogenes] gi|137099|sp|P18319|UREG_KLEAE; protein UreG 1394765..1395382 Escherichia coli O157:H7 str. Sakai 912768 NP_309355.1 CDS ECs1328 NC_002695.1 1395638 1395979 R similar to TnpJ [Shigella flexneri] gi|5532468|gb|AAD44752.1|AF141323_23; hypothetical protein complement(1395638..1395979) Escherichia coli O157:H7 str. Sakai 914200 NP_309357.1 CDS rpmE2 NC_002695.1 1396594 1396857 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1396594..1396857 Escherichia coli O157:H7 str. Sakai 912490 NP_944516.1 CDS ECs5413 NC_002695.1 1397159 1397299 D hypothetical protein 1397159..1397299 Escherichia coli O157:H7 str. Sakai 2693820 NP_309361.1 CDS ECs1334 NC_002695.1 1399045 1399200 R hypothetical protein complement(1399045..1399200) Escherichia coli O157:H7 str. Sakai 912624 NP_309362.1 CDS ECs1335 NC_002695.1 1399917 1400678 D hypothetical protein 1399917..1400678 Escherichia coli O157:H7 str. Sakai 913845 NP_309363.1 CDS ECs1336 NC_002695.1 1400375 1400974 R similar to hypothetical protein [Pseudomonas putida] gi|2995633|gb|AAC98738.1 and L0015 [Escherichia coli] gi|3414883|gb|AAC31494.1; hypothetical protein complement(1400375..1400974) Escherichia coli O157:H7 str. Sakai 913780 NP_309364.1 CDS ECs1337 NC_002695.1 1401180 1401605 D similar to hypothetical protein orf29 [Escherichia coli] gi|6009405|dbj|BAA84864.1 and L0013 [Escherichia coli] gi|3414881|gb|AAC31492.1; hypothetical protein 1401180..1401605 Escherichia coli O157:H7 str. Sakai 913904 NP_309365.1 CDS ECs1338 NC_002695.1 1401602 1401952 D similar to hypothetical protein orf50 [Escherichia coli] gi|6009426|dbj|BAA84885.1 and L0014 [Escherichia coli] gi|3288157|emb|CAA11510.1; hypothetical protein 1401602..1401952 Escherichia coli O157:H7 str. Sakai 912312 NP_309366.1 CDS ECs1339 NC_002695.1 1401983 1403596 D similar to hypothetical protein L0015 [Escherichia coli] gi|3414883|gb|AAC31494.1; hypothetical protein 1401983..1403596 Escherichia coli O157:H7 str. Sakai 913949 NP_309367.1 CDS ECs1340 NC_002695.1 1403600 1404328 R similar to hypothetical protein 57.8 kD protein [Pseudomonas putida] gi|2496740|sp|P55630|Y4QI_RHISN; hypothetical protein complement(1403600..1404328) Escherichia coli O157:H7 str. Sakai 913578 NP_309370.1 CDS ECs1343 NC_002695.1 1405457 1405924 R immunity to R478 phage/colicin/tellurite resistance cluster; similar to TerW [Plasmid R478] gi|1354147|gb|AAC44736.1; TerW protein complement(1405457..1405924) Escherichia coli O157:H7 str. Sakai 912463 NP_309371.1 CDS ECs1344 NC_002695.1 1405942 1407150 R hypothetical protein complement(1405942..1407150) Escherichia coli O157:H7 str. Sakai 913679 NP_309372.1 CDS ECs1345 NC_002695.1 1407161 1408117 R similar to hypothetical protein [Deinococcus radiodurans] gi|7472167|pir||B75302; hypothetical protein complement(1407161..1408117) Escherichia coli O157:H7 str. Sakai 913346 NP_309373.1 CDS ECs1346 NC_002695.1 1408117 1408851 R similar to hypothetical protein [Streptomyces coelicolor A3(2)] gi|7472048|pir||A75302; hypothetical protein complement(1408117..1408851) Escherichia coli O157:H7 str. Sakai 913265 NP_309374.1 CDS ECs1347 NC_002695.1 1408853 1409233 R similar to hypothetical protein [Streptomyces coelicolor A3(2)] gi|8246803|emb|CAB92838.1; hypothetical protein complement(1408853..1409233) Escherichia coli O157:H7 str. Sakai 913886 NP_309375.1 CDS ECs1348 NC_002695.1 1409199 1409972 R similar to hypothetical protein [Serratia marcescens] gi|1695868|gb|AAB37122.1; hypothetical protein complement(1409199..1409972) Escherichia coli O157:H7 str. Sakai 912882 NP_309376.1 CDS ECs1349 NC_002695.1 1409965 1411107 R similar to hypothetical protein [Serratia marcescens] gi|1695869|gb|AAB37123.1, [Deinococcus radiodurans (strain R1)] gi|7471591|pir||F75301; hypothetical protein complement(1409965..1411107) Escherichia coli O157:H7 str. Sakai 912691 NP_309377.1 CDS ECs1350 NC_002695.1 1411117 1412175 R similar to hypothetical protein [Serratia marcescens] gi|1695870|gb|AAB37124.1, [Serratia marcescens] gi|1695871|gb|AAB37125.1, [Deinococcus radiodurans] gi|7471522|pir||E7530; hypothetical protein complement(1411117..1412175) Escherichia coli O157:H7 str. Sakai 913123 NP_309378.1 CDS ECs1351 NC_002695.1 1412498 1413079 D tellurium resistance protein; similar to TerZ protein [Serratia marcescens] gi|6094454|sp|Q52353; protein TerZ 1412498..1413079 Escherichia coli O157:H7 str. Sakai 912773 NP_309379.1 CDS ECs1352 NC_002695.1 1413211 1414236 D tellurium resistance protein; similar to TerA protein [Serratia marcescens] gi|5702379|gb|AAD47285.1|AF168355_3; protein TerA 1413211..1414236 Escherichia coli O157:H7 str. Sakai 912536 NP_309380.1 CDS ECs1353 NC_002695.1 1414259 1414714 D tellurium resistance protein; similar to TerB protein [Serratia marcescens] gi|950680|gb|AAA86848.1; protein TerB 1414259..1414714 Escherichia coli O157:H7 str. Sakai 913092 NP_309381.1 CDS ECs1354 NC_002695.1 1414737 1415777 D tellurium resistance protein; similar to TerC protein [Serratia marcescens] gi|6226214|sp|Q52356|TERC_SERMA; protein TerC 1414737..1415777 Escherichia coli O157:H7 str. Sakai 913363 NP_309382.1 CDS ECs1355 NC_002695.1 1415826 1416404 D tellurium resistance protein; similar to terD proteins e.g. [Serratia marcescens] gi|6094448|sp|Q52357|TERD_SERMA; protein TerD 1415826..1416404 Escherichia coli O157:H7 str. Sakai 912680 NP_309383.1 CDS ECs1356 NC_002695.1 1416473 1417048 D tellurium resistance protein; similar to gi|7108482|gb|AAF36434.1|AF126104_3 TLRB_ECOLI, TerE [Serratia marcescens] gi|6094449|sp|Q52358|TERE_SERMA; protein TerE 1416473..1417048 Escherichia coli O157:H7 str. Sakai 912662 NP_309384.1 CDS ECs1357 NC_002695.1 1417073 1417276 D hypothetical protein 1417073..1417276 Escherichia coli O157:H7 str. Sakai 912343 NP_309386.1 CDS ECs1359 NC_002695.1 1417912 1418136 R hypothetical protein complement(1417912..1418136) Escherichia coli O157:H7 str. Sakai 912576 NP_309387.1 CDS ECs1360 NC_002695.1 1418370 1420460 R IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein complement(1418370..1420460) Escherichia coli O157:H7 str. Sakai 912400 NP_309389.1 CDS ECs1362 NC_002695.1 1421859 1422131 D similar to ShiA [Shigella flexneri] gi|5532447|gb|AAD44731.1|AF141323_2; hypothetical protein 1421859..1422131 Escherichia coli O157:H7 str. Sakai 913263 NP_309391.1 CDS ECs1364 NC_002695.1 1423880 1424074 R hypothetical protein complement(1423880..1424074) Escherichia coli O157:H7 str. Sakai 912639 NP_309392.1 CDS ECs1365 NC_002695.1 1424154 1424378 D hypothetical protein 1424154..1424378 Escherichia coli O157:H7 str. Sakai 912311 NP_309393.1 CDS ECs1366 NC_002695.1 1424394 1424666 D hypothetical protein 1424394..1424666 Escherichia coli O157:H7 str. Sakai 916558 NP_309394.1 CDS ECs1367 NC_002695.1 1424971 1425165 D hypothetical protein 1424971..1425165 Escherichia coli O157:H7 str. Sakai 915289 NP_944517.1 CDS ECs5414 NC_002695.1 1425231 1425428 D hypothetical protein 1425231..1425428 Escherichia coli O157:H7 str. Sakai 2693821 NP_309397.1 CDS ECs1370 NC_002695.1 1426158 1427282 D similar to glucosyl-transferases [Salmonella typhi] gi|7467230|pir||T30292; glucosyl-transferase 1426158..1427282 Escherichia coli O157:H7 str. Sakai 912409 NP_309399.1 CDS ECs1372 NC_002695.1 1427701 1428204 R similar to transposases e.g. [Shigella boydii] gi|2197010|gb|AAB61273.1; transposase complement(1427701..1428204) Escherichia coli O157:H7 str. Sakai 914906 NP_309400.1 CDS ECs1373 NC_002695.1 1428123 1428398 R repressor; similar to InsA proteins e.g. [insertion sequence IS1F] gi|124915|sp|P19767|ISA2_ECOLI; hypothetical protein complement(1428123..1428398) Escherichia coli O157:H7 str. Sakai 912500 NP_309401.1 CDS ECs1374 NC_002695.1 1428636 1429094 R hypothetical protein complement(1428636..1429094) Escherichia coli O157:H7 str. Sakai 913813 NP_309402.1 CDS ECs1375 NC_002695.1 1429159 1429350 D hypothetical protein 1429159..1429350 Escherichia coli O157:H7 str. Sakai 914866 NP_309403.1 CDS ECs1376 NC_002695.1 1429552 1430061 D hypothetical protein 1429552..1430061 Escherichia coli O157:H7 str. Sakai 912401 NP_309404.1 CDS ECs1377 NC_002695.1 1430150 1430773 D similar to sensor-regulator protein HutT [Rhodobacter capsulatus] gi|1075537|pir||A49938; hypothetical protein 1430150..1430773 Escherichia coli O157:H7 str. Sakai 915129 NP_309405.1 CDS ECs1378 NC_002695.1 1430869 1431102 D hypothetical protein 1430869..1431102 Escherichia coli O157:H7 str. Sakai 913726 NP_309406.1 CDS ECs1379 NC_002695.1 1431113 1431328 D hypothetical protein 1431113..1431328 Escherichia coli O157:H7 str. Sakai 913994 NP_944518.1 CDS ECs5415 NC_002695.1 1431155 1431346 R hypothetical protein complement(1431155..1431346) Escherichia coli O157:H7 str. Sakai 2693822 NP_309407.1 CDS ECs1380 NC_002695.1 1431940 1432827 R OrfB; similar to transposase [insertion sequenceIS629] gi|7443863|pir||T00315; transposase complement(1431940..1432827) Escherichia coli O157:H7 str. Sakai 914090 NP_309408.1 CDS ECs1381 NC_002695.1 1432827 1433153 R OrfA; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase complement(1432827..1433153) Escherichia coli O157:H7 str. Sakai 912467 NP_309409.1 CDS ECs1382 NC_002695.1 1433646 1434380 D similar to hemolysin activation protein HecB [Neisseria meningitidis MC58] gi|7227016|gb|AAF42103.1; HecB-like protein 1433646..1434380 Escherichia coli O157:H7 str. Sakai 912541 NP_309413.1 CDS ECs1386 NC_002695.1 1437802 1439034 D similar to hypothetical protein YbdN [Escherichia coli] gi|3024984|sp|P77216|YBDN_ECOLI; hypothetical protein 1437802..1439034 Escherichia coli O157:H7 str. Sakai 912382 NP_309414.1 CDS ECs1387 NC_002695.1 1439019 1439657 D similar to hypothetical protein YbdM [Escherichia coli] gi|3024983|sp|P77174|YBDM_ECOLI; hypothetical protein 1439019..1439657 Escherichia coli O157:H7 str. Sakai 913299 NP_309415.1 CDS ECs1388 NC_002695.1 1439736 1440005 D similar to PerC (BfpW) [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional regulator 1439736..1440005 Escherichia coli O157:H7 str. Sakai 913436 NP_309416.1 CDS ECs1389 NC_002695.1 1440026 1440670 D similar to exopolyphosphatase [Pseudomonas aeruginosa] gi|4200042|dbj|BAA74460.1; hypothetical protein 1440026..1440670 Escherichia coli O157:H7 str. Sakai 912545 NP_309419.1 CDS ECs1392 NC_002695.1 1441434 1441655 D similar to hypothetical protein [Pseudomonas syringae] gi|1196744|gb|AAA88435; hypothetical protein 1441434..1441655 Escherichia coli O157:H7 str. Sakai 913190 NP_309420.1 CDS ECs1393 NC_002695.1 1441670 1442095 D similar to hypothetical protein orf29 [Escherichia coli] gi|6009405|dbj|BAA84864.1, L0013 [Escherichia coli] gi|3414881|gb|AAC31492.1; hypothetical protein 1441670..1442095 Escherichia coli O157:H7 str. Sakai 913807 NP_309421.1 CDS ECs1394 NC_002695.1 1442395 1442577 R hypothetical protein complement(1442395..1442577) Escherichia coli O157:H7 str. Sakai 914450 NP_309422.1 CDS ECs1395 NC_002695.1 1442906 1443778 D similar to hypothetical proteins e.g. yfjP protein [Escherichia coli] gi|7449539|pir||B65042, YeeP [Escherichia coli] gi|2495624|sp|P76359|YEEP_ECOLI; hypothetical protein 1442906..1443778 Escherichia coli O157:H7 str. Sakai 914784 NP_309423.1 CDS ECs1396 NC_002695.1 1444150 1446999 D similar to adhesin AIDA-I precursor [Escherichia coli plasmid pIB6] gi|543788|sp|Q03155|AIDA_ECOLI, glycoprotein [Escherichia coli strain H10407] gi|5305639|gb|AAD41751.1, outer membrane fluffing protein [Escherichia coli] gi|7466262|pir||G64964; adhesin-like protein; AidA-I 1444150..1446999 Escherichia coli O157:H7 str. Sakai 912599 NP_309424.1 CDS ECs1397 NC_002695.1 1447110 1449494 D similar to hypothetical protein YjDA [Escherichia coli] gi|731985|sp|P16694|YJDA_ECOLI; hypothetical protein 1447110..1449494 Escherichia coli O157:H7 str. Sakai 912553 NP_309425.1 CDS ECs1398 NC_002695.1 1449491 1450396 D similar to hypothetical protein YjcZ [Escherichia coli] gi|731984|sp|P39267|YJCZ_ECOLI; hypothetical protein 1449491..1450396 Escherichia coli O157:H7 str. Sakai 912390 NP_309426.1 CDS ECs1399 NC_002695.1 1450393 1451463 D hypothetical protein 1450393..1451463 Escherichia coli O157:H7 str. Sakai 913466 NP_309427.1 CDS ECs1400 NC_002695.1 1451568 1451732 R hypothetical protein complement(1451568..1451732) Escherichia coli O157:H7 str. Sakai 912753 NP_309428.1 CDS ECs1401 NC_002695.1 1451803 1452621 D similar to hypothetical protein YfjQ [Escherichia coli] gi|1723629|sp|P52132|YFJQ_ECOLI, YafZ [Escherichia coli] gi|2495487|sp|P77206|YAFZ_ECOLI; hypothetical protein 1451803..1452621 Escherichia coli O157:H7 str. Sakai 914069 NP_309429.1 CDS ECs1402 NC_002695.1 1452712 1453197 D similar to hypothetical protein YafK [Escherichia coli] gi|2495486|sp|P75676|YAFX_ECOLI, YfjX [Escherichia coli] gi|1723636|sp|P52139|YFJX_ECOLI; hypothetical protein 1452712..1453197 Escherichia coli O157:H7 str. Sakai 913948 NP_309430.1 CDS ECs1403 NC_002695.1 1453213 1453689 D probable DNA repair protein (RadC family), similar to RadC family protein YkfG [Escherichia coli] gi|3025218|sp|Q47685|YKFG_ECOLI, YeeS [Escherichia coli] gi|3025155|sp|P76362|YEES_ECOLI; DNA repair protein 1453213..1453689 Escherichia coli O157:H7 str. Sakai 912368 NP_309431.1 CDS ECs1404 NC_002695.1 1453752 1453973 D similar to hypothetical protein YeeT [Escherichia coli] gi|3025156|sp|P76363|YEET_ECOLI; hypothetical protein 1453752..1453973 Escherichia coli O157:H7 str. Sakai 912387 NP_309432.1 CDS ECs1405 NC_002695.1 1454136 1454510 D similar to hypothetical protein YeeU [Escherichia coli] gi|3025157|sp|P76364|YEEU_ECOLI, YfjZ [Escherichia coli] gi|1723638|sp|P52141|YFJZ_ECOLI; hypothetical protein 1454136..1454510 Escherichia coli O157:H7 str. Sakai 914193 NP_309433.1 CDS ECs1406 NC_002695.1 1454557 1454931 D similar to hypothetical protein L0007 [Escherichia coli] gi|3414875|gb|AAC31486.1, YeeV [Escherichia coli] gi|3025158|sp|P76365|YEEV_ECOLI, YkfI [Escherichia coli] gi|3025213|s; hypothetical protein 1454557..1454931 Escherichia coli O157:H7 str. Sakai 912823 NP_309434.1 CDS ECs1407 NC_002695.1 1454928 1455419 D similar to hypothetical protein L0008 [Escherichia coli] gi|3414876|gb|AAC31487.1, YeeW [Escherichia coli] gi|3025160|sp|P76366|YEEW_ECOLI; hypothetical protein 1454928..1455419 Escherichia coli O157:H7 str. Sakai 912406 NP_309435.1 CDS ECs1408 NC_002695.1 1455431 1455628 D similar to hypothetical protein L0009 [Escherichia coli] gi|3414877|gb|AAC31488.1; hypothetical protein 1455431..1455628 Escherichia coli O157:H7 str. Sakai 912560 NP_309436.1 CDS ECs1409 NC_002695.1 1455713 1456555 D similar to hypothetical protein L0010 [Escherichia coli] gi|3414878|gb|AAC31489.1, ydiA [Plasmid ColIb-P9] gi|4512489|dbj|BAA75138.1, L0012 [Escherichia coli] gi|3414880|gb|A; hypothetical protein 1455713..1456555 Escherichia coli O157:H7 str. Sakai 912327 NP_309437.1 CDS ECs1410 NC_002695.1 1456987 1457964 D similar to YCDW_ECOLI gi|1787270 (conserved in Escherichia coli K-12); dehydrogenase 1456987..1457964 Escherichia coli O157:H7 str. Sakai 914357 NP_309438.1 CDS ECs1411 NC_002695.1 1458019 1458756 D similar to YCDX_ECOLI gi|1787271 (conserved in Escherichia coli K-12); hydrolase 1458019..1458756 Escherichia coli O157:H7 str. Sakai 912538 NP_309439.1 CDS ECs1412 NC_002695.1 1458780 1459334 D similar to YCDY_ECOLI gi|1787272 (conserved in Escherichia coli K-12); oxidoreductase component 1458780..1459334 Escherichia coli O157:H7 str. Sakai 912375 NP_309440.2 CDS ECs1413 NC_002695.1 1459406 1459927 D similar to YCDZ_ECOLI gi|1787273 (conserved in Escherichia coli K-12); hypothetical protein 1459406..1459927 Escherichia coli O157:H7 str. Sakai 914162 NP_309441.1 CDS ECs1414 NC_002695.1 1459991 1460824 R curli production assembly/transport component; similar to CSGG_ECOLI gi|1787274 (conserved in Escherichia coli K-12); protein CsgG complement(1459991..1460824) Escherichia coli O157:H7 str. Sakai 914144 NP_309442.1 CDS ECs1415 NC_002695.1 1460851 1461267 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1460851..1461267) Escherichia coli O157:H7 str. Sakai 913765 NP_309443.1 CDS ECs1416 NC_002695.1 1461292 1461681 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1461292..1461681) Escherichia coli O157:H7 str. Sakai 912466 NP_309444.1 CDS ECs1417 NC_002695.1 1461686 1462336 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1461686..1462336) Escherichia coli O157:H7 str. Sakai 913469 NP_309445.1 CDS ECs1418 NC_002695.1 1462748 1462987 R hypothetical protein complement(1462748..1462987) Escherichia coli O157:H7 str. Sakai 913642 NP_309446.1 CDS ECs1419 NC_002695.1 1463090 1463545 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1463090..1463545 Escherichia coli O157:H7 str. Sakai 912479 NP_309447.1 CDS ECs1420 NC_002695.1 1463586 1464044 D similar to CSGA_ECOLI gi|1787279 (conserved in Escherichia coli K-12); cryptic curlin major subunit 1463586..1464044 Escherichia coli O157:H7 str. Sakai 913991 NP_309448.1 CDS csgC NC_002695.1 1464103 1464435 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1464103..1464435 Escherichia coli O157:H7 str. Sakai 912415 NP_309449.1 CDS ECs1422 NC_002695.1 1464556 1464867 D similar to B1044_ECOLI gi|1787281 (conserved in Escherichia coli K-12); hypothetical protein 1464556..1464867 Escherichia coli O157:H7 str. Sakai 912307 NP_309450.1 CDS ECs1423 NC_002695.1 1464962 1465495 D similar to B1045_ECOLI gi|1787283 (conserved in Escherichia coli K-12); hypothetical protein 1464962..1465495 Escherichia coli O157:H7 str. Sakai 912957 NP_309451.1 CDS ECs1424 NC_002695.1 1465437 1466918 D similar to YMDC_ECOLI gi|1787284 (conserved in Escherichia coli K-12); synthase 1465437..1466918 Escherichia coli O157:H7 str. Sakai 912591 NP_309452.1 CDS mdoC NC_002695.1 1466926 1468083 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1466926..1468083) Escherichia coli O157:H7 str. Sakai 914215 NP_309453.1 CDS mdoG NC_002695.1 1468476 1470011 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1468476..1470011 Escherichia coli O157:H7 str. Sakai 912482 NP_309454.1 CDS ECs1427 NC_002695.1 1469974 1472547 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1469974..1472547 Escherichia coli O157:H7 str. Sakai 913619 NP_309455.1 CDS ECs1428 NC_002695.1 1472720 1472947 D similar to YCEK_ECOLI gi|1787288 (conserved in Escherichia coli K-12); hypothetical protein 1472720..1472947 Escherichia coli O157:H7 str. Sakai 912402 NP_309456.2 CDS ECs1429 NC_002695.1 1472948 1473322 R acidic protein; similar to MSYB_ECOLI gi|1787289 (conserved in Escherichia coli K-12); hypothetical protein complement(1472948..1473322) Escherichia coli O157:H7 str. Sakai 914483 NP_309459.1 CDS ECs1432 NC_002695.1 1474803 1475723 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1474803..1475723) Escherichia coli O157:H7 str. Sakai 912457 NP_309460.1 CDS ECs1433 NC_002695.1 1475948 1477000 D similar to YCEA_ECOLI gi|1787294 (conserved in Escherichia coli K-12); hypothetical protein 1475948..1477000 Escherichia coli O157:H7 str. Sakai 913919 NP_309461.1 CDS ECs1434 NC_002695.1 1477042 1477617 R similar to YCEI_ECOLI gi|1787295 (conserved in Escherichia coli K-12); hypothetical protein complement(1477042..1477617) Escherichia coli O157:H7 str. Sakai 912645 NP_309462.1 CDS ECs1435 NC_002695.1 1477621 1478187 R similar to B1057_ECOLI gi|1787296 (conserved in Escherichia coli K-12); cytochrome complement(1477621..1478187) Escherichia coli O157:H7 str. Sakai 914197 NP_309463.1 CDS ECs1436 NC_002695.1 1478448 1478588 R similar to YCEO_ECOLI gi|1787297 (conserved in Escherichia coli K-12); hypothetical protein complement(1478448..1478588) Escherichia coli O157:H7 str. Sakai 914276 NP_309464.1 CDS solA NC_002695.1 1478609 1479727 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1478609..1479727) Escherichia coli O157:H7 str. Sakai 912344 NP_309465.3 CDS bssS NC_002695.1 1479842 1480096 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1479842..1480096) Escherichia coli O157:H7 str. Sakai 912354 NP_309466.1 CDS ECs1439 NC_002695.1 1480386 1480631 R damage-inducible protein; similar to DINI_ECOLI gi|1787300 (conserved in Escherichia coli K-12); DNA damage-inducible protein I complement(1480386..1480631) Escherichia coli O157:H7 str. Sakai 912326 NP_309467.1 CDS ECs1440 NC_002695.1 1480705 1481751 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1480705..1481751) Escherichia coli O157:H7 str. Sakai 914110 NP_309468.1 CDS ECs1441 NC_002695.1 1481857 1482417 R similar to YCEB_ECOLI gi|1787302 (conserved in Escherichia coli K-12); hypothetical protein complement(1481857..1482417) Escherichia coli O157:H7 str. Sakai 914105 NP_309469.1 CDS ECs1442 NC_002695.1 1482551 1483198 R cofactor involved in the reduction of disulfides; glutaredoxin complement(1482551..1483198) Escherichia coli O157:H7 str. Sakai 912384 NP_309470.2 CDS ECs1443 NC_002695.1 1483262 1484470 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1483262..1484470) Escherichia coli O157:H7 str. Sakai 912474 NP_309471.1 CDS ECs1444 NC_002695.1 1484706 1485290 D similar to RIMJ_ECOLI gi|1787305 (conserved in Escherichia coli K-12); ribosomal-protein-S5-alanine N-acetyltransferase 1484706..1485290 Escherichia coli O157:H7 str. Sakai 912337 NP_309472.1 CDS ECs1445 NC_002695.1 1485301 1485948 D similar to YCEH_ECOLI gi|1787306 (conserved in Escherichia coli K-12); hypothetical protein 1485301..1485948 Escherichia coli O157:H7 str. Sakai 913563 NP_309473.1 CDS ECs1446 NC_002695.1 1485950 1486873 D similar to MVIM_ECOLI gi|1787307 (conserved in Escherichia coli K-12); hypothetical protein 1485950..1486873 Escherichia coli O157:H7 str. Sakai 914354 NP_309474.1 CDS ECs1447 NC_002695.1 1486983 1488518 D similar to MVIN_ECOLI gi|1787309 (conserved in Escherichia coli K-12); hypothetical protein 1486983..1488518 Escherichia coli O157:H7 str. Sakai 912988 NP_309475.1 CDS ECs1448 NC_002695.1 1488558 1488974 R similar to FLGN_ECOLI gi|1787310 (conserved in Escherichia coli K-12); flagella synthesis protein FlgN complement(1488558..1488974) Escherichia coli O157:H7 str. Sakai 912372 NP_309476.1 CDS ECs1449 NC_002695.1 1488979 1489272 R regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM complement(1488979..1489272) Escherichia coli O157:H7 str. Sakai 912416 NP_309477.1 CDS flgA NC_002695.1 1489348 1490007 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1489348..1490007) Escherichia coli O157:H7 str. Sakai 913008 NP_309478.1 CDS flgB NC_002695.1 1490162 1490578 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1490162..1490578 Escherichia coli O157:H7 str. Sakai 913983 NP_309479.1 CDS flgC NC_002695.1 1490582 1490986 D with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1490582..1490986 Escherichia coli O157:H7 str. Sakai 913368 NP_309480.1 CDS flgD NC_002695.1 1490998 1491693 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1490998..1491693 Escherichia coli O157:H7 str. Sakai 912974 NP_309481.1 CDS flgE NC_002695.1 1491718 1492923 D the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1491718..1492923 Escherichia coli O157:H7 str. Sakai 914188 NP_309482.1 CDS flgF NC_002695.1 1492943 1493698 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1492943..1493698 Escherichia coli O157:H7 str. Sakai 912868 NP_309483.1 CDS flgG NC_002695.1 1493836 1494618 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1493836..1494618 Escherichia coli O157:H7 str. Sakai 912784 NP_309484.1 CDS flgH NC_002695.1 1494671 1495369 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1494671..1495369 Escherichia coli O157:H7 str. Sakai 912879 NP_309485.2 CDS flgI NC_002695.1 1495378 1496478 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1495378..1496478 Escherichia coli O157:H7 str. Sakai 913952 NP_309486.1 CDS flgJ NC_002695.1 1496478 1497419 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1496478..1497419 Escherichia coli O157:H7 str. Sakai 912388 NP_309487.1 CDS flgK NC_002695.1 1497485 1499128 D with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1497485..1499128 Escherichia coli O157:H7 str. Sakai 914101 NP_309488.1 CDS flgL NC_002695.1 1499140 1500093 D with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1499140..1500093 Escherichia coli O157:H7 str. Sakai 913031 NP_309489.1 CDS rne NC_002695.1 1500288 1503473 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1500288..1503473) Escherichia coli O157:H7 str. Sakai 912764 NP_309490.1 CDS ECs1463 NC_002695.1 1503554 1503928 D similar to B1085_ECOLI gi|1787326 (conserved in Escherichia coli K-12); hypothetical protein 1503554..1503928 Escherichia coli O157:H7 str. Sakai 913605 NP_309491.1 CDS ECs1464 NC_002695.1 1504046 1505005 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1504046..1505005 Escherichia coli O157:H7 str. Sakai 913470 NP_309492.2 CDS maf NC_002695.1 1505106 1505690 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1505106..1505690) Escherichia coli O157:H7 str. Sakai 912761 NP_309493.1 CDS ECs1466 NC_002695.1 1505889 1506410 D similar to YCED_ECOLI gi|1787329 (conserved in Escherichia coli K-12); hypothetical protein 1505889..1506410 Escherichia coli O157:H7 str. Sakai 912718 NP_309494.1 CDS rpmF NC_002695.1 1506462 1506635 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1506462..1506635 Escherichia coli O157:H7 str. Sakai 912317 NP_309495.2 CDS ECs1468 NC_002695.1 1506716 1507786 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1506716..1507786 Escherichia coli O157:H7 str. Sakai 913798 NP_309496.1 CDS ECs1469 NC_002695.1 1507854 1508807 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1507854..1508807 Escherichia coli O157:H7 str. Sakai 913793 NP_309497.1 CDS ECs1470 NC_002695.1 1508823 1509752 D similar to FABD_ECOLI gi|1787334 (conserved in Escherichia coli K-12); ACP S-malonyltransferase 1508823..1509752 Escherichia coli O157:H7 str. Sakai 913863 NP_309498.1 CDS fabG NC_002695.1 1509765 1510499 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1509765..1510499 Escherichia coli O157:H7 str. Sakai 913011 NP_309499.1 CDS acpP NC_002695.1 1510710 1510946 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1510710..1510946 Escherichia coli O157:H7 str. Sakai 912360 NP_309500.1 CDS ECs1473 NC_002695.1 1511034 1512275 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1511034..1512275 Escherichia coli O157:H7 str. Sakai 912652 NP_309501.1 CDS ECs1474 NC_002695.1 1512395 1513204 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1512395..1513204 Escherichia coli O157:H7 str. Sakai 913214 NP_309502.1 CDS ECs1475 NC_002695.1 1513207 1514229 D similar to YCEG_ECOLI gi|1787339 (conserved in Escherichia coli K-12); hypothetical protein 1513207..1514229 Escherichia coli O157:H7 str. Sakai 912665 NP_309503.1 CDS tmk NC_002695.1 1514219 1514860 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1514219..1514860 Escherichia coli O157:H7 str. Sakai 912609 NP_309504.1 CDS ECs1477 NC_002695.1 1514857 1515861 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1514857..1515861 Escherichia coli O157:H7 str. Sakai 912962 NP_309505.1 CDS ECs1478 NC_002695.1 1515872 1516669 D similar to YCFH_ECOLI gi|1787342 (conserved in Escherichia coli K-12); metallodependent hydrolase 1515872..1516669 Escherichia coli O157:H7 str. Sakai 913835 NP_309506.1 CDS ECs1479 NC_002695.1 1516964 1518397 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1516964..1518397 Escherichia coli O157:H7 str. Sakai 912363 NP_309507.1 CDS ECs1480 NC_002695.1 1518457 1520646 R similar to FHUE_ECOLI gi|1787344 (conserved in Escherichia coli K-12); ferric-rhodotorulic acid outer membrane transporter complement(1518457..1520646) Escherichia coli O157:H7 str. Sakai 913890 NP_309508.2 CDS ECs1481 NC_002695.1 1520974 1521351 D similar to YCFF_ECOLI gi|1787346 (conserved in Escherichia coli K-12); purine nucleoside phosphoramidase 1520974..1521351 Escherichia coli O157:H7 str. Sakai 912424 NP_309509.1 CDS ECs1482 NC_002695.1 1521354 1521731 D similar to YCFL_ECOLI gi|1787347 (conserved in Escherichia coli K-12); hypothetical protein 1521354..1521731 Escherichia coli O157:H7 str. Sakai 912483 NP_309510.1 CDS ECs1483 NC_002695.1 1521745 1522386 D similar to YCFM_ECOLI gi|1787348 (conserved in Escherichia coli K-12); hypothetical protein 1521745..1522386 Escherichia coli O157:H7 str. Sakai 913505 NP_309511.1 CDS thiK NC_002695.1 1522367 1523191 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1522367..1523191 Escherichia coli O157:H7 str. Sakai 913746 NP_309512.1 CDS ECs1485 NC_002695.1 1523202 1524227 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1523202..1524227 Escherichia coli O157:H7 str. Sakai 913266 NP_309513.2 CDS ECs1486 NC_002695.1 1524250 1524792 D similar to YCFP_ECOLI gi|1787351 (conserved in Escherichia coli K-12); hypothetical protein 1524250..1524792 Escherichia coli O157:H7 str. Sakai 912679 NP_309514.1 CDS ECs1487 NC_002695.1 1525192 1526496 D similar to NDH_ECOLI gi|1787352 (conserved in Escherichia coli K-12); NADH dehydrogenase 1525192..1526496 Escherichia coli O157:H7 str. Sakai 913292 NP_309515.1 CDS ECs1488 NC_002695.1 1526723 1527262 D similar to YCFJ_ECOLI gi|1787353 (conserved in Escherichia coli K-12); hypothetical protein 1526723..1527262 Escherichia coli O157:H7 str. Sakai 912979 NP_309516.2 CDS ECs1489 NC_002695.1 1527324 1527956 R similar to YCFQ_ECOLI gi|1787354 (conserved in Escherichia coli K-12); hypothetical protein complement(1527324..1527956) Escherichia coli O157:H7 str. Sakai 912848 NP_309517.1 CDS ECs1490 NC_002695.1 1528197 1528454 D similar to YCFR_ECOLI gi|1787355 (conserved in Escherichia coli K-12); hypothetical protein 1528197..1528454 Escherichia coli O157:H7 str. Sakai 912348 NP_309518.1 CDS ECs1491 NC_002695.1 1528537 1529499 R similar to YCFS_ECOLI gi|1787356 (conserved in Escherichia coli K-12); hypothetical protein complement(1528537..1529499) Escherichia coli O157:H7 str. Sakai 913870 NP_309519.1 CDS ECs1492 NC_002695.1 1529643 1533089 R similar to MFD_ECOLI gi|1787357 (conserved in Escherichia coli K-12); transcription-repair coupling factor complement(1529643..1533089) Escherichia coli O157:H7 str. Sakai 913354 NP_309520.1 CDS ECs1493 NC_002695.1 1533217 1534290 R similar to YCFT_ECOLI gi|1787359 (conserved in Escherichia coli K-12); hypothetical protein complement(1533217..1534290) Escherichia coli O157:H7 str. Sakai 912685 NP_309521.1 CDS ECs1494 NC_002695.1 1534552 1535751 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1534552..1535751 Escherichia coli O157:H7 str. Sakai 912675 NP_309522.2 CDS lolD NC_002695.1 1535744 1536445 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding protein 1535744..1536445 Escherichia coli O157:H7 str. Sakai 913145 NP_309523.1 CDS ECs1496 NC_002695.1 1536445 1537689 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1536445..1537689 Escherichia coli O157:H7 str. Sakai 913380 NP_309524.1 CDS ECs1497 NC_002695.1 1537718 1538629 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1537718..1538629 Escherichia coli O157:H7 str. Sakai 912695 NP_309525.1 CDS ECs1498 NC_002695.1 1538645 1539466 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1538645..1539466 Escherichia coli O157:H7 str. Sakai 913467 NP_309526.1 CDS potD NC_002695.1 1539622 1540668 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein complement(1539622..1540668) Escherichia coli O157:H7 str. Sakai 912995 NP_309527.1 CDS potC NC_002695.1 1540665 1541459 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1540665..1541459) Escherichia coli O157:H7 str. Sakai 912458 NP_309528.1 CDS ECs1501 NC_002695.1 1541626 1542744 R similar to integrase [Escherichia coli prophage e14] gi|3024035|sp|P75969|INTE_ECOLI; integrase complement(1541626..1542744) Escherichia coli O157:H7 str. Sakai 912447 NP_309529.1 CDS ECs1502 NC_002695.1 1542713 1542982 R similar to excisionase [bacteripohage P21] gi|139674|sp|P27079|VXIS_BPP21; excisionase complement(1542713..1542982) Escherichia coli O157:H7 str. Sakai 912339 NP_309530.1 CDS ECs1503 NC_002695.1 1543044 1543481 R hypothetical protein complement(1543044..1543481) Escherichia coli O157:H7 str. Sakai 912505 NP_309531.1 CDS ECs1504 NC_002695.1 1543524 1544081 D hypothetical protein 1543524..1544081 Escherichia coli O157:H7 str. Sakai 912890 NP_309532.1 CDS ECs1505 NC_002695.1 1544196 1544426 R similar to hypothetical protein YdfA [Escherichia coli] gi|140584|sp|P29008|YDFA_ECOLI; hypothetical protein complement(1544196..1544426) Escherichia coli O157:H7 str. Sakai 916937 NP_309533.1 CDS ECs1506 NC_002695.1 1544664 1545140 R similar to repressor [Escherichia col Rac prophage] gi|3025101|sp|P76062|RACR_ECOLI; phage repressor complement(1544664..1545140) Escherichia coli O157:H7 str. Sakai 912543 NP_309534.1 CDS ECs1507 NC_002695.1 1545265 1545588 D similar to YdaS [Escherichia coli] gi|3025102|sp|P76063|YDAS_ECOLI; hypothetical protein 1545265..1545588 Escherichia coli O157:H7 str. Sakai 914027 NP_309535.1 CDS ECs1508 NC_002695.1 1545572 1545997 D similar to YdaT [Escherichia coli] gi|3183265|sp|P76165|YDFX_ECOLI; hypothetical protein 1545572..1545997 Escherichia coli O157:H7 str. Sakai 912648 NP_309536.1 CDS ECs1509 NC_002695.1 1546066 1547103 D similar to replication termination protein DnaT (prepriming protein I) [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein 1546066..1547103 Escherichia coli O157:H7 str. Sakai 912911 NP_309537.1 CDS ECs1510 NC_002695.1 1546964 1547557 D similar to replication protein 14 [Bacteriophage phi-80] gi|137937|sp|P14814|VG14_BPPH8; replication protein 1546964..1547557 Escherichia coli O157:H7 str. Sakai 912993 NP_309538.1 CDS ECs1511 NC_002695.1 1547591 1548307 D similar to YdaW [Escherichia coli] gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein 1547591..1548307 Escherichia coli O157:H7 str. Sakai 913920 NP_309539.1 CDS ECs1512 NC_002695.1 1548304 1548621 D hypothetical protein 1548304..1548621 Escherichia coli O157:H7 str. Sakai 913655 NP_309540.1 CDS ECs1513 NC_002695.1 1548618 1548920 D similar to Gp57 [Bacteriophage N15] gi|7459176|pir||T13144; hypothetical protein 1548618..1548920 Escherichia coli O157:H7 str. Sakai 912435 NP_309541.1 CDS ECs1514 NC_002695.1 1548910 1549227 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881670|dbj|BAA84361.1|; hypothetical protein 1548910..1549227 Escherichia coli O157:H7 str. Sakai 912955 NP_309542.1 CDS ECs1515 NC_002695.1 1549181 1549498 D hypothetical protein 1549181..1549498 Escherichia coli O157:H7 str. Sakai 913221 NP_309543.1 CDS ECs1516 NC_002695.1 1549485 1549922 D similar to hypothetical protein Ea22 [Bacteriophage lambda] gi|137663|sp|P03756|VE22_LAMBD; hypothetical protein 1549485..1549922 Escherichia coli O157:H7 str. Sakai 913799 NP_309544.1 CDS ECs1517 NC_002695.1 1549924 1550115 D hypothetical protein 1549924..1550115 Escherichia coli O157:H7 str. Sakai 913272 NP_309545.1 CDS ECs1518 NC_002695.1 1550118 1550705 D similar to hypothetical protein b2363 [Escherichia coli] H65009, hypothetical protein Bacteriophage 933W AAD25410; hypothetical protein 1550118..1550705 Escherichia coli O157:H7 str. Sakai 912480 NP_309547.1 CDS ECs1520 NC_002695.1 1551114 1551326 D similar to Hok/Gef family e.g. MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76; prophage maintenance protein 1551114..1551326 Escherichia coli O157:H7 str. Sakai 913183 NP_309548.1 CDS ECs1521 NC_002695.1 1551494 1551772 D similar to QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1; hypothetical protein 1551494..1551772 Escherichia coli O157:H7 str. Sakai 912325 NP_309549.1 CDS ECs1522 NC_002695.1 1551774 1552823 D similar to b1560 [Escherichia coli] gi|1742555|dbj|BAA15259.1, hypothetical protein A [phage P1] gi|732234|sp|Q06262|YORA_BPP1; hypothetical protein 1551774..1552823 Escherichia coli O157:H7 str. Sakai 912865 NP_309550.1 CDS ECs1523 NC_002695.1 1552836 1553210 D similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1, crossover junction endodeoxyribonucleases Rus [Escherichia coli cryptic lambdoid prophage DLP12; crossover junction endodeoxyribonuclease 1552836..1553210 Escherichia coli O157:H7 str. Sakai 912345 NP_309551.1 CDS ECs1524 NC_002695.1 1553207 1554028 D similar to antitermination protein protein Q [Escherichia coli] gi|1742554|dbj|BAA15258.1; antitermination protein 1553207..1554028 Escherichia coli O157:H7 str. Sakai 912958 NP_309552.1 CDS ECs1526 NC_002695.1 1554441 1554941 R hypothetical protein complement(1554441..1554941) Escherichia coli O157:H7 str. Sakai 913386 NP_309553.1 CDS ECs1525 NC_002695.1 1554893 1555078 D hypothetical protein 1554893..1555078 Escherichia coli O157:H7 str. Sakai 913385 NP_309554.1 CDS ECs1527 NC_002695.1 1555107 1557044 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881634|dbj|BAA84325.1; hypothetical protein 1555107..1557044 Escherichia coli O157:H7 str. Sakai 913384 NP_309555.1 CDS ECs1528 NC_002695.1 1557192 1557374 D similar to hypothetical protein [Bacteriophage 933W] gi|4499806|emb|CAB39305.1; hypothetical protein 1557192..1557374 Escherichia coli O157:H7 str. Sakai 913383 NP_309556.1 CDS ECs1529 NC_002695.1 1557412 1557681 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881635|dbj|BAA84326.1; hypothetical protein 1557412..1557681 Escherichia coli O157:H7 str. Sakai 913382 NP_309557.1 CDS ECs1530 NC_002695.1 1557757 1557972 D similar to holin S protein [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1; holin 1557757..1557972 Escherichia coli O157:H7 str. Sakai 913381 NP_309558.1 CDS ECs1531 NC_002695.1 1557977 1558321 D similar to YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 1557977..1558321 Escherichia coli O157:H7 str. Sakai 913379 NP_309559.1 CDS ECs1532 NC_002695.1 1558372 1558905 D similar to R protein [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin 1558372..1558905 Escherichia coli O157:H7 str. Sakai 913378 NP_309560.1 CDS ECs1533 NC_002695.1 1559176 1559745 D similar to antirepressor protein [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1559176..1559745 Escherichia coli O157:H7 str. Sakai 913377 NP_309561.1 CDS ECs1534 NC_002695.1 1559899 1560366 D host cell lysis; similar to endopeptidases e.g. Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1; endopeptidase 1559899..1560366 Escherichia coli O157:H7 str. Sakai 913375 NP_309563.1 CDS ECs1536 NC_002695.1 1560390 1560614 D hypothetical protein 1560390..1560614 Escherichia coli O157:H7 str. Sakai 913372 NP_309564.1 CDS ECs1537 NC_002695.1 1560611 1560829 D similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881640|dbj|BAA84331.1; hypothetical protein 1560611..1560829 Escherichia coli O157:H7 str. Sakai 913371 NP_309565.1 CDS ECs1538 NC_002695.1 1560971 1561111 D hypothetical protein 1560971..1561111 Escherichia coli O157:H7 str. Sakai 913370 NP_309566.1 CDS ECs1539 NC_002695.1 1561241 1561426 R similar to hypothetical proteins [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein complement(1561241..1561426) Escherichia coli O157:H7 str. Sakai 913367 NP_309567.1 CDS ECs1540 NC_002695.1 1561468 1561833 D similar to DNAse [Bacteriophage phi-31] gi|1107475|emb|CAA62587.1; Dnase 1561468..1561833 Escherichia coli O157:H7 str. Sakai 913366 NP_944519.1 CDS ECs5417 NC_002695.1 1561486 1561731 R hypothetical protein complement(1561486..1561731) Escherichia coli O157:H7 str. Sakai 2693789 NP_309568.1 CDS ECs1541 NC_002695.1 1562123 1562686 D similar to terminase small subunit [Bacillus subtilis PBSX phage] gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 1562123..1562686 Escherichia coli O157:H7 str. Sakai 913365 NP_309569.1 CDS ECs1542 NC_002695.1 1562683 1564344 D similar to hypothetical protein phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; large terminase subunit 1562683..1564344 Escherichia coli O157:H7 str. Sakai 913364 NP_309570.1 CDS ECs1543 NC_002695.1 1564408 1566345 D similar to prohead protease Gp4 [Bacteriophage HK97] gi|1722780|sp|P49860|VP4_BPHK7; major head protein/prohead proteinase 1564408..1566345 Escherichia coli O157:H7 str. Sakai 913361 NP_944520.1 CDS ECs5418 NC_002695.1 1566390 1566611 D hypothetical protein 1566390..1566611 Escherichia coli O157:H7 str. Sakai 2693796 NP_309571.1 CDS ECs1544 NC_002695.1 1566557 1569058 D similar to portal protein [Bacteriophage HK022] gi|6863114|gb|AAF30355.1|AF069308_3; portal protein 1566557..1569058 Escherichia coli O157:H7 str. Sakai 913360 NP_309572.1 CDS ECs1545 NC_002695.1 1569138 1569464 D hypothetical protein 1569138..1569464 Escherichia coli O157:H7 str. Sakai 913359 NP_309573.1 CDS ECs1546 NC_002695.1 1569474 1569824 D similar to head-tail adaptor [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adapotor 1569474..1569824 Escherichia coli O157:H7 str. Sakai 913357 NP_309574.1 CDS ECs1547 NC_002695.1 1569821 1570267 D similar to hypothetical phage protein Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 1569821..1570267 Escherichia coli O157:H7 str. Sakai 913356 NP_309575.1 CDS ECs1548 NC_002695.1 1570264 1570608 D similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 1570264..1570608 Escherichia coli O157:H7 str. Sakai 913355 NP_309576.1 CDS ECs1549 NC_002695.1 1570667 1571383 D similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail subunit 1570667..1571383 Escherichia coli O157:H7 str. Sakai 913353 NP_309577.1 CDS ECs1550 NC_002695.1 1571389 1571763 D similar to tail assembly chaperone Gp14 [Bacteriophage HK97] gi|6901600|gb|AAF31103.1; tail assembly chaperone 1571389..1571763 Escherichia coli O157:H7 str. Sakai 913352 NP_309578.1 CDS ECs1551 NC_002695.1 1571787 1572068 D similar to Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1; may be produced by translational frameshift; phage tail protein 1571787..1572068 Escherichia coli O157:H7 str. Sakai 913351 NP_309581.1 CDS ECs1554 NC_002695.1 1575357 1575698 D similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1575357..1575698 Escherichia coli O157:H7 str. Sakai 913347 NP_309582.1 CDS ECs1555 NC_002695.1 1575698 1576396 D similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1575698..1576396 Escherichia coli O157:H7 str. Sakai 913344 NP_309583.1 CDS ECs1556 NC_002695.1 1576413 1576667 R similar to regulatory protein Mnt[Bacteriophage P22] gi|133138|sp|P03049|RMNT_BPP22; regulatory protein complement(1576413..1576667) Escherichia coli O157:H7 str. Sakai 913343 NP_309584.1 CDS ECs1557 NC_002695.1 1577190 1578068 D similar to antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1577190..1578068 Escherichia coli O157:H7 str. Sakai 913341 NP_309585.1 CDS ECs1558 NC_002695.1 1578122 1578859 D similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 1578122..1578859 Escherichia coli O157:H7 str. Sakai 913340 NP_309586.1 CDS ECs1559 NC_002695.1 1578757 1579041 D similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1578757..1579041 Escherichia coli O157:H7 str. Sakai 913339 NP_309587.1 CDS ECs1560 NC_002695.1 1579163 1581511 D similar to secreted effector protein SopA [Salmonella dublin] gi|5669806|gb|AAD46479.1|AF121227_1; secreted effector protein 1579163..1581511 Escherichia coli O157:H7 str. Sakai 913338 NP_309588.1 CDS ECs1561 NC_002695.1 1582102 1585503 D similar to cytotoxic necrotizing factor type 2 [Escherichia coli] gi|1073353|pir||A55260; hypothetical protein 1582102..1585503 Escherichia coli O157:H7 str. Sakai 913337 NP_309591.1 CDS ECs1564 NC_002695.1 1586046 1586951 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1586046..1586951) Escherichia coli O157:H7 str. Sakai 913334 NP_309592.1 CDS ECs1565 NC_002695.1 1587113 1587274 R OrfA; similar to hypothetical protein [insertion sequence IS2] gi|140806|sp|P19776|YI21_ECOLI; transposase complement(1587113..1587274) Escherichia coli O157:H7 str. Sakai 913333 NP_944521.1 CDS ECs5419 NC_002695.1 1587285 1587584 D hypothetical protein 1587285..1587584 Escherichia coli O157:H7 str. Sakai 2693776 NP_309594.1 CDS ECs1567 NC_002695.1 1587812 1588087 R hypothetical protein complement(1587812..1588087) Escherichia coli O157:H7 str. Sakai 913331 NP_309595.1 CDS ECs1568 NC_002695.1 1588148 1589509 R similar to Yop effector YopM [Yersinia enterocolitica] gi|4324334|gb|AAD16811.1; hypothetical protein complement(1588148..1589509) Escherichia coli O157:H7 str. Sakai 913330 NP_309596.1 CDS ECs1569 NC_002695.1 1589630 1589842 R hypothetical protein complement(1589630..1589842) Escherichia coli O157:H7 str. Sakai 913329 NP_309597.1 CDS potB NC_002695.1 1589873 1590736 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1589873..1590736) Escherichia coli O157:H7 str. Sakai 913328 NP_309598.1 CDS potA NC_002695.1 1590720 1591856 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase complement(1590720..1591856) Escherichia coli O157:H7 str. Sakai 913327 NP_309599.1 CDS ECs1572 NC_002695.1 1592106 1593332 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1592106..1593332 Escherichia coli O157:H7 str. Sakai 913326 NP_309600.2 CDS ECs1573 NC_002695.1 1593381 1594502 R similar to YCFD_ECOLI gi|1787373 (conserved in Escherichia coli K-12); hypothetical protein complement(1593381..1594502) Escherichia coli O157:H7 str. Sakai 913325 NP_309601.1 CDS ECs1574 NC_002695.1 1594751 1595980 D similar to integrases e.g. [Shigella dysenteriae] gi|6759954|gb|AAF28112.1|AF153317_4; integrase 1594751..1595980 Escherichia coli O157:H7 str. Sakai 913324 NP_309603.1 CDS ECs1576 NC_002695.1 1596591 1597334 D hypothetical protein 1596591..1597334 Escherichia coli O157:H7 str. Sakai 913322 NP_944522.1 CDS ECs5420 NC_002695.1 1597034 1597165 R hypothetical protein complement(1597034..1597165) Escherichia coli O157:H7 str. Sakai 2693777 NP_309604.1 CDS ECs1577 NC_002695.1 1597360 1597557 D probable cell division repressor; similar to cell division repressor Icd [enterobacteria phage P1] gi|4261623|gb|AAD13923.1|S61175_1; Icd-like protein 1597360..1597557 Escherichia coli O157:H7 str. Sakai 913321 NP_309605.1 CDS ECs1578 NC_002695.1 1597550 1597735 D hypothetical protein 1597550..1597735 Escherichia coli O157:H7 str. Sakai 913320 NP_309606.1 CDS ECs1579 NC_002695.1 1597735 1597926 D hypothetical protein 1597735..1597926 Escherichia coli O157:H7 str. Sakai 913319 NP_309607.1 CDS ECs1580 NC_002695.1 1597916 1598158 D hypothetical protein 1597916..1598158 Escherichia coli O157:H7 str. Sakai 913318 NP_309608.1 CDS ECs1581 NC_002695.1 1598164 1598463 D hypothetical protein 1598164..1598463 Escherichia coli O157:H7 str. Sakai 913316 NP_309612.1 CDS ECs1585 NC_002695.1 1600591 1600935 R hypothetical protein complement(1600591..1600935) Escherichia coli O157:H7 str. Sakai 913312 NP_309613.1 CDS ECs1586 NC_002695.1 1600965 1601216 D hypothetical protein 1600965..1601216 Escherichia coli O157:H7 str. Sakai 913311 NP_309614.1 CDS ECs1587 NC_002695.1 1601213 1601623 D similar to single stranded DNA-binding proteins e.g. [Thermotoga maritima] gi|7439946|pir||H72354; single stranded DNA-binding protein 1601213..1601623 Escherichia coli O157:H7 str. Sakai 913309 NP_309615.1 CDS ECs1588 NC_002695.1 1601634 1601906 D similar to PerC (BfpW) transcriptional activator of eaeA/bfpA [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional activator 1601634..1601906 Escherichia coli O157:H7 str. Sakai 913308 NP_309616.2 CDS ECs1589 NC_002695.1 1601953 1602255 D hypothetical protein 1601953..1602255 Escherichia coli O157:H7 str. Sakai 913307 NP_309617.1 CDS ECs1590 NC_002695.1 1602548 1603705 D similar to major head proteins e.g. phage phi-C31 gp36-like protein [Haemophilus influenzae] gi|6739663|gb|AAF27364.1|AF198256_18 (AF198256); major head protein 1602548..1603705 Escherichia coli O157:H7 str. Sakai 913306 NP_309618.2 CDS ECs1591 NC_002695.1 1603745 1604317 D similar to prohead proteases e.g. phage phi-C31 gp35-like protein [Haemophilus influenzae] gi|6739662|gb|AAF27363.1|AF198256_17; prohead protease 1603745..1604317 Escherichia coli O157:H7 str. Sakai 913305 NP_309619.1 CDS ECs1592 NC_002695.1 1604319 1605530 D similar to head portal proteins e.g. phage phi-105 ORF25-like protein [Haemophilus influenzae]gi|6739661|gb|AAF27362.1|AF198256_ 16; head portal protein 1604319..1605530 Escherichia coli O157:H7 str. Sakai 913303 NP_309620.1 CDS ECs1593 NC_002695.1 1605527 1605865 D similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 1605527..1605865 Escherichia coli O157:H7 str. Sakai 913301 NP_309621.1 CDS ECs1594 NC_002695.1 1605862 1606158 D similar to hypothetical protein [Haemophilus influenzae] gi|6739659|gb|AAF27360.1|AF198256_14, hypothetical protein 30 [Bacillus phage phi-105] gi|7459182|pir||T13519; hypothetical protein 1605862..1606158 Escherichia coli O157:H7 str. Sakai 913302 NP_309622.1 CDS ECs1595 NC_002695.1 1606158 1606598 D similar to hypothetical protein [Haemophilus influenzae] gi|6739658|gb|AAF27359.1|AF198256_13; hypothetical protein 1606158..1606598 Escherichia coli O157:H7 str. Sakai 913298 NP_309623.1 CDS ECs1596 NC_002695.1 1606591 1606764 D hypothetical protein 1606591..1606764 Escherichia coli O157:H7 str. Sakai 913297 NP_309624.1 CDS ECs1597 NC_002695.1 1606888 1607244 D similar to hypothetical protein of genetic island 1 [Haemophilus influenzae] gi|6739657|gb|AAF27358.1|AF198256_12; terminase small subunit 1606888..1607244 Escherichia coli O157:H7 str. Sakai 913296 NP_309625.1 CDS ECs1598 NC_002695.1 1607228 1608889 D similar to terminase large subunits e.g.[Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 1607228..1608889 Escherichia coli O157:H7 str. Sakai 913294 NP_309626.1 CDS ECs1599 NC_002695.1 1608903 1609184 D hypothetical protein 1608903..1609184 Escherichia coli O157:H7 str. Sakai 913293 NP_309628.1 CDS ECs1601 NC_002695.1 1610041 1611501 R sensor protein; similar to PHOQ_ECOLI gi|1787374 (conserved in Escherichia coli K-12); sensor protein PhoQ complement(1610041..1611501) Escherichia coli O157:H7 str. Sakai 913290 NP_309629.1 CDS ECs1602 NC_002695.1 1611501 1612172 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; PhoP family transcriptional regulator complement(1611501..1612172) Escherichia coli O157:H7 str. Sakai 913289 NP_309630.1 CDS ECs1603 NC_002695.1 1612341 1613711 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1612341..1613711) Escherichia coli O157:H7 str. Sakai 913288 NP_309631.1 CDS ECs1604 NC_002695.1 1613715 1614356 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1613715..1614356) Escherichia coli O157:H7 str. Sakai 913287 NP_309632.2 CDS mnmA NC_002695.1 1614392 1615498 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1614392..1615498) Escherichia coli O157:H7 str. Sakai 913286 NP_309633.1 CDS ECs1606 NC_002695.1 1615552 1616013 R similar to B1134_ECOLI gi|1787379 (conserved in Escherichia coli K-12); phosphohydrolase complement(1615552..1616013) Escherichia coli O157:H7 str. Sakai 913284 NP_309634.2 CDS ECs1607 NC_002695.1 1616023 1616646 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1616023..1616646) Escherichia coli O157:H7 str. Sakai 913282 NP_309635.1 CDS ECs1608 NC_002695.1 1616848 1618098 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1616848..1618098 Escherichia coli O157:H7 str. Sakai 913281 NP_309636.1 CDS ECs1609 NC_002695.1 1618212 1619354 R similar to integrase [Bacteriophage P21] gi|138558|sp|P27077|VINT_BPP21; intergrase complement(1618212..1619354) Escherichia coli O157:H7 str. Sakai 913280 NP_309637.1 CDS ECs1610 NC_002695.1 1619344 1619580 R similar to excisionase [Bacteriophage P21] gi|139674|sp|P27079|VXIS_BPP21; excisionase complement(1619344..1619580) Escherichia coli O157:H7 str. Sakai 913279 NP_309638.1 CDS ECs1611 NC_002695.1 1619684 1620508 D similar to replication protein GpO [Bacteriophage lambda] gi|215150|gb|AAA96584.1; replication protein 1619684..1620508 Escherichia coli O157:H7 str. Sakai 913278 NP_309639.1 CDS ECs1612 NC_002695.1 1620505 1621206 D similar to replication protein GpP [Bacteriophage lambda] gi|4499785|emb|CAB39284.1; replication protein P 1620505..1621206 Escherichia coli O157:H7 str. Sakai 913277 NP_309640.1 CDS ECs1613 NC_002695.1 1621203 1621505 D similar to Ren protein [Bacteriophage lambda] gi|139473|sp|P03761|VREN_LAMBD; Ren protein 1621203..1621505 Escherichia coli O157:H7 str. Sakai 913276 NP_309641.1 CDS emrE NC_002695.1 1621573 1621905 D member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 1621573..1621905 Escherichia coli O157:H7 str. Sakai 913273 NP_309642.1 CDS ECs1615 NC_002695.1 1622150 1623676 D similar to hypothetical protein YbcK [Escherichia coli] gi|2495549|sp|P77698|YBCK_ECOLI, integrase [Bacteriophage A118] gi|1196324|gb|AAB51416.1; hypothetical protein 1622150..1623676 Escherichia coli O157:H7 str. Sakai 913275 NP_309643.1 CDS ECs1616 NC_002695.1 1624178 1624633 D DLP12 prophage; hypothetical protein 1624178..1624633 Escherichia coli O157:H7 str. Sakai 913271 NP_309644.1 CDS ECs1617 NC_002695.1 1624633 1624803 D DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 1624633..1624803 Escherichia coli O157:H7 str. Sakai 913270 NP_309645.1 CDS ECs1618 NC_002695.1 1624796 1625086 D similar to YbcO [Escherichia coli cryptic prophage DLP12] gi|2495553|sp|Q47271|YBCO_ECOLI, Gp66 [Bacteriophage HK97] gi|6901638|gb|AAF31141.1; hypothetical protein 1624796..1625086 Escherichia coli O157:H7 str. Sakai 913269 NP_309646.1 CDS ECs1619 NC_002695.1 1625083 1625445 D DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 1625083..1625445 Escherichia coli O157:H7 str. Sakai 913268 NP_944523.1 CDS ECs5421 NC_002695.1 1625442 1625582 D hypothetical protein 1625442..1625582 Escherichia coli O157:H7 str. Sakai 2693778 NP_309647.1 CDS ECs1620 NC_002695.1 1625579 1626268 D similar to antitermination proteins e.g. Q [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; antitermination protein 1625579..1626268 Escherichia coli O157:H7 str. Sakai 913267 NP_309648.1 CDS ECs1621 NC_002695.1 1626578 1626895 D similar to holin [Bacteriophage PS3] gi|3676074|emb|CAA09700.1|; holin 1626578..1626895 Escherichia coli O157:H7 str. Sakai 913264 NP_309649.1 CDS ECs1622 NC_002695.1 1626882 1627358 D lyzozyme; similar to endolysins e.g. [Bacteriophage HK97] gi|6901642|gb|AAF31145.1; endolysin 1626882..1627358 Escherichia coli O157:H7 str. Sakai 913262 NP_309650.1 CDS ECs1623 NC_002695.1 1627355 1627816 D host cell lysis; similar to endopeptidases e.g. [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 1627355..1627816 Escherichia coli O157:H7 str. Sakai 913261 NP_309651.1 CDS ECs1624 NC_002695.1 1627575 1627757 D similar to Rs1 precursors e.g. [Bacteriophage lambda] gi|540738|pir||JN0750; lipoprotein Rz1 1627575..1627757 Escherichia coli O157:H7 str. Sakai 913259 NP_309652.1 CDS ECs1625 NC_002695.1 1627848 1628141 R similar to Bor protein precursor [Bacteriophage lambda] gi|137520|sp|P26814|VBOR_LAMBD; Bor protein complement(1627848..1628141) Escherichia coli O157:H7 str. Sakai 913257 NP_309653.1 CDS ECs1626 NC_002695.1 1628433 1628885 R similar to hypothetical protein YbcV [Escherichia coli] gi|2495556|sp|P77598|YBCV_ECOLI; hypothetical protein complement(1628433..1628885) Escherichia coli O157:H7 str. Sakai 913256 NP_309654.1 CDS ECs1627 NC_002695.1 1629129 1629335 D similar to YbcW [Escherichia coli] gi|2495557|sp|P75720|YBCW_ECOLI; hypothetical protein 1629129..1629335 Escherichia coli O157:H7 str. Sakai 913255 NP_309655.1 CDS ECs1628 NC_002695.1 1629500 1629694 R similar to hypothetical protein Escherichia coli AAB40755; hypothetical protein complement(1629500..1629694) Escherichia coli O157:H7 str. Sakai 913254 NP_309656.1 CDS ECs1629 NC_002695.1 1630083 1630628 D similar to terminase small subunits e.g. Nu1 [Bacteriophage lambda] gi|139026|sp|P03707|TERS_LAMBD; terminase small subunit 1630083..1630628 Escherichia coli O157:H7 str. Sakai 913253 NP_309657.1 CDS ECs1630 NC_002695.1 1630603 1632528 D similar to terminase large subunits e.g. protein A [Bacteriophage lambda] gi|137616|sp|P03708|TERL_LAMBD; terminase large subunit 1630603..1632528 Escherichia coli O157:H7 str. Sakai 913252 NP_309658.1 CDS ECs1631 NC_002695.1 1632525 1632731 D similar to head-to-tail joining proteins e.g. GpW [Bacteriophage lambda] gi|138415|sp|P03727|VHTJ_LAMBD; head-to-tail joining protein 1632525..1632731 Escherichia coli O157:H7 str. Sakai 913251 NP_309659.1 CDS ECs1632 NC_002695.1 1632728 1634329 D similar to portal proteins e.g. GpB [Bacteriophage lambda] gi|138762|sp|P03710|VMCB_LAMBD; portal protein 1632728..1634329 Escherichia coli O157:H7 str. Sakai 913249 NP_309660.1 CDS ECs1633 NC_002695.1 1634310 1635629 D similar to minor capsid protein e.g. proteins C [Bacteriophage lambda] gi|137565|sp|P03711|VCAC_LAMBD; minor capsid protein 1634310..1635629 Escherichia coli O157:H7 str. Sakai 913247 NP_309661.1 CDS ECs1634 NC_002695.1 1635639 1635971 D similar to major capsid proteins e.g. GpD [Bacteriophage lambda] gi|137566|sp|P03712|VCAD_LAMBD; major capsid protein 1635639..1635971 Escherichia coli O157:H7 str. Sakai 913245 NP_309662.1 CDS ECs1635 NC_002695.1 1636027 1637052 D similar to major capsid proteins e.g. GpE [Bacteriophage lambda] gi|116752|sp|P03713|HEAD_LAMBD; major capsid protein 1636027..1637052 Escherichia coli O157:H7 str. Sakai 913244 NP_309663.1 CDS ECs1636 NC_002695.1 1637094 1637492 D similar to DNA packaging proteins e.g. GpFI [Bacteriophage lambda] gi|139324|sp|P03709|VPF1_LAMBD; DNA packaging protein 1637094..1637492 Escherichia coli O157:H7 str. Sakai 913243 NP_309664.1 CDS ECs1637 NC_002695.1 1637504 1637857 D similar to minor capsid proteins e.g. GpFII [Bacteriophage lambda] gi|137575|sp|P03714|VCF2_LAMBD; minor capsid protein 1637504..1637857 Escherichia coli O157:H7 str. Sakai 913242 NP_309665.1 CDS ECs1638 NC_002695.1 1637869 1638447 D similar to minor tail proteins e.g. GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein 1637869..1638447 Escherichia coli O157:H7 str. Sakai 913240 NP_309666.1 CDS ECs1639 NC_002695.1 1638444 1638839 D similar to minor tail proteins e.g. GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein 1638444..1638839 Escherichia coli O157:H7 str. Sakai 913239 NP_309667.1 CDS ECs1640 NC_002695.1 1638847 1639587 D similar to major tail proteins e.g. GpV of [Bacteriophage lambda] gi|138848|sp|P03733|VMTV_LAMBD; major tail protein V 1638847..1639587 Escherichia coli O157:H7 str. Sakai 913238 NP_309668.1 CDS ECs1641 NC_002695.1 1639603 1640025 D similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 1639603..1640025 Escherichia coli O157:H7 str. Sakai 913237 NP_309669.1 CDS ECs1642 NC_002695.1 1640007 1640441 D similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein 1640007..1640441 Escherichia coli O157:H7 str. Sakai 913236 NP_309670.1 CDS ECs1643 NC_002695.1 1640434 1642983 D similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 1640434..1642983 Escherichia coli O157:H7 str. Sakai 913235 NP_309671.1 CDS ECs1644 NC_002695.1 1642980 1643309 D similar to minor tail proteins e.g. GpM of [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1642980..1643309 Escherichia coli O157:H7 str. Sakai 913234 NP_309672.1 CDS ECs1645 NC_002695.1 1643309 1644007 D similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1643309..1644007 Escherichia coli O157:H7 str. Sakai 913233 NP_309673.1 CDS ECs1646 NC_002695.1 1644013 1644756 D similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 1644013..1644756 Escherichia coli O157:H7 str. Sakai 913232 NP_309674.1 CDS ECs1647 NC_002695.1 1644654 1645325 D similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1644654..1645325 Escherichia coli O157:H7 str. Sakai 913231 NP_309675.1 CDS ECs1648 NC_002695.1 1645386 1648784 D similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1645386..1648784 Escherichia coli O157:H7 str. Sakai 913230 NP_309676.1 CDS ECs1649 NC_002695.1 1648851 1649450 D similar to membrane protein Lom precursors e.g. [prophage P-EibA gi|7532789|gb|AAF63231.1|AF151091_2, [Bacteriophage lambda] gi|138693|sp|P03701|VLOM_LAMBD; membrane protein 1648851..1649450 Escherichia coli O157:H7 str. Sakai 913229 NP_309677.1 CDS ECs1650 NC_002695.1 1649515 1652430 D similar to probable tail fiber proteins e.g. Gp37 [Escherichia coli] gi|7466858|pir||G64887; tail fiber protein 1649515..1652430 Escherichia coli O157:H7 str. Sakai 913228 NP_309678.1 CDS ECs1651 NC_002695.1 1652430 1653011 D similar to tail fiber assembly proteins e.g. Orf194 [Bacteriophage lambda] gi|139990|sp|P03740|Y194_LAMBD; tail fiber assembly protein 1652430..1653011 Escherichia coli O157:H7 str. Sakai 913227 NP_309679.1 CDS ECs1652 NC_002695.1 1653131 1654021 R similar to hypothetical proteins e.g. catalase [Salmonella typhimurium] gi|7162108|emb|CAB76676.1; catalase complement(1653131..1654021) Escherichia coli O157:H7 str. Sakai 913226 NP_309680.1 CDS ECs1653 NC_002695.1 1654040 1654546 R similar to hypothetical proteins e.g. YciE [Escherichia coli] gi|775201|gb|AAA65179.1; hypothetical protein complement(1654040..1654546) Escherichia coli O157:H7 str. Sakai 913225 NP_309681.1 CDS ECs1654 NC_002695.1 1654583 1655083 R similar to hypothetical proteins e.g. YciF [Escherichia coli] gi|140432|sp|P21362|YCIF_ECOLI; hypothetical protein complement(1654583..1655083) Escherichia coli O157:H7 str. Sakai 913224 NP_309682.1 CDS ECs1655 NC_002695.1 1655162 1655344 R similar to hypothetical proteins e.g. YciG-homolog [Salmonella typhimurium] gi|6851081|emb|CAB71036.1; hypothetical protein complement(1655162..1655344) Escherichia coli O157:H7 str. Sakai 913223 NP_309683.1 CDS ECs1656 NC_002695.1 1655842 1656273 R similar to hypothetical proteins e.g. ybcY [Escherichia coli] gi|2495559|sp|P77460|YBCY_ECOLI; hypothetical protein complement(1655842..1656273) Escherichia coli O157:H7 str. Sakai 913222 NP_309684.1 CDS ECs1657 NC_002695.1 1656567 1656815 D similar to hypothetical proteins e.g. YlcE [Escherichia coli] gi|3025212|sp|P77087|YLCE_ECOLI; hypothetical protein 1656567..1656815 Escherichia coli O157:H7 str. Sakai 913219 NP_309685.1 CDS ECs1658 NC_002695.1 1656891 1657271 D similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 EDL933] gi|3414881|gb|AAC31492.1; hypothetical protein 1656891..1657271 Escherichia coli O157:H7 str. Sakai 913218 NP_309686.1 CDS ECs1659 NC_002695.1 1657268 1657615 D similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 EDL933] gi|3414882|gb|AAC31493.1; hypothetical protein 1657268..1657615 Escherichia coli O157:H7 str. Sakai 913217 NP_309687.1 CDS ECs1660 NC_002695.1 1657665 1659203 D similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 EDL933] gi|3414883|gb|AAC31494.1; hypothetical protein 1657665..1659203 Escherichia coli O157:H7 str. Sakai 913216 NP_309689.1 CDS ECs1662 NC_002695.1 1659506 1660990 R similar to hypothetical protein [plasmid F] gi|8918853|dbj|BAA97900.1; hypothetical protein complement(1659506..1660990) Escherichia coli O157:H7 str. Sakai 913213 NP_309690.1 CDS ECs1663 NC_002695.1 1661177 1662130 R outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease complement(1661177..1662130) Escherichia coli O157:H7 str. Sakai 913212 NP_309691.1 CDS ECs1664 NC_002695.1 1662629 1663213 D similar to hypothetical proteins e.g. DNA binding protein [Streptomyces coelicolor A3(2)] gi|6855358|emb|CAB71249.1; hypothetical protein 1662629..1663213 Escherichia coli O157:H7 str. Sakai 913211 NP_309692.1 CDS ECs1665 NC_002695.1 1663387 1663713 D OrfA; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 1663387..1663713 Escherichia coli O157:H7 str. Sakai 913209 NP_309693.1 CDS ECs1666 NC_002695.1 1663710 1664600 D OrfB; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 1663710..1664600 Escherichia coli O157:H7 str. Sakai 913208 NP_309694.1 CDS ECs1667 NC_002695.1 1664690 1665394 D similar to hypothetical proteins e.g. part (1336-1569 in 1569 aa) of YPJA_ECOLI gi|2507221|sp|P52143; hypothetical protein 1664690..1665394 Escherichia coli O157:H7 str. Sakai 913207 NP_309695.1 CDS minE NC_002695.1 1665766 1666032 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1665766..1666032) Escherichia coli O157:H7 str. Sakai 913206 NP_309696.1 CDS ECs1669 NC_002695.1 1666036 1666848 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1666036..1666848) Escherichia coli O157:H7 str. Sakai 913204 NP_309697.1 CDS minC NC_002695.1 1666872 1667567 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1666872..1667567) Escherichia coli O157:H7 str. Sakai 913203 NP_309698.1 CDS ECs1671 NC_002695.1 1668087 1668455 D similar to YCGJ_ECOLI gi|1787425 (conserved in Escherichia coli K-12); hypothetical protein 1668087..1668455 Escherichia coli O157:H7 str. Sakai 913202 NP_309699.1 CDS ECs1672 NC_002695.1 1668558 1668959 R similar to YCGK_ECOLI gi|1787426 (conserved in Escherichia coli K-12); hypothetical protein complement(1668558..1668959) Escherichia coli O157:H7 str. Sakai 913201 NP_309700.1 CDS ECs1673 NC_002695.1 1668988 1669188 D hypothetical protein 1668988..1669188 Escherichia coli O157:H7 str. Sakai 913200 NP_309701.2 CDS ECs1674 NC_002695.1 1669200 1669493 D similar to YCGL_ECOLI gi|1787427 (conserved in Escherichia coli K-12); hypothetical protein 1669200..1669493 Escherichia coli O157:H7 str. Sakai 913199 NP_309702.1 CDS ECs1675 NC_002695.1 1669565 1670224 D similar to B1180_ECOLI gi|1787428 (conserved in Escherichia coli K-12); hypothetical protein 1669565..1670224 Escherichia coli O157:H7 str. Sakai 913198 NP_309703.3 CDS ECs1676 NC_002695.1 1670316 1670762 D similar to YCGN_ECOLI gi|1787429 (conserved in Escherichia coli K-12); hypothetical protein 1670316..1670762 Escherichia coli O157:H7 str. Sakai 913197 NP_309704.1 CDS hlyE NC_002695.1 1670969 1671886 R Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E complement(1670969..1671886) Escherichia coli O157:H7 str. Sakai 913196 NP_309705.1 CDS ECs1678 NC_002695.1 1672253 1672672 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1672253..1672672 Escherichia coli O157:H7 str. Sakai 913194 NP_309706.1 CDS umuC NC_002695.1 1672672 1673940 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1672672..1673940 Escherichia coli O157:H7 str. Sakai 913193 NP_309707.1 CDS ECs1680 NC_002695.1 1673986 1674516 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1673986..1674516) Escherichia coli O157:H7 str. Sakai 913192 NP_309708.1 CDS nhaB NC_002695.1 1674662 1676203 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1674662..1676203) Escherichia coli O157:H7 str. Sakai 913191 NP_309709.1 CDS ECs1682 NC_002695.1 1676425 1677144 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1676425..1677144 Escherichia coli O157:H7 str. Sakai 913189 NP_309710.1 CDS ECs1683 NC_002695.1 1677196 1678728 R similar to YCGB_ECOLI gi|1787437 (conserved in Escherichia coli K-12); SpoVR family protein complement(1677196..1678728) Escherichia coli O157:H7 str. Sakai 913188 NP_309711.1 CDS ECs1684 NC_002695.1 1679091 1680389 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1679091..1680389 Escherichia coli O157:H7 str. Sakai 913186 NP_309713.2 CDS ECs1686 NC_002695.1 1681862 1683598 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1681862..1683598) Escherichia coli O157:H7 str. Sakai 913182 NP_309714.1 CDS ldcA NC_002695.1 1683694 1684608 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1683694..1684608) Escherichia coli O157:H7 str. Sakai 913181 NP_309715.1 CDS ECs1687 NC_002695.1 1684594 1685319 D similar to MLTE_ECOLI gi|1787442 (conserved in Escherichia coli K-12); murein transglycosylase E 1684594..1685319 Escherichia coli O157:H7 str. Sakai 913179 NP_309716.1 CDS ECs1689 NC_002695.1 1685507 1686397 R OrfB; transposase insertion sequence IS629; similar to gi|7443862|pir|T00240; transposase complement(1685507..1686397) Escherichia coli O157:H7 str. Sakai 913178 NP_309717.1 CDS ECs1690 NC_002695.1 1686394 1686720 R OrfA; transposase insertion sequence IS629; similar to hypothetical proteins. e.g. [Shigella flexneri SHI-2 pathogenicity island] gi|5532454|gb|AAD44738.1|AF141323_9; transposase complement(1686394..1686720) Escherichia coli O157:H7 str. Sakai 913176 NP_309718.1 CDS ECs1691 NC_002695.1 1686772 1687368 R similar to f YCGR_ECOLI gi|1787443; hypothetical protein complement(1686772..1687368) Escherichia coli O157:H7 str. Sakai 913173 NP_309719.1 CDS ECs1692 NC_002695.1 1687569 1687823 D similar to YMGE_ECOLI gi|1787445 (conserved in Escherichia coli K-12); hypothetical protein 1687569..1687823 Escherichia coli O157:H7 str. Sakai 913172 NP_309720.1 CDS ECs1693 NC_002695.1 1687873 1689843 R similar to TonB dependent outer membrane receptor PrrA [Escherichia coli CFT073] gi|3661477|gb|AAC61709.1; TonB dependent outer membrane receptor complement(1687873..1689843) Escherichia coli O157:H7 str. Sakai 913171 NP_309721.1 CDS ECs1694 NC_002695.1 1689869 1690723 R involved in molybdenum transport; molybdenum transport protein ModD complement(1689869..1690723) Escherichia coli O157:H7 str. Sakai 913170 NP_309724.1 CDS ECs1697 NC_002695.1 1691542 1692300 R similar to ferric enterobactin transport ATP-binding protein [Escherichia coli CFT073] gi|3661480|gb|AAC61712.1; ferric enterobactin transport ATP-binding protein complement(1691542..1692300) Escherichia coli O157:H7 str. Sakai 913166 NP_309725.1 CDS ECs1698 NC_002695.1 1692297 1693277 R permease; similar to ABC transporter permeases e.g. [Haemophilus influenzae] gi|2501391|sp|Q57130|YE71_HAEIN; ABC transporter permease complement(1692297..1693277) Escherichia coli O157:H7 str. Sakai 913165 NP_309726.1 CDS ECs1699 NC_002695.1 1693277 1694299 R similar to iron (iii) ABC transporter, ATP-binding protein [Pyrococcus abyssi (strain Orsay)] gi|7519847|pir||A75077; ABC transporter ATP-binding protein complement(1693277..1694299) Escherichia coli O157:H7 str. Sakai 913164 NP_309727.1 CDS ECs1700 NC_002695.1 1694407 1694607 R hypothetical protein complement(1694407..1694607) Escherichia coli O157:H7 str. Sakai 913163 NP_309730.1 CDS ECs1703 NC_002695.1 1696639 1698060 R phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM complement(1696639..1698060) Escherichia coli O157:H7 str. Sakai 913160 NP_309731.1 CDS ECs1704 NC_002695.1 1698068 1698700 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(1698068..1698700) Escherichia coli O157:H7 str. Sakai 913159 NP_309732.3 CDS ECs1705 NC_002695.1 1698711 1699811 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1698711..1699811) Escherichia coli O157:H7 str. Sakai 913158 NP_309733.1 CDS ECs1706 NC_002695.1 1700000 1700476 D similar to B1201_ECOLI (DhaR) gi|1787451|P76016; hypothetical protein 1700000..1700476 Escherichia coli O157:H7 str. Sakai 913157 NP_309734.1 CDS ECs1707 NC_002695.1 1700116 1701759 R similar to adhesion and penetration protein B1202_ECOLI gi|1787452 (conserved in Escherichia coli K-12); hypothetical protein complement(1700116..1701759) Escherichia coli O157:H7 str. Sakai 913156 NP_944524.1 CDS ECs5422 NC_002695.1 1702104 1702307 D hypothetical protein 1702104..1702307 Escherichia coli O157:H7 str. Sakai 2693757 NP_309735.1 CDS ECs1708 NC_002695.1 1702603 1703694 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1702603..1703694) Escherichia coli O157:H7 str. Sakai 913155 NP_309736.1 CDS ECs1709 NC_002695.1 1703811 1704395 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1703811..1704395) Escherichia coli O157:H7 str. Sakai 913154 NP_309737.1 CDS ECs1710 NC_002695.1 1704673 1704951 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1704673..1704951 Escherichia coli O157:H7 str. Sakai 913153 NP_309738.1 CDS ECs1711 NC_002695.1 1705006 1706658 R role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM complement(1705006..1706658) Escherichia coli O157:H7 str. Sakai 913152 NP_309739.1 CDS ECs1712 NC_002695.1 1706810 1707757 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1706810..1707757) Escherichia coli O157:H7 str. Sakai 913151 NP_309740.1 CDS ipk NC_002695.1 1707908 1708759 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1707908..1708759) Escherichia coli O157:H7 str. Sakai 913150 NP_309741.1 CDS lolB NC_002695.1 1708759 1709382 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1708759..1709382) Escherichia coli O157:H7 str. Sakai 913149 NP_309742.1 CDS hemA NC_002695.1 1709596 1710852 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1709596..1710852 Escherichia coli O157:H7 str. Sakai 913148 NP_309743.1 CDS prfA NC_002695.1 1710894 1711976 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1710894..1711976 Escherichia coli O157:H7 str. Sakai 913147 NP_309744.1 CDS ECs1717 NC_002695.1 1711976 1712809 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1711976..1712809 Escherichia coli O157:H7 str. Sakai 913144 NP_309745.1 CDS ECs1718 NC_002695.1 1712806 1713198 D similar to B1213_ECOLI gi|1787464 (conserved in Escherichia coli K-12); transcriptional regulator 1712806..1713198 Escherichia coli O157:H7 str. Sakai 913143 NP_309746.1 CDS ECs1719 NC_002695.1 1713202 1714011 D similar to YCHA_ECOLI gi|1787465 (conserved in Escherichia coli K-12); transcriptional regulator 1713202..1714011 Escherichia coli O157:H7 str. Sakai 913142 NP_309747.1 CDS ECs1720 NC_002695.1 1714047 1714901 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1714047..1714901 Escherichia coli O157:H7 str. Sakai 913141 NP_309748.1 CDS ECs1721 NC_002695.1 1716091 1717191 R similar to CHAA_ECOLI gi|1787468 (conserved in Escherichia coli K-12); calcium/sodium:proton antiporter complement(1716091..1717191) Escherichia coli O157:H7 str. Sakai 913140 NP_309749.1 CDS chaB NC_002695.1 1717461 1717691 D in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1717461..1717691 Escherichia coli O157:H7 str. Sakai 913139 NP_309750.1 CDS ECs1723 NC_002695.1 1717828 1718547 D similar to CHAC_ECOLI gi|1787470 (conserved in Escherichia coli K-12); cation transport regulator 1717828..1718547 Escherichia coli O157:H7 str. Sakai 913138 NP_309751.1 CDS ECs1724 NC_002695.1 1718591 1718944 R similar to YCHN_ECOLI gi|1787471 (conserved in Escherichia coli K-12); hypothetical protein complement(1718591..1718944) Escherichia coli O157:H7 str. Sakai 913137 NP_309752.1 CDS ECs1725 NC_002695.1 1719271 1720524 D similar to YCHP_ECOLI gi|1787472 (conserved in Escherichia coli K-12); hypothetical protein 1719271..1720524 Escherichia coli O157:H7 str. Sakai 913136 NP_309753.1 CDS ECs1726 NC_002695.1 1720525 1721175 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1720525..1721175) Escherichia coli O157:H7 str. Sakai 913135 NP_309754.1 CDS ECs1727 NC_002695.1 1721168 1722964 R similar to NARX_ECOLI gi|1787474 (conserved in Escherichia coli K-12); nitrate/nitrite sensor protein NarX complement(1721168..1722964) Escherichia coli O157:H7 str. Sakai 913134 NP_944525.1 CDS ECs5423 NC_002695.1 1722990 1723208 D hypothetical protein 1722990..1723208 Escherichia coli O157:H7 str. Sakai 2693758 NP_309755.1 CDS ECs1728 NC_002695.1 1723303 1724694 D similar to NARK_ECOLI gi|1787475 (conserved in Escherichia coli K-12); nitrite extrusion protein 1723303..1724694 Escherichia coli O157:H7 str. Sakai 913133 NP_309756.1 CDS ECs1729 NC_002695.1 1725087 1728830 D similar to NARG_ECOLI gi|1787477 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit alpha 1725087..1728830 Escherichia coli O157:H7 str. Sakai 913132 NP_309757.1 CDS ECs1730 NC_002695.1 1728827 1730365 D similar to NARH_ECOLI gi|1787478 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit beta 1728827..1730365 Escherichia coli O157:H7 str. Sakai 913131 NP_309758.1 CDS ECs1731 NC_002695.1 1730362 1731072 D similar to NARJ_ECOLI gi|1787479 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit delta 1730362..1731072 Escherichia coli O157:H7 str. Sakai 913130 NP_309759.1 CDS ECs1732 NC_002695.1 1731072 1731749 D similar to NARI_ECOLI gi|1787480 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit gamma 1731072..1731749 Escherichia coli O157:H7 str. Sakai 913128 NP_309760.1 CDS ECs1733 NC_002695.1 1731932 1732207 D similar to B1228_ECOLI gi|1787481 (conserved in Escherichia coli K-12); hypothetical protein 1731932..1732207 Escherichia coli O157:H7 str. Sakai 913127 NP_309761.1 CDS purU NC_002695.1 1732827 1733669 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1732827..1733669) Escherichia coli O157:H7 str. Sakai 913121 NP_309762.1 CDS ECs1735 NC_002695.1 1733719 1734177 R similar to YCHJ_ECOLI gi|1787484 (conserved in Escherichia coli K-12); hypothetical protein complement(1733719..1734177) Escherichia coli O157:H7 str. Sakai 913117 NP_309763.1 CDS ECs1736 NC_002695.1 1734251 1735195 D similar to YCHK_ECOLI gi|1787485 (conserved in Escherichia coli K-12); hypothetical protein 1734251..1735195 Escherichia coli O157:H7 str. Sakai 913116 NP_309764.1 CDS ECs1737 NC_002695.1 1735287 1736300 D similar to HNR_ECOLI gi|1787487 (conserved in Escherichia coli K-12); response regulator of RpoS 1735287..1736300 Escherichia coli O157:H7 str. Sakai 913115 NP_309765.1 CDS ECs1738 NC_002695.1 1736502 1737410 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1736502..1737410 Escherichia coli O157:H7 str. Sakai 913114 NP_309766.1 CDS ECs1739 NC_002695.1 1737554 1737967 R similar to HNS_ECOLI gi|1787489 (conserved in Escherichia coli K-12); global DNA-binding transcriptional dual regulator H-NS complement(1737554..1737967) Escherichia coli O157:H7 str. Sakai 913113 NP_309767.1 CDS ECs1740 NC_002695.1 1738571 1739188 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1738571..1739188 Escherichia coli O157:H7 str. Sakai 913112 NP_309768.1 CDS ECs1741 NC_002695.1 1739489 1742164 R similar to ADHE_ECOLI gi|1787493 (conserved in Escherichia coli K-12); bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1739489..1742164) Escherichia coli O157:H7 str. Sakai 913110 NP_309769.1 CDS ECs1742 NC_002695.1 1742641 1743288 D similar to YCHE_ECOLI gi|1787494 (conserved in Escherichia coli K-12); hypothetical protein 1742641..1743288 Escherichia coli O157:H7 str. Sakai 913109 NP_309770.1 CDS ECs1743 NC_002695.1 1744026 1745657 D similar to OPPA_ECOLI gi|1787495 (conserved in Escherichia coli K-12); oligopeptide transport periplasmic binding protein 1744026..1745657 Escherichia coli O157:H7 str. Sakai 913108 NP_309771.1 CDS oppB NC_002695.1 1745743 1746663 D similar to OPPB_ECOLI gi|1787497 (conserved in Escherichia coli K-12); oligopeptide transporter permease 1745743..1746663 Escherichia coli O157:H7 str. Sakai 913107 NP_309772.1 CDS ECs1745 NC_002695.1 1746678 1747586 D similar to OPPC_ECOLI gi|1787498 (conserved in Escherichia coli K-12); hypothetical protein 1746678..1747586 Escherichia coli O157:H7 str. Sakai 913106 NP_309773.1 CDS oppD NC_002695.1 1747598 1748611 D similar to OPPD_ECOLI gi|1787499 (conserved in Escherichia coli K-12); oligopeptide ABC transporter ATP-binding protein 1747598..1748611 Escherichia coli O157:H7 str. Sakai 913105 NP_309774.1 CDS ECs1747 NC_002695.1 1748608 1749612 D similar to OPPF_ECOLI gi|1787500 (conserved in Escherichia coli K-12); hypothetical protein 1748608..1749612 Escherichia coli O157:H7 str. Sakai 913104 NP_309775.2 CDS ECs1748 NC_002695.1 1749665 1749994 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1749665..1749994) Escherichia coli O157:H7 str. Sakai 913103 NP_309776.1 CDS cls NC_002695.1 1750029 1751489 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1750029..1751489) Escherichia coli O157:H7 str. Sakai 913102 NP_944526.1 CDS ECs5426 NC_002695.1 1751521 1751805 D hypothetical protein 1751521..1751805 Escherichia coli O157:H7 str. Sakai 2693742 NP_309777.1 CDS ECs1750 NC_002695.1 1751860 1753113 R similar to KCH_ECOLI gi|1787503 (conserved in Escherichia coli K-12); voltage-gated potassium channel complement(1751860..1753113) Escherichia coli O157:H7 str. Sakai 913101 NP_309778.2 CDS ECs1751 NC_002695.1 1753414 1753710 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein complement(1753414..1753710) Escherichia coli O157:H7 str. Sakai 913100 NP_309779.1 CDS ECs1752 NC_002695.1 1753934 1754653 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1753934..1754653 Escherichia coli O157:H7 str. Sakai 913099 NP_309780.1 CDS ECs1753 NC_002695.1 1754693 1755091 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase complement(1754693..1755091) Escherichia coli O157:H7 str. Sakai 913098 NP_309781.1 CDS ECs1754 NC_002695.1 1755196 1755735 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1755196..1755735) Escherichia coli O157:H7 str. Sakai 913097 NP_309782.1 CDS ECs1755 NC_002695.1 1755765 1756508 R similar to YCIC_ECOLI gi|1787508 (conserved in Escherichia coli K-12); hypothetical protein complement(1755765..1756508) Escherichia coli O157:H7 str. Sakai 913096 NP_309783.1 CDS ECs1756 NC_002695.1 1756865 1757503 D receptor for colicin S4; outer membrane protein W 1756865..1757503 Escherichia coli O157:H7 str. Sakai 913095 NP_309784.1 CDS ECs1757 NC_002695.1 1757549 1758679 R similar to phage integrase [Bacteriophage 21] gi|138558|sp|P27077|VINT_BPP21; integrase complement(1757549..1758679) Escherichia coli O157:H7 str. Sakai 913094 NP_309785.1 CDS ECs1758 NC_002695.1 1758657 1758905 R similar to excisionase [Bacteriophage 21] gi|139674|sp|P27079|VXIS_BPP21; excisionase complement(1758657..1758905) Escherichia coli O157:H7 str. Sakai 913093 NP_309786.1 CDS ECs1759 NC_002695.1 1758970 1761441 R similar to hypothetical protein ydfE [Escherichia coli cryptic prophage/truncated insertion sequence IS2 fusion] gi|78597|pir||S03698; exonuclease complement(1758970..1761441) Escherichia coli O157:H7 str. Sakai 913091 NP_309787.1 CDS ECs1760 NC_002695.1 1761534 1761725 R similar to hypothetical protein YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein complement(1761534..1761725) Escherichia coli O157:H7 str. Sakai 913090 NP_309788.1 CDS ECs1761 NC_002695.1 1761722 1761910 R similar to cell division inhibitor dicB [Escherichia coli] gi|2507009|sp|P09557|DICB_ECOLI; cell division inhibition protein; DicB complement(1761722..1761910) Escherichia coli O157:H7 str. Sakai 913089 NP_309789.1 CDS ECs1762 NC_002695.1 1762384 1762617 D hypothetical protein 1762384..1762617 Escherichia coli O157:H7 str. Sakai 913087 NP_309790.1 CDS ECs1763 NC_002695.1 1762595 1763002 R hypothetical protein complement(1762595..1763002) Escherichia coli O157:H7 str. Sakai 913086 NP_309791.1 CDS ECs1764 NC_002695.1 1763025 1763243 R similar to hypothetical 8.3 KD protein YdfC [Escherichia coli] gi|140586|sp|P21418|YDFC_ECOLI; hypothetical protein complement(1763025..1763243) Escherichia coli O157:H7 str. Sakai 913085 NP_944527.1 CDS ECs5428 NC_002695.1 1763316 1763615 R hypothetical protein complement(1763316..1763615) Escherichia coli O157:H7 str. Sakai 2693743 NP_309792.1 CDS ECs1765 NC_002695.1 1763879 1764286 R The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA complement(1763879..1764286) Escherichia coli O157:H7 str. Sakai 913084 NP_309793.1 CDS ECs1766 NC_002695.1 1764363 1764590 D probable repressor protein of division inhibition gene dicB; similar to DicC [Escherichia coli] gi|118633|sp|P06965|DICC_ECOLI; DNA-binding transcriptional regulator DicC 1764363..1764590 Escherichia coli O157:H7 str. Sakai 913083 NP_309794.1 CDS ECs1767 NC_002695.1 1764574 1765125 D similar to hypothetical 11.0 kDa protein YdfX [Escherichia coli] gi|3183265|sp|P76165|YDFX_ECOLI; hypothetical protein 1764574..1765125 Escherichia coli O157:H7 str. Sakai 913082 NP_309795.1 CDS ECs1768 NC_002695.1 1765097 1766137 D similar to replication termination factor (prepriming protein I) DnaT [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein 1765097..1766137 Escherichia coli O157:H7 str. Sakai 913081 NP_309796.1 CDS ECs1769 NC_002695.1 1765926 1766591 D similar to phage replication proteins e.g. protein 14 [phage phi-80] gi|137937|sp|P14814|VG14_BPPH8; phage replication protein 1765926..1766591 Escherichia coli O157:H7 str. Sakai 913080 NP_309799.1 CDS ECs1772 NC_002695.1 1768219 1768977 D similar to accessory colonization factor AcfC [Vibrio cholerae] gi|558481|gb|AAA50604.1, Anm (attachment and effacement of negative mutant) protein [Escherichia coli] gi|6715555|gb|AAB48445.2; colonization factor 1768219..1768977 Escherichia coli O157:H7 str. Sakai 913076 NP_309800.1 CDS ECs1773 NC_002695.1 1769256 1769468 D probable toxic protein; similar to Hok/Gef family e.g. Gef [Escherichia coli] gi|2120017|pir||S40540; prophage maintenance protein 1769256..1769468 Escherichia coli O157:H7 str. Sakai 913074 NP_309801.1 CDS ECs1774 NC_002695.1 1769689 1769946 D similar to Rem protein [Escherichia coli] gi|132324|sp|P07010|REM_ECOLI; hypothetical protein 1769689..1769946 Escherichia coli O157:H7 str. Sakai 913072 NP_309802.1 CDS ECs1775 NC_002695.1 1770016 1770294 D similar to orf QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1; hypothetical protein 1770016..1770294 Escherichia coli O157:H7 str. Sakai 913071 NP_309803.1 CDS ECs1776 NC_002695.1 1770296 1771342 D similar to hypothetical protein b1560 [Escherichia coli] gi|7466196|pir||C64911, hypothetical protein A [phage P1] gi|732234|sp|Q06262|YORA_BPP1; hypothetical protein 1770296..1771342 Escherichia coli O157:H7 str. Sakai 913070 NP_309804.1 CDS ECs1777 NC_002695.1 1771355 1771714 D probable crossover junction endodeoxyribonuclease; similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1, crossover junction endodeoxyribonucleases e.g. Rus [Escherichia coli cryptic lambdoid prophage; endonuclease 1771355..1771714 Escherichia coli O157:H7 str. Sakai 913069 NP_309805.1 CDS ECs1778 NC_002695.1 1771723 1772253 D hypothetical protein 1771723..1772253 Escherichia coli O157:H7 str. Sakai 913068 NP_309806.1 CDS ECs1779 NC_002695.1 1772372 1772692 D similar to orf2 [Bacteriophage P27] gi|8346569|emb|CAB93762.1|; lipoprotein 1772372..1772692 Escherichia coli O157:H7 str. Sakai 913067 NP_309807.1 CDS ECs1780 NC_002695.1 1772843 1773901 D similar to orf3 [Bacteriophage P27] gi|8346570|emb|CAB93763.1, adenine specific modification methylases e.g. Gp52 [phage N15] gi|7433503|pir||T13139; DNA methylase 1772843..1773901 Escherichia coli O157:H7 str. Sakai 913066 NP_309808.1 CDS ECs1781 NC_002695.1 1774698 1776551 D similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 1774698..1776551 Escherichia coli O157:H7 str. Sakai 913049 NP_309809.1 CDS ECs1782 NC_002695.1 1776701 1776916 D similar to holin e.g. [Bacteriophage 933W] gi|4499808|emb|CAB39307.1; holin 1776701..1776916 Escherichia coli O157:H7 str. Sakai 913047 NP_309810.1 CDS ECs1783 NC_002695.1 1776921 1777265 D similar to hypothetical protein YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 1776921..1777265 Escherichia coli O157:H7 str. Sakai 913045 NP_309811.1 CDS ECs1784 NC_002695.1 1777316 1777849 D similar to endolysins e.g. [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin 1777316..1777849 Escherichia coli O157:H7 str. Sakai 913044 NP_309812.1 CDS ECs1785 NC_002695.1 1778120 1778689 D similar to antirepressor protein Ant [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520, antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1778120..1778689 Escherichia coli O157:H7 str. Sakai 913041 NP_309813.1 CDS ECs1786 NC_002695.1 1778843 1779310 D endopeptidase (host lysis); similar to Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1|, Rz endopeptidases e.g. [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 1778843..1779310 Escherichia coli O157:H7 str. Sakai 913037 NP_309815.1 CDS ECs1788 NC_002695.1 1779673 1779900 R similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein complement(1779673..1779900) Escherichia coli O157:H7 str. Sakai 913028 NP_309816.1 CDS ECs1789 NC_002695.1 1779942 1780307 D similar to DNAse [Bacteriophage phi-C31] gi|1107475|emb|CAA62587.1; Dnase 1779942..1780307 Escherichia coli O157:H7 str. Sakai 913025 NP_944528.1 CDS ECs5431 NC_002695.1 1779960 1780205 R hypothetical protein complement(1779960..1780205) Escherichia coli O157:H7 str. Sakai 2693744 NP_309818.1 CDS ECs1791 NC_002695.1 1780597 1781160 D similar to terminase small subunit [Bacillus subtilis PBSX phage] gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 1780597..1781160 Escherichia coli O157:H7 str. Sakai 912994 NP_309819.1 CDS ECs1792 NC_002695.1 1781157 1782818 D similar to phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 1781157..1782818 Escherichia coli O157:H7 str. Sakai 912990 NP_309820.1 CDS ECs1793 NC_002695.1 1782882 1784819 D similar to prohead proteases e.g. [Bacteriophage HK97] gi|1722780|sp|P49860|VP4_BPHK7; major head protein/prohead protease 1782882..1784819 Escherichia coli O157:H7 str. Sakai 912961 NP_309822.1 CDS ECs1795 NC_002695.1 1785031 1787610 D similar to head portal proteins, e.g. [Bacteriophage HK022] gi|6863114|gb|AAF30355.1|AF069308_3; portal protein 1785031..1787610 Escherichia coli O157:H7 str. Sakai 912946 NP_309823.1 CDS ECs1796 NC_002695.1 1787613 1787939 D hypothetical protein 1787613..1787939 Escherichia coli O157:H7 str. Sakai 912943 NP_309824.1 CDS ECs1797 NC_002695.1 1787949 1788299 D similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 1787949..1788299 Escherichia coli O157:H7 str. Sakai 912938 NP_309825.1 CDS ECs1798 NC_002695.1 1788296 1788742 D similar to phage hypothetical proteins e.g. Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 1788296..1788742 Escherichia coli O157:H7 str. Sakai 912937 NP_309826.1 CDS ECs1799 NC_002695.1 1788739 1789083 D similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 1788739..1789083 Escherichia coli O157:H7 str. Sakai 912932 NP_309827.1 CDS ECs1800 NC_002695.1 1789013 1789858 D similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail subunit 1789013..1789858 Escherichia coli O157:H7 str. Sakai 912931 NP_309828.1 CDS ECs1801 NC_002695.1 1789864 1790238 D similar to tail assembly chaperone Gp14 [Bacteriophage HK97] gi|6901600|gb|AAF31103.1; tail assembly chaperone 1789864..1790238 Escherichia coli O157:H7 str. Sakai 912930 NP_309829.1 CDS ECs1802 NC_002695.1 1790262 1790543 D produced by translational frameshift; similar to C-terminal part of Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1|; hypothetical protein 1790262..1790543 Escherichia coli O157:H7 str. Sakai 912927 NP_309830.1 CDS ECs1803 NC_002695.1 1790596 1793676 D similar to tail length tape measure proteins e.g. [Bacteriophage HK97] gi|6901589|gb|AAF31092.1|AF069529_5; tail length tape measure protein 1790596..1793676 Escherichia coli O157:H7 str. Sakai 912925 NP_309831.1 CDS ECs1804 NC_002695.1 1793669 1794010 D similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1793669..1794010 Escherichia coli O157:H7 str. Sakai 912922 NP_309832.1 CDS ECs1805 NC_002695.1 1794010 1794447 D similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1794010..1794447 Escherichia coli O157:H7 str. Sakai 912921 NP_309833.1 CDS ECs1806 NC_002695.1 1794635 1798111 D similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1794635..1798111 Escherichia coli O157:H7 str. Sakai 912919 NP_309834.1 CDS ECs1807 NC_002695.1 1798179 1798778 D similar to outer membrane protein Lom precursors e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2, [Bacteriophage lambda] gi|138693|sp|P03701|VLOM_LAMBD; outer membrane protein 1798179..1798778 Escherichia coli O157:H7 str. Sakai 912918 NP_309835.1 CDS ECs1808 NC_002695.1 1798930 1800243 D similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 1798930..1800243 Escherichia coli O157:H7 str. Sakai 912917 NP_309836.1 CDS ECs1809 NC_002695.1 1800245 1800514 D similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 1800245..1800514 Escherichia coli O157:H7 str. Sakai 912916 NP_309839.1 CDS ECs1812 NC_002695.1 1801541 1802866 R hypothetical protein complement(1801541..1802866) Escherichia coli O157:H7 str. Sakai 912909 NP_309840.1 CDS ECs1813 NC_002695.1 1803527 1804219 R similar to integrases e.g. [Bacteriophage HK022] gi|138560|sp|P16407|VINT_BPHK0; integrase complement(1803527..1804219) Escherichia coli O157:H7 str. Sakai 912908 NP_309841.1 CDS ECs1814 NC_002695.1 1804693 1805604 D hypothetical protein 1804693..1805604 Escherichia coli O157:H7 str. Sakai 912906 NP_309842.1 CDS ECs1815 NC_002695.1 1805670 1806239 D hypothetical protein 1805670..1806239 Escherichia coli O157:H7 str. Sakai 912903 NP_309845.1 CDS ECs1818 NC_002695.1 1807205 1808743 R similar to L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein complement(1807205..1808743) Escherichia coli O157:H7 str. Sakai 912900 NP_309846.1 CDS ECs1819 NC_002695.1 1808793 1809140 R similar to L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1|; hypothetical protein complement(1808793..1809140) Escherichia coli O157:H7 str. Sakai 912899 NP_309847.1 CDS ECs1820 NC_002695.1 1809137 1809517 R similar to L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1|; hypothetical protein complement(1809137..1809517) Escherichia coli O157:H7 str. Sakai 912896 NP_309848.1 CDS ECs1821 NC_002695.1 1809857 1810135 R hypothetical protein complement(1809857..1810135) Escherichia coli O157:H7 str. Sakai 912892 NP_309851.1 CDS ECs1824 NC_002695.1 1810846 1811493 R similar to hypothetical proteins e.g. orf2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein complement(1810846..1811493) Escherichia coli O157:H7 str. Sakai 912888 NP_309852.1 CDS ECs1825 NC_002695.1 1811677 1812267 D similar to TrcA (bfpT-regulated chaperone-like protein) -like proteins e.g. TrcA [Escherichia coli strain B171-8] gi|4126789|dbj|BAA36747.1; bfpT-regulated chaperone-like protein 1811677..1812267 Escherichia coli O157:H7 str. Sakai 912883 NP_309856.1 CDS ECs1829 NC_002695.1 1815738 1816244 R similar to YCIE_ECOLI gi|1787511 (conserved in Escherichia coli K-12); hypothetical protein complement(1815738..1816244) Escherichia coli O157:H7 str. Sakai 912873 NP_309857.1 CDS ECs1830 NC_002695.1 1816290 1816790 R similar to YCIF_ECOLI gi|1787512 (conserved in Escherichia coli K-12); hypothetical protein complement(1816290..1816790) Escherichia coli O157:H7 str. Sakai 912869 NP_309858.2 CDS ECs1831 NC_002695.1 1816876 1817055 R similar to YCIG_ECOLI gi|1787513 (conserved in Escherichia coli K-12); hypothetical protein complement(1816876..1817055) Escherichia coli O157:H7 str. Sakai 912863 NP_309859.1 CDS trpA NC_002695.1 1817436 1818242 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1817436..1818242) Escherichia coli O157:H7 str. Sakai 912862 NP_309860.1 CDS ECs1833 NC_002695.1 1818242 1819435 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1818242..1819435) Escherichia coli O157:H7 str. Sakai 912860 NP_309861.1 CDS ECs1834 NC_002695.1 1819447 1820808 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1819447..1820808) Escherichia coli O157:H7 str. Sakai 912854 NP_309862.1 CDS ECs1835 NC_002695.1 1820809 1822404 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1820809..1822404) Escherichia coli O157:H7 str. Sakai 912851 NP_309863.1 CDS ECs1836 NC_002695.1 1822404 1823966 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1822404..1823966) Escherichia coli O157:H7 str. Sakai 912849 NP_309865.1 CDS ECs1838 NC_002695.1 1824240 1825121 D similar to YCIV_ECOLI gi|1787520 (conserved in Escherichia coli K-12); hypothetical protein 1824240..1825121 Escherichia coli O157:H7 str. Sakai 912844 NP_309866.3 CDS ECs1839 NC_002695.1 1825082 1825738 D similar to YCIO_ECOLI gi|1787521 (conserved in Escherichia coli K-12); hypothetical protein 1825082..1825738 Escherichia coli O157:H7 str. Sakai 912843 NP_309867.1 CDS ECs1840 NC_002695.1 1825766 1827349 D similar to YCIQ_ECOLI gi|1787522, YCIQ_ECOLI gi|1787522; hypothetical protein 1825766..1827349 Escherichia coli O157:H7 str. Sakai 912840 NP_309868.1 CDS ECs1841 NC_002695.1 1827562 1828434 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1827562..1828434 Escherichia coli O157:H7 str. Sakai 912836 NP_309869.1 CDS ECs1842 NC_002695.1 1828474 1829064 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1828474..1829064) Escherichia coli O157:H7 str. Sakai 912833 NP_309870.1 CDS ECs1843 NC_002695.1 1829061 1829819 R similar to YCIK_ECOLI gi|1787526 (conserved in Escherichia coli K-12); short chain dehydrogenase complement(1829061..1829819) Escherichia coli O157:H7 str. Sakai 912829 NP_309871.1 CDS ECs1844 NC_002695.1 1830039 1831088 D SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1830039..1831088 Escherichia coli O157:H7 str. Sakai 912827 NP_309872.1 CDS ECs1845 NC_002695.1 1831124 1831375 R similar to YCIN_ECOLI gi|1787528 (conserved in Escherichia coli K-12); hypothetical protein complement(1831124..1831375) Escherichia coli O157:H7 str. Sakai 912821 NP_309873.1 CDS ECs1846 NC_002695.1 1831755 1834352 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1831755..1834352 Escherichia coli O157:H7 str. Sakai 912819 NP_309874.1 CDS cysB NC_002695.1 1834562 1835536 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1834562..1835536 Escherichia coli O157:H7 str. Sakai 912818 NP_309876.1 CDS ECs1849 NC_002695.1 1836538 1839213 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1836538..1839213 Escherichia coli O157:H7 str. Sakai 912815 NP_309877.1 CDS ribA NC_002695.1 1839277 1839867 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1839277..1839867) Escherichia coli O157:H7 str. Sakai 912813 NP_309878.1 CDS ECs1851 NC_002695.1 1840037 1840801 D similar to PGPB_ECOLI gi|1787534 (conserved in Escherichia coli K-12); phosphatidylglycerophosphatase B 1840037..1840801 Escherichia coli O157:H7 str. Sakai 912812 NP_309879.1 CDS ECs1852 NC_002695.1 1840950 1841258 D similar to YCIS_ECOLI gi|1787535 (conserved in Escherichia coli K-12); hypothetical protein 1840950..1841258 Escherichia coli O157:H7 str. Sakai 912811 NP_309880.1 CDS ECs1853 NC_002695.1 1841265 1842434 D similar to YCIM_ECOLI gi|2367116 (conserved in Escherichia coli K-12); tetratricopeptide repeat protein 1841265..1842434 Escherichia coli O157:H7 str. Sakai 912810 NP_309881.1 CDS ECs1854 NC_002695.1 1842627 1843364 D OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1842627..1843364 Escherichia coli O157:H7 str. Sakai 912806 NP_309882.1 CDS ECs1855 NC_002695.1 1843361 1843690 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1843361..1843690 Escherichia coli O157:H7 str. Sakai 912805 NP_309883.1 CDS ECs1856 NC_002695.1 1843816 1844034 R similar to OSMB_ECOLI gi|1787539 (conserved in Escherichia coli K-12); lipoprotein complement(1843816..1844034) Escherichia coli O157:H7 str. Sakai 912802 NP_309884.1 CDS ECs1857 NC_002695.1 1844303 1845052 R similar to B1284_ECOLI gi|1787540 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator complement(1844303..1845052) Escherichia coli O157:H7 str. Sakai 912796 NP_944529.1 CDS ECs5432 NC_002695.1 1845142 1845315 R hypothetical protein complement(1845142..1845315) Escherichia coli O157:H7 str. Sakai 2693803 NP_309885.1 CDS ECs1858 NC_002695.1 1845463 1847448 R c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator complement(1845463..1847448) Escherichia coli O157:H7 str. Sakai 912794 NP_309886.1 CDS ECs1859 NC_002695.1 1847683 1849617 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1847683..1849617) Escherichia coli O157:H7 str. Sakai 912791 NP_309887.2 CDS ECs1860 NC_002695.1 1849685 1850812 R similar to YCIW_ECOLI gi|1787544 (conserved in Escherichia coli K-12); oxidoreductase complement(1849685..1850812) Escherichia coli O157:H7 str. Sakai 912788 NP_309888.1 CDS ECs1861 NC_002695.1 1850956 1851744 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase complement(1850956..1851744) Escherichia coli O157:H7 str. Sakai 912787 NP_309889.1 CDS ECs1862 NC_002695.1 1852222 1852788 D similar to transcription regulatory proteins e.g. UidR [Escherichia coli] gi|2495429|sp|Q59431|UIDR_ECOLI; transcription regulatory protein 1852222..1852788 Escherichia coli O157:H7 str. Sakai 912785 NP_309890.1 CDS ECs1863 NC_002695.1 1852937 1854058 D similar to multidrug-efflux transport protein precursors e.g. AcrA [Escherichia coli K-12] gi|399000|sp|P31223|ACRA_ECOLI; multidrug-efflux transport protein 1852937..1854058 Escherichia coli O157:H7 str. Sakai 912781 NP_309891.1 CDS ECs1864 NC_002695.1 1854058 1857141 D similar to multidrug-efflux transport proteins e.g. AcrB [Escherichia coli K-12] gi|399001|sp|P31224|ACRB_ECOLI; multidrug-efflux transport protein 1854058..1857141 Escherichia coli O157:H7 str. Sakai 912777 NP_309892.1 CDS ECs1865 NC_002695.1 1857164 1858537 D similar to outer membrane channel proteins e.g. OprM [Pseudomonas aeruginosa] gi|3184190|dbj|BAA28694.1; outer membrane channel protein 1857164..1858537 Escherichia coli O157:H7 str. Sakai 912775 NP_309893.1 CDS ECs1866 NC_002695.1 1858546 1859709 D similar to membrane transport proteins e.g. [Streptomyces coelicolor A3(2)] gi|6469269|emb|CAB61730.1; membrane transport protein 1858546..1859709 Escherichia coli O157:H7 str. Sakai 912751 NP_309894.1 CDS ECs1867 NC_002695.1 1859761 1860567 R similar to SAPF_ECOLI gi|1787547 (conserved in Escherichia coli K-12); peptide ABC transporter ATP-binding protein complement(1859761..1860567) Escherichia coli O157:H7 str. Sakai 912744 NP_309895.1 CDS ECs1868 NC_002695.1 1860569 1861561 R similar to SAPD_ECOLI gi|1787548 (conserved in Escherichia coli K-12); peptide ABC transporter ATP-binding protein complement(1860569..1861561) Escherichia coli O157:H7 str. Sakai 912736 NP_309896.1 CDS ECs1869 NC_002695.1 1861561 1862451 R similar to SAPC_ECOLI gi|1787549 (conserved in Escherichia coli K-12); peptide transport permease complement(1861561..1862451) Escherichia coli O157:H7 str. Sakai 912734 NP_309897.1 CDS ECs1870 NC_002695.1 1862438 1863403 R similar to SAPB_ECOLI gi|1787550 (conserved in Escherichia coli K-12); peptide transport permease complement(1862438..1863403) Escherichia coli O157:H7 str. Sakai 912731 NP_309898.1 CDS ECs1871 NC_002695.1 1863400 1865043 R periplasmic protein; similar to SAPA_ECOLI gi|1787551 (conserved in Escherichia coli K-12); peptide transport-like protein complement(1863400..1865043) Escherichia coli O157:H7 str. Sakai 912723 NP_309899.1 CDS ECs1872 NC_002695.1 1865356 1865601 R similar to YMJA_ECOLI gi|1787552 (conserved in Escherichia coli K-12); hypothetical protein complement(1865356..1865601) Escherichia coli O157:H7 str. Sakai 912721 NP_309900.2 CDS ECs1873 NC_002695.1 1865735 1867120 R similar to YCJJ_ECOLI gi|1787553 (conserved in Escherichia coli K-12); amino acid/amine transport protein complement(1865735..1867120) Escherichia coli O157:H7 str. Sakai 912717 NP_309901.2 CDS ECs1874 NC_002695.1 1867423 1868841 R similar to B1297_ECOLI gi|1787555 (conserved in Escherichia coli K-12); glutamine synthetase complement(1867423..1868841) Escherichia coli O157:H7 str. Sakai 912703 NP_309902.2 CDS puuD NC_002695.1 1869053 1869817 D catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1869053..1869817 Escherichia coli O157:H7 str. Sakai 912701 NP_309903.1 CDS ECs1876 NC_002695.1 1869844 1870401 D regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1869844..1870401 Escherichia coli O157:H7 str. Sakai 912699 NP_309904.1 CDS ECs1877 NC_002695.1 1870551 1872038 D catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1870551..1872038 Escherichia coli O157:H7 str. Sakai 912694 NP_309905.1 CDS ECs1878 NC_002695.1 1872040 1873320 D similar to ORDL_ECOLI gi|1787559 (conserved in Escherichia coli K-12); oxidoreductase 1872040..1873320 Escherichia coli O157:H7 str. Sakai 912689 NP_309906.1 CDS ECs1879 NC_002695.1 1873358 1874623 D putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1873358..1874623 Escherichia coli O157:H7 str. Sakai 912688 NP_309907.2 CDS pspF NC_002695.1 1874754 1875731 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1874754..1875731) Escherichia coli O157:H7 str. Sakai 912687 NP_309908.1 CDS ECs1881 NC_002695.1 1875898 1876566 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1875898..1876566 Escherichia coli O157:H7 str. Sakai 912684 NP_309909.1 CDS pspB NC_002695.1 1876620 1876844 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1876620..1876844 Escherichia coli O157:H7 str. Sakai 912683 NP_309910.1 CDS ECs1883 NC_002695.1 1876844 1877203 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; PspC family transcriptional regulator 1876844..1877203 Escherichia coli O157:H7 str. Sakai 912672 NP_309911.1 CDS ECs1884 NC_002695.1 1877212 1877433 D similar to PSPD_ECOLI gi|1787565 (conserved in Escherichia coli K-12); peripheral inner membrane phage-shock protein 1877212..1877433 Escherichia coli O157:H7 str. Sakai 912668 NP_309912.1 CDS ECs1885 NC_002695.1 1877508 1877822 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1877508..1877822 Escherichia coli O157:H7 str. Sakai 912667 NP_309917.1 CDS ECs1890 NC_002695.1 1881037 1881918 D similar to YCJO_ECOLI gi|1787570 (conserved in Escherichia coli K-12); binding-protein dependent transport protein 1881037..1881918 Escherichia coli O157:H7 str. Sakai 912626 NP_309918.1 CDS ECs1891 NC_002695.1 1881905 1882747 D similar to YCJP_ECOLI gi|1787571 (conserved in Escherichia coli K-12); transport system permease 1881905..1882747 Escherichia coli O157:H7 str. Sakai 912625 NP_309919.1 CDS ECs1892 NC_002695.1 1882778 1883830 D similar to YCJQ_ECOLI gi|1787572 (conserved in Escherichia coli K-12); oxidoreductase 1882778..1883830 Escherichia coli O157:H7 str. Sakai 912623 NP_309920.1 CDS ECs1893 NC_002695.1 1883848 1884636 D similar to B1314_ECOLI gi|1787573 (conserved in Escherichia coli K-12); hypothetical protein 1883848..1884636 Escherichia coli O157:H7 str. Sakai 912614 NP_309921.1 CDS ECs1894 NC_002695.1 1884646 1885701 D similar to YCJS_ECOLI gi|1787574 (conserved in Escherichia coli K-12); dehydrogenase 1884646..1885701 Escherichia coli O157:H7 str. Sakai 912546 NP_309922.1 CDS ECs1895 NC_002695.1 1885698 1887965 D similar to YCJT_ECOLI gi|1787575 (conserved in Escherichia coli K-12); hypothetical protein 1885698..1887965 Escherichia coli O157:H7 str. Sakai 912526 NP_309923.1 CDS ECs1896 NC_002695.1 1887962 1888621 D similar to YCJU_ECOLI gi|1787576 (conserved in Escherichia coli K-12); beta-phosphoglucomutase 1887962..1888621 Escherichia coli O157:H7 str. Sakai 912522 NP_309924.1 CDS ECs1897 NC_002695.1 1888635 1889717 D similar to ABC transporter ATP-binding protein YCJV_ECOLI gi|1787577 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 1888635..1889717 Escherichia coli O157:H7 str. Sakai 912514 NP_309925.1 CDS ECs1898 NC_002695.1 1889762 1890667 D similar to OMPG_ECOLI gi|1787579 (conserved in Escherichia coli K-12); outer membrane protein 1889762..1890667 Escherichia coli O157:H7 str. Sakai 912504 NP_309926.1 CDS ECs1899 NC_002695.1 1890778 1891776 R similar to YCJW_ECOLI gi|1787580 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator complement(1890778..1891776) Escherichia coli O157:H7 str. Sakai 912493 NP_309927.1 CDS ECs1900 NC_002695.1 1891931 1893328 D similar to YCJX_ECOLI gi|1787581 (conserved in Escherichia coli K-12); hypothetical protein 1891931..1893328 Escherichia coli O157:H7 str. Sakai 912488 NP_309928.1 CDS ECs1901 NC_002695.1 1893325 1894386 D similar to YCJF_ECOLI gi|1787582 (conserved in Escherichia coli K-12); hypothetical protein 1893325..1894386 Escherichia coli O157:H7 str. Sakai 912484 NP_309929.1 CDS ECs1902 NC_002695.1 1894534 1896075 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1894534..1896075 Escherichia coli O157:H7 str. Sakai 912481 NP_309930.1 CDS tpx NC_002695.1 1896119 1896625 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1896119..1896625) Escherichia coli O157:H7 str. Sakai 912478 NP_309931.2 CDS ECs1904 NC_002695.1 1896744 1897709 D similar to YCJG_ECOLI gi|1787585 (conserved in Escherichia coli K-12); muconate cycloisomerase I 1896744..1897709 Escherichia coli O157:H7 str. Sakai 912460 NP_309932.1 CDS ECs1905 NC_002695.1 1897684 1898472 R similar to YCJI_ECOLI gi|1787586 (conserved in Escherichia coli K-12); murein peptide amidase A complement(1897684..1898472) Escherichia coli O157:H7 str. Sakai 912455 NP_309933.2 CDS ECs1906 NC_002695.1 1898703 1899353 R similar to hypothetical protein [Xylella fastidiosa] gi|9106817|gb|AAF84556.1|AE003997_12; hypothetical protein complement(1898703..1899353) Escherichia coli O157:H7 str. Sakai 912442 NP_309936.1 CDS ECs1909 NC_002695.1 1900292 1901224 R similar to B1327_ECOLI gi|1787587 (conserved in Escherichia coli K-12); hypothetical protein complement(1900292..1901224) Escherichia coli O157:H7 str. Sakai 912427 NP_309937.1 CDS ECs1910 NC_002695.1 1901350 1902249 D similar to YCJZ_ECOLI gi|1787589 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 1901350..1902249 Escherichia coli O157:H7 str. Sakai 912423 NP_309938.2 CDS ECs1911 NC_002695.1 1902585 1904198 D similar to B1329_ECOLI gi|1787590 (conserved in Escherichia coli K-12); transport periplasmic protein 1902585..1904198 Escherichia coli O157:H7 str. Sakai 912407 NP_309939.1 CDS ECs1912 NC_002695.1 1904249 1905280 R similar to B1330_ECOLI gi|1787591 (conserved in Escherichia coli K-12); hypothetical protein complement(1904249..1905280) Escherichia coli O157:H7 str. Sakai 912403 NP_309940.1 CDS ECs1913 NC_002695.1 1905524 1905781 D similar to YNAJ_ECOLI gi|1787593 (conserved in Escherichia coli K-12); hypothetical protein 1905524..1905781 Escherichia coli O157:H7 str. Sakai 912396 NP_309941.1 CDS ECs1914 NC_002695.1 1905831 1906781 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1905831..1906781) Escherichia coli O157:H7 str. Sakai 912394 NP_309942.1 CDS ECs1915 NC_002695.1 1906933 1907685 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1906933..1907685) Escherichia coli O157:H7 str. Sakai 912392 NP_309943.1 CDS ECs1916 NC_002695.1 1907880 1908395 R similar to OGT_ECOLI gi|1787596 (conserved in Escherichia coli K-12); O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1907880..1908395) Escherichia coli O157:H7 str. Sakai 912389 NP_309944.1 CDS ECs1917 NC_002695.1 1908406 1909020 R similar to C-terminal part (307-510 in 510 aa) of pump protein YDAH_ECOLI gi|1787597; hypothetical protein complement(1908406..1909020) Escherichia coli O157:H7 str. Sakai 912380 NP_309945.1 CDS ECs1918 NC_002695.1 1909209 1910099 R OrfB; transposase of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase complement(1909209..1910099) Escherichia coli O157:H7 str. Sakai 912376 NP_309946.1 CDS ECs1919 NC_002695.1 1910096 1910422 R OrfA; transposase of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase complement(1910096..1910422) Escherichia coli O157:H7 str. Sakai 912364 NP_309947.1 CDS ECs1920 NC_002695.1 1910448 1911245 R similar to YDAH_ECOLI gi|1787597; may be truncated; pump protein complement(1910448..1911245) Escherichia coli O157:H7 str. Sakai 912359 NP_309948.1 CDS ECs1921 NC_002695.1 1911282 1912727 R similar to B1337_ECOLI gi|1787598 (conserved in Escherichia coli K-12); hypothetical protein complement(1911282..1912727) Escherichia coli O157:H7 str. Sakai 912350 NP_309949.2 CDS ECs1922 NC_002695.1 1912727 1914037 R similar to YDAJ_ECOLI gi|1787599 (conserved in Escherichia coli K-12); aminohydrolase complement(1912727..1914037) Escherichia coli O157:H7 str. Sakai 912338 NP_309950.1 CDS ECs1923 NC_002695.1 1914213 1915121 D similar to YDAK_ECOLI gi|1787601 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 1914213..1915121 Escherichia coli O157:H7 str. Sakai 912331 NP_309951.1 CDS ECs1924 NC_002695.1 1915451 1916014 D similar to YDAL_ECOLI gi|1787602 (conserved in Escherichia coli K-12); hypothetical protein 1915451..1916014 Escherichia coli O157:H7 str. Sakai 912328 NP_309952.1 CDS ECs1925 NC_002695.1 1916035 1917327 R similar to B1341_ECOLI gi|1787603 (conserved in Escherichia coli K-12); hypothetical protein complement(1916035..1917327) Escherichia coli O157:H7 str. Sakai 912323 NP_309953.1 CDS zntB NC_002695.1 1917522 1918505 D similar to B1342_ECOLI gi|1787604 (conserved in Escherichia coli K-12); zinc transporter 1917522..1918505 Escherichia coli O157:H7 str. Sakai 912321 NP_309954.1 CDS ECs1927 NC_002695.1 1918983 1920356 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1918983..1920356 Escherichia coli O157:H7 str. Sakai 912313 NP_309955.1 CDS ECs1928 NC_002695.1 1920485 1921420 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1920485..1921420) Escherichia coli O157:H7 str. Sakai 912308 NP_309956.1 CDS ECs1929 NC_002695.1 1921472 1922707 R similar to B1345_ECOLI gi|1787607 (conserved in Escherichia coli K-12); transposase complement(1921472..1922707) Escherichia coli O157:H7 str. Sakai 912302 NP_309957.2 CDS ECs1930 NC_002695.1 1922709 1922924 R similar to YDAQ_ECOLI gi|1787608 (conserved in Escherichia coli K-12); hypothetical protein complement(1922709..1922924) Escherichia coli O157:H7 str. Sakai 912301 NP_309958.1 CDS ECs1931 NC_002695.1 1923024 1923212 R Rac prophage; hypothetical protein complement(1923024..1923212) Escherichia coli O157:H7 str. Sakai 912300 NP_309959.1 CDS lar NC_002695.1 1923250 1923399 R seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage; restriction alleviation and modification protein complement(1923250..1923399) Escherichia coli O157:H7 str. Sakai 912297 NP_309960.1 CDS recT NC_002695.1 1923455 1924264 R similar to RECT_ECOLI gi|1787611 (conserved in Escherichia coli K-12); recombination and repair protein RecT complement(1923455..1924264) Escherichia coli O157:H7 str. Sakai 912294 NP_309961.1 CDS ECs1934 NC_002695.1 1924257 1926857 R The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC.; exonuclease VIII complement(1924257..1926857) Escherichia coli O157:H7 str. Sakai 912288 NP_309962.1 CDS ECs1935 NC_002695.1 1926959 1927234 R Rac prophage hypothetical protein; hypothetical protein complement(1926959..1927234) Escherichia coli O157:H7 str. Sakai 917139 NP_944530.1 CDS ECs5433 NC_002695.1 1927309 1927485 R hypothetical protein complement(1927309..1927485) Escherichia coli O157:H7 str. Sakai 2693825 NP_309963.1 CDS kil NC_002695.1 1927479 1927712 R Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein complement(1927479..1927712) Escherichia coli O157:H7 str. Sakai 917140 NP_309964.2 CDS ECs1937 NC_002695.1 1928142 1928630 D similar to SIEB_ECOLI gi|1787616 (conserved in Escherichia coli K-12); phage superinfection exclusion protein 1928142..1928630 Escherichia coli O157:H7 str. Sakai 917383 NP_309965.1 CDS ECs1939 NC_002695.1 1928627 1928782 R similar to YDAF_ECOLI in sieB-racR intergenic region gi|3915965|sp|P38395 (not identified but conserved in K-12); hypothetical protein complement(1928627..1928782) Escherichia coli O157:H7 str. Sakai 917660 NP_309967.1 CDS ECs1940 NC_002695.1 1928793 1928972 R similar to B1355_ECOLI gi|1787618 (conserved in Escherichia coli K-12); hypothetical protein complement(1928793..1928972) Escherichia coli O157:H7 str. Sakai 917587 NP_309968.1 CDS ECs1941 NC_002695.1 1929215 1929526 R similar to regulatory proteins e.g. regulatory protein CI (235 aa) [Bacteriophage HK022] gi|1350835|sp|P18680; transcriptional regulator complement(1929215..1929526) Escherichia coli O157:H7 str. Sakai 917511 NP_309969.1 CDS ECs1942 NC_002695.1 1929714 1929968 D similar to Cro [Bacteriophage HK022] gi|1350553|sp|P18679; regulatory protein 1929714..1929968 Escherichia coli O157:H7 str. Sakai 917782 NP_309970.1 CDS ECs1943 NC_002695.1 1929965 1930387 D similar to YDAT_ECOLI gi|1787621 (conserved in Escherichia coli K-12); hypothetical protein 1929965..1930387 Escherichia coli O157:H7 str. Sakai 917141 NP_309971.1 CDS ECs1944 NC_002695.1 1930465 1931253 D similar to YDAU_ECOLI gi|1787622; hypothetical protein 1930465..1931253 Escherichia coli O157:H7 str. Sakai 917723 NP_309972.1 CDS ECs1945 NC_002695.1 1931260 1932006 D acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 1931260..1932006 Escherichia coli O157:H7 str. Sakai 917146 NP_309973.1 CDS ECs1946 NC_002695.1 1931978 1932790 D similar to YDAW_ECOLI gi|1787624; hypothetical protein 1931978..1932790 Escherichia coli O157:H7 str. Sakai 917244 NP_309975.1 CDS ECs1948 NC_002695.1 1932806 1933228 D hypothetical protein 1932806..1933228 Escherichia coli O157:H7 str. Sakai 917148 NP_309976.1 CDS ECs1949 NC_002695.1 1933334 1933546 D hypothetical protein 1933334..1933546 Escherichia coli O157:H7 str. Sakai 917163 NP_309977.1 CDS ECs1950 NC_002695.1 1933798 1934061 D hypothetical protein 1933798..1934061 Escherichia coli O157:H7 str. Sakai 917143 NP_309978.1 CDS ECs1951 NC_002695.1 1934072 1934233 D similar to EaA protein [Bacteriophage P22] gi|418207|sp|Q03544|VEAA_BPP22; hypothetical protein 1934072..1934233 Escherichia coli O157:H7 str. Sakai 917144 NP_309979.1 CDS ECs1952 NC_002695.1 1934312 1934557 D similar to hypothetical protein [Bacteriophage H19J] gi|4490348|emb|CAB38711.1, Gp45 [Bacteriophage N15] gi|7521552|pir||T13131; hypothetical protein 1934312..1934557 Escherichia coli O157:H7 str. Sakai 917147 NP_309980.1 CDS ECs1953 NC_002695.1 1934989 1936140 D similar to methyltransferases e.g. cytosine-specific methyltransferase XorII [Xanthomonas oryzae pv.] gi|1709171|sp|P52311|MTX2_XANOR; methyltransferase 1934989..1936140 Escherichia coli O157:H7 str. Sakai 917152 NP_309981.1 CDS ECs1954 NC_002695.1 1936108 1937097 R similar to hypothetical protein HI0983 [Haemophilus influenzae] gi|1074592|pir||D64163; hypothetical protein complement(1936108..1937097) Escherichia coli O157:H7 str. Sakai 917149 NP_309982.1 CDS ECs1955 NC_002695.1 1937097 1938488 R hypothetical protein complement(1937097..1938488) Escherichia coli O157:H7 str. Sakai 917150 NP_309983.1 CDS ECs1956 NC_002695.1 1938988 1939587 D similar to Orf79 [Bacteriophage D3] gi|8895177|gb|AAF80835.1; hypothetical protein 1938988..1939587 Escherichia coli O157:H7 str. Sakai 917151 NP_309984.1 CDS ECs1957 NC_002695.1 1939587 1939877 D similar to hypothetical proteins e.g. YbcO [Escherichia coli cryptic prophage DLP12] gi|7467043|pir||C64787, Gp66 [Bacteriophage HK97] gi|6901638|gb|AAF31141.1; hypothetical protein 1939587..1939877 Escherichia coli O157:H7 str. Sakai 917153 NP_309985.1 CDS ECs1958 NC_002695.1 1939874 1940428 D similar to antiterminator protein Q [Bacteriophage 21] gi|4539484|emb|CAB39993.1; antitermination protein 1939874..1940428 Escherichia coli O157:H7 str. Sakai 917154 NP_309986.1 CDS ECs1959 NC_002695.1 1940990 1941421 D similar to probable TerB proteins e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein 1940990..1941421 Escherichia coli O157:H7 str. Sakai 917159 NP_309987.1 CDS ECs1960 NC_002695.1 1941418 1941585 D hypothetical protein 1941418..1941585 Escherichia coli O157:H7 str. Sakai 917158 NP_309988.1 CDS ECs1961 NC_002695.1 1941996 1943849 D similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 1941996..1943849 Escherichia coli O157:H7 str. Sakai 917160 NP_309989.1 CDS ECs1962 NC_002695.1 1943999 1944214 D host cell lysis; similar to holins e.g. [Bacteriophage 933W] gi|4499808|emb|CAB39307.1; holin 1943999..1944214 Escherichia coli O157:H7 str. Sakai 917161 NP_309990.1 CDS ECs1963 NC_002695.1 1944219 1944563 D similar to hypothetical protein [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 1944219..1944563 Escherichia coli O157:H7 str. Sakai 917164 NP_309991.1 CDS ECs1964 NC_002695.1 1944614 1945147 D host cell lysis; similar to endolysins e.g. [Bacteriophage 933W] gi|4335686|gb|AAD17382.1; endolysin 1944614..1945147 Escherichia coli O157:H7 str. Sakai 917162 NP_309992.1 CDS ECs1965 NC_002695.1 1945418 1945987 D similar to antirepressor [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P0; antirepressor protein 1945418..1945987 Escherichia coli O157:H7 str. Sakai 917172 NP_309993.1 CDS ECs1966 NC_002695.1 1946141 1946608 D host cell lysis; similar to endopeptidases e.g. [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1; endopeptidase 1946141..1946608 Escherichia coli O157:H7 str. Sakai 917168 NP_309994.1 CDS ECs1967 NC_002695.1 1946971 1947198 R similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1, hypothetical protein [Salmonella dublin] gi|3511132|gb|AAC33722.1; hypothetical protein complement(1946971..1947198) Escherichia coli O157:H7 str. Sakai 917167 NP_309995.1 CDS ECs1968 NC_002695.1 1947240 1947605 D similar to TerF-related protein [Deinococcus radiodurans] gi|7473956|pir||C75599, gp30 (DNase) [Bacteriophage phi-C31] gi|1107475|emb|CAA62587.1; DNase 1947240..1947605 Escherichia coli O157:H7 str. Sakai 917166 NP_944531.1 CDS ECs5437 NC_002695.1 1947258 1947503 R hypothetical protein complement(1947258..1947503) Escherichia coli O157:H7 str. Sakai 2693804 NP_309997.1 CDS ECs1970 NC_002695.1 1947895 1948458 D similar to phage terminase small subunits e.g. [Bacillus subtilis PBSX] gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 1947895..1948458 Escherichia coli O157:H7 str. Sakai 917180 NP_309998.1 CDS ECs1971 NC_002695.1 1948455 1950116 D similar to phage hypothetical proteins, e.g. phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 1948455..1950116 Escherichia coli O157:H7 str. Sakai 917171 NP_309999.1 CDS ECs1972 NC_002695.1 1950180 1952117 D similar to major head proteins e.g. [Mycobacterium phage L5] gi|465114|sp|Q05223|VG17_BPML5; phage major head protein/prohead protease 1950180..1952117 Escherichia coli O157:H7 str. Sakai 917173 NP_944532.1 CDS ECs5438 NC_002695.1 1952162 1952383 D hypothetical protein 1952162..1952383 Escherichia coli O157:H7 str. Sakai 2693805 NP_310001.1 CDS ECs1974 NC_002695.1 1952329 1953693 D similar to phage portal proteins e.g. [Bacteriophage D3] gi|5059250|gb|AAD38955.1; portal protein 1952329..1953693 Escherichia coli O157:H7 str. Sakai 917170 NP_310002.1 CDS ECs1975 NC_002695.1 1953690 1954913 D hypothetical protein 1953690..1954913 Escherichia coli O157:H7 str. Sakai 917175 NP_310003.1 CDS ECs1976 NC_002695.1 1954910 1955236 D hypothetical protein 1954910..1955236 Escherichia coli O157:H7 str. Sakai 917174 NP_310004.1 CDS ECs1977 NC_002695.1 1955246 1955596 D similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 1955246..1955596 Escherichia coli O157:H7 str. Sakai 917176 NP_310005.1 CDS ECs1978 NC_002695.1 1955593 1956039 D similar to phage hypothetical proteins e.g. Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 1955593..1956039 Escherichia coli O157:H7 str. Sakai 917177 NP_310006.1 CDS ECs1979 NC_002695.1 1956036 1956380 D similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 1956036..1956380 Escherichia coli O157:H7 str. Sakai 917182 NP_310007.1 CDS ECs1980 NC_002695.1 1956449 1957165 D similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail protein 1956449..1957165 Escherichia coli O157:H7 str. Sakai 917178 NP_310008.1 CDS ECs1981 NC_002695.1 1957171 1957545 D similar to tail assembly chaperon Gp14 [Bacteriophage HKJ97] gi|6901600|gb|AAF31103.1; tail assembly chaperon 1957171..1957545 Escherichia coli O157:H7 str. Sakai 917187 NP_310009.1 CDS ECs1982 NC_002695.1 1957569 1957850 D similar to Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1; may be produced by translational frameshift; hypothetical protein 1957569..1957850 Escherichia coli O157:H7 str. Sakai 917179 NP_310010.1 CDS ECs1983 NC_002695.1 1957902 1960982 D similar to tail length tape measure proteins e.g. [Bacteriophage HK97] gi|6901589|gb|AAF31092.1|AF069529_5; tail length tape measure protein 1957902..1960982 Escherichia coli O157:H7 str. Sakai 917181 NP_310011.1 CDS ECs1984 NC_002695.1 1960975 1961316 D similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1960975..1961316 Escherichia coli O157:H7 str. Sakai 917183 NP_310012.1 CDS ECs1985 NC_002695.1 1961316 1962014 D similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1961316..1962014 Escherichia coli O157:H7 str. Sakai 917185 NP_310013.1 CDS ECs1986 NC_002695.1 1962025 1962768 D similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|6901605|gb|AAF31108.1; tail assembly protein 1962025..1962768 Escherichia coli O157:H7 str. Sakai 917188 NP_310014.1 CDS ECs1987 NC_002695.1 1962666 1963346 D similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1962666..1963346 Escherichia coli O157:H7 str. Sakai 917184 NP_310015.1 CDS ECs1988 NC_002695.1 1963300 1963506 D hypothetical protein 1963300..1963506 Escherichia coli O157:H7 str. Sakai 917186 NP_310016.1 CDS ECs1989 NC_002695.1 1963537 1964064 R similar to copper/zinc-superoxide dismutases e.g. [Salmonella typhimurium] gi|2462699|emb|CAA73588.1; copper/zinc-superoxide dismutase complement(1963537..1964064) Escherichia coli O157:H7 str. Sakai 917190 NP_310017.1 CDS ECs1990 NC_002695.1 1964198 1967695 D similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1964198..1967695 Escherichia coli O157:H7 str. Sakai 917191 NP_310018.1 CDS ECs1991 NC_002695.1 1967766 1968365 D similar to outer membrane proteins e.g. Lom protein [Bacteriophage P-EibA] dad|AF151091-2|AAF63231.1; outer membrane protein 1967766..1968365 Escherichia coli O157:H7 str. Sakai 917206 NP_310019.1 CDS ECs1992 NC_002695.1 1968658 1969743 D similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59 (AF125520); tail fiber protein 1968658..1969743 Escherichia coli O157:H7 str. Sakai 917189 NP_310020.1 CDS ECs1993 NC_002695.1 1969673 1970014 D similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 1969673..1970014 Escherichia coli O157:H7 str. Sakai 917192 NP_310021.1 CDS ECs1994 NC_002695.1 1970127 1970702 D similar to ORF4 [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1970127..1970702 Escherichia coli O157:H7 str. Sakai 917198 NP_310022.1 CDS ECs1995 NC_002695.1 1970775 1971404 D similar to ORF4 [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1970775..1971404 Escherichia coli O157:H7 str. Sakai 917193 NP_310023.1 CDS ECs1996 NC_002695.1 1971486 1972127 D similar to ORF4 [Escherichia coli B171-8] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1971486..1972127 Escherichia coli O157:H7 str. Sakai 917197 NP_310024.2 CDS ECs1997 NC_002695.1 1972708 1973142 R similar to YNAF_ECOLI gi|1787640 (conserved in Escherichia coli K-12); filament protein complement(1972708..1973142) Escherichia coli O157:H7 str. Sakai 917194 NP_310027.1 CDS ECs2000 NC_002695.1 1974762 1978286 R similar to YDBK_ECOLI gi|1787642 (conserved in Escherichia coli K-12); oxidoreductase complement(1974762..1978286) Escherichia coli O157:H7 str. Sakai 917200 NP_944533.1 CDS ECs5439 NC_002695.1 1978560 1978826 D hypothetical protein 1978560..1978826 Escherichia coli O157:H7 str. Sakai 2693806 NP_310028.1 CDS ECs2001 NC_002695.1 1978823 1979245 R heat shock protein; similar to HSLJ_ECOLI gi|1787644 (conserved in Escherichia coli K-12); heat-inducible protein complement(1978823..1979245) Escherichia coli O157:H7 str. Sakai 917201 NP_310029.1 CDS ECs2002 NC_002695.1 1979356 1980345 R Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase complement(1979356..1980345) Escherichia coli O157:H7 str. Sakai 917202 NP_310030.1 CDS ECs2003 NC_002695.1 1980553 1983192 D similar to YDBH_ECOLI gi|1787646 (conserved in Escherichia coli K-12); hypothetical protein 1980553..1983192 Escherichia coli O157:H7 str. Sakai 917207 NP_310031.1 CDS ECs2004 NC_002695.1 1983189 1983374 D similar to YNBE_ECOLI gi|1787647 (conserved in Escherichia coli K-12); hypothetical protein 1983189..1983374 Escherichia coli O157:H7 str. Sakai 917199 NP_310032.1 CDS ECs2005 NC_002695.1 1983379 1983705 D similar to YDBL_ECOLI gi|1787648; hypothetical protein 1983379..1983705 Escherichia coli O157:H7 str. Sakai 917205 NP_310033.1 CDS ECs2006 NC_002695.1 1984119 1987154 D similar to BigA protein [Salmonella typhi] dad|AF133185-1|AAD29677.1, YdbA.2 [Escherichia coli] gi|7465766|pir||C48399; BigA-like protein 1984119..1987154 Escherichia coli O157:H7 str. Sakai 917204 NP_310034.1 CDS ECs2007 NC_002695.1 1987410 1989833 D similar to BigB protein [Salmonella typhi] dad|AF133185-2|AAD29678.1, YdbA.2 [Escherichia coli] gi|7465766|pir||C48399; BigB-like protein 1987410..1989833 Escherichia coli O157:H7 str. Sakai 917203 NP_310035.1 CDS ECs2008 NC_002695.1 1990053 1990913 D similar to YDBC_ECOLI gi|1787674 (conserved in Escherichia coli K-12); oxidoreductase 1990053..1990913 Escherichia coli O157:H7 str. Sakai 917217 NP_310036.1 CDS ECs2009 NC_002695.1 1990971 1993283 D similar to YDBD_ECOLI gi|1787675 (conserved in Escherichia coli K-12); hypothetical protein 1990971..1993283 Escherichia coli O157:H7 str. Sakai 917209 NP_310037.2 CDS ECs2010 NC_002695.1 1993454 1994059 D similar to B1408_ECOLI gi|1787676 (conserved in Escherichia coli K-12); hypothetical protein 1993454..1994059 Escherichia coli O157:H7 str. Sakai 917208 NP_310038.1 CDS ECs2011 NC_002695.1 1994059 1994955 D similar to B1409_ECOLI gi|1787677 (conserved in Escherichia coli K-12); phosphatidate cytidylyltransferase 1994059..1994955 Escherichia coli O157:H7 str. Sakai 917213 NP_310039.1 CDS ECs2012 NC_002695.1 1994971 1996728 D similar to B1410_ECOLI gi|1787678 (conserved in Escherichia coli K-12); hypothetical protein 1994971..1996728 Escherichia coli O157:H7 str. Sakai 917210 NP_310040.1 CDS ECs2013 NC_002695.1 1996742 1998034 D similar to YNBD_ECOLI gi|1787679 (conserved in Escherichia coli K-12); hypothetical protein 1996742..1998034 Escherichia coli O157:H7 str. Sakai 917211 NP_310041.1 CDS acpD NC_002695.1 1998085 1998690 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1998085..1998690) Escherichia coli O157:H7 str. Sakai 917215 NP_310042.1 CDS ECs2015 NC_002695.1 1998948 2002793 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1998948..2002793 Escherichia coli O157:H7 str. Sakai 917214 NP_310043.1 CDS ECs2016 NC_002695.1 2002939 2003364 D hypothetical protein 2002939..2003364 Escherichia coli O157:H7 str. Sakai 917212 NP_310044.1 CDS ECs2017 NC_002695.1 2003369 2003707 D hypothetical protein 2003369..2003707 Escherichia coli O157:H7 str. Sakai 917218 NP_310045.1 CDS ECs2018 NC_002695.1 2003694 2004125 D hypothetical protein 2003694..2004125 Escherichia coli O157:H7 str. Sakai 917221 NP_310046.1 CDS ECs2019 NC_002695.1 2004250 2004627 D hypothetical protein 2004250..2004627 Escherichia coli O157:H7 str. Sakai 917227 NP_310047.1 CDS ECs2020 NC_002695.1 2004743 2005543 D similar to YDCF_ECOLI gi|1787683 (conserved in Escherichia coli K-12); hypothetical protein 2004743..2005543 Escherichia coli O157:H7 str. Sakai 917216 NP_310048.1 CDS ECs2021 NC_002695.1 2005740 2007179 D NAD-linked; aldehyde dehydrogenase 2005740..2007179 Escherichia coli O157:H7 str. Sakai 917220 NP_310049.1 CDS ECs2022 NC_002695.1 2007221 2008222 R similar to G3P3_ECOLI sp|P33898; glyceraldehyde 3-phosphate dehydrogenase C complement(2007221..2008222) Escherichia coli O157:H7 str. Sakai 917219 NP_310050.2 CDS ECs2023 NC_002695.1 2008411 2008941 D B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 2008411..2008941 Escherichia coli O157:H7 str. Sakai 917223 NP_310051.1 CDS ECs2024 NC_002695.1 2009186 2009359 D similar to YDCA_ECOLI gi|1787688 (conserved in Escherichia coli K-12); hypothetical protein 2009186..2009359 Escherichia coli O157:H7 str. Sakai 917225 NP_944534.1 CDS ECs5440 NC_002695.1 2009431 2009580 R small toxic polypeptide complement(2009431..2009580) Escherichia coli O157:H7 str. Sakai 2693807 NP_310052.1 CDS ECs2025 NC_002695.1 2009471 2009638 R similar to B1420_ECOLI gi|1787689 (conserved in Escherichia coli K-12); hypothetical protein complement(2009471..2009638) Escherichia coli O157:H7 str. Sakai 917222 NP_310053.1 CDS ECs2026 NC_002695.1 2009979 2011619 D similar to TRG_ECOLI gi|1787690 (conserved in Escherichia coli K-12); methyl-accepting chemotaxis protein III 2009979..2011619 Escherichia coli O157:H7 str. Sakai 917242 NP_310054.2 CDS ECs2027 NC_002695.1 2011657 2012580 R similar to B1422_ECOLI gi|1787691 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(2011657..2012580) Escherichia coli O157:H7 str. Sakai 917224 NP_310055.1 CDS ECs2028 NC_002695.1 2012797 2014140 D similar to B1423_ECOLI gi|1787692 (conserved in Escherichia coli K-12); hypothetical protein 2012797..2014140 Escherichia coli O157:H7 str. Sakai 917226 NP_310056.1 CDS mdoD NC_002695.1 2014365 2016020 D involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 2014365..2016020 Escherichia coli O157:H7 str. Sakai 917232 NP_310057.1 CDS ECs2030 NC_002695.1 2015941 2016144 R similar to B1425_ECOLI gi|1787694 (conserved in Escherichia coli K-12); hypothetical protein complement(2015941..2016144) Escherichia coli O157:H7 str. Sakai 917229 NP_310058.2 CDS ECs2031 NC_002695.1 2016160 2016384 D similar to YDCH_ECOLI gi|1787696 (conserved in Escherichia coli K-12); hypothetical protein 2016160..2016384 Escherichia coli O157:H7 str. Sakai 917228 NP_310059.1 CDS ECs2032 NC_002695.1 2016447 2016743 D similar to RIML_ECOLI gi|1787697; interrupted; ribosomal-protein-serine N-acetyltransferase 2016447..2016743 Escherichia coli O157:H7 str. Sakai 917236 NP_310060.1 CDS ECs2033 NC_002695.1 2016978 2017958 R similar to B1428_ECOLI gi|1787698 (conserved in Escherichia coli K-12); hypothetical protein complement(2016978..2017958) Escherichia coli O157:H7 str. Sakai 917230 NP_310061.1 CDS ECs2034 NC_002695.1 2018082 2019074 D similar to TEHA_ECOLI gi|1787699 (conserved in Escherichia coli K-12); potassium-tellurite ethidium and proflavin transporter 2018082..2019074 Escherichia coli O157:H7 str. Sakai 917233 NP_310062.1 CDS ECs2035 NC_002695.1 2019071 2019664 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 2019071..2019664 Escherichia coli O157:H7 str. Sakai 917250 NP_310063.1 CDS ECs2036 NC_002695.1 2019968 2020636 D similar to B1431_ECOLI gi|1787701 (conserved in Escherichia coli K-12); hypothetical protein 2019968..2020636 Escherichia coli O157:H7 str. Sakai 917234 NP_310064.2 CDS ECs2038 NC_002695.1 2020671 2021843 R similar to membrane transport protein B1433_ECOLI gi|1787703 (conserved in Escherichia coli K-12); hypothetical protein complement(2020671..2021843) Escherichia coli O157:H7 str. Sakai 917231 NP_310065.1 CDS ECs2037 NC_002695.1 2021935 2022471 D similar to YDCN_ECOLI gi|1787704 (conserved in Escherichia coli K-12); hypothetical protein 2021935..2022471 Escherichia coli O157:H7 str. Sakai 917235 NP_310066.1 CDS ECs2039 NC_002695.1 2022502 2024505 D similar to YDCP_ECOLI gi|1787705 (conserved in Escherichia coli K-12); collagenase 2022502..2024505 Escherichia coli O157:H7 str. Sakai 917237 NP_310067.1 CDS ECs2040 NC_002695.1 2024597 2024827 R similar to B1436_ECOLI gi|1787707 (conserved in Escherichia coli K-12); hypothetical protein complement(2024597..2024827) Escherichia coli O157:H7 str. Sakai 917238 NP_310068.1 CDS ECs2041 NC_002695.1 2025013 2025210 R similar to B1437_ECOLI gi|1787708 (conserved in Escherichia coli K-12); hypothetical protein complement(2025013..2025210) Escherichia coli O157:H7 str. Sakai 917239 NP_310069.1 CDS ECs2042 NC_002695.1 2025250 2025687 D similar to B1438_ECOLI gi|1787709 (conserved in Escherichia coli K-12); hypothetical protein 2025250..2025687 Escherichia coli O157:H7 str. Sakai 917241 NP_310070.1 CDS ECs2043 NC_002695.1 2025766 2027172 D similar to B1439_ECOLI gi|1787710 (conserved in Escherichia coli K-12); transcriptional regulator 2025766..2027172 Escherichia coli O157:H7 str. Sakai 917248 NP_310071.1 CDS ECs2044 NC_002695.1 2027417 2028562 D similar to B1440_ECOLI gi|1787711 (conserved in Escherichia coli K-12); transporter 2027417..2028562 Escherichia coli O157:H7 str. Sakai 917240 NP_310072.1 CDS ECs2045 NC_002695.1 2028580 2029593 D similar to B1441_ECOLI gi|1787712 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2028580..2029593 Escherichia coli O157:H7 str. Sakai 917245 NP_310073.1 CDS ECs2046 NC_002695.1 2029594 2030535 D similar to B1442_ECOLI gi|1787713 (conserved in Escherichia coli K-12); transport system permease 2029594..2030535 Escherichia coli O157:H7 str. Sakai 917243 NP_310074.1 CDS ECs2047 NC_002695.1 2030525 2031319 D similar to B1443_ECOLI gi|1787714 (conserved in Escherichia coli K-12); transport system permease 2030525..2031319 Escherichia coli O157:H7 str. Sakai 917247 NP_310075.1 CDS ECs2048 NC_002695.1 2031341 2032765 D catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 2031341..2032765 Escherichia coli O157:H7 str. Sakai 917246 NP_310076.1 CDS ECs2049 NC_002695.1 2033104 2033325 D similar to B1445_ECOLI gi|1787716 (conserved in Escherichia coli K-12); hypothetical protein 2033104..2033325 Escherichia coli O157:H7 str. Sakai 917254 NP_310077.1 CDS ECs2050 NC_002695.1 2033411 2033644 D similar to B1446_ECOLI gi|1787717 (conserved in Escherichia coli K-12); hypothetical protein 2033411..2033644 Escherichia coli O157:H7 str. Sakai 917249 NP_310078.1 CDS ECs2051 NC_002695.1 2033645 2034094 R similar to B1447_ECOLI gi|1787718 (conserved in Escherichia coli K-12); hypothetical protein complement(2033645..2034094) Escherichia coli O157:H7 str. Sakai 917256 NP_310079.1 CDS ECs2052 NC_002695.1 2034091 2034609 R similar to B1448_ECOLI gi|1787719 (conserved in Escherichia coli K-12); resistance protein complement(2034091..2034609) Escherichia coli O157:H7 str. Sakai 917279 NP_310080.2 CDS ECs2053 NC_002695.1 2034766 2035827 D similar to YNCB_ECOLI gi|1787721 (conserved in Escherichia coli K-12); oxidoreductase 2034766..2035827 Escherichia coli O157:H7 str. Sakai 917251 NP_310081.2 CDS ECs2054 NC_002695.1 2036025 2036690 D similar to B1450_ECOLI gi|1787722 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 2036025..2036690 Escherichia coli O157:H7 str. Sakai 917252 NP_310082.1 CDS ECs2055 NC_002695.1 2036726 2038828 R similar to B1451_ECOLI gi|1787723 (conserved in Escherichia coli K-12); outer membrane receptor for iron transport complement(2036726..2038828) Escherichia coli O157:H7 str. Sakai 917253 NP_310083.1 CDS ECs2056 NC_002695.1 2039070 2040131 D similar to B1452_ECOLI gi|1787724 (conserved in Escherichia coli K-12); receptor 2039070..2040131 Escherichia coli O157:H7 str. Sakai 917255 NP_310084.2 CDS ECs2057 NC_002695.1 2040246 2041745 R similar to ANSP_ECOLI gi|1787725 (conserved in Escherichia coli K-12); L-asparagine permease complement(2040246..2041745) Escherichia coli O157:H7 str. Sakai 917257 NP_310085.1 CDS ECs2058 NC_002695.1 2042012 2042629 D similar to B1454_ECOLI gi|1787726 (conserved in Escherichia coli K-12); transferase 2042012..2042629 Escherichia coli O157:H7 str. Sakai 917259 NP_310086.1 CDS ECs2059 NC_002695.1 2042705 2042917 D similar to B1455_ECOLI gi|1787727; hypothetical protein 2042705..2042917 Escherichia coli O157:H7 str. Sakai 917258 NP_310087.1 CDS ECs2060 NC_002695.1 2043738 2045846 D similar to Vgr proteins e.g. VgrE protein [Escherichia coli] gi|2920625|gb|AAC32465.1; protein VgrE 2043738..2045846 Escherichia coli O157:H7 str. Sakai 917261 NP_310088.1 CDS ECs2061 NC_002695.1 2045913 2050115 D core protein with extension; similar to Rhs core proteins e.g. RhsD [Escherichia coli] gi|1786706 (conserved in Escherichia coli K-12); protein RhsE 2045913..2050115 Escherichia coli O157:H7 str. Sakai 917262 NP_944535.1 CDS ECs5441 NC_002695.1 2050312 2050521 D hypothetical protein 2050312..2050521 Escherichia coli O157:H7 str. Sakai 2693808 NP_944536.1 CDS ECs5442 NC_002695.1 2051029 2051208 D hypothetical protein 2051029..2051208 Escherichia coli O157:H7 str. Sakai 2693809 NP_310091.1 CDS ECs2064 NC_002695.1 2052288 2052515 D 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 2052288..2052515 Escherichia coli O157:H7 str. Sakai 917264 NP_310092.1 CDS ECs2065 NC_002695.1 2052519 2052962 R similar to B1462_ECOLI gi|1787735 (conserved in Escherichia coli K-12); hypothetical protein complement(2052519..2052962) Escherichia coli O157:H7 str. Sakai 917265 NP_310093.1 CDS ECs2066 NC_002695.1 2053261 2053995 D similar to N-hydroxyarylamine O-acetyltransferase B1463_ECOLI gi|1787736; N-hydroxyarylamine O-acetyltransferase 2053261..2053995 Escherichia coli O157:H7 str. Sakai 917263 NP_310094.1 CDS ECs2067 NC_002695.1 2054201 2055094 R similar to YDDE_ECOLI gi|1787737 (conserved in Escherichia coli K-12); hypothetical protein complement(2054201..2055094) Escherichia coli O157:H7 str. Sakai 917267 NP_310095.1 CDS ECs2068 NC_002695.1 2055173 2055853 R similar to NARV_ECOLI gi|1787738 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit gamma complement(2055173..2055853) Escherichia coli O157:H7 str. Sakai 917268 NP_310096.1 CDS ECs2069 NC_002695.1 2055850 2056545 R similar to NARW_ECOLI gi|1787739 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit delta complement(2055850..2056545) Escherichia coli O157:H7 str. Sakai 917271 NP_310097.1 CDS ECs2070 NC_002695.1 2056545 2058089 R similar to NARY_ECOLI gi|1787740 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit beta complement(2056545..2058089) Escherichia coli O157:H7 str. Sakai 917269 NP_310098.1 CDS ECs2071 NC_002695.1 2058086 2061826 R similar to NARG_ECOLI gi|1787477 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit alpha complement(2058086..2061826) Escherichia coli O157:H7 str. Sakai 917270 NP_310099.1 CDS ECs2072 NC_002695.1 2061908 2063296 R similar to NARU_ECOLI gi|1787743 (conserved in Escherichia coli K-12); nitrite extrusion protein 2 complement(2061908..2063296) Escherichia coli O157:H7 str. Sakai 917273 NP_310100.1 CDS ECs2073 NC_002695.1 2063602 2064861 R similar to B1471_ECOLI gi|1787745, B1470_ECOLI gi|1787744; hypothetical protein complement(2063602..2064861) Escherichia coli O157:H7 str. Sakai 917274 NP_310101.1 CDS ECs2074 NC_002695.1 2064924 2065592 R similar to glycoprotein B1471_ECOLI gi|1787745; hypothetical protein complement(2064924..2065592) Escherichia coli O157:H7 str. Sakai 917272 NP_310102.1 CDS ECs2075 NC_002695.1 2065679 2066182 R similar to IpaH protein IPA7_SHIFL gi|124813|sp|P18014, YDDK_ECOLI gi|3183258|sp|P76123; IpaH-like protein complement(2065679..2066182) Escherichia coli O157:H7 str. Sakai 917281 NP_310103.1 CDS ECs2076 NC_002695.1 2066351 2067451 R similar to outer membrane porin precursors e.g. NMPC_ECOLI gi|1786765; outer membrane porin protein complement(2066351..2067451) Escherichia coli O157:H7 str. Sakai 917276 NP_310104.3 CDS ECs2077 NC_002695.1 2067710 2068591 R similar to YDDG_ECOLI gi|1787747 (conserved in Escherichia coli K-12); hypothetical protein complement(2067710..2068591) Escherichia coli O157:H7 str. Sakai 917278 NP_310105.1 CDS ECs2078 NC_002695.1 2068823 2071870 D similar to FDNG_ECOLI gi|3868719 (conserved in Escherichia coli K-12); nitrate-inducible formate dehydrogenase-N alpha subunit 2068823..2071870 Escherichia coli O157:H7 str. Sakai 917275 NP_310106.1 CDS ECs2079 NC_002695.1 2071883 2072767 D similar to FDOH_ECOLI gi|1790326 (conserved in Escherichia coli K-12); nitrate-inducible formate dehydrogenase-N iron-sulfur beta subunit 2071883..2072767 Escherichia coli O157:H7 str. Sakai 917277 NP_310107.1 CDS ECs2080 NC_002695.1 2072760 2073413 D nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 2072760..2073413 Escherichia coli O157:H7 str. Sakai 917301 NP_310108.2 CDS ECs2081 NC_002695.1 2073641 2073925 R similar to YDDM_ECOLI gi|1787751 (conserved in Escherichia coli K-12); hypothetical protein complement(2073641..2073925) Escherichia coli O157:H7 str. Sakai 917287 NP_310109.2 CDS ECs2082 NC_002695.1 2074071 2075081 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(2074071..2075081) Escherichia coli O157:H7 str. Sakai 917284 NP_310110.2 CDS ECs2083 NC_002695.1 2075215 2076912 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(2075215..2076912) Escherichia coli O157:H7 str. Sakai 917295 NP_310111.1 CDS rpsV NC_002695.1 2077069 2077206 R protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 complement(2077069..2077206) Escherichia coli O157:H7 str. Sakai 917282 NP_310112.2 CDS ECs2085 NC_002695.1 2077308 2077523 R similar to B1481_ECOLI gi|1787756 (conserved in Escherichia coli K-12); biofilm-dependent modulation protein complement(2077308..2077523) Escherichia coli O157:H7 str. Sakai 917280 NP_310113.1 CDS ECs2086 NC_002695.1 2077868 2078299 D similar to OSMC_ECOLI gi|1787757 (conserved in Escherichia coli K-12); osmotically inducible protein 2077868..2078299 Escherichia coli O157:H7 str. Sakai 917283 NP_310114.1 CDS ECs2087 NC_002695.1 2078355 2079281 R similar to B1483_ECOLI gi|1787758 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(2078355..2079281) Escherichia coli O157:H7 str. Sakai 917285 NP_310115.1 CDS ECs2088 NC_002695.1 2079274 2080260 R similar to B1484_ECOLI gi|1787759 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(2079274..2080260) Escherichia coli O157:H7 str. Sakai 917286 NP_310116.1 CDS ECs2089 NC_002695.1 2080257 2081153 R similar to B1485_ECOLI gi|1787760 (conserved in Escherichia coli K-12); ATP-dependent peptide transporter membrane subunit complement(2080257..2081153) Escherichia coli O157:H7 str. Sakai 917288 NP_310117.1 CDS ECs2090 NC_002695.1 2081150 2081896 R similar to transport system permease B1486_ECOLI gi|1787761; hypothetical protein complement(2081150..2081896) Escherichia coli O157:H7 str. Sakai 917289 NP_310118.1 CDS ECs2091 NC_002695.1 2082173 2083723 R similar to B1487_ECOLI gi|1787762 (conserved in Escherichia coli K-12); hemin-binding lipoprotein complement(2082173..2083723) Escherichia coli O157:H7 str. Sakai 917292 NP_310119.1 CDS ECs2092 NC_002695.1 2083737 2084318 R catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase complement(2083737..2084318) Escherichia coli O157:H7 str. Sakai 917290 NP_310122.1 CDS ECs2095 NC_002695.1 2086990 2088372 R similar to B1490_ECOLI gi|1787766 (conserved in Escherichia coli K-12); hypothetical protein complement(2086990..2088372) Escherichia coli O157:H7 str. Sakai 917293 NP_310123.1 CDS ECs2096 NC_002695.1 2088749 2090068 R similar to B1491_ECOLI gi|1787767 (conserved in Escherichia coli K-12); hypothetical protein complement(2088749..2090068) Escherichia coli O157:H7 str. Sakai 917296 NP_310124.1 CDS ECs2097 NC_002695.1 2090199 2091734 R similar to XASA_ECOLI gi|1787768 (conserved in Escherichia coli K-12); acid sensitivity protein complement(2090199..2091734) Escherichia coli O157:H7 str. Sakai 917297 NP_310125.1 CDS ECs2098 NC_002695.1 2091890 2093290 R similar to GADB_ECOLI gi|1787769 (conserved in Escherichia coli K-12); glutamate decarboxylase complement(2091890..2093290) Escherichia coli O157:H7 str. Sakai 917300 NP_310126.1 CDS ECs2099 NC_002695.1 2093651 2096446 R similar to PQQL_ECOLI gi|1787770 (conserved in Escherichia coli K-12); peptidase complement(2093651..2096446) Escherichia coli O157:H7 str. Sakai 917298 NP_310127.1 CDS ECs2100 NC_002695.1 2096491 2098863 R similar to YDDB_ECOLI gi|1787771 (conserved in Escherichia coli K-12); hypothetical protein complement(2096491..2098863) Escherichia coli O157:H7 str. Sakai 917306 NP_310128.1 CDS ECs2101 NC_002695.1 2098901 2100586 R similar to YDDA_ECOLI gi|1787772 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(2098901..2100586) Escherichia coli O157:H7 str. Sakai 917299 NP_310129.2 CDS ECs2102 NC_002695.1 2100877 2102034 R similar to B1497_ECOLI gi|1787774 (conserved in Escherichia coli K-12); hypothetical protein complement(2100877..2102034) Escherichia coli O157:H7 str. Sakai 917302 NP_310130.1 CDS ECs2103 NC_002695.1 2102086 2103801 R similar to B1498_ECOLI gi|1787775 (conserved in Escherichia coli K-12); sulfatase complement(2102086..2103801) Escherichia coli O157:H7 str. Sakai 917303 NP_310131.1 CDS ECs2104 NC_002695.1 2104172 2104933 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(2104172..2104933) Escherichia coli O157:H7 str. Sakai 917312 NP_310132.1 CDS ECs2105 NC_002695.1 2105007 2105204 R similar to B1500_ECOLI gi|1787777 (conserved in Escherichia coli K-12); hypothetical protein complement(2105007..2105204) Escherichia coli O157:H7 str. Sakai 917320 NP_310133.1 CDS ECs2106 NC_002695.1 2105452 2107731 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase complement(2105452..2107731) Escherichia coli O157:H7 str. Sakai 917305 NP_310134.1 CDS ECs2107 NC_002695.1 2108065 2108979 R similar to B1502_ECOLI gi|1787779 (conserved in Escherichia coli K-12); adhesin complement(2108065..2108979) Escherichia coli O157:H7 str. Sakai 917304 NP_310135.1 CDS ECs2108 NC_002695.1 2109039 2109542 R similar to B1503_ECOLI gi|1787780 (conserved in Escherichia coli K-12); fimbrial-like protein complement(2109039..2109542) Escherichia coli O157:H7 str. Sakai 917314 NP_310136.1 CDS ECs2109 NC_002695.1 2109555 2110085 R similar to B1504_ECOLI gi|1787781 (conserved in Escherichia coli K-12); fimbrial-like protein complement(2109555..2110085) Escherichia coli O157:H7 str. Sakai 917307 NP_310137.1 CDS ECs2110 NC_002695.1 2110099 2111247 R similar to B1505_ECOLI gi|1787782 (conserved in Escherichia coli K-12); outer membrane protein complement(2110099..2111247) Escherichia coli O157:H7 str. Sakai 917309 NP_310139.1 CDS ECs2112 NC_002695.1 2112792 2113502 R similar to fimbrial chaperone protein precursors e.g. FocC [Escherichia coli] gi|1169720|sp|P46008|FOCC_ECOLI; fimbrial chaperone protein complement(2112792..2113502) Escherichia coli O157:H7 str. Sakai 917313 NP_310140.1 CDS ECs2113 NC_002695.1 2113863 2114426 R similar to type 1 fimbrial protein precursors e.g. [Escherichia coli] gi|729528|sp|P04128|FM1A_ECOLI; type 1 fimbrial protein complement(2113863..2114426) Escherichia coli O157:H7 str. Sakai 917311 NP_310142.1 CDS ECs2115 NC_002695.1 2115400 2115960 R similar to DNA-binding regulator HIPA_ECOLI gi|1787785; hypothetical protein complement(2115400..2115960) Escherichia coli O157:H7 str. Sakai 917315 NP_310143.1 CDS ECs2116 NC_002695.1 2116580 2117980 R similar to B1509_ECOLI gi|1787787 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(2116580..2117980) Escherichia coli O157:H7 str. Sakai 917317 NP_310144.1 CDS ECs2117 NC_002695.1 2117977 2122008 R similar to YDEK_ECOLI gi|1787788 (conserved in Escherichia coli K-12); lipoprotein complement(2117977..2122008) Escherichia coli O157:H7 str. Sakai 917316 NP_310145.3 CDS ECs2118 NC_002695.1 2122539 2124131 R similar to YDEV_ECOLI gi|1787789 (conserved in Escherichia coli K-12); autoinducer-2 (AI-2) kinase complement(2122539..2124131) Escherichia coli O157:H7 str. Sakai 917318 NP_310146.1 CDS ECs2119 NC_002695.1 2124210 2125163 R similar to YDEW_ECOLI gi|1787791 (conserved in Escherichia coli K-12); SORC-type transcriptional regulator complement(2124210..2125163) Escherichia coli O157:H7 str. Sakai 917323 NP_310147.1 CDS ECs2120 NC_002695.1 2125412 2126947 D similar to B1513_ECOLI gi|1787792 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2125412..2126947 Escherichia coli O157:H7 str. Sakai 917319 NP_310148.1 CDS ECs2121 NC_002695.1 2126941 2127969 D similar to YDEY_ECOLI gi|1787793 (conserved in Escherichia coli K-12); transport system permease 2126941..2127969 Escherichia coli O157:H7 str. Sakai 917325 NP_310149.1 CDS ECs2122 NC_002695.1 2127969 2128961 D similar to YDEZ_ECOLI gi|1787794 (conserved in Escherichia coli K-12); transport system permease 2127969..2128961 Escherichia coli O157:H7 str. Sakai 917327 NP_310150.1 CDS ECs2123 NC_002695.1 2128973 2129995 D similar to B1516_ECOLI gi|1787795 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator 2128973..2129995 Escherichia coli O157:H7 str. Sakai 917324 NP_310151.1 CDS ECs2124 NC_002695.1 2130022 2130897 D similar to YNEB_ECOLI gi|1787796 (conserved in Escherichia coli K-12); aldolase 2130022..2130897 Escherichia coli O157:H7 str. Sakai 917321 NP_310152.1 CDS ECs2125 NC_002695.1 2130921 2131211 D similar to B1518_ECOLI gi|1787797 (conserved in Escherichia coli K-12); autoinducer-2 (AI-2) modifying protein LsrG 2130921..2131211 Escherichia coli O157:H7 str. Sakai 917322 NP_310153.1 CDS ECs2126 NC_002695.1 2131268 2132026 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 2131268..2132026 Escherichia coli O157:H7 str. Sakai 917326 NP_310154.1 CDS ECs2127 NC_002695.1 2132030 2132995 R similar to B1520_ECOLI gi|1787799 (conserved in Escherichia coli K-12); hypothetical protein complement(2132030..2132995) Escherichia coli O157:H7 str. Sakai 917350 NP_310155.1 CDS ECs2128 NC_002695.1 2133142 2134593 R catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase complement(2133142..2134593) Escherichia coli O157:H7 str. Sakai 917329 NP_310156.1 CDS ECs2129 NC_002695.1 2134820 2135767 R similar to B1522_ECOLI gi|1787802 (conserved in Escherichia coli K-12); hypothetical protein complement(2134820..2135767) Escherichia coli O157:H7 str. Sakai 917328 NP_310157.1 CDS ECs2130 NC_002695.1 2136377 2136736 R similar to B1523_ECOLI gi|1787803 (conserved in Escherichia coli K-12); hypothetical protein complement(2136377..2136736) Escherichia coli O157:H7 str. Sakai 917331 NP_310158.1 CDS ECs2131 NC_002695.1 2136736 2137662 R catalyzes the formation of glutamate from glutamine; glutaminase complement(2136736..2137662) Escherichia coli O157:H7 str. Sakai 917332 NP_310159.1 CDS ECs2132 NC_002695.1 2137726 2139138 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase complement(2137726..2139138) Escherichia coli O157:H7 str. Sakai 917330 NP_310160.1 CDS ECs2133 NC_002695.1 2139215 2140096 D similar to YNEJ_ECOLI gi|1787806 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 2139215..2140096 Escherichia coli O157:H7 str. Sakai 917333 NP_310161.1 CDS ECs2134 NC_002695.1 2140174 2140962 D similar to B1527_ECOLI gi|1787807; hypothetical protein 2140174..2140962 Escherichia coli O157:H7 str. Sakai 917337 NP_310162.1 CDS ECs2135 NC_002695.1 2141440 2142630 D similar to YDEA_ECOLI gi|1787808 (conserved in Escherichia coli K-12); sugar efflux transporter 2141440..2142630 Escherichia coli O157:H7 str. Sakai 917335 NP_310163.1 CDS ECs2136 NC_002695.1 2142655 2143320 R protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC complement(2142655..2143320) Escherichia coli O157:H7 str. Sakai 917334 NP_310164.2 CDS ECs2137 NC_002695.1 2143532 2143966 D Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; MarR family transcriptional regulator 2143532..2143966 Escherichia coli O157:H7 str. Sakai 917336 NP_310165.2 CDS ECs2138 NC_002695.1 2143986 2144369 D transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; MarA family transcriptional regulator 2143986..2144369 Escherichia coli O157:H7 str. Sakai 917339 NP_310166.1 CDS ECs2139 NC_002695.1 2144401 2144619 D similar to MARB_ECOLI gi|1787812 (conserved in Escherichia coli K-12); hypothetical protein 2144401..2144619 Escherichia coli O157:H7 str. Sakai 917340 NP_310167.1 CDS ECs2140 NC_002695.1 2144650 2145549 R similar to YDED_ECOLI gi|1787813 (conserved in Escherichia coli K-12); O-acetylserine/cysteine export protein complement(2144650..2145549) Escherichia coli O157:H7 str. Sakai 917338 NP_310168.1 CDS ECs2141 NC_002695.1 2145744 2146931 D YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 2145744..2146931 Escherichia coli O157:H7 str. Sakai 917342 NP_944538.1 CDS ECs5444 NC_002695.1 2146972 2147367 R hypothetical protein complement(2146972..2147367) Escherichia coli O157:H7 str. Sakai 2693811 NP_310169.1 CDS ECs2142 NC_002695.1 2147064 2147348 D hypothetical protein 2147064..2147348 Escherichia coli O157:H7 str. Sakai 917345 NP_310170.1 CDS ftrA NC_002695.1 2147459 2148433 D upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrA 2147459..2148433 Escherichia coli O157:H7 str. Sakai 917341 NP_310171.1 CDS ECs2144 NC_002695.1 2148855 2149745 R similar to YDEH_ECOLI gi|1787816 (conserved in Escherichia coli K-12); hypothetical protein complement(2148855..2149745) Escherichia coli O157:H7 str. Sakai 917344 NP_310172.1 CDS ECs2145 NC_002695.1 2150000 2150392 R similar to YDEI_ECOLI gi|1787817 (conserved in Escherichia coli K-12); hypothetical protein complement(2150000..2150392) Escherichia coli O157:H7 str. Sakai 917343 NP_310173.1 CDS ECs2146 NC_002695.1 2150668 2151186 D similar to YDEJ_ECOLI gi|1787818 (conserved in Escherichia coli K-12); competence damage-inducible protein A 2150668..2151186 Escherichia coli O157:H7 str. Sakai 917346 NP_310174.1 CDS ECs2147 NC_002695.1 2151231 2153276 R similar to DCP_ECOLI gi|1787819 (conserved in Escherichia coli K-12); dipeptidyl carboxypeptidase II complement(2151231..2153276) Escherichia coli O157:H7 str. Sakai 917348 NP_310175.1 CDS ECs2148 NC_002695.1 2153413 2154159 D NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 2153413..2154159 Escherichia coli O157:H7 str. Sakai 917355 NP_310176.1 CDS ECs2149 NC_002695.1 2154248 2154934 D similar to YDFH_ECOLI gi|1787821 (conserved in Escherichia coli K-12); hypothetical protein 2154248..2154934 Escherichia coli O157:H7 str. Sakai 917362 NP_310177.1 CDS ECs2150 NC_002695.1 2155111 2155314 D similar to B1541_ECOLI gi|1787822 (conserved in Escherichia coli K-12); hypothetical protein 2155111..2155314 Escherichia coli O157:H7 str. Sakai 917351 NP_310178.1 CDS ECs2151 NC_002695.1 2155350 2156810 R similar to YDFI_ECOLI gi|1787823 (conserved in Escherichia coli K-12); oxidoreductase complement(2155350..2156810) Escherichia coli O157:H7 str. Sakai 917357 NP_310179.1 CDS ECs2152 NC_002695.1 2156899 2158182 R similar to B1543_ECOLI gi|1787824 (conserved in Escherichia coli K-12); transporter complement(2156899..2158182) Escherichia coli O157:H7 str. Sakai 917349 NP_310180.1 CDS ECs2153 NC_002695.1 2158314 2158556 D similar to damage-inducible proteins e.g. DinI [Escherichia coli] gi|2498305|sp|Q47143|DINI_ECOLI; damage-inducible protein 2158314..2158556 Escherichia coli O157:H7 str. Sakai 917347 NP_310181.1 CDS ECs2154 NC_002695.1 2158718 2159359 R similar to hypothetical proteins e.g. ORF4 [Escherichia coli] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli] gi|4126790|dbj|BAA36748.1; hypothetical protein complement(2158718..2159359) Escherichia coli O157:H7 str. Sakai 917352 NP_310182.1 CDS ECs2155 NC_002695.1 2159441 2160070 R similar to hypothetical proteins e.g. ORF4 [Escherichia coli] gi|4126790|dbj|BAA36748.1, ORF2 [Escherichia coli] gi|4126792|dbj|BAA36750.1; hypothetical protein complement(2159441..2160070) Escherichia coli O157:H7 str. Sakai 917353 NP_310183.1 CDS ECs2156 NC_002695.1 2160143 2160718 R similar to hypothetical proteins e.g. ORF4 [Escherichia coli] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli] gi|4126790|dbj|BAA36748.1; hypothetical protein complement(2160143..2160718) Escherichia coli O157:H7 str. Sakai 917360 NP_310184.1 CDS ECs2157 NC_002695.1 2160832 2161101 R similar to hypothetical protein[Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein complement(2160832..2161101) Escherichia coli O157:H7 str. Sakai 917354 NP_310186.2 CDS ECs2159 NC_002695.1 2161515 2162324 R similar to tail fiber proteins e.g. Gp37 [Escherichia coli] gi|7466858|pir||G64887, orf-401 [Bacteriophage lambda] gi|140053|sp|P03764|Y401_LAMBD; tail fiber protein complement(2161515..2162324) Escherichia coli O157:H7 str. Sakai 917361 NP_310187.1 CDS ECs2160 NC_002695.1 2162389 2162988 R similar to Lom-like proteins e.g.[prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2, Lom [Bacteriophage lambda] gi|138693|sp|P03701|VLOM_LAMBD; outer host membrane protein complement(2162389..2162988) Escherichia coli O157:H7 str. Sakai 917374 NP_310188.1 CDS ECs2161 NC_002695.1 2163056 2166535 R host specificity protein; similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein complement(2163056..2166535) Escherichia coli O157:H7 str. Sakai 917358 NP_310189.1 CDS ECs2162 NC_002695.1 2166776 2167453 R similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein complement(2166776..2167453) Escherichia coli O157:H7 str. Sakai 917359 NP_310190.1 CDS ECs2163 NC_002695.1 2167351 2168034 R similar to tail assembly proteins e.g. GpK [Bacteriophage lambda gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein complement(2167351..2168034) Escherichia coli O157:H7 str. Sakai 917363 NP_944539.1 CDS ECs5445 NC_002695.1 2167863 2168093 R hypothetical protein complement(2167863..2168093) Escherichia coli O157:H7 str. Sakai 2693798 NP_310191.1 CDS ECs2164 NC_002695.1 2168104 2168802 R similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein complement(2168104..2168802) Escherichia coli O157:H7 str. Sakai 917364 NP_310192.1 CDS ECs2165 NC_002695.1 2168802 2169131 R similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein complement(2168802..2169131) Escherichia coli O157:H7 str. Sakai 917371 NP_310193.1 CDS ECs2166 NC_002695.1 2169128 2171740 R similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein complement(2169128..2171740) Escherichia coli O157:H7 str. Sakai 917365 NP_310194.1 CDS ECs2167 NC_002695.1 2171721 2172134 R similar to minor tail proteins e.g. GpG-T [Bacteriophage lambda] gi|7429179|pir||TLBPTL; may be produced by translational frameshift; minor tail protein complement(2171721..2172134) Escherichia coli O157:H7 str. Sakai 917366 NP_310195.1 CDS ECs2168 NC_002695.1 2172161 2172583 R similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein complement(2172161..2172583) Escherichia coli O157:H7 str. Sakai 917370 NP_310196.1 CDS ECs2169 NC_002695.1 2172597 2173349 R similar to protein V Bacteriophage lambda; hypothetical protein complement(2172597..2173349) Escherichia coli O157:H7 str. Sakai 917367 NP_310197.1 CDS ECs2170 NC_002695.1 2173357 2173752 R similar to minor tail proteins GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein complement(2173357..2173752) Escherichia coli O157:H7 str. Sakai 917369 NP_310198.1 CDS ECs2171 NC_002695.1 2173749 2174282 R similar to minor tail proteins e.g. GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein complement(2173749..2174282) Escherichia coli O157:H7 str. Sakai 917373 NP_310199.1 CDS ECs2172 NC_002695.1 2174297 2174650 R minor capsid protein; similar to minor capsid proteins e.g. GpFII [Bacteriophage lambda] gi|137575|sp|P03714|VCF2_LAMBD; tail attachment protein complement(2174297..2174650) Escherichia coli O157:H7 str. Sakai 917368 NP_310200.1 CDS ECs2173 NC_002695.1 2174662 2175060 R similar to DNA-packaging proteins e.g. GpFI [Bacteriophage lambda] gi|139324|sp|P03709|VPF1_LAMBD; DNA-packaging protein complement(2174662..2175060) Escherichia coli O157:H7 str. Sakai 917372 NP_310201.1 CDS ECs2174 NC_002695.1 2175102 2176127 R similar to major capsid proteins e.g. GpE [Bacteriophage lambda] gi|116701|sp|P05481|HEAD_BPPH8; major capsid protein complement(2175102..2176127) Escherichia coli O157:H7 str. Sakai 917378 NP_310202.1 CDS ECs2175 NC_002695.1 2176183 2176515 R major capsid protein; similar to major capsid proteins e.g. GpD [Bacteriophage lambda] gi|137566|sp|P03712|VCAD_LAMBD; head decoration protein complement(2176183..2176515) Escherichia coli O157:H7 str. Sakai 917375 NP_310203.1 CDS ECs2176 NC_002695.1 2176525 2177844 R similar to minor capsid protein precursors e.g. GpC [Bacteriophage lambda] gi|137565|sp|P03711|VCAC_LAMBD; contains capsid assembly protein Nu3-homolog; minor capsid protein complement(2176525..2177844) Escherichia coli O157:H7 str. Sakai 917382 NP_310204.1 CDS ECs2177 NC_002695.1 2177825 2179426 R minor capsid protein; similar to portal proteins e.g. GpB [Bacteriophage lambda] gi|138762|sp|P03710|VMCB_LAMBD; portal protein complement(2177825..2179426) Escherichia coli O157:H7 str. Sakai 917381 NP_310205.1 CDS ECs2178 NC_002695.1 2179423 2179629 R similar to head-to-tail joining proteins e.g. GpW [Bacteriophage lambda] gi|138415|sp|P03727|VHTJ_LAMBD; head-to-tail joining protein complement(2179423..2179629) Escherichia coli O157:H7 str. Sakai 917410 NP_310206.1 CDS ECs2179 NC_002695.1 2179626 2181551 R DNA-packaging protein; similar to terminase large subunits e.g. GpA [Bacteriophage lambda] gi|137616|sp|P03708|TERL_LAMBD; terminase large subunit complement(2179626..2181551) Escherichia coli O157:H7 str. Sakai 917377 NP_310207.1 CDS ECs2180 NC_002695.1 2181526 2182071 R similar to terminase small subunits e.g. Nu1 [Bacteriophage lambda]; terminase small subunit complement(2181526..2182071) Escherichia coli O157:H7 str. Sakai 917376 NP_310208.1 CDS ECs2181 NC_002695.1 2182458 2182682 D similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein 2182458..2182682 Escherichia coli O157:H7 str. Sakai 917379 NP_310209.1 CDS ECs2182 NC_002695.1 2182764 2183078 R similar to PerC (BfpW) transcriptional activator of eaeA/bfpA [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional regulator complement(2182764..2183078) Escherichia coli O157:H7 str. Sakai 917380 NP_310210.1 CDS ECs2184 NC_002695.1 2183542 2184000 R host cell lysis; similar to endopeptidases e.g. [Bacteriophage H-19B] gi|4335687|gb|AAD17383.1; endopeptidase complement(2183542..2184000) Escherichia coli O157:H7 str. Sakai 917385 NP_310212.1 CDS ECs2185 NC_002695.1 2184158 2184727 R similar to antirepressors e.g. [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46; antirepressor protein complement(2184158..2184727) Escherichia coli O157:H7 str. Sakai 917384 NP_310213.1 CDS ECs2186 NC_002695.1 2184998 2185531 R host cell lysis; similar to endolysins e.g. [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin complement(2184998..2185531) Escherichia coli O157:H7 str. Sakai 917387 NP_310214.1 CDS ECs2187 NC_002695.1 2185582 2185926 R similar to hypothetical protein gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein complement(2185582..2185926) Escherichia coli O157:H7 str. Sakai 917391 NP_310215.1 CDS ECs2188 NC_002695.1 2185931 2186137 R similar to holins e.g. [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1; holin complement(2185931..2186137) Escherichia coli O157:H7 str. Sakai 917389 NP_944540.1 CDS ECs5446 NC_002695.1 2186145 2186306 D hypothetical protein 2186145..2186306 Escherichia coli O157:H7 str. Sakai 2693799 NP_310216.1 CDS ECs2189 NC_002695.1 2186628 2188436 R similar to hypothetical proteins [Bacteriophage VT2-Sa] gi|5881634|dbj|BAA84325.1; hypothetical protein complement(2186628..2188436) Escherichia coli O157:H7 str. Sakai 917388 NP_310217.1 CDS ECs2190 NC_002695.1 2188914 2189345 R similar to tellurium resistance protein TerB proteins e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein complement(2188914..2189345) Escherichia coli O157:H7 str. Sakai 917393 NP_310218.1 CDS ECs2191 NC_002695.1 2189796 2190383 R similar to transcriptional regulators e.g. [Escherichia coli] gi|586679|sp|P37638|YHIW_ECOLI; transcriptional regulator complement(2189796..2190383) Escherichia coli O157:H7 str. Sakai 917394 NP_310219.1 CDS ECs2192 NC_002695.1 2190645 2190842 R similar to hypothetical protein [Bacteriophage P27] gi|8346569|emb|CAB93762.1; hypothetical protein complement(2190645..2190842) Escherichia coli O157:H7 str. Sakai 917395 NP_310220.1 CDS ECs2193 NC_002695.1 2191067 2191621 R similar to Q protein [Bacteriophage 21] gi|7440086|pir||D71566; anti-terminator protein complement(2191067..2191621) Escherichia coli O157:H7 str. Sakai 917398 NP_310221.1 CDS ECs2194 NC_002695.1 2191684 2191989 R similar crossover junction endodeoxyribonuclease [Escherichia coli] gi|2507117|sp|P40116|RUS_ECOLI, Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1; crossover junction endodeoxyribonuclease complement(2191684..2191989) Escherichia coli O157:H7 str. Sakai 917400 NP_310222.1 CDS ECs2195 NC_002695.1 2192002 2193084 R similar to B1560_ECOLI gi|1787843; hypothetical protein complement(2192002..2193084) Escherichia coli O157:H7 str. Sakai 917396 NP_310223.1 CDS ECs2196 NC_002695.1 2193053 2193325 R hypothetical protein complement(2193053..2193325) Escherichia coli O157:H7 str. Sakai 917399 NP_310224.1 CDS ECs2197 NC_002695.1 2193447 2193791 R similar to hypothetical protein [Bacteriophage 933W] gi|4585451|gb|AAD25479.1|AF125520_74, Ygi [Escherichia coli] gi|1723887|sp|P52083|YGIW_ECOLI; hypothetical protein complement(2193447..2193791) Escherichia coli O157:H7 str. Sakai 917401 NP_310225.1 CDS ECs2198 NC_002695.1 2193911 2194123 R prophage maintenance protein; similar to MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76, Hok/Gef family e.g. Gef [Escherichia coli] gi|2120017|pir||S40540; MokW protein complement(2193911..2194123) Escherichia coli O157:H7 str. Sakai 917402 NP_310226.1 CDS ECs2199 NC_002695.1 2194357 2194914 R similar to hypothetical protein [Bacteriophage 933W] gi|4585382|gb|AAD25410.1|AF125520_5; hypothetical protein complement(2194357..2194914) Escherichia coli O157:H7 str. Sakai 917406 NP_310227.1 CDS ECs2200 NC_002695.1 2194916 2195134 R similar to hypothetical protein [Bacteriophage 933W] gi|4585384|gb|AAD25412.1|AF125520_7; hypothetical protein complement(2194916..2195134) Escherichia coli O157:H7 str. Sakai 917403 NP_310228.1 CDS ECs2201 NC_002695.1 2195262 2195573 R hypothetical protein complement(2195262..2195573) Escherichia coli O157:H7 str. Sakai 917411 NP_310229.1 CDS ECs2202 NC_002695.1 2195566 2195793 R hypothetical protein complement(2195566..2195793) Escherichia coli O157:H7 str. Sakai 917404 NP_310230.1 CDS ECs2203 NC_002695.1 2195790 2196071 R similar to Gp9 [Bacteriophage Mu] gi|6010430|gb|AAF01133.1|AF083977_54; hypothetical protein complement(2195790..2196071) Escherichia coli O157:H7 str. Sakai 917407 NP_310231.1 CDS ECs2204 NC_002695.1 2196104 2196838 R similar to hypothetical protein YdaW [Escherichia coli] gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein complement(2196104..2196838) Escherichia coli O157:H7 str. Sakai 917405 NP_310232.1 CDS ECs2205 NC_002695.1 2196854 2197516 R similar to C-terminal half of replication protein 14 [Bacteriophage phi-80] gi|137937|sp|P14814|VG14_BPPH8; replication protein complement(2196854..2197516) Escherichia coli O157:H7 str. Sakai 917429 NP_310233.1 CDS ECs2206 NC_002695.1 2197308 2198351 R similar to DnaT [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein complement(2197308..2198351) Escherichia coli O157:H7 str. Sakai 917408 NP_310234.1 CDS ECs2207 NC_002695.1 2198420 2198845 R similar to hypothetical protein [Escherichia coli] gi|3025103|sp|P76064|YDAT_ECOLI; hypothetical protein complement(2198420..2198845) Escherichia coli O157:H7 str. Sakai 917409 NP_310235.1 CDS ECs2208 NC_002695.1 2198829 2199071 R similar to Cro [Bacteriophage P22] gi|132195|sp|P09964|RCRO_BPP22; regulatory protein complement(2198829..2199071) Escherichia coli O157:H7 str. Sakai 917412 NP_310236.1 CDS ECs2209 NC_002695.1 2199277 2199801 D similar to repressor proteins e.g. C2 [Bacteriophage P22] gi|133359|sp|P03035|RPC2_BPP22; repressor protein 2199277..2199801 Escherichia coli O157:H7 str. Sakai 917413 NP_310237.1 CDS ECs2210 NC_002695.1 2200013 2200246 D similar to hypothetical proteins e.g. YdfK [Escherichia coli] gi|140584|sp|P29008|YDFA_ECOLI, YdaF gi|3915965|sp|P38395|YDAF_ECOLIF; hypothetical protein 2200013..2200246 Escherichia coli O157:H7 str. Sakai 917415 NP_310238.1 CDS ECs2211 NC_002695.1 2200258 2200896 D similar to ATP-dependent protease La homolog gi|1708857|sp|P42425|LON2_BACSU; hypothetical protein 2200258..2200896 Escherichia coli O157:H7 str. Sakai 917417 NP_310239.1 CDS ECs2212 NC_002695.1 2200897 2201106 R hypothetical protein complement(2200897..2201106) Escherichia coli O157:H7 str. Sakai 917414 NP_310240.1 CDS ECs2213 NC_002695.1 2201155 2201415 R hypothetical protein complement(2201155..2201415) Escherichia coli O157:H7 str. Sakai 917416 NP_310241.1 CDS ECs2214 NC_002695.1 2201671 2201859 D similar to DicB [Escherichia coli] gi|226094|prf||1410309A; cell division inhibitor 2201671..2201859 Escherichia coli O157:H7 str. Sakai 917423 NP_310242.1 CDS ECs2215 NC_002695.1 2201856 2202044 D similar to hypothetical protein YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein 2201856..2202044 Escherichia coli O157:H7 str. Sakai 917421 NP_310243.1 CDS ECs2216 NC_002695.1 2202137 2203381 D similar to exonucleases e.g. exodeoxyribonuclease VIII [Escherichia coli] gi|2507105|sp|P15032|RECE_ECOLI; exonuclease 2202137..2203381 Escherichia coli O157:H7 str. Sakai 917419 NP_310244.1 CDS ECs2217 NC_002695.1 2203363 2203914 D similar to N-terminal part of integrases e.g. [Escherichia coli cryptic prophage] gi|7449509|pir||E64913; integrase 2203363..2203914 Escherichia coli O157:H7 str. Sakai 917420 NP_310245.1 CDS ECs2218 NC_002695.1 2204020 2204274 D hypothetical protein 2204020..2204274 Escherichia coli O157:H7 str. Sakai 917424 NP_310246.1 CDS ECs2219 NC_002695.1 2204277 2205167 R OrfB of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 IS629] gi|7443862|pir||T00240; transposase complement(2204277..2205167) Escherichia coli O157:H7 str. Sakai 917422 NP_310247.1 CDS ECs2220 NC_002695.1 2205164 2205490 R OrfA of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase complement(2205164..2205490) Escherichia coli O157:H7 str. Sakai 917426 NP_310248.1 CDS ECs2221 NC_002695.1 2205697 2206566 R similar to transposases e.g. [Yersinia pestis plasmid pMT1] gi|7447905|pir||T14710; transposase complement(2205697..2206566) Escherichia coli O157:H7 str. Sakai 917425 NP_310249.1 CDS ECs2222 NC_002695.1 2206610 2206990 D similar to L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1, hypothetical proteins e.g. Hp3 [Escherichia coli strain CFT073] gi|3661484|gb|AAC61715.1; hypothetical protein 2206610..2206990 Escherichia coli O157:H7 str. Sakai 917427 NP_310250.1 CDS ECs2223 NC_002695.1 2206987 2207334 D similar to L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1, hypothetical proteins e.g. Orf50 [Escherichia coli strain B171] gi|6009426|dbj|BAA84885.1; hypothetical protein 2206987..2207334 Escherichia coli O157:H7 str. Sakai 917428 NP_310251.1 CDS ECs2224 NC_002695.1 2207384 2208922 D similar to L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1, hypothetical protein [Escherichia coli plasmid pColV-K30] gi|3288156|emb|CAA11509.1; hypothetical protein 2207384..2208922 Escherichia coli O157:H7 str. Sakai 917432 NP_310253.1 CDS ECs2226 NC_002695.1 2209505 2209876 R similar to hypothetical proteins e.g. ORF2 in trcA region [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1, ORF4 in trcA region [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1; hypothetical protein complement(2209505..2209876) Escherichia coli O157:H7 str. Sakai 917435 NP_310254.1 CDS ECs2227 NC_002695.1 2210140 2210487 R similar to hypothetical protein [Lactococcus bacteriophage c2] gi|1146281|gb|AAA92162.1|; hypothetical protein complement(2210140..2210487) Escherichia coli O157:H7 str. Sakai 917431 NP_310256.1 CDS ECs2229 NC_002695.1 2210866 2211375 R similar to hypothetical proteins e.g. ORF4 in trcA region [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1, ORF2 in trcA region [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein complement(2210866..2211375) Escherichia coli O157:H7 str. Sakai 917433 NP_310257.1 CDS ECs2230 NC_002695.1 2211555 2211824 R similar to hypothetical protein [Bacteriophage 933W] gi|7649887|dbj|BAA94165.1; hypothetical protein complement(2211555..2211824) Escherichia coli O157:H7 str. Sakai 917437 NP_310258.1 CDS ECs2231 NC_002695.1 2211826 2213049 R similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein complement(2211826..2213049) Escherichia coli O157:H7 str. Sakai 917434 NP_310259.1 CDS ECs2232 NC_002695.1 2213114 2213713 R similar to Lom outer membrane proteins e.g. [Bacteriophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein complement(2213114..2213713) Escherichia coli O157:H7 str. Sakai 917449 NP_310263.1 CDS ECs2236 NC_002695.1 2217597 2218277 R similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein complement(2217597..2218277) Escherichia coli O157:H7 str. Sakai 917442 NP_310264.1 CDS ECs2237 NC_002695.1 2218175 2218849 R similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein complement(2218175..2218849) Escherichia coli O157:H7 str. Sakai 917441 NP_310265.1 CDS ECs2238 NC_002695.1 2218929 2219627 R similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein complement(2218929..2219627) Escherichia coli O157:H7 str. Sakai 917443 NP_310266.1 CDS ECs2239 NC_002695.1 2219627 2219968 R similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein complement(2219627..2219968) Escherichia coli O157:H7 str. Sakai 917444 NP_310267.1 CDS ECs2240 NC_002695.1 2219961 2223203 R similar to tail length tape measure proteins e.g. [Bacteriophage HK97] gi|6901589|gb|AAF31092.1|AF069529_5; tail length tape measure protein complement(2219961..2223203) Escherichia coli O157:H7 str. Sakai 917445 NP_310268.1 CDS ECs2241 NC_002695.1 2223251 2223532 R similar to Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1; may be produced by translational frameshift; tail protein complement(2223251..2223532) Escherichia coli O157:H7 str. Sakai 917450 NP_310269.1 CDS ECs2242 NC_002695.1 2223556 2223930 R similar to tail assembly chaperone [Bacteriophage HK97] gi|6901600|gb|AAF31103.1; tail assembly chaperone complement(2223556..2223930) Escherichia coli O157:H7 str. Sakai 917465 NP_310270.1 CDS ECs2243 NC_002695.1 2223945 2224661 R similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail subunit complement(2223945..2224661) Escherichia coli O157:H7 str. Sakai 917446 NP_310271.1 CDS ECs2244 NC_002695.1 2224727 2225071 R similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein complement(2224727..2225071) Escherichia coli O157:H7 str. Sakai 917448 NP_310272.1 CDS ECs2245 NC_002695.1 2225068 2225514 R similar to phage hypothetical proteins Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein complement(2225068..2225514) Escherichia coli O157:H7 str. Sakai 917447 NP_310273.1 CDS ECs2246 NC_002695.1 2225511 2225861 R similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor complement(2225511..2225861) Escherichia coli O157:H7 str. Sakai 917451 NP_310274.1 CDS ECs2247 NC_002695.1 2225871 2226197 R hypothetical protein complement(2225871..2226197) Escherichia coli O157:H7 str. Sakai 917452 NP_310275.1 CDS ECs2248 NC_002695.1 2226200 2228779 R similar to portal proteins e.g. [Bacteriophage D3] gi|5059250|gb|AAD38955.1; portal protein complement(2226200..2228779) Escherichia coli O157:H7 str. Sakai 917453 NP_944541.1 CDS ECs5451 NC_002695.1 2228725 2228946 R hypothetical protein complement(2228725..2228946) Escherichia coli O157:H7 str. Sakai 2693768 NP_310277.1 CDS ECs2250 NC_002695.1 2228991 2230928 R similar to prohead proteases e.g. [Rhodobacter capsulatus] gi|6467535|gb|AAF13181.1|AF181080_3; major head protein/prohead protease complement(2228991..2230928) Escherichia coli O157:H7 str. Sakai 917455 NP_310278.1 CDS ECs2251 NC_002695.1 2230992 2232653 R similar to hypothetical proteins e.g. phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit complement(2230992..2232653) Escherichia coli O157:H7 str. Sakai 917457 NP_310279.1 CDS ECs2252 NC_002695.1 2232650 2233213 R similar to terminase small subunit - PBSX phage Bacillus subtilis gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit complement(2232650..2233213) Escherichia coli O157:H7 str. Sakai 917470 NP_310280.1 CDS ECs2253 NC_002695.1 2233397 2233540 R hypothetical protein complement(2233397..2233540) Escherichia coli O157:H7 str. Sakai 917456 NP_310281.1 CDS ECs2254 NC_002695.1 2233503 2233868 R similar to DNase [Bacteriophage phi-C31] gi|1107475|emb|CAA62587.1; Dnase complement(2233503..2233868) Escherichia coli O157:H7 str. Sakai 917458 NP_310282.1 CDS ECs2255 NC_002695.1 2233910 2234137 D similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein 2233910..2234137 Escherichia coli O157:H7 str. Sakai 917459 NP_310283.1 CDS ECs2257 NC_002695.1 2234500 2234967 R cell lysis; similar to Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1, Rz endopeptidases e.g. [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase complement(2234500..2234967) Escherichia coli O157:H7 str. Sakai 917462 NP_310285.1 CDS ECs2258 NC_002695.1 2235121 2235690 R similar to Ant [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein complement(2235121..2235690) Escherichia coli O157:H7 str. Sakai 917461 NP_310286.1 CDS ECs2259 NC_002695.1 2235961 2236494 R similar to endolysins e.g. [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin complement(2235961..2236494) Escherichia coli O157:H7 str. Sakai 917467 NP_310287.1 CDS ECs2260 NC_002695.1 2236545 2236889 R similar to hypothetical protein YdfR (103 aa) [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein complement(2236545..2236889) Escherichia coli O157:H7 str. Sakai 917463 NP_310288.1 CDS ECs2261 NC_002695.1 2236894 2237100 R similar to holins e.g. [Bacteriophage H-19B] gi|2668771|gb|AAD04658.1; holin complement(2236894..2237100) Escherichia coli O157:H7 str. Sakai 917466 NP_944542.1 CDS ECs5452 NC_002695.1 2237108 2237254 D hypothetical protein 2237108..2237254 Escherichia coli O157:H7 str. Sakai 2693769 NP_310289.1 CDS ECs2262 NC_002695.1 2237549 2239399 R similar to hypothetical protein [Bacteriophage 933W]; hypothetical protein complement(2237549..2239399) Escherichia coli O157:H7 str. Sakai 917464 NP_310290.1 CDS ECs2263 NC_002695.1 2239448 2239576 R hypothetical protein complement(2239448..2239576) Escherichia coli O157:H7 str. Sakai 917469 NP_310291.1 CDS ECs2264 NC_002695.1 2239721 2239987 R hypothetical protein complement(2239721..2239987) Escherichia coli O157:H7 str. Sakai 917468 NP_310292.1 CDS ECs2265 NC_002695.1 2239878 2240306 R similar to tellurium resistance proteins (TerB) e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein complement(2239878..2240306) Escherichia coli O157:H7 str. Sakai 917479 NP_310294.1 CDS ECs2267 NC_002695.1 2240946 2241635 R similar to antitermination Q proteins e.g. [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; antitermination protein complement(2240946..2241635) Escherichia coli O157:H7 str. Sakai 917138 NP_310295.1 CDS ECs2268 NC_002695.1 2241632 2241991 R similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1, crossover junction endodeoxyribonucleases Rus; Holliday junction nuclease; crossover junction endodeoxyribonuclease complement(2241632..2241991) Escherichia coli O157:H7 str. Sakai 912470 NP_310296.1 CDS ECs2269 NC_002695.1 2242004 2243053 R similar to B1560_ECOLI gi|1787843; hypothetical protein complement(2242004..2243053) Escherichia coli O157:H7 str. Sakai 913934 NP_944589.1 CDS ECs5456 NC_002695.1 2243501 2243713 R hypothetical protein complement(2243501..2243713) Escherichia coli O157:H7 str. Sakai 2693770 NP_310297.1 CDS ECs2270 NC_002695.1 2243758 2243913 D hypothetical protein 2243758..2243913 Escherichia coli O157:H7 str. Sakai 912700 NP_310298.1 CDS ECs2271 NC_002695.1 2243902 2244006 R hypothetical protein complement(2243902..2244006) Escherichia coli O157:H7 str. Sakai 913195 NP_310299.1 CDS ECs2272 NC_002695.1 2244122 2244706 R hypothetical protein complement(2244122..2244706) Escherichia coli O157:H7 str. Sakai 912559 NP_310300.1 CDS ECs2273 NC_002695.1 2244763 2245158 R similar to hypothetical protein [Salmonella typhimurium] gi|7467246|pir||T03012, Ren proteins e.g. [Bacteriophage H-19] gi|2668762|gb|AAD04649.1; hypothetical protein complement(2244763..2245158) Escherichia coli O157:H7 str. Sakai 912391 NP_310301.1 CDS ECs2274 NC_002695.1 2245174 2245842 R hypothetical protein complement(2245174..2245842) Escherichia coli O157:H7 str. Sakai 912704 NP_944543.1 CDS ECs5457 NC_002695.1 2245764 2245943 R hypothetical protein complement(2245764..2245943) Escherichia coli O157:H7 str. Sakai 2693771 NP_310302.1 CDS ECs2275 NC_002695.1 2245969 2246709 R acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein complement(2245969..2246709) Escherichia coli O157:H7 str. Sakai 913391 NP_310303.1 CDS ECs2276 NC_002695.1 2246716 2247627 R similar to replication proteins e.g. [Bacteriophage phi-80] gi|137940|sp|P14815|VG15_BPPH8, hypothetical protein [Escherichia coli] gi|3025235|sp|P75978|YMFN_ECOLI; replication protein complement(2246716..2247627) Escherichia coli O157:H7 str. Sakai 913424 NP_310304.1 CDS ECs2277 NC_002695.1 2247701 2248126 R similar to hypothetical protein YdaY [Escherichia coli K-12] gi|3025103|sp|P76064|YDAT_ECOLI; hypothetical protein complement(2247701..2248126) Escherichia coli O157:H7 str. Sakai 914073 NP_310305.1 CDS ECs2278 NC_002695.1 2248123 2248425 R similar to hypothetical protein YdaS [Escherichia coli] gi|3025102|sp|P76063|YDAS_ECOLI; hypothetical protein complement(2248123..2248425) Escherichia coli O157:H7 str. Sakai 912332 NP_310306.1 CDS ECs2279 NC_002695.1 2248460 2248894 D similar to hypothetical protein b1145 [Escherichia coli cryptic prophage e14] gi|7444154|pir||F64859; hypothetical protein 2248460..2248894 Escherichia coli O157:H7 str. Sakai 912342 NP_310307.1 CDS ECs2280 NC_002695.1 2248879 2249106 D hypothetical protein 2248879..2249106 Escherichia coli O157:H7 str. Sakai 914005 NP_310308.1 CDS ECs2281 NC_002695.1 2249108 2249386 D similar to hypothetical protein [Rhizobium sp. NGR234] gi|2496690|sp|P55534|Y4KP_RHISN; hypothetical protein 2249108..2249386 Escherichia coli O157:H7 str. Sakai 913909 NP_310309.1 CDS ECs2282 NC_002695.1 2249591 2249755 D hypothetical protein 2249591..2249755 Escherichia coli O157:H7 str. Sakai 912398 NP_310310.1 CDS ECs2283 NC_002695.1 2249682 2250038 D hypothetical protein 2249682..2250038 Escherichia coli O157:H7 str. Sakai 912356 NP_944544.1 CDS ECs5458 NC_002695.1 2250110 2250328 D hypothetical protein 2250110..2250328 Escherichia coli O157:H7 str. Sakai 2693772 NP_310311.1 CDS ECs2284 NC_002695.1 2250897 2251085 D similar to DICB_ECOLI gi|1787857 (conserved in Escherichia coli K-12); inhibitor of cell division 2250897..2251085 Escherichia coli O157:H7 str. Sakai 914132 NP_310312.1 CDS ECs2285 NC_002695.1 2251082 2251273 D similar to YDFD_ECOLI gi|1787858; hypothetical protein 2251082..2251273 Escherichia coli O157:H7 str. Sakai 912445 NP_310313.1 CDS ECs2286 NC_002695.1 2251366 2253837 D similar to YDFE_ECOLI gi|1787859; hypothetical protein 2251366..2253837 Escherichia coli O157:H7 str. Sakai 914232 NP_310314.1 CDS ECs2287 NC_002695.1 2253910 2254161 D similar to excisionases e.g. [Bacteriophage VT2-Sa] dad|AP000363-2|BAA84285.1; excisionase 2253910..2254161 Escherichia coli O157:H7 str. Sakai 912393 NP_310315.1 CDS ECs2288 NC_002695.1 2255150 2255476 R similar to B1582_ECOLI gi|1787865 (conserved in Escherichia coli K-12); hypothetical protein complement(2255150..2255476) Escherichia coli O157:H7 str. Sakai 914350 NP_310316.1 CDS ECs2289 NC_002695.1 2255611 2255952 D similar to B1583_ECOLI gi|1787866 (conserved in Escherichia coli K-12); hypothetical protein 2255611..2255952 Escherichia coli O157:H7 str. Sakai 913979 NP_310317.1 CDS ECs2290 NC_002695.1 2255987 2256547 D similar to SPEG_ECOLI gi|1787867 (conserved in Escherichia coli K-12); spermidine N1-acetyltransferase 2255987..2256547 Escherichia coli O157:H7 str. Sakai 915270 NP_310318.2 CDS ECs2291 NC_002695.1 2256550 2257260 R similar to YNFC_ECOLI gi|1787868 (conserved in Escherichia coli K-12); hypothetical protein complement(2256550..2257260) Escherichia coli O157:H7 str. Sakai 912661 NP_310319.1 CDS ECs2292 NC_002695.1 2257365 2257673 D similar to B1586_ECOLI gi|1787869 (conserved in Escherichia coli K-12); hypothetical protein 2257365..2257673 Escherichia coli O157:H7 str. Sakai 913639 NP_310320.1 CDS ECs2293 NC_002695.1 2257872 2260298 D similar to B1587_ECOLI gi|1787870 (conserved in Escherichia coli K-12); oxidoreductase major subunit 2257872..2260298 Escherichia coli O157:H7 str. Sakai 912618 NP_310321.1 CDS ECs2294 NC_002695.1 2260356 2262782 D similar to B1588_ECOLI gi|1787871 (conserved in Escherichia coli K-12); oxidoreductase major subunit 2260356..2262782 Escherichia coli O157:H7 str. Sakai 912395 NP_310322.1 CDS ECs2295 NC_002695.1 2262793 2263410 D similar to DMSB_ECOLI gi|1787122 (conserved in Escherichia coli K-12); oxidoreductase Fe-S subunit 2262793..2263410 Escherichia coli O157:H7 str. Sakai 913903 NP_310323.1 CDS ECs2296 NC_002695.1 2263412 2264266 D similar to B1590_ECOLI gi|1787873 (conserved in Escherichia coli K-12); DMSO reductase anchor subunit 2263412..2264266 Escherichia coli O157:H7 str. Sakai 914008 NP_310324.2 CDS ECs2297 NC_002695.1 2264309 2264923 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 2264309..2264923 Escherichia coli O157:H7 str. Sakai 912340 NP_310325.2 CDS ECs2298 NC_002695.1 2265117 2266373 D similar to B1592_ECOLI gi|1787876 (conserved in Escherichia coli K-12); voltage-gated ClC-type chloride channel ClcB 2265117..2266373 Escherichia coli O157:H7 str. Sakai 916112 NP_310326.2 CDS bioD NC_002695.1 2266326 2267021 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(2266326..2267021) Escherichia coli O157:H7 str. Sakai 913895 NP_310327.1 CDS ECs2300 NC_002695.1 2267146 2268366 R similar to MLC_ECOLI gi|1787878 (conserved in Escherichia coli K-12); NAGC-like transcriptional regulator complement(2267146..2268366) Escherichia coli O157:H7 str. Sakai 913609 NP_310328.1 CDS ECs2301 NC_002695.1 2268501 2269394 R similar to YNFL_ECOLI gi|1787879 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(2268501..2269394) Escherichia coli O157:H7 str. Sakai 913369 NP_310329.1 CDS ECs2302 NC_002695.1 2269501 2270754 D similar to YNFM_ECOLI gi|1787880 (conserved in Escherichia coli K-12); transporter 2269501..2270754 Escherichia coli O157:H7 str. Sakai 913792 NP_310330.2 CDS ECs2303 NC_002695.1 2271178 2271486 D required for growth and survival under moderately acid conditions; acid shock protein 2271178..2271486 Escherichia coli O157:H7 str. Sakai 912800 NP_310331.1 CDS ECs2304 NC_002695.1 2271762 2272286 D similar to B1598_ECOLI gi|1787882 (conserved in Escherichia coli K-12); hypothetical protein 2271762..2272286 Escherichia coli O157:H7 str. Sakai 913241 NP_310332.1 CDS ECs2305 NC_002695.1 2272621 2272950 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(2272621..2272950) Escherichia coli O157:H7 str. Sakai 912405 NP_310333.1 CDS ECs2306 NC_002695.1 2272937 2273302 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(2272937..2273302) Escherichia coli O157:H7 str. Sakai 913399 NP_310334.1 CDS tqsA NC_002695.1 2273714 2274748 D transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 2273714..2274748 Escherichia coli O157:H7 str. Sakai 913758 NP_310335.1 CDS pntB NC_002695.1 2274773 2276161 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(2274773..2276161) Escherichia coli O157:H7 str. Sakai 913582 NP_310336.1 CDS pntA NC_002695.1 2276172 2277704 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(2276172..2277704) Escherichia coli O157:H7 str. Sakai 913908 NP_310337.1 CDS ECs2310 NC_002695.1 2278228 2279172 D similar to B1604_ECOLI gi|1787889 (conserved in Escherichia coli K-12); hypothetical protein 2278228..2279172 Escherichia coli O157:H7 str. Sakai 916933 NP_310338.1 CDS ECs2311 NC_002695.1 2279358 2280740 D similar to B1605_ECOLI gi|1787890 (conserved in Escherichia coli K-12); arginine/ornithine antiporter 2279358..2280740 Escherichia coli O157:H7 str. Sakai 916935 NP_310339.1 CDS ECs2312 NC_002695.1 2280777 2281499 D similar to YDGB_ECOLI gi|1787891 (conserved in Escherichia coli K-12); short chain dehydrogenase 2280777..2281499 Escherichia coli O157:H7 str. Sakai 916931 NP_310340.1 CDS ECs2313 NC_002695.1 2281496 2281831 R similar to YDGC_ECOLI gi|1787892 (conserved in Escherichia coli K-12); hypothetical protein complement(2281496..2281831) Escherichia coli O157:H7 str. Sakai 912634 NP_310341.1 CDS ECs2314 NC_002695.1 2281951 2282679 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 2281951..2282679 Escherichia coli O157:H7 str. Sakai 916930 NP_310342.1 CDS ECs2315 NC_002695.1 2282683 2283984 D similar to RSTB_ECOLI gi|1787894 (conserved in Escherichia coli K-12); sensor protein RstB 2282683..2283984 Escherichia coli O157:H7 str. Sakai 916932 NP_310343.1 CDS ECs2316 NC_002695.1 2284060 2284989 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 2284060..2284989 Escherichia coli O157:H7 str. Sakai 916928 NP_310344.1 CDS fumC NC_002695.1 2284986 2286389 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(2284986..2286389) Escherichia coli O157:H7 str. Sakai 913708 NP_310345.1 CDS ECs2318 NC_002695.1 2286532 2288178 R similar to FUMA_ECOLI gi|1787897 (conserved in Escherichia coli K-12); fumarase A complement(2286532..2288178) Escherichia coli O157:H7 str. Sakai 916929 NP_310346.1 CDS ECs2319 NC_002695.1 2288377 2289552 D similar to MANA_ECOLI gi|1787899 (conserved in Escherichia coli K-12); mannose-6-phosphate isomerase 2288377..2289552 Escherichia coli O157:H7 str. Sakai 916927 NP_310347.1 CDS ECs2320 NC_002695.1 2289653 2291161 D similar to YDGA_ECOLI gi|1787900 (conserved in Escherichia coli K-12); hypothetical protein 2289653..2291161 Escherichia coli O157:H7 str. Sakai 916939 NP_310350.1 CDS ECs2323 NC_002695.1 2292509 2293882 R similar to UIDB_ECOLI gi|1787902 (conserved in Escherichia coli K-12); glucuronide transporter complement(2292509..2293882) Escherichia coli O157:H7 str. Sakai 916921 NP_310353.1 CDS ECs2326 NC_002695.1 2296083 2296673 R similar to UIDR_ECOLI gi|1787904 (conserved in Escherichia coli K-12); repressor for uid operon complement(2296083..2296673) Escherichia coli O157:H7 str. Sakai 913631 NP_310354.1 CDS ECs2327 NC_002695.1 2296902 2297669 R Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(2296902..2297669) Escherichia coli O157:H7 str. Sakai 912528 NP_310355.1 CDS ECs2328 NC_002695.1 2297781 2298809 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(2297781..2298809) Escherichia coli O157:H7 str. Sakai 914202 NP_310356.1 CDS ECs2329 NC_002695.1 2298984 2300576 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 2298984..2300576 Escherichia coli O157:H7 str. Sakai 916922 NP_310357.1 CDS ECs2330 NC_002695.1 2300586 2301758 D similar to MALY_ECOLI gi|1787909 (conserved in Escherichia coli K-12); aminotrasferase 2300586..2301758 Escherichia coli O157:H7 str. Sakai 916923 NP_310358.1 CDS ECs2331 NC_002695.1 2301862 2302863 D catalyzes the formation of inosine from adenosine; adenosine deaminase 2301862..2302863 Escherichia coli O157:H7 str. Sakai 913624 NP_310359.2 CDS ECs2332 NC_002695.1 2302899 2303939 R similar to B1624_ECOLI gi|1787911 (conserved in Escherichia coli K-12); oxidoreductase complement(2302899..2303939) Escherichia coli O157:H7 str. Sakai 914048 NP_310360.1 CDS ECs2333 NC_002695.1 2304182 2304307 D similar to BLR_ECOLI gi|8953941 (conserved in Escherichia coli K-12); beta-lactam resistance protein 2304182..2304307 Escherichia coli O157:H7 str. Sakai 912438 NP_310361.1 CDS ECs2334 NC_002695.1 2304580 2304795 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 2304580..2304795 Escherichia coli O157:H7 str. Sakai 912671 NP_310362.1 CDS ECs2335 NC_002695.1 2304857 2305321 D similar to B1626_ECOLI gi|1787913 (conserved in Escherichia coli K-12); hypothetical protein 2304857..2305321 Escherichia coli O157:H7 str. Sakai 913795 NP_310363.1 CDS ECs2336 NC_002695.1 2305398 2305979 D similar to B1627_ECOLI gi|1787914 (conserved in Escherichia coli K-12); Na(+)-translocating NADH-quinone reductase subunit E 2305398..2305979 Escherichia coli O157:H7 str. Sakai 912291 NP_310364.1 CDS ECs2337 NC_002695.1 2305979 2306557 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 2305979..2306557 Escherichia coli O157:H7 str. Sakai 912556 NP_310365.1 CDS ECs2338 NC_002695.1 2306550 2308868 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 2306550..2308868 Escherichia coli O157:H7 str. Sakai 913456 NP_310366.1 CDS rnfD NC_002695.1 2308869 2309927 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 2308869..2309927 Escherichia coli O157:H7 str. Sakai 913023 NP_310367.1 CDS ECs2340 NC_002695.1 2309931 2310551 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 2309931..2310551 Escherichia coli O157:H7 str. Sakai 914445 NP_310368.1 CDS ECs2341 NC_002695.1 2310555 2311250 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 2310555..2311250 Escherichia coli O157:H7 str. Sakai 913729 NP_310369.1 CDS ECs2342 NC_002695.1 2311250 2311885 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 2311250..2311885 Escherichia coli O157:H7 str. Sakai 914029 NP_944545.1 CDS ECs5460 NC_002695.1 2312013 2312213 D hypothetical protein 2312013..2312213 Escherichia coli O157:H7 str. Sakai 2693793 NP_310370.1 CDS tppB NC_002695.1 2312496 2313998 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 2312496..2313998 Escherichia coli O157:H7 str. Sakai 912792 NP_310371.1 CDS ECs2344 NC_002695.1 2314104 2314709 D similar to GST_ECOLI gi|1787923 (conserved in Escherichia coli K-12); glutathionine S-transferase 2314104..2314709 Escherichia coli O157:H7 str. Sakai 914142 NP_310372.1 CDS ECs2345 NC_002695.1 2314753 2315616 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(2314753..2315616) Escherichia coli O157:H7 str. Sakai 912303 NP_310373.1 CDS ECs2346 NC_002695.1 2315675 2316949 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(2315675..2316949) Escherichia coli O157:H7 str. Sakai 913060 NP_310374.1 CDS ECs2347 NC_002695.1 2317078 2317734 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(2317078..2317734) Escherichia coli O157:H7 str. Sakai 912730 NP_310375.2 CDS ECs2348 NC_002695.1 2317793 2318116 R MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor complement(2317793..2318116) Escherichia coli O157:H7 str. Sakai 913759 NP_310376.1 CDS anmK NC_002695.1 2318220 2319329 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(2318220..2319329) Escherichia coli O157:H7 str. Sakai 912430 NP_310377.1 CDS ECs2350 NC_002695.1 2319602 2320069 D similar to SLYB_ECOLI gi|1787929 (conserved in Escherichia coli K-12); outer membrane protein 2319602..2320069 Escherichia coli O157:H7 str. Sakai 912692 NP_310378.2 CDS ECs2351 NC_002695.1 2320116 2320550 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(2320116..2320550) Escherichia coli O157:H7 str. Sakai 912735 NP_310379.1 CDS ECs2352 NC_002695.1 2320751 2320987 D similar to B1643_ECOLI gi|1787931 (conserved in Escherichia coli K-12); hypothetical protein 2320751..2320987 Escherichia coli O157:H7 str. Sakai 912804 NP_310380.2 CDS ECs2353 NC_002695.1 2320990 2321847 D similar to B1644_ECOLI gi|1787932 (conserved in Escherichia coli K-12); hypothetical protein 2320990..2321847 Escherichia coli O157:H7 str. Sakai 914262 NP_310381.1 CDS ECs2354 NC_002695.1 2321847 2323859 D similar to B1645_ECOLI gi|1787933 (conserved in Escherichia coli K-12); hypothetical protein 2321847..2323859 Escherichia coli O157:H7 str. Sakai 912808 NP_310382.1 CDS ECs2355 NC_002695.1 2323860 2324381 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(2323860..2324381) Escherichia coli O157:H7 str. Sakai 914926 NP_310383.1 CDS ECs2356 NC_002695.1 2324570 2325358 R similar to B1647_ECOLI gi|1787936; hypothetical protein complement(2324570..2325358) Escherichia coli O157:H7 str. Sakai 912527 NP_310384.1 CDS ECs2358 NC_002695.1 2325407 2325784 R similar to B1648_ECOLI gi|1787937 (conserved in Escherichia coli K-12); hypothetical protein complement(2325407..2325784) Escherichia coli O157:H7 str. Sakai 913574 NP_310385.1 CDS ECs2357 NC_002695.1 2325749 2326348 D similar to B1649_ECOLI gi|1787938 (conserved in Escherichia coli K-12); hypothetical protein 2325749..2326348 Escherichia coli O157:H7 str. Sakai 912319 NP_310386.1 CDS ECs2359 NC_002695.1 2326385 2327482 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 2326385..2327482 Escherichia coli O157:H7 str. Sakai 912715 NP_310387.1 CDS ECs2360 NC_002695.1 2327563 2327970 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 2327563..2327970 Escherichia coli O157:H7 str. Sakai 912789 NP_310388.1 CDS ECs2361 NC_002695.1 2328073 2328720 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 2328073..2328720 Escherichia coli O157:H7 str. Sakai 914111 NP_310389.1 CDS ECs2362 NC_002695.1 2328813 2333429 D similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 2328813..2333429 Escherichia coli O157:H7 str. Sakai 914010 NP_310390.1 CDS ECs2363 NC_002695.1 2333480 2333827 R similar to YDHD_ECOLI gi|1787943 (conserved in Escherichia coli K-12); hypothetical protein complement(2333480..2333827) Escherichia coli O157:H7 str. Sakai 912690 NP_310391.1 CDS ECs2364 NC_002695.1 2334162 2334977 D similar to YDHO_ECOLI gi|1787944 (conserved in Escherichia coli K-12); lipoprotein 2334162..2334977 Escherichia coli O157:H7 str. Sakai 912452 NP_310392.1 CDS ECs2365 NC_002695.1 2335105 2335686 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 2335105..2335686 Escherichia coli O157:H7 str. Sakai 912540 NP_310393.1 CDS ECs2366 NC_002695.1 2335832 2337001 R similar to B1657_ECOLI gi|1787947 (conserved in Escherichia coli K-12); transporter complement(2335832..2337001) Escherichia coli O157:H7 str. Sakai 912314 NP_310394.1 CDS ECs2367 NC_002695.1 2337555 2338580 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 2337555..2338580 Escherichia coli O157:H7 str. Sakai 912420 NP_310395.1 CDS ECs2368 NC_002695.1 2338577 2339509 R similar to YDHB_ECOLI gi|1787949 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator complement(2338577..2339509) Escherichia coli O157:H7 str. Sakai 912285 NP_310396.1 CDS ECs2369 NC_002695.1 2339622 2340833 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 2339622..2340833 Escherichia coli O157:H7 str. Sakai 914000 NP_310397.1 CDS ECs2370 NC_002695.1 2341124 2342272 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 2341124..2342272 Escherichia coli O157:H7 str. Sakai 912357 NP_310398.1 CDS ECs2371 NC_002695.1 2342312 2342953 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(2342312..2342953) Escherichia coli O157:H7 str. Sakai 912712 NP_310399.1 CDS ECs2372 NC_002695.1 2343168 2344541 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 2343168..2344541 Escherichia coli O157:H7 str. Sakai 912329 NP_310400.1 CDS ECs2373 NC_002695.1 2344582 2345838 R similar to B1664_ECOLI gi|1787954 (conserved in Escherichia coli K-12); hypothetical protein complement(2344582..2345838) Escherichia coli O157:H7 str. Sakai 912283 NP_310401.1 CDS ECs2374 NC_002695.1 2346411 2346716 D similar to B1667_ECOLI gi|1787956 (conserved in Escherichia coli K-12); hypothetical protein 2346411..2346716 Escherichia coli O157:H7 str. Sakai 912929 NP_310402.1 CDS ECs2375 NC_002695.1 2346842 2348446 D similar to B1668_ECOLI gi|1787957 (conserved in Escherichia coli K-12); hypothetical protein 2346842..2348446 Escherichia coli O157:H7 str. Sakai 913681 NP_310403.1 CDS ECs2376 NC_002695.1 2348458 2349270 R similar to B1669_ECOLI gi|1787958 (conserved in Escherichia coli K-12); hypothetical protein complement(2348458..2349270) Escherichia coli O157:H7 str. Sakai 913566 NP_310404.1 CDS ECs2377 NC_002695.1 2349274 2350059 R similar to YDHU_ECOLI gi|1787959 (conserved in Escherichia coli K-12); hypothetical protein complement(2349274..2350059) Escherichia coli O157:H7 str. Sakai 913750 NP_310405.1 CDS ECs2378 NC_002695.1 2350056 2350775 R similar to B1671_ECOLI gi|1787960 (conserved in Escherichia coli K-12); oxidoreductase Fe-S subunit complement(2350056..2350775) Escherichia coli O157:H7 str. Sakai 912453 NP_310406.1 CDS ECs2379 NC_002695.1 2350788 2351435 R similar to B1672_ECOLI gi|1787961 (conserved in Escherichia coli K-12); hypothetical protein complement(2350788..2351435) Escherichia coli O157:H7 str. Sakai 912520 NP_310407.1 CDS ECs2380 NC_002695.1 2351439 2353541 R similar to B1673_ECOLI gi|1787962 (conserved in Escherichia coli K-12); oxidoreductase complement(2351439..2353541) Escherichia coli O157:H7 str. Sakai 912714 NP_310408.1 CDS ECs2381 NC_002695.1 2353562 2354188 R similar to B1674_ECOLI gi|1787963 (conserved in Escherichia coli K-12); hypothetical protein complement(2353562..2354188) Escherichia coli O157:H7 str. Sakai 914273 NP_310409.1 CDS ECs2382 NC_002695.1 2354644 2354853 R similar to B1675_ECOLI gi|1787964 (conserved in Escherichia coli K-12); hypothetical protein complement(2354644..2354853) Escherichia coli O157:H7 str. Sakai 914156 NP_310410.1 CDS ECs2383 NC_002695.1 2355410 2356822 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2355410..2356822 Escherichia coli O157:H7 str. Sakai 913595 NP_310411.1 CDS ECs2384 NC_002695.1 2357133 2357369 D similar to LPP_ECOLI gi|1787967 (conserved in Escherichia coli K-12); murein lipoprotein 2357133..2357369 Escherichia coli O157:H7 str. Sakai 912531 NP_310412.1 CDS ECs2385 NC_002695.1 2357432 2358436 R similar to YNHG_ECOLI gi|1787968 (conserved in Escherichia coli K-12); hypothetical protein complement(2357432..2358436) Escherichia coli O157:H7 str. Sakai 913220 NP_310413.1 CDS ECs2386 NC_002695.1 2358585 2359001 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(2358585..2359001) Escherichia coli O157:H7 str. Sakai 912512 NP_310414.1 CDS ECs2387 NC_002695.1 2359014 2360234 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(2359014..2360234) Escherichia coli O157:H7 str. Sakai 913796 NP_310415.1 CDS ECs2388 NC_002695.1 2360231 2361502 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD complement(2360231..2361502) Escherichia coli O157:H7 str. Sakai 914034 NP_310416.1 CDS sufC NC_002695.1 2361477 2362223 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase complement(2361477..2362223) Escherichia coli O157:H7 str. Sakai 913187 NP_310417.2 CDS ECs2390 NC_002695.1 2362233 2363720 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(2362233..2363720) Escherichia coli O157:H7 str. Sakai 912410 NP_310418.1 CDS sufA NC_002695.1 2363729 2364097 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(2363729..2364097) Escherichia coli O157:H7 str. Sakai 914033 NP_310419.1 CDS ECs2392 NC_002695.1 2364646 2364915 R similar to B1685_ECOLI gi|1787975 (conserved in Escherichia coli K-12); hypothetical protein complement(2364646..2364915) Escherichia coli O157:H7 str. Sakai 914135 NP_310420.1 CDS ECs2393 NC_002695.1 2364934 2365344 R similar to B1686_ECOLI gi|1787976 (conserved in Escherichia coli K-12); hypothetical protein complement(2364934..2365344) Escherichia coli O157:H7 str. Sakai 912894 NP_310421.1 CDS ECs2394 NC_002695.1 2365341 2368397 R similar to YDIJ_ECOLI gi|1787977 (conserved in Escherichia coli K-12); oxidase complement(2365341..2368397) Escherichia coli O157:H7 str. Sakai 912417 NP_310422.1 CDS ECs2395 NC_002695.1 2368786 2369898 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 2368786..2369898 Escherichia coli O157:H7 str. Sakai 916554 NP_310423.1 CDS ECs2396 NC_002695.1 2370300 2370683 D similar to B1689_ECOLI gi|1787980 (conserved in Escherichia coli K-12); hypothetical protein 2370300..2370683 Escherichia coli O157:H7 str. Sakai 913865 NP_310424.1 CDS ECs2397 NC_002695.1 2370783 2371997 D similar to B1690_ECOLI gi|1787981 (conserved in Escherichia coli K-12); transport system permease 2370783..2371997 Escherichia coli O157:H7 str. Sakai 914046 NP_310425.1 CDS ECs2398 NC_002695.1 2372218 2373489 D similar to B1691_ECOLI gi|1787982 (conserved in Escherichia coli K-12); amino acid/amine transport protein 2372218..2373489 Escherichia coli O157:H7 str. Sakai 912697 NP_310426.1 CDS aroE NC_002695.1 2373501 2374367 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 2373501..2374367 Escherichia coli O157:H7 str. Sakai 912660 NP_310427.1 CDS aroD NC_002695.1 2374398 2375156 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 2374398..2375156 Escherichia coli O157:H7 str. Sakai 912629 NP_310428.1 CDS ECs2401 NC_002695.1 2375301 2376896 D similar to YDIF_ECOLI gi|1787985 (conserved in Escherichia coli K-12); hypothetical protein 2375301..2376896 Escherichia coli O157:H7 str. Sakai 912561 NP_310429.2 CDS ECs2402 NC_002695.1 2376910 2378061 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 2376910..2378061 Escherichia coli O157:H7 str. Sakai 914999 NP_310430.1 CDS ECs2403 NC_002695.1 2378104 2379015 R similar to B1696_ECOLI gi|1787987 (conserved in Escherichia coli K-12); AraC family transcriptional regulator complement(2378104..2379015) Escherichia coli O157:H7 str. Sakai 914907 NP_310431.1 CDS ECs2404 NC_002695.1 2379331 2380095 D YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 2379331..2380095 Escherichia coli O157:H7 str. Sakai 915310 NP_310432.1 CDS ECs2405 NC_002695.1 2380115 2381053 D May play a role in a redox process; electron transfer flavoprotein subunit YdiR 2380115..2381053 Escherichia coli O157:H7 str. Sakai 917031 NP_310433.1 CDS ECs2406 NC_002695.1 2381109 2382398 D similar to YDIS_ECOLI gi|1787991 (conserved in Escherichia coli K-12); hypothetical protein 2381109..2382398 Escherichia coli O157:H7 str. Sakai 912361 NP_310434.1 CDS ECs2407 NC_002695.1 2382395 2382688 D similar to YDIT_ECOLI gi|1787992 (conserved in Escherichia coli K-12); hypothetical protein 2382395..2382688 Escherichia coli O157:H7 str. Sakai 914182 NP_310435.2 CDS ECs2408 NC_002695.1 2382745 2384391 D acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 2382745..2384391 Escherichia coli O157:H7 str. Sakai 912954 NP_310436.1 CDS ECs2409 NC_002695.1 2384448 2386826 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(2384448..2386826) Escherichia coli O157:H7 str. Sakai 912913 NP_310437.1 CDS ECs2410 NC_002695.1 2387159 2387992 D similar to YDIA_ECOLI gi|1787995 (conserved in Escherichia coli K-12); hypothetical protein 2387159..2387992 Escherichia coli O157:H7 str. Sakai 914043 NP_310438.1 CDS ECs2411 NC_002695.1 2388149 2389195 D tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 2388149..2389195 Escherichia coli O157:H7 str. Sakai 912286 NP_310439.1 CDS ECs2412 NC_002695.1 2389327 2389518 D similar to YDIE_ECOLI gi|1787998 (conserved in Escherichia coli K-12); hypothetical protein 2389327..2389518 Escherichia coli O157:H7 str. Sakai 912284 NP_310440.1 CDS ECs2413 NC_002695.1 2389522 2390958 R similar to B1706_ECOLI gi|1787999 (conserved in Escherichia coli K-12); hypothetical protein complement(2389522..2390958) Escherichia coli O157:H7 str. Sakai 914103 NP_310441.1 CDS ECs2414 NC_002695.1 2391021 2391734 R similar to B1707_ECOLI gi|1788000 (conserved in Escherichia coli K-12); hypothetical protein complement(2391021..2391734) Escherichia coli O157:H7 str. Sakai 913205 NP_310442.1 CDS ECs2415 NC_002695.1 2391981 2392445 R similar to NLPC_ECOLI gi|1788001 (conserved in Escherichia coli K-12); lipoprotein complement(2391981..2392445) Escherichia coli O157:H7 str. Sakai 912287 NP_310443.1 CDS ECs2416 NC_002695.1 2392523 2393272 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(2392523..2393272) Escherichia coli O157:H7 str. Sakai 915033 NP_310444.1 CDS btuE NC_002695.1 2393272 2393823 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase complement(2393272..2393823) Escherichia coli O157:H7 str. Sakai 912713 NP_310445.1 CDS ECs2418 NC_002695.1 2393886 2394866 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(2393886..2394866) Escherichia coli O157:H7 str. Sakai 912333 NP_310446.1 CDS ihfA NC_002695.1 2394967 2395266 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(2394967..2395266) Escherichia coli O157:H7 str. Sakai 913811 NP_310447.1 CDS pheT NC_002695.1 2395271 2397658 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(2395271..2397658) Escherichia coli O157:H7 str. Sakai 912837 NP_310448.1 CDS pheS NC_002695.1 2397673 2398656 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(2397673..2398656) Escherichia coli O157:H7 str. Sakai 916567 NP_310450.1 CDS rplT NC_002695.1 2399106 2399462 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(2399106..2399462) Escherichia coli O157:H7 str. Sakai 912729 NP_310451.3 CDS rpmI NC_002695.1 2399515 2399712 R similar to RPMI_ECOLI gi|1788010 (conserved in Escherichia coli K-12); 50S ribosomal protein L35 complement(2399515..2399712) Escherichia coli O157:H7 str. Sakai 912347 NP_310452.1 CDS infC NC_002695.1 2399809 2400351 R IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 complement(2399809..2400351) Escherichia coli O157:H7 str. Sakai 913250 NP_310453.1 CDS ECs2426 NC_002695.1 2400355 2402283 R catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase complement(2400355..2402283) Escherichia coli O157:H7 str. Sakai 912923 NP_310454.1 CDS ECs2427 NC_002695.1 2402806 2404704 D similar to B1720_ECOLI gi|1788014, 1721_ECOLI gi|1788015; hypothetical protein 2402806..2404704 Escherichia coli O157:H7 str. Sakai 912976 NP_310455.1 CDS ECs2428 NC_002695.1 2405039 2405797 R similar to B1722_ECOLI gi|1788016 (conserved in Escherichia coli K-12); hypothetical protein complement(2405039..2405797) Escherichia coli O157:H7 str. Sakai 914231 NP_310456.2 CDS ECs2429 NC_002695.1 2406081 2407013 D similar to PFKB_ECOLI gi|1788017 (conserved in Escherichia coli K-12); 6-phosphofructokinase 2406081..2407013 Escherichia coli O157:H7 str. Sakai 917124 NP_310457.1 CDS ECs2430 NC_002695.1 2407114 2407404 D similar to B1724_ECOLI gi|1788018 (conserved in Escherichia coli K-12); hypothetical protein 2407114..2407404 Escherichia coli O157:H7 str. Sakai 916913 NP_310458.1 CDS ECs2431 NC_002695.1 2407510 2408370 D similar to B1725_ECOLI gi|1788019 (conserved in Escherichia coli K-12); hypothetical protein 2407510..2408370 Escherichia coli O157:H7 str. Sakai 913778 NP_310459.1 CDS ECs2432 NC_002695.1 2408411 2408947 R similar to B1726_ECOLI gi|1788020 (conserved in Escherichia coli K-12); hypothetical protein complement(2408411..2408947) Escherichia coli O157:H7 str. Sakai 915477 NP_310460.1 CDS ECs2433 NC_002695.1 2409094 2409762 D YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 2409094..2409762 Escherichia coli O157:H7 str. Sakai 912766 NP_310461.2 CDS ECs2434 NC_002695.1 2409925 2410515 D similar to B1728_ECOLI gi|1788023 (conserved in Escherichia coli K-12); hypothetical protein 2409925..2410515 Escherichia coli O157:H7 str. Sakai 912517 NP_310462.1 CDS ECs2435 NC_002695.1 2410648 2412039 D similar to B1729_ECOLI gi|1788024 (conserved in Escherichia coli K-12); hypothetical protein 2410648..2412039 Escherichia coli O157:H7 str. Sakai 916911 NP_310463.2 CDS ECs2436 NC_002695.1 2412090 2412857 R similar to B1730_ECOLI gi|1788025 (conserved in Escherichia coli K-12); hypothetical protein complement(2412090..2412857) Escherichia coli O157:H7 str. Sakai 917061 NP_310464.1 CDS ECs2437 NC_002695.1 2413134 2413397 R similar to B1731_ECOLI gi|1788026 (conserved in Escherichia coli K-12); cell division modulator complement(2413134..2413397) Escherichia coli O157:H7 str. Sakai 915364 NP_310465.1 CDS katE NC_002695.1 2413580 2415841 D Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 2413580..2415841 Escherichia coli O157:H7 str. Sakai 916912 NP_310466.1 CDS ECs2439 NC_002695.1 2415888 2416646 R similar to YDJC_ECOLI gi|1788028 (conserved in Escherichia coli K-12); hypothetical protein complement(2415888..2416646) Escherichia coli O157:H7 str. Sakai 914120 NP_310467.1 CDS ECs2440 NC_002695.1 2416659 2418011 R similar to CELF_ECOLI gi|1788029 (conserved in Escherichia coli K-12); 6-phospho-beta-glucosidase complement(2416659..2418011) Escherichia coli O157:H7 str. Sakai 914139 NP_310468.1 CDS ECs2441 NC_002695.1 2418117 2418959 R represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR complement(2418117..2418959) Escherichia coli O157:H7 str. Sakai 913124 NP_310469.1 CDS ECs2442 NC_002695.1 2418967 2419317 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA complement(2418967..2419317) Escherichia coli O157:H7 str. Sakai 916949 NP_310470.1 CDS ECs2443 NC_002695.1 2419368 2420726 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC complement(2419368..2420726) Escherichia coli O157:H7 str. Sakai 916938 NP_310471.1 CDS ECs2444 NC_002695.1 2420811 2421131 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB complement(2420811..2421131) Escherichia coli O157:H7 str. Sakai 912602 NP_310472.1 CDS ECs2445 NC_002695.1 2421431 2421769 R osmotically-inducible lipoprotein E; activator of ntr-like gene protein; OsmE family transcriptional regulator complement(2421431..2421769) Escherichia coli O157:H7 str. Sakai 912936 NP_310473.1 CDS nadE NC_002695.1 2421971 2422798 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2421971..2422798 Escherichia coli O157:H7 str. Sakai 916936 NP_310474.1 CDS ECs2447 NC_002695.1 2423028 2423915 D 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 2423028..2423915 Escherichia coli O157:H7 str. Sakai 912511 NP_310475.1 CDS ECs2448 NC_002695.1 2423875 2424513 R similar to B1742_ECOLI gi|1788038 (conserved in Escherichia coli K-12); hypothetical protein complement(2423875..2424513) Escherichia coli O157:H7 str. Sakai 917112 NP_310476.1 CDS ECs2449 NC_002695.1 2424653 2425138 R periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein complement(2424653..2425138) Escherichia coli O157:H7 str. Sakai 913975 NP_310477.1 CDS ECs2450 NC_002695.1 2425467 2426435 R catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase complement(2425467..2426435) Escherichia coli O157:H7 str. Sakai 917119 NP_310478.1 CDS ECs2451 NC_002695.1 2426428 2427771 R catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase complement(2426428..2427771) Escherichia coli O157:H7 str. Sakai 914117 NP_310479.1 CDS astD NC_002695.1 2427768 2429246 R a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase complement(2427768..2429246) Escherichia coli O157:H7 str. Sakai 917113 NP_310480.1 CDS ECs2453 NC_002695.1 2429243 2430277 R similar to B1747_ECOLI gi|1788043 (conserved in Escherichia coli K-12); arginine succinyltransferase complement(2429243..2430277) Escherichia coli O157:H7 str. Sakai 913079 NP_310481.1 CDS argD NC_002695.1 2430274 2431494 R catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase complement(2430274..2431494) Escherichia coli O157:H7 str. Sakai 917115 NP_310482.1 CDS ECs2455 NC_002695.1 2431940 2432746 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 2431940..2432746 Escherichia coli O157:H7 str. Sakai 912924 NP_310483.2 CDS ECs2456 NC_002695.1 2432913 2433623 D similar to YDJX_ECOLI gi|1788047 (conserved in Escherichia coli K-12); hypothetical protein 2432913..2433623 Escherichia coli O157:H7 str. Sakai 912631 NP_310484.2 CDS ECs2457 NC_002695.1 2433628 2434305 D similar to YDJY_ECOLI gi|1788048 (conserved in Escherichia coli K-12); hypothetical protein 2433628..2434305 Escherichia coli O157:H7 str. Sakai 913554 NP_310485.1 CDS ECs2458 NC_002695.1 2434320 2435027 D similar to YDJZ_ECOLI gi|1788049 (conserved in Escherichia coli K-12); hypothetical protein 2434320..2435027 Escherichia coli O157:H7 str. Sakai 917012 NP_310486.1 CDS ECs2459 NC_002695.1 2435027 2435575 D similar to YNJA_ECOLI gi|1788050 (conserved in Escherichia coli K-12); hypothetical protein 2435027..2435575 Escherichia coli O157:H7 str. Sakai 916971 NP_310487.1 CDS ECs2460 NC_002695.1 2435582 2436751 D similar to B1754_ECOLI gi|1788051 (conserved in Escherichia coli K-12); ABC transporter substrate-binding protein 2435582..2436751 Escherichia coli O157:H7 str. Sakai 914179 NP_310488.2 CDS ECs2461 NC_002695.1 2436724 2438259 D similar to B1755_ECOLI gi|1788052 (conserved in Escherichia coli K-12); transport system permease 2436724..2438259 Escherichia coli O157:H7 str. Sakai 914248 NP_310489.1 CDS ECs2462 NC_002695.1 2438259 2438912 D similar to B1756_ECOLI gi|1788053 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2438259..2438912 Escherichia coli O157:H7 str. Sakai 916952 NP_310490.2 CDS ECs2463 NC_002695.1 2438979 2440286 D similar to B1757_ECOLI gi|1788054 (conserved in Escherichia coli K-12); thiosulfate sulfur transferase 2438979..2440286 Escherichia coli O157:H7 str. Sakai 913022 NP_310491.1 CDS ECs2464 NC_002695.1 2440295 2440921 R similar to B1758_ECOLI gi|1788055 (conserved in Escherichia coli K-12); cytochrome oxidase complement(2440295..2440921) Escherichia coli O157:H7 str. Sakai 912581 NP_310492.1 CDS ECs2465 NC_002695.1 2441002 2441409 D similar to B1759_ECOLI gi|1788056 (conserved in Escherichia coli K-12); pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 2441002..2441409 Escherichia coli O157:H7 str. Sakai 914002 NP_310493.1 CDS ECs2466 NC_002695.1 2441375 2441647 R similar to B1760_ECOLI gi|1788057 (conserved in Escherichia coli K-12); hypothetical protein complement(2441375..2441647) Escherichia coli O157:H7 str. Sakai 916934 NP_310494.1 CDS ECs2467 NC_002695.1 2441883 2443226 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 2441883..2443226 Escherichia coli O157:H7 str. Sakai 917776 NP_310495.1 CDS ECs2468 NC_002695.1 2443343 2444383 R similar to B1762_ECOLI gi|1788060; hypothetical protein complement(2443343..2444383) Escherichia coli O157:H7 str. Sakai 917131 NP_310496.1 CDS ECs2469 NC_002695.1 2444511 2446472 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(2444511..2446472) Escherichia coli O157:H7 str. Sakai 917132 NP_310497.1 CDS ECs2470 NC_002695.1 2446477 2447520 R catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase complement(2446477..2447520) Escherichia coli O157:H7 str. Sakai 914210 NP_310498.1 CDS ECs2471 NC_002695.1 2447637 2448188 R similar to YDJA_ECOLI gi|1788063 (conserved in Escherichia coli K-12); hypothetical protein complement(2447637..2448188) Escherichia coli O157:H7 str. Sakai 916910 NP_310499.1 CDS ECs2472 NC_002695.1 2448349 2450205 D SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 2448349..2450205 Escherichia coli O157:H7 str. Sakai 917126 NP_310500.2 CDS ECs2473 NC_002695.1 2450309 2451031 D similar to hypothetical proteins e.g. CJ0034c [Campylobacter jejuni] gi|6967539|emb|CAB72527.1; lipoprotein 2450309..2451031 Escherichia coli O157:H7 str. Sakai 912674 NP_310501.1 CDS ansA NC_002695.1 2451163 2452179 D converts asparagine to aspartate and ammonia; asparaginase 2451163..2452179 Escherichia coli O157:H7 str. Sakai 916909 NP_310502.2 CDS ECs2475 NC_002695.1 2452190 2452831 D catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 2452190..2452831 Escherichia coli O157:H7 str. Sakai 917136 NP_310503.1 CDS ECs2476 NC_002695.1 2452924 2454174 R similar to YDJE_ECOLI gi|1788068; transporter complement(2452924..2454174) Escherichia coli O157:H7 str. Sakai 914154 NP_310504.1 CDS ECs2477 NC_002695.1 2454237 2454563 D OrfA protein of insertion sequence IS629; similar to hypothetical proteins e.g. TnpE [Shigella flexneri] gi|5532454|gb|AAD44738.1|AF141323_9; transposase 2454237..2454563 Escherichia coli O157:H7 str. Sakai 912346 NP_310505.1 CDS ECs2478 NC_002695.1 2454563 2455450 D OrfB protein of insertion sequence IS629; similar to transposase of IS629 gi|7443863|pir||T00315; transposase 2454563..2455450 Escherichia coli O157:H7 str. Sakai 914190 NP_310506.1 CDS ECs2479 NC_002695.1 2455713 2456471 R similar to B1770_ECOLI gi|1788069 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator complement(2455713..2456471) Escherichia coli O157:H7 str. Sakai 913658 NP_310507.1 CDS ECs2480 NC_002695.1 2456608 2457588 R similar to B1771_ECOLI gi|1788070 (conserved in Escherichia coli K-12); hypothetical protein complement(2456608..2457588) Escherichia coli O157:H7 str. Sakai 913782 NP_310508.1 CDS ECs2481 NC_002695.1 2457598 2458530 R similar to B1772_ECOLI gi|1788071 (conserved in Escherichia coli K-12); kinase complement(2457598..2458530) Escherichia coli O157:H7 str. Sakai 914258 NP_310509.1 CDS ECs2482 NC_002695.1 2458535 2459371 R similar to B1773_ECOLI gi|1788072 (conserved in Escherichia coli K-12); aldolase complement(2458535..2459371) Escherichia coli O157:H7 str. Sakai 912677 NP_310510.1 CDS ECs2483 NC_002695.1 2459392 2460435 R similar to YDJJ_ECOLI gi|1788073 (conserved in Escherichia coli K-12); oxidoreductase complement(2459392..2460435) Escherichia coli O157:H7 str. Sakai 912814 NP_310511.1 CDS ECs2484 NC_002695.1 2460452 2461831 R similar to B1775_ECOLI gi|1788074 (conserved in Escherichia coli K-12); transporter complement(2460452..2461831) Escherichia coli O157:H7 str. Sakai 913715 NP_310512.1 CDS ECs2485 NC_002695.1 2461858 2462934 R similar to B1776_ECOLI gi|1788075 (conserved in Escherichia coli K-12); oxidoreductase complement(2461858..2462934) Escherichia coli O157:H7 str. Sakai 913710 NP_310513.2 CDS ECs2486 NC_002695.1 2463304 2463576 R similar to B1777_ECOLI gi|1788076 (conserved in Escherichia coli K-12); hypothetical protein complement(2463304..2463576) Escherichia coli O157:H7 str. Sakai 912822 NP_310514.1 CDS ECs2487 NC_002695.1 2463618 2464031 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(2463618..2464031) Escherichia coli O157:H7 str. Sakai 912866 NP_310515.1 CDS ECs2488 NC_002695.1 2464373 2465368 D catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 2464373..2465368 Escherichia coli O157:H7 str. Sakai 913285 NP_310516.2 CDS ECs2489 NC_002695.1 2465452 2466336 D similar to YEAD_ECOLI gi|1788080 (conserved in Escherichia coli K-12); hypothetical protein 2465452..2466336 Escherichia coli O157:H7 str. Sakai 915156 NP_310517.1 CDS ECs2490 NC_002695.1 2466387 2467241 R similar to B1781_ECOLI gi|1788081 (conserved in Escherichia coli K-12); aldehyde reductase complement(2466387..2467241) Escherichia coli O157:H7 str. Sakai 912745 NP_310518.1 CDS ECs2491 NC_002695.1 2467331 2468077 R similar to MIPA_ECOLI gi|1788082 (conserved in Escherichia coli K-12); scaffolding protein in the formation of a murein-synthesizing holoenzyme complement(2467331..2468077) Escherichia coli O157:H7 str. Sakai 912705 NP_310519.1 CDS ECs2492 NC_002695.1 2468513 2470447 D similar to YEAG_ECOLI gi|1788083 (conserved in Escherichia coli K-12); hypothetical protein 2468513..2470447 Escherichia coli O157:H7 str. Sakai 913722 NP_310520.1 CDS ECs2493 NC_002695.1 2470560 2471843 D similar to YEAH_ECOLI gi|1788084 (conserved in Escherichia coli K-12); hypothetical protein 2470560..2471843 Escherichia coli O157:H7 str. Sakai 912737 NP_310521.1 CDS ECs2494 NC_002695.1 2472122 2473465 D similar to YEAI_ECOLI gi|1788085 (conserved in Escherichia coli K-12); hypothetical protein 2472122..2473465 Escherichia coli O157:H7 str. Sakai 912853 NP_310522.2 CDS ECs2495 NC_002695.1 2473646 2475136 D similar to YEAJ_ECOLI gi|1788086 (conserved in Escherichia coli K-12); hypothetical protein 2473646..2475136 Escherichia coli O157:H7 str. Sakai 912760 NP_310523.1 CDS ECs2496 NC_002695.1 2475179 2475682 D similar to YEAK_ECOLI gi|1788087 (conserved in Escherichia coli K-12); hypothetical protein 2475179..2475682 Escherichia coli O157:H7 str. Sakai 912573 NP_310524.1 CDS ECs2497 NC_002695.1 2475683 2475835 R similar to B1788_ECOLI gi|1788088 (conserved in Escherichia coli K-12); hypothetical protein complement(2475683..2475835) Escherichia coli O157:H7 str. Sakai 912755 NP_310525.1 CDS ECs2498 NC_002695.1 2475957 2476403 D similar to YEAL_ECOLI gi|1788090 (conserved in Escherichia coli K-12); hypothetical protein 2475957..2476403 Escherichia coli O157:H7 str. Sakai 913210 NP_310526.1 CDS ECs2499 NC_002695.1 2476360 2477181 R similar to YEAM_ECOLI gi|1788091 (conserved in Escherichia coli K-12); AraC family transcriptional regulator complement(2476360..2477181) Escherichia coli O157:H7 str. Sakai 913951 NP_310527.1 CDS ECs2500 NC_002695.1 2477278 2478459 D similar to YEAN_ECOLI gi|1788092 (conserved in Escherichia coli K-12); amino acid/amine transport protein 2477278..2478459 Escherichia coli O157:H7 str. Sakai 913931 NP_310528.2 CDS ECs2501 NC_002695.1 2478514 2478861 D similar to YEAO_ECOLI gi|1788093 (conserved in Escherichia coli K-12); hypothetical protein 2478514..2478861 Escherichia coli O157:H7 str. Sakai 913675 NP_310529.1 CDS ECs2502 NC_002695.1 2478883 2479137 R similar to YOAF_ECOLI gi|1788094 (conserved in Escherichia coli K-12); hypothetical protein complement(2478883..2479137) Escherichia coli O157:H7 str. Sakai 913358 NP_310530.1 CDS ECs2503 NC_002695.1 2479320 2480168 D similar to YAEP_ECOLI gi|1788095 (conserved in Escherichia coli K-12); hypothetical protein 2479320..2480168 Escherichia coli O157:H7 str. Sakai 913888 NP_310531.1 CDS ECs2504 NC_002695.1 2480612 2480860 R similar to YEAQ_ECOLI gi|1788096 (conserved in Escherichia coli K-12); hypothetical protein complement(2480612..2480860) Escherichia coli O157:H7 str. Sakai 913024 NP_310532.1 CDS ECs2505 NC_002695.1 2481007 2481189 R similar to YOAG_ECOLI gi|1788097 (conserved in Escherichia coli K-12); hypothetical protein complement(2481007..2481189) Escherichia coli O157:H7 str. Sakai 916565 NP_310533.1 CDS ECs2506 NC_002695.1 2481193 2481552 R similar to YEAR_ECOLI gi|1788098 (conserved in Escherichia coli K-12); hypothetical protein complement(2481193..2481552) Escherichia coli O157:H7 str. Sakai 914119 NP_310534.1 CDS ECs2507 NC_002695.1 2481725 2482363 R similar to YEAS_ECOLI gi|1788099 (conserved in Escherichia coli K-12); leucine export protein LeuE complement(2481725..2482363) Escherichia coli O157:H7 str. Sakai 912651 NP_310535.2 CDS ECs2508 NC_002695.1 2482490 2483413 R similar to YEAT_ECOLI gi|1788100 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(2482490..2483413) Escherichia coli O157:H7 str. Sakai 913737 NP_310536.1 CDS ECs2509 NC_002695.1 2483516 2484601 D similar to YEAU_ECOLI gi|1788101 (conserved in Escherichia coli K-12); tartrate dehydrogenase 2483516..2484601 Escherichia coli O157:H7 str. Sakai 914239 NP_310537.1 CDS ECs2510 NC_002695.1 2485017 2486462 D member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 2485017..2486462 Escherichia coli O157:H7 str. Sakai 912973 NP_310538.1 CDS ECs2511 NC_002695.1 2486494 2487618 D similar to YEAW_ECOLI gi|1788103 (conserved in Escherichia coli K-12); hypothetical protein 2486494..2487618 Escherichia coli O157:H7 str. Sakai 912476 NP_310539.1 CDS ECs2512 NC_002695.1 2487674 2488639 D similar to YEAX_ECOLI gi|1788104 (conserved in Escherichia coli K-12); diogenase subunit beta 2487674..2488639 Escherichia coli O157:H7 str. Sakai 912664 NP_310540.1 CDS ECs2513 NC_002695.1 2488693 2489820 R similar to RND_ECOLI gi|1788105 (conserved in Escherichia coli K-12); ribonuclease D complement(2488693..2489820) Escherichia coli O157:H7 str. Sakai 913837 NP_310541.1 CDS ECs2514 NC_002695.1 2489890 2491575 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(2489890..2491575) Escherichia coli O157:H7 str. Sakai 912449 NP_310542.1 CDS ECs2515 NC_002695.1 2491780 2492361 R similar to B1806_ECOLI gi|1788108 (conserved in Escherichia coli K-12); outer membrane protein complement(2491780..2492361) Escherichia coli O157:H7 str. Sakai 912846 NP_310543.1 CDS ECs2516 NC_002695.1 2492401 2493096 R similar to YEAZ_ECOLI gi|1788109 (conserved in Escherichia coli K-12); hypothetical protein complement(2492401..2493096) Escherichia coli O157:H7 str. Sakai 915193 NP_310544.1 CDS ECs2517 NC_002695.1 2493154 2495064 R similar to B1808_ECOLI gi|1788110 (conserved in Escherichia coli K-12); hypothetical protein complement(2493154..2495064) Escherichia coli O157:H7 str. Sakai 912798 NP_310545.1 CDS ECs2518 NC_002695.1 2495148 2495540 D similar to B1809_ECOLI gi|1788111 (conserved in Escherichia coli K-12); hypothetical protein 2495148..2495540 Escherichia coli O157:H7 str. Sakai 912885 NP_310546.1 CDS ECs2519 NC_002695.1 2495902 2496261 D similar to B1810_ECOLI gi|1788112 (conserved in Escherichia coli K-12); hypothetical protein 2495902..2496261 Escherichia coli O157:H7 str. Sakai 912709 NP_310547.1 CDS ECs2520 NC_002695.1 2496381 2496560 R similar to B1811_ECOLI gi|1788113 (conserved in Escherichia coli K-12); hypothetical protein complement(2496381..2496560) Escherichia coli O157:H7 str. Sakai 912673 NP_310548.1 CDS ECs2521 NC_002695.1 2496634 2497995 D catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 2496634..2497995 Escherichia coli O157:H7 str. Sakai 914166 NP_310549.1 CDS ECs2522 NC_002695.1 2497999 2498577 D similar to YEAB_ECOLI gi|1788115 (conserved in Escherichia coli K-12); hypothetical protein 2497999..2498577 Escherichia coli O157:H7 str. Sakai 912636 NP_310550.1 CDS ECs2523 NC_002695.1 2498761 2500125 D similar to SDAA_ECOLI gi|1788116 (conserved in Escherichia coli K-12); L-serine dehydratase 1 2498761..2500125 Escherichia coli O157:H7 str. Sakai 912552 NP_310551.1 CDS ECs2524 NC_002695.1 2500226 2501854 D similar to B1815_ECOLI gi|1788118 (conserved in Escherichia coli K-12); hypothetical protein 2500226..2501854 Escherichia coli O157:H7 str. Sakai 912289 NP_310552.1 CDS ECs2525 NC_002695.1 2501858 2503414 R similar to YOAE_ECOLI gi|1788119 (conserved in Escherichia coli K-12); transporter complement(2501858..2503414) Escherichia coli O157:H7 str. Sakai 914066 NP_310553.1 CDS ECs2526 NC_002695.1 2503402 2503611 R hypothetical protein complement(2503402..2503611) Escherichia coli O157:H7 str. Sakai 916568 NP_310554.1 CDS ECs2527 NC_002695.1 2503877 2504848 D similar to MANX_ECOLI gi|1788120 (conserved in Escherichia coli K-12); PTS system mannose-specific transporter subunit IIAB 2503877..2504848 Escherichia coli O157:H7 str. Sakai 912501 NP_310555.1 CDS ECs2528 NC_002695.1 2504911 2505711 D similar to MANY_ECOLI gi|1788121 (conserved in Escherichia coli K-12); mannose-specific PTS enzyme IIC 2504911..2505711 Escherichia coli O157:H7 str. Sakai 912707 NP_310556.3 CDS ECs2529 NC_002695.1 2505715 2506575 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2505715..2506575 Escherichia coli O157:H7 str. Sakai 914171 NP_310557.1 CDS ECs2530 NC_002695.1 2506630 2507088 D similar to B1820_ECOLI gi|1788123 (conserved in Escherichia coli K-12); hypothetical protein 2506630..2507088 Escherichia coli O157:H7 str. Sakai 912870 NP_310558.1 CDS ECs2531 NC_002695.1 2507464 2508084 D membrane protein YebN; hypothetical protein 2507464..2508084 Escherichia coli O157:H7 str. Sakai 913981 NP_310559.1 CDS rrmA NC_002695.1 2508081 2508890 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase complement(2508081..2508890) Escherichia coli O157:H7 str. Sakai 912722 NP_310560.1 CDS ECs2533 NC_002695.1 2509056 2509265 R similar to CSPC_ECOLI gi|1788126 (conserved in Escherichia coli K-12); cold shock-like protein CspC complement(2509056..2509265) Escherichia coli O157:H7 str. Sakai 912295 NP_310561.1 CDS ECs2534 NC_002695.1 2509278 2509421 R similar to B1824_ECOLI gi|1788127 (conserved in Escherichia coli K-12); hypothetical protein complement(2509278..2509421) Escherichia coli O157:H7 str. Sakai 913814 NP_310562.1 CDS ECs2535 NC_002695.1 2510090 2510377 R similar to B1825_ECOLI gi|1788128 (conserved in Escherichia coli K-12); hypothetical protein complement(2510090..2510377) Escherichia coli O157:H7 str. Sakai 912296 NP_310563.1 CDS ECs2536 NC_002695.1 2510452 2510595 R similar to B1826_ECOLI gi|1788130 (conserved in Escherichia coli K-12); hypothetical protein complement(2510452..2510595) Escherichia coli O157:H7 str. Sakai 913625 NP_944546.1 CDS ECs5463 NC_002695.1 2510779 2510994 D hypothetical protein 2510779..2510994 Escherichia coli O157:H7 str. Sakai 2693823 NP_310564.1 CDS ECs2537 NC_002695.1 2511138 2511929 R similar to B1827_ECOLI gi|1788131 (conserved in Escherichia coli K-12); regulator complement(2511138..2511929) Escherichia coli O157:H7 str. Sakai 912739 NP_310565.2 CDS ECs2538 NC_002695.1 2512106 2513479 D similar to B1828_ECOLI gi|1788132 (conserved in Escherichia coli K-12); transporter 2512106..2513479 Escherichia coli O157:H7 str. Sakai 912795 NP_310566.1 CDS ECs2539 NC_002695.1 2513525 2514406 R metalloprotease; heat shock protein HtpX complement(2513525..2514406) Escherichia coli O157:H7 str. Sakai 912682 NP_310567.1 CDS ECs2540 NC_002695.1 2514598 2516646 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(2514598..2516646) Escherichia coli O157:H7 str. Sakai 912964 NP_310568.1 CDS ECs2541 NC_002695.1 2516666 2517364 R affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector complement(2516666..2517364) Escherichia coli O157:H7 str. Sakai 912783 NP_310569.2 CDS ECs2542 NC_002695.1 2517461 2517958 R similar to B1832_ECOLI gi|1788136 (conserved in Escherichia coli K-12); hypothetical protein complement(2517461..2517958) Escherichia coli O157:H7 str. Sakai 915160 NP_310570.1 CDS ECs2543 NC_002695.1 2518088 2519371 D similar to B1833_ECOLI gi|1788137 (conserved in Escherichia coli K-12); hypothetical protein 2518088..2519371 Escherichia coli O157:H7 str. Sakai 912855 NP_310571.1 CDS ECs2544 NC_002695.1 2519334 2521973 D similar to B1834_ECOLI gi|1788138 (conserved in Escherichia coli K-12); hypothetical protein 2519334..2521973 Escherichia coli O157:H7 str. Sakai 914177 NP_310572.1 CDS yebU NC_002695.1 2522048 2523493 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2522048..2523493 Escherichia coli O157:H7 str. Sakai 915363 NP_310573.1 CDS ECs2546 NC_002695.1 2523596 2523847 D similar to B1836_ECOLI gi|1788141 (conserved in Escherichia coli K-12); hypothetical protein 2523596..2523847 Escherichia coli O157:H7 str. Sakai 914904 NP_310574.1 CDS ECs2547 NC_002695.1 2523868 2524143 D similar to B1837_ECOLI gi|1788142 (conserved in Escherichia coli K-12); hypothetical protein 2523868..2524143 Escherichia coli O157:H7 str. Sakai 914875 NP_310575.2 CDS pphA NC_002695.1 2524144 2524800 R Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 complement(2524144..2524800) Escherichia coli O157:H7 str. Sakai 912809 NP_310576.1 CDS ECs2549 NC_002695.1 2525196 2525537 R similar to B1839_ECOLI gi|1788144 (conserved in Escherichia coli K-12); hypothetical protein complement(2525196..2525537) Escherichia coli O157:H7 str. Sakai 915046 NP_310577.1 CDS ECs2550 NC_002695.1 2525550 2526422 R similar to B1840_ECOLI gi|1788145 (conserved in Escherichia coli K-12); resistance protein complement(2525550..2526422) Escherichia coli O157:H7 str. Sakai 912377 NP_310578.1 CDS ECs2551 NC_002695.1 2526426 2526800 R similar to B1841_ECOLI gi|1788146 (conserved in Escherichia coli K-12); hypothetical protein complement(2526426..2526800) Escherichia coli O157:H7 str. Sakai 914269 NP_310579.1 CDS ECs2552 NC_002695.1 2526939 2527169 D similar to HOLE_ECOLI gi|1788147 (conserved in Escherichia coli K-12); DNA polymerase III subunit theta 2526939..2527169 Escherichia coli O157:H7 str. Sakai 913059 NP_310580.1 CDS ECs2553 NC_002695.1 2527271 2527927 D similar to B1843_ECOLI gi|1788148 (conserved in Escherichia coli K-12); hypothetical protein 2527271..2527927 Escherichia coli O157:H7 str. Sakai 913638 NP_310581.1 CDS ECs2554 NC_002695.1 2527951 2528613 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2527951..2528613 Escherichia coli O157:H7 str. Sakai 913055 NP_310582.1 CDS ECs2555 NC_002695.1 2528610 2530670 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(2528610..2530670) Escherichia coli O157:H7 str. Sakai 912379 NP_310583.1 CDS ECs2556 NC_002695.1 2530879 2531538 R similar to YEBE_ECOLI gi|1788151 (conserved in Escherichia coli K-12); hypothetical protein complement(2530879..2531538) Escherichia coli O157:H7 str. Sakai 913246 NP_310584.1 CDS ECs2557 NC_002695.1 2531865 2532233 R secreted protein; unknown function; hypothetical protein complement(2531865..2532233) Escherichia coli O157:H7 str. Sakai 914104 NP_310585.1 CDS ECs2558 NC_002695.1 2532288 2532578 R similar to YEBG_ECOLI gi|1788153 (conserved in Escherichia coli K-12); DNA damage-inducible protein YebG complement(2532288..2532578) Escherichia coli O157:H7 str. Sakai 912752 NP_310586.1 CDS purT NC_002695.1 2532712 2533890 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2532712..2533890 Escherichia coli O157:H7 str. Sakai 912498 NP_310587.1 CDS ECs2560 NC_002695.1 2533946 2534587 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(2533946..2534587) Escherichia coli O157:H7 str. Sakai 912650 NP_310588.1 CDS ECs2561 NC_002695.1 2534624 2536435 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(2534624..2536435) Escherichia coli O157:H7 str. Sakai 912867 NP_310589.1 CDS ECs2562 NC_002695.1 2536670 2538145 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(2536670..2538145) Escherichia coli O157:H7 str. Sakai 912956 NP_310590.1 CDS ECs2563 NC_002695.1 2538483 2539352 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2538483..2539352 Escherichia coli O157:H7 str. Sakai 912646 NP_310591.1 CDS ECs2564 NC_002695.1 2539480 2540922 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2539480..2540922 Escherichia coli O157:H7 str. Sakai 913541 NP_310592.1 CDS ECs2565 NC_002695.1 2541053 2542024 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(2541053..2542024) Escherichia coli O157:H7 str. Sakai 913553 NP_310593.2 CDS ECs2566 NC_002695.1 2542144 2543466 R similar to YEBA_ECOLI gi|1788162 (conserved in Escherichia coli K-12); hypothetical protein complement(2542144..2543466) Escherichia coli O157:H7 str. Sakai 913569 NP_310594.3 CDS znuA NC_002695.1 2543482 2544414 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein complement(2543482..2544414) Escherichia coli O157:H7 str. Sakai 912362 NP_310595.1 CDS znuC NC_002695.1 2544493 2545248 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2544493..2545248 Escherichia coli O157:H7 str. Sakai 913529 NP_310596.1 CDS znuB NC_002695.1 2545245 2546030 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2545245..2546030 Escherichia coli O157:H7 str. Sakai 916919 NP_310597.1 CDS ruvB NC_002695.1 2546276 2547286 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2546276..2547286) Escherichia coli O157:H7 str. Sakai 913568 NP_310598.1 CDS ruvA NC_002695.1 2547295 2547906 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2547295..2547906) Escherichia coli O157:H7 str. Sakai 913515 NP_310599.2 CDS ECs2572 NC_002695.1 2548181 2548783 D similar to YEBB_ECOLI gi|1788169 (conserved in Escherichia coli K-12); hypothetical protein 2548181..2548783 Escherichia coli O157:H7 str. Sakai 913539 NP_310600.1 CDS ruvC NC_002695.1 2548785 2549306 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2548785..2549306) Escherichia coli O157:H7 str. Sakai 912572 NP_310601.1 CDS ECs2574 NC_002695.1 2549341 2550081 R similar to YEBC_ECOLI gi|1788171 (conserved in Escherichia coli K-12); hypothetical protein complement(2549341..2550081) Escherichia coli O157:H7 str. Sakai 912378 NP_310602.1 CDS ntpA NC_002695.1 2550110 2550562 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(2550110..2550562) Escherichia coli O157:H7 str. Sakai 914189 NP_310603.1 CDS aspS NC_002695.1 2550680 2552452 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2550680..2552452) Escherichia coli O157:H7 str. Sakai 914186 NP_310604.2 CDS ECs2577 NC_002695.1 2552762 2553328 D similar to YECD_ECOLI gi|1788174 (conserved in Escherichia coli K-12); hypothetical protein 2552762..2553328 Escherichia coli O157:H7 str. Sakai 914157 NP_310605.1 CDS ECs2578 NC_002695.1 2553325 2554143 D similar to YECE_ECOLI gi|1788175 (conserved in Escherichia coli K-12); hypothetical protein 2553325..2554143 Escherichia coli O157:H7 str. Sakai 913980 NP_310606.2 CDS ECs2579 NC_002695.1 2554196 2554591 D similar to YECN_ECOLI gi|1788176 (conserved in Escherichia coli K-12); hypothetical protein 2554196..2554591 Escherichia coli O157:H7 str. Sakai 913033 NP_310607.1 CDS ECs2580 NC_002695.1 2554632 2555375 D similar to YECO_ECOLI gi|1788177 (conserved in Escherichia coli K-12); hypothetical protein 2554632..2555375 Escherichia coli O157:H7 str. Sakai 912510 NP_310608.1 CDS ECs2581 NC_002695.1 2555372 2556343 D similar to YECP_ECOLI gi|1788178 (conserved in Escherichia coli K-12); hypothetical protein 2555372..2556343 Escherichia coli O157:H7 str. Sakai 914170 NP_310609.2 CDS ECs2582 NC_002695.1 2556508 2558937 R similar to BISZ_ECOLI gi|1788180 (conserved in Escherichia coli K-12); biotin sulfoxide reductase complement(2556508..2558937) Escherichia coli O157:H7 str. Sakai 914087 NP_310610.1 CDS ECs2583 NC_002695.1 2558962 2560062 R similar to YECK_ECOLI gi|1788181 (conserved in Escherichia coli K-12); cytochrome C-type protein complement(2558962..2560062) Escherichia coli O157:H7 str. Sakai 912611 NP_310611.2 CDS ECs2584 NC_002695.1 2560450 2561196 R similar to CUTC_ECOLI gi|1788182 (conserved in Escherichia coli K-12); copper homeostasis protein CutC complement(2560450..2561196) Escherichia coli O157:H7 str. Sakai 912830 NP_310612.2 CDS ECs2585 NC_002695.1 2561210 2561776 R similar to YECM_ECOLI gi|1788183 (conserved in Escherichia coli K-12); hypothetical protein complement(2561210..2561776) Escherichia coli O157:H7 str. Sakai 913954 NP_310613.1 CDS argS NC_002695.1 2561992 2563725 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2561992..2563725 Escherichia coli O157:H7 str. Sakai 912519 NP_310614.1 CDS ECs2587 NC_002695.1 2563902 2564390 D similar to YECT_ECOLI gi|1788185 (conserved in Escherichia coli K-12); hypothetical protein 2563902..2564390 Escherichia coli O157:H7 str. Sakai 913572 NP_310615.1 CDS ECs2588 NC_002695.1 2564510 2564902 R similar to FLHE_ECOLI gi|1788186 (conserved in Escherichia coli K-12); flagellar protein complement(2564510..2564902) Escherichia coli O157:H7 str. Sakai 912570 NP_310616.1 CDS flhA NC_002695.1 2564902 2566980 R membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA complement(2564902..2566980) Escherichia coli O157:H7 str. Sakai 914214 NP_310617.1 CDS flhB NC_002695.1 2566973 2568121 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(2566973..2568121) Escherichia coli O157:H7 str. Sakai 912385 NP_310618.1 CDS ECs2591 NC_002695.1 2568323 2568967 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis protein CheZ complement(2568323..2568967) Escherichia coli O157:H7 str. Sakai 912565 NP_310619.1 CDS ECs2592 NC_002695.1 2568978 2569367 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(2568978..2569367) Escherichia coli O157:H7 str. Sakai 914203 NP_310620.1 CDS ECs2593 NC_002695.1 2569382 2570431 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(2569382..2570431) Escherichia coli O157:H7 str. Sakai 913533 NP_310621.1 CDS ECs2594 NC_002695.1 2570434 2571294 R methylates the MCP; chemotaxis methyltransferase CheR complement(2570434..2571294) Escherichia coli O157:H7 str. Sakai 914148 NP_310622.1 CDS ECs2595 NC_002695.1 2571313 2572914 R mediates taxis toward dipeptides; methyl-accepting protein IV complement(2571313..2572914) Escherichia coli O157:H7 str. Sakai 914196 NP_310623.1 CDS ECs2596 NC_002695.1 2572960 2574621 R similar to TAR_ECOLI gi|1788195 (conserved in Escherichia coli K-12); methyl-accepting chemotaxis protein II complement(2572960..2574621) Escherichia coli O157:H7 str. Sakai 914160 NP_310624.1 CDS ECs2597 NC_002695.1 2574764 2575267 R similar to CHEW_ECOLI gi|1788196 (conserved in Escherichia coli K-12); purine-binding chemotaxis protein complement(2574764..2575267) Escherichia coli O157:H7 str. Sakai 914106 NP_310625.1 CDS ECs2598 NC_002695.1 2575288 2577252 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(2575288..2577252) Escherichia coli O157:H7 str. Sakai 914221 NP_310626.1 CDS motB NC_002695.1 2577257 2578183 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(2577257..2578183) Escherichia coli O157:H7 str. Sakai 912569 NP_310627.1 CDS ECs2600 NC_002695.1 2578180 2579067 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(2578180..2579067) Escherichia coli O157:H7 str. Sakai 912582 NP_310628.1 CDS ECs2601 NC_002695.1 2579194 2579772 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(2579194..2579772) Escherichia coli O157:H7 str. Sakai 913689 NP_310629.2 CDS ECs2602 NC_002695.1 2579775 2580125 R with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(2579775..2580125) Escherichia coli O157:H7 str. Sakai 913958 NP_310630.1 CDS ECs2603 NC_002695.1 2580905 2581333 D ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2580905..2581333 Escherichia coli O157:H7 str. Sakai 915311 NP_310631.1 CDS ECs2604 NC_002695.1 2581340 2582764 R similar to OTSA_ECOLI gi|1788206 (conserved in Escherichia coli K-12); trehalose-6-phosphate synthase complement(2581340..2582764) Escherichia coli O157:H7 str. Sakai 912524 NP_310632.1 CDS ECs2605 NC_002695.1 2582739 2583539 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(2582739..2583539) Escherichia coli O157:H7 str. Sakai 913656 NP_310635.1 CDS araG NC_002695.1 2584707 2586221 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(2584707..2586221) Escherichia coli O157:H7 str. Sakai 913724 NP_310636.1 CDS ECs2609 NC_002695.1 2586291 2587280 R similar to ARAF_ECOLI gi|1788211 (conserved in Escherichia coli K-12); L-arabinose-binding periplasmic protein complement(2586291..2587280) Escherichia coli O157:H7 str. Sakai 912678 NP_310637.1 CDS ECs2610 NC_002695.1 2588077 2588580 D similar to YECI_ECOLI gi|1788212 (conserved in Escherichia coli K-12); ferritin 2588077..2588580 Escherichia coli O157:H7 str. Sakai 913020 NP_944547.1 CDS ECs5464 NC_002695.1 2588660 2588911 R hypothetical protein complement(2588660..2588911) Escherichia coli O157:H7 str. Sakai 2693754 NP_310639.1 CDS ECs2612 NC_002695.1 2589374 2589697 D similar to B1904_ECOLI gi|1788215 (conserved in Escherichia coli K-12); hypothetical protein 2589374..2589697 Escherichia coli O157:H7 str. Sakai 913636 NP_310640.1 CDS ECs2613 NC_002695.1 2589868 2590365 D cytoplasmic iron storage protein; ferritin 2589868..2590365 Escherichia coli O157:H7 str. Sakai 913633 NP_310641.1 CDS ECs2614 NC_002695.1 2590402 2590641 R similar to YECH_ECOLI gi|1788217 (conserved in Escherichia coli K-12); hypothetical protein complement(2590402..2590641) Escherichia coli O157:H7 str. Sakai 913752 NP_310642.1 CDS ECs2615 NC_002695.1 2590833 2592044 D similar to TYRP_ECOLI gi|1788218 (conserved in Escherichia coli K-12); tyrosine-specific transporter 2590833..2592044 Escherichia coli O157:H7 str. Sakai 914224 NP_310643.1 CDS ECs2616 NC_002695.1 2592106 2592771 R similar to YECA_ECOLI gi|1788219 (conserved in Escherichia coli K-12); hypothetical protein complement(2592106..2592771) Escherichia coli O157:H7 str. Sakai 914153 NP_310644.1 CDS ECs2617 NC_002695.1 2593128 2594129 R similar to integrases e.g. [Bacteriophage S2] gi|1679807|emb|CAA96221.1; integrase complement(2593128..2594129) Escherichia coli O157:H7 str. Sakai 914199 NP_310645.1 CDS ECs2618 NC_002695.1 2594135 2594482 R similar to hypothetical protein b1839 [Escherichia coli] gi|7451973|pir||G64945; hypothetical protein complement(2594135..2594482) Escherichia coli O157:H7 str. Sakai 914225 NP_310646.1 CDS ECs2619 NC_002695.1 2594512 2595162 R similar to cell division protein Div [Escherichia coli] gi|2494741|sp|Q11185|YPD5_CAEEL; hypothetical protein complement(2594512..2595162) Escherichia coli O157:H7 str. Sakai 912566 NP_310647.1 CDS ECs2620 NC_002695.1 2595178 2595582 R similar to transcriptional regulators e.g. [Neisseria meningitidis] gi|7226247|gb|AAF41408.1; transcriptional regulator complement(2595178..2595582) Escherichia coli O157:H7 str. Sakai 912489 NP_944548.1 CDS ECs5465 NC_002695.1 2595658 2595864 D hypothetical protein 2595658..2595864 Escherichia coli O157:H7 str. Sakai 2693755 NP_310649.1 CDS ECs2622 NC_002695.1 2595881 2596084 D similar to DNA-binding protein Cox [Vibrio cholerae Bacteriophage K139] gi|4530499|gb|AAD22064.1, phage hypothetical proteins e.g. [Bacteriophage S2] gi|1679810|; DNA-binding protein 2595881..2596084 Escherichia coli O157:H7 str. Sakai 914213 NP_310650.1 CDS ECs2623 NC_002695.1 2596106 2596456 D hypothetical protein 2596106..2596456 Escherichia coli O157:H7 str. Sakai 912604 NP_310651.1 CDS ECs2624 NC_002695.1 2596467 2596745 D hypothetical protein 2596467..2596745 Escherichia coli O157:H7 str. Sakai 912473 NP_310652.1 CDS ECs2625 NC_002695.1 2596757 2596999 D hypothetical protein 2596757..2596999 Escherichia coli O157:H7 str. Sakai 913540 NP_310653.1 CDS ECs2626 NC_002695.1 2597202 2597618 D hypothetical protein 2597202..2597618 Escherichia coli O157:H7 str. Sakai 914065 NP_310654.1 CDS ECs2627 NC_002695.1 2597642 2597845 D hypothetical protein 2597642..2597845 Escherichia coli O157:H7 str. Sakai 914006 NP_310655.1 CDS ECs2628 NC_002695.1 2597842 2598108 D hypothetical protein 2597842..2598108 Escherichia coli O157:H7 str. Sakai 916180 NP_310656.1 CDS ECs2629 NC_002695.1 2598105 2598404 D hypothetical protein 2598105..2598404 Escherichia coli O157:H7 str. Sakai 913897 NP_310658.1 CDS ECs2631 NC_002695.1 2598727 2598957 D similar to derepression protein epsilon [Bacteriophage P4] gi|137833|sp|P05463|VEPS_BPP4; derepression protein 2598727..2598957 Escherichia coli O157:H7 str. Sakai 913749 NP_310659.1 CDS ECs2632 NC_002695.1 2599030 2599395 D hypothetical protein 2599030..2599395 Escherichia coli O157:H7 str. Sakai 914059 NP_310660.1 CDS ECs2633 NC_002695.1 2599540 2602224 D similar to replication proteins e.g. GpA [Bacteriophage 186] gi|1351406|sp|P41064|VPA_BP186; phage replication protein 2599540..2602224 Escherichia coli O157:H7 str. Sakai 914184 NP_310661.1 CDS ECs2634 NC_002695.1 2602301 2603260 D similar to plasmid partition proteins e.g. par [Escherichia coli plasmid R1] gi|134954|sp|P11904|STBA_ECOLI; plasmid partition protein 2602301..2603260 Escherichia coli O157:H7 str. Sakai 914147 NP_310662.1 CDS ECs2635 NC_002695.1 2603265 2603579 D similar to plasmid partition proteins e.g. TSB [Escherichia coli plasmid NR1] gi|134956|sp|P11906|STBB_ECOLI; plasmid partition protein 2603265..2603579 Escherichia coli O157:H7 str. Sakai 914099 NP_310663.1 CDS ECs2636 NC_002695.1 2603599 2604288 R OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase complement(2603599..2604288) Escherichia coli O157:H7 str. Sakai 912558 NP_310664.1 CDS ECs2637 NC_002695.1 2604288 2604614 R OrfA protein of insertion sequence IS629; similar to hypothetical proteins in insertion sequences e.g. [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase complement(2604288..2604614) Escherichia coli O157:H7 str. Sakai 912475 NP_310665.1 CDS ECs2638 NC_002695.1 2605245 2605721 R similar to hypothetical proteins e.g. orf20 [Escherichia coli plasmid pB171] gi|6009396|dbj|BAA84855.1; hypothetical protein complement(2605245..2605721) Escherichia coli O157:H7 str. Sakai 912487 NP_310666.2 CDS ECs2639 NC_002695.1 2605974 2606468 R similar to tail proteins e.g. F protein [Bacteriophage 186] gi|3337273|gb|AAC34171.1; tail protein complement(2605974..2606468) Escherichia coli O157:H7 str. Sakai 914145 NP_310669.1 CDS ECs2642 NC_002695.1 2609265 2609501 R similar to gi|3139111|gb|AAD03292.1; phage tail protein complement(2609265..2609501) Escherichia coli O157:H7 str. Sakai 914093 NP_310670.1 CDS ECs2643 NC_002695.1 2609429 2609794 R similar to tail protein e.g. GpE [Bacteriophage P2] gi|3139110|gb|AAD03291.1; tail protein complement(2609429..2609794) Escherichia coli O157:H7 str. Sakai 912557 NP_310671.1 CDS ECs2644 NC_002695.1 2609849 2610361 R similar to tail tube proteins e.g. tail protein FII [Bacteriophage 186] gi|139325|sp|P22502|VPF2_BPP2; tail tube protein complement(2609849..2610361) Escherichia coli O157:H7 str. Sakai 912318 NP_310672.1 CDS ECs2645 NC_002695.1 2610361 2611545 R similar to tail sheath proteins e.g. FI [Pseudomonas aeruginosa bacteriophage phiCTX] gi|4063795|dbj|BAA36249.1; tail sheath protein complement(2610361..2611545) Escherichia coli O157:H7 str. Sakai 912336 NP_310673.1 CDS ECs2646 NC_002695.1 2611703 2612026 D similar to tail proteins e.g. GpD [Bacteriophage P2] gi|6136287|sp|P10312|VPD_BPP2; tail protein 2611703..2612026 Escherichia coli O157:H7 str. Sakai 914185 NP_310677.1 CDS ECs2650 NC_002695.1 2614540 2615088 R similar to PGSA_ECOLI gi|1788220 (conserved in Escherichia coli K-12); phosphatidylglycerophosphate synthetase complement(2614540..2615088) Escherichia coli O157:H7 str. Sakai 913922 NP_310678.2 CDS uvrC NC_002695.1 2615145 2616977 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(2615145..2616977) Escherichia coli O157:H7 str. Sakai 913874 NP_310679.1 CDS ECs2652 NC_002695.1 2616974 2617630 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(2616974..2617630) Escherichia coli O157:H7 str. Sakai 912605 NP_310680.1 CDS ECs2653 NC_002695.1 2618089 2618313 D similar to YECF_ECOLI gi|1788223 (conserved in Escherichia coli K-12); hypothetical protein 2618089..2618313 Escherichia coli O157:H7 str. Sakai 912374 NP_310681.1 CDS ECs2654 NC_002695.1 2618381 2619103 R regulates genes involved in cell division; SdiA family transcriptional regulator complement(2618381..2619103) Escherichia coli O157:H7 str. Sakai 912965 NP_310682.1 CDS ECs2655 NC_002695.1 2619333 2620085 R similar to YECC_ECOLI gi|1788225 (conserved in Escherichia coli K-12); amino-acid ABC transporter ATP-binding protein complement(2619333..2620085) Escherichia coli O157:H7 str. Sakai 913971 NP_310683.1 CDS ECs2656 NC_002695.1 2620082 2620750 R similar to YECS_ECOLI gi|1788226 (conserved in Escherichia coli K-12); transport system permease complement(2620082..2620750) Escherichia coli O157:H7 str. Sakai 913751 NP_310686.1 CDS ECs2659 NC_002695.1 2621855 2622655 R similar to FLIY_ECOLI gi|1788228 (conserved in Escherichia coli K-12); cystine transporter subunit complement(2621855..2622655) Escherichia coli O157:H7 str. Sakai 914100 NP_310687.1 CDS ECs2660 NC_002695.1 2622743 2623330 R expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ complement(2622743..2623330) Escherichia coli O157:H7 str. Sakai 913820 NP_310688.1 CDS fliA NC_002695.1 2623340 2624059 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor complement(2623340..2624059) Escherichia coli O157:H7 str. Sakai 914052 NP_310689.1 CDS ECs2662 NC_002695.1 2624379 2626136 R structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin complement(2624379..2626136) Escherichia coli O157:H7 str. Sakai 915172 NP_310690.1 CDS fliD NC_002695.1 2626402 2627799 D involved in flagellin assembly; flagellar capping protein 2626402..2627799 Escherichia coli O157:H7 str. Sakai 913755 NP_310691.1 CDS fliS NC_002695.1 2627824 2628234 D flagellin specific chaperone; flagellar protein FliS 2627824..2628234 Escherichia coli O157:H7 str. Sakai 912953 NP_310692.1 CDS ECs2665 NC_002695.1 2628234 2628599 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2628234..2628599 Escherichia coli O157:H7 str. Sakai 912872 NP_310693.1 CDS ECs2666 NC_002695.1 2628677 2630164 D converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2628677..2630164 Escherichia coli O157:H7 str. Sakai 912970 NP_310694.2 CDS ECs2667 NC_002695.1 2630198 2630614 R similar to YEDD_ECOLI gi|1788237 (conserved in Escherichia coli K-12); hypothetical protein complement(2630198..2630614) Escherichia coli O157:H7 str. Sakai 912941 NP_310695.1 CDS ECs2668 NC_002695.1 2630798 2632003 D similar to YEDE_ECOLI gi|1788238 (conserved in Escherichia coli K-12); hypothetical protein 2630798..2632003 Escherichia coli O157:H7 str. Sakai 912742 NP_310696.1 CDS ECs2669 NC_002695.1 2632000 2632233 D similar to YEDF_ECOLI gi|1788239 (conserved in Escherichia coli K-12); hypothetical protein 2632000..2632233 Escherichia coli O157:H7 str. Sakai 913714 NP_310697.1 CDS ECs2670 NC_002695.1 2632342 2633010 D similar to YEDK_ECOLI gi|1788240 (conserved in Escherichia coli K-12); hypothetical protein 2632342..2633010 Escherichia coli O157:H7 str. Sakai 913923 NP_310702.1 CDS ECs2675 NC_002695.1 2636986 2637264 D similar to B1936_ECOLI gi|1788246 (conserved in Escherichia coli K-12); hypothetical protein 2636986..2637264 Escherichia coli O157:H7 str. Sakai 912779 NP_310703.1 CDS fliE NC_002695.1 2637184 2637498 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(2637184..2637498) Escherichia coli O157:H7 str. Sakai 912495 NP_310704.1 CDS fliF NC_002695.1 2637713 2639371 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2637713..2639371 Escherichia coli O157:H7 str. Sakai 912989 NP_310705.1 CDS fliG NC_002695.1 2639364 2640359 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2639364..2640359 Escherichia coli O157:H7 str. Sakai 912982 NP_310706.2 CDS fliH NC_002695.1 2640352 2641038 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2640352..2641038 Escherichia coli O157:H7 str. Sakai 913760 NP_310707.1 CDS fliI NC_002695.1 2641100 2642473 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2641100..2642473 Escherichia coli O157:H7 str. Sakai 912799 NP_310708.1 CDS fliJ NC_002695.1 2642492 2642935 D rod/hook and filament chaperone; flagellar biosynthesis chaperone 2642492..2642935 Escherichia coli O157:H7 str. Sakai 916514 NP_310709.1 CDS ECs2682 NC_002695.1 2642932 2644059 D similar to FLIK_ECOLI gi|1788253 (conserved in Escherichia coli K-12); flagellar hook-length control protein 2642932..2644059 Escherichia coli O157:H7 str. Sakai 913014 NP_310710.1 CDS fliL NC_002695.1 2644164 2644628 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2644164..2644628 Escherichia coli O157:H7 str. Sakai 913120 NP_310711.1 CDS fliM NC_002695.1 2644633 2645637 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2644633..2645637 Escherichia coli O157:H7 str. Sakai 913591 NP_310712.1 CDS fliN NC_002695.1 2645634 2646047 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2645634..2646047 Escherichia coli O157:H7 str. Sakai 913021 NP_310713.2 CDS ECs2686 NC_002695.1 2646050 2646415 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2646050..2646415 Escherichia coli O157:H7 str. Sakai 913050 NP_310714.1 CDS fliP NC_002695.1 2646415 2647152 D FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2646415..2647152 Escherichia coli O157:H7 str. Sakai 913785 NP_310715.1 CDS fliQ NC_002695.1 2647162 2647431 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2647162..2647431 Escherichia coli O157:H7 str. Sakai 914194 NP_310716.1 CDS fliR NC_002695.1 2647439 2648224 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2647439..2648224 Escherichia coli O157:H7 str. Sakai 913551 NP_310717.1 CDS ECs2690 NC_002695.1 2648514 2649137 D similar to RCSA_ECOLI gi|1788262 (conserved in Escherichia coli K-12); transcriptional regulator for ctr capsule biosynthesis 2648514..2649137 Escherichia coli O157:H7 str. Sakai 913009 NP_310718.1 CDS ECs2691 NC_002695.1 2649181 2649369 R similar to DSRB_ECOLI gi|1788263 (conserved in Escherichia coli K-12); hypothetical protein complement(2649181..2649369) Escherichia coli O157:H7 str. Sakai 912856 NP_310719.2 CDS ECs2692 NC_002695.1 2649529 2649759 D similar to B1953_ECOLI gi|1788264 (conserved in Escherichia coli K-12); hypothetical protein 2649529..2649759 Escherichia coli O157:H7 str. Sakai 913583 NP_310720.1 CDS ECs2693 NC_002695.1 2650057 2650872 D catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2650057..2650872 Escherichia coli O157:H7 str. Sakai 913699 NP_310721.1 CDS ECs2694 NC_002695.1 2650869 2652563 R similar to B1956_ECOLI gi|1788266 (conserved in Escherichia coli K-12); hypothetical protein complement(2650869..2652563) Escherichia coli O157:H7 str. Sakai 912776 NP_310722.1 CDS ECs2695 NC_002695.1 2652734 2652916 R similar to B1957_ECOLI gi|1788267 (conserved in Escherichia coli K-12); hypothetical protein complement(2652734..2652916) Escherichia coli O157:H7 str. Sakai 913057 NP_310723.1 CDS ECs2696 NC_002695.1 2652995 2653912 R similar to YEDI_ECOLI gi|1788268 (conserved in Escherichia coli K-12); hypothetical protein complement(2652995..2653912) Escherichia coli O157:H7 str. Sakai 913412 NP_310724.1 CDS ECs2697 NC_002695.1 2654085 2655005 D similar to YEDA_ECOLI gi|1788269 (conserved in Escherichia coli K-12); hypothetical protein 2654085..2655005 Escherichia coli O157:H7 str. Sakai 913482 NP_310725.1 CDS ECs2698 NC_002695.1 2654994 2655464 R similar to VSR_ECOLI gi|1788270 (conserved in Escherichia coli K-12); Vsr; DNA mismatch endonuclease complement(2654994..2655464) Escherichia coli O157:H7 str. Sakai 914207 NP_310726.1 CDS ECs2699 NC_002695.1 2655445 2656863 R similar to DCM_ECOLI gi|1788271 (conserved in Escherichia coli K-12); DNA cytosine methylase complement(2655445..2656863) Escherichia coli O157:H7 str. Sakai 913056 NP_310727.1 CDS ECs2700 NC_002695.1 2656930 2657625 R similar to YEDJ_ECOLI gi|1788273 (conserved in Escherichia coli K-12); hypothetical protein complement(2656930..2657625) Escherichia coli O157:H7 str. Sakai 913053 NP_310728.1 CDS ECs2701 NC_002695.1 2657721 2658047 R similar to B1963_ECOLI gi|1788274 (conserved in Escherichia coli K-12); hypothetical protein complement(2657721..2658047) Escherichia coli O157:H7 str. Sakai 913006 NP_310729.1 CDS ECs2702 NC_002695.1 2658596 2659240 D similar to B1964_ECOLI gi|1788275, B1965_ECOLI gi|1788276, OMPC_ECOLI gi|1788544; outer membrane protein 2658596..2659240 Escherichia coli O157:H7 str. Sakai 913927 NP_310730.1 CDS ECs2703 NC_002695.1 2659207 2659782 D similar to B1965_ECOLI gi|1788276, outer membrane protein B1966_ECOLI gi|1788277; hypothetical protein 2659207..2659782 Escherichia coli O157:H7 str. Sakai 913248 NP_310731.1 CDS ECs2704 NC_002695.1 2659863 2660213 D hypothetical protein 2659863..2660213 Escherichia coli O157:H7 str. Sakai 912443 NP_310732.1 CDS ECs2705 NC_002695.1 2660374 2661225 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2660374..2661225 Escherichia coli O157:H7 str. Sakai 912670 NP_310733.1 CDS ECs2706 NC_002695.1 2661333 2662691 R similar to YEDV_ECOLI gi|1788279 (conserved in Escherichia coli K-12); 2-component sensor protein complement(2661333..2662691) Escherichia coli O157:H7 str. Sakai 913474 NP_310734.2 CDS ECs2707 NC_002695.1 2662691 2663362 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2662691..2663362) Escherichia coli O157:H7 str. Sakai 913174 NP_310735.1 CDS ECs2708 NC_002695.1 2663495 2663908 D similar to B1970_ECOLI gi|1788281 (conserved in Escherichia coli K-12); hypothetical protein 2663495..2663908 Escherichia coli O157:H7 str. Sakai 912669 NP_310736.1 CDS ECs2709 NC_002695.1 2664016 2665020 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2664016..2665020 Escherichia coli O157:H7 str. Sakai 912771 NP_310737.1 CDS ECs2710 NC_002695.1 2665021 2665656 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2665021..2665656 Escherichia coli O157:H7 str. Sakai 914824 NP_310738.1 CDS ECs2711 NC_002695.1 2665913 2666563 D similar to B1973_ECOLI gi|1788284 (conserved in Escherichia coli K-12); hypothetical protein 2665913..2666563 Escherichia coli O157:H7 str. Sakai 912711 NP_310739.1 CDS ECs2712 NC_002695.1 2666876 2667436 D similar to YODB_ECOLI gi|1788286 (conserved in Escherichia coli K-12); cytochrome 2666876..2667436 Escherichia coli O157:H7 str. Sakai 912539 NP_310740.1 CDS ECs2713 NC_002695.1 2667460 2667702 D hypothetical protein 2667460..2667702 Escherichia coli O157:H7 str. Sakai 912515 NP_310741.1 CDS ECs2714 NC_002695.1 2668573 2669226 D hypothetical protein 2668573..2669226 Escherichia coli O157:H7 str. Sakai 912496 NP_310742.1 CDS ECs2715 NC_002695.1 2669551 2670564 D secerted effector protein; similar to hypothetical proteins e.g. EspF [Escherichia coli strain B10] gi|6090818|gb|AAF03351.1|AF116900_2 ESPF_ECOLI; EspF-like protein 2669551..2670564 Escherichia coli O157:H7 str. Sakai 912330 NP_310743.1 CDS ECs2716 NC_002695.1 2670690 2670959 R similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein complement(2670690..2670959) Escherichia coli O157:H7 str. Sakai 912477 NP_310744.1 CDS ECs2717 NC_002695.1 2670961 2672274 R similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein complement(2670961..2672274) Escherichia coli O157:H7 str. Sakai 912550 NP_310745.1 CDS ECs2718 NC_002695.1 2672339 2672938 R similar to Lom outer membrane protein precursors e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein complement(2672339..2672938) Escherichia coli O157:H7 str. Sakai 913421 NP_310748.1 CDS ECs2721 NC_002695.1 2676725 2677402 R similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein complement(2676725..2677402) Escherichia coli O157:H7 str. Sakai 913300 NP_310749.1 CDS ECs2722 NC_002695.1 2677300 2677869 R similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein complement(2677300..2677869) Escherichia coli O157:H7 str. Sakai 914149 NP_310750.1 CDS ECs2723 NC_002695.1 2678054 2678752 R similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein complement(2678054..2678752) Escherichia coli O157:H7 str. Sakai 912305 NP_310751.1 CDS ECs2724 NC_002695.1 2678752 2679081 R similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein complement(2678752..2679081) Escherichia coli O157:H7 str. Sakai 913283 NP_310754.1 CDS ECs2727 NC_002695.1 2681637 2681942 R bacteriophage tail component; similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein complement(2681637..2681942) Escherichia coli O157:H7 str. Sakai 912621 NP_310755.1 CDS ECs2728 NC_002695.1 2682077 2682508 R bacteriophage tail component; similar to minor tail proteins e.g. GpG [Bacteriophage lambda]gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein complement(2682077..2682508) Escherichia coli O157:H7 str. Sakai 912612 NP_310756.2 CDS ECs2729 NC_002695.1 2682522 2683184 R hypothetical protein complement(2682522..2683184) Escherichia coli O157:H7 str. Sakai 912893 NP_310757.1 CDS ECs2730 NC_002695.1 2683244 2683510 R bacteriophage head component; may be truncated; similar to major head proteins e.g. Gp7 [Bacteriophage 21] gi|547612|sp|P36270|HEAD_BPP21, gi|547612|sp|P36270; major head protein complement(2683244..2683510) Escherichia coli O157:H7 str. Sakai 912485 NP_310758.1 CDS ECs2731 NC_002695.1 2683568 2683915 R bacteriophage head component; similar to head decoration proteins e.g. Gpshp [Bacteriophage 21] gi|549437|sp|P36275|VSHP_BPP21; head decoration protein complement(2683568..2683915) Escherichia coli O157:H7 str. Sakai 912658 NP_310759.1 CDS ECs2732 NC_002695.1 2683952 2685457 R similar to minor head proteins e.g. head-tail preconnector Gp5 [Bacteriophage 21] gi|549296|sp|P36273|VG05_BPP21; contains scaffold protein; head-tail preconnector protein complement(2683952..2685457) Escherichia coli O157:H7 str. Sakai 913443 NP_310760.1 CDS ECs2733 NC_002695.1 2685447 2687039 R similar to portal proteins e.g. Gp5 [Bacteriophage 21] gi|549295|sp|P36272|VG04_BPP21; portal protein complement(2685447..2687039) Escherichia coli O157:H7 str. Sakai 915258 NP_310761.1 CDS ECs2734 NC_002695.1 2687036 2687242 R similar to phage proteins e.g. head completion protein Gp3 [Bacteriophage 21] gi|549294|sp|P36271|VG03_BPP21; head completion protein complement(2687036..2687242) Escherichia coli O157:H7 str. Sakai 913168 NP_310762.1 CDS ECs2735 NC_002695.1 2687226 2689154 R similar to terminase large subunits e.g. Gp2 [Bacteriophage 21] gi|2851579|sp|P36693|TERL_BPP21; terminase large subunit complement(2687226..2689154) Escherichia coli O157:H7 str. Sakai 912708 NP_310763.1 CDS ECs2736 NC_002695.1 2689126 2689635 R similar to terminase small subunits e.g. Gp1 [Bacteriophage N15] gi|7444578|pir||T13087; terminase small subunit complement(2689126..2689635) Escherichia coli O157:H7 str. Sakai 914026 NP_310764.1 CDS ECs2737 NC_002695.1 2690336 2690650 R similar to PerC (BfpW) [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional regulator complement(2690336..2690650) Escherichia coli O157:H7 str. Sakai 916099 NP_944549.1 CDS ECs5470 NC_002695.1 2690892 2691032 R hypothetical protein complement(2690892..2691032) Escherichia coli O157:H7 str. Sakai 2693832 NP_310765.1 CDS ECs2739 NC_002695.1 2691115 2691582 R host cell lysis; similar to Rz endopeptidases e.g. [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1|; endopeptidase complement(2691115..2691582) Escherichia coli O157:H7 str. Sakai 912834 NP_310767.1 CDS ECs2740 NC_002695.1 2691734 2691916 R hypothetical protein complement(2691734..2691916) Escherichia coli O157:H7 str. Sakai 912980 NP_310768.1 CDS ECs2741 NC_002695.1 2692072 2692605 R similar to s e.g. R protein [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1|; endolysin complement(2692072..2692605) Escherichia coli O157:H7 str. Sakai 915021 NP_310769.1 CDS ECs2742 NC_002695.1 2692656 2693000 R similar to YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein complement(2692656..2693000) Escherichia coli O157:H7 str. Sakai 914063 NP_310770.1 CDS ECs2743 NC_002695.1 2693005 2693211 R host cell lysis; similar to holins e.g. protein S [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1|; holin complement(2693005..2693211) Escherichia coli O157:H7 str. Sakai 912472 NP_310771.1 CDS ECs2744 NC_002695.1 2693531 2693857 D OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 2693531..2693857 Escherichia coli O157:H7 str. Sakai 914168 NP_310772.1 CDS ECs2745 NC_002695.1 2693854 2694744 D OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 2693854..2694744 Escherichia coli O157:H7 str. Sakai 913374 NP_310773.1 CDS ECs2746 NC_002695.1 2694826 2696676 R similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein complement(2694826..2696676) Escherichia coli O157:H7 str. Sakai 916570 NP_310775.1 CDS ECs2748 NC_002695.1 2696990 2697157 R hypothetical protein complement(2696990..2697157) Escherichia coli O157:H7 str. Sakai 914183 NP_310776.1 CDS ECs2749 NC_002695.1 2697154 2697582 R similar to TerB proteins e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein complement(2697154..2697582) Escherichia coli O157:H7 str. Sakai 914021 NP_310777.1 CDS ECs2750 NC_002695.1 2698216 2698905 R similar to antiterminators e.g. protein Q [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; antiterminator complement(2698216..2698905) Escherichia coli O157:H7 str. Sakai 913869 NP_310778.1 CDS ECs2751 NC_002695.1 2698902 2699261 R similar to Rus protein e.g. [Bacteriophage 82] gi|6901639|gb|AAF31142.1| GP67_BPHK97, Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1|; crossover junction endodeoxyribonuclease complement(2698902..2699261) Escherichia coli O157:H7 str. Sakai 914321 NP_310779.1 CDS ECs2752 NC_002695.1 2699274 2700323 R similar to hypothetical proteins e.g. b1560 [Escherichia coli] gi|7466196|pir||C64911; hypothetical protein complement(2699274..2700323) Escherichia coli O157:H7 str. Sakai 913345 NP_310780.1 CDS ECs2753 NC_002695.1 2700325 2700603 R similar to orf QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1|; hypothetical protein complement(2700325..2700603) Escherichia coli O157:H7 str. Sakai 912507 NP_310781.1 CDS ECs2754 NC_002695.1 2700771 2700983 R similar to Hok/Gef family e.g. MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76; prophage maintenance protein complement(2700771..2700983) Escherichia coli O157:H7 str. Sakai 912381 NP_310782.1 CDS ECs2755 NC_002695.1 2701170 2701274 R hypothetical protein complement(2701170..2701274) Escherichia coli O157:H7 str. Sakai 912367 NP_310783.1 CDS ECs2756 NC_002695.1 2701384 2701947 R similar to GP45 Bacteriophage N15 T13131, Escherichia coli H65009; hypothetical protein complement(2701384..2701947) Escherichia coli O157:H7 str. Sakai 914311 NP_310784.1 CDS ECs2757 NC_002695.1 2702074 2702385 R hypothetical protein complement(2702074..2702385) Escherichia coli O157:H7 str. Sakai 913017 NP_310785.1 CDS ECs2758 NC_002695.1 2702382 2702570 R hypothetical protein complement(2702382..2702570) Escherichia coli O157:H7 str. Sakai 912315 NP_310786.1 CDS ECs2759 NC_002695.1 2702567 2702923 R hypothetical protein complement(2702567..2702923) Escherichia coli O157:H7 str. Sakai 914801 NP_310787.1 CDS ECs2760 NC_002695.1 2702920 2703144 R hypothetical protein complement(2702920..2703144) Escherichia coli O157:H7 str. Sakai 913965 NP_310788.1 CDS ECs2761 NC_002695.1 2703166 2703864 R similar to YdaW [Escherichia coli] gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein complement(2703166..2703864) Escherichia coli O157:H7 str. Sakai 913776 NP_310789.1 CDS ECs2762 NC_002695.1 2703899 2704561 R similar to replication proteins e.g. Gp14 [Bacteriophage phi-80] gi|137937|sp|P14814|VG14_BPPH8; phage replication protein complement(2703899..2704561) Escherichia coli O157:H7 str. Sakai 913274 NP_310790.1 CDS ECs2763 NC_002695.1 2704353 2705390 R similar to replication termination factor dnaT (primosomal protein I) [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein complement(2704353..2705390) Escherichia coli O157:H7 str. Sakai 913970 NP_310791.1 CDS ECs2764 NC_002695.1 2705459 2705884 R similar to YdaT [Escherichia coli] gi|3025103|sp|P76064|YDAT_ECOLI, regulatory protein CII [Bacteriophage phi-80] gi|133360|sp|P14820|RPC2_BPPH8; hypothetical protein complement(2705459..2705884) Escherichia coli O157:H7 str. Sakai 914158 NP_310792.1 CDS ECs2765 NC_002695.1 2705881 2706108 R repressor; similar to DicC (repressor protein of division inhibition gene dicB) [Escherichia coli] gi|118633|sp|P06965|DICC_ECOLI; cell division control protein complement(2705881..2706108) Escherichia coli O157:H7 str. Sakai 912335 NP_310793.1 CDS ECs2766 NC_002695.1 2706203 2706850 D similar to repressor proteins e.g. C2 repressor [Bacteriophage P22] gi|133359|sp|P03035|RPC2_BPP22; repressor protein 2706203..2706850 Escherichia coli O157:H7 str. Sakai 913129 NP_310794.1 CDS ECs2767 NC_002695.1 2707125 2707277 D hypothetical protein 2707125..2707277 Escherichia coli O157:H7 str. Sakai 912468 NP_310795.1 CDS ECs2768 NC_002695.1 2707758 2707946 D similar to DicB protein [Escherichia coli] gi|2507009|sp|P09557|DICB_ECOLI; cell division inhibition protein 2707758..2707946 Escherichia coli O157:H7 str. Sakai 912649 NP_310796.1 CDS ECs2769 NC_002695.1 2707943 2708131 D similar to hypothetical proteins e.g. YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein 2707943..2708131 Escherichia coli O157:H7 str. Sakai 912292 NP_310797.1 CDS ECs2770 NC_002695.1 2708227 2710425 D hypothetical protein 2708227..2710425 Escherichia coli O157:H7 str. Sakai 913606 NP_310798.1 CDS ECs2771 NC_002695.1 2710379 2710699 D hypothetical protein 2710379..2710699 Escherichia coli O157:H7 str. Sakai 912462 NP_310799.1 CDS ECs2772 NC_002695.1 2710758 2710961 D hypothetical protein 2710758..2710961 Escherichia coli O157:H7 str. Sakai 912334 NP_310800.1 CDS ECs2773 NC_002695.1 2710961 2711983 D similar to integrases e.g. [Bacteriophage HK022] gi|138560|sp|P16407|VINT_BPHK0; integrase 2710961..2711983 Escherichia coli O157:H7 str. Sakai 913562 NP_310801.2 CDS ECs2774 NC_002695.1 2712219 2713016 D similar to B1976_ECOLI gi|1788287 (conserved in Escherichia coli K-12); hypothetical protein 2712219..2713016 Escherichia coli O157:H7 str. Sakai 914176 NP_310802.1 CDS ECs2775 NC_002695.1 2713479 2717486 D similar to B1978_ECOLI gi|1788288; may contain frameshift; hypothetical protein 2713479..2717486 Escherichia coli O157:H7 str. Sakai 914032 NP_310803.1 CDS ECs2776 NC_002695.1 2717452 2721489 D similar to B1978_ECOLI gi|1788288; may contain frameshift; hypothetical protein 2717452..2721489 Escherichia coli O157:H7 str. Sakai 912369 NP_310804.1 CDS ECs2777 NC_002695.1 2721751 2722803 R similar to B1980_ECOLI gi|1788291, B1979_ECOLI gi|1788290; hypothetical protein complement(2721751..2722803) Escherichia coli O157:H7 str. Sakai 912960 NP_310805.1 CDS ECs2778 NC_002695.1 2723117 2724433 D similar to SHIA_ECOLI gi|1788292 (conserved in Escherichia coli K-12); shikimate transporter 2723117..2724433 Escherichia coli O157:H7 str. Sakai 912841 NP_310806.1 CDS ECs2779 NC_002695.1 2724535 2725989 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2724535..2725989 Escherichia coli O157:H7 str. Sakai 912716 NP_310807.1 CDS ECs2780 NC_002695.1 2726332 2727048 D similar to B1983_ECOLI gi|1788294 (conserved in Escherichia coli K-12); hypothetical protein 2726332..2727048 Escherichia coli O157:H7 str. Sakai 912408 NP_310810.1 CDS cbl NC_002695.1 2729435 2730385 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2729435..2730385) Escherichia coli O157:H7 str. Sakai 912516 NP_310811.1 CDS ECs2784 NC_002695.1 2730487 2731404 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2730487..2731404) Escherichia coli O157:H7 str. Sakai 912304 NP_310812.1 CDS ECs2785 NC_002695.1 2731861 2732793 R similar to ERFK_ECOLI gi|1788299 (conserved in Escherichia coli K-12); hypothetical protein complement(2731861..2732793) Escherichia coli O157:H7 str. Sakai 912693 NP_310813.1 CDS cobT NC_002695.1 2732858 2733937 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2732858..2733937) Escherichia coli O157:H7 str. Sakai 913061 NP_310814.1 CDS cobS NC_002695.1 2733949 2734692 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2733949..2734692) Escherichia coli O157:H7 str. Sakai 913691 NP_310815.1 CDS cobU NC_002695.1 2734689 2735234 R catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase complement(2734689..2735234) Escherichia coli O157:H7 str. Sakai 912633 NP_310816.1 CDS ECs2789 NC_002695.1 2735575 2735976 D similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1|; hypothetical protein 2735575..2735976 Escherichia coli O157:H7 str. Sakai 913111 NP_310817.1 CDS ECs2790 NC_002695.1 2735973 2736320 D similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1|; hypothetical protein 2735973..2736320 Escherichia coli O157:H7 str. Sakai 914247 NP_310818.1 CDS ECs2791 NC_002695.1 2736370 2737908 D similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 2736370..2737908 Escherichia coli O157:H7 str. Sakai 913038 NP_310819.1 CDS ECs2792 NC_002695.1 2739356 2741503 D similar to B1995_ECOLI gi|1788304; hypothetical protein 2739356..2741503 Escherichia coli O157:H7 str. Sakai 912399 NP_310821.1 CDS ECs2794 NC_002695.1 2741875 2742201 D OrfA protein of insertion sequence IS629; similar to IS629 hypothetical proteins e.g. [Escherichia coli plasmid pO157] gi|7444868|pir||T00241; transposase 2741875..2742201 Escherichia coli O157:H7 str. Sakai 912676 NP_310822.1 CDS ECs2795 NC_002695.1 2742198 2743088 D OrfB protein of insertion sequence IS629; similar to IS629 transposase [Escherichia coli plasmid pO157) gi|7443862|pir||T00240; transposase 2742198..2743088 Escherichia coli O157:H7 str. Sakai 913362 NP_310823.1 CDS ECs2796 NC_002695.1 2743072 2743953 D similar to hypothetical proteins e.g. YjdA [Escherichia coli] gi|731985|sp|P16694|YJDA_ECOLI; hypothetical protein 2743072..2743953 Escherichia coli O157:H7 str. Sakai 913043 NP_310824.1 CDS ECs2797 NC_002695.1 2743950 2744855 D similar to hypothetical protein YjcZ [Escherichia coli] gi|731984|sp|P39267|YJCZ_ECOLI; hypothetical protein 2743950..2744855 Escherichia coli O157:H7 str. Sakai 913052 NP_310825.1 CDS ECs2798 NC_002695.1 2744852 2745922 D similar to hypothetical protein [Xanthomonas campestris] gi|6689533|emb|CAB65709.1|; hypothetical protein 2744852..2745922 Escherichia coli O157:H7 str. Sakai 912905 NP_310826.1 CDS ECs2799 NC_002695.1 2746058 2746741 D hypothetical protein 2746058..2746741 Escherichia coli O157:H7 str. Sakai 912654 NP_310827.1 CDS ECs2800 NC_002695.1 2746757 2747167 D hypothetical protein 2746757..2747167 Escherichia coli O157:H7 str. Sakai 913073 NP_310828.1 CDS ECs2801 NC_002695.1 2747388 2748209 D similar to hypothetical proteins e.g. YafZ [Escherichia coli] gi|2495487|sp|P77206|YAFZ_ECOLI; hypothetical protein 2747388..2748209 Escherichia coli O157:H7 str. Sakai 913032 NP_310829.1 CDS ECs2802 NC_002695.1 2748291 2748770 D similar to hypothetical proteins e.g. YfjX [Escherichia coli] gi|1723636|sp|P52139|YFJX_ECOLI, antirestriction proteins e.g. KlcA protein [plasmid RK2] gi|1730051|sp|P52603; antirestriction protein 2748291..2748770 Escherichia coli O157:H7 str. Sakai 912574 NP_310830.1 CDS ECs2803 NC_002695.1 2748785 2749261 D similar to RADC family DNA repair protein YEES_ECOLI gi|1788312 (conserved in Escherichia coli K-12); DNA repair protein 2748785..2749261 Escherichia coli O157:H7 str. Sakai 914222 NP_310831.1 CDS ECs2804 NC_002695.1 2749324 2749545 D similar to YEET_ECOLI gi|1788313 (conserved in Escherichia coli K-12); hypothetical protein 2749324..2749545 Escherichia coli O157:H7 str. Sakai 912759 NP_310832.1 CDS ECs2805 NC_002695.1 2749619 2749987 D similar to YEEU_ECOLI gi|1788314 (conserved in Escherichia coli K-12); structural protein 2749619..2749987 Escherichia coli O157:H7 str. Sakai 912732 NP_310833.1 CDS ECs2806 NC_002695.1 2750076 2750339 D similar to YEEV_ECOLI gi|1788315; hypothetical protein 2750076..2750339 Escherichia coli O157:H7 str. Sakai 912310 NP_310834.1 CDS ECs2807 NC_002695.1 2750449 2750640 D similar to YEEW_ECOLI gi|1788316 (conserved in Escherichia coli K-12); hypothetical protein 2750449..2750640 Escherichia coli O157:H7 str. Sakai 913930 NP_310835.1 CDS ECs2808 NC_002695.1 2751081 2751437 D similar to PduV [Salmonella enterica serovar Typhimurium] gb|AAD39020.1; hypothetical protein 2751081..2751437 Escherichia coli O157:H7 str. Sakai 912630 NP_310836.2 CDS ECs2809 NC_002695.1 2751538 2751867 R similar to YEEX_ECOLI gi|1788317 (conserved in Escherichia coli K-12); hypothetical protein complement(2751538..2751867) Escherichia coli O157:H7 str. Sakai 912397 NP_310837.1 CDS ECs2810 NC_002695.1 2752039 2753097 R similar to YEEA_ECOLI gi|1788318 (conserved in Escherichia coli K-12); hypothetical protein complement(2752039..2753097) Escherichia coli O157:H7 str. Sakai 912666 NP_310838.1 CDS ECs2811 NC_002695.1 2753296 2753769 R similar to SBMC_ECOLI gi|1788319 (conserved in Escherichia coli K-12); DNA gyrase inhibitor complement(2753296..2753769) Escherichia coli O157:H7 str. Sakai 914233 NP_310839.1 CDS dacD NC_002695.1 2753888 2755060 R removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase complement(2753888..2755060) Escherichia coli O157:H7 str. Sakai 912747 NP_310840.1 CDS sbcB NC_002695.1 2755263 2756690 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2755263..2756690 Escherichia coli O157:H7 str. Sakai 913411 NP_310841.1 CDS ECs2814 NC_002695.1 2756733 2756960 R similar YEED_ECOLI to gi|1788322 (conserved in Escherichia coli K-12); hypothetical protein complement(2756733..2756960) Escherichia coli O157:H7 str. Sakai 913310 NP_310842.1 CDS ECs2815 NC_002695.1 2756974 2758032 R similar to YEEE_ECOLI gi|1788323 (conserved in Escherichia coli K-12); transport system permease complement(2756974..2758032) Escherichia coli O157:H7 str. Sakai 913376 NP_310843.1 CDS ECs2816 NC_002695.1 2758211 2759575 R similar to YEEF_ECOLI gi|1788325 (conserved in Escherichia coli K-12); amino acid/amine transport protein complement(2758211..2759575) Escherichia coli O157:H7 str. Sakai 912852 NP_310844.2 CDS ECs2817 NC_002695.1 2759836 2760765 R similar to YEEY_ECOLI gi|1788326 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(2759836..2760765) Escherichia coli O157:H7 str. Sakai 912696 NP_310845.1 CDS ECs2818 NC_002695.1 2760811 2761635 R similar to B2016_ECOLI gi|1788327 (conserved in Escherichia coli K-12); hypothetical protein complement(2760811..2761635) Escherichia coli O157:H7 str. Sakai 914191 NP_310847.1 CDS hisG NC_002695.1 2762257 2763156 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2762257..2763156 Escherichia coli O157:H7 str. Sakai 912832 NP_310848.1 CDS hisD NC_002695.1 2763162 2764466 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2763162..2764466 Escherichia coli O157:H7 str. Sakai 912702 NP_310849.1 CDS ECs2822 NC_002695.1 2764463 2765533 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2764463..2765533 Escherichia coli O157:H7 str. Sakai 914123 NP_310850.2 CDS ECs2823 NC_002695.1 2765533 2766600 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2765533..2766600 Escherichia coli O157:H7 str. Sakai 914091 NP_310851.1 CDS hisH NC_002695.1 2766600 2767190 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2766600..2767190 Escherichia coli O157:H7 str. Sakai 913853 NP_310852.2 CDS ECs2825 NC_002695.1 2767190 2767927 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2767190..2767927 Escherichia coli O157:H7 str. Sakai 912886 NP_310853.1 CDS ECs2826 NC_002695.1 2767909 2768685 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2767909..2768685 Escherichia coli O157:H7 str. Sakai 914652 NP_310854.1 CDS ECs2827 NC_002695.1 2768679 2769290 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2768679..2769290 Escherichia coli O157:H7 str. Sakai 912426 NP_310855.2 CDS ECs2828 NC_002695.1 2769387 2770367 R similar to WZZB_ECOLI gi|1788339 (conserved in Escherichia coli K-12); regulator of length of O-antigen component of lipopolysaccharide chains complement(2769387..2770367) Escherichia coli O157:H7 str. Sakai 912641 NP_310856.1 CDS ECs2829 NC_002695.1 2770510 2771676 R similar to UGD_ECOLI gi|1788340 (conserved in Escherichia coli K-12); UDP-glucose 6-dehydrogenase complement(2770510..2771676) Escherichia coli O157:H7 str. Sakai 913058 NP_310857.1 CDS ECs2830 NC_002695.1 2771925 2773331 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2771925..2773331) Escherichia coli O157:H7 str. Sakai 912309 NP_310858.1 CDS ECs2831 NC_002695.1 2773532 2774197 R similar to WbdR [Escherichia coli O157:H7 C664-1992] gi|3435182|gb|AAC32350.1|; acetyltransferase complement(2773532..2774197) Escherichia coli O157:H7 str. Sakai 912352 NP_310860.1 CDS ECs2833 NC_002695.1 2774427 2774591 R similar to H repeat-associated proteins e.g. [Escherichia coli] gi|140772|sp|P28912|YHHI_ECOLI; H repeat-containing protein complement(2774427..2774591) Escherichia coli O157:H7 str. Sakai 913674 NP_310862.1 CDS ECs2835 NC_002695.1 2775460 2776830 R similar to ManB [Escherichia coli O157:H7 C664-1992] gi|3435181|gb|AAC32349.1|; phosphomannomutase complement(2775460..2776830) Escherichia coli O157:H7 str. Sakai 913941 NP_310863.1 CDS ECs2836 NC_002695.1 2776834 2778282 R similar to ManC [Escherichia coli O157:H7 C664-1992] gi|3435180|gb|AAC32348.1|; mannose-1-phosphate guanylyltransferase complement(2776834..2778282) Escherichia coli O157:H7 str. Sakai 912820 NP_310864.1 CDS ECs2837 NC_002695.1 2778264 2778773 R similar to WbdQ [Escherichia coli O157:H7 C664-1992] gi|3435179|gb|AAC32347.1|; GDP-L-fucose pathway enzyme complement(2778264..2778773) Escherichia coli O157:H7 str. Sakai 912421 NP_310865.1 CDS ECs2838 NC_002695.1 2778776 2779741 R similar to Fcl [Escherichia coli O157:H7 C664-1992] gi|4867922|dbj|BAA77731.1|; fucose synthetase complement(2778776..2779741) Escherichia coli O157:H7 str. Sakai 912293 NP_310866.1 CDS ECs2839 NC_002695.1 2779744 2780862 R similar to Gmd [Escherichia coli O157:H7 C664-1992]gi|3435177|gb|AAC32345.1|; GDP-D-mannose dehydratase complement(2779744..2780862) Escherichia coli O157:H7 str. Sakai 912548 NP_944550.1 CDS ECs5479 NC_002695.1 2780370 2780600 D hypothetical protein 2780370..2780600 Escherichia coli O157:H7 str. Sakai 2693774 NP_310867.1 CDS ECs2840 NC_002695.1 2780882 2782096 R similar to WbdP [Escherichia coli O157:H7 C664-1992] gi|3435176|gb|AAC32344.1|; glycosyl transferase family protein complement(2780882..2782096) Escherichia coli O157:H7 str. Sakai 916916 NP_310868.1 CDS ECs2841 NC_002695.1 2782121 2783221 R similar to Per [Escherichia coli O157:H7 C664-1992] gi|3435175|gb|AAC32343.1|; perosamine synthetase complement(2782121..2783221) Escherichia coli O157:H7 str. Sakai 912508 NP_310869.1 CDS ECs2842 NC_002695.1 2783218 2784603 R similar to Wzx [Escherichia coli O157:H7 C664-1992] gi|3435174|gb|AAC32342.1|; O antigen flippase complement(2783218..2784603) Escherichia coli O157:H7 str. Sakai 912601 NP_310870.1 CDS ECs2843 NC_002695.1 2784596 2785342 R similar to WbdO [Escherichia coli O157:H7 C664-1992] gi|3435173|gb|AAC32341.1|; glycosyl transferase family protein complement(2784596..2785342) Escherichia coli O157:H7 str. Sakai 912341 NP_310871.1 CDS ECs2844 NC_002695.1 2785311 2786495 R similar to Wzy [Escherichia coli O157:H7 C664-1992] gi|3435172|gb|AAC32340.1|; O antigen polymerase complement(2785311..2786495) Escherichia coli O157:H7 str. Sakai 912486 NP_310872.1 CDS ECs2845 NC_002695.1 2786492 2787274 R similar to WbdN [Escherichia coli O157:H7 C664-1992] gi|4867915|dbj|BAA77724.1|; glycosyl transferase family protein complement(2786492..2787274) Escherichia coli O157:H7 str. Sakai 912412 NP_310873.1 CDS ECs2846 NC_002695.1 2787593 2788486 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase complement(2787593..2788486) Escherichia coli O157:H7 str. Sakai 914113 NP_310874.1 CDS ECs2847 NC_002695.1 2788729 2789724 R similar to probable UDP-galactose 4-epimerase [Vibrio cholerae] gi|3724321|dbj|BAA33610.1; UDP-galactose 4-epimerase complement(2788729..2789724) Escherichia coli O157:H7 str. Sakai 912320 NP_310875.1 CDS wcaM NC_002695.1 2789882 2791276 R WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein complement(2789882..2791276) Escherichia coli O157:H7 str. Sakai 912592 NP_310876.1 CDS ECs2849 NC_002695.1 2791287 2792507 R similar to WCAL_ECOLI gi|1788357 (conserved in Escherichia coli K-12); colanic acid biosynthesis glycosyl transferase complement(2791287..2792507) Escherichia coli O157:H7 str. Sakai 913350 NP_310877.1 CDS ECs2850 NC_002695.1 2792504 2793784 R similar to WCAK_ECOLI gi|1788358 (conserved in Escherichia coli K-12); pyruvyl transferase complement(2792504..2793784) Escherichia coli O157:H7 str. Sakai 912518 NP_310878.1 CDS ECs2851 NC_002695.1 2793964 2795442 R similar to WZXC_ECOLI gi|1788359 (conserved in Escherichia coli K-12); colanic acid exporter complement(2793964..2795442) Escherichia coli O157:H7 str. Sakai 913065 NP_310879.1 CDS ECs2852 NC_002695.1 2795444 2796838 R WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase complement(2795444..2796838) Escherichia coli O157:H7 str. Sakai 912607 NP_310880.1 CDS ECs2853 NC_002695.1 2796893 2798263 R similar to CPSG_ECOLI gi|1788361 (conserved in Escherichia coli K-12); phosphomannomutase complement(2796893..2798263) Escherichia coli O157:H7 str. Sakai 912432 NP_310881.1 CDS ECs2854 NC_002695.1 2798456 2799892 R similar to CPSB_ECOLI gi|1788362 (conserved in Escherichia coli K-12); mannose-1-phosphate guanylyltransferase complement(2798456..2799892) Escherichia coli O157:H7 str. Sakai 912555 NP_310882.1 CDS ECs2855 NC_002695.1 2799895 2801118 R similar to WCAI_ECOLI gi|1788363 (conserved in Escherichia coli K-12); glycosyl transferase family protein complement(2799895..2801118) Escherichia coli O157:H7 str. Sakai 913677 NP_310883.1 CDS ECs2856 NC_002695.1 2801115 2801597 R similar to WCAH_ECOLI gi|1788364 (conserved in Escherichia coli K-12); GDP-mannose mannosyl hydrolase complement(2801115..2801597) Escherichia coli O157:H7 str. Sakai 913694 NP_310884.1 CDS ECs2857 NC_002695.1 2801597 2802562 R similar to WCAG_ECOLI pdb|1GFS_A (conserved in Escherichia coli K-12); GDP-fucose synthetase chain A complement(2801597..2802562) Escherichia coli O157:H7 str. Sakai 912562 NP_310885.1 CDS ECs2858 NC_002695.1 2802565 2803686 R similar to GMD_ECOLI gi|1788366 (conserved in Escherichia coli K-12); GDP-D-mannose dehydratase complement(2802565..2803686) Escherichia coli O157:H7 str. Sakai 913961 NP_310886.1 CDS ECs2859 NC_002695.1 2803715 2804263 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF complement(2803715..2804263) Escherichia coli O157:H7 str. Sakai 912770 NP_310887.1 CDS ECs2860 NC_002695.1 2804279 2805025 R similar to WCAE_ECOLI gi|1788368 (conserved in Escherichia coli K-12); glycosyl transferase family protein complement(2804279..2805025) Escherichia coli O157:H7 str. Sakai 912985 NP_310888.1 CDS wcaD NC_002695.1 2805036 2806253 R essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein complement(2805036..2806253) Escherichia coli O157:H7 str. Sakai 914908 NP_310889.1 CDS ECs2862 NC_002695.1 2806228 2807445 R similar to WCAC_ECOLI gi|1788370 (conserved in Escherichia coli K-12); glycosyl transferase family protein complement(2806228..2807445) Escherichia coli O157:H7 str. Sakai 912422 NP_310890.1 CDS ECs2863 NC_002695.1 2807442 2807930 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB complement(2807442..2807930) Escherichia coli O157:H7 str. Sakai 912644 NP_310891.1 CDS ECs2864 NC_002695.1 2807933 2808772 R similar to WCAA_ECOLI gi|1788372 (conserved in Escherichia coli K-12); glycosyl transferase family protein complement(2807933..2808772) Escherichia coli O157:H7 str. Sakai 912351 NP_310892.2 CDS ECs2865 NC_002695.1 2808865 2811027 R Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase complement(2808865..2811027) Escherichia coli O157:H7 str. Sakai 912525 NP_310893.1 CDS ECs2866 NC_002695.1 2811030 2811473 R Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase complement(2811030..2811473) Escherichia coli O157:H7 str. Sakai 913690 NP_310894.1 CDS ECs2867 NC_002695.1 2811479 2812618 R similar to WZA_ECOLI gi|1788376 (conserved in Escherichia coli K-12); polysaccharide export protein complement(2811479..2812618) Escherichia coli O157:H7 str. Sakai 913884 NP_310895.2 CDS ECs2868 NC_002695.1 2813277 2814860 D similar to YEGH_ECOLI gi|1788377 (conserved in Escherichia coli K-12); transporter 2813277..2814860 Escherichia coli O157:H7 str. Sakai 914134 NP_310896.1 CDS ECs2869 NC_002695.1 2814935 2815273 D similar to hypothetical proteins e.g. gi|9106618|gb|AAF84382.1|AE003986_12 [Xylella fastidiosa]; hypothetical protein 2814935..2815273 Escherichia coli O157:H7 str. Sakai 912316 NP_310897.1 CDS ECs2870 NC_002695.1 2815263 2815553 D similar to hypothetical protein [Xylella fastidiosa] gb|AAF84486.1|AE003993_5; hypothetical protein 2815263..2815553 Escherichia coli O157:H7 str. Sakai 912763 NP_310898.1 CDS ECs2871 NC_002695.1 2815606 2817459 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein complement(2815606..2817459) Escherichia coli O157:H7 str. Sakai 916574 NP_310899.1 CDS dcd NC_002695.1 2817481 2818062 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2817481..2818062) Escherichia coli O157:H7 str. Sakai 916917 NP_310900.2 CDS ECs2873 NC_002695.1 2818154 2818795 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2818154..2818795) Escherichia coli O157:H7 str. Sakai 916575 NP_310904.1 CDS ECs2877 NC_002695.1 2822533 2823381 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase complement(2822533..2823381) Escherichia coli O157:H7 str. Sakai 916579 NP_310905.2 CDS ECs2878 NC_002695.1 2823515 2824867 D similar to YEGD_ECOLI gi|1788384 (conserved in Escherichia coli K-12); chaperone 2823515..2824867 Escherichia coli O157:H7 str. Sakai 916580 NP_310906.2 CDS ECs2879 NC_002695.1 2824880 2826820 R similar to chaperonin B2070_ECOLI gi|1788385 (conserved in Escherichia coli K-12); chaperonin complement(2824880..2826820) Escherichia coli O157:H7 str. Sakai 916581 NP_310907.1 CDS ECs2880 NC_002695.1 2826817 2827578 R similar to B2072_ECOLI gi|1788387 (conserved in Escherichia coli K-12); hypothetical protein complement(2826817..2827578) Escherichia coli O157:H7 str. Sakai 916582 NP_310908.1 CDS ECs2881 NC_002695.1 2827575 2828234 R similar to B2073_ECOLI gi|1788388 (conserved in Escherichia coli K-12); hypothetical protein complement(2827575..2828234) Escherichia coli O157:H7 str. Sakai 916583 NP_310909.2 CDS ECs2882 NC_002695.1 2829450 2830697 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2829450..2830697 Escherichia coli O157:H7 str. Sakai 916584 NP_310910.1 CDS ECs2883 NC_002695.1 2830697 2833819 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2830697..2833819 Escherichia coli O157:H7 str. Sakai 916585 NP_310911.1 CDS ECs2884 NC_002695.1 2833820 2836897 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2833820..2836897 Escherichia coli O157:H7 str. Sakai 916586 NP_310912.1 CDS ECs2885 NC_002695.1 2836898 2838313 D similar to YEGB_ECOLI gi|1788392 (conserved in Escherichia coli K-12); multidrug efflux system protein MdtE 2836898..2838313 Escherichia coli O157:H7 str. Sakai 916587 NP_310913.1 CDS ECs2886 NC_002695.1 2838310 2839713 D similar to BAES_ECOLI gi|1788393 (conserved in Escherichia coli K-12); signal transduction histidine-protein kinase BaeS 2838310..2839713 Escherichia coli O157:H7 str. Sakai 916588 NP_310914.1 CDS ECs2887 NC_002695.1 2839710 2840432 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; BaeR family transcriptional regulator 2839710..2840432 Escherichia coli O157:H7 str. Sakai 916589 NP_310915.2 CDS ECs2888 NC_002695.1 2840623 2840955 D similar to B2080_ECOLI gi|1788396 (conserved in Escherichia coli K-12); hypothetical protein 2840623..2840955 Escherichia coli O157:H7 str. Sakai 916590 NP_310916.1 CDS ECs2889 NC_002695.1 2841103 2842464 D similar to YEGQ_ECOLI gi|1788397 (conserved in Escherichia coli K-12); hypothetical protein 2841103..2842464 Escherichia coli O157:H7 str. Sakai 916591 NP_310917.1 CDS ECs2890 NC_002695.1 2842627 2842806 R similar to B2084_ECOLI gi|1788400; hypothetical protein complement(2842627..2842806) Escherichia coli O157:H7 str. Sakai 916592 NP_310918.1 CDS ECs2891 NC_002695.1 2842794 2843171 R similar to B2085_ECOLI gi|1788401 (conserved in Escherichia coli K-12); hypothetical protein complement(2842794..2843171) Escherichia coli O157:H7 str. Sakai 916593 NP_310919.1 CDS ECs2892 NC_002695.1 2843517 2844416 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2843517..2844416 Escherichia coli O157:H7 str. Sakai 916594 NP_310920.1 CDS ECs2893 NC_002695.1 2844498 2845277 R similar to GATR_ECOLI sp|P36930 gi|1788403 (conserved in Escherichia coli K-12); split galactitol utilization operon repressor complement(2844498..2845277) Escherichia coli O157:H7 str. Sakai 916595 NP_310921.1 CDS ECs2894 NC_002695.1 2845377 2846417 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2845377..2846417) Escherichia coli O157:H7 str. Sakai 916596 NP_310922.1 CDS ECs2895 NC_002695.1 2846465 2847820 R similar to GATC_ECOLI gi|1788408 (conserved in Escherichia coli K-12); PTS system galactitol-specific enzyme IIC complement(2846465..2847820) Escherichia coli O157:H7 str. Sakai 916597 NP_310923.1 CDS ECs2896 NC_002695.1 2847824 2848108 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB complement(2847824..2848108) Escherichia coli O157:H7 str. Sakai 916598 NP_310924.1 CDS ECs2897 NC_002695.1 2848139 2848591 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA complement(2848139..2848591) Escherichia coli O157:H7 str. Sakai 916599 NP_310925.1 CDS ECs2898 NC_002695.1 2848601 2849863 R similar to GATZ_ECOLI gi|1788411 (conserved in Escherichia coli K-12); tagatose 6-phosphate kinase 1 complement(2848601..2849863) Escherichia coli O157:H7 str. Sakai 916601 NP_310926.2 CDS gatY NC_002695.1 2849892 2850746 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(2849892..2850746) Escherichia coli O157:H7 str. Sakai 916602 NP_310927.2 CDS ECs2900 NC_002695.1 2851045 2852097 R catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase complement(2851045..2852097) Escherichia coli O157:H7 str. Sakai 916603 NP_310928.1 CDS ECs2901 NC_002695.1 2852354 2853631 D similar to YEGT_ECOLI gi|1788415 (conserved in Escherichia coli K-12); nucleoside permease 2852354..2853631 Escherichia coli O157:H7 str. Sakai 916604 NP_310929.1 CDS ECs2902 NC_002695.1 2853628 2854632 D similar to B2099_ECOLI gi|1788416 (conserved in Escherichia coli K-12); hypothetical protein 2853628..2854632 Escherichia coli O157:H7 str. Sakai 916605 NP_310930.1 CDS ECs2903 NC_002695.1 2854629 2855594 D similar to B2100_ECOLI gi|1788417 (conserved in Escherichia coli K-12); kinase 2854629..2855594 Escherichia coli O157:H7 str. Sakai 916606 NP_310931.1 CDS ECs2904 NC_002695.1 2855568 2856314 R similar to YEGW_ECOLI gi|1788418 (conserved in Escherichia coli K-12); transcriptional regulator complement(2855568..2856314) Escherichia coli O157:H7 str. Sakai 916607 NP_310932.1 CDS ECs2905 NC_002695.1 2856366 2857193 R similar to YEGX_ECOLI gi|1788419 (conserved in Escherichia coli K-12); hypothetical protein complement(2856366..2857193) Escherichia coli O157:H7 str. Sakai 916608 NP_310933.1 CDS ECs2906 NC_002695.1 2857249 2858049 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2857249..2858049) Escherichia coli O157:H7 str. Sakai 916609 NP_310934.1 CDS ECs2907 NC_002695.1 2858046 2858834 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2858046..2858834) Escherichia coli O157:H7 str. Sakai 916610 NP_310935.1 CDS ECs2908 NC_002695.1 2859168 2859407 D hypothetical protein 2859168..2859407 Escherichia coli O157:H7 str. Sakai 916611 NP_310936.1 CDS ECs2909 NC_002695.1 2860458 2860805 D hypothetical protein 2860458..2860805 Escherichia coli O157:H7 str. Sakai 916612 NP_310937.1 CDS ECs2910 NC_002695.1 2860815 2861129 D outer membrane protein 2860815..2861129 Escherichia coli O157:H7 str. Sakai 916613 NP_310938.1 CDS ECs2911 NC_002695.1 2861239 2861511 R similar to YOHL_ECOLI gi|1788422 (conserved in Escherichia coli K-12); hypothetical protein complement(2861239..2861511) Escherichia coli O157:H7 str. Sakai 916614 NP_310939.1 CDS ECs2912 NC_002695.1 2861632 2862471 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2861632..2862471 Escherichia coli O157:H7 str. Sakai 916615 NP_310940.2 CDS ECs2913 NC_002695.1 2862689 2863027 D similar to B2107_ECOLI gi|1788424 (conserved in Escherichia coli K-12); hypothetical protein 2862689..2863027 Escherichia coli O157:H7 str. Sakai 916616 NP_310941.1 CDS ECs2914 NC_002695.1 2863109 2864143 R similar to YEHA_ECOLI gi|1788426; type-1 fimbrial protein complement(2863109..2864143) Escherichia coli O157:H7 str. Sakai 916617 NP_310942.1 CDS ECs2915 NC_002695.1 2864154 2866634 R similar to YEHB_ECOLI gi|1788427, ousher protein MrkC [Klebsiella pneumoniae] dad|M55912-4|AAA25095.1; outer membrane protein complement(2864154..2866634) Escherichia coli O157:H7 str. Sakai 916618 NP_310943.1 CDS ECs2916 NC_002695.1 2866650 2867324 R similar to YEHC_ECOLI gi|1788428, chaperone MrkB [Klebsiella pneumoniae] dad|M55912-3|AAA25094.1; chaperone complement(2866650..2867324) Escherichia coli O157:H7 str. Sakai 916619 NP_310944.1 CDS ECs2917 NC_002695.1 2867412 2867954 R similar to YEHD_ECOLI gi|1788429, AC/I pili protein [Escherichia coli] dad|X76121-1|CAA53727.1; fimbrial-like protein complement(2867412..2867954) Escherichia coli O157:H7 str. Sakai 916620 NP_310945.1 CDS ECs2918 NC_002695.1 2868246 2868527 R similar to YEHE_ECOLI gi1788430; hypothetical protein complement(2868246..2868527) Escherichia coli O157:H7 str. Sakai 916621 NP_310946.2 CDS ECs2919 NC_002695.1 2868789 2869898 R similar to MRP_ECOLI gi|1788431 (conserved in Escherichia coli K-12); ATPase complement(2868789..2869898) Escherichia coli O157:H7 str. Sakai 916622 NP_310947.1 CDS metG NC_002695.1 2870030 2872063 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2870030..2872063 Escherichia coli O157:H7 str. Sakai 916623 NP_310952.1 CDS ECs2925 NC_002695.1 2879021 2882650 D similar to YEHI_ECOLI gi|1788436 (conserved in Escherichia coli K-12); regulator 2879021..2882650 Escherichia coli O157:H7 str. Sakai 916628 NP_310953.1 CDS ECs2926 NC_002695.1 2882712 2883029 D similar to YEHK_ECOLI gi|465578|sp|P33347 (conserved in Escherichia coli K-12); hypothetical protein 2882712..2883029 Escherichia coli O157:H7 str. Sakai 916629 NP_310954.1 CDS ECs2927 NC_002695.1 2884204 2885358 D similar to YEHL_ECOLI gi|1788438 (conserved in Escherichia coli K-12); hypothetical protein 2884204..2885358 Escherichia coli O157:H7 str. Sakai 916630 NP_310957.1 CDS ECs2930 NC_002695.1 2887641 2888777 D similar to YEHP_ECOLI gi|1788440 (conserved in Escherichia coli K-12); hypothetical protein 2887641..2888777 Escherichia coli O157:H7 str. Sakai 916633 NP_310958.1 CDS ECs2931 NC_002695.1 2888774 2891011 D similar to YEHQ_ECOLI gi|1788441; hypothetical protein 2888774..2891011 Escherichia coli O157:H7 str. Sakai 916634 NP_310959.1 CDS ECs2932 NC_002695.1 2890818 2891708 R OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase complement(2890818..2891708) Escherichia coli O157:H7 str. Sakai 916635 NP_310960.1 CDS ECs2933 NC_002695.1 2891705 2892031 R OrfA protein of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase complement(2891705..2892031) Escherichia coli O157:H7 str. Sakai 916636 NP_310961.1 CDS ECs2934 NC_002695.1 2892203 2892676 D similar to YEHR_ECOLI gi|1788442 (conserved in Escherichia coli K-12); hypothetical protein 2892203..2892676 Escherichia coli O157:H7 str. Sakai 916637 NP_310962.1 CDS ECs2935 NC_002695.1 2892718 2893188 R similar to YEHS_ECOLI gi|1788443 (conserved in Escherichia coli K-12); hypothetical protein complement(2892718..2893188) Escherichia coli O157:H7 str. Sakai 916638 NP_310963.2 CDS ECs2936 NC_002695.1 2893235 2893954 R unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT complement(2893235..2893954) Escherichia coli O157:H7 str. Sakai 916639 NP_310964.1 CDS ECs2937 NC_002695.1 2893951 2895636 R similar to YEHU_ECOLI gi|1788446 (conserved in Escherichia coli K-12); 2-component sensor protein complement(2893951..2895636) Escherichia coli O157:H7 str. Sakai 916640 NP_310966.1 CDS ECs2939 NC_002695.1 2896151 2896399 D hypothetical protein 2896151..2896399 Escherichia coli O157:H7 str. Sakai 916642 NP_310967.1 CDS ECs2940 NC_002695.1 2896767 2897075 R similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein complement(2896767..2897075) Escherichia coli O157:H7 str. Sakai 916643 NP_310968.1 CDS ECs2941 NC_002695.1 2897038 2898351 R similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein complement(2897038..2898351) Escherichia coli O157:H7 str. Sakai 916644 NP_310969.1 CDS ECs2942 NC_002695.1 2898416 2899015 R similar to Lom precursors e.g. [Bacteriophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein Lom complement(2898416..2899015) Escherichia coli O157:H7 str. Sakai 916645 NP_310972.1 CDS ECs2945 NC_002695.1 2902796 2903473 R similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein complement(2902796..2903473) Escherichia coli O157:H7 str. Sakai 916648 NP_310973.1 CDS ECs2946 NC_002695.1 2903371 2904114 R similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein complement(2903371..2904114) Escherichia coli O157:H7 str. Sakai 916649 NP_310974.1 CDS ECs2947 NC_002695.1 2904125 2904823 R similar to minor tail proteins e.g. GpI[Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein complement(2904125..2904823) Escherichia coli O157:H7 str. Sakai 916650 NP_310975.1 CDS ECs2948 NC_002695.1 2904823 2905152 R similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein complement(2904823..2905152) Escherichia coli O157:H7 str. Sakai 916651 NP_310976.1 CDS ECs2949 NC_002695.1 2905149 2907794 R similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein complement(2905149..2907794) Escherichia coli O157:H7 str. Sakai 916652 NP_310977.1 CDS ECs2950 NC_002695.1 2907838 2908146 R similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein complement(2907838..2908146) Escherichia coli O157:H7 str. Sakai 916653 NP_310978.1 CDS ECs2951 NC_002695.1 2908173 2908595 R similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein complement(2908173..2908595) Escherichia coli O157:H7 str. Sakai 916654 NP_310979.1 CDS ECs2952 NC_002695.1 2908609 2909361 R hypothetical protein complement(2908609..2909361) Escherichia coli O157:H7 str. Sakai 916655 NP_310980.1 CDS ECs2953 NC_002695.1 2909369 2909767 R similar to minor tail proteins e.g. GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein U complement(2909369..2909767) Escherichia coli O157:H7 str. Sakai 916656 NP_310981.1 CDS ECs2954 NC_002695.1 2909780 2910403 R similar to minor tail proteins e.g. GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein complement(2909780..2910403) Escherichia coli O157:H7 str. Sakai 916657 NP_310982.1 CDS ECs2955 NC_002695.1 2910406 2910687 R hypothetical protein complement(2910406..2910687) Escherichia coli O157:H7 str. Sakai 916658 NP_310983.1 CDS ECs2956 NC_002695.1 2910680 2911006 R hypothetical protein complement(2910680..2911006) Escherichia coli O157:H7 str. Sakai 916660 NP_310984.1 CDS ECs2957 NC_002695.1 2911094 2912110 R hypothetical protein complement(2911094..2912110) Escherichia coli O157:H7 str. Sakai 916661 NP_310985.1 CDS ECs2958 NC_002695.1 2912256 2912582 D OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 2912256..2912582 Escherichia coli O157:H7 str. Sakai 916662 NP_310986.1 CDS ECs2959 NC_002695.1 2912579 2913469 D OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 2912579..2913469 Escherichia coli O157:H7 str. Sakai 916663 NP_310987.1 CDS ECs2960 NC_002695.1 2913472 2914578 R similar to scaffolding protein [Streptococcus thermophilus bacteriophage DT1] gi|4530143|gb|AAD21883.1, protease/scaffold protein, ClpP proteases e.g. [Bacteriophage D3] gi|5059251|gb|AAD38956.1; protease/scaffold protein complement(2913472..2914578) Escherichia coli O157:H7 str. Sakai 916664 NP_310988.1 CDS ECs2961 NC_002695.1 2914376 2915878 R similar to portal protein-like protein [Wolbachia sp. wKue] gi|6723246|dbj|BAA89642.1, portal proteins e.g. gp4 [phage 21] gi|549295|sp|P36272|VG04_BPP21; portal protein complement(2914376..2915878) Escherichia coli O157:H7 str. Sakai 916665 NP_310989.1 CDS ECs2962 NC_002695.1 2915878 2916114 R hypothetical protein complement(2915878..2916114) Escherichia coli O157:H7 str. Sakai 916666 NP_310990.1 CDS ECs2963 NC_002695.1 2916087 2918210 R similar to terminase large subunit-like protein [Wolbachia sp. wKue] gi|6723244|dbj|BAA89640.1, terminase large subunits e.g. GpA [Bacteriophage lambda] gi|137616|sp|P0370; terminase large subunit complement(2916087..2918210) Escherichia coli O157:H7 str. Sakai 916667 NP_310991.1 CDS ECs2964 NC_002695.1 2918207 2918683 R hypothetical protein complement(2918207..2918683) Escherichia coli O157:H7 str. Sakai 916668 NP_944551.1 CDS ECs5480 NC_002695.1 2918740 2918988 D hypothetical protein 2918740..2918988 Escherichia coli O157:H7 str. Sakai 2693765 NP_310992.1 CDS ECs2966 NC_002695.1 2919138 2919605 R host cell lysis; similar to Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1|, similar to endopeptidases e.g. Rz [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase complement(2919138..2919605) Escherichia coli O157:H7 str. Sakai 916669 NP_310994.1 CDS ECs2967 NC_002695.1 2919759 2920328 R similar to antirepressor protein [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor protein Ant [Bacteriophage P22]; antirepressor protein complement(2919759..2920328) Escherichia coli O157:H7 str. Sakai 916671 NP_310995.1 CDS ECs2968 NC_002695.1 2920599 2921132 R similar to endolysin [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45, similar to endolysins e.g. R protein [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1; endolysin complement(2920599..2921132) Escherichia coli O157:H7 str. Sakai 916672 NP_310996.1 CDS ECs2969 NC_002695.1 2921137 2921352 R similar to holin [Bacteriophage 933W] gi|4499808|emb|CAB39307.1|, similar to holins e.g. protein S [Bacteriophage 21] gi|138706|sp|P27360|VLYS_BPP21; holin complement(2921137..2921352) Escherichia coli O157:H7 str. Sakai 916673 NP_310997.1 CDS ECs2970 NC_002695.1 2921430 2921675 R similar to hypothetical protein [Shigella dysenteriae] gi|6759966|gb|AAF28124.1|AF153317_20; hypothetical protein complement(2921430..2921675) Escherichia coli O157:H7 str. Sakai 916674 NP_310998.1 CDS ECs2971 NC_002695.1 2921716 2921895 R similar to hypothetical protein [Bacteriophage 933W] gi|4499806|emb|CAB39305.1|; hypothetical protein complement(2921716..2921895) Escherichia coli O157:H7 str. Sakai 916675 NP_310999.1 CDS ECs2972 NC_002695.1 2922033 2923979 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881634|dbj|BAA84325.1|; hypothetical protein complement(2922033..2923979) Escherichia coli O157:H7 str. Sakai 916676 NP_311000.1 CDS ECs2973 NC_002695.1 2924490 2924759 R similar to Shiga toxin I subunit B precursor gi|134539|sp|P08027|SLTB_BPH30; Shiga toxin I subunit B complement(2924490..2924759) Escherichia coli O157:H7 str. Sakai 916677 NP_311001.1 CDS ECs2974 NC_002695.1 2924769 2925716 R similar to Shiga toxin I subunit A precursor [Shigella dysenteriae] gi|134537|sp|P10149|SLTA_BPH30; Shiga toxin I subunit A complement(2924769..2925716) Escherichia coli O157:H7 str. Sakai 916678 NP_311002.1 CDS ECs2975 NC_002695.1 2926223 2926657 R similar to antitermination proteins e.g. protein Q [Bacteriophage H-19B]; antitermination protein complement(2926223..2926657) Escherichia coli O157:H7 str. Sakai 916679 NP_311003.1 CDS ECs2976 NC_002695.1 2926650 2926844 R similar to hypothetical proteins e.g. Nin 68 [Bacteriophage lambda] gi|1351593|sp|P03771|Y68_LAMBD; hypothetical protein complement(2926650..2926844) Escherichia coli O157:H7 str. Sakai 916680 NP_311004.1 CDS ECs2977 NC_002695.1 2926841 2927446 R similar to hypothetical proteins e.g. NinG protein [Bacteriophage 21] gi|4539482|emb|CAB39991.1|; hypothetical protein complement(2926841..2927446) Escherichia coli O157:H7 str. Sakai 916681 NP_311005.1 CDS ECs2978 NC_002695.1 2927439 2927648 R similar to hypothetical proteins e.g., NinF [Bacteriophage P22] gi|512350|emb|CAA55162.1|; hypothetical protein complement(2927439..2927648) Escherichia coli O157:H7 str. Sakai 916682 NP_311006.1 CDS ECs2979 NC_002695.1 2927608 2928009 R hypothetical protein complement(2927608..2928009) Escherichia coli O157:H7 str. Sakai 916683 NP_311007.1 CDS ECs2980 NC_002695.1 2928012 2928188 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881625|dbj|BAA84316.1|, Nin E proteins e.g. [Bacteriophage 21]; protein NinE complement(2928012..2928188) Escherichia coli O157:H7 str. Sakai 916684 NP_311008.1 CDS ECs2981 NC_002695.1 2928185 2928712 R similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881624|dbj|BAA84315.1|, DNA N-6-adenine-methyltransferase [Bacteriophage T1]; DNA methylase complement(2928185..2928712) Escherichia coli O157:H7 str. Sakai 916685 NP_311009.1 CDS ECs2982 NC_002695.1 2928709 2929155 R similar to hypothetical protein [Bacteriophage 933W] gi|4585410|gb|AAD25438.1|AF125520_33, NinB [Bacteriophage 21] gi|4539479|emb|CAB39988.1|; hypothetical protein complement(2928709..2929155) Escherichia coli O157:H7 str. Sakai 916686 NP_311010.1 CDS ECs2983 NC_002695.1 2929112 2929537 R similar to hypothetical protein [Bacteriophage 933W] gi|4585409|gb|AAD25437.1|AF125520_32; hypothetical protein complement(2929112..2929537) Escherichia coli O157:H7 str. Sakai 916687 NP_311011.1 CDS ECs2984 NC_002695.1 2929707 2929985 R similar to hypothetical protein [Bacteriophage 933W] gi|4499788|emb|CAB39287.1|; hypothetical protein complement(2929707..2929985) Escherichia coli O157:H7 str. Sakai 916688 NP_311012.1 CDS ECs2985 NC_002695.1 2930056 2930346 R similar to Ren proteins e.g. [Bacteriophage lambda] gi|139473|sp|P03761|VREN_LAMBD; Ren protein complement(2930056..2930346) Escherichia coli O157:H7 str. Sakai 916689 NP_311013.1 CDS ECs2986 NC_002695.1 2930343 2931044 R similar to phage replication protein P e.g. [Bacteriophage lambda] gi|139488|sp|P03689|VRPP_LAMBD; phage replication protein P complement(2930343..2931044) Escherichia coli O157:H7 str. Sakai 916690 NP_311014.1 CDS ECs2987 NC_002695.1 2931041 2931979 R similar to phage replication protein O e.g. [Bacteriophage 933W] gi|4585405|gb|AAD25433.1|AF125520_28; phage replication protein O complement(2931041..2931979) Escherichia coli O157:H7 str. Sakai 916691 NP_311015.1 CDS ECs2988 NC_002695.1 2932012 2932308 R similar to regulatory protein CII e.g. [Bacteriophage 933W] gi|4585404|gb|AAD25432.1|AF125520_27; regulatory protein CII complement(2932012..2932308) Escherichia coli O157:H7 str. Sakai 916692 NP_311016.1 CDS ECs2989 NC_002695.1 2932423 2932641 R similar to probable regulatory proteins e.g. [Bacteriophage VT2-Sa] gi|5881616|dbj|BAA84307.1|; regulatory protein complement(2932423..2932641) Escherichia coli O157:H7 str. Sakai 916693 NP_311017.1 CDS ECs2990 NC_002695.1 2932759 2933397 D similar to prophage repressor CI e.g. [Bacteriophage lambda] gi|133353|sp|P03034|RPC1_LAMBD; prophage repressor CI 2932759..2933397 Escherichia coli O157:H7 str. Sakai 916694 NP_311018.1 CDS ECs2991 NC_002695.1 2933520 2933801 D hypothetical protein 2933520..2933801 Escherichia coli O157:H7 str. Sakai 916695 NP_311019.1 CDS ECs2992 NC_002695.1 2933808 2934359 D hypothetical protein 2933808..2934359 Escherichia coli O157:H7 str. Sakai 916696 NP_311021.1 CDS ECs2993 NC_002695.1 2934872 2935144 D transcription anti-termination; similar to transcription anti-termination proteins e.g. protein N [Bacteriophage phi-21] gi|132274|sp|P07243|REGN_BPPH3; regulatory protein 2934872..2935144 Escherichia coli O157:H7 str. Sakai 916698 NP_311022.1 CDS ECs2995 NC_002695.1 2935161 2935742 R similar to superinfection exclusion protein B [Bacteriophage P22] gi|585991|sp|P38396|SIEB_BPP22; superinfection exclusion protein complement(2935161..2935742) Escherichia coli O157:H7 str. Sakai 916699 NP_311023.1 CDS ECs2996 NC_002695.1 2936003 2936371 D similar to single-stranded DNA binding protein [Bacteriophage 933W], Ea10 (single-stranded DNA binding protein) [Bacteriophage lambda] gi|137630|sp|P03757|VE10_LAMBD; single-stranded DNA binding protein 2936003..2936371 Escherichia coli O157:H7 str. Sakai 916700 NP_311024.1 CDS ECs2997 NC_002695.1 2936444 2936608 D antitermination; similar to regulatory proteins cIII [Bacteriophage lambda] gi|133366|sp|P03044|RPC3_LAMBD; regulatory protein cIII 2936444..2936608 Escherichia coli O157:H7 str. Sakai 916701 NP_311025.1 CDS ECs2998 NC_002695.1 2936451 2936720 D host killing; similar to Kil proteins e.g. [Bacteriophage lambda] gi|138622|sp|P03758|VKIL_LAMBD; Kil protein 2936451..2936720 Escherichia coli O157:H7 str. Sakai 916702 NP_311028.1 CDS ECs3001 NC_002695.1 2937098 2937883 D recombination protein; similar to Bet protein [Bacteriophage 933W] gi|4585391|gb|AAD25419.1|AF125520_14, Bet protein [Bacteriophage lambda] gi|137511|sp|P03698|VBET_LAMBD; hypothetical protein 2937098..2937883 Escherichia coli O157:H7 str. Sakai 916705 NP_311029.1 CDS ECs3002 NC_002695.1 2937880 2938557 D similar to exonucleases [Bacteriophage 933W] gi|4585390|gb|AAD25418.1|AF125520_13, exonucleases e.g. [Bacteriophage lambda] gi|119702|sp|P03697|EXO_LAMBD; exonuclease 2937880..2938557 Escherichia coli O157:H7 str. Sakai 916706 NP_311030.1 CDS ECs3003 NC_002695.1 2938551 2938739 D similar to hypothetical protein [Bacteriophage 933W] gi|4585389|gb|AAD25417.1|AF125520_12, hypothetical protein orf60a [Bacteriophage lambda] gi|508995|gb|AAA96568.1|; hypothetical protein 2938551..2938739 Escherichia coli O157:H7 str. Sakai 916707 NP_311031.1 CDS ECs3004 NC_002695.1 2938712 2938903 D similar to hypothetical protein [Bacteriophage 933W] gi|4585388|gb|AAD25416.1|AF125520_11, orf63 [Bacteriophage lambda] gi|508994|gb|AAA96567.1|; hypothetical protein 2938712..2938903 Escherichia coli O157:H7 str. Sakai 916708 NP_311032.1 CDS ECs3005 NC_002695.1 2938914 2939195 D similar to hypothetical protein [Bacteriophage 933W] gi|4585387|gb|AAD25415.1|AF125520_10, hypothetical protein orf61 [Bacteriophage lambda]; hypothetical protein 2938914..2939195 Escherichia coli O157:H7 str. Sakai 916709 NP_311033.1 CDS ECs3006 NC_002695.1 2939294 2939515 D similar to C4-type zinc finger proteins (TraR family) e.g. gi|7649830|dbj|BAA94108.1; C4-type zinc finger protein 2939294..2939515 Escherichia coli O157:H7 str. Sakai 916710 NP_311034.1 CDS ECs3007 NC_002695.1 2939512 2940459 D similar to hypothetical protein Bacteriophage 933W AAD25483, hypothetical protein Bacteriophage HK022 AAF30379; hypothetical protein 2939512..2940459 Escherichia coli O157:H7 str. Sakai 916711 NP_944552.1 CDS ECs5481 NC_002695.1 2940687 2940974 D hypothetical protein 2940687..2940974 Escherichia coli O157:H7 str. Sakai 2693766 NP_311036.1 CDS ECs3009 NC_002695.1 2940971 2941327 D similar to hypothetical protein Bacteriophage 933W AAD25410; hypothetical protein 2940971..2941327 Escherichia coli O157:H7 str. Sakai 916713 NP_311037.1 CDS ECs3010 NC_002695.1 2941324 2941686 D similar to hypothetical proteins e.g. [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein 2941324..2941686 Escherichia coli O157:H7 str. Sakai 916714 NP_311038.1 CDS ECs3011 NC_002695.1 2941774 2942016 D hypothetical protein 2941774..2942016 Escherichia coli O157:H7 str. Sakai 916715 NP_944553.1 CDS ECs5482 NC_002695.1 2942020 2942154 D hypothetical protein 2942020..2942154 Escherichia coli O157:H7 str. Sakai 2693767 NP_311039.1 CDS ECs3012 NC_002695.1 2942173 2942427 D similar to excisionases e.g. [Bacteriophage 933W] gi|4585379|gb|AAD25407.1|AF125520_2; excisionase 2942173..2942427 Escherichia coli O157:H7 str. Sakai 916716 NP_311040.1 CDS ECs3013 NC_002695.1 2942461 2943747 D similar to integrases e.g. [Bacteriophage 933W] gi|4585378|gb|AAD25406.1|AF125520_1; integrase 2942461..2943747 Escherichia coli O157:H7 str. Sakai 916717 NP_311041.1 CDS ECs3014 NC_002695.1 2943822 2944469 D similar to YEHV_ECOLI gi|1788448 (conserved in Escherichia coli K-12); transcriptional regulator 2943822..2944469 Escherichia coli O157:H7 str. Sakai 916718 NP_311042.1 CDS ECs3015 NC_002695.1 2944617 2945348 R similar to YEHW_ECOLI gi|1788449 (conserved in Escherichia coli K-12); transport system permease complement(2944617..2945348) Escherichia coli O157:H7 str. Sakai 916719 NP_311043.1 CDS ECs3016 NC_002695.1 2945353 2946279 R similar to YEHX_ECOLI gi|1788450 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(2945353..2946279) Escherichia coli O157:H7 str. Sakai 916720 NP_311044.1 CDS ECs3017 NC_002695.1 2946272 2947429 R similar to YEHY_ECOLI gi|1788451 (conserved in Escherichia coli K-12); transport system permease complement(2946272..2947429) Escherichia coli O157:H7 str. Sakai 916721 NP_311045.1 CDS ECs3018 NC_002695.1 2947436 2948353 R similar to YEHZ_ECOLI gi|1788452 (conserved in Escherichia coli K-12); transport system permease complement(2947436..2948353) Escherichia coli O157:H7 str. Sakai 916722 NP_311046.1 CDS ECs3019 NC_002695.1 2948605 2950902 R similar to BGLX_ECOLI gi|1788453 (conserved in Escherichia coli K-12); beta-D-glucoside glucohydrolase complement(2948605..2950902) Escherichia coli O157:H7 str. Sakai 916723 NP_311047.1 CDS ECs3020 NC_002695.1 2951098 2952813 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2951098..2952813 Escherichia coli O157:H7 str. Sakai 916724 NP_311048.1 CDS pbpG NC_002695.1 2952851 2953792 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(2952851..2953792) Escherichia coli O157:H7 str. Sakai 916725 NP_311049.1 CDS ECs3022 NC_002695.1 2953957 2954568 R similar to YOHC_ECOLI gi|1788457 (conserved in Escherichia coli K-12); hypothetical protein complement(2953957..2954568) Escherichia coli O157:H7 str. Sakai 916726 NP_311050.1 CDS ECs3023 NC_002695.1 2954678 2955292 D similar to YOHD_ECOLI gi|1788458 (conserved in Escherichia coli K-12); hypothetical protein 2954678..2955292 Escherichia coli O157:H7 str. Sakai 916727 NP_311051.1 CDS ECs3024 NC_002695.1 2955422 2956183 R similar to YOHF_ECOLI gi|1788459 (conserved in Escherichia coli K-12); acetoin dehydrogenase complement(2955422..2956183) Escherichia coli O157:H7 str. Sakai 916728 NP_311052.2 CDS ECs3025 NC_002695.1 2956236 2957672 R may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ complement(2956236..2957672) Escherichia coli O157:H7 str. Sakai 916729 NP_311053.1 CDS ECs3026 NC_002695.1 2958367 2959317 R similar to YOHI_ECOLI gi|1788462 (conserved in Escherichia coli K-12); tRNA-dihydrouridine synthase C complement(2958367..2959317) Escherichia coli O157:H7 str. Sakai 916730 NP_311054.1 CDS ECs3027 NC_002695.1 2959477 2960670 R catalyzes the formation of catechol from salicylate; salicylate hydroxylase complement(2959477..2960670) Escherichia coli O157:H7 str. Sakai 916731 NP_311055.1 CDS ECs3028 NC_002695.1 2960685 2961332 R similar to glutathione-S-transferases e.g. [Pseudomonas sp. U2] gi|3406829|gb|AAC29501.1|; glutathione-S-transferase complement(2960685..2961332) Escherichia coli O157:H7 str. Sakai 916732 NP_311056.1 CDS ECs3029 NC_002695.1 2961338 2962039 R similar to isomerase e.g. isomerase-decarboxylase homolog [Pseudomonas sp. U2] gi|3406828|gb|AAC29500.1, hypothetical protein Orf2 [Sphingomonas sp. RW5] gi|3550668|emb|CAA12268.1|; isomerase complement(2961338..2962039) Escherichia coli O157:H7 str. Sakai 916733 NP_311057.1 CDS ECs3030 NC_002695.1 2962054 2963082 R similar to gentisate 1,2-dioxygenases e.g. [Pseudomonas alcaligenes] gi|5733104|gb|AAD49427.1|AF173167_1, [Sphingomonas sp. RW5] gi|3550667|emb|CAA12267.1|; gentisate 1,2-dioxygenase complement(2962054..2963082) Escherichia coli O157:H7 str. Sakai 916734 NP_311058.1 CDS ECs3031 NC_002695.1 2963094 2964452 R similar to transport proteins e.g. 4-hydroxybenzoate transporter [Pseudomonas putida] gi|6093655|sp|Q51955|PCAK_PSEPU; transporter complement(2963094..2964452) Escherichia coli O157:H7 str. Sakai 916735 NP_311059.2 CDS ECs3032 NC_002695.1 2964579 2965487 D similar to regulatory proteins e.g. galactose binding protein regulator [Azospirillum brasilense] gi|1730232|sp|P52661|GBPR_AZOBR; regulatory protein 2964579..2965487 Escherichia coli O157:H7 str. Sakai 916736 NP_311060.1 CDS ECs3033 NC_002695.1 2965618 2966016 D similar to YOHJ_ECOLI gi|1788463 (conserved in Escherichia coli K-12); hypothetical protein 2965618..2966016 Escherichia coli O157:H7 str. Sakai 916737 NP_311061.1 CDS ECs3034 NC_002695.1 2966013 2966708 D similar to YOHK_ECOLI gi|1788464 (conserved in Escherichia coli K-12); hypothetical protein 2966013..2966708 Escherichia coli O157:H7 str. Sakai 916738 NP_311062.1 CDS ECs3035 NC_002695.1 2966838 2967722 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2966838..2967722 Escherichia coli O157:H7 str. Sakai 916739 NP_311063.1 CDS ECs3036 NC_002695.1 2967872 2968591 D similar to SANA_ECOLI gi|1788466 (conserved in Escherichia coli K-12); hypothetical protein 2967872..2968591 Escherichia coli O157:H7 str. Sakai 916740 NP_311064.1 CDS ECs3037 NC_002695.1 2968594 2968833 D similar to B2145_ECOLI gi|1788467 (conserved in Escherichia coli K-12); hypothetical protein 2968594..2968833 Escherichia coli O157:H7 str. Sakai 916741 NP_311065.1 CDS ECs3038 NC_002695.1 2969027 2970265 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2969027..2970265 Escherichia coli O157:H7 str. Sakai 916742 NP_311066.2 CDS ECs3039 NC_002695.1 2970259 2971494 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2970259..2971494 Escherichia coli O157:H7 str. Sakai 916743 NP_311067.1 CDS mglC NC_002695.1 2971737 2972747 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein complement(2971737..2972747) Escherichia coli O157:H7 str. Sakai 916744 NP_311068.1 CDS ECs3041 NC_002695.1 2972763 2974283 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2972763..2974283) Escherichia coli O157:H7 str. Sakai 916745 NP_311069.1 CDS ECs3042 NC_002695.1 2974344 2975342 R similar to MGLB_ECOLI gi|1788473 (conserved in Escherichia coli K-12); galactose-binding transport protein complement(2974344..2975342) Escherichia coli O157:H7 str. Sakai 916746 NP_311070.1 CDS ECs3043 NC_002695.1 2975621 2976661 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2975621..2976661) Escherichia coli O157:H7 str. Sakai 916747 NP_311071.1 CDS ECs3044 NC_002695.1 2976803 2977960 R similar to YEIB_ECOLI gi|1788475 (conserved in Escherichia coli K-12); hypothetical protein complement(2976803..2977960) Escherichia coli O157:H7 str. Sakai 916748 NP_311072.1 CDS folE NC_002695.1 2977977 2978645 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2977977..2978645) Escherichia coli O157:H7 str. Sakai 916749 NP_311073.1 CDS ECs3046 NC_002695.1 2978903 2979739 D similar to YEIG_ECOLI gi|1788477 (conserved in Escherichia coli K-12); esterase 2978903..2979739 Escherichia coli O157:H7 str. Sakai 916750 NP_311074.1 CDS ECs3047 NC_002695.1 2979771 2981750 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(2979771..2981750) Escherichia coli O157:H7 str. Sakai 916751 NP_311075.1 CDS ECs3048 NC_002695.1 2982042 2983511 R similar to LYSP_ECOLI gi|1788480 (conserved in Escherichia coli K-12); lysine transporter complement(2982042..2983511) Escherichia coli O157:H7 str. Sakai 916752 NP_311076.1 CDS ECs3049 NC_002695.1 2983716 2984597 R similar to YEIE_ECOLI gi|1788481 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator complement(2983716..2984597) Escherichia coli O157:H7 str. Sakai 916753 NP_311077.1 CDS ECs3050 NC_002695.1 2984696 2985745 D similar to YEIH_ECOLI gi|1788482 (conserved in Escherichia coli K-12); hypothetical protein 2984696..2985745 Escherichia coli O157:H7 str. Sakai 916754 NP_311078.1 CDS ECs3051 NC_002695.1 2985819 2986676 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2985819..2986676 Escherichia coli O157:H7 str. Sakai 916755 NP_311079.1 CDS ECs3052 NC_002695.1 2986679 2987767 D similar to YEII_ECOLI gi|1788484 (conserved in Escherichia coli K-12); hypothetical protein 2986679..2987767 Escherichia coli O157:H7 str. Sakai 916756 NP_311080.1 CDS ECs3053 NC_002695.1 2987823 2989073 R similar to YEIJ_ECOLI gi|1788485 (conserved in Escherichia coli K-12); transport system permease complement(2987823..2989073) Escherichia coli O157:H7 str. Sakai 916757 NP_311081.1 CDS rihB NC_002695.1 2989173 2990114 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2989173..2990114) Escherichia coli O157:H7 str. Sakai 916758 NP_311082.2 CDS ECs3055 NC_002695.1 2990244 2990942 D activator of nucleoside metabolism; YeiL family transcriptional regulator 2990244..2990942 Escherichia coli O157:H7 str. Sakai 916759 NP_311083.1 CDS ECs3056 NC_002695.1 2991013 2992263 R similar to YEIJ_ECOLI gi|1788485 (conserved in Escherichia coli K-12); transport system permease complement(2991013..2992263) Escherichia coli O157:H7 str. Sakai 916760 NP_311084.1 CDS ECs3057 NC_002695.1 2992357 2993295 R similar to YEIN_ECOLI gi|1788490 (conserved in Escherichia coli K-12); hypothetical protein complement(2992357..2993295) Escherichia coli O157:H7 str. Sakai 916761 NP_311085.1 CDS ECs3058 NC_002695.1 2993283 2994224 R similar to YEIC_ECOLI gi|1788491 (conserved in Escherichia coli K-12); hypothetical protein complement(2993283..2994224) Escherichia coli O157:H7 str. Sakai 916762 NP_311086.1 CDS ECs3059 NC_002695.1 2994648 2996339 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC complement(2994648..2996339) Escherichia coli O157:H7 str. Sakai 916763 NP_311087.1 CDS fruK NC_002695.1 2996356 2997294 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2996356..2997294) Escherichia coli O157:H7 str. Sakai 916764 NP_311088.1 CDS ECs3061 NC_002695.1 2997294 2998424 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(2997294..2998424) Escherichia coli O157:H7 str. Sakai 916765 NP_311089.1 CDS ECs3062 NC_002695.1 2998792 2999973 D similar to SETB_ECOLI gi|465603|sp|P33026 (conserved in Escherichia coli K-12); sugar efflux transport protein 2998792..2999973 Escherichia coli O157:H7 str. Sakai 916766 NP_311090.2 CDS ECs3063 NC_002695.1 3000379 3000951 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 3000379..3000951 Escherichia coli O157:H7 str. Sakai 916767 NP_311091.1 CDS ECs3064 NC_002695.1 3001174 3002640 D similar to YEIQ_ECOLI gi|1788497 (conserved in Escherichia coli K-12); oxidoreductase 3001174..3002640 Escherichia coli O157:H7 str. Sakai 916768 NP_311092.1 CDS ECs3065 NC_002695.1 3002758 3003744 D similar to YEIR_ECOLI gi|1788499 (conserved in Escherichia coli K-12); hypothetical protein 3002758..3003744 Escherichia coli O157:H7 str. Sakai 916769 NP_311093.2 CDS ECs3066 NC_002695.1 3003783 3004496 D similar to B2174_ECOLI gi|1788500 (conserved in Escherichia coli K-12); hypothetical protein 3003783..3004496 Escherichia coli O157:H7 str. Sakai 916770 NP_311094.1 CDS spr NC_002695.1 3004909 3005475 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 3004909..3005475 Escherichia coli O157:H7 str. Sakai 916771 NP_311095.1 CDS ECs3068 NC_002695.1 3005656 3007212 D similar to RTN_ECOLI gi|1788502 (conserved in Escherichia coli K-12); hypothetical protein 3005656..3007212 Escherichia coli O157:H7 str. Sakai 916772 NP_311096.2 CDS ECs3069 NC_002695.1 3007294 3009108 D similar to YEJA_ECOLI gi|1788503 (conserved in Escherichia coli K-12); hypothetical protein 3007294..3009108 Escherichia coli O157:H7 str. Sakai 916773 NP_311097.1 CDS ECs3070 NC_002695.1 3009109 3010203 D similar to YEJB_ECOLI gi|1788504 (conserved in Escherichia coli K-12); transport system permease 3009109..3010203 Escherichia coli O157:H7 str. Sakai 916774 NP_311098.1 CDS ECs3071 NC_002695.1 3010203 3011228 D similar to YEJE_ECOLI gi|1788505 (conserved in Escherichia coli K-12); transport system permease 3010203..3011228 Escherichia coli O157:H7 str. Sakai 916775 NP_311099.1 CDS ECs3072 NC_002695.1 3011230 3012819 D similar to YEJF_ECOLI gi|1788506 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 3011230..3012819 Escherichia coli O157:H7 str. Sakai 916776 NP_311100.1 CDS ECs3073 NC_002695.1 3012823 3013167 R similar to YEJG_ECOLI gi|1788507 (conserved in Escherichia coli K-12); hypothetical protein complement(3012823..3013167) Escherichia coli O157:H7 str. Sakai 916777 NP_311101.1 CDS ECs3074 NC_002695.1 3013500 3014690 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein complement(3013500..3014690) Escherichia coli O157:H7 str. Sakai 916778 NP_311102.1 CDS ECs3075 NC_002695.1 3014718 3015413 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(3014718..3015413) Escherichia coli O157:H7 str. Sakai 916779 NP_311103.1 CDS ECs3076 NC_002695.1 3015562 3017322 D similar to YEJH_ECOLI gi|1788511 (conserved in Escherichia coli K-12); ATP-dependent helicase 3015562..3017322 Escherichia coli O157:H7 str. Sakai 916780 NP_311104.1 CDS ECs3077 NC_002695.1 3017447 3017731 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 3017447..3017731 Escherichia coli O157:H7 str. Sakai 916782 NP_311105.1 CDS ECs3078 NC_002695.1 3017870 3018877 R similar to YEJK_ECOLI gi|465615|sp|P33920 (conserved in Escherichia coli K-12); nucleoid-associated protein NdpA complement(3017870..3018877) Escherichia coli O157:H7 str. Sakai 916783 NP_311106.1 CDS ECs3079 NC_002695.1 3019059 3019286 D similar to YEJL_ECOLI gi|1788514 (conserved in Escherichia coli K-12); hypothetical protein 3019059..3019286 Escherichia coli O157:H7 str. Sakai 916784 NP_311107.1 CDS ECs3080 NC_002695.1 3019306 3021066 D similar to YEJM_ECOLI gi|1788515 (conserved in Escherichia coli K-12); sulfatase 3019306..3021066 Escherichia coli O157:H7 str. Sakai 916785 NP_311108.1 CDS ECs3081 NC_002695.1 3021318 3023828 R similar to YEJO_ECOLI gi|1788516 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(3021318..3023828) Escherichia coli O157:H7 str. Sakai 916787 NP_311109.1 CDS ECs3082 NC_002695.1 3024229 3024876 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 3024229..3024876 Escherichia coli O157:H7 str. Sakai 916788 NP_311110.1 CDS ECs3083 NC_002695.1 3024911 3025963 R similar to CCMH_ECOLI gi|1788522 (conserved in Escherichia coli K-12); cytochrome c-type biogenesis protein; CcmH precursor complement(3024911..3025963) Escherichia coli O157:H7 str. Sakai 916789 NP_311111.1 CDS ECs3084 NC_002695.1 3025960 3026517 R similar to DSBE_ECOLI gi|1788523 (conserved in Escherichia coli K-12); thiol:disulfide interchange protein; DsbE complement(3025960..3026517) Escherichia coli O157:H7 str. Sakai 916790 NP_311112.1 CDS ECs3085 NC_002695.1 3026514 3028457 R similar to CCMF_ECOLI gi|1788524 (conserved in Escherichia coli K-12); cytochrome c-type biogenesis protein complement(3026514..3028457) Escherichia coli O157:H7 str. Sakai 916791 NP_311113.1 CDS ECs3086 NC_002695.1 3028454 3028933 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(3028454..3028933) Escherichia coli O157:H7 str. Sakai 916792 NP_311114.1 CDS ECs3087 NC_002695.1 3028930 3029139 R similar to CCMD_ECOLI gi|1788526 (conserved in Escherichia coli K-12); heme exporter protein C complement(3028930..3029139) Escherichia coli O157:H7 str. Sakai 916793 NP_311115.1 CDS ECs3088 NC_002695.1 3029136 3029873 R similar to CCMC_ECOLI gi|1788527 (conserved in Escherichia coli K-12); heme exporter protein C complement(3029136..3029873) Escherichia coli O157:H7 str. Sakai 916794 NP_311116.1 CDS ECs3089 NC_002695.1 3029915 3030577 R similar to CCMB_ECOLI gi|1788528 (conserved in Escherichia coli K-12); heme exporter protein B complement(3029915..3030577) Escherichia coli O157:H7 str. Sakai 916795 NP_311117.1 CDS ECs3090 NC_002695.1 3030574 3031191 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(3030574..3031191) Escherichia coli O157:H7 str. Sakai 916796 NP_311118.1 CDS ECs3091 NC_002695.1 3031210 3031812 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(3031210..3031812) Escherichia coli O157:H7 str. Sakai 916797 NP_311119.2 CDS napB NC_002695.1 3031822 3032271 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(3031822..3032271) Escherichia coli O157:H7 str. Sakai 916798 NP_311120.1 CDS napH NC_002695.1 3032268 3033131 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(3032268..3033131) Escherichia coli O157:H7 str. Sakai 916799 NP_311121.1 CDS napG NC_002695.1 3033118 3033813 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(3033118..3033813) Escherichia coli O157:H7 str. Sakai 916800 NP_311122.1 CDS ECs3095 NC_002695.1 3033820 3036306 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(3033820..3036306) Escherichia coli O157:H7 str. Sakai 916801 NP_311123.1 CDS ECs3096 NC_002695.1 3036303 3036566 R similar to NAPD_ECOLI gi|1788535 (conserved in Escherichia coli K-12); assembly protein for periplasmic nitrate reductase complement(3036303..3036566) Escherichia coli O157:H7 str. Sakai 916802 NP_311124.1 CDS ECs3097 NC_002695.1 3036556 3037050 R Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein complement(3036556..3037050) Escherichia coli O157:H7 str. Sakai 916803 NP_311125.1 CDS ECs3098 NC_002695.1 3037457 3037945 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 3037457..3037945 Escherichia coli O157:H7 str. Sakai 916804 NP_311126.1 CDS ECs3099 NC_002695.1 3038095 3039741 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(3038095..3039741) Escherichia coli O157:H7 str. Sakai 916805 NP_311127.1 CDS ECs3100 NC_002695.1 3039959 3041602 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component complement(3039959..3041602) Escherichia coli O157:H7 str. Sakai 916806 NP_311128.1 CDS ECs3101 NC_002695.1 3041678 3042328 R similar to ALKB_ECOLI gi|1788541 (conserved in Escherichia coli K-12); alkylated DNA repair protein complement(3041678..3042328) Escherichia coli O157:H7 str. Sakai 916807 NP_311129.1 CDS ECs3102 NC_002695.1 3042328 3043392 R similar to ADA_ECOLI gi|1788542 (conserved in Escherichia coli K-12); O6-methylguanine-DNA methyltransferase complement(3042328..3043392) Escherichia coli O157:H7 str. Sakai 916808 NP_944554.1 CDS ECs5484 NC_002695.1 3043126 3043344 D hypothetical protein 3043126..3043344 Escherichia coli O157:H7 str. Sakai 2693802 NP_311130.1 CDS ECs3103 NC_002695.1 3043466 3044521 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(3043466..3044521) Escherichia coli O157:H7 str. Sakai 916810 NP_311131.1 CDS ECs3104 NC_002695.1 3044633 3045736 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(3044633..3045736) Escherichia coli O157:H7 str. Sakai 916811 NP_311132.1 CDS ECs3105 NC_002695.1 3046475 3049147 D similar to YOJN_ECOLI gi|1788545 (conserved in Escherichia coli K-12); phosphotransfer intermediate protein in two-component regulatory system with RcsBC 3046475..3049147 Escherichia coli O157:H7 str. Sakai 916813 NP_311133.1 CDS ECs3106 NC_002695.1 3049164 3049814 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 3049164..3049814 Escherichia coli O157:H7 str. Sakai 916814 NP_311134.2 CDS ECs3107 NC_002695.1 3050014 3052863 R similar to RCSC_ECOLI gi|1788548 (conserved in Escherichia coli K-12); hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(3050014..3052863) Escherichia coli O157:H7 str. Sakai 916815 NP_311135.1 CDS ECs3108 NC_002695.1 3053138 3053914 R similar to B2225_ECOLI gi|1788556 (conserved in Escherichia coli K-12); hypothetical protein complement(3053138..3053914) Escherichia coli O157:H7 str. Sakai 916816 NP_311136.1 CDS ECs3109 NC_002695.1 3053919 3054620 R similar to C-terminal part of B2226_ECOLI gi|1788557; may contain frameshift; hypothetical protein complement(3053919..3054620) Escherichia coli O157:H7 str. Sakai 916817 NP_311137.1 CDS ECs3110 NC_002695.1 3054774 3055568 R similar to N-terminal part of B2226_ECOLI gi|1788557; may contain frameshift; hypothetical protein complement(3054774..3055568) Escherichia coli O157:H7 str. Sakai 916818 NP_311138.1 CDS ECs3111 NC_002695.1 3055569 3060173 R similar to membrane protein B2228_ECOLI gi|1788559, B2227_ECOLI to gi|1788558; hypothetical protein complement(3055569..3060173) Escherichia coli O157:H7 str. Sakai 916819 NP_311139.2 CDS ECs3112 NC_002695.1 3060107 3060730 R similar to B2229_ECOLI gi|1788560 (conserved in Escherichia coli K-12); hypothetical protein complement(3060107..3060730) Escherichia coli O157:H7 str. Sakai 916820 NP_311140.2 CDS ECs3113 NC_002695.1 3060727 3062325 R similar to YFAA_ECOLI gi|1788561; hypothetical protein complement(3060727..3062325) Escherichia coli O157:H7 str. Sakai 916821 NP_311141.1 CDS ECs3114 NC_002695.1 3062563 3065190 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(3062563..3065190) Escherichia coli O157:H7 str. Sakai 916822 NP_311142.1 CDS ECs3115 NC_002695.1 3065337 3066059 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 3065337..3066059 Escherichia coli O157:H7 str. Sakai 916823 NP_311143.1 CDS ECs3116 NC_002695.1 3066200 3069952 R similar to YFAL_ECOLI gi|1788565 (conserved in Escherichia coli K-12); adhesin complement(3066200..3069952) Escherichia coli O157:H7 str. Sakai 916824 NP_311144.1 CDS ECs3117 NC_002695.1 3070648 3072933 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3070648..3072933 Escherichia coli O157:H7 str. Sakai 916825 NP_311145.1 CDS nrdB NC_002695.1 3073160 3074290 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 3073160..3074290 Escherichia coli O157:H7 str. Sakai 916826 NP_311146.1 CDS ECs3119 NC_002695.1 3074290 3074544 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 3074290..3074544 Escherichia coli O157:H7 str. Sakai 916827 NP_311147.1 CDS ECs3120 NC_002695.1 3074598 3075248 R similar to INAA_ECOLI gi|1788569 (conserved in Escherichia coli K-12); hypothetical protein complement(3074598..3075248) Escherichia coli O157:H7 str. Sakai 916828 NP_311148.1 CDS ECs3121 NC_002695.1 3075329 3076519 R similar to antibiotic resistance protein homolog YwoG [Bacillus subtilis] gi|7474437|pir||B70065; antibiotic resistance protein complement(3075329..3076519) Escherichia coli O157:H7 str. Sakai 916829 NP_311149.1 CDS ECs3122 NC_002695.1 3076671 3077549 D similar to transcriptional regulators e.g. YvbU [Bacillus subtilis] gi|6648030|sp|O32255; transcriptional regulator 3076671..3077549 Escherichia coli O157:H7 str. Sakai 916830 NP_311150.1 CDS ECs3123 NC_002695.1 3078013 3079083 D hypothetical protein 3078013..3079083 Escherichia coli O157:H7 str. Sakai 916831 NP_311151.1 CDS glpQ NC_002695.1 3079307 3080383 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(3079307..3080383) Escherichia coli O157:H7 str. Sakai 916832 NP_311152.1 CDS glpT NC_002695.1 3080388 3081746 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(3080388..3081746) Escherichia coli O157:H7 str. Sakai 916833 NP_311153.1 CDS glpA NC_002695.1 3082019 3083647 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 3082019..3083647 Escherichia coli O157:H7 str. Sakai 916834 NP_311154.1 CDS ECs3127 NC_002695.1 3083637 3084896 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 3083637..3084896 Escherichia coli O157:H7 str. Sakai 916835 NP_311155.1 CDS glpC NC_002695.1 3084893 3086083 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 3084893..3086083 Escherichia coli O157:H7 str. Sakai 916836 NP_311156.1 CDS ECs3129 NC_002695.1 3086276 3087202 D similar to YFAD_ECOLI gi|1788577 (conserved in Escherichia coli K-12); hypothetical protein 3086276..3087202 Escherichia coli O157:H7 str. Sakai 916837 NP_311157.1 CDS ECs3130 NC_002695.1 3087243 3087995 R similar to B2245_ECOLI gi|1788578 (conserved in Escherichia coli K-12); aldolase complement(3087243..3087995) Escherichia coli O157:H7 str. Sakai 916838 NP_311158.1 CDS ECs3131 NC_002695.1 3088063 3088815 R similar to transport protein B2246_ECOLI gi|1788579; hypothetical protein complement(3088063..3088815) Escherichia coli O157:H7 str. Sakai 916839 NP_311159.1 CDS ECs3132 NC_002695.1 3088892 3089218 D OrfA protein of insertion sequence IS629; similar to hypothetical protein gi|7444868|pir||T00241; transposase 3088892..3089218 Escherichia coli O157:H7 str. Sakai 916840 NP_311160.1 CDS ECs3133 NC_002695.1 3089215 3090105 D OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 3089215..3090105 Escherichia coli O157:H7 str. Sakai 916841 NP_311161.1 CDS ECs3134 NC_002695.1 3090108 3090665 R similar to B2246_ECOLI gi|1788579; hypothetical protein complement(3090108..3090665) Escherichia coli O157:H7 str. Sakai 916842 NP_311162.1 CDS ECs3135 NC_002695.1 3090722 3091939 R similar to B2247_ECOLI gi|1788580 (conserved in Escherichia coli K-12); racemase complement(3090722..3091939) Escherichia coli O157:H7 str. Sakai 916843 NP_311163.1 CDS ECs3136 NC_002695.1 3091942 3092724 R similar to B2248_ECOLI gi|1788581 (conserved in Escherichia coli K-12); regulator complement(3091942..3092724) Escherichia coli O157:H7 str. Sakai 916844 NP_311164.1 CDS ECs3137 NC_002695.1 3092944 3094146 R similar to B2249_ECOLI gi|1788583 (conserved in Escherichia coli K-12); competence damage-inducible protein A complement(3092944..3094146) Escherichia coli O157:H7 str. Sakai 916845 NP_311165.2 CDS ECs3138 NC_002695.1 3094246 3094788 R similar to B2250_ECOLI gi|1788584 (conserved in Escherichia coli K-12); hypothetical protein complement(3094246..3094788) Escherichia coli O157:H7 str. Sakai 916846 NP_311166.1 CDS ECs3139 NC_002695.1 3095067 3095492 D similar to YFAO_ECOLI gi|1788585 (conserved in Escherichia coli K-12); hypothetical protein 3095067..3095492 Escherichia coli O157:H7 str. Sakai 916847 NP_311167.1 CDS ECs3140 NC_002695.1 3095531 3096133 R similar to AIS_ECOLI gi|1788586 (conserved in Escherichia coli K-12); aluminum-inducible protein complement(3095531..3096133) Escherichia coli O157:H7 str. Sakai 916848 NP_311168.3 CDS ECs3141 NC_002695.1 3096441 3097580 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 3096441..3097580 Escherichia coli O157:H7 str. Sakai 916849 NP_311169.1 CDS ECs3142 NC_002695.1 3097584 3098552 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 3097584..3098552 Escherichia coli O157:H7 str. Sakai 916850 NP_311170.1 CDS ECs3143 NC_002695.1 3098552 3100534 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 3098552..3100534 Escherichia coli O157:H7 str. Sakai 916851 NP_311171.1 CDS ECs3144 NC_002695.1 3100531 3101421 D similar to B2256_ECOLI gi|1788590 (conserved in Escherichia coli K-12); hypothetical protein 3100531..3101421 Escherichia coli O157:H7 str. Sakai 916852 NP_311172.1 CDS arnT NC_002695.1 3101421 3103073 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 3101421..3103073 Escherichia coli O157:H7 str. Sakai 916853 NP_944555.1 CDS ECs5486 NC_002695.1 3103070 3103405 D hypothetical protein 3103070..3103405 Escherichia coli O157:H7 str. Sakai 2693830 NP_311173.2 CDS ECs3146 NC_002695.1 3103405 3103791 D similar to B2258_ECOLI gi|1788592 (conserved in Escherichia coli K-12); hypothetical protein 3103405..3103791 Escherichia coli O157:H7 str. Sakai 916854 NP_311174.1 CDS ECs3147 NC_002695.1 3103785 3104081 R similar to PMRD_ECOLI gi|1788593 (conserved in Escherichia coli K-12); polymyxin resistance protein B complement(3103785..3104081) Escherichia coli O157:H7 str. Sakai 916855 NP_311175.1 CDS ECs3148 NC_002695.1 3104161 3105516 R similar to MENE_ECOLI gi|1788595 (conserved in Escherichia coli K-12); O-succinylbenzoic acid--CoA ligase complement(3104161..3105516) Escherichia coli O157:H7 str. Sakai 916856 NP_311176.1 CDS ECs3149 NC_002695.1 3105513 3106475 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(3105513..3106475) Escherichia coli O157:H7 str. Sakai 916857 NP_311177.1 CDS ECs3150 NC_002695.1 3106475 3107332 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(3106475..3107332) Escherichia coli O157:H7 str. Sakai 916858 NP_311178.1 CDS ECs3151 NC_002695.1 3107347 3108105 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase complement(3107347..3108105) Escherichia coli O157:H7 str. Sakai 916859 NP_311179.1 CDS ECs3152 NC_002695.1 3108102 3109772 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(3108102..3109772) Escherichia coli O157:H7 str. Sakai 916860 NP_311180.2 CDS ECs3153 NC_002695.1 3109861 3111156 R synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase complement(3109861..3111156) Escherichia coli O157:H7 str. Sakai 916861 NP_311181.1 CDS ECs3154 NC_002695.1 3111235 3111540 R similar to ELAB_ECOLI gi|1788601 (conserved in Escherichia coli K-12); hypothetical protein complement(3111235..3111540) Escherichia coli O157:H7 str. Sakai 916862 NP_311182.1 CDS ECs3155 NC_002695.1 3111595 3112056 R similar to ELAA_ECOLI gi|1788602 (conserved in Escherichia coli K-12); hypothetical protein complement(3111595..3112056) Escherichia coli O157:H7 str. Sakai 916863 NP_311183.2 CDS ECs3156 NC_002695.1 3112121 3113038 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 3112121..3113038 Escherichia coli O157:H7 str. Sakai 916864 NP_311184.1 CDS ECs3157 NC_002695.1 3113226 3114449 D ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 3113226..3114449 Escherichia coli O157:H7 str. Sakai 916865 NP_311185.1 CDS ECs3158 NC_002695.1 3115098 3115478 D similar to aminopeptidase YFBL_ECOLI gi|1788607; hypothetical protein 3115098..3115478 Escherichia coli O157:H7 str. Sakai 916866 NP_311186.1 CDS ECs3159 NC_002695.1 3115581 3116084 D similar to YFBM_ECOLI gi|1788608 (conserved in Escherichia coli K-12); hypothetical protein 3115581..3116084 Escherichia coli O157:H7 str. Sakai 916867 NP_311187.2 CDS ECs3160 NC_002695.1 3116151 3117608 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(3116151..3117608) Escherichia coli O157:H7 str. Sakai 916868 NP_311188.1 CDS ECs3161 NC_002695.1 3117615 3119144 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(3117615..3119144) Escherichia coli O157:H7 str. Sakai 916869 NP_311189.1 CDS ECs3162 NC_002695.1 3119375 3121216 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(3119375..3121216) Escherichia coli O157:H7 str. Sakai 916870 NP_311190.1 CDS ECs3163 NC_002695.1 3121213 3121515 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(3121213..3121515) Escherichia coli O157:H7 str. Sakai 916871 NP_311191.1 CDS ECs3164 NC_002695.1 3121512 3122066 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(3121512..3122066) Escherichia coli O157:H7 str. Sakai 916872 NP_311192.1 CDS ECs3165 NC_002695.1 3122078 3122620 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(3122078..3122620) Escherichia coli O157:H7 str. Sakai 916873 NP_311193.1 CDS ECs3166 NC_002695.1 3122635 3123612 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(3122635..3123612) Escherichia coli O157:H7 str. Sakai 916874 NP_311194.2 CDS ECs3167 NC_002695.1 3123609 3126335 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(3123609..3126335) Escherichia coli O157:H7 str. Sakai 916875 NP_311195.1 CDS ECs3168 NC_002695.1 3126388 3127725 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(3126388..3127725) Escherichia coli O157:H7 str. Sakai 916876 NP_311196.1 CDS ECs3169 NC_002695.1 3127722 3128222 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(3127722..3128222) Escherichia coli O157:H7 str. Sakai 916877 NP_311197.1 CDS ECs3170 NC_002695.1 3128225 3130027 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(3128225..3130027) Escherichia coli O157:H7 str. Sakai 916878 NP_311198.1 CDS ECs3171 NC_002695.1 3130121 3130783 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(3130121..3130783) Escherichia coli O157:H7 str. Sakai 916879 NP_311199.2 CDS ECs3172 NC_002695.1 3130799 3131236 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(3130799..3131236) Escherichia coli O157:H7 str. Sakai 916880 NP_311200.1 CDS ECs3173 NC_002695.1 3131873 3132811 R similar to LRHA_ECOLI gi|1788626 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(3131873..3132811) Escherichia coli O157:H7 str. Sakai 916881 NP_311201.1 CDS ECs3174 NC_002695.1 3133731 3134948 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 3133731..3134948 Escherichia coli O157:H7 str. Sakai 916882 NP_311202.1 CDS ECs3175 NC_002695.1 3135032 3135631 D similar to B2291_ECOLI gi|1788628 (conserved in Escherichia coli K-12); hypothetical protein 3135032..3135631 Escherichia coli O157:H7 str. Sakai 916883 NP_311203.1 CDS ECs3176 NC_002695.1 3135690 3137522 R similar to YFBS_ECOLI gi|1788629 (conserved in Escherichia coli K-12); transporter complement(3135690..3137522) Escherichia coli O157:H7 str. Sakai 916884 NP_311204.1 CDS ECs3177 NC_002695.1 3137609 3138259 R similar to YFBT_ECOLI gi|1788630 (conserved in Escherichia coli K-12); phosphatase complement(3137609..3138259) Escherichia coli O157:H7 str. Sakai 916885 NP_311205.2 CDS ECs3178 NC_002695.1 3138270 3138764 R similar to B2294_ECOLI gi|1788631 (conserved in Escherichia coli K-12); hypothetical protein complement(3138270..3138764) Escherichia coli O157:H7 str. Sakai 916886 NP_311206.1 CDS ECs3179 NC_002695.1 3138980 3139303 R similar to N-terminal part of B2295_ECOLI gi|1788632 (conserved in Escherichia coli K-12); hypothetical protein complement(3138980..3139303) Escherichia coli O157:H7 str. Sakai 916887 NP_311207.1 CDS ECs3180 NC_002695.1 3139641 3140843 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 3139641..3140843 Escherichia coli O157:H7 str. Sakai 916888 NP_311208.1 CDS ECs3181 NC_002695.1 3140918 3143062 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 3140918..3143062 Escherichia coli O157:H7 str. Sakai 916889 NP_311209.2 CDS ECs3182 NC_002695.1 3143252 3144772 D similar to YFCC_ECOLI gi|1788636 (conserved in Escherichia coli K-12); hypothetical protein 3143252..3144772 Escherichia coli O157:H7 str. Sakai 916890 NP_311210.1 CDS ECs3183 NC_002695.1 3144805 3145347 R similar to B2299_ECOLI gi|1788637 (conserved in Escherichia coli K-12); regulator complement(3144805..3145347) Escherichia coli O157:H7 str. Sakai 916891 NP_311211.2 CDS ECs3184 NC_002695.1 3145405 3145956 R similar to YFCE_ECOLI gi|1788638 (conserved in Escherichia coli K-12); phosphodiesterase complement(3145405..3145956) Escherichia coli O157:H7 str. Sakai 916892 NP_311212.1 CDS ECs3185 NC_002695.1 3146012 3146656 R similar to YFCF_ECOLI gi|1788639 (conserved in Escherichia coli K-12); hypothetical protein complement(3146012..3146656) Escherichia coli O157:H7 str. Sakai 916893 NP_311213.1 CDS ECs3186 NC_002695.1 3146792 3147439 D similar to YFCG_ECOLI gi|1788640 (conserved in Escherichia coli K-12); glutathione S-transferase 3146792..3147439 Escherichia coli O157:H7 str. Sakai 916894 NP_311214.1 CDS folX NC_002695.1 3147496 3147858 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 3147496..3147858 Escherichia coli O157:H7 str. Sakai 916895 NP_311215.1 CDS ECs3188 NC_002695.1 3147879 3148772 D similar to B2304_ECOLI gi|1788642 (conserved in Escherichia coli K-12); sugar nucleotide epimerase 3147879..3148772 Escherichia coli O157:H7 str. Sakai 916896 NP_311216.1 CDS ECs3189 NC_002695.1 3148820 3149710 R similar to YFCI_ECOLI gi|1788643 (conserved in Escherichia coli K-12); hypothetical protein complement(3148820..3149710) Escherichia coli O157:H7 str. Sakai 916897 NP_311217.1 CDS ECs3190 NC_002695.1 3149907 3150680 R similar to HISP_ECOLI gi|1788644 (conserved in Escherichia coli K-12); histidine/lysine/arginine/ornithine transporter subunit complement(3149907..3150680) Escherichia coli O157:H7 str. Sakai 916898 NP_311218.1 CDS ECs3191 NC_002695.1 3150688 3151404 R similar to HISM_ECOLI gi|1788645 (conserved in Escherichia coli K-12); histidine transport system membrane protein M complement(3150688..3151404) Escherichia coli O157:H7 str. Sakai 916899 NP_311219.1 CDS ECs3192 NC_002695.1 3151401 3152087 R similar to HISQ_ECOLI gi|1788646 (conserved in Escherichia coli K-12); histidine transport system permease complement(3151401..3152087) Escherichia coli O157:H7 str. Sakai 916900 NP_311220.1 CDS ECs3193 NC_002695.1 3152177 3152959 R similar to HISJ_ECOLI gi|1788648 (conserved in Escherichia coli K-12); histidine transport system histidine-binding periplasmic protein complement(3152177..3152959) Escherichia coli O157:H7 str. Sakai 916901 NP_311221.1 CDS ECs3194 NC_002695.1 3153180 3153962 R similar to ARGT_ECOLI gi|1788649 (conserved in Escherichia coli K-12); lysine-, arginine-, ornithine-binding periplasmic protein complement(3153180..3153962) Escherichia coli O157:H7 str. Sakai 916902 NP_311222.1 CDS ECs3195 NC_002695.1 3154228 3154797 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(3154228..3154797) Escherichia coli O157:H7 str. Sakai 916903 NP_311223.1 CDS ECs3196 NC_002695.1 3154892 3156409 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(3154892..3156409) Escherichia coli O157:H7 str. Sakai 916904 NP_311224.1 CDS ECs3197 NC_002695.1 3156446 3156934 R membrane protein required for colicin V production; colicin V production protein complement(3156446..3156934) Escherichia coli O157:H7 str. Sakai 916905 NP_311225.2 CDS ECs3198 NC_002695.1 3157375 3158037 R similar to DEDD_ECOLI gi|1788653 (conserved in Escherichia coli K-12); hypothetical protein complement(3157375..3158037) Escherichia coli O157:H7 str. Sakai 916906 NP_311226.1 CDS ECs3199 NC_002695.1 3158027 3159295 R similar to FOLC_ECOLI gi|1788654 (conserved in Escherichia coli K-12); bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(3158027..3159295) Escherichia coli O157:H7 str. Sakai 916907 NP_311227.1 CDS ECs3200 NC_002695.1 3159365 3160279 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(3159365..3160279) Escherichia coli O157:H7 str. Sakai 916908 NP_311228.1 CDS ECs3201 NC_002695.1 3160435 3161094 R similar to DEDA_ECOLI gi|1788656 (conserved in Escherichia coli K-12); hypothetical protein complement(3160435..3161094) Escherichia coli O157:H7 str. Sakai 917121 NP_311229.1 CDS truA NC_002695.1 3161177 3161989 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(3161177..3161989) Escherichia coli O157:H7 str. Sakai 912282 NP_311230.1 CDS ECs3203 NC_002695.1 3161989 3163002 R similar to USG_ECOLI gi|1788658 (conserved in Escherichia coli K-12); semialdehyde dehydrogenase complement(3161989..3163002) Escherichia coli O157:H7 str. Sakai 915699 NP_311231.1 CDS ECs3204 NC_002695.1 3163068 3164204 R catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate; erythronate-4-phosphate dehydrogenase complement(3163068..3164204) Escherichia coli O157:H7 str. Sakai 915698 NP_311232.1 CDS flk NC_002695.1 3164303 3165298 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 3164303..3165298 Escherichia coli O157:H7 str. Sakai 915697 NP_311233.1 CDS ECs3206 NC_002695.1 3165295 3166473 R similar to B2322_ECOLI gi|1788662 (conserved in Escherichia coli K-12); hypothetical protein complement(3165295..3166473) Escherichia coli O157:H7 str. Sakai 915695 NP_944556.1 CDS ECs5487 NC_002695.1 3166415 3166636 D hypothetical protein 3166415..3166636 Escherichia coli O157:H7 str. Sakai 2693831 NP_311234.1 CDS ECs3207 NC_002695.1 3166748 3167968 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase complement(3166748..3167968) Escherichia coli O157:H7 str. Sakai 915694 NP_311235.2 CDS mnmC NC_002695.1 3168127 3170133 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 3168127..3170133 Escherichia coli O157:H7 str. Sakai 913957 NP_311236.1 CDS ECs3209 NC_002695.1 3170254 3170532 R similar to B2325_ECOLI gi|1788665 (conserved in Escherichia coli K-12); hypothetical protein complement(3170254..3170532) Escherichia coli O157:H7 str. Sakai 917120 NP_311237.1 CDS ECs3210 NC_002695.1 3170566 3171114 R similar to B2326_ECOLI gi|1788666 (conserved in Escherichia coli K-12); transporting ATPase complement(3170566..3171114) Escherichia coli O157:H7 str. Sakai 915494 NP_311238.1 CDS ECs3211 NC_002695.1 3171114 3171923 R similar to YFCA_ECOLI gi|1788667 (conserved in Escherichia coli K-12); hypothetical protein complement(3171114..3171923) Escherichia coli O157:H7 str. Sakai 915693 NP_311239.1 CDS mepA NC_002695.1 3171923 3172747 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(3171923..3172747) Escherichia coli O157:H7 str. Sakai 915692 NP_311240.1 CDS ECs3213 NC_002695.1 3172751 3173836 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(3172751..3173836) Escherichia coli O157:H7 str. Sakai 915691 NP_311241.2 CDS ECs3215 NC_002695.1 3173871 3174803 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(3173871..3174803) Escherichia coli O157:H7 str. Sakai 915690 NP_311242.1 CDS ECs3214 NC_002695.1 3174969 3175520 D similar to B2331_ECOLI gi|1788671 (conserved in Escherichia coli K-12); hypothetical protein 3174969..3175520 Escherichia coli O157:H7 str. Sakai 915689 NP_311243.1 CDS ECs3216 NC_002695.1 3175691 3176533 R similar to B2332_ECOLI gi|7466328|pir||B65006; hypothetical protein complement(3175691..3176533) Escherichia coli O157:H7 str. Sakai 915688 NP_311244.1 CDS ECs3217 NC_002695.1 3176535 3177083 R similar to B2333_ECOLI gi1788674, minor fimbrial subunit StfG protein [Salmonella typhimurium] dad|AF093503-7|AAC64157.1; fimbrial-like protein complement(3176535..3177083) Escherichia coli O157:H7 str. Sakai 915687 NP_311245.1 CDS ECs3218 NC_002695.1 3177053 3177523 R similar to B2334_ECOLI gi|1788675, minor fimbrial subunits e.g. StfF [Salmonella typhimurium] gi3747033; fimbrial protein complement(3177053..3177523) Escherichia coli O157:H7 str. Sakai 915686 NP_311246.1 CDS ECs3219 NC_002695.1 3177520 3178020 R similar to B2335_ECOLI gi|1788676, minor fimbrial subunit StfE protein [Salmonella typhimurium] dad|AF093503-5|AAC64155.1; fimbrial protein complement(3177520..3178020) Escherichia coli O157:H7 str. Sakai 915685 NP_311247.1 CDS ECs3220 NC_002695.1 3178031 3178789 R similar to YFCS_ECOLI gi|1788677, periplasmic fimbrial chaperone StfD protein [Salmonella typhimurium] dad|AF093503-4|AAC64154.1; chaperone complement(3178031..3178789) Escherichia coli O157:H7 str. Sakai 915684 NP_311248.1 CDS ECs3221 NC_002695.1 3178812 3181451 R similar to YFCU_ECOLI gi|1788679, B2337_ECOLI gi|1788678; outer membrane protein complement(3178812..3181451) Escherichia coli O157:H7 str. Sakai 915682 NP_311249.1 CDS ECs3222 NC_002695.1 3181533 3182096 R similar to B2339_ECOLI gi|1788680, major fimbrial subunit StfA protein [Salmonella typhimurium ] dad|AF093503-2|AAC64152.1; fimbrial-like protein complement(3181533..3182096) Escherichia coli O157:H7 str. Sakai 915681 NP_311250.1 CDS ECs3223 NC_002695.1 3182742 3183227 R similar to B2340_ECOLI gi|1788681 (conserved in Escherichia coli K-12); phosphohistidine phosphatase complement(3182742..3183227) Escherichia coli O157:H7 str. Sakai 915680 NP_311251.1 CDS fadJ NC_002695.1 3183430 3185574 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(3183430..3185574) Escherichia coli O157:H7 str. Sakai 915679 NP_311252.1 CDS fadI NC_002695.1 3185574 3186884 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(3185574..3186884) Escherichia coli O157:H7 str. Sakai 915678 NP_311253.2 CDS ECs3226 NC_002695.1 3187064 3187348 R similar to B2343_ECOLI gi|1788685 (conserved in Escherichia coli K-12); hypothetical protein complement(3187064..3187348) Escherichia coli O157:H7 str. Sakai 915677 NP_311254.1 CDS ECs3227 NC_002695.1 3187714 3189060 D similar to FADL_ECOLI gi|1788686 (conserved in Escherichia coli K-12); long-chain fatty acid outer membrane transporter 3187714..3189060 Escherichia coli O157:H7 str. Sakai 915676 NP_311255.1 CDS ECs3228 NC_002695.1 3189425 3190456 D similar to B2345_ECOLI gi|1788687; hypothetical protein 3189425..3190456 Escherichia coli O157:H7 str. Sakai 915675 NP_311256.1 CDS ECs3229 NC_002695.1 3190851 3191606 R similar to VACJ_ECOLI gi|1788688 (conserved in Escherichia coli K-12); lipoprotein precursor complement(3190851..3191606) Escherichia coli O157:H7 str. Sakai 915674 NP_311257.1 CDS ECs3230 NC_002695.1 3191900 3192832 D similar to YFDC_ECOLI gi|1788689 (conserved in Escherichia coli K-12); transport 3191900..3192832 Escherichia coli O157:H7 str. Sakai 915673 NP_311258.1 CDS ECs3231 NC_002695.1 3193144 3194301 D similar to INTC_ECOLI gi|1788690 (conserved in Escherichia coli K-12); prophage Sf6-like integrase 3193144..3194301 Escherichia coli O157:H7 str. Sakai 915670 NP_311259.1 CDS ECs3232 NC_002695.1 3194476 3195612 R similar to DNA injection protein gp20 [phage P22] gi|1174950|sp|Q01076|VG20_BPP22; DNA injection protein complement(3194476..3195612) Escherichia coli O157:H7 str. Sakai 915669 NP_311260.1 CDS ECs3233 NC_002695.1 3195622 3196302 R similar to DNA transfer protein Gp7 [Bacteriophage P22] gi|418222|sp|Q01074|VG07_BPP22; DNA transfer protein complement(3195622..3196302) Escherichia coli O157:H7 str. Sakai 915668 NP_311261.1 CDS ECs3234 NC_002695.1 3196289 3196756 R similar to hypothetical protein P31 [Bacteriophage APSE-1] gi|6118026|gb|AAF03974.1|AF157835_31, gp14 [Bacteriophage P22] gi|418225|sp|Q01075|VG14_BPP22; hypothetical protein complement(3196289..3196756) Escherichia coli O157:H7 str. Sakai 915667 NP_311262.1 CDS ECs3235 NC_002695.1 3196756 3197043 R hypothetical protein complement(3196756..3197043) Escherichia coli O157:H7 str. Sakai 915666 NP_311263.1 CDS ECs3236 NC_002695.1 3197308 3198003 D similar to replication proteins e.g. [Haemophilus actinomycetemcomitans Plasmid pVT736-1] gi|398106|gb|AAC37125.1|; replication protein 3197308..3198003 Escherichia coli O157:H7 str. Sakai 915665 NP_311265.1 CDS ECs3238 NC_002695.1 3198673 3200085 R hypothetical protein complement(3198673..3200085) Escherichia coli O157:H7 str. Sakai 915663 NP_311266.1 CDS ECs3239 NC_002695.1 3200272 3200448 R hypothetical protein complement(3200272..3200448) Escherichia coli O157:H7 str. Sakai 915661 NP_311267.1 CDS ECs3240 NC_002695.1 3200751 3201377 D similar to resolvases e.g. [Plasmid pM3] gi|5668998|gb|AAD46124.1|AF078924_3, [Yersinia pestis plasmid pMT1] gi|7467461|pir||T14990; resolvase 3200751..3201377 Escherichia coli O157:H7 str. Sakai 915660 NP_311268.1 CDS lacY NC_002695.1 3201975 3203222 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(3201975..3203222) Escherichia coli O157:H7 str. Sakai 915659 NP_311269.1 CDS ECs3242 NC_002695.1 3203294 3204208 R phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase complement(3203294..3204208) Escherichia coli O157:H7 str. Sakai 915658 NP_311270.1 CDS ECs3243 NC_002695.1 3204424 3205857 D similar to sucrose hydrolase [Escherichia coli strain EC3132] gi|3462879|gb|AAC33123.1; sucrose-6 phosphate hydrolase 3204424..3205857 Escherichia coli O157:H7 str. Sakai 915657 NP_311271.1 CDS ECs3244 NC_002695.1 3205865 3206860 R similar to sucrose operon repressor [Escherichia coli] gi|729214|sp|P40715|CSCR_ECOLI; sucrose operon repressor complement(3205865..3206860) Escherichia coli O157:H7 str. Sakai 915656 NP_311272.1 CDS ECs3245 NC_002695.1 3207339 3208667 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 3207339..3208667 Escherichia coli O157:H7 str. Sakai 915655 NP_311273.1 CDS ECs3246 NC_002695.1 3208775 3210313 R similar to EMRY_ECOLI gi|1788710 (conserved in Escherichia coli K-12); multidrug resistance protein Y complement(3208775..3210313) Escherichia coli O157:H7 str. Sakai 915654 NP_311274.1 CDS ECs3247 NC_002695.1 3210313 3211476 R similar to EMRK_ECOLI gi|1788711 (conserved in Escherichia coli K-12); multidrug resistance protein K complement(3210313..3211476) Escherichia coli O157:H7 str. Sakai 915653 NP_311275.1 CDS ECs3248 NC_002695.1 3211892 3212506 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; EvgA family transcriptional regulator 3211892..3212506 Escherichia coli O157:H7 str. Sakai 915651 NP_311276.1 CDS ECs3249 NC_002695.1 3212511 3216104 D similar to EVGS_ECOLI gi|1788713 (conserved in Escherichia coli K-12); EvgA family transcriptional regulator 3212511..3216104 Escherichia coli O157:H7 str. Sakai 915650 NP_311277.1 CDS ECs3250 NC_002695.1 3216160 3217086 R similar to YFDE_ECOLI gi|1788714; hypothetical protein complement(3216160..3217086) Escherichia coli O157:H7 str. Sakai 915649 NP_311278.1 CDS ECs3251 NC_002695.1 3217071 3217301 R similar to YFDE_ECOLI gi|1788714; hypothetical protein complement(3217071..3217301) Escherichia coli O157:H7 str. Sakai 915648 NP_311279.1 CDS ECs3252 NC_002695.1 3217375 3218319 R member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV complement(3217375..3218319) Escherichia coli O157:H7 str. Sakai 915647 NP_311280.1 CDS ECs3253 NC_002695.1 3218389 3220083 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(3218389..3220083) Escherichia coli O157:H7 str. Sakai 915646 NP_311281.1 CDS ECs3254 NC_002695.1 3220137 3221387 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(3220137..3221387) Escherichia coli O157:H7 str. Sakai 915645 NP_311282.1 CDS ECs3255 NC_002695.1 3221900 3222535 R similar to B2375_ECOLI gi|1788719 (conserved in Escherichia coli K-12); hypothetical protein complement(3221900..3222535) Escherichia coli O157:H7 str. Sakai 915644 NP_311283.1 CDS ECs3256 NC_002695.1 3222831 3223106 D similar to B2376_ECOLI gi|2367134 (conserved in Escherichia coli K-12); hypothetical protein 3222831..3223106 Escherichia coli O157:H7 str. Sakai 915642 NP_311284.1 CDS ECs3257 NC_002695.1 3223183 3223425 R similar to B2377_ECOLI gi|1788720 (conserved in Escherichia coli K-12); hypothetical protein complement(3223183..3223425) Escherichia coli O157:H7 str. Sakai 915641 NP_311285.2 CDS ECs3258 NC_002695.1 3223778 3224698 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 3223778..3224698 Escherichia coli O157:H7 str. Sakai 915640 NP_311286.1 CDS ECs3259 NC_002695.1 3225190 3226428 R similar to B2379_ECOLI gi|1788722 (conserved in Escherichia coli K-12); aminotransferase complement(3225190..3226428) Escherichia coli O157:H7 str. Sakai 915639 NP_311287.1 CDS ECs3260 NC_002695.1 3226805 3228502 D similar to B2380_ECOLI gi|1788723 (conserved in Escherichia coli K-12); sensor protein 3226805..3228502 Escherichia coli O157:H7 str. Sakai 915638 NP_311288.1 CDS ECs3261 NC_002695.1 3228517 3229251 D similar to B2381_ECOLI gi|1788724 (conserved in Escherichia coli K-12); 2-component transcriptional regulator 3228517..3229251 Escherichia coli O157:H7 str. Sakai 915637 NP_311289.1 CDS ECs3262 NC_002695.1 3229264 3230121 D similar to B2382_ECOLI gi|1788725 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 3229264..3230121 Escherichia coli O157:H7 str. Sakai 915636 NP_311290.1 CDS ECs3263 NC_002695.1 3230124 3232619 R similar to B2383_ECOLI gi|1788726 (conserved in Escherichia coli K-12); PTS system enzyme IIA component complement(3230124..3232619) Escherichia coli O157:H7 str. Sakai 915635 NP_311291.1 CDS ECs3264 NC_002695.1 3232644 3233681 R metalloprotein; exoaminopeptidase complement(3232644..3233681) Escherichia coli O157:H7 str. Sakai 915634 NP_311292.1 CDS ECs3265 NC_002695.1 3233681 3234766 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(3233681..3234766) Escherichia coli O157:H7 str. Sakai 915633 NP_311293.1 CDS ECs3266 NC_002695.1 3234781 3236028 R similar to B2386_ECOLI gi|1788729 (conserved in Escherichia coli K-12); transporter complement(3234781..3236028) Escherichia coli O157:H7 str. Sakai 915632 NP_311294.1 CDS ECs3267 NC_002695.1 3236050 3236376 R similar to B2387_ECOLI gi|1788730 (conserved in Escherichia coli K-12); PTS system enzyme IIB component complement(3236050..3236376) Escherichia coli O157:H7 str. Sakai 915630 NP_311295.1 CDS glk NC_002695.1 3236595 3237560 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(3236595..3237560) Escherichia coli O157:H7 str. Sakai 915629 NP_311296.1 CDS ECs3269 NC_002695.1 3237764 3239020 D similar to B2389_ECOLI gi|1788733 (conserved in Escherichia coli K-12); hypothetical protein 3237764..3239020 Escherichia coli O157:H7 str. Sakai 915628 NP_311297.1 CDS ECs3270 NC_002695.1 3239135 3239461 D similar to B2390_ECOLI gi|1788734 (conserved in Escherichia coli K-12); hypothetical protein 3239135..3239461 Escherichia coli O157:H7 str. Sakai 915627 NP_311298.1 CDS ECs3271 NC_002695.1 3239601 3240839 R similar to B2392_ECOLI (MntH) gi|1788736|sp|P77145 (conserved in Escherichia coli K-12); manganese transport protein MntH complement(3239601..3240839) Escherichia coli O157:H7 str. Sakai 915626 NP_311299.1 CDS ECs3272 NC_002695.1 3241175 3242377 D similar to NUPC_ECOLI gi|1788737 (conserved in Escherichia coli K-12); permease of transport system for 3 nucleosides 3241175..3242377 Escherichia coli O157:H7 str. Sakai 915625 NP_311300.1 CDS ECs3273 NC_002695.1 3242427 3244616 R similar to YFEA_ECOLI gi|1788739 (conserved in Escherichia coli K-12); hypothetical protein complement(3242427..3244616) Escherichia coli O157:H7 str. Sakai 915624 NP_311301.1 CDS ECs3274 NC_002695.1 3245235 3245594 D similar to YFEC_ECOLI gi|1788741 (conserved in Escherichia coli K-12); hypothetical protein 3245235..3245594 Escherichia coli O157:H7 str. Sakai 915618 NP_311302.1 CDS ECs3275 NC_002695.1 3245596 3245988 D similar to YFED_ECOLI gi|1788742 (conserved in Escherichia coli K-12); hypothetical protein 3245596..3245988 Escherichia coli O157:H7 str. Sakai 915613 NP_311303.2 CDS ECs3276 NC_002695.1 3246028 3247236 R similar to EryA homologue [Bacteriophage If1] dad|U02303-9|AAC62159.1; hypothetical protein complement(3246028..3247236) Escherichia coli O157:H7 str. Sakai 915607 NP_311304.1 CDS ECs3277 NC_002695.1 3247244 3247786 D similar to transposase homolog A [Helicobacter pylori] gi|2114470|gb|AAD11513.1; transposase TnA 3247244..3247786 Escherichia coli O157:H7 str. Sakai 915604 NP_311305.1 CDS gltX NC_002695.1 3247787 3249202 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(3247787..3249202) Escherichia coli O157:H7 str. Sakai 915601 NP_311306.1 CDS ECs3279 NC_002695.1 3249977 3250318 D similar to FLXA_ECOLI gi|2498386|sp|P77609; hypothetical protein 3249977..3250318 Escherichia coli O157:H7 str. Sakai 915572 NP_311307.1 CDS ECs3280 NC_002695.1 3250309 3250659 R similar to transcriptional regulator YFER_ECOLI gi|1788748; may contain frameshift; hypothetical protein complement(3250309..3250659) Escherichia coli O157:H7 str. Sakai 915567 NP_311308.1 CDS ECs3281 NC_002695.1 3250681 3251235 R similar to transcriptional regulator YFER_ECOLI gi|1788748; may contain frameshift; hypothetical protein complement(3250681..3251235) Escherichia coli O157:H7 str. Sakai 915566 NP_311309.1 CDS ECs3282 NC_002695.1 3251325 3252323 D similar to YFEH_ECOLI gi|1788749 (conserved in Escherichia coli K-12); cytochrome oxidase 3251325..3252323 Escherichia coli O157:H7 str. Sakai 915563 NP_944557.1 CDS ECs5495 NC_002695.1 3252320 3252538 R hypothetical protein complement(3252320..3252538) Escherichia coli O157:H7 str. Sakai 2693824 NP_311310.1 CDS ligA NC_002695.1 3252540 3254555 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(3252540..3254555) Escherichia coli O157:H7 str. Sakai 915555 NP_311311.1 CDS ECs3284 NC_002695.1 3254626 3255624 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(3254626..3255624) Escherichia coli O157:H7 str. Sakai 915552 NP_311312.1 CDS ECs3285 NC_002695.1 3255854 3256615 D role in sulfur assimilation; sulfate transport protein CysZ 3255854..3256615 Escherichia coli O157:H7 str. Sakai 915545 NP_311313.1 CDS ECs3286 NC_002695.1 3256800 3257771 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 3256800..3257771 Escherichia coli O157:H7 str. Sakai 915544 NP_311314.1 CDS ECs3287 NC_002695.1 3258155 3258412 D similar to PTSH_ECOLI gi|1788755 (conserved in Escherichia coli K-12); PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 3258155..3258412 Escherichia coli O157:H7 str. Sakai 915540 NP_311315.1 CDS ECs3288 NC_002695.1 3258457 3260184 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 3258457..3260184 Escherichia coli O157:H7 str. Sakai 915537 NP_311316.1 CDS ECs3289 NC_002695.1 3260225 3260734 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 3260225..3260734 Escherichia coli O157:H7 str. Sakai 915535 NP_311317.1 CDS pdxK NC_002695.1 3260777 3261628 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(3260777..3261628) Escherichia coli O157:H7 str. Sakai 915526 NP_311318.1 CDS ECs3291 NC_002695.1 3261733 3262065 D similar to YFEK_ECOLI gi|1788759; hypothetical protein 3261733..3262065 Escherichia coli O157:H7 str. Sakai 915519 NP_311319.1 CDS cysM NC_002695.1 3262103 3263014 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(3262103..3263014) Escherichia coli O157:H7 str. Sakai 915515 NP_311320.1 CDS ECs3293 NC_002695.1 3263148 3264245 R similar to CYSA_ECOLI gi|1788761 (conserved in Escherichia coli K-12); sulfate/thiosulfate transporter subunit complement(3263148..3264245) Escherichia coli O157:H7 str. Sakai 915512 NP_311321.2 CDS cysW NC_002695.1 3264235 3265110 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease complement(3264235..3265110) Escherichia coli O157:H7 str. Sakai 915509 NP_311322.1 CDS ECs3295 NC_002695.1 3265110 3265943 R similar to CYSU_ECOLI gi|1788764 (conserved in Escherichia coli K-12); sulfate/thiosulfate transporter subunit complement(3265110..3265943) Escherichia coli O157:H7 str. Sakai 915499 NP_311323.1 CDS ECs3296 NC_002695.1 3265943 3266959 R similar to CYSP_ECOLI gi|1788765 (conserved in Escherichia coli K-12); thiosulfate transporter subunit complement(3265943..3266959) Escherichia coli O157:H7 str. Sakai 915491 NP_311324.2 CDS ECs3297 NC_002695.1 3267117 3267908 R similar to UCPA_ECOLI gi|1788766 (conserved in Escherichia coli K-12); short chain dehydrogenase complement(3267117..3267908) Escherichia coli O157:H7 str. Sakai 915487 NP_311325.1 CDS ECs3298 NC_002695.1 3268037 3268894 R similar to YFET_ECOLI gi|1788767 (conserved in Escherichia coli K-12); hypothetical protein complement(3268037..3268894) Escherichia coli O157:H7 str. Sakai 915484 NP_311326.1 CDS murQ NC_002695.1 3269058 3269954 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 3269058..3269954 Escherichia coli O157:H7 str. Sakai 915479 NP_311327.1 CDS murP NC_002695.1 3269958 3271382 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 3269958..3271382 Escherichia coli O157:H7 str. Sakai 915478 NP_311328.1 CDS ECs3301 NC_002695.1 3271387 3272691 D similar to beta-lactamase B2430_ECOLI gi|1788770 (conserved in Escherichia coli K-12); hypothetical protein 3271387..3272691 Escherichia coli O157:H7 str. Sakai 915366 NP_311329.2 CDS ECs3302 NC_002695.1 3272749 3273648 R similar to B2431_ECOLI gi|1788771 (conserved in Escherichia coli K-12); hypothetical protein complement(3272749..3273648) Escherichia coli O157:H7 str. Sakai 915365 NP_311330.1 CDS ECs3303 NC_002695.1 3273744 3274319 R similar to B2432_ECOLI gi|1788772 (conserved in Escherichia coli K-12); hypothetical protein complement(3273744..3274319) Escherichia coli O157:H7 str. Sakai 915362 NP_311331.2 CDS ECs3304 NC_002695.1 3274380 3274829 R similar to B2433_ECOLI gi|1788773 (conserved in Escherichia coli K-12); hypothetical protein complement(3274380..3274829) Escherichia coli O157:H7 str. Sakai 915306 NP_311332.2 CDS ECs3305 NC_002695.1 3274816 3275241 R similar to B2434_ECOLI gi|1788774 (conserved in Escherichia coli K-12); acetyltransferase complement(3274816..3275241) Escherichia coli O157:H7 str. Sakai 915305 NP_311333.1 CDS ECs3306 NC_002695.1 3275455 3276324 D similar to AMIA_ECOLI gi|1788776 (conserved in Escherichia coli K-12); N-acetylmuramoyl-l-alanine amidase I 3275455..3276324 Escherichia coli O157:H7 str. Sakai 915304 NP_311334.1 CDS ECs3307 NC_002695.1 3276328 3277227 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 3276328..3277227 Escherichia coli O157:H7 str. Sakai 915300 NP_311335.1 CDS ECs3308 NC_002695.1 3277233 3278285 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(3277233..3278285) Escherichia coli O157:H7 str. Sakai 915299 NP_311336.2 CDS ECs3309 NC_002695.1 3278331 3278831 R similar to B2438_ECOLI gi|1788779 (conserved in Escherichia coli K-12); hypothetical protein complement(3278331..3278831) Escherichia coli O157:H7 str. Sakai 915298 NP_311337.1 CDS ECs3310 NC_002695.1 3278844 3279503 R similar to B2439_ECOLI gi|1788780 (conserved in Escherichia coli K-12); hypothetical protein complement(3278844..3279503) Escherichia coli O157:H7 str. Sakai 915297 NP_311338.1 CDS ECs3311 NC_002695.1 3279513 3280400 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(3279513..3280400) Escherichia coli O157:H7 str. Sakai 915296 NP_311339.1 CDS ECs3312 NC_002695.1 3280421 3281782 R similar to EUTB_ECOLI gi|1788782 (conserved in Escherichia coli K-12); ethanolamine ammonia-lyase heavy chain complement(3280421..3281782) Escherichia coli O157:H7 str. Sakai 915295 NP_311340.1 CDS eutA NC_002695.1 3281794 3283197 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(3281794..3283197) Escherichia coli O157:H7 str. Sakai 915292 NP_311341.1 CDS ECs3314 NC_002695.1 3283194 3284420 R similar to EUTH_ECOLI gi|1788794 (conserved in Escherichia coli K-12); ethanolamine utilization protein; EutH complement(3283194..3284420) Escherichia coli O157:H7 str. Sakai 915290 NP_311342.2 CDS ECs3315 NC_002695.1 3284520 3285707 R similar to EUTG_ECOLI gi|1788795 (conserved in Escherichia coli K-12); hypothetical protein complement(3284520..3285707) Escherichia coli O157:H7 str. Sakai 915288 NP_311343.1 CDS ECs3316 NC_002695.1 3285697 3286533 R similar to EUTJ_ECOLI gi|1788796 (conserved in Escherichia coli K-12); ethanolamine utilization protein; EutJ complement(3285697..3286533) Escherichia coli O157:H7 str. Sakai 915284 NP_311344.1 CDS ECs3317 NC_002695.1 3286544 3287947 R similar to EUTE_ECOLI gi|1788797 (conserved in Escherichia coli K-12); ethanolamine utilization protein; EutE complement(3286544..3287947) Escherichia coli O157:H7 str. Sakai 915281 NP_311345.1 CDS ECs3318 NC_002695.1 3287959 3288246 R similar to CCHB_ECOLI gi|1788798 (conserved in Escherichia coli K-12); detox protein complement(3287959..3288246) Escherichia coli O157:H7 str. Sakai 915280 NP_311346.2 CDS ECs3319 NC_002695.1 3288353 3288646 R similar to CCHA_ECOLI gi|1788799 (conserved in Escherichia coli K-12); detox protein complement(3288353..3288646) Escherichia coli O157:H7 str. Sakai 915278 NP_311347.1 CDS eutD NC_002695.1 3288685 3289701 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(3288685..3289701) Escherichia coli O157:H7 str. Sakai 915277 NP_311348.1 CDS ECs3321 NC_002695.1 3289698 3290429 R similar to B2459_ECOLI gi|1788801 (conserved in Escherichia coli K-12); hypothetical protein complement(3289698..3290429) Escherichia coli O157:H7 str. Sakai 915276 NP_311349.1 CDS ECs3322 NC_002695.1 3290426 3291127 R similar to B2460_ECOLI gi|1788802 (conserved in Escherichia coli K-12); ethanolamine utilization protein EutQ complement(3290426..3291127) Escherichia coli O157:H7 str. Sakai 915275 NP_311350.1 CDS ECs3323 NC_002695.1 3291102 3291581 R similar to B2461_ECOLI gi|1788803 (conserved in Escherichia coli K-12); hypothetical protein complement(3291102..3291581) Escherichia coli O157:H7 str. Sakai 913769 NP_311351.2 CDS ECs3324 NC_002695.1 3291594 3291929 R similar to B2462_ECOLI gi|1788804 (conserved in Escherichia coli K-12); hypothetical protein complement(3291594..3291929) Escherichia coli O157:H7 str. Sakai 917116 NP_311352.1 CDS ECs3325 NC_002695.1 3292222 3294501 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(3292222..3294501) Escherichia coli O157:H7 str. Sakai 915273 NP_311353.1 CDS ECs3326 NC_002695.1 3294790 3295740 D Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase A 3294790..3295740 Escherichia coli O157:H7 str. Sakai 915272 NP_311354.1 CDS ECs3327 NC_002695.1 3295760 3297763 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3295760..3297763 Escherichia coli O157:H7 str. Sakai 917137 NP_311355.1 CDS ECs3328 NC_002695.1 3297858 3298901 R similar to B2466_ECOLI gi|1788809 (conserved in Escherichia coli K-12); hypothetical protein complement(3297858..3298901) Escherichia coli O157:H7 str. Sakai 912782 NP_311356.1 CDS ECs3329 NC_002695.1 3299027 3299602 R similar to YFFH_ECOLI gi|1788810 (conserved in Escherichia coli K-12); hypothetical protein complement(3299027..3299602) Escherichia coli O157:H7 str. Sakai 917127 NP_311357.1 CDS ECs3330 NC_002695.1 3299670 3301649 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(3299670..3301649) Escherichia coli O157:H7 str. Sakai 912413 NP_311358.1 CDS ECs3331 NC_002695.1 3301855 3303555 D similar to NARQ_ECOLI gi|1788812 (conserved in Escherichia coli K-12); nitrate/nitrite sensor protein NarQ 3301855..3303555 Escherichia coli O157:H7 str. Sakai 915268 NP_311359.1 CDS ECs3332 NC_002695.1 3303719 3306832 D similar to ACRD_ECOLI gi|1788814 (conserved in Escherichia coli K-12); aminoglycoside/multidrug efflux system 3303719..3306832 Escherichia coli O157:H7 str. Sakai 915267 NP_311360.1 CDS ECs3333 NC_002695.1 3307371 3307727 D similar to YFFB_ECOLI gi|1788815 (conserved in Escherichia coli K-12); hypothetical protein 3307371..3307727 Escherichia coli O157:H7 str. Sakai 915265 NP_311361.1 CDS ECs3334 NC_002695.1 3307731 3308858 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 3307731..3308858 Escherichia coli O157:H7 str. Sakai 915264 NP_944558.1 CDS ECs5496 NC_002695.1 3308886 3309086 D hypothetical protein 3308886..3309086 Escherichia coli O157:H7 str. Sakai 2693833 NP_311362.2 CDS ECs3335 NC_002695.1 3309167 3309865 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase complement(3309167..3309865) Escherichia coli O157:H7 str. Sakai 915263 NP_311363.1 CDS ECs3336 NC_002695.1 3309939 3311954 R similar to YPFI_ECOLI gi|1788818 (conserved in Escherichia coli K-12); hypothetical protein complement(3309939..3311954) Escherichia coli O157:H7 str. Sakai 915260 NP_311364.1 CDS ECs3337 NC_002695.1 3311969 3312832 R similar to B2475_ECOLI gi|1788819 (conserved in Escherichia coli K-12); hypothetical protein complement(3311969..3312832) Escherichia coli O157:H7 str. Sakai 915256 NP_311365.1 CDS ECs3338 NC_002695.1 3313000 3313713 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(3313000..3313713) Escherichia coli O157:H7 str. Sakai 915199 NP_311366.2 CDS ECs3339 NC_002695.1 3313926 3314960 R similar to NLPB_ECOLI gi|1788822 (conserved in Escherichia coli K-12); lipoprotein complement(3313926..3314960) Escherichia coli O157:H7 str. Sakai 915254 NP_311367.1 CDS dapA NC_002695.1 3314977 3315855 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(3314977..3315855) Escherichia coli O157:H7 str. Sakai 915253 NP_311368.2 CDS gcvR NC_002695.1 3316001 3316573 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 3316001..3316573 Escherichia coli O157:H7 str. Sakai 915250 NP_311369.1 CDS bcp NC_002695.1 3316573 3317043 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 3316573..3317043 Escherichia coli O157:H7 str. Sakai 915247 NP_311370.2 CDS ECs3343 NC_002695.1 3317296 3317913 D similar to HYFA_ECOLI gi|1788826 (conserved in Escherichia coli K-12); hydrogenase 4 Fe-S subunit 3317296..3317913 Escherichia coli O157:H7 str. Sakai 915246 NP_311371.1 CDS ECs3344 NC_002695.1 3317913 3319931 D Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit B 3317913..3319931 Escherichia coli O157:H7 str. Sakai 915245 NP_311372.2 CDS ECs3345 NC_002695.1 3319942 3320889 D similar to HYFC_ECOLI gi|1788828 (conserved in Escherichia coli K-12); hydrogenase 4 membrane subunit 3319942..3320889 Escherichia coli O157:H7 str. Sakai 915244 NP_311373.1 CDS ECs3346 NC_002695.1 3320906 3322345 D similar to HYFD_ECOLI gi|1788829 (conserved in Escherichia coli K-12); hydrogenase 4 subunit D 3320906..3322345 Escherichia coli O157:H7 str. Sakai 915242 NP_311374.1 CDS hyfE NC_002695.1 3322357 3323007 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 3322357..3323007 Escherichia coli O157:H7 str. Sakai 915241 NP_311375.1 CDS ECs3348 NC_002695.1 3323012 3324592 D Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit F 3323012..3324592 Escherichia coli O157:H7 str. Sakai 915239 NP_311376.1 CDS ECs3349 NC_002695.1 3324582 3326297 D similar to HYFG_ECOLI gi|1788832; hydrogenase 4 subunit 3324582..3326297 Escherichia coli O157:H7 str. Sakai 915238 NP_311377.1 CDS ECs3350 NC_002695.1 3326307 3326852 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 3326307..3326852 Escherichia coli O157:H7 str. Sakai 915237 NP_311378.1 CDS ECs3351 NC_002695.1 3326849 3327607 D similar to HYFI_ECOLI gi|1788834 (conserved in Escherichia coli K-12); hydrogenase 4 Fe-S subunit 3326849..3327607 Escherichia coli O157:H7 str. Sakai 915236 NP_311379.1 CDS ECs3352 NC_002695.1 3327537 3328013 D similar to B2490_ECOLI gi|1788835 (conserved in Escherichia coli K-12); protein processing element 3327537..3328013 Escherichia coli O157:H7 str. Sakai 915234 NP_311380.2 CDS ECs3353 NC_002695.1 3328043 3330055 D similar to HYFR_ECOLI gi|1788836 (conserved in Escherichia coli K-12); 2-component regulator 3328043..3330055 Escherichia coli O157:H7 str. Sakai 915230 NP_311381.1 CDS focB NC_002695.1 3330077 3330925 D inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 3330077..3330925 Escherichia coli O157:H7 str. Sakai 915229 NP_311382.1 CDS ECs3355 NC_002695.1 3330963 3332024 R similar to PERM_ECOLI gi|1788838 (conserved in Escherichia coli K-12); permease complement(3330963..3332024) Escherichia coli O157:H7 str. Sakai 915228 NP_311383.1 CDS ECs3356 NC_002695.1 3332237 3333700 D similar to B2494_ECOLI gi|1788840 (conserved in Escherichia coli K-12); hypothetical protein 3332237..3333700 Escherichia coli O157:H7 str. Sakai 915227 NP_311384.1 CDS ECs3357 NC_002695.1 3333721 3334080 D similar to B2495_ECOLI gi|1788841 (conserved in Escherichia coli K-12); oxidoreductase 3333721..3334080 Escherichia coli O157:H7 str. Sakai 913850 NP_311385.1 CDS ECs3358 NC_002695.1 3334218 3334964 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(3334218..3334964) Escherichia coli O157:H7 str. Sakai 917118 NP_311386.1 CDS ECs3359 NC_002695.1 3335014 3336303 R similar to URAA_ECOLI gi|1788843 (conserved in Escherichia coli K-12); uracil transporter complement(3335014..3336303) Escherichia coli O157:H7 str. Sakai 915224 NP_311387.2 CDS upp NC_002695.1 3336389 3337015 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(3336389..3337015) Escherichia coli O157:H7 str. Sakai 915222 NP_311388.1 CDS ECs3361 NC_002695.1 3337340 3338377 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 3337340..3338377 Escherichia coli O157:H7 str. Sakai 915220 NP_311389.1 CDS purN NC_002695.1 3338377 3339015 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 3338377..3339015 Escherichia coli O157:H7 str. Sakai 917133 NP_311390.1 CDS ECs3363 NC_002695.1 3339186 3341252 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3339186..3341252 Escherichia coli O157:H7 str. Sakai 912733 NP_311391.1 CDS ECs3364 NC_002695.1 3341257 3342798 D similar to PPX_ECOLI gi|1788848 (conserved in Escherichia coli K-12); exopolyphosphatase 3341257..3342798 Escherichia coli O157:H7 str. Sakai 914211 NP_311392.1 CDS ECs3365 NC_002695.1 3342837 3345080 R similar to B2503_ECOLI gi|1788849 (conserved in Escherichia coli K-12); cytochrome C-type biogenesis protein complement(3342837..3345080) Escherichia coli O157:H7 str. Sakai 913938 NP_944559.1 CDS ECs5497 NC_002695.1 3345262 3345414 R hypothetical protein complement(3345262..3345414) Escherichia coli O157:H7 str. Sakai 2693759 NP_311393.1 CDS ECs3366 NC_002695.1 3345432 3345623 D similar to B2504_ECOLI gi|1788851 (conserved in Escherichia coli K-12); hypothetical protein 3345432..3345623 Escherichia coli O157:H7 str. Sakai 915219 NP_311394.1 CDS ECs3367 NC_002695.1 3345934 3346452 D similar to B2505_ECOLI gi|1788852 (conserved in Escherichia coli K-12); outer membrane lipoprotein 3345934..3346452 Escherichia coli O157:H7 str. Sakai 915218 NP_311395.1 CDS ECs3368 NC_002695.1 3346468 3347007 D similar to B2506_ECOLI gi|1788853 (conserved in Escherichia coli K-12); hypothetical protein 3346468..3347007 Escherichia coli O157:H7 str. Sakai 915262 NP_311396.1 CDS guaA NC_002695.1 3347100 3348677 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(3347100..3348677) Escherichia coli O157:H7 str. Sakai 912290 NP_311397.1 CDS ECs3370 NC_002695.1 3348746 3350212 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(3348746..3350212) Escherichia coli O157:H7 str. Sakai 917779 NP_311398.1 CDS xseA NC_002695.1 3350374 3351744 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 3350374..3351744 Escherichia coli O157:H7 str. Sakai 912353 NP_311399.1 CDS ECs3372 NC_002695.1 3351741 3351956 R similar to B2510_ECOLI gi|1788857 (conserved in Escherichia coli K-12); hypothetical protein complement(3351741..3351956) Escherichia coli O157:H7 str. Sakai 915216 NP_311400.2 CDS engA NC_002695.1 3352025 3353497 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(3352025..3353497) Escherichia coli O157:H7 str. Sakai 915214 NP_311401.1 CDS ECs3374 NC_002695.1 3353615 3354793 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(3353615..3354793) Escherichia coli O157:H7 str. Sakai 915213 NP_311402.1 CDS ECs3375 NC_002695.1 3354804 3355424 R similar to B2513_ECOLI gi|1788860 (conserved in Escherichia coli K-12); hypothetical protein complement(3354804..3355424) Escherichia coli O157:H7 str. Sakai 915212 NP_311403.1 CDS hisS NC_002695.1 3355442 3356716 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(3355442..3356716) Escherichia coli O157:H7 str. Sakai 915211 NP_311404.1 CDS ispG NC_002695.1 3356827 3357945 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(3356827..3357945) Escherichia coli O157:H7 str. Sakai 915209 NP_311405.1 CDS ECs3378 NC_002695.1 3357972 3358985 R similar to YFGA_ECOLI gi|1788864 (conserved in Escherichia coli K-12); cytoskeletal protein RodZ complement(3357972..3358985) Escherichia coli O157:H7 str. Sakai 915208 NP_311406.1 CDS ECs3379 NC_002695.1 3359270 3360424 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(3359270..3360424) Escherichia coli O157:H7 str. Sakai 915207 NP_311407.1 CDS ndk NC_002695.1 3360574 3361005 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(3360574..3361005) Escherichia coli O157:H7 str. Sakai 915205 NP_311408.1 CDS ECs3381 NC_002695.1 3361146 3362000 R similar to ferredoxin [Methanosarcina thermophila] gi|282643|pir||A42960, polyferredoxin [Methanococcus voltae] gi|99156|pir||S24802; polyferredoxin complement(3361146..3362000) Escherichia coli O157:H7 str. Sakai 915204 NP_311409.1 CDS ECs3382 NC_002695.1 3362000 3362821 R similar to anaerobic dimethyl sulfoxide reductase chain C e.g. [Escherichia coli] gi|118699|sp|P18777|DMSC_ECOLI; anaerobic dimethyl sulfoxide reductase chain C complement(3362000..3362821) Escherichia coli O157:H7 str. Sakai 915203 NP_311410.1 CDS ECs3383 NC_002695.1 3362814 3363443 R similar to anaerobic dimethyl sulfoxide reductases chain B e.g. [Escherichia coli] gi|2506394|sp|P18776|DMSB_ECOLI; anaerobic dimethyl sulfoxide reductase subunit B complement(3362814..3363443) Escherichia coli O157:H7 str. Sakai 917134 NP_311411.1 CDS ECs3384 NC_002695.1 3363440 3365821 R similar to anaerobic dimethyl sulfoxide reductase chain A precursors e.g. [Escherichia coli] gi|118697|sp|P18775|DMSA_ECOLI; anaerobic dimethyl sulfoxide reductase subunit A complement(3363440..3365821) Escherichia coli O157:H7 str. Sakai 912748 NP_311412.1 CDS ECs3385 NC_002695.1 3365985 3368297 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(3365985..3368297) Escherichia coli O157:H7 str. Sakai 912842 NP_311413.1 CDS ECs3386 NC_002695.1 3368298 3373259 R similar to B2520_ECOLI gi|1788868 (conserved in Escherichia coli K-12); hypothetical protein complement(3368298..3373259) Escherichia coli O157:H7 str. Sakai 912952 NP_311414.2 CDS sseA NC_002695.1 3373466 3374311 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 3373466..3374311 Escherichia coli O157:H7 str. Sakai 915202 NP_311415.2 CDS ECs3388 NC_002695.1 3374811 3375587 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(3374811..3375587) Escherichia coli O157:H7 str. Sakai 917135 NP_311416.2 CDS ECs3389 NC_002695.1 3375730 3377013 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase complement(3375730..3377013) Escherichia coli O157:H7 str. Sakai 912754 NP_311417.1 CDS ECs3390 NC_002695.1 3377191 3377391 R similar to YFHJ_ECOLI gi|1788873 (conserved in Escherichia coli K-12); hypothetical protein complement(3377191..3377391) Escherichia coli O157:H7 str. Sakai 913777 NP_311418.1 CDS ECs3391 NC_002695.1 3377403 3377738 R similar to FER_ECOLI gi|119999|sp|P25528 (conserved in Escherichia coli K-12); [2FE-2S] ferredoxin complement(3377403..3377738) Escherichia coli O157:H7 str. Sakai 917117 NP_311419.1 CDS hscA NC_002695.1 3377740 3379590 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(3377740..3379590) Escherichia coli O157:H7 str. Sakai 915196 NP_311420.1 CDS hscB NC_002695.1 3379607 3380122 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(3379607..3380122) Escherichia coli O157:H7 str. Sakai 915200 NP_311421.1 CDS iscA NC_002695.1 3380218 3380541 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(3380218..3380541) Escherichia coli O157:H7 str. Sakai 915168 NP_311422.1 CDS ECs3395 NC_002695.1 3380558 3380944 R similar to ISCU_ECOLI gi|7387937|sp|P77310 (conserved in Escherichia coli K-12); scaffold protein complement(3380558..3380944) Escherichia coli O157:H7 str. Sakai 915163 NP_311423.2 CDS ECs3396 NC_002695.1 3380972 3382186 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(3380972..3382186) Escherichia coli O157:H7 str. Sakai 915161 NP_311424.1 CDS ECs3397 NC_002695.1 3382298 3382786 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(3382298..3382786) Escherichia coli O157:H7 str. Sakai 915159 NP_311425.1 CDS ECs3398 NC_002695.1 3383087 3383824 R similar to B2532_ECOLI (YhfQ) gi|1788881 (conserved in Escherichia coli K-12); ATP synthase subunit beta complement(3383087..3383824) Escherichia coli O157:H7 str. Sakai 915158 NP_311426.1 CDS ECs3399 NC_002695.1 3383943 3384746 D similar to SUHB_ECOLI gi|1788882 (conserved in Escherichia coli K-12); inositol monophosphatase 3383943..3384746 Escherichia coli O157:H7 str. Sakai 915157 NP_311427.2 CDS ECs3400 NC_002695.1 3384891 3385745 D similar to B2534_ECOLI gi|1788884 (conserved in Escherichia coli K-12); hypothetical protein 3384891..3385745 Escherichia coli O157:H7 str. Sakai 915154 NP_311428.2 CDS ECs3401 NC_002695.1 3385936 3387216 D similar to CSIE_ECOLI gi|1788885 (conserved in Escherichia coli K-12); stationary phase inducible protein CsiE 3385936..3387216 Escherichia coli O157:H7 str. Sakai 915085 NP_311429.1 CDS ECs3402 NC_002695.1 3387208 3388347 R transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(3387208..3388347) Escherichia coli O157:H7 str. Sakai 915038 NP_311430.1 CDS ECs3403 NC_002695.1 3388507 3389397 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(3388507..3389397) Escherichia coli O157:H7 str. Sakai 914136 NP_311431.1 CDS ECs3404 NC_002695.1 3389533 3390894 D similar to HCAA1_ECOLI gi|1788888 (conserved in Escherichia coli K-12); phenylpropionate dioxygenase large terminal subunit 3389533..3390894 Escherichia coli O157:H7 str. Sakai 913881 NP_311432.1 CDS ECs3405 NC_002695.1 3390891 3391409 D similar to HCAA2_ECOLI gi|1788889 (conserved in Escherichia coli K-12); 3-phenylpropionate dioxygenase subunit beta 3390891..3391409 Escherichia coli O157:H7 str. Sakai 914927 NP_311433.1 CDS ECs3406 NC_002695.1 3391409 3391729 D similar to HCAC_ECOLI gi|1788890 (conserved in Escherichia coli K-12); 3-phenylpropionate dioxygenase ferredoxin subunit 3391409..3391729 Escherichia coli O157:H7 str. Sakai 914928 NP_311434.1 CDS ECs3407 NC_002695.1 3391726 3392538 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 3391726..3392538 Escherichia coli O157:H7 str. Sakai 914919 NP_311435.1 CDS ECs3408 NC_002695.1 3392548 3393750 D similar to HCAD_ECOLI gi|1788892 (conserved in Escherichia coli K-12); phenylpropionate dioxygenase ferredoxin reductase subunit 3392548..3393750 Escherichia coli O157:H7 str. Sakai 914925 NP_311436.2 CDS ECs3409 NC_002695.1 3393847 3394269 D similar to YPHA_ECOLI gi|1788893 (conserved in Escherichia coli K-12); hypothetical protein 3393847..3394269 Escherichia coli O157:H7 str. Sakai 914923 NP_311437.1 CDS ECs3410 NC_002695.1 3394317 3395189 R similar to YPHB_ECOLI gi|1788894 (conserved in Escherichia coli K-12); hypothetical protein complement(3394317..3395189) Escherichia coli O157:H7 str. Sakai 914921 NP_311438.1 CDS ECs3411 NC_002695.1 3395201 3395989 R similar to YPHC_ECOLI gi|1788895; hypothetical protein complement(3395201..3395989) Escherichia coli O157:H7 str. Sakai 914924 NP_944560.1 CDS ECs5498 NC_002695.1 3396071 3396295 R hypothetical protein complement(3396071..3396295) Escherichia coli O157:H7 str. Sakai 2693756 NP_311439.1 CDS ECs3412 NC_002695.1 3396328 3397326 R similar to YPHD_ECOLI gi|1788896 (conserved in Escherichia coli K-12); transport system permease complement(3396328..3397326) Escherichia coli O157:H7 str. Sakai 914920 NP_311440.1 CDS ECs3413 NC_002695.1 3397351 3398862 R similar to YPHE_ECOLI gi|1788897 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(3397351..3398862) Escherichia coli O157:H7 str. Sakai 914917 NP_311441.1 CDS ECs3414 NC_002695.1 3398885 3399868 R similar to YPHF_ECOLI gi|1788898 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator complement(3398885..3399868) Escherichia coli O157:H7 str. Sakai 914918 NP_311442.1 CDS ECs3415 NC_002695.1 3399965 3403339 R similar to YPHG_ECOLI gi|1788900 (conserved in Escherichia coli K-12); hypothetical protein complement(3399965..3403339) Escherichia coli O157:H7 str. Sakai 914914 NP_311443.2 CDS ECs3416 NC_002695.1 3403364 3404557 D similar to YPHH_ECOLI gi|1788901 (conserved in Escherichia coli K-12); NAGC-like transcriptional regulator 3403364..3404557 Escherichia coli O157:H7 str. Sakai 914916 NP_311444.1 CDS glyA NC_002695.1 3404620 3405873 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(3404620..3405873) Escherichia coli O157:H7 str. Sakai 914911 NP_311445.1 CDS ECs3418 NC_002695.1 3406201 3407391 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 3406201..3407391 Escherichia coli O157:H7 str. Sakai 914915 NP_311446.1 CDS ECs3419 NC_002695.1 3407436 3407774 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(3407436..3407774) Escherichia coli O157:H7 str. Sakai 914897 NP_311447.1 CDS ECs3420 NC_002695.1 3407835 3409169 R similar to YFHA_ECOLI gi|1788905 (conserved in Escherichia coli K-12); 2-component transcriptional regulator complement(3407835..3409169) Escherichia coli O157:H7 str. Sakai 914905 NP_311448.1 CDS ECs3421 NC_002695.1 3409159 3409872 R similar to YFHG_ECOLI gi|1788906 (conserved in Escherichia coli K-12); hypothetical protein complement(3409159..3409872) Escherichia coli O157:H7 str. Sakai 914899 NP_311449.1 CDS ECs3422 NC_002695.1 3410037 3411527 R similar to YFHK_ECOLI gi|1788908 (conserved in Escherichia coli K-12); 2-component sensor protein complement(3410037..3411527) Escherichia coli O157:H7 str. Sakai 914903 NP_311450.1 CDS ECs3423 NC_002695.1 3412040 3415927 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(3412040..3415927) Escherichia coli O157:H7 str. Sakai 914912 NP_311451.1 CDS ECs3424 NC_002695.1 3416322 3417740 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 3416322..3417740 Escherichia coli O157:H7 str. Sakai 914913 NP_311452.1 CDS ECs3425 NC_002695.1 3417737 3418273 R similar to YFHC_ECOLI gi|1788911 (conserved in Escherichia coli K-12); tRNA-specific adenosine deaminase complement(3417737..3418273) Escherichia coli O157:H7 str. Sakai 914909 NP_311453.2 CDS ECs3426 NC_002695.1 3418298 3418933 R similar to YFHB_ECOLI gi|1788912 (conserved in Escherichia coli K-12); hypothetical protein complement(3418298..3418933) Escherichia coli O157:H7 str. Sakai 914902 NP_311454.2 CDS ECs3427 NC_002695.1 3419142 3419990 D similar to YFHH_ECOLI gi|1788913 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 3419142..3419990 Escherichia coli O157:H7 str. Sakai 914910 NP_311455.1 CDS ECs3428 NC_002695.1 3420046 3420306 D similar to YFHL_ECOLI gi|1788914 (conserved in Escherichia coli K-12); hypothetical protein 3420046..3420306 Escherichia coli O157:H7 str. Sakai 914901 NP_311456.1 CDS acpS NC_002695.1 3421002 3421382 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(3421002..3421382) Escherichia coli O157:H7 str. Sakai 914898 NP_311457.1 CDS ECs3430 NC_002695.1 3421382 3422113 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(3421382..3422113) Escherichia coli O157:H7 str. Sakai 914900 NP_311458.1 CDS recO NC_002695.1 3422125 3422853 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(3422125..3422853) Escherichia coli O157:H7 str. Sakai 914896 NP_311459.1 CDS era NC_002695.1 3422865 3423770 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(3422865..3423770) Escherichia coli O157:H7 str. Sakai 914890 NP_311460.1 CDS rnc NC_002695.1 3423767 3424447 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(3423767..3424447) Escherichia coli O157:H7 str. Sakai 914894 NP_311461.1 CDS ECs3434 NC_002695.1 3424720 3425694 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(3424720..3425694) Escherichia coli O157:H7 str. Sakai 914889 NP_311462.1 CDS ECs3435 NC_002695.1 3425710 3427509 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(3425710..3427509) Escherichia coli O157:H7 str. Sakai 915772 NP_311463.1 CDS ECs3436 NC_002695.1 3427707 3428186 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(3427707..3428186) Escherichia coli O157:H7 str. Sakai 914892 NP_311464.1 CDS rseB NC_002695.1 3428183 3429139 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(3428183..3429139) Escherichia coli O157:H7 str. Sakai 914893 NP_311465.1 CDS ECs3438 NC_002695.1 3429139 3429777 R similar to RSEA_ECOLI gi|1788925 (conserved in Escherichia coli K-12); anti-RNA polymerase sigma factor SigE complement(3429139..3429777) Escherichia coli O157:H7 str. Sakai 914891 NP_311466.1 CDS ECs3439 NC_002695.1 3429810 3430385 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(3429810..3430385) Escherichia coli O157:H7 str. Sakai 914887 NP_311467.1 CDS ECs3440 NC_002695.1 3430793 3432415 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 3430793..3432415 Escherichia coli O157:H7 str. Sakai 914886 NP_311468.1 CDS ECs3441 NC_002695.1 3432400 3433257 R similar to YFIC_ECOLI gi|1788929 (conserved in Escherichia coli K-12); hypothetical protein complement(3432400..3433257) Escherichia coli O157:H7 str. Sakai 914885 NP_311469.1 CDS ECs3442 NC_002695.1 3433269 3434603 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 3433269..3434603 Escherichia coli O157:H7 str. Sakai 914884 NP_311470.2 CDS ECs3443 NC_002695.1 3434636 3435517 R similar to YFIE_ECOLI gi|1788931 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(3434636..3435517) Escherichia coli O157:H7 str. Sakai 914883 NP_311471.1 CDS ECs3444 NC_002695.1 3435620 3436207 D similar to YFIK_ECOLI gi|1788932 (conserved in Escherichia coli K-12); neutral amino-acid efflux protein 3435620..3436207 Escherichia coli O157:H7 str. Sakai 914882 NP_311472.1 CDS ECs3445 NC_002695.1 3436263 3436646 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(3436263..3436646) Escherichia coli O157:H7 str. Sakai 914881 NP_311473.1 CDS ECs3446 NC_002695.1 3436951 3437607 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 3436951..3437607 Escherichia coli O157:H7 str. Sakai 914880 NP_311474.1 CDS ECs3447 NC_002695.1 3437689 3438726 R similar to YFIF_ECOLI gi|1788935 (conserved in Escherichia coli K-12); methyltransferase complement(3437689..3438726) Escherichia coli O157:H7 str. Sakai 914879 NP_311475.1 CDS ECs3448 NC_002695.1 3438933 3439352 D similar to TRXC_ECOLI gi|1788936 (conserved in Escherichia coli K-12); thioredoxin 2 3438933..3439352 Escherichia coli O157:H7 str. Sakai 914878 NP_311476.2 CDS ECs3449 NC_002695.1 3439421 3440119 D similar to YFIP_ECOLI gi|1788937 (conserved in Escherichia coli K-12); hypothetical protein 3439421..3440119 Escherichia coli O157:H7 str. Sakai 914877 NP_311479.2 CDS pssA NC_002695.1 3442926 3444281 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 3442926..3444281 Escherichia coli O157:H7 str. Sakai 914873 NP_311480.1 CDS ECs3453 NC_002695.1 3444378 3444650 D similar to YFIM_ECOLI gi|1788941 (conserved in Escherichia coli K-12); hypothetical protein 3444378..3444650 Escherichia coli O157:H7 str. Sakai 914872 NP_311481.1 CDS ECs3454 NC_002695.1 3444647 3445945 R similar to KGTP_ECOLI gi|1788942 (conserved in Escherichia coli K-12); alpha-ketoglutarate transporter complement(3444647..3445945) Escherichia coli O157:H7 str. Sakai 914871 NP_311482.1 CDS ECs3455 NC_002695.1 3451719 3454292 R similar to CLPB_ECOLI gi|1788943 (conserved in Escherichia coli K-12); protein disaggregation chaperone complement(3451719..3454292) Escherichia coli O157:H7 str. Sakai 914865 NP_311483.1 CDS ECs3456 NC_002695.1 3454422 3455153 R similar to YFIH_ECOLI gi|1788945 (conserved in Escherichia coli K-12); hypothetical protein complement(3454422..3455153) Escherichia coli O157:H7 str. Sakai 914864 NP_311484.1 CDS rluD NC_002695.1 3455150 3456130 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(3455150..3456130) Escherichia coli O157:H7 str. Sakai 914863 NP_311485.1 CDS ECs3458 NC_002695.1 3456265 3457002 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 3456265..3457002 Escherichia coli O157:H7 str. Sakai 914862 NP_311486.1 CDS ECs3459 NC_002695.1 3457032 3457238 D similar to B2596_ECOLI gi|1788948 (conserved in Escherichia coli K-12); hypothetical protein 3457032..3457238 Escherichia coli O157:H7 str. Sakai 914861 NP_311487.1 CDS ECs3460 NC_002695.1 3457273 3457614 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 3457273..3457614 Escherichia coli O157:H7 str. Sakai 914860 NP_311489.1 CDS pheA NC_002695.1 3457864 3459024 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 3457864..3459024 Escherichia coli O157:H7 str. Sakai 914858 NP_311490.1 CDS tyrA NC_002695.1 3459067 3460188 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(3459067..3460188) Escherichia coli O157:H7 str. Sakai 914857 NP_311491.1 CDS ECs3464 NC_002695.1 3460199 3461269 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(3460199..3461269) Escherichia coli O157:H7 str. Sakai 914856 NP_311492.1 CDS ECs3465 NC_002695.1 3461440 3461844 D similar to YFIL_ECOLI gi|1788954 (conserved in Escherichia coli K-12); hypothetical protein 3461440..3461844 Escherichia coli O157:H7 str. Sakai 914855 NP_311493.1 CDS ECs3466 NC_002695.1 3461994 3462512 D similar to B2603_ECOLI gi|1788955 (conserved in Escherichia coli K-12); hypothetical protein 3461994..3462512 Escherichia coli O157:H7 str. Sakai 914829 NP_311494.1 CDS ECs3467 NC_002695.1 3462502 3463728 D similar to YFIN_ECOLI gi|1788956 (conserved in Escherichia coli K-12); hypothetical protein 3462502..3463728 Escherichia coli O157:H7 str. Sakai 914822 NP_311495.1 CDS ECs3468 NC_002695.1 3463744 3464226 D similar to YFIB_ECOLI gi|1788957 (conserved in Escherichia coli K-12); outer membrane lipoprotein 3463744..3464226 Escherichia coli O157:H7 str. Sakai 914820 NP_311496.1 CDS rplS NC_002695.1 3464303 3464650 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(3464303..3464650) Escherichia coli O157:H7 str. Sakai 914819 NP_311497.1 CDS trmD NC_002695.1 3464692 3465459 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(3464692..3465459) Escherichia coli O157:H7 str. Sakai 914818 NP_311498.3 CDS rimM NC_002695.1 3465490 3466038 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(3465490..3466038) Escherichia coli O157:H7 str. Sakai 914817 NP_311499.1 CDS rpsP NC_002695.1 3466057 3466305 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(3466057..3466305) Escherichia coli O157:H7 str. Sakai 914816 NP_311500.1 CDS ECs3473 NC_002695.1 3466442 3467803 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(3466442..3467803) Escherichia coli O157:H7 str. Sakai 914815 NP_311501.2 CDS ECs3474 NC_002695.1 3467970 3468761 D similar to B2611_ECOLI gi|1788964 (conserved in Escherichia coli K-12); hypothetical protein 3467970..3468761 Escherichia coli O157:H7 str. Sakai 914814 NP_311502.1 CDS ECs3475 NC_002695.1 3468873 3470069 D similar to YPJE_ECOLI gi|1788965, YFJD_ECOLI gi|1788966; hypothetical protein 3468873..3470069 Escherichia coli O157:H7 str. Sakai 914813 NP_311503.1 CDS ECs3476 NC_002695.1 3470124 3470717 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(3470124..3470717) Escherichia coli O157:H7 str. Sakai 914812 NP_311504.1 CDS ppnK NC_002695.1 3470840 3471718 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3470840..3471718 Escherichia coli O157:H7 str. Sakai 914811 NP_311505.1 CDS ECs3478 NC_002695.1 3471804 3473465 D similar to RECN_ECOLI gi|1788969 (conserved in Escherichia coli K-12); recombination and repair protein 3471804..3473465 Escherichia coli O157:H7 str. Sakai 914810 NP_311506.1 CDS ECs3479 NC_002695.1 3473803 3473955 D similar to SMPA_ECOLI gi|1788970 (conserved in Escherichia coli K-12); small membrane protein A 3473803..3473955 Escherichia coli O157:H7 str. Sakai 914809 NP_311507.2 CDS ECs3480 NC_002695.1 3474017 3474307 R similar to B2618_ECOLI gi|1788971 (conserved in Escherichia coli K-12); hypothetical protein complement(3474017..3474307) Escherichia coli O157:H7 str. Sakai 914808 NP_311508.1 CDS ECs3481 NC_002695.1 3474297 3474773 R similar to B2619_ECOLI gi|1788972 (conserved in Escherichia coli K-12); hypothetical protein complement(3474297..3474773) Escherichia coli O157:H7 str. Sakai 914807 NP_311509.1 CDS smpB NC_002695.1 3474905 3475387 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3474905..3475387 Escherichia coli O157:H7 str. Sakai 914806 NP_311510.1 CDS ECs3483 NC_002695.1 3476233 3476481 D similar to DNA damage-inducible proteins e.g. DinI [Escherichia coli] gi|2498305|sp|Q47143|DINI_ECOLI; DNA damage-inducible protein 3476233..3476481 Escherichia coli O157:H7 str. Sakai 914804 NP_311512.1 CDS ECs3485 NC_002695.1 3476983 3477573 R similar to TrcA-like proteins e.g. bfpT-regulated chaperone-like protein TrcA [Escherichia coli strain B171-8] gi|4126789|dbj|BAA36747.1|; chaperone-like protein complement(3476983..3477573) Escherichia coli O157:H7 str. Sakai 914802 NP_311513.1 CDS ECs3486 NC_002695.1 3477756 3478406 D similar to hypothetical proteins e.g. ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1|; hypothetical protein 3477756..3478406 Escherichia coli O157:H7 str. Sakai 914800 NP_311514.1 CDS ECs3487 NC_002695.1 3478485 3479543 D similar to hypothetical protein ORF3 [Escherichia coli strain B171-8] gi|4126791|dbj|BAA36749.1|; hypothetical protein 3478485..3479543 Escherichia coli O157:H7 str. Sakai 914799 NP_311515.1 CDS ECs3488 NC_002695.1 3479673 3480095 R similar to hypothetical proteins e.g. ORF4 [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1|; hypothetical protein complement(3479673..3480095) Escherichia coli O157:H7 str. Sakai 914798 NP_311516.1 CDS ECs3489 NC_002695.1 3480256 3480645 R similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein complement(3480256..3480645) Escherichia coli O157:H7 str. Sakai 914797 NP_311517.1 CDS ECs3490 NC_002695.1 3480743 3481069 D OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241, hypothetical proteins of IS elements e.g. TnpE [Shigella flexneri] gi|5532454|gb|AAD44738.1|AF141323_9; transposase 3480743..3481069 Escherichia coli O157:H7 str. Sakai 914796 NP_311518.1 CDS ECs3491 NC_002695.1 3481066 3481956 D OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 3481066..3481956 Escherichia coli O157:H7 str. Sakai 914795 NP_311519.1 CDS ECs3492 NC_002695.1 3481763 3482260 R similar to hypothetical protein L0015 Escherichia coli O157:H7 strain EDL933 AAC31494; hypothetical protein complement(3481763..3482260) Escherichia coli O157:H7 str. Sakai 914794 NP_311520.1 CDS ECs3493 NC_002695.1 3482457 3482804 R similar to hypothetical protein L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1|, similar tohypothetical proteins e.g. ORF50 [Escherichia coli] gi|6009426|dbj|BAA84885.1|; hypothetical protein complement(3482457..3482804) Escherichia coli O157:H7 str. Sakai 914793 NP_311521.1 CDS ECs3494 NC_002695.1 3482801 3483181 R similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1|; hypothetical protein complement(3482801..3483181) Escherichia coli O157:H7 str. Sakai 914792 NP_311523.1 CDS ECs3496 NC_002695.1 3483538 3483882 R similar to hypothetical protein YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein complement(3483538..3483882) Escherichia coli O157:H7 str. Sakai 914790 NP_311524.1 CDS ECs3497 NC_002695.1 3483887 3484102 R host cell lysis; similar to holins e.g. [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1|; holin complement(3483887..3484102) Escherichia coli O157:H7 str. Sakai 914789 NP_311525.1 CDS ECs3498 NC_002695.1 3484252 3486105 R similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein complement(3484252..3486105) Escherichia coli O157:H7 str. Sakai 914788 NP_311526.1 CDS ECs3499 NC_002695.1 3486346 3486675 D hypothetical protein 3486346..3486675 Escherichia coli O157:H7 str. Sakai 914787 NP_311527.2 CDS ECs3500 NC_002695.1 3486766 3487482 R similar to hypothetical protein [Actinobacillus actinomycetemcomitans] gi|7592819|dbj|BAA94406.1; hypothetical protein complement(3486766..3487482) Escherichia coli O157:H7 str. Sakai 914786 NP_311528.1 CDS ECs3501 NC_002695.1 3487762 3488385 R similar to antitermination proteins e.g. protein Q [Bacteriophage lambda] gi|132278|sp|P03047|REGQ_LAMBD; antitermination protein complement(3487762..3488385) Escherichia coli O157:H7 str. Sakai 914785 NP_311529.1 CDS ECs3502 NC_002695.1 3488382 3489047 R similar to serine/threonine protein phosphatases e.g. [Bacteriophage lambda] gi|130792|sp|P03772|PP_LAMBD; serine/threonine protein phosphatase complement(3488382..3489047) Escherichia coli O157:H7 str. Sakai 914783 NP_311530.1 CDS ECs3503 NC_002695.1 3489044 3489655 R similar to hypothetical proteins e.g. NinG [Bacteriophage 21] gi|4539482|emb|CAB39991.1|; hypothetical protein complement(3489044..3489655) Escherichia coli O157:H7 str. Sakai 914782 NP_311531.1 CDS ECs3504 NC_002695.1 3489630 3490196 R similar to phage hypothetical proteins e.g. [Bacteriophage phi-YeO3-12] gi|6598993|emb|CAB63597.1|; hypothetical protein complement(3489630..3490196) Escherichia coli O157:H7 str. Sakai 914781 NP_311533.1 CDS ECs3506 NC_002695.1 3491224 3491619 D lipoprotein 3491224..3491619 Escherichia coli O157:H7 str. Sakai 914779 NP_311534.1 CDS ECs3507 NC_002695.1 3491695 3492963 R hypothetical protein complement(3491695..3492963) Escherichia coli O157:H7 str. Sakai 914778 NP_311535.1 CDS ECs3508 NC_002695.1 3493359 3493772 R hypothetical protein complement(3493359..3493772) Escherichia coli O157:H7 str. Sakai 914777 NP_311536.1 CDS ECs3509 NC_002695.1 3493870 3494268 R hypothetical protein complement(3493870..3494268) Escherichia coli O157:H7 str. Sakai 914776 NP_311537.1 CDS ECs3510 NC_002695.1 3494269 3495900 R similar to ctp synthase - Rickettsia prowasekii C71695, hypothetical protein Plasmodium falciparum CAB39033; hypothetical protein complement(3494269..3495900) Escherichia coli O157:H7 str. Sakai 914775 NP_311538.1 CDS ECs3511 NC_002695.1 3495897 3497210 R hypothetical protein complement(3495897..3497210) Escherichia coli O157:H7 str. Sakai 914774 NP_311539.1 CDS ECs3512 NC_002695.1 3497212 3498417 R probable integrase; similar to site specific recombinases e.g. integrase-recombinase [Methanobacterium thermoautotrophicum] gi|7428936|pir||D69219; site specific recombinase complement(3497212..3498417) Escherichia coli O157:H7 str. Sakai 914773 NP_311540.1 CDS ECs3513 NC_002695.1 3498740 3498946 R similar to Bacteriophage P4 DNA-binding protein P12552 and Yersinia pestis hypothetical protein T17447; DNA binding protein complement(3498740..3498946) Escherichia coli O157:H7 str. Sakai 914772 NP_311541.1 CDS ECs3514 NC_002695.1 3499046 3499897 R hypothetical protein complement(3499046..3499897) Escherichia coli O157:H7 str. Sakai 914771 NP_311542.1 CDS ECs3515 NC_002695.1 3500324 3505039 R similar to YPJA_ECOLI gi|1789001 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(3500324..3505039) Escherichia coli O157:H7 str. Sakai 914770 NP_311544.1 CDS ECs3517 NC_002695.1 3505846 3507195 R similar to B2650_ECOLI gi|1789004, B2649_ECOLI gi|1789003; hypothetical protein complement(3505846..3507195) Escherichia coli O157:H7 str. Sakai 914768 NP_311545.1 CDS ECs3518 NC_002695.1 3508583 3509821 D similar to B2654_ECOLI gi|1789007, B2655_ECOLI similar to gi|1789008; hypothetical protein 3508583..3509821 Escherichia coli O157:H7 str. Sakai 914766 NP_311546.1 CDS ECs3519 NC_002695.1 3509828 3510835 D similar to B2657_ECOLI gi|1789010, B2658_ECOLI gi|1789012; hypothetical protein 3509828..3510835 Escherichia coli O157:H7 str. Sakai 914765 NP_311547.2 CDS ECs3520 NC_002695.1 3511172 3512149 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3511172..3512149 Escherichia coli O157:H7 str. Sakai 914764 NP_311548.1 CDS ECs3521 NC_002695.1 3512103 3513437 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3512103..3513437 Escherichia coli O157:H7 str. Sakai 914763 NP_311549.1 CDS gabD NC_002695.1 3513460 3514908 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3513460..3514908 Escherichia coli O157:H7 str. Sakai 914762 NP_311550.1 CDS ECs3523 NC_002695.1 3514922 3516202 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3514922..3516202 Escherichia coli O157:H7 str. Sakai 914761 NP_311551.1 CDS ECs3524 NC_002695.1 3516440 3517840 D similar to GABP_ECOLI gi|1789017 (conserved in Escherichia coli K-12); gamma-aminobutyrate transporter 3516440..3517840 Escherichia coli O157:H7 str. Sakai 914760 NP_311552.2 CDS ECs3525 NC_002695.1 3517861 3518523 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3517861..3518523 Escherichia coli O157:H7 str. Sakai 914759 NP_311553.1 CDS ECs3526 NC_002695.1 3518524 3518973 R similar to YGAU_ECOLI gi|1789019 (conserved in Escherichia coli K-12); LysM domain/BON superfamily protein complement(3518524..3518973) Escherichia coli O157:H7 str. Sakai 914758 NP_311554.1 CDS ECs3527 NC_002695.1 3519057 3519215 R similar to B2666_ECOLI gi|1789020 (conserved in Escherichia coli K-12); hypothetical protein complement(3519057..3519215) Escherichia coli O157:H7 str. Sakai 914757 NP_311555.1 CDS ECs3528 NC_002695.1 3519398 3519697 D similar to B2667_ECOLI gi|1789021 (conserved in Escherichia coli K-12); hypothetical protein 3519398..3519697 Escherichia coli O157:H7 str. Sakai 914756 NP_311556.1 CDS ECs3529 NC_002695.1 3519707 3520225 D similar to YGAP_ECOLI gi|1789022 (conserved in Escherichia coli K-12); hypothetical protein 3519707..3520225 Escherichia coli O157:H7 str. Sakai 914755 NP_311557.1 CDS ECs3530 NC_002695.1 3520278 3520682 R similar to STPA_ECOLI gi|1789023 (conserved in Escherichia coli K-12); DNA binding protein complement(3520278..3520682) Escherichia coli O157:H7 str. Sakai 914754 NP_311558.1 CDS ECs3531 NC_002695.1 3521350 3521799 D similar to B2670_ECOLI gi|1789025 (conserved in Escherichia coli K-12); hypothetical protein 3521350..3521799 Escherichia coli O157:H7 str. Sakai 914753 NP_311559.1 CDS ECs3532 NC_002695.1 3521836 3522180 R similar to YGAC_ECOLI gi|1789026 (conserved in Escherichia coli K-12); hypothetical protein complement(3521836..3522180) Escherichia coli O157:H7 str. Sakai 914752 NP_311560.2 CDS ECs3533 NC_002695.1 3522332 3522661 D similar to YGAM_ECOLI gi|1789027 (conserved in Escherichia coli K-12); hypothetical protein 3522332..3522661 Escherichia coli O157:H7 str. Sakai 914751 NP_311561.1 CDS ECs3534 NC_002695.1 3522811 3524145 R similar to regulatory proteins e.g. MocR [Sinorhizobium meliloti] gi|1346565|sp|P49309; transcriptional regulator complement(3522811..3524145) Escherichia coli O157:H7 str. Sakai 914750 NP_311562.1 CDS ECs3535 NC_002695.1 3524233 3524664 D similar to conserved hypothetical protein [Streptomyces coelicolor A3(2)] gi|7649565|emb|CAB89054.1; hypothetical protein 3524233..3524664 Escherichia coli O157:H7 str. Sakai 914749 NP_311563.1 CDS ECs3536 NC_002695.1 3524873 3525118 D similar to NRDH_ECOLI gi|1789028 (conserved in Escherichia coli K-12); glutaredoxin-like protein 3524873..3525118 Escherichia coli O157:H7 str. Sakai 914748 NP_311564.1 CDS nrdI NC_002695.1 3525115 3525525 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3525115..3525525 Escherichia coli O157:H7 str. Sakai 914747 NP_311565.1 CDS ECs3538 NC_002695.1 3525498 3527642 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3525498..3527642 Escherichia coli O157:H7 str. Sakai 914746 NP_311566.1 CDS nrdF NC_002695.1 3527652 3528611 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3527652..3528611 Escherichia coli O157:H7 str. Sakai 914745 NP_311567.1 CDS ECs3540 NC_002695.1 3528967 3530169 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding protein 3528967..3530169 Escherichia coli O157:H7 str. Sakai 914744 NP_311568.1 CDS ECs3541 NC_002695.1 3530162 3531226 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3530162..3531226 Escherichia coli O157:H7 str. Sakai 914743 NP_311569.1 CDS proX NC_002695.1 3531283 3532275 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3531283..3532275 Escherichia coli O157:H7 str. Sakai 914742 NP_311570.1 CDS ECs3543 NC_002695.1 3532467 3533651 D similar to B2680_ECOLI gi|1789035, B2681_ECOLI gi|1789036; transporter 3532467..3533651 Escherichia coli O157:H7 str. Sakai 914741 NP_311571.1 CDS ECs3544 NC_002695.1 3533775 3534512 D similar to B2682_ECOLI gi|1789038 (conserved in Escherichia coli K-12); hypothetical protein 3533775..3534512 Escherichia coli O157:H7 str. Sakai 914740 NP_311572.1 CDS ECs3545 NC_002695.1 3534502 3534837 D similar to YGAH_ECOLI gi|1789039 (conserved in Escherichia coli K-12); hypothetical protein 3534502..3534837 Escherichia coli O157:H7 str. Sakai 914739 NP_311573.1 CDS ECs3546 NC_002695.1 3534928 3535458 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3534928..3535458 Escherichia coli O157:H7 str. Sakai 914738 NP_311574.1 CDS ECs3547 NC_002695.1 3535585 3536757 D similar to EMRA_ECOLI gi|1789041 (conserved in Escherichia coli K-12); multidrug resistance secretion protein 3535585..3536757 Escherichia coli O157:H7 str. Sakai 914737 NP_311575.1 CDS ECs3548 NC_002695.1 3536774 3538312 D similar to EMRB_ECOLI gi|1789042 (conserved in Escherichia coli K-12); multidrug resistance protein B 3536774..3538312 Escherichia coli O157:H7 str. Sakai 914736 NP_311576.1 CDS ECs3549 NC_002695.1 3538376 3538891 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(3538376..3538891) Escherichia coli O157:H7 str. Sakai 914734 NP_311577.1 CDS ECs3550 NC_002695.1 3539041 3540597 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(3539041..3540597) Escherichia coli O157:H7 str. Sakai 914733 NP_311578.1 CDS ECs3551 NC_002695.1 3540670 3541098 R similar to B2689_ECOLI gi|1789045 (conserved in Escherichia coli K-12); hypothetical protein complement(3540670..3541098) Escherichia coli O157:H7 str. Sakai 914732 NP_311579.1 CDS ECs3552 NC_002695.1 3541095 3541661 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(3541095..3541661) Escherichia coli O157:H7 str. Sakai 914731 NP_311580.1 CDS ECs3553 NC_002695.1 3542889 3543074 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(3542889..3543074) Escherichia coli O157:H7 str. Sakai 914725 NP_311581.1 CDS alaS NC_002695.1 3543309 3545939 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(3543309..3545939) Escherichia coli O157:H7 str. Sakai 914724 NP_311582.1 CDS recX NC_002695.1 3546067 3546567 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(3546067..3546567) Escherichia coli O157:H7 str. Sakai 914723 NP_311583.1 CDS recA NC_002695.1 3546635 3547696 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(3546635..3547696) Escherichia coli O157:H7 str. Sakai 914722 NP_311584.1 CDS ECs3557 NC_002695.1 3547776 3548273 R similar to YGAD_ECOLI gi|1789052 (conserved in Escherichia coli K-12); competence damage-inducible protein A complement(3547776..3548273) Escherichia coli O157:H7 str. Sakai 914721 NP_311585.1 CDS ECs3558 NC_002695.1 3548418 3549503 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(3548418..3549503) Escherichia coli O157:H7 str. Sakai 914720 NP_311587.1 CDS ECs3560 NC_002695.1 3551284 3551655 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3551284..3551655 Escherichia coli O157:H7 str. Sakai 914718 NP_311588.1 CDS ECs3561 NC_002695.1 3551659 3552438 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3551659..3552438 Escherichia coli O157:H7 str. Sakai 914717 NP_311589.1 CDS ECs3562 NC_002695.1 3552544 3552903 D regulator for glucitol utilization; GutM family transcriptional regulator 3552544..3552903 Escherichia coli O157:H7 str. Sakai 914716 NP_311590.1 CDS srlR NC_002695.1 3552970 3553743 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3552970..3553743 Escherichia coli O157:H7 str. Sakai 914715 NP_311591.2 CDS gutQ NC_002695.1 3553736 3554701 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3553736..3554701 Escherichia coli O157:H7 str. Sakai 914714 NP_311592.2 CDS ECs3565 NC_002695.1 3554698 3556212 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator complement(3554698..3556212) Escherichia coli O157:H7 str. Sakai 914713 NP_311593.1 CDS ECs3566 NC_002695.1 3556399 3557634 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3556399..3557634 Escherichia coli O157:H7 str. Sakai 914712 NP_311594.1 CDS ECs3567 NC_002695.1 3557631 3558764 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3557631..3558764 Escherichia coli O157:H7 str. Sakai 914711 NP_311595.1 CDS ECs3568 NC_002695.1 3558892 3561144 R similar to HYPF_ECOLI gi|2367152 (conserved in Escherichia coli K-12); transcriptional regulatory protein complement(3558892..3561144) Escherichia coli O157:H7 str. Sakai 914710 NP_311596.1 CDS ECs3569 NC_002695.1 3561297 3561824 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(3561297..3561824) Escherichia coli O157:H7 str. Sakai 914709 NP_311597.1 CDS ECs3570 NC_002695.1 3561973 3562986 R similar to ASCG_ECOLI gi|1789068 (conserved in Escherichia coli K-12); ascBF operon repressor complement(3561973..3562986) Escherichia coli O157:H7 str. Sakai 914708 NP_311598.1 CDS ECs3571 NC_002695.1 3563243 3564700 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3563243..3564700 Escherichia coli O157:H7 str. Sakai 914707 NP_311599.1 CDS ECs3572 NC_002695.1 3564709 3566133 D similar to ASCB_ECOLI gi|1789070 (conserved in Escherichia coli K-12); cryptic 6-phospho-beta-glucosidase 3564709..3566133 Escherichia coli O157:H7 str. Sakai 914706 NP_311600.1 CDS hycI NC_002695.1 3566257 3566727 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(3566257..3566727) Escherichia coli O157:H7 str. Sakai 914705 NP_311601.1 CDS ECs3574 NC_002695.1 3566720 3567130 R similar to HYCH_ECOLI gi|1789073 (conserved in Escherichia coli K-12); formate hydrogenlyase maturation protein complement(3566720..3567130) Escherichia coli O157:H7 str. Sakai 914704 NP_311602.1 CDS ECs3575 NC_002695.1 3567127 3567894 R similar to HYCG_ECOLI gi|1789074 (conserved in Escherichia coli K-12); formate hydrogenlyase subunit-7 component G complement(3567127..3567894) Escherichia coli O157:H7 str. Sakai 914703 NP_311603.1 CDS ECs3576 NC_002695.1 3567894 3568436 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(3567894..3568436) Escherichia coli O157:H7 str. Sakai 914702 NP_311604.1 CDS ECs3577 NC_002695.1 3568446 3570155 R similar to HYCE_ECOLI gi|1789076 (conserved in Escherichia coli K-12); hydrogenase 3 large subunit complement(3568446..3570155) Escherichia coli O157:H7 str. Sakai 914701 NP_311605.1 CDS ECs3578 NC_002695.1 3570173 3571096 R similar to HYCD_ECOLI gi|1789077 (conserved in Escherichia coli K-12); membrane-spanning protein of hydrogenase 3 complement(3570173..3571096) Escherichia coli O157:H7 str. Sakai 914700 NP_311606.1 CDS ECs3579 NC_002695.1 3571099 3572925 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(3571099..3572925) Escherichia coli O157:H7 str. Sakai 914699 NP_311607.1 CDS ECs3580 NC_002695.1 3572922 3573533 R similar to HYCB_ECOLI gi|1789079 (conserved in Escherichia coli K-12); formate hydrogenlyase subunit-7 component B complement(3572922..3573533) Escherichia coli O157:H7 str. Sakai 914698 NP_311608.1 CDS ECs3581 NC_002695.1 3573658 3574119 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(3573658..3574119) Escherichia coli O157:H7 str. Sakai 914697 NP_311609.1 CDS hypA NC_002695.1 3574331 3574681 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3574331..3574681 Escherichia coli O157:H7 str. Sakai 914696 NP_311610.1 CDS ECs3583 NC_002695.1 3574685 3575557 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3574685..3575557 Escherichia coli O157:H7 str. Sakai 914695 NP_311611.1 CDS ECs3584 NC_002695.1 3575548 3575820 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3575548..3575820 Escherichia coli O157:H7 str. Sakai 914694 NP_311612.1 CDS ECs3585 NC_002695.1 3575820 3576941 D hydrogenase isoenzyme; similar to HYPD_ECOLI gi|1789084 (conserved in Escherichia coli K-12); hypothetical protein 3575820..3576941 Escherichia coli O157:H7 str. Sakai 914693 NP_311613.1 CDS ECs3586 NC_002695.1 3576980 3577948 D similar to HYPE_ECOLI gi|1789085 (conserved in Escherichia coli K-12); hypothetical protein 3576980..3577948 Escherichia coli O157:H7 str. Sakai 914692 NP_311614.1 CDS ECs3587 NC_002695.1 3578022 3580100 D similar to FHLA_ECOLI gi|1789087 (conserved in Escherichia coli K-12); formate hydrogenlyase transcriptional activator 3578022..3580100 Escherichia coli O157:H7 str. Sakai 914691 NP_311615.1 CDS ECs3588 NC_002695.1 3580137 3580490 R similar to YGBA_ECOLI gi|1789088 (conserved in Escherichia coli K-12); hypothetical protein complement(3580137..3580490) Escherichia coli O157:H7 str. Sakai 914690 NP_311616.1 CDS ECs3589 NC_002695.1 3580777 3583338 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3580777..3583338 Escherichia coli O157:H7 str. Sakai 914689 NP_311617.1 CDS ECs3590 NC_002695.1 3583444 3584100 D similar to PPHB_ECOLI gi|1789090 (conserved in Escherichia coli K-12); serine/threonine-specific protein phosphatase 2 3583444..3584100 Escherichia coli O157:H7 str. Sakai 914688 NP_311618.1 CDS ECs3591 NC_002695.1 3584141 3584377 R similar to hypothetical proteins e.g. VdcD [Streptomyces sp. D7] gi|4741970|gb|AAD28783.1|AF134589_3, YclD [Bacillus subtilis] gi|7452267|pir||A69762; hypothetical protein complement(3584141..3584377) Escherichia coli O157:H7 str. Sakai 914687 NP_311619.1 CDS ECs3592 NC_002695.1 3584388 3585815 R similar to YclC [Escherichia coli O157:H7] gi|4887556|emb|CAB43499.1|, VdcC [Streptomyces sp. D7] gi|6686069|sp|Q9X697|VDCC_STRD7; 4-hydroxybenzoate decarboxylase complement(3584388..3585815) Escherichia coli O157:H7 str. Sakai 914686 NP_311620.1 CDS ECs3593 NC_002695.1 3585815 3586408 R similar to Pad1 [Escherichia coli O157:H7] gi|4887557|emb|CAB43500.1|, phenylacrylic acid decarboxylases e.g. VdcB [Streptomyces sp. D7]; phenylacrylic acid decarboxylase complement(3585815..3586408) Escherichia coli O157:H7 str. Sakai 914685 NP_311621.1 CDS ECs3594 NC_002695.1 3586555 3586962 D similar to SlyA [Escherichia coli O157:H7] to gi|4887558|emb|CAB43501.1|, transcriptional regulators e.g. [Streptomyces coelicolor] gi|7481485|pir||T35022; MarR family transcriptional regulator 3586555..3586962 Escherichia coli O157:H7 str. Sakai 914684 NP_311622.1 CDS ECs3595 NC_002695.1 3587082 3588074 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(3587082..3588074) Escherichia coli O157:H7 str. Sakai 914683 NP_311623.1 CDS nlpD NC_002695.1 3588137 3589276 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; Nlp family transcriptional regulator complement(3588137..3589276) Escherichia coli O157:H7 str. Sakai 914682 NP_311624.1 CDS pcm NC_002695.1 3589416 3590042 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(3589416..3590042) Escherichia coli O157:H7 str. Sakai 914681 NP_311625.1 CDS surE NC_002695.1 3590036 3590797 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(3590036..3590797) Escherichia coli O157:H7 str. Sakai 914680 NP_311626.1 CDS truD NC_002695.1 3590778 3591827 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(3590778..3591827) Escherichia coli O157:H7 str. Sakai 914679 NP_311627.1 CDS ispF NC_002695.1 3591824 3592303 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(3591824..3592303) Escherichia coli O157:H7 str. Sakai 914678 NP_311628.1 CDS ispD NC_002695.1 3592303 3593013 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(3592303..3593013) Escherichia coli O157:H7 str. Sakai 914677 NP_311629.1 CDS ftsB NC_002695.1 3593032 3593343 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(3593032..3593343) Escherichia coli O157:H7 str. Sakai 914676 NP_311630.1 CDS ECs3603 NC_002695.1 3593537 3593860 R similar to YGBE_ECOLI gi|1789106 (conserved in Escherichia coli K-12); hypothetical protein complement(3593537..3593860) Escherichia coli O157:H7 str. Sakai 914675 NP_311631.1 CDS ECs3604 NC_002695.1 3593910 3594515 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(3593910..3594515) Escherichia coli O157:H7 str. Sakai 914674 NP_311632.1 CDS cysN NC_002695.1 3594515 3595942 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(3594515..3595942) Escherichia coli O157:H7 str. Sakai 914673 NP_311633.1 CDS ECs3606 NC_002695.1 3595944 3596852 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(3595944..3596852) Escherichia coli O157:H7 str. Sakai 914672 NP_311634.1 CDS ECs3607 NC_002695.1 3597104 3598141 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3597104..3598141 Escherichia coli O157:H7 str. Sakai 914671 NP_311635.1 CDS ECs3608 NC_002695.1 3598531 3598824 R similar to hypothetical protein [Escherichia coli] gi|7404494|sp|P45956|YGBF_ECOLI; hypothetical protein complement(3598531..3598824) Escherichia coli O157:H7 str. Sakai 914670 NP_311636.1 CDS ECs3609 NC_002695.1 3598821 3599744 R similar to hypothetical protein b2755 [Escherichia coli strain K-12] gi|7460139|pir||G65056; hypothetical protein complement(3598821..3599744) Escherichia coli O157:H7 str. Sakai 914669 NP_311637.1 CDS ECs3610 NC_002695.1 3599741 3600391 R similar to hypothetical protein b2756 [Escherichia coli strain K-12] gi|6136707|sp|Q46897|YGCH_ECOLI; hypothetical protein complement(3599741..3600391) Escherichia coli O157:H7 str. Sakai 914668 NP_311638.1 CDS ECs3611 NC_002695.1 3600373 3601119 R similar to hypothetical protein b2757 [Escherichia coli strain K-12] gi|7459357|pir||A65057; hypothetical protein complement(3600373..3601119) Escherichia coli O157:H7 str. Sakai 914667 NP_311639.1 CDS ECs3612 NC_002695.1 3601130 3602185 R similar to hypothetical protein b2758 [Escherichia coli strain K-12] gi|7476186|pir||C70849; hypothetical protein complement(3601130..3602185) Escherichia coli O157:H7 str. Sakai 914666 NP_311640.1 CDS ECs3613 NC_002695.1 3602197 3602733 R hypothetical protein complement(3602197..3602733) Escherichia coli O157:H7 str. Sakai 914665 NP_311641.1 CDS ECs3614 NC_002695.1 3602730 3604292 R similar to hypothetical protein b2760 [Escherichia coli strain K-12] gi|7451979|pir||D65057; hypothetical protein complement(3602730..3604292) Escherichia coli O157:H7 str. Sakai 914664 NP_311642.1 CDS ECs3615 NC_002695.1 3604390 3607047 R similar to hypothetical protein YgcB [Escherichia coli strain K-12] gi|2506493|sp|P38036|YGCB_ECOLI; hypothetical protein complement(3604390..3607047) Escherichia coli O157:H7 str. Sakai 914663 NP_311643.1 CDS ECs3616 NC_002695.1 3607281 3607433 R similar to YBDY_ECOLI gi|3025009|sp|P77091, SrnB [Plasmid F] dad|AP001918-5|BAA97875.1; hypothetical protein complement(3607281..3607433) Escherichia coli O157:H7 str. Sakai 914662 NP_311644.1 CDS ECs3617 NC_002695.1 3607697 3608431 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(3607697..3608431) Escherichia coli O157:H7 str. Sakai 914661 NP_311645.1 CDS ECs3618 NC_002695.1 3608505 3610217 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(3608505..3610217) Escherichia coli O157:H7 str. Sakai 914660 NP_311646.1 CDS cysJ NC_002695.1 3610217 3612016 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(3610217..3612016) Escherichia coli O157:H7 str. Sakai 914659 NP_311647.1 CDS ECs3620 NC_002695.1 3612332 3612697 D similar to YGCM_ECOLI gi|1789124 (conserved in Escherichia coli K-12); 6-pyruvoyl tetrahydrobiopterin synthase 3612332..3612697 Escherichia coli O157:H7 str. Sakai 914658 NP_311648.2 CDS ECs3621 NC_002695.1 3612775 3614046 D similar to YGCN_ECOLI gi|1789125 (conserved in Escherichia coli K-12); hypothetical protein 3612775..3614046 Escherichia coli O157:H7 str. Sakai 914657 NP_311649.1 CDS ECs3622 NC_002695.1 3614001 3614297 D similar to YGCO_ECOLI gi|1789126 (conserved in Escherichia coli K-12); hypothetical protein 3614001..3614297 Escherichia coli O157:H7 str. Sakai 914656 NP_311650.1 CDS ECs3623 NC_002695.1 3614314 3614889 D similar to YGCP_ECOLI gi|1789127 (conserved in Escherichia coli K-12); anti-terminator regulatory protein 3614314..3614889 Escherichia coli O157:H7 str. Sakai 914655 NP_311653.1 CDS ECs3626 NC_002695.1 3615894 3616679 R similar to YGCR_ECOLI gi|2367158 (conserved in Escherichia coli K-12); transporter complement(3615894..3616679) Escherichia coli O157:H7 str. Sakai 914651 NP_311656.1 CDS ECs3629 NC_002695.1 3618081 3619535 R similar to YGCU_ECOLI gi|2367159, B2772_ECOLI gi|1789131; hypothetical protein complement(3618081..3619535) Escherichia coli O157:H7 str. Sakai 914648 NP_311657.2 CDS ECs3630 NC_002695.1 3619605 3620390 R similar to YGCW_ECOLI gi|1789135 (conserved in Escherichia coli K-12); oxidoreductase complement(3619605..3620390) Escherichia coli O157:H7 str. Sakai 914647 NP_311658.1 CDS ECs3631 NC_002695.1 3620709 3621986 D similar to YQCE_ECOLI gi|2367161 (conserved in Escherichia coli K-12); transporter 3620709..3621986 Escherichia coli O157:H7 str. Sakai 914646 NP_311659.1 CDS ECs3632 NC_002695.1 3622013 3623491 D similar to YGCE_ECOLI gi|1789138 (conserved in Escherichia coli K-12); kinase 3622013..3623491 Escherichia coli O157:H7 str. Sakai 914645 NP_311660.1 CDS ECs3633 NC_002695.1 3624555 3625226 R similar to YGCF_ECOLI gi|1789139 (conserved in Escherichia coli K-12); hypothetical protein complement(3624555..3625226) Escherichia coli O157:H7 str. Sakai 912281 NP_311661.1 CDS ECs3634 NC_002695.1 3625606 3626001 D similar to hypothetical proteins e.g. Tp70 [Treponema pallidum] gi|7521576|pir||A71309; hypothetical protein 3625606..3626001 Escherichia coli O157:H7 str. Sakai 917122 NP_311662.1 CDS ECs3635 NC_002695.1 3626015 3626689 D similar to N-terminal parts of hypothetical proteins e.g. YgcG [Escherichia coli] gi|1723817|sp|P55140|YGCG_ECOLI; hypothetical protein 3626015..3626689 Escherichia coli O157:H7 str. Sakai 916569 NP_311664.1 CDS ECs3637 NC_002695.1 3626923 3628071 D similar to hypothetical protein YgcG Escherichia coli P55140; hypothetical protein 3626923..3628071 Escherichia coli O157:H7 str. Sakai 916562 NP_311665.2 CDS ECs3638 NC_002695.1 3628077 3628982 D similar to YGCG_ECOLI gi|1789140, hypothetical protein [Pseudomonas aeruginosa] dad|AE004490-5|AAG03925.1; hypothetical protein 3628077..3628982 Escherichia coli O157:H7 str. Sakai 916561 NP_311666.1 CDS eno NC_002695.1 3629042 3630340 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(3629042..3630340) Escherichia coli O157:H7 str. Sakai 916564 NP_311667.1 CDS pyrG NC_002695.1 3630428 3632065 R CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(3630428..3632065) Escherichia coli O157:H7 str. Sakai 914930 NP_311668.1 CDS mazG NC_002695.1 3632293 3633084 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase complement(3632293..3633084) Escherichia coli O157:H7 str. Sakai 916566 NP_311669.1 CDS ECs3642 NC_002695.1 3633155 3633490 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(3633155..3633490) Escherichia coli O157:H7 str. Sakai 916551 NP_311670.1 CDS ECs3643 NC_002695.1 3633490 3633738 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(3633490..3633738) Escherichia coli O157:H7 str. Sakai 916553 NP_311671.1 CDS relA NC_002695.1 3633816 3636050 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(3633816..3636050) Escherichia coli O157:H7 str. Sakai 916555 NP_311672.1 CDS rumA NC_002695.1 3636098 3637399 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(3636098..3637399) Escherichia coli O157:H7 str. Sakai 916557 NP_311673.1 CDS ECs3646 NC_002695.1 3637456 3640212 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3637456..3640212 Escherichia coli O157:H7 str. Sakai 916559 NP_311674.1 CDS ECs3647 NC_002695.1 3640445 3641785 R similar to YGCX_ECOLI gi|1789150 (conserved in Escherichia coli K-12); glucarate dehydratase complement(3640445..3641785) Escherichia coli O157:H7 str. Sakai 916552 NP_311675.1 CDS ECs3648 NC_002695.1 3641806 3642828 R similar to YGCY_ECOLI gi|1789151; glucarate dehydratase complement(3641806..3642828) Escherichia coli O157:H7 str. Sakai 916543 NP_311676.1 CDS ECs3649 NC_002695.1 3643148 3644500 R similar to B2789_ECOLI gi|1789152 (conserved in Escherichia coli K-12); transporter complement(3643148..3644500) Escherichia coli O157:H7 str. Sakai 916547 NP_311677.1 CDS ECs3650 NC_002695.1 3644935 3645384 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3644935..3645384) Escherichia coli O157:H7 str. Sakai 916549 NP_311678.1 CDS ECs3651 NC_002695.1 3645402 3646184 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(3645402..3646184) Escherichia coli O157:H7 str. Sakai 916545 NP_311679.1 CDS ECs3652 NC_002695.1 3646184 3646513 R similar to B2792_ECOLI gi|1789156 (conserved in Escherichia coli K-12); hypothetical protein complement(3646184..3646513) Escherichia coli O157:H7 str. Sakai 916544 NP_311680.1 CDS ECs3653 NC_002695.1 3647135 3647680 R SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(3647135..3647680) Escherichia coli O157:H7 str. Sakai 916531 NP_311681.1 CDS queF NC_002695.1 3647748 3648596 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3647748..3648596 Escherichia coli O157:H7 str. Sakai 916536 NP_311682.1 CDS ECs3655 NC_002695.1 3648708 3650072 D similar to YGDH_ECOLI gi|1789159 (conserved in Escherichia coli K-12); hypothetical protein 3648708..3650072 Escherichia coli O157:H7 str. Sakai 916540 NP_311683.1 CDS ECs3656 NC_002695.1 3650629 3651918 D similar to SDAC_ECOLI gi|1789160 (conserved in Escherichia coli K-12); serine transporter 3650629..3651918 Escherichia coli O157:H7 str. Sakai 916539 NP_311684.1 CDS ECs3657 NC_002695.1 3651976 3653343 D similar to SDAA_ECOLI gi|1788116 (conserved in Escherichia coli K-12); L-serine dehydratase 3651976..3653343 Escherichia coli O157:H7 str. Sakai 916537 NP_311685.2 CDS xni NC_002695.1 3653455 3654210 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3653455..3654210 Escherichia coli O157:H7 str. Sakai 916535 NP_311686.1 CDS ECs3659 NC_002695.1 3654265 3655416 R similar to FUCO_ECOLI gi|1789163 (conserved in Escherichia coli K-12); L-1,2-propanediol oxidoreductase complement(3654265..3655416) Escherichia coli O157:H7 str. Sakai 916534 NP_311687.1 CDS ECs3660 NC_002695.1 3655441 3656088 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(3655441..3656088) Escherichia coli O157:H7 str. Sakai 916460 NP_311688.1 CDS ECs3661 NC_002695.1 3656635 3657951 D similar to FUCP_ECOLI gi|1789166 (conserved in Escherichia coli K-12); L-fucose transporter 3656635..3657951 Escherichia coli O157:H7 str. Sakai 916474 NP_311689.1 CDS fucI NC_002695.1 3657984 3659759 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3657984..3659759 Escherichia coli O157:H7 str. Sakai 916477 NP_311690.1 CDS ECs3663 NC_002695.1 3659838 3661286 D similar to FUCK_ECOLI gi|1789168 (conserved in Escherichia coli K-12); L-fuculokinase 3659838..3661286 Escherichia coli O157:H7 str. Sakai 916532 NP_311691.1 CDS ECs3664 NC_002695.1 3661288 3661710 D similar to FUCU_ECOLI gi|1789169 (conserved in Escherichia coli K-12); FucU 3661288..3661710 Escherichia coli O157:H7 str. Sakai 916530 NP_311692.1 CDS ECs3665 NC_002695.1 3661768 3662499 D regulates expression of genes involved in L-fucose utilization; FucR family transcriptional regulator 3661768..3662499 Escherichia coli O157:H7 str. Sakai 916529 NP_311693.1 CDS ECs3666 NC_002695.1 3662543 3663643 R similar to YGDE_ECOLI gi|1789171 (conserved in Escherichia coli K-12); RNA 2'-O-ribose methyltransferase complement(3662543..3663643) Escherichia coli O157:H7 str. Sakai 916522 NP_311694.1 CDS ECs3667 NC_002695.1 3663636 3664031 R similar to YGDD_ECOLI gi|1789172 (conserved in Escherichia coli K-12); hypothetical protein complement(3663636..3664031) Escherichia coli O157:H7 str. Sakai 916523 NP_311695.1 CDS ECs3668 NC_002695.1 3664050 3664967 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; GcvA family transcriptional regulator complement(3664050..3664967) Escherichia coli O157:H7 str. Sakai 916524 NP_311696.1 CDS ECs3669 NC_002695.1 3665318 3665548 R similar to B2809_ECOLI gi|1789174 (conserved in Escherichia coli K-12); hypothetical protein complement(3665318..3665548) Escherichia coli O157:H7 str. Sakai 916528 NP_311697.1 CDS ECs3670 NC_002695.1 3665737 3666942 D similar to B2810_ECOLI gi|1789175 (conserved in Escherichia coli K-12); cysteine sulfinate desulfinase 3665737..3666942 Escherichia coli O157:H7 str. Sakai 916527 NP_311698.1 CDS ECs3671 NC_002695.1 3666942 3667385 D similar to YGDK_ECOLI gi|1789176 (conserved in Escherichia coli K-12); hypothetical protein 3666942..3667385 Escherichia coli O157:H7 str. Sakai 916526 NP_311699.1 CDS ECs3672 NC_002695.1 3667436 3668242 R similar to YGDL_ECOLI gi|1789177 (conserved in Escherichia coli K-12); hypothetical protein complement(3667436..3668242) Escherichia coli O157:H7 str. Sakai 916509 NP_311700.1 CDS mltA NC_002695.1 3668481 3669578 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(3668481..3669578) Escherichia coli O157:H7 str. Sakai 916516 NP_311701.2 CDS ECs3674 NC_002695.1 3670157 3671410 R similar to B2817_ECOLI gi|1789180 (conserved in Escherichia coli K-12); amidase complement(3670157..3671410) Escherichia coli O157:H7 str. Sakai 916515 NP_311702.1 CDS ECs3675 NC_002695.1 3671642 3672973 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3671642..3672973 Escherichia coli O157:H7 str. Sakai 916513 NP_311703.1 CDS recD NC_002695.1 3673035 3674861 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3673035..3674861) Escherichia coli O157:H7 str. Sakai 916512 NP_311704.1 CDS recB NC_002695.1 3674861 3678403 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3674861..3678403) Escherichia coli O157:H7 str. Sakai 916511 NP_311705.1 CDS ECs3678 NC_002695.1 3678396 3681284 R similar to PTR_ECOLI gi|2367164 (conserved in Escherichia coli K-12); protease III complement(3678396..3681284) Escherichia coli O157:H7 str. Sakai 916510 NP_311706.1 CDS recC NC_002695.1 3681460 3684828 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3681460..3684828) Escherichia coli O157:H7 str. Sakai 916502 NP_311707.1 CDS ECs3680 NC_002695.1 3684841 3685164 R similar to PPDC_ECOLI gi|1789187 (conserved in Escherichia coli K-12); hypothetical protein complement(3684841..3685164) Escherichia coli O157:H7 str. Sakai 916503 NP_311708.2 CDS ECs3681 NC_002695.1 3685149 3685556 R similar to YGDB_ECOLI gi|1789188 (conserved in Escherichia coli K-12); hypothetical protein complement(3685149..3685556) Escherichia coli O157:H7 str. Sakai 916506 NP_311709.1 CDS ECs3682 NC_002695.1 3685553 3686116 R similar to PPDB_ECOLI gi|1789189 (conserved in Escherichia coli K-12); hypothetical protein complement(3685553..3686116) Escherichia coli O157:H7 str. Sakai 916507 NP_311710.1 CDS ECs3683 NC_002695.1 3686107 3686577 R similar to PPDA_ECOLI gi|1789190 (conserved in Escherichia coli K-12); hypothetical protein complement(3686107..3686577) Escherichia coli O157:H7 str. Sakai 916504 NP_311711.1 CDS thyA NC_002695.1 3686761 3687555 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3686761..3687555) Escherichia coli O157:H7 str. Sakai 916501 NP_311712.1 CDS ECs3685 NC_002695.1 3687562 3688437 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3687562..3688437) Escherichia coli O157:H7 str. Sakai 916500 NP_311713.1 CDS ECs3686 NC_002695.1 3688588 3690834 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(3688588..3690834) Escherichia coli O157:H7 str. Sakai 916498 NP_311714.1 CDS ECs3687 NC_002695.1 3690847 3691377 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3690847..3691377) Escherichia coli O157:H7 str. Sakai 916489 NP_311715.1 CDS ECs3688 NC_002695.1 3692062 3692751 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3692062..3692751 Escherichia coli O157:H7 str. Sakai 916491 NP_311716.1 CDS ECs3689 NC_002695.1 3692820 3693533 D similar to B2832_ECOLI gi|1789197 (conserved in Escherichia coli K-12); transporter 3692820..3693533 Escherichia coli O157:H7 str. Sakai 916496 NP_311717.1 CDS ECs3690 NC_002695.1 3693671 3693889 D similar to B2833_ECOLI gi|1789198 (conserved in Escherichia coli K-12); hypothetical protein 3693671..3693889 Escherichia coli O157:H7 str. Sakai 916497 NP_311718.1 CDS tas NC_002695.1 3693997 3695037 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo/keto reductase 3693997..3695037 Escherichia coli O157:H7 str. Sakai 916495 NP_311719.1 CDS ECs3692 NC_002695.1 3695069 3696262 R similar to YGED_ECOLI gi|1789200 (conserved in Escherichia coli K-12); lysophospholipid transporter LplT complement(3695069..3696262) Escherichia coli O157:H7 str. Sakai 916494 NP_311720.1 CDS ECs3693 NC_002695.1 3696255 3698414 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-ACP synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3696255..3698414) Escherichia coli O157:H7 str. Sakai 916493 NP_311721.1 CDS ECs3694 NC_002695.1 3699000 3700031 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3699000..3700031 Escherichia coli O157:H7 str. Sakai 916490 NP_311722.1 CDS ECs3695 NC_002695.1 3700038 3701300 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3700038..3701300) Escherichia coli O157:H7 str. Sakai 916478 NP_311723.1 CDS ECs3696 NC_002695.1 3701422 3702357 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 3701422..3702357 Escherichia coli O157:H7 str. Sakai 916476 NP_311724.1 CDS ECs3697 NC_002695.1 3702344 3703036 R similar to YGEA_ECOLI gi|1789205 (conserved in Escherichia coli K-12); racemase complement(3702344..3703036) Escherichia coli O157:H7 str. Sakai 916475 NP_311725.1 CDS ECs3698 NC_002695.1 3703165 3704583 R similar to ARAE_ECOLI gi|1789207 (conserved in Escherichia coli K-12); low-affinity L-arabinose transport system proton symport protein complement(3703165..3704583) Escherichia coli O157:H7 str. Sakai 916479 NP_311726.1 CDS ECs3699 NC_002695.1 3704898 3705659 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3704898..3705659) Escherichia coli O157:H7 str. Sakai 916482 NP_311727.1 CDS ECs3700 NC_002695.1 3705689 3706525 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3705689..3706525) Escherichia coli O157:H7 str. Sakai 916485 NP_311728.2 CDS ECs3701 NC_002695.1 3706812 3707993 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3706812..3707993) Escherichia coli O157:H7 str. Sakai 916487 NP_311729.1 CDS ECs3702 NC_002695.1 3708248 3709477 D similar to B2845_ECOLI gi|1789211 (conserved in Escherichia coli K-12); transporter protein 3708248..3709477 Escherichia coli O157:H7 str. Sakai 916486 NP_311730.1 CDS ECs3703 NC_002695.1 3709877 3710569 D similar to YQEH_ECOLI gi|1789212 (conserved in Escherichia coli K-12); hypothetical protein 3709877..3710569 Escherichia coli O157:H7 str. Sakai 916484 NP_311731.1 CDS ECs3704 NC_002695.1 3710903 3711712 D similar to YQEI_ECOLI gi|1789213 (conserved in Escherichia coli K-12); sensory transducer 3710903..3711712 Escherichia coli O157:H7 str. Sakai 916483 NP_311732.1 CDS ECs3705 NC_002695.1 3711709 3712188 D similar to YQEJ_ECOLI gi|2367166 (conserved in Escherichia coli K-12); hypothetical protein 3711709..3712188 Escherichia coli O157:H7 str. Sakai 916481 NP_311733.2 CDS ECs3706 NC_002695.1 3712337 3712762 R similar to YQEK_ECOLI gi|2367167 (conserved in Escherichia coli K-12); hypothetical protein complement(3712337..3712762) Escherichia coli O157:H7 str. Sakai 916480 NP_311734.1 CDS ECs3707 NC_002695.1 3713192 3713683 D similar to YGEF_ECOLI gi|2367169 (conserved in Escherichia coli K-12); hypothetical protein 3713192..3713683 Escherichia coli O157:H7 str. Sakai 916473 NP_311735.1 CDS ECs3708 NC_002695.1 3713909 3714400 D similar to YGEG_ECOLI gi|1789215 (conserved in Escherichia coli K-12); hypothetical protein 3713909..3714400 Escherichia coli O157:H7 str. Sakai 916472 NP_311736.1 CDS ECs3709 NC_002695.1 3714734 3716110 D similar to YGEH_ECOLI gi|1789216 (conserved in Escherichia coli K-12); transcriptional regulator 3714734..3716110 Escherichia coli O157:H7 str. Sakai 916471 NP_311737.1 CDS ECs3710 NC_002695.1 3716277 3716495 D similar to B2853_ECOLI gi|1789217 (conserved in Escherichia coli K-12); hypothetical protein 3716277..3716495 Escherichia coli O157:H7 str. Sakai 916470 NP_311738.1 CDS ECs3711 NC_002695.1 3716682 3717083 D similar to B2854_ECOLI gi|1789218 (conserved in Escherichia coli K-12); hypothetical protein 3716682..3717083 Escherichia coli O157:H7 str. Sakai 916469 NP_311739.1 CDS ECs3712 NC_002695.1 3717102 3717734 R similar to b2856_ECOLI gi|1789220, YGEK_ECOLI gi|1789219; hypothetical protein complement(3717102..3717734) Escherichia coli O157:H7 str. Sakai 916468 NP_311740.1 CDS ECs3713 NC_002695.1 3717957 3718388 R similar to B2857_ECOLI gi|1789221 (conserved in Escherichia coli K-12); hypothetical protein complement(3717957..3718388) Escherichia coli O157:H7 str. Sakai 916467 NP_311741.1 CDS ECs3714 NC_002695.1 3718405 3718665 R similar to B2858_ECOLI gi|1789222 (conserved in Escherichia coli K-12); hypothetical protein complement(3718405..3718665) Escherichia coli O157:H7 str. Sakai 916466 NP_311742.1 CDS ECs3715 NC_002695.1 3718607 3719188 R similar to B2859_ECOLI gi|1789223 (conserved in Escherichia coli K-12); hypothetical protein complement(3718607..3719188) Escherichia coli O157:H7 str. Sakai 916465 NP_311743.1 CDS ECs3716 NC_002695.1 3719204 3719938 R lipoprotein precursor (type III secretion system); similar to lipoprotein precursors in type III secretion system e.g. PrgK protein [Salmonella typhimurium] gi|1172615|sp|P41786|PRGK_SALTY; type III secretion system lipoprotein precursor; EprK complement(3719204..3719938) Escherichia coli O157:H7 str. Sakai 916464 NP_311744.1 CDS ECs3717 NC_002695.1 3719935 3720267 R similar to PrgJ [Salmonella typhimurium] gi|1172614|sp|P41785|PRGJ_SALTY, MxiI [Shigella flexneri] gi|547954|sp|Q06080|MXII_SHIFL; type III secretion protein; EprJ complement(3719935..3720267) Escherichia coli O157:H7 str. Sakai 916459 NP_311745.1 CDS ECs3718 NC_002695.1 3720287 3720526 R similar to type III secretion proteins e.g. PrgI protein [Salmonella typhimurium] gi|1172613|sp|P41784|PRGI_SALTY; EprI complement(3720287..3720526) Escherichia coli O157:H7 str. Sakai 916461 NP_311746.1 CDS ECs3719 NC_002695.1 3720540 3721274 R similar to MxiG [Shigella flexneri] gi|2498603|sp|Q57332|MXIG_SHIFL, PrgH protein [Salmonella typhimurium] gi|1172612|sp|P41783|PRGH_SALTY; type III secretion protein; EprH complement(3720540..3721274) Escherichia coli O157:H7 str. Sakai 916462 NP_311747.1 CDS ECs3720 NC_002695.1 3721978 3722478 D similar to transcriptional activator NtrC [Herbaspirillum seropedicae] gi|57313501|gb|AAC32391.21; transcriptional regulator 3721978..3722478 Escherichia coli O157:H7 str. Sakai 916463 NP_311748.1 CDS ECs3721 NC_002695.1 3722835 3723956 R Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS complement(3722835..3723956) Escherichia coli O157:H7 str. Sakai 916456 NP_311751.1 CDS ECs3724 NC_002695.1 3724734 3724994 R similar to type III secretion proteins e.g. SpaQ [Salmonella enterica] gi|975756|gb|AAC43847.1|; EpaQ complement(3724734..3724994) Escherichia coli O157:H7 str. Sakai 916521 NP_311752.1 CDS spaP NC_002695.1 3725005 3725670 R part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP complement(3725005..3725670) Escherichia coli O157:H7 str. Sakai 916444 NP_311753.1 CDS ECs3726 NC_002695.1 3725660 3726646 R involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; surface presentation of antigens protein SpaO complement(3725660..3726646) Escherichia coli O157:H7 str. Sakai 916445 NP_311754.1 CDS ECs3727 NC_002695.1 3726606 3727223 R similar to type III secretion proteins e.g. SpaN [Salmonella enterica] gi|1155289|gb|AAC44993.1; EivJ complement(3726606..3727223) Escherichia coli O157:H7 str. Sakai 916452 NP_311755.1 CDS ECs3728 NC_002695.1 3727248 3727481 R hypothetical protein complement(3727248..3727481) Escherichia coli O157:H7 str. Sakai 916454 NP_311756.1 CDS ECs3729 NC_002695.1 3727459 3727794 R similar to type III secretion proteins e.g. SpaM [Salmonella enterica] gi|1155297|gb|AAC44998.1|; EivI complement(3727459..3727794) Escherichia coli O157:H7 str. Sakai 916453 NP_311757.1 CDS ECs3730 NC_002695.1 3727907 3729226 R Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL complement(3727907..3729226) Escherichia coli O157:H7 str. Sakai 916450 NP_311758.1 CDS ECs3731 NC_002695.1 3729231 3731291 R similar to type III secretion proteins e.g. InvA [Salmonella typhimurium] gi|476819|pir||A42888; EivA complement(3729231..3731291) Escherichia coli O157:H7 str. Sakai 916449 NP_311759.1 CDS ECs3732 NC_002695.1 3731284 3732429 R similar to type III secretion proteins e.g. invasion protein [Salmonella enterica] gi|1236845|gb|AAC45041.1|; EivE complement(3731284..3732429) Escherichia coli O157:H7 str. Sakai 916421 NP_311760.1 CDS ECs3733 NC_002695.1 3732434 3734137 R similar to type III secretion proteins e.g. InvG [Salmonella typhimurium] gi|1170574|sp|P35672|INVG_SALTY; EivG complement(3732434..3734137) Escherichia coli O157:H7 str. Sakai 916419 NP_311761.1 CDS ECs3734 NC_002695.1 3734134 3734883 R similar to transcriptional regulators e.g. invF [Salmonella typhimurium] gi|729852|sp|P39437|INVF_SALTY; transcriptional regulator of type III secretion system; type III secretion protein; EivF complement(3734134..3734883) Escherichia coli O157:H7 str. Sakai 916448 NP_311762.1 CDS ECs3735 NC_002695.1 3735229 3735408 R hypothetical protein complement(3735229..3735408) Escherichia coli O157:H7 str. Sakai 916447 NP_311763.1 CDS ECs3736 NC_002695.1 3735475 3736533 R similar to B2863 gi|1789227 and B2862_ECOLI gi|1789226; hypothetical protein complement(3735475..3736533) Escherichia coli O157:H7 str. Sakai 916438 NP_311764.1 CDS ECs3737 NC_002695.1 3736517 3737122 R similar to B2863_ECOLI gi|1789227; hypothetical protein complement(3736517..3737122) Escherichia coli O157:H7 str. Sakai 916439 NP_311765.2 CDS ECs3738 NC_002695.1 3737466 3738221 R similar to B2865_ECOLI gi|1789228 (conserved in Escherichia coli K-12); lipoprotein complement(3737466..3738221) Escherichia coli O157:H7 str. Sakai 916442 NP_311766.1 CDS ECs3739 NC_002695.1 3738676 3740934 D molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3738676..3740934 Escherichia coli O157:H7 str. Sakai 916443 NP_311767.1 CDS ECs3740 NC_002695.1 3740945 3741823 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3740945..3741823 Escherichia coli O157:H7 str. Sakai 916440 NP_311768.1 CDS ECs3741 NC_002695.1 3741820 3742299 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3741820..3742299 Escherichia coli O157:H7 str. Sakai 916430 NP_311769.1 CDS ECs3742 NC_002695.1 3742339 3744117 R similar to YGEV_ECOLI gi|1789233 (conserved in Escherichia coli K-12); transcriptional regulator complement(3742339..3744117) Escherichia coli O157:H7 str. Sakai 916432 NP_311770.1 CDS ECs3743 NC_002695.1 3744593 3745783 D catalyzes the formation of L-citruline from L-ornithine and carbamoylphosphate; aspartate/ornithine carbamoyltransferase 3744593..3745783 Escherichia coli O157:H7 str. Sakai 916433 NP_311771.1 CDS ECs3744 NC_002695.1 3745841 3747037 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3745841..3747037 Escherichia coli O157:H7 str. Sakai 916434 NP_311772.1 CDS ECs3745 NC_002695.1 3747095 3748306 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3747095..3748306 Escherichia coli O157:H7 str. Sakai 916436 NP_311773.2 CDS ECs3746 NC_002695.1 3748359 3749744 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3748359..3749744 Escherichia coli O157:H7 str. Sakai 916437 NP_311774.1 CDS ECs3747 NC_002695.1 3749792 3750724 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3749792..3750724 Escherichia coli O157:H7 str. Sakai 916431 NP_311775.1 CDS ECs3748 NC_002695.1 3750765 3752390 R similar to B2875_ECOLI gi|1789240 (conserved in Escherichia coli K-12); synthase complement(3750765..3752390) Escherichia coli O157:H7 str. Sakai 916429 NP_311776.1 CDS ECs3749 NC_002695.1 3752438 3753145 R similar to B2876_ECOLI gi|1789241 (conserved in Escherichia coli K-12); hypothetical protein complement(3752438..3753145) Escherichia coli O157:H7 str. Sakai 916423 NP_311777.1 CDS ECs3750 NC_002695.1 3753311 3753889 D similar to YGFJ_ECOLI gi|1789242 (conserved in Escherichia coli K-12); hypothetical protein 3753311..3753889 Escherichia coli O157:H7 str. Sakai 916424 NP_311778.1 CDS ECs3751 NC_002695.1 3754211 3757309 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3754211..3757309 Escherichia coli O157:H7 str. Sakai 916425 NP_311779.1 CDS ECs3752 NC_002695.1 3757312 3758640 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3757312..3758640 Escherichia coli O157:H7 str. Sakai 916426 NP_311780.1 CDS ECs3753 NC_002695.1 3758690 3759469 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3758690..3759469 Escherichia coli O157:H7 str. Sakai 916427 NP_311781.1 CDS ECs3754 NC_002695.1 3759466 3762336 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3759466..3762336 Escherichia coli O157:H7 str. Sakai 916428 NP_311782.1 CDS ECs3755 NC_002695.1 3762444 3763901 D similar to YGFO_ECOLI gi|1789248 (conserved in Escherichia coli K-12); transporter 3762444..3763901 Escherichia coli O157:H7 str. Sakai 916416 NP_311783.1 CDS ECs3756 NC_002695.1 3763916 3765235 D Catalyzes the deamination of guanine; guanine deaminase 3763916..3765235 Escherichia coli O157:H7 str. Sakai 916417 NP_311784.1 CDS ECs3757 NC_002695.1 3765271 3766638 D similar to YGFQ_ECOLI gi|1789250, YGFR_ECOLI gi|1789251; oxidoreductase 3765271..3766638 Escherichia coli O157:H7 str. Sakai 916418 NP_311785.1 CDS ECs3758 NC_002695.1 3766674 3767069 R similar to YGFS_ECOLI gi|1789252; oxidoreductase Fe-S subunit complement(3766674..3767069) Escherichia coli O157:H7 str. Sakai 916420 NP_311786.1 CDS ECs3759 NC_002695.1 3767162 3769096 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(3767162..3769096) Escherichia coli O157:H7 str. Sakai 916422 NP_311787.1 CDS ECs3760 NC_002695.1 3769448 3770965 D similar to YGFU_ECOLI gi|1789254 (conserved in Escherichia coli K-12); permease 3769448..3770965 Escherichia coli O157:H7 str. Sakai 916405 NP_311788.1 CDS ECs3761 NC_002695.1 3771215 3771763 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3771215..3771763 Escherichia coli O157:H7 str. Sakai 916410 NP_311789.1 CDS lysS NC_002695.1 3771806 3773323 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3771806..3773323) Escherichia coli O157:H7 str. Sakai 916412 NP_311790.1 CDS prfB NC_002695.1 3773333 3774431 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3773333..3774355,3774357..3774431)) Escherichia coli O157:H7 str. Sakai 916415 NP_311791.1 CDS ECs3764 NC_002695.1 3774522 3776255 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3774522..3776255) Escherichia coli O157:H7 str. Sakai 916414 NP_311792.1 CDS ECs3765 NC_002695.1 3776261 3776971 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3776261..3776971) Escherichia coli O157:H7 str. Sakai 916411 NP_311793.1 CDS xerD NC_002695.1 3776996 3777892 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3776996..3777892) Escherichia coli O157:H7 str. Sakai 912431 NP_311794.1 CDS ECs3767 NC_002695.1 3778004 3778525 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3778004..3778525 Escherichia coli O157:H7 str. Sakai 913012 NP_311795.1 CDS ECs3768 NC_002695.1 3778565 3778972 R similar to B2896_ECOLI gi|1789263 (conserved in Escherichia coli K-12); hypothetical protein complement(3778565..3778972) Escherichia coli O157:H7 str. Sakai 916350 NP_311796.1 CDS ECs3769 NC_002695.1 3778953 3779219 R similar to YGFY_ECOLI gi|1789264 (conserved in Escherichia coli K-12); hypothetical protein complement(3778953..3779219) Escherichia coli O157:H7 str. Sakai 916353 NP_311797.1 CDS ECs3770 NC_002695.1 3779462 3780442 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3779462..3780442 Escherichia coli O157:H7 str. Sakai 916392 NP_311798.1 CDS ECs3771 NC_002695.1 3780519 3781178 R similar to B2899_ECOLI gi|1789266 (conserved in Escherichia coli K-12); oxidoreductase complement(3780519..3781178) Escherichia coli O157:H7 str. Sakai 916413 NP_311799.1 CDS ECs3772 NC_002695.1 3781342 3781653 R similar to YQFB_ECOLI gi|1789267 (conserved in Escherichia coli K-12); hypothetical protein complement(3781342..3781653) Escherichia coli O157:H7 str. Sakai 916409 NP_311800.1 CDS ECs3773 NC_002695.1 3781692 3783131 D similar to BGLA_ECOLI gi|2367174 (conserved in Escherichia coli K-12); 6-phospho-beta-glucosidase 3781692..3783131 Escherichia coli O157:H7 str. Sakai 916408 NP_311801.1 CDS ECs3774 NC_002695.1 3783297 3786170 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3783297..3786170) Escherichia coli O157:H7 str. Sakai 916407 NP_311802.1 CDS ECs3775 NC_002695.1 3786288 3786677 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3786288..3786677) Escherichia coli O157:H7 str. Sakai 916406 NP_311803.1 CDS gcvT NC_002695.1 3786701 3787795 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3786701..3787795) Escherichia coli O157:H7 str. Sakai 916404 NP_311804.1 CDS ECs3777 NC_002695.1 3788243 3789445 R similar to VISC_ECOLI gi|1789273 (conserved in Escherichia coli K-12); hypothetical protein complement(3788243..3789445) Escherichia coli O157:H7 str. Sakai 916403 NP_311805.1 CDS ECs3778 NC_002695.1 3789469 3790647 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3789469..3790647) Escherichia coli O157:H7 str. Sakai 916402 NP_311806.1 CDS ECs3779 NC_002695.1 3790644 3791969 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3790644..3791969) Escherichia coli O157:H7 str. Sakai 916398 NP_311807.3 CDS ECs3780 NC_002695.1 3791995 3792573 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3791995..3792573) Escherichia coli O157:H7 str. Sakai 916399 NP_311808.1 CDS ECs3781 NC_002695.1 3792741 3793070 D similar to YGFE_ECOLI gi|1789277 (conserved in Escherichia coli K-12); Z-ring-associated protein 3792741..3793070 Escherichia coli O157:H7 str. Sakai 916400 NP_311809.3 CDS ECs3782 NC_002695.1 3793370 3793918 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3793370..3793918 Escherichia coli O157:H7 str. Sakai 916397 NP_311810.1 CDS ECs3783 NC_002695.1 3794091 3794321 R hypothetical protein complement(3794091..3794321) Escherichia coli O157:H7 str. Sakai 916396 NP_311811.1 CDS ECs3784 NC_002695.1 3794700 3795932 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3794700..3795932) Escherichia coli O157:H7 str. Sakai 916388 NP_311812.1 CDS ECs3785 NC_002695.1 3796187 3796846 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3796187..3796846) Escherichia coli O157:H7 str. Sakai 916389 NP_311813.1 CDS ECs3786 NC_002695.1 3797229 3798122 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3797229..3798122 Escherichia coli O157:H7 str. Sakai 916391 NP_311814.1 CDS ECs3787 NC_002695.1 3798326 3800470 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3798326..3800470 Escherichia coli O157:H7 str. Sakai 916393 NP_311815.1 CDS ECs3788 NC_002695.1 3800463 3801458 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3800463..3801458 Escherichia coli O157:H7 str. Sakai 916395 NP_311816.2 CDS ECs3789 NC_002695.1 3801469 3802254 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3801469..3802254 Escherichia coli O157:H7 str. Sakai 916394 NP_311817.1 CDS ECs3790 NC_002695.1 3802278 3803756 D similar to YGFH_ECOLI gi|1789287 (conserved in Escherichia coli K-12); coenzyme A transferase 3802278..3803756 Escherichia coli O157:H7 str. Sakai 916546 NP_311820.1 CDS ECs3793 NC_002695.1 3804816 3805556 R similar to YGGE_ECOLI gi|1789289 (conserved in Escherichia coli K-12); hypothetical protein complement(3804816..3805556) Escherichia coli O157:H7 str. Sakai 916387 NP_311821.1 CDS ECs3794 NC_002695.1 3805649 3806284 R Involved in the export of arginine; arginine exporter protein complement(3805649..3806284) Escherichia coli O157:H7 str. Sakai 916374 NP_311822.1 CDS ECs3795 NC_002695.1 3806423 3807283 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3806423..3807283) Escherichia coli O157:H7 str. Sakai 916375 NP_311823.1 CDS ECs3796 NC_002695.1 3807641 3808720 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3807641..3808720) Escherichia coli O157:H7 str. Sakai 916381 NP_311824.1 CDS pgk NC_002695.1 3808935 3810098 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3808935..3810098) Escherichia coli O157:H7 str. Sakai 916382 NP_311825.1 CDS ECs3798 NC_002695.1 3810148 3811167 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3810148..3811167) Escherichia coli O157:H7 str. Sakai 916383 NP_311826.1 CDS ECs3799 NC_002695.1 3811539 3811970 D similar to hypothetical protein [Methanobacterium thermoautotrophicum] gi|7482365|pir||D69031; hypothetical protein 3811539..3811970 Escherichia coli O157:H7 str. Sakai 916385 NP_311827.1 CDS ECs3800 NC_002695.1 3811993 3812571 D similar to probable low-affinity inorganic phosphate transporter [Mycobacterium tuberculosis] gi|7387993|sp|O06411|PIT_MYCTU, hypothetical protein [Plasmid pNZ4000] gi|5123516|gb|AAD40355.1|; transporter 3811993..3812571 Escherichia coli O157:H7 str. Sakai 916384 NP_311828.1 CDS ECs3801 NC_002695.1 3812572 3813279 D similar to hypothetical protein [Plasmid pNZ4000] gi|5123517|gb|AAD40356.1|; lipoprotein 3812572..3813279 Escherichia coli O157:H7 str. Sakai 916380 NP_311829.1 CDS ECs3802 NC_002695.1 3813267 3813944 D similar to ABC transporter ATP-binding proteins e.g. cation ABC transporter (ATP-binding protein) homolog ykoD [Bacillus subtilis] gi|7445788|pir||H69858; ABC transporter ATP-binding protein 3813267..3813944 Escherichia coli O157:H7 str. Sakai 916379 NP_311830.1 CDS ECs3803 NC_002695.1 3813938 3814615 D similar to ABC transporter ATP-binding proteins e.g. PotA homolog [Agrobacterium rhizogenes plasmid pRi1724] gi|8918682|dbj|BAA97747.1|, [plasmid pNZ4000] gi|512351; ABC transporter ATP-binding protein 3813938..3814615 Escherichia coli O157:H7 str. Sakai 916378 NP_311831.1 CDS frcK NC_002695.1 3814587 3815300 R similar to YGGC_ECOLI gi|1789296, kinase-like protein FrcK [Sinorhizobium meliloti] dad|AF196574-5|AAG28501.1; fructose transport system kinase complement(3814587..3815300) Escherichia coli O157:H7 str. Sakai 916377 NP_311832.1 CDS ECs3805 NC_002695.1 3815297 3815806 R similar to YGGD_ECOLI gi|1789297 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator complement(3815297..3815806) Escherichia coli O157:H7 str. Sakai 916376 NP_311833.1 CDS ECs3806 NC_002695.1 3815828 3816793 R similar to YGGF_ECOLI gi|1789298 (conserved in Escherichia coli K-12); fructose-1,6-bisphosphatase II-like protein complement(3815828..3816793) Escherichia coli O157:H7 str. Sakai 916370 NP_311834.1 CDS ECs3807 NC_002695.1 3816790 3818067 R similar to YGGP_ECOLI gi|1789300, B2931_ECOLI similar to gi|1789299; oxidoreductase complement(3816790..3818067) Escherichia coli O157:H7 str. Sakai 916371 NP_311835.1 CDS ECs3808 NC_002695.1 3818082 3819470 R similar to CMTA_ECOLI gi|1789301 (conserved in Escherichia coli K-12); mannitol-specific PTS system enzyme II component complement(3818082..3819470) Escherichia coli O157:H7 str. Sakai 916373 NP_311836.1 CDS cmtB NC_002695.1 3819498 3819941 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA complement(3819498..3819941) Escherichia coli O157:H7 str. Sakai 916372 NP_311837.1 CDS ECs3810 NC_002695.1 3820255 3822246 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3820255..3822246) Escherichia coli O157:H7 str. Sakai 916368 NP_311838.2 CDS ECs3811 NC_002695.1 3822524 3823282 D similar to YGGG_ECOLI gi|1789305 (conserved in Escherichia coli K-12); hypothetical protein 3822524..3823282 Escherichia coli O157:H7 str. Sakai 916362 NP_311839.1 CDS ECs3812 NC_002695.1 3823488 3824408 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3823488..3824408) Escherichia coli O157:H7 str. Sakai 916365 NP_311840.1 CDS ECs3813 NC_002695.1 3824544 3825275 R lipoprotein complement(3824544..3825275) Escherichia coli O157:H7 str. Sakai 916367 NP_311841.1 CDS ECs3814 NC_002695.1 3825421 3827397 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3825421..3827397) Escherichia coli O157:H7 str. Sakai 916366 NP_311842.1 CDS ECs3815 NC_002695.1 3827406 3827552 R similar to YQGB_ECOLI gi|1789308 (conserved in Escherichia coli K-12); hypothetical protein complement(3827406..3827552) Escherichia coli O157:H7 str. Sakai 916363 NP_311843.1 CDS ECs3816 NC_002695.1 3827673 3827888 D similar to YQGC_ECOLI gi|1789309 (conserved in Escherichia coli K-12); hypothetical protein 3827673..3827888 Escherichia coli O157:H7 str. Sakai 916361 NP_311844.1 CDS ECs3817 NC_002695.1 3827885 3828136 R similar to YQGD_ECOLI gi|1789310 (conserved in Escherichia coli K-12); hypothetical protein complement(3827885..3828136) Escherichia coli O157:H7 str. Sakai 916369 NP_311845.1 CDS ECs3818 NC_002695.1 3828192 3829346 D methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3828192..3829346 Escherichia coli O157:H7 str. Sakai 916356 NP_311846.1 CDS ECs3819 NC_002695.1 3829783 3831177 D similar to GALP_ECOLI gi|1789312 (conserved in Escherichia coli K-12); galactose-proton symport of transport system 3829783..3831177 Escherichia coli O157:H7 str. Sakai 916357 NP_311847.1 CDS ECs3820 NC_002695.1 3831254 3831751 D similar to SPRT_ECOLI gi|1789313 (conserved in Escherichia coli K-12); hypothetical protein 3831254..3831751 Escherichia coli O157:H7 str. Sakai 916358 NP_311848.1 CDS ECs3821 NC_002695.1 3831846 3832553 D similar to ENDA_ECOLI gi|1789314 (conserved in Escherichia coli K-12); DNA-specific endonuclease I 3831846..3832553 Escherichia coli O157:H7 str. Sakai 916360 NP_311849.2 CDS ECs3822 NC_002695.1 3832633 3833364 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3832633..3833364 Escherichia coli O157:H7 str. Sakai 916359 NP_311850.1 CDS ECs3823 NC_002695.1 3833377 3834324 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3833377..3834324 Escherichia coli O157:H7 str. Sakai 916355 NP_311851.2 CDS ECs3824 NC_002695.1 3834436 3834999 D similar to YQGE_ECOLI gi|1789317 (conserved in Escherichia coli K-12); hypothetical protein 3834436..3834999 Escherichia coli O157:H7 str. Sakai 916451 NP_311852.1 CDS ECs3825 NC_002695.1 3834999 3835415 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3834999..3835415 Escherichia coli O157:H7 str. Sakai 916455 NP_311853.1 CDS ECs3827 NC_002695.1 3835606 3836631 R similar to YGGR_ECOLI gi|1789320 (conserved in Escherichia coli K-12); protein transport complement(3835606..3836631) Escherichia coli O157:H7 str. Sakai 916354 NP_311854.1 CDS ECs3826 NC_002695.1 3836604 3837308 D similar to YGGS_ECOLI gi|1789321 (conserved in Escherichia coli K-12); hypothetical protein 3836604..3837308 Escherichia coli O157:H7 str. Sakai 916352 NP_311855.1 CDS ECs3828 NC_002695.1 3837326 3837892 D similar to YGGT_ECOLI gi|1789322 (conserved in Escherichia coli K-12); resistance protein 3837326..3837892 Escherichia coli O157:H7 str. Sakai 916342 NP_311856.2 CDS ECs3829 NC_002695.1 3837889 3838179 D similar to YGGU_ECOLI gi|1789323 (conserved in Escherichia coli K-12); hypothetical protein 3837889..3838179 Escherichia coli O157:H7 str. Sakai 916346 NP_311857.1 CDS ECs3830 NC_002695.1 3838187 3838780 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3838187..3838780 Escherichia coli O157:H7 str. Sakai 916347 NP_311858.1 CDS ECs3831 NC_002695.1 3838773 3839909 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3838773..3839909 Escherichia coli O157:H7 str. Sakai 916351 NP_311859.1 CDS ECs3832 NC_002695.1 3840152 3841159 R similar to YGGM_ECOLI gi|1789326 (conserved in Escherichia coli K-12); hypothetical protein complement(3840152..3841159) Escherichia coli O157:H7 str. Sakai 912996 NP_311860.1 CDS ansB NC_002695.1 3841276 3842322 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3841276..3842322) Escherichia coli O157:H7 str. Sakai 916327 NP_311861.1 CDS ECs3834 NC_002695.1 3842498 3843217 R similar to YGGN_ECOLI gi|1789328 (conserved in Escherichia coli K-12); hypothetical protein complement(3842498..3843217) Escherichia coli O157:H7 str. Sakai 916337 NP_311862.2 CDS ECs3835 NC_002695.1 3843401 3843727 R similar to YGGL_ECOLI gi|1789329 (conserved in Escherichia coli K-12); hypothetical protein complement(3843401..3843727) Escherichia coli O157:H7 str. Sakai 916340 NP_311863.1 CDS trmB NC_002695.1 3843727 3844446 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3843727..3844446) Escherichia coli O157:H7 str. Sakai 916348 NP_311864.1 CDS ECs3837 NC_002695.1 3844607 3845659 D similar to MUTY_ECOLI gi|1789331 (conserved in Escherichia coli K-12); adenine DNA glycosylase 3844607..3845659 Escherichia coli O157:H7 str. Sakai 916345 NP_311865.1 CDS ECs3838 NC_002695.1 3845687 3845962 D similar to YGGX_ECOLI gi|1789332 (conserved in Escherichia coli K-12); hypothetical protein 3845687..3845962 Escherichia coli O157:H7 str. Sakai 916344 NP_311866.1 CDS mltC NC_002695.1 3846024 3847106 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3846024..3847106 Escherichia coli O157:H7 str. Sakai 916343 NP_311867.2 CDS ECs3840 NC_002695.1 3847308 3848564 D transport of nucleosides; permease; similar to NUPG_ECOLI gi|1789336 (conserved in Escherichia coli K-12); protein NupG 3847308..3848564 Escherichia coli O157:H7 str. Sakai 916341 NP_311868.2 CDS ECs3841 NC_002695.1 3848614 3850749 R similar to SPEC_ECOLI gi|1789337 (conserved in Escherichia coli K-12); ornithine decarboxylase complement(3848614..3850749) Escherichia coli O157:H7 str. Sakai 916339 NP_311869.1 CDS ECs3842 NC_002695.1 3851147 3851854 D similar to YQGA_ECOLI gi|1789338 (conserved in Escherichia coli K-12); transporter 3851147..3851854 Escherichia coli O157:H7 str. Sakai 916333 NP_311870.1 CDS ECs3843 NC_002695.1 3852233 3853498 D similar to integrases e.g. [prophage P4] gi|6179516|emb|CAB59974.1; integrase 3852233..3853498 Escherichia coli O157:H7 str. Sakai 916338 NP_311873.1 CDS ECs3846 NC_002695.1 3854489 3855163 D similar to hypothetical proteins e.g. ORF29 [Escherichia coli plasmid pB171] gi|6009405|dbj|BAA84864.1; hypothetical protein 3854489..3855163 Escherichia coli O157:H7 str. Sakai 916331 NP_311874.1 CDS ECs3847 NC_002695.1 3855160 3855507 D similar to hypothetical proteins e.g. ORF30 [Escherichia coli plasmid pB171] gi|6009406|dbj|BAA84865.1; hypothetical protein 3855160..3855507 Escherichia coli O157:H7 str. Sakai 916332 NP_311875.1 CDS ECs3848 NC_002695.1 3855527 3856975 D similar to hypothetical proteins e.g. ORF31 [Escherichia coli plasmid pB171] gi|6009427|dbj|BAA84886.1; hypothetical protein 3855527..3856975 Escherichia coli O157:H7 str. Sakai 916330 NP_311876.1 CDS ECs3849 NC_002695.1 3856776 3857720 R similar to hypothetical protein [Salmonella choleraesuis] gi|7467227|pir||T28668; hypothetical protein complement(3856776..3857720) Escherichia coli O157:H7 str. Sakai 916329 NP_311877.1 CDS ECs3850 NC_002695.1 3857829 3858377 R similar to virulence-related membrane proteins e.g. pagC [Salmonella typhimurium] gi|129558|sp|P23988|PAGC_SALTY; virulence-related membrane protein complement(3857829..3858377) Escherichia coli O157:H7 str. Sakai 916326 NP_311879.1 CDS ECs3852 NC_002695.1 3858950 3859150 R similar to hypothetical proteins e.g. FhaB [Neisseria meningitidis] gi|6900333|emb|CAB71945.1|; hypothetical protein complement(3858950..3859150) Escherichia coli O157:H7 str. Sakai 916324 NP_311881.1 CDS ECs3854 NC_002695.1 3860922 3861149 D similar to KfaE [Escherichia coli] gi|628752|pir||S45104; hypothetical protein 3860922..3861149 Escherichia coli O157:H7 str. Sakai 916321 NP_944561.1 CDS ECs5518 NC_002695.1 3861082 3861276 R hypothetical protein complement(3861082..3861276) Escherichia coli O157:H7 str. Sakai 2693747 NP_311882.1 CDS ECs3855 NC_002695.1 3861357 3863006 D similar to ShET2 enterotoxin [Shigella flexneri] gi|1109754|emb|CAA90938.1|, hypothetical proteins e.g. ankyrilike regulatory protein [Escherichia coli] gi|418526|sp|P2; enterotoxin 3861357..3863006 Escherichia coli O157:H7 str. Sakai 916322 NP_311884.1 CDS ECs3857 NC_002695.1 3863614 3864603 D similar to hypothetical protein [Salmonella typhimurium] gi|6960367|gb|AAF33527.1; hypothetical protein 3863614..3864603 Escherichia coli O157:H7 str. Sakai 916317 NP_311885.1 CDS ECs3858 NC_002695.1 3864652 3865326 D hypothetical protein 3864652..3865326 Escherichia coli O157:H7 str. Sakai 916318 NP_311886.1 CDS ECs3859 NC_002695.1 3865761 3866549 D similar to hypothetical proteins in insertion elements e.g. [IS630] gi|140943|sp|P16943|YIS5_SHISO; hypothetical protein 3865761..3866549 Escherichia coli O157:H7 str. Sakai 916319 NP_311889.1 CDS ECs3862 NC_002695.1 3869375 3870265 R OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 IS629] gi|7443862|pir||T00240; transposase complement(3869375..3870265) Escherichia coli O157:H7 str. Sakai 916313 NP_311890.1 CDS ECs3863 NC_002695.1 3870262 3870588 R OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 IS629] gi|7444868|pir||T00241, hypothetical proteins in insertion sequences e.g. [Shigella flexneri] gi|5532454|gb|AAD44738.1|AF141323_9; transposase complement(3870262..3870588) Escherichia coli O157:H7 str. Sakai 916312 NP_311891.1 CDS ECs3864 NC_002695.1 3870594 3870710 R hypothetical protein complement(3870594..3870710) Escherichia coli O157:H7 str. Sakai 916311 NP_311892.1 CDS ECs3865 NC_002695.1 3870779 3871126 D similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933] gi|3414882|gb|AAC31493.1|; hypothetical protein 3870779..3871126 Escherichia coli O157:H7 str. Sakai 916309 NP_311893.1 CDS ECs3866 NC_002695.1 3871323 3872714 D similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 3871323..3872714 Escherichia coli O157:H7 str. Sakai 916310 NP_311895.1 CDS ECs3868 NC_002695.1 3872937 3873287 D similar to hypothetical proteins e.g. ORF50 [Escherichia coli plasmid pB171] gi|6009426|dbj|BAA84885.1|; hypothetical protein 3872937..3873287 Escherichia coli O157:H7 str. Sakai 916306 NP_311896.1 CDS ECs3869 NC_002695.1 3873500 3874903 D similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 3873500..3874903 Escherichia coli O157:H7 str. Sakai 916299 NP_311898.1 CDS ECs3871 NC_002695.1 3875222 3875566 D similar to hypothetical proteins e.g. L0004 [Escherichia coli O157:H7 strain EDL933] gi|3414872|gb|AAC31483.1|, transposase [Vibrio cholerae] gi|7960026|gb|AAF71186.1|AF179596_6; hypothetical protein 3875222..3875566 Escherichia coli O157:H7 str. Sakai 916297 NP_311899.1 CDS ECs3872 NC_002695.1 3875409 3876725 R similar to PITB_ECOLI gi|1789360; low-affinity phosphate transport protein complement(3875409..3876725) Escherichia coli O157:H7 str. Sakai 916303 NP_311900.1 CDS ECs3873 NC_002695.1 3877017 3878876 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3877017..3878876) Escherichia coli O157:H7 str. Sakai 916304 NP_311901.2 CDS ECs3874 NC_002695.1 3879081 3879947 D YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase 3879081..3879947 Escherichia coli O157:H7 str. Sakai 916302 NP_311902.1 CDS ECs3875 NC_002695.1 3880070 3880318 R similar to HYBG_ECOLI gi|1789364 (conserved in Escherichia coli K-12); hydrogenase 2 accessory protein HypG complement(3880070..3880318) Escherichia coli O157:H7 str. Sakai 916301 NP_311903.1 CDS hypA NC_002695.1 3880331 3880672 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3880331..3880672) Escherichia coli O157:H7 str. Sakai 916300 NP_311904.1 CDS ECs3877 NC_002695.1 3880665 3881153 R similar to HYBE_ECOLI gi|1789366 (conserved in Escherichia coli K-12); hydrogenase 2-specific chaperone complement(3880665..3881153) Escherichia coli O157:H7 str. Sakai 916298 NP_311905.1 CDS hybD NC_002695.1 3881146 3881640 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3881146..3881640) Escherichia coli O157:H7 str. Sakai 916296 NP_311906.1 CDS ECs3879 NC_002695.1 3881640 3883343 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3881640..3883343) Escherichia coli O157:H7 str. Sakai 916295 NP_311907.1 CDS ECs3880 NC_002695.1 3883340 3884518 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit complement(3883340..3884518) Escherichia coli O157:H7 str. Sakai 916282 NP_311908.1 CDS ECs3881 NC_002695.1 3884508 3885494 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3884508..3885494) Escherichia coli O157:H7 str. Sakai 916288 NP_311909.1 CDS ECs3882 NC_002695.1 3885497 3886615 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3885497..3886615) Escherichia coli O157:H7 str. Sakai 916289 NP_311910.1 CDS ECs3883 NC_002695.1 3886804 3887091 R similar to B2998_ECOLI gi|1789372 (conserved in Escherichia coli K-12); hypothetical protein complement(3886804..3887091) Escherichia coli O157:H7 str. Sakai 916292 NP_311911.1 CDS ECs3884 NC_002695.1 3887210 3888097 R similar to B3000_ECOLI gi|1789374, B2999_ECOLI gi|1789373; hypothetical protein complement(3887210..3888097) Escherichia coli O157:H7 str. Sakai 916294 NP_311912.1 CDS ECs3885 NC_002695.1 3888254 3889294 D similar to B3001_ECOLI gi|1789375 (conserved in Escherichia coli K-12); aldo/keto reductase 3888254..3889294 Escherichia coli O157:H7 str. Sakai 916499 NP_311913.1 CDS ECs3886 NC_002695.1 3889334 3889828 R similar to YQHA_ECOLI gi|1789376 (conserved in Escherichia coli K-12); hypothetical protein complement(3889334..3889828) Escherichia coli O157:H7 str. Sakai 916291 NP_311914.1 CDS ECs3887 NC_002695.1 3890019 3890903 D similar to YGHA_ECOLI gi|1789378 (conserved in Escherichia coli K-12); oxidoreductase 3890019..3890903 Escherichia coli O157:H7 str. Sakai 916290 NP_311915.1 CDS ECs3888 NC_002695.1 3891079 3891324 D similar to B3004_ECOLI gi|1789379 (conserved in Escherichia coli K-12); hypothetical protein 3891079..3891324 Escherichia coli O157:H7 str. Sakai 916286 NP_311916.1 CDS ECs3889 NC_002695.1 3891175 3891600 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3891175..3891600) Escherichia coli O157:H7 str. Sakai 916285 NP_311917.1 CDS ECs3890 NC_002695.1 3891607 3892341 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3891607..3892341) Escherichia coli O157:H7 str. Sakai 916284 NP_311918.1 CDS ECs3891 NC_002695.1 3892334 3892489 R similar to B3007_ECOLI gi|1789382 (conserved in Escherichia coli K-12); hypothetical protein complement(3892334..3892489) Escherichia coli O157:H7 str. Sakai 916283 NP_311919.1 CDS ECs3892 NC_002695.1 3892593 3893780 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3892593..3893780 Escherichia coli O157:H7 str. Sakai 916277 NP_311920.1 CDS ECs3893 NC_002695.1 3893920 3894579 D similar to YGHB_ECOLI gi|1789384 (conserved in Escherichia coli K-12); hypothetical protein 3893920..3894579 Escherichia coli O157:H7 str. Sakai 916278 NP_311921.2 CDS ECs3895 NC_002695.1 3894619 3895575 R similar to YQHC_ECOLI gi|1789385 (conserved in Escherichia coli K-12); AraC family transcriptional regulator complement(3894619..3895575) Escherichia coli O157:H7 str. Sakai 916280 NP_311922.1 CDS ECs3894 NC_002695.1 3895712 3896875 D similar to YQHD_ECOLI gi|1789386 (conserved in Escherichia coli K-12); oxidoreductase 3895712..3896875 Escherichia coli O157:H7 str. Sakai 916281 NP_311923.2 CDS dkgA NC_002695.1 3896980 3897807 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3896980..3897807 Escherichia coli O157:H7 str. Sakai 916279 NP_311924.1 CDS ECs3897 NC_002695.1 3898007 3898282 D similar to N-terminal part of YQHG_ECOLI gi|2367185; hypothetical protein 3898007..3898282 Escherichia coli O157:H7 str. Sakai 916488 NP_311925.1 CDS ECs3898 NC_002695.1 3898276 3898929 D similar to C-terminal part of YQHG_ECOLI gi|2367185; hypothetical protein 3898276..3898929 Escherichia coli O157:H7 str. Sakai 916492 NP_311926.1 CDS ECs3899 NC_002695.1 3898978 3899235 D similar to YQHH_ECOLI gi|1789390 (conserved in Escherichia coli K-12); outer membrane lipoprotein 3898978..3899235 Escherichia coli O157:H7 str. Sakai 916271 NP_311927.1 CDS ECs3900 NC_002695.1 3899278 3901497 R similar to YGIR_ECOLI similar to gi|1789392, B3015_ECOLI gi|1789391; hypothetical protein complement(3899278..3901497) Escherichia coli O157:H7 str. Sakai 916273 NP_311928.1 CDS ECs3901 NC_002695.1 3901608 3903020 R similar to SUFI_ECOLI gi|1789394 (conserved in Escherichia coli K-12); repressor protein for FtsI complement(3901608..3903020) Escherichia coli O157:H7 str. Sakai 916275 NP_311929.1 CDS ECs3902 NC_002695.1 3903095 3903832 R similar to PLSC_ECOLI gi|1789395 (conserved in Escherichia coli K-12); 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3903095..3903832) Escherichia coli O157:H7 str. Sakai 916276 NP_311930.1 CDS ECs3903 NC_002695.1 3904066 3906324 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3904066..3906324) Escherichia coli O157:H7 str. Sakai 916274 NP_311931.1 CDS ECs3904 NC_002695.1 3906462 3908069 R YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; hypothetical protein complement(3906462..3908069) Escherichia coli O157:H7 str. Sakai 916272 NP_311932.1 CDS ECs3905 NC_002695.1 3908178 3908660 R similar to B3023_ECOLI gi|1789400 (conserved in Escherichia coli K-12); hypothetical protein complement(3908178..3908660) Escherichia coli O157:H7 str. Sakai 916269 NP_311933.1 CDS ECs3906 NC_002695.1 3908713 3909105 R similar to YGIW_ECOLI gi|1789401 (conserved in Escherichia coli K-12); hypothetical protein complement(3908713..3909105) Escherichia coli O157:H7 str. Sakai 916268 NP_311934.1 CDS ECs3907 NC_002695.1 3909257 3909916 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3909257..3909916 Escherichia coli O157:H7 str. Sakai 916262 NP_311937.1 CDS ECs3910 NC_002695.1 3911371 3911952 D similar to MDAB_ECOLI gi|1789406 (conserved in Escherichia coli K-12); modulator of drug activity B 3911371..3911952 Escherichia coli O157:H7 str. Sakai 916264 NP_311938.1 CDS ECs3911 NC_002695.1 3911983 3912297 D similar to YGIN_ECOLI gi|1789407 (conserved in Escherichia coli K-12); hypothetical protein 3911983..3912297 Escherichia coli O157:H7 str. Sakai 916263 NP_311939.1 CDS ECs3912 NC_002695.1 3912342 3913229 R similar to regulators (RpiR family) e.g. [Bacillus subtilis] gi|8248807|emb|CAB93068.1; transcriptional regulator complement(3912342..3913229) Escherichia coli O157:H7 str. Sakai 916261 NP_311940.1 CDS ECs3913 NC_002695.1 3913226 3914173 R similar to ferrichrome-binding proteins e.g. [Bacillus subtilis] gi|585132|sp|P37580|FHUD_BACSU; ferrichrome-binding protein complement(3913226..3914173) Escherichia coli O157:H7 str. Sakai 916259 NP_311941.1 CDS ECs3914 NC_002695.1 3914184 3915233 R similar to ferrichrome ABC transporter (permease) e.g. [Bacillus subtilis] gi|1706797|sp|P49937|FHUG_BACSU; permease of ferrichrome ABC transporter complement(3914184..3915233) Escherichia coli O157:H7 str. Sakai 916258 NP_311942.1 CDS ECs3915 NC_002695.1 3915230 3916213 R similar to ferrichrome ABC transporters (permease) e.g. [Synechocystis sp.] gi|7442493|pir||S74438, [Bacillus subtilis] gi|1706795|sp|P49936|FHUB_BACSU; permease of ferrichrome ABC transporter complement(3915230..3916213) Escherichia coli O157:H7 str. Sakai 916257 NP_311943.1 CDS ECs3916 NC_002695.1 3916210 3917019 R similar to ABC-type iron-siderophore transport system ATP-binding proteins e.g. [Synechocystis sp.] gi|7442509|pir||S74440; iron-siderophore iron ABC transporter ATP-binding protein complement(3916210..3917019) Escherichia coli O157:H7 str. Sakai 916256 NP_311944.1 CDS ECs3917 NC_002695.1 3917393 3919534 D similar to ferrichrome-iron receptor precursors e.g. gi|7448497|pir||S74457; ferrichrome iron receptor 3917393..3919534 Escherichia coli O157:H7 str. Sakai 916251 NP_311945.1 CDS ECs3918 NC_002695.1 3919598 3921490 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3919598..3921490) Escherichia coli O157:H7 str. Sakai 916252 NP_311946.1 CDS ECs3919 NC_002695.1 3921519 3922100 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase complement(3921519..3922100) Escherichia coli O157:H7 str. Sakai 916254 NP_311947.1 CDS ECs3920 NC_002695.1 3922100 3922927 R similar to ICC_ECOLI gi|1789410 (conserved in Escherichia coli K-12); cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3922100..3922927) Escherichia coli O157:H7 str. Sakai 916255 NP_311948.1 CDS ECs3921 NC_002695.1 3922952 3923374 R similar to YQIB_ECOLI gi|1789411 (conserved in Escherichia coli K-12); hypothetical protein complement(3922952..3923374) Escherichia coli O157:H7 str. Sakai 916253 NP_311949.1 CDS nudF NC_002695.1 3923375 3924004 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase complement(3923375..3924004) Escherichia coli O157:H7 str. Sakai 916244 NP_311950.2 CDS tolC NC_002695.1 3924209 3925690 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3924209..3925690 Escherichia coli O157:H7 str. Sakai 916248 NP_311951.1 CDS ECs3924 NC_002695.1 3925690 3925950 D similar to YGIA_ECOLI gi|1789414 (conserved in Escherichia coli K-12); hypothetical protein 3925690..3925950 Escherichia coli O157:H7 str. Sakai 916249 NP_311952.2 CDS ECs3925 NC_002695.1 3925838 3926509 D similar to YGIB_ECOLI gi|1789415 (conserved in Escherichia coli K-12); hypothetical protein 3925838..3926509 Escherichia coli O157:H7 str. Sakai 916246 NP_311953.1 CDS ECs3926 NC_002695.1 3926515 3927675 D similar to YGIC_ECOLI gi|1789416 (conserved in Escherichia coli K-12); synthetase/amidase 3926515..3927675 Escherichia coli O157:H7 str. Sakai 916245 NP_311954.1 CDS ECs3927 NC_002695.1 3927713 3928528 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3927713..3928528) Escherichia coli O157:H7 str. Sakai 916243 NP_311955.1 CDS ECs3928 NC_002695.1 3928644 3929417 D similar to YGIE_ECOLI gi|1789419 (conserved in Escherichia coli K-12); zinc transporter ZupT 3928644..3929417 Escherichia coli O157:H7 str. Sakai 916247 NP_311956.1 CDS ribB NC_002695.1 3929907 3930560 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3929907..3930560) Escherichia coli O157:H7 str. Sakai 916228 NP_311957.2 CDS ECs3930 NC_002695.1 3930898 3931233 D similar to B3042_ECOLI gi|1789421 (conserved in Escherichia coli K-12); hypothetical protein 3930898..3931233 Escherichia coli O157:H7 str. Sakai 916227 NP_311958.1 CDS ECs3931 NC_002695.1 3931268 3931468 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3931268..3931468) Escherichia coli O157:H7 str. Sakai 916232 NP_311959.1 CDS ECs3932 NC_002695.1 3931737 3932351 D similar to B3050_ECOLI gi|1789429 (conserved in Escherichia coli K-12); oxidoreductase 3931737..3932351 Escherichia coli O157:H7 str. Sakai 916237 NP_311960.1 CDS ECs3933 NC_002695.1 3932393 3934054 D similar to B3051_ECOLI gi|1789430 (conserved in Escherichia coli K-12); hypothetical protein 3932393..3934054 Escherichia coli O157:H7 str. Sakai 916242 NP_311961.1 CDS ECs3934 NC_002695.1 3934389 3934781 D hypothetical protein 3934389..3934781 Escherichia coli O157:H7 str. Sakai 916241 NP_311962.1 CDS ECs3935 NC_002695.1 3934848 3936281 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3934848..3936281) Escherichia coli O157:H7 str. Sakai 916240 NP_311963.1 CDS ECs3936 NC_002695.1 3936329 3939169 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3936329..3939169) Escherichia coli O157:H7 str. Sakai 916239 NP_311964.1 CDS ECs3937 NC_002695.1 3939192 3940493 R similar to YGIF_ECOLI gi|1789434 (conserved in Escherichia coli K-12); hypothetical protein complement(3939192..3940493) Escherichia coli O157:H7 str. Sakai 916238 NP_311965.1 CDS ECs3938 NC_002695.1 3940735 3941355 D similar to YGIM_ECOLI gi|1789435 (conserved in Escherichia coli K-12); signal transduction protein 3940735..3941355 Escherichia coli O157:H7 str. Sakai 916236 NP_311966.1 CDS cca NC_002695.1 3941419 3942657 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3941419..3942657 Escherichia coli O157:H7 str. Sakai 916235 NP_311967.1 CDS uppP NC_002695.1 3942838 3943659 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase complement(3942838..3943659) Escherichia coli O157:H7 str. Sakai 916234 NP_311968.1 CDS folB NC_002695.1 3943750 3944121 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3943750..3944121) Escherichia coli O157:H7 str. Sakai 916233 NP_311969.1 CDS ECs3942 NC_002695.1 3944224 3944841 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3944224..3944841 Escherichia coli O157:H7 str. Sakai 916130 NP_311970.1 CDS ECs3943 NC_002695.1 3944854 3945786 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3944854..3945786) Escherichia coli O157:H7 str. Sakai 916169 NP_311971.1 CDS ECs3944 NC_002695.1 3945993 3946904 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3945993..3946904 Escherichia coli O157:H7 str. Sakai 916192 NP_311972.1 CDS ECs3945 NC_002695.1 3946901 3947506 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3946901..3947506 Escherichia coli O157:H7 str. Sakai 916229 NP_311973.1 CDS ECs3946 NC_002695.1 3947555 3949018 D similar to YGJE_ECOLI gi|1789444 (conserved in Escherichia coli K-12); hypothetical protein 3947555..3949018 Escherichia coli O157:H7 str. Sakai 916226 NP_311974.1 CDS ECs3947 NC_002695.1 3949061 3950074 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(3949061..3950074) Escherichia coli O157:H7 str. Sakai 916225 NP_311975.1 CDS rpsU NC_002695.1 3950312 3950527 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3950312..3950527 Escherichia coli O157:H7 str. Sakai 916223 NP_311976.1 CDS dnaG NC_002695.1 3950638 3952383 D synthesizes RNA primers at the replication forks; DNA primase 3950638..3952383 Escherichia coli O157:H7 str. Sakai 916216 NP_311977.1 CDS ECs3950 NC_002695.1 3952578 3954419 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3952578..3954419 Escherichia coli O157:H7 str. Sakai 916217 NP_311978.1 CDS ECs3951 NC_002695.1 3954498 3955004 R similar to YGJF_ECOLI gi|1789449 (conserved in Escherichia coli K-12); G/U mismatch-specific DNA glycosylase complement(3954498..3955004) Escherichia coli O157:H7 str. Sakai 916221 NP_311979.1 CDS ECs3952 NC_002695.1 3955258 3956022 R similar to YQJH_ECOLI gi|1789450 (conserved in Escherichia coli K-12); hypothetical protein complement(3955258..3956022) Escherichia coli O157:H7 str. Sakai 916220 NP_311980.1 CDS ECs3953 NC_002695.1 3956310 3956933 D similar to YQJI_ECOLI gi|1789452 (conserved in Escherichia coli K-12); hypothetical protein 3956310..3956933 Escherichia coli O157:H7 str. Sakai 916218 NP_311981.1 CDS ECs3954 NC_002695.1 3957087 3958607 R similar to AER_ECOLI gi|1789453 (conserved in Escherichia coli K-12); aerotaxis sensor receptor complement(3957087..3958607) Escherichia coli O157:H7 str. Sakai 916215 NP_311982.2 CDS ECs3955 NC_002695.1 3958998 3960404 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3958998..3960404 Escherichia coli O157:H7 str. Sakai 916214 NP_311983.1 CDS ECs3956 NC_002695.1 3960446 3960778 R similar to YGJH_ECOLI gi|1789455 (conserved in Escherichia coli K-12); hypothetical protein complement(3960446..3960778) Escherichia coli O157:H7 str. Sakai 916206 NP_311984.1 CDS ECs3957 NC_002695.1 3960997 3961980 D similar to EBGR_ECOLI gi|1789456 (conserved in Escherichia coli K-12); DNA-binding transcriptional repressor EbgR 3960997..3961980 Escherichia coli O157:H7 str. Sakai 916208 NP_311985.2 CDS ebgA NC_002695.1 3962164 3965256 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3962164..3965256 Escherichia coli O157:H7 str. Sakai 916211 NP_311986.1 CDS ebgC NC_002695.1 3965253 3965702 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3965253..3965702 Escherichia coli O157:H7 str. Sakai 916212 NP_311987.1 CDS ECs3960 NC_002695.1 3965765 3967198 D similar to YGJI_ECOLI gi|1789459 (conserved in Escherichia coli K-12); oxidoreductase 3965765..3967198 Escherichia coli O157:H7 str. Sakai 916209 NP_311988.1 CDS ECs3961 NC_002695.1 3967332 3968402 D similar to YGJJ_ECOLI gi|1789461 (conserved in Escherichia coli K-12); hypothetical protein 3967332..3968402 Escherichia coli O157:H7 str. Sakai 916207 NP_311989.1 CDS ECs3962 NC_002695.1 3968419 3970770 D similar to YGJK_ECOLI gi|1789462 (conserved in Escherichia coli K-12); glycosyl hydrolase 3968419..3970770 Escherichia coli O157:H7 str. Sakai 916204 NP_311990.1 CDS ECs3963 NC_002695.1 3971296 3973314 D similar to YGJL_ECOLI gi|1789463 (conserved in Escherichia coli K-12); NADPH dehydrogenase 3971296..3973314 Escherichia coli O157:H7 str. Sakai 916198 NP_311991.1 CDS ECs3964 NC_002695.1 3973359 3973775 R similar to YGJM_ECOLI gi|1789464 (conserved in Escherichia coli K-12); hypothetical protein complement(3973359..3973775) Escherichia coli O157:H7 str. Sakai 916199 NP_311992.1 CDS ECs3965 NC_002695.1 3973772 3974086 R similar to YGJN_ECOLI gi|1789465 (conserved in Escherichia coli K-12); hypothetical protein complement(3973772..3974086) Escherichia coli O157:H7 str. Sakai 916202 NP_311993.2 CDS ECs3966 NC_002695.1 3974370 3975506 R similar to YGJO_ECOLI gi|1789466 (conserved in Escherichia coli K-12); hypothetical protein complement(3974370..3975506) Escherichia coli O157:H7 str. Sakai 916203 NP_311994.1 CDS ECs3967 NC_002695.1 3975555 3976094 D similar to YGJP_ECOLI gi|1789467 (conserved in Escherichia coli K-12); hypothetical protein 3975555..3976094 Escherichia coli O157:H7 str. Sakai 916201 NP_311995.1 CDS ECs3968 NC_002695.1 3976171 3976863 D similar to YGJQ_ECOLI gi|1789468 (conserved in Escherichia coli K-12); hypothetical protein 3976171..3976863 Escherichia coli O157:H7 str. Sakai 916200 NP_311996.1 CDS ECs3969 NC_002695.1 3976924 3977928 D similar to YGJR_ECOLI gi|2367190 (conserved in Escherichia coli K-12); hypothetical protein 3976924..3977928 Escherichia coli O157:H7 str. Sakai 916197 NP_311997.1 CDS ECs3970 NC_002695.1 3978212 3979177 D similar to YGJT_ECOLI gi|1789472 (conserved in Escherichia coli K-12); transporter 3978212..3979177 Escherichia coli O157:H7 str. Sakai 916186 NP_311998.1 CDS ECs3971 NC_002695.1 3979576 3980820 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3979576..3980820 Escherichia coli O157:H7 str. Sakai 916190 NP_311999.1 CDS ECs3972 NC_002695.1 3980825 3981376 R similar to YGJV_ECOLI gi|1789474 (conserved in Escherichia coli K-12); hypothetical protein complement(3980825..3981376) Escherichia coli O157:H7 str. Sakai 916194 NP_312000.1 CDS ECs3973 NC_002695.1 3981459 3982946 R similar to UXAA_ECOLI gi|1789475 (conserved in Escherichia coli K-12); altronate hydrolase complement(3981459..3982946) Escherichia coli O157:H7 str. Sakai 916195 NP_312001.1 CDS ECs3974 NC_002695.1 3982961 3984373 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3982961..3984373) Escherichia coli O157:H7 str. Sakai 916193 NP_312002.1 CDS ECs3975 NC_002695.1 3984736 3986154 D similar to EXUT_ECOLI gi|2367193 (conserved in Escherichia coli K-12); hexuronates transport protein 3984736..3986154 Escherichia coli O157:H7 str. Sakai 916191 NP_312003.2 CDS ECs3976 NC_002695.1 3986284 3987060 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3986284..3987060 Escherichia coli O157:H7 str. Sakai 916189 NP_312004.1 CDS ECs3977 NC_002695.1 3987405 3988067 D similar to YQJA_ECOLI gi|1789481 (conserved in Escherichia coli K-12); hypothetical protein 3987405..3988067 Escherichia coli O157:H7 str. Sakai 916188 NP_312005.1 CDS ECs3978 NC_002695.1 3988071 3988454 D similar to YQJB_ECOLI gi|1789482 (conserved in Escherichia coli K-12); hypothetical protein 3988071..3988454 Escherichia coli O157:H7 str. Sakai 916184 NP_312006.2 CDS ECs3979 NC_002695.1 3988601 3988969 D similar to YQJC_ECOLI gi|2367195 (Conserved in E.coli K-q2); hypothetical protein 3988601..3988969 Escherichia coli O157:H7 str. Sakai 916185 NP_312007.1 CDS ECs3980 NC_002695.1 3989007 3989312 D similar to YQJD_ECOLI gi|1789485 (conserved in Escherichia coli K-12); hypothetical protein 3989007..3989312 Escherichia coli O157:H7 str. Sakai 916205 NP_312008.1 CDS ECs3981 NC_002695.1 3989315 3989719 D similar to YQJE_ECOLI gi|1789486 (conserved in Escherichia coli K-12); hypothetical protein 3989315..3989719 Escherichia coli O157:H7 str. Sakai 916196 NP_312009.1 CDS ECs3982 NC_002695.1 3989709 3990008 D similar to B3100_ECOLI gi|1789487 (conserved in Escherichia coli K-12); hypothetical protein 3989709..3990008 Escherichia coli O157:H7 str. Sakai 916210 NP_312010.1 CDS ECs3983 NC_002695.1 3990104 3990586 D similar to YQJF_ECOLI gi|1789488 (conserved in Escherichia coli K-12); hypothetical protein 3990104..3990586 Escherichia coli O157:H7 str. Sakai 916177 NP_312011.1 CDS ECs3984 NC_002695.1 3990656 3991642 D similar to YQJG_ECOLI gi|1789489 (conserved in Escherichia coli K-12); transferase 3990656..3991642 Escherichia coli O157:H7 str. Sakai 916178 NP_312012.1 CDS ECs3985 NC_002695.1 3991934 3992299 D similar to YHAH_ECOLI gi|2367196 (conserved in Escherichia coli K-12); cytochrome 3991934..3992299 Escherichia coli O157:H7 str. Sakai 916181 NP_312013.1 CDS ECs3986 NC_002695.1 3992540 3992896 D similar to YHAI_ECOLI gi|1789491 (conserved in Escherichia coli K-12); cytochrome 3992540..3992896 Escherichia coli O157:H7 str. Sakai 916183 NP_312014.1 CDS ECs3987 NC_002695.1 3992947 3993843 R similar to YHAJ_ECOLI gi|1789492 (conserved in Escherichia coli K-12); LysR family transcriptional regulator complement(3992947..3993843) Escherichia coli O157:H7 str. Sakai 916179 NP_312015.1 CDS ECs3988 NC_002695.1 3993948 3994649 D similar to YHAK_ECOLI gi|1789493 (conserved in Escherichia coli K-12); hypothetical protein 3993948..3994649 Escherichia coli O157:H7 str. Sakai 916176 NP_312016.1 CDS ECs3989 NC_002695.1 3994666 3994836 D similar to YHAL_ECOLI gi|1789494 (conserved in Escherichia coli K-12); hypothetical protein 3994666..3994836 Escherichia coli O157:H7 str. Sakai 916174 NP_312017.1 CDS ECs3990 NC_002695.1 3994970 3996280 R similar to YHAN_ECOLI gi|1789496, YHAM_ECOLI gi|1789495; hypothetical protein complement(3994970..3996280) Escherichia coli O157:H7 str. Sakai 916164 NP_312018.1 CDS ECs3991 NC_002695.1 3996308 3997639 R similar to YHAO_ECOLI gi|1789497 (conserved in Escherichia coli K-12); transport system permease complement(3996308..3997639) Escherichia coli O157:H7 str. Sakai 916166 NP_312019.1 CDS ECs3992 NC_002695.1 3997914 3999278 R similar to YHAQ_ECOLI gi|1789500, YHAP_ECOLI gi|1789498, L-serine deaminase gi|1788116; L-serine deaminase complement(3997914..3999278) Escherichia coli O157:H7 str. Sakai 916172 NP_312020.2 CDS ECs3993 NC_002695.1 3999350 3999739 R similar to YHAR_ECOLI gi|1789501 (conserved in Escherichia coli K-12); hypothetical protein complement(3999350..3999739) Escherichia coli O157:H7 str. Sakai 916173 NP_312021.1 CDS ECs3994 NC_002695.1 3999753 4002047 R similar to TDCE_ECOLI gi|1789502 (conserved in Escherichia coli K-12); formate acetyltransferase 3 complement(3999753..4002047) Escherichia coli O157:H7 str. Sakai 916171 NP_312022.1 CDS ECs3995 NC_002695.1 4002081 4003301 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(4002081..4003301) Escherichia coli O157:H7 str. Sakai 916170 NP_312023.1 CDS ECs3996 NC_002695.1 4003315 4004646 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(4003315..4004646) Escherichia coli O157:H7 str. Sakai 916533 NP_312024.1 CDS ECs3997 NC_002695.1 4004668 4005657 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(4004668..4005657) Escherichia coli O157:H7 str. Sakai 916167 NP_312025.1 CDS ECs3998 NC_002695.1 4005756 4006694 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; TdcA family transcriptional regulator complement(4005756..4006694) Escherichia coli O157:H7 str. Sakai 916165 NP_312026.1 CDS ECs3999 NC_002695.1 4006883 4007227 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; TdcR family transcriptional regulator 4006883..4007227 Escherichia coli O157:H7 str. Sakai 916156 NP_312027.1 CDS ECs4000 NC_002695.1 4007462 4008022 D similar to YHAB_ECOLI gi|1789508 (conserved in Escherichia coli K-12); hypothetical protein 4007462..4008022 Escherichia coli O157:H7 str. Sakai 916153 NP_312028.1 CDS ECs4001 NC_002695.1 4008044 4009231 D similar to YHAC_ECOLI gi|1789509 (conserved in Escherichia coli K-12); hypothetical protein 4008044..4009231 Escherichia coli O157:H7 str. Sakai 916149 NP_312029.2 CDS ECs4002 NC_002695.1 4009860 4011005 R similar to YHAD_ECOLI gi|1789512 (conserved in Escherichia coli K-12); glycerate kinase complement(4009860..4011005) Escherichia coli O157:H7 str. Sakai 916168 NP_312030.2 CDS garR NC_002695.1 4011102 4011992 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(4011102..4011992) Escherichia coli O157:H7 str. Sakai 916157 NP_312031.1 CDS ECs4004 NC_002695.1 4012022 4012792 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(4012022..4012792) Escherichia coli O157:H7 str. Sakai 916159 NP_312032.1 CDS ECs4005 NC_002695.1 4012808 4014142 R similar to YHAU_ECOLI gi|1789515 (conserved in Escherichia coli K-12); transporter complement(4012808..4014142) Escherichia coli O157:H7 str. Sakai 916162 NP_312033.1 CDS ECs4006 NC_002695.1 4014517 4016088 D similar to YHAG_ECOLI gi|1789516 (conserved in Escherichia coli K-12); hydrolase 4014517..4016088 Escherichia coli O157:H7 str. Sakai 916161 NP_312034.1 CDS ECs4007 NC_002695.1 4016237 4016572 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 4016237..4016572 Escherichia coli O157:H7 str. Sakai 916160 NP_312035.1 CDS ECs4008 NC_002695.1 4016572 4017036 D similar to YHAV_ECOLI gi|1789518 (conserved in Escherichia coli K-12); hypothetical protein 4016572..4017036 Escherichia coli O157:H7 str. Sakai 916158 NP_312036.1 CDS ECs4009 NC_002695.1 4017091 4017900 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; AgaR family transcriptional regulator complement(4017091..4017900) Escherichia coli O157:H7 str. Sakai 916155 NP_312037.1 CDS ECs4010 NC_002695.1 4018149 4019429 D similar to KBAZ_ECOLI (strain C) dad|AF228498-2|AAF81082.1 (conserved in Escherichia coli K-12); tagatose 6-phosphate kinase 2 4018149..4019429 Escherichia coli O157:H7 str. Sakai 916154 NP_312038.2 CDS ECs4011 NC_002695.1 4019452 4019925 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4019452..4019925 Escherichia coli O157:H7 str. Sakai 916508 NP_312039.1 CDS ECs4012 NC_002695.1 4019936 4020715 D similar to AGAW_ECOLI (strain C) gi|8895748|gb|AAF81084.1|AF228498_4; N-acetylgalactosamine-specific PTS system enzyme IIC component 4019936..4020715 Escherichia coli O157:H7 str. Sakai 916519 NP_312040.1 CDS ECs4013 NC_002695.1 4020705 4021583 D AgaE; similar to PTS dependent N-acetyl-galactosamine-IID component, AgaE [Escherichia coli strain C] gi|8895749|gb|AAF81085.1|AF228498_5; N-acetylgalactosamine-specific PTS system enzyme IID component 4020705..4021583 Escherichia coli O157:H7 str. Sakai 916505 NP_312041.1 CDS ECs4014 NC_002695.1 4021601 4022035 D AfaF; similar to ts dependent N-acetyl-galactosamine- and galactosamine IIA component, AgaF [Escherichia coli strain C] gi|8895750|gb|AAF81086.1|AF228498_6; N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component 4021601..4022035 Escherichia coli O157:H7 str. Sakai 916152 NP_312042.1 CDS ECs4015 NC_002695.1 4022011 4023165 D similar to AGAA_ECOLI (strain C) gi|8895751|dad|AF228498-7|AAF81087.1; N-acetylgalactosamine-6-phosphate deacetylase 4022011..4023165 Escherichia coli O157:H7 str. Sakai 916151 NP_312043.1 CDS ECs4016 NC_002695.1 4023516 4024670 D similar to AGAS_ECOLI (strain C) dad|AF228498-8|AAF81088.1 (conserved in Escherichia coli K-12); tagatose-6-phosphate aldose/ketose isomerase 4023516..4024670 Escherichia coli O157:H7 str. Sakai 916150 NP_312044.1 CDS kbaY NC_002695.1 4024683 4025543 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 4024683..4025543 Escherichia coli O157:H7 str. Sakai 916148 NP_312045.1 CDS ECs4018 NC_002695.1 4025710 4026186 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4025710..4026186 Escherichia coli O157:H7 str. Sakai 916140 NP_312046.1 CDS ECs4019 NC_002695.1 4027018 4027809 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 4027018..4027809 Escherichia coli O157:H7 str. Sakai 916141 NP_312047.1 CDS ECs4020 NC_002695.1 4028966 4029550 D similar to YRAH_ECOLI gi|1789531 (conserved in Escherichia coli K-12); fimbrial-like protein 4028966..4029550 Escherichia coli O157:H7 str. Sakai 916146 NP_312048.1 CDS ECs4021 NC_002695.1 4029630 4030325 D similar to YRAI_ECOLI gi|1789532 (conserved in Escherichia coli K-12); chaperone 4029630..4030325 Escherichia coli O157:H7 str. Sakai 916145 NP_312049.1 CDS ECs4022 NC_002695.1 4030354 4032870 D similar to YRAJ_ECOLI gi|1789533 (conserved in Escherichia coli K-12); outer membrane protein 4030354..4032870 Escherichia coli O157:H7 str. Sakai 916144 NP_312050.1 CDS ECs4023 NC_002695.1 4032881 4033234 D similar to fimbrial protein YRAK_ECOLI gi|1789534; hypothetical protein 4032881..4033234 Escherichia coli O157:H7 str. Sakai 916142 NP_312051.1 CDS ECs4024 NC_002695.1 4033260 4033586 D OrfA protein of insertion sequence IS629; similar to hypothetical protein gi|7444868|pir||T00241; transposase 4033260..4033586 Escherichia coli O157:H7 str. Sakai 916138 NP_312052.1 CDS ECs4025 NC_002695.1 4033583 4034473 D OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 4033583..4034473 Escherichia coli O157:H7 str. Sakai 916137 NP_312053.1 CDS ECs4026 NC_002695.1 4034457 4034930 D similar to YRAK_ECOLI gi|1789534; fimbrial protein 4034457..4034930 Escherichia coli O157:H7 str. Sakai 916136 NP_312054.1 CDS ECs4027 NC_002695.1 4034973 4035833 R similar to YRAL_ECOLI gi|1789535 (conserved in Escherichia coli K-12); hypothetical protein complement(4034973..4035833) Escherichia coli O157:H7 str. Sakai 916135 NP_312055.1 CDS ECs4028 NC_002695.1 4035898 4037934 D similar to YRAM_ECOLI gi|1789537 (conserved in Escherichia coli K-12); glycosylase 4035898..4037934 Escherichia coli O157:H7 str. Sakai 916134 NP_312056.1 CDS ECs4029 NC_002695.1 4037892 4038287 D similar to YRAN_ECOLI gi|1789538 (conserved in Escherichia coli K-12); hypothetical protein 4037892..4038287 Escherichia coli O157:H7 str. Sakai 916133 NP_312057.1 CDS ECs4030 NC_002695.1 4038307 4038897 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 4038307..4038897 Escherichia coli O157:H7 str. Sakai 916132 NP_312058.1 CDS ECs4031 NC_002695.1 4038907 4039482 D similar to YRAP_ECOLI gi|1789540 (conserved in Escherichia coli K-12); hypothetical protein 4038907..4039482 Escherichia coli O157:H7 str. Sakai 916131 NP_312059.1 CDS ECs4032 NC_002695.1 4039596 4040636 R similar to YRAQ_ECOLI gi|1789541 (conserved in Escherichia coli K-12); hypothetical protein complement(4039596..4040636) Escherichia coli O157:H7 str. Sakai 916129 NP_312060.1 CDS ECs4033 NC_002695.1 4040709 4041389 R similar to YRAR_ECOLI gi|1789542 (conserved in Escherichia coli K-12); hypothetical protein complement(4040709..4041389) Escherichia coli O157:H7 str. Sakai 916128 NP_312061.1 CDS ECs4034 NC_002695.1 4041430 4041990 D similar to YHBO_ECOLI gi|1789543 (conserved in Escherichia coli K-12); hypothetical protein 4041430..4041990 Escherichia coli O157:H7 str. Sakai 916127 NP_312062.1 CDS ECs4035 NC_002695.1 4041970 4042413 R similar to YHBP_ECOLI gi|1789544 (conserved in Escherichia coli K-12); hypothetical protein complement(4041970..4042413) Escherichia coli O157:H7 str. Sakai 916126 NP_312063.1 CDS ECs4036 NC_002695.1 4042464 4042766 D similar to YHBQ_ECOLI gi|1789545 (conserved in Escherichia coli K-12); GIY-YIG nuclease superfamily protein 4042464..4042766 Escherichia coli O157:H7 str. Sakai 916111 NP_312064.1 CDS ECs4037 NC_002695.1 4042753 4043256 R similar to YHBS_ECOLI gi|1789546 (conserved in Escherichia coli K-12); hypothetical protein complement(4042753..4043256) Escherichia coli O157:H7 str. Sakai 916114 NP_312065.1 CDS ECs4038 NC_002695.1 4043250 4043774 R similar to YHBT_ECOLI gi|1789547 (conserved in Escherichia coli K-12); hypothetical protein complement(4043250..4043774) Escherichia coli O157:H7 str. Sakai 916123 NP_312066.1 CDS ECs4039 NC_002695.1 4043983 4044978 D similar to YHBU_ECOLI gi|1789548 (conserved in Escherichia coli K-12); collagenase 4043983..4044978 Escherichia coli O157:H7 str. Sakai 916124 NP_312067.1 CDS ECs4040 NC_002695.1 4044969 4045865 D similar to YHBV_ECOLI gi|1789549 (conserved in Escherichia coli K-12); hypothetical protein 4044969..4045865 Escherichia coli O157:H7 str. Sakai 916122 NP_312068.1 CDS ECs4041 NC_002695.1 4045946 4046953 D similar to YHBW_ECOLI gi|1789551 (conserved in Escherichia coli K-12); hypothetical protein 4045946..4046953 Escherichia coli O157:H7 str. Sakai 916121 NP_312069.1 CDS ECs4042 NC_002695.1 4047070 4048314 R tryptophan transporter of high affinity; tryptophan permease complement(4047070..4048314) Escherichia coli O157:H7 str. Sakai 916120 NP_312070.2 CDS ECs4043 NC_002695.1 4048468 4050357 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(4048468..4050357) Escherichia coli O157:H7 str. Sakai 916119 NP_312071.1 CDS ECs4044 NC_002695.1 4050537 4051421 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; Nlp family transcriptional regulator complement(4050537..4051421) Escherichia coli O157:H7 str. Sakai 916118 NP_312072.1 CDS ECs4045 NC_002695.1 4051530 4053734 R similar to PNP_ECOLI gi|1789555 (conserved in Escherichia coli K-12); polynucleotide phosphorylase complement(4051530..4053734) Escherichia coli O157:H7 str. Sakai 916115 NP_312073.1 CDS rpsO NC_002695.1 4053912 4054181 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(4053912..4054181) Escherichia coli O157:H7 str. Sakai 916113 NP_312074.1 CDS truB NC_002695.1 4054330 4055274 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(4054330..4055274) Escherichia coli O157:H7 str. Sakai 916110 NP_312075.1 CDS rbfA NC_002695.1 4055274 4055675 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(4055274..4055675) Escherichia coli O157:H7 str. Sakai 916109 NP_312076.1 CDS infB NC_002695.1 4055840 4058512 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(4055840..4058512) Escherichia coli O157:H7 str. Sakai 916116 NP_312077.1 CDS nusA NC_002695.1 4058537 4060024 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(4058537..4060024) Escherichia coli O157:H7 str. Sakai 916098 NP_312078.3 CDS ECs4051 NC_002695.1 4060052 4060504 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(4060052..4060504) Escherichia coli O157:H7 str. Sakai 916100 NP_312079.1 CDS ECs4052 NC_002695.1 4061135 4062478 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 4061135..4062478 Escherichia coli O157:H7 str. Sakai 916108 NP_312080.1 CDS ECs4053 NC_002695.1 4062486 4064129 R similar to YHBX_ECOLI gi|1789564 (conserved in Escherichia coli K-12); alkaline phosphatase complement(4062486..4064129) Escherichia coli O157:H7 str. Sakai 916107 NP_312081.1 CDS secG NC_002695.1 4064671 4065003 R protein-export protein; similar to SECG_ECOLI gi|1789565 (conserved in Escherichia coli K-12); preprotein translocase subunit SecG complement(4064671..4065003) Escherichia coli O157:H7 str. Sakai 916105 NP_312082.1 CDS glmM NC_002695.1 4065231 4066568 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(4065231..4066568) Escherichia coli O157:H7 str. Sakai 916104 NP_312083.2 CDS folP NC_002695.1 4066561 4067409 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(4066561..4067409) Escherichia coli O157:H7 str. Sakai 916103 NP_312084.1 CDS hflB NC_002695.1 4067499 4069433 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(4067499..4069433) Escherichia coli O157:H7 str. Sakai 916102 NP_312085.1 CDS rrmJ NC_002695.1 4069533 4070162 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase complement(4069533..4070162) Escherichia coli O157:H7 str. Sakai 916101 NP_312086.1 CDS ECs4059 NC_002695.1 4070288 4070581 D RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 4070288..4070581 Escherichia coli O157:H7 str. Sakai 916097 NP_312087.2 CDS greA NC_002695.1 4070737 4071213 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(4070737..4071213) Escherichia coli O157:H7 str. Sakai 916087 NP_312088.1 CDS ECs4061 NC_002695.1 4071461 4072894 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 4071461..4072894 Escherichia coli O157:H7 str. Sakai 916092 NP_312089.1 CDS obgE NC_002695.1 4072934 4074106 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(4072934..4074106) Escherichia coli O157:H7 str. Sakai 916094 NP_312090.1 CDS ECs4063 NC_002695.1 4074122 4075087 R similar to YHBE_ECOLI gi|1789575 (conserved in Escherichia coli K-12); hypothetical protein complement(4074122..4075087) Escherichia coli O157:H7 str. Sakai 916095 NP_312091.1 CDS rpmA NC_002695.1 4075214 4075471 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(4075214..4075471) Escherichia coli O157:H7 str. Sakai 916093 NP_312092.1 CDS rplU NC_002695.1 4075492 4075803 R similar to RPLU_ECOLI gi|1789577 (conserved in Escherichia coli K-12); 50S ribosomal protein L21 complement(4075492..4075803) Escherichia coli O157:H7 str. Sakai 916091 NP_312093.1 CDS ECs4066 NC_002695.1 4076062 4077033 D similar to ISPB_ECOLI gi|1789578 (conserved in Escherichia coli K-12); octaprenyl diphosphate synthase 4076062..4077033 Escherichia coli O157:H7 str. Sakai 916090 NP_312094.1 CDS ECs4067 NC_002695.1 4077262 4077540 D activator of maltose metabolism genes; Nlp family transcriptional regulator 4077262..4077540 Escherichia coli O157:H7 str. Sakai 916088 NP_312095.1 CDS ECs4068 NC_002695.1 4077588 4078847 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(4077588..4078847) Escherichia coli O157:H7 str. Sakai 916085 NP_312096.1 CDS ECs4069 NC_002695.1 4078902 4079171 R similar to YRBA_ECOLI gi|1789581 (conserved in Escherichia coli K-12); hypothetical protein complement(4078902..4079171) Escherichia coli O157:H7 str. Sakai 916072 NP_312097.2 CDS ECs4070 NC_002695.1 4079316 4079609 R similar to YRBB_ECOLI gi|1789582 (conserved in Escherichia coli K-12); hypothetical protein complement(4079316..4079609) Escherichia coli O157:H7 str. Sakai 916078 NP_312098.1 CDS ECs4071 NC_002695.1 4079609 4080244 R similar to YRBC_ECOLI gi|1789583 (conserved in Escherichia coli K-12); hypothetical protein complement(4079609..4080244) Escherichia coli O157:H7 str. Sakai 916079 NP_312099.1 CDS ECs4072 NC_002695.1 4080263 4080814 R similar to YRBD_ECOLI gi|1789584 (conserved in Escherichia coli K-12); hypothetical protein complement(4080263..4080814) Escherichia coli O157:H7 str. Sakai 916081 NP_312100.1 CDS ECs4073 NC_002695.1 4080819 4081601 R similar to YRBE_ECOLI gi|1789585 (conserved in Escherichia coli K-12); hypothetical protein complement(4080819..4081601) Escherichia coli O157:H7 str. Sakai 916084 NP_312101.1 CDS ECs4074 NC_002695.1 4081609 4082418 R ATP-binding protein of a ABC toluene efflux transporter; ABC transporter ATP-binding protein complement(4081609..4082418) Escherichia coli O157:H7 str. Sakai 916083 NP_312102.1 CDS ECs4075 NC_002695.1 4082628 4083605 D YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 4082628..4083605 Escherichia coli O157:H7 str. Sakai 916082 NP_312103.1 CDS ECs4076 NC_002695.1 4083619 4084605 D similar to YRBH_ECOLI gi|1789588 (conserved in Escherichia coli K-12); D-arabinose 5-phosphate isomerase 4083619..4084605 Escherichia coli O157:H7 str. Sakai 916080 NP_312104.1 CDS ECs4077 NC_002695.1 4084626 4085192 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 4084626..4085192 Escherichia coli O157:H7 str. Sakai 916077 NP_312105.1 CDS ECs4078 NC_002695.1 4085189 4085764 D similar to YRBK_ECOLI gi|1789591 (conserved in Escherichia coli K-12); hypothetical protein 4085189..4085764 Escherichia coli O157:H7 str. Sakai 916076 NP_312106.1 CDS ECs4079 NC_002695.1 4085733 4086290 D LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 4085733..4086290 Escherichia coli O157:H7 str. Sakai 916075 NP_312107.1 CDS ECs4080 NC_002695.1 4086297 4087022 D similar to YHBG_ECOLI gi|1789593 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4086297..4087022 Escherichia coli O157:H7 str. Sakai 916074 NP_312108.1 CDS ECs4081 NC_002695.1 4087070 4088503 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 4087070..4088503 Escherichia coli O157:H7 str. Sakai 916073 NP_312109.1 CDS ECs4082 NC_002695.1 4088526 4088813 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 4088526..4088813 Escherichia coli O157:H7 str. Sakai 916070 NP_312110.1 CDS ECs4083 NC_002695.1 4088931 4089422 D similar to PTSN_ECOLI gi|1789597 (conserved in Escherichia coli K-12); PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 4088931..4089422 Escherichia coli O157:H7 str. Sakai 916068 NP_312111.1 CDS ECs4084 NC_002695.1 4089468 4090322 D similar to YHBJ_ECOLI gi|1789598 (conserved in Escherichia coli K-12); hypothetical protein 4089468..4090322 Escherichia coli O157:H7 str. Sakai 916067 NP_312112.1 CDS ECs4085 NC_002695.1 4090319 4090591 D similar to PTSO_ECOLI gi|1789599 (conserved in Escherichia coli K-12); phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 4090319..4090591 Escherichia coli O157:H7 str. Sakai 916066 NP_312113.1 CDS ECs4086 NC_002695.1 4090805 4091437 D similar to YRBL_ECOLI gi|1789600 (conserved in Escherichia coli K-12); hypothetical protein 4090805..4091437 Escherichia coli O157:H7 str. Sakai 916065 NP_312114.1 CDS mtgA NC_002695.1 4091434 4092162 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(4091434..4092162) Escherichia coli O157:H7 str. Sakai 916064 NP_312115.2 CDS ECs4088 NC_002695.1 4092159 4092812 R similar to YHBL_ECOLI gi|1789602 (conserved in Escherichia coli K-12); isoprenoid biosynthesis protein with amidotransferase-like domain complement(4092159..4092812) Escherichia coli O157:H7 str. Sakai 916063 NP_312116.1 CDS ECs4089 NC_002695.1 4093042 4095378 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(4093042..4095378) Escherichia coli O157:H7 str. Sakai 916062 NP_312117.1 CDS ECs4090 NC_002695.1 4095474 4096403 R similar to YHCC_ECOLI gi|2367204 (conserved in Escherichia coli K-12); hypothetical protein complement(4095474..4096403) Escherichia coli O157:H7 str. Sakai 916061 NP_312118.1 CDS gltB NC_002695.1 4096984 4101537 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 4096984..4101537 Escherichia coli O157:H7 str. Sakai 916060 NP_312119.1 CDS gltD NC_002695.1 4101550 4102968 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 4101550..4102968 Escherichia coli O157:H7 str. Sakai 916059 NP_312120.1 CDS ECs4093 NC_002695.1 4103152 4104201 D similar to YHCG_ECOLI gi|1789614 (conserved in Escherichia coli K-12); hypothetical protein 4103152..4104201 Escherichia coli O157:H7 str. Sakai 916058 NP_312121.1 CDS ECs4094 NC_002695.1 4104261 4104725 R similar to YHCH_ECOLI gi|1789615 (conserved in Escherichia coli K-12); hypothetical protein complement(4104261..4104725) Escherichia coli O157:H7 str. Sakai 916057 NP_312122.2 CDS ECs4095 NC_002695.1 4104722 4105597 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(4104722..4105597) Escherichia coli O157:H7 str. Sakai 916056 NP_312123.1 CDS ECs4096 NC_002695.1 4105594 4106283 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(4105594..4106283) Escherichia coli O157:H7 str. Sakai 916055 NP_312124.2 CDS ECs4097 NC_002695.1 4106331 4107821 R similar to NANT_ECOLI gi|1789618 (conserved in Escherichia coli K-12); sialic acid transporter complement(4106331..4107821) Escherichia coli O157:H7 str. Sakai 916054 NP_312125.1 CDS ECs4098 NC_002695.1 4107930 4108823 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(4107930..4108823) Escherichia coli O157:H7 str. Sakai 916053 NP_312126.2 CDS ECs4099 NC_002695.1 4108945 4109727 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(4108945..4109727) Escherichia coli O157:H7 str. Sakai 916052 NP_312127.1 CDS ECs4100 NC_002695.1 4110116 4111480 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 4110116..4111480 Escherichia coli O157:H7 str. Sakai 916051 NP_312128.1 CDS ECs4101 NC_002695.1 4111515 4112012 R similar to SSPB_ECOLI gi|1789623 (conserved in Escherichia coli K-12); ClpXP protease specificity-enhancing factor complement(4111515..4112012) Escherichia coli O157:H7 str. Sakai 916050 NP_312129.1 CDS sspA NC_002695.1 4112018 4112656 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(4112018..4112656) Escherichia coli O157:H7 str. Sakai 916049 NP_312130.1 CDS rpsI NC_002695.1 4113051 4113443 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(4113051..4113443) Escherichia coli O157:H7 str. Sakai 916048 NP_312131.1 CDS rplM NC_002695.1 4113459 4113887 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(4113459..4113887) Escherichia coli O157:H7 str. Sakai 916047 NP_312132.1 CDS ECs4105 NC_002695.1 4114106 4115233 R similar to YHCM_ECOLI gi|1789627 (conserved in Escherichia coli K-12); hypothetical protein complement(4114106..4115233) Escherichia coli O157:H7 str. Sakai 916046 NP_312133.1 CDS ECs4106 NC_002695.1 4115421 4115825 D similar to YHCB_ECOLI gi|1789628 (conserved in Escherichia coli K-12); cytochrome d ubiquinol oxidase subunit III 4115421..4115825 Escherichia coli O157:H7 str. Sakai 916045 NP_312134.1 CDS ECs4107 NC_002695.1 4115979 4117346 D similar to DEGQ_ECOLI gi|1789629 (conserved in Escherichia coli K-12); serine endoprotease 4115979..4117346 Escherichia coli O157:H7 str. Sakai 916044 NP_312135.1 CDS ECs4108 NC_002695.1 4117436 4118503 D similar to DEGS_ECOLI gi|1789630 (conserved in Escherichia coli K-12); serine endoprotease 4117436..4118503 Escherichia coli O157:H7 str. Sakai 916043 NP_312136.1 CDS ECs4109 NC_002695.1 4118567 4119505 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(4118567..4119505) Escherichia coli O157:H7 str. Sakai 916042 NP_312137.1 CDS ECs4110 NC_002695.1 4119940 4120410 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 4119940..4120410 Escherichia coli O157:H7 str. Sakai 916041 NP_312138.1 CDS ECs4111 NC_002695.1 4120724 4121038 D similar to YHCN_ECOLI gi|1789634 (conserved in Escherichia coli K-12); hypothetical protein 4120724..4121038 Escherichia coli O157:H7 str. Sakai 916040 NP_312139.1 CDS ECs4112 NC_002695.1 4121094 4121366 R similar to YHCO_ECOLI gi|1789635 (conserved in Escherichia coli K-12); hypothetical protein complement(4121094..4121366) Escherichia coli O157:H7 str. Sakai 916038 NP_312140.1 CDS ECs4113 NC_002695.1 4121458 4123425 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(4121458..4123425) Escherichia coli O157:H7 str. Sakai 916037 NP_312141.1 CDS ECs4114 NC_002695.1 4123431 4124360 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(4123431..4124360) Escherichia coli O157:H7 str. Sakai 916117 NP_312142.2 CDS ECs4115 NC_002695.1 4124368 4124571 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(4124368..4124571) Escherichia coli O157:H7 str. Sakai 915547 NP_312143.1 CDS ECs4116 NC_002695.1 4124754 4125683 D similar to YHCS_ECOLI gi|1789639 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 4124754..4125683 Escherichia coli O157:H7 str. Sakai 916027 NP_312144.1 CDS tldD NC_002695.1 4125817 4127262 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(4125817..4127262) Escherichia coli O157:H7 str. Sakai 916036 NP_312145.1 CDS ECs4118 NC_002695.1 4127418 4131218 R similar to YHDR_ECOLI gi|1789643, YHDP_ECOLI similar to gi|2367206; hypothetical protein complement(4127418..4131218) Escherichia coli O157:H7 str. Sakai 916035 NP_312146.1 CDS ECs4119 NC_002695.1 4131286 4132755 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(4131286..4132755) Escherichia coli O157:H7 str. Sakai 916034 NP_312147.1 CDS maf NC_002695.1 4132745 4133338 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(4132745..4133338) Escherichia coli O157:H7 str. Sakai 916033 NP_312148.1 CDS ECs4121 NC_002695.1 4133347 4133835 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(4133347..4133835) Escherichia coli O157:H7 str. Sakai 916032 NP_312149.1 CDS ECs4122 NC_002695.1 4133835 4134938 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(4133835..4134938) Escherichia coli O157:H7 str. Sakai 916031 NP_312150.2 CDS ECs4123 NC_002695.1 4135004 4136047 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(4135004..4136047) Escherichia coli O157:H7 str. Sakai 916030 NP_312151.1 CDS ECs4124 NC_002695.1 4136352 4138292 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(4136352..4138292) Escherichia coli O157:H7 str. Sakai 916029 NP_312152.1 CDS ECs4125 NC_002695.1 4138444 4139418 D similar to YHDH_ECOLI gi|1789651 (conserved in Escherichia coli K-12); dehydrogenase 4138444..4139418 Escherichia coli O157:H7 str. Sakai 916028 NP_312154.1 CDS ECs4127 NC_002695.1 4140396 4140866 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 4140396..4140866 Escherichia coli O157:H7 str. Sakai 916025 NP_312155.1 CDS ECs4128 NC_002695.1 4140877 4142226 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 4140877..4142226 Escherichia coli O157:H7 str. Sakai 916024 NP_312156.1 CDS ECs4129 NC_002695.1 4142335 4142577 D similar to YHDT_ECOLI gi|1789655 (conserved in Escherichia coli K-12); hypothetical protein 4142335..4142577 Escherichia coli O157:H7 str. Sakai 916023 NP_312157.2 CDS panF NC_002695.1 4142567 4144018 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 4142567..4144018 Escherichia coli O157:H7 str. Sakai 916022 NP_312158.1 CDS prmA NC_002695.1 4144030 4144911 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 4144030..4144911 Escherichia coli O157:H7 str. Sakai 916021 NP_312159.1 CDS ECs4132 NC_002695.1 4145240 4146205 D similar to YHDG_ECOLI gi|1789660 (conserved in Escherichia coli K-12); tRNA-dihydrouridine synthase B 4145240..4146205 Escherichia coli O157:H7 str. Sakai 916020 NP_312160.1 CDS fis NC_002695.1 4146231 4146527 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 4146231..4146527 Escherichia coli O157:H7 str. Sakai 916019 NP_312161.2 CDS ECs4134 NC_002695.1 4146612 4147496 D similar to YHDJ_ECOLI gi|1789662 (conserved in Escherichia coli K-12); methyltransferase 4146612..4147496 Escherichia coli O157:H7 str. Sakai 916018 NP_312162.1 CDS ECs4135 NC_002695.1 4147580 4147759 D similar to YHAU_ECOLI gi|1789515 (conserved in Escherichia coli K-12); transporter 4147580..4147759 Escherichia coli O157:H7 str. Sakai 916017 NP_312163.1 CDS ECs4136 NC_002695.1 4147762 4148424 R similar to ENVR_ECOLI gi|1789664 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator EnvR complement(4147762..4148424) Escherichia coli O157:H7 str. Sakai 916016 NP_312164.1 CDS ECs4137 NC_002695.1 4148823 4149980 D similar to ACRE_ECOLI gi|1789665 (conserved in Escherichia coli K-12); transmembrane protein affects septum formation and cell membrane permeability 4148823..4149980 Escherichia coli O157:H7 str. Sakai 916015 NP_312167.1 CDS ECs4140 NC_002695.1 4153394 4153615 D similar to YHAV_ECOLI gi|1789518 (conserved in Escherichia coli K-12); hypothetical protein 4153394..4153615 Escherichia coli O157:H7 str. Sakai 916012 NP_312168.2 CDS ECs4141 NC_002695.1 4154046 4155071 D similar to YHDW_ECOLI gi|1789668 (conserved in Escherichia coli K-12); periplasmic binding transport protein 4154046..4155071 Escherichia coli O157:H7 str. Sakai 916011 NP_312169.2 CDS ECs4142 NC_002695.1 4155139 4156320 D similar to YHDX_ECOLI gi|1789669 (conserved in Escherichia coli K-12); transport system permease 4155139..4156320 Escherichia coli O157:H7 str. Sakai 916010 NP_312170.1 CDS ECs4143 NC_002695.1 4156327 4157433 D similar to YHDY_ECOLI gi|1789671 (conserved in Escherichia coli K-12); transport system permease 4156327..4157433 Escherichia coli O157:H7 str. Sakai 916009 NP_312171.1 CDS ECs4144 NC_002695.1 4157441 4158199 D similar to YHDZ_ECOLI gi|1789672 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4157441..4158199 Escherichia coli O157:H7 str. Sakai 916008 NP_312172.1 CDS ECs4145 NC_002695.1 4164032 4164802 D similar to YRDA_ECOLI gi|1789673 (conserved in Escherichia coli K-12); transferase 4164032..4164802 Escherichia coli O157:H7 str. Sakai 916001 NP_312173.1 CDS ECs4146 NC_002695.1 4164778 4165035 R similar to YRDB_ECOLI gi|1789674 (conserved in Escherichia coli K-12); hypothetical protein complement(4164778..4165035) Escherichia coli O157:H7 str. Sakai 915999 NP_312174.1 CDS aroE NC_002695.1 4165032 4165850 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(4165032..4165850) Escherichia coli O157:H7 str. Sakai 915998 NP_312175.1 CDS ECs4148 NC_002695.1 4165855 4166427 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor complement(4165855..4166427) Escherichia coli O157:H7 str. Sakai 915997 NP_312176.1 CDS ECs4149 NC_002695.1 4166432 4166737 R similar to YRDD_ECOLI gi|1789677; hypothetical protein complement(4166432..4166737) Escherichia coli O157:H7 str. Sakai 915996 NP_312177.1 CDS ECs4150 NC_002695.1 4167003 4167476 R similar to SMG_ECOLI gi|1789679 (conserved in Escherichia coli K-12); hypothetical protein complement(4167003..4167476) Escherichia coli O157:H7 str. Sakai 915995 NP_312178.1 CDS ECs4151 NC_002695.1 4167448 4168572 R similar to SMF_ECOLI Sp|P30852 (conserved in Escherichia coli K-12); DNA protecting protein DprA complement(4167448..4168572) Escherichia coli O157:H7 str. Sakai 915994 NP_312179.1 CDS def NC_002695.1 4168702 4169211 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 4168702..4169211 Escherichia coli O157:H7 str. Sakai 915993 NP_312180.1 CDS fmt NC_002695.1 4169226 4170173 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 4169226..4170173 Escherichia coli O157:H7 str. Sakai 915992 NP_312181.1 CDS ECs4154 NC_002695.1 4170219 4171508 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 4170219..4171508 Escherichia coli O157:H7 str. Sakai 915991 NP_312182.1 CDS trkA NC_002695.1 4171530 4172906 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 4171530..4172906 Escherichia coli O157:H7 str. Sakai 915986 NP_312183.1 CDS mscL NC_002695.1 4173036 4173446 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 4173036..4173446 Escherichia coli O157:H7 str. Sakai 915989 NP_944562.1 CDS ECs5530 NC_002695.1 4173443 4173661 R hypothetical protein complement(4173443..4173661) Escherichia coli O157:H7 str. Sakai 2693746 NP_312184.1 CDS zntR NC_002695.1 4173717 4174142 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(4173717..4174142) Escherichia coli O157:H7 str. Sakai 915990 NP_312185.1 CDS ECs4158 NC_002695.1 4174153 4174521 R similar to YHDN_ECOLI gi|1789688 (conserved in Escherichia coli K-12); hypothetical protein complement(4174153..4174521) Escherichia coli O157:H7 str. Sakai 915988 NP_312186.1 CDS rplQ NC_002695.1 4174628 4175011 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(4174628..4175011) Escherichia coli O157:H7 str. Sakai 915985 NP_312187.1 CDS ECs4160 NC_002695.1 4175052 4176041 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(4175052..4176041) Escherichia coli O157:H7 str. Sakai 915984 NP_312188.1 CDS rpsD NC_002695.1 4176067 4176687 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(4176067..4176687) Escherichia coli O157:H7 str. Sakai 915983 NP_312189.1 CDS ECs4162 NC_002695.1 4176721 4177110 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(4176721..4177110) Escherichia coli O157:H7 str. Sakai 915982 NP_312190.1 CDS rpsM NC_002695.1 4177127 4177483 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(4177127..4177483) Escherichia coli O157:H7 str. Sakai 915981 NP_312191.1 CDS rpmJ NC_002695.1 4177630 4177746 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(4177630..4177746) Escherichia coli O157:H7 str. Sakai 915980 NP_312192.1 CDS secY NC_002695.1 4177778 4179109 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(4177778..4179109) Escherichia coli O157:H7 str. Sakai 915941 NP_312193.1 CDS rplO NC_002695.1 4179117 4179551 R late assembly protein; 50S ribosomal protein L15 complement(4179117..4179551) Escherichia coli O157:H7 str. Sakai 915945 NP_312194.1 CDS rpmD NC_002695.1 4179555 4179734 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(4179555..4179734) Escherichia coli O157:H7 str. Sakai 915946 NP_312195.1 CDS rpsE NC_002695.1 4179738 4180241 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(4179738..4180241) Escherichia coli O157:H7 str. Sakai 915963 NP_312196.1 CDS rplR NC_002695.1 4180256 4180609 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(4180256..4180609) Escherichia coli O157:H7 str. Sakai 915979 NP_312197.1 CDS rplF NC_002695.1 4180619 4181152 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(4180619..4181152) Escherichia coli O157:H7 str. Sakai 915978 NP_312198.1 CDS rpsH NC_002695.1 4181165 4181557 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(4181165..4181557) Escherichia coli O157:H7 str. Sakai 915977 NP_312199.1 CDS rpsN NC_002695.1 4181591 4181896 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(4181591..4181896) Escherichia coli O157:H7 str. Sakai 915976 NP_312200.1 CDS rplE NC_002695.1 4181911 4182450 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(4181911..4182450) Escherichia coli O157:H7 str. Sakai 915975 NP_312201.1 CDS rplX NC_002695.1 4182465 4182779 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(4182465..4182779) Escherichia coli O157:H7 str. Sakai 915974 NP_312202.1 CDS rplN NC_002695.1 4182790 4183161 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(4182790..4183161) Escherichia coli O157:H7 str. Sakai 915973 NP_312203.1 CDS rpsQ NC_002695.1 4183326 4183580 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(4183326..4183580) Escherichia coli O157:H7 str. Sakai 915972 NP_312204.1 CDS rpmC NC_002695.1 4183580 4183771 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(4183580..4183771) Escherichia coli O157:H7 str. Sakai 915971 NP_312205.1 CDS rplP NC_002695.1 4183771 4184181 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(4183771..4184181) Escherichia coli O157:H7 str. Sakai 915970 NP_312206.1 CDS rpsC NC_002695.1 4184194 4184895 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(4184194..4184895) Escherichia coli O157:H7 str. Sakai 915969 NP_312207.1 CDS rplV NC_002695.1 4184913 4185245 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(4184913..4185245) Escherichia coli O157:H7 str. Sakai 915968 NP_312208.1 CDS rpsS NC_002695.1 4185260 4185538 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(4185260..4185538) Escherichia coli O157:H7 str. Sakai 915967 NP_312209.1 CDS rplB NC_002695.1 4185555 4186376 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(4185555..4186376) Escherichia coli O157:H7 str. Sakai 915966 NP_312210.1 CDS rplW NC_002695.1 4186394 4186696 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(4186394..4186696) Escherichia coli O157:H7 str. Sakai 915965 NP_312211.1 CDS rplD NC_002695.1 4186693 4187298 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(4186693..4187298) Escherichia coli O157:H7 str. Sakai 915964 NP_312212.1 CDS rplC NC_002695.1 4187309 4187938 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(4187309..4187938) Escherichia coli O157:H7 str. Sakai 915962 NP_312213.1 CDS rpsJ NC_002695.1 4187971 4188282 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(4187971..4188282) Escherichia coli O157:H7 str. Sakai 915961 NP_312214.1 CDS ECs4187 NC_002695.1 4188427 4188612 D hypothetical protein 4188427..4188612 Escherichia coli O157:H7 str. Sakai 915960 NP_312215.1 CDS ECs4188 NC_002695.1 4188661 4189128 D similar to leader peptidases e.g. HopD (strain ECOR30) [Escherichia coli] gi|7674073|sp|O68932, (LT2) [Salmonella typhimurium] gi|7674072|sp|O68927; HopD 4188661..4189128 Escherichia coli O157:H7 str. Sakai 915959 NP_312216.1 CDS ECs4189 NC_002695.1 4189125 4189601 R iron storage protein; bacterioferritin complement(4189125..4189601) Escherichia coli O157:H7 str. Sakai 915958 NP_944563.1 CDS ECs5531 NC_002695.1 4189674 4189868 R bacterioferritin-associated ferredoxin complement(4189674..4189868) Escherichia coli O157:H7 str. Sakai 2693826 NP_312217.1 CDS tuf NC_002695.1 4190051 4191235 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(4190051..4191235) Escherichia coli O157:H7 str. Sakai 915957 NP_312218.1 CDS ECs4191 NC_002695.1 4191306 4193420 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(4191306..4193420) Escherichia coli O157:H7 str. Sakai 915956 NP_312219.1 CDS ECs4192 NC_002695.1 4193517 4193987 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(4193517..4193987) Escherichia coli O157:H7 str. Sakai 915955 NP_312220.1 CDS rpsL NC_002695.1 4194084 4194458 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(4194084..4194458) Escherichia coli O157:H7 str. Sakai 915954 NP_312221.1 CDS ECs4194 NC_002695.1 4194584 4194871 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(4194584..4194871) Escherichia coli O157:H7 str. Sakai 915953 NP_312222.1 CDS ECs4195 NC_002695.1 4194879 4195238 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(4194879..4195238) Escherichia coli O157:H7 str. Sakai 915952 NP_312223.1 CDS ECs4196 NC_002695.1 4195238 4195624 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(4195238..4195624) Escherichia coli O157:H7 str. Sakai 915951 NP_312224.2 CDS ECs4197 NC_002695.1 4195624 4196346 R similar to YHEO_ECOLI gi|1789744 (conserved in Escherichia coli K-12); hypothetical protein complement(4195624..4196346) Escherichia coli O157:H7 str. Sakai 915950 NP_312225.1 CDS ECs4198 NC_002695.1 4196513 4197325 R rotamase; FKBP-type peptidylprolyl isomerase complement(4196513..4197325) Escherichia coli O157:H7 str. Sakai 915949 NP_312226.1 CDS ECs4199 NC_002695.1 4197546 4197764 D similar to SLYX_ECOLI gi|1789747 (conserved in Escherichia coli K-12); hypothetical protein 4197546..4197764 Escherichia coli O157:H7 str. Sakai 915948 NP_312227.1 CDS ECs4200 NC_002695.1 4197813 4198403 R rotamase; FKBP-type peptidylprolyl isomerase complement(4197813..4198403) Escherichia coli O157:H7 str. Sakai 915947 NP_944564.1 CDS ECs5532 NC_002695.1 4198498 4198698 R hypothetical protein complement(4198498..4198698) Escherichia coli O157:H7 str. Sakai 2693827 NP_312228.1 CDS ECs4201 NC_002695.1 4198735 4200513 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(4198735..4200513) Escherichia coli O157:H7 str. Sakai 915944 NP_312229.1 CDS ECs4202 NC_002695.1 4200513 4201067 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(4200513..4201067) Escherichia coli O157:H7 str. Sakai 915943 NP_312230.1 CDS ECs4203 NC_002695.1 4201195 4203108 D similar to YHES_ECOLI gi|1789751 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4201195..4203108 Escherichia coli O157:H7 str. Sakai 915942 NP_312231.1 CDS ECs4204 NC_002695.1 4203108 4204130 D similar to YHET_ECOLI gi|1789752 (conserved in Escherichia coli K-12); hydrolase 4203108..4204130 Escherichia coli O157:H7 str. Sakai 915940 NP_312232.1 CDS ECs4205 NC_002695.1 4204124 4204342 D similar to YHEU_ECOLI gi|1789753 (conserved in Escherichia coli K-12); hypothetical protein 4204124..4204342 Escherichia coli O157:H7 str. Sakai 915939 NP_312233.1 CDS ECs4206 NC_002695.1 4204396 4205265 D similar to PRKB_ECOLI gi|2367214 (conserved in Escherichia coli K-12); phosphoribulokinase 4204396..4205265 Escherichia coli O157:H7 str. Sakai 915938 NP_312234.1 CDS ECs4207 NC_002695.1 4205320 4205724 R similar to YHFA_ECOLI gi|1789755 (conserved in Escherichia coli K-12); hypothetical protein complement(4205320..4205724) Escherichia coli O157:H7 str. Sakai 915937 NP_312235.1 CDS ECs4208 NC_002695.1 4206026 4206658 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 4206026..4206658 Escherichia coli O157:H7 str. Sakai 915936 NP_312236.1 CDS ECs4209 NC_002695.1 4206709 4208799 D similar to YHFK_ECOLI gi|1789757 (conserved in Escherichia coli K-12); hypothetical protein 4206709..4208799 Escherichia coli O157:H7 str. Sakai 915935 NP_312237.1 CDS argD NC_002695.1 4208866 4210086 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase complement(4208866..4210086) Escherichia coli O157:H7 str. Sakai 915934 NP_312238.1 CDS ECs4211 NC_002695.1 4210172 4210735 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(4210172..4210735) Escherichia coli O157:H7 str. Sakai 915933 NP_312239.1 CDS ECs4212 NC_002695.1 4210767 4211369 R induced in stationary phase; recognized by rpoS; affects cell division; similar to FIC_ECOLI gi|1789761 (conserved in Escherichia coli K-12); cell filamentation protein Fic complement(4210767..4211369) Escherichia coli O157:H7 str. Sakai 915932 NP_312240.1 CDS ECs4213 NC_002695.1 4211359 4211526 R similar to YHFG_ECOLI gi|1789762 (conserved in Escherichia coli K-12); hypothetical protein complement(4211359..4211526) Escherichia coli O157:H7 str. Sakai 915931 NP_312241.1 CDS ECs4214 NC_002695.1 4211631 4212203 R similar to PPIA_ECOLI gi|1789763 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase A complement(4211631..4212203) Escherichia coli O157:H7 str. Sakai 915930 NP_312242.1 CDS ECs4215 NC_002695.1 4212474 4213655 D similar to YHFC_ECOLI gi|1789764 (conserved in Escherichia coli K-12); hypothetical protein 4212474..4213655 Escherichia coli O157:H7 str. Sakai 915929 NP_312243.1 CDS ECs4216 NC_002695.1 4213917 4216460 D similar to NIRB_ECOLI gi|1789765 (conserved in Escherichia coli K-12); nitrite reductase (NAD(P)H) subunit 4213917..4216460 Escherichia coli O157:H7 str. Sakai 915928 NP_312244.1 CDS nirD NC_002695.1 4216457 4216783 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 4216457..4216783 Escherichia coli O157:H7 str. Sakai 915916 NP_312245.2 CDS ECs4218 NC_002695.1 4216909 4217715 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 4216909..4217715 Escherichia coli O157:H7 str. Sakai 915909 NP_312246.1 CDS cysG NC_002695.1 4217734 4219107 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 4217734..4219107 Escherichia coli O157:H7 str. Sakai 915926 NP_312247.1 CDS ECs4220 NC_002695.1 4219362 4219529 D similar to YHFL_ECOLI gi|1789770 (conserved in Escherichia coli K-12); hypothetical protein 4219362..4219529 Escherichia coli O157:H7 str. Sakai 915927 NP_312248.1 CDS frlA NC_002695.1 4219774 4221162 D inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 4219774..4221162 Escherichia coli O157:H7 str. Sakai 915924 NP_312249.1 CDS frlB NC_002695.1 4221162 4222205 D catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 4221162..4222205 Escherichia coli O157:H7 str. Sakai 915923 NP_312250.1 CDS ECs4223 NC_002695.1 4222256 4223083 D YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 4222256..4223083 Escherichia coli O157:H7 str. Sakai 915922 NP_312251.1 CDS ECs4224 NC_002695.1 4223083 4223415 D similar to YHFQ_ECOLI gi|1789775 (conserved in Escherichia coli K-12); hypothetical protein 4223083..4223415 Escherichia coli O157:H7 str. Sakai 915921 NP_312252.3 CDS ECs4225 NC_002695.1 4223902 4224699 D may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 4223902..4224699 Escherichia coli O157:H7 str. Sakai 915920 NP_312253.1 CDS ECs4226 NC_002695.1 4224830 4225834 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(4224830..4225834) Escherichia coli O157:H7 str. Sakai 915919 NP_312254.1 CDS ECs4227 NC_002695.1 4225827 4226585 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(4225827..4226585) Escherichia coli O157:H7 str. Sakai 915918 NP_312255.1 CDS ECs4228 NC_002695.1 4226578 4227255 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(4226578..4227255) Escherichia coli O157:H7 str. Sakai 915917 NP_312256.1 CDS ECs4229 NC_002695.1 4227273 4228109 R similar to DAM_ECOLI gi|1789789 (conserved in Escherichia coli K-12); DNA adenine methylase complement(4227273..4228109) Escherichia coli O157:H7 str. Sakai 915915 NP_312257.1 CDS ECs4230 NC_002695.1 4228216 4229502 R membrane protein ; similar to DAMX_ECOLI gi|1789790 (conserved in Escherichia coli K-12); hypothetical protein complement(4228216..4229502) Escherichia coli O157:H7 str. Sakai 915914 NP_312258.1 CDS aroB NC_002695.1 4229594 4230682 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(4229594..4230682) Escherichia coli O157:H7 str. Sakai 915913 NP_312259.2 CDS aroK NC_002695.1 4230739 4231260 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(4230739..4231260) Escherichia coli O157:H7 str. Sakai 915912 NP_312260.1 CDS hofQ NC_002695.1 4231661 4232899 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(4231661..4232899) Escherichia coli O157:H7 str. Sakai 915911 NP_312261.2 CDS ECs4234 NC_002695.1 4232811 4233215 R similar to YRFA_ECOLI gi|1789794 (conserved in Escherichia coli K-12); hypothetical protein complement(4232811..4233215) Escherichia coli O157:H7 str. Sakai 915910 NP_312262.1 CDS ECs4235 NC_002695.1 4233205 4233645 R similar to YRFB_ECOLI gi|1789795 (conserved in Escherichia coli K-12); hypothetical protein complement(4233205..4233645) Escherichia coli O157:H7 str. Sakai 915908 NP_312263.1 CDS ECs4236 NC_002695.1 4233629 4234168 R similar to YRFC_ECOLI gi|1789796 (conserved in Escherichia coli K-12); hypothetical protein complement(4233629..4234168) Escherichia coli O157:H7 str. Sakai 915898 NP_312264.1 CDS ECs4237 NC_002695.1 4234152 4234946 R similar to YRFD_ECOLI gi|1789797 (conserved in Escherichia coli K-12); hypothetical protein complement(4234152..4234946) Escherichia coli O157:H7 str. Sakai 915902 NP_312265.2 CDS mrcA NC_002695.1 4235066 4237618 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4235066..4237618 Escherichia coli O157:H7 str. Sakai 915905 NP_312266.1 CDS nudE NC_002695.1 4237783 4238343 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(4237783..4238343) Escherichia coli O157:H7 str. Sakai 915907 NP_312267.1 CDS ECs4240 NC_002695.1 4238663 4240798 D similar to YRFF_ECOLI gi|1789801 (conserved in Escherichia coli K-12); dehydrogenase 4238663..4240798 Escherichia coli O157:H7 str. Sakai 915906 NP_312268.2 CDS ECs4241 NC_002695.1 4240863 4241531 D similar to YRFG_ECOLI gi|1789802 (conserved in Escherichia coli K-12); phosphatase 4240863..4241531 Escherichia coli O157:H7 str. Sakai 915904 NP_312269.1 CDS ECs4242 NC_002695.1 4241542 4241943 D similar to HSLR_ECOLI gi|1176866|sp|P45802 (conserved in Escherichia coli K-12); ribosome-associated heat shock protein Hsp15 4241542..4241943 Escherichia coli O157:H7 str. Sakai 915903 NP_312270.3 CDS hslO NC_002695.1 4241968 4242846 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 4241968..4242846 Escherichia coli O157:H7 str. Sakai 915901 NP_312271.1 CDS ECs4244 NC_002695.1 4242909 4244633 R similar to YHGE_ECOLI gi|1789805 (conserved in Escherichia coli K-12); transport complement(4242909..4244633) Escherichia coli O157:H7 str. Sakai 915900 NP_312272.1 CDS ECs4245 NC_002695.1 4245012 4246634 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4245012..4246634 Escherichia coli O157:H7 str. Sakai 915899 NP_312273.1 CDS envZ NC_002695.1 4246710 4248062 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(4246710..4248062) Escherichia coli O157:H7 str. Sakai 915897 NP_312274.1 CDS ompR NC_002695.1 4248059 4248778 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(4248059..4248778) Escherichia coli O157:H7 str. Sakai 915896 NP_312275.2 CDS greB NC_002695.1 4249006 4249482 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4249006..4249482 Escherichia coli O157:H7 str. Sakai 915895 NP_312276.1 CDS ECs4249 NC_002695.1 4249678 4251900 D similar to YHGF_ECOLI gi|1789811 (conserved in Escherichia coli K-12); hypothetical protein 4249678..4251900 Escherichia coli O157:H7 str. Sakai 915894 NP_312277.1 CDS feoA NC_002695.1 4252338 4252565 D similar to FEOA_ECOLI gi|1789812 (conserved in Escherichia coli K-12); ferrous iron transport protein A 4252338..4252565 Escherichia coli O157:H7 str. Sakai 915893 NP_312278.1 CDS feoB NC_002695.1 4252582 4254903 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4252582..4254903 Escherichia coli O157:H7 str. Sakai 915892 NP_312279.1 CDS ECs4252 NC_002695.1 4254903 4255139 D similar to YHGG_ECOLI gi|1789814 (conserved in Escherichia coli K-12); hypothetical protein 4254903..4255139 Escherichia coli O157:H7 str. Sakai 915891 NP_312280.1 CDS ECs4253 NC_002695.1 4255342 4256220 D similar to YHGA_ECOLI gi|1789816 (conserved in Escherichia coli K-12); hypothetical protein 4255342..4256220 Escherichia coli O157:H7 str. Sakai 915890 NP_312281.1 CDS ECs4255 NC_002695.1 4256247 4257017 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(4256247..4257017) Escherichia coli O157:H7 str. Sakai 915889 NP_312282.2 CDS ECs4254 NC_002695.1 4257055 4257738 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4257055..4257738 Escherichia coli O157:H7 str. Sakai 915887 NP_312283.1 CDS ECs4256 NC_002695.1 4257797 4258372 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 4257797..4258372 Escherichia coli O157:H7 str. Sakai 915886 NP_312284.1 CDS ECs4257 NC_002695.1 4258733 4260049 D similar to GNTT_ECOLI gi|1789820 (conserved in Escherichia coli K-12); gluconate permease 4258733..4260049 Escherichia coli O157:H7 str. Sakai 915875 NP_312285.1 CDS malQ NC_002695.1 4260094 4262178 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(4260094..4262178) Escherichia coli O157:H7 str. Sakai 915883 NP_312286.1 CDS ECs4259 NC_002695.1 4262188 4264581 R similar to MALP_ECOLI gi|2367221 (conserved in Escherichia coli K-12); maltodextrin phosphorylase complement(4262188..4264581) Escherichia coli O157:H7 str. Sakai 915885 NP_312287.1 CDS ECs4260 NC_002695.1 4265193 4267898 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 4265193..4267898 Escherichia coli O157:H7 str. Sakai 915884 NP_312288.1 CDS ECs4261 NC_002695.1 4267959 4268243 D similar to hypothetical protein [Xylella fastidiosa] gi|9112262|gb|AAF85593.1|AE003851_24; hypothetical protein 4267959..4268243 Escherichia coli O157:H7 str. Sakai 915882 NP_312289.1 CDS ECs4262 NC_002695.1 4268234 4268719 D similar to hypothetical protein [Xylella fastidiosa] gi|9112263|gb|AAF85594.1|AE003851_25; hypothetical protein 4268234..4268719 Escherichia coli O157:H7 str. Sakai 915881 NP_312290.1 CDS ECs4263 NC_002695.1 4268769 4269800 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(4268769..4269800) Escherichia coli O157:H7 str. Sakai 915880 NP_312291.1 CDS ECs4264 NC_002695.1 4269801 4271027 R similar to RTCB_ECOLI gi|2367224 (conserved in Escherichia coli K-12); hypothetical protein complement(4269801..4271027) Escherichia coli O157:H7 str. Sakai 915879 NP_312292.1 CDS ECs4265 NC_002695.1 4271215 4272813 D similar to RTCR_ECOLI gi|1789828 (conserved in Escherichia coli K-12); 2-component regulator 4271215..4272813 Escherichia coli O157:H7 str. Sakai 915878 NP_312293.1 CDS ECs4266 NC_002695.1 4272795 4273553 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(4272795..4273553) Escherichia coli O157:H7 str. Sakai 915877 NP_312294.1 CDS ECs4267 NC_002695.1 4273570 4274400 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(4273570..4274400) Escherichia coli O157:H7 str. Sakai 915876 NP_312295.1 CDS glpE NC_002695.1 4274445 4274771 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(4274445..4274771) Escherichia coli O157:H7 str. Sakai 915874 NP_312296.1 CDS glpD NC_002695.1 4274961 4276466 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4274961..4276466 Escherichia coli O157:H7 str. Sakai 915873 NP_312297.1 CDS ECs4270 NC_002695.1 4276681 4277280 R hypothetical protein complement(4276681..4277280) Escherichia coli O157:H7 str. Sakai 915872 NP_312298.1 CDS ECs4271 NC_002695.1 4277283 4278275 R similar to binding proteins e.g. phosphate-binding protein PstS homolog [Methanobacterium thermoautotrophicum (strain Delta H)] gi|7442891|pir||A69098; ABC transporter ATP-binding protein complement(4277283..4278275) Escherichia coli O157:H7 str. Sakai 915856 NP_312299.1 CDS ECs4272 NC_002695.1 4278301 4279818 R similar to YZGL_ECOLI gi|1789834, phosphate-binding proteins PstS homolog; hypothetical protein complement(4278301..4279818) Escherichia coli O157:H7 str. Sakai 915865 NP_312300.1 CDS ECs4273 NC_002695.1 4279934 4282381 R similar to GLGP_ECOLI gi|2367228 (conserved in Escherichia coli K-12); glycogen phosphorylase complement(4279934..4282381) Escherichia coli O157:H7 str. Sakai 915866 NP_312301.1 CDS glgA NC_002695.1 4282400 4283833 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(4282400..4283833) Escherichia coli O157:H7 str. Sakai 915868 NP_312302.1 CDS glgC NC_002695.1 4283833 4285128 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(4283833..4285128) Escherichia coli O157:H7 str. Sakai 915871 NP_312303.1 CDS ECs4276 NC_002695.1 4285146 4287119 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein complement(4285146..4287119) Escherichia coli O157:H7 str. Sakai 915870 NP_312304.1 CDS ECs4277 NC_002695.1 4287116 4289302 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(4287116..4289302) Escherichia coli O157:H7 str. Sakai 915869 NP_312305.1 CDS ECs4278 NC_002695.1 4289575 4290678 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(4289575..4290678) Escherichia coli O157:H7 str. Sakai 915867 NP_312306.1 CDS ECs4279 NC_002695.1 4290870 4291463 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 4290870..4291463 Escherichia coli O157:H7 str. Sakai 915864 NP_312307.1 CDS ECs4280 NC_002695.1 4291509 4292711 R similar to DNA processing chain A (Smf protein), e.g. [Neisseria meningitidis] gi|7378929|emb|CAB83472.1|; DNA processing protein DprA complement(4291509..4292711) Escherichia coli O157:H7 str. Sakai 915863 NP_312312.1 CDS ECs4285 NC_002695.1 4294975 4296315 R similar to GNTU_1_ECOLI gi|1789844, GNTU_ECOLI SW: P46858; low affinity gluconate transporter complement(4294975..4296315) Escherichia coli O157:H7 str. Sakai 915858 NP_312313.2 CDS gntK NC_002695.1 4296319 4296846 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase complement(4296319..4296846) Escherichia coli O157:H7 str. Sakai 915857 NP_312314.1 CDS ECs4287 NC_002695.1 4296985 4297980 R similar to GNTR_ECOLI gi|1789846 (conserved in Escherichia coli K-12); regulator of gluconate operon complement(4296985..4297980) Escherichia coli O157:H7 str. Sakai 915855 NP_312315.1 CDS ECs4288 NC_002695.1 4298204 4298899 R similar to YHHW_ECOLI gi|1789847 (conserved in Escherichia coli K-12); hypothetical protein complement(4298204..4298899) Escherichia coli O157:H7 str. Sakai 915854 NP_312316.1 CDS ECs4289 NC_002695.1 4299022 4300059 R similar to YHHX_ECOLI gi|1789848 (conserved in Escherichia coli K-12); dehydrogenase complement(4299022..4300059) Escherichia coli O157:H7 str. Sakai 915853 NP_312317.1 CDS ECs4290 NC_002695.1 4300393 4300881 D YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 4300393..4300881 Escherichia coli O157:H7 str. Sakai 915852 NP_312318.1 CDS ECs4291 NC_002695.1 4301092 4302003 D hypothetical protein 4301092..4302003 Escherichia coli O157:H7 str. Sakai 915851 NP_312319.1 CDS ECs4292 NC_002695.1 4301952 4302368 R hypothetical protein complement(4301952..4302368) Escherichia coli O157:H7 str. Sakai 915850 NP_312320.1 CDS ggt NC_002695.1 4302737 4304482 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(4302737..4304482) Escherichia coli O157:H7 str. Sakai 915849 NP_312321.1 CDS ECs4294 NC_002695.1 4304602 4305042 D similar to YHHA_ECOLI gi|1789857 (conserved in Escherichia coli K-12); hypothetical protein 4304602..4305042 Escherichia coli O157:H7 str. Sakai 915831 NP_312322.1 CDS ugpQ NC_002695.1 4305029 4305772 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase complement(4305029..4305772) Escherichia coli O157:H7 str. Sakai 915833 NP_312323.2 CDS ugpC NC_002695.1 4305769 4306839 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding protein complement(4305769..4306839) Escherichia coli O157:H7 str. Sakai 915835 NP_312324.1 CDS ECs4297 NC_002695.1 4306841 4307686 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(4306841..4307686) Escherichia coli O157:H7 str. Sakai 915845 NP_312325.1 CDS ECs4298 NC_002695.1 4307683 4308570 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(4307683..4308570) Escherichia coli O157:H7 str. Sakai 915848 NP_312326.1 CDS ECs4299 NC_002695.1 4308668 4309984 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(4308668..4309984) Escherichia coli O157:H7 str. Sakai 915847 NP_312327.1 CDS ECs4300 NC_002695.1 4310344 4311090 R hypothetical protein complement(4310344..4311090) Escherichia coli O157:H7 str. Sakai 915846 NP_312328.2 CDS livF NC_002695.1 4311209 4311922 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding protein complement(4311209..4311922) Escherichia coli O157:H7 str. Sakai 915844 NP_312329.1 CDS livG NC_002695.1 4311924 4312691 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding protein complement(4311924..4312691) Escherichia coli O157:H7 str. Sakai 915843 NP_312330.1 CDS livM NC_002695.1 4312688 4313965 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease complement(4312688..4313965) Escherichia coli O157:H7 str. Sakai 915842 NP_312331.1 CDS ECs4304 NC_002695.1 4313962 4314888 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease LivH complement(4313962..4314888) Escherichia coli O157:H7 str. Sakai 915841 NP_312332.1 CDS ECs4305 NC_002695.1 4314936 4316045 R similar to LIVJ_ECOLI gi|1789870 (conserved in Escherichia coli K-12); periplasmic binding protein of high-affinity leucine-specific transport system complement(4314936..4316045) Escherichia coli O157:H7 str. Sakai 915840 NP_312333.1 CDS ECs4306 NC_002695.1 4316469 4316852 D similar to YHHK_ECOLI gi|1789869 (conserved in Escherichia coli K-12); hypothetical protein 4316469..4316852 Escherichia coli O157:H7 str. Sakai 915839 NP_312334.1 CDS ECs4307 NC_002695.1 4316849 4317376 R similar to hypothetical protein ORF79 [Escherichia coli plasmid pB171] gi|6009455|dbj|BAA84914.1; hypothetical protein complement(4316849..4317376) Escherichia coli O157:H7 str. Sakai 915838 NP_312335.1 CDS ECs4308 NC_002695.1 4317383 4317649 R similar to hypothetical protein ORF80 [Escherichia coli plasmid pB171]; hypothetical protein complement(4317383..4317649) Escherichia coli O157:H7 str. Sakai 915837 NP_312336.1 CDS ECs4309 NC_002695.1 4317799 4318959 R similar to LIVJ_ECOLI gi|1789870 (conserved in Escherichia coli K-12); periplasmic binding protein of high-affinity amino acid transport system complement(4317799..4318959) Escherichia coli O157:H7 str. Sakai 915836 NP_312337.1 CDS ECs4310 NC_002695.1 4319173 4320027 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(4319173..4320027) Escherichia coli O157:H7 str. Sakai 915834 NP_312338.1 CDS ftsX NC_002695.1 4320272 4321330 R ABC transporter, membrane protein; cell division protein FtsX complement(4320272..4321330) Escherichia coli O157:H7 str. Sakai 915832 NP_312339.1 CDS ECs4312 NC_002695.1 4321323 4321991 R ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(4321323..4321991) Escherichia coli O157:H7 str. Sakai 915830 NP_312340.1 CDS ECs4313 NC_002695.1 4321994 4323490 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(4321994..4323490) Escherichia coli O157:H7 str. Sakai 915829 NP_312341.1 CDS rsmD NC_002695.1 4323640 4324236 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4323640..4324236 Escherichia coli O157:H7 str. Sakai 915816 NP_312342.1 CDS ECs4315 NC_002695.1 4324226 4324495 D similar to YHHL_ECOLI gi|1789876 (conserved in Escherichia coli K-12); hypothetical protein 4324226..4324495 Escherichia coli O157:H7 str. Sakai 915824 NP_312343.1 CDS ECs4316 NC_002695.1 4324498 4324857 R similar to YHHM_ECOLI gi|1789877 (conserved in Escherichia coli K-12); receptor complement(4324498..4324857) Escherichia coli O157:H7 str. Sakai 915827 NP_312344.1 CDS ECs4317 NC_002695.1 4324998 4325624 D similar to YHHN_ECOLI gi|1789878 (conserved in Escherichia coli K-12); hypothetical protein 4324998..4325624 Escherichia coli O157:H7 str. Sakai 915828 NP_312345.1 CDS zntA NC_002695.1 4325698 4327896 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4325698..4327896 Escherichia coli O157:H7 str. Sakai 915826 NP_312346.1 CDS ECs4319 NC_002695.1 4327998 4328243 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(4327998..4328243) Escherichia coli O157:H7 str. Sakai 915823 NP_312347.1 CDS ECs4320 NC_002695.1 4328464 4329129 D similar to YHHQ_ECOLI gi|1789882 (conserved in Escherichia coli K-12); hypothetical protein 4328464..4329129 Escherichia coli O157:H7 str. Sakai 915822 NP_312348.3 CDS ECs4321 NC_002695.1 4329202 4329759 D similar to B3472_ECOLI gi|1789883 (conserved in Escherichia coli K-12); hypothetical protein 4329202..4329759 Escherichia coli O157:H7 str. Sakai 915821 NP_312349.2 CDS ECs4322 NC_002695.1 4329763 4330980 R similar to YHHS_ECOLI gi|1789884 (conserved in Escherichia coli K-12); major facilitator superfamily transporter complement(4329763..4330980) Escherichia coli O157:H7 str. Sakai 915820 NP_312350.2 CDS ECs4323 NC_002695.1 4331112 4332161 D similar to YHHT_ECOLI gi|1789885 (conserved in Escherichia coli K-12); hypothetical protein 4331112..4332161 Escherichia coli O157:H7 str. Sakai 915819 NP_312351.1 CDS ECs4324 NC_002695.1 4332553 4332930 D lipoprotein 4332553..4332930 Escherichia coli O157:H7 str. Sakai 915818 NP_312352.1 CDS ECs4325 NC_002695.1 4332999 4334060 D similar to O-methyltransferases e.g. acetylserotonin N-methyltransferase (EC 2.1.1.4) - chicken gi|2498445|sp|Q92056|HIOM_CHICK; O-methyltransferase 4332999..4334060 Escherichia coli O157:H7 str. Sakai 916260 NP_312353.1 CDS ECs4326 NC_002695.1 4334239 4334823 D hypothetical protein 4334239..4334823 Escherichia coli O157:H7 str. Sakai 916231 NP_312354.1 CDS ECs4327 NC_002695.1 4334832 4335641 D similar to acyltransferases e.g. [Neisseria meningitidis MC58] gi|7226953|gb|AAF42046.1|; acyltransferase 4334832..4335641 Escherichia coli O157:H7 str. Sakai 916267 NP_312355.1 CDS ECs4328 NC_002695.1 4335616 4335873 D similar to acyl carrier proteins e.g. [Neisseria meningitidis MC58] gi|7226952|gb|AAF42045.1|; acyl carrier protein 4335616..4335873 Escherichia coli O157:H7 str. Sakai 916270 NP_312356.1 CDS ECs4329 NC_002695.1 4335885 4336136 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 4335885..4336136 Escherichia coli O157:H7 str. Sakai 916293 NP_312357.1 CDS ECs4330 NC_002695.1 4336141 4336722 D similar to integral membrane protein [Neisseria meningitidis] gi|7380586|emb|CAB85174.1; hypothetical protein 4336141..4336722 Escherichia coli O157:H7 str. Sakai 915817 NP_312358.1 CDS ECs4331 NC_002695.1 4336719 4338080 D similar to peptide synthase [Xylella fastidiosa] gi|9105980|gb|AAF83848.1|AE003941_2, p-coumaryl-CoA ligase [Rhodobacter sphaeroides] gi|2764724|emb|CAA05380.1; surfactin synthetase 4336719..4338080 Escherichia coli O157:H7 str. Sakai 915815 NP_312359.1 CDS ECs4332 NC_002695.1 4338067 4338420 D similar to (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratases e.g. [Salmonella typhimurium] gi|140182|sp|P21773|FABZ_SALTY; (3R)-hydroxymyristoyl-ACP dehydratase 4338067..4338420 Escherichia coli O157:H7 str. Sakai 915814 NP_312360.1 CDS ECs4333 NC_002695.1 4338411 4340087 D similar to dolichyl-phosphate mannose synthase related protein Pyrococcus abyssi strain Orsay A75176; hypothetical protein 4338411..4340087 Escherichia coli O157:H7 str. Sakai 915808 NP_312361.1 CDS ECs4334 NC_002695.1 4340091 4340513 D similar to hypothetical proteins e.g.[Deinococcus radiodurans] gi|7471367|pir||B75463; hypothetical protein 4340091..4340513 Escherichia coli O157:H7 str. Sakai 916364 NP_312362.1 CDS ECs4335 NC_002695.1 4340510 4341115 D hypothetical protein 4340510..4341115 Escherichia coli O157:H7 str. Sakai 915809 NP_312363.1 CDS ECs4336 NC_002695.1 4341153 4343402 D similar to membrane protein [Xylella fastidiosa] gi|9105671|gb|AAF83587.1|AE003918_9; hypothetical protein 4341153..4343402 Escherichia coli O157:H7 str. Sakai 915813 NP_312364.1 CDS ECs4337 NC_002695.1 4343399 4343983 D lipoprotein 4343399..4343983 Escherichia coli O157:H7 str. Sakai 915812 NP_312365.1 CDS ECs4338 NC_002695.1 4343985 4345154 D FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4343985..4345154 Escherichia coli O157:H7 str. Sakai 915811 NP_312366.1 CDS ECs4339 NC_002695.1 4345151 4345615 D similar tobeta-hydroxydecanoyl-ACP dehydrase [Pseudomonas aeruginosa] gi|2384563|gb|AAC45619.1|, beta-hydroxydecanoyl-ACP dehydrase,; similar to hypothetical protein [Neisseria meningitidis MC58] gi|7226956|gb|AAF42049.1; beta-hydroxydecanoyl-ACP dehydrase 4345151..4345615 Escherichia coli O157:H7 str. Sakai 915810 NP_312367.1 CDS fabG NC_002695.1 4345615 4346346 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4345615..4346346 Escherichia coli O157:H7 str. Sakai 915807 NP_312368.1 CDS ECs4341 NC_002695.1 4346343 4347572 D FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4346343..4347572 Escherichia coli O157:H7 str. Sakai 915806 NP_312369.1 CDS ECs4342 NC_002695.1 4347574 4348161 D similar to YHHU_ECOLI gi|1789886 (conserved in Escherichia coli K-12); holo-ACP synthase 4347574..4348161 Escherichia coli O157:H7 str. Sakai 915791 NP_312370.1 CDS ECs4343 NC_002695.1 4348272 4349846 D similar to NIKA_ECOLI gi|1789887 (conserved in Escherichia coli K-12); periplasmic binding protein for nickel 4348272..4349846 Escherichia coli O157:H7 str. Sakai 915792 NP_312371.1 CDS ECs4344 NC_002695.1 4349846 4350790 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4349846..4350790 Escherichia coli O157:H7 str. Sakai 915803 NP_312372.1 CDS nikC NC_002695.1 4350787 4351620 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4350787..4351620 Escherichia coli O157:H7 str. Sakai 915805 NP_312373.1 CDS nikD NC_002695.1 4351620 4352384 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4351620..4352384 Escherichia coli O157:H7 str. Sakai 915804 NP_312374.1 CDS nikE NC_002695.1 4352381 4353187 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4352381..4353187 Escherichia coli O157:H7 str. Sakai 915802 NP_312375.1 CDS ECs4348 NC_002695.1 4353193 4353594 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4353193..4353594 Escherichia coli O157:H7 str. Sakai 915801 NP_312376.2 CDS ECs4349 NC_002695.1 4353793 4354539 D similar to transcription regulators e.g. [Escherichia coli] gi|129347|sp|P13669|FARR_ECOLI; GntR family transcriptional regulator 4353793..4354539 Escherichia coli O157:H7 str. Sakai 915800 NP_312377.1 CDS ECs4350 NC_002695.1 4354564 4355037 D similar to PTS system enzyme IIA components e.g. [Escherichia coli K-12] gi|2507274|sp|P37187|PTKA_ECOLI, PTS system frucrose-specific enzyme IIBC component; phosphotransferase system enzyme IIA 4354564..4355037 Escherichia coli O157:H7 str. Sakai 915799 NP_312378.1 CDS ECs4351 NC_002695.1 4355034 4355315 D similar to PTS system, galactitol-specific IIB component [Escherichia coli K-12] gi|2507273|sp|P37188|PTKB_ECOLI; phosphotransferase system enzyme IIB 4355034..4355315 Escherichia coli O157:H7 str. Sakai 915798 NP_312379.1 CDS ECs4352 NC_002695.1 4355392 4356750 D similar to PTS system galactitol-specific enzyme IIC e.g. [Bacillus halodurans] gi|4512376|dbj|BAA75340.1; phosphotransferase system enzyme IIC 4355392..4356750 Escherichia coli O157:H7 str. Sakai 915797 NP_312380.1 CDS ECs4353 NC_002695.1 4356743 4358251 D similar to sugar kinases e.g. xylulokinase (EC 2.7.1.17) [Lactobacillus pentosus] gi|139850|sp|P21939|XYLB_LACPE; sugar kinase 4356743..4358251 Escherichia coli O157:H7 str. Sakai 915796 NP_312381.1 CDS ECs4354 NC_002695.1 4358241 4358510 D similar to phosphotransferase system HPr enzymes e.g. [Xylella fastidiosa] gi|9106413|gb|AAF84212.1|AE003971_11; phosphotransferase system HPr enzyme 4358241..4358510 Escherichia coli O157:H7 str. Sakai 915795 NP_312382.1 CDS gatY NC_002695.1 4358542 4359402 D class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 4358542..4359402 Escherichia coli O157:H7 str. Sakai 915793 NP_312383.1 CDS ECs4356 NC_002695.1 4359452 4359811 R similar to HicB-related protein [Xylella fastidiosa] gi|9106728|gb|AAF84477.1|AE003992_13, HicB [Haemophilus influenzae] gi|3603326|gb|AAC35810.1; HicB-like protein complement(4359452..4359811) Escherichia coli O157:H7 str. Sakai 915789 NP_312384.1 CDS ECs4357 NC_002695.1 4359808 4360083 R similar to HicA [Haemophilus influenzae] gi|3603325|gb|AAC35809.1; HicA-like protein complement(4359808..4360083) Escherichia coli O157:H7 str. Sakai 913929 NP_312385.2 CDS ECs4358 NC_002695.1 4360156 4361280 R similar to YHHJ_ECOLI gi|1789897 (conserved in Escherichia coli K-12); transporter complement(4360156..4361280) Escherichia coli O157:H7 str. Sakai 913953 NP_312386.1 CDS ECs4359 NC_002695.1 4361280 4363964 R similar to YHIH_ECOLI gi|2367231 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein complement(4361280..4363964) Escherichia coli O157:H7 str. Sakai 915790 NP_312387.1 CDS ECs4360 NC_002695.1 4364012 4365079 R similar to YHII_ECOLI gi|1789900 (conserved in Escherichia coli K-12); hypothetical protein complement(4364012..4365079) Escherichia coli O157:H7 str. Sakai 915786 NP_312388.1 CDS ECs4361 NC_002695.1 4365445 4367067 R similar to YHIJ_ECOLI gi|1789902 (conserved in Escherichia coli K-12); hypothetical protein complement(4365445..4367067) Escherichia coli O157:H7 str. Sakai 915788 NP_312389.1 CDS ECs4362 NC_002695.1 4367329 4368939 R similar to YHIL_ECOLI gi|2367233, YHIK_ECOLI gi|1789903; hypothetical protein complement(4367329..4368939) Escherichia coli O157:H7 str. Sakai 915787 NP_312390.1 CDS ECs4363 NC_002695.1 4369224 4370375 D similar to YHIM_ECOLI gi|1789905 (conserved in Escherichia coli K-12); hypothetical protein 4369224..4370375 Escherichia coli O157:H7 str. Sakai 915782 NP_312391.1 CDS ECs4364 NC_002695.1 4370693 4371895 R similar to YHIN_ECOLI gi|2367234 (conserved in Escherichia coli K-12); hypothetical protein complement(4370693..4371895) Escherichia coli O157:H7 str. Sakai 914038 NP_312392.1 CDS ECs4365 NC_002695.1 4372127 4373626 D similar to PITB_ECOLI gi|1789360 (conserved in Escherichia coli K-12); low-affinity phosphate transport protein 4372127..4373626 Escherichia coli O157:H7 str. Sakai 913986 NP_312393.1 CDS ECs4366 NC_002695.1 4373697 4374032 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(4373697..4374032) Escherichia coli O157:H7 str. Sakai 915774 NP_312394.1 CDS ECs4367 NC_002695.1 4374423 4374857 D similar to USPA_ECOLI gi|1789909 (conserved in Escherichia coli K-12); hypothetical protein 4374423..4374857 Escherichia coli O157:H7 str. Sakai 915784 NP_312395.1 CDS ECs4368 NC_002695.1 4375174 4376643 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4375174..4376643 Escherichia coli O157:H7 str. Sakai 915768 NP_312396.1 CDS ECs4369 NC_002695.1 4376692 4377444 R predicted SAM-dependent methyltransferase; methyltransferase complement(4376692..4377444) Escherichia coli O157:H7 str. Sakai 915773 NP_312397.1 CDS ECs4370 NC_002695.1 4377452 4379494 R similar to PRLC_ECOLI gi|1789913 (conserved in Escherichia coli K-12); oligopeptidase A complement(4377452..4379494) Escherichia coli O157:H7 str. Sakai 914095 NP_312398.1 CDS ECs4371 NC_002695.1 4379697 4380539 D similar to YHIR_ECOLI gi|1789914 (conserved in Escherichia coli K-12); hypothetical protein 4379697..4380539 Escherichia coli O157:H7 str. Sakai 915775 NP_312399.1 CDS ECs4372 NC_002695.1 4380611 4381963 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4380611..4381963 Escherichia coli O157:H7 str. Sakai 915781 NP_312400.1 CDS ECs4373 NC_002695.1 4382844 4383197 D regulates the expression of of the arsRBC involved in resistance to arsenic; ArsR family transcriptional regulator 4382844..4383197 Escherichia coli O157:H7 str. Sakai 915778 NP_312401.1 CDS ECs4374 NC_002695.1 4383251 4384540 D similar to ARSF_ECOLI gi|1789917 (conserved in Escherichia coli K-12); arsenical pump membrane protein 4383251..4384540 Escherichia coli O157:H7 str. Sakai 915771 NP_312402.1 CDS ECs4375 NC_002695.1 4384553 4384978 D similar to ARSC_ECOLI gi|1789918 (conserved in Escherichia coli K-12); arsenate reductase 4384553..4384978 Escherichia coli O157:H7 str. Sakai 915766 NP_312403.1 CDS ECs4376 NC_002695.1 4385605 4386720 D similar to YHIS_ECOLI gi|1789920 (conserved in Escherichia coli K-12); hypothetical protein 4385605..4386720 Escherichia coli O157:H7 str. Sakai 915740 NP_312404.2 CDS ECs4377 NC_002695.1 4387074 4387640 D outer membrane protein; similar to SLP_ECOLI gi|1789922 (conserved in Escherichia coli K-12); hypothetical protein 4387074..4387640 Escherichia coli O157:H7 str. Sakai 915741 NP_312405.1 CDS ECs4378 NC_002695.1 4387796 4388326 D similar to YHIF_ECOLI gi|1789923 (conserved in Escherichia coli K-12); hypothetical protein 4387796..4388326 Escherichia coli O157:H7 str. Sakai 915765 NP_312406.1 CDS ECs4379 NC_002695.1 4388387 4389415 R hypothetical protein complement(4388387..4389415) Escherichia coli O157:H7 str. Sakai 915764 NP_312407.1 CDS ECs4380 NC_002695.1 4389464 4391446 R similar to ChuA [Escherichia coli O157:H7 EDL933] gi|1763009|gb|AAC44857.1|; heme utilization/transport protein complement(4389464..4391446) Escherichia coli O157:H7 str. Sakai 915763 NP_312408.1 CDS ECs4381 NC_002695.1 4391722 4391928 R hypothetical protein complement(4391722..4391928) Escherichia coli O157:H7 str. Sakai 915762 NP_312409.1 CDS ECs4382 NC_002695.1 4392129 4393043 D similar to hypothetical protein ShuT [Shigella dysenteriae haem transport locus] gi|2967538|gb|AAC27815.1, hemin-binding proteins e.g. [Yersinia pestis] gi|6226635|; hemin binding protein 4392129..4393043 Escherichia coli O157:H7 str. Sakai 915761 NP_312410.1 CDS ECs4383 NC_002695.1 4393063 4394400 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4393063..4394400 Escherichia coli O157:H7 str. Sakai 915760 NP_312411.1 CDS ECs4384 NC_002695.1 4394413 4394907 D similar to hypothetical protein ShuX [Shigella dysenteriae haem transport locus] gi|2967537|gb|AAC27814.1|, hypothetical protein X [Yersinia pestis] gi|7467368|pir||T12066; ShuX-like protein 4394413..4394907 Escherichia coli O157:H7 str. Sakai 915759 NP_312412.1 CDS ECs4385 NC_002695.1 4394907 4395530 D similar to hypothetical protein ShuY [Shigella dysenteriae haem transport locus] gi|2967536|gb|AAC27813.1|, hypothetical protein Y [Yersinia pestis] gi|7467369|pir||T12067; ShuY-like protein 4394907..4395530 Escherichia coli O157:H7 str. Sakai 915758 NP_312413.1 CDS ECs4386 NC_002695.1 4395615 4396571 D similar to hypothetical protein ShuU [Shigella dysenteriae haem transport locus] gi|2967535|gb|AAC27812.1|, hemin permeases e.g. HmuU [Yersinia pestis] gi|6226636|sp|Q56992|HMUU_YER; hemin permease 4395615..4396571 Escherichia coli O157:H7 str. Sakai 915757 NP_312414.1 CDS hmuV NC_002695.1 4396568 4397338 D with HmuTU is involved in the transport of hemin; hemin importer ATP-binding protein 4396568..4397338 Escherichia coli O157:H7 str. Sakai 915756 NP_312415.1 CDS ECs4388 NC_002695.1 4397390 4398037 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase complement(4397390..4398037) Escherichia coli O157:H7 str. Sakai 915755 NP_312416.1 CDS hdeB NC_002695.1 4398101 4398439 R similar to HDEB_ECOLI gi|1789925 (conserved in Escherichia coli K-12); acid-resistance protein complement(4398101..4398439) Escherichia coli O157:H7 str. Sakai 915754 NP_312417.1 CDS ECs4390 NC_002695.1 4398543 4398875 R inactive form; acid-resistance protein complement(4398543..4398875) Escherichia coli O157:H7 str. Sakai 915753 NP_312418.1 CDS ECs4391 NC_002695.1 4399130 4399702 D similar to HDED_ECOLI gi|1789927 (conserved in Escherichia coli K-12); acid-resistance membrane protein 4399130..4399702 Escherichia coli O157:H7 str. Sakai 915752 NP_312419.1 CDS ECs4392 NC_002695.1 4400501 4401028 D similar to YHIE_ECOLI gi|1789928 (conserved in Escherichia coli K-12); hypothetical protein 4400501..4401028 Escherichia coli O157:H7 str. Sakai 915751 NP_944565.1 CDS ECs5533 NC_002695.1 4401029 4401307 R hypothetical protein complement(4401029..4401307) Escherichia coli O157:H7 str. Sakai 2693781 NP_312420.1 CDS ECs4393 NC_002695.1 4401367 4402524 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4401367..4402524 Escherichia coli O157:H7 str. Sakai 915750 NP_312421.1 CDS ECs4394 NC_002695.1 4402549 4405662 D similar to YHIV_ECOLI gi|1789930 (conserved in Escherichia coli K-12); transport system permease 4402549..4405662 Escherichia coli O157:H7 str. Sakai 915749 NP_312422.1 CDS ECs4395 NC_002695.1 4406025 4406753 R similar to YHIW_ECOLI gi|1789932 (conserved in Escherichia coli K-12); AraC family transcriptional regulator complement(4406025..4406753) Escherichia coli O157:H7 str. Sakai 915748 NP_312423.1 CDS ECs4396 NC_002695.1 4407121 4407945 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(4407121..4407945) Escherichia coli O157:H7 str. Sakai 915747 NP_312424.1 CDS ECs4397 NC_002695.1 4408316 4409716 R similar to GADB_ECOLI gi|1787769 (conserved in Escherichia coli K-12); glutamate decarboxylase complement(4408316..4409716) Escherichia coli O157:H7 str. Sakai 915746 NP_312425.1 CDS ECs4398 NC_002695.1 4409927 4411324 R similar to YHJA_ECOLI gi|1789935 (conserved in Escherichia coli K-12); cytochrome C peroxidase complement(4409927..4411324) Escherichia coli O157:H7 str. Sakai 915744 NP_312426.1 CDS treF NC_002695.1 4411729 4413378 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4411729..4413378 Escherichia coli O157:H7 str. Sakai 915743 NP_312427.1 CDS ECs4400 NC_002695.1 4413429 4414031 R similar to YHJB_ECOLI gi|1789937 (conserved in Escherichia coli K-12); regulator complement(4413429..4414031) Escherichia coli O157:H7 str. Sakai 915742 NP_312428.1 CDS ECs4401 NC_002695.1 4414479 4415450 D similar to YHJC_ECOLI gi|1789938 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 4414479..4415450 Escherichia coli O157:H7 str. Sakai 915735 NP_312429.1 CDS ECs4402 NC_002695.1 4415499 4416512 D similar to YHJD_ECOLI gi|1789939 (conserved in Escherichia coli K-12); hypothetical protein 4415499..4416512 Escherichia coli O157:H7 str. Sakai 915736 NP_312430.1 CDS ECs4403 NC_002695.1 4416924 4418246 D similar to YHJE_ECOLI gi|1789941 (conserved in Escherichia coli K-12); transporter 4416924..4418246 Escherichia coli O157:H7 str. Sakai 915737 NP_312431.1 CDS ECs4404 NC_002695.1 4418428 4420503 R similar to YHJG_ECOLI gi|2367236 (conserved in Escherichia coli K-12); hypothetical protein complement(4418428..4420503) Escherichia coli O157:H7 str. Sakai 915738 NP_312432.1 CDS ECs4405 NC_002695.1 4420558 4421328 R in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein complement(4420558..4421328) Escherichia coli O157:H7 str. Sakai 915731 NP_312433.1 CDS ECs4406 NC_002695.1 4421338 4422486 D similar to KDGK_ECOLI gi|1789945 (conserved in Escherichia coli K-12); 2-dehydro-3-deoxygluconokinase 4421338..4422486 Escherichia coli O157:H7 str. Sakai 915730 NP_312434.1 CDS ECs4407 NC_002695.1 4422582 4424078 R similar to YHJJ_ECOLI gi|1789946 (conserved in Escherichia coli K-12); hypothetical protein complement(4422582..4424078) Escherichia coli O157:H7 str. Sakai 915732 NP_312435.1 CDS ECs4408 NC_002695.1 4424299 4425585 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(4424299..4425585) Escherichia coli O157:H7 str. Sakai 915733 NP_312436.1 CDS ECs4409 NC_002695.1 4425768 4427723 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase complement(4425768..4427723) Escherichia coli O157:H7 str. Sakai 915734 NP_312437.1 CDS ECs4410 NC_002695.1 4427838 4430846 R similar to YHJL_ECOLI gi|2367239 (conserved in Escherichia coli K-12); oxidoreductase subunit complement(4427838..4430846) Escherichia coli O157:H7 str. Sakai 915729 NP_312438.1 CDS ECs4411 NC_002695.1 4431283 4432389 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(4431283..4432389) Escherichia coli O157:H7 str. Sakai 915724 NP_312439.1 CDS ECs4412 NC_002695.1 4432396 4434753 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(4432396..4434753) Escherichia coli O157:H7 str. Sakai 915722 NP_312440.2 CDS bcsA NC_002695.1 4434764 4437382 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(4434764..4437382) Escherichia coli O157:H7 str. Sakai 915726 NP_312441.1 CDS ECs4414 NC_002695.1 4437379 4437915 R similar to YHJQ_ECOLI gi|1789955; hypothetical protein complement(4437379..4437915) Escherichia coli O157:H7 str. Sakai 915727 NP_312442.1 CDS ECs4415 NC_002695.1 4438143 4438331 R similar to YHJR_ECOLI gi|1789956 (conserved in Escherichia coli K-12); hypothetical protein complement(4438143..4438331) Escherichia coli O157:H7 str. Sakai 915723 NP_312443.1 CDS ECs4416 NC_002695.1 4438604 4440175 D similar to YHJS_ECOLI gi|1789958 (conserved in Escherichia coli K-12); protease 4438604..4440175 Escherichia coli O157:H7 str. Sakai 915725 NP_312444.1 CDS ECs4417 NC_002695.1 4440175 4440363 D similar to YHJT_ECOLI gi|1789959 (conserved in Escherichia coli K-12); hypothetical protein 4440175..4440363 Escherichia coli O157:H7 str. Sakai 915718 NP_312445.1 CDS ECs4418 NC_002695.1 4440360 4442039 D similar to YHJU_ECOLI gi|1789960 (conserved in Escherichia coli K-12); hypothetical protein 4440360..4442039 Escherichia coli O157:H7 str. Sakai 915719 NP_312446.1 CDS ECs4419 NC_002695.1 4442709 4443980 D similar to YHJV_ECOLI gi|1789961 (conserved in Escherichia coli K-12); transporter protein 4442709..4443980 Escherichia coli O157:H7 str. Sakai 915720 NP_312447.1 CDS dppF NC_002695.1 4444010 4445014 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; peptide ABC transporter ATP-binding protein complement(4444010..4445014) Escherichia coli O157:H7 str. Sakai 915721 NP_312448.1 CDS dppD NC_002695.1 4445011 4445994 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; peptide ABC transporter ATP-binding protein complement(4445011..4445994) Escherichia coli O157:H7 str. Sakai 915714 NP_312449.1 CDS ECs4422 NC_002695.1 4446005 4446907 R similar to DPPC_ECOLI gi|1789964 (conserved in Escherichia coli K-12); peptide ABC transporter complement(4446005..4446907) Escherichia coli O157:H7 str. Sakai 915715 NP_312450.1 CDS ECs4423 NC_002695.1 4446917 4447936 R transports peptides consisting of two or three amino acids; peptide ABC transporter permease complement(4446917..4447936) Escherichia coli O157:H7 str. Sakai 915716 NP_312451.1 CDS ECs4424 NC_002695.1 4448087 4449694 R similar to DPPA_ECOLI gi|1789966 (conserved in Escherichia coli K-12); peptide ABC transporter complement(4448087..4449694) Escherichia coli O157:H7 str. Sakai 915710 NP_312452.2 CDS ECs4425 NC_002695.1 4450607 4452298 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(4450607..4452298) Escherichia coli O157:H7 str. Sakai 915712 NP_312453.1 CDS ECs4426 NC_002695.1 4452553 4453083 R similar to fimbrial proteins e.g. long polar fimbrial minor protein precursor [Salmonella typhimurium] gi|1170819|sp|P43664|LPFE_SALTY; fimbrial protein complement(4452553..4453083) Escherichia coli O157:H7 str. Sakai 915704 NP_312454.1 CDS ECs4427 NC_002695.1 4453088 4454143 R similar to fimbrial proteins e.g. long polar fimbrial protein LpfD [Salmonella typhimurium] gi|1170818|sp|P43663|LPFD_SALTY; fimbrial protein complement(4453088..4454143) Escherichia coli O157:H7 str. Sakai 915705 NP_312457.2 CDS ECs4430 NC_002695.1 4456760 4457458 R probable fimbrial chaperone protein, similar to chaperones e.g. LpfB [Salmonella typhimurium] gi|1170816|sp|P43661|LPFB_SALTY; fimbrial chaperone protein complement(4456760..4457458) Escherichia coli O157:H7 str. Sakai 915707 NP_312458.1 CDS ECs4431 NC_002695.1 4457511 4458047 R similar to long polar fimbria protein A precursor, LpfA, of S. typhimurium, gi|1170815|sp|P43660|LPFA_SALTY; fimbrial major protein complement(4457511..4458047) Escherichia coli O157:H7 str. Sakai 915703 NP_312459.1 CDS ECs4432 NC_002695.1 4458379 4459581 R similar to YHJX_ECOLI gi|1789969 (conserved in Escherichia coli K-12); resistance protein complement(4458379..4459581) Escherichia coli O157:H7 str. Sakai 914251 NP_312460.2 CDS ECs4433 NC_002695.1 4459810 4460508 R similar to YHJY_ECOLI gi|1789970 (conserved in Escherichia coli K-12); lipase complement(4459810..4460508) Escherichia coli O157:H7 str. Sakai 915700 NP_312461.1 CDS ECs4434 NC_002695.1 4460666 4461229 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4460666..4461229 Escherichia coli O157:H7 str. Sakai 915701 NP_312462.1 CDS ECs4435 NC_002695.1 4461226 4461666 D similar to YIAC_ECOLI gi|1789972 (conserved in Escherichia coli K-12); hypothetical protein 4461226..4461666 Escherichia coli O157:H7 str. Sakai 915702 NP_312463.1 CDS ECs4436 NC_002695.1 4461635 4463854 R similar to BISC_ECOLI gi|1789973 (conserved in Escherichia coli K-12); biotin sulfoxide reductase complement(4461635..4463854) Escherichia coli O157:H7 str. Sakai 915696 NP_312464.1 CDS ECs4437 NC_002695.1 4464121 4464780 D similar to YIAD_ECOLI gi|1789974 (conserved in Escherichia coli K-12); outer membrane lipoprotein 4464121..4464780 Escherichia coli O157:H7 str. Sakai 915683 NP_312465.2 CDS ECs4438 NC_002695.1 4464884 4465858 D Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 4464884..4465858 Escherichia coli O157:H7 str. Sakai 915671 NP_312466.1 CDS ECs4439 NC_002695.1 4465908 4466738 R similar to YIAF_ECOLI gi|1789976 (conserved in Escherichia coli K-12); hypothetical protein complement(4465908..4466738) Escherichia coli O157:H7 str. Sakai 915662 NP_312467.1 CDS ECs4440 NC_002695.1 4467052 4467342 D similar to YIAG_ECOLI gi|1789978 (conserved in Escherichia coli K-12); transcriptional regulator 4467052..4467342 Escherichia coli O157:H7 str. Sakai 915652 NP_312468.1 CDS ECs4441 NC_002695.1 4467623 4467835 D similar to CSPA_ECOLI gi|1789979 (conserved in Escherichia coli K-12); major cold shock protein 4467623..4467835 Escherichia coli O157:H7 str. Sakai 915643 NP_312469.1 CDS glyS NC_002695.1 4468498 4470567 R glycine--tRNA ligase subunit beta; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(4468498..4470567) Escherichia coli O157:H7 str. Sakai 915631 NP_312470.1 CDS glyQ NC_002695.1 4470577 4471488 R glycine--tRNA ligase subunit alpha; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(4470577..4471488) Escherichia coli O157:H7 str. Sakai 915622 NP_944567.1 CDS ECs5536 NC_002695.1 4471583 4471882 R hypothetical protein complement(4471583..4471882) Escherichia coli O157:H7 str. Sakai 2693783 NP_312471.1 CDS ECs4444 NC_002695.1 4472057 4473052 D similar to YIAH_ECOLI gi|1789984 (conserved in Escherichia coli K-12); hypothetical protein 4472057..4473052 Escherichia coli O157:H7 str. Sakai 915620 NP_312472.2 CDS ECs4445 NC_002695.1 4473094 4473531 R similar to YIAA_ECOLI gi|1789985 (conserved in Escherichia coli K-12); hypothetical protein complement(4473094..4473531) Escherichia coli O157:H7 str. Sakai 915619 NP_312473.1 CDS ECs4446 NC_002695.1 4473577 4473930 R similar to YIAB_ECOLI gi|1789986 (conserved in Escherichia coli K-12); hypothetical protein complement(4473577..4473930) Escherichia coli O157:H7 str. Sakai 915617 NP_312474.1 CDS ECs4447 NC_002695.1 4474087 4475541 R similar to XYLB_ECOLI gi|1789987 (conserved in Escherichia coli K-12); xylulokinase complement(4474087..4475541) Escherichia coli O157:H7 str. Sakai 915616 NP_312475.1 CDS ECs4448 NC_002695.1 4475613 4476935 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(4475613..4476935) Escherichia coli O157:H7 str. Sakai 915615 NP_312476.1 CDS xylF NC_002695.1 4477301 4478293 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4477301..4478293 Escherichia coli O157:H7 str. Sakai 915614 NP_312477.1 CDS ECs4450 NC_002695.1 4478371 4479912 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding protein 4478371..4479912 Escherichia coli O157:H7 str. Sakai 915612 NP_312478.1 CDS ECs4451 NC_002695.1 4479890 4481071 D similar to XYLH_ECOLI gi|1789992 (conserved in Escherichia coli K-12); membrane component of xylose transport system 4479890..4481071 Escherichia coli O157:H7 str. Sakai 915611 NP_312479.1 CDS ECs4452 NC_002695.1 4481149 4482327 D similar to XYLR_ECOLI gi|1789993 (conserved in Escherichia coli K-12); regulator of xyl operon 4481149..4482327 Escherichia coli O157:H7 str. Sakai 915610 NP_312480.1 CDS ECs4453 NC_002695.1 4482435 4483259 R similar to BAX_ECOLI gi|1789994 (conserved in Escherichia coli K-12); hypothetical protein complement(4482435..4483259) Escherichia coli O157:H7 str. Sakai 915609 NP_312481.1 CDS malS NC_002695.1 4483579 4485609 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4483579..4485609 Escherichia coli O157:H7 str. Sakai 915608 NP_312482.1 CDS avtA NC_002695.1 4485787 4487040 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4485787..4487040 Escherichia coli O157:H7 str. Sakai 915606 NP_312483.1 CDS ECs4456 NC_002695.1 4487192 4487665 R similar to YIAI_ECOLI YIAI_ECOLI gi|2367245 (conserved in Escherichia coli K-12); hypothetical protein complement(4487192..4487665) Escherichia coli O157:H7 str. Sakai 915605 NP_312484.1 CDS ECs4457 NC_002695.1 4487909 4488724 R similar to hypothetical transcriptional regulator YisR [Bacillus subtilis] gi|3123306|sp|P40331; transcriptional regulator complement(4487909..4488724) Escherichia coli O157:H7 str. Sakai 915603 NP_312485.1 CDS ECs4458 NC_002695.1 4488950 4490350 D similar to hypothetical proteins [Salmonella typhimurium] gi|7442781|pir||C65167, transport proteins ( symporters) e.g. YicJ [Escherichia coli (K-12)] gi|2851421|sp|P31435; permease 4488950..4490350 Escherichia coli O157:H7 str. Sakai 915602 NP_312486.1 CDS ECs4459 NC_002695.1 4490361 4492331 D similar to hypothetical protein [Thermotoga maritima] gi|7452109|pir||F72395; hypothetical protein 4490361..4492331 Escherichia coli O157:H7 str. Sakai 915600 NP_312487.1 CDS ECs4460 NC_002695.1 4492461 4493201 R similar to YIAT_ECOLI gi|1790010 (conserved in Escherichia coli K-12); outer membrane protein complement(4492461..4493201) Escherichia coli O157:H7 str. Sakai 915598 NP_312488.1 CDS ECs4461 NC_002695.1 4493325 4494299 D similar to YIAU_ECOLI gi|1790011 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 4493325..4494299 Escherichia coli O157:H7 str. Sakai 916039 NP_312489.1 CDS ECs4462 NC_002695.1 4494296 4495432 R similar to YIAV_ECOLI gi|1790012 (conserved in Escherichia coli K-12); hypothetical protein complement(4494296..4495432) Escherichia coli O157:H7 str. Sakai 916069 NP_312490.1 CDS ECs4463 NC_002695.1 4495438 4495761 R similar to YIAW_ECOLI gi|1790013 (conserved in Escherichia coli K-12); hypothetical protein complement(4495438..4495761) Escherichia coli O157:H7 str. Sakai 916071 NP_312491.2 CDS ECs4464 NC_002695.1 4496306 4497844 R similar to ALDB_ECOLI gi|1790014 (conserved in Escherichia coli K-12); aldehyde dehydrogenase complement(4496306..4497844) Escherichia coli O157:H7 str. Sakai 915596 NP_312492.1 CDS ECs4465 NC_002695.1 4497952 4499247 R similar to hypothetical protein [Neisseria meningitidis MC58] gi|7227012|gb|AAF42100.1; hypothetical protein complement(4497952..4499247) Escherichia coli O157:H7 str. Sakai 915595 NP_312493.1 CDS ECs4466 NC_002695.1 4499377 4500528 R similar to YIAY_ECOLI gi|1790015 (conserved in Escherichia coli K-12); alcohol dehydrogenase complement(4499377..4500528) Escherichia coli O157:H7 str. Sakai 915594 NP_312494.1 CDS ECs4467 NC_002695.1 4500717 4502561 R similar to SELB_ECOLI gi|2367247 (conserved in Escherichia coli K-12); selenocysteinyl-tRNA-specific translation factor complement(4500717..4502561) Escherichia coli O157:H7 str. Sakai 915593 NP_312495.1 CDS ECs4468 NC_002695.1 4502558 4503949 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(4502558..4503949) Escherichia coli O157:H7 str. Sakai 915592 NP_312496.1 CDS ECs4469 NC_002695.1 4504047 4504655 R similar to YIBF_ECOLI gi|1790018 (conserved in Escherichia coli K-12); glutathione S-transferase complement(4504047..4504655) Escherichia coli O157:H7 str. Sakai 915591 NP_312497.1 CDS ECs4470 NC_002695.1 4504884 4509113 D similar to Rhs core RHSA_ECOLI gi|1790020 (conserved in Escherichia coli K-12); rhsA core protein with extension 4504884..4509113 Escherichia coli O157:H7 str. Sakai 915590 NP_312498.1 CDS ECs4471 NC_002695.1 4509125 4509586 D similar to YIBG_ECOLI gi|1790023 (conserved in Escherichia coli K-12); hypothetical protein 4509125..4509586 Escherichia coli O157:H7 str. Sakai 915589 NP_312499.1 CDS ECs4472 NC_002695.1 4510293 4510628 D hypothetical protein 4510293..4510628 Escherichia coli O157:H7 str. Sakai 915588 NP_312500.1 CDS ECs4473 NC_002695.1 4511190 4512326 R similar to YIBH_ECOLI gi|1790024; hypothetical protein complement(4511190..4512326) Escherichia coli O157:H7 str. Sakai 915586 NP_312501.1 CDS ECs4474 NC_002695.1 4512329 4512691 R similar to YIBI_ECOLI gi|1790025 (conserved in Escherichia coli K-12); hypothetical protein complement(4512329..4512691) Escherichia coli O157:H7 str. Sakai 915584 NP_312502.1 CDS ECs4475 NC_002695.1 4513228 4515141 D similar to MTLA_ECOLI gi|1790027 (conserved in Escherichia coli K-12); mannitol-specific PTS system enzyme IIABC components 4513228..4515141 Escherichia coli O157:H7 str. Sakai 915583 NP_312503.1 CDS ECs4476 NC_002695.1 4515236 4516384 D similar to MTLD_ECOLI gi|1790028 (conserved in Escherichia coli K-12); mannitol-1-phosphate 5-dehydrogenase 4515236..4516384 Escherichia coli O157:H7 str. Sakai 915582 NP_312504.1 CDS mtlR NC_002695.1 4516384 4516971 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 4516384..4516971 Escherichia coli O157:H7 str. Sakai 915581 NP_312505.1 CDS ECs4478 NC_002695.1 4517477 4517839 D similar to YIBL_ECOLI gi|1790030 (conserved in Escherichia coli K-12); hypothetical protein 4517477..4517839 Escherichia coli O157:H7 str. Sakai 915580 NP_312506.1 CDS ECs4479 NC_002695.1 4518484 4519065 D hypothetical protein 4518484..4519065 Escherichia coli O157:H7 str. Sakai 915579 NP_312507.1 CDS ECs4480 NC_002695.1 4519109 4523875 D similar to surface proteins, e.g.[Xylella fastidiosa] gi|9106565|gb|AAF84338.1|AE003982_11; hypothetical protein 4519109..4523875 Escherichia coli O157:H7 str. Sakai 915578 NP_312508.1 CDS ECs4481 NC_002695.1 4524243 4525898 D similar to LLDP_ECOLI gi|1790031 (conserved in Escherichia coli K-12); L-lactate permease 4524243..4525898 Escherichia coli O157:H7 str. Sakai 915577 NP_312509.1 CDS ECs4482 NC_002695.1 4525898 4526674 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4525898..4526674 Escherichia coli O157:H7 str. Sakai 915576 NP_312510.1 CDS lldD NC_002695.1 4526671 4527861 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4526671..4527861 Escherichia coli O157:H7 str. Sakai 915575 NP_312511.1 CDS ECs4484 NC_002695.1 4528047 4528520 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4528047..4528520 Escherichia coli O157:H7 str. Sakai 915574 NP_312512.1 CDS cysE NC_002695.1 4528573 4529394 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(4528573..4529394) Escherichia coli O157:H7 str. Sakai 915573 NP_312513.1 CDS gpsA NC_002695.1 4529474 4530493 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(4529474..4530493) Escherichia coli O157:H7 str. Sakai 915571 NP_312514.1 CDS ECs4487 NC_002695.1 4530493 4530960 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(4530493..4530960) Escherichia coli O157:H7 str. Sakai 915570 NP_312515.1 CDS ECs4488 NC_002695.1 4531023 4531274 R similar to GRXC_ECOLI gi|1790039 (conserved in Escherichia coli K-12); glutaredoxin 3 complement(4531023..4531274) Escherichia coli O157:H7 str. Sakai 915569 NP_312516.1 CDS ECs4489 NC_002695.1 4531416 4531847 R similar to YIBN_ECOLI gi|1790040 (conserved in Escherichia coli K-12); hypothetical protein complement(4531416..4531847) Escherichia coli O157:H7 str. Sakai 915568 NP_312517.1 CDS ECs4490 NC_002695.1 4532092 4533636 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4532092..4533636 Escherichia coli O157:H7 str. Sakai 915565 NP_312518.1 CDS ECs4491 NC_002695.1 4533646 4534929 D similar to YIBP_ECOLI gi|1790042 (conserved in Escherichia coli K-12); hypothetical protein 4533646..4534929 Escherichia coli O157:H7 str. Sakai 915564 NP_312519.2 CDS ECs4492 NC_002695.1 4534933 4535892 D similar to YIBQ_ECOLI gi|1790043 (conserved in Escherichia coli K-12); hypothetical protein 4534933..4535892 Escherichia coli O157:H7 str. Sakai 915562 NP_312520.1 CDS ECs4493 NC_002695.1 4535898 4536914 R similar to YIBD_ECOLI gi|1790044 (conserved in Escherichia coli K-12); glycosyl transferase family protein complement(4535898..4536914) Escherichia coli O157:H7 str. Sakai 915561 NP_312521.1 CDS tdh NC_002695.1 4537153 4538178 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(4537153..4538178) Escherichia coli O157:H7 str. Sakai 915560 NP_312522.1 CDS ECs4495 NC_002695.1 4538188 4539384 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase complement(4538188..4539384) Escherichia coli O157:H7 str. Sakai 915559 NP_312523.1 CDS ECs4496 NC_002695.1 4539659 4540531 R similar to HTRL_ECOLI gi|1790048 (conserved in Escherichia coli K-12); hypothetical protein complement(4539659..4540531) Escherichia coli O157:H7 str. Sakai 915558 NP_312524.1 CDS rfaD NC_002695.1 4540820 4541752 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4540820..4541752 Escherichia coli O157:H7 str. Sakai 915557 NP_312525.1 CDS ECs4498 NC_002695.1 4541762 4542808 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4541762..4542808 Escherichia coli O157:H7 str. Sakai 915556 NP_312526.1 CDS ECs4499 NC_002695.1 4542812 4543804 D similar to RFAC_ECOLI gi|1790051 (conserved in Escherichia coli K-12); ADP-heptose--LPS heptosyltransferase 4542812..4543804 Escherichia coli O157:H7 str. Sakai 915554 NP_312527.1 CDS ECs4500 NC_002695.1 4543801 4545009 D WaaL; similar to WaaL [Escherichia coli strain F653] gi|3821825|gb|AAC69661.1|; lipid A-core:surface polymer ligase 4543801..4545009 Escherichia coli O157:H7 str. Sakai 915553 NP_312528.1 CDS ECs4501 NC_002695.1 4545045 4546187 R WaaD; similar to WaaD [Escherichia coli strain F653] gi|3821826|gb|AAC69662.1|; lipopolysaccharide 1,2-N- acetylglucosaminetransferase complement(4545045..4546187) Escherichia coli O157:H7 str. Sakai 915551 NP_312529.1 CDS ECs4502 NC_002695.1 4546196 4547209 R WaaJ; similar to UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase WaaJ [Escherichia coli strain F653] gi|3821827|gb|AAC69663.1|; UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase complement(4546196..4547209) Escherichia coli O157:H7 str. Sakai 915550 NP_312530.1 CDS ECs4503 NC_002695.1 4547234 4547941 R similar to WaaY [Escherichia coli strain F653] gi|3821828|gb|AAC69664.1|; lipopolysaccharide core biosynthesis protein complement(4547234..4547941) Escherichia coli O157:H7 str. Sakai 915549 NP_312531.1 CDS ECs4504 NC_002695.1 4547967 4548974 R similar to WaaI (strain F653 R3 core type) [Escherichia coli] gi|3821829|gb|AAC69665.1; UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase complement(4547967..4548974) Escherichia coli O157:H7 str. Sakai 915548 NP_312532.2 CDS ECs4505 NC_002695.1 4549017 4549814 R similar to RFAP_ECOLI gi|1790060 (conserved in Escherichia coli K-12); RfaP protein complement(4549017..4549814) Escherichia coli O157:H7 str. Sakai 915546 NP_312533.1 CDS ECs4506 NC_002695.1 4549807 4550931 R similar to RFAG_ECOLI gi|1790061 (conserved in Escherichia coli K-12); glucosyltransferase I complement(4549807..4550931) Escherichia coli O157:H7 str. Sakai 915543 NP_312534.2 CDS ECs4507 NC_002695.1 4550928 4551950 R (conserved in Escherichia coli K-12); lipopolysaccharide core biosynthesis protein complement(4550928..4551950) Escherichia coli O157:H7 str. Sakai 915542 NP_312535.1 CDS ECs4508 NC_002695.1 4552399 4553676 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4552399..4553676 Escherichia coli O157:H7 str. Sakai 915541 NP_312536.1 CDS coaD NC_002695.1 4553684 4554163 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4553684..4554163 Escherichia coli O157:H7 str. Sakai 915539 NP_312537.1 CDS ECs4510 NC_002695.1 4554202 4555011 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(4554202..4555011) Escherichia coli O157:H7 str. Sakai 915538 NP_312538.1 CDS rpmG NC_002695.1 4555109 4555276 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(4555109..4555276) Escherichia coli O157:H7 str. Sakai 915536 NP_312539.1 CDS rpmB NC_002695.1 4555297 4555533 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(4555297..4555533) Escherichia coli O157:H7 str. Sakai 915534 NP_312540.1 CDS radC NC_002695.1 4555750 4556424 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(4555750..4556424) Escherichia coli O157:H7 str. Sakai 915533 NP_312541.2 CDS ECs4514 NC_002695.1 4556590 4557810 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4556590..4557810 Escherichia coli O157:H7 str. Sakai 915532 NP_312542.1 CDS dut NC_002695.1 4557791 4558246 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4557791..4558246 Escherichia coli O157:H7 str. Sakai 915531 NP_312543.2 CDS slmA NC_002695.1 4558353 4558949 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4558353..4558949 Escherichia coli O157:H7 str. Sakai 915529 NP_312544.1 CDS pyrE NC_002695.1 4558986 4559627 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(4558986..4559627) Escherichia coli O157:H7 str. Sakai 915528 NP_312545.1 CDS rph NC_002695.1 4559693 4560409 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4559693..4560409) Escherichia coli O157:H7 str. Sakai 915527 NP_312546.1 CDS ECs4519 NC_002695.1 4560536 4561399 D similar to YICC_ECOLI gi|1790075 (conserved in Escherichia coli K-12); hypothetical protein 4560536..4561399 Escherichia coli O157:H7 str. Sakai 915525 NP_312547.2 CDS dinD NC_002695.1 4561620 4562444 D similar to DIND_ECOLI gi|1790076 (conserved in Escherichia coli K-12); DNA-damage-inducible protein D 4561620..4562444 Escherichia coli O157:H7 str. Sakai 915524 NP_312548.2 CDS ECs4521 NC_002695.1 4562736 4563353 D similar to YICG_ECOLI gi|1790078 (conserved in Escherichia coli K-12); hypothetical protein 4562736..4563353 Escherichia coli O157:H7 str. Sakai 915523 NP_312549.2 CDS ligB NC_002695.1 4563350 4565032 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(4563350..4565032) Escherichia coli O157:H7 str. Sakai 915522 NP_944568.1 CDS ECs5537 NC_002695.1 4564893 4565150 R hypothetical protein complement(4564893..4565150) Escherichia coli O157:H7 str. Sakai 2693748 NP_312550.1 CDS gmk NC_002695.1 4565290 4565913 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4565290..4565913 Escherichia coli O157:H7 str. Sakai 915521 NP_312551.1 CDS rpoZ NC_002695.1 4565968 4566243 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4565968..4566243 Escherichia coli O157:H7 str. Sakai 915520 NP_312552.1 CDS ECs4525 NC_002695.1 4566262 4568370 D similar to SPOT_ECOLI gi|1790082 (conserved in Escherichia coli K-12); bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4566262..4568370 Escherichia coli O157:H7 str. Sakai 915518 NP_312553.1 CDS ECs4526 NC_002695.1 4568377 4569066 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4568377..4569066 Escherichia coli O157:H7 str. Sakai 915517 NP_312554.1 CDS ECs4527 NC_002695.1 4569072 4571153 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4569072..4571153 Escherichia coli O157:H7 str. Sakai 915516 NP_312555.1 CDS ECs4528 NC_002695.1 4571138 4571656 R hypothetical protein complement(4571138..4571656) Escherichia coli O157:H7 str. Sakai 915514 NP_312556.1 CDS ECs4529 NC_002695.1 4572007 4573212 R similar to GLTS_ECOLI gi|1790085 (conserved in Escherichia coli K-12); glutamate transport protein complement(4572007..4573212) Escherichia coli O157:H7 str. Sakai 915513 NP_312557.1 CDS ECs4530 NC_002695.1 4573492 4574883 D similar to YICE_ECOLI gi|1790087 (conserved in Escherichia coli K-12); transporter 4573492..4574883 Escherichia coli O157:H7 str. Sakai 915511 NP_312558.1 CDS ECs4531 NC_002695.1 4575004 4576713 D similar to YICH_ECOLI gi|1790088 (conserved in Escherichia coli K-12); hypothetical protein 4575004..4576713 Escherichia coli O157:H7 str. Sakai 915510 NP_312559.1 CDS ECs4532 NC_002695.1 4576766 4579084 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase complement(4576766..4579084) Escherichia coli O157:H7 str. Sakai 915508 NP_312560.2 CDS ECs4533 NC_002695.1 4579094 4580476 R may be involved in the transport of galactosides-pentoses-hexuronides; transporter complement(4579094..4580476) Escherichia coli O157:H7 str. Sakai 915507 NP_312561.1 CDS ECs4534 NC_002695.1 4581059 4582240 D similar to CP4-like integrases [Escherichia coli EDL933] gi|3414871|gb|AAC31482.1|, integrases e.g. [Shigella flexneri] gi|5532446|gb|AAD44730.1|AF141323_1; integrase 4581059..4582240 Escherichia coli O157:H7 str. Sakai 915505 NP_312562.1 CDS ECs4535 NC_002695.1 4582339 4582689 D similar to L0004 [Escherichia coli strain EDL933] gi|3414872|gb|AAC31483.1|, hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS911 gi|7465897|pir||T00224; hypothetical protein 4582339..4582689 Escherichia coli O157:H7 str. Sakai 915504 NP_312563.1 CDS ECs4536 NC_002695.1 4582702 4582884 D similar to L0005 [Escherichia coli strain EDL933] gi|3414873|gb|AAC31484.1|; hypothetical protein 4582702..4582884 Escherichia coli O157:H7 str. Sakai 915503 NP_312564.1 CDS ECs4537 NC_002695.1 4582902 4583555 D similar to L0006 [Escherichia coli strain EDL933] gi|3414874|gb|AAC31485.1|, hypothetical protein [Vibrio cholerae] gi|7960027|gb|AAF71187.1|AF179596_7; hypothetical protein 4582902..4583555 Escherichia coli O157:H7 str. Sakai 915502 NP_312565.1 CDS ECs4538 NC_002695.1 4583573 4583716 D similar to C-terminal parts of hypothetical proteins e.g. b2004 (YeeU) [Escherichia coli] gi|3025157|sp|P76364|YEEU_ECOLI; hypothetical protein 4583573..4583716 Escherichia coli O157:H7 str. Sakai 915501 NP_312566.1 CDS ECs4539 NC_002695.1 4583806 4584180 D similar to L0007 [Escherichia coli EDL933] gi|3414875|gb|AAC31486.1|, hypothetical proteins e.g. b2005 (yeeV) [Escherichia coli] gi|3025158|sp|P76365|YEEV_ECOLI; hypothetical protein 4583806..4584180 Escherichia coli O157:H7 str. Sakai 915500 NP_312567.1 CDS ECs4540 NC_002695.1 4584177 4584668 D similar to L0008 [Escherichia coli EDL933] gi|3414876|gb|AAC31487.1|, hypothetical protein [Escherichia coli D1114, O25:K10:H16] gi|4887094|gb|AAD32187.1|, b2006 (YeeW); hypothetical protein 4584177..4584668 Escherichia coli O157:H7 str. Sakai 915498 NP_312568.1 CDS ECs4541 NC_002695.1 4584680 4584877 D similar to L0009 [Escherichia coli strain EDL933] gi|3414877|gb|AAC31488.1|, hypothetical protein [Escherichia coli D1114, O25:K10:H16] gi|4887094|gb|AAD32187.1; hypothetical protein 4584680..4584877 Escherichia coli O157:H7 str. Sakai 915497 NP_312569.1 CDS ECs4542 NC_002695.1 4584962 4585303 D similar to L0010 [Escherichia coli strain EDL933] gi|3414878|gb|AAC31489.1|, PH01 [Escherichia coli D1114, O25:K10:H16] gi|4887092|gb|AAD32185.1|AF127177_3; hypothetical protein 4584962..4585303 Escherichia coli O157:H7 str. Sakai 915496 NP_312572.1 CDS ECs4545 NC_002695.1 4586059 4586460 D similar to L0013 [Escherichia coli EDL933] gi|3414881|gb|AAC31492.1|, hypothetical proteins e.g. Hp3 [Escherichia coli CFT073] gi|3661484|gb|AAC61715.1|; hypothetical protein 4586059..4586460 Escherichia coli O157:H7 str. Sakai 915492 NP_312573.1 CDS ECs4546 NC_002695.1 4586457 4586804 D similar to L0014 [Escherichia coli] gi|3414882|gb|AAC31493.1|, hypothetical proteins e.g. orf50 [Escherichia coli plasmid pB171] gi|6009426|dbj|BAA84885.1|; hypothetical protein 4586457..4586804 Escherichia coli O157:H7 str. Sakai 915490 NP_312574.1 CDS ECs4547 NC_002695.1 4586854 4588392 D similar to L0015 [Escherichia coli EDL933] gi|3414883|gb|AAC31494.1|, hypothetical proteins e.g. [Escherichia coli plasmid pEAF] gi|4808945|gb|AAD30027.1|AF119170_2; hypothetical protein 4586854..4588392 Escherichia coli O157:H7 str. Sakai 915489 NP_312575.1 CDS ECs4548 NC_002695.1 4588589 4588822 D similar to IS630 insertion element hypothetical protein gi|1143207|gb|AAA84873.1|; hypothetical protein 4588589..4588822 Escherichia coli O157:H7 str. Sakai 915488 NP_312577.1 CDS ECs4550 NC_002695.1 4589257 4590003 R similar to L0016 [Escherichia coli EDL933] gi|3414884|gb|AAC31495.1|, EspF [Escherichia coli E2348/69] gi|2865308|gb|AAC38400.1|; protein EspF complement(4589257..4590003) Escherichia coli O157:H7 str. Sakai 915286 NP_312578.1 CDS ECs4551 NC_002695.1 4590088 4590366 R similar to L0017 [Escherichia coli EDL933] gi|3414885|gb|AAC31496.1|, hypothetical protein [Escherichia coli] gi|2809428|gb|AAC28566.1|; hypothetical protein complement(4590088..4590366) Escherichia coli O157:H7 str. Sakai 915301 NP_312579.1 CDS ECs4552 NC_002695.1 4590372 4590593 R similar to EscF [Escherichia coli] gi|2865306|gb|AAC38398.1|, L0018 [Escherichia coli EDL933] gi|3414886|gb|AAC31497.1|; protein EscF complement(4590372..4590593) Escherichia coli O157:H7 str. Sakai 915302 NP_312580.1 CDS ECs4553 NC_002695.1 4590629 4591036 R similar to L0019 [Escherichia coli EDL933] gi|3414887|gb|AAC31498.1|, hypothetical proteins e.g. Orf27 [Escherichia coli E2348/69] gi|2865305|gb|AAC38397.1|; hypothetical protein complement(4590629..4591036) Escherichia coli O157:H7 str. Sakai 915483 NP_312581.1 CDS ECs4554 NC_002695.1 4591043 4591981 R secreted protein; similar to EspB proteins e.g. EspB(L0020) [Escherichia coli EDL933] gi|1657263|emb|CAA65654.1|; protein EspB complement(4591043..4591981) Escherichia coli O157:H7 str. Sakai 915476 NP_312582.1 CDS ECs4555 NC_002695.1 4592002 4593126 R secreted protein; similar to L0021 [Escherichia coli EDL933] gi|3414889|gb|AAC31500.1|, EspD proteins e.g. gi|3688279|emb|CAA76909.1|; protein EspD complement(4592002..4593126) Escherichia coli O157:H7 str. Sakai 915475 NP_312583.1 CDS ECs4556 NC_002695.1 4593139 4593717 R secreted protein; similar to EspA protein (L0022) [Escherichia coli] gi|3115184|emb|CAA73506.1|, EspA proteins e.g. gi|2388623|gb|AAB71083.1|; protein EspA complement(4593139..4593717) Escherichia coli O157:H7 str. Sakai 915474 NP_312584.1 CDS ECs4557 NC_002695.1 4593776 4594831 R similar to SepL (L0023) [Escherichia coli EDL933] gi|3115183|emb|CAA73505.1|, SepL proteins e.g. gi|2865301|gb|AAC38393.1|; type III secretion system protein; SepL complement(4593776..4594831) Escherichia coli O157:H7 str. Sakai 915473 NP_312585.1 CDS ECs4558 NC_002695.1 4594974 4596194 D similar to Pas (L0024) [Escherichia coli EDL933] gi|3115182|emb|CAA73504.1|, EscD proteins e.g. gi|3341420|emb|CAA74170.1|; type III secretion system protein; EscD 4594974..4596194 Escherichia coli O157:H7 str. Sakai 915472 NP_312586.1 CDS ECs4559 NC_002695.1 4596458 4599262 R similar to Gamma intimin (L0025) [Escherichia coli strain EDL933] gi|3414893|gb|AAC31504.1|; gamma intimin complement(4596458..4599262) Escherichia coli O157:H7 str. Sakai 915471 NP_312587.1 CDS ECs4560 NC_002695.1 4599322 4599792 R chaperon of Tir; similar to CesT [Escherichia coli O157:H7 strain HA1] gi|975876|gb|AAB00110.1|, CesT proteins [Escherichia coli] gi|140611|sp|P21244|YEAE_ECOLI; protein CesT complement(4599322..4599792) Escherichia coli O157:H7 str. Sakai 915463 NP_312588.1 CDS ECs4561 NC_002695.1 4599930 4601606 R similar to translocated intimin receptor Tir (L0027) [Escherichia coli O157:H7 strain EDL933] gi|3414895|gb|AAC31506.1|; hypothetical protein complement(4599930..4601606) Escherichia coli O157:H7 str. Sakai 915465 NP_312589.1 CDS ECs4562 NC_002695.1 4602030 4602641 R similar to L0028 [Escherichia coli O157:H7 strain EDL933] gi|3414896|gb|AAC31507.1|, hypothetical protein [Escherichia coli] gi|3249026|gb|AAC69313.1|; hypothetical protein complement(4602030..4602641) Escherichia coli O157:H7 str. Sakai 915466 NP_312590.1 CDS ECs4563 NC_002695.1 4602907 4603290 D similar to L0029 [Escherichia coli O157:H7 strain EDL933] gi|3414897|gb|AAC31508.1|, rOrf10 [Escherichia coli] gi|2865295|gb|AAC38388.1|; hypothetical protein 4602907..4603290 Escherichia coli O157:H7 str. Sakai 915468 NP_312591.1 CDS ECs4564 NC_002695.1 4603488 4603994 R similar to L0030 [Escherichia coli O157:H7 strain EDL933] gi|3414898|gb|AAC31509.1|, Orf18 [Escherichia coli] gi|2865294|gb|AAC38387.1|; hypothetical protein complement(4603488..4603994) Escherichia coli O157:H7 str. Sakai 915470 NP_944569.1 CDS ECs5539 NC_002695.1 4603740 4603943 D hypothetical protein 4603740..4603943 Escherichia coli O157:H7 str. Sakai 2693785 NP_312592.1 CDS ECs4565 NC_002695.1 4604025 4604942 R similar to L0031 [Escherichia coli O157:H7 strain EDL933] gi|3414899|gb|AAC31510.1|, SepQ [Escherichia coli strain E2348/69] gi|2865293|gb|AAC38386.1|; type III secretion system protein; SepQ complement(4604025..4604942) Escherichia coli O157:H7 str. Sakai 915469 NP_312593.1 CDS ECs4566 NC_002695.1 4604905 4605321 R similar to Orf16 [Escherichia coli strain E2348/69] gi|2865292|gb|AAC38385.1|, L0032 [Escherichia coli O157:H7 strain EDL933] gi|3414900|gb|AAC31511.1|; hypothetical protein complement(4604905..4605321) Escherichia coli O157:H7 str. Sakai 915467 NP_312594.1 CDS ECs4567 NC_002695.1 4605314 4605691 R similar to L0033 [Escherichia coli O157:H7 strain EDL933] gi|3414901|gb|AAC31512.1|; hypothetical protein complement(4605314..4605691) Escherichia coli O157:H7 str. Sakai 915464 NP_312595.1 CDS ECs4568 NC_002695.1 4605694 4607034 R similar to EscN (L00349 [Escherichia coli O157:H7 strain EDL933] gi|3414902|gb|AAC31513.1|; type III secretion system protein; EscN complement(4605694..4607034) Escherichia coli O157:H7 str. Sakai 915448 NP_312596.1 CDS ECs4569 NC_002695.1 4607018 4609045 R similar to EscV (L0035) [Escherichia coli O157:H7 strain EDL933] gi|3414903|gb|AAC31514.1|; hypothetical protein complement(4607018..4609045) Escherichia coli O157:H7 str. Sakai 915449 NP_312597.1 CDS ECs4570 NC_002695.1 4609042 4609395 R similar to Orf12 [Escherichia coli strain E2348/69] gi|2865288|gb|AAC38381.1|, L0036 [Escherichia coli O157:H7 strain EDL933] gi|3414904|gb|AAC31515.1|; hypothetical protein complement(4609042..4609395) Escherichia coli O157:H7 str. Sakai 915452 NP_312598.1 CDS ECs4571 NC_002695.1 4609580 4609879 D similar to SepZ proteins e.g. [Escherichia coli O157:H7 strain EDL933] gi|3414905|gb|AAC31516.1|; type III secretion system protein; SepZ 4609580..4609879 Escherichia coli O157:H7 str. Sakai 915454 NP_312599.1 CDS ECs4572 NC_002695.1 4609912 4610340 D similar to L0038 [Escherichia coli O157:H7 strain EDL933] gi|3414906|gb|AAC31517.1|, rOrf8 [Escherichia coli E2348/69] gi|2865287|gb|AAC38380.1|; hypothetical protein 4609912..4610340 Escherichia coli O157:H7 str. Sakai 915456 NP_312600.1 CDS ECs4573 NC_002695.1 4610343 4610915 D similar to EscJ [Escherichia coli strain E2348/69] gi|2865286|gb|AAC38379.1|, L0039 (EscJ) [Escherichia coli O157:H7 strain EDL933] gi|3414907|gb|AAC31518.1|; type III secretion system protein; EscJ 4610343..4610915 Escherichia coli O157:H7 str. Sakai 915458 NP_312601.1 CDS ECs4574 NC_002695.1 4610921 4611376 D similar to SepD (L0040) [Escherichia coli O157:H7 strain EDL933] gi|3414908|gb|AAC31519.1|, SepD proteins e.g. [Escherichia coli strain E2348/69] gi|886476|emb|CAA90273.1|; type III secretion system protein; SepD 4610921..4611376 Escherichia coli O157:H7 str. Sakai 915462 NP_312602.1 CDS ECs4575 NC_002695.1 4611376 4612914 D similar to EscC (L0041) [Escherichia coli O157:H7 strain EDL933] gi|3414909|gb|AAC31520.1|; type III secretion system protein; EscC 4611376..4612914 Escherichia coli O157:H7 str. Sakai 915461 NP_312603.1 CDS ECs4576 NC_002695.1 4612928 4613383 D similar to CesD (L0042) [Escherichia coli O157:H7 strain EDL933] gi|3414910|gb|AAC31521.1|; type III secretion system protein; CesD 4612928..4613383 Escherichia coli O157:H7 str. Sakai 915460 NP_312604.1 CDS ECs4577 NC_002695.1 4613767 4614180 R similar to L0043 [Escherichia coli O157:H7 strain EDL933] gi|3414911|gb|AAC31522.1|, Orf11 [Escherichia coli strain E2348/69] gi|2865282|gb|AAC38375.1|; hypothetical protein complement(4613767..4614180) Escherichia coli O157:H7 str. Sakai 915459 NP_312605.1 CDS ECs4578 NC_002695.1 4614235 4614606 R similar to L0044 [Escherichia coli O157:H7 strain EDL933] gi|3414912|gb|AAC31523.1|, Orf10 [Escherichia coli strain E2348/69] gi|2865281|gb|AAC38374.1|; negative regulator GrlR complement(4614235..4614606) Escherichia coli O157:H7 str. Sakai 915455 NP_312606.1 CDS ECs4579 NC_002695.1 4614802 4615260 D similar to L0045 [Escherichia coli O157:H7 strain EDL933] gi|3414913|gb|AAC31524.1|, rOrf3 [Escherichia coli strain E2348/69] gi|2865280|gb|AAC38373.1|; hypothetical protein 4614802..4615260 Escherichia coli O157:H7 str. Sakai 915453 NP_312607.1 CDS ECs4580 NC_002695.1 4615257 4616294 R member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli; secretion system apparatus protein SsaU complement(4615257..4616294) Escherichia coli O157:H7 str. Sakai 915451 NP_312608.1 CDS ECs4581 NC_002695.1 4616287 4617063 R similar to EscT (L0047) [Escherichia coli O157:H7 strain EDL933] gi|3414915|gb|AAC31526.1|; type III secretion system protein; EscT complement(4616287..4617063) Escherichia coli O157:H7 str. Sakai 915450 NP_312609.1 CDS ECs4582 NC_002695.1 4617063 4617332 R similar to EscS (L0048) [Escherichia coli O157:H7 strain EDL933] gi|3414916|gb|AAC31527.1|; type III secretion system protein; EscS complement(4617063..4617332) Escherichia coli O157:H7 str. Sakai 915447 NP_312610.1 CDS ECs4583 NC_002695.1 4617332 4617985 R part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response; type III secretion system protein complement(4617332..4617985) Escherichia coli O157:H7 str. Sakai 915446 NP_312611.1 CDS ECs4584 NC_002695.1 4617990 4618685 R similar to L0050 [Escherichia coli O157:H7 strain EDL933] gi|3414918|gb|AAC31529.1|, Orf5 [Escherichia coli strain E2348/69] gi|2865275|gb|AAC38368.1|; hypothetical protein complement(4617990..4618685) Escherichia coli O157:H7 str. Sakai 915437 NP_312612.1 CDS ECs4585 NC_002695.1 4618630 4619229 R similar to L0051 [Escherichia coli O157:H7 strain EDL933] gi|3414919|gb|AAC31530.1|, Orf4 [Escherichia coli strain E2348/69] gi|2865274|gb|AAC38367.1|; hypothetical protein complement(4618630..4619229) Escherichia coli O157:H7 str. Sakai 915441 NP_312613.1 CDS ECs4586 NC_002695.1 4619226 4619549 R similar to Orf3 [Escherichia coli E2348/69] gi|2865273|gb|AAC38366.1|, L0052 [Escherichia coli O157:H7 strain EDL933] gi|3414920|gb|AAC31531.1|; hypothetical protein complement(4619226..4619549) Escherichia coli O157:H7 str. Sakai 915457 NP_312614.1 CDS ECs4587 NC_002695.1 4619553 4619771 R similar to Orf2 [Escherichia coli strain E2348/69] gi|2865272|gb|AAC38365.1|, L0053 [Escherichia coli O157:H7 strain EDL933] gi|3414921|gb|AAC31532.1|; hypothetical protein complement(4619553..4619771) Escherichia coli O157:H7 str. Sakai 915444 NP_312615.1 CDS ECs4588 NC_002695.1 4619786 4620175 R similar to L0054 [Escherichia coli O157:H7 strain EDL933] gi|3414922|gb|AAC31533.1|, Ler [Escherichia coli strain E2348/69] gi|2865271|gb|AAC38364.1|; hypothetical protein complement(4619786..4620175) Escherichia coli O157:H7 str. Sakai 915445 NP_312617.1 CDS ECs4590 NC_002695.1 4621420 4622616 D similar to L0055 [Escherichia coli O157:H7 strain EDL933] gi|3414923|gb|AAC31534.1|, rOrf2, EspG [Escherichia coli strain E2348/69] gi|2865270|gb|AAC38363.1|; protein EspG 4621420..4622616 Escherichia coli O157:H7 str. Sakai 915442 NP_312618.1 CDS ECs4591 NC_002695.1 4622744 4623562 D similar to L0056 [Escherichia coli O157:H7 strain EDL933] gi|3414924|gb|AAC31535.1|, rOrf1 [Escherichia coli strain E2348/69] gi|2865269|gb|AAC38362.1|; hypothetical protein 4622744..4623562 Escherichia coli O157:H7 str. Sakai 915440 NP_312619.1 CDS ECs4592 NC_002695.1 4623876 4624109 R hypothetical protein complement(4623876..4624109) Escherichia coli O157:H7 str. Sakai 915439 NP_312620.1 CDS ECs4593 NC_002695.1 4624334 4624528 R hypothetical protein complement(4624334..4624528) Escherichia coli O157:H7 str. Sakai 915438 NP_312621.1 CDS ECs4594 NC_002695.1 4624582 4625505 D similar to YICL_ECOLI gi|1790092 (conserved in Escherichia coli K-12); permease transporter 4624582..4625505 Escherichia coli O157:H7 str. Sakai 915436 NP_312622.1 CDS ECs4595 NC_002695.1 4625509 4626327 R similar to NLPA_ECOLI gi|1790093 (conserved in Escherichia coli K-12); hypothetical protein complement(4625509..4626327) Escherichia coli O157:H7 str. Sakai 915435 NP_944570.1 CDS ECs5540 NC_002695.1 4626480 4626842 D hypothetical protein 4626480..4626842 Escherichia coli O157:H7 str. Sakai 2693786 NP_312623.2 CDS nepI NC_002695.1 4626883 4628073 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(4626883..4628073) Escherichia coli O157:H7 str. Sakai 915429 NP_312624.1 CDS ECs4597 NC_002695.1 4628307 4628660 D similar to hypothetical proteins e.g. NMA0565 [Neisseria meningitidis] gi|7379302|emb|CAB83857.1; hypothetical protein 4628307..4628660 Escherichia coli O157:H7 str. Sakai 913046 NP_312625.1 CDS ECs4598 NC_002695.1 4628644 4628967 D similar to DNA-binding protein [Neisseria meningitidis] gi|7379301|emb|CAB83856.1; DNA-binding protein 4628644..4628967 Escherichia coli O157:H7 str. Sakai 913063 NP_312626.1 CDS ECs4599 NC_002695.1 4629083 4629562 R similar to YICN_ECOLI gi|1790096 (conserved in Escherichia coli K-12); hypothetical protein complement(4629083..4629562) Escherichia coli O157:H7 str. Sakai 913119 NP_312627.1 CDS ECs4600 NC_002695.1 4629588 4630013 R similar to YICO_ECOLI gi|1790097; hypothetical protein complement(4629588..4630013) Escherichia coli O157:H7 str. Sakai 913122 NP_312628.1 CDS ECs4601 NC_002695.1 4629926 4630999 R similar to YICO_ECOLI gi|1790097; hypothetical protein complement(4629926..4630999) Escherichia coli O157:H7 str. Sakai 915434 NP_312629.1 CDS ECs4602 NC_002695.1 4631096 4632862 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4631096..4632862 Escherichia coli O157:H7 str. Sakai 915433 NP_312630.1 CDS uhpT NC_002695.1 4632908 4634299 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(4632908..4634299) Escherichia coli O157:H7 str. Sakai 915432 NP_312631.1 CDS ECs4604 NC_002695.1 4634437 4635759 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(4634437..4635759) Escherichia coli O157:H7 str. Sakai 915431 NP_312632.2 CDS ECs4605 NC_002695.1 4635766 4637268 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(4635766..4637268) Escherichia coli O157:H7 str. Sakai 915430 NP_312633.1 CDS ECs4606 NC_002695.1 4637268 4637858 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; UhpA family transcriptional regulator complement(4637268..4637858) Escherichia coli O157:H7 str. Sakai 915428 NP_312634.1 CDS ECs4607 NC_002695.1 4638020 4639012 R hypothetical protein complement(4638020..4639012) Escherichia coli O157:H7 str. Sakai 915427 NP_312635.1 CDS ECs4608 NC_002695.1 4639139 4639453 R hypothetical protein complement(4639139..4639453) Escherichia coli O157:H7 str. Sakai 915426 NP_312636.1 CDS ECs4609 NC_002695.1 4639731 4640213 R hypothetical protein complement(4639731..4640213) Escherichia coli O157:H7 str. Sakai 915425 NP_312637.1 CDS ECs4610 NC_002695.1 4640361 4641014 R hypothetical protein complement(4640361..4641014) Escherichia coli O157:H7 str. Sakai 915424 NP_312638.1 CDS ECs4611 NC_002695.1 4641277 4641567 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(4641277..4641567) Escherichia coli O157:H7 str. Sakai 915423 NP_312639.1 CDS ECs4612 NC_002695.1 4641571 4643259 R catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase catalytic subunit complement(4641571..4643259) Escherichia coli O157:H7 str. Sakai 915422 NP_312640.1 CDS ECs4613 NC_002695.1 4643365 4643463 R similar to IVBL_ECOLI gi|1790106 (conserved in Escherichia coli K-12); ilvB operon leader peptide complement(4643365..4643463) Escherichia coli O157:H7 str. Sakai 915421 NP_944571.1 CDS ECs5541 NC_002695.1 4643450 4643740 D hypothetical protein 4643450..4643740 Escherichia coli O157:H7 str. Sakai 2693787 NP_312641.1 CDS emrD NC_002695.1 4644391 4645581 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4644391..4645581 Escherichia coli O157:H7 str. Sakai 915420 NP_312642.1 CDS ECs4615 NC_002695.1 4645589 4646086 R similar to YIDF_ECOLI gi|1790108 (conserved in Escherichia coli K-12); transcriptional regulator complement(4645589..4646086) Escherichia coli O157:H7 str. Sakai 915419 NP_312643.1 CDS ECs4616 NC_002695.1 4646083 4646445 R similar to YIDG_ECOLI gi|1790109 (conserved in Escherichia coli K-12); hypothetical protein complement(4646083..4646445) Escherichia coli O157:H7 str. Sakai 915418 NP_312644.1 CDS ECs4617 NC_002695.1 4646435 4646782 R similar to YIDH_ECOLI gi|1790110 (conserved in Escherichia coli K-12); hypothetical protein complement(4646435..4646782) Escherichia coli O157:H7 str. Sakai 915417 NP_312645.1 CDS ECs4618 NC_002695.1 4646891 4647340 D similar to YIDI_ECOLI gi|1790111 (conserved in Escherichia coli K-12); hypothetical protein 4646891..4647340 Escherichia coli O157:H7 str. Sakai 915415 NP_312646.1 CDS ECs4619 NC_002695.1 4647387 4648880 R similar to YIDJ_ECOLI gi|1790112 (conserved in Escherichia coli K-12); sulfatase complement(4647387..4648880) Escherichia coli O157:H7 str. Sakai 913018 NP_312647.1 CDS ECs4620 NC_002695.1 4648877 4650592 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK complement(4648877..4650592) Escherichia coli O157:H7 str. Sakai 913019 NP_312648.1 CDS ECs4621 NC_002695.1 4650729 4651652 D similar to YIDL_ECOLI gi|1790114 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 4650729..4651652 Escherichia coli O157:H7 str. Sakai 915411 NP_312649.1 CDS ECs4622 NC_002695.1 4651649 4652971 R similar to GLVG_ECOLI gi|1790115 (conserved in Escherichia coli K-12); 6-phospho-beta-glucosidase complement(4651649..4652971) Escherichia coli O157:H7 str. Sakai 915416 NP_312650.2 CDS ECs4623 NC_002695.1 4652971 4654587 R similar to GLVC_ECOLI gi|1790117 (conserved in Escherichia coli K-12); PTS system arbutin-like IIC component complement(4652971..4654587) Escherichia coli O157:H7 str. Sakai 915414 NP_312651.1 CDS ECs4624 NC_002695.1 4654883 4655599 D similar to YIDP_ECOLI gi|1790118 (conserved in Escherichia coli K-12); transcriptional regulator 4654883..4655599 Escherichia coli O157:H7 str. Sakai 915413 NP_312652.2 CDS ECs4625 NC_002695.1 4655596 4657257 R similar to YIDE_ECOLI gi|1790119 (conserved in Escherichia coli K-12); hypothetical protein complement(4655596..4657257) Escherichia coli O157:H7 str. Sakai 915412 NP_312653.2 CDS ECs4626 NC_002695.1 4657453 4657881 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(4657453..4657881) Escherichia coli O157:H7 str. Sakai 915410 NP_312654.1 CDS ECs4627 NC_002695.1 4657993 4658406 R heat shock protein; with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(4657993..4658406) Escherichia coli O157:H7 str. Sakai 915409 NP_312655.2 CDS ECs4628 NC_002695.1 4658712 4659044 D similar to YIDQ_ECOLI gi|1790123 (conserved in Escherichia coli K-12); hypothetical protein 4658712..4659044 Escherichia coli O157:H7 str. Sakai 915408 NP_312656.1 CDS ECs4629 NC_002695.1 4659046 4660296 R similar to YIDR_ECOLI gi|1790124 (conserved in Escherichia coli K-12); hypothetical protein complement(4659046..4660296) Escherichia coli O157:H7 str. Sakai 915407 NP_312657.2 CDS ECs4630 NC_002695.1 4660361 4661425 D FAD/NAD(P)-binding domain; oxidoreductase 4660361..4661425 Escherichia coli O157:H7 str. Sakai 915406 NP_312658.1 CDS ECs4631 NC_002695.1 4661671 4662327 D similar YIDX_ECOLI gi|1790130; hypothetical protein 4661671..4662327 Escherichia coli O157:H7 str. Sakai 915405 NP_312659.1 CDS ECs4632 NC_002695.1 4662373 4663185 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(4662373..4663185) Escherichia coli O157:H7 str. Sakai 915404 NP_312660.2 CDS ECs4633 NC_002695.1 4663300 4663698 R similar to YIDB_ECOLI gi|1790133 (conserved in Escherichia coli K-12); hypothetical protein complement(4663300..4663698) Escherichia coli O157:H7 str. Sakai 915403 NP_312661.1 CDS gyrB NC_002695.1 4663938 4666352 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(4663938..4666352) Escherichia coli O157:H7 str. Sakai 915402 NP_312662.1 CDS recF NC_002695.1 4666381 4667454 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(4666381..4667454) Escherichia coli O157:H7 str. Sakai 915400 NP_312663.1 CDS ECs4636 NC_002695.1 4667454 4668554 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(4667454..4668554) Escherichia coli O157:H7 str. Sakai 915391 NP_312664.1 CDS dnaA NC_002695.1 4668559 4669962 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(4668559..4669962) Escherichia coli O157:H7 str. Sakai 913016 NP_312665.1 CDS rpmH NC_002695.1 4670569 4670709 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4670569..4670709 Escherichia coli O157:H7 str. Sakai 915396 NP_312666.1 CDS rnpA NC_002695.1 4670726 4671085 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4670726..4671085 Escherichia coli O157:H7 str. Sakai 915401 NP_312667.1 CDS ECs4640 NC_002695.1 4671309 4672955 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4671309..4672955 Escherichia coli O157:H7 str. Sakai 915399 NP_312668.1 CDS trmE NC_002695.1 4673061 4674425 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4673061..4674425 Escherichia coli O157:H7 str. Sakai 915398 NP_312669.1 CDS ECs4642 NC_002695.1 4674575 4674805 R hypothetical protein complement(4674575..4674805) Escherichia coli O157:H7 str. Sakai 915397 NP_312670.1 CDS ECs4643 NC_002695.1 4674756 4676744 R similar to ankyrin-like regulatory protein [Escherichia coli] gi|418526|sp|P23325|APR_ECOLI, ShET2 enterotoxin [Shigella flexneri] gi|1109754|emb|CAA90938.1|; hypothetical protein complement(4674756..4676744) Escherichia coli O157:H7 str. Sakai 915395 NP_312671.1 CDS ECs4644 NC_002695.1 4677144 4677218 D similar to TNAL_ECOLI gi|1790143 (conserved in Escherichia coli K-12); tryptophanase leader peptide 4677144..4677218 Escherichia coli O157:H7 str. Sakai 915394 NP_312672.2 CDS tnaA NC_002695.1 4677439 4678854 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4677439..4678854 Escherichia coli O157:H7 str. Sakai 915393 NP_312673.1 CDS ECs4646 NC_002695.1 4678945 4680192 D tryptophan transporter of low affinity; tryptophan permease TnaB 4678945..4680192 Escherichia coli O157:H7 str. Sakai 915392 NP_312674.1 CDS ECs4647 NC_002695.1 4680324 4681499 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4680324..4681499 Escherichia coli O157:H7 str. Sakai 915390 NP_312675.1 CDS ECs4648 NC_002695.1 4681474 4682433 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4681474..4682433 Escherichia coli O157:H7 str. Sakai 915377 NP_312676.1 CDS ECs4649 NC_002695.1 4682578 4683339 D similar to YIEE_ECOLI gi|1790148 (conserved in Escherichia coli K-12); hypothetical protein 4682578..4683339 Escherichia coli O157:H7 str. Sakai 915379 NP_312677.1 CDS ECs4650 NC_002695.1 4683361 4683927 D similar to YIEF_ECOLI gi|1790149 (conserved in Escherichia coli K-12); hypothetical protein 4683361..4683927 Escherichia coli O157:H7 str. Sakai 915385 NP_312678.1 CDS ECs4651 NC_002695.1 4683981 4685318 R similar to YIEG_ECOLI gi|1790150 (conserved in Escherichia coli K-12); membrane/transport protein complement(4683981..4685318) Escherichia coli O157:H7 str. Sakai 915383 NP_312679.1 CDS ECs4652 NC_002695.1 4685484 4686149 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4685484..4686149 Escherichia coli O157:H7 str. Sakai 915386 NP_312680.1 CDS ECs4653 NC_002695.1 4686286 4688694 R similar to hypothetical protein [Plasmodium falciparum] gi|8052285|emb|CAB39037.2|, restriction-modification enzyme R subunits [Mycoplasma pulmonis] e.g. gi|1363459|pir||S49394; hypothetical protein complement(4686286..4688694) Escherichia coli O157:H7 str. Sakai 915389 NP_312681.1 CDS ECs4654 NC_002695.1 4688995 4689666 D hypothetical protein 4688995..4689666 Escherichia coli O157:H7 str. Sakai 915388 NP_312682.1 CDS ECs4655 NC_002695.1 4689712 4690182 D hypothetical protein 4689712..4690182 Escherichia coli O157:H7 str. Sakai 915387 NP_312683.1 CDS ECs4656 NC_002695.1 4690281 4690460 R hypothetical protein complement(4690281..4690460) Escherichia coli O157:H7 str. Sakai 915384 NP_312684.1 CDS ECs4657 NC_002695.1 4690651 4693035 R similar to hypothetical protein [Plasmodium falciparum] gi|8052290|emb|CAB39073.2|; hypothetical protein complement(4690651..4693035) Escherichia coli O157:H7 str. Sakai 915382 NP_944572.1 CDS ECs5542 NC_002695.1 4693117 4693323 R hypothetical protein complement(4693117..4693323) Escherichia coli O157:H7 str. Sakai 2693784 NP_312686.1 CDS ECs4659 NC_002695.1 4693425 4693604 R hypothetical protein complement(4693425..4693604) Escherichia coli O157:H7 str. Sakai 915380 NP_312687.1 CDS ECs4660 NC_002695.1 4693561 4694286 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(4693561..4694286) Escherichia coli O157:H7 str. Sakai 915378 NP_312688.1 CDS pstB NC_002695.1 4694301 4695074 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(4694301..4695074) Escherichia coli O157:H7 str. Sakai 915370 NP_312689.1 CDS pstA NC_002695.1 4695257 4696147 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PtsA complement(4695257..4696147) Escherichia coli O157:H7 str. Sakai 915367 NP_312690.1 CDS pstC NC_002695.1 4696147 4697106 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PstC complement(4696147..4697106) Escherichia coli O157:H7 str. Sakai 915372 NP_312691.1 CDS ECs4664 NC_002695.1 4697193 4698233 R similar to PSTS_ECOLI gi|2367271 (conserved in Escherichia coli K-12); phosphate ABC transporter substrate-binding protein complement(4697193..4698233) Escherichia coli O157:H7 str. Sakai 915373 NP_312692.1 CDS ECs4665 NC_002695.1 4698445 4699527 R similar to fimbrial proteins e.g. [Salmonella typhimurium] gi|1170818|sp|P43663|LPFD_SALTY, [Escherichia coli] gi|3915422|sp|P75858|YCBT_ECOLI; fimbrial protein complement(4698445..4699527) Escherichia coli O157:H7 str. Sakai 915374 NP_312693.1 CDS ECs4666 NC_002695.1 4699555 4700625 R similar to fimbrial proteins e.g. [Escherichia coli] gi|3915422|sp|P75858|YCBT_ECOLI, [Salmonella typhimurium] gi|1170818|sp|P43663|LPFD_SALTY; fimbrial protein complement(4699555..4700625) Escherichia coli O157:H7 str. Sakai 915376 NP_312694.1 CDS ECs4667 NC_002695.1 4700637 4703171 R similar to outer membrane usher protein precursors e.g. [Salmonella typhimurium] gi|1170817|sp|P43662|LPFC_SALTY, [Escherichia coli] gi|2829634|sp|P75857|YCBS_ECOLI; outer membrane usher protein complement(4700637..4703171) Escherichia coli O157:H7 str. Sakai 915375 NP_312695.1 CDS ECs4668 NC_002695.1 4703193 4703354 R similar to fimbrial chaperone e.g. gi|1169720|sp|P46008|FOCC_ECOLI; hypothetical protein complement(4703193..4703354) Escherichia coli O157:H7 str. Sakai 915371 NP_312696.1 CDS ECs4669 NC_002695.1 4703495 4703878 R similar to fimbrial chaperones e.g. [Salmonella typhimurium] gi|1170816|sp|P43661|LPFB_SALTY; fimbrial chaperone complement(4703495..4703878) Escherichia coli O157:H7 str. Sakai 915369 NP_312697.1 CDS ECs4670 NC_002695.1 4703982 4704584 R similar to type 1 fimbrial proteins e.g. [Salmonella enteritidis] gi|913907|gb|AAB33536.1|; type 1 fimbrial protein complement(4703982..4704584) Escherichia coli O157:H7 str. Sakai 915368 NP_312698.1 CDS ECs4671 NC_002695.1 4705284 4707113 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(4705284..4707113) Escherichia coli O157:H7 str. Sakai 915347 NP_312699.1 CDS glmU NC_002695.1 4707275 4708645 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(4707275..4708645) Escherichia coli O157:H7 str. Sakai 915349 NP_312700.1 CDS atpC NC_002695.1 4708997 4709416 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(4708997..4709416) Escherichia coli O157:H7 str. Sakai 915356 NP_312701.1 CDS ECs4674 NC_002695.1 4709437 4710819 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The subunit beta is a regulatory subunit; ATP synthase F0F1 subunit beta complement(4709437..4710819) Escherichia coli O157:H7 str. Sakai 915359 NP_312702.1 CDS ECs4675 NC_002695.1 4710846 4711709 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(4710846..4711709) Escherichia coli O157:H7 str. Sakai 915357 NP_312703.1 CDS ECs4676 NC_002695.1 4711760 4713301 R produces ATP from ADP in the presence of a proton gradient across the membrane; the subunit alpha is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(4711760..4713301) Escherichia coli O157:H7 str. Sakai 915345 NP_312704.1 CDS ECs4677 NC_002695.1 4713314 4713847 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(4713314..4713847) Escherichia coli O157:H7 str. Sakai 913118 NP_312705.1 CDS ECs4678 NC_002695.1 4713862 4714332 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(4713862..4714332) Escherichia coli O157:H7 str. Sakai 915334 NP_312706.1 CDS ECs4679 NC_002695.1 4714394 4714633 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(4714394..4714633) Escherichia coli O157:H7 str. Sakai 915336 NP_312707.1 CDS ECs4680 NC_002695.1 4714680 4715495 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(4714680..4715495) Escherichia coli O157:H7 str. Sakai 915337 NP_312708.2 CDS ECs4681 NC_002695.1 4715504 4715884 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(4715504..4715884) Escherichia coli O157:H7 str. Sakai 915341 NP_312709.1 CDS gidB NC_002695.1 4716501 4717124 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4716501..4717124) Escherichia coli O157:H7 str. Sakai 915344 NP_312710.1 CDS ECs4683 NC_002695.1 4717188 4719077 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(4717188..4719077) Escherichia coli O157:H7 str. Sakai 915333 NP_312711.1 CDS ECs4684 NC_002695.1 4719456 4719899 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4719456..4719899) Escherichia coli O157:H7 str. Sakai 915324 NP_312712.1 CDS ECs4685 NC_002695.1 4719989 4720447 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; AsnC family transcriptional regulator complement(4719989..4720447) Escherichia coli O157:H7 str. Sakai 915327 NP_312713.1 CDS ECs4686 NC_002695.1 4720599 4721591 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4720599..4721591 Escherichia coli O157:H7 str. Sakai 915329 NP_312714.1 CDS yieM NC_002695.1 4721596 4723047 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4721596..4723047) Escherichia coli O157:H7 str. Sakai 915332 NP_312715.2 CDS ECs4688 NC_002695.1 4723041 4724537 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4723041..4724537) Escherichia coli O157:H7 str. Sakai 915331 NP_312716.1 CDS trkD NC_002695.1 4724760 4726628 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4724760..4726628 Escherichia coli O157:H7 str. Sakai 915317 NP_312717.1 CDS ECs4690 NC_002695.1 4726795 4727214 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4726795..4727214 Escherichia coli O157:H7 str. Sakai 915320 NP_312718.1 CDS ECs4691 NC_002695.1 4727222 4728727 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; sugar ABC transporter ATP-binding protein 4727222..4728727 Escherichia coli O157:H7 str. Sakai 915326 NP_312719.1 CDS rbsC NC_002695.1 4728732 4729697 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4728732..4729697 Escherichia coli O157:H7 str. Sakai 915328 NP_312720.1 CDS ECs4693 NC_002695.1 4729722 4730612 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4729722..4730612 Escherichia coli O157:H7 str. Sakai 915325 NP_312721.1 CDS ECs4694 NC_002695.1 4730738 4731667 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4730738..4731667 Escherichia coli O157:H7 str. Sakai 915323 NP_312722.1 CDS ECs4695 NC_002695.1 4731671 4732663 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4731671..4732663 Escherichia coli O157:H7 str. Sakai 915322 NP_312723.1 CDS ECs4696 NC_002695.1 4732629 4734056 R similar to YIEO_ECOLI gi|1790195 (conserved in Escherichia coli K-12); transporter complement(4732629..4734056) Escherichia coli O157:H7 str. Sakai 915321 NP_312724.2 CDS ECs4697 NC_002695.1 4734079 4734771 R similar to YIEP_ECOLI gi|1790196 (conserved in Escherichia coli K-12); hypothetical protein complement(4734079..4734771) Escherichia coli O157:H7 str. Sakai 915315 NP_312725.1 CDS ECs4698 NC_002695.1 4740572 4741411 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(4740572..4741411) Escherichia coli O157:H7 str. Sakai 915303 NP_312726.1 CDS ECs4699 NC_002695.1 4741530 4741868 D similar to YIFE_ECOLI gi|2367277 (conserved in Escherichia coli K-12); hypothetical protein 4741530..4741868 Escherichia coli O157:H7 str. Sakai 915294 NP_312727.1 CDS ECs4700 NC_002695.1 4741893 4743443 R among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease complement(4741893..4743443) Escherichia coli O157:H7 str. Sakai 915293 NP_312728.1 CDS ECs4701 NC_002695.1 4743766 4743864 D similar to ILVL_ECOLI gi|1790202 (conserved in Escherichia coli K-12); ilvG operon leader peptide 4743766..4743864 Escherichia coli O157:H7 str. Sakai 915291 NP_312729.1 CDS ECs4702 NC_002695.1 4744004 4745650 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4744004..4745650 Escherichia coli O157:H7 str. Sakai 915287 NP_312730.1 CDS ilvM NC_002695.1 4745647 4745910 D similar to ILVM_ECOLI gi|1790204 (conserved in Escherichia coli K-12); acetolactate synthase 2 regulatory subunit 4745647..4745910 Escherichia coli O157:H7 str. Sakai 915285 NP_312731.1 CDS ECs4704 NC_002695.1 4745930 4746859 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4745930..4746859 Escherichia coli O157:H7 str. Sakai 915283 NP_312732.1 CDS ECs4705 NC_002695.1 4746924 4748774 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4746924..4748774 Escherichia coli O157:H7 str. Sakai 915282 NP_312733.1 CDS ECs4706 NC_002695.1 4748777 4750321 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4748777..4750321 Escherichia coli O157:H7 str. Sakai 915279 NP_312734.1 CDS ECs4707 NC_002695.1 4750373 4751266 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(4750373..4751266) Escherichia coli O157:H7 str. Sakai 915274 NP_312735.1 CDS ECs4708 NC_002695.1 4751416 4752891 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4751416..4752891 Escherichia coli O157:H7 str. Sakai 915271 NP_312736.1 CDS ECs4709 NC_002695.1 4752937 4753218 R similar to PPIC_ECOLI gi|1790211 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase C complement(4752937..4753218) Escherichia coli O157:H7 str. Sakai 915269 NP_312737.1 CDS ECs4710 NC_002695.1 4753417 4753866 R similar to YIFN_ECOLI gi|2367280, b3776_ECOLI gi|2367279; hypothetical protein complement(4753417..4753866) Escherichia coli O157:H7 str. Sakai 915266 NP_312738.1 CDS ECs4711 NC_002695.1 4754083 4756104 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4754083..4756104 Escherichia coli O157:H7 str. Sakai 915261 NP_312739.1 CDS ECs4712 NC_002695.1 4756151 4757635 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(4756151..4757635) Escherichia coli O157:H7 str. Sakai 915259 NP_312740.1 CDS ECs4713 NC_002695.1 4757771 4759036 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(4757771..4759036) Escherichia coli O157:H7 str. Sakai 915257 NP_312741.1 CDS trxA NC_002695.1 4759113 4759496 D similar to TRXA_ECOLI gi|1790215 (conserved in Escherichia coli K-12); thioredoxin 4759113..4759496 Escherichia coli O157:H7 str. Sakai 915255 NP_312742.1 CDS ECs4715 NC_002695.1 4759637 4759738 D similar to RHOL_ECOLI gi|1790216 (conserved in Escherichia coli K-12); rho operon leader peptide 4759637..4759738 Escherichia coli O157:H7 str. Sakai 915252 NP_312743.1 CDS rho NC_002695.1 4759823 4761082 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4759823..4761082 Escherichia coli O157:H7 str. Sakai 915249 NP_944573.1 CDS ECs5549 NC_002695.1 4761092 4761310 D hypothetical protein 4761092..4761310 Escherichia coli O157:H7 str. Sakai 2693761 NP_312744.1 CDS ECs4717 NC_002695.1 4761322 4762425 D similar to RFE_ECOLI gi|1790218 (conserved in Escherichia coli K-12); UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4761322..4762425 Escherichia coli O157:H7 str. Sakai 915248 NP_312745.1 CDS ECs4718 NC_002695.1 4762434 4763483 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4762434..4763483 Escherichia coli O157:H7 str. Sakai 915243 NP_312746.1 CDS ECs4719 NC_002695.1 4763497 4764669 D similar to WECB_ECOLI gi|2367283 (conserved in Escherichia coli K-12); UDP-N-acetylglucosamine 2-epimerase 4763497..4764669 Escherichia coli O157:H7 str. Sakai 915240 NP_312747.1 CDS wecC NC_002695.1 4764666 4765928 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4764666..4765928 Escherichia coli O157:H7 str. Sakai 915235 NP_312748.1 CDS ECs4721 NC_002695.1 4765928 4766995 D similar to RFFG_ECOLI gi|1790223 (conserved in Escherichia coli K-12); dTDP-glucose 4,6-dehydratase 4765928..4766995 Escherichia coli O157:H7 str. Sakai 915233 NP_312749.1 CDS ECs4722 NC_002695.1 4767014 4767895 D similar to RFFH_ECOLI gi|1790224 (conserved in Escherichia coli K-12); glucose-1-phosphate thymidylyltransferase 4767014..4767895 Escherichia coli O157:H7 str. Sakai 915232 NP_312750.1 CDS ECs4723 NC_002695.1 4768002 4768547 D similar to WECD_ECOLI gi|1790225 (conserved in Escherichia coli K-12); TDP-fucosamine acetyltransferase 4768002..4768547 Escherichia coli O157:H7 str. Sakai 915226 NP_312751.1 CDS ECs4724 NC_002695.1 4768552 4769682 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4768552..4769682 Escherichia coli O157:H7 str. Sakai 915225 NP_312752.1 CDS ECs4725 NC_002695.1 4769684 4770934 D similar to WZXE_ECOLI gi|1790227 (conserved in Escherichia coli K-12); cytochrome 4769684..4770934 Escherichia coli O157:H7 str. Sakai 915223 NP_312753.1 CDS ECs4726 NC_002695.1 4770931 4772010 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4770931..4772010 Escherichia coli O157:H7 str. Sakai 915126 NP_312754.1 CDS ECs4727 NC_002695.1 4772007 4773359 D enterobacterial common antigen polymerase; common antigen polymerase 4772007..4773359 Escherichia coli O157:H7 str. Sakai 915114 NP_312755.1 CDS ECs4728 NC_002695.1 4773362 4774102 D similar to WECG_ECOLI gi|2367289 (conserved in Escherichia coli K-12); UDP-N-acetyl-D-mannosaminuronic acid transferase 4773362..4774102 Escherichia coli O157:H7 str. Sakai 915133 NP_312756.1 CDS ECs4729 NC_002695.1 4774293 4775678 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4774293..4775678 Escherichia coli O157:H7 str. Sakai 915167 NP_312757.1 CDS ECs4730 NC_002695.1 4776589 4777824 D similar to ASLB_ECOLI gi|2367292 (conserved in Escherichia coli K-12); arylsulfatase 4776589..4777824 Escherichia coli O157:H7 str. Sakai 915197 NP_312758.1 CDS ECs4731 NC_002695.1 4777992 4779647 R similar to ASLA_ECOLI gi|1790233 (conserved in Escherichia coli K-12); arylsulfatase complement(4777992..4779647) Escherichia coli O157:H7 str. Sakai 915195 NP_312759.1 CDS ECs4732 NC_002695.1 4780326 4781522 R similar to HEMY_ECOLI gi|1790234 (conserved in Escherichia coli K-12); protoheme IX biogenesis protein complement(4780326..4781522) Escherichia coli O157:H7 str. Sakai 915180 NP_312760.1 CDS ECs4733 NC_002695.1 4781525 4782724 R similar to HEMX_ECOLI gi|1790235; uroporphyrinogen III C-methyltransferase complement(4781525..4782724) Escherichia coli O157:H7 str. Sakai 915182 NP_312761.1 CDS hemD NC_002695.1 4782746 4783486 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4782746..4783486) Escherichia coli O157:H7 str. Sakai 915187 NP_312762.1 CDS hemC NC_002695.1 4783483 4784445 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4783483..4784445) Escherichia coli O157:H7 str. Sakai 915188 NP_312763.1 CDS cyaA NC_002695.1 4784811 4787357 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4784811..4787357 Escherichia coli O157:H7 str. Sakai 915191 NP_312764.1 CDS cyaY NC_002695.1 4787397 4787717 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4787397..4787717) Escherichia coli O157:H7 str. Sakai 915190 NP_312765.1 CDS ECs4737 NC_002695.1 4787508 4787993 D similar to B3808_ECOLI gi|1790240 (conserved in Escherichia coli K-12); hypothetical protein 4787508..4787993 Escherichia coli O157:H7 str. Sakai 915189 NP_944574.1 CDS ECs5556 NC_002695.1 4788180 4788383 D hypothetical protein 4788180..4788383 Escherichia coli O157:H7 str. Sakai 2693762 NP_312766.2 CDS dapF NC_002695.1 4788420 4789244 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4788420..4789244 Escherichia coli O157:H7 str. Sakai 915186 NP_312767.1 CDS ECs4740 NC_002695.1 4789241 4789948 D similar to YIGA_ECOLI gi|1790243 (conserved in Escherichia coli K-12); hypothetical protein 4789241..4789948 Escherichia coli O157:H7 str. Sakai 915185 NP_312768.1 CDS xerC NC_002695.1 4789945 4790841 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4789945..4790841 Escherichia coli O157:H7 str. Sakai 912638 NP_312769.1 CDS ECs4742 NC_002695.1 4790841 4791557 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4790841..4791557 Escherichia coli O157:H7 str. Sakai 912640 NP_312770.1 CDS uvrD NC_002695.1 4791641 4793803 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4791641..4793803 Escherichia coli O157:H7 str. Sakai 915330 NP_312771.1 CDS ECs4744 NC_002695.1 4793848 4794750 R similar to conserved hypothetical proteins e.g. HP0709 [Helicobacter pylori 26695] gi|7463979|pir||E64608; hypothetical protein complement(4793848..4794750) Escherichia coli O157:H7 str. Sakai 915184 NP_312772.1 CDS ECs4745 NC_002695.1 4794833 4795597 R similar to YIGE_ECOLI gi|1790248, B3814_ECOLI gi|1790247; hypothetical protein complement(4794833..4795597) Escherichia coli O157:H7 str. Sakai 915183 NP_312773.1 CDS ECs4746 NC_002695.1 4795967 4796917 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4795967..4796917 Escherichia coli O157:H7 str. Sakai 915181 NP_312774.1 CDS ECs4747 NC_002695.1 4797447 4798295 R similar to hypothetical protein [Xylella fastidiosa] gi|9104946|gb|AAF82968.1|AE003869_5; hypothetical protein complement(4797447..4798295) Escherichia coli O157:H7 str. Sakai 915174 NP_312775.1 CDS ECs4748 NC_002695.1 4799255 4799554 D hypothetical protein 4799255..4799554 Escherichia coli O157:H7 str. Sakai 915352 NP_312776.1 CDS ECs4749 NC_002695.1 4799601 4800488 R similar to RARD_ECOLI gi|1790252 (conserved in Escherichia coli K-12); hypothetical protein complement(4799601..4800488) Escherichia coli O157:H7 str. Sakai 915312 NP_312777.2 CDS ECs4750 NC_002695.1 4800540 4801007 R similar to YIGI_ECOLI gi|2367298 (conserved in Escherichia coli K-12); hypothetical protein complement(4800540..4801007) Escherichia coli O157:H7 str. Sakai 915155 NP_312778.1 CDS ECs4751 NC_002695.1 4801172 4802041 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4801172..4802041 Escherichia coli O157:H7 str. Sakai 915153 NP_312779.1 CDS ECs4752 NC_002695.1 4802168 4804003 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4802168..4804003 Escherichia coli O157:H7 str. Sakai 915152 NP_312780.1 CDS ECs4753 NC_002695.1 4804067 4804687 D similar to RHTC_ECOLI gi|2851443|sp|P27846 (conserved in Escherichia coli K-12); threonine efflux system 4804067..4804687 Escherichia coli O157:H7 str. Sakai 915151 NP_312781.1 CDS rhtB NC_002695.1 4804749 4805369 R similar to RHTB_ECOLI gi|6093972|sp|P27847 (conserved in Escherichia coli K-12); homoserine/homoserine lactone efflux protein complement(4804749..4805369) Escherichia coli O157:H7 str. Sakai 915150 NP_312782.1 CDS ECs4755 NC_002695.1 4805480 4806502 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4805480..4806502 Escherichia coli O157:H7 str. Sakai 915149 NP_312783.1 CDS ECs4756 NC_002695.1 4806510 4807310 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4806510..4807310 Escherichia coli O157:H7 str. Sakai 915148 NP_312784.1 CDS ECs4757 NC_002695.1 4807386 4808285 D similar to YIGM_ECOLI gi|1790261 (conserved in Escherichia coli K-12); hypothetical protein 4807386..4808285 Escherichia coli O157:H7 str. Sakai 915147 NP_312785.1 CDS ECs4758 NC_002695.1 4808173 4809126 R similar to METR_ECOLI gi|1790262 (conserved in Escherichia coli K-12); regulator for metE and metH complement(4808173..4809126) Escherichia coli O157:H7 str. Sakai 915146 NP_312786.1 CDS ECs4759 NC_002695.1 4809362 4811623 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 4809362..4811623 Escherichia coli O157:H7 str. Sakai 915145 NP_312787.1 CDS ECs4760 NC_002695.1 4811663 4812544 R similar to YSGA_ECOLI gi|2367305; hypothetical protein complement(4811663..4812544) Escherichia coli O157:H7 str. Sakai 915144 NP_312788.1 CDS ECs4761 NC_002695.1 4812740 4813501 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4812740..4813501 Escherichia coli O157:H7 str. Sakai 915143 NP_312789.1 CDS ECs4762 NC_002695.1 4813642 4815069 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4813642..4815069 Escherichia coli O157:H7 str. Sakai 915142 NP_312790.1 CDS ubiE NC_002695.1 4815164 4815919 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4815164..4815919 Escherichia coli O157:H7 str. Sakai 915141 NP_312791.1 CDS ECs4764 NC_002695.1 4815933 4816538 D similar to YIGP_ECOLI gi|2367308 (conserved in Escherichia coli K-12); hypothetical protein 4815933..4816538 Escherichia coli O157:H7 str. Sakai 915140 NP_312792.1 CDS ubiB NC_002695.1 4816535 4818175 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4816535..4818175 Escherichia coli O157:H7 str. Sakai 915139 NP_312793.1 CDS tatA NC_002695.1 4818254 4818523 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 4818254..4818523 Escherichia coli O157:H7 str. Sakai 915138 NP_312794.1 CDS ECs4767 NC_002695.1 4818527 4819042 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4818527..4819042 Escherichia coli O157:H7 str. Sakai 915137 NP_312795.1 CDS ECs4768 NC_002695.1 4819045 4819821 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4819045..4819821 Escherichia coli O157:H7 str. Sakai 915136 NP_312796.1 CDS ECs4769 NC_002695.1 4819863 4820645 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4819863..4820645 Escherichia coli O157:H7 str. Sakai 915135 NP_312797.1 CDS rfaH NC_002695.1 4820642 4821130 R transcriptional activator; similar to RFAH_ECOLI gi|1790276 (conserved in Escherichia coli K-12); transcriptional activator RfaH complement(4820642..4821130) Escherichia coli O157:H7 str. Sakai 915134 NP_312798.1 CDS ECs4771 NC_002695.1 4821297 4822790 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4821297..4822790 Escherichia coli O157:H7 str. Sakai 915132 NP_312799.1 CDS fre NC_002695.1 4822836 4823537 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4822836..4823537 Escherichia coli O157:H7 str. Sakai 915131 NP_312800.1 CDS fadA NC_002695.1 4823729 4824892 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4823729..4824892) Escherichia coli O157:H7 str. Sakai 915130 NP_312801.1 CDS fadB NC_002695.1 4824902 4827091 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4824902..4827091) Escherichia coli O157:H7 str. Sakai 915128 NP_312802.1 CDS ECs4775 NC_002695.1 4827281 4828612 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4827281..4828612 Escherichia coli O157:H7 str. Sakai 915127 NP_312803.2 CDS ECs4776 NC_002695.1 4828612 4829226 D similar to YIGZ_ECOLI gi|1790283 (conserved in Escherichia coli K-12); hypothetical protein 4828612..4829226 Escherichia coli O157:H7 str. Sakai 916139 NP_312804.1 CDS ECs4777 NC_002695.1 4829265 4830716 D similar to TRKH_ECOLI gi|2367317, TRKH_ECOLI SW: P21166 (conserved in Escherichia coli K-12); potassium transporter 4829265..4830716 Escherichia coli O157:H7 str. Sakai 915125 NP_312805.1 CDS hemG NC_002695.1 4830728 4831273 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4830728..4831273 Escherichia coli O157:H7 str. Sakai 915124 NP_312806.1 CDS ECs4779 NC_002695.1 4836858 4837370 R in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4836858..4837370) Escherichia coli O157:H7 str. Sakai 915118 NP_312807.1 CDS mobA NC_002695.1 4837367 4837951 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(4837367..4837951) Escherichia coli O157:H7 str. Sakai 915117 NP_312808.1 CDS ECs4781 NC_002695.1 4838021 4838290 D similar to YIHD_ECOLI gi|1790289 (conserved in Escherichia coli K-12); hypothetical protein 4838021..4838290 Escherichia coli O157:H7 str. Sakai 915116 NP_312809.1 CDS ECs4782 NC_002695.1 4838367 4839353 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4838367..4839353 Escherichia coli O157:H7 str. Sakai 915109 NP_312810.1 CDS ECs4783 NC_002695.1 4839370 4839996 D similar to DSBA_ECOLI gi|1790291 (conserved in Escherichia coli K-12); protein disulfide isomerase I 4839370..4839996 Escherichia coli O157:H7 str. Sakai 915115 NP_312811.2 CDS ECs4784 NC_002695.1 4840151 4841581 D similar to YIHF_ECOLI gi|2367319 (conserved in Escherichia coli K-12); hypothetical protein 4840151..4841581 Escherichia coli O157:H7 str. Sakai 915113 NP_312812.1 CDS ECs4785 NC_002695.1 4841622 4842554 R similar to YIHG_ECOLI gi|1790293 (conserved in Escherichia coli K-12); acyltransferase complement(4841622..4842554) Escherichia coli O157:H7 str. Sakai 915112 NP_944575.1 CDS ECs5562 NC_002695.1 4842674 4842916 R hypothetical protein complement(4842674..4842916) Escherichia coli O157:H7 str. Sakai 2693763 NP_312813.1 CDS ECs4786 NC_002695.1 4842918 4845704 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4842918..4845704 Escherichia coli O157:H7 str. Sakai 915111 NP_312814.1 CDS engB NC_002695.1 4846086 4846718 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4846086..4846718) Escherichia coli O157:H7 str. Sakai 915108 NP_312815.1 CDS ECs4788 NC_002695.1 4847300 4847806 D similar to YIHI_ECOLI gi|1790297 (conserved in Escherichia coli K-12); hypothetical protein 4847300..4847806 Escherichia coli O157:H7 str. Sakai 915107 NP_312816.2 CDS ECs4789 NC_002695.1 4847995 4849368 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4847995..4849368 Escherichia coli O157:H7 str. Sakai 915106 NP_312817.1 CDS glnG NC_002695.1 4849780 4851189 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4849780..4851189) Escherichia coli O157:H7 str. Sakai 915105 NP_312818.1 CDS glnL NC_002695.1 4851201 4852250 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4851201..4852250) Escherichia coli O157:H7 str. Sakai 915104 NP_312819.1 CDS glnA NC_002695.1 4852424 4853833 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4852424..4853833) Escherichia coli O157:H7 str. Sakai 915103 NP_312820.1 CDS ECs4793 NC_002695.1 4854206 4856029 D similar to YIHK_ECOLI gi|1790302 (conserved in Escherichia coli K-12); GTP-binding protein 4854206..4856029 Escherichia coli O157:H7 str. Sakai 915102 NP_312821.1 CDS ECs4794 NC_002695.1 4856246 4856956 D similar to YIHL_ECOLI gi|1790304 (conserved in Escherichia coli K-12); transcriptional regulator 4856246..4856956 Escherichia coli O157:H7 str. Sakai 915101 NP_312822.1 CDS ECs4795 NC_002695.1 4856964 4857944 D similar to YIHM_ECOLI gi|1790305 (conserved in Escherichia coli K-12); hypothetical protein 4856964..4857944 Escherichia coli O157:H7 str. Sakai 915100 NP_312823.1 CDS ECs4796 NC_002695.1 4858046 4859311 D similar to YIHN_ECOLI gi|1790306 (conserved in Escherichia coli K-12); resistance protein 4858046..4859311 Escherichia coli O157:H7 str. Sakai 915099 NP_312824.2 CDS ompL NC_002695.1 4859402 4860094 R porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L complement(4859402..4860094) Escherichia coli O157:H7 str. Sakai 915088 NP_312825.1 CDS ECs4798 NC_002695.1 4860161 4861564 R similar to YIHO_ECOLI gi|2367321 (conserved in Escherichia coli K-12); permease complement(4860161..4861564) Escherichia coli O157:H7 str. Sakai 915093 NP_312826.1 CDS ECs4799 NC_002695.1 4861607 4862992 R similar to YIHP_ECOLI gi|2367322 (conserved in Escherichia coli K-12); permease complement(4861607..4862992) Escherichia coli O157:H7 str. Sakai 915096 NP_312827.1 CDS ECs4800 NC_002695.1 4863038 4865074 R similar to YIHQ_ECOLI gi|2367323 (conserved in Escherichia coli K-12); alpha-glucosidase complement(4863038..4865074) Escherichia coli O157:H7 str. Sakai 915098 NP_312828.1 CDS ECs4801 NC_002695.1 4865182 4866057 R similar to membrane protein [Staphylococcus aureus] gi|3676428|gb|AAC61946.1; hypothetical protein complement(4865182..4866057) Escherichia coli O157:H7 str. Sakai 915097 NP_312829.1 CDS ECs4802 NC_002695.1 4866118 4867020 R similar to YIHR_ECOLI gi|1790311 (conserved in Escherichia coli K-12); aldose-1-epimerase complement(4866118..4867020) Escherichia coli O157:H7 str. Sakai 915089 NP_312830.1 CDS ECs4803 NC_002695.1 4867087 4868328 R similar to YIHS_ECOLI gi|1790313 (conserved in Escherichia coli K-12); hypothetical protein complement(4867087..4868328) Escherichia coli O157:H7 str. Sakai 915091 NP_312831.1 CDS ECs4804 NC_002695.1 4868344 4869222 R similar to YIHT_ECOLI gi|1790314 (conserved in Escherichia coli K-12); aldolase complement(4868344..4869222) Escherichia coli O157:H7 str. Sakai 915094 NP_312832.1 CDS ECs4805 NC_002695.1 4869246 4870142 R similar to YIHU_ECOLI gi|1790315 (conserved in Escherichia coli K-12); dehydrogenase complement(4869246..4870142) Escherichia coli O157:H7 str. Sakai 915095 NP_312833.1 CDS ECs4806 NC_002695.1 4870304 4871206 D similar to YIHV_ECOLI gi|1790316 (conserved in Escherichia coli K-12); kinase 4870304..4871206 Escherichia coli O157:H7 str. Sakai 916219 NP_312834.1 CDS ECs4807 NC_002695.1 4871216 4872025 D similar to YIHW_ECOLI gi|1790317 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 4871216..4872025 Escherichia coli O157:H7 str. Sakai 915075 NP_312835.2 CDS ECs4808 NC_002695.1 4872124 4872723 D similar to YIHX_ECOLI gi|1790318 (conserved in Escherichia coli K-12); phosphatase 4872124..4872723 Escherichia coli O157:H7 str. Sakai 915090 NP_312836.1 CDS rbn NC_002695.1 4872717 4873589 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4872717..4873589 Escherichia coli O157:H7 str. Sakai 915086 NP_312837.1 CDS ECs4810 NC_002695.1 4873586 4874023 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4873586..4874023 Escherichia coli O157:H7 str. Sakai 915087 NP_312838.1 CDS ECs4811 NC_002695.1 4874020 4875009 D similar to YIID_ECOLI gi|1790321 (conserved in Escherichia coli K-12); acetyltransferase 4874020..4875009 Escherichia coli O157:H7 str. Sakai 915092 NP_312839.1 CDS ECs4812 NC_002695.1 4875420 4876313 D hypothetical protein 4875420..4876313 Escherichia coli O157:H7 str. Sakai 915081 NP_312840.1 CDS ECs4813 NC_002695.1 4876320 4877234 D hypothetical protein 4876320..4877234 Escherichia coli O157:H7 str. Sakai 915082 NP_312841.1 CDS ECs4814 NC_002695.1 4877407 4877625 R hypothetical protein complement(4877407..4877625) Escherichia coli O157:H7 str. Sakai 915083 NP_312842.1 CDS ECs4815 NC_002695.1 4877901 4878146 D similar to YIIE_ECOLI gi|1790322 (conserved in Escherichia coli K-12); hypothetical protein 4877901..4878146 Escherichia coli O157:H7 str. Sakai 915084 NP_312843.1 CDS ECs4816 NC_002695.1 4878363 4878605 D similar to YIIF_ECOLI gi|1790323 (conserved in Escherichia coli K-12); hypothetical protein 4878363..4878605 Escherichia coli O157:H7 str. Sakai 915076 NP_312844.1 CDS ECs4817 NC_002695.1 4878935 4879864 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4878935..4879864) Escherichia coli O157:H7 str. Sakai 915077 NP_312845.1 CDS ECs4818 NC_002695.1 4879861 4880496 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4879861..4880496) Escherichia coli O157:H7 str. Sakai 915078 NP_312846.1 CDS ECs4819 NC_002695.1 4880493 4881395 R similar to FDOH_ECOLI gi|1790326 (conserved in Escherichia coli K-12); formate dehydrogenase-O iron-sulfur subunit complement(4880493..4881395) Escherichia coli O157:H7 str. Sakai 915080 NP_312847.1 CDS ECs4820 NC_002695.1 4881408 4884458 R similar to FDOG_ECOLI gi|3868719 (conserved in Escherichia coli K-12); formate dehydrogenase-O major subunit complement(4881408..4884458) Escherichia coli O157:H7 str. Sakai 915079 NP_312848.1 CDS ECs4821 NC_002695.1 4884652 4885485 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4884652..4885485 Escherichia coli O157:H7 str. Sakai 915071 NP_312849.1 CDS ECs4822 NC_002695.1 4885638 4886693 D similar to YIIG_ECOLI gi|1790330 (conserved in Escherichia coli K-12); hypothetical protein 4885638..4886693 Escherichia coli O157:H7 str. Sakai 915072 NP_312850.1 CDS ECs4823 NC_002695.1 4886743 4888491 R repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein complement(4886743..4888491) Escherichia coli O157:H7 str. Sakai 915073 NP_312851.1 CDS ECs4824 NC_002695.1 4888491 4889561 R with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX complement(4888491..4889561) Escherichia coli O157:H7 str. Sakai 915074 NP_312852.1 CDS ECs4825 NC_002695.1 4889551 4890990 R similar to PTVB_ECOLI gi|1790333 (conserved in Escherichia coli K-12); PTS system transporter subunits IIBC complement(4889551..4890990) Escherichia coli O157:H7 str. Sakai 915066 NP_312853.1 CDS ECs4826 NC_002695.1 4891001 4891447 R with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA complement(4891001..4891447) Escherichia coli O157:H7 str. Sakai 915068 NP_312854.1 CDS ECs4827 NC_002695.1 4891925 4893319 D similar to RafY [Escherichia coli plasmid pRSD2] gi|1773072|gb|AAB71432.1; glycoprotein 4891925..4893319 Escherichia coli O157:H7 str. Sakai 915069 NP_312855.1 CDS ECs4828 NC_002695.1 4893360 4893674 R similar to YIIL_ECOLI gi|1790335 (conserved in Escherichia coli K-12); hypothetical protein complement(4893360..4893674) Escherichia coli O157:H7 str. Sakai 915070 NP_312856.1 CDS ECs4829 NC_002695.1 4893684 4894508 R similar to RHAD_ECOLI gi|1790336 (conserved in Escherichia coli K-12); rhamnulose-1-phosphate aldolase complement(4893684..4894508) Escherichia coli O157:H7 str. Sakai 915067 NP_312857.1 CDS ECs4830 NC_002695.1 4894683 4895942 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4894683..4895942) Escherichia coli O157:H7 str. Sakai 915061 NP_312858.1 CDS rhaB NC_002695.1 4895939 4897408 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4895939..4897408) Escherichia coli O157:H7 str. Sakai 915063 NP_312859.1 CDS ECs4832 NC_002695.1 4897696 4898532 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4897696..4898532 Escherichia coli O157:H7 str. Sakai 915064 NP_312860.1 CDS ECs4833 NC_002695.1 4898516 4899454 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4898516..4899454 Escherichia coli O157:H7 str. Sakai 915065 NP_312861.2 CDS ECs4834 NC_002695.1 4900764 4901390 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4900764..4901390 Escherichia coli O157:H7 str. Sakai 916147 NP_312862.2 CDS ECs4835 NC_002695.1 4901650 4902633 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4901650..4902633 Escherichia coli O157:H7 str. Sakai 914956 NP_312863.2 CDS ECs4836 NC_002695.1 4902782 4903456 D similar to YIIM_ECOLI gi|1790345 (conserved in Escherichia coli K-12); hypothetical protein 4902782..4903456 Escherichia coli O157:H7 str. Sakai 915037 NP_312864.1 CDS cpxA NC_002695.1 4903562 4904935 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4903562..4904935) Escherichia coli O157:H7 str. Sakai 914983 NP_312865.1 CDS ECs4838 NC_002695.1 4904932 4905630 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; CpxR family transcriptional regulator complement(4904932..4905630) Escherichia coli O157:H7 str. Sakai 915041 NP_312866.2 CDS cpxP NC_002695.1 4905780 4906280 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4905780..4906280 Escherichia coli O157:H7 str. Sakai 915059 NP_312867.1 CDS fieF NC_002695.1 4906429 4907331 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4906429..4907331 Escherichia coli O157:H7 str. Sakai 915062 NP_312868.1 CDS pfkA NC_002695.1 4907512 4908474 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4907512..4908474 Escherichia coli O157:H7 str. Sakai 915060 NP_944576.1 CDS ECs5564 NC_002695.1 4908583 4908765 R hypothetical protein complement(4908583..4908765) Escherichia coli O157:H7 str. Sakai 2693828 NP_312869.1 CDS ECs4842 NC_002695.1 4908793 4909782 D similar to SBP_ECOLI gi|1790351 (conserved in Escherichia coli K-12); sulfate transporter subunit 4908793..4909782 Escherichia coli O157:H7 str. Sakai 915053 NP_312870.1 CDS ECs4843 NC_002695.1 4909889 4910644 D similar to CDH_ECOLI gi|1790352 (conserved in Escherichia coli K-12); CDP-diacylglycerol pyrophosphatase 4909889..4910644 Escherichia coli O157:H7 str. Sakai 915054 NP_312871.1 CDS tpiA NC_002695.1 4910699 4911466 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4910699..4911466) Escherichia coli O157:H7 str. Sakai 915057 NP_312872.1 CDS ECs4845 NC_002695.1 4911574 4912173 R similar to YIIQ_ECOLI gi|1790354 (conserved in Escherichia coli K-12); hypothetical protein complement(4911574..4912173) Escherichia coli O157:H7 str. Sakai 915058 NP_312873.1 CDS ECs4846 NC_002695.1 4912274 4912714 D similar to YIIR_ECOLI gi|1790355 (conserved in Escherichia coli K-12); hypothetical protein 4912274..4912714 Escherichia coli O157:H7 str. Sakai 915056 NP_312874.1 CDS ECs4847 NC_002695.1 4912926 4913225 D similar to YIIS_ECOLI gi|1790357 (conserved in Escherichia coli K-12); hypothetical protein 4912926..4913225 Escherichia coli O157:H7 str. Sakai 915047 NP_312875.1 CDS ECs4848 NC_002695.1 4913252 4913680 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4913252..4913680 Escherichia coli O157:H7 str. Sakai 915045 NP_312876.1 CDS ECs4849 NC_002695.1 4913685 4914431 R similar to FPR_ECOLI gi|1790359 (conserved in Escherichia coli K-12); ferredoxin-NADP reductase complement(4913685..4914431) Escherichia coli O157:H7 str. Sakai 915048 NP_312877.1 CDS glpX NC_002695.1 4914528 4915538 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4914528..4915538) Escherichia coli O157:H7 str. Sakai 915049 NP_312878.1 CDS glpK NC_002695.1 4915768 4917276 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4915768..4917276) Escherichia coli O157:H7 str. Sakai 915050 NP_312879.1 CDS ECs4852 NC_002695.1 4917299 4918144 R similar to GLPF_ECOLI gi|1790362 (conserved in Escherichia coli K-12); glycerol facilitator protein complement(4917299..4918144) Escherichia coli O157:H7 str. Sakai 915039 NP_312880.2 CDS ECs4853 NC_002695.1 4918576 4918815 D similar to YIIU_ECOLI gi|1790363 (conserved in Escherichia coli K-12); hypothetical protein 4918576..4918815 Escherichia coli O157:H7 str. Sakai 915040 NP_312881.1 CDS ECs4854 NC_002695.1 4918854 4919570 R hypothetical protein complement(4918854..4919570) Escherichia coli O157:H7 str. Sakai 915043 NP_312882.1 CDS ECs4855 NC_002695.1 4919603 4920277 R hypothetical protein complement(4919603..4920277) Escherichia coli O157:H7 str. Sakai 915044 NP_312883.1 CDS ECs4856 NC_002695.1 4920337 4920822 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4920337..4920822) Escherichia coli O157:H7 str. Sakai 915029 NP_312884.1 CDS ECs4857 NC_002695.1 4920915 4921841 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4920915..4921841) Escherichia coli O157:H7 str. Sakai 915030 NP_312885.1 CDS hslU NC_002695.1 4921908 4923239 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding protein HslU complement(4921908..4923239) Escherichia coli O157:H7 str. Sakai 915031 NP_312886.1 CDS ECs4859 NC_002695.1 4923249 4923779 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4923249..4923779) Escherichia coli O157:H7 str. Sakai 915032 NP_312887.1 CDS ECs4860 NC_002695.1 4923872 4924831 R similar to FTSN_ECOLI gi|1790368 (conserved in Escherichia coli K-12); cell division protein FtsN complement(4923872..4924831) Escherichia coli O157:H7 str. Sakai 915034 NP_312888.1 CDS ECs4861 NC_002695.1 4924923 4925948 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4924923..4925948) Escherichia coli O157:H7 str. Sakai 915035 NP_312889.1 CDS ECs4862 NC_002695.1 4926104 4928302 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4926104..4928302) Escherichia coli O157:H7 str. Sakai 915025 NP_312890.1 CDS rpmE NC_002695.1 4928505 4928717 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4928505..4928717 Escherichia coli O157:H7 str. Sakai 915027 NP_312891.1 CDS ECs4864 NC_002695.1 4928877 4933061 D RhsH core protein with extension; similar to Rhs proteins e.g. RhsF [Escherichia coli] gi|2920637|gb|AAC32473.1|; protein RhsH 4928877..4933061 Escherichia coli O157:H7 str. Sakai 915028 NP_944577.1 CDS ECs5565 NC_002695.1 4933352 4933630 D hypothetical protein 4933352..4933630 Escherichia coli O157:H7 str. Sakai 2693829 NP_312892.1 CDS ECs4865 NC_002695.1 4934070 4934363 D hypothetical protein 4934070..4934363 Escherichia coli O157:H7 str. Sakai 915022 NP_312893.1 CDS ECs4866 NC_002695.1 4934292 4934900 R member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase complement(4934292..4934900) Escherichia coli O157:H7 str. Sakai 915023 NP_312894.1 CDS ECs4867 NC_002695.1 4934960 4935277 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(4934960..4935277) Escherichia coli O157:H7 str. Sakai 915024 NP_312895.1 CDS ECs4868 NC_002695.1 4935554 4936714 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4935554..4936714 Escherichia coli O157:H7 str. Sakai 915015 NP_312896.1 CDS metL NC_002695.1 4936717 4939149 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4936717..4939149 Escherichia coli O157:H7 str. Sakai 915016 NP_312897.1 CDS metF NC_002695.1 4939498 4940388 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4939498..4940388 Escherichia coli O157:H7 str. Sakai 915018 NP_312898.1 CDS ECs4871 NC_002695.1 4940717 4942897 D similar to KATG_ECOLI gi|1790378 (conserved in Escherichia coli K-12); hydroperoxidase HPI(I) 4940717..4942897 Escherichia coli O157:H7 str. Sakai 915019 NP_312899.2 CDS ECs4872 NC_002695.1 4942991 4943896 D similar to YIJE_ECOLI gi|1790379 (conserved in Escherichia coli K-12); hypothetical protein 4942991..4943896 Escherichia coli O157:H7 str. Sakai 915008 NP_312900.1 CDS ECs4873 NC_002695.1 4943923 4944540 R similar to YIJF_ECOLI gi|1790380 (conserved in Escherichia coli K-12); hypothetical protein complement(4943923..4944540) Escherichia coli O157:H7 str. Sakai 915009 NP_312901.2 CDS gldA NC_002695.1 4944814 4945917 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(4944814..4945917) Escherichia coli O157:H7 str. Sakai 915010 NP_312902.1 CDS ECs4875 NC_002695.1 4945928 4946590 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(4945928..4946590) Escherichia coli O157:H7 str. Sakai 915012 NP_312903.2 CDS ECs4877 NC_002695.1 4946602 4949103 R similar to PTSA_ECOLI gi|1790383 (conserved in Escherichia coli K-12); PEP-protein phosphotransferase system enzyme I complement(4946602..4949103) Escherichia coli O157:H7 str. Sakai 915013 NP_312904.1 CDS ECs4876 NC_002695.1 4948712 4949203 D similar to YIJI_ECOLI gi|1790384; hypothetical protein 4948712..4949203 Escherichia coli O157:H7 str. Sakai 915003 NP_312906.1 CDS ECs4879 NC_002695.1 4950506 4950826 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 4950506..4950826 Escherichia coli O157:H7 str. Sakai 915006 NP_312907.1 CDS pflD NC_002695.1 4950877 4953174 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4950877..4953174 Escherichia coli O157:H7 str. Sakai 915007 NP_312908.2 CDS ECs4881 NC_002695.1 4953179 4954018 D similar to PFLC_ECOLI gi|1790389 (conserved in Escherichia coli K-12); pyruvate formate lyase II activase 4953179..4954018 Escherichia coli O157:H7 str. Sakai 914995 NP_312909.1 CDS ECs4882 NC_002695.1 4954020 4954361 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4954020..4954361 Escherichia coli O157:H7 str. Sakai 914996 NP_312910.1 CDS ECs4883 NC_002695.1 4954348 4955199 R similar to YIJO_ECOLI gi|1790391 (conserved in Escherichia coli K-12); AraC family transcriptional regulator complement(4954348..4955199) Escherichia coli O157:H7 str. Sakai 914997 NP_312911.1 CDS ECs4884 NC_002695.1 4955414 4957147 R similar to YIJP_ECOLI gi|4741821|gb|AAD28716.1|AF112861_1 (conserved in Escherichia coli K-12); hypothetical protein complement(4955414..4957147) Escherichia coli O157:H7 str. Sakai 915000 NP_312912.1 CDS ECs4885 NC_002695.1 4957330 4959981 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(4957330..4959981) Escherichia coli O157:H7 str. Sakai 915001 NP_312913.1 CDS ECs4886 NC_002695.1 4960333 4961484 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(4960333..4961484) Escherichia coli O157:H7 str. Sakai 914989 NP_312914.1 CDS argC NC_002695.1 4961638 4962642 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4961638..4962642 Escherichia coli O157:H7 str. Sakai 914990 NP_312915.2 CDS ECs4888 NC_002695.1 4962653 4963426 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4962653..4963426 Escherichia coli O157:H7 str. Sakai 914992 NP_312916.1 CDS ECs4889 NC_002695.1 4963487 4964860 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4963487..4964860 Escherichia coli O157:H7 str. Sakai 914993 NP_312917.1 CDS ECs4890 NC_002695.1 4965127 4966044 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4965127..4966044 Escherichia coli O157:H7 str. Sakai 914984 NP_312918.2 CDS ECs4891 NC_002695.1 4966027 4967427 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(4966027..4967427) Escherichia coli O157:H7 str. Sakai 914986 NP_312919.1 CDS ECs4892 NC_002695.1 4967757 4968923 D similar to amino acid amidohydrolases e.g. benzoylglycine amidohydrolase (Hippuricase) [Campylobacter jejuni] gi|1170277|spP45493|HIPO_CAMJE; amino acid amidohydrolase 4967757..4968923 Escherichia coli O157:H7 str. Sakai 914987 NP_312920.1 CDS ECs4893 NC_002695.1 4968966 4970282 D similar to membrane transport proteins e.g. citrate-proton symporter [Klebsiella pneumoniae] gi|116482|sp|P16482|CIT1_KLEPN; membrane transport/symporter protein 4968966..4970282 Escherichia coli O157:H7 str. Sakai 914976 NP_312921.1 CDS ECs4894 NC_002695.1 4970332 4971036 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4970332..4971036 Escherichia coli O157:H7 str. Sakai 914977 NP_312922.1 CDS ECs4895 NC_002695.1 4971036 4971395 D similar to YIJD_ECOLI gi|1790402 (conserved in Escherichia coli K-12); hypothetical protein 4971036..4971395 Escherichia coli O157:H7 str. Sakai 914979 NP_312923.1 CDS ECs4896 NC_002695.1 4971435 4972535 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(4971435..4972535) Escherichia coli O157:H7 str. Sakai 914980 NP_312924.1 CDS btuB NC_002695.1 4972904 4974748 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4972904..4974748 Escherichia coli O157:H7 str. Sakai 914972 NP_312925.2 CDS ECs4898 NC_002695.1 4974693 4975550 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4974693..4975550 Escherichia coli O157:H7 str. Sakai 914973 NP_312926.1 CDS murB NC_002695.1 4981074 4982102 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4981074..4982102 Escherichia coli O157:H7 str. Sakai 914964 NP_312927.1 CDS birA NC_002695.1 4982099 4983064 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4982099..4983064 Escherichia coli O157:H7 str. Sakai 914965 NP_312928.1 CDS ECs4901 NC_002695.1 4983093 4984043 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4983093..4984043) Escherichia coli O157:H7 str. Sakai 914967 NP_312929.1 CDS ECs4902 NC_002695.1 4984230 4984385 R similar to B3975_ECOLI gi|1790411; hypothetical protein complement(4984230..4984385) Escherichia coli O157:H7 str. Sakai 914968 NP_312930.1 CDS tuf NC_002695.1 4984961 4986145 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4984961..4986145 Escherichia coli O157:H7 str. Sakai 914959 NP_312931.1 CDS secE NC_002695.1 4986375 4986758 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4986375..4986758 Escherichia coli O157:H7 str. Sakai 914948 NP_312932.1 CDS nusG NC_002695.1 4986760 4987305 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4986760..4987305 Escherichia coli O157:H7 str. Sakai 914947 NP_312933.1 CDS rplK NC_002695.1 4987464 4987892 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4987464..4987892 Escherichia coli O157:H7 str. Sakai 914950 NP_312934.1 CDS rplA NC_002695.1 4987896 4988600 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4987896..4988600 Escherichia coli O157:H7 str. Sakai 914949 NP_312935.1 CDS rplJ NC_002695.1 4988892 4989389 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4988892..4989389 Escherichia coli O157:H7 str. Sakai 914951 NP_312936.1 CDS rplL NC_002695.1 4989456 4989821 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4989456..4989821 Escherichia coli O157:H7 str. Sakai 914954 NP_312937.1 CDS rpoB NC_002695.1 4990141 4994169 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4990141..4994169 Escherichia coli O157:H7 str. Sakai 914942 NP_312938.1 CDS ECs4911 NC_002695.1 4994246 4998469 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4994246..4998469 Escherichia coli O157:H7 str. Sakai 914941 NP_312939.1 CDS ECs4912 NC_002695.1 4998682 4999125 D heat shock protein; similar to HTRC_ECOLI gi|1790422; protein HtrC 4998682..4999125 Escherichia coli O157:H7 str. Sakai 914944 NP_312940.1 CDS thiH NC_002695.1 4999560 5000693 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4999560..5000693) Escherichia coli O157:H7 str. Sakai 914943 NP_312941.2 CDS thiG NC_002695.1 5000690 5001460 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(5000690..5001460) Escherichia coli O157:H7 str. Sakai 914945 NP_944578.1 CDS ECs5575 NC_002695.1 5001462 5001662 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(5001462..5001662) Escherichia coli O157:H7 str. Sakai 2693800 NP_312942.2 CDS thiF NC_002695.1 5001646 5002401 R catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF complement(5001646..5002401) Escherichia coli O157:H7 str. Sakai 914934 NP_312943.1 CDS thiE NC_002695.1 5002394 5003029 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(5002394..5003029) Escherichia coli O157:H7 str. Sakai 914936 NP_312944.1 CDS thiC NC_002695.1 5003029 5004924 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(5003029..5004924) Escherichia coli O157:H7 str. Sakai 914937 NP_312945.1 CDS ECs4918 NC_002695.1 5005157 5005633 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(5005157..5005633) Escherichia coli O157:H7 str. Sakai 914938 NP_312946.1 CDS nudC NC_002695.1 5005728 5006501 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 5005728..5006501 Escherichia coli O157:H7 str. Sakai 914939 NP_312947.1 CDS hemE NC_002695.1 5006541 5007605 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 5006541..5007605 Escherichia coli O157:H7 str. Sakai 914940 NP_312948.1 CDS ECs4921 NC_002695.1 5007615 5008286 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 5007615..5008286 Escherichia coli O157:H7 str. Sakai 914931 NP_312949.1 CDS ECs4922 NC_002695.1 5008329 5008919 D similar to YJAG_ECOLI gi|1790432 (conserved in Escherichia coli K-12); hypothetical protein 5008329..5008919 Escherichia coli O157:H7 str. Sakai 914932 NP_312950.1 CDS ECs4923 NC_002695.1 5009106 5009378 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 5009106..5009378 Escherichia coli O157:H7 str. Sakai 914933 NP_312951.1 CDS ECs4924 NC_002695.1 5009391 5010086 D similar to YJAH_ECOLI gi|1790434 (conserved in Escherichia coli K-12); hypothetical protein 5009391..5010086 Escherichia coli O157:H7 str. Sakai 914935 NP_312952.2 CDS zraP NC_002695.1 5010088 5010513 R similar to YJAI_ECOLI gi|1790435 (conserved in Escherichia coli K-12); zinc resistance protein complement(5010088..5010513) Escherichia coli O157:H7 str. Sakai 915713 NP_312953.1 CDS ECs4926 NC_002695.1 5010751 5012127 D sensor kinase; similar to HYDH_ECOLI gi|1790436 (conserved in Escherichia coli K-12); sensor protein ZraS 5010751..5012127 Escherichia coli O157:H7 str. Sakai 916224 NP_312954.1 CDS ECs4927 NC_002695.1 5012124 5013449 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 5012124..5013449 Escherichia coli O157:H7 str. Sakai 916250 NP_312955.1 CDS ECs4928 NC_002695.1 5013446 5014735 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(5013446..5014735) Escherichia coli O157:H7 str. Sakai 914922 NP_312956.1 CDS purH NC_002695.1 5014747 5016336 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(5014747..5016336) Escherichia coli O157:H7 str. Sakai 914853 NP_312957.1 CDS ECs4930 NC_002695.1 5022080 5022523 R similar to YJAB_ECOLI gi|1790442 (conserved in Escherichia coli K-12); hypothetical protein complement(5022080..5022523) Escherichia coli O157:H7 str. Sakai 916435 NP_312958.1 CDS ECs4931 NC_002695.1 5022680 5023609 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 5022680..5023609 Escherichia coli O157:H7 str. Sakai 914846 NP_312959.1 CDS ECs4932 NC_002695.1 5023878 5025479 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 5023878..5025479 Escherichia coli O157:H7 str. Sakai 914847 NP_312960.1 CDS ECs4933 NC_002695.1 5025509 5026813 D Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 5025509..5026813 Escherichia coli O157:H7 str. Sakai 914848 NP_312961.1 CDS aceK NC_002695.1 5026997 5028733 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 5026997..5028733 Escherichia coli O157:H7 str. Sakai 914849 NP_312962.1 CDS ECs4935 NC_002695.1 5028702 5030888 R similar to ARP_ECOLI gi|1790447 (conserved in Escherichia coli K-12); regulator of acetyl CoA synthetase complement(5028702..5030888) Escherichia coli O157:H7 str. Sakai 914850 NP_312963.2 CDS ECs4936 NC_002695.1 5031205 5032029 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator complement(5031205..5032029) Escherichia coli O157:H7 str. Sakai 914851 NP_312964.1 CDS metH NC_002695.1 5032229 5035912 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 5032229..5035912 Escherichia coli O157:H7 str. Sakai 914852 NP_312965.1 CDS ECs4938 NC_002695.1 5036132 5037763 D similar to YJBB_ECOLI gi|1790451 (conserved in Escherichia coli K-12); hypothetical protein 5036132..5037763 Escherichia coli O157:H7 str. Sakai 914841 NP_312966.1 CDS ECs4939 NC_002695.1 5037854 5038543 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(5037854..5038543) Escherichia coli O157:H7 str. Sakai 914842 NP_312967.1 CDS ECs4940 NC_002695.1 5038651 5038806 D similar to hypothetical protein b3122 [Escherichia coli (strain K-12)] gi|7466507|pir||G65101; hypothetical protein 5038651..5038806 Escherichia coli O157:H7 str. Sakai 914843 NP_312968.1 CDS ECs4941 NC_002695.1 5038926 5040155 R similar to L-sorbose 1-phosphate dehydrogenases, e.g. [Klebsiella pneumoniae] gi|586014|sp|P37084|SORE_KLEPN; L-sorbose 1-phosphate dehydrogenase complement(5038926..5040155) Escherichia coli O157:H7 str. Sakai 914844 NP_312970.1 CDS ECs4943 NC_002695.1 5041093 5041623 R repressor; similar to hypothetical protein HI1476 [Haemophilus influenzae] gi|1175815|sp|P44207|YE76_HAEIN, probable repressor protein [Bacteriophage D1]; regulatory protein complement(5041093..5041623) Escherichia coli O157:H7 str. Sakai 914837 NP_312971.1 CDS ECs4944 NC_002695.1 5041814 5042062 D similar to Ner-like DNA-binding proteins e.g. gi|6900348|emb|CAB71960.1|; DNA-binding protein 5041814..5042062 Escherichia coli O157:H7 str. Sakai 914838 NP_312972.1 CDS ECs4945 NC_002695.1 5042064 5044154 D similar to transposases e.g. [Neisseria meningitidis] gi|7379960|emb|CAB84536.1|; phage transposase 5042064..5044154 Escherichia coli O157:H7 str. Sakai 914839 NP_312973.1 CDS ECs4946 NC_002695.1 5044225 5045157 D similar to DNA transposition protein B [Bacteriophage Mu] gi|139318|sp|P03763|VPB_BPMU; DNA transposition protein 5044225..5045157 Escherichia coli O157:H7 str. Sakai 914840 NP_312974.1 CDS ECs4947 NC_002695.1 5045160 5045381 D similar to phosphoserine phosphatase [Neisseria meningitidis MC58] gi|7226221|gb|AAF41385.1|; hypothetical protein 5045160..5045381 Escherichia coli O157:H7 str. Sakai 914833 NP_312975.1 CDS ECs4948 NC_002695.1 5045394 5045648 D hypothetical protein 5045394..5045648 Escherichia coli O157:H7 str. Sakai 914834 NP_312976.1 CDS ECs4949 NC_002695.1 5045650 5045931 D hypothetical protein 5045650..5045931 Escherichia coli O157:H7 str. Sakai 914835 NP_312977.1 CDS ECs4950 NC_002695.1 5045928 5046200 D hypothetical protein 5045928..5046200 Escherichia coli O157:H7 str. Sakai 914836 NP_312978.1 CDS ECs4951 NC_002695.1 5046205 5046498 D hypothetical protein 5046205..5046498 Escherichia coli O157:H7 str. Sakai 914827 NP_312979.1 CDS ECs4952 NC_002695.1 5046510 5047040 D similar to host-nuclease inhibitor proteins (Gam) e.g. [Bacteriophage Mu] gi|138127|sp|P06023|VGAM_BPMU; host-nuclease inhibitor protein 5046510..5047040 Escherichia coli O157:H7 str. Sakai 914828 NP_312980.1 CDS ECs4953 NC_002695.1 5047138 5047680 D hypothetical protein 5047138..5047680 Escherichia coli O157:H7 str. Sakai 914830 NP_312981.1 CDS ECs4954 NC_002695.1 5047684 5048217 D similar to Gp11 [Bacteriophage Mu] gi|6010385|gb|AAF01088.1|AF083977_7; hypothetical protein 5047684..5048217 Escherichia coli O157:H7 str. Sakai 914831 NP_312982.1 CDS ECs4955 NC_002695.1 5048217 5048732 D similar to gp12 [Bacteriophage Mu] gi|215568|gb|AAA32400.1|; hypothetical protein 5048217..5048732 Escherichia coli O157:H7 str. Sakai 914832 NP_312983.1 CDS ECs4956 NC_002695.1 5048997 5049287 D similar to gp9 [Bacteriophage Mu] gi|6010430|gb|AAF01133.1|AF083977_54; hypothetical protein 5048997..5049287 Escherichia coli O157:H7 str. Sakai 914821 NP_944579.1 CDS ECs5580 NC_002695.1 5049284 5049469 D hypothetical protein 5049284..5049469 Escherichia coli O157:H7 str. Sakai 2693801 NP_312984.1 CDS ECs4957 NC_002695.1 5049466 5049840 D hypothetical protein 5049466..5049840 Escherichia coli O157:H7 str. Sakai 914823 NP_312985.1 CDS ECs4958 NC_002695.1 5049833 5050030 D similar to zinc finger proteins e.g. [Rattus norvegicus] gi|141712|sp|P18745|ZO22_XENLA; hypothetical protein 5049833..5050030 Escherichia coli O157:H7 str. Sakai 914825 NP_312986.1 CDS ECs4959 NC_002695.1 5050020 5050316 D hypothetical protein 5050020..5050316 Escherichia coli O157:H7 str. Sakai 914826 NP_312987.1 CDS ECs4960 NC_002695.1 5050313 5050822 D similar to hypothetical proteins e.g. gp16 [Bacteriophage Mu] gi|6010390|gb|AAF01093.1|AF083977_12; hypothetical protein 5050313..5050822 Escherichia coli O157:H7 str. Sakai 914329 NP_312988.1 CDS ECs4961 NC_002695.1 5050892 5051317 D probable positive regulator of late transcription; similar to transcription regulators e.g. positive regulator of late transcription (protein C) [Bacteriophage Mu] gi|139320|sp|P06022|VPC_BPMU; transcriptional regulator 5050892..5051317 Escherichia coli O157:H7 str. Sakai 914606 NP_312989.1 CDS ECs4962 NC_002695.1 5051389 5051889 D endolysin (host cell lysis); similar to endolysins e.g. Lys [Bacteriophage Mu] |126600|sp|P27359|LYCV_BPP21; endolysin 5051389..5051889 Escherichia coli O157:H7 str. Sakai 914735 NP_312991.1 CDS ECs4964 NC_002695.1 5052108 5052554 D similar to P16 [Bacteriophage APSE-1] gi|6118011|gb|AAF03959.1|AF157835_16; hypothetical protein 5052108..5052554 Escherichia coli O157:H7 str. Sakai 914994 NP_312992.1 CDS ECs4965 NC_002695.1 5052564 5052791 D similar to traR family, e.g. Orf82 [Bacteriophage P2] gi|732223|sp|Q06424|YO82_BPP2; C4-type zinc finger TraR 5052564..5052791 Escherichia coli O157:H7 str. Sakai 914966 NP_312993.1 CDS ECs4966 NC_002695.1 5052772 5053080 D similar to gp25 [Bacteriophage Mu] gi|6010400|gb|AAF01103.1|AF083977_22; hypothetical protein 5052772..5053080 Escherichia coli O157:H7 str. Sakai 914969 NP_312994.1 CDS ECs4967 NC_002695.1 5053077 5053367 D similar to hypothetical proteins e.g. gp26 [Bacteriophage Mu] gi|6010401|gb|AAF01104.1|AF083977_23; hypothetical protein 5053077..5053367 Escherichia coli O157:H7 str. Sakai 914988 NP_312995.1 CDS ECs4968 NC_002695.1 5053370 5053951 D similar to hypothetical proteins e.g. gp27 [Bacteriophage Mu] gi|6010402|gb|AAF01105.1|AF083977_24; hypothetical protein 5053370..5053951 Escherichia coli O157:H7 str. Sakai 914975 NP_312996.1 CDS ECs4969 NC_002695.1 5053951 5055615 D similar to hypothetical proteins e.g. gp28 (possible portal protein H) [Bacteriophage Mu] gi|6010403|gb|AAF01106.1|AF083977_25; portal protein 5053951..5055615 Escherichia coli O157:H7 str. Sakai 914978 NP_312997.1 CDS ECs4970 NC_002695.1 5055678 5057204 D similar to hypothetical proteins e.g. gp29 [Bacteriophage Mu] gi|6010404|gb|AAF01107.1|AF083977_26; hypothetical protein 5055678..5057204 Escherichia coli O157:H7 str. Sakai 914981 NP_312998.1 CDS ECs4971 NC_002695.1 5057188 5058513 D similar to hypothetical proteins e.g. gp30 [Bacteriophage Mu] gi|6010405|gb|AAF01108.1|AF083977_27; hypothetical protein 5057188..5058513 Escherichia coli O157:H7 str. Sakai 914985 NP_312999.1 CDS ECs4972 NC_002695.1 5058632 5059105 D similar to G protein [Bacteriophage Mu] gi|267389|sp|Q01261|VPG_BPMU; virion morphogenesis protein 5058632..5059105 Escherichia coli O157:H7 str. Sakai 914960 NP_313000.1 CDS ECs4973 NC_002695.1 5059282 5060406 D similar to gpI [Bacteriophage Mu] gi|7226336|gb|AAF41489.1|; contains potential internal start site for homologue of p20 (Z)- the postulated scaffold protein; protease 5059282..5060406 Escherichia coli O157:H7 str. Sakai 914962 NP_313001.1 CDS ECs4974 NC_002695.1 5060406 5061353 D similar to protein T [Bacteriophage Mu] gi|6010409|gb|AAF01112.1|AF083977_31, hypothetical proteins e.g. [Neisseria meningitidis] gi|6900377|emb|CAB71989.1|; major head subunit 5060406..5061353 Escherichia coli O157:H7 str. Sakai 914958 NP_313002.1 CDS ECs4975 NC_002695.1 5061397 5061783 D similar to gp35 [Bacteriophage Mu] gi|6010410|gb|AAF01113.1|AF083977_32; hypothetical protein 5061397..5061783 Escherichia coli O157:H7 str. Sakai 915717 NP_313003.1 CDS ECs4976 NC_002695.1 5061780 5062199 D similar to hypothetical proteins e.g. gp36 [Bacteriophage Mu] gi|6010411|gb|AAF01114.1|AF083977_33; hypothetical protein 5061780..5062199 Escherichia coli O157:H7 str. Sakai 915728 NP_313004.1 CDS ECs4977 NC_002695.1 5062196 5062756 D similar to hypothetical proteins e.g. gp37 [Bacteriophage Mu] gi|1175870|sp|P44231|YF09_HAEIN; hypothetical protein 5062196..5062756 Escherichia coli O157:H7 str. Sakai 914946 NP_313005.1 CDS ECs4978 NC_002695.1 5062757 5063002 D similar to hypothetical proteins e.g. gp38 [Bacteriophage Mu] gi|6010413|gb|AAF01116.1|AF083977_35; hypothetical protein 5062757..5063002 Escherichia coli O157:H7 str. Sakai 914952 NP_313006.1 CDS ECs4979 NC_002695.1 5062999 5064501 D similar to sheath protein GpL [Bacteriophage Mu] gi|1834291|dbj|BAA19195.1|, hypothetical proteins e.g. [Haemophilus influenzae Rd] gi|1175872|sp|P44233|YF11_HAEIN; tail sheath protein 5062999..5064501 Escherichia coli O157:H7 str. Sakai 914953 NP_313007.1 CDS ECs4980 NC_002695.1 5064510 5064875 D similar to hypothetical proteins e.g. GpM [Bacteriophage Mu] gi|1834292|dbj|BAA19196.1|; hypothetical protein 5064510..5064875 Escherichia coli O157:H7 str. Sakai 914998 NP_313008.1 CDS ECs4981 NC_002695.1 5064890 5065366 D similar to hypothetical proteins e.g. ORF3 [Bacteriophage Mu] gi|1834293|dbj|BAA19197.1|; hypothetical protein 5064890..5065366 Escherichia coli O157:H7 str. Sakai 915002 NP_313009.1 CDS ECs4982 NC_002695.1 5065493 5067568 D similar to hypothetical proteins e.g. Gp42 (probable tape measure protein) [Bacteriophage Mu] gi|6010417|gb|AAF01120.1|AF083977_39; tape measure protein 5065493..5067568 Escherichia coli O157:H7 str. Sakai 915014 NP_313010.1 CDS ECs4983 NC_002695.1 5067534 5068904 D similar to DNA circulation proteins e.g. protein N? [Bacteriophage Mu] gi|6010418|gb|AAF01121.1|AF083977_40; DNA circulation protein 5067534..5068904 Escherichia coli O157:H7 str. Sakai 915011 NP_313011.1 CDS ECs4984 NC_002695.1 5068888 5070012 D similar to tail proteins e.g. P protein [Bacteriophage Mu] gi|139353|sp|P08558|VPP_BPMU; tail protein 5068888..5070012 Escherichia coli O157:H7 str. Sakai 915017 NP_313012.1 CDS ECs4985 NC_002695.1 5070002 5070616 D similar to hypothetical proteins e.g. gp45 [Bacteriophage Mu] gi|6010420|gb|AAF01123.1|AF083977_42; may be involved in base plate assemblyy; hypothetical protein 5070002..5070616 Escherichia coli O157:H7 str. Sakai 915020 NP_313013.1 CDS ECs4986 NC_002695.1 5070609 5071046 D similar to hypothetical proteins e.g. Gp46 [Bacteriophage Mu] gi|6010421|gb|AAF01124.1|AF083977_43; hypothetical protein 5070609..5071046 Escherichia coli O157:H7 str. Sakai 916542 NP_313014.1 CDS ECs4987 NC_002695.1 5071043 5072128 D similar to hypothetical proteins e.g. Gp47 [Bacteriophage Mu] gi|6010422|gb|AAF01125.1|AF083977_44; hypothetical protein 5071043..5072128 Escherichia coli O157:H7 str. Sakai 916556 NP_313015.1 CDS ECs4988 NC_002695.1 5072119 5072679 D similar to hypothetical proteins e.g. Gp48 [Bacteriophage Mu] gi|6010423|gb|AAF01126.1|AF083977_45; hypothetical protein 5072119..5072679 Escherichia coli O157:H7 str. Sakai 916560 NP_313016.1 CDS ECs4989 NC_002695.1 5072679 5073590 D similar to S protein [Bacteriophage Mu] gi|6010424|gb|AAF01127.1|AF083977_46, hypothetical proteins e.g. Bcv [Shigella boydii] gi|96900|pir||A42463; tail fiber 5072679..5073590 Escherichia coli O157:H7 str. Sakai 916096 NP_313017.1 CDS ECs4990 NC_002695.1 5073625 5074146 R similar to [Bacteriophage 186] gi|3522882|gb|AAC34165.1|, tail fiber assembly proteins e.g. U protein [Bacteriophage Mu] gi|6010425|gb|AAF01128.1; tail fiber assembly protein complement(5073625..5074146) Escherichia coli O157:H7 str. Sakai 916086 NP_313018.1 CDS ECs4991 NC_002695.1 5074226 5074429 R similar to carboxyl terminal part of tail fiber proteins e.g. S [Bacteriophage Mu] gi|6010424|gb|AAF01127.1|AF083977_46; tail fiber protein complement(5074226..5074429) Escherichia coli O157:H7 str. Sakai 914360 NP_313019.1 CDS ECs4992 NC_002695.1 5074651 5075211 D similar to site-specific recombinases e.g. DNA-invertase Gin [Bacteriophage Mu] gi|6010426|gb|AAF01129.1|AF083977_50; DNA-invertase 5074651..5075211 Escherichia coli O157:H7 str. Sakai 914359 NP_313020.1 CDS ECs4993 NC_002695.1 5075311 5077350 D similar to hypothetical proteins e.g. L0105 [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 5075311..5077350 Escherichia coli O157:H7 str. Sakai 914356 NP_313021.1 CDS ECs4994 NC_002695.1 5077497 5077679 D similar to orf25 [Bacteriophage 933W] gi|4499806|emb|CAB39305.1|; hypothetical protein 5077497..5077679 Escherichia coli O157:H7 str. Sakai 915036 NP_313022.1 CDS ECs4995 NC_002695.1 5077715 5077960 D similar to hypothetical proteins e.g. L0106 [Bacteriophage 933W] gi|4585420|gb|AAD25448.1|AF125520_43; hypothetical protein 5077715..5077960 Escherichia coli O157:H7 str. Sakai 915042 NP_313023.1 CDS ECs4996 NC_002695.1 5077999 5078310 R hypothetical protein complement(5077999..5078310) Escherichia coli O157:H7 str. Sakai 914351 NP_313024.1 CDS ECs4997 NC_002695.1 5078578 5078778 D similar to translational regulators e.g. Com protein (translational regulator of Mom) [Bacteriophage Mu] gi|7388376|sp|Q53979|VCOM_SHIDY; translational regulator 5078578..5078778 Escherichia coli O157:H7 str. Sakai 916446 NP_944580.1 CDS ECs5581 NC_002695.1 5078681 5078917 R hypothetical protein complement(5078681..5078917) Escherichia coli O157:H7 str. Sakai 2693779 NP_313025.1 CDS ECs4998 NC_002695.1 5078732 5079469 D similar to DNA modification proteins e.g. Mom protein [Bacteriophage Mu] gi|138782|sp|P06018|VMOM_BPMU; DNA modification protein 5078732..5079469 Escherichia coli O157:H7 str. Sakai 916307 NP_313027.1 CDS ECs5000 NC_002695.1 5079801 5080598 R similar to sorbose-permease IIC components e.g. [Klebsiella pneumoniae] gi|548633|sp|P37082|PTRC_KLEPN; sorbose-permease PTS system IIC component complement(5079801..5080598) Escherichia coli O157:H7 str. Sakai 914348 NP_313028.1 CDS ECs5001 NC_002695.1 5080664 5081158 R similar to sorbose-permease IIB components e.g. [Klebsiella pneumoniae] gi|1142714|gb|AAB04152.1|; sorbose-permease PTS system IIB component complement(5080664..5081158) Escherichia coli O157:H7 str. Sakai 914345 NP_313029.1 CDS ECs5002 NC_002695.1 5081158 5081565 R similar to sorbose-permease IIA components, e.g. [Klebsiella pneumoniae] gi|548631|sp|P37080|PTRA_KLEPN; sorbose-permease PTS system IIA component complement(5081158..5081565) Escherichia coli O157:H7 str. Sakai 915026 NP_313030.1 CDS ECs5003 NC_002695.1 5081575 5082381 R Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase complement(5081575..5082381) Escherichia coli O157:H7 str. Sakai 914342 NP_313031.2 CDS ECs5004 NC_002695.1 5082451 5083419 R similar to sor-operon regulators (SorC family) [Klebsiella pneumoniae] gi|548950|sp|P37078|SORC_KLEPN; sor-operon regulator complement(5082451..5083419) Escherichia coli O157:H7 str. Sakai 914341 NP_313032.1 CDS ECs5005 NC_002695.1 5083746 5084618 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 5083746..5084618 Escherichia coli O157:H7 str. Sakai 914336 NP_313033.1 CDS ECs5006 NC_002695.1 5084619 5084891 R similar to YJBD_ECOLI gi|1790454 (conserved in Escherichia coli K-12); hypothetical protein complement(5084619..5084891) Escherichia coli O157:H7 str. Sakai 914332 NP_313034.1 CDS ECs5007 NC_002695.1 5085144 5086493 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase complement(5085144..5086493) Escherichia coli O157:H7 str. Sakai 914331 NP_313035.1 CDS pgi NC_002695.1 5087018 5088667 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 5087018..5088667 Escherichia coli O157:H7 str. Sakai 914328 NP_313036.1 CDS ECs5009 NC_002695.1 5089180 5089422 D similar to YJBE_ECOLI gi|1790458 (conserved in Escherichia coli K-12); hypothetical protein 5089180..5089422 Escherichia coli O157:H7 str. Sakai 914327 NP_313037.2 CDS ECs5010 NC_002695.1 5089536 5090174 D similar to YJBF_ECOLI gi|1790459 (conserved in Escherichia coli K-12); hypothetical protein 5089536..5090174 Escherichia coli O157:H7 str. Sakai 914326 NP_313038.1 CDS ECs5011 NC_002695.1 5090171 5090908 D similar to YJBG_ECOLI gi|1790460 (conserved in Escherichia coli K-12); hypothetical protein 5090171..5090908 Escherichia coli O157:H7 str. Sakai 914325 NP_313039.1 CDS ECs5012 NC_002695.1 5090908 5093004 D similar to YJBH_ECOLI gi|1790461 (conserved in Escherichia coli K-12); hypothetical protein 5090908..5093004 Escherichia coli O157:H7 str. Sakai 914323 NP_313040.1 CDS ECs5013 NC_002695.1 5093599 5094009 D similar to YJBA_ECOLI gi|1790462 (conserved in Escherichia coli K-12); phosphate-starvation-inducible protein PsiE 5093599..5094009 Escherichia coli O157:H7 str. Sakai 914322 NP_313041.1 CDS xylE NC_002695.1 5094053 5095528 R xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE complement(5094053..5095528) Escherichia coli O157:H7 str. Sakai 914320 NP_313042.1 CDS malG NC_002695.1 5095900 5096790 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(5095900..5096790) Escherichia coli O157:H7 str. Sakai 914319 NP_313043.1 CDS malF NC_002695.1 5096805 5098349 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(5096805..5098349) Escherichia coli O157:H7 str. Sakai 914318 NP_313044.1 CDS malE NC_002695.1 5098503 5099693 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(5098503..5099693) Escherichia coli O157:H7 str. Sakai 914317 NP_313045.1 CDS ECs5018 NC_002695.1 5100058 5101173 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 5100058..5101173 Escherichia coli O157:H7 str. Sakai 914316 NP_313046.1 CDS lamB NC_002695.1 5101245 5102585 D porin involved in the transport of maltose and maltodextrins; maltoporin 5101245..5102585 Escherichia coli O157:H7 str. Sakai 914315 NP_313047.1 CDS ECs5020 NC_002695.1 5102736 5103656 D similar to MALM_ECOLI gi|1790470 (conserved in Escherichia coli K-12); maltose regulon periplasmic protein 5102736..5103656 Escherichia coli O157:H7 str. Sakai 914314 NP_313048.1 CDS ECs5021 NC_002695.1 5103885 5105465 D in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 5103885..5105465 Escherichia coli O157:H7 str. Sakai 914313 NP_313049.2 CDS ubiC NC_002695.1 5105688 5106185 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 5105688..5106185 Escherichia coli O157:H7 str. Sakai 914312 NP_313050.1 CDS ubiA NC_002695.1 5106198 5107070 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 5106198..5107070 Escherichia coli O157:H7 str. Sakai 915051 NP_313051.2 CDS ECs5024 NC_002695.1 5107225 5109648 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(5107225..5109648) Escherichia coli O157:H7 str. Sakai 915055 NP_313052.1 CDS ECs5025 NC_002695.1 5109819 5110187 D similar to DGKA_ECOLI gi|1790475 (conserved in Escherichia coli K-12); diacylglycerol kinase 5109819..5110187 Escherichia coli O157:H7 str. Sakai 914310 NP_313053.1 CDS ECs5026 NC_002695.1 5110297 5110905 D Represses a number of genes involved in the response to DNA damage; LexA repressor 5110297..5110905 Escherichia coli O157:H7 str. Sakai 914309 NP_313054.2 CDS ECs5027 NC_002695.1 5110978 5112303 D similar to DINF_ECOLI gi|1790477 (conserved in Escherichia coli K-12); DNA-damage-inducible SOS response protein 5110978..5112303 Escherichia coli O157:H7 str. Sakai 914308 NP_313055.1 CDS ECs5028 NC_002695.1 5112419 5112628 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 5112419..5112628 Escherichia coli O157:H7 str. Sakai 914307 NP_313056.2 CDS ECs5029 NC_002695.1 5112670 5113185 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(5112670..5113185) Escherichia coli O157:H7 str. Sakai 914306 NP_313057.1 CDS ECs5030 NC_002695.1 5113504 5114400 D similar to YJBL_ECOLI gi|1790481, YJBM_ECOLI gi|1790482; hypothetical protein 5113504..5114400 Escherichia coli O157:H7 str. Sakai 914305 NP_313058.1 CDS ECs5031 NC_002695.1 5114823 5115860 D similar to YJBN_ECOLI gi|1790483 (conserved in Escherichia coli K-12); tRNA-dihydrouridine synthase A 5114823..5115860 Escherichia coli O157:H7 str. Sakai 914304 NP_313059.2 CDS pspG NC_002695.1 5115994 5116236 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 5115994..5116236 Escherichia coli O157:H7 str. Sakai 914303 NP_313060.1 CDS ECs5033 NC_002695.1 5116402 5117385 R similar to QOR_ECOLI gi|1790485 (conserved in Escherichia coli K-12); quinone oxidoreductase complement(5116402..5117385) Escherichia coli O157:H7 str. Sakai 914302 NP_313061.1 CDS ECs5034 NC_002695.1 5117468 5118883 D unwinds double stranded DNA; replicative DNA helicase 5117468..5118883 Escherichia coli O157:H7 str. Sakai 914301 NP_313062.1 CDS alr NC_002695.1 5118936 5120015 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 5118936..5120015 Escherichia coli O157:H7 str. Sakai 914300 NP_313063.1 CDS ECs5036 NC_002695.1 5120268 5121461 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 5120268..5121461 Escherichia coli O157:H7 str. Sakai 914299 NP_944581.1 CDS ECs5582 NC_002695.1 5121800 5122198 R hypothetical protein complement(5121800..5122198) Escherichia coli O157:H7 str. Sakai 2693780 NP_313064.1 CDS aphA NC_002695.1 5122560 5123273 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 5122560..5123273 Escherichia coli O157:H7 str. Sakai 914298 NP_313065.1 CDS ECs5038 NC_002695.1 5123384 5123800 D similar to YJBQ_ECOLI gi|1790491 (conserved in Escherichia coli K-12); hypothetical protein 5123384..5123800 Escherichia coli O157:H7 str. Sakai 914297 NP_313066.1 CDS ECs5039 NC_002695.1 5123804 5124160 D similar to YJBR_ECOLI gi|2367342 (conserved in Escherichia coli K-12); hypothetical protein 5123804..5124160 Escherichia coli O157:H7 str. Sakai 914296 NP_313067.1 CDS uvrA NC_002695.1 5124195 5127017 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(5124195..5127017) Escherichia coli O157:H7 str. Sakai 914295 NP_313068.1 CDS ECs5041 NC_002695.1 5127272 5127808 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 5127272..5127808 Escherichia coli O157:H7 str. Sakai 914294 NP_313069.2 CDS ECs5042 NC_002695.1 5127907 5128188 R similar to YJCB_ECOLI gi|1790495 (conserved in Escherichia coli K-12); hypothetical protein complement(5127907..5128188) Escherichia coli O157:H7 str. Sakai 916230 NP_313070.1 CDS ECs5043 NC_002695.1 5128617 5130203 D similar to YJCC_ECOLI gi|1790496 (conserved in Escherichia coli K-12); hypothetical protein 5128617..5130203 Escherichia coli O157:H7 str. Sakai 916287 NP_313071.1 CDS ECs5044 NC_002695.1 5130206 5130529 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(5130206..5130529) Escherichia coli O157:H7 str. Sakai 914293 NP_313072.1 CDS ECs5045 NC_002695.1 5130615 5131079 D similar to SOXR_ECOLI gi|1790498 (conserved in Escherichia coli K-12); redox-sensitive transcriptional activator SoxR 5130615..5131079 Escherichia coli O157:H7 str. Sakai 914292 NP_313073.1 CDS ECs5046 NC_002695.1 5131625 5132974 D similar to YJCD_ECOLI gi|1790499 (conserved in Escherichia coli K-12); hypothetical protein 5131625..5132974 Escherichia coli O157:H7 str. Sakai 914291 NP_313074.1 CDS ECs5047 NC_002695.1 5133125 5134774 D similar to YJCE_ECOLI gi|1790501 (conserved in Escherichia coli K-12); hypothetical protein 5133125..5134774 Escherichia coli O157:H7 str. Sakai 914279 NP_313075.1 CDS ECs5048 NC_002695.1 5134928 5136220 R similar to YJCF_ECOLI gi|1790502 (conserved in Escherichia coli K-12); hypothetical protein complement(5134928..5136220) Escherichia coli O157:H7 str. Sakai 914280 NP_313076.1 CDS actP NC_002695.1 5136401 5138050 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(5136401..5138050) Escherichia coli O157:H7 str. Sakai 914281 NP_313077.1 CDS ECs5050 NC_002695.1 5138047 5138361 R similar to YJCH_ECOLI gi|1790504 (conserved in Escherichia coli K-12); hypothetical protein complement(5138047..5138361) Escherichia coli O157:H7 str. Sakai 914283 NP_313078.1 CDS ECs5051 NC_002695.1 5138562 5140520 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(5138562..5140520) Escherichia coli O157:H7 str. Sakai 914284 NP_313079.1 CDS nrfA NC_002695.1 5140913 5142349 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 5140913..5142349 Escherichia coli O157:H7 str. Sakai 914290 NP_313080.1 CDS ECs5053 NC_002695.1 5142388 5142960 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 5142388..5142960 Escherichia coli O157:H7 str. Sakai 914289 NP_313081.1 CDS ECs5054 NC_002695.1 5142957 5143628 D similar to NRFC_ECOLI gi|2367345 (conserved in Escherichia coli K-12); formate-dependent nitrite reductase; NrfC 5142957..5143628 Escherichia coli O157:H7 str. Sakai 914288 NP_313082.1 CDS ECs5055 NC_002695.1 5143625 5144581 D similar to NRFD_ECOLI gi|1790509 (conserved in Escherichia coli K-12); hypothetical protein 5143625..5144581 Escherichia coli O157:H7 str. Sakai 914287 NP_313083.1 CDS ECs5056 NC_002695.1 5144661 5146319 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 5144661..5146319 Escherichia coli O157:H7 str. Sakai 914286 NP_313084.1 CDS ECs5057 NC_002695.1 5146312 5146695 D similar to NRFF_ECOLI gi|1790512 (conserved in Escherichia coli K-12); formate-dependent nitrite reductase complex subunit NrfF 5146312..5146695 Escherichia coli O157:H7 str. Sakai 914285 NP_313085.1 CDS ECs5058 NC_002695.1 5146692 5147288 D component of formate-dependent nitrite reductase complex; similar to NRFG_ECOLI gi|1790513 (conserved in Escherichia coli K-12); formate-dependent nitrite reductase complex subunit NrfG 5146692..5147288 Escherichia coli O157:H7 str. Sakai 914282 NP_313086.1 CDS gltP NC_002695.1 5147630 5148943 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 5147630..5148943 Escherichia coli O157:H7 str. Sakai 914266 NP_313087.1 CDS ECs5060 NC_002695.1 5149121 5149810 R similar to YJCO_ECOLI gi|1790515 (conserved in Escherichia coli K-12); hypothetical protein complement(5149121..5149810) Escherichia coli O157:H7 str. Sakai 914267 NP_313088.1 CDS ECs5061 NC_002695.1 5149904 5152051 R similar to FDHF_ECOLI gi|3868721 (conserved in Escherichia coli K-12); selenopolypeptide subunit of formate dehydrogenase H complement(5149904..5152051) Escherichia coli O157:H7 str. Sakai 914271 NP_313089.1 CDS ECs5062 NC_002695.1 5152249 5153715 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP complement(5152249..5153715) Escherichia coli O157:H7 str. Sakai 914272 NP_313090.2 CDS ECs5063 NC_002695.1 5153712 5155763 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(5153712..5155763) Escherichia coli O157:H7 str. Sakai 914278 NP_313091.1 CDS ECs5064 NC_002695.1 5155763 5156794 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(5155763..5156794) Escherichia coli O157:H7 str. Sakai 914275 NP_313092.1 CDS ECs5065 NC_002695.1 5156813 5157088 R hypothetical protein complement(5156813..5157088) Escherichia coli O157:H7 str. Sakai 916213 NP_313093.1 CDS ECs5066 NC_002695.1 5157297 5159294 R similar to YJCS_ECOLI gi|2367350 (conserved in Escherichia coli K-12); hypothetical protein complement(5157297..5159294) Escherichia coli O157:H7 str. Sakai 914274 NP_313094.1 CDS ECs5067 NC_002695.1 5159573 5160280 D similar to regulatory proteins e.g. aerobic respiration control protein [Zymomonas mobilis] gi|4511977|gb|AAD21537.1|; regulatory protein 5159573..5160280 Escherichia coli O157:H7 str. Sakai 914270 NP_313095.1 CDS ECs5068 NC_002695.1 5160277 5161278 R similar to sugar kinases e.g. fructokinase homolog ydjE [Bacillus subtilis] gi|3915420|sp|O34768|YDJE_BACSU; sugar kinase complement(5160277..5161278) Escherichia coli O157:H7 str. Sakai 914268 NP_313096.1 CDS ECs5069 NC_002695.1 5161275 5162135 R similar to aldolases e.g. fructose-bisphosphate aldolase (EC 4.1.2.13) FbaA [Bacillus subtilis] gi|543796|sp|P13243|ALF1_BACSU; hypothetical protein complement(5161275..5162135) Escherichia coli O157:H7 str. Sakai 914259 NP_313097.1 CDS ECs5070 NC_002695.1 5162150 5162833 R similar to hypothetical protein ydaE [Bacillus subtilis] gi|7474928|pir||E69768; hypothetical protein complement(5162150..5162833) Escherichia coli O157:H7 str. Sakai 914261 NP_313098.1 CDS ECs5071 NC_002695.1 5162888 5163829 R similar to carbohydrate binding protein, C-terminal part of bifunctional carbohydrate binding and transport protein Streptomyces coelicolor A3(2) CAB66286; carbohydrate binding protein complement(5162888..5163829) Escherichia coli O157:H7 str. Sakai 914260 NP_313099.1 CDS ECs5072 NC_002695.1 5163848 5164822 R similar to carbohydrate ABC transporters (permease) e.g. ribose ABC transporter (permease) rbsC [Bacillus subtilis] gi|7446897|pir||B69690; carbohydrate ABC transporter permease complement(5163848..5164822) Escherichia coli O157:H7 str. Sakai 914263 NP_313100.1 CDS ECs5073 NC_002695.1 5164819 5166339 R similar to sugar ABC transporter, ATP-binding proteins e.g. ribose ABC transporter (ATP-binding protein) rbsA [Bacillus subtilis] gi|7404442|sp|P36947|RBSA_BACSU; sugar ABC transporter ATP-binding protein complement(5164819..5166339) Escherichia coli O157:H7 str. Sakai 914265 NP_313101.1 CDS ECs5074 NC_002695.1 5166453 5168723 D similar to histidine protein kinases e.g. histidine protein kinase-response regulator hybrid protein CvgSY [Pseudomonas syringae pv. syringae] gi|5019771|gb|AAD37857.1|AF133263_2; histidine protein kinase 5166453..5168723 Escherichia coli O157:H7 str. Sakai 914264 NP_944582.1 CDS ECs5584 NC_002695.1 5168792 5169121 D hypothetical protein 5168792..5169121 Escherichia coli O157:H7 str. Sakai 2693816 NP_313102.1 CDS phnP NC_002695.1 5169198 5169956 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(5169198..5169956) Escherichia coli O157:H7 str. Sakai 912306 NP_313103.1 CDS ECs5076 NC_002695.1 5169958 5170383 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(5169958..5170383) Escherichia coli O157:H7 str. Sakai 916349 NP_313104.1 CDS ECs5077 NC_002695.1 5170380 5170937 R similar to PHNN_ECOLI gi|1790532 (conserved in Escherichia coli K-12); ribose 1,5-bisphosphokinase complement(5170380..5170937) Escherichia coli O157:H7 str. Sakai 914257 NP_313105.1 CDS ECs5078 NC_002695.1 5170937 5172073 R similar to PHNM_ECOLI gi|1790533 (conserved in Escherichia coli K-12); protein PhnM complement(5170937..5172073) Escherichia coli O157:H7 str. Sakai 916538 NP_313106.1 CDS ECs5079 NC_002695.1 5172070 5172750 R similar to PHNL_ECOLI gi|1790534 (conserved in Escherichia coli K-12); phosphonate ABC transporter ATP-binding protein complement(5172070..5172750) Escherichia coli O157:H7 str. Sakai 916548 NP_313107.1 CDS phnK NC_002695.1 5172861 5173619 R similar to PHNK_ECOLI gi|1790535 (conserved in Escherichia coli K-12); phosphonate C-P lyase system protein PhnK complement(5172861..5173619) Escherichia coli O157:H7 str. Sakai 914255 NP_313108.1 CDS ECs5081 NC_002695.1 5173616 5174461 R similar to PHNJ_ECOLI gi|1790536 (conserved in Escherichia coli K-12); protein PhnJ complement(5173616..5174461) Escherichia coli O157:H7 str. Sakai 914256 NP_313109.1 CDS ECs5082 NC_002695.1 5174454 5175518 R similar to PHNI_ECOLI gi|1790537 (conserved in Escherichia coli K-12); protein PhnI complement(5174454..5175518) Escherichia coli O157:H7 str. Sakai 914254 NP_313110.1 CDS phnH NC_002695.1 5175518 5176102 R similar to PHNH_ECOLI gi|1790538 (conserved in Escherichia coli K-12); carbon-phosphorus lyase complex subunit complement(5175518..5176102) Escherichia coli O157:H7 str. Sakai 914253 NP_313111.1 CDS ECs5084 NC_002695.1 5176099 5176551 R similar to PHNG_ECOLI gi|1790539 (conserved in Escherichia coli K-12); protein PhnG complement(5176099..5176551) Escherichia coli O157:H7 str. Sakai 914252 NP_313112.1 CDS ECs5085 NC_002695.1 5176552 5177277 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(5176552..5177277) Escherichia coli O157:H7 str. Sakai 914249 NP_313113.1 CDS ECs5086 NC_002695.1 5177298 5178128 R similar to PHNE_ECOLI (Strain B) SW: P16683, PHNE_ECOLI (strain K-12) gi|1790542, b4103_ECOLI (strain K-12) gi|179054; membrane channel protein component of Pn transporter complement(5177298..5178128) Escherichia coli O157:H7 str. Sakai 914246 NP_313114.1 CDS ECs5087 NC_002695.1 5178183 5179199 R similar to PHND_ECOLI gi|1790543 (conserved in Escherichia coli K-12); periplasmic binding protein component of Pn transporter complement(5178183..5179199) Escherichia coli O157:H7 str. Sakai 914245 NP_313115.1 CDS ECs5088 NC_002695.1 5179224 5180012 R similar to PHNC_ECOLI gi|1790544 (conserved in Escherichia coli K-12); phosphonate/organophosphate ester transporter subunit complement(5179224..5180012) Escherichia coli O157:H7 str. Sakai 914244 NP_313116.1 CDS ECs5089 NC_002695.1 5180145 5180588 R similar to PHNB_ECOLI gi|1790546 (conserved in Escherichia coli K-12); hypothetical protein complement(5180145..5180588) Escherichia coli O157:H7 str. Sakai 914243 NP_313117.1 CDS ECs5090 NC_002695.1 5180847 5181182 R similar to PHNA_ECOLI gi|1790547 (conserved in Escherichia coli K-12); hypothetical protein complement(5180847..5181182) Escherichia coli O157:H7 str. Sakai 914242 NP_313118.1 CDS ECs5091 NC_002695.1 5181584 5183812 D similar to YJDA_ECOLI gi|1790548 (conserved in Escherichia coli K-12); hypothetical protein 5181584..5183812 Escherichia coli O157:H7 str. Sakai 914241 NP_313119.2 CDS ECs5092 NC_002695.1 5183809 5184687 D similar to YJCZ_ECOLI gi|1790549 (conserved in Escherichia coli K-12); hypothetical protein 5183809..5184687 Escherichia coli O157:H7 str. Sakai 914240 NP_313120.1 CDS ECs5093 NC_002695.1 5184951 5186453 D similar to PROP_ECOLI gi|1790550 (conserved in Escherichia coli K-12); proline/glycine betaine transporter 5184951..5186453 Escherichia coli O157:H7 str. Sakai 914238 NP_313121.1 CDS ECs5094 NC_002695.1 5186630 5187721 R similar to BASS_ECOLI gi|1790551 (conserved in Escherichia coli K-12); sensor protein BasS/PmrB complement(5186630..5187721) Escherichia coli O157:H7 str. Sakai 914237 NP_313122.1 CDS ECs5095 NC_002695.1 5187731 5188399 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(5187731..5188399) Escherichia coli O157:H7 str. Sakai 913995 NP_313123.1 CDS ECs5096 NC_002695.1 5188396 5190069 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein complement(5188396..5190069) Escherichia coli O157:H7 str. Sakai 914018 NP_313124.1 CDS ECs5097 NC_002695.1 5190143 5191480 R similar to YJDE_ECOLI gi|2367353 (conserved in Escherichia coli K-12); arginine:agmatin antiporter complement(5190143..5191480) Escherichia coli O157:H7 str. Sakai 914204 NP_313125.1 CDS ECs5098 NC_002695.1 5191617 5192378 R similar to ADIY_ECOLI gi|1790557 (conserved in Escherichia coli K-12); AraC family transcriptional regulator complement(5191617..5192378) Escherichia coli O157:H7 str. Sakai 914236 NP_313126.1 CDS ECs5099 NC_002695.1 5192703 5194973 R similar to ADIA_ECOLI gi|1790558 (conserved in Escherichia coli K-12); biodegradative arginine decarboxylase complement(5192703..5194973) Escherichia coli O157:H7 str. Sakai 914235 NP_313127.1 CDS ECs5100 NC_002695.1 5195169 5196077 R similar to MELR_ECOLI gi|1790559 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator MelR complement(5195169..5196077) Escherichia coli O157:H7 str. Sakai 914234 NP_313128.1 CDS ECs5101 NC_002695.1 5196360 5197715 D similar to MELA_ECOLI gi|1790560 (conserved in Escherichia coli K-12); alpha-galactosidase 5196360..5197715 Escherichia coli O157:H7 str. Sakai 914230 NP_313129.1 CDS ECs5102 NC_002695.1 5197830 5199239 D similar to MELB_ECOLI gi|1790561 (conserved in Escherichia coli K-12); melibiose:sodium symporter 5197830..5199239 Escherichia coli O157:H7 str. Sakai 914229 NP_313130.1 CDS ECs5103 NC_002695.1 5199378 5200007 R similar to YJDF_ECOLI gi|1790562 (conserved in Escherichia coli K-12); hypothetical protein complement(5199378..5200007) Escherichia coli O157:H7 str. Sakai 914227 NP_313131.1 CDS ECs5104 NC_002695.1 5200130 5201776 R similar to FUMA_ECOLI gi|1787897 (conserved in Escherichia coli K-12); fumarase B complement(5200130..5201776) Escherichia coli O157:H7 str. Sakai 914223 NP_313132.1 CDS ECs5105 NC_002695.1 5201854 5203194 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(5201854..5203194) Escherichia coli O157:H7 str. Sakai 914219 NP_313133.1 CDS ECs5106 NC_002695.1 5203765 5204484 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DcuR family transcriptional regulator complement(5203765..5204484) Escherichia coli O157:H7 str. Sakai 914216 NP_313134.1 CDS ECs5107 NC_002695.1 5204481 5206112 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(5204481..5206112) Escherichia coli O157:H7 str. Sakai 914212 NP_313135.1 CDS ECs5108 NC_002695.1 5206293 5206523 D similar to YJDI_ECOLI gi|1790568 (conserved in Escherichia coli K-12); hypothetical protein 5206293..5206523 Escherichia coli O157:H7 str. Sakai 914209 NP_313136.1 CDS ECs5109 NC_002695.1 5206535 5206807 D similar to YJDJ_ECOLI gi|1790569 (conserved in Escherichia coli K-12); hypothetical protein 5206535..5206807 Escherichia coli O157:H7 str. Sakai 914201 NP_313137.1 CDS ECs5110 NC_002695.1 5207034 5207330 D similar to YJDK_ECOLI gi|1790570 (conserved in Escherichia coli K-12); hypothetical protein 5207034..5207330 Escherichia coli O157:H7 str. Sakai 914192 NP_313138.1 CDS lysS NC_002695.1 5207650 5209167 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(5207650..5209167) Escherichia coli O157:H7 str. Sakai 914181 NP_313139.1 CDS ECs5112 NC_002695.1 5209404 5210861 R similar to YJDL_ECOLI gi|1790572 (conserved in Escherichia coli K-12); peptide transporter complement(5209404..5210861) Escherichia coli O157:H7 str. Sakai 914180 NP_313140.1 CDS ECs5113 NC_002695.1 5210920 5213067 R similar to CADA_ECOLI gi|1790573 (conserved in Escherichia coli K-12); lysine decarboxylase 1 complement(5210920..5213067) Escherichia coli O157:H7 str. Sakai 914175 NP_313141.1 CDS cadB NC_002695.1 5213147 5214481 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(5213147..5214481) Escherichia coli O157:H7 str. Sakai 914165 NP_313142.1 CDS ECs5115 NC_002695.1 5214847 5216385 R regulates the cadBA operon; CadC family transcriptional regulator complement(5214847..5216385) Escherichia coli O157:H7 str. Sakai 914155 NP_313143.1 CDS ECs5116 NC_002695.1 5217184 5217783 R similar to YJDC_ECOLI gi|1790577 (conserved in Escherichia coli K-12); transcriptional regulator complement(5217184..5217783) Escherichia coli O157:H7 str. Sakai 914146 NP_313144.1 CDS dipZ NC_002695.1 5217796 5219493 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(5217796..5219493) Escherichia coli O157:H7 str. Sakai 914141 NP_313145.1 CDS ECs5118 NC_002695.1 5219469 5219807 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(5219469..5219807) Escherichia coli O157:H7 str. Sakai 914138 NP_313146.1 CDS ECs5119 NC_002695.1 5219923 5221224 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(5219923..5221224) Escherichia coli O157:H7 str. Sakai 914130 NP_313147.2 CDS aspA NC_002695.1 5221342 5222778 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(5221342..5222778) Escherichia coli O157:H7 str. Sakai 914128 NP_313148.1 CDS fxsA NC_002695.1 5223115 5223591 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 5223115..5223591 Escherichia coli O157:H7 str. Sakai 914126 NP_313149.1 CDS ECs5122 NC_002695.1 5223607 5224863 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein complement(5223607..5224863) Escherichia coli O157:H7 str. Sakai 912533 NP_313150.1 CDS groES NC_002695.1 5225139 5225432 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 5225139..5225432 Escherichia coli O157:H7 str. Sakai 913836 NP_313151.1 CDS groEL NC_002695.1 5225476 5227122 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 5225476..5227122 Escherichia coli O157:H7 str. Sakai 913705 NP_313152.1 CDS ECs5125 NC_002695.1 5227227 5227613 D similar to YJEI_ECOLI gi|1790587 (conserved in Escherichia coli K-12); hypothetical protein 5227227..5227613 Escherichia coli O157:H7 str. Sakai 914086 NP_313153.1 CDS ECs5126 NC_002695.1 5227806 5228675 R similar to YJEJ_ECOLI gi|1790588 (conserved in Escherichia coli K-12); hypothetical protein complement(5227806..5228675) Escherichia coli O157:H7 str. Sakai 914122 NP_313154.1 CDS ECs5127 NC_002695.1 5228910 5229938 R similar to YJEK_ECOLI gi|1790589 (conserved in Escherichia coli K-12); hypothetical protein complement(5228910..5229938) Escherichia coli O157:H7 str. Sakai 914115 NP_313155.1 CDS ECs5128 NC_002695.1 5229980 5230546 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 5229980..5230546 Escherichia coli O157:H7 str. Sakai 913175 NP_944583.1 CDS ECs5586 NC_002695.1 5230834 5230980 D entericidin B membrane lipoprotein 5230834..5230980 Escherichia coli O157:H7 str. Sakai 2693764 NP_313156.1 CDS ECs5129 NC_002695.1 5231006 5231473 D similar to SUGE_ECOLI gi|1790591 (conserved in Escherichia coli K-12); suppressor of groEL 5231006..5231473 Escherichia coli O157:H7 str. Sakai 913177 NP_313157.1 CDS ECs5130 NC_002695.1 5231470 5232003 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(5231470..5232003) Escherichia coli O157:H7 str. Sakai 913180 NP_313158.1 CDS ampC NC_002695.1 5232091 5233224 R similar to AMPC_ECOLI gi|1790593 (conserved in Escherichia coli K-12); beta-lactamase complement(5232091..5233224) Escherichia coli O157:H7 str. Sakai 914045 NP_313159.1 CDS ECs5132 NC_002695.1 5233287 5233646 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(5233287..5233646) Escherichia coli O157:H7 str. Sakai 913185 NP_313160.1 CDS ECs5133 NC_002695.1 5233657 5234052 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(5233657..5234052) Escherichia coli O157:H7 str. Sakai 914102 NP_313161.1 CDS ECs5134 NC_002695.1 5234063 5234797 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(5234063..5234797) Escherichia coli O157:H7 str. Sakai 914097 NP_313162.1 CDS ECs5135 NC_002695.1 5234790 5236598 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(5234790..5236598) Escherichia coli O157:H7 str. Sakai 915745 NP_313163.2 CDS ECs5136 NC_002695.1 5236923 5237900 D lysine--tRNA ligase subunit beta; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 5236923..5237900 Escherichia coli O157:H7 str. Sakai 915739 NP_313164.1 CDS ECs5137 NC_002695.1 5238077 5239621 D similar to YJEM_ECOLI gi|1790600 (conserved in Escherichia coli K-12); transport 5238077..5239621 Escherichia coli O157:H7 str. Sakai 915769 NP_313165.1 CDS ECs5138 NC_002695.1 5239772 5243095 R similar to YJEP_ECOLI gi|2367355 (conserved in Escherichia coli K-12); hypothetical protein complement(5239772..5243095) Escherichia coli O157:H7 str. Sakai 915767 NP_313166.1 CDS psd NC_002695.1 5243117 5244085 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(5243117..5244085) Escherichia coli O157:H7 str. Sakai 915779 NP_313167.2 CDS ECs5140 NC_002695.1 5244182 5245234 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(5244182..5245234) Escherichia coli O157:H7 str. Sakai 915785 NP_313168.2 CDS ECs5141 NC_002695.1 5245329 5245874 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 5245329..5245874 Escherichia coli O157:H7 str. Sakai 915776 NP_313169.1 CDS ECs5143 NC_002695.1 5246653 5247792 R similar to YJES_ECOLI gi|1790608 (conserved in Escherichia coli K-12); hypothetical protein complement(5246653..5247792) Escherichia coli O157:H7 str. Sakai 914085 NP_313170.1 CDS ECs5142 NC_002695.1 5247791 5249338 D similar to YJEF_ECOLI gi|1790609 (conserved in Escherichia coli K-12); hypothetical protein 5247791..5249338 Escherichia coli O157:H7 str. Sakai 914083 NP_313171.1 CDS ECs5144 NC_002695.1 5249310 5249771 D possibly involved in cell wall synthesis; ATPase 5249310..5249771 Escherichia coli O157:H7 str. Sakai 914082 NP_313172.1 CDS ECs5145 NC_002695.1 5249790 5251127 D similar to AMIB_ECOLI gi|1790611 (conserved in Escherichia coli K-12); N-acetylmuramoyl-l-alanine amidase II 5249790..5251127 Escherichia coli O157:H7 str. Sakai 914078 NP_313173.1 CDS mutL NC_002695.1 5251137 5252984 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 5251137..5252984 Escherichia coli O157:H7 str. Sakai 914075 NP_313174.1 CDS miaA NC_002695.1 5252977 5253927 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 5252977..5253927 Escherichia coli O157:H7 str. Sakai 914072 NP_313175.1 CDS hfq NC_002695.1 5254013 5254321 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 5254013..5254321 Escherichia coli O157:H7 str. Sakai 914061 NP_313176.1 CDS ECs5149 NC_002695.1 5254398 5255678 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 5254398..5255678 Escherichia coli O157:H7 str. Sakai 914058 NP_313177.1 CDS ECs5150 NC_002695.1 5255764 5257023 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 5255764..5257023 Escherichia coli O157:H7 str. Sakai 914055 NP_313178.1 CDS ECs5151 NC_002695.1 5257026 5258030 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 5257026..5258030 Escherichia coli O157:H7 str. Sakai 914054 NP_313179.1 CDS ECs5152 NC_002695.1 5258112 5258309 D similar to YJET_ECOLI gi|1790619 (conserved in Escherichia coli K-12); hypothetical protein 5258112..5258309 Escherichia coli O157:H7 str. Sakai 914051 NP_313180.1 CDS ECs5153 NC_002695.1 5258413 5259711 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 5258413..5259711 Escherichia coli O157:H7 str. Sakai 914042 NP_313181.1 CDS ECs5154 NC_002695.1 5259916 5260341 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 5259916..5260341 Escherichia coli O157:H7 str. Sakai 914030 NP_313182.2 CDS ECs5155 NC_002695.1 5260380 5262821 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 5260380..5262821 Escherichia coli O157:H7 str. Sakai 913825 NP_313183.1 CDS ECs5156 NC_002695.1 5263002 5263733 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 5263002..5263733 Escherichia coli O157:H7 str. Sakai 913444 NP_313184.1 CDS ECs5157 NC_002695.1 5263860 5264261 D similar to YJFI_ECOLI gi|1790624 (conserved in Escherichia coli K-12); hypothetical protein 5263860..5264261 Escherichia coli O157:H7 str. Sakai 913858 NP_313185.1 CDS ECs5158 NC_002695.1 5264280 5264978 D similar to YJFJ_ECOLI gi|1790625 (conserved in Escherichia coli K-12); hypothetical protein 5264280..5264978 Escherichia coli O157:H7 str. Sakai 913989 NP_313186.1 CDS ECs5159 NC_002695.1 5265029 5265688 D similar to YJFK_ECOLI gi|1790626 (conserved in Escherichia coli K-12); hypothetical protein 5265029..5265688 Escherichia coli O157:H7 str. Sakai 913851 NP_313187.1 CDS ECs5160 NC_002695.1 5265706 5266104 D similar to YJFL_ECOLI gi|1790627 (conserved in Escherichia coli K-12); hypothetical protein 5265706..5266104 Escherichia coli O157:H7 str. Sakai 913304 NP_313188.1 CDS ECs5161 NC_002695.1 5266114 5266752 D similar to YJFM_ECOLI gi|1790628 (conserved in Escherichia coli K-12); hypothetical protein 5266114..5266752 Escherichia coli O157:H7 str. Sakai 914025 NP_313189.1 CDS ECs5162 NC_002695.1 5266755 5267918 D similar to YJFC_ECOLI gi|1790629 (conserved in Escherichia coli K-12); synthetase/amidase 5266755..5267918 Escherichia coli O157:H7 str. Sakai 914024 NP_313190.3 CDS ECs5163 NC_002695.1 5267987 5269627 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 5267987..5269627 Escherichia coli O157:H7 str. Sakai 914022 NP_313191.2 CDS ECs5164 NC_002695.1 5269744 5270031 R similar to YJFN_ECOLI gi|1790631 (conserved in Escherichia coli K-12); hypothetical protein complement(5269744..5270031) Escherichia coli O157:H7 str. Sakai 914015 NP_313192.2 CDS ECs5165 NC_002695.1 5270168 5270497 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A complement(5270168..5270497) Escherichia coli O157:H7 str. Sakai 914014 NP_313193.1 CDS ECs5166 NC_002695.1 5270679 5271428 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 5270679..5271428 Escherichia coli O157:H7 str. Sakai 914013 NP_313194.1 CDS ECs5167 NC_002695.1 5271425 5272180 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(5271425..5272180) Escherichia coli O157:H7 str. Sakai 914012 NP_313195.1 CDS ECs5168 NC_002695.1 5272288 5273358 R similar to YJFR_ECOLI gi|1790636 (conserved in Escherichia coli K-12); L-ascorbate 6-phosphate lactonase complement(5272288..5273358) Escherichia coli O157:H7 str. Sakai 914011 NP_313196.2 CDS ulaA NC_002695.1 5273707 5275104 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 5273707..5275104 Escherichia coli O157:H7 str. Sakai 914004 NP_313197.1 CDS ECs5170 NC_002695.1 5275120 5275425 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 5275120..5275425 Escherichia coli O157:H7 str. Sakai 914003 NP_313198.1 CDS ECs5171 NC_002695.1 5275435 5275899 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 5275435..5275899 Escherichia coli O157:H7 str. Sakai 914001 NP_313199.1 CDS ulaD NC_002695.1 5275913 5276563 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 5275913..5276563 Escherichia coli O157:H7 str. Sakai 913999 NP_313200.1 CDS ECs5173 NC_002695.1 5276573 5277427 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 5276573..5277427 Escherichia coli O157:H7 str. Sakai 913998 NP_313201.1 CDS sgaE NC_002695.1 5277427 5278113 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 5277427..5278113 Escherichia coli O157:H7 str. Sakai 913993 NP_313202.1 CDS ECs5175 NC_002695.1 5278242 5278517 R similar to YJFY_ECOLI gi|1790643 (conserved in Escherichia coli K-12); hypothetical protein complement(5278242..5278517) Escherichia coli O157:H7 str. Sakai 913992 NP_313203.1 CDS rpsF NC_002695.1 5278844 5279239 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 5278844..5279239 Escherichia coli O157:H7 str. Sakai 913987 NP_313204.1 CDS ECs5177 NC_002695.1 5279246 5279560 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 5279246..5279560 Escherichia coli O157:H7 str. Sakai 913985 NP_313205.1 CDS rpsR NC_002695.1 5279565 5279792 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5279565..5279792 Escherichia coli O157:H7 str. Sakai 913982 NP_313206.1 CDS rplI NC_002695.1 5279834 5280283 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 5279834..5280283 Escherichia coli O157:H7 str. Sakai 913978 NP_313207.1 CDS ECs5180 NC_002695.1 5280354 5281148 R similar to YJFZ_ECOLI gi|1790648 (conserved in Escherichia coli K-12); hypothetical protein complement(5280354..5281148) Escherichia coli O157:H7 str. Sakai 913976 NP_313208.1 CDS ECs5181 NC_002695.1 5281522 5281917 D similar to YTFA_ECOLI gi|1790650; hypothetical protein 5281522..5281917 Escherichia coli O157:H7 str. Sakai 913973 NP_313209.1 CDS ECs5182 NC_002695.1 5281771 5282202 R TnpA of insertion sequence IS609; similar to transposase homolog A [Helicobacter pylori] gi|2114470|gb|AAD11513.1; transposase complement(5281771..5282202) Escherichia coli O157:H7 str. Sakai 913967 NP_313210.2 CDS ECs5183 NC_002695.1 5282210 5283418 D TnpB of insertion sequence IS609; similar to B1432_ECOLI gi|1787702, transposases Xylella fastidiosa AAF83346; transposase 5282210..5283418 Escherichia coli O157:H7 str. Sakai 913966 NP_313211.1 CDS ECs5184 NC_002695.1 5283553 5284227 R similar to YTFB_ECOLI gi|1790651 (conserved in Escherichia coli K-12); hypothetical protein complement(5283553..5284227) Escherichia coli O157:H7 str. Sakai 913964 NP_313212.2 CDS ECs5185 NC_002695.1 5284409 5285029 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 5284409..5285029 Escherichia coli O157:H7 str. Sakai 913963 NP_313213.1 CDS ECs5186 NC_002695.1 5285338 5286750 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 5285338..5286750 Escherichia coli O157:H7 str. Sakai 913962 NP_313214.1 CDS ECs5187 NC_002695.1 5286795 5287457 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(5286795..5287457) Escherichia coli O157:H7 str. Sakai 913956 NP_313215.1 CDS ECs5188 NC_002695.1 5287565 5288539 R similar to YTFF_ECOLI gi|1790655 (conserved in Escherichia coli K-12); transmembrane subunit complement(5287565..5288539) Escherichia coli O157:H7 str. Sakai 913955 NP_313216.1 CDS ECs5190 NC_002695.1 5288638 5289498 R similar to YTFG_ECOLI gi|1790656 (conserved in Escherichia coli K-12); oxidoreductase complement(5288638..5289498) Escherichia coli O157:H7 str. Sakai 913947 NP_313217.2 CDS ECs5189 NC_002695.1 5289587 5289967 D similar to YTFH_ECOLI gi|1790657 (conserved in Escherichia coli K-12); hypothetical protein 5289587..5289967 Escherichia coli O157:H7 str. Sakai 913946 NP_313218.1 CDS cpdB NC_002695.1 5290085 5292028 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(5290085..5292028) Escherichia coli O157:H7 str. Sakai 913944 NP_313219.1 CDS ECs5192 NC_002695.1 5292218 5292958 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 5292218..5292958 Escherichia coli O157:H7 str. Sakai 913943 NP_313220.1 CDS ECs5193 NC_002695.1 5293170 5294108 D similar to YTFI_ECOLI gi|1790661; hypothetical protein 5293170..5294108 Escherichia coli O157:H7 str. Sakai 913942 NP_313221.1 CDS ECs5194 NC_002695.1 5294171 5294725 R similar to YTFJ_ECOLI gi|1790662 (conserved in Escherichia coli K-12); hypothetical protein complement(5294171..5294725) Escherichia coli O157:H7 str. Sakai 913940 NP_313222.1 CDS ECs5195 NC_002695.1 5295011 5295256 D similar to YTFK_ECOLI gi|1790663 (conserved in Escherichia coli K-12); hypothetical protein 5295011..5295256 Escherichia coli O157:H7 str. Sakai 913816 NP_313223.1 CDS ECs5196 NC_002695.1 5295352 5296695 R similar to YTFL_ECOLI gi|1790664 (conserved in Escherichia coli K-12); transporter complement(5295352..5296695) Escherichia coli O157:H7 str. Sakai 913900 NP_313224.1 CDS ECs5197 NC_002695.1 5297018 5297656 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(5297018..5297656) Escherichia coli O157:H7 str. Sakai 913935 NP_313225.1 CDS ECs5198 NC_002695.1 5297862 5299595 D similar to YTFM_ECOLI gi|1790666 (conserved in Escherichia coli K-12); hypothetical protein 5297862..5299595 Escherichia coli O157:H7 str. Sakai 913933 NP_313226.1 CDS ECs5199 NC_002695.1 5299592 5303371 D similar to YTFN_ECOLI gi|1790667 (conserved in Escherichia coli K-12); hypothetical protein 5299592..5303371 Escherichia coli O157:H7 str. Sakai 913926 NP_313227.1 CDS ECs5200 NC_002695.1 5303374 5303715 D similar to YTFP_ECOLI gi|1790668 (conserved in Escherichia coli K-12); hypothetical protein 5303374..5303715 Escherichia coli O157:H7 str. Sakai 913921 NP_313228.1 CDS ECs5201 NC_002695.1 5303456 5303725 R similar to YJFA_ECOLI gi|1790669 (conserved in Escherichia coli K-12); hypothetical protein complement(5303456..5303725) Escherichia coli O157:H7 str. Sakai 913915 NP_313229.1 CDS ECs5202 NC_002695.1 5303921 5304178 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 5303921..5304178 Escherichia coli O157:H7 str. Sakai 913912 NP_313230.1 CDS ECs5203 NC_002695.1 5304172 5304522 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 5304172..5304522 Escherichia coli O157:H7 str. Sakai 913901 NP_313231.1 CDS ECs5204 NC_002695.1 5304602 5305132 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(5304602..5305132) Escherichia coli O157:H7 str. Sakai 913899 NP_313232.1 CDS ECs5205 NC_002695.1 5305442 5306398 D similar to YTFQ_ECOLI gi|1790674 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator 5305442..5306398 Escherichia coli O157:H7 str. Sakai 913898 NP_313233.1 CDS ECs5206 NC_002695.1 5306538 5308040 D similar to YTFR_ECOLI gi|1790675, YTFS_ECOLI gi|1790676; ABC transporter ATP-binding protein 5306538..5308040 Escherichia coli O157:H7 str. Sakai 913896 NP_313234.1 CDS ECs5207 NC_002695.1 5308051 5309076 D similar to YTFT_ECOLI gi|1790677 (conserved in Escherichia coli K-12); transport system permease 5308051..5309076 Escherichia coli O157:H7 str. Sakai 913880 NP_313235.1 CDS ECs5208 NC_002695.1 5309087 5310058 D membrane component of a sugar ABC transporter system; ABC transporter permease 5309087..5310058 Escherichia coli O157:H7 str. Sakai 913878 NP_313236.1 CDS ECs5209 NC_002695.1 5310091 5311089 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(5310091..5311089) Escherichia coli O157:H7 str. Sakai 913877 NP_313237.1 CDS ECs5210 NC_002695.1 5311265 5312638 D similar to YJFG_ECOLI gi|1790680 (conserved in Escherichia coli K-12); UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 5311265..5312638 Escherichia coli O157:H7 str. Sakai 913873 NP_313238.1 CDS ECs5211 NC_002695.1 5312794 5313345 R similar to YJGA_ECOLI gi|1790681 (conserved in Escherichia coli K-12); hypothetical protein complement(5312794..5313345) Escherichia coli O157:H7 str. Sakai 913871 NP_313239.1 CDS ECs5212 NC_002695.1 5313439 5314791 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 5313439..5314791 Escherichia coli O157:H7 str. Sakai 913868 NP_313240.2 CDS ECs5213 NC_002695.1 5314975 5315361 D similar to CYBC_ECOLI gi|1790684 (conserved in Escherichia coli K-12); cytochrome b(562) 5314975..5315361 Escherichia coli O157:H7 str. Sakai 913867 NP_313241.1 CDS nrdG NC_002695.1 5315406 5315870 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(5315406..5315870) Escherichia coli O157:H7 str. Sakai 913866 NP_313242.1 CDS ECs5215 NC_002695.1 5316060 5318198 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(5316060..5318198) Escherichia coli O157:H7 str. Sakai 913864 NP_313243.1 CDS ECs5216 NC_002695.1 5318592 5320247 R similar to TREC_ECOLI gi|1790687 (conserved in Escherichia coli K-12); trehalose-6-phosphate hydrolase complement(5318592..5320247) Escherichia coli O157:H7 str. Sakai 913860 NP_313244.1 CDS ECs5217 NC_002695.1 5320297 5321718 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC complement(5320297..5321718) Escherichia coli O157:H7 str. Sakai 913859 NP_313245.1 CDS treR NC_002695.1 5321837 5322784 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(5321837..5322784) Escherichia coli O157:H7 str. Sakai 913856 NP_313246.1 CDS ECs5219 NC_002695.1 5323163 5325859 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 5323163..5325859 Escherichia coli O157:H7 str. Sakai 913855 NP_313247.1 CDS ECs5220 NC_002695.1 5326065 5326490 R similar to YJGF_ECOLI gi|1790691 (conserved in Escherichia coli K-12); hypothetical protein complement(5326065..5326490) Escherichia coli O157:H7 str. Sakai 913846 NP_313248.1 CDS ECs5221 NC_002695.1 5326524 5326985 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase complement(5326524..5326985) Escherichia coli O157:H7 str. Sakai 913844 NP_313249.1 CDS pyrB NC_002695.1 5326998 5327933 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(5326998..5327933) Escherichia coli O157:H7 str. Sakai 913842 NP_313250.1 CDS ECs5224 NC_002695.1 5327937 5328071 R similar to PYRL_ECOLI gi|1790694 (conserved in Escherichia coli K-12); pyrBI operon leader peptide complement(5327937..5328071) Escherichia coli O157:H7 str. Sakai 913838 NP_313252.1 CDS ECs5225 NC_002695.1 5328352 5328747 R similar to YJGH_ECOLI gi|1790696 (conserved in Escherichia coli K-12); hypothetical protein complement(5328352..5328747) Escherichia coli O157:H7 str. Sakai 913830 NP_313253.1 CDS ECs5226 NC_002695.1 5328878 5329591 R similar to YJGI_ECOLI gi|2367365 (conserved in Escherichia coli K-12); oxidoreductase complement(5328878..5329591) Escherichia coli O157:H7 str. Sakai 913828 NP_313255.2 CDS ECs5228 NC_002695.1 5329662 5330255 D similar to YJGJ_ECOLI gi|1790700 (conserved in Escherichia coli K-12); hypothetical protein 5329662..5330255 Escherichia coli O157:H7 str. Sakai 913818 NP_313256.2 CDS ECs5229 NC_002695.1 5330400 5330852 D similar to YJGK_ECOLI gi|1790701 (conserved in Escherichia coli K-12); hypothetical protein 5330400..5330852 Escherichia coli O157:H7 str. Sakai 913815 NP_313257.1 CDS ECs5230 NC_002695.1 5330975 5332747 D similar to YJGL_ECOLI gi|1790702; hypothetical protein 5330975..5332747 Escherichia coli O157:H7 str. Sakai 913810 NP_313258.1 CDS ECs5231 NC_002695.1 5332804 5333808 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(5332804..5333808) Escherichia coli O157:H7 str. Sakai 913389 NP_313259.1 CDS ECs5232 NC_002695.1 5333970 5334386 D similar to YJGD_ECOLI gi|1790704 (conserved in Escherichia coli K-12); hypothetical protein 5333970..5334386 Escherichia coli O157:H7 str. Sakai 913392 NP_313260.2 CDS ECs5233 NC_002695.1 5334432 5334935 R similar to B4256_ECOLI gi|1790705 (conserved in Escherichia coli K-12); hypothetical protein complement(5334432..5334935) Escherichia coli O157:H7 str. Sakai 913397 NP_313261.1 CDS ECs5234 NC_002695.1 5335128 5336324 D similar to YJGN_ECOLI gi|2367367 (conserved in Escherichia coli K-12); hypothetical protein 5335128..5336324 Escherichia coli O157:H7 str. Sakai 913808 NP_313262.1 CDS valS NC_002695.1 5336379 5339234 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(5336379..5339234) Escherichia coli O157:H7 str. Sakai 913806 NP_313263.1 CDS ECs5236 NC_002695.1 5339234 5339677 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(5339234..5339677) Escherichia coli O157:H7 str. Sakai 913805 NP_313264.1 CDS ECs5237 NC_002695.1 5340031 5341542 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(5340031..5341542) Escherichia coli O157:H7 str. Sakai 913804 NP_313265.1 CDS ECs5238 NC_002695.1 5341809 5342909 D similar to YJGP_ECOLI gi|1790712 (conserved in Escherichia coli K-12); hypothetical protein 5341809..5342909 Escherichia coli O157:H7 str. Sakai 913803 NP_313266.2 CDS ECs5239 NC_002695.1 5342909 5343991 D similar to YJGQ_ECOLI gi|1790713 (conserved in Escherichia coli K-12); hypothetical protein 5342909..5343991 Escherichia coli O157:H7 str. Sakai 913802 NP_313267.1 CDS ECs5240 NC_002695.1 5344152 5345654 R similar to YJGR_ECOLI gi|1790714 (conserved in Escherichia coli K-12); hypothetical protein complement(5344152..5345654) Escherichia coli O157:H7 str. Sakai 913800 NP_313268.2 CDS ECs5241 NC_002695.1 5345784 5346803 R similar to YJGB_ECOLI gi|1790720 (conserved in Escherichia coli K-12); oxidoreductase complement(5345784..5346803) Escherichia coli O157:H7 str. Sakai 913797 NP_313269.1 CDS ECs5242 NC_002695.1 5347174 5349123 D similar to integrases e.g. integrase [Bacteriophage TPW22] gi|6465906|gb|AAF12706.1|AF066865_4; integrase 5347174..5349123 Escherichia coli O157:H7 str. Sakai 913791 NP_313270.1 CDS ECs5243 NC_002695.1 5349323 5349649 D OrfA protein of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase 5349323..5349649 Escherichia coli O157:H7 str. Sakai 913773 NP_313271.1 CDS ECs5244 NC_002695.1 5349646 5350536 D OrfB protein of insertion sequence IS629; similar to [Escherichia coli plasmid pO157] gi|7443862|pir||T00240; transposase 5349646..5350536 Escherichia coli O157:H7 str. Sakai 913771 NP_313272.1 CDS ECs5245 NC_002695.1 5350719 5351003 R hypothetical protein complement(5350719..5351003) Escherichia coli O157:H7 str. Sakai 913770 NP_313273.1 CDS ECs5246 NC_002695.1 5351218 5351550 R hypothetical protein complement(5351218..5351550) Escherichia coli O157:H7 str. Sakai 913768 NP_313274.1 CDS ECs5247 NC_002695.1 5352114 5352290 R hypothetical protein complement(5352114..5352290) Escherichia coli O157:H7 str. Sakai 913767 NP_313275.1 CDS ECs5248 NC_002695.1 5352554 5353021 R similar to hypothetical proteins [Staphylococcus aureus] e.g. gi|7594765|dbj|BAA94663.1|, hypothetical proteins [Neisseria meningitidis] gi|5051461|emb|CAB44981.1|; hypothetical protein complement(5352554..5353021) Escherichia coli O157:H7 str. Sakai 912719 NP_313276.1 CDS ECs5249 NC_002695.1 5353208 5353783 D similar to resolvases e.g. resolvase [Escherichia coli transposon Tn2501] gi|135944|sp|P05823|TNP0_ECOLI; resolvase 5353208..5353783 Escherichia coli O157:H7 str. Sakai 912720 NP_313277.1 CDS ECs5250 NC_002695.1 5353982 5355298 R hypothetical protein complement(5353982..5355298) Escherichia coli O157:H7 str. Sakai 912726 NP_313278.1 CDS ECs5251 NC_002695.1 5355450 5356223 R hypothetical protein complement(5355450..5356223) Escherichia coli O157:H7 str. Sakai 912567 NP_313279.1 CDS ECs5252 NC_002695.1 5356340 5356804 D similar to transcription regulators e.g. BamH I control element [Bacillus amyloliquefaciens] gi|116073|sp|P23939|CEBA_BACAM; transcriptional regulator 5356340..5356804 Escherichia coli O157:H7 str. Sakai 913764 NP_313280.1 CDS ECs5253 NC_002695.1 5357520 5358347 D similar to integrases e.g. [prophage P4] gi|732036|sp|P39347|INTB_ECOLI; integrase 5357520..5358347 Escherichia coli O157:H7 str. Sakai 913757 NP_944584.1 CDS ECs5591 NC_002695.1 5358407 5358574 D hypothetical protein 5358407..5358574 Escherichia coli O157:H7 str. Sakai 2693750 NP_313281.1 CDS ECs5254 NC_002695.1 5358807 5359658 R hypothetical protein complement(5358807..5359658) Escherichia coli O157:H7 str. Sakai 913753 NP_313282.1 CDS ECs5255 NC_002695.1 5359645 5359971 R similar to hypothetical proteins e.g. YjH [Escherichia coli] gi|7404491|sp|P39371|YJHT_ECOLI; hypothetical protein complement(5359645..5359971) Escherichia coli O157:H7 str. Sakai 913747 NP_313283.1 CDS ECs5256 NC_002695.1 5360199 5361302 R hypothetical protein complement(5360199..5361302) Escherichia coli O157:H7 str. Sakai 913745 NP_313284.1 CDS ECs5257 NC_002695.1 5361306 5362013 R similar to periplasmic protein [Campylobacter jejuni]gi|6968066|emb|CAB75235.1|; hypothetical protein complement(5361306..5362013) Escherichia coli O157:H7 str. Sakai 913743 NP_313285.1 CDS ECs5258 NC_002695.1 5362020 5363672 R similar to myosin heavy chains e.g. [Cyprinus carpio] gi|2351223|dbj|BAA22069.1|; hypothetical protein complement(5362020..5363672) Escherichia coli O157:H7 str. Sakai 913741 NP_313286.1 CDS ECs5259 NC_002695.1 5363890 5367243 D similar to YjiT [Escherichia coli] gi|732099|sp|P39391|YJIT_ECOLI; hypothetical protein 5363890..5367243 Escherichia coli O157:H7 str. Sakai 913738 NP_313287.1 CDS ECs5260 NC_002695.1 5367243 5373557 D similar to probable RNA helicase Deinococcus radiodurans strain R1 B75633, hypothetical YjiV protein Escherichia coli; hypothetical protein 5367243..5373557 Escherichia coli O157:H7 str. Sakai 913735 NP_313288.1 CDS ECs5261 NC_002695.1 5373808 5376639 D similar to ATP-dependent helicases e.g. [Halobacterium sp. (strain NRC-1) plasmid pNRC100] gi|7484100|pir||T08316; ATP-dependent helicase 5373808..5376639 Escherichia coli O157:H7 str. Sakai 913733 NP_313289.1 CDS ECs5262 NC_002695.1 5376642 5381576 D similar to hypothetical proteins e.g. H1130 [Halobacterium sp. (strain NRC-1) plasmid pNRC100] gi|7484076|pir||T08313, restriction /modification enzyme [Campylobacter jejuni] gi|6968147|e; hypothetical protein 5376642..5381576 Escherichia coli O157:H7 str. Sakai 913725 NP_313290.1 CDS ECs5263 NC_002695.1 5381576 5387917 D probable RNA helicase, similar to probable RNA helicases e.g. [Deinococcus radiodurans (strain R1)] gi|7473663|pir||B75633; RNA helicase 5381576..5387917 Escherichia coli O157:H7 str. Sakai 913721 NP_313291.1 CDS ECs5264 NC_002695.1 5387914 5390028 D similar to DNA helicases e.g. probable DNA helicase H91_ORF529 [Mycoplasma pneumoniae] gi|2495150|sp|P75438|YH91_MYCPN, helicase IV [Escherichia coli] gi|146328|gb|AAA23952.1|; DNA helicase 5387914..5390028 Escherichia coli O157:H7 str. Sakai 913716 NP_313292.1 CDS ECs5265 NC_002695.1 5390793 5390975 R similar to hypothetical protein YchG [Escherichia coli] gi|267475|sp|P30192|YCHG_ECOLI; hypothetical protein complement(5390793..5390975) Escherichia coli O157:H7 str. Sakai 913594 NP_313293.1 CDS ECs5266 NC_002695.1 5390981 5391211 R similar to hypothetical proteins e.g. YchG [Escherichia coli] gi|267475|sp|P30192|YCHG_ECOLI; hypothetical protein complement(5390981..5391211) Escherichia coli O157:H7 str. Sakai 913668 NP_313294.1 CDS ECs5267 NC_002695.1 5391157 5391399 R similar to hypothetical protein b1240 [Escherichia coli] gi|7466155|pir||C64871; hypothetical protein complement(5391157..5391399) Escherichia coli O157:H7 str. Sakai 913702 NP_944585.1 CDS ECs5592 NC_002695.1 5391319 5391504 D hypothetical protein 5391319..5391504 Escherichia coli O157:H7 str. Sakai 2693751 NP_313295.1 CDS ECs5268 NC_002695.1 5391522 5392502 R similar to YJHS_ECOLI gi|1790763 (conserved in Escherichia coli K-12); hypothetical protein complement(5391522..5392502) Escherichia coli O157:H7 str. Sakai 913701 NP_313296.1 CDS ECs5269 NC_002695.1 5392567 5393781 R similar to YJHT_ECOLI gi|1790764 (conserved in Escherichia coli K-12); N-acetylneuraminic acid mutarotase complement(5392567..5393781) Escherichia coli O157:H7 str. Sakai 913698 NP_313297.2 CDS ECs5270 NC_002695.1 5393693 5394409 R similar to YJHA_ECOLI gi|1790765 (conserved in Escherichia coli K-12); hypothetical protein complement(5393693..5394409) Escherichia coli O157:H7 str. Sakai 913696 NP_313298.1 CDS ECs5271 NC_002695.1 5395865 5396467 D inversion of on/off regulator of fimA; tyrosine recombinase 5395865..5396467 Escherichia coli O157:H7 str. Sakai 913695 NP_313299.1 CDS ECs5272 NC_002695.1 5396945 5397541 D inversion of on/off regulator of fimA; tyrosine recombinase 5396945..5397541 Escherichia coli O157:H7 str. Sakai 913692 NP_313300.1 CDS ECs5273 NC_002695.1 5398006 5398554 D similar to FIMA_ECOLI gi|1790769 (conserved in Escherichia coli K-12); major type 1 subunit fimbrin; FimA 5398006..5398554 Escherichia coli O157:H7 str. Sakai 913688 NP_313301.1 CDS ECs5274 NC_002695.1 5398511 5399158 D fimbrial protein; similar to FIMI_ECOLI gi|1790770 (conserved in Escherichia coli K-12); protein FimI 5398511..5399158 Escherichia coli O157:H7 str. Sakai 913687 NP_313302.2 CDS ECs5275 NC_002695.1 5399246 5399920 D periplasmic chaperone required for type 1 fimbriae; similar to FIMC_ECOLI gi|1790771 (conserved in Escherichia coli K-12); protein FimC 5399246..5399920 Escherichia coli O157:H7 str. Sakai 913685 NP_313303.1 CDS ECs5276 NC_002695.1 5399987 5402623 D similar to FIMD_ECOLI gi|1790772 (conserved in Escherichia coli K-12); protein FimD 5399987..5402623 Escherichia coli O157:H7 str. Sakai 913683 NP_313304.1 CDS ECs5277 NC_002695.1 5402633 5403163 D similar to FIMF_ECOLI gi|1790773 (conserved in Escherichia coli K-12); protein FimF 5402633..5403163 Escherichia coli O157:H7 str. Sakai 913682 NP_313305.1 CDS ECs5278 NC_002695.1 5403176 5403679 D similar to FIMG_ECOLI gi|1790774 (conserved in Escherichia coli K-12); protein FimG 5403176..5403679 Escherichia coli O157:H7 str. Sakai 913678 NP_313306.1 CDS ECs5279 NC_002695.1 5403699 5404601 D similar to FIMH_ECOLI gi|1790775 (conserved in Escherichia coli K-12); FimH; minor fimbrial subunit; D-mannose specific adhesin 5403699..5404601 Escherichia coli O157:H7 str. Sakai 913676 NP_313307.1 CDS ECs5280 NC_002695.1 5404775 5406118 R similar to GNTP_ECOLI gi|1790776 (conserved in Escherichia coli K-12); fructuronate transporter complement(5404775..5406118) Escherichia coli O157:H7 str. Sakai 913673 NP_313308.1 CDS ECs5281 NC_002695.1 5406458 5407642 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5406458..5407642 Escherichia coli O157:H7 str. Sakai 913672 NP_313309.1 CDS ECs5282 NC_002695.1 5407723 5409183 D similar to UXUB_ECOLI gi|1790779 (conserved in Escherichia coli K-12); D-mannonate oxidoreductase 5407723..5409183 Escherichia coli O157:H7 str. Sakai 913669 NP_313310.1 CDS ECs5283 NC_002695.1 5409398 5410171 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5409398..5410171 Escherichia coli O157:H7 str. Sakai 913667 NP_313311.2 CDS ECs5284 NC_002695.1 5410312 5411136 R similar to YJIC_ECOLI gi|1790781 (conserved in Escherichia coli K-12); hypothetical protein complement(5410312..5411136) Escherichia coli O157:H7 str. Sakai 913664 NP_313312.2 CDS iraD NC_002695.1 5411815 5412207 D inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5411815..5412207 Escherichia coli O157:H7 str. Sakai 913663 NP_313313.1 CDS ECs5286 NC_002695.1 5413176 5414348 R similar to IADA_ECOLI gi|1790784 (conserved in Escherichia coli K-12); isoaspartyl dipeptidase complement(5413176..5414348) Escherichia coli O157:H7 str. Sakai 913661 NP_313314.1 CDS ECs5287 NC_002695.1 5414361 5414822 R similar to YJIG_ECOLI gi|1790785 (conserved in Escherichia coli K-12); hypothetical protein complement(5414361..5414822) Escherichia coli O157:H7 str. Sakai 913654 NP_313315.1 CDS ECs5288 NC_002695.1 5414819 5415514 R similar to YJIH_ECOLI gi|1790786 (conserved in Escherichia coli K-12); hypothetical protein complement(5414819..5415514) Escherichia coli O157:H7 str. Sakai 913652 NP_313316.2 CDS ECs5289 NC_002695.1 5415707 5416096 D similar to N-terminal part of YJII_ECOLI gi|1790787; hypothetical protein 5415707..5416096 Escherichia coli O157:H7 str. Sakai 913651 NP_313317.1 CDS ECs5290 NC_002695.1 5416459 5421198 R similar toinvasin [Yersinia pseudotuberculosis] gi|79202|pir||A29646, probable membrane protein b1978 [Escherichia coli K-12] gi|1736642|dbj|BAA15799.1|; invasin complement(5416459..5421198) Escherichia coli O157:H7 str. Sakai 913650 NP_313318.1 CDS ECs5291 NC_002695.1 5421264 5421455 R hypothetical protein complement(5421264..5421455) Escherichia coli O157:H7 str. Sakai 913649 NP_313319.1 CDS ECs5292 NC_002695.1 5421500 5421700 R similar to probable membrane protein b1978 [Escherichia coli K-12] gi|1736642|dbj|BAA15799.1|; hypothetical protein complement(5421500..5421700) Escherichia coli O157:H7 str. Sakai 913648 NP_313320.1 CDS ECs5293 NC_002695.1 5421911 5423089 R similar to YJIJ_ECOLI gi|1790788 (conserved in Escherichia coli K-12); transporter complement(5421911..5423089) Escherichia coli O157:H7 str. Sakai 913647 NP_313321.1 CDS ECs5294 NC_002695.1 5423157 5424146 R similar to YJIK_ECOLI gi|1790790 (conserved in Escherichia coli K-12); hypothetical protein complement(5423157..5424146) Escherichia coli O157:H7 str. Sakai 913645 NP_313322.1 CDS ECs5295 NC_002695.1 5424265 5426472 R hypothetical protein complement(5424265..5426472) Escherichia coli O157:H7 str. Sakai 913644 NP_313323.1 CDS ECs5296 NC_002695.1 5426784 5427050 R hypothetical protein complement(5426784..5427050) Escherichia coli O157:H7 str. Sakai 913634 NP_313324.1 CDS ECs5297 NC_002695.1 5427047 5427814 R similar to YJIL_ECOLI gi|1790791 (conserved in Escherichia coli K-12); hypothetical protein complement(5427047..5427814) Escherichia coli O157:H7 str. Sakai 913632 NP_313325.2 CDS ECs5298 NC_002695.1 5427824 5428975 R similar to YJIM_ECOLI gi|1790792 (conserved in Escherichia coli K-12); hypothetical protein complement(5427824..5428975) Escherichia coli O157:H7 str. Sakai 913628 NP_313326.1 CDS ECs5299 NC_002695.1 5429091 5430362 R similar to YJIN_ECOLI gi|1790793 (conserved in Escherichia coli K-12); hypothetical protein complement(5429091..5430362) Escherichia coli O157:H7 str. Sakai 913627 NP_313327.1 CDS ECs5300 NC_002695.1 5430403 5431635 R similar to YJIO_ECOLI gi|1790794 (conserved in Escherichia coli K-12); transporter complement(5430403..5431635) Escherichia coli O157:H7 str. Sakai 913623 NP_313328.1 CDS ECs5301 NC_002695.1 5432102 5432884 D similar to YJIP_ECOLI gi|1790795, YJIQ_ECOLI gi|1790796; hypothetical protein 5432102..5432884 Escherichia coli O157:H7 str. Sakai 913622 NP_313329.1 CDS ECs5302 NC_002695.1 5433302 5434714 R similar to YJIR_ECOLI gi|1790797 (conserved in Escherichia coli K-12); regulator complement(5433302..5434714) Escherichia coli O157:H7 str. Sakai 913616 NP_313330.1 CDS ECs5303 NC_002695.1 5434891 5435055 D similar to YJIS_ECOLI gi|1790798 (conserved in Escherichia coli K-12); hypothetical protein 5434891..5435055 Escherichia coli O157:H7 str. Sakai 913613 NP_313331.1 CDS ECs5304 NC_002695.1 5435152 5436033 D similar to hypothetical proteins e.g. jhp0462 [Helicobacter pylori (strain J99)] gi|7464730|pir||C71929, jhp0572 [Helicobacter pylori (strain J99)] gi|7464757|pir||H71914; hypothetical protein 5435152..5436033 Escherichia coli O157:H7 str. Sakai 913612 NP_313332.1 CDS ECs5305 NC_002695.1 5436081 5437244 D similar to hypothetical protein e.g. jhp0462 [Helicobacter pylori (strain J99)] gi|7464730|pir||C71929, HP0513 [Helicobacter pylori (strain 26695)] gi|7464291|pir||A64584; hypothetical protein 5436081..5437244 Escherichia coli O157:H7 str. Sakai 913610 NP_944586.1 CDS ECs5593 NC_002695.1 5437291 5437632 R involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE complement(5437291..5437632) Escherichia coli O157:H7 str. Sakai 2693775 NP_313333.1 CDS ECs5306 NC_002695.1 5437853 5439607 R type I restriction-modification enzyme S subunits e.g. [Citrobacter freundii] pir|S06097|; type I restriction-modification enzyme S subunit complement(5437853..5439607) Escherichia coli O157:H7 str. Sakai 913608 NP_313334.1 CDS ECs5307 NC_002695.1 5439607 5441088 R similar to type I restriction modification enzyme M subunits e.g. [EcoA system] gi|421016|pir||A47200; type I restriction modification enzyme M subunit complement(5439607..5441088) Escherichia coli O157:H7 str. Sakai 913607 NP_313335.1 CDS ECs5308 NC_002695.1 5441143 5443575 R similar to type I restriction-modification enzyme R subunits e.g. [EcoA] gi|2121113|pir||I41291; type I restriction-modification enzyme R subunit complement(5441143..5443575) Escherichia coli O157:H7 str. Sakai 913604 NP_313336.1 CDS ECs5309 NC_002695.1 5443853 5444137 D similar to hypothetical proteins e.g. [Helicobacter pylori] gi|7464531|pir||E64694; hypothetical protein 5443853..5444137 Escherichia coli O157:H7 str. Sakai 913602 NP_313337.1 CDS ECs5310 NC_002695.1 5444146 5445504 D similar to hypothetical protein [Streptomyces coelicolor A3(2)] gi|7479715|pir||T35601; hypothetical protein 5444146..5445504 Escherichia coli O157:H7 str. Sakai 913601 NP_313338.2 CDS ECs5311 NC_002695.1 5445573 5446529 R similar to YJIA_ECOLI gi|1790812 (conserved in Escherichia coli K-12); GTP-binding protein YjiA complement(5445573..5446529) Escherichia coli O157:H7 str. Sakai 913598 NP_313339.1 CDS ECs5312 NC_002695.1 5446540 5446743 R similar to YJIX_ECOLI gi|1790813 (conserved in Escherichia coli K-12); hypothetical protein complement(5446540..5446743) Escherichia coli O157:H7 str. Sakai 913597 NP_313340.1 CDS ECs5313 NC_002695.1 5446793 5448958 R similar to YJIY_ECOLI gi|1790814 (conserved in Escherichia coli K-12); carbon starvation protein complement(5446793..5448958) Escherichia coli O157:H7 str. Sakai 913596 NP_313341.1 CDS ECs5314 NC_002695.1 5449236 5449778 R hypothetical protein complement(5449236..5449778) Escherichia coli O157:H7 str. Sakai 913593 NP_313342.1 CDS ECs5315 NC_002695.1 5450007 5451671 D similar to TSR_ECOLI gi|2367378 (conserved in Escherichia coli K-12); methyl-accepting chemotaxis protein I 5450007..5451671 Escherichia coli O157:H7 str. Sakai 913592 NP_313343.1 CDS ECs5316 NC_002695.1 5451720 5453081 R similar to YJIZ_ECOLI gi|2367379 (conserved in Escherichia coli K-12); transporter complement(5451720..5453081) Escherichia coli O157:H7 str. Sakai 913589 NP_313344.1 CDS ECs5317 NC_002695.1 5453296 5454102 R similar to YJJM_ECOLI gi|1790818 (conserved in Escherichia coli K-12); hypothetical protein complement(5453296..5454102) Escherichia coli O157:H7 str. Sakai 913586 NP_313345.1 CDS ECs5318 NC_002695.1 5454334 5455371 D similar to YJJN_ECOLI gi|1790819 (conserved in Escherichia coli K-12); oxidoreductase 5454334..5455371 Escherichia coli O157:H7 str. Sakai 913585 NP_313346.2 CDS ECs5319 NC_002695.1 5455508 5457799 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(5455508..5457799) Escherichia coli O157:H7 str. Sakai 913581 NP_313347.1 CDS ECs5320 NC_002695.1 5458053 5458550 R similar to YJJA_ECOLI gi|1790822 (conserved in Escherichia coli K-12); hypothetical protein complement(5458053..5458550) Escherichia coli O157:H7 str. Sakai 915005 NP_313348.1 CDS ECs5321 NC_002695.1 5458596 5459333 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(5458596..5459333) Escherichia coli O157:H7 str. Sakai 913577 NP_313349.1 CDS ECs5322 NC_002695.1 5459336 5459875 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(5459336..5459875) Escherichia coli O157:H7 str. Sakai 913487 NP_313350.2 CDS ECs5323 NC_002695.1 5459982 5460455 R similar to YJJB_ECOLI gi|1790825 (conserved in Escherichia coli K-12); hypothetical protein complement(5459982..5460455) Escherichia coli O157:H7 str. Sakai 913526 NP_313351.2 CDS ECs5324 NC_002695.1 5460446 5461270 R similar to YJJP_ECOLI gi|1790826 (conserved in Escherichia coli K-12); structural protein complement(5460446..5461270) Escherichia coli O157:H7 str. Sakai 913576 NP_313352.1 CDS ECs5325 NC_002695.1 5461837 5462562 D similar to YJJQ_ECOLI gi|1790827 (conserved in Escherichia coli K-12); regulator 5461837..5462562 Escherichia coli O157:H7 str. Sakai 913573 NP_313353.2 CDS ECs5326 NC_002695.1 5462574 5463197 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; BglJ family transcriptional regulator 5462574..5463197 Escherichia coli O157:H7 str. Sakai 913571 NP_313354.1 CDS ECs5327 NC_002695.1 5463235 5464023 R similar to FHUF_ECOLI gi|1790829 (conserved in Escherichia coli K-12); ferric hydroximate transport ferric iron reductase complement(5463235..5464023) Escherichia coli O157:H7 str. Sakai 913570 NP_313355.2 CDS ECs5328 NC_002695.1 5464125 5464400 D similar to YJJZ_ECOLI gi|2495668|sp|P55914 (conserved in Escherichia coli K-12); hypothetical protein 5464125..5464400 Escherichia coli O157:H7 str. Sakai 913561 NP_313356.1 CDS rsmC NC_002695.1 5464715 5465746 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(5464715..5465746) Escherichia coli O157:H7 str. Sakai 913556 NP_313357.1 CDS ECs5330 NC_002695.1 5465849 5466262 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5465849..5466262 Escherichia coli O157:H7 str. Sakai 913550 NP_313358.1 CDS rimI NC_002695.1 5466231 5466677 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5466231..5466677 Escherichia coli O157:H7 str. Sakai 913548 NP_313359.1 CDS ECs5332 NC_002695.1 5466692 5467369 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5466692..5467369 Escherichia coli O157:H7 str. Sakai 913547 NP_313360.1 CDS prfC NC_002695.1 5467460 5469049 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5467460..5469049 Escherichia coli O157:H7 str. Sakai 913543 NP_313361.1 CDS ECs5334 NC_002695.1 5469442 5470047 D similar to OSMY_ECOLI gi|1790836 (conserved in Escherichia coli K-12); hypothetical protein 5469442..5470047 Escherichia coli O157:H7 str. Sakai 913532 NP_313362.1 CDS ECs5335 NC_002695.1 5470457 5471530 D similar to YJJU_ECOLI gi|1790837 (conserved in Escherichia coli K-12); hypothetical protein 5470457..5471530 Escherichia coli O157:H7 str. Sakai 913522 NP_313363.1 CDS ECs5336 NC_002695.1 5471671 5472309 D similar to YJJV_ECOLI gi|1790838; hypothetical protein 5471671..5472309 Escherichia coli O157:H7 str. Sakai 913519 NP_313364.1 CDS ECs5337 NC_002695.1 5472523 5473386 R similar to YJJW_ECOLI gi|1790839 (conserved in Escherichia coli K-12); activating enzyme complement(5472523..5473386) Escherichia coli O157:H7 str. Sakai 913512 NP_313367.1 CDS ECs5340 NC_002695.1 5475165 5475944 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5475165..5475944 Escherichia coli O157:H7 str. Sakai 913508 NP_944587.1 CDS ECs5595 NC_002695.1 5476071 5476202 D hypothetical protein 5476071..5476202 Escherichia coli O157:H7 str. Sakai 2693797 NP_313368.1 CDS deoA NC_002695.1 5476199 5477392 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5476199..5477392 Escherichia coli O157:H7 str. Sakai 913506 NP_313369.1 CDS ECs5342 NC_002695.1 5477444 5478667 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5477444..5478667 Escherichia coli O157:H7 str. Sakai 913501 NP_313370.1 CDS deoD NC_002695.1 5478724 5479443 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5478724..5479443 Escherichia coli O157:H7 str. Sakai 913500 NP_313371.1 CDS ECs5344 NC_002695.1 5479604 5479867 R hypothetical protein complement(5479604..5479867) Escherichia coli O157:H7 str. Sakai 913499 NP_313372.1 CDS ECs5345 NC_002695.1 5479899 5481587 R in E. coli the lipoate ligase A catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes; creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; unknown domain/lipoate-protein ligase A fusion protein complement(5479899..5481587) Escherichia coli O157:H7 str. Sakai 913498 NP_313373.1 CDS serB NC_002695.1 5481693 5482661 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5481693..5482661 Escherichia coli O157:H7 str. Sakai 913496 NP_313374.1 CDS ECs5347 NC_002695.1 5482710 5484092 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5482710..5484092 Escherichia coli O157:H7 str. Sakai 913495 NP_313375.2 CDS ECs5348 NC_002695.1 5484113 5485345 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5484113..5485345 Escherichia coli O157:H7 str. Sakai 913494 NP_313376.1 CDS ECs5349 NC_002695.1 5485653 5487320 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(5485653..5487320) Escherichia coli O157:H7 str. Sakai 913493 NP_313377.2 CDS ECs5350 NC_002695.1 5487531 5489468 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5487531..5489468 Escherichia coli O157:H7 str. Sakai 913492 NP_313378.1 CDS ECs5351 NC_002695.1 5489558 5489884 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5489558..5489884 Escherichia coli O157:H7 str. Sakai 913491 NP_313379.2 CDS ECs5352 NC_002695.1 5490031 5490543 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(5490031..5490543) Escherichia coli O157:H7 str. Sakai 913489 NP_313380.1 CDS ECs5353 NC_002695.1 5490595 5491242 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5490595..5491242 Escherichia coli O157:H7 str. Sakai 913488 NP_313381.1 CDS ECs5354 NC_002695.1 5491239 5492108 R similar to ROB_ECOLI gi|1790857 (conserved in Escherichia coli K-12); right origin-binding protein complement(5491239..5492108) Escherichia coli O157:H7 str. Sakai 913486 NP_313382.1 CDS ECs5355 NC_002695.1 5492319 5492792 D similar to CREA_ECOLI gi|1790859 (conserved in Escherichia coli K-12); hypothetical protein 5492319..5492792 Escherichia coli O157:H7 str. Sakai 913485 NP_313383.1 CDS ECs5356 NC_002695.1 5492805 5493494 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5492805..5493494 Escherichia coli O157:H7 str. Sakai 913483 NP_313384.1 CDS ECs5357 NC_002695.1 5493494 5494918 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5493494..5494918 Escherichia coli O157:H7 str. Sakai 913481 NP_313385.1 CDS ECs5358 NC_002695.1 5494976 5496328 D similar to CRED_ECOLI gi|1790862 (conserved in Escherichia coli K-12); hypothetical protein 5494976..5496328 Escherichia coli O157:H7 str. Sakai 913480 NP_313386.1 CDS ECs5359 NC_002695.1 5496388 5497104 R similar to ARCA_ECOLI gi|1790863 (conserved in Escherichia coli K-12); two-component response regulator complement(5496388..5497104) Escherichia coli O157:H7 str. Sakai 913476 NP_313387.1 CDS ECs5360 NC_002695.1 5497200 5497340 D similar to YJJY_ECOLI gi|1790864 (conserved in Escherichia coli K-12); hypothetical protein 5497200..5497340 Escherichia coli O157:H7 str. Sakai 913475 NP_313388.1 CDS ECs5361 NC_002695.1 5497740 5498426 D member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 5497740..5498426 Escherichia coli O157:H7 str. Sakai 913472 ECs5367 tRNA ileV NC_002695.1 228712 228788 D tRNA-Ile 228712..228788 Escherichia coli O157:H7 str. Sakai 913984 ECs5368 tRNA alaV NC_002695.1 228831 228906 D tRNA-Ala 228831..228906 Escherichia coli O157:H7 str. Sakai 913988 ECs5371 tRNA aspU NC_002695.1 232257 232333 D tRNA-Asp 232257..232333 Escherichia coli O157:H7 str. Sakai 914020 ECs5372 tRNA aspV NC_002695.1 240481 240557 D tRNA-Asp 240481..240557 Escherichia coli O157:H7 str. Sakai 914060 ECs5373 tRNA thrW NC_002695.1 299982 300057 D tRNA-Thr 299982..300057 Escherichia coli O157:H7 str. Sakai 914369 ECs5379 tRNA argU NC_002695.1 657182 657258 D tRNA-Arg 657182..657258 Escherichia coli O157:H7 str. Sakai 916955 ECs5384 tRNA glnX NC_002695.1 776591 776665 R tRNA-Gln complement(776591..776665) Escherichia coli O157:H7 str. Sakai 917064 ECs5385 tRNA glnV NC_002695.1 776703 776777 R tRNA-Gln complement(776703..776777) Escherichia coli O157:H7 str. Sakai 917065 ECs5386 tRNA metU NC_002695.1 776826 776902 R tRNA-Met complement(776826..776902) Escherichia coli O157:H7 str. Sakai 917066 ECs5387 tRNA glnW NC_002695.1 776918 776992 R tRNA-Gln complement(776918..776992) Escherichia coli O157:H7 str. Sakai 917068 ECs5388 tRNA glnU NC_002695.1 777027 777101 R tRNA-Gln complement(777027..777101) Escherichia coli O157:H7 str. Sakai 917070 ECs5389 tRNA leuW NC_002695.1 777125 777209 R tRNA-Leu complement(777125..777209) Escherichia coli O157:H7 str. Sakai 917071 ECs5390 tRNA metT NC_002695.1 777220 777296 R tRNA-Met complement(777220..777296) Escherichia coli O157:H7 str. Sakai 917072 ECs5392 tRNA lysT NC_002695.1 864979 865054 D tRNA-Lys 864979..865054 Escherichia coli O157:H7 str. Sakai 917509 ECs5393 tRNA valT NC_002695.1 865090 865165 D tRNA-Val 865090..865165 Escherichia coli O157:H7 str. Sakai 917519 ECs5394 tRNA lysW NC_002695.1 865168 865243 D tRNA-Lys 865168..865243 Escherichia coli O157:H7 str. Sakai 917522 ECs5395 tRNA valZ NC_002695.1 865295 865370 D tRNA-Val 865295..865370 Escherichia coli O157:H7 str. Sakai 917524 ECs5396 tRNA lysY NC_002695.1 865374 865449 D tRNA-Lys 865374..865449 Escherichia coli O157:H7 str. Sakai 917513 ECs5397 tRNA lysZ NC_002695.1 865596 865671 D tRNA-Lys 865596..865671 Escherichia coli O157:H7 str. Sakai 917514 ECs5401 tRNA serW NC_002695.1 1056961 1057048 R tRNA-Ser complement(1056961..1057048) Escherichia coli O157:H7 str. Sakai 917709 ECs5403 tRNA ileZ1 NC_002695.1 1179418 1179493 D tRNA-Ile 1179418..1179493 Escherichia coli O157:H7 str. Sakai 912874 ECs5404 tRNA argN1 NC_002695.1 1179501 1179577 D tRNA-Arg 1179501..1179577 Escherichia coli O157:H7 str. Sakai 912934 ECs5405 tRNA argO1 NC_002695.1 1179591 1179667 D tRNA-Arg 1179591..1179667 Escherichia coli O157:H7 str. Sakai 913731 ECs5407 tRNA serT NC_002695.1 1210746 1210833 R tRNA-Ser complement(1210746..1210833) Escherichia coli O157:H7 str. Sakai 912503 ECs5408 tRNA ileZ2 NC_002695.1 1266623 1266698 D tRNA-Ile 1266623..1266698 Escherichia coli O157:H7 str. Sakai 913700 ECs5409 tRNA argN2 NC_002695.1 1266708 1266784 D tRNA-Arg 1266708..1266784 Escherichia coli O157:H7 str. Sakai 912984 ECs5410 tRNA argO2 NC_002695.1 1266798 1266874 D tRNA-Arg 1266798..1266874 Escherichia coli O157:H7 str. Sakai 914023 ECs5416 tRNA serX NC_002695.1 1456705 1456792 R tRNA-Ser complement(1456705..1456792) Escherichia coli O157:H7 str. Sakai 914009 ECs5424 tRNA tyrV NC_002695.1 1732289 1732373 R tRNA-Tyr complement(1732289..1732373) Escherichia coli O157:H7 str. Sakai 913126 ECs5425 tRNA tyrT NC_002695.1 1732583 1732667 R tRNA-Tyr complement(1732583..1732667) Escherichia coli O157:H7 str. Sakai 913125 ECs5429 tRNA ileZ3 NC_002695.1 1773942 1774017 D tRNA-Ile 1773942..1774017 Escherichia coli O157:H7 str. Sakai 913064 ECs5430 tRNA argO3 NC_002695.1 1774098 1774174 D tRNA-Arg 1774098..1774174 Escherichia coli O157:H7 str. Sakai 913054 ECs5434 tRNA ileZ4 NC_002695.1 1940568 1940643 D tRNA-Ile 1940568..1940643 Escherichia coli O157:H7 str. Sakai 917155 ECs5435 tRNA tRNA25 NC_002695.1 1940651 1940730 D tRNA-OTHER 1940651..1940730 Escherichia coli O157:H7 str. Sakai 917156 ECs5436 tRNA argO4 NC_002695.1 1940744 1940820 D tRNA-Arg 1940744..1940820 Escherichia coli O157:H7 str. Sakai 917157 ECs5447 tRNA argO5 NC_002695.1 2189515 2189591 R tRNA-Arg complement(2189515..2189591) Escherichia coli O157:H7 str. Sakai 917390 ECs5448 tRNA tRNA99 NC_002695.1 2189605 2189684 R tRNA-OTHER complement(2189605..2189684) Escherichia coli O157:H7 str. Sakai 917397 ECs5449 tRNA ileZ5 NC_002695.1 2189692 2189767 R tRNA-Ile complement(2189692..2189767) Escherichia coli O157:H7 str. Sakai 917392 ECs5453 tRNA argO6 NC_002695.1 2240486 2240562 R tRNA-Arg complement(2240486..2240562) Escherichia coli O157:H7 str. Sakai 917471 ECs5454 tRNA argN4 NC_002695.1 2240576 2240652 R tRNA-Arg complement(2240576..2240652) Escherichia coli O157:H7 str. Sakai 917472 ECs5455 tRNA ileZ6 NC_002695.1 2240660 2240735 R tRNA-Ile complement(2240660..2240735) Escherichia coli O157:H7 str. Sakai 917473 ECs5461 tRNA valV NC_002695.1 2346146 2346222 D tRNA-Val 2346146..2346222 Escherichia coli O157:H7 str. Sakai 913829 ECs5462 tRNA valW NC_002695.1 2346227 2346303 D tRNA-Val 2346227..2346303 Escherichia coli O157:H7 str. Sakai 913653 ECs5466 tRNA leuZ NC_002695.1 2614087 2614173 R tRNA-Leu complement(2614087..2614173) Escherichia coli O157:H7 str. Sakai 915480 ECs5467 tRNA cysT NC_002695.1 2614186 2614259 R tRNA-Cys complement(2614186..2614259) Escherichia coli O157:H7 str. Sakai 912419 ECs5468 tRNA glyW NC_002695.1 2614313 2614388 R tRNA-Gly complement(2614313..2614388) Escherichia coli O157:H7 str. Sakai 912461 ECs5471 tRNA argO7 NC_002695.1 2697756 2697832 R tRNA-Arg complement(2697756..2697832) Escherichia coli O157:H7 str. Sakai 913620 ECs5472 tRNA argN5 NC_002695.1 2697846 2697922 R tRNA-Arg complement(2697846..2697922) Escherichia coli O157:H7 str. Sakai 912593 ECs5473 tRNA ileZ7 NC_002695.1 2697930 2698005 R tRNA-Ile complement(2697930..2698005) Escherichia coli O157:H7 str. Sakai 912469 ECs5474 tRNA serU NC_002695.1 2712036 2712125 R tRNA-Ser complement(2712036..2712125) Escherichia coli O157:H7 str. Sakai 912620 ECs5475 tRNA asnT NC_002695.1 2713117 2713192 D tRNA-Asn 2713117..2713192 Escherichia coli O157:H7 str. Sakai 912299 ECs5476 tRNA asnW NC_002695.1 2727498 2727573 R tRNA-Asn complement(2727498..2727573) Escherichia coli O157:H7 str. Sakai 912947 ECs5477 tRNA asnU NC_002695.1 2729322 2729397 D tRNA-Asn 2729322..2729397 Escherichia coli O157:H7 str. Sakai 912991 ECs5478 tRNA asnV NC_002695.1 2731730 2731805 D tRNA-Asn 2731730..2731805 Escherichia coli O157:H7 str. Sakai 912839 ECs5483 tRNA proL NC_002695.1 3021141 3021217 D tRNA-Pro 3021141..3021217 Escherichia coli O157:H7 str. Sakai 916786 ECs5488 tRNA argW NC_002695.1 3192908 3192982 D tRNA-Arg 3192908..3192982 Escherichia coli O157:H7 str. Sakai 915672 ECs5489 tRNA alaX NC_002695.1 3244824 3244899 R tRNA-Ala complement(3244824..3244899) Escherichia coli O157:H7 str. Sakai 915623 ECs5490 tRNA alaW NC_002695.1 3244939 3245014 R tRNA-Ala complement(3244939..3245014) Escherichia coli O157:H7 str. Sakai 915621 ECs5491 tRNA valU NC_002695.1 3249460 3249535 D tRNA-Val 3249460..3249535 Escherichia coli O157:H7 str. Sakai 915599 ECs5492 tRNA valX NC_002695.1 3249580 3249655 D tRNA-Val 3249580..3249655 Escherichia coli O157:H7 str. Sakai 915597 ECs5493 tRNA valY NC_002695.1 3249702 3249777 D tRNA-Val 3249702..3249777 Escherichia coli O157:H7 str. Sakai 915587 ECs5494 tRNA lysV NC_002695.1 3249782 3249857 D tRNA-Lys 3249782..3249857 Escherichia coli O157:H7 str. Sakai 915585 ECs5501 tRNA gltW NC_002695.1 3449574 3449649 R tRNA-Glu complement(3449574..3449649) Escherichia coli O157:H7 str. Sakai 914868 ECs5504 tRNA ileY NC_002695.1 3507947 3508022 R tRNA-Ile complement(3507947..3508022) Escherichia coli O157:H7 str. Sakai 914767 ECs5505 tRNA argQ NC_002695.1 3541942 3542018 R tRNA-Arg complement(3541942..3542018) Escherichia coli O157:H7 str. Sakai 914730 ECs5506 tRNA argZ NC_002695.1 3542121 3542197 R tRNA-Arg complement(3542121..3542197) Escherichia coli O157:H7 str. Sakai 914729 ECs5507 tRNA argY NC_002695.1 3542260 3542336 R tRNA-Arg complement(3542260..3542336) Escherichia coli O157:H7 str. Sakai 914728 ECs5508 tRNA argV NC_002695.1 3542401 3542477 R tRNA-Arg complement(3542401..3542477) Escherichia coli O157:H7 str. Sakai 914727 ECs5509 tRNA serV NC_002695.1 3542481 3542573 R tRNA-Ser complement(3542481..3542573) Escherichia coli O157:H7 str. Sakai 914726 ECs5512 tRNA metZ NC_002695.1 3669787 3669863 D tRNA-Met 3669787..3669863 Escherichia coli O157:H7 str. Sakai 916518 ECs5513 tRNA metW NC_002695.1 3669897 3669973 D tRNA-Met 3669897..3669973 Escherichia coli O157:H7 str. Sakai 916520 ECs5514 tRNA metV NC_002695.1 3670007 3670083 D tRNA-Met 3670007..3670083 Escherichia coli O157:H7 str. Sakai 916517 ECs5515 tRNA glyU NC_002695.1 3737314 3737387 R tRNA-Gly complement(3737314..3737387) Escherichia coli O157:H7 str. Sakai 916441 ECs5517 tRNA pheV NC_002695.1 3851960 3852035 D tRNA-Phe 3851960..3852035 Escherichia coli O157:H7 str. Sakai 916334 ECs5519 tRNA ileX NC_002695.1 3955129 3955204 D tRNA-Ile 3955129..3955204 Escherichia coli O157:H7 str. Sakai 916222 ECs5521 tRNA metY NC_002695.1 4060711 4060787 R tRNA-Met complement(4060711..4060787) Escherichia coli O157:H7 str. Sakai 916143 ECs5522 tRNA leuU NC_002695.1 4064570 4064656 R tRNA-Leu complement(4064570..4064656) Escherichia coli O157:H7 str. Sakai 916106 ECs5524 tRNA thrV NC_002695.1 4158585 4158660 R tRNA-Thr complement(4158585..4158660) Escherichia coli O157:H7 str. Sakai 916006 ECs5527 tRNA alaU NC_002695.1 4161971 4162046 R tRNA-Ala complement(4161971..4162046) Escherichia coli O157:H7 str. Sakai 916004 ECs5528 tRNA ileU NC_002695.1 4162089 4162165 R tRNA-Ile complement(4162089..4162165) Escherichia coli O157:H7 str. Sakai 916003 ECs5535 tRNA proK NC_002695.1 4450439 4450515 R tRNA-Pro complement(4450439..4450515) Escherichia coli O157:H7 str. Sakai 915711 ECs5538 tRNA selC NC_002695.1 4580769 4580863 D tRNA-Sec 4580769..4580863 Escherichia coli O157:H7 str. Sakai 915506 ECs5544 tRNA gltU NC_002695.1 4736879 4736954 D tRNA-Glu 4736879..4736954 Escherichia coli O157:H7 str. Sakai 915316 ECs5547 tRNA aspT NC_002695.1 4740317 4740392 D tRNA-Asp 4740317..4740392 Escherichia coli O157:H7 str. Sakai 915308 ECs5548 tRNA trpT NC_002695.1 4740401 4740476 D tRNA-Trp 4740401..4740476 Escherichia coli O157:H7 str. Sakai 915307 ECs5550 tRNA argX NC_002695.1 4775781 4775857 D tRNA-Arg 4775781..4775857 Escherichia coli O157:H7 str. Sakai 915221 ECs5551 tRNA hisR NC_002695.1 4775916 4775991 D tRNA-His 4775916..4775991 Escherichia coli O157:H7 str. Sakai 915217 ECs5552 tRNA leuT1 NC_002695.1 4776012 4776098 D tRNA-Leu 4776012..4776098 Escherichia coli O157:H7 str. Sakai 915215 ECs5553 tRNA tRNA51 NC_002695.1 4776142 4776215 D tRNA-OTHER 4776142..4776215 Escherichia coli O157:H7 str. Sakai 915210 ECs5554 tRNA leuT2 NC_002695.1 4776238 4776324 D tRNA-Leu 4776238..4776324 Escherichia coli O157:H7 str. Sakai 915206 ECs5555 tRNA proM2 NC_002695.1 4776367 4776442 D tRNA-Pro 4776367..4776442 Escherichia coli O157:H7 str. Sakai 915198 ECs5558 tRNA ileT NC_002695.1 4833264 4833340 D tRNA-Ile 4833264..4833340 Escherichia coli O157:H7 str. Sakai 915122 ECs5559 tRNA alaT NC_002695.1 4833383 4833458 D tRNA-Ala 4833383..4833458 Escherichia coli O157:H7 str. Sakai 915121 ECs5568 tRNA gltT NC_002695.1 4977554 4977629 D tRNA-Glu 4977554..4977629 Escherichia coli O157:H7 str. Sakai 914970 ECs5571 tRNA thrU NC_002695.1 4984405 4984480 D tRNA-Thr 4984405..4984480 Escherichia coli O157:H7 str. Sakai 916182 ECs5572 tRNA tyrU NC_002695.1 4984489 4984573 D tRNA-Tyr 4984489..4984573 Escherichia coli O157:H7 str. Sakai 914961 ECs5573 tRNA glyT NC_002695.1 4984690 4984764 D tRNA-Gly 4984690..4984764 Escherichia coli O157:H7 str. Sakai 914955 ECs5574 tRNA thrT NC_002695.1 4984771 4984846 D tRNA-Thr 4984771..4984846 Escherichia coli O157:H7 str. Sakai 914957 ECs5577 tRNA gltV NC_002695.1 5018580 5018655 D tRNA-Glu 5018580..5018655 Escherichia coli O157:H7 str. Sakai 914895 ECs5585 tRNA pheU NC_002695.1 5217002 5217077 R tRNA-Phe complement(5217002..5217077) Escherichia coli O157:H7 str. Sakai 914150 ECs5587 tRNA glyV NC_002695.1 5246085 5246160 D tRNA-Gly 5246085..5246160 Escherichia coli O157:H7 str. Sakai 915777 ECs5588 tRNA glyX NC_002695.1 5246197 5246272 D tRNA-Gly 5246197..5246272 Escherichia coli O157:H7 str. Sakai 915780 ECs5589 tRNA glyY NC_002695.1 5246308 5246383 D tRNA-Gly 5246308..5246383 Escherichia coli O157:H7 str. Sakai 914089 ECs5590 tRNA leuX NC_002695.1 5346999 5347083 D tRNA-Leu 5346999..5347083 Escherichia coli O157:H7 str. Sakai 913794 ECs5594 tRNA leuQ NC_002695.1 5464439 5464525 R tRNA-Leu complement(5464439..5464525) Escherichia coli O157:H7 str. Sakai 913559 ECs5366 rRNA rrsH NC_002695.1 227102 228643 D 16S ribosomal RNA 227102..228643 Escherichia coli O157:H7 str. Sakai 913977 ECs5369 rRNA rrlH NC_002695.1 229090 231992 D 23S ribosomal RNA 229090..231992 Escherichia coli O157:H7 str. Sakai 913990 ECs5370 rRNA rrfH NC_002695.1 232085 232204 D 5S ribosomal RNA 232085..232204 Escherichia coli O157:H7 str. Sakai 914016 ECs5499 rRNA rrfG NC_002695.1 3446266 3446385 R 5S ribosomal RNA complement(3446266..3446385) Escherichia coli O157:H7 str. Sakai 914870 ECs5500 rRNA rrlG NC_002695.1 3446478 3449380 R 23S ribosomal RNA complement(3446478..3449380) Escherichia coli O157:H7 str. Sakai 914869 ECs5502 rRNA rrsG NC_002695.1 3449735 3451276 R 16S ribosomal RNA complement(3449735..3451276) Escherichia coli O157:H7 str. Sakai 914867 ECs5523 rRNA rrfF NC_002695.1 4158428 4158547 R 5S ribosomal RNA complement(4158428..4158547) Escherichia coli O157:H7 str. Sakai 916007 ECs5525 rRNA rrfD NC_002695.1 4158673 4158792 R 5S ribosomal RNA complement(4158673..4158792) Escherichia coli O157:H7 str. Sakai 916005 ECs5526 rRNA rrlD NC_002695.1 4158885 4161787 R 23S ribosomal RNA complement(4158885..4161787) Escherichia coli O157:H7 str. Sakai 916000 ECs5529 rRNA rrsD NC_002695.1 4162234 4163775 R 16S ribosomal RNA complement(4162234..4163775) Escherichia coli O157:H7 str. Sakai 916002 ECs5543 rRNA rrsC NC_002695.1 4735252 4736793 D 16S ribosomal RNA 4735252..4736793 Escherichia coli O157:H7 str. Sakai 915361 ECs5545 rRNA rrlC NC_002695.1 4737148 4740052 D 23S ribosomal RNA 4737148..4740052 Escherichia coli O157:H7 str. Sakai 915319 ECs5546 rRNA rrfC NC_002695.1 4740145 4740264 D 5S ribosomal RNA 4740145..4740264 Escherichia coli O157:H7 str. Sakai 915318 ECs5557 rRNA rrsA NC_002695.1 4831654 4833195 D 16S ribosomal RNA 4831654..4833195 Escherichia coli O157:H7 str. Sakai 915123 ECs5560 rRNA rrlA NC_002695.1 4833642 4836546 D 23S ribosomal RNA 4833642..4836546 Escherichia coli O157:H7 str. Sakai 915120 ECs5561 rRNA rrfA NC_002695.1 4836639 4836758 D 5S ribosomal RNA 4836639..4836758 Escherichia coli O157:H7 str. Sakai 915119 ECs5567 rRNA rrsB NC_002695.1 4975927 4977468 D 16S ribosomal RNA 4975927..4977468 Escherichia coli O157:H7 str. Sakai 914974 ECs5569 rRNA rrlB NC_002695.1 4977823 4980727 D 23S ribosomal RNA 4977823..4980727 Escherichia coli O157:H7 str. Sakai 914971 ECs5570 rRNA rrfB NC_002695.1 4980820 4980939 D 5S ribosomal RNA 4980820..4980939 Escherichia coli O157:H7 str. Sakai 914963 ECs5576 rRNA rrsE NC_002695.1 5016953 5018494 D 16S ribosomal RNA 5016953..5018494 Escherichia coli O157:H7 str. Sakai 914854 ECs5578 rRNA rrlE NC_002695.1 5018849 5021753 D 23S ribosomal RNA 5018849..5021753 Escherichia coli O157:H7 str. Sakai 915231 ECs5579 rRNA rrfE NC_002695.1 5021846 5021965 D 5S ribosomal RNA 5021846..5021965 Escherichia coli O157:H7 str. Sakai 916175