-- dump date 20140619_085910 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_052604.1 10955263 1789662 413..736 1 NC_002127.1 plasmid mobilization 736 mobA 1789662 mobA Escherichia coli O157:H7 str. Sakai plasmid mobilization NP_052604.1 413 D 386585 CDS NP_052605.1 10955264 1789661 complement(971..1351) 1 NC_002127.1 hypothetical protein 1351 1789661 pOSAK1_02 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052605.1 971 R 386585 CDS NP_052606.1 10955265 1789663 complement(1348..2388) 1 NC_002127.1 hypothetical protein 2388 1789663 pOSAK1_03 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052606.1 1348 R 386585 CDS NP_052607.1 10955349 1789672 join(92527..92721,1..2502) 1 NC_002128.1 ToxR-regulated lipoprotein 2502 tagA 1789672 tagA Escherichia coli O157:H7 str. Sakai ToxR-regulated lipoprotein NP_052607.1 92527 D 386585 CDS NP_052608.1 10955267 1789731 2589..3464 1 NC_002128.1 type II secretion pathway related protein; EtpC 3464 etpC 1789731 etpC Escherichia coli O157:H7 str. Sakai EtpC NP_052608.1 2589 D 386585 CDS NP_052609.1 10955268 1789733 3675..5432 1 NC_002128.1 type II secretion pathway related protein; EtpD 5432 etpD 1789733 etpD Escherichia coli O157:H7 str. Sakai EtpD NP_052609.1 3675 D 386585 CDS NP_052610.1 10955269 1789725 5432..6937 1 NC_002128.1 type II secretion pathway related protein; EtpE 6937 etpE 1789725 etpE Escherichia coli O157:H7 str. Sakai EtpE NP_052610.1 5432 D 386585 CDS NP_052611.1 10955270 1789729 6939..8162 1 NC_002128.1 type II secretion pathway related protein; EtpF 8162 etpF 1789729 etpF Escherichia coli O157:H7 str. Sakai EtpF NP_052611.1 6939 D 386585 CDS NP_052612.1 10955271 1789711 8193..8627 1 NC_002128.1 type II secretion pathway related protein; EtpG 8627 etpG 1789711 etpG Escherichia coli O157:H7 str. Sakai EtpG NP_052612.1 8193 D 386585 CDS NP_052613.1 10955272 1789742 8624..9178 1 NC_002128.1 type II secretion pathway related protein; EtpH 9178 etpH 1789742 etpH Escherichia coli O157:H7 str. Sakai EtpH NP_052613.1 8624 D 386585 CDS NP_052614.1 10955273 1789681 9193..9540 1 NC_002128.1 type II secretion pathway related protein; EtpI 9540 etpI 1789681 etpI Escherichia coli O157:H7 str. Sakai EtpI NP_052614.1 9193 D 386585 CDS NP_052615.1 10955274 1789730 9537..10136 1 NC_002128.1 type II secretion pathway related protein; EptJ 10136 etpJ 1789730 etpJ Escherichia coli O157:H7 str. Sakai EptJ NP_052615.1 9537 D 386585 CDS NP_052616.1 10955275 1789734 10133..11110 1 NC_002128.1 type II secretion pathway related protein; EtpK 11110 etpK 1789734 etpK Escherichia coli O157:H7 str. Sakai EtpK NP_052616.1 10133 D 386585 CDS NP_052617.1 10955276 1789704 11473..12321 1 NC_002128.1 type II secretion pathway related protein; EtpL 12321 etpL 1789704 etpL Escherichia coli O157:H7 str. Sakai EtpL NP_052617.1 11473 D 386585 CDS NP_052618.1 10955277 1789716 12308..12820 1 NC_002128.1 type II secretion pathway related protein; EtpM 12820 etpM 1789716 etpM Escherichia coli O157:H7 str. Sakai EtpM NP_052618.1 12308 D 386585 CDS NP_052619.1 10955278 1789664 12995..13711 1 NC_002128.1 type II secretion pathway related protein; EptN 13711 etpN 1789664 etpN Escherichia coli O157:H7 str. Sakai EptN NP_052619.1 12995 D 386585 CDS NP_052620.1 10955279 1789743 13803..14204 1 NC_002128.1 type II secretion pathway related protein; EptO 14204 etpO 1789743 etpO Escherichia coli O157:H7 str. Sakai EptO NP_052620.1 13803 D 386585 CDS NP_052621.1 10955280 1789717 14347..14688 1 NC_002128.1 hypothetical 12.7 kDa protein encoded in insertion element IS911; similar to SwissProt accession number P39213; hypothetical protein 14688 1789717 pO157p15 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052621.1 14347 D 386585 CDS NP_052622.1 10955281 1789706 14733..15554 1 NC_002128.1 similar to PIR accession number S56510; hypothetical protein 15554 1789706 pO157p16 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052622.1 14733 D 386585 CDS NP_052623.1 10955282 1789689 16119..16610 1 NC_002128.1 hemolysin C 16610 hlyC 1789689 hlyC Escherichia coli O157:H7 str. Sakai hemolysin C NP_052623.1 16119 D 386585 CDS NP_052624.1 10955283 1789686 16612..19608 1 NC_002128.1 hemolysin A 19608 hlyA 1789686 hlyA Escherichia coli O157:H7 str. Sakai hemolysin A NP_052624.1 16612 D 386585 CDS NP_052625.1 10955284 1789727 19658..21778 1 NC_002128.1 hemolysin B 21778 hlyB 1789727 hlyB Escherichia coli O157:H7 str. Sakai hemolysin B NP_052625.1 19658 D 386585 CDS NP_052626.1 10955285 1789705 21782..23221 1 NC_002128.1 hemolysin D 23221 hlyD 1789705 hlyD Escherichia coli O157:H7 str. Sakai hemolysin D NP_052626.1 21782 D 386585 CDS NP_958720.1 41223294 2717077 23288..23482 1 NC_002128.1 hypothetical protein 23482 2717077 ECp021.1n Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958720.1 23288 D 386585 CDS NP_052627.1 10955286 1789696 23512..23796 1 NC_002128.1 similar to SwissProt accession number P42193; PapX 23796 papX 1789696 papX Escherichia coli O157:H7 str. Sakai PapX NP_052627.1 23512 D 386585 CDS NP_958721.1 41223295 2717075 23965..24195 1 NC_002128.1 hypothetical protein 24195 2717075 ECp023 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958721.1 23965 D 386585 CDS NP_052628.1 10955287 1789708 24316..25056 1 NC_002128.1 probable site-specific recombinase in AFA region; similar to SwissProt accession number Q47036; recombinase 25056 1789708 pO157p22 Escherichia coli O157:H7 str. Sakai recombinase NP_052628.1 24316 D 386585 CDS NP_052629.1 10955288 1789668 complement(24745..25062) 1 NC_002128.1 hypothetical protein 25062 1789668 pO157p23 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052629.1 24745 R 386585 CDS NP_052630.2 41223296 1789691 complement(25341..26318) 1 NC_002128.1 replication protein RepFIB (P307 replicon); similar to PIR accession number A32310; RepFIB 26318 repFIB 1789691 repFIB Escherichia coli O157:H7 str. Sakai RepFIB NP_052630.2 25341 R 386585 CDS NP_052631.1 10955290 1789679 26056..26385 1 NC_002128.1 hypothetical protein 26385 1789679 pO157p25 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052631.1 26056 D 386585 CDS NP_958722.1 41223297 2717076 complement(26726..26926) 1 NC_002128.1 hypothetical protein 26926 2717076 ECp025.2n Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958722.1 26726 R 386585 CDS NP_052632.1 10955291 1789739 complement(26923..27543) 1 NC_002128.1 hypothetical protein 27543 1789739 pO157p26 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052632.1 26923 R 386585 CDS NP_052633.1 10955292 1789712 complement(27540..28223) 1 NC_002128.1 KfrAs 28223 1789712 pO157p27 Escherichia coli O157:H7 str. Sakai KfrAs NP_052633.1 27540 R 386585 CDS NP_052634.1 10955293 1789714 28682..28900 1 NC_002128.1 CcdA protein; protein H; LynA; similar to SwissProt accession number P05702; plasmid maintenance protein CcdA 28900 letA 1789714 letA Escherichia coli O157:H7 str. Sakai plasmid maintenance protein CcdA NP_052634.1 28682 D 386585 CDS NP_052635.1 10955294 1789728 28902..29207 1 NC_002128.1 cytotoxic protein; controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 29207 letB 1789728 letB Escherichia coli O157:H7 str. Sakai plasmid maintenance protein CcdB NP_052635.1 28902 D 386585 CDS NP_052636.1 10955295 1789694 29208..30014 1 NC_002128.1 Protein D; similar to SwissProt accession number P06615; resolvase 30014 1789694 pO157p30 Escherichia coli O157:H7 str. Sakai resolvase NP_052636.1 29208 D 386585 CDS NP_052637.1 10955296 1789677 complement(30736..31626) 1 NC_002128.1 similar to SwissProt accession number P16942; transposase encoded in insertion sequence IS629; transposase 31626 1789677 pO157p31 Escherichia coli O157:H7 str. Sakai transposase NP_052637.1 30736 R 386585 CDS NP_052638.1 10955297 3399562 complement(31623..31949) 1 NC_002128.1 hypothetical 12 kDa protein encoded in insertion sequence IS629; similar to SwissProt accession number P16941; hypothetical protein 31949 3399562 pO157p83 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052638.1 31623 R 386585 CDS NP_052640.1 10955299 1789690 32837..34003 1 NC_002128.1 Protein A; similar to SwissProt accession number P08866; plasmid-partitioning protein SopA 34003 sopA 1789690 sopA Escherichia coli O157:H7 str. Sakai plasmid-partitioning protein SopA NP_052640.1 32837 D 386585 CDS NP_052641.1 10955300 1789685 34003..34974 1 NC_002128.1 SopB; plasmid-partitioning protein 34974 sopB 1789685 sopB Escherichia coli O157:H7 str. Sakai plasmid-partitioning protein NP_052641.1 34003 D 386585 CDS NP_052642.1 10955301 1789698 36274..37998 1 NC_002128.1 similar to SwissProt accession number P19593; reverse transcriptase 37998 1789698 pO157p35 Escherichia coli O157:H7 str. Sakai reverse transcriptase NP_052642.1 36274 D 386585 CDS NP_052643.1 10955302 1789718 38075..38977 1 NC_002128.1 hypothetical protein 38977 1789718 pO157p36 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052643.1 38075 D 386585 CDS NP_052644.1 10955303 1789693 38981..39286 1 NC_002128.1 hypothetical protein 39286 1789693 pO157p37 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052644.1 38981 D 386585 CDS NP_052645.1 10955304 1789670 39363..40046 1 NC_002128.1 similar to PIR accession number S18997; putative methylase 40046 1789670 pO157p38 Escherichia coli O157:H7 str. Sakai putative methylase NP_052645.1 39363 D 386585 CDS NP_958723.1 41223298 2717073 40047..40268 1 NC_002128.1 hypothetical protein 40268 2717073 ECp042 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958723.1 40047 D 386585 CDS NP_052646.1 10955305 1789700 40162..40716 1 NC_002128.1 hypothetical protein 40716 1789700 pO157p39 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052646.1 40162 D 386585 CDS NP_052647.1 10955306 1789709 40762..41538 1 NC_002128.1 hypothetical protein 41538 1789709 pO157p40 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052647.1 40762 D 386585 CDS NP_052648.1 10955307 1789736 41411..41983 1 NC_002128.1 hypothetical protein 41983 1789736 pO157p41 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052648.1 41411 D 386585 CDS NP_052649.1 10955308 1789678 42079..42381 1 NC_002128.1 antirestriction protein; similar to SwissProt accession number P52603; hypothetical protein 42381 klcA 1789678 klcA Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052649.1 42079 D 386585 CDS NP_052650.1 10955309 1789683 42428..42850 1 NC_002128.1 hypothetical protein 42850 1789683 pO157p43 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052650.1 42428 D 386585 CDS NP_052651.1 10955310 1789726 43157..43546 1 NC_002128.1 hypothetical protein 43546 1789726 pO157p44 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052651.1 43157 D 386585 CDS NP_052652.1 10955311 1789665 44034..44264 1 NC_002128.1 hypothetical protein 44264 1789665 pO157p45 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052652.1 44034 D 386585 CDS NP_052653.1 10955312 1789741 44316..45677 1 NC_002128.1 hypothetical protein 45677 1789741 pO157p46 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052653.1 44316 D 386585 CDS NP_052654.1 10955313 1789684 45724..46287 1 NC_002128.1 hypothetical protein 46287 1789684 pO157p47 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052654.1 45724 D 386585 CDS NP_052655.1 10955314 1789721 complement(46373..46828) 1 NC_002128.1 hypothetical protein 46828 1789721 pO157p48 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052655.1 46373 R 386585 CDS NP_052656.1 10955315 1789738 47130..47582 1 NC_002128.1 similar to SwissProt accession number P18310; helix-destabilizing protein; single-stranded DNA-binding protein 47582 ssb 1789738 ssb Escherichia coli O157:H7 str. Sakai single-stranded DNA-binding protein NP_052656.1 47130 D 386585 CDS NP_958724.1 41223299 2717072 47639..47872 1 NC_002128.1 hypothetical protein 47872 2717072 ECp054 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958724.1 47639 D 386585 CDS NP_052657.1 10955316 1789702 47938..49896 1 NC_002128.1 hypothetical protein 49896 1789702 pO157p50 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052657.1 47938 D 386585 CDS NP_052658.1 10955317 1789688 49951..50385 1 NC_002128.1 responsible for plasmid SOS inhibition; similar to PIR accession number S01898; plasmid SOS inhibition protein B 50385 psiB 1789688 psiB Escherichia coli O157:H7 str. Sakai plasmid SOS inhibition protein B NP_052658.1 49951 D 386585 CDS NP_052659.1 10955318 1789722 50382..51143 1 NC_002128.1 PsiA; plasmid SOS inhibition protein A 51143 psiA 1789722 psiA Escherichia coli O157:H7 str. Sakai plasmid SOS inhibition protein A NP_052659.1 50382 D 386585 CDS NP_052660.1 10955319 1789673 51375..51533 1 NC_002128.1 F leading maintenance protein; similar to SwissProt accession number P16077; small toxic polypeptide 51533 parB 1789673 parB Escherichia coli O157:H7 str. Sakai small toxic polypeptide NP_052660.1 51375 D 386585 CDS NP_052661.1 10955320 1789737 51715..53688 1 NC_002128.1 similar to PIR accession number B38529; NikB 53688 nikB 1789737 nikB Escherichia coli O157:H7 str. Sakai NikB NP_052661.1 51715 D 386585 CDS NP_052662.1 10955321 1789666 53756..54187 1 NC_002128.1 hypothetical protein 54187 1789666 pO157p55 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052662.1 53756 D 386585 CDS NP_052663.1 10955322 1789692 complement(54761..55120) 1 NC_002128.1 encoded in insertion sequence IS3; transposase Tra5 55120 1789692 pO157p56 Escherichia coli O157:H7 str. Sakai transposase Tra5 NP_052663.1 54761 R 386585 CDS NP_052664.1 10955323 1789710 55302..55712 1 NC_002128.1 encoded in insertion sequence element IS21; similar to SwissProt accession number P15025; transposase 55712 1789710 pO157p57 Escherichia coli O157:H7 str. Sakai transposase NP_052664.1 55302 D 386585 CDS NP_052665.1 10955324 1789667 55981..65490 1 NC_002128.1 similar to SwissProt accession number P18177; toxin B 65490 toxB 1789667 toxB Escherichia coli O157:H7 str. Sakai toxin B NP_052665.1 55981 D 386585 CDS NP_052666.1 10955325 1789744 65582..65854 1 NC_002128.1 encoded in insertion sequence IS3; transposase Tra5 65854 1789744 pO157p59 Escherichia coli O157:H7 str. Sakai transposase Tra5 NP_052666.1 65582 D 386585 CDS NP_052667.1 10955326 1789703 complement(65781..66284) 1 NC_002128.1 similar to SwissProt accession number P16941; hypothetical protein 66284 IS629 1789703 IS629 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052667.1 65781 R 386585 CDS NP_052669.1 10955328 1789740 67749..68495 1 NC_002128.1 similar to SwissProt accession number P22710; conjugal transfer pilus acetylation protein TraX 68495 traX 1789740 traX Escherichia coli O157:H7 str. Sakai conjugal transfer pilus acetylation protein TraX NP_052669.1 67749 D 386585 CDS NP_052670.1 10955329 1789674 68554..69414 1 NC_002128.1 similar to SwissProt accession number Q99390; hypothetical protein 69414 1789674 pO157p63 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052670.1 68554 D 386585 CDS NP_052671.1 10955330 1789697 69517..70077 1 NC_002128.1 conjugal transfer repressor; similar to SwissProt accession number P08315; conjugal transfer fertility inhibition protein FinO 70077 finO 1789697 finO Escherichia coli O157:H7 str. Sakai conjugal transfer fertility inhibition protein FinO NP_052671.1 69517 D 386585 CDS NP_958725.1 41223300 2717079 70210..70422 1 NC_002128.1 hypothetical protein 70422 2717079 ECp070 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958725.1 70210 D 386585 CDS NP_052672.1 10955331 1789676 70667..71128 1 NC_002128.1 similar to SwissProt accession number Q99342; hypothetical protein 71128 1789676 pO157p65 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052672.1 70667 D 386585 CDS NP_958726.1 41223301 2717074 71174..71383 1 NC_002128.1 hypothetical protein 71383 2717074 ECp072 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958726.1 71174 D 386585 CDS NP_052673.1 10955332 1789675 71421..71759 1 NC_002128.1 similar to PIR accession number S28661; hypothetical protein 71759 1789675 pO157p66 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052673.1 71421 D 386585 CDS NP_052674.1 10955333 1789682 71999..72253 1 NC_002128.1 similar to SwissProt accession number P03847; replication protein 72253 repA2 1789682 repA2 Escherichia coli O157:H7 str. Sakai replication protein NP_052674.1 71999 D 386585 CDS NP_052675.1 10955334 1789669 72556..73413 1 NC_002128.1 RepA; replication protein 73413 repA1 1789669 repA1 Escherichia coli O157:H7 str. Sakai replication protein NP_052675.1 72556 D 386585 CDS NP_052676.1 10955335 1789719 74325..74609 1 NC_002128.1 hypothetical protein 74609 1789719 pO157p69 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052676.1 74325 D 386585 CDS NP_052677.1 10955336 1789745 74609..74884 1 NC_002128.1 hypothetical protein 74884 1789745 pO157p70 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052677.1 74609 D 386585 CDS NP_052678.1 10955337 1789723 74979..75185 1 NC_002128.1 stability (stb) locus of IncFII plasmid NR1; similar to SwissProt accession number P11907; hypothetical protein 75185 1789723 pO157p71 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052678.1 74979 D 386585 CDS NP_052681.1 10955340 1789699 complement(76062..76526) 1 NC_002128.1 encoded in insertion sequence IS91; similar to PIR accession number S23782; transposase 76526 1789699 pO157p74 Escherichia coli O157:H7 str. Sakai transposase NP_052681.1 76062 R 386585 CDS NP_052684.1 10955343 1789701 79689..80576 1 NC_002128.1 encoded in insertion sequence IS629; similar to SwissProt accession number P16942; transposase 80576 1789701 pO157p77 Escherichia coli O157:H7 str. Sakai transposase NP_052684.1 79689 D 386585 CDS NP_052685.1 10955344 1789732 80757..84659 1 NC_002128.1 extracellular serine protease; EspP 84659 espP 1789732 espP Escherichia coli O157:H7 str. Sakai EspP NP_052685.1 80757 D 386585 CDS NP_958727.1 41223302 2717078 complement(85124..85396) 1 NC_002128.1 hypothetical protein 85396 2717078 ECp088.2c Escherichia coli O157:H7 str. Sakai hypothetical protein NP_958727.1 85124 R 386585 CDS NP_052686.1 10955345 1789680 87222..87659 1 NC_002128.1 hypothetical protein 87659 1789680 pO157p79 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052686.1 87222 D 386585 CDS NP_052687.1 10955346 1789671 87659..88765 1 NC_002128.1 RfbU-like protein 88765 1789671 pO157p80 Escherichia coli O157:H7 str. Sakai RfbU-like protein NP_052687.1 87659 D 386585 CDS NP_052688.1 10955347 1789713 88855..90576 1 NC_002128.1 similar to SwissProt accession number P32678; hypothetical protein 90576 1789713 pO157p81 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_052688.1 88855 D 386585 CDS NP_052689.1 10955348 1789687 90650..91648 1 NC_002128.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 91648 1789687 pO157p82 Escherichia coli O157:H7 str. Sakai lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase NP_052689.1 90650 D 386585 CDS NP_308028.1 15829255 913387 190..273 1 NC_002695.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 273 thrL 913387 thrL Escherichia coli O157:H7 str. Sakai thr operon leader peptide NP_308028.1 190 D 386585 CDS NP_308029.1 15829256 913388 354..2816 1 NC_002695.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2816 thrA 913388 thrA Escherichia coli O157:H7 str. Sakai bifunctional aspartokinase I/homoserine dehydrogenase I NP_308029.1 354 D 386585 CDS NP_308030.1 15829257 913390 2818..3750 1 NC_002695.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3750 913390 ECs0003 Escherichia coli O157:H7 str. Sakai homoserine kinase NP_308030.1 2818 D 386585 CDS NP_308031.1 15829258 913393 3751..5037 1 NC_002695.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5037 913393 ECs0004 Escherichia coli O157:H7 str. Sakai threonine synthase NP_308031.1 3751 D 386585 CDS NP_308032.1 15829259 913394 5251..5547 1 NC_002695.1 similar to B0005_ECOLI gi|1786186 (conserved in Escherichia coli K-12); hypothetical protein 5547 913394 ECs0005 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308032.1 5251 D 386585 CDS NP_308033.1 15829260 913395 complement(5700..6476) 1 NC_002695.1 similar to YAAA_ECOLI gi|1786187 (conserved in Escherichia coli K-12); hypothetical protein 6476 913395 ECs0006 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308033.1 5700 R 386585 CDS NP_308034.1 15829261 913398 complement(6546..7976) 1 NC_002695.1 similar to YAAJ_ECOLI gi|1786188 (conserved in Escherichia coli K-12); inner membrane transport protein 7976 913398 ECs0007 Escherichia coli O157:H7 str. Sakai inner membrane transport protein NP_308034.1 6546 R 386585 CDS NP_308035.1 15829262 913400 8255..9208 1 NC_002695.1 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 9208 913400 ECs0008 Escherichia coli O157:H7 str. Sakai transaldolase B NP_308035.1 8255 D 386585 CDS NP_308036.1 15829263 913401 9323..9910 1 NC_002695.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9910 mogA 913401 mogA Escherichia coli O157:H7 str. Sakai molybdenum cofactor biosynthesis protein MogA NP_308036.1 9323 D 386585 CDS NP_308037.1 15829264 913402 complement(9945..10511) 1 NC_002695.1 similar to YAAH_ECOLI gi|1786191 (conserved in Escherichia coli K-12); hypothetical protein 10511 913402 ECs0010 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308037.1 9945 R 386585 CDS NP_308038.1 15829265 913403 complement(10660..11373) 1 NC_002695.1 similar to B0011_ECOLI gi|1786193 (conserved in Escherichia coli K-12); hypothetical protein 11373 913403 ECs0012 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308038.1 10660 R 386585 CDS NP_308040.1 15829267 913405 complement(11399..11803) 1 NC_002695.1 similar to YAAI_ECOLI gi|1786195 (conserved in Escherichia coli K-12); hypothetical protein 11803 913405 ECs0013 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308040.1 11399 R 386585 CDS NP_308041.1 15829268 913406 12180..14096 1 NC_002695.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14096 dnaK 913406 dnaK Escherichia coli O157:H7 str. Sakai molecular chaperone DnaK NP_308041.1 12180 D 386585 CDS NP_308042.1 15829269 913407 14185..15315 1 NC_002695.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 15315 913407 ECs0015 Escherichia coli O157:H7 str. Sakai molecular chaperone DnaJ NP_308042.1 14185 D 386585 CDS NP_308043.1 15829270 913408 complement(15419..15628) 1 NC_002695.1 similar to GEF_ECOLI gi|1786200 (conserved in Escherichia coli K-12); Gef protein 15628 913408 ECs0016 Escherichia coli O157:H7 str. Sakai Gef protein NP_308043.1 15419 R 386585 CDS NP_308044.1 15829271 913409 16157..17323 1 NC_002695.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17323 nhaA 913409 nhaA Escherichia coli O157:H7 str. Sakai pH-dependent sodium/proton antiporter NP_308044.1 16157 D 386585 CDS NP_308045.1 15829272 913410 17383..18288 1 NC_002695.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18288 nhaR 913410 nhaR Escherichia coli O157:H7 str. Sakai transcriptional activator NhaR NP_308045.1 17383 D 386585 CDS NP_308046.1 15829273 913413 complement(18326..18853) 1 NC_002695.1 hypothetical protein 18853 913413 ECs0019 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308046.1 18326 R 386585 CDS NP_308048.1 15829275 913415 complement(18959..19285) 1 NC_002695.1 hypothetical protein 19285 913415 ECs0021 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308048.1 18959 R 386585 CDS NP_308049.1 15829276 913416 complement(19298..21748) 1 NC_002695.1 similar to outer membrane usher protein precursors e.g. YehB [Escherichia coli K-12] gi|465572|sp|P33341|YEHB_ECOLI; outer membrane usher protein 21748 913416 ECs0022 Escherichia coli O157:H7 str. Sakai outer membrane usher protein NP_308049.1 19298 R 386585 CDS NP_308050.1 15829277 913417 complement(21761..22444) 1 NC_002695.1 similar to fimbrial chaperones e.g. YehC [Escherichia coli] gi|465573|sp|P33342|YEHC_ECOLI; fimbrial chaperone 22444 913417 ECs0023 Escherichia coli O157:H7 str. Sakai fimbrial chaperone NP_308050.1 21761 R 386585 CDS NP_308051.1 15829278 913418 complement(22494..23027) 1 NC_002695.1 similar to YehD [Escherichia coli] gi|465574|sp|P33343|YEHD_ECOLI, long polar fimbrial major protein [Salmonella typhimurium] gi|1170815|sp|P43660|LPFA_SALT; fimbrial protein 23027 913418 ECs0024 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_308051.1 22494 R 386585 CDS NP_308052.1 15829279 913419 complement(23329..24750) 1 NC_002695.1 hypothetical protein 24750 913419 ECs0025 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308052.1 23329 R 386585 CDS NP_308053.1 15829280 913420 complement(25220..25483) 1 NC_002695.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 25483 rpsT 913420 rpsT Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S20 NP_308053.1 25220 R 386585 CDS NP_308054.1 15829281 913422 25586..25810 1 NC_002695.1 similar to B0024_ECOLI gi|1786207 (conserved in Escherichia coli K-12); hypothetical protein 25810 913422 ECs0027 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308054.1 25586 D 386585 CDS NP_308055.1 15829282 913423 25818..26759 1 NC_002695.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 26759 913423 ECs0028 Escherichia coli O157:H7 str. Sakai bifunctional riboflavin kinase/FMN adenylyltransferase NP_308055.1 25818 D 386585 CDS NP_308056.1 15829283 913425 26802..29618 1 NC_002695.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 29618 ileS 913425 ileS Escherichia coli O157:H7 str. Sakai isoleucyl-tRNA synthetase NP_308056.1 26802 D 386585 CDS NP_308057.1 15829284 913426 29618..30112 1 NC_002695.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 30112 lspA 913426 lspA Escherichia coli O157:H7 str. Sakai lipoprotein signal peptidase NP_308057.1 29618 D 386585 CDS NP_308058.1 15829285 913427 30200..30649 1 NC_002695.1 similar to SLPA_ECOLI gi|1786211 (conserved in Escherichia coli K-12); FKBP-type peptidyl-prolyl cis-trans isomerase 30649 913427 ECs0031 Escherichia coli O157:H7 str. Sakai FKBP-type peptidyl-prolyl cis-trans isomerase NP_308058.1 30200 D 386585 CDS NP_308059.1 15829286 913428 30651..31601 1 NC_002695.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 31601 ispH 913428 ispH Escherichia coli O157:H7 str. Sakai 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_308059.1 30651 D 386585 CDS NP_308060.1 15829287 913429 31667..32581 1 NC_002695.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 32581 913429 ECs0033 Escherichia coli O157:H7 str. Sakai ribonucleoside hydrolase RihC NP_308060.1 31667 D 386585 CDS NP_308061.1 15829288 913430 32748..33569 1 NC_002695.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 33569 913430 ECs0034 Escherichia coli O157:H7 str. Sakai dihydrodipicolinate reductase NP_308061.1 32748 D 386585 CDS NP_308062.1 15829289 913431 34025..35173 1 NC_002695.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 35173 913431 ECs0035 Escherichia coli O157:H7 str. Sakai carbamoyl phosphate synthase small subunit NP_308062.1 34025 D 386585 CDS NP_308063.1 15829290 913432 35191..38412 1 NC_002695.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 38412 carB 913432 carB Escherichia coli O157:H7 str. Sakai carbamoyl phosphate synthase large subunit NP_308063.1 35191 D 386585 CDS NP_944498.1 38704266 2693794 complement(38420..38638) 1 NC_002695.1 hypothetical protein 38638 2693794 ECs5362 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944498.1 38420 R 386585 CDS NP_308064.2 162139821 913433 38673..39068 1 NC_002695.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; CaiF family transcriptional regulator 39068 913433 ECs0037 Escherichia coli O157:H7 str. Sakai CaiF family transcriptional regulator NP_308064.2 38673 D 386585 CDS NP_308065.1 15829292 913434 complement(39187..39798) 1 NC_002695.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 39798 913434 ECs0038 Escherichia coli O157:H7 str. Sakai carnitine operon protein CaiE NP_308065.1 39187 R 386585 CDS NP_308066.2 229544783 913435 complement(39783..40568) 1 NC_002695.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 40568 913435 ECs0039 Escherichia coli O157:H7 str. Sakai carnitinyl-CoA dehydratase NP_308066.2 39783 R 386585 CDS NP_308067.1 15829294 913437 complement(40677..42245) 1 NC_002695.1 similar to CAIC_ECOLI gi|1786221 (conserved in Escherichia coli K-12); crotonobetaine/carnitine-CoA ligase 42245 caiC 913437 caiC Escherichia coli O157:H7 str. Sakai crotonobetaine/carnitine-CoA ligase NP_308067.1 40677 R 386585 CDS NP_308068.1 15829295 913438 complement(42304..43521) 1 NC_002695.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 43521 913438 ECs0041 Escherichia coli O157:H7 str. Sakai crotonobetainyl-CoA:carnitine CoA-transferase NP_308068.1 42304 R 386585 CDS NP_308069.1 15829296 913439 complement(43650..44792) 1 NC_002695.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 44792 913439 ECs0042 Escherichia coli O157:H7 str. Sakai crotonobetainyl-CoA dehydrogenase NP_308069.1 43650 R 386585 CDS NP_308070.1 15829297 913440 complement(44823..46337) 1 NC_002695.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 46337 913440 ECs0043 Escherichia coli O157:H7 str. Sakai L-carnitine/gamma-butyrobetaine antiporter NP_308070.1 44823 R 386585 CDS NP_308071.2 162139820 913441 46816..47586 1 NC_002695.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 47586 913441 ECs0044 Escherichia coli O157:H7 str. Sakai electron transfer flavoprotein FixA NP_308071.2 46816 D 386585 CDS NP_308072.1 15829299 913442 47601..48542 1 NC_002695.1 involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 48542 fixB 913442 fixB Escherichia coli O157:H7 str. Sakai electron transfer flavoprotein FixB NP_308072.1 47601 D 386585 CDS NP_308073.1 15829300 913445 48593..49879 1 NC_002695.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 49879 913445 ECs0046 Escherichia coli O157:H7 str. Sakai oxidoreductase FixC NP_308073.1 48593 D 386585 CDS NP_308074.1 15829301 913446 49876..50163 1 NC_002695.1 similar to FIXX_ECOLI gi|1786228 (conserved in Escherichia coli K-12); ferredoxin 50163 913446 ECs0047 Escherichia coli O157:H7 str. Sakai ferredoxin NP_308074.1 49876 D 386585 CDS NP_308075.1 15829302 913447 50221..51552 1 NC_002695.1 similar to YAAU_ECOLI gi|1786229 (conserved in Escherichia coli K-12); transporter 51552 913447 ECs0048 Escherichia coli O157:H7 str. Sakai transporter NP_308075.1 50221 D 386585 CDS NP_308076.1 15829303 913448 51660..52190 1 NC_002695.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 52190 913448 ECs0049 Escherichia coli O157:H7 str. Sakai glutathione-regulated potassium-efflux system ancillary protein KefF NP_308076.1 51660 D 386585 CDS NP_308077.1 15829304 913449 52183..54045 1 NC_002695.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 54045 913449 ECs0050 Escherichia coli O157:H7 str. Sakai glutathione-regulated potassium-efflux system protein KefC NP_308077.1 52183 D 386585 CDS NP_308078.1 15829305 913450 54237..54716 1 NC_002695.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 54716 folA 913450 folA Escherichia coli O157:H7 str. Sakai dihydrofolate reductase NP_308078.1 54237 D 386585 CDS NP_308079.1 15829306 913451 54802..55035 1 NC_002695.1 similar to CcdA protein (LetA protein) of F plasmid [Escherichia coli] gi|9507755|ref|NP_061421.1; CcdA-like protein 55035 913451 ECs0052 Escherichia coli O157:H7 str. Sakai CcdA-like protein NP_308079.1 54802 D 386585 CDS NP_308080.1 15829307 913452 55038..55352 1 NC_002695.1 similar to CcdB protein (LetB protein) of plasmid F [Escherichia coli] gi|9507756|ref|NP_061422.1; CcdB-like protein 55352 913452 ECs0053 Escherichia coli O157:H7 str. Sakai CcdB-like protein NP_308080.1 55038 D 386585 CDS NP_308081.1 15829308 913453 complement(55349..56197) 1 NC_002695.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 56197 apaH 913453 apaH Escherichia coli O157:H7 str. Sakai diadenosine tetraphosphatase NP_308081.1 55349 R 386585 CDS NP_308082.1 15829309 913454 complement(56204..56581) 1 NC_002695.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 56581 apaG 913454 apaG Escherichia coli O157:H7 str. Sakai ApaG protein NP_308082.1 56204 R 386585 CDS NP_308083.1 15829310 913455 complement(56584..57405) 1 NC_002695.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 57405 ksgA 913455 ksgA Escherichia coli O157:H7 str. Sakai dimethyladenosine transferase NP_308083.1 56584 R 386585 CDS NP_308084.1 15829311 913457 complement(57402..58391) 1 NC_002695.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 58391 pdxA 913457 pdxA Escherichia coli O157:H7 str. Sakai 4-hydroxythreonine-4-phosphate dehydrogenase NP_308084.1 57402 R 386585 CDS NP_308085.1 15829312 913458 complement(58391..59677) 1 NC_002695.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 59677 913458 ECs0058 Escherichia coli O157:H7 str. Sakai peptidyl-prolyl cis-trans isomerase SurA NP_308085.1 58391 R 386585 CDS NP_308086.1 15829313 913459 complement(59730..62084) 1 NC_002695.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 62084 913459 ECs0059 Escherichia coli O157:H7 str. Sakai organic solvent tolerance protein NP_308086.1 59730 R 386585 CDS NP_308087.1 15829314 913460 62339..63154 1 NC_002695.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 63154 djlA 913460 djlA Escherichia coli O157:H7 str. Sakai Dna-J like membrane chaperone protein NP_308087.1 62339 D 386585 CDS NP_308088.1 15829315 913461 63449..64201 1 NC_002695.1 similar to YABP_ECOLI gi|1786242 (conserved in Escherichia coli K-12); hypothetical protein 64201 913461 ECs0061 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308088.1 63449 D 386585 CDS NP_308089.1 15829316 913462 complement(64619..65278) 1 NC_002695.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 65278 913462 ECs0062 Escherichia coli O157:H7 str. Sakai 23S rRNA/tRNA pseudouridine synthase A NP_308089.1 64619 R 386585 CDS NP_308090.1 15829317 913463 complement(65290..68196) 1 NC_002695.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 68196 913463 ECs0063 Escherichia coli O157:H7 str. Sakai ATP-dependent helicase HepA NP_308090.1 65290 R 386585 CDS NP_308091.1 15829318 913464 complement(68360..70711) 1 NC_002695.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 70711 913464 ECs0064 Escherichia coli O157:H7 str. Sakai DNA polymerase II NP_308091.1 68360 R 386585 CDS NP_308092.1 15829319 913465 complement(70786..71481) 1 NC_002695.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 71481 araD 913465 araD Escherichia coli O157:H7 str. Sakai L-ribulose-5-phosphate 4-epimerase NP_308092.1 70786 R 386585 CDS NP_308093.1 15829320 913468 complement(71681..73183) 1 NC_002695.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 73183 913468 ECs0066 Escherichia coli O157:H7 str. Sakai L-arabinose isomerase NP_308093.1 71681 R 386585 CDS NP_308094.1 15829321 913471 complement(73194..74894) 1 NC_002695.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 74894 913471 ECs0067 Escherichia coli O157:H7 str. Sakai ribulokinase NP_308094.1 73194 R 386585 CDS NP_308095.1 15829322 913473 75233..76111 1 NC_002695.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; AraC family transcriptional regulator 76111 913473 ECs0068 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_308095.1 75233 D 386585 CDS NP_308096.1 15829323 913477 76197..76961 1 NC_002695.1 similar to YABI_ECOLI gi|1786252 (conserved in Escherichia coli K-12); hypothetical protein 76961 913477 ECs0069 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308096.1 76197 D 386585 CDS NP_308097.1 15829324 913478 complement(77048..77746) 1 NC_002695.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding protein 77746 thiQ 913478 thiQ Escherichia coli O157:H7 str. Sakai thiamine transporter ATP-binding protein NP_308097.1 77048 R 386585 CDS NP_308098.1 15829325 913479 complement(77730..79340) 1 NC_002695.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 79340 thiP 913479 thiP Escherichia coli O157:H7 str. Sakai thiamine transporter membrane protein NP_308098.1 77730 R 386585 CDS NP_308099.1 15829326 913490 complement(79316..80299) 1 NC_002695.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 80299 tbpA 913490 tbpA Escherichia coli O157:H7 str. Sakai thiamine transporter substrate binding subunit NP_308099.1 79316 R 386585 CDS NP_308100.1 15829327 913497 80671..81240 1 NC_002695.1 similar to YABP_ECOLI gi|2506583|sp|P39220; hypothetical protein 81240 913497 ECs0073 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308100.1 80671 D 386585 CDS NP_308101.1 15829328 913502 complement(81469..83127) 1 NC_002695.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 83127 913502 ECs0074 Escherichia coli O157:H7 str. Sakai transcriptional regulator SgrR NP_308101.1 81469 R 386585 CDS NP_308102.1 15829329 913503 complement(83455..84060) 1 NC_002695.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 84060 leuD 913503 leuD Escherichia coli O157:H7 str. Sakai isopropylmalate isomerase small subunit NP_308102.1 83455 R 386585 CDS NP_308103.1 15829330 913504 complement(84071..85471) 1 NC_002695.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 85471 913504 ECs0076 Escherichia coli O157:H7 str. Sakai isopropylmalate isomerase large subunit NP_308103.1 84071 R 386585 CDS NP_308104.2 38703842 913510 complement(85474..86565) 1 NC_002695.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 86565 913510 ECs0077 Escherichia coli O157:H7 str. Sakai 3-isopropylmalate dehydrogenase NP_308104.2 85474 R 386585 CDS NP_308105.1 15829332 913513 complement(86565..88136) 1 NC_002695.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 88136 913513 ECs0078 Escherichia coli O157:H7 str. Sakai 2-isopropylmalate synthase NP_308105.1 86565 R 386585 CDS NP_308106.1 15829333 913517 complement(88229..88315) 1 NC_002695.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 88315 913517 ECs0079 Escherichia coli O157:H7 str. Sakai leu operon leader peptide NP_308106.1 88229 R 386585 CDS NP_308107.2 162139819 913520 88955..89917 1 NC_002695.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 89917 leuO 913520 leuO Escherichia coli O157:H7 str. Sakai leucine transcriptional activator NP_308107.2 88955 D 386585 CDS NP_308108.2 38703843 913521 90235..91959 1 NC_002695.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 91959 913521 ECs0081 Escherichia coli O157:H7 str. Sakai acetolactate synthase 3 catalytic subunit NP_308108.2 90235 D 386585 CDS NP_308109.1 15829336 913523 91962..92453 1 NC_002695.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 92453 ilvH 913523 ilvH Escherichia coli O157:H7 str. Sakai acetolactate synthase 3 regulatory subunit NP_308109.1 91962 D 386585 CDS NP_308111.1 15829338 913527 92633..93637 1 NC_002695.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 93637 913527 ECs0084 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator FruR NP_308111.1 92633 D 386585 CDS NP_308112.1 15829339 913528 94239..94697 1 NC_002695.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 94697 913528 ECs0085 Escherichia coli O157:H7 str. Sakai cell division protein MraZ NP_308112.1 94239 D 386585 CDS NP_308113.1 15829340 913531 94699..95640 1 NC_002695.1 similar to YABC_ECOLI gi|1786270 (conserved in Escherichia coli K-12); S-adenosyl-methyltransferase MraW 95640 mraW 913531 mraW Escherichia coli O157:H7 str. Sakai S-adenosyl-methyltransferase MraW NP_308113.1 94699 D 386585 CDS NP_308114.1 15829341 913534 95637..96002 1 NC_002695.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 96002 ftsL 913534 ftsL Escherichia coli O157:H7 str. Sakai cell division protein FtsL NP_308114.1 95637 D 386585 CDS NP_308115.1 15829342 913535 96018..97784 1 NC_002695.1 septum formation protein; similar to FTSI_ECOLI gi|1786272 (conserved in Escherichia coli K-12); hypothetical protein 97784 ftsI 913535 ftsI Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308115.1 96018 D 386585 CDS NP_308116.1 15829343 913536 97771..99258 1 NC_002695.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 99258 murE 913536 murE Escherichia coli O157:H7 str. Sakai UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_308116.1 97771 D 386585 CDS NP_308117.1 15829344 913537 99255..100613 1 NC_002695.1 similar to MURF_ECOLI gi|1786274 (conserved in Escherichia coli K-12); UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 100613 murF 913537 murF Escherichia coli O157:H7 str. Sakai UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase NP_308117.1 99255 D 386585 CDS NP_308118.1 15829345 913542 100607..101689 1 NC_002695.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 101689 mraY 913542 mraY Escherichia coli O157:H7 str. Sakai phospho-N-acetylmuramoyl-pentapeptide- transferase NP_308118.1 100607 D 386585 CDS NP_308119.1 15829346 913546 101692..103008 1 NC_002695.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 103008 murD 913546 murD Escherichia coli O157:H7 str. Sakai UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_308119.1 101692 D 386585 CDS NP_308120.1 15829347 913549 103008..104252 1 NC_002695.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 104252 913549 ECs0093 Escherichia coli O157:H7 str. Sakai cell division protein FtsW NP_308120.1 103008 D 386585 CDS NP_308121.1 15829348 913552 104249..105316 1 NC_002695.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 105316 murG 913552 murG Escherichia coli O157:H7 str. Sakai undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_308121.1 104249 D 386585 CDS NP_308122.1 15829349 913555 105370..106845 1 NC_002695.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 106845 murC 913555 murC Escherichia coli O157:H7 str. Sakai UDP-N-acetylmuramate--L-alanine ligase NP_308122.1 105370 D 386585 CDS NP_308123.1 15829350 913558 106838..107758 1 NC_002695.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 107758 ddl 913558 ddl Escherichia coli O157:H7 str. Sakai D-alanine--D-alanine ligase NP_308123.1 106838 D 386585 CDS NP_308124.1 15829351 913560 107760..108590 1 NC_002695.1 involved in septum formation; cell division protein FtsQ 108590 913560 ECs0097 Escherichia coli O157:H7 str. Sakai cell division protein FtsQ NP_308124.1 107760 D 386585 CDS NP_308125.1 15829352 913567 108587..109849 1 NC_002695.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 109849 ftsA 913567 ftsA Escherichia coli O157:H7 str. Sakai cell division protein FtsA NP_308125.1 108587 D 386585 CDS NP_308126.1 15829353 913575 109910..111061 1 NC_002695.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 111061 913575 ECs0099 Escherichia coli O157:H7 str. Sakai cell division protein FtsZ NP_308126.1 109910 D 386585 CDS NP_308127.1 15829354 913579 111162..112079 1 NC_002695.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 112079 lpxC 913579 lpxC Escherichia coli O157:H7 str. Sakai UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NP_308127.1 111162 D 386585 CDS NP_308128.2 162139818 913588 112310..112822 1 NC_002695.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 112822 913588 ECs0101 Escherichia coli O157:H7 str. Sakai SecA regulator SecM NP_308128.2 112310 D 386585 CDS NP_308129.1 15829356 913599 112884..115589 1 NC_002695.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 115589 secA 913599 secA Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecA NP_308129.1 112884 D 386585 CDS NP_308130.1 15829357 913600 115649..116047 1 NC_002695.1 similar to MUTT_ECOLI gi|1786288 (conserved in Escherichia coli K-12); nucleoside triphosphate pyrophosphohydrolase 116047 913600 ECs0103 Escherichia coli O157:H7 str. Sakai nucleoside triphosphate pyrophosphohydrolase NP_308130.1 115649 D 386585 CDS NP_308132.1 15829359 913611 complement(116138..116335) 1 NC_002695.1 similar to YACG_ECOLI gi|1786290 (conserved in Escherichia coli K-12); zinc-binding protein 116335 913611 ECs0105 Escherichia coli O157:H7 str. Sakai zinc-binding protein NP_308132.1 116138 R 386585 CDS NP_308133.1 15829360 913614 complement(116345..117088) 1 NC_002695.1 similar to YACF_ECOLI gi|1786291 (conserved in Escherichia coli K-12); hypothetical protein 117088 913614 ECs0106 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308133.1 116345 R 386585 CDS NP_308134.1 15829361 913615 complement(117088..117708) 1 NC_002695.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 117708 coaE 913615 coaE Escherichia coli O157:H7 str. Sakai dephospho-CoA kinase NP_308134.1 117088 R 386585 CDS NP_308135.1 15829362 913617 117933..118976 1 NC_002695.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 118976 913617 ECs0108 Escherichia coli O157:H7 str. Sakai guanosine 5'-monophosphate oxidoreductase NP_308135.1 117933 D 386585 CDS NP_308137.1 15829364 913621 complement(119011..120213) 1 NC_002695.1 integral membrane protein; similar to HOFC_ECOLI gi|1786295 (conserved in Escherichia coli K-12); type IV pilin biogenesis protein 120213 913621 ECs0110 Escherichia coli O157:H7 str. Sakai type IV pilin biogenesis protein NP_308137.1 119011 R 386585 CDS NP_308138.1 15829365 913626 complement(120203..121588) 1 NC_002695.1 integral membrane protein; similar to HOFB_ECOLI gi|1786296 (conserved in Escherichia coli K-12); hypothetical protein 121588 913626 ECs0111 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308138.1 120203 R 386585 CDS NP_308139.1 15829366 913629 complement(121598..122038) 1 NC_002695.1 similar to PPDD_ECOLI gi|1786297 (conserved in Escherichia coli K-12); major pilin subunit 122038 913629 ECs0112 Escherichia coli O157:H7 str. Sakai major pilin subunit NP_308139.1 121598 R 386585 CDS NP_944499.1 38703844 2693812 122063..122284 1 NC_002695.1 hypothetical protein 122284 2693812 ECs5363 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944499.1 122063 D 386585 CDS NP_308140.1 15829367 913630 complement(122241..123134) 1 NC_002695.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 123134 913630 ECs0113 Escherichia coli O157:H7 str. Sakai quinolinate phosphoribosyltransferase NP_308140.1 122241 R 386585 CDS NP_308141.1 15829368 913635 123222..123773 1 NC_002695.1 similar to AMPD_ECOLI gi|1786300 (conserved in Escherichia coli K-12); N-acetyl-anhydromuranmyl-L-alanine amidase 123773 913635 ECs0114 Escherichia coli O157:H7 str. Sakai N-acetyl-anhydromuranmyl-L-alanine amidase NP_308141.1 123222 D 386585 CDS NP_308142.1 15829369 913637 123770..124624 1 NC_002695.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 124624 913637 ECs0115 Escherichia coli O157:H7 str. Sakai regulatory protein AmpE NP_308142.1 123770 D 386585 CDS NP_308143.1 15829370 913640 complement(124667..126040) 1 NC_002695.1 similar to AROP_ECOLI gi|1786302 (conserved in Escherichia coli K-12); aromatic amino acid transporter 126040 913640 ECs0116 Escherichia coli O157:H7 str. Sakai aromatic amino acid transporter NP_308143.1 124667 R 386585 CDS NP_308144.1 15829371 913643 126581..127345 1 NC_002695.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 127345 pdhR 913643 pdhR Escherichia coli O157:H7 str. Sakai transcriptional regulator PdhR NP_308144.1 126581 D 386585 CDS NP_308145.1 15829372 913657 127506..130169 1 NC_002695.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 130169 aceE 913657 aceE Escherichia coli O157:H7 str. Sakai pyruvate dehydrogenase subunit E1 NP_308145.1 127506 D 386585 CDS NP_308146.1 15829373 913659 130184..132076 1 NC_002695.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 132076 aceF 913659 aceF Escherichia coli O157:H7 str. Sakai dihydrolipoamide acetyltransferase NP_308146.1 130184 D 386585 CDS NP_308147.1 15829374 913660 132284..133708 1 NC_002695.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 133708 lpdA 913660 lpdA Escherichia coli O157:H7 str. Sakai dihydrolipoamide dehydrogenase NP_308147.1 132284 D 386585 CDS NP_308148.1 15829375 913666 complement(133779..135632) 1 NC_002695.1 similar to YACH_ECOLI gi|1786308 (conserved in Escherichia coli K-12); hypothetical protein 135632 913666 ECs0121 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308148.1 133779 R 386585 CDS NP_308149.1 15829376 913670 135987..138584 1 NC_002695.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 138584 913670 ECs0122 Escherichia coli O157:H7 str. Sakai bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase NP_308149.1 135987 D 386585 CDS NP_308150.2 162139817 913686 138760..139122 1 NC_002695.1 similar to YACL_ECOLI gi|1786310 (conserved in Escherichia coli K-12); hypothetical protein 139122 913686 ECs0123 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308150.2 138760 D 386585 CDS NP_308151.1 15829378 913693 complement(139160..139954) 1 NC_002695.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 139954 913693 ECs0124 Escherichia coli O157:H7 str. Sakai S-adenosylmethionine decarboxylase NP_308151.1 139160 R 386585 CDS NP_308152.1 15829379 913703 complement(139970..140836) 1 NC_002695.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 140836 913703 ECs0125 Escherichia coli O157:H7 str. Sakai spermidine synthase NP_308152.1 139970 R 386585 CDS NP_308153.2 38703845 913704 complement(140942..141289) 1 NC_002695.1 similar to YACC_ECOLI gi|1786313 (conserved in Escherichia coli K-12); hypothetical protein 141289 913704 ECs0126 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308153.2 140942 R 386585 CDS NP_308154.1 15829381 913706 141455..143005 1 NC_002695.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 143005 913706 ECs0127 Escherichia coli O157:H7 str. Sakai multicopper oxidase NP_308154.1 141455 D 386585 CDS NP_308155.1 15829382 913709 complement(143207..145597) 1 NC_002695.1 similar to GCD_ECOLI gi|1786316 (conserved in Escherichia coli K-12); glucose dehydrogenase 145597 913709 ECs0128 Escherichia coli O157:H7 str. Sakai glucose dehydrogenase NP_308155.1 143207 R 386585 CDS NP_308156.2 38703846 913711 145803..146339 1 NC_002695.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 146339 913711 ECs0129 Escherichia coli O157:H7 str. Sakai hypoxanthine-guanine phosphoribosyltransferase NP_308156.2 145803 D 386585 CDS NP_308157.1 15829384 913712 complement(146380..147042) 1 NC_002695.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 147042 913712 ECs0130 Escherichia coli O157:H7 str. Sakai carbonic anhydrase NP_308157.1 146380 R 386585 CDS NP_308158.1 15829385 913713 147151..148077 1 NC_002695.1 similar to YADG_ECOLI gi|1786319 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 148077 913713 ECs0131 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308158.1 147151 D 386585 CDS NP_308159.1 15829386 913717 148074..148844 1 NC_002695.1 similar to YADH_ECOLI gi|1786320 (conserved in Escherichia coli K-12); hypothetical protein 148844 913717 ECs0132 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308159.1 148074 D 386585 CDS NP_308160.1 15829387 913720 148949..149389 1 NC_002695.1 similar to YADI_ECOLI gi|1786321 (conserved in Escherichia coli K-12); PTS enzyme II B component 149389 913720 ECs0133 Escherichia coli O157:H7 str. Sakai PTS enzyme II B component NP_308160.1 148949 D 386585 CDS NP_308161.1 15829388 913723 149453..150682 1 NC_002695.1 similar to YADE_ECOLI gi|1786322 (conserved in Escherichia coli K-12); hypothetical protein 150682 913723 ECs0134 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308161.1 149453 D 386585 CDS NP_308162.1 15829389 913727 complement(150686..151066) 1 NC_002695.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 151066 913727 ECs0135 Escherichia coli O157:H7 str. Sakai aspartate alpha-decarboxylase NP_308162.1 150686 R 386585 CDS NP_308163.1 15829390 913728 151340..152236 1 NC_002695.1 similar to YADD_ECOLI gi|1786324 (conserved in Escherichia coli K-12); hypothetical protein 152236 913728 ECs0136 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308163.1 151340 D 386585 CDS NP_308164.1 15829391 913734 complement(152535..153386) 1 NC_002695.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 153386 panC 913734 panC Escherichia coli O157:H7 str. Sakai pantoate--beta-alanine ligase NP_308164.1 152535 R 386585 CDS NP_308165.1 15829392 913736 complement(153398..154192) 1 NC_002695.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 154192 panB 913736 panB Escherichia coli O157:H7 str. Sakai 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_308165.1 153398 R 386585 CDS NP_308166.1 15829393 913739 complement(154327..155436) 1 NC_002695.1 probable fimbrial protein, similar to probable fimbrial proteins e.g. [Escherichia coli] gi|538781|pir||B47152, long polar fimbrial minor protein LpfE [Salmonella typhimurium] gi|1170819|sp|P43664|LPFE_SALTY; fimbrial protein 155436 913739 ECs0139 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_308166.1 154327 R 386585 CDS NP_308167.1 15829394 913740 complement(155448..156038) 1 NC_002695.1 probable fimbrial protein, similar to fimbrial protein YadK [Escherichia coli] gi|549488|sp|P37016|YADK_ECOLI; fimbrial protein 156038 913740 ECs0140 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_308167.1 155448 R 386585 CDS NP_308168.1 15829395 913742 complement(156059..156664) 1 NC_002695.1 probable fimbrial protein, similar to fimbrial protein YadL [Escherichia coli] gi|549489|sp|P37017|YADL_ECOLI; fimbrial protein 156664 913742 ECs0141 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_308168.1 156059 R 386585 CDS NP_308169.1 15829396 913744 complement(156679..157239) 1 NC_002695.1 probable fimbrial protein, similar to fimbrial-like protein YadM [Escherichia coli] gi|549490|sp|P37018|YADM_ECOLI; fimbrial protein 157239 913744 ECs0142 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_308169.1 156679 R 386585 CDS NP_308170.1 15829397 913748 complement(157241..159841) 1 NC_002695.1 similar to the fimbrial usher protein PapC; outer membrane usher protein 159841 913748 ECs0143 Escherichia coli O157:H7 str. Sakai outer membrane usher protein NP_308170.1 157241 R 386585 CDS NP_308171.1 15829398 913756 complement(159883..160608) 1 NC_002695.1 similar to ECPD_ECOLI gi|1786333; chaperone protein EcpD 160608 913756 ECs0144 Escherichia coli O157:H7 str. Sakai chaperone protein EcpD NP_308171.1 159883 R 386585 CDS NP_308172.1 15829399 913761 complement(160695..161291) 1 NC_002695.1 similar to YADN_ECOLI gi|1786334; fimbrial-like protein 161291 913761 ECs0145 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_308172.1 160695 R 386585 CDS NP_308173.1 15829400 913762 complement(161572..162054) 1 NC_002695.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 162054 913762 ECs0146 Escherichia coli O157:H7 str. Sakai 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_308173.1 161572 R 386585 CDS NP_308174.2 162139816 913763 complement(162051..163469) 1 NC_002695.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 163469 pcnB 913763 pcnB Escherichia coli O157:H7 str. Sakai poly(A) polymerase NP_308174.2 162051 R 386585 CDS NP_308175.2 162139815 913766 complement(163508..164404) 1 NC_002695.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 164404 913766 ECs0148 Escherichia coli O157:H7 str. Sakai glutamyl-Q tRNA(Asp) synthetase NP_308175.2 163508 R 386585 CDS NP_308176.1 15829403 913772 complement(164471..164926) 1 NC_002695.1 similar to DKSA_ECOLI gi|1786338 (conserved in Escherichia coli K-12); RNA polymerase-binding transcription factor 164926 dksA 913772 dksA Escherichia coli O157:H7 str. Sakai RNA polymerase-binding transcription factor NP_308176.1 164471 R 386585 CDS NP_308177.1 15829404 913774 complement(165104..165808) 1 NC_002695.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 165808 913774 ECs0150 Escherichia coli O157:H7 str. Sakai sugar fermentation stimulation protein A NP_308177.1 165104 R 386585 CDS NP_308178.2 38703847 913775 complement(165823..166353) 1 NC_002695.1 similar to YADP_ECOLI gi|1786341 (conserved in Escherichia coli K-12); 2'-5' RNA ligase 166353 913775 ECs0151 Escherichia coli O157:H7 str. Sakai 2'-5' RNA ligase NP_308178.2 165823 R 386585 CDS NP_308179.1 15829406 913779 166382..168856 1 NC_002695.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 168856 913779 ECs0152 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase HrpB NP_308179.1 166382 D 386585 CDS NP_944500.1 38703848 2693813 168859..169065 1 NC_002695.1 hypothetical protein 169065 2693813 ECs5364 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944500.1 168859 D 386585 CDS NP_308180.1 15829407 913781 169052..171586 1 NC_002695.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 171586 mrcB 913781 mrcB Escherichia coli O157:H7 str. Sakai penicillin-binding protein 1b NP_308180.1 169052 D 386585 CDS NP_308181.1 15829408 913783 171806..174049 1 NC_002695.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 174049 913783 ECs0154 Escherichia coli O157:H7 str. Sakai ferrichrome outer membrane transporter NP_308181.1 171806 D 386585 CDS NP_308182.1 15829409 913784 174100..174897 1 NC_002695.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding protein 174897 913784 ECs0155 Escherichia coli O157:H7 str. Sakai iron-hydroxamate transporter ATP-binding protein NP_308182.1 174100 D 386585 CDS NP_308183.1 15829410 913786 174897..175787 1 NC_002695.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 175787 913786 ECs0156 Escherichia coli O157:H7 str. Sakai iron-hydroxamate transporter substrate-binding subunit NP_308183.1 174897 D 386585 CDS NP_308184.1 15829411 913787 175784..177766 1 NC_002695.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease 177766 913787 ECs0157 Escherichia coli O157:H7 str. Sakai iron-hydroxamate transporter permease NP_308184.1 175784 D 386585 CDS NP_308185.1 15829412 913788 complement(177801..179081) 1 NC_002695.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 179081 913788 ECs0158 Escherichia coli O157:H7 str. Sakai glutamate-1-semialdehyde aminotransferase NP_308185.1 177801 R 386585 CDS NP_308186.1 15829413 913789 179306..180727 1 NC_002695.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 180727 913789 ECs0159 Escherichia coli O157:H7 str. Sakai chloride channel protein NP_308186.1 179306 D 386585 CDS NP_308187.1 15829414 913801 180809..181153 1 NC_002695.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 181153 913801 ECs0160 Escherichia coli O157:H7 str. Sakai iron-sulfur cluster insertion protein ErpA NP_308187.1 180809 D 386585 CDS NP_308188.1 15829415 913809 complement(181200..181823) 1 NC_002695.1 similar to YADS_ECOLI gi|1786352 (conserved in Escherichia coli K-12); hypothetical protein 181823 913809 ECs0161 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308188.1 181200 R 386585 CDS NP_308189.1 15829416 913812 complement(181861..182661) 1 NC_002695.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 182661 913812 ECs0162 Escherichia coli O157:H7 str. Sakai vitamin B12-transporter protein BtuF NP_308189.1 181861 R 386585 CDS NP_308190.1 15829417 913817 complement(182654..183352) 1 NC_002695.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 183352 913817 ECs0163 Escherichia coli O157:H7 str. Sakai 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_308190.1 182654 R 386585 CDS NP_308191.1 15829418 913819 183436..184953 1 NC_002695.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 184953 dgt 913819 dgt Escherichia coli O157:H7 str. Sakai deoxyguanosinetriphosphate triphosphohydrolase NP_308191.1 183436 D 386585 CDS NP_308192.1 15829419 913821 185083..186507 1 NC_002695.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 186507 913821 ECs0165 Escherichia coli O157:H7 str. Sakai serine endoprotease NP_308192.1 185083 D 386585 CDS NP_308193.1 15829420 913826 186662..187819 1 NC_002695.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 187819 913826 ECs0166 Escherichia coli O157:H7 str. Sakai carbohydrate diacid transcriptional activator CdaR NP_308193.1 186662 D 386585 CDS NP_308194.1 15829421 913827 complement(187908..188294) 1 NC_002695.1 similar to YAEH_ECOLI gi|1786359 (conserved in Escherichia coli K-12); hypothetical protein 188294 913827 ECs0167 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308194.1 187908 R 386585 CDS NP_308195.1 15829422 913832 complement(188609..189433) 1 NC_002695.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 189433 dapD 913832 dapD Escherichia coli O157:H7 str. Sakai 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_308195.1 188609 R 386585 CDS NP_308196.1 15829423 913839 complement(189464..192136) 1 NC_002695.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 192136 913839 ECs0169 Escherichia coli O157:H7 str. Sakai PII uridylyl-transferase NP_308196.1 189464 R 386585 CDS NP_308197.1 15829424 913847 complement(192198..192992) 1 NC_002695.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 192992 913847 ECs0170 Escherichia coli O157:H7 str. Sakai methionine aminopeptidase NP_308197.1 192198 R 386585 CDS NP_308198.1 15829425 913849 193360..194085 1 NC_002695.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 194085 rpsB 913849 rpsB Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S2 NP_308198.1 193360 D 386585 CDS NP_308199.1 15829426 913854 194343..195194 1 NC_002695.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 195194 tsf 913854 tsf Escherichia coli O157:H7 str. Sakai elongation factor Ts NP_308199.1 194343 D 386585 CDS NP_308200.1 15829427 913857 195341..196066 1 NC_002695.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 196066 pyrH 913857 pyrH Escherichia coli O157:H7 str. Sakai uridylate kinase NP_308200.1 195341 D 386585 CDS NP_308201.1 15829428 913872 196216..196773 1 NC_002695.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 196773 frr 913872 frr Escherichia coli O157:H7 str. Sakai ribosome recycling factor NP_308201.1 196216 D 386585 CDS NP_308202.1 15829429 913875 196865..198061 1 NC_002695.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 198061 913875 ECs0175 Escherichia coli O157:H7 str. Sakai 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_308202.1 196865 D 386585 CDS NP_308203.1 15829430 913882 198247..199008 1 NC_002695.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 199008 913882 ECs0176 Escherichia coli O157:H7 str. Sakai undecaprenyl pyrophosphate synthase NP_308203.1 198247 D 386585 CDS NP_308204.2 162139814 913883 199021..199878 1 NC_002695.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 199878 cdsA 913883 cdsA Escherichia coli O157:H7 str. Sakai CDP-diglyceride synthase NP_308204.2 199021 D 386585 CDS NP_308205.1 15829432 913885 199890..201242 1 NC_002695.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 201242 913885 ECs0178 Escherichia coli O157:H7 str. Sakai zinc metallopeptidase RseP NP_308205.1 199890 D 386585 CDS NP_308206.1 15829433 913887 201272..203704 1 NC_002695.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 203704 913887 ECs0179 Escherichia coli O157:H7 str. Sakai outer membrane protein assembly factor YaeT NP_308206.1 201272 D 386585 CDS NP_308207.1 15829434 913889 203825..204310 1 NC_002695.1 histone-like protein; similar to HLPA_ECOLI gi|1786375 (conserved in Escherichia coli K-12); periplasmic chaperone 204310 913889 ECs0180 Escherichia coli O157:H7 str. Sakai periplasmic chaperone NP_308207.1 203825 D 386585 CDS NP_308208.1 15829435 913891 204314..205339 1 NC_002695.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 205339 lpxD 913891 lpxD Escherichia coli O157:H7 str. Sakai UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NP_308208.1 204314 D 386585 CDS NP_308209.1 15829436 913892 205444..205899 1 NC_002695.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 205899 fabZ 913892 fabZ Escherichia coli O157:H7 str. Sakai (3R)-hydroxymyristoyl-ACP dehydratase NP_308209.1 205444 D 386585 CDS NP_308210.1 15829437 913893 205903..206691 1 NC_002695.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 206691 913893 ECs0183 Escherichia coli O157:H7 str. Sakai UDP-N-acetylglucosamine acyltransferase NP_308210.1 205903 D 386585 CDS NP_308211.1 15829438 913894 206691..207839 1 NC_002695.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 207839 lpxB 913894 lpxB Escherichia coli O157:H7 str. Sakai lipid-A-disaccharide synthase NP_308211.1 206691 D 386585 CDS NP_308212.1 15829439 913902 207836..208432 1 NC_002695.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 208432 rnhB 913902 rnhB Escherichia coli O157:H7 str. Sakai ribonuclease HII NP_308212.1 207836 D 386585 CDS NP_308213.1 15829440 913906 208469..211951 1 NC_002695.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 211951 dnaE 913906 dnaE Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit alpha NP_308213.1 208469 D 386585 CDS NP_308214.1 15829441 913907 211964..212923 1 NC_002695.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 212923 913907 ECs0187 Escherichia coli O157:H7 str. Sakai acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_308214.1 211964 D 386585 CDS NP_308215.1 15829442 913910 213022..215163 1 NC_002695.1 similar to LDCC_ECOLI gi|1786384 (conserved in Escherichia coli K-12); lysine decarboxylase 2 215163 913910 ECs0188 Escherichia coli O157:H7 str. Sakai lysine decarboxylase 2 NP_308215.1 213022 D 386585 CDS NP_308216.2 38703849 913914 215220..215609 1 NC_002695.1 similar to YAER_ECOLI gi|1786385 (conserved in Escherichia coli K-12); hypothetical protein 215609 913914 ECs0189 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308216.2 215220 D 386585 CDS NP_308217.1 15829444 913916 215674..216969 1 NC_002695.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 216969 tilS 913916 tilS Escherichia coli O157:H7 str. Sakai tRNA(Ile)-lysidine synthetase NP_308217.1 215674 D 386585 CDS NP_308218.1 15829445 913917 complement(217022..217282) 1 NC_002695.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 217282 913917 ECs0191 Escherichia coli O157:H7 str. Sakai Rho-binding antiterminator NP_308218.1 217022 R 386585 CDS NP_944501.1 38703850 2693788 complement(217269..217487) 1 NC_002695.1 hypothetical protein 217487 2693788 ECs5365 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944501.1 217269 R 386585 CDS NP_308219.1 15829446 913918 217635..218093 1 NC_002695.1 similar to YAEQ_ECOLI gi|1786388 (conserved in Escherichia coli K-12); hypothetical protein 218093 913918 ECs0192 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308219.1 217635 D 386585 CDS NP_308220.1 15829447 913932 218177..218587 1 NC_002695.1 similar to YAEJ_ECOLI gi|1786389 (conserved in Escherichia coli K-12); peptidyl-tRNA hydrolase domain-containing protein 218587 913932 ECs0193 Escherichia coli O157:H7 str. Sakai peptidyl-tRNA hydrolase domain-containing protein NP_308220.1 218177 D 386585 CDS NP_308221.1 15829448 913936 218601..219311 1 NC_002695.1 similar to CUTF_ECOLI gi|1786390 (conserved in Escherichia coli K-12); lipoprotein involved with copper homeostasis and adhesion 219311 913936 ECs0194 Escherichia coli O157:H7 str. Sakai lipoprotein involved with copper homeostasis and adhesion NP_308221.1 218601 D 386585 CDS NP_308222.1 15829449 913937 complement(219511..220335) 1 NC_002695.1 similar to YAEF_ECOLI gi|1786391 (conserved in Escherichia coli K-12); hypothetical protein 220335 913937 ECs0195 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308222.1 219511 R 386585 CDS NP_308223.1 15829450 913939 complement(220388..222106) 1 NC_002695.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 222106 913939 ECs0196 Escherichia coli O157:H7 str. Sakai prolyl-tRNA synthetase NP_308223.1 220388 R 386585 CDS NP_308224.1 15829451 913945 complement(222217..222924) 1 NC_002695.1 similar to YAEB_ECOLI gi|1786393 (conserved in Escherichia coli K-12); hypothetical protein 222924 913945 ECs0197 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308224.1 222217 R 386585 CDS NP_308225.1 15829452 913950 complement(222921..223325) 1 NC_002695.1 similar to RCSF_ECOLI gi|1786394 (conserved in Escherichia coli K-12); outer membrane lipoprotein 223325 rcsF 913950 rcsF Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein NP_308225.1 222921 R 386585 CDS NP_308226.1 15829453 913959 complement(223443..224258) 1 NC_002695.1 similar to YAEC_ECOLI gi|1786396 (conserved in Escherichia coli K-12); DL-methionine transporter substrate-binding subunit 224258 metQ 913959 metQ Escherichia coli O157:H7 str. Sakai DL-methionine transporter substrate-binding subunit NP_308226.1 223443 R 386585 CDS NP_308227.1 15829454 913960 complement(224298..224951) 1 NC_002695.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease 224951 913960 ECs0200 Escherichia coli O157:H7 str. Sakai DL-methionine transporter permease NP_308227.1 224298 R 386585 CDS NP_308228.1 15829455 913972 complement(224944..225975) 1 NC_002695.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding protein 225975 metN 913972 metN Escherichia coli O157:H7 str. Sakai DL-methionine transporter ATP-binding protein NP_308228.1 224944 R 386585 CDS NP_308229.1 15829456 913974 226163..226738 1 NC_002695.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 226738 913974 ECs0202 Escherichia coli O157:H7 str. Sakai D,D-heptose 1,7-bisphosphate phosphatase NP_308229.1 226163 D 386585 CDS NP_308230.1 15829457 914031 232496..233299 1 NC_002695.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 233299 dkgB 914031 dkgB Escherichia coli O157:H7 str. Sakai 2,5-diketo-D-gluconate reductase B NP_308230.1 232496 D 386585 CDS NP_308231.1 15829458 914036 complement(233296..234210) 1 NC_002695.1 similar to YAFC_ECOLI gi|1786401 (conserved in Escherichia coli K-12); transcriptional regulator 234210 914036 ECs0204 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308231.1 233296 R 386585 CDS NP_308232.1 15829459 914037 234451..235251 1 NC_002695.1 similar to YAFD_ECOLI gi|1786403 (conserved in Escherichia coli K-12); hypothetical protein 235251 914037 ECs0205 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308232.1 234451 D 386585 CDS NP_308233.1 15829460 914039 235329..236099 1 NC_002695.1 C-terminal part (52-256 in 256 aa) is similar to YEFE_ECOLI gi|1786404 (conserved in Escherichia coli K-12); biotin synthesis protein 236099 914039 ECs0206 Escherichia coli O157:H7 str. Sakai biotin synthesis protein NP_308233.1 235329 D 386585 CDS NP_308234.1 15829461 914041 complement(236147..237505) 1 NC_002695.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 237505 mltD 914041 mltD Escherichia coli O157:H7 str. Sakai membrane-bound lytic murein transglycosylase D NP_308234.1 236147 R 386585 CDS NP_308235.1 15829462 914044 complement(237577..238332) 1 NC_002695.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 238332 914044 ECs0208 Escherichia coli O157:H7 str. Sakai hydroxyacylglutathione hydrolase NP_308235.1 237577 R 386585 CDS NP_308236.1 15829463 914047 238348..239088 1 NC_002695.1 similar to YAFS_ECOLI gi|1786407 (conserved in Escherichia coli K-12); hypothetical protein 239088 914047 ECs0209 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308236.1 238348 D 386585 CDS NP_308237.1 15829464 914053 complement(239085..239552) 1 NC_002695.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 239552 rnhA 914053 rnhA Escherichia coli O157:H7 str. Sakai ribonuclease H NP_308237.1 239085 R 386585 CDS NP_308238.1 15829465 914056 239617..240348 1 NC_002695.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 240348 914056 ECs0211 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit epsilon NP_308238.1 239617 D 386585 CDS NP_308239.1 15829466 914062 complement(241871..242167) 1 NC_002695.1 hypothetical protein 242167 914062 ECs0212 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308239.1 241871 R 386585 CDS NP_308240.1 15829467 914064 complement(242164..242613) 1 NC_002695.1 hypothetical protein 242613 914064 ECs0213 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308240.1 242164 R 386585 CDS NP_308241.1 15829468 914067 complement(242616..243263) 1 NC_002695.1 hypothetical protein 243263 914067 ECs0214 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308241.1 242616 R 386585 CDS NP_308243.1 15829470 914071 complement(243533..244012) 1 NC_002695.1 similar tohemolysin-coregulated protein Hcp [Vibrio cholerae] gi|7467495|pir||T10891, hypothetical 44.2 kD protein YhhZ [Escherichia coli (strain K-12)] gi|1176284|sp|P46855|YHHZ_ECOLI; Hcp-like protein 244012 914071 ECs0216 Escherichia coli O157:H7 str. Sakai Hcp-like protein NP_308243.1 243533 R 386585 CDS NP_308244.1 15829471 914077 complement(243978..245387) 1 NC_002695.1 hypothetical protein 245387 914077 ECs0217 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308244.1 243978 R 386585 CDS NP_308245.1 15829472 914079 complement(245398..248505) 1 NC_002695.1 similar to IcmF protein [Legionella pneumophila] gi|7465644|pir||T18341; IcmF-like protein 248505 914079 ECs0218 Escherichia coli O157:H7 str. Sakai IcmF-like protein NP_308245.1 245398 R 386585 CDS NP_308247.1 15829474 914081 complement(248969..249763) 1 NC_002695.1 hypothetical protein 249763 914081 ECs0220 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308247.1 248969 R 386585 CDS NP_308248.1 15829475 914084 complement(249760..250380) 1 NC_002695.1 hypothetical protein 250380 914084 ECs0221 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308248.1 249760 R 386585 CDS NP_308249.1 15829476 914092 complement(250385..251128) 1 NC_002695.1 hypothetical protein 251128 914092 ECs0222 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308249.1 250385 R 386585 CDS NP_308250.1 15829477 914094 complement(251125..253896) 1 NC_002695.1 similar to ATP-dependent Clp proteinase ATP-binding chains ClpB e.g. gi|7428220|pir||T07807; ATP-dependent Clp proteinase ATP-binding chain 253896 914094 ECs0223 Escherichia coli O157:H7 str. Sakai ATP-dependent Clp proteinase ATP-binding chain NP_308250.1 251125 R 386585 CDS NP_308251.1 15829478 914096 complement(253905..254666) 1 NC_002695.1 hypothetical protein 254666 914096 ECs0224 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308251.1 253905 R 386585 CDS NP_308252.1 15829479 914109 complement(254671..256002) 1 NC_002695.1 similar to hypothetical protein z29f Vibrio cholerae CAA13133; hypothetical protein 256002 914109 ECs0225 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308252.1 254671 R 386585 CDS NP_308253.1 15829480 914114 complement(256005..256529) 1 NC_002695.1 lipoprotein 256529 914114 ECs0226 Escherichia coli O157:H7 str. Sakai lipoprotein NP_308253.1 256005 R 386585 CDS NP_308254.1 15829481 914116 complement(256526..257806) 1 NC_002695.1 hypothetical protein 257806 914116 ECs0227 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308254.1 256526 R 386585 CDS NP_308255.1 15829482 914121 complement(257831..258913) 1 NC_002695.1 hypothetical protein 258913 914121 ECs0228 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308255.1 257831 R 386585 CDS NP_308256.1 15829483 914124 complement(258877..260727) 1 NC_002695.1 hypothetical protein 260727 914124 ECs0229 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308256.1 258877 R 386585 CDS NP_308257.1 15829484 914125 complement(260731..261144) 1 NC_002695.1 similar to base plate protein and acidic lysozyme [coliphage T4] gi|137980|sp|P09425|VG25_BPT4; hypothetical protein 261144 914125 ECs0230 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308257.1 260731 R 386585 CDS NP_308258.1 15829485 914127 complement(261235..262626) 1 NC_002695.1 similar to hypothetical 54.5 kDa protein [Edwardsiella ictaluri] gi|2708666|gb|AAB92576.1; hypothetical protein 262626 914127 ECs0231 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308258.1 261235 R 386585 CDS NP_308259.1 15829486 914129 complement(262677..262901) 1 NC_002695.1 hypothetical protein 262901 914129 ECs0232 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308259.1 262677 R 386585 CDS NP_308260.1 15829487 914131 complement(262936..263436) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|2920642|gb|AAC32477.1; similar tohypothetical 19.5 kDa protein [Edwardsiella ictaluri] gi|2708667|gb|AAB92577.1; hypothetical protein 263436 914131 ECs0233 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308260.1 262936 R 386585 CDS NP_308261.1 15829488 914133 264133..264651 1 NC_002695.1 hypothetical protein 264651 914133 ECs0234 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308261.1 264133 D 386585 CDS NP_308262.1 15829489 914159 264684..264821 1 NC_002695.1 hypothetical protein 264821 914159 ECs0235 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308262.1 264684 D 386585 CDS NP_308263.1 15829490 914167 264861..267002 1 NC_002695.1 similar to VgrG [Escherichia coli strain ec11] gi|2920640|gb|AAC32475.1; protein VgrG 267002 914167 ECs0236 Escherichia coli O157:H7 str. Sakai protein VgrG NP_308263.1 264861 D 386585 CDS NP_308264.1 15829491 914169 267078..271292 1 NC_002695.1 Rhs protein; similar to RhsH proteins e.g. [Escherichia coli strain EC45] gi|2920634|gb|AAC32471.1; RhsG core protein with extension 271292 914169 ECs0237 Escherichia coli O157:H7 str. Sakai RhsG core protein with extension NP_308264.1 267078 D 386585 CDS NP_308265.1 15829492 914172 271295..271906 1 NC_002695.1 similar to YbeQ [Escherichia coli] gi|3025010|sp|P77234; similar toYibG [Escherichia coli] gi|418454|sp|P32106|YIBG_ECOLI; hypothetical protein 271906 914172 ECs0238 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308265.1 271295 D 386585 CDS NP_308266.1 15829493 914174 271928..272110 1 NC_002695.1 hypothetical protein 272110 914174 ECs0239 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308266.1 271928 D 386585 CDS NP_308267.1 15829494 914178 272254..272544 1 NC_002695.1 hypothetical protein 272544 914178 ECs0240 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308267.1 272254 D 386585 CDS NP_308268.1 15829495 914217 272652..273788 1 NC_002695.1 similar to H repeat-associated proteins e.g. [Escherichia coli RhsB element] gi|140772|sp|P28912; H repeat-containing protein 273788 914217 ECs0241 Escherichia coli O157:H7 str. Sakai H repeat-containing protein NP_308268.1 272652 D 386585 CDS NP_308269.1 15829496 914218 273791..275551 1 NC_002695.1 Rhs protein; similar to Rhs core proteins e.g. RhsE [Escherichia coli] gi|2507113|sp|P24211|RHSE_ECOLI; Rhs core protein 275551 914218 ECs0242 Escherichia coli O157:H7 str. Sakai Rhs core protein NP_308269.1 273791 D 386585 CDS NP_308270.1 15829497 914228 275535..275705 1 NC_002695.1 similar to N-terminal parts of hypothetical proteins e.g. ORF E2 in Rhs element [Escherichia coli] gi|2851489|sp|P31991; hypothetical protein 275705 914228 ECs0243 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308270.1 275535 D 386585 CDS NP_308271.1 15829498 914250 275753..276016 1 NC_002695.1 similar to C-terminal parts of hypothetical proteins e.g. ORF E2 in Rhs element [Escherichia coli] gi|2851489|sp|P31991; hypothetical protein 276016 914250 ECs0244 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308271.1 275753 D 386585 CDS NP_308272.1 15829499 914277 276197..277369 1 NC_002695.1 similar to H repeat-associated proteins e.g. [Escherichia coli RhsB element] gi|7465875|pir||E64898; H repeat-containing protein 277369 914277 ECs0245 Escherichia coli O157:H7 str. Sakai H repeat-containing protein NP_308272.1 276197 D 386585 CDS NP_308273.1 15829500 914330 complement(277487..278257) 1 NC_002695.1 similar to YAFV_ECOLI gi|1786412 (conserved in Escherichia coli K-12); hypothetical protein 278257 914330 ECs0246 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308273.1 277487 R 386585 CDS NP_308274.1 15829501 914333 278411..278884 1 NC_002695.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 278884 914333 ECs0247 Escherichia coli O157:H7 str. Sakai C-lysozyme inhibitor NP_308274.1 278411 D 386585 CDS NP_308275.2 162139813 914334 complement(278927..281371) 1 NC_002695.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 281371 fadE 914334 fadE Escherichia coli O157:H7 str. Sakai acyl-CoA dehydrogenase NP_308275.2 278927 R 386585 CDS NP_308276.1 15829503 914335 281611..282189 1 NC_002695.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 282189 gmhA 914335 gmhA Escherichia coli O157:H7 str. Sakai phosphoheptose isomerase NP_308276.1 281611 D 386585 CDS NP_308277.1 15829504 914337 282294..283061 1 NC_002695.1 similar to YAFJ_ECOLI gi|1786417 (conserved in Escherichia coli K-12); amidotransferase 283061 914337 ECs0250 Escherichia coli O157:H7 str. Sakai amidotransferase NP_308277.1 282294 D 386585 CDS NP_308278.1 15829505 914338 complement(283032..283772) 1 NC_002695.1 similar to YAFK_ECOLI gi|1786418 (conserved in Escherichia coli K-12); hypothetical protein 283772 914338 ECs0251 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308278.1 283032 R 386585 CDS NP_308279.1 15829506 914339 complement(283928..284188) 1 NC_002695.1 similar to YAFQ_ECOLI gi|1786419 (conserved in Escherichia coli K-12); hypothetical protein 284188 914339 ECs0252 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308279.1 283928 R 386585 CDS NP_308280.1 15829507 914340 complement(284207..284467) 1 NC_002695.1 damage-inducible protein; similar to DINJ_ECOLI gi|1786420 (conserved in Escherichia coli K-12); protein DinJ 284467 914340 ECs0253 Escherichia coli O157:H7 str. Sakai protein DinJ NP_308280.1 284207 R 386585 CDS NP_308281.1 15829508 914343 284677..285426 1 NC_002695.1 similar to YAFL_ECOLI gi|1786421 (conserved in Escherichia coli K-12); lipoprotein 285426 914343 ECs0254 Escherichia coli O157:H7 str. Sakai lipoprotein NP_308281.1 284677 D 386585 CDS NP_308282.1 15829509 914344 285602..285898 1 NC_002695.1 similar to N-terminal part (1-98 in 165 aa) of YAFM_ECOLI gi|1786422; hypothetical protein 285898 914344 ECs0255 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308282.1 285602 D 386585 CDS NP_308283.1 15829510 914346 complement(286244..287983) 1 NC_002695.1 similar to FHIA_ECOLI gi|1786423 (conserved in Escherichia coli K-12); FhiA protein 287983 914346 ECs0257 Escherichia coli O157:H7 str. Sakai FhiA protein NP_308283.1 286244 R 386585 CDS NP_308284.1 15829511 914347 287928..288713 1 NC_002695.1 similar to MBHA_ECOLI gi|1786424 (conserved in Escherichia coli K-12); hypothetical protein 288713 914347 ECs0256 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308284.1 287928 D 386585 CDS NP_308285.1 15829512 914349 288784..289839 1 NC_002695.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 289839 914349 ECs0258 Escherichia coli O157:H7 str. Sakai DNA polymerase IV NP_308285.1 288784 D 386585 CDS NP_308286.1 15829513 914352 289891..290184 1 NC_002695.1 similar to YAFN_ECOLI gi|1786426 (conserved in Escherichia coli K-12); antitoxin of the YafO-YafN toxin-antitoxin system 290184 914352 ECs0259 Escherichia coli O157:H7 str. Sakai antitoxin of the YafO-YafN toxin-antitoxin system NP_308286.1 289891 D 386585 CDS NP_308287.1 15829514 914353 290187..290585 1 NC_002695.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 290585 914353 ECs0260 Escherichia coli O157:H7 str. Sakai toxin YafO NP_308287.1 290187 D 386585 CDS NP_308288.1 15829515 914355 290595..291047 1 NC_002695.1 similar to YAFP_ECOLI gi|1786428 (conserved in Escherichia coli K-12); hypothetical protein 291047 914355 ECs0261 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308288.1 290595 D 386585 CDS NP_308289.1 15829516 914358 291354..291620 1 NC_002695.1 similar to B0235_ECOLI gi|1786430 (conserved in Escherichia coli K-12); hypothetical protein 291620 914358 ECs0262 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308289.1 291354 D 386585 CDS NP_308290.1 15829517 914361 291589..292089 1 NC_002695.1 similar to release factor 1 and 2; peptide chain release factor-like protein 292089 prfH 914361 prfH Escherichia coli O157:H7 str. Sakai peptide chain release factor-like protein NP_308290.1 291589 D 386585 CDS NP_308291.1 15829518 914362 complement(292146..293603) 1 NC_002695.1 similar to PEPD_ECOLI gi|1786432 (conserved in Escherichia coli K-12); hypothetical protein 293603 914362 ECs0264 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308291.1 292146 R 386585 CDS NP_308292.1 15829519 914363 293864..294322 1 NC_002695.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 294322 914363 ECs0265 Escherichia coli O157:H7 str. Sakai xanthine-guanine phosphoribosyltransferase NP_308292.1 293864 D 386585 CDS NP_308293.1 15829520 914364 294414..295658 1 NC_002695.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 295658 frsA 914364 frsA Escherichia coli O157:H7 str. Sakai fermentation/respiration switch protein NP_308293.1 294414 D 386585 CDS NP_308294.1 15829521 914365 295716..296117 1 NC_002695.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 296117 914365 ECs0267 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator Crl NP_308294.1 295716 D 386585 CDS NP_308295.1 15829522 914366 complement(296156..297211) 1 NC_002695.1 outer membrane pore protein; similar to PHOE_ECOLI gi|1786436 (conserved in Escherichia coli K-12); outer membrane phosphoporin protein E 297211 914366 ECs0268 Escherichia coli O157:H7 str. Sakai outer membrane phosphoporin protein E NP_308295.1 296156 R 386585 CDS NP_308296.1 15829523 914367 297499..298602 1 NC_002695.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 298602 914367 ECs0269 Escherichia coli O157:H7 str. Sakai gamma-glutamyl kinase NP_308296.1 297499 D 386585 CDS NP_308297.1 15829524 914368 298614..299867 1 NC_002695.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 299867 proA 914368 proA Escherichia coli O157:H7 str. Sakai gamma-glutamyl phosphate reductase NP_308297.1 298614 D 386585 CDS NP_308298.1 15829525 914370 complement(300072..301046) 1 NC_002695.1 similar to integrases e.g. [Shigella flexneri bacteriophage V] gi|2465477|gb|AAB72135.1; integrase 301046 914370 ECs0271 Escherichia coli O157:H7 str. Sakai integrase NP_308298.1 300072 R 386585 CDS NP_308299.1 15829526 914371 complement(300937..301182) 1 NC_002695.1 similar to transcription antitermination protein N [Bacteriophage lambda] gi|73111|pir||VNBPL; transcription antitermination protein 301182 914371 ECs0272 Escherichia coli O157:H7 str. Sakai transcription antitermination protein NP_308299.1 300937 R 386585 CDS NP_308300.1 15829527 914372 complement(301422..301811) 1 NC_002695.1 similar to N-terminal part of hypothetical proteins HP1334 [Helicobacter pylori (strain 26695)] gi|7464516|pir||F64686, hypothetical protein [Neisseria meningitidis] gi|6900422|e; hypothetical protein 301811 914372 ECs0273 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308300.1 301422 R 386585 CDS NP_308301.1 15829528 914373 complement(301939..302652) 1 NC_002695.1 similar to prophage repressor CI e.g. [Bacteriophage HK97] gi|6901592|gb|AAF31095.1|AF069529_8 (AF069529); hypothetical protein 302652 914373 ECs0274 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308301.1 301939 R 386585 CDS NP_308302.1 15829529 914374 302753..302953 1 NC_002695.1 similar to regulatory protein Cro [phage lambda] gi|73101|pir||RCBPL, similar toCro proteins e.g. [Bacteriophage HK97] gi|6901626|gb|AAF31129.1; Cro 302953 914374 ECs0275 Escherichia coli O157:H7 str. Sakai Cro NP_308302.1 302753 D 386585 CDS NP_308303.1 15829530 914375 303072..303365 1 NC_002695.1 regulatory protein; similar to regulatory protein cII [Bacteriophage lambda] gi|73106|pir||QCBP2L; hypothetical protein 303365 914375 ECs0276 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308303.1 303072 D 386585 CDS NP_308307.1 15829534 914379 304628..305422 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage HK97] gi|6901608|gb|AAF31111.1| (AF069529); Sc/SvQ proteins (DNA inversion product) [Escherichia coli plasmid p15B]; tail fiber protein 305422 914379 ECs0280 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_308307.1 304628 D 386585 CDS NP_308308.1 15829535 914380 305422..306015 1 NC_002695.1 similar to hypothetical proteins e.g. YcfA protein [Escherichia coli] gi|2506641|sp|P09153|YCFA_ECOLI; Gp29 [Bacteriophage HK97] gi|6901609|gb|AAF31112.1; T protein [Escherichia col; hypothetical protein 306015 914380 ECs0281 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308308.1 305422 D 386585 CDS NP_308309.1 15829536 914381 complement(305987..306430) 1 NC_002695.1 similar to hypothetical proteins e.g. YfdK [Escherichia coli(strain K-12)] gi|3915468|sp|P77656|YFDK_ECOLI; hypothetical protein 306430 914381 ECs0282 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308309.1 305987 R 386585 CDS NP_308310.1 15829537 914382 complement(306451..306861) 1 NC_002695.1 similar to hypothetical proteins e.g. YfdL [Escherichia coli (strain K-12)] gi|2495635|sp|P76508|YFDL_ECOLI; tail fiber protein YcfE [Escherichia coli cryptic prophage e14] gi|7444558|p; tail fiber protein 306861 914382 ECs0283 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_308310.1 306451 R 386585 CDS NP_308311.1 15829538 914383 306891..307445 1 NC_002695.1 similar to DNA-invertases e.g. Pin [Escherichia coli] gi|72978|pir||JWEC; DNA-invertase 307445 914383 ECs0284 Escherichia coli O157:H7 str. Sakai DNA-invertase NP_308311.1 306891 D 386585 CDS NP_308312.1 15829539 914384 complement(307503..308276) 1 NC_002695.1 similar to hypothetical protein [Deinococcus radiodurans (strain R1)] gi|7472205|pir||B75431; hypothetical protein 308276 914384 ECs0285 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308312.1 307503 R 386585 CDS NP_308314.1 15829541 914386 309100..309843 1 NC_002695.1 similar to transcription regulators e.g. AraC family transcriptional regulator YdeO gi|6176587|sp|P76135|YDEO_ECOLI; transcriptional regulator 309843 914386 ECs0287 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308314.1 309100 D 386585 CDS NP_308315.1 15829542 914387 complement(309885..310238) 1 NC_002695.1 similar to C-terminal parts of hypothetical proteins e.g. [Escherichia coli insertion sequence IS2] gi|140808|sp|P19777|YI22_ECOLI; may be disrupted; hypothetical protein 310238 914387 ECs0288 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308315.1 309885 R 386585 CDS NP_308316.1 15829543 914388 310806..311987 1 NC_002695.1 similar to integrases e.g. [phage phi-R73] gi|93827|pir||A42465; integrase 311987 914388 ECs0289 Escherichia coli O157:H7 str. Sakai integrase NP_308316.1 310806 D 386585 CDS NP_308317.1 15829544 914389 311991..312407 1 NC_002695.1 hypothetical protein 312407 914389 ECs0290 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308317.1 311991 D 386585 CDS NP_308318.1 15829545 914390 312380..312997 1 NC_002695.1 hypothetical protein 312997 914390 ECs0291 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308318.1 312380 D 386585 CDS NP_308319.1 15829546 914391 312997..313455 1 NC_002695.1 hypothetical protein 313455 914391 ECs0292 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308319.1 312997 D 386585 CDS NP_308320.1 15829547 914392 313448..314080 1 NC_002695.1 hypothetical protein 314080 914392 ECs0293 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308320.1 313448 D 386585 CDS NP_308321.1 15829548 914393 314111..314701 1 NC_002695.1 similar to hypothetical protein PFB0765w [malaria parasite] gi|7494317|pir||E71606; hypothetical protein 314701 914393 ECs0294 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308321.1 314111 D 386585 CDS NP_308322.1 15829549 914394 314701..315267 1 NC_002695.1 hypothetical protein 315267 914394 ECs0295 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308322.1 314701 D 386585 CDS NP_308323.1 15829550 914395 complement(315677..315949) 1 NC_002695.1 probable transcription activator; similar to Ogr family e.g. LsrS [Rahnella aquatilis] gi|93826|pir||E42465; delta protein [phage phi-R73] gi|93826|pir||E42465; Ogr family transcription activator 315949 914395 ECs0296 Escherichia coli O157:H7 str. Sakai Ogr family transcription activator NP_308323.1 315677 R 386585 CDS NP_308324.1 15829551 914396 complement(315955..316506) 1 NC_002695.1 probable polarity suppression protein (amber mutation-suppression protein); similar to Psu like proteins e.g. Psu [Bacteriophage P4] gi|1351414|sp|P05460|VPSU_BPP4; polarity suppression protein 316506 914396 ECs0297 Escherichia coli O157:H7 str. Sakai polarity suppression protein NP_308324.1 315955 R 386585 CDS NP_308325.1 15829552 914397 complement(316503..317255) 1 NC_002695.1 head size determination, similar to head size determination proteins e.g. Sid [phage phi-R73] gi|93821|pir||F42465; head size determination protein 317255 914397 ECs0298 Escherichia coli O157:H7 str. Sakai head size determination protein NP_308325.1 316503 R 386585 CDS NP_944502.1 38703851 2693817 317658..317828 1 NC_002695.1 hypothetical protein 317828 2693817 ECs5374 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944502.1 317658 D 386585 CDS NP_308326.1 15829553 914398 318189..318449 1 NC_002695.1 probable DNA binding protein, similar to hypothetical proteins e.g. DNA binding protein ORF88 [satellite phage P4] gi|140147|sp|P12552|Y9K_BPP4; DNA binding protein 318449 914398 ECs0299 Escherichia coli O157:H7 str. Sakai DNA binding protein NP_308326.1 318189 D 386585 CDS NP_308327.1 15829554 914399 318446..319003 1 NC_002695.1 similar to CI repressors e.g. [Bacteriophage P4] gi|1262833|emb|CAA35902.1; CI repressor 319003 914399 ECs0300 Escherichia coli O157:H7 str. Sakai CI repressor NP_308327.1 318446 D 386585 CDS NP_308328.1 15829555 914400 319000..319221 1 NC_002695.1 hypothetical protein 319221 914400 ECs0301 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308328.1 319000 D 386585 CDS NP_308329.1 15829556 914401 319221..319544 1 NC_002695.1 copy number control protein; similar to orf106 [satellite phage P4] gi|75896|pir||QQBPP4; Cnr-like protein 319544 914401 ECs0302 Escherichia coli O157:H7 str. Sakai Cnr-like protein NP_308329.1 319221 D 386585 CDS NP_308330.1 15829557 914402 319558..321891 1 NC_002695.1 similar to DNA primases e.g. alpha gene product [satellite phage P4] gi|130905|sp|P10277|PRIM_BPP4; DNA primase 321891 914402 ECs0303 Escherichia coli O157:H7 str. Sakai DNA primase NP_308330.1 319558 D 386585 CDS NP_308331.1 15829558 914403 complement(322024..322980) 1 NC_002695.1 similar to hypothetical protein sll1401 [Synechocystis sp. (strain PCC 6803)] gi|7470073|pir||S74462; hypothetical protein 322980 914403 ECs0304 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308331.1 322024 R 386585 CDS NP_308332.1 15829559 914404 complement(323656..324405) 1 NC_002695.1 similar to YAGP_ECOLI gi|1786476; hypothetical protein 324405 914404 ECs0305 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308332.1 323656 R 386585 CDS NP_308333.1 15829560 914405 324654..325376 1 NC_002695.1 similar to oxidoreductases e.g. [Streptomyces coelicolor A3(2)] gi|6137024|emb|CAB59579.1; oxidoreductase 325376 914405 ECs0306 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_308333.1 324654 D 386585 CDS NP_308334.1 15829561 914406 325543..325821 1 NC_002695.1 hypothetical protein 325821 914406 ECs0307 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308334.1 325543 D 386585 CDS NP_308336.1 15829563 914408 complement(326524..327426) 1 NC_002695.1 similar to transcriptional regulators e.g. [Xylella fastidiosa] gi|9106842|gb|AAF84577.1|AE003999_5; transcriptional regulator 327426 914408 ECs0309 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308336.1 326524 R 386585 CDS NP_308337.1 15829564 914409 327594..328730 1 NC_002695.1 similar to hypothetical protein [Pseudomonas aeruginosa] gi|732227|sp|Q01609|YODE_PSEAE; hypothetical protein 328730 914409 ECs0310 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308337.1 327594 D 386585 CDS NP_308338.1 15829565 914410 328806..329999 1 NC_002695.1 similar to transporters e.g. OpdE [Pseudomonas aeruginosa] gi|400678|sp|Q01602|OPDE_PSEAE; transporter 329999 914410 ECs0311 Escherichia coli O157:H7 str. Sakai transporter NP_308338.1 328806 D 386585 CDS NP_308340.1 15829567 914412 complement(330178..331134) 1 NC_002695.1 similar to YAGQ_ECOLI gi|1786477 (conserved in Escherichia coli K-12); hypothetical protein 331134 914412 ECs0313 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308340.1 330178 R 386585 CDS NP_308341.1 15829568 914413 complement(331144..333342) 1 NC_002695.1 similar to YAGR_ECOLI gi|1786478 (conserved in Escherichia coli K-12); hypothetical protein 333342 914413 ECs0314 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308341.1 331144 R 386585 CDS NP_308342.1 15829569 914414 complement(333339..334295) 1 NC_002695.1 similar to YAGS_ECOLI gi|1786479 (conserved in Escherichia coli K-12); hypothetical protein 334295 914414 ECs0315 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308342.1 333339 R 386585 CDS NP_308343.1 15829570 914415 complement(334292..334981) 1 NC_002695.1 similar to YAGT_ECOLI gi|1786480 (conserved in Escherichia coli K-12); xanthine dehydrogenase iron-sulfur-binding subunit 334981 914415 ECs0316 Escherichia coli O157:H7 str. Sakai xanthine dehydrogenase iron-sulfur-binding subunit NP_308343.1 334292 R 386585 CDS NP_308344.1 15829571 914416 335399..336013 1 NC_002695.1 similar to YAGU_ECOLI gi|1786481 (conserved in Escherichia coli K-12); hypothetical protein 336013 914416 ECs0317 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308344.1 335399 D 386585 CDS NP_308345.1 15829572 914417 complement(336261..336590) 1 NC_002695.1 similar to YKGJ_ECOLI gi|2367105 (conserved in Escherichia coli K-12); ferredoxin 336590 914417 ECs0318 Escherichia coli O157:H7 str. Sakai ferredoxin NP_308345.1 336261 R 386585 CDS NP_308346.1 15829573 914418 complement(336903..337658) 1 NC_002695.1 similar to YAGV_ECOLI gi|1786482 (conserved in Escherichia coli K-12); hypothetical protein 337658 914418 ECs0319 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308346.1 336903 R 386585 CDS NP_308347.1 15829574 914419 complement(337582..339225) 1 NC_002695.1 similar to YAGW_ECOLI gi|1786483 (conserved in Escherichia coli K-12); receptor 339225 914419 ECs0320 Escherichia coli O157:H7 str. Sakai receptor NP_308347.1 337582 R 386585 CDS NP_308348.1 15829575 914420 complement(339215..341740) 1 NC_002695.1 similar to YAGX_ECOLI gi|1786484 (conserved in Escherichia coli K-12); hypothetical protein 341740 914420 ECs0321 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308348.1 339215 R 386585 CDS NP_308349.1 15829576 914421 complement(341766..342434) 1 NC_002695.1 similar to YAGY_ECOLI gi|1786485 (conserved in Escherichia coli K-12); hypothetical protein 342434 914421 ECs0322 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308349.1 341766 R 386585 CDS NP_308350.1 15829577 914422 complement(342492..343079) 1 NC_002695.1 similar to YAGZ_ECOLI gi|1786486 (conserved in Escherichia coli K-12); hypothetical protein 343079 914422 ECs0323 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308350.1 342492 R 386585 CDS NP_308351.1 15829578 914423 complement(343154..343744) 1 NC_002695.1 similar to YKGK_ECOLI gi|2367106 (conserved in Escherichia coli K-12); regulator 343744 914423 ECs0324 Escherichia coli O157:H7 str. Sakai regulator NP_308351.1 343154 R 386585 CDS NP_308353.1 15829580 914425 344521..344712 1 NC_002695.1 similar to YKGL_ECOLI gi|2367107 (conserved in Escherichia coli K-12); hypothetical protein 344712 914425 ECs0326 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308353.1 344521 D 386585 CDS NP_944503.1 38703852 2693818 complement(344782..344922) 1 NC_002695.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 344922 rpmJ 2693818 rpmJ Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L36 NP_944503.1 344782 R 386585 CDS NP_308354.1 15829581 914426 complement(344922..345185) 1 NC_002695.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 345185 rpmE2 914426 rpmE2 Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L31 NP_308354.1 344922 R 386585 CDS NP_308355.1 15829582 914427 345428..345829 1 NC_002695.1 similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933}] gi|3414881|gb|AAC31492.1; hypothetical protein 345829 914427 ECs0328 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308355.1 345428 D 386585 CDS NP_308356.1 15829583 914428 345826..346173 1 NC_002695.1 similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933}] gi|3288157|emb|CAA11510.1; hypothetical protein 346173 914428 ECs0329 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308356.1 345826 D 386585 CDS NP_308357.1 15829584 914429 346223..347761 1 NC_002695.1 similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933}] gi|3414883|gb|AAC31494.1; hypothetical protein 347761 914429 ECs0330 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308357.1 346223 D 386585 CDS NP_308358.1 15829585 914430 complement(348573..349715) 1 NC_002695.1 similar to YqiG [Bacillus subtilis] gi|1731054|sp|P54524|YQIG_BACSU; NADH-dependent flavin oxidoreductase 349715 914430 ECs0331 Escherichia coli O157:H7 str. Sakai NADH-dependent flavin oxidoreductase NP_308358.1 348573 R 386585 CDS NP_308359.1 15829586 914431 complement(349950..350870) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli K-12] gi|3183244|sp|P76049|YCJY_ECOLI; hypothetical protein 350870 914431 ECs0332 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308359.1 349950 R 386585 CDS NP_308360.1 15829587 914432 351027..351953 1 NC_002695.1 similar to transcriptional regulators e.g. [Escherichia coli] gi|2495398|sp|P75836|YCAN_ECOLI; transcriptional regulator 351953 914432 ECs0333 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308360.1 351027 D 386585 CDS NP_308361.1 15829588 914433 complement(352241..352597) 1 NC_002695.1 hypothetical protein 352597 914433 ECs0334 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308361.1 352241 R 386585 CDS NP_308362.1 15829589 914434 complement(352790..353365) 1 NC_002695.1 similar to oxidoreductase, [Thermotoga maritima] gi|7431104|pir||A72308; oxidoreductase 353365 914434 ECs0335 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_308362.1 352790 R 386585 CDS NP_308363.1 15829590 914435 353931..358184 1 NC_002695.1 similar to probable membrane protein b1978 [Escherichia coli] gi|7466779|pir||D64962; similar toinvasins e.g. [Yersinia pestis] gi|726319|gb|AAA96352.1; invasin 358184 914435 ECs0336 Escherichia coli O157:H7 str. Sakai invasin NP_308363.1 353931 D 386585 CDS NP_308364.1 15829591 914436 complement(358305..359195) 1 NC_002695.1 similar to probable transcription regulator YkgA [Escherichia coli] gi|2495375|sp|P77601|YKGA_ECOLI; transcriptional regulator 359195 914436 ECs0337 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308364.1 358305 R 386585 CDS NP_308365.2 38703853 914437 359396..360280 1 NC_002695.1 similar to reductases e.g. oxidoreductase [Thermotoga maritima] gi|7431104|pir||A72308; reductase 360280 914437 ECs0338 Escherichia coli O157:H7 str. Sakai reductase NP_308365.2 359396 D 386585 CDS NP_308366.1 15829593 914438 complement(360440..361033) 1 NC_002695.1 similar to YKGB_ECOLI gi|1786492 (conserved in Escherichia coli K-12); hypothetical protein 361033 914438 ECs0340 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308366.1 360440 R 386585 CDS NP_308368.1 15829595 914440 complement(361045..361296) 1 NC_002695.1 similar to YKGI_ECOLI gi|1786494 (conserved in Escherichia coli K-12); hypothetical protein 361296 914440 ECs0341 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308368.1 361045 R 386585 CDS NP_308369.2 162139812 914441 complement(361390..362715) 1 NC_002695.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 362715 914441 ECs0342 Escherichia coli O157:H7 str. Sakai pyridine nucleotide-disulfide oxidoreductase NP_308369.2 361390 R 386585 CDS NP_308370.1 15829597 914442 362941..363795 1 NC_002695.1 similar to YKGD_ECOLI gi|1786496 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 363795 914442 ECs0343 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_308370.1 362941 D 386585 CDS NP_308371.1 15829598 914443 364322..365041 1 NC_002695.1 similar to YKGE_ECOLI gi|1786497 (conserved in Escherichia coli K-12); dehydrogenase subunit 365041 914443 ECs0344 Escherichia coli O157:H7 str. Sakai dehydrogenase subunit NP_308371.1 364322 D 386585 CDS NP_308372.1 15829599 914444 365052..366479 1 NC_002695.1 similar to YKGF_ECOLI gi|1786498 (conserved in Escherichia coli K-12); hypothetical protein 366479 914444 ECs0345 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308372.1 365052 D 386585 CDS NP_308373.2 38703854 914446 366472..367167 1 NC_002695.1 similar to YKGG_ECOLI gi|1786499 (conserved in Escherichia coli K-12); hypothetical protein 367167 914446 ECs0346 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308373.2 366472 D 386585 CDS NP_308374.1 15829601 914447 complement(367122..367334) 1 NC_002695.1 similar to B0309_ECOLI gi|1786500 (conserved in Escherichia coli K-12); hypothetical protein 367334 914447 ECs0347 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308374.1 367122 R 386585 CDS NP_308375.1 15829602 914448 complement(367662..368078) 1 NC_002695.1 similar to YKGH_ECOLI gi|1786502; hypothetical protein 368078 914448 ECs0348 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308375.1 367662 R 386585 CDS NP_308376.1 15829603 914449 complement(368260..368508) 1 NC_002695.1 similar to hypothetical protein YaiU [Escherichia coli] gi|2495526|sp|P75700|YAIU_ECOLI; hypothetical protein 368508 914449 ECs0349 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308376.1 368260 R 386585 CDS NP_308377.1 15829604 914451 complement(368426..369520) 1 NC_002695.1 similar to high molecular weight adhesin e.g. HmwA [Haemophilus influenzae] gi|5929966|gb|AAD56660.1|AF180944_1; adhesin 369520 914451 ECs0350 Escherichia coli O157:H7 str. Sakai adhesin NP_308377.1 368426 R 386585 CDS NP_308378.1 15829605 914452 complement(369562..370323) 1 NC_002695.1 hypothetical protein 370323 914452 ECs0351 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308378.1 369562 R 386585 CDS NP_308379.1 15829606 914453 complement(370477..370848) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|2506596|sp|P21514|YAHA_ECOLI; similar to regulators e.g. BvgA [Bordetella bronchiseptic] gi|115157|sp|P16574|BVGA_BORPE; hypothetical protein 370848 914453 ECs0352 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308379.1 370477 R 386585 CDS NP_308380.1 15829607 914454 complement(371104..371271) 1 NC_002695.1 hypothetical protein 371271 914454 ECs0353 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308380.1 371104 R 386585 CDS NP_944504.1 38703855 2693819 372970..373221 1 NC_002695.1 hypothetical protein 373221 2693819 ECs5376 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944504.1 372970 D 386585 CDS NP_308384.1 15829611 914458 complement(373223..374911) 1 NC_002695.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 374911 914458 ECs0357 Escherichia coli O157:H7 str. Sakai choline dehydrogenase NP_308384.1 373223 R 386585 CDS NP_308385.1 15829612 914459 complement(374925..376397) 1 NC_002695.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 376397 914459 ECs0358 Escherichia coli O157:H7 str. Sakai betaine aldehyde dehydrogenase NP_308385.1 374925 R 386585 CDS NP_308386.2 38703856 914460 complement(376411..377016) 1 NC_002695.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 377016 914460 ECs0359 Escherichia coli O157:H7 str. Sakai transcriptional regulator BetI NP_308386.2 376411 R 386585 CDS NP_308387.1 15829614 914461 377127..379160 1 NC_002695.1 proton-motive-force-driven choline transporter; choline transport protein BetT 379160 914461 ECs0360 Escherichia coli O157:H7 str. Sakai choline transport protein BetT NP_308387.1 377127 D 386585 CDS NP_308389.1 15829616 914463 379734..383717 1 NC_002695.1 similar to IgA1 protease homolog MisL [Salmonella typhimurium pathogenicity island SPI-3] gi|4324610|gb|AAD16954.1|; similar to VirG [Shigella flexneri] gi|96922|pir||A32247; probable adhesin; AidA-I adhesin precursor e.g. [Escherichia coli plasmid F] gi|8918851|dbj|BAA97898.1; AidA-I adhesin-like protein 383717 914463 ECs0362 Escherichia coli O157:H7 str. Sakai AidA-I adhesin-like protein NP_308389.1 379734 D 386585 CDS NP_308390.1 15829617 914464 383859..384947 1 NC_002695.1 similar to YAHA_ECOLI gi|1786507 (conserved in Escherichia coli K-12); hypothetical protein 384947 914464 ECs0363 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308390.1 383859 D 386585 CDS NP_308393.1 15829620 914467 complement(386012..386314) 1 NC_002695.1 similar to YAHC_ECOLI gi|1786509 (conserved in Escherichia coli K-12); hypothetical protein 386314 914467 ECs0366 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308393.1 386012 R 386585 CDS NP_308394.1 15829621 914468 386777..387382 1 NC_002695.1 similar to YAHD_ECOLI gi|1786511 (conserved in Escherichia coli K-12); transcription factor 387382 914468 ECs0367 Escherichia coli O157:H7 str. Sakai transcription factor NP_308394.1 386777 D 386585 CDS NP_308395.1 15829622 914469 387422..388285 1 NC_002695.1 similar to YAHE_ECOLI gi|1786512 (conserved in Escherichia coli K-12); hypothetical protein 388285 914469 ECs0368 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308395.1 387422 D 386585 CDS NP_308396.1 15829623 914470 388275..389822 1 NC_002695.1 similar to YAHF_ECOLI gi|1786513 (conserved in Escherichia coli K-12); oxidoreductase subunit 389822 914470 ECs0369 Escherichia coli O157:H7 str. Sakai oxidoreductase subunit NP_308396.1 388275 D 386585 CDS NP_308397.1 15829624 914471 389822..391240 1 NC_002695.1 similar to YAHG_ECOLI gi|1786514 (conserved in Escherichia coli K-12); hypothetical protein 391240 914471 ECs0370 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308397.1 389822 D 386585 CDS NP_308398.1 15829625 914472 391266..391586 1 NC_002695.1 similar to YAHH_ECOLI gi|1786515 (conserved in Escherichia coli K-12); hypothetical protein 391586 914472 ECs0371 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308398.1 391266 D 386585 CDS NP_308399.1 15829626 914473 391755..392705 1 NC_002695.1 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 392705 914473 ECs0372 Escherichia coli O157:H7 str. Sakai carbamate kinase NP_308399.1 391755 D 386585 CDS NP_308400.1 15829627 914474 392715..394097 1 NC_002695.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 394097 914474 ECs0373 Escherichia coli O157:H7 str. Sakai deaminase NP_308400.1 392715 D 386585 CDS NP_944505.1 38703857 2693814 394366..394806 1 NC_002695.1 hypothetical protein 394806 2693814 ECs5377 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944505.1 394366 D 386585 CDS NP_308401.1 15829628 914475 395057..396043 1 NC_002695.1 similar to sugar-binding proteins e.g. b1516 [Escherichia coli] gi|7466925|pir||G64905; sugar-binding protein 396043 914475 ECs0374 Escherichia coli O157:H7 str. Sakai sugar-binding protein NP_308401.1 395057 D 386585 CDS NP_308402.1 15829629 914476 396092..396352 1 NC_002695.1 similar to N-terminal part of ABC transporter ATP-binding proteins e.g. [Streptomyces coelicolor A3(2)] gi|7479110|pir||T34924; ABC transporter ATP-binding protein 396352 914476 ECs0375 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308402.1 396092 D 386585 CDS NP_308403.1 15829630 914477 396464..397576 1 NC_002695.1 similar to C-terminal part of sugar ABC transporter ATP-binding proteins e.g. [Bacillus subtilis] gi|7404442|sp|P36947|RBSA_BACSU; ABC transporter ATP-binding protein 397576 914477 ECs0376 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308403.1 396464 D 386585 CDS NP_308404.1 15829631 914478 397569..398540 1 NC_002695.1 similar to ABC transporter permeases e.g. RbsC[Bacillus subtilis] gi|7446897|pir||B69690; [Escherichia coli] gi|400960|sp|P04984|RBSC_ECOLI; ABC transporter permease 398540 914478 ECs0377 Escherichia coli O157:H7 str. Sakai ABC transporter permease NP_308404.1 397569 D 386585 CDS NP_308405.1 15829632 914479 398537..399493 1 NC_002695.1 similar to ABC transporter permeases e.g. RbsC [Escherichia coli] gi|78833|pir||C26304; [Bacillus subtilis] gi|7446897|pir||B69690; ABC transporter permease 399493 914479 ECs0378 Escherichia coli O157:H7 str. Sakai ABC transporter permease NP_308405.1 398537 D 386585 CDS NP_308406.1 15829633 914480 399580..400629 1 NC_002695.1 similar to YAHK_ECOLI gi|1786518 (conserved in Escherichia coli K-12); oxidoreductase 400629 914480 ECs0379 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_308406.1 399580 D 386585 CDS NP_308407.1 15829634 914481 400872..401687 1 NC_002695.1 similar to YAHL_ECOLI gi|1786519 (conserved in Escherichia coli K-12); hypothetical protein 401687 914481 ECs0380 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308407.1 400872 D 386585 CDS NP_308409.2 38703858 914484 complement(402365..403012) 1 NC_002695.1 similar to YAHN_ECOLI gi|1786522 (conserved in Escherichia coli K-12); cytochrome subunit of dehydrogenase 403012 914484 ECs0382 Escherichia coli O157:H7 str. Sakai cytochrome subunit of dehydrogenase NP_308409.2 402365 R 386585 CDS NP_308410.1 15829637 914485 403183..403458 1 NC_002695.1 similar to YAHO_ECOLI gi|1786523 (conserved in Escherichia coli K-12); hypothetical protein 403458 914485 ECs0383 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308410.1 403183 D 386585 CDS NP_308411.1 15829638 914486 complement(403556..405142) 1 NC_002695.1 similar to PRPR_ECOLI gi|1786524 (conserved in Escherichia coli K-12); regulator for prp operon 405142 914486 ECs0384 Escherichia coli O157:H7 str. Sakai regulator for prp operon NP_308411.1 403556 R 386585 CDS NP_308412.1 15829639 914487 405381..406271 1 NC_002695.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 406271 prpB 914487 prpB Escherichia coli O157:H7 str. Sakai 2-methylisocitrate lyase NP_308412.1 405381 D 386585 CDS NP_308413.1 15829640 914488 406427..407596 1 NC_002695.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 407596 914488 ECs0386 Escherichia coli O157:H7 str. Sakai methylcitrate synthase NP_308413.1 406427 D 386585 CDS NP_308414.1 15829641 914489 407630..409081 1 NC_002695.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 409081 prpD 914489 prpD Escherichia coli O157:H7 str. Sakai 2-methylcitrate dehydratase NP_308414.1 407630 D 386585 CDS NP_308415.1 15829642 914490 409121..411007 1 NC_002695.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 411007 prpE 914490 prpE Escherichia coli O157:H7 str. Sakai propionyl-CoA synthetase NP_308415.1 409121 D 386585 CDS NP_308416.1 15829643 914491 411901..413160 1 NC_002695.1 similar to CODB_ECOLI gi|1786530 (conserved in Escherichia coli K-12); cytosine permease 413160 codB 914491 codB Escherichia coli O157:H7 str. Sakai cytosine permease NP_308416.1 411901 D 386585 CDS NP_308417.1 15829644 914492 413150..414433 1 NC_002695.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 414433 914492 ECs0390 Escherichia coli O157:H7 str. Sakai cytosine deaminase NP_308417.1 413150 D 386585 CDS NP_308418.1 15829645 914493 complement(414566..415465) 1 NC_002695.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 415465 914493 ECs0391 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator CynR NP_308418.1 414566 R 386585 CDS NP_308419.1 15829646 914494 415575..416234 1 NC_002695.1 similar to CYNT_ECOLI gi|1786534 (conserved in Escherichia coli K-12); carbonic anhydrase 416234 914494 ECs0392 Escherichia coli O157:H7 str. Sakai carbonic anhydrase NP_308419.1 415575 D 386585 CDS NP_308420.1 15829647 914495 416265..416735 1 NC_002695.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 416735 914495 ECs0393 Escherichia coli O157:H7 str. Sakai cyanate hydratase NP_308420.1 416265 D 386585 CDS NP_308421.1 15829648 914496 416768..417922 1 NC_002695.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 417922 cynX 914496 cynX Escherichia coli O157:H7 str. Sakai cyanate transporter NP_308421.1 416768 D 386585 CDS NP_308422.1 15829649 914497 complement(418025..418636) 1 NC_002695.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 418636 lacA 914497 lacA Escherichia coli O157:H7 str. Sakai galactoside O-acetyltransferase NP_308422.1 418025 R 386585 CDS NP_308423.1 15829650 914498 complement(418702..419955) 1 NC_002695.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 419955 lacY 914498 lacY Escherichia coli O157:H7 str. Sakai galactoside permease NP_308423.1 418702 R 386585 CDS NP_308424.1 15829651 914499 complement(420007..423081) 1 NC_002695.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 423081 lacZ 914499 lacZ Escherichia coli O157:H7 str. Sakai beta-D-galactosidase NP_308424.1 420007 R 386585 CDS NP_308425.2 38703859 914500 complement(423204..424295) 1 NC_002695.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 424295 lacI 914500 lacI Escherichia coli O157:H7 str. Sakai lac repressor NP_308425.2 423204 R 386585 CDS NP_308426.1 15829653 914501 complement(424323..425276) 1 NC_002695.1 similar to araC-family transcriptional regulators e.g. AdpA [Streptomyces coelicolor A3(2)] gi|7544056|emb|CAB87229.1; transcriptional regulator 425276 914501 ECs0399 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308426.1 424323 R 386585 CDS NP_308427.1 15829654 914502 complement(425296..426084) 1 NC_002695.1 similar to YDDR_BACSU gi|7474951|pir||H69776; hypothetical protein 426084 914502 ECs0400 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308427.1 425296 R 386585 CDS NP_308428.1 15829655 914503 complement(426187..427134) 1 NC_002695.1 activator of 3-phenylpropionic acid catabolism; MhpR family transcriptional regulator 427134 914503 ECs0401 Escherichia coli O157:H7 str. Sakai MhpR family transcriptional regulator NP_308428.1 426187 R 386585 CDS NP_308429.1 15829656 914504 427211..428875 1 NC_002695.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 428875 mhpA 914504 mhpA Escherichia coli O157:H7 str. Sakai 3-(3-hydroxyphenyl)propionate hydroxylase NP_308429.1 427211 D 386585 CDS NP_308430.1 15829657 914505 428877..429821 1 NC_002695.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 429821 mhpB 914505 mhpB Escherichia coli O157:H7 str. Sakai 3-(2,3-dihydroxyphenyl)propionate dioxygenase NP_308430.1 428877 D 386585 CDS NP_308431.2 38703860 914506 429824..430705 1 NC_002695.1 similar to MHPC_ECOLI gi|1786545 (conserved in Escherichia coli K-12); 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 430705 914506 ECs0404 Escherichia coli O157:H7 str. Sakai 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase NP_308431.2 429824 D 386585 CDS NP_308432.1 15829659 914507 430715..431524 1 NC_002695.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 431524 mhpD 914507 mhpD Escherichia coli O157:H7 str. Sakai 2-keto-4-pentenoate hydratase NP_308432.1 430715 D 386585 CDS NP_308433.1 15829660 914508 431521..432471 1 NC_002695.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 432471 914508 ECs0406 Escherichia coli O157:H7 str. Sakai acetaldehyde dehydrogenase NP_308433.1 431521 D 386585 CDS NP_308434.1 15829661 914509 432468..433481 1 NC_002695.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 433481 914509 ECs0407 Escherichia coli O157:H7 str. Sakai 4-hydroxy-2-ketovalerate aldolase NP_308434.1 432468 D 386585 CDS NP_308435.2 162139811 914510 433657..434868 1 NC_002695.1 similar to MHPT_ECOLI gi|1786549 (conserved in Escherichia coli K-12); 3-hydroxyphenylpropionic transporter MhpT 434868 914510 ECs0408 Escherichia coli O157:H7 str. Sakai 3-hydroxyphenylpropionic transporter MhpT NP_308435.2 433657 D 386585 CDS NP_308436.2 162139810 914511 434970..435509 1 NC_002695.1 similar to YAIL_ECOLI gi|1786550 (conserved in Escherichia coli K-12); nucleoprotein/polynucleotide-associated enzyme 435509 914511 ECs0409 Escherichia coli O157:H7 str. Sakai nucleoprotein/polynucleotide-associated enzyme NP_308436.2 434970 D 386585 CDS NP_308437.1 15829664 914512 complement(435634..436467) 1 NC_002695.1 similar to YAIM_ECOLI gi|1786551 (conserved in Escherichia coli K-12); esterase 436467 914512 ECs0410 Escherichia coli O157:H7 str. Sakai esterase NP_308437.1 435634 R 386585 CDS NP_308438.1 15829665 914513 complement(436560..437669) 1 NC_002695.1 similar to ADHC_ECOLI gi|1786552 (conserved in Escherichia coli K-12); alcohol dehydrogenase 437669 914513 ECs0411 Escherichia coli O157:H7 str. Sakai alcohol dehydrogenase NP_308438.1 436560 R 386585 CDS NP_308439.3 162139706 914514 complement(437704..438000) 1 NC_002695.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 438000 914514 ECs0412 Escherichia coli O157:H7 str. Sakai regulator protein FrmR NP_308439.3 437704 R 386585 CDS NP_308440.2 162139809 914515 complement(438139..439185) 1 NC_002695.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding protein 439185 fbpC 914515 fbpC Escherichia coli O157:H7 str. Sakai ferric transporter ATP-binding protein NP_308440.2 438139 R 386585 CDS NP_308441.1 15829668 914516 complement(439197..441275) 1 NC_002695.1 similar to ferric transport system permeases e.g. AfuB [Actinobacillus pleuropneumoniae] gi|7387527|sp|Q44123|AFUB_ACTPL; ferric transport system permease 441275 914516 ECs0414 Escherichia coli O157:H7 str. Sakai ferric transport system permease NP_308441.1 439197 R 386585 CDS NP_308442.1 15829669 914517 complement(441344..442375) 1 NC_002695.1 similar to periplasmic-iron-binding proteins e.g. AfuA [Actinobacillus pleuropneumoniae] gi|1469286|gb|AAB05032.1; periplasmic-iron-binding protein 442375 914517 ECs0415 Escherichia coli O157:H7 str. Sakai periplasmic-iron-binding protein NP_308442.1 441344 R 386585 CDS NP_308443.1 15829670 914518 complement(442372..443676) 1 NC_002695.1 similar to hexosephosphate transport system regulatory proteins e.g. UhpC [Escherichia coli K-12] gi|136770|sp|P09836|UHPC_ECOLI; regulatory protein 443676 914518 ECs0416 Escherichia coli O157:H7 str. Sakai regulatory protein NP_308443.1 442372 R 386585 CDS NP_308444.1 15829671 914519 complement(443761..445302) 1 NC_002695.1 similar to sensor protein kinases e.g. hexosephosphate transport system sensor protein UhpB [Escherichia coli K-12] gi|7429062|pir||RGECUB; sensor histidine protein kinase 445302 914519 ECs0417 Escherichia coli O157:H7 str. Sakai sensor histidine protein kinase NP_308444.1 443761 R 386585 CDS NP_308445.1 15829672 914520 complement(445302..445931) 1 NC_002695.1 response regulator; similar to transcription regulators e.g. hexose phosphate transport system regulatory protein UhpA [Salmonella typhimurium] gi|136767|sp|P27667|UHPA_SALTY; transcriptional regulator 445931 914520 ECs0418 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308445.1 445302 R 386585 CDS NP_308446.1 15829673 914521 446234..447196 1 NC_002695.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 447196 tauA 914521 tauA Escherichia coli O157:H7 str. Sakai taurine transporter substrate binding subunit NP_308446.1 446234 D 386585 CDS NP_308447.1 15829674 914522 447209..447976 1 NC_002695.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding protein 447976 tauB 914522 tauB Escherichia coli O157:H7 str. Sakai taurine transporter ATP-binding protein NP_308447.1 447209 D 386585 CDS NP_308448.1 15829675 914523 447973..448800 1 NC_002695.1 similar to TAUC_ECOLI gi|1786564 (conserved in Escherichia coli K-12); taurine transporter subunit 448800 914523 ECs0421 Escherichia coli O157:H7 str. Sakai taurine transporter subunit NP_308448.1 447973 D 386585 CDS NP_308449.1 15829676 914524 448797..449648 1 NC_002695.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 449648 tauD 914524 tauD Escherichia coli O157:H7 str. Sakai taurine dioxygenase NP_308449.1 448797 D 386585 CDS NP_308450.2 38703862 914525 complement(449755..450729) 1 NC_002695.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 450729 914525 ECs0423 Escherichia coli O157:H7 str. Sakai delta-aminolevulinic acid dehydratase NP_308450.2 449755 R 386585 CDS NP_308451.1 15829678 914526 451255..454197 1 NC_002695.1 similar to YAIT_ECOLI gi|1786569 (conserved in Escherichia coli K-12); flagellin structural protein 454197 914526 ECs0424 Escherichia coli O157:H7 str. Sakai flagellin structural protein NP_308451.1 451255 D 386585 CDS NP_308452.1 15829679 914527 454240..454908 1 NC_002695.1 similar to YAIV_ECOLI gi|1786573 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 454908 914527 ECs0425 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_308452.1 454240 D 386585 CDS NP_308453.1 15829680 914528 complement(454909..456066) 1 NC_002695.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 456066 914528 ECs0426 Escherichia coli O157:H7 str. Sakai beta-lactam binding protein AmpH NP_308453.1 454909 R 386585 CDS NP_308454.1 15829681 914529 456418..457638 1 NC_002695.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 457638 914529 ECs0427 Escherichia coli O157:H7 str. Sakai transporter NP_308454.1 456418 D 386585 CDS NP_308455.1 15829682 914530 457651..458745 1 NC_002695.1 similar to YAIW_ECOLI gi|1786576 (conserved in Escherichia coli K-12); hypothetical protein 458745 914530 ECs0428 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308455.1 457651 D 386585 CDS NP_308456.1 15829683 914531 complement(458804..459112) 1 NC_002695.1 similar to B0379_ECOLI gi|1786577 (conserved in Escherichia coli K-12); hypothetical protein 459112 914531 ECs0429 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308456.1 458804 R 386585 CDS NP_308457.1 15829684 914532 459240..459584 1 NC_002695.1 similar to B0380_ECOLI gi|1786578 (conserved in Escherichia coli K-12); hypothetical protein 459584 914532 ECs0430 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308457.1 459240 D 386585 CDS NP_308458.1 15829685 914533 complement(459608..460702) 1 NC_002695.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 460702 ddl 914533 ddl Escherichia coli O157:H7 str. Sakai D-alanyl-alanine synthetase A NP_308458.1 459608 R 386585 CDS NP_308459.1 15829686 914534 461165..461425 1 NC_002695.1 similar to YAIB_ECOLI gi|1786581 (conserved in Escherichia coli K-12); hypothetical protein 461425 914534 ECs0432 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308459.1 461165 D 386585 CDS NP_308460.1 15829687 914535 461457..462941 1 NC_002695.1 similar to PHOA_ECOLI gi|1786582 (conserved in Escherichia coli K-12); alkaline phosphatase 462941 914535 ECs0433 Escherichia coli O157:H7 str. Sakai alkaline phosphatase NP_308460.1 461457 D 386585 CDS NP_308461.1 15829688 914536 463042..463380 1 NC_002695.1 similar to PSIF_ECOLI gi|1786583 (conserved in Escherichia coli K-12); hypothetical protein 463380 psiF 914536 psiF Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308461.1 463042 D 386585 CDS NP_308462.1 15829689 914537 463482..464597 1 NC_002695.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 464597 adrA 914537 adrA Escherichia coli O157:H7 str. Sakai diguanylate cyclase AdrA NP_308462.1 463482 D 386585 CDS NP_308463.1 15829690 914538 complement(464614..465423) 1 NC_002695.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 465423 proC 914538 proC Escherichia coli O157:H7 str. Sakai pyrroline-5-carboxylate reductase NP_308463.1 464614 R 386585 CDS NP_308464.2 162139808 914539 465543..466001 1 NC_002695.1 similar to YAII_ECOLI gi|1786586 (conserved in Escherichia coli K-12); hypothetical protein 466001 914539 ECs0436 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308464.2 465543 D 386585 CDS NP_308465.1 15829692 914540 466184..466708 1 NC_002695.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 466708 aroL 914540 aroL Escherichia coli O157:H7 str. Sakai shikimate kinase NP_308465.1 466184 D 386585 CDS NP_308466.1 15829693 914541 466758..466949 1 NC_002695.1 similar to YAIA_ECOLI gi|1786588 (conserved in Escherichia coli K-12); hypothetical protein 466949 914541 ECs0439 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308466.1 466758 D 386585 CDS NP_308467.1 15829694 914542 467207..467884 1 NC_002695.1 similar to AROM_ECOLI gi|1786589 (conserved in Escherichia coli K-12); hypothetical protein 467884 914542 ECs0440 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308467.1 467207 D 386585 CDS NP_308468.1 15829695 914543 467956..468240 1 NC_002695.1 similar to YAIE_ECOLI gi|1786590 (conserved in Escherichia coli K-12); hypothetical protein 468240 914543 ECs0441 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308468.1 467956 D 386585 CDS NP_308469.1 15829696 914544 470382..470663 1 NC_002695.1 similar to B0392_ECOLI gi|1786591 (conserved in Escherichia coli K-12); hypothetical protein 470663 914544 ECs0442 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308469.1 470382 D 386585 CDS NP_308470.1 15829697 914545 470660..471109 1 NC_002695.1 hypothetical protein 471109 914545 ECs0443 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308470.1 470660 D 386585 CDS NP_308471.1 15829698 914546 complement(471194..472105) 1 NC_002695.1 Required for efficient pilin antigenic variation; recombination associated protein 472105 rdgC 914546 rdgC Escherichia coli O157:H7 str. Sakai recombination associated protein NP_308471.1 471194 R 386585 CDS NP_308472.2 162139807 914547 472230..473138 1 NC_002695.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 473138 914547 ECs0444 Escherichia coli O157:H7 str. Sakai fructokinase NP_308472.2 472230 D 386585 CDS NP_308473.2 38703863 914548 complement(473281..474549) 1 NC_002695.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 474549 araJ 914548 araJ Escherichia coli O157:H7 str. Sakai MFS transport protein AraJ NP_308473.2 473281 R 386585 CDS NP_308474.1 15829701 914549 complement(474591..477734) 1 NC_002695.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 477734 914549 ECs0447 Escherichia coli O157:H7 str. Sakai exonuclease SbcC NP_308474.1 474591 R 386585 CDS NP_308475.1 15829702 914550 complement(477731..478933) 1 NC_002695.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD 478933 914550 ECs0448 Escherichia coli O157:H7 str. Sakai exonuclease SbcD NP_308475.1 477731 R 386585 CDS NP_308476.1 15829703 914551 479123..479812 1 NC_002695.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 479812 914551 ECs0449 Escherichia coli O157:H7 str. Sakai transcriptional regulator PhoB NP_308476.1 479123 D 386585 CDS NP_308477.1 15829704 914552 479870..481165 1 NC_002695.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 481165 phoR 914552 phoR Escherichia coli O157:H7 str. Sakai phosphate regulon sensor protein NP_308477.1 479870 D 386585 CDS NP_308478.1 15829705 914553 481572..482891 1 NC_002695.1 similar to BRNQ_ECOLI gi|1786601 (conserved in Escherichia coli K-12); branched-chain amino acid ABC transporter substrate-binding protein 482891 914553 ECs0451 Escherichia coli O157:H7 str. Sakai branched-chain amino acid ABC transporter substrate-binding protein NP_308478.1 481572 D 386585 CDS NP_308479.1 15829706 914554 482967..484340 1 NC_002695.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; permease 484340 proY 914554 proY Escherichia coli O157:H7 str. Sakai permease NP_308479.1 482967 D 386585 CDS NP_308480.1 15829707 914555 484496..486313 1 NC_002695.1 similar to MALZ_ECOLI gi|1786604 (conserved in Escherichia coli K-12); maltodextrin glucosidase 486313 914555 ECs0453 Escherichia coli O157:H7 str. Sakai maltodextrin glucosidase NP_308480.1 484496 D 386585 CDS NP_308481.1 15829708 914556 486501..487946 1 NC_002695.1 hypothetical protein 487946 914556 ECs0454 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308481.1 486501 D 386585 CDS NP_308482.1 15829709 914557 complement(487967..488548) 1 NC_002695.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase 488548 914557 ECs0455 Escherichia coli O157:H7 str. Sakai ACP phosphodieterase NP_308482.1 487967 R 386585 CDS NP_308483.1 15829710 914558 488641..489711 1 NC_002695.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 489711 queA 914558 queA Escherichia coli O157:H7 str. Sakai S-adenosylmethionine--tRNA ribosyltransferase-isomerase NP_308483.1 488641 D 386585 CDS NP_308484.1 15829711 914559 489766..490893 1 NC_002695.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 490893 tgt 914559 tgt Escherichia coli O157:H7 str. Sakai queuine tRNA-ribosyltransferase NP_308484.1 489766 D 386585 CDS NP_308485.1 15829712 914560 490916..491248 1 NC_002695.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 491248 yajC 914560 yajC Escherichia coli O157:H7 str. Sakai preprotein translocase subunit YajC NP_308485.1 490916 D 386585 CDS NP_308486.1 15829713 914561 491276..493123 1 NC_002695.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 493123 secD 914561 secD Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecD NP_308486.1 491276 D 386585 CDS NP_308487.1 15829714 914562 493134..494105 1 NC_002695.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 494105 secF 914562 secF Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecF NP_308487.1 493134 D 386585 CDS NP_308488.1 15829715 914563 494256..494498 1 NC_002695.1 similar to hypothetical protein [Yersinia enterocolitica] gi|3511032|gb|AAC33681.1; hypothetical protein 494498 914563 ECs0461 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308488.1 494256 D 386585 CDS NP_308489.1 15829716 914564 494491..494772 1 NC_002695.1 similar to hypothetical protein [Yersinia pestis] gi|3822096|gb|AAC69816.1; hypothetical protein 494772 914564 ECs0462 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308489.1 494491 D 386585 CDS NP_308490.1 15829717 914565 494860..495207 1 NC_002695.1 similar to YAJD_ECOLI gi|1786611 (conserved in Escherichia coli K-12); hypothetical protein 495207 914565 ECs0463 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308490.1 494860 D 386585 CDS NP_308491.1 15829718 914566 complement(495384..496268) 1 NC_002695.1 similar to TSX_ECOLI gi|1786612 (conserved in Escherichia coli K-12); nucleoside-specific channel-forming protein Tsx 496268 914566 ECs0464 Escherichia coli O157:H7 str. Sakai nucleoside-specific channel-forming protein Tsx NP_308491.1 495384 R 386585 CDS NP_308492.2 38703864 914567 complement(496567..497106) 1 NC_002695.1 similar to YAJI_ECOLI gi|1786613 (conserved in Escherichia coli K-12); hypothetical protein 497106 914567 ECs0465 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308492.2 496567 R 386585 CDS NP_308493.1 15829720 914568 497257..497706 1 NC_002695.1 similar to YBAD_ECOLI gi|1786615 (conserved in Escherichia coli K-12); transcriptional regulator NrdR 497706 nrdR 914568 nrdR Escherichia coli O157:H7 str. Sakai transcriptional regulator NrdR NP_308493.1 497257 D 386585 CDS NP_308494.1 15829721 914569 497710..498813 1 NC_002695.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 498813 ribD 914569 ribD Escherichia coli O157:H7 str. Sakai bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase NP_308494.1 497710 D 386585 CDS NP_308495.1 15829722 914570 498902..499372 1 NC_002695.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 499372 ribH 914570 ribH Escherichia coli O157:H7 str. Sakai 6,7-dimethyl-8-ribityllumazine synthase NP_308495.1 498902 D 386585 CDS NP_308496.1 15829723 914571 499392..499811 1 NC_002695.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 499811 nusB 914571 nusB Escherichia coli O157:H7 str. Sakai transcription antitermination protein NusB NP_308496.1 499392 D 386585 CDS NP_308497.1 15829724 914572 499889..500866 1 NC_002695.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 500866 914572 ECs0470 Escherichia coli O157:H7 str. Sakai thiamine monophosphate kinase NP_308497.1 499889 D 386585 CDS NP_308498.1 15829725 914573 500844..501359 1 NC_002695.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 501359 914573 ECs0471 Escherichia coli O157:H7 str. Sakai phosphatidylglycerophosphatase A NP_308498.1 500844 D 386585 CDS NP_308499.1 15829726 914574 complement(501537..503108) 1 NC_002695.1 hypothetical protein 503108 914574 ECs0472 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308499.1 501537 R 386585 CDS NP_308500.1 15829727 914575 complement(503339..504313) 1 NC_002695.1 similar to YJAO_ECOLI gi|1786621 (conserved in Escherichia coli K-12); NAD(P)H-dependent xylose reductase 504313 914575 ECs0473 Escherichia coli O157:H7 str. Sakai NAD(P)H-dependent xylose reductase NP_308500.1 503339 R 386585 CDS NP_308501.1 15829728 914576 complement(504368..506230) 1 NC_002695.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 506230 914576 ECs0474 Escherichia coli O157:H7 str. Sakai 1-deoxy-D-xylulose-5-phosphate synthase NP_308501.1 504368 R 386585 CDS NP_308502.1 15829729 914577 complement(506255..507154) 1 NC_002695.1 similar to ISPA_ECOLI gi|1786623 (conserved in Escherichia coli K-12); geranyltranstransferase 507154 914577 ECs0475 Escherichia coli O157:H7 str. Sakai geranyltranstransferase NP_308502.1 506255 R 386585 CDS NP_308503.1 15829730 914578 complement(507154..507396) 1 NC_002695.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 507396 914578 ECs0476 Escherichia coli O157:H7 str. Sakai exodeoxyribonuclease VII small subunit NP_308503.1 507154 R 386585 CDS NP_308504.1 15829731 914579 507602..509050 1 NC_002695.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 509050 914579 ECs0477 Escherichia coli O157:H7 str. Sakai thiamine biosynthesis protein ThiI NP_308504.1 507602 D 386585 CDS NP_308505.2 38703865 914580 complement(509104..509694) 1 NC_002695.1 similar to THIJ_ECOLI gi|1786626 (conserved in Escherichia coli K-12); DJ-1 family protein 509694 914580 ECs0478 Escherichia coli O157:H7 str. Sakai DJ-1 family protein NP_308505.2 509104 R 386585 CDS NP_308506.1 15829733 914581 complement(509657..510568) 1 NC_002695.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 510568 914581 ECs0479 Escherichia coli O157:H7 str. Sakai 2-dehydropantoate 2-reductase NP_308506.1 509657 R 386585 CDS NP_308507.2 162139806 914582 510736..511227 1 NC_002695.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 511227 914582 ECs0480 Escherichia coli O157:H7 str. Sakai nucleotide-binding protein NP_308507.2 510736 D 386585 CDS NP_308508.2 38703866 914583 complement(511355..512719) 1 NC_002695.1 similar to YAJR_ECOLI gi|1786630 (conserved in Escherichia coli K-12); transporter 512719 914583 ECs0481 Escherichia coli O157:H7 str. Sakai transporter NP_308508.2 511355 R 386585 CDS NP_308509.1 15829736 914584 complement(512868..513758) 1 NC_002695.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 513758 914584 ECs0482 Escherichia coli O157:H7 str. Sakai protoheme IX farnesyltransferase NP_308509.1 512868 R 386585 CDS NP_308510.1 15829737 914585 complement(513770..514099) 1 NC_002695.1 similar to CYOD_ECOLI gi|1786632 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit IV 514099 914585 ECs0483 Escherichia coli O157:H7 str. Sakai cytochrome o ubiquinol oxidase subunit IV NP_308510.1 513770 R 386585 CDS NP_308511.1 15829738 914586 complement(514099..514713) 1 NC_002695.1 similar to CYOC_ECOLI gi|1786633 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit III 514713 914586 ECs0484 Escherichia coli O157:H7 str. Sakai cytochrome o ubiquinol oxidase subunit III NP_308511.1 514099 R 386585 CDS NP_308512.1 15829739 914587 complement(514703..516694) 1 NC_002695.1 similar to CYOB_ECOLI gi|1786634 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit I 516694 914587 ECs0485 Escherichia coli O157:H7 str. Sakai cytochrome o ubiquinol oxidase subunit I NP_308512.1 514703 R 386585 CDS NP_308513.1 15829740 914588 complement(516716..517663) 1 NC_002695.1 similar to CYOA_ECOLI gi|1786635 (conserved in Escherichia coli K-12); cytochrome o ubiquinol oxidase subunit II 517663 914588 ECs0486 Escherichia coli O157:H7 str. Sakai cytochrome o ubiquinol oxidase subunit II NP_308513.1 516716 R 386585 CDS NP_308514.1 15829741 914589 complement(518123..519598) 1 NC_002695.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 519598 ampG 914589 ampG Escherichia coli O157:H7 str. Sakai muropeptide transporter NP_308514.1 518123 R 386585 CDS NP_308515.2 38703867 914590 complement(519642..520220) 1 NC_002695.1 similar to YAJG_ECOLI gi|1786637 (conserved in Escherichia coli K-12); hypothetical protein 520220 914590 ECs0488 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308515.2 519642 R 386585 CDS NP_308516.2 38703868 914591 520525..520842 1 NC_002695.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 520842 914591 ECs0489 Escherichia coli O157:H7 str. Sakai transcriptional regulator BolA NP_308516.2 520525 D 386585 CDS NP_308517.1 15829744 914592 521186..522484 1 NC_002695.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 522484 tig 914592 tig Escherichia coli O157:H7 str. Sakai trigger factor NP_308517.1 521186 D 386585 CDS NP_308518.1 15829745 914593 522729..523352 1 NC_002695.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 523352 clpP 914593 clpP Escherichia coli O157:H7 str. Sakai ATP-dependent Clp protease proteolytic subunit NP_308518.1 522729 D 386585 CDS NP_308519.1 15829746 914594 523478..524752 1 NC_002695.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding protein ClpX 524752 clpX 914594 clpX Escherichia coli O157:H7 str. Sakai ATP-dependent protease ATP-binding protein ClpX NP_308519.1 523478 D 386585 CDS NP_308520.1 15829747 914595 524940..527294 1 NC_002695.1 similar to LON_ECOLI gi|1786643 (conserved in Escherichia coli K-12); DNA-binding ATP-dependent protease La 527294 914595 ECs0493 Escherichia coli O157:H7 str. Sakai DNA-binding ATP-dependent protease La NP_308520.1 524940 D 386585 CDS NP_308521.1 15829748 914596 527503..527775 1 NC_002695.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 527775 914596 ECs0494 Escherichia coli O157:H7 str. Sakai transcriptional regulator HU subunit beta NP_308521.1 527503 D 386585 CDS NP_308522.1 15829749 914597 527967..529838 1 NC_002695.1 similar to YBAU_ECOLI gi|1786645 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase 529838 914597 ECs0495 Escherichia coli O157:H7 str. Sakai peptidyl-prolyl cis-trans isomerase NP_308522.1 527967 D 386585 CDS NP_308523.1 15829750 914598 529989..530360 1 NC_002695.1 similar to YBAV_ECOLI gi|1786646 (conserved in Escherichia coli K-12); hypothetical protein 530360 914598 ECs0496 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308523.1 529989 D 386585 CDS NP_308524.1 15829751 914599 530466..530864 1 NC_002695.1 similar to YBAW_ECOLI gi|1786647 (conserved in Escherichia coli K-12); hypothetical protein 530864 914599 ECs0497 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308524.1 530466 D 386585 CDS NP_308525.1 15829752 914600 complement(530916..531611) 1 NC_002695.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 531611 914600 ECs0498 Escherichia coli O157:H7 str. Sakai queuosine biosynthesis protein QueC NP_308525.1 530916 R 386585 CDS NP_308526.1 15829753 914601 complement(531676..533376) 1 NC_002695.1 similar to YBAE_ECOLI gi|1786650 (conserved in Escherichia coli K-12); hypothetical protein 533376 914601 ECs0499 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308526.1 531676 R 386585 CDS NP_308527.1 15829754 914602 533464..534294 1 NC_002695.1 similar to COF_ECOLI gi|1786651 (conserved in Escherichia coli K-12); hypothetical protein 534294 914602 ECs0500 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308527.1 533464 D 386585 CDS NP_308528.2 38703869 914603 534446..534904 1 NC_002695.1 similar to YBAO_ECOLI gi|1786652 (conserved in Escherichia coli K-12); LRP-like transcriptional regulator 534904 914603 ECs0501 Escherichia coli O157:H7 str. Sakai LRP-like transcriptional regulator NP_308528.2 534446 D 386585 CDS NP_308529.1 15829756 914604 534934..536706 1 NC_002695.1 similar to MDLA_ECOLI gi|1786653 (conserved in Escherichia coli K-12); multidrug transporter membrane\ATP-binding components 536706 914604 ECs0502 Escherichia coli O157:H7 str. Sakai multidrug transporter membrane\ATP-binding components NP_308529.1 534934 D 386585 CDS NP_308530.1 15829757 914605 536699..538480 1 NC_002695.1 similar to MDLB_ECOLI gi|1786654 (conserved in Escherichia coli K-12); multidrug transporter membrane\ATP-binding components 538480 914605 ECs0503 Escherichia coli O157:H7 str. Sakai multidrug transporter membrane\ATP-binding components NP_308530.1 536699 D 386585 CDS NP_308531.1 15829758 914607 538661..538999 1 NC_002695.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 538999 914607 ECs0504 Escherichia coli O157:H7 str. Sakai nitrogen regulatory protein P-II 2 NP_308531.1 538661 D 386585 CDS NP_308532.1 15829759 914608 539029..540315 1 NC_002695.1 similar to AMTB_ECOLI gi|1786656 (conserved in Escherichia coli K-12); ammonium transporter 540315 914608 ECs0505 Escherichia coli O157:H7 str. Sakai ammonium transporter NP_308532.1 539029 D 386585 CDS NP_308533.1 15829760 914609 complement(540364..541224) 1 NC_002695.1 similar to TESB_ECOLI gi|1786657 (conserved in Escherichia coli K-12); acyl-CoA thioesterase 541224 914609 ECs0506 Escherichia coli O157:H7 str. Sakai acyl-CoA thioesterase NP_308533.1 540364 R 386585 CDS NP_308534.2 38703870 914610 541457..542014 1 NC_002695.1 similar to YBAY_ECOLI gi|1786658 (conserved in Escherichia coli K-12); glycoprotein/polysaccharide metabolism 542014 914610 ECs0507 Escherichia coli O157:H7 str. Sakai glycoprotein/polysaccharide metabolism NP_308534.2 541457 D 386585 CDS NP_308535.1 15829762 914611 complement(542047..542436) 1 NC_002695.1 similar to YBAZ_ECOLI gi|1786659 (conserved in Escherichia coli K-12); hypothetical protein 542436 914611 ECs0508 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308535.1 542047 R 386585 CDS NP_308536.1 15829763 914613 542737..543090 1 NC_002695.1 similar to YBAA_ECOLI gi|1786661 (conserved in Escherichia coli K-12); hypothetical protein 543090 914613 ECs0509 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308536.1 542737 D 386585 CDS NP_308537.1 15829764 914614 complement(543132..544688) 1 NC_002695.1 similar to YLAB_ECOLI gi|1786662 (conserved in Escherichia coli K-12); hypothetical protein 544688 914614 ECs0510 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308537.1 543132 R 386585 CDS NP_308538.2 38703871 914615 complement(544846..545316) 1 NC_002695.1 similar to YLAC_ECOLI gi|1786663 (conserved in Escherichia coli K-12); hypothetical protein 545316 914615 ECs0511 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308538.2 544846 R 386585 CDS NP_308539.1 15829766 914616 complement(545432..545983) 1 NC_002695.1 similar to YLAD_ECOLI gi|1786664 (conserved in Escherichia coli K-12); maltose O-acetyltransferase 545983 914616 ECs0512 Escherichia coli O157:H7 str. Sakai maltose O-acetyltransferase NP_308539.1 545432 R 386585 CDS NP_308540.1 15829767 914617 complement(546155..546373) 1 NC_002695.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 546373 914617 ECs0513 Escherichia coli O157:H7 str. Sakai hemolysin expression-modulating protein NP_308540.1 546155 R 386585 CDS NP_308541.1 15829768 914618 complement(546399..546773) 1 NC_002695.1 similar to YBAJ_ECOLI gi|1786666 (conserved in Escherichia coli K-12); hypothetical protein 546773 914618 ECs0514 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308541.1 546399 R 386585 CDS NP_308542.1 15829769 914619 complement(547319..550468) 1 NC_002695.1 similar to ACRB_ECOLI gi|1786667 (conserved in Escherichia coli K-12); acridine efflux pump 550468 914619 ECs0515 Escherichia coli O157:H7 str. Sakai acridine efflux pump NP_308542.1 547319 R 386585 CDS NP_308543.1 15829770 914620 complement(550491..551684) 1 NC_002695.1 similar to ACRA_ECOLI gi|1786668 (conserved in Escherichia coli K-12); acridine efflux pump 551684 914620 ECs0516 Escherichia coli O157:H7 str. Sakai acridine efflux pump NP_308543.1 550491 R 386585 CDS NP_308544.1 15829771 914621 551826..552473 1 NC_002695.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; AcrR family transcriptional regulator 552473 914621 ECs0517 Escherichia coli O157:H7 str. Sakai AcrR family transcriptional regulator NP_308544.1 551826 D 386585 CDS NP_308545.1 15829772 914622 552601..555963 1 NC_002695.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 555963 914622 ECs0518 Escherichia coli O157:H7 str. Sakai potassium efflux protein KefA NP_308545.1 552601 D 386585 CDS NP_308546.1 15829773 914623 complement(556002..556166) 1 NC_002695.1 similar to YBAM_ECOLI GI:1786672 (conserved in Escherichia coli K-12); hypothetical protein 556166 914623 ECs0519 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308546.1 556002 R 386585 CDS NP_308547.1 15829774 914624 complement(556180..556707) 1 NC_002695.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 556707 914624 ECs0520 Escherichia coli O157:H7 str. Sakai primosomal replication protein N'' NP_308547.1 556180 R 386585 CDS NP_308548.1 15829775 914625 556777..557154 1 NC_002695.1 gene 58; similar to YBAN_ECOLI gi|1786674 (conserved in Escherichia coli K-12); hypothetical protein 557154 914625 ECs0521 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308548.1 556777 D 386585 CDS NP_308549.1 15829776 914626 557307..557858 1 NC_002695.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 557858 914626 ECs0522 Escherichia coli O157:H7 str. Sakai adenine phosphoribosyltransferase NP_308549.1 557307 D 386585 CDS NP_308550.1 15829777 914627 557987..559918 1 NC_002695.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 559918 914627 ECs0523 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunits gamma and tau NP_308550.1 557987 D 386585 CDS NP_308551.1 15829778 914628 559971..560300 1 NC_002695.1 similar to YBAB_ECOLI gi|1786677 (conserved in Escherichia coli K-12); hypothetical protein 560300 914628 ECs0524 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308551.1 559971 D 386585 CDS NP_308552.1 15829779 914629 560300..560905 1 NC_002695.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 560905 recR 914629 recR Escherichia coli O157:H7 str. Sakai recombination protein RecR NP_308552.1 560300 D 386585 CDS NP_308553.1 15829780 914630 561015..562889 1 NC_002695.1 molecular chaperone; heat shock protein 90 562889 914630 ECs0526 Escherichia coli O157:H7 str. Sakai heat shock protein 90 NP_308553.1 561015 D 386585 CDS NP_308554.1 15829781 914631 563070..563714 1 NC_002695.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 563714 adk 914631 adk Escherichia coli O157:H7 str. Sakai adenylate kinase NP_308554.1 563070 D 386585 CDS NP_308555.1 15829782 914632 563846..564808 1 NC_002695.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 564808 hemH 914632 hemH Escherichia coli O157:H7 str. Sakai ferrochelatase NP_308555.1 563846 D 386585 CDS NP_308556.1 15829783 914633 complement(564805..565764) 1 NC_002695.1 similar to YBAC_ECOLI gi|1786682 (conserved in Escherichia coli K-12); acetyl esterase 565764 914633 ECs0529 Escherichia coli O157:H7 str. Sakai acetyl esterase NP_308556.1 564805 R 386585 CDS NP_308557.1 15829784 914634 565916..567220 1 NC_002695.1 similar to GSK_ECOLI gi|1786684 (conserved in Escherichia coli K-12); inosine-guanosine kinase 567220 914634 ECs0530 Escherichia coli O157:H7 str. Sakai inosine-guanosine kinase NP_308557.1 565916 D 386585 CDS NP_308558.1 15829785 914635 complement(567353..569029) 1 NC_002695.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 569029 914635 ECs0531 Escherichia coli O157:H7 str. Sakai cation:proton antiport protein NP_308558.1 567353 R 386585 CDS NP_308559.1 15829786 914636 complement(569266..570486) 1 NC_002695.1 similar to FSR_ECOLI gi|1786686 (conserved in Escherichia coli K-12); fosmidomycin resistance protein 570486 914636 ECs0532 Escherichia coli O157:H7 str. Sakai fosmidomycin resistance protein NP_308559.1 569266 R 386585 CDS NP_308560.1 15829787 914637 570704..572356 1 NC_002695.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 572356 ushA 914637 ushA Escherichia coli O157:H7 str. Sakai bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic NP_308560.1 570704 D 386585 CDS NP_308561.1 15829788 914638 complement(572393..572872) 1 NC_002695.1 similar to YBAK_ECOLI gi|1786688 (conserved in Escherichia coli K-12); hypothetical protein 572872 914638 ECs0534 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308561.1 572393 R 386585 CDS NP_308562.1 15829789 914639 complement(573076..573870) 1 NC_002695.1 similar to YBAP_ECOLI gi|1786689 (conserved in Escherichia coli K-12); ligase 573870 914639 ECs0535 Escherichia coli O157:H7 str. Sakai ligase NP_308562.1 573076 R 386585 CDS NP_308563.1 15829790 914640 573954..574349 1 NC_002695.1 similar to YBAQ_ECOLI gi|1786690 (conserved in Escherichia coli K-12); hypothetical protein 574349 914640 ECs0536 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308563.1 573954 D 386585 CDS NP_308564.1 15829791 914641 complement(574564..577068) 1 NC_002695.1 similar to COPA_ECOLI gi|2493016 (conserved in Escherichia coli K-12); copper exporting ATPase 577068 copA 914641 copA Escherichia coli O157:H7 str. Sakai copper exporting ATPase NP_308564.1 574564 R 386585 CDS NP_308565.1 15829792 914642 577330..578262 1 NC_002695.1 catalyzes the formation of glutamate from glutamine; glutaminase 578262 914642 ECs0538 Escherichia coli O157:H7 str. Sakai glutaminase NP_308565.1 577330 D 386585 CDS NP_308566.1 15829793 914643 578265..579557 1 NC_002695.1 similar to YBAT_ECOLI gi|1786694 (conserved in Escherichia coli K-12); amino acid/amine transport protein 579557 914643 ECs0539 Escherichia coli O157:H7 str. Sakai amino acid/amine transport protein NP_308566.1 578265 D 386585 CDS NP_308567.1 15829794 914644 579895..581250 1 NC_002695.1 similar to outer membrane transport proteins e.g. CyaE protein [Bordetella pertussis] gi|117799|sp|P11092|CYAE_BORPE; outer membrane transport protein 581250 914644 ECs0540 Escherichia coli O157:H7 str. Sakai outer membrane transport protein NP_308567.1 579895 D 386585 CDS NP_308568.1 15829795 914888 581353..585738 1 NC_002695.1 similar to hypothetical protein [Synechocystis sp. strain PCC 6803] gi|7469433|pir||S76109; similar toRTX protein [Aeromonas salmonicida] gi|6752871|gb|AAF27914.1|AF218037_1; hypothetical protein 585738 914888 ECs0541 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308568.1 581353 D 386585 CDS NP_308569.1 15829796 914929 585946..601821 1 NC_002695.1 similar to hypothetical protein [Synechocystis sp. strain PCC 6803] gi|7469433|pir||S76109; , similar to RTX protein [Aeromonas salmonicida] gi|6752871|gb|AAF27914.1|AF218037_1; hypothetical protein 601821 914929 ECs0542 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308569.1 585946 D 386585 CDS NP_308570.1 15829797 915052 601867..603987 1 NC_002695.1 similar to transporters (ATP-binding proteins) e.g. LktB [Actinobacillus actinomycetemcomitans] gi|126357|sp|P23702|HLYB_ACTAC; ABC transporter ATP-binding protein 603987 915052 ECs0543 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308570.1 601867 D 386585 CDS NP_308571.1 15829798 915176 603984..605159 1 NC_002695.1 similar to membrane fusion proteins e.g. [Sinorhizobium meliloti] gi|4689001|emb|CAB41456.1|; membrane fusion protein of a transport system 605159 915176 ECs0544 Escherichia coli O157:H7 str. Sakai membrane fusion protein of a transport system NP_308571.1 603984 D 386585 CDS NP_308572.1 15829799 915192 605156..605563 1 NC_002695.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 605563 915192 ECs0545 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator CueR NP_308572.1 605156 D 386585 CDS NP_308573.1 15829800 915251 complement(605767..606189) 1 NC_002695.1 lipoprotein 606189 915251 ECs0546 Escherichia coli O157:H7 str. Sakai lipoprotein NP_308573.1 605767 R 386585 CDS NP_308575.1 15829802 915314 complement(606274..607290) 1 NC_002695.1 similar to adhesin/invasin [Neisseria meningitidis MC58] gi|7227256|gb|AAF42321.1|, surface protein [Xylella fastidiosa] gi|9106565|gb|AAF84338.1|AE003982_11; adhesin 607290 915314 ECs0548 Escherichia coli O157:H7 str. Sakai adhesin NP_308575.1 606274 R 386585 CDS NP_308576.1 15829803 915335 607657..608019 1 NC_002695.1 hypothetical protein 608019 915335 ECs0549 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308576.1 607657 D 386585 CDS NP_308578.1 15829805 915339 complement(608198..608653) 1 NC_002695.1 similar to YBBJ_ECOLI gi|1786696 (conserved in Escherichia coli K-12); hypothetical protein 608653 915339 ECs0551 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308578.1 608198 R 386585 CDS NP_308579.1 15829806 915340 complement(608653..609570) 1 NC_002695.1 similar to YBBK_ECOLI gi|1786697 (conserved in Escherichia coli K-12); protease 609570 915340 ECs0552 Escherichia coli O157:H7 str. Sakai protease NP_308579.1 608653 R 386585 CDS NP_308580.1 15829807 915342 609716..610393 1 NC_002695.1 similar to YBBL_ECOLI gi|1786698 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 610393 915342 ECs0553 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308580.1 609716 D 386585 CDS NP_308581.2 38703872 915343 610380..611159 1 NC_002695.1 similar to YBBM_ECOLI gi|1786699 (conserved in Escherichia coli K-12); metal resistance protein 611159 915343 ECs0554 Escherichia coli O157:H7 str. Sakai metal resistance protein NP_308581.2 610380 D 386585 CDS NP_308582.2 38703873 915346 complement(611222..612076) 1 NC_002695.1 similar to YBBN_ECOLI gi|1786700 (conserved in Escherichia coli K-12); thioredoxin-like protein 612076 915346 ECs0555 Escherichia coli O157:H7 str. Sakai thioredoxin-like protein NP_308582.2 611222 R 386585 CDS NP_308583.1 15829810 915348 complement(612137..612946) 1 NC_002695.1 similar to YBBO_ECOLI gi|1786701 (conserved in Escherichia coli K-12); short chain dehydrogenase 612946 915348 ECs0556 Escherichia coli O157:H7 str. Sakai short chain dehydrogenase NP_308583.1 612137 R 386585 CDS NP_308584.1 15829811 915350 complement(612936..613562) 1 NC_002695.1 similar to TESA_ECOLI gi|1786702 (conserved in Escherichia coli K-12); multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 613562 915350 ECs0558 Escherichia coli O157:H7 str. Sakai multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 NP_308584.1 612936 R 386585 CDS NP_308585.1 15829812 915351 613530..614216 1 NC_002695.1 similar to YBBA_ECOLI gi|1786703 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 614216 915351 ECs0557 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308585.1 613530 D 386585 CDS NP_308586.1 15829813 915353 614213..616627 1 NC_002695.1 similar to YBBP_ECOLI gi|1786704 (conserved in Escherichia coli K-12); oxidoreductase 616627 915353 ECs0559 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_308586.1 614213 D 386585 CDS NP_308587.1 15829814 915354 617057..621253 1 NC_002695.1 core protein with extension; similar to RHSD_ECOLI gi|1786706; similar to B0499_ECOLI gi|1786708; Rhs protein; protein RhsD 621253 915354 ECs0560 Escherichia coli O157:H7 str. Sakai protein RhsD NP_308587.1 617057 D 386585 CDS NP_308588.1 15829815 915355 621234..621494 1 NC_002695.1 similar to YBBD_ECOLI gi|1786709 (conserved in Escherichia coli K-12); hypothetical protein 621494 915355 ECs0561 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308588.1 621234 D 386585 CDS NP_308590.2 38703874 915360 complement(622238..622609) 1 NC_002695.1 similar to B0502_ECOLI gi|1786711 (conserved in Escherichia coli K-12); hypothetical protein 622609 915360 ECs0563 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308590.2 622238 R 386585 CDS NP_308591.1 15829818 915481 complement(622725..623819) 1 NC_002695.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 623819 915481 ECs0564 Escherichia coli O157:H7 str. Sakai tRNA 2-selenouridine synthase NP_308591.1 622725 R 386585 CDS NP_308592.1 15829819 915486 complement(623888..624814) 1 NC_002695.1 activator of the allDC-ylbA operon involved in allantoin utilization; AllS family transcriptional regulator 624814 915486 ECs0565 Escherichia coli O157:H7 str. Sakai AllS family transcriptional regulator NP_308592.1 623888 R 386585 CDS NP_308593.1 15829820 915530 625044..625526 1 NC_002695.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 625526 915530 ECs0566 Escherichia coli O157:H7 str. Sakai ureidoglycolate hydrolase NP_308593.1 625044 D 386585 CDS NP_308594.1 15829821 915706 625604..626419 1 NC_002695.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 626419 915706 ECs0567 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor AllR NP_308594.1 625604 D 386585 CDS NP_308595.1 15829822 915770 626509..628290 1 NC_002695.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 628290 915770 ECs0568 Escherichia coli O157:H7 str. Sakai glyoxylate carboligase NP_308595.1 626509 D 386585 CDS NP_308596.1 15829823 915783 628303..629079 1 NC_002695.1 similar to HYI_ECOLI gi|232160 (conserved in Escherichia coli K-12); hydroxypyruvate isomerase 629079 915783 ECs0569 Escherichia coli O157:H7 str. Sakai hydroxypyruvate isomerase NP_308596.1 628303 D 386585 CDS NP_308597.1 15829824 915794 629180..630058 1 NC_002695.1 similar to GLXR_ECOLI gi|2494062 (conserved in Escherichia coli K-12); tartronic semialdehyde reductase 630058 915794 ECs0570 Escherichia coli O157:H7 str. Sakai tartronic semialdehyde reductase NP_308597.1 629180 D 386585 CDS NP_308598.1 15829825 915825 630090..630368 1 NC_002695.1 similar to YBBV_ECOLI gi|1786720 (conserved in Escherichia coli K-12); hypothetical protein 630368 915825 ECs0571 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308598.1 630090 D 386585 CDS NP_308599.1 15829826 915888 630227..631618 1 NC_002695.1 similar to YBBW_ECOLI gi|1786721 (conserved in Escherichia coli K-12); allantoin permease 631618 915888 ECs0572 Escherichia coli O157:H7 str. Sakai allantoin permease NP_308599.1 630227 D 386585 CDS NP_308602.2 38703875 916089 633073..634374 1 NC_002695.1 similar to YBBY_ECOLI gi|1786723 (conserved in Escherichia coli K-12); purine permease YbbY 634374 916089 ECs0575 Escherichia coli O157:H7 str. Sakai purine permease YbbY NP_308602.2 633073 D 386585 CDS NP_308603.1 15829830 916187 634396..635541 1 NC_002695.1 similar to GLXK_ECOLI gi|2495546 (conserved in Escherichia coli K-12); glycerate kinase 635541 916187 ECs0576 Escherichia coli O157:H7 str. Sakai glycerate kinase NP_308603.1 634396 D 386585 CDS NP_308604.1 15829831 916390 complement(635769..636554) 1 NC_002695.1 similar to YLBA_ECOLI gi|1786725 (conserved in Escherichia coli K-12); hypothetical protein 636554 916390 ECs0577 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308604.1 635769 R 386585 CDS NP_308605.1 15829832 916571 complement(636565..637800) 1 NC_002695.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 637800 916571 ECs0578 Escherichia coli O157:H7 str. Sakai allantoate amidohydrolase NP_308605.1 636565 R 386585 CDS NP_308606.1 15829833 916572 complement(637822..638871) 1 NC_002695.1 similar to ALLD_ECOLI gi|2497861 (conserved in Escherichia coli K-12); ureidoglycolate dehydrogenase 638871 916572 ECs0579 Escherichia coli O157:H7 str. Sakai ureidoglycolate dehydrogenase NP_308606.1 637822 R 386585 CDS NP_308607.1 15829834 916573 639188..640855 1 NC_002695.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 640855 916573 ECs0580 Escherichia coli O157:H7 str. Sakai membrane protein FdrA NP_308607.1 639188 D 386585 CDS NP_308608.1 15829835 916600 641123..642124 1 NC_002695.1 similar to YLBE_ECOLI gi|1786730 (conserved in Escherichia coli K-12); hypothetical protein 642124 916600 ECs0581 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308608.1 641123 D 386585 CDS NP_308609.1 15829836 916659 642135..642950 1 NC_002695.1 similar to YLBF_ECOLI gi|1786731 (conserved in Escherichia coli K-12); carboxylase 642950 916659 ECs0582 Escherichia coli O157:H7 str. Sakai carboxylase NP_308609.1 642135 D 386585 CDS NP_308610.1 15829837 916781 642947..643840 1 NC_002695.1 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 643840 916781 ECs0583 Escherichia coli O157:H7 str. Sakai carbamate kinase NP_308610.1 642947 D 386585 CDS NP_308611.1 15829838 916809 complement(643979..645046) 1 NC_002695.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 645046 916809 ECs0584 Escherichia coli O157:H7 str. Sakai phosphoribosylaminoimidazole carboxylase ATPase subunit NP_308611.1 643979 R 386585 CDS NP_308612.1 15829839 916940 complement(645043..645552) 1 NC_002695.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 645552 916940 ECs0585 Escherichia coli O157:H7 str. Sakai phosphoribosylaminoimidazole carboxylase catalytic subunit NP_308612.1 645043 R 386585 CDS NP_308613.1 15829840 916941 complement(645670..646392) 1 NC_002695.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 646392 916941 ECs0586 Escherichia coli O157:H7 str. Sakai UDP-2,3-diacylglucosamine hydrolase NP_308613.1 645670 R 386585 CDS NP_308614.1 15829841 916942 complement(646395..646889) 1 NC_002695.1 similar to PPIB_ECOLI gi|1786736 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase B 646889 916942 ECs0587 Escherichia coli O157:H7 str. Sakai peptidyl-prolyl cis-trans isomerase B NP_308614.1 646395 R 386585 CDS NP_308615.1 15829842 916943 647063..648448 1 NC_002695.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 648448 cysS 916943 cysS Escherichia coli O157:H7 str. Sakai cysteinyl-tRNA synthetase NP_308615.1 647063 D 386585 CDS NP_308616.1 15829843 916944 complement(648484..649005) 1 NC_002695.1 similar to YBCI_ECOLI gi|1786738 (conserved in Escherichia coli K-12); hypothetical protein 649005 916944 ECs0589 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308616.1 648484 R 386585 CDS NP_308617.2 38703876 916945 complement(649113..649325) 1 NC_002695.1 similar to YBCJ_ECOLI gi|1786740 (conserved in Escherichia coli K-12); hypothetical protein 649325 916945 ECs0590 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308617.2 649113 R 386585 CDS NP_308618.1 15829845 916946 complement(649327..650193) 1 NC_002695.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 650193 916946 ECs0591 Escherichia coli O157:H7 str. Sakai bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_308618.1 649327 R 386585 CDS NP_308619.2 38703877 916947 650664..651206 1 NC_002695.1 similar to SFMA_ECOLI gi|1786742 (conserved in Escherichia coli K-12); fimbrial-like protein 651206 916947 ECs0592 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_308619.2 650664 D 386585 CDS NP_308620.1 15829847 916948 651426..652118 1 NC_002695.1 similar to SFMC_ECOLI gi|1786743 (conserved in Escherichia coli K-12); chaperone 652118 916948 ECs0593 Escherichia coli O157:H7 str. Sakai chaperone NP_308620.1 651426 D 386585 CDS NP_308621.1 15829848 916950 652149..654758 1 NC_002695.1 similar to SFMD_ECOLI gi|1786744 (conserved in Escherichia coli K-12); outer membrane protein 654758 916950 ECs0594 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_308621.1 652149 D 386585 CDS NP_308622.1 15829849 916951 654801..655778 1 NC_002695.1 similar to SFMH_ECOLI gi|1786745 (conserved in Escherichia coli K-12); protein SfmH 655778 916951 ECs0595 Escherichia coli O157:H7 str. Sakai protein SfmH NP_308622.1 654801 D 386585 CDS NP_308623.1 15829850 916953 655789..656304 1 NC_002695.1 similar to SFMF_ECOLI gi|1786746 (conserved in Escherichia coli K-12); fimbrial protein 656304 916953 ECs0596 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_308623.1 655789 D 386585 CDS NP_308624.1 15829851 916954 complement(656307..656939) 1 NC_002695.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 656939 916954 ECs0597 Escherichia coli O157:H7 str. Sakai transcriptional regulator FimZ NP_308624.1 656307 R 386585 CDS NP_308625.1 15829852 916956 complement(657304..658065) 1 NC_002695.1 similar to ENVY_ECOLI gi|1786778 (conserved in Escherichia coli K-12); envelope protein; EnvY 658065 916956 ECs0598 Escherichia coli O157:H7 str. Sakai EnvY NP_308625.1 657304 R 386585 CDS NP_308626.1 15829853 916957 complement(658248..659138) 1 NC_002695.1 similar to YBCH_ECOLI gi|1786779 (conserved in Escherichia coli K-12); hypothetical protein 659138 916957 ECs0599 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308626.1 658248 R 386585 CDS NP_308627.1 15829854 916958 complement(659139..662111) 1 NC_002695.1 similar to NFRA_ECOLI gi|1786780 (conserved in Escherichia coli K-12); bacteriophage N4 receptor, outer membrane subunit 662111 916958 ECs0600 Escherichia coli O157:H7 str. Sakai bacteriophage N4 receptor, outer membrane subunit NP_308627.1 659139 R 386585 CDS NP_308628.1 15829855 916959 complement(662098..664335) 1 NC_002695.1 similar to NFRB_ECOLI gi|1786781 (conserved in Escherichia coli K-12); bacteriophage N4 adsorption protein B 664335 nfrB 916959 nfrB Escherichia coli O157:H7 str. Sakai bacteriophage N4 adsorption protein B NP_308628.1 662098 R 386585 CDS NP_308629.1 15829856 916960 complement(664601..665737) 1 NC_002695.1 similar to H repeat-associated protein in RhsB element [Escherichia coli] gi|140772|sp|P28912|YHHI_ECOLI; H repeat-containing protein 665737 916960 ECs0602 Escherichia coli O157:H7 str. Sakai H repeat-containing protein NP_308629.1 664601 R 386585 CDS NP_944506.1 38703878 2693790 complement(665952..666173) 1 NC_002695.1 hypothetical protein 666173 2693790 ECs5380 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944506.1 665952 R 386585 CDS NP_308630.1 15829857 916961 complement(666200..667534) 1 NC_002695.1 Rhs protein; similar to Rhs protein - Streptomyces coelicolor A3(2) gi|7321289|emb|CAB82067.1; similar toRhsE protein - E. coli gi|2507113|sp|P24211|; Rhs core protein 667534 916961 ECs0603 Escherichia coli O157:H7 str. Sakai Rhs core protein NP_308630.1 666200 R 386585 CDS NP_308631.1 15829858 916962 complement(667703..668110) 1 NC_002695.1 hypothetical protein 668110 916962 ECs0604 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308631.1 667703 R 386585 CDS NP_308632.1 15829859 916963 complement(668128..672978) 1 NC_002695.1 Rhs protein; similar to Rhs protein [Streptomyces coelicolor A3(2)] gi|7321289|emb|CAB82067.1; similar toRhsH protein [Escherichia coli strain ec45] gi|2920634|gb|AAC32471.1; Rhs core protein with extension 672978 916963 ECs0605 Escherichia coli O157:H7 str. Sakai Rhs core protein with extension NP_308632.1 668128 R 386585 CDS NP_308633.1 15829860 916964 complement(672998..673459) 1 NC_002695.1 hypothetical protein 673459 916964 ECs0606 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308633.1 672998 R 386585 CDS NP_308634.1 15829861 916965 complement(673487..675388) 1 NC_002695.1 similar to Vgr proteins e.g. [Escherichia coli strain ec11] gi|2920640|gb|AAC32475.1; hypothetical protein 675388 916965 ECs0607 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308634.1 673487 R 386585 CDS NP_308635.1 15829862 916966 complement(675982..677430) 1 NC_002695.1 similar to YBCZ_ECOLI gi|1786783 (conserved in Escherichia coli K-12); sensor kinase CusS 677430 916966 ECs0608 Escherichia coli O157:H7 str. Sakai sensor kinase CusS NP_308635.1 675982 R 386585 CDS NP_308636.1 15829863 916967 complement(677420..678103) 1 NC_002695.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; CusR family transcriptional regulator 678103 916967 ECs0609 Escherichia coli O157:H7 str. Sakai CusR family transcriptional regulator NP_308636.1 677420 R 386585 CDS NP_308637.1 15829864 916968 678260..679642 1 NC_002695.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 679642 916968 ECs0610 Escherichia coli O157:H7 str. Sakai copper/silver efflux system outer membrane protein CusC NP_308637.1 678260 D 386585 CDS NP_308638.1 15829865 916969 679666..679998 1 NC_002695.1 similar to YLCC_ECOLI gi|1786786 (conserved in Escherichia coli K-12); copper-binding protein 679998 916969 ECs0611 Escherichia coli O157:H7 str. Sakai copper-binding protein NP_308638.1 679666 D 386585 CDS NP_308639.1 15829866 916970 680014..681237 1 NC_002695.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 681237 916970 ECs0612 Escherichia coli O157:H7 str. Sakai copper/silver efflux system membrane fusion protein CusB NP_308639.1 680014 D 386585 CDS NP_308640.1 15829867 916972 681249..684386 1 NC_002695.1 similar to YBDE_ECOLI gi|1786788 (conserved in Escherichia coli K-12); inner membrane component for iron transport 684386 916972 ECs0613 Escherichia coli O157:H7 str. Sakai inner membrane component for iron transport NP_308640.1 681249 D 386585 CDS NP_308641.1 15829868 916973 684488..685864 1 NC_002695.1 similar to PHEP_ECOLI gi|1786789 (conserved in Escherichia coli K-12); phenylalanine transporter 685864 916973 ECs0614 Escherichia coli O157:H7 str. Sakai phenylalanine transporter NP_308641.1 684488 D 386585 CDS NP_308642.1 15829869 916974 complement(685932..687179) 1 NC_002695.1 similar to YBDG_ECOLI gi|1786791 (conserved in Escherichia coli K-12); transport 687179 916974 ECs0615 Escherichia coli O157:H7 str. Sakai transport NP_308642.1 685932 R 386585 CDS NP_308643.1 15829870 916975 complement(687287..687940) 1 NC_002695.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 687940 916975 ECs0616 Escherichia coli O157:H7 str. Sakai dihydropteridine reductase NP_308643.1 687287 R 386585 CDS NP_308644.1 15829871 916976 complement(688034..688402) 1 NC_002695.1 similar to YBDF_ECOLI gi|1786793 (conserved in Escherichia coli K-12); hypothetical protein 688402 916976 ECs0617 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308644.1 688034 R 386585 CDS NP_308645.1 15829872 916977 complement(688467..688715) 1 NC_002695.1 similar to YBDJ_ECOLI gi|1786794 (conserved in Escherichia coli K-12); hypothetical protein 688715 916977 ECs0618 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308645.1 688467 R 386585 CDS NP_308646.1 15829873 916978 complement(688781..689899) 1 NC_002695.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 689899 916978 ECs0619 Escherichia coli O157:H7 str. Sakai carboxylate-amine ligase NP_308646.1 688781 R 386585 CDS NP_308647.1 15829874 916979 690338..690490 1 NC_002695.1 similar to YBDY_ECOLI gi|3025009|sp|P77091 (conserved in Escherichia coli K-12); hypothetical protein 690490 916979 ECs0620 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308647.1 690338 D 386585 CDS NP_308648.1 15829875 916980 690742..690993 1 NC_002695.1 similar to hypothetical protein in cspA-glyS intergenic region [Escherichia coli] gi|3025009|sp|P77091; hypothetical protein 690993 916980 ECs0621 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308648.1 690742 D 386585 CDS NP_308649.1 15829876 916981 complement(691115..691744) 1 NC_002695.1 similar to ENTD_ECOLI gi|1786797 (conserved in Escherichia coli K-12); phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 691744 916981 ECs0622 Escherichia coli O157:H7 str. Sakai phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex NP_308649.1 691115 R 386585 CDS NP_308650.1 15829877 916982 complement(691910..694150) 1 NC_002695.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 694150 916982 ECs0623 Escherichia coli O157:H7 str. Sakai outer membrane receptor FepA NP_308650.1 691910 R 386585 CDS NP_308651.1 15829878 916983 694471..695595 1 NC_002695.1 similar to FES_ECOLI gi|1786799 (conserved in Escherichia coli K-12); enterobactin/ferric enterobactin esterase 695595 916983 ECs0624 Escherichia coli O157:H7 str. Sakai enterobactin/ferric enterobactin esterase NP_308651.1 694471 D 386585 CDS NP_944507.1 38703879 2693791 695598..695816 1 NC_002695.1 hypothetical protein 695816 2693791 ECs5381 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944507.1 695598 D 386585 CDS NP_308652.1 15829879 916984 695813..699694 1 NC_002695.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 699694 entF 916984 entF Escherichia coli O157:H7 str. Sakai enterobactin synthase subunit F NP_308652.1 695813 D 386585 CDS NP_308653.1 15829880 916985 699910..701043 1 NC_002695.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 701043 916985 ECs0626 Escherichia coli O157:H7 str. Sakai ferric enterobactin transport protein FepE NP_308653.1 699910 D 386585 CDS NP_308654.1 15829881 916986 complement(701040..701855) 1 NC_002695.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 701855 916986 ECs0627 Escherichia coli O157:H7 str. Sakai iron-enterobactin transporter ATP-binding protein NP_308654.1 701040 R 386585 CDS NP_308655.1 15829882 916987 complement(701852..702844) 1 NC_002695.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 702844 916987 ECs0628 Escherichia coli O157:H7 str. Sakai iron-enterobactin transporter permease NP_308655.1 701852 R 386585 CDS NP_308656.1 15829883 916988 complement(702841..703845) 1 NC_002695.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 703845 916988 ECs0629 Escherichia coli O157:H7 str. Sakai iron-enterobactin transporter membrane protein NP_308656.1 702841 R 386585 CDS NP_308657.1 15829884 916989 703956..705206 1 NC_002695.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 705206 916989 ECs0630 Escherichia coli O157:H7 str. Sakai enterobactin exporter EntS NP_308657.1 703956 D 386585 CDS NP_308658.1 15829885 916990 complement(705210..706166) 1 NC_002695.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 706166 916990 ECs0631 Escherichia coli O157:H7 str. Sakai iron-enterobactin transporter periplasmic binding protein NP_308658.1 705210 R 386585 CDS NP_308659.1 15829886 916991 706355..707530 1 NC_002695.1 synthesizes isochorismate acid from chorismate; isochorismate synthase 707530 916991 ECs0632 Escherichia coli O157:H7 str. Sakai isochorismate synthase NP_308659.1 706355 D 386585 CDS NP_308660.1 15829887 916992 707540..709150 1 NC_002695.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 709150 entE 916992 entE Escherichia coli O157:H7 str. Sakai enterobactin synthase subunit E NP_308660.1 707540 D 386585 CDS NP_308661.1 15829888 916993 709164..710021 1 NC_002695.1 similar to ENTB_ECOLI gi|1786811 (conserved in Escherichia coli K-12); 2,3-dihydro-2,3-dihydroxybenzoate synthetase 710021 916993 ECs0634 Escherichia coli O157:H7 str. Sakai 2,3-dihydro-2,3-dihydroxybenzoate synthetase NP_308661.1 709164 D 386585 CDS NP_308662.1 15829889 916994 710021..710767 1 NC_002695.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 710767 916994 ECs0635 Escherichia coli O157:H7 str. Sakai 2,3-dihydroxybenzoate-2,3-dehydrogenase NP_308662.1 710021 D 386585 CDS NP_308663.1 15829890 916995 710770..711183 1 NC_002695.1 similar to YBDB_ECOLI gi|1786813 (conserved in Escherichia coli K-12); hypothetical protein 711183 916995 ECs0636 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308663.1 710770 D 386585 CDS NP_308664.1 15829891 916996 711364..713469 1 NC_002695.1 similar to CSTA_ECOLI gi|1786814 (conserved in Escherichia coli K-12); carbon starvation protein 713469 916996 ECs0637 Escherichia coli O157:H7 str. Sakai carbon starvation protein NP_308664.1 711364 D 386585 CDS NP_944508.1 38703880 2693792 713651..713848 1 NC_002695.1 hypothetical protein 713848 2693792 ECs5382 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944508.1 713651 D 386585 CDS NP_308665.1 15829892 916997 complement(713858..714946) 1 NC_002695.1 member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein 714946 916997 ECs0638 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308665.1 713858 R 386585 CDS NP_308666.1 15829893 916998 715055..716215 1 NC_002695.1 catalyzes the transfer of an amino moiety; aminotransferase 716215 916998 ECs0639 Escherichia coli O157:H7 str. Sakai aminotransferase NP_308666.1 715055 D 386585 CDS NP_308667.1 15829894 916999 complement(716216..716845) 1 NC_002695.1 similar to YBDM_ECOLI gi|1786817 (conserved in Escherichia coli K-12); hypothetical protein 716845 916999 ECs0640 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308667.1 716216 R 386585 CDS NP_308668.1 15829895 917000 complement(716818..718038) 1 NC_002695.1 similar to YBDN_ECOLI gi|1786818 (conserved in Escherichia coli K-12); hypothetical protein 718038 917000 ECs0641 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308668.1 716818 R 386585 CDS NP_308669.1 15829896 917001 complement(718185..719087) 1 NC_002695.1 similar to YBDO_ECOLI gi|1786820 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 719087 917001 ECs0642 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_308669.1 718185 R 386585 CDS NP_308670.3 162139707 917002 complement(719297..720043) 1 NC_002695.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 720043 dsbG 917002 dsbG Escherichia coli O157:H7 str. Sakai disulfide isomerase/thiol-disulfide oxidase NP_308670.3 719297 R 386585 CDS NP_308671.1 15829898 917003 720415..720978 1 NC_002695.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 720978 917003 ECs0644 Escherichia coli O157:H7 str. Sakai alkyl hydroperoxide reductase NP_308671.1 720415 D 386585 CDS NP_308672.1 15829899 917004 721077..722672 1 NC_002695.1 similar to AHPF_ECOLI gi|1786823 (conserved in Escherichia coli K-12); alkyl hydroperoxide reductase 722672 917004 ECs0645 Escherichia coli O157:H7 str. Sakai alkyl hydroperoxide reductase NP_308672.1 721077 D 386585 CDS NP_308673.1 15829900 917005 complement(722793..723221) 1 NC_002695.1 similar to YBDQ_ECOLI gi|1786824 (conserved in Escherichia coli K-12); hypothetical protein 723221 917005 ECs0646 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308673.1 722793 R 386585 CDS NP_308674.1 15829901 917006 723442..724680 1 NC_002695.1 similar to YBDR_ECOLI gi|1786825 (conserved in Escherichia coli K-12); oxidoreductase 724680 917006 ECs0647 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_308674.1 723442 D 386585 CDS NP_944509.1 38703882 2693760 complement(724684..724872) 1 NC_002695.1 hypothetical protein 724872 2693760 ECs5383 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944509.1 724684 R 386585 CDS NP_308675.1 15829902 917007 724761..725222 1 NC_002695.1 similar to B0609_ECOLI gi|1786826 (conserved in Escherichia coli K-12); hypothetical protein 725222 917007 ECs0648 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308675.1 724761 D 386585 CDS NP_308676.1 15829903 917008 complement(724911..725321) 1 NC_002695.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 725321 917008 ECs0649 Escherichia coli O157:H7 str. Sakai nucleoside diphosphate kinase regulator NP_308676.1 724911 R 386585 CDS NP_308677.1 15829904 917009 complement(725551..726357) 1 NC_002695.1 similar to RNA_ECOLI gi|1786828 (conserved in Escherichia coli K-12); ribonuclease I 726357 917009 ECs0650 Escherichia coli O157:H7 str. Sakai ribonuclease I NP_308677.1 725551 R 386585 CDS NP_308678.1 15829905 917010 complement(726471..727934) 1 NC_002695.1 similar to YBDS_ECOLI gi|1786829 (conserved in Escherichia coli K-12); hypothetical protein 727934 917010 ECs0651 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308678.1 726471 R 386585 CDS NP_308679.1 15829906 917011 complement(727985..728863) 1 NC_002695.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 728863 citG 917011 citG Escherichia coli O157:H7 str. Sakai triphosphoribosyl-dephospho-CoA synthase NP_308679.1 727985 R 386585 CDS NP_308680.1 15829907 917013 complement(728838..729389) 1 NC_002695.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 729389 citX 917013 citX Escherichia coli O157:H7 str. Sakai 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase NP_308680.1 728838 R 386585 CDS NP_308681.1 15829908 917014 complement(729393..730925) 1 NC_002695.1 similar to CITF_ECOLI gi|1786832 (conserved in Escherichia coli K-12); citrate lyase subunit alpha 730925 917014 ECs0654 Escherichia coli O157:H7 str. Sakai citrate lyase subunit alpha NP_308681.1 729393 R 386585 CDS NP_308682.2 38703883 917015 complement(730936..731844) 1 NC_002695.1 similar to CITE_ECOLI gi|1786833 (conserved in Escherichia coli K-12); citrate lyase subunit beta 731844 917015 ECs0655 Escherichia coli O157:H7 str. Sakai citrate lyase subunit beta NP_308682.2 730936 R 386585 CDS NP_308683.1 15829910 917016 complement(731841..732137) 1 NC_002695.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 732137 917016 ECs0656 Escherichia coli O157:H7 str. Sakai citrate lyase subunit gamma NP_308683.1 731841 R 386585 CDS NP_308684.2 38703884 917017 complement(732152..733210) 1 NC_002695.1 similar to CITC_ECOLI gi|1786835 (conserved in Escherichia coli K-12); citrate lyase synthetase 733210 917017 ECs0657 Escherichia coli O157:H7 str. Sakai citrate lyase synthetase NP_308684.2 732152 R 386585 CDS NP_308685.1 15829912 917018 733590..735248 1 NC_002695.1 similar to CITA_ECOLI gi|1786837 (conserved in Escherichia coli K-12); sensor-type protein 735248 917018 ECs0658 Escherichia coli O157:H7 str. Sakai sensor-type protein NP_308685.1 733590 D 386585 CDS NP_308686.1 15829913 917019 735217..735897 1 NC_002695.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 735897 dpiA 917019 dpiA Escherichia coli O157:H7 str. Sakai two-component response regulator DpiA NP_308686.1 735217 D 386585 CDS NP_308687.1 15829914 917020 complement(735938..737323) 1 NC_002695.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 737323 dcuC 917020 dcuC Escherichia coli O157:H7 str. Sakai C4-dicarboxylate transporter DcuC NP_308687.1 735938 R 386585 CDS NP_308688.1 15829915 917021 737912..738472 1 NC_002695.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 738472 pagP 917021 pagP Escherichia coli O157:H7 str. Sakai palmitoyl transferase NP_308688.1 737912 D 386585 CDS NP_308689.1 15829916 917022 738647..738856 1 NC_002695.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 738856 cspE 917022 cspE Escherichia coli O157:H7 str. Sakai cold shock protein CspE NP_308689.1 738647 D 386585 CDS NP_308690.1 15829917 917023 complement(738910..739293) 1 NC_002695.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 739293 ccrB 917023 ccrB Escherichia coli O157:H7 str. Sakai camphor resistance protein CrcB NP_308690.1 738910 R 386585 CDS NP_308691.1 15829918 917024 739386..740174 1 NC_002695.1 similar to YBEH_ECOLI gi|1786843, YBEM_ECOLI, gi|1786844; amidase 740174 917024 ECs0664 Escherichia coli O157:H7 str. Sakai amidase NP_308691.1 739386 D 386585 CDS NP_308692.1 15829919 917025 740303..740506 1 NC_002695.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 740506 tatE 917025 tatE Escherichia coli O157:H7 str. Sakai twin arginine translocase E NP_308692.1 740303 D 386585 CDS NP_308693.1 15829920 917026 complement(740607..741572) 1 NC_002695.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 741572 917026 ECs0666 Escherichia coli O157:H7 str. Sakai lipoyl synthase NP_308693.1 740607 R 386585 CDS NP_308694.2 38703885 917027 complement(741781..742734) 1 NC_002695.1 similar to YBEF_ECOLI gi|1786847 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 742734 917027 ECs0667 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_308694.2 741781 R 386585 CDS NP_308695.2 162139805 917028 complement(742994..743635) 1 NC_002695.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 743635 lipB 917028 lipB Escherichia coli O157:H7 str. Sakai lipoate-protein ligase B NP_308695.2 742994 R 386585 CDS NP_308696.1 15829923 917029 complement(743736..743999) 1 NC_002695.1 similar to YBED_ECOLI gi|1786850 (conserved in Escherichia coli K-12); hypothetical protein 743999 917029 ECs0669 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308696.1 743736 R 386585 CDS NP_308697.1 15829924 917030 complement(744109..745320) 1 NC_002695.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 745320 917030 ECs0670 Escherichia coli O157:H7 str. Sakai D-alanyl-D-alanine carboxypeptidase NP_308697.1 744109 R 386585 CDS NP_308698.1 15829925 917032 complement(745460..746548) 1 NC_002695.1 similar to RLPA_ECOLI gi|1786852 (conserved in Escherichia coli K-12); rare lipoprotein A 746548 917032 ECs0671 Escherichia coli O157:H7 str. Sakai rare lipoprotein A NP_308698.1 745460 R 386585 CDS NP_308699.1 15829926 917033 complement(746559..747671) 1 NC_002695.1 similar to MRDB_ECOLI gi|1786853 (conserved in Escherichia coli K-12); cell wall shape-determining protein 747671 917033 ECs0672 Escherichia coli O157:H7 str. Sakai cell wall shape-determining protein NP_308699.1 746559 R 386585 CDS NP_308700.1 15829927 917034 complement(747674..749575) 1 NC_002695.1 similar to MRDA_ECOLI gi|1786854 (conserved in Escherichia coli K-12); penicillin-binding protein 2 749575 917034 ECs0673 Escherichia coli O157:H7 str. Sakai penicillin-binding protein 2 NP_308700.1 747674 R 386585 CDS NP_308701.1 15829928 917035 complement(749606..750073) 1 NC_002695.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 750073 917035 ECs0674 Escherichia coli O157:H7 str. Sakai rRNA large subunit methyltransferase NP_308701.1 749606 R 386585 CDS NP_308702.2 38703886 917036 complement(750077..750394) 1 NC_002695.1 similar to YBEB_ECOLI gi|1786856 (conserved in Escherichia coli K-12); hypothetical protein 750394 917036 ECs0675 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308702.2 750077 R 386585 CDS NP_308703.1 15829930 917037 complement(750654..751265) 1 NC_002695.1 similar to PHPB_ECOLI gi|1786857 (conserved in Escherichia coli K-12); phosphohistidine protein; PhpB 751265 917037 ECs0676 Escherichia coli O157:H7 str. Sakai PhpB NP_308703.1 750654 R 386585 CDS NP_308704.1 15829931 917038 complement(751289..751930) 1 NC_002695.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 751930 nadD 917038 nadD Escherichia coli O157:H7 str. Sakai nicotinic acid mononucleotide adenylyltransferase NP_308704.1 751289 R 386585 CDS NP_308705.1 15829932 917039 complement(751932..752963) 1 NC_002695.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 752963 holA 917039 holA Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit delta NP_308705.1 751932 R 386585 CDS NP_308706.1 15829933 917040 complement(752963..753544) 1 NC_002695.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 753544 917040 ECs0679 Escherichia coli O157:H7 str. Sakai LPS-assembly lipoprotein RlpB NP_308706.1 752963 R 386585 CDS NP_308707.1 15829934 917041 complement(753559..756141) 1 NC_002695.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 756141 leuS 917041 leuS Escherichia coli O157:H7 str. Sakai leucyl-tRNA synthetase NP_308707.1 753559 R 386585 CDS NP_308708.1 15829935 917042 756377..756859 1 NC_002695.1 similar to YBEL_ECOLI gi|1786863 (conserved in Escherichia coli K-12); hypothetical protein 756859 917042 ECs0681 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308708.1 756377 D 386585 CDS NP_308709.1 15829936 917043 complement(756929..757516) 1 NC_002695.1 similar to YBEQ_ECOLI gi|1786864; hypothetical protein 757516 917043 ECs0682 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308709.1 756929 R 386585 CDS NP_308710.1 15829937 917044 758071..758778 1 NC_002695.1 similar to YBER_ECOLI gi|1786865 (conserved in Escherichia coli K-12); hypothetical protein 758778 917044 ECs0683 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308710.1 758071 D 386585 CDS NP_308711.1 15829938 917045 758775..760202 1 NC_002695.1 similar to YBES_ECOLI gi|1786866 (conserved in Escherichia coli K-12); hypothetical protein 760202 917045 ECs0684 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308711.1 758775 D 386585 CDS NP_308712.1 15829939 917046 complement(760212..760766) 1 NC_002695.1 similar to YBET_ECOLI gi|1786867 (conserved in Escherichia coli K-12); hypothetical protein 760766 917046 ECs0685 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308712.1 760212 R 386585 CDS NP_308713.1 15829940 917047 760868..761575 1 NC_002695.1 similar to YBEU_ECOLI gi|1786868 (conserved in Escherichia coli K-12); tRNA ligase 761575 917047 ECs0686 Escherichia coli O157:H7 str. Sakai tRNA ligase NP_308713.1 760868 D 386585 CDS NP_308716.1 15829943 917050 complement(763083..764753) 1 NC_002695.1 similar to YBEW_ECOLI gi|1786870 (conserved in Escherichia coli K-12); molecular chaperone DnaK 764753 917050 ECs0689 Escherichia coli O157:H7 str. Sakai molecular chaperone DnaK NP_308716.1 763083 R 386585 CDS NP_308717.1 15829944 917051 complement(764837..765772) 1 NC_002695.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 765772 rihA 917051 rihA Escherichia coli O157:H7 str. Sakai ribonucleoside hydrolase 1 NP_308717.1 764837 R 386585 CDS NP_308718.1 15829945 917052 complement(765890..766615) 1 NC_002695.1 similar to GLTL_ECOLI gi|1786872 (conserved in Escherichia coli K-12); glutamate/aspartate ABC transporter ATP-binding protein 766615 917052 ECs0691 Escherichia coli O157:H7 str. Sakai glutamate/aspartate ABC transporter ATP-binding protein NP_308718.1 765890 R 386585 CDS NP_308719.1 15829946 917053 complement(766615..767289) 1 NC_002695.1 similar to GLTK_ECOLI gi|1786873 (conserved in Escherichia coli K-12); glutamate/aspartate transport system permease 767289 917053 ECs0692 Escherichia coli O157:H7 str. Sakai glutamate/aspartate transport system permease NP_308719.1 766615 R 386585 CDS NP_308720.1 15829947 917054 complement(767289..768029) 1 NC_002695.1 similar to GLTJ_ECOLI gi|1786874 (conserved in Escherichia coli K-12); glutamate/aspartate transport system permease 768029 917054 ECs0693 Escherichia coli O157:H7 str. Sakai glutamate/aspartate transport system permease NP_308720.1 767289 R 386585 CDS NP_308721.1 15829948 917055 complement(768199..769107) 1 NC_002695.1 similar to YBEJ_ECOLI gi|1786876 (conserved in Escherichia coli K-12); glutamate and aspartate transporter subunit 769107 917055 ECs0694 Escherichia coli O157:H7 str. Sakai glutamate and aspartate transporter subunit NP_308721.1 768199 R 386585 CDS NP_308722.1 15829949 917056 complement(769504..771042) 1 NC_002695.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 771042 lnt 917056 lnt Escherichia coli O157:H7 str. Sakai apolipoprotein N-acyltransferase NP_308722.1 769504 R 386585 CDS NP_308723.1 15829950 917057 complement(771067..771945) 1 NC_002695.1 similar to YBEX_ECOLI gi|1786879 (conserved in Escherichia coli K-12); transporter 771945 917057 ECs0696 Escherichia coli O157:H7 str. Sakai transporter NP_308723.1 771067 R 386585 CDS NP_308724.1 15829951 917058 complement(772035..772502) 1 NC_002695.1 similar to YBEY_ECOLI gi|1786880 (conserved in Escherichia coli K-12); metalloprotease 772502 917058 ECs0697 Escherichia coli O157:H7 str. Sakai metalloprotease NP_308724.1 772035 R 386585 CDS NP_308725.1 15829952 917059 complement(772499..773578) 1 NC_002695.1 similar to YBEZ_ECOLI gi|1786881 (conserved in Escherichia coli K-12); ATP-binding protein in pho regulon 773578 917059 ECs0698 Escherichia coli O157:H7 str. Sakai ATP-binding protein in pho regulon NP_308725.1 772499 R 386585 CDS NP_308726.1 15829953 917060 complement(773692..775116) 1 NC_002695.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 775116 917060 ECs0699 Escherichia coli O157:H7 str. Sakai (dimethylallyl)adenosine tRNA methylthiotransferase NP_308726.1 773692 R 386585 CDS NP_308727.1 15829954 917062 775262..776437 1 NC_002695.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 776437 ubiF 917062 ubiF Escherichia coli O157:H7 str. Sakai 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase NP_308727.1 775262 D 386585 CDS NP_308731.1 15829958 917073 complement(777676..779340) 1 NC_002695.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 779340 asnB 917073 asnB Escherichia coli O157:H7 str. Sakai asparagine synthetase B NP_308731.1 777676 R 386585 CDS NP_308732.1 15829959 917074 complement(779597..780349) 1 NC_002695.1 similar to NAGD_ECOLI gi|1786890 (conserved in Escherichia coli K-12); UMP phosphatase 780349 917074 ECs0705 Escherichia coli O157:H7 str. Sakai UMP phosphatase NP_308732.1 779597 R 386585 CDS NP_308733.1 15829960 917075 complement(780397..781617) 1 NC_002695.1 nag repressor; similar to NAGC_ECOLI gi|1786891 (conserved in Escherichia coli K-12); transcriptional repressor of N-acetylglucosamine operon 781617 917075 ECs0706 Escherichia coli O157:H7 str. Sakai transcriptional repressor of N-acetylglucosamine operon NP_308733.1 780397 R 386585 CDS NP_308734.1 15829961 917076 complement(781626..782774) 1 NC_002695.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 782774 nagA 917076 nagA Escherichia coli O157:H7 str. Sakai N-acetylglucosamine-6-phosphate deacetylase NP_308734.1 781626 R 386585 CDS NP_308735.1 15829962 917077 complement(782834..783634) 1 NC_002695.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 783634 nagB 917077 nagB Escherichia coli O157:H7 str. Sakai glucosamine-6-phosphate deaminase NP_308735.1 782834 R 386585 CDS NP_308736.1 15829963 917078 783967..785913 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 785913 917078 ECs0709 Escherichia coli O157:H7 str. Sakai PTS system N-acetyl glucosamine specific transporter subunit IIABC NP_308736.1 783967 D 386585 CDS NP_308737.1 15829964 917079 786116..787780 1 NC_002695.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 787780 917079 ECs0710 Escherichia coli O157:H7 str. Sakai glutaminyl-tRNA synthetase NP_308737.1 786116 D 386585 CDS NP_308740.1 15829967 917082 789814..790140 1 NC_002695.1 similar to YBFN_ECOLI gi|1786898 (conserved in Escherichia coli K-12); hypothetical protein 790140 917082 ECs0713 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308740.1 789814 D 386585 CDS NP_308741.1 15829968 917083 complement(790224..790670) 1 NC_002695.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 790670 fur 917083 fur Escherichia coli O157:H7 str. Sakai ferric uptake regulator NP_308741.1 790224 R 386585 CDS NP_308742.1 15829969 917084 complement(790959..791489) 1 NC_002695.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 791489 917084 ECs0715 Escherichia coli O157:H7 str. Sakai flavodoxin FldA NP_308742.1 790959 R 386585 CDS NP_308743.1 15829970 917085 complement(791629..791991) 1 NC_002695.1 similar to YBFE_ECOLI gi|1786901 (conserved in Escherichia coli K-12); LexA regulated protein 791991 917085 ECs0716 Escherichia coli O157:H7 str. Sakai LexA regulated protein NP_308743.1 791629 R 386585 CDS NP_308744.1 15829971 917086 complement(792062..792826) 1 NC_002695.1 similar to YBFF_ECOLI gi|1786902 (conserved in Escherichia coli K-12); hypothetical protein 792826 917086 ECs0717 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308744.1 792062 R 386585 CDS NP_308745.1 15829972 917087 793011..793556 1 NC_002695.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 793556 917087 ECs0718 Escherichia coli O157:H7 str. Sakai replication initiation regulator SeqA NP_308745.1 793011 D 386585 CDS NP_308746.1 15829973 917088 793582..795222 1 NC_002695.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 795222 917088 ECs0719 Escherichia coli O157:H7 str. Sakai phosphoglucomutase NP_308746.1 793582 D 386585 CDS NP_308747.1 15829974 917089 complement(795279..796598) 1 NC_002695.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 796598 potE 917089 potE Escherichia coli O157:H7 str. Sakai putrescine transporter NP_308747.1 795279 R 386585 CDS NP_308748.1 15829975 917090 complement(796595..798793) 1 NC_002695.1 similar to SPEF_ECOLI gi|1786909; ornithine decarboxylase 798793 917090 ECs0721 Escherichia coli O157:H7 str. Sakai ornithine decarboxylase NP_308748.1 796595 R 386585 CDS NP_308749.1 15829976 917091 complement(799483..800160) 1 NC_002695.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; KdpE family transcriptional regulator 800160 917091 ECs0722 Escherichia coli O157:H7 str. Sakai KdpE family transcriptional regulator NP_308749.1 799483 R 386585 CDS NP_308750.1 15829977 917092 complement(800157..802841) 1 NC_002695.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 802841 917092 ECs0723 Escherichia coli O157:H7 str. Sakai sensor protein KdpD NP_308750.1 800157 R 386585 CDS NP_308751.1 15829978 917093 complement(802834..803406) 1 NC_002695.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 803406 917093 ECs0724 Escherichia coli O157:H7 str. Sakai potassium-transporting ATPase subunit C NP_308751.1 802834 R 386585 CDS NP_308752.1 15829979 917094 complement(803415..805463) 1 NC_002695.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 805463 917094 ECs0725 Escherichia coli O157:H7 str. Sakai potassium-transporting ATPase subunit B NP_308752.1 803415 R 386585 CDS NP_308753.1 15829980 917095 complement(805486..807159) 1 NC_002695.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 807159 917095 ECs0726 Escherichia coli O157:H7 str. Sakai potassium-transporting ATPase subunit A NP_308753.1 805486 R 386585 CDS NP_308754.1 15829981 917096 complement(807159..807248) 1 NC_002695.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit F 807248 kdpF 917096 kdpF Escherichia coli O157:H7 str. Sakai potassium-transporting ATPase subunit F NP_308754.1 807159 R 386585 CDS NP_308755.1 15829982 917097 807561..807767 1 NC_002695.1 similar to YBFA_ECOLI gi|1786916 (conserved in Escherichia coli K-12); hypothetical protein 807767 917097 ECs0728 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308755.1 807561 D 386585 CDS NP_308756.1 15829983 917098 808009..812208 1 NC_002695.1 core protein with extension; similar to RHSC_ECOLI gi|1786917 and B0703_ECOLI gi|1786921; Rhs protein; protein RhsC 812208 917098 ECs0729 Escherichia coli O157:H7 str. Sakai protein RhsC NP_308756.1 808009 D 386585 CDS NP_308757.1 15829984 917099 812233..812775 1 NC_002695.1 similar to YBFC_ECOLI gi|1786922; hypothetical protein 812775 917099 ECs0730 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308757.1 812233 D 386585 CDS NP_308758.1 15829985 917100 814425..815498 1 NC_002695.1 similar to H-repeat assciated proteins e.g. YHHI_ECOLI gi|1789896 (conserved in Escherichia coli K-12); H repeat-containing protein 815498 917100 ECs0731 Escherichia coli O157:H7 str. Sakai H repeat-containing protein NP_308758.1 814425 D 386585 CDS NP_308759.1 15829986 917101 815647..816156 1 NC_002695.1 similar to YBGA_ECOLI gi|1786925 (conserved in Escherichia coli K-12); hypothetical protein 816156 917101 ECs0732 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308759.1 815647 D 386585 CDS NP_308760.1 15829987 917102 816153..817571 1 NC_002695.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 817571 917102 ECs0733 Escherichia coli O157:H7 str. Sakai deoxyribodipyrimidine photolyase NP_308760.1 816153 D 386585 CDS NP_308761.1 15829988 917103 complement(817721..819202) 1 NC_002695.1 similar to YBGH_ECOLI gi|1786927 (conserved in Escherichia coli K-12); transporter 819202 917103 ECs0734 Escherichia coli O157:H7 str. Sakai transporter NP_308761.1 817721 R 386585 CDS NP_308762.1 15829989 917104 819473..820216 1 NC_002695.1 similar to YBGI_ECOLI gi|1786928 (conserved in Escherichia coli K-12); hydrolase-oxidase 820216 917104 ECs0735 Escherichia coli O157:H7 str. Sakai hydrolase-oxidase NP_308762.1 819473 D 386585 CDS NP_308763.1 15829990 917105 820239..820895 1 NC_002695.1 similar to YBGJ_ECOLI gi|1786929 (conserved in Escherichia coli K-12); carboxylase 820895 917105 ECs0736 Escherichia coli O157:H7 str. Sakai carboxylase NP_308763.1 820239 D 386585 CDS NP_308764.1 15829991 917106 820889..821821 1 NC_002695.1 similar to YBGK_ECOLI gi|1786930 (conserved in Escherichia coli K-12); carboxylase 821821 917106 ECs0737 Escherichia coli O157:H7 str. Sakai carboxylase NP_308764.1 820889 D 386585 CDS NP_308765.1 15829992 917107 821811..822545 1 NC_002695.1 similar to YBGL_ECOLI gi|1786931 (conserved in Escherichia coli K-12); LamB/YcsF family protein 822545 917107 ECs0738 Escherichia coli O157:H7 str. Sakai LamB/YcsF family protein NP_308765.1 821811 D 386585 CDS NP_308766.1 15829993 917108 822581..823372 1 NC_002695.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 823372 917108 ECs0739 Escherichia coli O157:H7 str. Sakai endonuclease VIII NP_308766.1 822581 D 386585 CDS NP_308767.1 15829994 917109 complement(823369..824460) 1 NC_002695.1 similar to ABRB_ECOLI gi|1786933 (conserved in Escherichia coli K-12); transporter 824460 917109 ECs0740 Escherichia coli O157:H7 str. Sakai transporter NP_308767.1 823369 R 386585 CDS NP_308768.1 15829995 917110 complement(824564..825625) 1 NC_002695.1 similar to YBGO_ECOLI gi|1786935; hypothetical protein 825625 917110 ECs0741 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308768.1 824564 R 386585 CDS NP_308769.1 15829996 917111 complement(825622..826353) 1 NC_002695.1 similar to YBGP_ECOLI gi|1786936; chaperone 826353 917111 ECs0742 Escherichia coli O157:H7 str. Sakai chaperone NP_308769.1 825622 R 386585 CDS NP_308770.1 15829997 917476 complement(826656..828827) 1 NC_002695.1 similar to YBGQ_ECOLI gi|1786937; truncated due to frameshift; hypothetical protein 828827 917476 ECs0743 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308770.1 826656 R 386585 CDS NP_308771.1 15829998 917475 complement(828877..829458) 1 NC_002695.1 similar to YBGD_ECOLI gi|1786938; fimbrial-like protein 829458 917475 ECs0744 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_308771.1 828877 R 386585 CDS NP_308772.1 15829999 917477 complement(829830..831113) 1 NC_002695.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 831113 gltA 917477 gltA Escherichia coli O157:H7 str. Sakai type II citrate synthase NP_308772.1 829830 R 386585 CDS NP_308773.1 15830000 917493 831822..832211 1 NC_002695.1 similar to SDHC_ECOLI gi|1786940 (conserved in Escherichia coli K-12); succinate dehydrogenase cytochrome b556 large membrane subunit 832211 sdhC 917493 sdhC Escherichia coli O157:H7 str. Sakai succinate dehydrogenase cytochrome b556 large membrane subunit NP_308773.1 831822 D 386585 CDS NP_308774.1 15830001 917478 832205..832552 1 NC_002695.1 similar to SDHD_ECOLI gi|1786941 (conserved in Escherichia coli K-12); succinate dehydrogenase cytochrome b556 small membrane subunit 832552 sdhD 917478 sdhD Escherichia coli O157:H7 str. Sakai succinate dehydrogenase cytochrome b556 small membrane subunit NP_308774.1 832205 D 386585 CDS NP_308775.1 15830002 917480 832552..834318 1 NC_002695.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 834318 sdhA 917480 sdhA Escherichia coli O157:H7 str. Sakai succinate dehydrogenase flavoprotein subunit NP_308775.1 832552 D 386585 CDS NP_308776.1 15830003 917482 834334..835050 1 NC_002695.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 835050 sdhB 917482 sdhB Escherichia coli O157:H7 str. Sakai succinate dehydrogenase iron-sulfur subunit NP_308776.1 834334 D 386585 CDS NP_308777.1 15830004 917483 835109..835369 1 NC_002695.1 similar to B0725_ECOLI gi|1786944 (conserved in Escherichia coli K-12); hypothetical protein 835369 917483 ECs0750 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308777.1 835109 D 386585 CDS NP_308778.1 15830005 917481 835351..838152 1 NC_002695.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 838152 sucA 917481 sucA Escherichia coli O157:H7 str. Sakai 2-oxoglutarate dehydrogenase E1 NP_308778.1 835351 D 386585 CDS NP_308779.1 15830006 917484 838167..839384 1 NC_002695.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 839384 917484 ECs0752 Escherichia coli O157:H7 str. Sakai dihydrolipoamide succinyltransferase NP_308779.1 838167 D 386585 CDS NP_308780.1 15830007 917490 839478..840644 1 NC_002695.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 840644 sucC 917490 sucC Escherichia coli O157:H7 str. Sakai succinyl-CoA synthetase subunit beta NP_308780.1 839478 D 386585 CDS NP_308781.1 15830008 917489 840644..841513 1 NC_002695.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 841513 917489 ECs0754 Escherichia coli O157:H7 str. Sakai succinyl-CoA synthetase subunit alpha NP_308781.1 840644 D 386585 CDS NP_308782.1 15830009 917485 842180..843085 1 NC_002695.1 similar to transcriptional regulators e.g. glycine cleavage system transcription activator (gcv operon activator) - Escherichia coli gi|417043|sp|P32064|GCVA_ECOLI; transcriptional regulator 843085 917485 ECs0755 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_308782.1 842180 D 386585 CDS NP_308783.1 15830010 917486 complement(843119..843721) 1 NC_002695.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 843721 917486 ECs0756 Escherichia coli O157:H7 str. Sakai cob(I)yrinic acid a,c-diamide adenosyltransferase NP_308783.1 843119 R 386585 CDS NP_308784.1 15830011 917487 complement(843731..845383) 1 NC_002695.1 similar to fumarate hydratase class I, aerobic (fumarase) - Escherichia coli gi|120598|sp|P00923|FUMA_ECOLI; fumarate hydratase 845383 917487 ECs0757 Escherichia coli O157:H7 str. Sakai fumarate hydratase NP_308784.1 843731 R 386585 CDS NP_308785.1 15830012 917488 complement(845491..846771) 1 NC_002695.1 similar to glutamate/aspartate transport proteins (proton glutamate symport proteins) e.g. [Bacillus stearothermophilus] gi|121467|sp|P24943|GLTT_BACST; similar toC4-dicarboxylate transporter; transporter 846771 917488 ECs0758 Escherichia coli O157:H7 str. Sakai transporter NP_308785.1 845491 R 386585 CDS NP_308786.1 15830013 917499 complement(846932..847249) 1 NC_002695.1 hypothetical protein 847249 917499 ECs0759 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308786.1 846932 R 386585 CDS NP_308787.1 15830014 917494 complement(847246..848616) 1 NC_002695.1 hypothetical protein 848616 917494 ECs0760 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308787.1 847246 R 386585 CDS NP_308788.1 15830015 917491 complement(848620..849861) 1 NC_002695.1 beta-methylaspartase; similar to 3-methylaspartate ammonia-lyases (beta-methylaspartases) e.g. [Citrobacter amalonaticus] gi|3184397|dbj|BAA28709.1|; [Clostridium tetanomorphum] gi|729971|sp; 3-methylaspartate ammonia-lyase 849861 917491 ECs0761 Escherichia coli O157:H7 str. Sakai 3-methylaspartate ammonia-lyase NP_308788.1 848620 R 386585 CDS NP_308789.1 15830016 917492 complement(849861..851306) 1 NC_002695.1 methylaspartate mutase E; similar to glutamate mutases e.g. [Citrobacter amalonaticus] gi|3184396|dbj|BAA28708.1|; [Clostridium tetanomorphum] gi|729586|sp|Q05509|GLME_CLOTT; glutamate mutase E 851306 917492 ECs0762 Escherichia coli O157:H7 str. Sakai glutamate mutase E NP_308789.1 849861 R 386585 CDS NP_308790.1 15830017 917495 complement(851325..852713) 1 NC_002695.1 methylaspartate mutase L; similar to glutamate mutase L (methylaspartate mutase L) e.g. [Clostridium tetanomorphum] gi|444421|prf||1907157C; glutamate mutase L 852713 917495 ECs0763 Escherichia coli O157:H7 str. Sakai glutamate mutase L NP_308790.1 851325 R 386585 CDS NP_308791.1 15830018 917503 complement(852713..853162) 1 NC_002695.1 converts methylaspartate to L-glutamate; methylaspartate mutase subunit S 853162 917503 ECs0764 Escherichia coli O157:H7 str. Sakai methylaspartate mutase subunit S NP_308791.1 852713 R 386585 CDS NP_308793.1 15830020 917498 complement(853710..854132) 1 NC_002695.1 hypothetical protein 854132 917498 ECs0766 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308793.1 853710 R 386585 CDS NP_308794.1 15830021 917497 complement(854214..855158) 1 NC_002695.1 hypothetical protein 855158 917497 ECs0767 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308794.1 854214 R 386585 CDS NP_308795.1 15830022 917512 855961..857532 1 NC_002695.1 similar to CYDA_ECOLI gi|1786953 (conserved in Escherichia coli K-12); cytochrome d terminal oxidase polypeptide subunit I 857532 917512 ECs0768 Escherichia coli O157:H7 str. Sakai cytochrome d terminal oxidase polypeptide subunit I NP_308795.1 855961 D 386585 CDS NP_308796.1 15830023 917500 857548..858687 1 NC_002695.1 similar to CYDB_ECOLI gi|1786954 (conserved in Escherichia coli K-12); cytochrome d terminal oxidase polypeptide subunit II 858687 917500 ECs0769 Escherichia coli O157:H7 str. Sakai cytochrome d terminal oxidase polypeptide subunit II NP_308796.1 857548 D 386585 CDS NP_944510.1 38703887 2693749 858702..858815 1 NC_002695.1 hypothetical protein 858815 2693749 ECs5391 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944510.1 858702 D 386585 CDS NP_308797.1 15830024 917502 858815..859108 1 NC_002695.1 similar to YBGE_ECOLI gi|1786956 (conserved in Escherichia coli K-12); hypothetical protein 859108 917502 ECs0770 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308797.1 858815 D 386585 CDS NP_308798.1 15830025 917501 859258..859662 1 NC_002695.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 859662 917501 ECs0771 Escherichia coli O157:H7 str. Sakai acyl-CoA thioester hydrolase NP_308798.1 859258 D 386585 CDS NP_308799.1 15830026 917505 859659..860351 1 NC_002695.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 860351 917505 ECs0772 Escherichia coli O157:H7 str. Sakai colicin uptake protein TolQ NP_308799.1 859659 D 386585 CDS NP_308800.1 15830027 917504 860355..860783 1 NC_002695.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 860783 917504 ECs0773 Escherichia coli O157:H7 str. Sakai colicin uptake protein TolR NP_308800.1 860355 D 386585 CDS NP_308801.1 15830028 917507 860848..862032 1 NC_002695.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 862032 tolA 917507 tolA Escherichia coli O157:H7 str. Sakai cell envelope integrity inner membrane protein TolA NP_308801.1 860848 D 386585 CDS NP_308802.1 15830029 917506 862165..863457 1 NC_002695.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 863457 tolB 917506 tolB Escherichia coli O157:H7 str. Sakai translocation protein TolB NP_308802.1 862165 D 386585 CDS NP_308803.1 15830030 917510 863492..864013 1 NC_002695.1 similar to PAL_ECOLI gi|1786962 (conserved in Escherichia coli K-12); peptidoglycan-associated outer membrane lipoprotein 864013 917510 ECs0776 Escherichia coli O157:H7 str. Sakai peptidoglycan-associated outer membrane lipoprotein NP_308803.1 863492 D 386585 CDS NP_308804.1 15830031 917508 864023..864814 1 NC_002695.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 864814 917508 ECs0777 Escherichia coli O157:H7 str. Sakai tol-pal system protein YbgF NP_308804.1 864023 D 386585 CDS NP_308805.1 15830032 917516 865949..866992 1 NC_002695.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 866992 917516 ECs0778 Escherichia coli O157:H7 str. Sakai quinolinate synthetase NP_308805.1 865949 D 386585 CDS NP_308806.1 15830033 917520 867030..867749 1 NC_002695.1 similar to PNUC_ECOLI gi|1786965 (conserved in Escherichia coli K-12); protein PnuC 867749 917520 ECs0779 Escherichia coli O157:H7 str. Sakai protein PnuC NP_308806.1 867030 D 386585 CDS NP_308807.1 15830034 917515 complement(867746..868687) 1 NC_002695.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 868687 917515 ECs0780 Escherichia coli O157:H7 str. Sakai zinc transporter ZitB NP_308807.1 867746 R 386585 CDS NP_308808.1 15830035 917518 complement(868801..869181) 1 NC_002695.1 similar to B0753_ECOLI gi|1786968 (conserved in Escherichia coli K-12); homeobox protein 869181 917518 ECs0781 Escherichia coli O157:H7 str. Sakai homeobox protein NP_308808.1 868801 R 386585 CDS NP_308809.1 15830036 917531 869497..870549 1 NC_002695.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 870549 917531 ECs0782 Escherichia coli O157:H7 str. Sakai phospho-2-dehydro-3-deoxyheptonate aldolase NP_308809.1 869497 D 386585 CDS NP_308810.1 15830037 917517 complement(870715..871467) 1 NC_002695.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 871467 gpmA 917517 gpmA Escherichia coli O157:H7 str. Sakai phosphoglyceromutase NP_308810.1 870715 R 386585 CDS NP_308811.1 15830038 917521 complement(871669..872709) 1 NC_002695.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 872709 galM 917521 galM Escherichia coli O157:H7 str. Sakai aldose 1-epimerase NP_308811.1 871669 R 386585 CDS NP_308812.1 15830039 917523 complement(872703..873851) 1 NC_002695.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 873851 917523 ECs0785 Escherichia coli O157:H7 str. Sakai galactokinase NP_308812.1 872703 R 386585 CDS NP_308813.1 15830040 917530 complement(873855..874901) 1 NC_002695.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 874901 917530 ECs0786 Escherichia coli O157:H7 str. Sakai galactose-1-phosphate uridylyltransferase NP_308813.1 873855 R 386585 CDS NP_308814.2 38703888 917525 complement(874911..875939) 1 NC_002695.1 similar to GALE_ECOLI gi|1786974 (conserved in Escherichia coli K-12); UDP-galactose-4-epimerase 875939 917525 ECs0787 Escherichia coli O157:H7 str. Sakai UDP-galactose-4-epimerase NP_308814.2 874911 R 386585 CDS NP_308815.1 15830042 917552 complement(876189..877661) 1 NC_002695.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 877661 917552 ECs0788 Escherichia coli O157:H7 str. Sakai molybdenum transport ATP-binding protein ModF NP_308815.1 876189 R 386585 CDS NP_308816.1 15830043 917526 complement(877729..878517) 1 NC_002695.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; ModE family transcriptional regulator 878517 917526 ECs0789 Escherichia coli O157:H7 str. Sakai ModE family transcriptional regulator NP_308816.1 877729 R 386585 CDS NP_308817.1 15830044 917527 878646..878795 1 NC_002695.1 similar to B0762_ECOLI gi|1786977 (conserved in Escherichia coli K-12); hypothetical protein 878795 917527 ECs0790 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308817.1 878646 D 386585 CDS NP_308818.1 15830045 917528 878962..879735 1 NC_002695.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 879735 modA 917528 modA Escherichia coli O157:H7 str. Sakai molybdate transporter periplasmic protein NP_308818.1 878962 D 386585 CDS NP_308819.1 15830046 917529 879735..880424 1 NC_002695.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 880424 modB 917529 modB Escherichia coli O157:H7 str. Sakai molybdate ABC transporter permease NP_308819.1 879735 D 386585 CDS NP_308820.1 15830047 917533 880427..881485 1 NC_002695.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 881485 modC 917533 modC Escherichia coli O157:H7 str. Sakai molybdate transporter ATP-binding protein NP_308820.1 880427 D 386585 CDS NP_308821.1 15830048 917532 complement(881486..882304) 1 NC_002695.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 882304 917532 ECs0794 Escherichia coli O157:H7 str. Sakai phosphotransferase NP_308821.1 881486 R 386585 CDS NP_308822.1 15830049 917534 882459..883454 1 NC_002695.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 883454 917534 ECs0795 Escherichia coli O157:H7 str. Sakai 6-phosphogluconolactonase NP_308822.1 882459 D 386585 CDS NP_308823.2 38703889 917536 complement(883495..884427) 1 NC_002695.1 similar to YBHD_ECOLI gi|1786984 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 884427 917536 ECs0796 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_308823.2 883495 R 386585 CDS NP_308824.1 15830051 917538 884632..885684 1 NC_002695.1 similar to YBHH_ECOLI gi|1786985 (conserved in Escherichia coli K-12); hypothetical protein 885684 917538 ECs0797 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308824.1 884632 D 386585 CDS NP_308825.1 15830052 917537 885760..887193 1 NC_002695.1 similar to YBHI_ECOLI gi|1786986 (conserved in Escherichia coli K-12); membrane pump protein 887193 917537 ECs0798 Escherichia coli O157:H7 str. Sakai membrane pump protein NP_308825.1 885760 D 386585 CDS NP_308826.2 162139804 917535 887376..889637 1 NC_002695.1 similar to YBHJ_ECOLI gi|1786987 (conserved in Escherichia coli K-12); hypothetical protein 889637 917535 ECs0799 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308826.2 887376 D 386585 CDS NP_308827.1 15830054 917540 complement(889778..891061) 1 NC_002695.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase 891061 917540 ECs0800 Escherichia coli O157:H7 str. Sakai pectinesterase NP_308827.1 889778 R 386585 CDS NP_308828.1 15830055 917539 complement(892240..892458) 1 NC_002695.1 similar to excisionase [Bacteriophage HK022] gi|1722835|sp|P11683|VXIS_BP434 and [Bacteriophage lambda] gi|139680|sp|P03699|VXIS_LAMBD; excisionase 892458 917539 ECs0801 Escherichia coli O157:H7 str. Sakai excisionase NP_308828.1 892240 R 386585 CDS NP_308829.1 15830056 917541 complement(892498..892665) 1 NC_002695.1 similar to hypothetical protein ORF55 [Bacteriophage 434] gi|801889|gb|AAA67903.1; hypothetical protein 892665 917541 ECs0802 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308829.1 892498 R 386585 CDS NP_308831.1 15830058 917548 892980..893510 1 NC_002695.1 hypothetical protein 893510 917548 ECs0804 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308831.1 892980 D 386585 CDS NP_308832.1 15830059 917542 complement(893721..893942) 1 NC_002695.1 similar to C4-type zinc finger proteins (TraR family) e.g. gi|7649830|dbj|BAA94108.1; hypothetical protein 893942 917542 ECs0805 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308832.1 893721 R 386585 CDS NP_308833.2 38703890 917543 complement(894041..894256) 1 NC_002695.1 hypothetical protein 894256 917543 ECs0806 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308833.2 894041 R 386585 CDS NP_308834.1 15830061 917546 complement(894333..894524) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881603|dbj|BAA84294.1, orf63 [Bacteriophage lambda] gi|508994|gb|AAA96567.1; hypothetical protein 894524 917546 ECs0807 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308834.1 894333 R 386585 CDS NP_308835.1 15830062 917547 complement(894497..894679) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585389|gb|AAD25417.1|AF125520_12, orf60a [Bacteriophage lambda] gi|508995|gb|AAA96568.1; hypothetical protein 894679 917547 ECs0808 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308835.1 894497 R 386585 CDS NP_308836.1 15830063 917544 complement(894676..895356) 1 NC_002695.1 similar to exonucleases e.g. [Bacteriophage lambda] gi|119702|sp|P03697|EXO_LAMBD; exonuclease 895356 917544 ECs0809 Escherichia coli O157:H7 str. Sakai exonuclease NP_308836.1 894676 R 386585 CDS NP_944511.1 38703891 2693773 complement(895353..895997) 1 NC_002695.1 hypothetical protein 895997 2693773 ECs5398 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944511.1 895353 R 386585 CDS NP_308837.1 15830064 917551 896054..896236 1 NC_002695.1 similar to NinE [Bacteriophage 21] gi|4539480|emb|CAB39989.1; protein NinE 896236 917551 ECs0810 Escherichia coli O157:H7 str. Sakai protein NinE NP_308837.1 896054 D 386585 CDS NP_308838.1 15830065 917550 896233..896403 1 NC_002695.1 similar to NinF [Bacteriophage 21] gi|4539481|emb|CAB39990.1|; protein NinF 896403 917550 ECs0811 Escherichia coli O157:H7 str. Sakai protein NinF NP_308838.1 896233 D 386585 CDS NP_308839.1 15830066 917549 896393..897016 1 NC_002695.1 similar to NinG [Bacteriophage 21] gi|4539482|emb|CAB39991.1; protein NinG 897016 917549 ECs0812 Escherichia coli O157:H7 str. Sakai protein NinG NP_308839.1 896393 D 386585 CDS NP_308840.1 15830067 917554 897013..897678 1 NC_002695.1 similar to serine/threonin protein phosphatases e.g. [Bacteriophage lambda] gi|130792|sp|P03772|PP_LAMBD; serine/threonin protein phosphatase 897678 917554 ECs0813 Escherichia coli O157:H7 str. Sakai serine/threonin protein phosphatase NP_308840.1 897013 D 386585 CDS NP_308841.1 15830068 917556 complement(897890..898849) 1 NC_002695.1 similar to probable outer membrane protein [Helicobacter pylori (strain J99)] gi|7465285|pir||H71907; outer membrane protein 898849 917556 ECs0814 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_308841.1 897890 R 386585 CDS NP_308842.1 15830069 917555 899324..900013 1 NC_002695.1 similar to antiterminators e.g. protein Q [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; anti-termination protein 900013 917555 ECs0815 Escherichia coli O157:H7 str. Sakai anti-termination protein NP_308842.1 899324 D 386585 CDS NP_308843.2 38703892 917576 900224..900940 1 NC_002695.1 similar to orf14 [Actinobacillus actinomycetemcomitans] gi|7592819|dbj|BAA94406.1, TfpB protein [Moraxella bovis] gi|141258|sp|P20666|TFPB_MORBO; hypothetical protein 900940 917576 ECs0816 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308843.2 900224 D 386585 CDS NP_308845.1 15830072 917559 901806..902021 1 NC_002695.1 similar to holin S e .g. [Bacteriophage 933W] gi|4499808|emb|CAB39307.1; holin 902021 917559 ECs0818 Escherichia coli O157:H7 str. Sakai holin NP_308845.1 901806 D 386585 CDS NP_308846.1 15830073 917557 902021..902518 1 NC_002695.1 lysozyme; similar to endolysins (lysozyme) e.g. R protein [Bacteriophage 21] gi|67436|pir||LZBP21; endolysin 902518 917557 ECs0819 Escherichia coli O157:H7 str. Sakai endolysin NP_308846.1 902021 D 386585 CDS NP_308847.1 15830074 917558 902515..902982 1 NC_002695.1 similar to hypothetical protein gp15 [Bacteriophage PS119] gi|3676087|emb|CAA09711.1, endopeptidases e.g. [Bacteriophage lambda] gi|67522|pir||APBPML ident; endopeptidase 902982 917558 ECs0820 Escherichia coli O157:H7 str. Sakai endopeptidase NP_308847.1 902515 D 386585 CDS NP_308849.1 15830076 917574 902970..903122 1 NC_002695.1 hypothetical protein 903122 917574 ECs0822 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308849.1 902970 D 386585 CDS NP_308850.1 15830077 917563 903529..903807 1 NC_002695.1 hypothetical protein 903807 917563 ECs0823 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308850.1 903529 D 386585 CDS NP_308851.1 15830078 917565 903797..904288 1 NC_002695.1 hypothetical protein 904288 917565 ECs0824 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308851.1 903797 D 386585 CDS NP_308852.1 15830079 917567 904288..906390 1 NC_002695.1 similar to terminase large subunits e.g. [Bacteriophage WO] gi|6723224|dbj|BAA89621.1, [Bacteriophage N15] gi|7444579|pir||T13088; terminase large subunit 906390 917567 ECs0825 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_308852.1 904288 D 386585 CDS NP_308853.1 15830080 917601 906387..906599 1 NC_002695.1 hypothetical protein 906599 917601 ECs0826 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308853.1 906387 D 386585 CDS NP_308854.1 15830081 917561 906527..907651 1 NC_002695.1 similar to portal protein [Wolbachia sp. wKue]gi|6723246|dbj|BAA89642.1|; portal protein 907651 917561 ECs0827 Escherichia coli O157:H7 str. Sakai portal protein NP_308854.1 906527 D 386585 CDS NP_308855.1 15830082 917564 907851..908108 1 NC_002695.1 hypothetical protein 908108 917564 ECs0828 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308855.1 907851 D 386585 CDS NP_308856.1 15830083 917566 907957..910080 1 NC_002695.1 similar to scaffolding protein [Streptococcus thermophilus bacteriophage DT1] gi|4530143|gb|AAD21883.1, probable protease/scaffold protein, ClpP protease e.g. [Bacteriophage D3] gi|5059251|gb|AAD38956.1; protease/scaffold protein 910080 917566 ECs0829 Escherichia coli O157:H7 str. Sakai protease/scaffold protein NP_308856.1 907957 D 386585 CDS NP_308857.1 15830084 917568 910122..910490 1 NC_002695.1 hypothetical protein 910490 917568 ECs0830 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308857.1 910122 D 386585 CDS NP_308858.1 15830085 917570 910483..910758 1 NC_002695.1 hypothetical protein 910758 917570 ECs0831 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308858.1 910483 D 386585 CDS NP_308859.1 15830086 917569 910770..911348 1 NC_002695.1 similar to minor tail proteins e.g. protein Z [Bacteriophage N15] gi|7521219|pir||T13097, GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein 911348 917569 ECs0832 Escherichia coli O157:H7 str. Sakai minor tail protein NP_308859.1 910770 D 386585 CDS NP_308860.1 15830087 917571 911345..911746 1 NC_002695.1 similar to minor tail proteins e.g. protein U [Bacteriophage N15] gi|7444588|pir||T13098, GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein 911746 917571 ECs0833 Escherichia coli O157:H7 str. Sakai minor tail protein NP_308860.1 911345 D 386585 CDS NP_308861.1 15830088 917575 911757..912500 1 NC_002695.1 similar to major tail proteins e.g. protein V [Bacteriophage N15] gi|7444589|pir||T13099, GpV [Bacteriophage lambda] gi|138848|sp|P03733|VMTV_LAMBD; major tail protein 912500 917575 ECs0834 Escherichia coli O157:H7 str. Sakai major tail protein NP_308861.1 911757 D 386585 CDS NP_308862.1 15830089 917572 912561..912947 1 NC_002695.1 similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 912947 917572 ECs0835 Escherichia coli O157:H7 str. Sakai minor tail protein NP_308862.1 912561 D 386585 CDS NP_308863.1 15830090 917581 912956..913285 1 NC_002695.1 similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein 913285 917581 ECs0836 Escherichia coli O157:H7 str. Sakai minor tail protein NP_308863.1 912956 D 386585 CDS NP_308864.1 15830091 917573 913257..916322 1 NC_002695.1 similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 916322 917573 ECs0837 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_308864.1 913257 D 386585 CDS NP_308865.1 15830092 917577 916322..916651 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 916651 917577 ECs0838 Escherichia coli O157:H7 str. Sakai minor tail protein NP_308865.1 916322 D 386585 CDS NP_308866.1 15830093 917583 916661..917359 1 NC_002695.1 similar to GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 917359 917583 ECs0839 Escherichia coli O157:H7 str. Sakai minor tail protein NP_308866.1 916661 D 386585 CDS NP_308867.1 15830094 917579 917509..918108 1 NC_002695.1 similar to GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 918108 917579 ECs0840 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_308867.1 917509 D 386585 CDS NP_308868.1 15830095 917580 918006..918653 1 NC_002695.1 similar to GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 918653 917580 ECs0841 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_308868.1 918006 D 386585 CDS NP_308869.1 15830096 917578 918714..922127 1 NC_002695.1 similar to GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 922127 917578 ECs0842 Escherichia coli O157:H7 str. Sakai host specificity protein NP_308869.1 918714 D 386585 CDS NP_308870.1 15830097 917582 922198..922797 1 NC_002695.1 similar to outer membrane protein Lom precursors e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein 922797 917582 ECs0843 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_308870.1 922198 D 386585 CDS NP_308871.1 15830098 917584 922857..924173 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 924173 917584 ECs0844 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_308871.1 922857 D 386585 CDS NP_308872.1 15830099 917586 924136..924444 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 924444 917586 ECs0845 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308872.1 924136 D 386585 CDS NP_308873.1 15830100 917585 924621..925601 1 NC_002695.1 similar to hypothetical protein [Salmonella typhimurium LT2] gi|6960367|gb|AAF33527.1; hypothetical protein 925601 917585 ECs0846 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308873.1 924621 D 386585 CDS NP_308874.1 15830101 917594 925662..926654 1 NC_002695.1 hypothetical protein 926654 917594 ECs0847 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308874.1 925662 D 386585 CDS NP_308875.1 15830102 917591 927482..928363 1 NC_002695.1 hypothetical protein 928363 917591 ECs0848 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308875.1 927482 D 386585 CDS NP_308876.1 15830103 917597 928398..928532 1 NC_002695.1 hypothetical protein 928532 917597 ECs0849 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308876.1 928398 D 386585 CDS NP_308877.1 15830104 917593 928594..929292 1 NC_002695.1 hypothetical protein 929292 917593 ECs0850 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308877.1 928594 D 386585 CDS NP_308878.1 15830105 917596 complement(929799..930275) 1 NC_002695.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 930275 917596 ECs0851 Escherichia coli O157:H7 str. Sakai kinase inhibitor protein NP_308878.1 929799 R 386585 CDS NP_308879.1 15830106 917588 complement(930334..931623) 1 NC_002695.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 931623 917588 ECs0852 Escherichia coli O157:H7 str. Sakai adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_308879.1 930334 R 386585 CDS NP_308880.1 15830107 917589 931710..932750 1 NC_002695.1 similar to BIOB_ECOLI gi|1786992 (conserved in Escherichia coli K-12); biotin synthase 932750 917589 ECs0853 Escherichia coli O157:H7 str. Sakai biotin synthase NP_308880.1 931710 D 386585 CDS NP_308881.1 15830108 917598 932747..933901 1 NC_002695.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 933901 917598 ECs0854 Escherichia coli O157:H7 str. Sakai 8-amino-7-oxononanoate synthase NP_308881.1 932747 D 386585 CDS NP_308882.1 15830109 917590 933888..934643 1 NC_002695.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 934643 917590 ECs0855 Escherichia coli O157:H7 str. Sakai biotin biosynthesis protein BioC NP_308882.1 933888 D 386585 CDS NP_308883.1 15830110 917592 934636..935313 1 NC_002695.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 935313 bioD 917592 bioD Escherichia coli O157:H7 str. Sakai dithiobiotin synthetase NP_308883.1 934636 D 386585 CDS NP_308884.1 15830111 917595 935892..937913 1 NC_002695.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 937913 917595 ECs0857 Escherichia coli O157:H7 str. Sakai excinuclease ABC subunit B NP_308884.1 935892 D 386585 CDS NP_308885.1 15830112 917602 complement(938104..939012) 1 NC_002695.1 similar to YBHK_ECOLI gi|1786997 (conserved in Escherichia coli K-12); structural protein 939012 917602 ECs0858 Escherichia coli O157:H7 str. Sakai structural protein NP_308885.1 938104 R 386585 CDS NP_308886.1 15830113 917600 939409..940398 1 NC_002695.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 940398 moaA 917600 moaA Escherichia coli O157:H7 str. Sakai molybdenum cofactor biosynthesis protein A NP_308886.1 939409 D 386585 CDS NP_308887.1 15830114 917603 940420..940932 1 NC_002695.1 similar to MOAB_ECOLI gi|1787000 (conserved in Escherichia coli K-12); molybdenum cofactor biosynthesis protein B 940932 917603 ECs0860 Escherichia coli O157:H7 str. Sakai molybdenum cofactor biosynthesis protein B NP_308887.1 940420 D 386585 CDS NP_308888.1 15830115 917613 940935..941420 1 NC_002695.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 941420 moaC 917613 moaC Escherichia coli O157:H7 str. Sakai molybdenum cofactor biosynthesis protein MoaC NP_308888.1 940935 D 386585 CDS NP_308889.1 15830116 917604 941413..941658 1 NC_002695.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 941658 moaD 917604 moaD Escherichia coli O157:H7 str. Sakai molybdopterin synthase small subunit NP_308889.1 941413 D 386585 CDS NP_308890.1 15830117 917599 941660..942112 1 NC_002695.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 942112 moaE 917599 moaE Escherichia coli O157:H7 str. Sakai molybdopterin guanine dinucleotide biosynthesis protein MoaE NP_308890.1 941660 D 386585 CDS NP_308891.1 15830118 917612 942248..942952 1 NC_002695.1 similar to YBHL_ECOLI gi|1787004 (conserved in Escherichia coli K-12); hypothetical protein 942952 917612 ECs0864 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308891.1 942248 D 386585 CDS NP_308892.1 15830119 917605 943160..943873 1 NC_002695.1 similar to YBHM_ECOLI gi|1787005 (conserved in Escherichia coli K-12); hypothetical protein 943873 917605 ECs0865 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308892.1 943160 D 386585 CDS NP_308893.1 15830120 917606 complement(943909..944865) 1 NC_002695.1 similar to YBHN_ECOLI gi|1787006 (conserved in Escherichia coli K-12); hypothetical protein 944865 917606 ECs0866 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308893.1 943909 R 386585 CDS NP_308894.1 15830121 917609 complement(944865..946106) 1 NC_002695.1 similar to YBHO_ECOLI gi|1787007 (conserved in Escherichia coli K-12); cardiolipin synthase 2 946106 917609 ECs0867 Escherichia coli O157:H7 str. Sakai cardiolipin synthase 2 NP_308894.1 944865 R 386585 CDS NP_308895.1 15830122 917610 complement(946103..946864) 1 NC_002695.1 similar to YBHP_ECOLI gi|1787008 (conserved in Escherichia coli K-12); hypothetical protein 946864 917610 ECs0868 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308895.1 946103 R 386585 CDS NP_308896.1 15830123 917607 946997..947407 1 NC_002695.1 similar to YBHQ_ECOLI gi|1787009 (conserved in Escherichia coli K-12); hypothetical protein 947407 917607 ECs0869 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308896.1 946997 D 386585 CDS NP_308897.1 15830124 917635 complement(947369..948475) 1 NC_002695.1 similar to YBHR_ECOLI gi|1787010 (conserved in Escherichia coli K-12); hypothetical protein 948475 917635 ECs0870 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308897.1 947369 R 386585 CDS NP_308898.1 15830125 917608 complement(948486..949619) 1 NC_002695.1 similar to YBHS_ECOLI gi|1787011 (conserved in Escherichia coli K-12); hypothetical protein 949619 917608 ECs0871 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308898.1 948486 R 386585 CDS NP_308899.2 38703893 917634 complement(949612..951348) 1 NC_002695.1 similar to YBHF_ECOLI gi|1787012 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 951348 917634 ECs0872 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308899.2 949612 R 386585 CDS NP_308900.1 15830127 917611 complement(951341..952339) 1 NC_002695.1 similar to B0795_ECOLI gi|1787013 (conserved in Escherichia coli K-12); hypothetical protein 952339 917611 ECs0873 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308900.1 951341 R 386585 CDS NP_308901.1 15830128 917615 complement(952339..953022) 1 NC_002695.1 similar to YBIH_ECOLI gi|1787014 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 953022 917615 ECs0874 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_308901.1 952339 R 386585 CDS NP_308902.1 15830129 917614 953239..954606 1 NC_002695.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 954606 917614 ECs0875 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase RhlE NP_308902.1 953239 D 386585 CDS NP_308903.1 15830130 917617 955214..957226 1 NC_002695.1 similar to secreted effector protein SopA [Salmonella dublin] gi|5669806|gb|AAD46479.1|AF121227_1 and YjBI [Escherichia coli] gi|418540|sp|P32690|YJBI_ECOLI; hypothetical protein 957226 917617 ECs0876 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308903.1 955214 D 386585 CDS NP_308904.1 15830131 917619 957510..959660 1 NC_002695.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 959660 dinG 917619 dinG Escherichia coli O157:H7 str. Sakai ATP-dependent DNA helicase DinG NP_308904.1 957510 D 386585 CDS NP_308905.1 15830132 917616 959688..960650 1 NC_002695.1 similar to YBIB_ECOLI gi|1787019 (conserved in Escherichia coli K-12); glycosyl transferase family protein 960650 917616 ECs0878 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_308905.1 959688 D 386585 CDS NP_308906.1 15830133 917618 960791..961876 1 NC_002695.1 similar to YBIC_ECOLI gi|1787020 (conserved in Escherichia coli K-12); hypothetical protein 961876 917618 ECs0879 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308906.1 960791 D 386585 CDS NP_308907.1 15830134 917624 complement(962105..962365) 1 NC_002695.1 similar to YBIJ_ECOLI gi|1787021 (conserved in Escherichia coli K-12); hypothetical protein 962365 917624 ECs0880 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308907.1 962105 R 386585 CDS NP_308908.1 15830135 917620 complement(962630..962896) 1 NC_002695.1 similar to YBII_ECOLI gi|1787022 (conserved in Escherichia coli K-12); hypothetical protein 962896 917620 ECs0881 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308908.1 962630 R 386585 CDS NP_308909.2 38703894 917621 complement(962972..963658) 1 NC_002695.1 similar to YBIX_ECOLI gi|1787023 (conserved in Escherichia coli K-12); hydroxylase 963658 917621 ECs0882 Escherichia coli O157:H7 str. Sakai hydroxylase NP_308909.2 962972 R 386585 CDS NP_308910.1 15830137 917629 complement(963700..965982) 1 NC_002695.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 965982 917629 ECs0883 Escherichia coli O157:H7 str. Sakai catecholate siderophore receptor Fiu NP_308910.1 963700 R 386585 CDS NP_308911.1 15830138 917622 complement(966247..966651) 1 NC_002695.1 similar to YBIM_ECOLI gi|1787026 (conserved in Escherichia coli K-12); hypothetical protein 966651 917622 ECs0884 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308911.1 966247 R 386585 CDS NP_308912.1 15830139 917626 966702..967709 1 NC_002695.1 similar to YBIN_ECOLI gi|1787027 (conserved in Escherichia coli K-12); SAM-dependent methyltransferase 967709 917626 ECs0885 Escherichia coli O157:H7 str. Sakai SAM-dependent methyltransferase NP_308912.1 966702 D 386585 CDS NP_308913.1 15830140 917623 complement(967706..969931) 1 NC_002695.1 similar to YBIO_ECOLI gi|1787028 (conserved in Escherichia coli K-12); hypothetical protein 969931 917623 ECs0886 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308913.1 967706 R 386585 CDS NP_308914.1 15830141 917625 complement(970048..970770) 1 NC_002695.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 970770 glnQ 917625 glnQ Escherichia coli O157:H7 str. Sakai glutamine ABC transporter ATP-binding protein NP_308914.1 970048 R 386585 CDS NP_308915.1 15830142 917627 complement(970767..971426) 1 NC_002695.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 971426 glnP 917627 glnP Escherichia coli O157:H7 str. Sakai glutamine ABC transporter permease NP_308915.1 970767 R 386585 CDS NP_308916.1 15830143 917628 complement(971564..972310) 1 NC_002695.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 972310 glnH 917628 glnH Escherichia coli O157:H7 str. Sakai glutamine ABC transporter periplasmic protein NP_308916.1 971564 R 386585 CDS NP_308917.1 15830144 917630 complement(972714..973217) 1 NC_002695.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 973217 917630 ECs0890 Escherichia coli O157:H7 str. Sakai DNA starvation/stationary phase protection protein Dps NP_308917.1 972714 R 386585 CDS NP_308918.1 15830145 917633 complement(973516..974403) 1 NC_002695.1 similar to YBIF_ECOLI gi|1787033 (conserved in Escherichia coli K-12); threonine and homoserine efflux system 974403 917633 ECs0891 Escherichia coli O157:H7 str. Sakai threonine and homoserine efflux system NP_308918.1 973516 R 386585 CDS NP_308919.1 15830146 917632 974756..975271 1 NC_002695.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 975271 ompX 917632 ompX Escherichia coli O157:H7 str. Sakai outer membrane protein X NP_308919.1 974756 D 386585 CDS NP_308920.1 15830147 917631 complement(975320..976903) 1 NC_002695.1 similar to YBIP_ECOLI gi|1787035 (conserved in Escherichia coli K-12); hypothetical protein 976903 917631 ECs0893 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308920.1 975320 R 386585 CDS NP_308921.1 15830148 917636 977489..977956 1 NC_002695.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 977956 917636 ECs0894 Escherichia coli O157:H7 str. Sakai manganese transport regulator MntR NP_308921.1 977489 D 386585 CDS NP_308922.1 15830149 917639 977953..979071 1 NC_002695.1 similar to YBIR_ECOLI gi|1787039 (conserved in Escherichia coli K-12); hypothetical protein 979071 917639 ECs0895 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308922.1 977953 D 386585 CDS NP_308923.1 15830150 917644 complement(979129..980049) 1 NC_002695.1 similar to YBIS_ECOLI gi|1787040 (conserved in Escherichia coli K-12); hypothetical protein 980049 917644 ECs0896 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308923.1 979129 R 386585 CDS NP_308924.1 15830151 917637 980268..981860 1 NC_002695.1 similar to YBIT_ECOLI gi|1787041 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 981860 917637 ECs0897 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_308924.1 980268 D 386585 CDS NP_308925.1 15830152 917647 complement(982028..983293) 1 NC_002695.1 similar to YBIU_ECOLI gi|1787042 (conserved in Escherichia coli K-12); hypothetical protein 983293 917647 ECs0898 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308925.1 982028 R 386585 CDS NP_308926.1 15830153 917640 complement(983445..984260) 1 NC_002695.1 similar to B0822_ECOLI gi|1787043 (conserved in Escherichia coli K-12); hypothetical protein 984260 917640 ECs0899 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308926.1 983445 R 386585 CDS NP_308929.1 15830156 917645 complement(986843..987742) 1 NC_002695.1 similar to YBIY_ECOLI gi|1787045 (conserved in Escherichia coli K-12); pyruvate formate-lyase 2 activating enzyme 987742 917645 ECs0902 Escherichia coli O157:H7 str. Sakai pyruvate formate-lyase 2 activating enzyme NP_308929.1 986843 R 386585 CDS NP_308930.3 162139708 917642 987873..988535 1 NC_002695.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 988535 917642 ECs0903 Escherichia coli O157:H7 str. Sakai fructose-6-phosphate aldolase NP_308930.3 987873 D 386585 CDS NP_308931.1 15830158 917657 complement(988714..989463) 1 NC_002695.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 989463 917657 ECs0904 Escherichia coli O157:H7 str. Sakai molybdopterin biosynthesis protein MoeB NP_308931.1 988714 R 386585 CDS NP_308932.1 15830159 917643 complement(989463..990698) 1 NC_002695.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 990698 917643 ECs0905 Escherichia coli O157:H7 str. Sakai molybdopterin biosynthesis protein MoeA NP_308932.1 989463 R 386585 CDS NP_308935.1 15830162 917648 991887..993725 1 NC_002695.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 993725 917648 ECs0908 Escherichia coli O157:H7 str. Sakai glutathione transporter ATP-binding protein NP_308935.1 991887 D 386585 CDS NP_308936.1 15830163 917655 993745..995283 1 NC_002695.1 similar to B0830_ECOLI gi|1787052 (conserved in Escherichia coli K-12); transporter 995283 917655 ECs0909 Escherichia coli O157:H7 str. Sakai transporter NP_308936.1 993745 D 386585 CDS NP_308937.1 15830164 917654 995301..996221 1 NC_002695.1 similar to B0831_ECOLI gi|1787053 (conserved in Escherichia coli K-12); transport system permease 996221 917654 ECs0910 Escherichia coli O157:H7 str. Sakai transport system permease NP_308937.1 995301 D 386585 CDS NP_308938.1 15830165 917649 996224..997135 1 NC_002695.1 similar to B0832_ECOLI gi|1787054 (conserved in Escherichia coli K-12); transport system permease 997135 917649 ECs0911 Escherichia coli O157:H7 str. Sakai transport system permease NP_308938.1 996224 D 386585 CDS NP_308939.1 15830166 917651 997313..999661 1 NC_002695.1 similar to B0833_ECOLI gi|1787055 (conserved in Escherichia coli K-12); hypothetical protein 999661 917651 ECs0912 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308939.1 997313 D 386585 CDS NP_308940.1 15830167 917650 999669..1000997 1 NC_002695.1 similar to B0834_ECOLI gi|1787056 (conserved in Escherichia coli K-12); hypothetical protein 1000997 917650 ECs0913 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308940.1 999669 D 386585 CDS NP_308941.1 15830168 917653 1001038..1001532 1 NC_002695.1 hypothetical protein 1001532 917653 ECs0914 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308941.1 1001038 D 386585 CDS NP_944512.1 38703896 2693752 complement(1001067..1001396) 1 NC_002695.1 hypothetical protein 1001396 2693752 ECs5399 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944512.1 1001067 R 386585 CDS NP_944513.1 38703897 2693753 complement(1001386..1001772) 1 NC_002695.1 hypothetical protein 1001772 2693753 ECs5400 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944513.1 1001386 R 386585 CDS NP_308942.1 15830169 917659 complement(1001998..1003323) 1 NC_002695.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 1003323 rimO 917659 rimO Escherichia coli O157:H7 str. Sakai ribosomal protein S12 methylthiotransferase NP_308942.1 1001998 R 386585 CDS NP_308943.1 15830170 917658 1003536..1003919 1 NC_002695.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 1003919 bssR 917658 bssR Escherichia coli O157:H7 str. Sakai biofilm formation regulatory protein BssR NP_308943.1 1003536 D 386585 CDS NP_308944.1 15830171 917664 1004030..1005145 1 NC_002695.1 similar to YLII_ECOLI gi|1787060 (conserved in Escherichia coli K-12); dehydrogenase 1005145 917664 ECs0917 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_308944.1 1004030 D 386585 CDS NP_308945.2 38703898 917656 complement(1005142..1005768) 1 NC_002695.1 similar to YLIJ_ECOLI gi|1787061 (conserved in Escherichia coli K-12); transferase 1005768 917656 ECs0918 Escherichia coli O157:H7 str. Sakai transferase NP_308945.2 1005142 R 386585 CDS NP_308946.1 15830173 917665 1006014..1007216 1 NC_002695.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1007216 917665 ECs0919 Escherichia coli O157:H7 str. Sakai D-alanyl-D-alanine carboxypeptidase NP_308946.1 1006014 D 386585 CDS NP_308947.1 15830174 917661 complement(1007263..1008021) 1 NC_002695.1 similar to DEOR_ECOLI gi|1787063 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 1008021 917661 ECs0920 Escherichia coli O157:H7 str. Sakai DeoR family transcriptional regulator NP_308947.1 1007263 R 386585 CDS NP_308948.1 15830175 917663 complement(1008079..1008675) 1 NC_002695.1 similar to YBJG_ECOLI gi|1787064 (conserved in Escherichia coli K-12); undecaprenyl pyrophosphate phosphatase 1008675 917663 ECs0921 Escherichia coli O157:H7 str. Sakai undecaprenyl pyrophosphate phosphatase NP_308948.1 1008079 R 386585 CDS NP_308949.1 15830176 917662 1008960..1010192 1 NC_002695.1 similar to CMR_ECOLI gi|1787065 (conserved in Escherichia coli K-12); proton motive force efflux pump 1010192 917662 ECs0922 Escherichia coli O157:H7 str. Sakai proton motive force efflux pump NP_308949.1 1008960 D 386585 CDS NP_308950.1 15830177 917667 complement(1010233..1010517) 1 NC_002695.1 similar to YBJH_ECOLI gi|1787066 (conserved in Escherichia coli K-12); hypothetical protein 1010517 917667 ECs0923 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308950.1 1010233 R 386585 CDS NP_308951.2 38703899 917672 complement(1010603..1011418) 1 NC_002695.1 similar to B0844_ECOLI gi|1787067 (conserved in Escherichia coli K-12); hypothetical protein 1011418 917672 ECs0924 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308951.2 1010603 R 386585 CDS NP_308952.1 15830179 917671 complement(1011418..1012626) 1 NC_002695.1 similar to B0845_ECOLI gi|1787068 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 1012626 917671 ECs0925 Escherichia coli O157:H7 str. Sakai DeoR family transcriptional regulator NP_308952.1 1011418 R 386585 CDS NP_308953.1 15830180 917666 1012710..1013246 1 NC_002695.1 similar to B0846_ECOLI gi|1787069 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 1013246 917666 ECs0926 Escherichia coli O157:H7 str. Sakai DeoR family transcriptional regulator NP_308953.1 1012710 D 386585 CDS NP_308954.1 15830181 917673 complement(1013421..1015106) 1 NC_002695.1 similar to B0847_ECOLI gi|1787071 (conserved in Escherichia coli K-12); hypothetical protein 1015106 917673 ECs0927 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308954.1 1013421 R 386585 CDS NP_308955.1 15830182 917668 1015376..1015753 1 NC_002695.1 similar to YBJM_ECOLI gi|1787072 (conserved in Escherichia coli K-12); hypothetical protein 1015753 917668 ECs0928 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308955.1 1015376 D 386585 CDS NP_308956.1 15830183 917669 complement(1015783..1016040) 1 NC_002695.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1016040 grxA 917669 grxA Escherichia coli O157:H7 str. Sakai glutaredoxin NP_308956.1 1015783 R 386585 CDS NP_308957.1 15830184 917670 1016200..1016487 1 NC_002695.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 1016487 917670 ECs0930 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308957.1 1016200 D 386585 CDS NP_308958.1 15830185 917693 1016471..1017193 1 NC_002695.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 1017193 917693 ECs0931 Escherichia coli O157:H7 str. Sakai nitroreductase A NP_308958.1 1016471 D 386585 CDS NP_308959.1 15830186 917687 1017254..1018156 1 NC_002695.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 1018156 917687 ECs0932 Escherichia coli O157:H7 str. Sakai ribosomal protein S6 modification protein NP_308959.1 1017254 D 386585 CDS NP_308960.1 15830187 917677 1018244..1018720 1 NC_002695.1 similar to YBJN_ECOLI gi|1787077 (conserved in Escherichia coli K-12); sensory transduction regulator 1018720 917677 ECs0933 Escherichia coli O157:H7 str. Sakai sensory transduction regulator NP_308960.1 1018244 D 386585 CDS NP_308961.1 15830188 917675 1019071..1020183 1 NC_002695.1 similar to POTF_ECOLI gi|1787078 (conserved in Escherichia coli K-12); putrescine ABC transporter periplasmic-binding protein 1020183 917675 ECs0934 Escherichia coli O157:H7 str. Sakai putrescine ABC transporter periplasmic-binding protein NP_308961.1 1019071 D 386585 CDS NP_308962.1 15830189 917674 1020278..1021411 1 NC_002695.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding protein 1021411 potG 917674 potG Escherichia coli O157:H7 str. Sakai putrescine transporter ATP-binding protein NP_308962.1 1020278 D 386585 CDS NP_308963.1 15830190 917676 1021421..1022374 1 NC_002695.1 similar to POTH_ECOLI gi|1787080 (conserved in Escherichia coli K-12); putrescine ABC transporter membrane protein 1022374 917676 ECs0936 Escherichia coli O157:H7 str. Sakai putrescine ABC transporter membrane protein NP_308963.1 1021421 D 386585 CDS NP_308964.1 15830191 917680 1022371..1023216 1 NC_002695.1 similar to POTI_ECOLI gi|1787081 (conserved in Escherichia coli K-12); putrescine ABC transporter membrane protein 1023216 917680 ECs0937 Escherichia coli O157:H7 str. Sakai putrescine ABC transporter membrane protein NP_308964.1 1022371 D 386585 CDS NP_308965.1 15830192 917683 1023276..1023764 1 NC_002695.1 similar to YBJO_ECOLI gi|1787082 (conserved in Escherichia coli K-12); hypothetical protein 1023764 917683 ECs0938 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308965.1 1023276 D 386585 CDS NP_308966.1 15830193 917679 1023805..1024932 1 NC_002695.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1024932 rumB 917679 rumB Escherichia coli O157:H7 str. Sakai 23S rRNA methyluridine methyltransferase NP_308966.1 1023805 D 386585 CDS NP_308967.1 15830194 917678 1025212..1026555 1 NC_002695.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1026555 ulaA 917678 ulaA Escherichia coli O157:H7 str. Sakai PTS system ascorbate-specific transporter subunit IIC NP_308967.1 1025212 D 386585 CDS NP_308968.1 15830195 917681 1026577..1026897 1 NC_002695.1 similar to phosphotransferase system enzymes IIB e.g. [Escherichia coli] gi|732028|sp|P39302|PTXB_ECOLI; PTS system enzyme IIB 1026897 917681 ECs0941 Escherichia coli O157:H7 str. Sakai PTS system enzyme IIB NP_308968.1 1026577 D 386585 CDS NP_308969.1 15830196 917684 1026909..1028390 1 NC_002695.1 hypothetical protein 1028390 917684 ECs0942 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308969.1 1026909 D 386585 CDS NP_308970.1 15830197 917682 complement(1028441..1029172) 1 NC_002695.1 similar to ARTJ_ECOLI gi|1787085 (conserved in Escherichia coli K-12); arginine ABC transporter substrate-binding protein 1029172 917682 ECs0943 Escherichia coli O157:H7 str. Sakai arginine ABC transporter substrate-binding protein NP_308970.1 1028441 R 386585 CDS NP_308971.1 15830198 917725 complement(1029463..1030131) 1 NC_002695.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease ArtM 1030131 artM 917725 artM Escherichia coli O157:H7 str. Sakai arginine transporter permease ArtM NP_308971.1 1029463 R 386585 CDS NP_308972.1 15830199 917685 complement(1030131..1030847) 1 NC_002695.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease ArtQ 1030847 917685 ECs0945 Escherichia coli O157:H7 str. Sakai arginine transporter permease ArtQ NP_308972.1 1030131 R 386585 CDS NP_308973.1 15830200 917686 complement(1030854..1031585) 1 NC_002695.1 similar to ARTI_ECOLI gi|1787088 (conserved in Escherichia coli K-12); arginine ABC transporter substrate-binding protein 1031585 917686 ECs0946 Escherichia coli O157:H7 str. Sakai arginine ABC transporter substrate-binding protein NP_308973.1 1030854 R 386585 CDS NP_308974.1 15830201 917689 complement(1031603..1032331) 1 NC_002695.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding protein 1032331 artP 917689 artP Escherichia coli O157:H7 str. Sakai arginine transporter ATP-binding protein NP_308974.1 1031603 R 386585 CDS NP_308975.1 15830202 917688 complement(1032549..1033064) 1 NC_002695.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 1033064 917688 ECs0948 Escherichia coli O157:H7 str. Sakai lipoprotein NP_308975.1 1032549 R 386585 CDS NP_308978.1 15830205 917690 complement(1035462..1035650) 1 NC_002695.1 hypothetical protein 1035650 917690 ECs0951 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308978.1 1035462 R 386585 CDS NP_308979.1 15830206 917708 1035705..1036028 1 NC_002695.1 similar to B0866_ECOLI gi|1787091 (conserved in Escherichia coli K-12); hypothetical protein 1036028 917708 ECs0952 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308979.1 1035705 D 386585 CDS NP_308980.1 15830207 917694 1036025..1036855 1 NC_002695.1 similar to B0867_ECOLI gi|1787092 (conserved in Escherichia coli K-12); regulator 1036855 917694 ECs0953 Escherichia coli O157:H7 str. Sakai regulator NP_308980.1 1036025 D 386585 CDS NP_308981.1 15830208 917696 complement(1036852..1037901) 1 NC_002695.1 similar to B0868_ECOLI gi|1787093 (conserved in Escherichia coli K-12); nucleotide di-P-sugar epimerase or dehydratase 1037901 917696 ECs0954 Escherichia coli O157:H7 str. Sakai nucleotide di-P-sugar epimerase or dehydratase NP_308981.1 1036852 R 386585 CDS NP_308982.1 15830209 917697 complement(1037964..1039394) 1 NC_002695.1 similar to YBJT_ECOLI gi|1787094 (conserved in Escherichia coli K-12); dTDP-glucose enzyme 1039394 917697 ECs0955 Escherichia coli O157:H7 str. Sakai dTDP-glucose enzyme NP_308982.1 1037964 R 386585 CDS NP_308983.1 15830210 917698 complement(1039405..1040406) 1 NC_002695.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 1040406 917698 ECs0956 Escherichia coli O157:H7 str. Sakai L-threonine aldolase NP_308983.1 1039405 R 386585 CDS NP_308984.1 15830211 917701 complement(1040443..1042161) 1 NC_002695.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 1042161 917701 ECs0957 Escherichia coli O157:H7 str. Sakai pyruvate dehydrogenase NP_308984.1 1040443 R 386585 CDS NP_308985.1 15830212 917695 complement(1042294..1043262) 1 NC_002695.1 similar to HCR_ECOLI gi|7387728 (conserved in Escherichia coli K-12); HCP oxidoreductase 1043262 917695 ECs0958 Escherichia coli O157:H7 str. Sakai HCP oxidoreductase NP_308985.1 1042294 R 386585 CDS NP_308986.2 38703900 917700 complement(1043274..1044926) 1 NC_002695.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 1044926 917700 ECs0959 Escherichia coli O157:H7 str. Sakai hydroxylamine reductase NP_308986.2 1043274 R 386585 CDS NP_308987.1 15830214 917705 complement(1045070..1045969) 1 NC_002695.1 similar to surface protein YBJE_ECOLI gi|1787100 (conserved in Escherichia coli K-12); surface protein 1045969 917705 ECs0960 Escherichia coli O157:H7 str. Sakai surface protein NP_308987.1 1045070 R 386585 CDS NP_308988.1 15830215 917703 complement(1046427..1047122) 1 NC_002695.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 1047122 917703 ECs0961 Escherichia coli O157:H7 str. Sakai aquaporin Z NP_308988.1 1046427 R 386585 CDS NP_308989.1 15830216 917699 1047548..1049206 1 NC_002695.1 similar to YBJD_ECOLI gi|1787102 (conserved in Escherichia coli K-12); hypothetical protein 1049206 917699 ECs0962 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308989.1 1047548 D 386585 CDS NP_308990.1 15830217 917707 complement(1049203..1050195) 1 NC_002695.1 similar to YBJX_ECOLI gi|1787103 (conserved in Escherichia coli K-12); hypothetical protein 1050195 917707 ECs0963 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_308990.1 1049203 R 386585 CDS NP_308991.2 38703901 917702 1050310..1051425 1 NC_002695.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 1051425 917702 ECs0964 Escherichia coli O157:H7 str. Sakai macrolide transporter subunit MacA NP_308991.2 1050310 D 386585 CDS NP_308992.1 15830219 917704 1051422..1053368 1 NC_002695.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 1053368 917704 ECs0965 Escherichia coli O157:H7 str. Sakai macrolide transporter ATP-binding /permease NP_308992.1 1051422 D 386585 CDS NP_308993.1 15830220 917710 complement(1053441..1053665) 1 NC_002695.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 1053665 917710 ECs0966 Escherichia coli O157:H7 str. Sakai stationary phase/starvation inducible regulatory protein CspD NP_308993.1 1053441 R 386585 CDS NP_308994.1 15830221 917706 1053988..1054308 1 NC_002695.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1054308 clpS 917706 clpS Escherichia coli O157:H7 str. Sakai ATP-dependent Clp protease adaptor protein ClpS NP_308994.1 1053988 D 386585 CDS NP_308995.1 15830222 917711 1054339..1056615 1 NC_002695.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding protein 1056615 clpA 917711 clpA Escherichia coli O157:H7 str. Sakai ATP-dependent Clp protease ATP-binding protein NP_308995.1 1054339 D 386585 CDS NP_308996.1 15830223 917713 complement(1057302..1057520) 1 NC_002695.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1057520 infA 917713 infA Escherichia coli O157:H7 str. Sakai translation initiation factor IF-1 NP_308996.1 1057302 R 386585 CDS NP_308997.1 15830224 917712 complement(1057805..1058509) 1 NC_002695.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 1058509 aat 917712 aat Escherichia coli O157:H7 str. Sakai leucyl/phenylalanyl-tRNA--protein transferase NP_308997.1 1057805 R 386585 CDS NP_308998.1 15830225 917716 complement(1058551..1060272) 1 NC_002695.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1060272 917716 ECs0971 Escherichia coli O157:H7 str. Sakai cysteine/glutathione ABC transporter membrane/ATP-binding protein NP_308998.1 1058551 R 386585 CDS NP_308999.1 15830226 917714 complement(1060273..1062039) 1 NC_002695.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1062039 917714 ECs0972 Escherichia coli O157:H7 str. Sakai cysteine/glutathione ABC transporter membrane/ATP-binding protein NP_308999.1 1060273 R 386585 CDS NP_309000.1 15830227 917715 complement(1062162..1063127) 1 NC_002695.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 1063127 917715 ECs0973 Escherichia coli O157:H7 str. Sakai thioredoxin reductase NP_309000.1 1062162 R 386585 CDS NP_309001.1 15830228 917724 1063672..1064166 1 NC_002695.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1064166 917724 ECs0974 Escherichia coli O157:H7 str. Sakai leucine-responsive transcriptional regulator NP_309001.1 1063672 D 386585 CDS NP_309002.1 15830229 917727 1064301..1068329 1 NC_002695.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 1068329 917727 ECs0975 Escherichia coli O157:H7 str. Sakai DNA translocase FtsK NP_309002.1 1064301 D 386585 CDS NP_309003.1 15830230 917717 1068481..1069095 1 NC_002695.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1069095 lolA 917717 lolA Escherichia coli O157:H7 str. Sakai outer-membrane lipoprotein carrier protein NP_309003.1 1068481 D 386585 CDS NP_309004.1 15830231 917730 1069106..1070449 1 NC_002695.1 similar to YCAJ_ECOLI gi|1787119 (conserved in Escherichia coli K-12); recombination factor protein RarA 1070449 917730 ECs0977 Escherichia coli O157:H7 str. Sakai recombination factor protein RarA NP_309004.1 1069106 D 386585 CDS NP_309005.1 15830232 917719 1070540..1071832 1 NC_002695.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1071832 917719 ECs0978 Escherichia coli O157:H7 str. Sakai seryl-tRNA synthetase NP_309005.1 1070540 D 386585 CDS NP_309006.2 38703902 917718 1072071..1074515 1 NC_002695.1 similar to DMSA_ECOLI gi|1787121 (conserved in Escherichia coli K-12); anaerobic dimethyl sulfoxide reductase subunit A 1074515 917718 ECs0979 Escherichia coli O157:H7 str. Sakai anaerobic dimethyl sulfoxide reductase subunit A NP_309006.2 1072071 D 386585 CDS NP_309007.1 15830234 917721 1074526..1075143 1 NC_002695.1 similar to DMSB_ECOLI gi|1787122 (conserved in Escherichia coli K-12); anaerobic dimethyl sulfoxide reductase subunit B 1075143 917721 ECs0980 Escherichia coli O157:H7 str. Sakai anaerobic dimethyl sulfoxide reductase subunit B NP_309007.1 1074526 D 386585 CDS NP_309008.1 15830235 917729 1075145..1076008 1 NC_002695.1 similar to DMSC_ECOLI gi|1787123 (conserved in Escherichia coli K-12); anaerobic dimethyl sulfoxide reductase subunit C 1076008 917729 ECs0981 Escherichia coli O157:H7 str. Sakai anaerobic dimethyl sulfoxide reductase subunit C NP_309008.1 1075145 D 386585 CDS NP_309009.1 15830236 917720 complement(1076044..1076670) 1 NC_002695.1 similar to YCAC_ECOLI gi|1787124 (conserved in Escherichia coli K-12); hypothetical protein 1076670 917720 ECs0982 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309009.1 1076044 R 386585 CDS NP_309010.1 15830237 917726 1076985..1078133 1 NC_002695.1 similar to YCAD_ECOLI gi|1787126 (conserved in Escherichia coli K-12); MFS family transporter protein 1078133 917726 ECs0983 Escherichia coli O157:H7 str. Sakai MFS family transporter protein NP_309010.1 1076985 D 386585 CDS NP_309011.1 15830238 917722 1078151..1079773 1 NC_002695.1 similar to B0899_ECOLI gi|1787127 (conserved in Escherichia coli K-12); transport 1079773 917722 ECs0984 Escherichia coli O157:H7 str. Sakai transport NP_309011.1 1078151 D 386585 CDS NP_309012.1 15830239 917728 complement(1079983..1080723) 1 NC_002695.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 1080723 pflA 917728 pflA Escherichia coli O157:H7 str. Sakai pyruvate formate lyase-activating enzyme 1 NP_309012.1 1079983 R 386585 CDS NP_309013.1 15830240 917731 complement(1080915..1083197) 1 NC_002695.1 similar to PFLB_ECOLI gi|1787131 (conserved in Escherichia coli K-12); formate acetyltransferase 1 1083197 917731 ECs0986 Escherichia coli O157:H7 str. Sakai formate acetyltransferase 1 NP_309013.1 1080915 R 386585 CDS NP_309014.1 15830241 917772 complement(1083252..1084109) 1 NC_002695.1 similar to FOCA_ECOLI gi|1787132 (conserved in Escherichia coli K-12); formate transporter 1084109 917772 ECs0987 Escherichia coli O157:H7 str. Sakai formate transporter NP_309014.1 1083252 R 386585 CDS NP_309015.2 38703903 917732 complement(1084515..1086275) 1 NC_002695.1 similar to YCAO_ECOLI gi|1787133 (conserved in Escherichia coli K-12); hypothetical protein 1086275 917732 ECs0988 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309015.2 1084515 R 386585 CDS NP_309016.1 15830243 917738 1086405..1087097 1 NC_002695.1 similar to YCAP_ECOLI gi|1787135 (conserved in Escherichia coli K-12); hypothetical protein 1087097 917738 ECs0989 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309016.1 1086405 D 386585 CDS NP_309017.1 15830244 917733 1087296..1088384 1 NC_002695.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1088384 917733 ECs0990 Escherichia coli O157:H7 str. Sakai phosphoserine aminotransferase NP_309017.1 1087296 D 386585 CDS NP_309018.1 15830245 917735 1088455..1089738 1 NC_002695.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1089738 917735 ECs0991 Escherichia coli O157:H7 str. Sakai 3-phosphoshikimate 1-carboxyvinyltransferase NP_309018.1 1088455 D 386585 CDS NP_309019.1 15830246 917737 1089883..1090671 1 NC_002695.1 similar to YCAL_ECOLI gi|1787138 (conserved in Escherichia coli K-12); heat shock protein 1090671 917737 ECs0992 Escherichia coli O157:H7 str. Sakai heat shock protein NP_309019.1 1089883 D 386585 CDS NP_309020.1 15830247 917734 1090844..1091527 1 NC_002695.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1091527 cmk 917734 cmk Escherichia coli O157:H7 str. Sakai cytidylate kinase NP_309020.1 1090844 D 386585 CDS NP_309021.1 15830248 917736 1091638..1093311 1 NC_002695.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1093311 rpsA 917736 rpsA Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S1 NP_309021.1 1091638 D 386585 CDS NP_309022.1 15830249 917740 1093471..1093755 1 NC_002695.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1093755 ihfB 917740 ihfB Escherichia coli O157:H7 str. Sakai integration host factor subunit beta NP_309022.1 1093471 D 386585 CDS NP_309023.2 38703904 917743 1093962..1096226 1 NC_002695.1 similar to YCAI_ECOLI gi|1787142 (conserved in Escherichia coli K-12); hypothetical protein 1096226 917743 ECs0996 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309023.2 1093962 D 386585 CDS NP_309024.1 15830251 917742 1096263..1098011 1 NC_002695.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 1098011 917742 ECs0997 Escherichia coli O157:H7 str. Sakai lipid transporter ATP-binding protein/permease NP_309024.1 1096263 D 386585 CDS NP_309025.1 15830252 917752 1098008..1098994 1 NC_002695.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1098994 lpxK 917752 lpxK Escherichia coli O157:H7 str. Sakai tetraacyldisaccharide 4'-kinase NP_309025.1 1098008 D 386585 CDS NP_309026.1 15830253 917741 1099031..1100263 1 NC_002695.1 similar to YCAQ_ECOLI gi|1787145 (conserved in Escherichia coli K-12); hypothetical protein 1100263 917741 ECs0999 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309026.1 1099031 D 386585 CDS NP_309027.1 15830254 917739 1100315..1100497 1 NC_002695.1 similar to YCAR_ECOLI gi|1787146 (conserved in Escherichia coli K-12); hypothetical protein 1100497 917739 ECs1000 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309027.1 1100315 D 386585 CDS NP_309028.1 15830255 917744 1100494..1101240 1 NC_002695.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1101240 917744 ECs1001 Escherichia coli O157:H7 str. Sakai 3-deoxy-manno-octulosonate cytidylyltransferase NP_309028.1 1100494 D 386585 CDS NP_309029.1 15830256 917745 1101394..1102287 1 NC_002695.1 similar to B0919_ECOLI gi|1787149 (conserved in Escherichia coli K-12); hypothetical protein 1102287 917745 ECs1002 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309029.1 1101394 D 386585 CDS NP_309030.1 15830257 917746 complement(1102264..1103043) 1 NC_002695.1 similar to YCBC_ECOLI gi|1787150 (conserved in Escherichia coli K-12); hypothetical protein 1103043 917746 ECs1003 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309030.1 1102264 R 386585 CDS NP_309031.1 15830258 917747 1103179..1103964 1 NC_002695.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1103964 917747 ECs1004 Escherichia coli O157:H7 str. Sakai metallothionein SmtA NP_309031.1 1103179 D 386585 CDS NP_309032.1 15830259 917748 1103961..1105283 1 NC_002695.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1105283 917748 ECs1005 Escherichia coli O157:H7 str. Sakai condesin subunit F NP_309032.1 1103961 D 386585 CDS NP_309033.1 15830260 917749 1105264..1105968 1 NC_002695.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1105968 917749 ECs1006 Escherichia coli O157:H7 str. Sakai condesin subunit E NP_309033.1 1105264 D 386585 CDS NP_309034.1 15830261 917753 1105968..1110428 1 NC_002695.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1110428 mukB 917753 mukB Escherichia coli O157:H7 str. Sakai cell division protein MukB NP_309034.1 1105968 D 386585 CDS NP_309035.1 15830262 917750 1110689..1112536 1 NC_002695.1 similar to YCBB_ECOLI gi|1787155 (conserved in Escherichia coli K-12); hypothetical protein 1112536 917750 ECs1008 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309035.1 1110689 D 386585 CDS NP_309036.1 15830263 917754 1112717..1113265 1 NC_002695.1 similar to YCBK_ECOLI gi|1787157 (conserved in Escherichia coli K-12); hypothetical protein 1113265 917754 ECs1009 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309036.1 1112717 D 386585 CDS NP_309037.1 15830264 917751 1113292..1113939 1 NC_002695.1 similar to YCBL_ECOLI gi|1787158 (conserved in Escherichia coli K-12); hypothetical protein 1113939 917751 ECs1010 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309037.1 1113292 D 386585 CDS NP_309038.1 15830265 917755 complement(1113990..1115180) 1 NC_002695.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1115180 917755 ECs1011 Escherichia coli O157:H7 str. Sakai aromatic amino acid aminotransferase NP_309038.1 1113990 R 386585 CDS NP_309039.1 15830266 917757 complement(1115365..1116453) 1 NC_002695.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 1116453 917757 ECs1012 Escherichia coli O157:H7 str. Sakai outer membrane protein F NP_309039.1 1115365 R 386585 CDS NP_309040.1 15830267 917756 complement(1117056..1118456) 1 NC_002695.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1118456 asnC 917756 asnC Escherichia coli O157:H7 str. Sakai asparaginyl-tRNA synthetase NP_309040.1 1117056 R 386585 CDS NP_309041.1 15830268 917759 complement(1118625..1119827) 1 NC_002695.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1119827 917759 ECs1014 Escherichia coli O157:H7 str. Sakai nicotinate phosphoribosyltransferase NP_309041.1 1118625 R 386585 CDS NP_309042.1 15830269 917763 1120093..1122705 1 NC_002695.1 similar to PEPN_ECOLI gi|1787163 (conserved in Escherichia coli K-12); aminopeptidase 1122705 pepN 917763 pepN Escherichia coli O157:H7 str. Sakai aminopeptidase NP_309042.1 1120093 D 386585 CDS NP_309043.1 15830270 917760 complement(1122748..1123515) 1 NC_002695.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding protein and SsuC the permease; aliphatic sulfonates transport ATP-binding protein 1123515 ssuB 917760 ssuB Escherichia coli O157:H7 str. Sakai aliphatic sulfonates transport ATP-binding protein NP_309043.1 1122748 R 386585 CDS NP_309044.1 15830271 917758 complement(1123512..1124303) 1 NC_002695.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding protein and SsuC the permease; alkanesulfonate transporter permease 1124303 ssuC 917758 ssuC Escherichia coli O157:H7 str. Sakai alkanesulfonate transporter permease NP_309044.1 1123512 R 386585 CDS NP_309045.1 15830272 917762 complement(1124315..1125460) 1 NC_002695.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 1125460 917762 ECs1018 Escherichia coli O157:H7 str. Sakai alkanesulfonate monooxygenase NP_309045.1 1124315 R 386585 CDS NP_309046.1 15830273 917766 complement(1125457..1126416) 1 NC_002695.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding protein and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1126416 917766 ECs1019 Escherichia coli O157:H7 str. Sakai alkanesulfonate transporter substrate-binding subunit NP_309046.1 1125457 R 386585 CDS NP_309047.1 15830274 917761 complement(1126409..1126984) 1 NC_002695.1 similar to SSUE_ECOLI gi|2507138 (conserved in Escherichia coli K-12); NAD(P)H-dependent FMN reductase 1126984 917761 ECs1020 Escherichia coli O157:H7 str. Sakai NAD(P)H-dependent FMN reductase NP_309047.1 1126409 R 386585 CDS NP_309048.1 15830275 917768 1127331..1127879 1 NC_002695.1 similar to YCBQ_ECOLI gi|1787170 (conserved in Escherichia coli K-12); fimbrial-like protein 1127879 917768 ECs1021 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_309048.1 1127331 D 386585 CDS NP_309049.1 15830276 917764 1127962..1128663 1 NC_002695.1 similar to YCBR_ECOLI gi|1787171 (conserved in Escherichia coli K-12); chaperone 1128663 917764 ECs1022 Escherichia coli O157:H7 str. Sakai chaperone NP_309049.1 1127962 D 386585 CDS NP_309052.1 15830279 917767 1131278..1132258 1 NC_002695.1 similar to Salmonella FimH protein and B0941_ECOLI gi|1787173 (conserved in Escherichia coli K-12); FimH-like protein 1132258 917767 ECs1025 Escherichia coli O157:H7 str. Sakai FimH-like protein NP_309052.1 1131278 D 386585 CDS NP_309053.1 15830280 917770 1132706..1132903 1 NC_002695.1 similar to fimbrial-like protein B0942_ECOLI gi|1787174; hypothetical protein 1132903 917770 ECs1026 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309053.1 1132706 D 386585 CDS NP_309054.1 15830281 917778 1132863..1133426 1 NC_002695.1 similar to B0943_ECOLI gi|1787175 (conserved in Escherichia coli K-12); fimbrial-like protein 1133426 917778 ECs1027 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_309054.1 1132863 D 386585 CDS NP_309055.1 15830282 917769 1133392..1133961 1 NC_002695.1 similar to chaperone YCBF_ECOLI gi|1787176; hypothetical protein 1133961 917769 ECs1028 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309055.1 1133392 D 386585 CDS NP_309056.1 15830283 917771 1134239..1135249 1 NC_002695.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1135249 917771 ECs1029 Escherichia coli O157:H7 str. Sakai dihydroorotate dehydrogenase 2 NP_309056.1 1134239 D 386585 CDS NP_309057.2 38703905 917775 1135423..1135965 1 NC_002695.1 similar to YCBW_ECOLI gi|1787178 (conserved in Escherichia coli K-12); hypothetical protein 1135965 917775 ECs1030 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309057.2 1135423 D 386585 CDS NP_309058.1 15830285 917774 complement(1135962..1137071) 1 NC_002695.1 similar to B0947_ECOLI gi|1787179 (conserved in Escherichia coli K-12); hypothetical protein 1137071 917774 ECs1031 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309058.1 1135962 R 386585 CDS NP_309059.1 15830286 917780 1137315..1139423 1 NC_002695.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1139423 rlmL 917780 rlmL Escherichia coli O157:H7 str. Sakai 23S rRNA m(2)G2445 methyltransferase NP_309059.1 1137315 D 386585 CDS NP_309060.1 15830287 917781 1139435..1141342 1 NC_002695.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1141342 917781 ECs1033 Escherichia coli O157:H7 str. Sakai ABC transporter ATPase NP_309060.1 1139435 D 386585 CDS NP_309061.1 15830288 917777 1141472..1142725 1 NC_002695.1 similar to PQIA_ECOLI gi|1787183 (conserved in Escherichia coli K-12); paraquat-inducible protein A 1142725 917777 ECs1034 Escherichia coli O157:H7 str. Sakai paraquat-inducible protein A NP_309061.1 1141472 D 386585 CDS NP_309062.1 15830289 917128 1142730..1144370 1 NC_002695.1 similar to PQIB_ECOLI gi|1787184 (conserved in Escherichia coli K-12); paraquat-inducible protein B 1144370 917128 ECs1035 Escherichia coli O157:H7 str. Sakai paraquat-inducible protein B NP_309062.1 1142730 D 386585 CDS NP_309063.1 15830290 917129 1144382..1144930 1 NC_002695.1 similar to YMBA_ECOLI gi|1787185 (conserved in Escherichia coli K-12); hypothetical protein 1144930 917129 ECs1036 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309063.1 1144382 D 386585 CDS NP_309064.1 15830291 913590 1145186..1145353 1 NC_002695.1 similar to RMF_ECOLI gi|1787186 (conserved in Escherichia coli K-12); ribosome modulation factor 1145353 913590 ECs1037 Escherichia coli O157:H7 str. Sakai ribosome modulation factor NP_309064.1 1145186 D 386585 CDS NP_309065.1 15830292 917125 complement(1145423..1145941) 1 NC_002695.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1145941 917125 ECs1038 Escherichia coli O157:H7 str. Sakai 3-hydroxydecanoyl-ACP dehydratase NP_309065.1 1145423 R 386585 CDS NP_309066.1 15830293 917130 complement(1146010..1147770) 1 NC_002695.1 similar to B0955_ECOLI gi|1787188 (conserved in Escherichia coli K-12); ATP-dependent protease 1147770 917130 ECs1039 Escherichia coli O157:H7 str. Sakai ATP-dependent protease NP_309066.1 1146010 R 386585 CDS NP_309067.1 15830294 916914 1147956..1148408 1 NC_002695.1 similar to YCBG_ECOLI gi|1787190 (conserved in Escherichia coli K-12); hypothetical protein 1148408 916914 ECs1040 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309067.1 1147956 D 386585 CDS NP_309068.1 15830295 917123 complement(1148484..1149524) 1 NC_002695.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1149524 917123 ECs1041 Escherichia coli O157:H7 str. Sakai outer membrane protein A NP_309068.1 1148484 R 386585 CDS NP_309069.1 15830296 916918 complement(1149881..1150390) 1 NC_002695.1 similar to SULA_ECOLI gi|1787192 (conserved in Escherichia coli K-12); SOS cell division inhibitor 1150390 916918 ECs1042 Escherichia coli O157:H7 str. Sakai SOS cell division inhibitor NP_309069.1 1149881 R 386585 CDS NP_309070.1 15830297 914173 1150609..1151238 1 NC_002695.1 similar to B0959_ECOLI gi|1787193 (conserved in Escherichia coli K-12); hypothetical protein 1151238 914173 ECs1043 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309070.1 1150609 D 386585 CDS NP_309071.1 15830298 917114 complement(1151201..1153363) 1 NC_002695.1 similar to B0960_ECOLI gi|1787194 (conserved in Escherichia coli K-12); hypothetical protein 1153363 917114 ECs1044 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309071.1 1151201 R 386585 CDS NP_309072.1 15830299 912728 complement(1153373..1153819) 1 NC_002695.1 similar to YCCF_ECOLI gi|1787195 (conserved in Escherichia coli K-12); hypothetical protein 1153819 912728 ECs1045 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309072.1 1153373 R 386585 CDS NP_309073.1 15830300 913997 1153942..1155996 1 NC_002695.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1155996 helD 913997 helD Escherichia coli O157:H7 str. Sakai DNA helicase IV NP_309073.1 1153942 D 386585 CDS NP_309074.2 162139803 915175 complement(1156028..1156486) 1 NC_002695.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1156486 mgsA 915175 mgsA Escherichia coli O157:H7 str. Sakai methylglyoxal synthase NP_309074.2 1156028 R 386585 CDS NP_309075.1 15830302 912544 complement(1156582..1157244) 1 NC_002695.1 similar to B0964_ECOLI gi|1787198 (conserved in Escherichia coli K-12); hypothetical protein 1157244 912544 ECs1048 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309075.1 1156582 R 386585 CDS NP_309076.1 15830303 913587 1157417..1157830 1 NC_002695.1 similar to B0965_ECOLI gi|1787199 (conserved in Escherichia coli K-12); hypothetical protein 1157830 913587 ECs1049 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309076.1 1157417 D 386585 CDS NP_309077.2 38703906 916125 complement(1157875..1158192) 1 NC_002695.1 similar to YCCV_ECOLI gi|1787200 (conserved in Escherichia coli K-12); heat shock protein HspQ 1158192 916125 ECs1050 Escherichia coli O157:H7 str. Sakai heat shock protein HspQ NP_309077.2 1157875 R 386585 CDS NP_309078.2 38703907 916915 complement(1158250..1159440) 1 NC_002695.1 similar to B0967_ECOLI gi|1787201 (conserved in Escherichia coli K-12); oxidoreductase 1159440 916915 ECs1051 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_309078.2 1158250 R 386585 CDS NP_309079.1 15830306 916920 1159535..1159813 1 NC_002695.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1159813 916920 ECs1052 Escherichia coli O157:H7 str. Sakai acylphosphatase NP_309079.1 1159535 D 386585 CDS NP_309080.2 38703908 912999 complement(1159810..1160139) 1 NC_002695.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1160139 912999 ECs1053 Escherichia coli O157:H7 str. Sakai sulfur transfer protein TusE NP_309080.2 1159810 R 386585 CDS NP_309081.1 15830308 912790 complement(1160230..1160889) 1 NC_002695.1 similar to YCCA_ECOLI gi|1787205 (conserved in Escherichia coli K-12); hypothetical protein 1160889 912790 ECs1054 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309081.1 1160230 R 386585 CDS NP_309082.1 15830309 912606 complement(1161297..1162316) 1 NC_002695.1 similar to integrase [Bacteriophage HK022] gi|138560|sp|P16407|VINT_BPHK0; integrase 1162316 912606 ECs1055 Escherichia coli O157:H7 str. Sakai integrase NP_309082.1 1161297 R 386585 CDS NP_309084.1 15830311 912439 complement(1162604..1165075) 1 NC_002695.1 hypothetical protein 1165075 912439 ECs1057 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309084.1 1162604 R 386585 CDS NP_309085.1 15830312 912451 complement(1165169..1165360) 1 NC_002695.1 similar to YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein 1165360 912451 ECs1058 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309085.1 1165169 R 386585 CDS NP_309086.1 15830313 914198 complement(1165357..1165545) 1 NC_002695.1 similar to dicB [Escherichia coli] gi|2507009|sp|P09557|DICB_ECOLI; cell division inhibition protein 1165545 914198 ECs1059 Escherichia coli O157:H7 str. Sakai cell division inhibition protein NP_309086.1 1165357 R 386585 CDS NP_309087.1 15830314 912657 1165812..1166117 1 NC_002695.1 hypothetical protein 1166117 912657 ECs1060 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309087.1 1165812 D 386585 CDS NP_309088.1 15830315 912568 1166119..1166304 1 NC_002695.1 hypothetical protein 1166304 912568 ECs1061 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309088.1 1166119 D 386585 CDS NP_309090.1 15830317 912441 complement(1166491..1166880) 1 NC_002695.1 hypothetical protein 1166880 912441 ECs1063 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309090.1 1166491 R 386585 CDS NP_309092.1 15830319 912966 complement(1167022..1167177) 1 NC_002695.1 similar to YdfA [Escherichia coli] gi|140584|sp|P29008|YDFA_ECOLI; hypothetical protein 1167177 912966 ECs1065 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309092.1 1167022 R 386585 CDS NP_309094.1 15830321 914057 complement(1167455..1167742) 1 NC_002695.1 similar to yacB [Plasmid ColIb-P9] gi|4512441|dbj|BAA75090.1; hypothetical protein 1167742 914057 ECs1067 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309094.1 1167455 R 386585 CDS NP_309095.1 15830322 912767 complement(1167742..1167933) 1 NC_002695.1 hypothetical protein 1167933 912767 ECs1068 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309095.1 1167742 R 386585 CDS NP_309096.2 38703909 912951 complement(1167961..1168362) 1 NC_002695.1 similar to probable regulatory protein [Salmonella typhimurium] gi|7467281|pir||T03008; similar toDicA [Escherichia coli] gi|118631|sp|P06966|DICA_ECOLI; regulatory protein 1168362 912951 ECs1069 Escherichia coli O157:H7 str. Sakai regulatory protein NP_309096.2 1167961 R 386585 CDS NP_309097.1 15830324 912969 1168471..1168743 1 NC_002695.1 hypothetical protein 1168743 912969 ECs1070 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309097.1 1168471 D 386585 CDS NP_309098.1 15830325 913545 1168727..1169152 1 NC_002695.1 similar to YdaT [Escherichia coli] gi|3025103|sp|P76064|YDAT_ECOLI; hypothetical protein 1169152 913545 ECs1071 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309098.1 1168727 D 386585 CDS NP_309099.1 15830326 912987 complement(1169359..1169814) 1 NC_002695.1 hypothetical protein 1169814 912987 ECs1072 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309099.1 1169359 R 386585 CDS NP_309100.1 15830327 913538 1169893..1170984 1 NC_002695.1 hypothetical protein 1170984 913538 ECs1073 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309100.1 1169893 D 386585 CDS NP_309101.1 15830328 912950 1170991..1171737 1 NC_002695.1 acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 1171737 912950 ECs1074 Escherichia coli O157:H7 str. Sakai replication protein NP_309101.1 1170991 D 386585 CDS NP_309102.1 15830329 912847 1171759..1172529 1 NC_002695.1 similar to gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein 1172529 912847 ECs1075 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309102.1 1171759 D 386585 CDS NP_309103.1 15830330 912746 1172545..1172958 1 NC_002695.1 hypothetical protein 1172958 912746 ECs1076 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309103.1 1172545 D 386585 CDS NP_309104.1 15830331 912741 complement(1173310..1174083) 1 NC_002695.1 similar to hypothetical proteins e.g. IroE [Salmonella enterica] gi|2738251|gb|AAC46182.1; hypothetical protein 1174083 912741 ECs1077 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309104.1 1173310 R 386585 CDS NP_309107.1 15830334 912864 1174631..1174843 1 NC_002695.1 similar to Hok/Gef family e.g. MokW [Bacteriophage 933W] AAD25481.1; prophage maintenance protein 1174843 912864 ECs1080 Escherichia coli O157:H7 str. Sakai prophage maintenance protein NP_309107.1 1174631 D 386585 CDS NP_309108.1 15830335 913001 1175011..1175289 1 NC_002695.1 similar to QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1; hypothetical protein 1175289 913001 ECs1081 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309108.1 1175011 D 386585 CDS NP_309109.2 38703910 914088 1175291..1176340 1 NC_002695.1 hypothetical protein 1176340 914088 ECs1082 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309109.2 1175291 D 386585 CDS NP_309110.1 15830337 912434 1176353..1176724 1 NC_002695.1 similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1; similar tocrossover junction endodeoxyribonuclease Rus [Escherichia coli cryptic prophage DLP12] gi|2; crossover junction endodeoxyribonuclease 1176724 912434 ECs1083 Escherichia coli O157:H7 str. Sakai crossover junction endodeoxyribonuclease NP_309110.1 1176353 D 386585 CDS NP_309111.1 15830338 912786 1176714..1177085 1 NC_002695.1 similar to bacteriophage antitermination proteins e.g. YbcQ [Escherichia coli cryptic prophage DLP12 gi|4585416|gb|AAD25444.1|AF125520_39; anti-termination protein 1177085 912786 ECs1084 Escherichia coli O157:H7 str. Sakai anti-termination protein NP_309111.1 1176714 D 386585 CDS NP_309112.1 15830339 912828 1177237..1178055 1 NC_002695.1 similar to YpbD [Bacillus subtilis] gi|1730886|sp|P50730|YPBD_BACSU; hypothetical protein 1178055 912828 ECs1085 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309112.1 1177237 D 386585 CDS NP_309114.1 15830341 912622 1178802..1179389 1 NC_002695.1 similar to transcriptional regulators e.g. YhiW [Escherichia coli] gi|586679|sp|P37638|YHIW_ECOLI; transcriptional regulator 1179389 912622 ECs1087 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_309114.1 1178802 D 386585 CDS NP_309115.1 15830342 912433 1180157..1182007 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 1182007 912433 ECs1088 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309115.1 1180157 D 386585 CDS NP_309116.1 15830343 914098 1182183..1182509 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 1182509 914098 ECs1089 Escherichia coli O157:H7 str. Sakai transposase NP_309116.1 1182183 D 386585 CDS NP_309117.1 15830344 913026 1182506..1183159 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposases e.g. [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 1183159 913026 ECs1090 Escherichia coli O157:H7 str. Sakai transposase NP_309117.1 1182506 D 386585 CDS NP_309119.1 15830346 913584 complement(1184144..1184611) 1 NC_002695.1 similar to endopeptidases e.g. [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1; endopeptidase 1184611 913584 ECs1093 Escherichia coli O157:H7 str. Sakai endopeptidase NP_309119.1 1184144 R 386585 CDS NP_309121.1 15830348 912537 complement(1184613..1184726) 1 NC_002695.1 hypothetical protein 1184726 912537 ECs1094 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309121.1 1184613 R 386585 CDS NP_309123.1 15830350 913013 complement(1184947..1185480) 1 NC_002695.1 similar to endolysins e.g. [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1; endolysin 1185480 913013 ECs1096 Escherichia coli O157:H7 str. Sakai endolysin NP_309123.1 1184947 R 386585 CDS NP_309124.1 15830351 912554 complement(1185513..1185707) 1 NC_002695.1 hypothetical protein 1185707 912554 ECs1098 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309124.1 1185513 R 386585 CDS NP_309125.1 15830352 912597 1185676..1185912 1 NC_002695.1 hypothetical protein 1185912 912597 ECs1097 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309125.1 1185676 D 386585 CDS NP_309126.1 15830353 917142 1185861..1186205 1 NC_002695.1 hypothetical protein 1186205 917142 ECs1099 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309126.1 1185861 D 386585 CDS NP_309127.1 15830354 912580 complement(1186168..1186374) 1 NC_002695.1 similar to holin [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1; holin 1186374 912580 ECs1100 Escherichia coli O157:H7 str. Sakai holin NP_309127.1 1186168 R 386585 CDS NP_309128.1 15830355 913754 1187125..1187400 1 NC_002695.1 hypothetical protein 1187400 913754 ECs1101 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309128.1 1187125 D 386585 CDS NP_309129.1 15830356 913905 1187476..1187856 1 NC_002695.1 similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1; hypothetical protein 1187856 913905 ECs1102 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309129.1 1187476 D 386585 CDS NP_309130.1 15830357 912945 1187853..1188200 1 NC_002695.1 similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933] gi|3414882|gb|AAC31493.1; hypothetical protein 1188200 912945 ECs1103 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309130.1 1187853 D 386585 CDS NP_309131.1 15830358 912757 1188250..1189788 1 NC_002695.1 similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1; hypothetical protein 1189788 912757 ECs1104 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309131.1 1188250 D 386585 CDS NP_309133.1 15830360 913831 1190052..1191980 1 NC_002695.1 similar to terminase large subunit [Bacteriophage 21] gi|2851579|sp|P36693|TERL_BPP21; terminase large subunit 1191980 913831 ECs1106 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_309133.1 1190052 D 386585 CDS NP_944588.1 38703911 2693815 1191964..1192170 1 NC_002695.1 hypothetical protein 1192170 2693815 ECs5406 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944588.1 1191964 D 386585 CDS NP_309134.1 15830361 912594 1192167..1193759 1 NC_002695.1 similar to portal proteins e.g. GP4 [Bacteriophage P21] gi|549295|sp|P36272|VG04_BPP21; portal protein 1193759 912594 ECs1107 Escherichia coli O157:H7 str. Sakai portal protein NP_309134.1 1192167 D 386585 CDS NP_309135.1 15830362 912656 1193749..1195254 1 NC_002695.1 similar to head-tail preconnector proteins e.g. Gp5 [Bacteriophage P21] gi|549296|sp|P36273|VG05_BPP21; head-tail preconnector protein 1195254 912656 ECs1108 Escherichia coli O157:H7 str. Sakai head-tail preconnector protein NP_309135.1 1193749 D 386585 CDS NP_309136.1 15830363 912349 1195291..1195638 1 NC_002695.1 similar to head decoration proteins e.g. Gpshp [Bacteriophage P21] gi|549437|sp|P36275|VSHP_BPP21; head decoration protein 1195638 912349 ECs1109 Escherichia coli O157:H7 str. Sakai head decoration protein NP_309136.1 1195291 D 386585 CDS NP_309137.1 15830364 915170 1195696..1195962 1 NC_002695.1 similar to N-terminal parts of major head proteins e.g. Gp7 [Bacteriophage P21] gi|547612|sp|P36270|HEAD_BPP21; major head protein 1195962 915170 ECs1110 Escherichia coli O157:H7 str. Sakai major head protein NP_309137.1 1195696 D 386585 CDS NP_309138.1 15830365 912499 1196079..1196684 1 NC_002695.1 hypothetical protein 1196684 912499 ECs1111 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309138.1 1196079 D 386585 CDS NP_309139.2 38703912 915165 1196698..1197129 1 NC_002695.1 similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 1197129 915165 ECs1112 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309139.2 1196698 D 386585 CDS NP_309140.1 15830367 912414 1197180..1197569 1 NC_002695.1 similar to minor tail proteins GpG-T [Bacteriophage lambda] gi|7429179|pir||TLBPTL; probably produced by translational frameshift; minor tail protein 1197569 912414 ECs1113 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309140.1 1197180 D 386585 CDS NP_309141.1 15830368 915164 1197550..1200129 1 NC_002695.1 tail length determinator; similar to tail length tape measure proteins e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 1200129 915164 ECs1114 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_309141.1 1197550 D 386585 CDS NP_309142.1 15830369 912914 1200126..1200455 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1200455 912914 ECs1115 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309142.1 1200126 D 386585 CDS NP_309143.1 15830370 912440 1200455..1201153 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1201153 912440 ECs1116 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309143.1 1200455 D 386585 CDS NP_309144.1 15830371 912587 1201272..1201907 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 1201907 912587 ECs1117 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_309144.1 1201272 D 386585 CDS NP_309145.1 15830372 912997 1201805..1202485 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1202485 912997 ECs1118 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_309145.1 1201805 D 386585 CDS NP_309146.1 15830373 912655 1202439..1202645 1 NC_002695.1 hypothetical protein 1202645 912655 ECs1119 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309146.1 1202439 D 386585 CDS NP_309147.1 15830374 912575 complement(1202676..1203203) 1 NC_002695.1 similar to copper/zinc-superoxide dismutases e.g. [Salmonella typhimurium] gi|2462699|emb|CAA73588.1; copper/zinc-superoxide dismutase 1203203 912575 ECs1120 Escherichia coli O157:H7 str. Sakai copper/zinc-superoxide dismutase NP_309147.1 1202676 R 386585 CDS NP_309148.1 15830375 912880 1203337..1206810 1 NC_002695.1 similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1206810 912880 ECs1121 Escherichia coli O157:H7 str. Sakai host specificity protein NP_309148.1 1203337 D 386585 CDS NP_309149.1 15830376 914035 1206878..1207477 1 NC_002695.1 similar to Lom outer membrane proteins e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein 1207477 914035 ECs1122 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309149.1 1206878 D 386585 CDS NP_309150.1 15830377 912411 1207536..1208855 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 1208855 912411 ECs1123 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_309150.1 1207536 D 386585 CDS NP_309151.1 15830378 912563 1208857..1209126 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; similar to tail protein of 933W gi|4585436|gb|AAD25464.1|AF125520_59; hypothetical protein 1209126 912563 ECs1124 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309151.1 1208857 D 386585 CDS NP_309152.1 15830379 915162 complement(1209251..1209820) 1 NC_002695.1 probable secreted effector protein; similar to EspF proteins e.g. [Escherichia coli strain E2348/69] gi|2865308|gb|AAC38400.1; similar toL0016 - Escherichia coli gi|3414884|gb|AAC31495.1; EspF-like protein 1209820 915162 ECs1126 Escherichia coli O157:H7 str. Sakai EspF-like protein NP_309152.1 1209251 R 386585 CDS NP_309153.1 15830380 915169 1209796..1209978 1 NC_002695.1 hypothetical protein 1209978 915169 ECs1125 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309153.1 1209796 D 386585 CDS NP_309154.1 15830381 912464 complement(1210459..1210641) 1 NC_002695.1 similar to avirulence protein A [Pseudomonas syringae] gi|114726|sp|P11437|AVRA_PSESG; hypothetical protein 1210641 912464 ECs1127 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309154.1 1210459 R 386585 CDS NP_309155.1 15830382 912588 1211259..1212377 1 NC_002695.1 similar to HYAA_ECOLI gi|1787206 (conserved in Escherichia coli K-12); hydrogenase-1 small subunit 1212377 912588 ECs1128 Escherichia coli O157:H7 str. Sakai hydrogenase-1 small subunit NP_309155.1 1211259 D 386585 CDS NP_309156.1 15830383 912492 1212374..1214167 1 NC_002695.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1214167 912492 ECs1129 Escherichia coli O157:H7 str. Sakai hydrogenase 1 large subunit NP_309156.1 1212374 D 386585 CDS NP_309157.1 15830384 912637 1214186..1214893 1 NC_002695.1 similar to HYAC_ECOLI gi|1787208 (conserved in Escherichia coli K-12); hydrogenase 1 b-type cytochrome subunit 1214893 912637 ECs1130 Escherichia coli O157:H7 str. Sakai hydrogenase 1 b-type cytochrome subunit NP_309157.1 1214186 D 386585 CDS NP_309158.1 15830385 912497 1214890..1215477 1 NC_002695.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1215477 912497 ECs1131 Escherichia coli O157:H7 str. Sakai hydrogenase 1 maturation protease NP_309158.1 1214890 D 386585 CDS NP_309159.1 15830386 912590 1215474..1215872 1 NC_002695.1 involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1215872 912590 ECs1132 Escherichia coli O157:H7 str. Sakai hydrogenase-1 operon protein HyaE NP_309159.1 1215474 D 386585 CDS NP_309160.1 15830387 914195 1215869..1216726 1 NC_002695.1 similar to HYAF_ECOLI gi|1787211 (conserved in Escherichia coli K-12); hydrogenase-1 operon protein HyaF 1216726 914195 ECs1133 Escherichia coli O157:H7 str. Sakai hydrogenase-1 operon protein HyaF NP_309160.1 1215869 D 386585 CDS NP_309161.1 15830388 912583 1216860..1218404 1 NC_002695.1 similar to APPC_ECOLI gi|1787212 (conserved in Escherichia coli K-12); third cytochrome oxidase subunit I 1218404 912583 ECs1134 Escherichia coli O157:H7 str. Sakai third cytochrome oxidase subunit I NP_309161.1 1216860 D 386585 CDS NP_309162.1 15830389 912596 1218416..1219552 1 NC_002695.1 similar to APPB_ECOLI gi|1787213 (conserved in Escherichia coli K-12); third cytochrome oxidase subunit II 1219552 912596 ECs1135 Escherichia coli O157:H7 str. Sakai third cytochrome oxidase subunit II NP_309162.1 1218416 D 386585 CDS NP_309163.1 15830390 912585 1219737..1221041 1 NC_002695.1 similar to phosphoanhydride phosphorylase APPA_ECOLI gi|1787215 (conserved in Escherichia coli K-12); phosphoanhydride phosphorylase 1221041 912585 ECs1136 Escherichia coli O157:H7 str. Sakai phosphoanhydride phosphorylase NP_309163.1 1219737 D 386585 CDS NP_309164.1 15830391 912586 complement(1221161..1223341) 1 NC_002695.1 similar to YCCC_ECOLI gi|1787216 (conserved in Escherichia coli K-12); cryptic autophosphorylating protein tyrosine kinase Etk 1223341 912586 ECs1137 Escherichia coli O157:H7 str. Sakai cryptic autophosphorylating protein tyrosine kinase Etk NP_309164.1 1221161 R 386585 CDS NP_309165.2 38703913 914076 complement(1223361..1223807) 1 NC_002695.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1223807 etp 914076 etp Escherichia coli O157:H7 str. Sakai phosphotyrosine-protein phosphatase NP_309165.2 1223361 R 386585 CDS NP_309166.1 15830393 915179 complement(1223795..1224934) 1 NC_002695.1 function in exopolysaccharide production; similar to YCCZ_ECOLI gi|1787218 (conserved in Escherichia coli K-12); hypothetical protein 1224934 915179 ECs1139 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309166.1 1223795 R 386585 CDS NP_309167.1 15830394 912530 complement(1224980..1227076) 1 NC_002695.1 similar to YMCA_ECOLI gi|1787219 (conserved in Escherichia coli K-12); hypothetical protein 1227076 912530 ECs1140 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309167.1 1224980 R 386585 CDS NP_309168.1 15830395 914107 complement(1227076..1227822) 1 NC_002695.1 similar to YMCB_ECOLI gi|1787220 (conserved in Escherichia coli K-12); hypothetical protein 1227822 914107 ECs1141 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309168.1 1227076 R 386585 CDS NP_309169.1 15830396 913925 complement(1227819..1228463) 1 NC_002695.1 similar to YMCC_ECOLI gi|1787221 (conserved in Escherichia coli K-12); regulator 1228463 913925 ECs1142 Escherichia coli O157:H7 str. Sakai regulator NP_309169.1 1227819 R 386585 CDS NP_309170.1 15830397 912571 complement(1228570..1228893) 1 NC_002695.1 similar to YMCD_ECOLI gi|1787222 (conserved in Escherichia coli K-12); hypothetical protein 1228893 912571 ECs1143 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309170.1 1228570 R 386585 CDS NP_309171.1 15830398 912600 complement(1229317..1229529) 1 NC_002695.1 similar to CSPH_ECOLI gi|2367112 (conserved in Escherichia coli K-12); cold shock-like protein 1229529 912600 ECs1144 Escherichia coli O157:H7 str. Sakai cold shock-like protein NP_309171.1 1229317 R 386585 CDS NP_309172.1 15830399 912577 1229815..1230027 1 NC_002695.1 similar to CSPG_ECOLI gi|2367114 (conserved in Escherichia coli K-12); cold shock protein CspG 1230027 912577 ECs1145 Escherichia coli O157:H7 str. Sakai cold shock protein CspG NP_309172.1 1229815 D 386585 CDS NP_309173.1 15830400 913646 1230201..1230431 1 NC_002695.1 similar to SFA_ECOLI gi|1787225 (conserved in Escherichia coli K-12); cold shock gene 1230431 913646 ECs1146 Escherichia coli O157:H7 str. Sakai cold shock gene NP_309173.1 1230201 D 386585 CDS NP_309174.1 15830401 913544 complement(1230642..1231715) 1 NC_002695.1 similar to YCCM_ECOLI gi|1787226 (conserved in Escherichia coli K-12); hypothetical protein 1231715 913544 ECs1147 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309174.1 1230642 R 386585 CDS NP_309175.2 162139802 913641 complement(1231787..1234531) 1 NC_002695.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1234531 913641 ECs1148 Escherichia coli O157:H7 str. Sakai hybrid sensory histidine kinase TorS NP_309175.2 1231787 R 386585 CDS NP_309176.1 15830403 913730 1234614..1235642 1 NC_002695.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1235642 913730 ECs1149 Escherichia coli O157:H7 str. Sakai TMAO reductase system periplasmic protein TorT NP_309176.1 1234614 D 386585 CDS NP_309177.1 15830404 914140 complement(1235615..1236307) 1 NC_002695.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1236307 914140 ECs1150 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator TorR NP_309177.1 1235615 R 386585 CDS NP_309178.1 15830405 912595 1236437..1237609 1 NC_002695.1 similar to TORC_ECOLI gi|1787230 (conserved in Escherichia coli K-12); trimethylamine N-oxide reductase cytochrome c-type subunit 1237609 912595 ECs1151 Escherichia coli O157:H7 str. Sakai trimethylamine N-oxide reductase cytochrome c-type subunit NP_309178.1 1236437 D 386585 CDS NP_309179.1 15830406 913030 1237609..1240155 1 NC_002695.1 similar to TORA_ECOLI gi|1787231 (conserved in Escherichia coli K-12); trimethylamine N-oxide reductase subunit 1240155 913030 ECs1152 Escherichia coli O157:H7 str. Sakai trimethylamine N-oxide reductase subunit NP_309179.1 1237609 D 386585 CDS NP_309180.1 15830407 912584 1240152..1240751 1 NC_002695.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1240751 torD 912584 torD Escherichia coli O157:H7 str. Sakai chaperone protein TorD NP_309180.1 1240152 D 386585 CDS NP_309181.1 15830408 915178 complement(1240905..1241210) 1 NC_002695.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1241210 915178 ECs1154 Escherichia coli O157:H7 str. Sakai chaperone-modulator protein CbpM NP_309181.1 1240905 R 386585 CDS NP_309182.1 15830409 913525 complement(1241210..1242130) 1 NC_002695.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1242130 913525 ECs1155 Escherichia coli O157:H7 str. Sakai curved DNA-binding protein CbpA NP_309182.1 1241210 R 386585 CDS NP_309185.1 15830412 913790 1243938..1245179 1 NC_002695.1 similar to AGP_ECOLI gi|1787237 (conserved in Escherichia coli K-12); glucose-1-phosphatase/inositol phosphatase 1245179 913790 ECs1158 Escherichia coli O157:H7 str. Sakai glucose-1-phosphatase/inositol phosphatase NP_309185.1 1243938 D 386585 CDS NP_309186.1 15830413 913848 complement(1245217..1245444) 1 NC_002695.1 similar to YCCJ_ECOLI gi|1787238 (conserved in Escherichia coli K-12); hypothetical protein 1245444 913848 ECs1159 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309186.1 1245217 R 386585 CDS YP_004935383.1 359268811 11451195 complement(1245465..1246010) 1 NC_002695.1 TrpR binding protein WrbA 1246010 wrbA 11451195 wrbA Escherichia coli O157:H7 str. Sakai TrpR binding protein WrbA YP_004935383.1 1245465 R 386585 CDS NP_309187.1 15830414 912564 complement(1246040..1247350) 1 NC_002695.1 similar to integrase [Bacteriophage 933W] gi|4585378|gb|AAD25406.1|AF125520_1 and [Escherichia coli rac prophage] gi|6166234|sp|P76056|INTR_ECOLI; integrase 1247350 912564 ECs1160 Escherichia coli O157:H7 str. Sakai integrase NP_309187.1 1246040 R 386585 CDS NP_309188.1 15830415 912465 complement(1247403..1247687) 1 NC_002695.1 similar to excisionase [Bacteriophage 933W] gi|4585379|gb|AAD25407.1|AF125520_2; excisionase 1247687 912465 ECs1161 Escherichia coli O157:H7 str. Sakai excisionase NP_309188.1 1247403 R 386585 CDS NP_309189.1 15830416 912355 complement(1247773..1248084) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585380|gb|AAD25408.1|AF125520_3; hypothetical protein 1248084 912355 ECs1162 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309189.1 1247773 R 386585 CDS NP_309190.1 15830417 912616 complement(1248144..1248488) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585381|gb|AAD25409.1|AF125520_4; hypothetical protein 1248488 912616 ECs1163 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309190.1 1248144 R 386585 CDS NP_309191.1 15830418 912910 complement(1248421..1249044) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585382|gb|AAD25410.1|AF125520_5; similar to hypothetical protein [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein 1249044 912910 ECs1164 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309191.1 1248421 R 386585 CDS NP_309192.1 15830419 912740 complement(1249048..1249335) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585383|gb|AAD25411.1|AF125520_6; hypothetical protein 1249335 912740 ECs1165 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309192.1 1249048 R 386585 CDS NP_309193.1 15830420 915194 complement(1249337..1249555) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585384|gb|AAD25412.1|AF125520_7; hypothetical protein 1249555 915194 ECs1166 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309193.1 1249337 R 386585 CDS NP_309194.1 15830421 913027 complement(1249557..1249844) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585385|gb|AAD25413.1|AF125520_8; hypothetical protein 1249844 913027 ECs1167 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309194.1 1249557 R 386585 CDS NP_309195.1 15830422 912386 complement(1249774..1250241) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881600|dbj|BAA84291.1; hypothetical protein 1250241 912386 ECs1168 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309195.1 1249774 R 386585 CDS NP_309196.1 15830423 913040 complement(1250114..1250887) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585386|gb|AAD25414.1|AF125520_9, similar to hypothetical protein [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein 1250887 913040 ECs1169 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309196.1 1250114 R 386585 CDS NP_309197.1 15830424 913822 complement(1250884..1251105) 1 NC_002695.1 similar to C4-type zinc finger proteins (TraR family) e.g. gi|4585456|gb|AAD25484.1|AF125520_79; C4-type zinc finger TraR 1251105 913822 ECs1170 Escherichia coli O157:H7 str. Sakai C4-type zinc finger TraR NP_309197.1 1250884 R 386585 CDS NP_309198.1 15830425 912986 complement(1251204..1251419) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W]; similar to orf61 [Bacteriophage lambda] gi|508993|gb|AAA96566.1; hypothetical protein 1251419 912986 ECs1171 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309198.1 1251204 R 386585 CDS NP_309199.1 15830426 914108 complement(1251496..1251687) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881603|dbj|BAA84294.1|, similar to orf63 [Bacteriophage lambda] gi|508994|gb|AAA96567.1; hypothetical protein 1251687 914108 ECs1172 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309199.1 1251496 R 386585 CDS NP_309200.1 15830427 912448 complement(1251660..1251842) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881604|dbj|BAA84295.1, similar to orf60a [Bacteriophage lambda] gi|508995|gb|AAA96568.1; hypothetical protein 1251842 912448 ECs1173 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309200.1 1251660 R 386585 CDS NP_309201.1 15830428 912450 complement(1251839..1252519) 1 NC_002695.1 similar to exonuclease [Bacteriophage lambda] gi|2981722|pdb|1AVQ|A; exonuclease 1252519 912450 ECs1174 Escherichia coli O157:H7 str. Sakai exonuclease NP_309201.1 1251839 R 386585 CDS NP_309202.1 15830429 913518 complement(1252516..1253301) 1 NC_002695.1 similar to Bet [Bacteriophage VT2-Sa] gi|5881606|dbj|BAA84297.1 and [Bacteriophage lambda] gi|137511|sp|P03698|VBET_LAMBD; recombination protein Bet 1253301 913518 ECs1175 Escherichia coli O157:H7 str. Sakai recombination protein Bet NP_309202.1 1252516 R 386585 CDS NP_309203.1 15830430 913719 complement(1253307..1253723) 1 NC_002695.1 host-nuclease inhibitor protein; similar to Gam protein [Bacteriophage lambda] gi|138128|sp|P03702|VGAM_LAMBD; hypothetical protein 1253723 913719 ECs1176 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309203.1 1253307 R 386585 CDS NP_309204.1 15830431 912898 complement(1253678..1253947) 1 NC_002695.1 similar to kil [Bacteriophage VT2-Sa] gi|5881608|dbj|BAA84299.1 and [Bacteriophage lambda] gi|138622|sp|P03758|VKIL_LAMBD; Kil protein 1253947 912898 ECs1177 Escherichia coli O157:H7 str. Sakai Kil protein NP_309204.1 1253678 R 386585 CDS NP_309205.1 15830432 912643 complement(1253790..1253954) 1 NC_002695.1 antitermination; similar to cIII [Bacteriophage lambda] gi|133366|sp|P03044|RPC3_LAMBD; regulatory protein cIII 1253954 912643 ECs1178 Escherichia coli O157:H7 str. Sakai regulatory protein cIII NP_309205.1 1253790 R 386585 CDS NP_309206.1 15830433 912933 complement(1254027..1254395) 1 NC_002695.1 single strand binding protein; similar to Ea10 [Bacteriophage VT2-Sa] gi|5881610|dbj|BAA84301.1 and [Bacteriophage lambda] gi|137630|sp|P03757|VE10_LAMBD; hypothetical protein 1254395 912933 ECs1179 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309206.1 1254027 R 386585 CDS NP_309207.1 15830434 913005 complement(1254578..1254829) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881612|dbj|BAA84303.1; hypothetical protein 1254829 913005 ECs1180 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309207.1 1254578 R 386585 CDS NP_309208.1 15830435 914151 complement(1254888..1255160) 1 NC_002695.1 similar to N protein [Bacteriophage VT2-Sa] gi|5881613|dbj|BAA84304.1 and [Bacteriophage 933W] gi|4585397|gb|AAD25425.1|AF125520_20; hypothetical protein 1255160 914151 ECs1181 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309208.1 1254888 R 386585 CDS NP_309209.1 15830436 912920 complement(1255138..1255320) 1 NC_002695.1 hypothetical protein 1255320 912920 ECs1182 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309209.1 1255138 R 386585 CDS NP_309210.1 15830437 912491 1255617..1255778 1 NC_002695.1 hypothetical protein 1255778 912491 ECs1183 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309210.1 1255617 D 386585 CDS NP_309211.1 15830438 912589 complement(1255889..1256410) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881614|dbj|BAA84305.1; hypothetical protein 1256410 912589 ECs1184 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309211.1 1255889 R 386585 CDS NP_309212.1 15830439 912404 complement(1256912..1257565) 1 NC_002695.1 similar to cI [Bacteriophage lambda] gi|133353|sp|P03034|RPC1_LAMBD; cI repressor protein 1257565 912404 ECs1185 Escherichia coli O157:H7 str. Sakai cI repressor protein NP_309212.1 1256912 R 386585 CDS NP_309213.1 15830440 912935 1257683..1257898 1 NC_002695.1 probable regulatory protein, similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881616|dbj|BAA84307.1 and c2 [Bacteriophage L] gi|1469215|emb|CAA63999.1; CRO 1257898 912935 ECs1186 Escherichia coli O157:H7 str. Sakai CRO NP_309213.1 1257683 D 386585 CDS NP_309214.1 15830441 914205 1258040..1258336 1 NC_002695.1 regulatory protein; similar to CII [Bacteriophage VT2-Sa] gi|5881617|dbj|BAA84308.1 and [Enterobacteria phage HK022] gi|631957|pir||S42398; hypothetical protein 1258336 914205 ECs1187 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309214.1 1258040 D 386585 CDS NP_309215.1 15830442 913718 1258369..1258515 1 NC_002695.1 similar to hypothetical protein [Enterobacteria phage HK022] gi|632160|pir||S42399, orf48 [Bacteriophage P22] gi|871503|emb|CAA55155.1; hypothetical protein 1258515 913718 ECs1188 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309215.1 1258369 D 386585 CDS NP_309216.1 15830443 912502 1258508..1259407 1 NC_002695.1 similar to O proteins e.g. O [Enterobacteria phage HK022] gi|407289|gb|AAB60272.1; replication protein O 1259407 912502 ECs1189 Escherichia coli O157:H7 str. Sakai replication protein O NP_309216.1 1258508 D 386585 CDS NP_309217.1 15830444 912972 1259382..1260833 1 NC_002695.1 replicative DNA helicase; similar to P protein [Enterobacteria phage HK022] gi|6863143|gb|AAF30384.1|AF069308_32, replicative DNA helicase DnaB [Escherichia col; replication protein P 1260833 912972 ECs1190 Escherichia coli O157:H7 str. Sakai replication protein P NP_309217.1 1259382 D 386585 CDS NP_309218.1 15830445 914143 1260833..1261102 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881620|dbj|BAA84311.1; hypothetical protein 1261102 914143 ECs1191 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309218.1 1260833 D 386585 CDS NP_309219.1 15830446 912446 1261173..1261451 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4499788|emb|CAB39287.1; hypothetical protein 1261451 912446 ECs1192 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309219.1 1261173 D 386585 CDS NP_309220.1 15830447 913833 1261584..1261799 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4499789|emb|CAB39288.1; hypothetical protein 1261799 913833 ECs1193 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309220.1 1261584 D 386585 CDS NP_309221.1 15830448 914070 1261810..1262046 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881622|dbj|BAA84313.1 and [Bacteriophage 933W] gi|4499790|emb|CAB39289.1; hypothetical protein 1262046 914070 ECs1194 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309221.1 1261810 D 386585 CDS NP_309222.1 15830449 912513 1262003..1262449 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881623|dbj|BAA84314.1 and NinB protein [Bacteriophage 21]; hypothetical protein 1262449 912513 ECs1195 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309222.1 1262003 D 386585 CDS NP_309223.1 15830450 913996 1262446..1262973 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881624|dbj|BAA84315.1 and Gp62 [Bacteriophage HK97] gi|6901634|gb|AAF31137.1; DNA methylase 1262973 913996 ECs1196 Escherichia coli O157:H7 str. Sakai DNA methylase NP_309223.1 1262446 D 386585 CDS NP_309224.1 15830451 913015 1262970..1263152 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881625|dbj|BAA84316.1 and NinE protein [Bacteriophage 21] gi|4539480|emb|CAB39989.1; protein NinE 1263152 913015 ECs1197 Escherichia coli O157:H7 str. Sakai protein NinE NP_309224.1 1262970 D 386585 CDS NP_309226.1 15830453 913580 1263427..1264161 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881627|dbj|BAA84318.1 and antirepressor protein Ant [Bacteriophage P22]; antirepressor protein 1264161 913580 ECs1199 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_309226.1 1263427 D 386585 CDS NP_309227.1 15830454 913662 1264236..1264958 1 NC_002695.1 similar to Roi [Bacteriophage VT2-Sa] gi|5881628|dbj|BAA84319.1 and Roi proteins e.g. [Enterobacteria phage HK022] gi|1197729|gb|AAC48863.1; DNA-binding protein 1264958 913662 ECs1200 Escherichia coli O157:H7 str. Sakai DNA-binding protein NP_309227.1 1264236 D 386585 CDS NP_309228.1 15830455 912371 1264958..1265563 1 NC_002695.1 similar to hypothetical protein orf15 [Bacteriophage 933W] gi|4499798|emb|CAB39297.1 and NinG protein [Bacteriophage 21] gi|4539482|emb|CAB39991.1; protein NinG 1265563 912371 ECs1201 Escherichia coli O157:H7 str. Sakai protein NinG NP_309228.1 1264958 D 386585 CDS NP_309229.1 15830456 912456 1265560..1265754 1 NC_002695.1 similar to hypothetical protein orf16 [Bacteriophage 933W] gi|4499799|emb|CAB39298.1 and hypothetical proteins e.g. Nin68 [Bacteriophage lambda] gi|9626304|ref|NP_040640.1; hypothetical protein 1265754 912456 ECs1202 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309229.1 1265560 D 386585 CDS NP_309230.1 15830457 913671 1265747..1266181 1 NC_002695.1 similar to antitermination protein Q [Bacteriophage 933W] gi|4585416|gb|AAD25444.1|AF125520_39 and antitermination Q proteins e.g. [Bacteriophage H-19B] gi|2668768|gb|AAD04655.1; antitermination protein Q 1266181 913671 ECs1203 Escherichia coli O157:H7 str. Sakai antitermination protein Q NP_309230.1 1265747 D 386585 CDS NP_309231.1 15830458 912801 1266430..1266582 1 NC_002695.1 similar to hypothetical protein [Bacteriophage P27] gi|8346570|emb|CAB93763.1|; hypothetical protein 1266582 912801 ECs1204 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309231.1 1266430 D 386585 CDS NP_309232.1 15830459 912807 1266965..1267924 1 NC_002695.1 similar to gi|1351074|sp|P09385|SLTA_BP933; Shiga toxin 2 subunit A 1267924 912807 ECs1205 Escherichia coli O157:H7 str. Sakai Shiga toxin 2 subunit A NP_309232.1 1266965 D 386585 CDS NP_309233.1 15830460 912579 1267936..1268205 1 NC_002695.1 similar to gi|134538|sp|P09386|SLTB_BP933; Shiga toxin 2 subunit B 1268205 912579 ECs1206 Escherichia coli O157:H7 str. Sakai Shiga toxin 2 subunit B NP_309233.1 1267936 D 386585 CDS NP_309234.1 15830461 912907 1268692..1270596 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42 and YjhS [Shigella dysenteriae] gi|6759965|gb|; hypothetical protein 1270596 912907 ECs1207 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309234.1 1268692 D 386585 CDS NP_309235.1 15830462 914040 complement(1270403..1271293) 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 1271293 914040 ECs1208 Escherichia coli O157:H7 str. Sakai transposase NP_309235.1 1270403 R 386585 CDS NP_309236.1 15830463 912762 complement(1271290..1271616) 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase 1271616 912762 ECs1209 Escherichia coli O157:H7 str. Sakai transposase NP_309236.1 1271290 R 386585 CDS NP_309237.1 15830464 912298 1272078..1272257 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4499806|emb|CAB39305.1; hypothetical protein 1272257 912298 ECs1210 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309237.1 1272078 D 386585 CDS NP_309238.2 38703914 912967 1272298..1272570 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585420|gb|AAD25448.1|AF125520_43; hypothetical protein 1272570 912967 ECs1211 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309238.2 1272298 D 386585 CDS NP_309239.1 15830466 913732 1272647..1272862 1 NC_002695.1 similar to protein S [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1 and [Shigella dysenteriae] gi|6759967|gb|AAF28125.1|AF153317_21; holin 1272862 913732 ECs1212 Escherichia coli O157:H7 str. Sakai holin NP_309239.1 1272647 D 386585 CDS NP_309240.1 15830467 913680 1272867..1273400 1 NC_002695.1 similar to endolysin [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45 and endolysins e.g. [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1; endolysin 1273400 913680 ECs1213 Escherichia coli O157:H7 str. Sakai endolysin NP_309240.1 1272867 D 386585 CDS NP_309241.1 15830468 912535 1273671..1274240 1 NC_002695.1 similar to antirepressor protein [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46 and antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1274240 912535 ECs1214 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_309241.1 1273671 D 386585 CDS NP_309242.1 15830469 912904 1274394..1274858 1 NC_002695.1 similar to endopeptidase [Bacteriophage 933W] gi|4585424|gb|AAD25452.1|AF125520_47 and Rz [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 1274858 912904 ECs1215 Escherichia coli O157:H7 str. Sakai endopeptidase NP_309242.1 1274394 D 386585 CDS NP_309244.1 15830471 913557 complement(1274890..1275183) 1 NC_002695.1 similar to [Bacteriophage 933W] gi|4585426|gb|AAD25454.1|AF125520_49 and Bor protein precursor [Bacteriophage lambda] gi|137520|sp|P26814|VBOR_LAMBD; Bor protein 1275183 913557 ECs1217 Escherichia coli O157:H7 str. Sakai Bor protein NP_309244.1 1274890 R 386585 CDS NP_309245.2 38703915 913530 1275291..1275536 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881640|dbj|BAA84331.1; hypothetical protein 1275536 913530 ECs1218 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309245.2 1275291 D 386585 CDS NP_309246.1 15830473 912647 1275592..1276398 1 NC_002695.1 similar to small subunit terminase [Bacteriophage 933W] gi|4585427|gb|AAD25455.1|AF125520_50; small subunit terminase 1276398 912647 ECs1219 Escherichia coli O157:H7 str. Sakai small subunit terminase NP_309246.1 1275592 D 386585 CDS NP_309247.1 15830474 912871 1276379..1278085 1 NC_002695.1 similar to terminase large subunit [Bacteriophage 933W] gi|4585428|gb|AAD25456.1|AF125520_51; terminase large subunit 1278085 912871 ECs1220 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_309247.1 1276379 D 386585 CDS NP_309248.1 15830475 912727 1278085..1280229 1 NC_002695.1 similar to portal protein [Bacteriophage 933W] gi|4585429|gb|AAD25457.1|AF125520_52; portal protein 1280229 912727 ECs1221 Escherichia coli O157:H7 str. Sakai portal protein NP_309248.1 1278085 D 386585 CDS NP_309249.1 15830476 912459 1280387..1281394 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585430|gb|AAD25458.1|AF125520_53; hypothetical protein 1281394 912459 ECs1222 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309249.1 1280387 D 386585 CDS NP_309250.1 15830477 914220 1281418..1282632 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585431|gb|AAD25459.1|AF125520_54; hypothetical protein 1282632 914220 ECs1223 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309250.1 1281418 D 386585 CDS NP_309251.1 15830478 912617 1282688..1283077 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585432|gb|AAD25460.1|AF125520_55; hypothetical protein 1283077 912617 ECs1224 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309251.1 1282688 D 386585 CDS NP_309252.1 15830479 912613 1283127..1283588 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585433|gb|AAD25461.1|AF125520_56; hypothetical protein 1283588 912613 ECs1225 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309252.1 1283127 D 386585 CDS NP_309253.1 15830480 912959 1283572..1284135 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585434|gb|AAD25462.1|AF125520_57; hypothetical protein 1284135 912959 ECs1226 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309253.1 1283572 D 386585 CDS NP_309254.1 15830481 912471 1284135..1284785 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585435|gb|AAD25463.1|AF125520_58; hypothetical protein 1284785 912471 ECs1227 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309254.1 1284135 D 386585 CDS NP_309255.1 15830482 913841 1284782..1286719 1 NC_002695.1 similar to tail fiber protein [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 1286719 913841 ECs1228 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_309255.1 1284782 D 386585 CDS NP_309256.1 15830483 912963 1286721..1286990 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 1286990 912963 ECs1229 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309256.1 1286721 D 386585 CDS NP_309257.1 15830484 914028 1287076..1287318 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585438|gb|AAD25466.1|AF125520_61; hypothetical protein 1287318 914028 ECs1230 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309257.1 1287076 D 386585 CDS NP_309258.1 15830485 912373 complement(1287205..1287447) 1 NC_002695.1 outer membrane protein 1287447 912373 ECs1231 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309258.1 1287205 R 386585 CDS NP_309259.1 15830486 912738 1287535..1289238 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585439|gb|AAD25467.1|AF125520_62, [Bacteriophage P-EibD] gi|7523538|gb|AAF63043.1|AF151675_5; hypothetical protein 1289238 912738 ECs1232 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309259.1 1287535 D 386585 CDS NP_309260.1 15830487 912610 1289235..1290503 1 NC_002695.1 similar to tail tip fiber protein gp21 [phage N15] gi|7444604|pir||T13107, [Bacteriophage 933W] gi|4585440|gb|AAD25468.1|AF125520_63; probable tail tip fiber protein; tail tip fiber protein 1290503 912610 ECs1233 Escherichia coli O157:H7 str. Sakai tail tip fiber protein NP_309260.1 1289235 D 386585 CDS NP_309261.1 15830488 912632 1290518..1290796 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585441|gb|AAD25469.1|AF125520_64; outer membrane protein 1290796 912632 ECs1234 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309261.1 1290518 D 386585 CDS NP_309262.1 15830489 913928 1290802..1291419 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585442|gb|AAD25470.1|AF125520_65; hypothetical protein 1291419 913928 ECs1235 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309262.1 1290802 D 386585 CDS NP_309263.1 15830490 914208 1291510..1292244 1 NC_002695.1 similar to tail gene products e.g. [Yersinia pseudotuberculosis] gi|5902750|sp|Q56957|AIL_YERPS, outer membrane protein Lom precursor gi|138693|sp|P03701|VLOM_LAMBD, virulence protein pagC precursor [Salmonella typhimurium] gi|129558|sp|P23988|PAGC_SALTY, Lom precursor [Bacteriophage 933W] gi|4585443|gb|AAD25471.1|AF125520_66, outer membrane protein rck [Salmonella typhimurium] gi|282013|pir||A43309; outer membrane protein 1292244 914208 ECs1236 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309263.1 1291510 D 386585 CDS NP_309264.1 15830491 912598 1292674..1293075 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585444|gb|AAD25472.1|AF125520_67; hypothetical protein 1293075 912598 ECs1237 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309264.1 1292674 D 386585 CDS NP_309265.1 15830492 912494 1293169..1293825 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585445|gb|AAD25473.1|AF125520_68; hypothetical protein 1293825 912494 ECs1238 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309265.1 1293169 D 386585 CDS NP_309266.1 15830493 913010 1293828..1294274 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585446|gb|AAD25474.1|AF125520_69; hypothetical protein 1294274 913010 ECs1239 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309266.1 1293828 D 386585 CDS NP_309267.1 15830494 912772 1294284..1294535 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585447|gb|AAD25475.1|AF125520_70; hypothetical protein 1294535 912772 ECs1240 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309267.1 1294284 D 386585 CDS NP_309268.1 15830495 913004 1294546..1295811 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585448|gb|AAD25476.1|AF125520_71; hypothetical protein 1295811 913004 ECs1241 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309268.1 1294546 D 386585 CDS NP_309269.1 15830496 912529 1295881..1304262 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585449|gb|AAD25477.1|AF125520_72; hypothetical protein 1304262 912529 ECs1242 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309269.1 1295881 D 386585 CDS NP_309270.1 15830497 914152 1304548..1304733 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585450|gb|AAD25478.1|AF125520_73; hypothetical protein 1304733 914152 ECs1243 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309270.1 1304548 D 386585 CDS NP_309271.1 15830498 912897 complement(1304813..1305157) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|9632540|ref|NP_049534.1, ygiW protein precursor [Escherichia coli] gi|1723887|sp|P52083|YGIW_ECOLI; hypothetical protein 1305157 912897 ECs1244 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309271.1 1304813 R 386585 CDS NP_309272.1 15830499 913002 complement(1305277..1305489) 1 NC_002695.1 similar to MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76, GelF [Escherichia coli] gi|1786200|gb|AAC73129.1; MokW protein 1305489 913002 ECs1245 Escherichia coli O157:H7 str. Sakai MokW protein NP_309272.1 1305277 R 386585 CDS NP_309273.1 15830500 913862 complement(1305723..1306118) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585454|gb|AAD25482.1|AF125520_77; hypothetical protein 1306118 913862 ECs1246 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309273.1 1305723 R 386585 CDS NP_309274.1 15830501 912992 complement(1306118..1306777) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881668|dbj|BAA84359.1, [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein 1306777 912992 ECs1247 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309274.1 1306118 R 386585 CDS NP_309275.1 15830502 912358 complement(1306798..1307016) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881669|dbj|BAA84360.1, [Bacteriophage 933W] gi|7649907|dbj|BAA94185.1; hypothetical protein 1307016 912358 ECs1248 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309275.1 1306798 R 386585 CDS NP_309276.1 15830503 914137 complement(1307003..1307287) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881670|dbj|BAA84361.1; hypothetical protein 1307287 914137 ECs1249 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309276.1 1307003 R 386585 CDS NP_309277.1 15830504 912642 complement(1307284..1307505) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881671|dbj|BAA84362.1, C4-type zinc finger proteins (TraR family) e.g. orf39 [Pseudomonas aeruginosa phage phi CTX] gi|4063813|dbj|BAA36267; C4-type zinc finger TraR 1307505 912642 ECs1250 Escherichia coli O157:H7 str. Sakai C4-type zinc finger TraR NP_309277.1 1307284 R 386585 CDS NP_309278.1 15830505 912780 complement(1307553..1308182) 1 NC_002695.1 similar to phage anti-repressor proteins e.g. [Neisseria meningitidis] gi|7379969|emb|CAB84545.1, [Bacteriophage VT2-Sa] gi|5881672|dbj|BAA84363.1, HI1422 [Haemophilus influenzae Rd] gi|1175795|sp|P44193|YE22_HAEIN; anti-repressor protein 1308182 912780 ECs1251 Escherichia coli O157:H7 str. Sakai anti-repressor protein NP_309278.1 1307553 R 386585 CDS NP_309279.2 38703916 914118 complement(1309331..1310659) 1 NC_002695.1 similar to YCDG_ECOLI gi|1787241 (conserved in Escherichia coli K-12); transporter 1310659 914118 ECs1252 Escherichia coli O157:H7 str. Sakai transporter NP_309279.2 1309331 R 386585 CDS NP_309280.2 38703917 912887 complement(1310680..1311174) 1 NC_002695.1 similar to B1007_ECOLI gi|1787242 (conserved in Escherichia coli K-12); hypothetical protein 1311174 912887 ECs1253 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309280.2 1310680 R 386585 CDS NP_309281.1 15830508 912803 complement(1311185..1311775) 1 NC_002695.1 similar to B1008_ECOLI gi|1787243 (conserved in Escherichia coli K-12); hypothetical protein 1311775 912803 ECs1254 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309281.1 1311185 R 386585 CDS NP_309282.1 15830509 912509 complement(1311785..1312585) 1 NC_002695.1 similar to B1009_ECOLI gi|1787244 (conserved in Escherichia coli K-12); acetyltransferase 1312585 912509 ECs1255 Escherichia coli O157:H7 str. Sakai acetyltransferase NP_309282.1 1311785 R 386585 CDS NP_309283.1 15830510 912826 complement(1312593..1312979) 1 NC_002695.1 similar to B1010_ECOLI gi|1787245 (conserved in Escherichia coli K-12); hypothetical protein 1312979 912826 ECs1256 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309283.1 1312593 R 386585 CDS NP_309284.2 38703918 912521 complement(1312991..1313686) 1 NC_002695.1 similar to B1011_ECOLI gi|1787246 (conserved in Escherichia coli K-12); synthetase 1313686 912521 ECs1257 Escherichia coli O157:H7 str. Sakai synthetase NP_309284.2 1312991 R 386585 CDS NP_309285.2 38703919 913968 complement(1313683..1314777) 1 NC_002695.1 similar to B1012_ECOLI gi|1787247 (conserved in Escherichia coli K-12); hypothetical protein 1314777 913968 ECs1258 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309285.2 1313683 R 386585 CDS NP_309286.1 15830513 912884 1315062..1315700 1 NC_002695.1 similar to YCDC_ECOLI gi|1787249 (conserved in Escherichia coli K-12); tet operon regulator 1315700 912884 ECs1259 Escherichia coli O157:H7 str. Sakai tet operon regulator NP_309286.1 1315062 D 386585 CDS NP_309287.1 15830514 912875 complement(1315740..1319702) 1 NC_002695.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1319702 putA 912875 putA Escherichia coli O157:H7 str. Sakai trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase NP_309287.1 1315740 R 386585 CDS NP_944514.1 38703920 2693795 1319757..1319966 1 NC_002695.1 hypothetical protein 1319966 2693795 ECs5411 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944514.1 1319757 D 386585 CDS NP_309288.1 15830515 913007 1320125..1321633 1 NC_002695.1 similar to PUTP_ECOLI gi|1787251 (conserved in Escherichia coli K-12); major sodium/proline symporter 1321633 913007 ECs1261 Escherichia coli O157:H7 str. Sakai major sodium/proline symporter NP_309288.1 1320125 D 386585 CDS NP_309289.1 15830516 912603 complement(1321782..1323125) 1 NC_002695.1 hypothetical protein 1323125 912603 ECs1262 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309289.1 1321782 R 386585 CDS NP_309290.1 15830517 912835 1324307..1325137 1 NC_002695.1 similar to B1016_ECOLI gi|1787252, B1017_ECOLI gi|1787253; cytochrome 1325137 912835 ECs1263 Escherichia coli O157:H7 str. Sakai cytochrome NP_309290.1 1324307 D 386585 CDS NP_309291.1 15830518 913843 1325195..1326322 1 NC_002695.1 similar to YCDO_ECOLI gi|1787254 (conserved in Escherichia coli K-12); hypothetical protein 1326322 913843 ECs1264 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309291.1 1325195 D 386585 CDS NP_309292.1 15830519 912778 1326328..1327599 1 NC_002695.1 similar to YCDB_ECOLI gi|1787255 (conserved in Escherichia coli K-12); hypothetical protein 1327599 912778 ECs1265 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309292.1 1326328 D 386585 CDS NP_309293.1 15830520 912858 1327943..1329007 1 NC_002695.1 ATP-binding pho regulon component; similar to PHOH_ECOLI gi|1787257 (conserved in Escherichia coli K-12); hypothetical protein 1329007 912858 ECs1266 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309293.1 1327943 D 386585 CDS NP_309294.1 15830521 912758 complement(1329057..1329470) 1 NC_002695.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein 1329470 pgaD 912758 pgaD Escherichia coli O157:H7 str. Sakai PGA biosynthesis protein NP_309294.1 1329057 R 386585 CDS NP_309295.1 15830522 912769 complement(1329472..1330797) 1 NC_002695.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 1330797 912769 ECs1268 Escherichia coli O157:H7 str. Sakai N-glycosyltransferase NP_309295.1 1329472 R 386585 CDS NP_309296.1 15830523 912831 complement(1330790..1332808) 1 NC_002695.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase 1332808 pgaB 912831 pgaB Escherichia coli O157:H7 str. Sakai outer membrane N-deacetylase NP_309296.1 1330790 R 386585 CDS NP_309297.1 15830524 912850 complement(1332817..1335240) 1 NC_002695.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA 1335240 pgaA 912850 pgaA Escherichia coli O157:H7 str. Sakai outer membrane protein PgaA NP_309297.1 1332817 R 386585 CDS NP_309298.1 15830525 912861 1335827..1337185 1 NC_002695.1 similar to YCDT_ECOLI gi|1787262 (conserved in Escherichia coli K-12); hypothetical protein 1337185 912861 ECs1271 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309298.1 1335827 D 386585 CDS NP_309299.1 15830526 912750 1337361..1338893 1 NC_002695.1 may confer resistance to phages N4 and lambda; similar to Rtn membrane associated protein [Escherichia coli]gi|2498867|sp|P76446|RTN_ECOLI; rtn-like protein 1338893 912750 ECs1272 Escherichia coli O157:H7 str. Sakai rtn-like protein NP_309299.1 1337361 D 386585 CDS NP_309300.1 15830527 912797 complement(1338995..1339486) 1 NC_002695.1 similar to FidL -Salmonella typhimurium gi|4324611|gb|AAD16955.1; FidL-like protein 1339486 912797 ECs1273 Escherichia coli O157:H7 str. Sakai FidL-like protein NP_309300.1 1338995 R 386585 CDS NP_309301.1 15830528 912774 complement(1339491..1340303) 1 NC_002695.1 similar to transcriptional activators e.g. MarT [Salmonella typhimurium] gi|4324612|gb|AAD16956.1; transcriptional regulator 1340303 912774 ECs1274 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_309301.1 1339491 R 386585 CDS NP_309302.2 38703921 912743 1340991..1341773 1 NC_002695.1 similar to oxidoreductases e.g. [Escherichia coli] gi|2492762|sp|P76633|YGCW_ECOLI; oxidoreductase 1341773 912743 ECs1275 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_309302.2 1340991 D 386585 CDS NP_309303.1 15830530 912817 complement(1341919..1342548) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF60 [Yersinia pestis] gi|7467334|pir||T17432, chaperone proteins e.g. EcpD [Escherichia coli] gi|2506408|sp|P33128|ECPD_ECOLI; chaperone protein 1342548 912817 ECs1276 Escherichia coli O157:H7 str. Sakai chaperone protein NP_309303.1 1341919 R 386585 CDS NP_309304.1 15830531 912506 complement(1342605..1343939) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF59 [Yersinia pestis] gi|4106627|emb|CAA21382.1; outer membrane protein 1343939 912506 ECs1277 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309304.1 1342605 R 386585 CDS NP_309305.1 15830532 912793 complement(1343955..1346477) 1 NC_002695.1 similar to hypothetical protein ORF 58 [Yersinia pestis] gi|4106626|emb|CAA21381.1, outer membrane usher proteins e.g. FimD [Salmonella typhimurium gi|585135|sp|P3792; outer membrane usher protein 1346477 912793 ECs1278 Escherichia coli O157:H7 str. Sakai outer membrane usher protein NP_309305.1 1343955 R 386585 CDS NP_309306.2 38703922 912756 complement(1346530..1347252) 1 NC_002695.1 similar to hypothetical protein ORF57 [Yersinia pestis] gi|4106625|emb|CAA21380.1, chaperone proteins e.g. EcpD [Escherichia coli] gi|2506408|sp|P33128|ECPD_ECOLI; chaperone protein 1347252 912756 ECs1279 Escherichia coli O157:H7 str. Sakai chaperone protein NP_309306.2 1346530 R 386585 CDS NP_309307.1 15830534 912615 complement(1347317..1347877) 1 NC_002695.1 similar to hypothetical protein ORF56 [Yersinia pestis] gi|4106624|emb|CAA21379.1, major pilin proteins e.g. SfaA [Escherichia coli] gi|4105989|gb|AAD02646.1; major pilin protein 1347877 912615 ECs1280 Escherichia coli O157:H7 str. Sakai major pilin protein NP_309307.1 1347317 R 386585 CDS NP_309308.1 15830535 912939 complement(1347920..1348543) 1 NC_002695.1 hypothetical protein 1348543 912939 ECs1281 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309308.1 1347920 R 386585 CDS NP_309309.1 15830536 912619 1349940..1353746 1 NC_002695.1 similar to hemagglutinin/hemolysin-related proteins [Neisseria meningitidis] e.g. gi|7225719|gb|AAF40927.1; hemagglutinin/hemolysin-like protein 1353746 912619 ECs1282 Escherichia coli O157:H7 str. Sakai hemagglutinin/hemolysin-like protein NP_309309.1 1349940 D 386585 CDS NP_309310.1 15830537 912949 1353835..1355454 1 NC_002695.1 similar to hemolysin activator-related proteins e.g. [Pectobacterium chrysanthemi] gi|1772622|gb|AAC31980.1; hemolysin activator-like protein 1355454 912949 ECs1283 Escherichia coli O157:H7 str. Sakai hemolysin activator-like protein NP_309310.1 1353835 D 386585 CDS NP_309311.1 15830538 912725 1355470..1355838 1 NC_002695.1 similar to holo-[acyl-carrier protein] synthases e.g. [Campylobacter jejuni] gi|6968838|emb|CAB73833.1; holo-ACP synthase 1355838 912725 ECs1284 Escherichia coli O157:H7 str. Sakai holo-ACP synthase NP_309311.1 1355470 D 386585 CDS NP_309312.1 15830539 912978 1356044..1356613 1 NC_002695.1 similar to 3-oxoacyl-(acyl carrier protein) reductases e.g. [Moritella marina] gi|7227179|gb|AAF42251.1; 3-oxoacyl-ACP reductase 1356613 912978 ECs1285 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP reductase NP_309312.1 1356044 D 386585 CDS NP_309313.1 15830540 912983 1356617..1357165 1 NC_002695.1 similar to (3R)-hydroxymyristol-(acyl carrier protein) dehydratases e.g. gi|7190847|gb|AAF39621.1; (3R)-hydroxymyristoyl-ACP dehydratase 1357165 912983 ECs1286 Escherichia coli O157:H7 str. Sakai (3R)-hydroxymyristoyl-ACP dehydratase NP_309313.1 1356617 D 386585 CDS NP_309314.2 38703923 913514 1357196..1357468 1 NC_002695.1 similar to acyl carrier proteins e.g. AcpC [Streptococcus agalactiae] gi|4886773|gb|AAD32036.1|AF093787_4; acyl carrier protein 1357468 913514 ECs1287 Escherichia coli O157:H7 str. Sakai acyl carrier protein NP_309314.2 1357196 D 386585 CDS NP_309315.1 15830542 912944 1357504..1358664 1 NC_002695.1 similar to aminpometyl transferases e.g. gi|7450600|pir||C75088; glycine cleavage system protein T 1358664 912944 ECs1288 Escherichia coli O157:H7 str. Sakai glycine cleavage system protein T NP_309315.1 1357504 D 386585 CDS NP_309316.1 15830543 912824 1358738..1361296 1 NC_002695.1 similar to 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41) [Bacillus subtilis] gi|7433750|pir||G69842; 3-oxoacyl-ACP synthase 1361296 912824 ECs1289 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP synthase NP_309316.1 1358738 D 386585 CDS NP_309317.1 15830544 912578 1361544..1362524 1 NC_002695.1 similar to polyketide synthases e.g. [Streptomyces sp. strain MA6548] gi|7481905|pir||T17428; hypothetical protein 1362524 912578 ECs1290 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309317.1 1361544 D 386585 CDS NP_309318.1 15830545 912942 1362623..1363474 1 NC_002695.1 hypothetical protein 1363474 912942 ECs1291 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309318.1 1362623 D 386585 CDS NP_309319.1 15830546 912975 1363485..1364192 1 NC_002695.1 similar to ABC transporters (ATP binding proteins) e.g. [Thermotoga maritima] gi|7445988|pir||H72342; ABC transporter ATP-binding protein 1364192 912975 ECs1292 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_309319.1 1363485 D 386585 CDS NP_309320.1 15830547 912977 1364176..1364832 1 NC_002695.1 hypothetical protein 1364832 912977 ECs1293 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309320.1 1364176 D 386585 CDS NP_309321.1 15830548 912523 1364833..1366143 1 NC_002695.1 similar to hypothetical proteins e.g. BBJ27 [Lyme disease spirochete plasmid J/lp38] gi|7463605|pir||D70248; hypothetical protein 1366143 912523 ECs1294 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309321.1 1364833 D 386585 CDS NP_309322.1 15830549 916336 1366152..1366940 1 NC_002695.1 hypothetical protein 1366940 916336 ECs1295 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309322.1 1366152 D 386585 CDS NP_309323.1 15830550 912551 1366937..1368325 1 NC_002695.1 hypothetical protein 1368325 912551 ECs1296 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309323.1 1366937 D 386585 CDS NP_309324.1 15830551 914017 1368957..1369280 1 NC_002695.1 similar to B1028_ECOLI gi|1787266 (conserved in Escherichia coli K-12); hypothetical protein 1369280 914017 ECs1297 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309324.1 1368957 D 386585 CDS NP_309325.1 15830552 912971 1369277..1370263 1 NC_002695.1 similar to YCDU_ECOLI gi|1787267 (conserved in Escherichia coli K-12); hypothetical protein 1370263 912971 ECs1298 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309325.1 1369277 D 386585 CDS NP_309326.1 15830553 912968 1370630..1371832 1 NC_002695.1 similar to integrases e.g. [Vibrio cholerae] gi|498253|gb|AAC44230.1|; integrase 1371832 912968 ECs1299 Escherichia coli O157:H7 str. Sakai integrase NP_309326.1 1370630 D 386585 CDS NP_309327.1 15830554 912838 complement(1372019..1373836) 1 NC_002695.1 similar to hemagglutinin main component [Clostridium botulinum phage (type C)] gi|1346254|sp|P46084|HA33_CLOBO; hypothetical protein 1373836 912838 ECs1300 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309327.1 1372019 R 386585 CDS NP_309328.1 15830555 915171 1374332..1374769 1 NC_002695.1 similar to InsB proteins e.g. [Shigella dysenteriae Iso-IS1] gi|6759959|gb|AAF28117.1|AF153317_13; transposase 1374769 915171 ECs1301 Escherichia coli O157:H7 str. Sakai transposase NP_309328.1 1374332 D 386585 CDS NP_309329.1 15830556 912895 1374948..1375244 1 NC_002695.1 similar to prophage cp4-57 regulatory protein AlpA [Escherichia coli (strain K-12)] gi|461502|sp|P33997|ALPA_ECOLI; regulatory protein 1375244 912895 ECs1302 Escherichia coli O157:H7 str. Sakai regulatory protein NP_309329.1 1374948 D 386585 CDS NP_944515.1 38703924 2693745 1375471..1375668 1 NC_002695.1 hypothetical protein 1375668 2693745 ECs5412 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944515.1 1375471 D 386585 CDS NP_309330.1 15830557 913048 1375887..1377272 1 NC_002695.1 similar to hypothetical protein b2625 (YfjI) [Escherichia coli K-12] gi|1723621|sp|P52124|YFJI_ECOLI; hypothetical protein 1377272 913048 ECs1303 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309330.1 1375887 D 386585 CDS NP_309331.1 15830558 915173 1378093..1378656 1 NC_002695.1 similar to hypothetical protein Cj1244 [Campylobacter jejuni] gi|6968677|emb|CAB73498.1; hypothetical protein 1378656 915173 ECs1304 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309331.1 1378093 D 386585 CDS NP_309332.1 15830559 912859 1378811..1381171 1 NC_002695.1 similar to hypothetical protein A153R [Chlorella virus PBCV-1] gi|7461298|pir||T17644, DNA repair protein rad25 PAB0128 [Pyrococcus abyssi (strain Orsay)] gi|7514780|pir||A75209; hypothetical protein 1381171 912859 ECs1305 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309332.1 1378811 D 386585 CDS NP_309334.1 15830561 914163 complement(1381928..1383466) 1 NC_002695.1 similar to L0015 [Escherichia coli] gi|3414883|gb|AAC31494.1 and hypothetical protein [Escherichia coli] gi|3288156|emb|CAA11509.1; hypothetical protein 1383466 914163 ECs1307 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309334.1 1381928 R 386585 CDS NP_309335.1 15830562 913484 complement(1383516..1383863) 1 NC_002695.1 similar to L0014 [Escherichia coli] gi|3288157|emb|CAA11510.1 and hypothetical proteins e.g. orf50 [Escherichia coli] gi|6009426|dbj|BAA84885.1; hypothetical protein 1383863 913484 ECs1308 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309335.1 1383516 R 386585 CDS NP_309336.1 15830563 913697 complement(1383860..1384261) 1 NC_002695.1 similar to hypothetical proteins e.g. L0013 [Escherichia coli] gi|3414881|gb|AAC31492.1|; hypothetical protein 1384261 913697 ECs1309 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309336.1 1383860 R 386585 CDS NP_309338.1 15830565 912418 1384767..1385585 1 NC_002695.1 similar to transposases e.g. Hp1 [Escherichia coli] gi|3661482|gb|AAC61713.1 and InsB [Shigella dysenteriae] gi|5532467|gb|AAD44751.1|AF141323_22; transposase 1385585 912418 ECs1311 Escherichia coli O157:H7 str. Sakai transposase NP_309338.1 1384767 D 386585 CDS NP_309339.1 15830566 912825 1385491..1386237 1 NC_002695.1 similar to lipoprotein traT precursors e.g. gi|418135|sp|P32885|TRT1_ECOLI; complement resistance protein 1386237 912825 ECs1312 Escherichia coli O157:H7 str. Sakai complement resistance protein NP_309339.1 1385491 D 386585 CDS NP_309342.1 15830569 912370 complement(1386926..1387126) 1 NC_002695.1 hypothetical protein 1387126 912370 ECs1315 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309342.1 1386926 R 386585 CDS NP_309343.1 15830570 912686 1387536..1387895 1 NC_002695.1 similar to diacylglycerol kinases e.g. gi|125321|sp|P00556|KDGL_ECOLI; diacylglycerol kinase 1387895 912686 ECs1316 Escherichia coli O157:H7 str. Sakai diacylglycerol kinase NP_309343.1 1387536 D 386585 CDS NP_309344.1 15830571 913035 complement(1387988..1389274) 1 NC_002695.1 similar to hypothetical proteins e.g. yjdB in basS-adiY intergenic region [Escherichia coli] gi|731986|sp|P30845|YJDB_ECOLI; outer membrane protein 1389274 913035 ECs1317 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309344.1 1387988 R 386585 CDS NP_309346.1 15830573 913342 complement(1389832..1390107) 1 NC_002695.1 hypothetical protein 1390107 913342 ECs1319 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309346.1 1389832 R 386585 CDS NP_309347.1 15830574 912706 complement(1390159..1390362) 1 NC_002695.1 hypothetical protein 1390362 912706 ECs1320 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309347.1 1390159 R 386585 CDS NP_309348.1 15830575 912366 1390443..1391186 1 NC_002695.1 similar to UreD [Klebsiella aerogenes] gi|731078|sp|Q09063|URED_KLEAE; hypothetical protein 1391186 912366 ECs1321 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309348.1 1390443 D 386585 CDS NP_309349.1 15830576 913824 1391277..1391579 1 NC_002695.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1391579 ureA 913824 ureA Escherichia coli O157:H7 str. Sakai urease subunit gamma NP_309349.1 1391277 D 386585 CDS NP_309350.1 15830577 913707 1391588..1391908 1 NC_002695.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1391908 ureB 913707 ureB Escherichia coli O157:H7 str. Sakai urease subunit beta NP_309350.1 1391588 D 386585 CDS NP_309351.1 15830578 913507 1391898..1393604 1 NC_002695.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1393604 ureC 913507 ureC Escherichia coli O157:H7 str. Sakai urease subunit alpha NP_309351.1 1391898 D 386585 CDS NP_309352.1 15830579 913913 1393614..1394078 1 NC_002695.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1394078 ureE 913913 ureE Escherichia coli O157:H7 str. Sakai urease accessory protein UreE NP_309352.1 1393614 D 386585 CDS NP_309353.1 15830580 912425 1394079..1394753 1 NC_002695.1 urease accessory protein; similar to urease accessory proteins UreF e.g. [Klebsiella aerogenes] gi|137097|sp|P18318|UREF_KLEAE; UreF 1394753 912425 ECs1326 Escherichia coli O157:H7 str. Sakai UreF NP_309353.1 1394079 D 386585 CDS NP_309354.1 15830581 912768 1394765..1395382 1 NC_002695.1 urease accessory protein; similar to UreG urease accessory proteins e.g. [Klebsiella aerogenes] gi|137099|sp|P18319|UREG_KLEAE; protein UreG 1395382 912768 ECs1327 Escherichia coli O157:H7 str. Sakai protein UreG NP_309354.1 1394765 D 386585 CDS NP_309355.1 15830582 914200 complement(1395638..1395979) 1 NC_002695.1 similar to TnpJ [Shigella flexneri] gi|5532468|gb|AAD44752.1|AF141323_23; hypothetical protein 1395979 914200 ECs1328 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309355.1 1395638 R 386585 CDS NP_309357.1 15830584 912490 1396594..1396857 1 NC_002695.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1396857 rpmE2 912490 rpmE2 Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L31 NP_309357.1 1396594 D 386585 CDS NP_944516.1 38703925 2693820 1397159..1397299 1 NC_002695.1 hypothetical protein 1397299 2693820 ECs5413 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944516.1 1397159 D 386585 CDS NP_309361.1 15830588 912624 complement(1399045..1399200) 1 NC_002695.1 hypothetical protein 1399200 912624 ECs1334 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309361.1 1399045 R 386585 CDS NP_309362.1 15830589 913845 1399917..1400678 1 NC_002695.1 hypothetical protein 1400678 913845 ECs1335 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309362.1 1399917 D 386585 CDS NP_309363.1 15830590 913780 complement(1400375..1400974) 1 NC_002695.1 similar to hypothetical protein [Pseudomonas putida] gi|2995633|gb|AAC98738.1 and L0015 [Escherichia coli] gi|3414883|gb|AAC31494.1; hypothetical protein 1400974 913780 ECs1336 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309363.1 1400375 R 386585 CDS NP_309364.1 15830591 913904 1401180..1401605 1 NC_002695.1 similar to hypothetical protein orf29 [Escherichia coli] gi|6009405|dbj|BAA84864.1 and L0013 [Escherichia coli] gi|3414881|gb|AAC31492.1; hypothetical protein 1401605 913904 ECs1337 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309364.1 1401180 D 386585 CDS NP_309365.1 15830592 912312 1401602..1401952 1 NC_002695.1 similar to hypothetical protein orf50 [Escherichia coli] gi|6009426|dbj|BAA84885.1 and L0014 [Escherichia coli] gi|3288157|emb|CAA11510.1; hypothetical protein 1401952 912312 ECs1338 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309365.1 1401602 D 386585 CDS NP_309366.1 15830593 913949 1401983..1403596 1 NC_002695.1 similar to hypothetical protein L0015 [Escherichia coli] gi|3414883|gb|AAC31494.1; hypothetical protein 1403596 913949 ECs1339 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309366.1 1401983 D 386585 CDS NP_309367.1 15830594 913578 complement(1403600..1404328) 1 NC_002695.1 similar to hypothetical protein 57.8 kD protein [Pseudomonas putida] gi|2496740|sp|P55630|Y4QI_RHISN; hypothetical protein 1404328 913578 ECs1340 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309367.1 1403600 R 386585 CDS NP_309370.1 15830597 912463 complement(1405457..1405924) 1 NC_002695.1 immunity to R478 phage/colicin/tellurite resistance cluster; similar to TerW [Plasmid R478] gi|1354147|gb|AAC44736.1; TerW protein 1405924 912463 ECs1343 Escherichia coli O157:H7 str. Sakai TerW protein NP_309370.1 1405457 R 386585 CDS NP_309371.1 15830598 913679 complement(1405942..1407150) 1 NC_002695.1 hypothetical protein 1407150 913679 ECs1344 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309371.1 1405942 R 386585 CDS NP_309372.1 15830599 913346 complement(1407161..1408117) 1 NC_002695.1 similar to hypothetical protein [Deinococcus radiodurans] gi|7472167|pir||B75302; hypothetical protein 1408117 913346 ECs1345 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309372.1 1407161 R 386585 CDS NP_309373.1 15830600 913265 complement(1408117..1408851) 1 NC_002695.1 similar to hypothetical protein [Streptomyces coelicolor A3(2)] gi|7472048|pir||A75302; hypothetical protein 1408851 913265 ECs1346 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309373.1 1408117 R 386585 CDS NP_309374.1 15830601 913886 complement(1408853..1409233) 1 NC_002695.1 similar to hypothetical protein [Streptomyces coelicolor A3(2)] gi|8246803|emb|CAB92838.1; hypothetical protein 1409233 913886 ECs1347 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309374.1 1408853 R 386585 CDS NP_309375.1 15830602 912882 complement(1409199..1409972) 1 NC_002695.1 similar to hypothetical protein [Serratia marcescens] gi|1695868|gb|AAB37122.1; hypothetical protein 1409972 912882 ECs1348 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309375.1 1409199 R 386585 CDS NP_309376.1 15830603 912691 complement(1409965..1411107) 1 NC_002695.1 similar to hypothetical protein [Serratia marcescens] gi|1695869|gb|AAB37123.1, [Deinococcus radiodurans (strain R1)] gi|7471591|pir||F75301; hypothetical protein 1411107 912691 ECs1349 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309376.1 1409965 R 386585 CDS NP_309377.1 15830604 913123 complement(1411117..1412175) 1 NC_002695.1 similar to hypothetical protein [Serratia marcescens] gi|1695870|gb|AAB37124.1, [Serratia marcescens] gi|1695871|gb|AAB37125.1, [Deinococcus radiodurans] gi|7471522|pir||E7530; hypothetical protein 1412175 913123 ECs1350 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309377.1 1411117 R 386585 CDS NP_309378.1 15830605 912773 1412498..1413079 1 NC_002695.1 tellurium resistance protein; similar to TerZ protein [Serratia marcescens] gi|6094454|sp|Q52353; protein TerZ 1413079 912773 ECs1351 Escherichia coli O157:H7 str. Sakai protein TerZ NP_309378.1 1412498 D 386585 CDS NP_309379.1 15830606 912536 1413211..1414236 1 NC_002695.1 tellurium resistance protein; similar to TerA protein [Serratia marcescens] gi|5702379|gb|AAD47285.1|AF168355_3; protein TerA 1414236 912536 ECs1352 Escherichia coli O157:H7 str. Sakai protein TerA NP_309379.1 1413211 D 386585 CDS NP_309380.1 15830607 913092 1414259..1414714 1 NC_002695.1 tellurium resistance protein; similar to TerB protein [Serratia marcescens] gi|950680|gb|AAA86848.1; protein TerB 1414714 913092 ECs1353 Escherichia coli O157:H7 str. Sakai protein TerB NP_309380.1 1414259 D 386585 CDS NP_309381.1 15830608 913363 1414737..1415777 1 NC_002695.1 tellurium resistance protein; similar to TerC protein [Serratia marcescens] gi|6226214|sp|Q52356|TERC_SERMA; protein TerC 1415777 913363 ECs1354 Escherichia coli O157:H7 str. Sakai protein TerC NP_309381.1 1414737 D 386585 CDS NP_309382.1 15830609 912680 1415826..1416404 1 NC_002695.1 tellurium resistance protein; similar to terD proteins e.g. [Serratia marcescens] gi|6094448|sp|Q52357|TERD_SERMA; protein TerD 1416404 912680 ECs1355 Escherichia coli O157:H7 str. Sakai protein TerD NP_309382.1 1415826 D 386585 CDS NP_309383.1 15830610 912662 1416473..1417048 1 NC_002695.1 tellurium resistance protein; similar to gi|7108482|gb|AAF36434.1|AF126104_3 TLRB_ECOLI, TerE [Serratia marcescens] gi|6094449|sp|Q52358|TERE_SERMA; protein TerE 1417048 912662 ECs1356 Escherichia coli O157:H7 str. Sakai protein TerE NP_309383.1 1416473 D 386585 CDS NP_309384.1 15830611 912343 1417073..1417276 1 NC_002695.1 hypothetical protein 1417276 912343 ECs1357 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309384.1 1417073 D 386585 CDS NP_309386.1 15830613 912576 complement(1417912..1418136) 1 NC_002695.1 hypothetical protein 1418136 912576 ECs1359 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309386.1 1417912 R 386585 CDS NP_309387.1 15830614 912400 complement(1418370..1420460) 1 NC_002695.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 1420460 912400 ECs1360 Escherichia coli O157:H7 str. Sakai bifunctional enterobactin receptor/adhesin protein NP_309387.1 1418370 R 386585 CDS NP_309389.1 15830616 913263 1421859..1422131 1 NC_002695.1 similar to ShiA [Shigella flexneri] gi|5532447|gb|AAD44731.1|AF141323_2; hypothetical protein 1422131 913263 ECs1362 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309389.1 1421859 D 386585 CDS NP_309391.1 15830618 912639 complement(1423880..1424074) 1 NC_002695.1 hypothetical protein 1424074 912639 ECs1364 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309391.1 1423880 R 386585 CDS NP_309392.1 15830619 912311 1424154..1424378 1 NC_002695.1 hypothetical protein 1424378 912311 ECs1365 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309392.1 1424154 D 386585 CDS NP_309393.1 15830620 916558 1424394..1424666 1 NC_002695.1 hypothetical protein 1424666 916558 ECs1366 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309393.1 1424394 D 386585 CDS NP_309394.1 15830621 915289 1424971..1425165 1 NC_002695.1 hypothetical protein 1425165 915289 ECs1367 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309394.1 1424971 D 386585 CDS NP_944517.1 38703926 2693821 1425231..1425428 1 NC_002695.1 hypothetical protein 1425428 2693821 ECs5414 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944517.1 1425231 D 386585 CDS NP_309397.1 15830624 912409 1426158..1427282 1 NC_002695.1 similar to glucosyl-transferases [Salmonella typhi] gi|7467230|pir||T30292; glucosyl-transferase 1427282 912409 ECs1370 Escherichia coli O157:H7 str. Sakai glucosyl-transferase NP_309397.1 1426158 D 386585 CDS NP_309399.1 15830626 914906 complement(1427701..1428204) 1 NC_002695.1 similar to transposases e.g. [Shigella boydii] gi|2197010|gb|AAB61273.1; transposase 1428204 914906 ECs1372 Escherichia coli O157:H7 str. Sakai transposase NP_309399.1 1427701 R 386585 CDS NP_309400.1 15830627 912500 complement(1428123..1428398) 1 NC_002695.1 repressor; similar to InsA proteins e.g. [insertion sequence IS1F] gi|124915|sp|P19767|ISA2_ECOLI; hypothetical protein 1428398 912500 ECs1373 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309400.1 1428123 R 386585 CDS NP_309401.1 15830628 913813 complement(1428636..1429094) 1 NC_002695.1 hypothetical protein 1429094 913813 ECs1374 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309401.1 1428636 R 386585 CDS NP_309402.1 15830629 914866 1429159..1429350 1 NC_002695.1 hypothetical protein 1429350 914866 ECs1375 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309402.1 1429159 D 386585 CDS NP_309403.1 15830630 912401 1429552..1430061 1 NC_002695.1 hypothetical protein 1430061 912401 ECs1376 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309403.1 1429552 D 386585 CDS NP_309404.1 15830631 915129 1430150..1430773 1 NC_002695.1 similar to sensor-regulator protein HutT [Rhodobacter capsulatus] gi|1075537|pir||A49938; hypothetical protein 1430773 915129 ECs1377 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309404.1 1430150 D 386585 CDS NP_309405.1 15830632 913726 1430869..1431102 1 NC_002695.1 hypothetical protein 1431102 913726 ECs1378 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309405.1 1430869 D 386585 CDS NP_309406.1 15830633 913994 1431113..1431328 1 NC_002695.1 hypothetical protein 1431328 913994 ECs1379 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309406.1 1431113 D 386585 CDS NP_944518.1 38703927 2693822 complement(1431155..1431346) 1 NC_002695.1 hypothetical protein 1431346 2693822 ECs5415 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944518.1 1431155 R 386585 CDS NP_309407.1 15830634 914090 complement(1431940..1432827) 1 NC_002695.1 OrfB; similar to transposase [insertion sequenceIS629] gi|7443863|pir||T00315; transposase 1432827 914090 ECs1380 Escherichia coli O157:H7 str. Sakai transposase NP_309407.1 1431940 R 386585 CDS NP_309408.1 15830635 912467 complement(1432827..1433153) 1 NC_002695.1 OrfA; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 1433153 912467 ECs1381 Escherichia coli O157:H7 str. Sakai transposase NP_309408.1 1432827 R 386585 CDS NP_309409.1 15830636 912541 1433646..1434380 1 NC_002695.1 similar to hemolysin activation protein HecB [Neisseria meningitidis MC58] gi|7227016|gb|AAF42103.1; HecB-like protein 1434380 912541 ECs1382 Escherichia coli O157:H7 str. Sakai HecB-like protein NP_309409.1 1433646 D 386585 CDS NP_309413.1 15830640 912382 1437802..1439034 1 NC_002695.1 similar to hypothetical protein YbdN [Escherichia coli] gi|3024984|sp|P77216|YBDN_ECOLI; hypothetical protein 1439034 912382 ECs1386 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309413.1 1437802 D 386585 CDS NP_309414.1 15830641 913299 1439019..1439657 1 NC_002695.1 similar to hypothetical protein YbdM [Escherichia coli] gi|3024983|sp|P77174|YBDM_ECOLI; hypothetical protein 1439657 913299 ECs1387 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309414.1 1439019 D 386585 CDS NP_309415.1 15830642 913436 1439736..1440005 1 NC_002695.1 similar to PerC (BfpW) [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional regulator 1440005 913436 ECs1388 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_309415.1 1439736 D 386585 CDS NP_309416.1 15830643 912545 1440026..1440670 1 NC_002695.1 similar to exopolyphosphatase [Pseudomonas aeruginosa] gi|4200042|dbj|BAA74460.1; hypothetical protein 1440670 912545 ECs1389 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309416.1 1440026 D 386585 CDS NP_309419.1 15830646 913190 1441434..1441655 1 NC_002695.1 similar to hypothetical protein [Pseudomonas syringae] gi|1196744|gb|AAA88435; hypothetical protein 1441655 913190 ECs1392 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309419.1 1441434 D 386585 CDS NP_309420.1 15830647 913807 1441670..1442095 1 NC_002695.1 similar to hypothetical protein orf29 [Escherichia coli] gi|6009405|dbj|BAA84864.1, L0013 [Escherichia coli] gi|3414881|gb|AAC31492.1; hypothetical protein 1442095 913807 ECs1393 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309420.1 1441670 D 386585 CDS NP_309421.1 15830648 914450 complement(1442395..1442577) 1 NC_002695.1 hypothetical protein 1442577 914450 ECs1394 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309421.1 1442395 R 386585 CDS NP_309422.1 15830649 914784 1442906..1443778 1 NC_002695.1 similar to hypothetical proteins e.g. yfjP protein [Escherichia coli] gi|7449539|pir||B65042, YeeP [Escherichia coli] gi|2495624|sp|P76359|YEEP_ECOLI; hypothetical protein 1443778 914784 ECs1395 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309422.1 1442906 D 386585 CDS NP_309423.1 15830650 912599 1444150..1446999 1 NC_002695.1 similar to adhesin AIDA-I precursor [Escherichia coli plasmid pIB6] gi|543788|sp|Q03155|AIDA_ECOLI, glycoprotein [Escherichia coli strain H10407] gi|5305639|gb|AAD41751.1, outer membrane fluffing protein [Escherichia coli] gi|7466262|pir||G64964; adhesin-like protein; AidA-I 1446999 912599 ECs1396 Escherichia coli O157:H7 str. Sakai AidA-I NP_309423.1 1444150 D 386585 CDS NP_309424.1 15830651 912553 1447110..1449494 1 NC_002695.1 similar to hypothetical protein YjDA [Escherichia coli] gi|731985|sp|P16694|YJDA_ECOLI; hypothetical protein 1449494 912553 ECs1397 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309424.1 1447110 D 386585 CDS NP_309425.1 15830652 912390 1449491..1450396 1 NC_002695.1 similar to hypothetical protein YjcZ [Escherichia coli] gi|731984|sp|P39267|YJCZ_ECOLI; hypothetical protein 1450396 912390 ECs1398 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309425.1 1449491 D 386585 CDS NP_309426.1 15830653 913466 1450393..1451463 1 NC_002695.1 hypothetical protein 1451463 913466 ECs1399 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309426.1 1450393 D 386585 CDS NP_309427.1 15830654 912753 complement(1451568..1451732) 1 NC_002695.1 hypothetical protein 1451732 912753 ECs1400 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309427.1 1451568 R 386585 CDS NP_309428.1 15830655 914069 1451803..1452621 1 NC_002695.1 similar to hypothetical protein YfjQ [Escherichia coli] gi|1723629|sp|P52132|YFJQ_ECOLI, YafZ [Escherichia coli] gi|2495487|sp|P77206|YAFZ_ECOLI; hypothetical protein 1452621 914069 ECs1401 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309428.1 1451803 D 386585 CDS NP_309429.1 15830656 913948 1452712..1453197 1 NC_002695.1 similar to hypothetical protein YafK [Escherichia coli] gi|2495486|sp|P75676|YAFX_ECOLI, YfjX [Escherichia coli] gi|1723636|sp|P52139|YFJX_ECOLI; hypothetical protein 1453197 913948 ECs1402 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309429.1 1452712 D 386585 CDS NP_309430.1 15830657 912368 1453213..1453689 1 NC_002695.1 probable DNA repair protein (RadC family), similar to RadC family protein YkfG [Escherichia coli] gi|3025218|sp|Q47685|YKFG_ECOLI, YeeS [Escherichia coli] gi|3025155|sp|P76362|YEES_ECOLI; DNA repair protein 1453689 912368 ECs1403 Escherichia coli O157:H7 str. Sakai DNA repair protein NP_309430.1 1453213 D 386585 CDS NP_309431.1 15830658 912387 1453752..1453973 1 NC_002695.1 similar to hypothetical protein YeeT [Escherichia coli] gi|3025156|sp|P76363|YEET_ECOLI; hypothetical protein 1453973 912387 ECs1404 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309431.1 1453752 D 386585 CDS NP_309432.1 15830659 914193 1454136..1454510 1 NC_002695.1 similar to hypothetical protein YeeU [Escherichia coli] gi|3025157|sp|P76364|YEEU_ECOLI, YfjZ [Escherichia coli] gi|1723638|sp|P52141|YFJZ_ECOLI; hypothetical protein 1454510 914193 ECs1405 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309432.1 1454136 D 386585 CDS NP_309433.1 15830660 912823 1454557..1454931 1 NC_002695.1 similar to hypothetical protein L0007 [Escherichia coli] gi|3414875|gb|AAC31486.1, YeeV [Escherichia coli] gi|3025158|sp|P76365|YEEV_ECOLI, YkfI [Escherichia coli] gi|3025213|s; hypothetical protein 1454931 912823 ECs1406 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309433.1 1454557 D 386585 CDS NP_309434.1 15830661 912406 1454928..1455419 1 NC_002695.1 similar to hypothetical protein L0008 [Escherichia coli] gi|3414876|gb|AAC31487.1, YeeW [Escherichia coli] gi|3025160|sp|P76366|YEEW_ECOLI; hypothetical protein 1455419 912406 ECs1407 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309434.1 1454928 D 386585 CDS NP_309435.1 15830662 912560 1455431..1455628 1 NC_002695.1 similar to hypothetical protein L0009 [Escherichia coli] gi|3414877|gb|AAC31488.1; hypothetical protein 1455628 912560 ECs1408 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309435.1 1455431 D 386585 CDS NP_309436.1 15830663 912327 1455713..1456555 1 NC_002695.1 similar to hypothetical protein L0010 [Escherichia coli] gi|3414878|gb|AAC31489.1, ydiA [Plasmid ColIb-P9] gi|4512489|dbj|BAA75138.1, L0012 [Escherichia coli] gi|3414880|gb|A; hypothetical protein 1456555 912327 ECs1409 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309436.1 1455713 D 386585 CDS NP_309437.1 15830664 914357 1456987..1457964 1 NC_002695.1 similar to YCDW_ECOLI gi|1787270 (conserved in Escherichia coli K-12); dehydrogenase 1457964 914357 ECs1410 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_309437.1 1456987 D 386585 CDS NP_309438.1 15830665 912538 1458019..1458756 1 NC_002695.1 similar to YCDX_ECOLI gi|1787271 (conserved in Escherichia coli K-12); hydrolase 1458756 912538 ECs1411 Escherichia coli O157:H7 str. Sakai hydrolase NP_309438.1 1458019 D 386585 CDS NP_309439.1 15830666 912375 1458780..1459334 1 NC_002695.1 similar to YCDY_ECOLI gi|1787272 (conserved in Escherichia coli K-12); oxidoreductase component 1459334 912375 ECs1412 Escherichia coli O157:H7 str. Sakai oxidoreductase component NP_309439.1 1458780 D 386585 CDS NP_309440.2 38703928 914162 1459406..1459927 1 NC_002695.1 similar to YCDZ_ECOLI gi|1787273 (conserved in Escherichia coli K-12); hypothetical protein 1459927 914162 ECs1413 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309440.2 1459406 D 386585 CDS NP_309441.1 15830668 914144 complement(1459991..1460824) 1 NC_002695.1 curli production assembly/transport component; similar to CSGG_ECOLI gi|1787274 (conserved in Escherichia coli K-12); protein CsgG 1460824 914144 ECs1414 Escherichia coli O157:H7 str. Sakai protein CsgG NP_309441.1 1459991 R 386585 CDS NP_309442.1 15830669 913765 complement(1460851..1461267) 1 NC_002695.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1461267 913765 ECs1415 Escherichia coli O157:H7 str. Sakai curli assembly protein CsgF NP_309442.1 1460851 R 386585 CDS NP_309443.1 15830670 912466 complement(1461292..1461681) 1 NC_002695.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1461681 912466 ECs1416 Escherichia coli O157:H7 str. Sakai curli assembly protein CsgE NP_309443.1 1461292 R 386585 CDS NP_309444.1 15830671 913469 complement(1461686..1462336) 1 NC_002695.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1462336 913469 ECs1417 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator CsgD NP_309444.1 1461686 R 386585 CDS NP_309445.1 15830672 913642 complement(1462748..1462987) 1 NC_002695.1 hypothetical protein 1462987 913642 ECs1418 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309445.1 1462748 R 386585 CDS NP_309446.1 15830673 912479 1463090..1463545 1 NC_002695.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1463545 912479 ECs1419 Escherichia coli O157:H7 str. Sakai curlin minor subunit NP_309446.1 1463090 D 386585 CDS NP_309447.1 15830674 913991 1463586..1464044 1 NC_002695.1 similar to CSGA_ECOLI gi|1787279 (conserved in Escherichia coli K-12); cryptic curlin major subunit 1464044 913991 ECs1420 Escherichia coli O157:H7 str. Sakai cryptic curlin major subunit NP_309447.1 1463586 D 386585 CDS NP_309448.1 15830675 912415 1464103..1464435 1 NC_002695.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1464435 csgC 912415 csgC Escherichia coli O157:H7 str. Sakai autoagglutination protein NP_309448.1 1464103 D 386585 CDS NP_309449.1 15830676 912307 1464556..1464867 1 NC_002695.1 similar to B1044_ECOLI gi|1787281 (conserved in Escherichia coli K-12); hypothetical protein 1464867 912307 ECs1422 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309449.1 1464556 D 386585 CDS NP_309450.1 15830677 912957 1464962..1465495 1 NC_002695.1 similar to B1045_ECOLI gi|1787283 (conserved in Escherichia coli K-12); hypothetical protein 1465495 912957 ECs1423 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309450.1 1464962 D 386585 CDS NP_309451.1 15830678 912591 1465437..1466918 1 NC_002695.1 similar to YMDC_ECOLI gi|1787284 (conserved in Escherichia coli K-12); synthase 1466918 912591 ECs1424 Escherichia coli O157:H7 str. Sakai synthase NP_309451.1 1465437 D 386585 CDS NP_309452.1 15830679 914215 complement(1466926..1468083) 1 NC_002695.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1468083 mdoC 914215 mdoC Escherichia coli O157:H7 str. Sakai glucans biosynthesis protein NP_309452.1 1466926 R 386585 CDS NP_309453.1 15830680 912482 1468476..1470011 1 NC_002695.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1470011 mdoG 912482 mdoG Escherichia coli O157:H7 str. Sakai glucan biosynthesis protein G NP_309453.1 1468476 D 386585 CDS NP_309454.1 15830681 913619 1469974..1472547 1 NC_002695.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1472547 913619 ECs1427 Escherichia coli O157:H7 str. Sakai glucosyltransferase MdoH NP_309454.1 1469974 D 386585 CDS NP_309455.1 15830682 912402 1472720..1472947 1 NC_002695.1 similar to YCEK_ECOLI gi|1787288 (conserved in Escherichia coli K-12); hypothetical protein 1472947 912402 ECs1428 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309455.1 1472720 D 386585 CDS NP_309456.2 38703929 914483 complement(1472948..1473322) 1 NC_002695.1 acidic protein; similar to MSYB_ECOLI gi|1787289 (conserved in Escherichia coli K-12); hypothetical protein 1473322 914483 ECs1429 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309456.2 1472948 R 386585 CDS NP_309459.1 15830686 912457 complement(1474803..1475723) 1 NC_002695.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1475723 912457 ECs1432 Escherichia coli O157:H7 str. Sakai lipid A biosynthesis lauroyl acyltransferase NP_309459.1 1474803 R 386585 CDS NP_309460.1 15830687 913919 1475948..1477000 1 NC_002695.1 similar to YCEA_ECOLI gi|1787294 (conserved in Escherichia coli K-12); hypothetical protein 1477000 913919 ECs1433 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309460.1 1475948 D 386585 CDS NP_309461.1 15830688 912645 complement(1477042..1477617) 1 NC_002695.1 similar to YCEI_ECOLI gi|1787295 (conserved in Escherichia coli K-12); hypothetical protein 1477617 912645 ECs1434 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309461.1 1477042 R 386585 CDS NP_309462.1 15830689 914197 complement(1477621..1478187) 1 NC_002695.1 similar to B1057_ECOLI gi|1787296 (conserved in Escherichia coli K-12); cytochrome 1478187 914197 ECs1435 Escherichia coli O157:H7 str. Sakai cytochrome NP_309462.1 1477621 R 386585 CDS NP_309463.1 15830690 914276 complement(1478448..1478588) 1 NC_002695.1 similar to YCEO_ECOLI gi|1787297 (conserved in Escherichia coli K-12); hypothetical protein 1478588 914276 ECs1436 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309463.1 1478448 R 386585 CDS NP_309464.1 15830691 912344 complement(1478609..1479727) 1 NC_002695.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1479727 solA 912344 solA Escherichia coli O157:H7 str. Sakai N-methyltryptophan oxidase NP_309464.1 1478609 R 386585 CDS NP_309465.3 162139709 912354 complement(1479842..1480096) 1 NC_002695.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1480096 bssS 912354 bssS Escherichia coli O157:H7 str. Sakai biofilm formation regulatory protein BssS NP_309465.3 1479842 R 386585 CDS NP_309466.1 15830693 912326 complement(1480386..1480631) 1 NC_002695.1 damage-inducible protein; similar to DINI_ECOLI gi|1787300 (conserved in Escherichia coli K-12); DNA damage-inducible protein I 1480631 912326 ECs1439 Escherichia coli O157:H7 str. Sakai DNA damage-inducible protein I NP_309466.1 1480386 R 386585 CDS NP_309467.1 15830694 914110 complement(1480705..1481751) 1 NC_002695.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1481751 914110 ECs1440 Escherichia coli O157:H7 str. Sakai dihydroorotase NP_309467.1 1480705 R 386585 CDS NP_309468.1 15830695 914105 complement(1481857..1482417) 1 NC_002695.1 similar to YCEB_ECOLI gi|1787302 (conserved in Escherichia coli K-12); hypothetical protein 1482417 914105 ECs1441 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309468.1 1481857 R 386585 CDS NP_309469.1 15830696 912384 complement(1482551..1483198) 1 NC_002695.1 cofactor involved in the reduction of disulfides; glutaredoxin 1483198 912384 ECs1442 Escherichia coli O157:H7 str. Sakai glutaredoxin NP_309469.1 1482551 R 386585 CDS NP_309470.2 38703931 912474 complement(1483262..1484470) 1 NC_002695.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1484470 912474 ECs1443 Escherichia coli O157:H7 str. Sakai multidrug resistance protein MdtH NP_309470.2 1483262 R 386585 CDS NP_309471.1 15830698 912337 1484706..1485290 1 NC_002695.1 similar to RIMJ_ECOLI gi|1787305 (conserved in Escherichia coli K-12); ribosomal-protein-S5-alanine N-acetyltransferase 1485290 912337 ECs1444 Escherichia coli O157:H7 str. Sakai ribosomal-protein-S5-alanine N-acetyltransferase NP_309471.1 1484706 D 386585 CDS NP_309472.1 15830699 913563 1485301..1485948 1 NC_002695.1 similar to YCEH_ECOLI gi|1787306 (conserved in Escherichia coli K-12); hypothetical protein 1485948 913563 ECs1445 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309472.1 1485301 D 386585 CDS NP_309473.1 15830700 914354 1485950..1486873 1 NC_002695.1 similar to MVIM_ECOLI gi|1787307 (conserved in Escherichia coli K-12); hypothetical protein 1486873 914354 ECs1446 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309473.1 1485950 D 386585 CDS NP_309474.1 15830701 912988 1486983..1488518 1 NC_002695.1 similar to MVIN_ECOLI gi|1787309 (conserved in Escherichia coli K-12); hypothetical protein 1488518 912988 ECs1447 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309474.1 1486983 D 386585 CDS NP_309475.1 15830702 912372 complement(1488558..1488974) 1 NC_002695.1 similar to FLGN_ECOLI gi|1787310 (conserved in Escherichia coli K-12); flagella synthesis protein FlgN 1488974 912372 ECs1448 Escherichia coli O157:H7 str. Sakai flagella synthesis protein FlgN NP_309475.1 1488558 R 386585 CDS NP_309476.1 15830703 912416 complement(1488979..1489272) 1 NC_002695.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1489272 912416 ECs1449 Escherichia coli O157:H7 str. Sakai anti-sigma-28 factor FlgM NP_309476.1 1488979 R 386585 CDS NP_309477.1 15830704 913008 complement(1489348..1490007) 1 NC_002695.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1490007 flgA 913008 flgA Escherichia coli O157:H7 str. Sakai flagellar basal body P-ring biosynthesis protein FlgA NP_309477.1 1489348 R 386585 CDS NP_309478.1 15830705 913983 1490162..1490578 1 NC_002695.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1490578 flgB 913983 flgB Escherichia coli O157:H7 str. Sakai flagellar basal-body rod protein FlgB NP_309478.1 1490162 D 386585 CDS NP_309479.1 15830706 913368 1490582..1490986 1 NC_002695.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1490986 flgC 913368 flgC Escherichia coli O157:H7 str. Sakai flagellar basal body rod protein FlgC NP_309479.1 1490582 D 386585 CDS NP_309480.1 15830707 912974 1490998..1491693 1 NC_002695.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1491693 flgD 912974 flgD Escherichia coli O157:H7 str. Sakai flagellar basal body rod modification protein NP_309480.1 1490998 D 386585 CDS NP_309481.1 15830708 914188 1491718..1492923 1 NC_002695.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1492923 flgE 914188 flgE Escherichia coli O157:H7 str. Sakai flagellar hook protein FlgE NP_309481.1 1491718 D 386585 CDS NP_309482.1 15830709 912868 1492943..1493698 1 NC_002695.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1493698 flgF 912868 flgF Escherichia coli O157:H7 str. Sakai flagellar basal body rod protein FlgF NP_309482.1 1492943 D 386585 CDS NP_309483.1 15830710 912784 1493836..1494618 1 NC_002695.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1494618 flgG 912784 flgG Escherichia coli O157:H7 str. Sakai flagellar basal body rod protein FlgG NP_309483.1 1493836 D 386585 CDS NP_309484.1 15830711 912879 1494671..1495369 1 NC_002695.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1495369 flgH 912879 flgH Escherichia coli O157:H7 str. Sakai flagellar basal body L-ring protein NP_309484.1 1494671 D 386585 CDS NP_309485.2 38703932 913952 1495378..1496478 1 NC_002695.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1496478 flgI 913952 flgI Escherichia coli O157:H7 str. Sakai flagellar basal body P-ring protein NP_309485.2 1495378 D 386585 CDS NP_309486.1 15830713 912388 1496478..1497419 1 NC_002695.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1497419 flgJ 912388 flgJ Escherichia coli O157:H7 str. Sakai flagellar rod assembly protein/muramidase FlgJ NP_309486.1 1496478 D 386585 CDS NP_309487.1 15830714 914101 1497485..1499128 1 NC_002695.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1499128 flgK 914101 flgK Escherichia coli O157:H7 str. Sakai flagellar hook-associated protein FlgK NP_309487.1 1497485 D 386585 CDS NP_309488.1 15830715 913031 1499140..1500093 1 NC_002695.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1500093 flgL 913031 flgL Escherichia coli O157:H7 str. Sakai flagellar hook-associated protein FlgL NP_309488.1 1499140 D 386585 CDS NP_309489.1 15830716 912764 complement(1500288..1503473) 1 NC_002695.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1503473 rne 912764 rne Escherichia coli O157:H7 str. Sakai ribonuclease E NP_309489.1 1500288 R 386585 CDS NP_309490.1 15830717 913605 1503554..1503928 1 NC_002695.1 similar to B1085_ECOLI gi|1787326 (conserved in Escherichia coli K-12); hypothetical protein 1503928 913605 ECs1463 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309490.1 1503554 D 386585 CDS NP_309491.1 15830718 913470 1504046..1505005 1 NC_002695.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1505005 913470 ECs1464 Escherichia coli O157:H7 str. Sakai 23S rRNA pseudouridylate synthase C NP_309491.1 1504046 D 386585 CDS NP_309492.2 162139801 912761 complement(1505106..1505690) 1 NC_002695.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1505690 maf 912761 maf Escherichia coli O157:H7 str. Sakai Maf-like protein NP_309492.2 1505106 R 386585 CDS NP_309493.1 15830720 912718 1505889..1506410 1 NC_002695.1 similar to YCED_ECOLI gi|1787329 (conserved in Escherichia coli K-12); hypothetical protein 1506410 912718 ECs1466 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309493.1 1505889 D 386585 CDS NP_309494.1 15830721 912317 1506462..1506635 1 NC_002695.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1506635 rpmF 912317 rpmF Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L32 NP_309494.1 1506462 D 386585 CDS NP_309495.2 162139800 913798 1506716..1507786 1 NC_002695.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1507786 913798 ECs1468 Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate acyltransferase PlsX NP_309495.2 1506716 D 386585 CDS NP_309496.1 15830723 913793 1507854..1508807 1 NC_002695.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1508807 913793 ECs1469 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP synthase NP_309496.1 1507854 D 386585 CDS NP_309497.1 15830724 913863 1508823..1509752 1 NC_002695.1 similar to FABD_ECOLI gi|1787334 (conserved in Escherichia coli K-12); ACP S-malonyltransferase 1509752 913863 ECs1470 Escherichia coli O157:H7 str. Sakai ACP S-malonyltransferase NP_309497.1 1508823 D 386585 CDS NP_309498.1 15830725 913011 1509765..1510499 1 NC_002695.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1510499 fabG 913011 fabG Escherichia coli O157:H7 str. Sakai 3-ketoacyl-ACP reductase NP_309498.1 1509765 D 386585 CDS NP_309499.1 15830726 912360 1510710..1510946 1 NC_002695.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1510946 acpP 912360 acpP Escherichia coli O157:H7 str. Sakai acyl carrier protein NP_309499.1 1510710 D 386585 CDS NP_309500.1 15830727 912652 1511034..1512275 1 NC_002695.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1512275 912652 ECs1473 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP synthase NP_309500.1 1511034 D 386585 CDS NP_309501.1 15830728 913214 1512395..1513204 1 NC_002695.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1513204 913214 ECs1474 Escherichia coli O157:H7 str. Sakai 4-amino-4-deoxychorismate lyase NP_309501.1 1512395 D 386585 CDS NP_309502.1 15830729 912665 1513207..1514229 1 NC_002695.1 similar to YCEG_ECOLI gi|1787339 (conserved in Escherichia coli K-12); hypothetical protein 1514229 912665 ECs1475 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309502.1 1513207 D 386585 CDS NP_309503.1 15830730 912609 1514219..1514860 1 NC_002695.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1514860 tmk 912609 tmk Escherichia coli O157:H7 str. Sakai thymidylate kinase NP_309503.1 1514219 D 386585 CDS NP_309504.1 15830731 912962 1514857..1515861 1 NC_002695.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1515861 912962 ECs1477 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit delta' NP_309504.1 1514857 D 386585 CDS NP_309505.1 15830732 913835 1515872..1516669 1 NC_002695.1 similar to YCFH_ECOLI gi|1787342 (conserved in Escherichia coli K-12); metallodependent hydrolase 1516669 913835 ECs1478 Escherichia coli O157:H7 str. Sakai metallodependent hydrolase NP_309505.1 1515872 D 386585 CDS NP_309506.1 15830733 912363 1516964..1518397 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1518397 912363 ECs1479 Escherichia coli O157:H7 str. Sakai PTS system glucose-specific transporter subunit IIBC NP_309506.1 1516964 D 386585 CDS NP_309507.1 15830734 913890 complement(1518457..1520646) 1 NC_002695.1 similar to FHUE_ECOLI gi|1787344 (conserved in Escherichia coli K-12); ferric-rhodotorulic acid outer membrane transporter 1520646 913890 ECs1480 Escherichia coli O157:H7 str. Sakai ferric-rhodotorulic acid outer membrane transporter NP_309507.1 1518457 R 386585 CDS NP_309508.2 38703933 912424 1520974..1521351 1 NC_002695.1 similar to YCFF_ECOLI gi|1787346 (conserved in Escherichia coli K-12); purine nucleoside phosphoramidase 1521351 912424 ECs1481 Escherichia coli O157:H7 str. Sakai purine nucleoside phosphoramidase NP_309508.2 1520974 D 386585 CDS NP_309509.1 15830736 912483 1521354..1521731 1 NC_002695.1 similar to YCFL_ECOLI gi|1787347 (conserved in Escherichia coli K-12); hypothetical protein 1521731 912483 ECs1482 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309509.1 1521354 D 386585 CDS NP_309510.1 15830737 913505 1521745..1522386 1 NC_002695.1 similar to YCFM_ECOLI gi|1787348 (conserved in Escherichia coli K-12); hypothetical protein 1522386 913505 ECs1483 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309510.1 1521745 D 386585 CDS NP_309511.1 15830738 913746 1522367..1523191 1 NC_002695.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1523191 thiK 913746 thiK Escherichia coli O157:H7 str. Sakai thiamine kinase NP_309511.1 1522367 D 386585 CDS NP_309512.1 15830739 913266 1523202..1524227 1 NC_002695.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1524227 913266 ECs1485 Escherichia coli O157:H7 str. Sakai beta-hexosaminidase NP_309512.1 1523202 D 386585 CDS NP_309513.2 38703934 912679 1524250..1524792 1 NC_002695.1 similar to YCFP_ECOLI gi|1787351 (conserved in Escherichia coli K-12); hypothetical protein 1524792 912679 ECs1486 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309513.2 1524250 D 386585 CDS NP_309514.1 15830741 913292 1525192..1526496 1 NC_002695.1 similar to NDH_ECOLI gi|1787352 (conserved in Escherichia coli K-12); NADH dehydrogenase 1526496 913292 ECs1487 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase NP_309514.1 1525192 D 386585 CDS NP_309515.1 15830742 912979 1526723..1527262 1 NC_002695.1 similar to YCFJ_ECOLI gi|1787353 (conserved in Escherichia coli K-12); hypothetical protein 1527262 912979 ECs1488 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309515.1 1526723 D 386585 CDS NP_309516.2 38703935 912848 complement(1527324..1527956) 1 NC_002695.1 similar to YCFQ_ECOLI gi|1787354 (conserved in Escherichia coli K-12); hypothetical protein 1527956 912848 ECs1489 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309516.2 1527324 R 386585 CDS NP_309517.1 15830744 912348 1528197..1528454 1 NC_002695.1 similar to YCFR_ECOLI gi|1787355 (conserved in Escherichia coli K-12); hypothetical protein 1528454 912348 ECs1490 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309517.1 1528197 D 386585 CDS NP_309518.1 15830745 913870 complement(1528537..1529499) 1 NC_002695.1 similar to YCFS_ECOLI gi|1787356 (conserved in Escherichia coli K-12); hypothetical protein 1529499 913870 ECs1491 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309518.1 1528537 R 386585 CDS NP_309519.1 15830746 913354 complement(1529643..1533089) 1 NC_002695.1 similar to MFD_ECOLI gi|1787357 (conserved in Escherichia coli K-12); transcription-repair coupling factor 1533089 913354 ECs1492 Escherichia coli O157:H7 str. Sakai transcription-repair coupling factor NP_309519.1 1529643 R 386585 CDS NP_309520.1 15830747 912685 complement(1533217..1534290) 1 NC_002695.1 similar to YCFT_ECOLI gi|1787359 (conserved in Escherichia coli K-12); hypothetical protein 1534290 912685 ECs1493 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309520.1 1533217 R 386585 CDS NP_309521.1 15830748 912675 1534552..1535751 1 NC_002695.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1535751 912675 ECs1494 Escherichia coli O157:H7 str. Sakai outer membrane-specific lipoprotein transporter subunit LolC NP_309521.1 1534552 D 386585 CDS NP_309522.2 38703936 913145 1535744..1536445 1 NC_002695.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding protein 1536445 lolD 913145 lolD Escherichia coli O157:H7 str. Sakai lipoprotein transporter ATP-binding protein NP_309522.2 1535744 D 386585 CDS NP_309523.1 15830750 913380 1536445..1537689 1 NC_002695.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1537689 913380 ECs1496 Escherichia coli O157:H7 str. Sakai outer membrane-specific lipoprotein transporter subunit LolE NP_309523.1 1536445 D 386585 CDS NP_309524.1 15830751 912695 1537718..1538629 1 NC_002695.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1538629 912695 ECs1497 Escherichia coli O157:H7 str. Sakai N-acetyl-D-glucosamine kinase NP_309524.1 1537718 D 386585 CDS NP_309525.1 15830752 913467 1538645..1539466 1 NC_002695.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1539466 913467 ECs1498 Escherichia coli O157:H7 str. Sakai NAD-dependent deacetylase NP_309525.1 1538645 D 386585 CDS NP_309526.1 15830753 912995 complement(1539622..1540668) 1 NC_002695.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1540668 potD 912995 potD Escherichia coli O157:H7 str. Sakai spermidine/putrescine ABC transporter substrate-binding protein NP_309526.1 1539622 R 386585 CDS NP_309527.1 15830754 912458 complement(1540665..1541459) 1 NC_002695.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1541459 potC 912458 potC Escherichia coli O157:H7 str. Sakai spermidine/putrescine ABC transporter membrane protein NP_309527.1 1540665 R 386585 CDS NP_309528.1 15830755 912447 complement(1541626..1542744) 1 NC_002695.1 similar to integrase [Escherichia coli prophage e14] gi|3024035|sp|P75969|INTE_ECOLI; integrase 1542744 912447 ECs1501 Escherichia coli O157:H7 str. Sakai integrase NP_309528.1 1541626 R 386585 CDS NP_309529.1 15830756 912339 complement(1542713..1542982) 1 NC_002695.1 similar to excisionase [bacteripohage P21] gi|139674|sp|P27079|VXIS_BPP21; excisionase 1542982 912339 ECs1502 Escherichia coli O157:H7 str. Sakai excisionase NP_309529.1 1542713 R 386585 CDS NP_309530.1 15830757 912505 complement(1543044..1543481) 1 NC_002695.1 hypothetical protein 1543481 912505 ECs1503 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309530.1 1543044 R 386585 CDS NP_309531.1 15830758 912890 1543524..1544081 1 NC_002695.1 hypothetical protein 1544081 912890 ECs1504 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309531.1 1543524 D 386585 CDS NP_309532.1 15830759 916937 complement(1544196..1544426) 1 NC_002695.1 similar to hypothetical protein YdfA [Escherichia coli] gi|140584|sp|P29008|YDFA_ECOLI; hypothetical protein 1544426 916937 ECs1505 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309532.1 1544196 R 386585 CDS NP_309533.1 15830760 912543 complement(1544664..1545140) 1 NC_002695.1 similar to repressor [Escherichia col Rac prophage] gi|3025101|sp|P76062|RACR_ECOLI; phage repressor 1545140 912543 ECs1506 Escherichia coli O157:H7 str. Sakai phage repressor NP_309533.1 1544664 R 386585 CDS NP_309534.1 15830761 914027 1545265..1545588 1 NC_002695.1 similar to YdaS [Escherichia coli] gi|3025102|sp|P76063|YDAS_ECOLI; hypothetical protein 1545588 914027 ECs1507 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309534.1 1545265 D 386585 CDS NP_309535.1 15830762 912648 1545572..1545997 1 NC_002695.1 similar to YdaT [Escherichia coli] gi|3183265|sp|P76165|YDFX_ECOLI; hypothetical protein 1545997 912648 ECs1508 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309535.1 1545572 D 386585 CDS NP_309536.1 15830763 912911 1546066..1547103 1 NC_002695.1 similar to replication termination protein DnaT (prepriming protein I) [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein 1547103 912911 ECs1509 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309536.1 1546066 D 386585 CDS NP_309537.1 15830764 912993 1546964..1547557 1 NC_002695.1 similar to replication protein 14 [Bacteriophage phi-80] gi|137937|sp|P14814|VG14_BPPH8; replication protein 1547557 912993 ECs1510 Escherichia coli O157:H7 str. Sakai replication protein NP_309537.1 1546964 D 386585 CDS NP_309538.1 15830765 913920 1547591..1548307 1 NC_002695.1 similar to YdaW [Escherichia coli] gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein 1548307 913920 ECs1511 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309538.1 1547591 D 386585 CDS NP_309539.1 15830766 913655 1548304..1548621 1 NC_002695.1 hypothetical protein 1548621 913655 ECs1512 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309539.1 1548304 D 386585 CDS NP_309540.1 15830767 912435 1548618..1548920 1 NC_002695.1 similar to Gp57 [Bacteriophage N15] gi|7459176|pir||T13144; hypothetical protein 1548920 912435 ECs1513 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309540.1 1548618 D 386585 CDS NP_309541.1 15830768 912955 1548910..1549227 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881670|dbj|BAA84361.1|; hypothetical protein 1549227 912955 ECs1514 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309541.1 1548910 D 386585 CDS NP_309542.1 15830769 913221 1549181..1549498 1 NC_002695.1 hypothetical protein 1549498 913221 ECs1515 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309542.1 1549181 D 386585 CDS NP_309543.1 15830770 913799 1549485..1549922 1 NC_002695.1 similar to hypothetical protein Ea22 [Bacteriophage lambda] gi|137663|sp|P03756|VE22_LAMBD; hypothetical protein 1549922 913799 ECs1516 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309543.1 1549485 D 386585 CDS NP_309544.1 15830771 913272 1549924..1550115 1 NC_002695.1 hypothetical protein 1550115 913272 ECs1517 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309544.1 1549924 D 386585 CDS NP_309545.1 15830772 912480 1550118..1550705 1 NC_002695.1 similar to hypothetical protein b2363 [Escherichia coli] H65009, hypothetical protein Bacteriophage 933W AAD25410; hypothetical protein 1550705 912480 ECs1518 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309545.1 1550118 D 386585 CDS NP_309547.1 15830774 913183 1551114..1551326 1 NC_002695.1 similar to Hok/Gef family e.g. MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76; prophage maintenance protein 1551326 913183 ECs1520 Escherichia coli O157:H7 str. Sakai prophage maintenance protein NP_309547.1 1551114 D 386585 CDS NP_309548.1 15830775 912325 1551494..1551772 1 NC_002695.1 similar to QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1; hypothetical protein 1551772 912325 ECs1521 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309548.1 1551494 D 386585 CDS NP_309549.1 15830776 912865 1551774..1552823 1 NC_002695.1 similar to b1560 [Escherichia coli] gi|1742555|dbj|BAA15259.1, hypothetical protein A [phage P1] gi|732234|sp|Q06262|YORA_BPP1; hypothetical protein 1552823 912865 ECs1522 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309549.1 1551774 D 386585 CDS NP_309550.1 15830777 912345 1552836..1553210 1 NC_002695.1 similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1, crossover junction endodeoxyribonucleases Rus [Escherichia coli cryptic lambdoid prophage DLP12; crossover junction endodeoxyribonuclease 1553210 912345 ECs1523 Escherichia coli O157:H7 str. Sakai crossover junction endodeoxyribonuclease NP_309550.1 1552836 D 386585 CDS NP_309551.1 15830778 912958 1553207..1554028 1 NC_002695.1 similar to antitermination protein protein Q [Escherichia coli] gi|1742554|dbj|BAA15258.1; antitermination protein 1554028 912958 ECs1524 Escherichia coli O157:H7 str. Sakai antitermination protein NP_309551.1 1553207 D 386585 CDS NP_309552.1 15830779 913386 complement(1554441..1554941) 1 NC_002695.1 hypothetical protein 1554941 913386 ECs1526 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309552.1 1554441 R 386585 CDS NP_309553.1 15830780 913385 1554893..1555078 1 NC_002695.1 hypothetical protein 1555078 913385 ECs1525 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309553.1 1554893 D 386585 CDS NP_309554.1 15830781 913384 1555107..1557044 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881634|dbj|BAA84325.1; hypothetical protein 1557044 913384 ECs1527 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309554.1 1555107 D 386585 CDS NP_309555.1 15830782 913383 1557192..1557374 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4499806|emb|CAB39305.1; hypothetical protein 1557374 913383 ECs1528 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309555.1 1557192 D 386585 CDS NP_309556.1 15830783 913382 1557412..1557681 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881635|dbj|BAA84326.1; hypothetical protein 1557681 913382 ECs1529 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309556.1 1557412 D 386585 CDS NP_309557.1 15830784 913381 1557757..1557972 1 NC_002695.1 similar to holin S protein [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1; holin 1557972 913381 ECs1530 Escherichia coli O157:H7 str. Sakai holin NP_309557.1 1557757 D 386585 CDS NP_309558.1 15830785 913379 1557977..1558321 1 NC_002695.1 similar to YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 1558321 913379 ECs1531 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309558.1 1557977 D 386585 CDS NP_309559.1 15830786 913378 1558372..1558905 1 NC_002695.1 similar to R protein [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin 1558905 913378 ECs1532 Escherichia coli O157:H7 str. Sakai endolysin NP_309559.1 1558372 D 386585 CDS NP_309560.1 15830787 913377 1559176..1559745 1 NC_002695.1 similar to antirepressor protein [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1559745 913377 ECs1533 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_309560.1 1559176 D 386585 CDS NP_309561.1 15830788 913375 1559899..1560366 1 NC_002695.1 host cell lysis; similar to endopeptidases e.g. Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1; endopeptidase 1560366 913375 ECs1534 Escherichia coli O157:H7 str. Sakai endopeptidase NP_309561.1 1559899 D 386585 CDS NP_309563.1 15830790 913372 1560390..1560614 1 NC_002695.1 hypothetical protein 1560614 913372 ECs1536 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309563.1 1560390 D 386585 CDS NP_309564.1 15830791 913371 1560611..1560829 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881640|dbj|BAA84331.1; hypothetical protein 1560829 913371 ECs1537 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309564.1 1560611 D 386585 CDS NP_309565.1 15830792 913370 1560971..1561111 1 NC_002695.1 hypothetical protein 1561111 913370 ECs1538 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309565.1 1560971 D 386585 CDS NP_309566.1 15830793 913367 complement(1561241..1561426) 1 NC_002695.1 similar to hypothetical proteins [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein 1561426 913367 ECs1539 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309566.1 1561241 R 386585 CDS NP_309567.1 15830794 913366 1561468..1561833 1 NC_002695.1 similar to DNAse [Bacteriophage phi-31] gi|1107475|emb|CAA62587.1; Dnase 1561833 913366 ECs1540 Escherichia coli O157:H7 str. Sakai Dnase NP_309567.1 1561468 D 386585 CDS NP_944519.1 38703937 2693789 complement(1561486..1561731) 1 NC_002695.1 hypothetical protein 1561731 2693789 ECs5417 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944519.1 1561486 R 386585 CDS NP_309568.1 15830795 913365 1562123..1562686 1 NC_002695.1 similar to terminase small subunit [Bacillus subtilis PBSX phage] gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 1562686 913365 ECs1541 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_309568.1 1562123 D 386585 CDS NP_309569.1 15830796 913364 1562683..1564344 1 NC_002695.1 similar to hypothetical protein phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; large terminase subunit 1564344 913364 ECs1542 Escherichia coli O157:H7 str. Sakai large terminase subunit NP_309569.1 1562683 D 386585 CDS NP_309570.1 15830797 913361 1564408..1566345 1 NC_002695.1 similar to prohead protease Gp4 [Bacteriophage HK97] gi|1722780|sp|P49860|VP4_BPHK7; major head protein/prohead proteinase 1566345 913361 ECs1543 Escherichia coli O157:H7 str. Sakai major head protein/prohead proteinase NP_309570.1 1564408 D 386585 CDS NP_944520.1 38703938 2693796 1566390..1566611 1 NC_002695.1 hypothetical protein 1566611 2693796 ECs5418 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944520.1 1566390 D 386585 CDS NP_309571.1 15830798 913360 1566557..1569058 1 NC_002695.1 similar to portal protein [Bacteriophage HK022] gi|6863114|gb|AAF30355.1|AF069308_3; portal protein 1569058 913360 ECs1544 Escherichia coli O157:H7 str. Sakai portal protein NP_309571.1 1566557 D 386585 CDS NP_309572.1 15830799 913359 1569138..1569464 1 NC_002695.1 hypothetical protein 1569464 913359 ECs1545 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309572.1 1569138 D 386585 CDS NP_309573.1 15830800 913357 1569474..1569824 1 NC_002695.1 similar to head-tail adaptor [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adapotor 1569824 913357 ECs1546 Escherichia coli O157:H7 str. Sakai head-tail adapotor NP_309573.1 1569474 D 386585 CDS NP_309574.1 15830801 913356 1569821..1570267 1 NC_002695.1 similar to hypothetical phage protein Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 1570267 913356 ECs1547 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309574.1 1569821 D 386585 CDS NP_309575.1 15830802 913355 1570264..1570608 1 NC_002695.1 similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 1570608 913355 ECs1548 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309575.1 1570264 D 386585 CDS NP_309576.1 15830803 913353 1570667..1571383 1 NC_002695.1 similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail subunit 1571383 913353 ECs1549 Escherichia coli O157:H7 str. Sakai major tail subunit NP_309576.1 1570667 D 386585 CDS NP_309577.1 15830804 913352 1571389..1571763 1 NC_002695.1 similar to tail assembly chaperone Gp14 [Bacteriophage HK97] gi|6901600|gb|AAF31103.1; tail assembly chaperone 1571763 913352 ECs1550 Escherichia coli O157:H7 str. Sakai tail assembly chaperone NP_309577.1 1571389 D 386585 CDS NP_309578.1 15830805 913351 1571787..1572068 1 NC_002695.1 similar to Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1; may be produced by translational frameshift; phage tail protein 1572068 913351 ECs1551 Escherichia coli O157:H7 str. Sakai phage tail protein NP_309578.1 1571787 D 386585 CDS NP_309581.1 15830808 913347 1575357..1575698 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1575698 913347 ECs1554 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309581.1 1575357 D 386585 CDS NP_309582.1 15830809 913344 1575698..1576396 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1576396 913344 ECs1555 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309582.1 1575698 D 386585 CDS NP_309583.1 15830810 913343 complement(1576413..1576667) 1 NC_002695.1 similar to regulatory protein Mnt[Bacteriophage P22] gi|133138|sp|P03049|RMNT_BPP22; regulatory protein 1576667 913343 ECs1556 Escherichia coli O157:H7 str. Sakai regulatory protein NP_309583.1 1576413 R 386585 CDS NP_309584.1 15830811 913341 1577190..1578068 1 NC_002695.1 similar to antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1578068 913341 ECs1557 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_309584.1 1577190 D 386585 CDS NP_309585.1 15830812 913340 1578122..1578859 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 1578859 913340 ECs1558 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_309585.1 1578122 D 386585 CDS NP_309586.1 15830813 913339 1578757..1579041 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1579041 913339 ECs1559 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_309586.1 1578757 D 386585 CDS NP_309587.1 15830814 913338 1579163..1581511 1 NC_002695.1 similar to secreted effector protein SopA [Salmonella dublin] gi|5669806|gb|AAD46479.1|AF121227_1; secreted effector protein 1581511 913338 ECs1560 Escherichia coli O157:H7 str. Sakai secreted effector protein NP_309587.1 1579163 D 386585 CDS NP_309588.1 15830815 913337 1582102..1585503 1 NC_002695.1 similar to cytotoxic necrotizing factor type 2 [Escherichia coli] gi|1073353|pir||A55260; hypothetical protein 1585503 913337 ECs1561 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309588.1 1582102 D 386585 CDS NP_309591.1 15830818 913334 complement(1586046..1586951) 1 NC_002695.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1586951 913334 ECs1564 Escherichia coli O157:H7 str. Sakai insertion element IS2 transposase InsD NP_309591.1 1586046 R 386585 CDS NP_309592.1 15830819 913333 complement(1587113..1587274) 1 NC_002695.1 OrfA; similar to hypothetical protein [insertion sequence IS2] gi|140806|sp|P19776|YI21_ECOLI; transposase 1587274 913333 ECs1565 Escherichia coli O157:H7 str. Sakai transposase NP_309592.1 1587113 R 386585 CDS NP_944521.1 38703939 2693776 1587285..1587584 1 NC_002695.1 hypothetical protein 1587584 2693776 ECs5419 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944521.1 1587285 D 386585 CDS NP_309594.1 15830821 913331 complement(1587812..1588087) 1 NC_002695.1 hypothetical protein 1588087 913331 ECs1567 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309594.1 1587812 R 386585 CDS NP_309595.1 15830822 913330 complement(1588148..1589509) 1 NC_002695.1 similar to Yop effector YopM [Yersinia enterocolitica] gi|4324334|gb|AAD16811.1; hypothetical protein 1589509 913330 ECs1568 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309595.1 1588148 R 386585 CDS NP_309596.1 15830823 913329 complement(1589630..1589842) 1 NC_002695.1 hypothetical protein 1589842 913329 ECs1569 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309596.1 1589630 R 386585 CDS NP_309597.1 15830824 913328 complement(1589873..1590736) 1 NC_002695.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1590736 potB 913328 potB Escherichia coli O157:H7 str. Sakai spermidine/putrescine ABC transporter membrane protein NP_309597.1 1589873 R 386585 CDS NP_309598.1 15830825 913327 complement(1590720..1591856) 1 NC_002695.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1591856 potA 913327 potA Escherichia coli O157:H7 str. Sakai putrescine/spermidine ABC transporter ATPase NP_309598.1 1590720 R 386585 CDS NP_309599.1 15830826 913326 1592106..1593332 1 NC_002695.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1593332 913326 ECs1572 Escherichia coli O157:H7 str. Sakai peptidase T NP_309599.1 1592106 D 386585 CDS NP_309600.2 38703940 913325 complement(1593381..1594502) 1 NC_002695.1 similar to YCFD_ECOLI gi|1787373 (conserved in Escherichia coli K-12); hypothetical protein 1594502 913325 ECs1573 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309600.2 1593381 R 386585 CDS NP_309601.1 15830828 913324 1594751..1595980 1 NC_002695.1 similar to integrases e.g. [Shigella dysenteriae] gi|6759954|gb|AAF28112.1|AF153317_4; integrase 1595980 913324 ECs1574 Escherichia coli O157:H7 str. Sakai integrase NP_309601.1 1594751 D 386585 CDS NP_309603.1 15830830 913322 1596591..1597334 1 NC_002695.1 hypothetical protein 1597334 913322 ECs1576 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309603.1 1596591 D 386585 CDS NP_944522.1 38703941 2693777 complement(1597034..1597165) 1 NC_002695.1 hypothetical protein 1597165 2693777 ECs5420 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944522.1 1597034 R 386585 CDS NP_309604.1 15830831 913321 1597360..1597557 1 NC_002695.1 probable cell division repressor; similar to cell division repressor Icd [enterobacteria phage P1] gi|4261623|gb|AAD13923.1|S61175_1; Icd-like protein 1597557 913321 ECs1577 Escherichia coli O157:H7 str. Sakai Icd-like protein NP_309604.1 1597360 D 386585 CDS NP_309605.1 15830832 913320 1597550..1597735 1 NC_002695.1 hypothetical protein 1597735 913320 ECs1578 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309605.1 1597550 D 386585 CDS NP_309606.1 15830833 913319 1597735..1597926 1 NC_002695.1 hypothetical protein 1597926 913319 ECs1579 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309606.1 1597735 D 386585 CDS NP_309607.1 15830834 913318 1597916..1598158 1 NC_002695.1 hypothetical protein 1598158 913318 ECs1580 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309607.1 1597916 D 386585 CDS NP_309608.1 15830835 913316 1598164..1598463 1 NC_002695.1 hypothetical protein 1598463 913316 ECs1581 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309608.1 1598164 D 386585 CDS NP_309612.1 15830839 913312 complement(1600591..1600935) 1 NC_002695.1 hypothetical protein 1600935 913312 ECs1585 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309612.1 1600591 R 386585 CDS NP_309613.1 15830840 913311 1600965..1601216 1 NC_002695.1 hypothetical protein 1601216 913311 ECs1586 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309613.1 1600965 D 386585 CDS NP_309614.1 15830841 913309 1601213..1601623 1 NC_002695.1 similar to single stranded DNA-binding proteins e.g. [Thermotoga maritima] gi|7439946|pir||H72354; single stranded DNA-binding protein 1601623 913309 ECs1587 Escherichia coli O157:H7 str. Sakai single stranded DNA-binding protein NP_309614.1 1601213 D 386585 CDS NP_309615.1 15830842 913308 1601634..1601906 1 NC_002695.1 similar to PerC (BfpW) transcriptional activator of eaeA/bfpA [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional activator 1601906 913308 ECs1588 Escherichia coli O157:H7 str. Sakai transcriptional activator NP_309615.1 1601634 D 386585 CDS NP_309616.2 38703942 913307 1601953..1602255 1 NC_002695.1 hypothetical protein 1602255 913307 ECs1589 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309616.2 1601953 D 386585 CDS NP_309617.1 15830844 913306 1602548..1603705 1 NC_002695.1 similar to major head proteins e.g. phage phi-C31 gp36-like protein [Haemophilus influenzae] gi|6739663|gb|AAF27364.1|AF198256_18 (AF198256); major head protein 1603705 913306 ECs1590 Escherichia coli O157:H7 str. Sakai major head protein NP_309617.1 1602548 D 386585 CDS NP_309618.2 38703943 913305 1603745..1604317 1 NC_002695.1 similar to prohead proteases e.g. phage phi-C31 gp35-like protein [Haemophilus influenzae] gi|6739662|gb|AAF27363.1|AF198256_17; prohead protease 1604317 913305 ECs1591 Escherichia coli O157:H7 str. Sakai prohead protease NP_309618.2 1603745 D 386585 CDS NP_309619.1 15830846 913303 1604319..1605530 1 NC_002695.1 similar to head portal proteins e.g. phage phi-105 ORF25-like protein [Haemophilus influenzae]gi|6739661|gb|AAF27362.1|AF198256_ 16; head portal protein 1605530 913303 ECs1592 Escherichia coli O157:H7 str. Sakai head portal protein NP_309619.1 1604319 D 386585 CDS NP_309620.1 15830847 913301 1605527..1605865 1 NC_002695.1 similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 1605865 913301 ECs1593 Escherichia coli O157:H7 str. Sakai head-tail adaptor NP_309620.1 1605527 D 386585 CDS NP_309621.1 15830848 913302 1605862..1606158 1 NC_002695.1 similar to hypothetical protein [Haemophilus influenzae] gi|6739659|gb|AAF27360.1|AF198256_14, hypothetical protein 30 [Bacillus phage phi-105] gi|7459182|pir||T13519; hypothetical protein 1606158 913302 ECs1594 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309621.1 1605862 D 386585 CDS NP_309622.1 15830849 913298 1606158..1606598 1 NC_002695.1 similar to hypothetical protein [Haemophilus influenzae] gi|6739658|gb|AAF27359.1|AF198256_13; hypothetical protein 1606598 913298 ECs1595 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309622.1 1606158 D 386585 CDS NP_309623.1 15830850 913297 1606591..1606764 1 NC_002695.1 hypothetical protein 1606764 913297 ECs1596 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309623.1 1606591 D 386585 CDS NP_309624.1 15830851 913296 1606888..1607244 1 NC_002695.1 similar to hypothetical protein of genetic island 1 [Haemophilus influenzae] gi|6739657|gb|AAF27358.1|AF198256_12; terminase small subunit 1607244 913296 ECs1597 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_309624.1 1606888 D 386585 CDS NP_309625.1 15830852 913294 1607228..1608889 1 NC_002695.1 similar to terminase large subunits e.g.[Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 1608889 913294 ECs1598 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_309625.1 1607228 D 386585 CDS NP_309626.1 15830853 913293 1608903..1609184 1 NC_002695.1 hypothetical protein 1609184 913293 ECs1599 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309626.1 1608903 D 386585 CDS NP_309628.1 15830855 913290 complement(1610041..1611501) 1 NC_002695.1 sensor protein; similar to PHOQ_ECOLI gi|1787374 (conserved in Escherichia coli K-12); sensor protein PhoQ 1611501 913290 ECs1601 Escherichia coli O157:H7 str. Sakai sensor protein PhoQ NP_309628.1 1610041 R 386585 CDS NP_309629.1 15830856 913289 complement(1611501..1612172) 1 NC_002695.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; PhoP family transcriptional regulator 1612172 913289 ECs1602 Escherichia coli O157:H7 str. Sakai PhoP family transcriptional regulator NP_309629.1 1611501 R 386585 CDS NP_309630.1 15830857 913288 complement(1612341..1613711) 1 NC_002695.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1613711 913288 ECs1603 Escherichia coli O157:H7 str. Sakai adenylosuccinate lyase NP_309630.1 1612341 R 386585 CDS NP_309631.1 15830858 913287 complement(1613715..1614356) 1 NC_002695.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1614356 913287 ECs1604 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309631.1 1613715 R 386585 CDS NP_309632.2 38703944 913286 complement(1614392..1615498) 1 NC_002695.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1615498 mnmA 913286 mnmA Escherichia coli O157:H7 str. Sakai tRNA-specific 2-thiouridylase MnmA NP_309632.2 1614392 R 386585 CDS NP_309633.1 15830860 913284 complement(1615552..1616013) 1 NC_002695.1 similar to B1134_ECOLI gi|1787379 (conserved in Escherichia coli K-12); phosphohydrolase 1616013 913284 ECs1606 Escherichia coli O157:H7 str. Sakai phosphohydrolase NP_309633.1 1615552 R 386585 CDS NP_309634.2 162139799 913282 complement(1616023..1616646) 1 NC_002695.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1616646 913282 ECs1607 Escherichia coli O157:H7 str. Sakai 23S rRNA pseudouridine synthase E NP_309634.2 1616023 R 386585 CDS NP_309635.1 15830862 913281 1616848..1618098 1 NC_002695.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1618098 913281 ECs1608 Escherichia coli O157:H7 str. Sakai isocitrate dehydrogenase NP_309635.1 1616848 D 386585 CDS NP_309636.1 15830863 913280 complement(1618212..1619354) 1 NC_002695.1 similar to integrase [Bacteriophage P21] gi|138558|sp|P27077|VINT_BPP21; intergrase 1619354 913280 ECs1609 Escherichia coli O157:H7 str. Sakai intergrase NP_309636.1 1618212 R 386585 CDS NP_309637.1 15830864 913279 complement(1619344..1619580) 1 NC_002695.1 similar to excisionase [Bacteriophage P21] gi|139674|sp|P27079|VXIS_BPP21; excisionase 1619580 913279 ECs1610 Escherichia coli O157:H7 str. Sakai excisionase NP_309637.1 1619344 R 386585 CDS NP_309638.1 15830865 913278 1619684..1620508 1 NC_002695.1 similar to replication protein GpO [Bacteriophage lambda] gi|215150|gb|AAA96584.1; replication protein 1620508 913278 ECs1611 Escherichia coli O157:H7 str. Sakai replication protein NP_309638.1 1619684 D 386585 CDS NP_309639.1 15830866 913277 1620505..1621206 1 NC_002695.1 similar to replication protein GpP [Bacteriophage lambda] gi|4499785|emb|CAB39284.1; replication protein P 1621206 913277 ECs1612 Escherichia coli O157:H7 str. Sakai replication protein P NP_309639.1 1620505 D 386585 CDS NP_309640.1 15830867 913276 1621203..1621505 1 NC_002695.1 similar to Ren protein [Bacteriophage lambda] gi|139473|sp|P03761|VREN_LAMBD; Ren protein 1621505 913276 ECs1613 Escherichia coli O157:H7 str. Sakai Ren protein NP_309640.1 1621203 D 386585 CDS NP_309641.1 15830868 913273 1621573..1621905 1 NC_002695.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 1621905 emrE 913273 emrE Escherichia coli O157:H7 str. Sakai multidrug efflux protein NP_309641.1 1621573 D 386585 CDS NP_309642.1 15830869 913275 1622150..1623676 1 NC_002695.1 similar to hypothetical protein YbcK [Escherichia coli] gi|2495549|sp|P77698|YBCK_ECOLI, integrase [Bacteriophage A118] gi|1196324|gb|AAB51416.1; hypothetical protein 1623676 913275 ECs1615 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309642.1 1622150 D 386585 CDS NP_309643.1 15830870 913271 1624178..1624633 1 NC_002695.1 DLP12 prophage; hypothetical protein 1624633 913271 ECs1616 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309643.1 1624178 D 386585 CDS NP_309644.1 15830871 913270 1624633..1624803 1 NC_002695.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 1624803 913270 ECs1617 Escherichia coli O157:H7 str. Sakai prophage protein NinE NP_309644.1 1624633 D 386585 CDS NP_309645.1 15830872 913269 1624796..1625086 1 NC_002695.1 similar to YbcO [Escherichia coli cryptic prophage DLP12] gi|2495553|sp|Q47271|YBCO_ECOLI, Gp66 [Bacteriophage HK97] gi|6901638|gb|AAF31141.1; hypothetical protein 1625086 913269 ECs1618 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309645.1 1624796 D 386585 CDS NP_309646.1 15830873 913268 1625083..1625445 1 NC_002695.1 DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 1625445 913268 ECs1619 Escherichia coli O157:H7 str. Sakai endodeoxyribonuclease RUS NP_309646.1 1625083 D 386585 CDS NP_944523.1 38703945 2693778 1625442..1625582 1 NC_002695.1 hypothetical protein 1625582 2693778 ECs5421 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944523.1 1625442 D 386585 CDS NP_309647.1 15830874 913267 1625579..1626268 1 NC_002695.1 similar to antitermination proteins e.g. Q [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; antitermination protein 1626268 913267 ECs1620 Escherichia coli O157:H7 str. Sakai antitermination protein NP_309647.1 1625579 D 386585 CDS NP_309648.1 15830875 913264 1626578..1626895 1 NC_002695.1 similar to holin [Bacteriophage PS3] gi|3676074|emb|CAA09700.1|; holin 1626895 913264 ECs1621 Escherichia coli O157:H7 str. Sakai holin NP_309648.1 1626578 D 386585 CDS NP_309649.1 15830876 913262 1626882..1627358 1 NC_002695.1 lyzozyme; similar to endolysins e.g. [Bacteriophage HK97] gi|6901642|gb|AAF31145.1; endolysin 1627358 913262 ECs1622 Escherichia coli O157:H7 str. Sakai endolysin NP_309649.1 1626882 D 386585 CDS NP_309650.1 15830877 913261 1627355..1627816 1 NC_002695.1 host cell lysis; similar to endopeptidases e.g. [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 1627816 913261 ECs1623 Escherichia coli O157:H7 str. Sakai endopeptidase NP_309650.1 1627355 D 386585 CDS NP_309651.1 15830878 913259 1627575..1627757 1 NC_002695.1 similar to Rs1 precursors e.g. [Bacteriophage lambda] gi|540738|pir||JN0750; lipoprotein Rz1 1627757 913259 ECs1624 Escherichia coli O157:H7 str. Sakai lipoprotein Rz1 NP_309651.1 1627575 D 386585 CDS NP_309652.1 15830879 913257 complement(1627848..1628141) 1 NC_002695.1 similar to Bor protein precursor [Bacteriophage lambda] gi|137520|sp|P26814|VBOR_LAMBD; Bor protein 1628141 913257 ECs1625 Escherichia coli O157:H7 str. Sakai Bor protein NP_309652.1 1627848 R 386585 CDS NP_309653.1 15830880 913256 complement(1628433..1628885) 1 NC_002695.1 similar to hypothetical protein YbcV [Escherichia coli] gi|2495556|sp|P77598|YBCV_ECOLI; hypothetical protein 1628885 913256 ECs1626 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309653.1 1628433 R 386585 CDS NP_309654.1 15830881 913255 1629129..1629335 1 NC_002695.1 similar to YbcW [Escherichia coli] gi|2495557|sp|P75720|YBCW_ECOLI; hypothetical protein 1629335 913255 ECs1627 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309654.1 1629129 D 386585 CDS NP_309655.1 15830882 913254 complement(1629500..1629694) 1 NC_002695.1 similar to hypothetical protein Escherichia coli AAB40755; hypothetical protein 1629694 913254 ECs1628 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309655.1 1629500 R 386585 CDS NP_309656.1 15830883 913253 1630083..1630628 1 NC_002695.1 similar to terminase small subunits e.g. Nu1 [Bacteriophage lambda] gi|139026|sp|P03707|TERS_LAMBD; terminase small subunit 1630628 913253 ECs1629 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_309656.1 1630083 D 386585 CDS NP_309657.1 15830884 913252 1630603..1632528 1 NC_002695.1 similar to terminase large subunits e.g. protein A [Bacteriophage lambda] gi|137616|sp|P03708|TERL_LAMBD; terminase large subunit 1632528 913252 ECs1630 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_309657.1 1630603 D 386585 CDS NP_309658.1 15830885 913251 1632525..1632731 1 NC_002695.1 similar to head-to-tail joining proteins e.g. GpW [Bacteriophage lambda] gi|138415|sp|P03727|VHTJ_LAMBD; head-to-tail joining protein 1632731 913251 ECs1631 Escherichia coli O157:H7 str. Sakai head-to-tail joining protein NP_309658.1 1632525 D 386585 CDS NP_309659.1 15830886 913249 1632728..1634329 1 NC_002695.1 similar to portal proteins e.g. GpB [Bacteriophage lambda] gi|138762|sp|P03710|VMCB_LAMBD; portal protein 1634329 913249 ECs1632 Escherichia coli O157:H7 str. Sakai portal protein NP_309659.1 1632728 D 386585 CDS NP_309660.1 15830887 913247 1634310..1635629 1 NC_002695.1 similar to minor capsid protein e.g. proteins C [Bacteriophage lambda] gi|137565|sp|P03711|VCAC_LAMBD; minor capsid protein 1635629 913247 ECs1633 Escherichia coli O157:H7 str. Sakai minor capsid protein NP_309660.1 1634310 D 386585 CDS NP_309661.1 15830888 913245 1635639..1635971 1 NC_002695.1 similar to major capsid proteins e.g. GpD [Bacteriophage lambda] gi|137566|sp|P03712|VCAD_LAMBD; major capsid protein 1635971 913245 ECs1634 Escherichia coli O157:H7 str. Sakai major capsid protein NP_309661.1 1635639 D 386585 CDS NP_309662.1 15830889 913244 1636027..1637052 1 NC_002695.1 similar to major capsid proteins e.g. GpE [Bacteriophage lambda] gi|116752|sp|P03713|HEAD_LAMBD; major capsid protein 1637052 913244 ECs1635 Escherichia coli O157:H7 str. Sakai major capsid protein NP_309662.1 1636027 D 386585 CDS NP_309663.1 15830890 913243 1637094..1637492 1 NC_002695.1 similar to DNA packaging proteins e.g. GpFI [Bacteriophage lambda] gi|139324|sp|P03709|VPF1_LAMBD; DNA packaging protein 1637492 913243 ECs1636 Escherichia coli O157:H7 str. Sakai DNA packaging protein NP_309663.1 1637094 D 386585 CDS NP_309664.1 15830891 913242 1637504..1637857 1 NC_002695.1 similar to minor capsid proteins e.g. GpFII [Bacteriophage lambda] gi|137575|sp|P03714|VCF2_LAMBD; minor capsid protein 1637857 913242 ECs1637 Escherichia coli O157:H7 str. Sakai minor capsid protein NP_309664.1 1637504 D 386585 CDS NP_309665.1 15830892 913240 1637869..1638447 1 NC_002695.1 similar to minor tail proteins e.g. GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein 1638447 913240 ECs1638 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309665.1 1637869 D 386585 CDS NP_309666.1 15830893 913239 1638444..1638839 1 NC_002695.1 similar to minor tail proteins e.g. GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein 1638839 913239 ECs1639 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309666.1 1638444 D 386585 CDS NP_309667.1 15830894 913238 1638847..1639587 1 NC_002695.1 similar to major tail proteins e.g. GpV of [Bacteriophage lambda] gi|138848|sp|P03733|VMTV_LAMBD; major tail protein V 1639587 913238 ECs1640 Escherichia coli O157:H7 str. Sakai major tail protein V NP_309667.1 1638847 D 386585 CDS NP_309668.1 15830895 913237 1639603..1640025 1 NC_002695.1 similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 1640025 913237 ECs1641 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309668.1 1639603 D 386585 CDS NP_309669.1 15830896 913236 1640007..1640441 1 NC_002695.1 similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein 1640441 913236 ECs1642 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309669.1 1640007 D 386585 CDS NP_309670.1 15830897 913235 1640434..1642983 1 NC_002695.1 similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 1642983 913235 ECs1643 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_309670.1 1640434 D 386585 CDS NP_309671.1 15830898 913234 1642980..1643309 1 NC_002695.1 similar to minor tail proteins e.g. GpM of [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1643309 913234 ECs1644 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309671.1 1642980 D 386585 CDS NP_309672.1 15830899 913233 1643309..1644007 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1644007 913233 ECs1645 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309672.1 1643309 D 386585 CDS NP_309673.1 15830900 913232 1644013..1644756 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 1644756 913232 ECs1646 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_309673.1 1644013 D 386585 CDS NP_309674.1 15830901 913231 1644654..1645325 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1645325 913231 ECs1647 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_309674.1 1644654 D 386585 CDS NP_309675.1 15830902 913230 1645386..1648784 1 NC_002695.1 similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1648784 913230 ECs1648 Escherichia coli O157:H7 str. Sakai host specificity protein NP_309675.1 1645386 D 386585 CDS NP_309676.1 15830903 913229 1648851..1649450 1 NC_002695.1 similar to membrane protein Lom precursors e.g. [prophage P-EibA gi|7532789|gb|AAF63231.1|AF151091_2, [Bacteriophage lambda] gi|138693|sp|P03701|VLOM_LAMBD; membrane protein 1649450 913229 ECs1649 Escherichia coli O157:H7 str. Sakai membrane protein NP_309676.1 1648851 D 386585 CDS NP_309677.1 15830904 913228 1649515..1652430 1 NC_002695.1 similar to probable tail fiber proteins e.g. Gp37 [Escherichia coli] gi|7466858|pir||G64887; tail fiber protein 1652430 913228 ECs1650 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_309677.1 1649515 D 386585 CDS NP_309678.1 15830905 913227 1652430..1653011 1 NC_002695.1 similar to tail fiber assembly proteins e.g. Orf194 [Bacteriophage lambda] gi|139990|sp|P03740|Y194_LAMBD; tail fiber assembly protein 1653011 913227 ECs1651 Escherichia coli O157:H7 str. Sakai tail fiber assembly protein NP_309678.1 1652430 D 386585 CDS NP_309679.1 15830906 913226 complement(1653131..1654021) 1 NC_002695.1 similar to hypothetical proteins e.g. catalase [Salmonella typhimurium] gi|7162108|emb|CAB76676.1; catalase 1654021 913226 ECs1652 Escherichia coli O157:H7 str. Sakai catalase NP_309679.1 1653131 R 386585 CDS NP_309680.1 15830907 913225 complement(1654040..1654546) 1 NC_002695.1 similar to hypothetical proteins e.g. YciE [Escherichia coli] gi|775201|gb|AAA65179.1; hypothetical protein 1654546 913225 ECs1653 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309680.1 1654040 R 386585 CDS NP_309681.1 15830908 913224 complement(1654583..1655083) 1 NC_002695.1 similar to hypothetical proteins e.g. YciF [Escherichia coli] gi|140432|sp|P21362|YCIF_ECOLI; hypothetical protein 1655083 913224 ECs1654 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309681.1 1654583 R 386585 CDS NP_309682.1 15830909 913223 complement(1655162..1655344) 1 NC_002695.1 similar to hypothetical proteins e.g. YciG-homolog [Salmonella typhimurium] gi|6851081|emb|CAB71036.1; hypothetical protein 1655344 913223 ECs1655 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309682.1 1655162 R 386585 CDS NP_309683.1 15830910 913222 complement(1655842..1656273) 1 NC_002695.1 similar to hypothetical proteins e.g. ybcY [Escherichia coli] gi|2495559|sp|P77460|YBCY_ECOLI; hypothetical protein 1656273 913222 ECs1656 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309683.1 1655842 R 386585 CDS NP_309684.1 15830911 913219 1656567..1656815 1 NC_002695.1 similar to hypothetical proteins e.g. YlcE [Escherichia coli] gi|3025212|sp|P77087|YLCE_ECOLI; hypothetical protein 1656815 913219 ECs1657 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309684.1 1656567 D 386585 CDS NP_309685.1 15830912 913218 1656891..1657271 1 NC_002695.1 similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 EDL933] gi|3414881|gb|AAC31492.1; hypothetical protein 1657271 913218 ECs1658 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309685.1 1656891 D 386585 CDS NP_309686.1 15830913 913217 1657268..1657615 1 NC_002695.1 similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 EDL933] gi|3414882|gb|AAC31493.1; hypothetical protein 1657615 913217 ECs1659 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309686.1 1657268 D 386585 CDS NP_309687.1 15830914 913216 1657665..1659203 1 NC_002695.1 similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 EDL933] gi|3414883|gb|AAC31494.1; hypothetical protein 1659203 913216 ECs1660 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309687.1 1657665 D 386585 CDS NP_309689.1 15830916 913213 complement(1659506..1660990) 1 NC_002695.1 similar to hypothetical protein [plasmid F] gi|8918853|dbj|BAA97900.1; hypothetical protein 1660990 913213 ECs1662 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309689.1 1659506 R 386585 CDS NP_309690.1 15830917 913212 complement(1661177..1662130) 1 NC_002695.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 1662130 913212 ECs1663 Escherichia coli O157:H7 str. Sakai outer membrane protease NP_309690.1 1661177 R 386585 CDS NP_309691.1 15830918 913211 1662629..1663213 1 NC_002695.1 similar to hypothetical proteins e.g. DNA binding protein [Streptomyces coelicolor A3(2)] gi|6855358|emb|CAB71249.1; hypothetical protein 1663213 913211 ECs1664 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309691.1 1662629 D 386585 CDS NP_309692.1 15830919 913209 1663387..1663713 1 NC_002695.1 OrfA; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 1663713 913209 ECs1665 Escherichia coli O157:H7 str. Sakai transposase NP_309692.1 1663387 D 386585 CDS NP_309693.1 15830920 913208 1663710..1664600 1 NC_002695.1 OrfB; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 1664600 913208 ECs1666 Escherichia coli O157:H7 str. Sakai transposase NP_309693.1 1663710 D 386585 CDS NP_309694.1 15830921 913207 1664690..1665394 1 NC_002695.1 similar to hypothetical proteins e.g. part (1336-1569 in 1569 aa) of YPJA_ECOLI gi|2507221|sp|P52143; hypothetical protein 1665394 913207 ECs1667 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309694.1 1664690 D 386585 CDS NP_309695.1 15830922 913206 complement(1665766..1666032) 1 NC_002695.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1666032 minE 913206 minE Escherichia coli O157:H7 str. Sakai cell division topological specificity factor MinE NP_309695.1 1665766 R 386585 CDS NP_309696.1 15830923 913204 complement(1666036..1666848) 1 NC_002695.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1666848 913204 ECs1669 Escherichia coli O157:H7 str. Sakai cell division inhibitor MinD NP_309696.1 1666036 R 386585 CDS NP_309697.1 15830924 913203 complement(1666872..1667567) 1 NC_002695.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1667567 minC 913203 minC Escherichia coli O157:H7 str. Sakai septum formation inhibitor NP_309697.1 1666872 R 386585 CDS NP_309698.1 15830925 913202 1668087..1668455 1 NC_002695.1 similar to YCGJ_ECOLI gi|1787425 (conserved in Escherichia coli K-12); hypothetical protein 1668455 913202 ECs1671 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309698.1 1668087 D 386585 CDS NP_309699.1 15830926 913201 complement(1668558..1668959) 1 NC_002695.1 similar to YCGK_ECOLI gi|1787426 (conserved in Escherichia coli K-12); hypothetical protein 1668959 913201 ECs1672 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309699.1 1668558 R 386585 CDS NP_309700.1 15830927 913200 1668988..1669188 1 NC_002695.1 hypothetical protein 1669188 913200 ECs1673 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309700.1 1668988 D 386585 CDS NP_309701.2 38703946 913199 1669200..1669493 1 NC_002695.1 similar to YCGL_ECOLI gi|1787427 (conserved in Escherichia coli K-12); hypothetical protein 1669493 913199 ECs1674 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309701.2 1669200 D 386585 CDS NP_309702.1 15830929 913198 1669565..1670224 1 NC_002695.1 similar to B1180_ECOLI gi|1787428 (conserved in Escherichia coli K-12); hypothetical protein 1670224 913198 ECs1675 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309702.1 1669565 D 386585 CDS NP_309703.3 162139710 913197 1670316..1670762 1 NC_002695.1 similar to YCGN_ECOLI gi|1787429 (conserved in Escherichia coli K-12); hypothetical protein 1670762 913197 ECs1676 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309703.3 1670316 D 386585 CDS NP_309704.1 15830931 913196 complement(1670969..1671886) 1 NC_002695.1 Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E 1671886 hlyE 913196 hlyE Escherichia coli O157:H7 str. Sakai hemolysin E NP_309704.1 1670969 R 386585 CDS NP_309705.1 15830932 913194 1672253..1672672 1 NC_002695.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1672672 913194 ECs1678 Escherichia coli O157:H7 str. Sakai DNA polymerase V subunit UmuD NP_309705.1 1672253 D 386585 CDS NP_309706.1 15830933 913193 1672672..1673940 1 NC_002695.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1673940 umuC 913193 umuC Escherichia coli O157:H7 str. Sakai DNA polymerase V subunit UmuC NP_309706.1 1672672 D 386585 CDS NP_309707.1 15830934 913192 complement(1673986..1674516) 1 NC_002695.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1674516 913192 ECs1680 Escherichia coli O157:H7 str. Sakai disulfide bond formation protein B NP_309707.1 1673986 R 386585 CDS NP_309708.1 15830935 913191 complement(1674662..1676203) 1 NC_002695.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1676203 nhaB 913191 nhaB Escherichia coli O157:H7 str. Sakai sodium/proton antiporter NP_309708.1 1674662 R 386585 CDS NP_309709.1 15830936 913189 1676425..1677144 1 NC_002695.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1677144 913189 ECs1682 Escherichia coli O157:H7 str. Sakai fatty acid metabolism regulator NP_309709.1 1676425 D 386585 CDS NP_309710.1 15830937 913188 complement(1677196..1678728) 1 NC_002695.1 similar to YCGB_ECOLI gi|1787437 (conserved in Escherichia coli K-12); SpoVR family protein 1678728 913188 ECs1683 Escherichia coli O157:H7 str. Sakai SpoVR family protein NP_309710.1 1677196 R 386585 CDS NP_309711.1 15830938 913186 1679091..1680389 1 NC_002695.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1680389 913186 ECs1684 Escherichia coli O157:H7 str. Sakai D-amino acid dehydrogenase small subunit NP_309711.1 1679091 D 386585 CDS NP_309713.2 162139798 913182 complement(1681862..1683598) 1 NC_002695.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1683598 913182 ECs1686 Escherichia coli O157:H7 str. Sakai potassium/proton antiporter NP_309713.2 1681862 R 386585 CDS NP_309714.1 15830941 913181 complement(1683694..1684608) 1 NC_002695.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1684608 ldcA 913181 ldcA Escherichia coli O157:H7 str. Sakai L,D-carboxypeptidase A NP_309714.1 1683694 R 386585 CDS NP_309715.1 15830942 913179 1684594..1685319 1 NC_002695.1 similar to MLTE_ECOLI gi|1787442 (conserved in Escherichia coli K-12); murein transglycosylase E 1685319 913179 ECs1687 Escherichia coli O157:H7 str. Sakai murein transglycosylase E NP_309715.1 1684594 D 386585 CDS NP_309716.1 15830943 913178 complement(1685507..1686397) 1 NC_002695.1 OrfB; transposase insertion sequence IS629; similar to gi|7443862|pir|T00240; transposase 1686397 913178 ECs1689 Escherichia coli O157:H7 str. Sakai transposase NP_309716.1 1685507 R 386585 CDS NP_309717.1 15830944 913176 complement(1686394..1686720) 1 NC_002695.1 OrfA; transposase insertion sequence IS629; similar to hypothetical proteins. e.g. [Shigella flexneri SHI-2 pathogenicity island] gi|5532454|gb|AAD44738.1|AF141323_9; transposase 1686720 913176 ECs1690 Escherichia coli O157:H7 str. Sakai transposase NP_309717.1 1686394 R 386585 CDS NP_309718.1 15830945 913173 complement(1686772..1687368) 1 NC_002695.1 similar to f YCGR_ECOLI gi|1787443; hypothetical protein 1687368 913173 ECs1691 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309718.1 1686772 R 386585 CDS NP_309719.1 15830946 913172 1687569..1687823 1 NC_002695.1 similar to YMGE_ECOLI gi|1787445 (conserved in Escherichia coli K-12); hypothetical protein 1687823 913172 ECs1692 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309719.1 1687569 D 386585 CDS NP_309720.1 15830947 913171 complement(1687873..1689843) 1 NC_002695.1 similar to TonB dependent outer membrane receptor PrrA [Escherichia coli CFT073] gi|3661477|gb|AAC61709.1; TonB dependent outer membrane receptor 1689843 913171 ECs1693 Escherichia coli O157:H7 str. Sakai TonB dependent outer membrane receptor NP_309720.1 1687873 R 386585 CDS NP_309721.1 15830948 913170 complement(1689869..1690723) 1 NC_002695.1 involved in molybdenum transport; molybdenum transport protein ModD 1690723 913170 ECs1694 Escherichia coli O157:H7 str. Sakai molybdenum transport protein ModD NP_309721.1 1689869 R 386585 CDS NP_309724.1 15830951 913166 complement(1691542..1692300) 1 NC_002695.1 similar to ferric enterobactin transport ATP-binding protein [Escherichia coli CFT073] gi|3661480|gb|AAC61712.1; ferric enterobactin transport ATP-binding protein 1692300 913166 ECs1697 Escherichia coli O157:H7 str. Sakai ferric enterobactin transport ATP-binding protein NP_309724.1 1691542 R 386585 CDS NP_309725.1 15830952 913165 complement(1692297..1693277) 1 NC_002695.1 permease; similar to ABC transporter permeases e.g. [Haemophilus influenzae] gi|2501391|sp|Q57130|YE71_HAEIN; ABC transporter permease 1693277 913165 ECs1698 Escherichia coli O157:H7 str. Sakai ABC transporter permease NP_309725.1 1692297 R 386585 CDS NP_309726.1 15830953 913164 complement(1693277..1694299) 1 NC_002695.1 similar to iron (iii) ABC transporter, ATP-binding protein [Pyrococcus abyssi (strain Orsay)] gi|7519847|pir||A75077; ABC transporter ATP-binding protein 1694299 913164 ECs1699 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_309726.1 1693277 R 386585 CDS NP_309727.1 15830954 913163 complement(1694407..1694607) 1 NC_002695.1 hypothetical protein 1694607 913163 ECs1700 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309727.1 1694407 R 386585 CDS NP_309730.1 15830957 913160 complement(1696639..1698060) 1 NC_002695.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM 1698060 913160 ECs1703 Escherichia coli O157:H7 str. Sakai dihydroxyacetone kinase subunit DhaM NP_309730.1 1696639 R 386585 CDS NP_309731.1 15830958 913159 complement(1698068..1698700) 1 NC_002695.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1698700 913159 ECs1704 Escherichia coli O157:H7 str. Sakai dihydroxyacetone kinase subunit DhaL NP_309731.1 1698068 R 386585 CDS NP_309732.3 162139711 913158 complement(1698711..1699811) 1 NC_002695.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1699811 913158 ECs1705 Escherichia coli O157:H7 str. Sakai dihydroxyacetone kinase subunit DhaK NP_309732.3 1698711 R 386585 CDS NP_309733.1 15830960 913157 1700000..1700476 1 NC_002695.1 similar to B1201_ECOLI (DhaR) gi|1787451|P76016; hypothetical protein 1700476 913157 ECs1706 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309733.1 1700000 D 386585 CDS NP_309734.1 15830961 913156 complement(1700116..1701759) 1 NC_002695.1 similar to adhesion and penetration protein B1202_ECOLI gi|1787452 (conserved in Escherichia coli K-12); hypothetical protein 1701759 913156 ECs1707 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309734.1 1700116 R 386585 CDS NP_944524.1 38703949 2693757 1702104..1702307 1 NC_002695.1 hypothetical protein 1702307 2693757 ECs5422 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944524.1 1702104 D 386585 CDS NP_309735.1 15830962 913155 complement(1702603..1703694) 1 NC_002695.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1703694 913155 ECs1708 Escherichia coli O157:H7 str. Sakai GTP-dependent nucleic acid-binding protein EngD NP_309735.1 1702603 R 386585 CDS NP_309736.1 15830963 913154 complement(1703811..1704395) 1 NC_002695.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1704395 913154 ECs1709 Escherichia coli O157:H7 str. Sakai peptidyl-tRNA hydrolase NP_309736.1 1703811 R 386585 CDS NP_309737.1 15830964 913153 1704673..1704951 1 NC_002695.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1704951 913153 ECs1710 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309737.1 1704673 D 386585 CDS NP_309738.1 15830965 913152 complement(1705006..1706658) 1 NC_002695.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1706658 913152 ECs1711 Escherichia coli O157:H7 str. Sakai sulfate transporter YchM NP_309738.1 1705006 R 386585 CDS NP_309739.1 15830966 913151 complement(1706810..1707757) 1 NC_002695.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1707757 913151 ECs1712 Escherichia coli O157:H7 str. Sakai ribose-phosphate pyrophosphokinase NP_309739.1 1706810 R 386585 CDS NP_309740.1 15830967 913150 complement(1707908..1708759) 1 NC_002695.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1708759 ipk 913150 ipk Escherichia coli O157:H7 str. Sakai 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_309740.1 1707908 R 386585 CDS NP_309741.1 15830968 913149 complement(1708759..1709382) 1 NC_002695.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1709382 lolB 913149 lolB Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein LolB NP_309741.1 1708759 R 386585 CDS NP_309742.1 15830969 913148 1709596..1710852 1 NC_002695.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1710852 hemA 913148 hemA Escherichia coli O157:H7 str. Sakai glutamyl-tRNA reductase NP_309742.1 1709596 D 386585 CDS NP_309743.1 15830970 913147 1710894..1711976 1 NC_002695.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1711976 prfA 913147 prfA Escherichia coli O157:H7 str. Sakai peptide chain release factor 1 NP_309743.1 1710894 D 386585 CDS NP_309744.1 15830971 913144 1711976..1712809 1 NC_002695.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1712809 913144 ECs1717 Escherichia coli O157:H7 str. Sakai N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_309744.1 1711976 D 386585 CDS NP_309745.1 15830972 913143 1712806..1713198 1 NC_002695.1 similar to B1213_ECOLI gi|1787464 (conserved in Escherichia coli K-12); transcriptional regulator 1713198 913143 ECs1718 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_309745.1 1712806 D 386585 CDS NP_309746.1 15830973 913142 1713202..1714011 1 NC_002695.1 similar to YCHA_ECOLI gi|1787465 (conserved in Escherichia coli K-12); transcriptional regulator 1714011 913142 ECs1719 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_309746.1 1713202 D 386585 CDS NP_309747.1 15830974 913141 1714047..1714901 1 NC_002695.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1714901 913141 ECs1720 Escherichia coli O157:H7 str. Sakai 2-dehydro-3-deoxyphosphooctonate aldolase NP_309747.1 1714047 D 386585 CDS NP_309748.1 15830975 913140 complement(1716091..1717191) 1 NC_002695.1 similar to CHAA_ECOLI gi|1787468 (conserved in Escherichia coli K-12); calcium/sodium:proton antiporter 1717191 913140 ECs1721 Escherichia coli O157:H7 str. Sakai calcium/sodium:proton antiporter NP_309748.1 1716091 R 386585 CDS NP_309749.1 15830976 913139 1717461..1717691 1 NC_002695.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1717691 chaB 913139 chaB Escherichia coli O157:H7 str. Sakai cation transport regulator NP_309749.1 1717461 D 386585 CDS NP_309750.1 15830977 913138 1717828..1718547 1 NC_002695.1 similar to CHAC_ECOLI gi|1787470 (conserved in Escherichia coli K-12); cation transport regulator 1718547 913138 ECs1723 Escherichia coli O157:H7 str. Sakai cation transport regulator NP_309750.1 1717828 D 386585 CDS NP_309751.1 15830978 913137 complement(1718591..1718944) 1 NC_002695.1 similar to YCHN_ECOLI gi|1787471 (conserved in Escherichia coli K-12); hypothetical protein 1718944 913137 ECs1724 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309751.1 1718591 R 386585 CDS NP_309752.1 15830979 913136 1719271..1720524 1 NC_002695.1 similar to YCHP_ECOLI gi|1787472 (conserved in Escherichia coli K-12); hypothetical protein 1720524 913136 ECs1725 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309752.1 1719271 D 386585 CDS NP_309753.1 15830980 913135 complement(1720525..1721175) 1 NC_002695.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1721175 913135 ECs1726 Escherichia coli O157:H7 str. Sakai transcriptional regulator NarL NP_309753.1 1720525 R 386585 CDS NP_309754.1 15830981 913134 complement(1721168..1722964) 1 NC_002695.1 similar to NARX_ECOLI gi|1787474 (conserved in Escherichia coli K-12); nitrate/nitrite sensor protein NarX 1722964 913134 ECs1727 Escherichia coli O157:H7 str. Sakai nitrate/nitrite sensor protein NarX NP_309754.1 1721168 R 386585 CDS NP_944525.1 38703950 2693758 1722990..1723208 1 NC_002695.1 hypothetical protein 1723208 2693758 ECs5423 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944525.1 1722990 D 386585 CDS NP_309755.1 15830982 913133 1723303..1724694 1 NC_002695.1 similar to NARK_ECOLI gi|1787475 (conserved in Escherichia coli K-12); nitrite extrusion protein 1724694 913133 ECs1728 Escherichia coli O157:H7 str. Sakai nitrite extrusion protein NP_309755.1 1723303 D 386585 CDS NP_309756.1 15830983 913132 1725087..1728830 1 NC_002695.1 similar to NARG_ECOLI gi|1787477 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit alpha 1728830 913132 ECs1729 Escherichia coli O157:H7 str. Sakai nitrate reductase 1 subunit alpha NP_309756.1 1725087 D 386585 CDS NP_309757.1 15830984 913131 1728827..1730365 1 NC_002695.1 similar to NARH_ECOLI gi|1787478 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit beta 1730365 913131 ECs1730 Escherichia coli O157:H7 str. Sakai nitrate reductase 1 subunit beta NP_309757.1 1728827 D 386585 CDS NP_309758.1 15830985 913130 1730362..1731072 1 NC_002695.1 similar to NARJ_ECOLI gi|1787479 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit delta 1731072 913130 ECs1731 Escherichia coli O157:H7 str. Sakai nitrate reductase 1 subunit delta NP_309758.1 1730362 D 386585 CDS NP_309759.1 15830986 913128 1731072..1731749 1 NC_002695.1 similar to NARI_ECOLI gi|1787480 (conserved in Escherichia coli K-12); nitrate reductase 1 subunit gamma 1731749 913128 ECs1732 Escherichia coli O157:H7 str. Sakai nitrate reductase 1 subunit gamma NP_309759.1 1731072 D 386585 CDS NP_309760.1 15830987 913127 1731932..1732207 1 NC_002695.1 similar to B1228_ECOLI gi|1787481 (conserved in Escherichia coli K-12); hypothetical protein 1732207 913127 ECs1733 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309760.1 1731932 D 386585 CDS NP_309761.1 15830988 913121 complement(1732827..1733669) 1 NC_002695.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1733669 purU 913121 purU Escherichia coli O157:H7 str. Sakai formyltetrahydrofolate deformylase NP_309761.1 1732827 R 386585 CDS NP_309762.1 15830989 913117 complement(1733719..1734177) 1 NC_002695.1 similar to YCHJ_ECOLI gi|1787484 (conserved in Escherichia coli K-12); hypothetical protein 1734177 913117 ECs1735 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309762.1 1733719 R 386585 CDS NP_309763.1 15830990 913116 1734251..1735195 1 NC_002695.1 similar to YCHK_ECOLI gi|1787485 (conserved in Escherichia coli K-12); hypothetical protein 1735195 913116 ECs1736 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309763.1 1734251 D 386585 CDS NP_309764.1 15830991 913115 1735287..1736300 1 NC_002695.1 similar to HNR_ECOLI gi|1787487 (conserved in Escherichia coli K-12); response regulator of RpoS 1736300 913115 ECs1737 Escherichia coli O157:H7 str. Sakai response regulator of RpoS NP_309764.1 1735287 D 386585 CDS NP_309765.1 15830992 913114 1736502..1737410 1 NC_002695.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1737410 913114 ECs1738 Escherichia coli O157:H7 str. Sakai UTP-glucose-1-phosphate uridylyltransferase NP_309765.1 1736502 D 386585 CDS NP_309766.1 15830993 913113 complement(1737554..1737967) 1 NC_002695.1 similar to HNS_ECOLI gi|1787489 (conserved in Escherichia coli K-12); global DNA-binding transcriptional dual regulator H-NS 1737967 913113 ECs1739 Escherichia coli O157:H7 str. Sakai global DNA-binding transcriptional dual regulator H-NS NP_309766.1 1737554 R 386585 CDS NP_309767.1 15830994 913112 1738571..1739188 1 NC_002695.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1739188 913112 ECs1740 Escherichia coli O157:H7 str. Sakai thymidine kinase NP_309767.1 1738571 D 386585 CDS NP_309768.1 15830995 913110 complement(1739489..1742164) 1 NC_002695.1 similar to ADHE_ECOLI gi|1787493 (conserved in Escherichia coli K-12); bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1742164 913110 ECs1741 Escherichia coli O157:H7 str. Sakai bifunctional acetaldehyde-CoA/alcohol dehydrogenase NP_309768.1 1739489 R 386585 CDS NP_309769.1 15830996 913109 1742641..1743288 1 NC_002695.1 similar to YCHE_ECOLI gi|1787494 (conserved in Escherichia coli K-12); hypothetical protein 1743288 913109 ECs1742 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309769.1 1742641 D 386585 CDS NP_309770.1 15830997 913108 1744026..1745657 1 NC_002695.1 similar to OPPA_ECOLI gi|1787495 (conserved in Escherichia coli K-12); oligopeptide transport periplasmic binding protein 1745657 913108 ECs1743 Escherichia coli O157:H7 str. Sakai oligopeptide transport periplasmic binding protein NP_309770.1 1744026 D 386585 CDS NP_309771.1 15830998 913107 1745743..1746663 1 NC_002695.1 similar to OPPB_ECOLI gi|1787497 (conserved in Escherichia coli K-12); oligopeptide transporter permease 1746663 oppB 913107 oppB Escherichia coli O157:H7 str. Sakai oligopeptide transporter permease NP_309771.1 1745743 D 386585 CDS NP_309772.1 15830999 913106 1746678..1747586 1 NC_002695.1 similar to OPPC_ECOLI gi|1787498 (conserved in Escherichia coli K-12); hypothetical protein 1747586 913106 ECs1745 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309772.1 1746678 D 386585 CDS NP_309773.1 15831000 913105 1747598..1748611 1 NC_002695.1 similar to OPPD_ECOLI gi|1787499 (conserved in Escherichia coli K-12); oligopeptide ABC transporter ATP-binding protein 1748611 oppD 913105 oppD Escherichia coli O157:H7 str. Sakai oligopeptide ABC transporter ATP-binding protein NP_309773.1 1747598 D 386585 CDS NP_309774.1 15831001 913104 1748608..1749612 1 NC_002695.1 similar to OPPF_ECOLI gi|1787500 (conserved in Escherichia coli K-12); hypothetical protein 1749612 913104 ECs1747 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309774.1 1748608 D 386585 CDS NP_309775.2 38703951 913103 complement(1749665..1749994) 1 NC_002695.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1749994 913103 ECs1748 Escherichia coli O157:H7 str. Sakai dsDNA-mimic protein NP_309775.2 1749665 R 386585 CDS NP_309776.1 15831003 913102 complement(1750029..1751489) 1 NC_002695.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1751489 cls 913102 cls Escherichia coli O157:H7 str. Sakai cardiolipin synthetase NP_309776.1 1750029 R 386585 CDS NP_944526.1 38703952 2693742 1751521..1751805 1 NC_002695.1 hypothetical protein 1751805 2693742 ECs5426 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944526.1 1751521 D 386585 CDS NP_309777.1 15831004 913101 complement(1751860..1753113) 1 NC_002695.1 similar to KCH_ECOLI gi|1787503 (conserved in Escherichia coli K-12); voltage-gated potassium channel 1753113 913101 ECs1750 Escherichia coli O157:H7 str. Sakai voltage-gated potassium channel NP_309777.1 1751860 R 386585 CDS NP_309778.2 162139797 913100 complement(1753414..1753710) 1 NC_002695.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 1753710 913100 ECs1751 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309778.2 1753414 R 386585 CDS NP_309779.1 15831006 913099 1753934..1754653 1 NC_002695.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1754653 913099 ECs1752 Escherichia coli O157:H7 str. Sakai transporter NP_309779.1 1753934 D 386585 CDS NP_309780.1 15831007 913098 complement(1754693..1755091) 1 NC_002695.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase 1755091 913098 ECs1753 Escherichia coli O157:H7 str. Sakai acyl-CoA thioester hydrolase NP_309780.1 1754693 R 386585 CDS NP_309781.1 15831008 913097 complement(1755196..1755735) 1 NC_002695.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1755735 913097 ECs1754 Escherichia coli O157:H7 str. Sakai intracellular septation protein A NP_309781.1 1755196 R 386585 CDS NP_309782.1 15831009 913096 complement(1755765..1756508) 1 NC_002695.1 similar to YCIC_ECOLI gi|1787508 (conserved in Escherichia coli K-12); hypothetical protein 1756508 913096 ECs1755 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309782.1 1755765 R 386585 CDS NP_309783.1 15831010 913095 1756865..1757503 1 NC_002695.1 receptor for colicin S4; outer membrane protein W 1757503 913095 ECs1756 Escherichia coli O157:H7 str. Sakai outer membrane protein W NP_309783.1 1756865 D 386585 CDS NP_309784.1 15831011 913094 complement(1757549..1758679) 1 NC_002695.1 similar to phage integrase [Bacteriophage 21] gi|138558|sp|P27077|VINT_BPP21; integrase 1758679 913094 ECs1757 Escherichia coli O157:H7 str. Sakai integrase NP_309784.1 1757549 R 386585 CDS NP_309785.1 15831012 913093 complement(1758657..1758905) 1 NC_002695.1 similar to excisionase [Bacteriophage 21] gi|139674|sp|P27079|VXIS_BPP21; excisionase 1758905 913093 ECs1758 Escherichia coli O157:H7 str. Sakai excisionase NP_309785.1 1758657 R 386585 CDS NP_309786.1 15831013 913091 complement(1758970..1761441) 1 NC_002695.1 similar to hypothetical protein ydfE [Escherichia coli cryptic prophage/truncated insertion sequence IS2 fusion] gi|78597|pir||S03698; exonuclease 1761441 913091 ECs1759 Escherichia coli O157:H7 str. Sakai exonuclease NP_309786.1 1758970 R 386585 CDS NP_309787.1 15831014 913090 complement(1761534..1761725) 1 NC_002695.1 similar to hypothetical protein YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein 1761725 913090 ECs1760 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309787.1 1761534 R 386585 CDS NP_309788.1 15831015 913089 complement(1761722..1761910) 1 NC_002695.1 similar to cell division inhibitor dicB [Escherichia coli] gi|2507009|sp|P09557|DICB_ECOLI; cell division inhibition protein; DicB 1761910 913089 ECs1761 Escherichia coli O157:H7 str. Sakai DicB NP_309788.1 1761722 R 386585 CDS NP_309789.1 15831016 913087 1762384..1762617 1 NC_002695.1 hypothetical protein 1762617 913087 ECs1762 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309789.1 1762384 D 386585 CDS NP_309790.1 15831017 913086 complement(1762595..1763002) 1 NC_002695.1 hypothetical protein 1763002 913086 ECs1763 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309790.1 1762595 R 386585 CDS NP_309791.1 15831018 913085 complement(1763025..1763243) 1 NC_002695.1 similar to hypothetical 8.3 KD protein YdfC [Escherichia coli] gi|140586|sp|P21418|YDFC_ECOLI; hypothetical protein 1763243 913085 ECs1764 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309791.1 1763025 R 386585 CDS NP_944527.1 38703953 2693743 complement(1763316..1763615) 1 NC_002695.1 hypothetical protein 1763615 2693743 ECs5428 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944527.1 1763316 R 386585 CDS NP_309792.1 15831019 913084 complement(1763879..1764286) 1 NC_002695.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1764286 913084 ECs1765 Escherichia coli O157:H7 str. Sakai transcriptional repressor DicA NP_309792.1 1763879 R 386585 CDS NP_309793.1 15831020 913083 1764363..1764590 1 NC_002695.1 probable repressor protein of division inhibition gene dicB; similar to DicC [Escherichia coli] gi|118633|sp|P06965|DICC_ECOLI; DNA-binding transcriptional regulator DicC 1764590 913083 ECs1766 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator DicC NP_309793.1 1764363 D 386585 CDS NP_309794.1 15831021 913082 1764574..1765125 1 NC_002695.1 similar to hypothetical 11.0 kDa protein YdfX [Escherichia coli] gi|3183265|sp|P76165|YDFX_ECOLI; hypothetical protein 1765125 913082 ECs1767 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309794.1 1764574 D 386585 CDS NP_309795.1 15831022 913081 1765097..1766137 1 NC_002695.1 similar to replication termination factor (prepriming protein I) DnaT [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein 1766137 913081 ECs1768 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309795.1 1765097 D 386585 CDS NP_309796.1 15831023 913080 1765926..1766591 1 NC_002695.1 similar to phage replication proteins e.g. protein 14 [phage phi-80] gi|137937|sp|P14814|VG14_BPPH8; phage replication protein 1766591 913080 ECs1769 Escherichia coli O157:H7 str. Sakai phage replication protein NP_309796.1 1765926 D 386585 CDS NP_309799.1 15831026 913076 1768219..1768977 1 NC_002695.1 similar to accessory colonization factor AcfC [Vibrio cholerae] gi|558481|gb|AAA50604.1, Anm (attachment and effacement of negative mutant) protein [Escherichia coli] gi|6715555|gb|AAB48445.2; colonization factor 1768977 913076 ECs1772 Escherichia coli O157:H7 str. Sakai colonization factor NP_309799.1 1768219 D 386585 CDS NP_309800.1 15831027 913074 1769256..1769468 1 NC_002695.1 probable toxic protein; similar to Hok/Gef family e.g. Gef [Escherichia coli] gi|2120017|pir||S40540; prophage maintenance protein 1769468 913074 ECs1773 Escherichia coli O157:H7 str. Sakai prophage maintenance protein NP_309800.1 1769256 D 386585 CDS NP_309801.1 15831028 913072 1769689..1769946 1 NC_002695.1 similar to Rem protein [Escherichia coli] gi|132324|sp|P07010|REM_ECOLI; hypothetical protein 1769946 913072 ECs1774 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309801.1 1769689 D 386585 CDS NP_309802.1 15831029 913071 1770016..1770294 1 NC_002695.1 similar to orf QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1; hypothetical protein 1770294 913071 ECs1775 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309802.1 1770016 D 386585 CDS NP_309803.1 15831030 913070 1770296..1771342 1 NC_002695.1 similar to hypothetical protein b1560 [Escherichia coli] gi|7466196|pir||C64911, hypothetical protein A [phage P1] gi|732234|sp|Q06262|YORA_BPP1; hypothetical protein 1771342 913070 ECs1776 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309803.1 1770296 D 386585 CDS NP_309804.1 15831031 913069 1771355..1771714 1 NC_002695.1 probable crossover junction endodeoxyribonuclease; similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1, crossover junction endodeoxyribonucleases e.g. Rus [Escherichia coli cryptic lambdoid prophage; endonuclease 1771714 913069 ECs1777 Escherichia coli O157:H7 str. Sakai endonuclease NP_309804.1 1771355 D 386585 CDS NP_309805.1 15831032 913068 1771723..1772253 1 NC_002695.1 hypothetical protein 1772253 913068 ECs1778 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309805.1 1771723 D 386585 CDS NP_309806.1 15831033 913067 1772372..1772692 1 NC_002695.1 similar to orf2 [Bacteriophage P27] gi|8346569|emb|CAB93762.1|; lipoprotein 1772692 913067 ECs1779 Escherichia coli O157:H7 str. Sakai lipoprotein NP_309806.1 1772372 D 386585 CDS NP_309807.1 15831034 913066 1772843..1773901 1 NC_002695.1 similar to orf3 [Bacteriophage P27] gi|8346570|emb|CAB93763.1, adenine specific modification methylases e.g. Gp52 [phage N15] gi|7433503|pir||T13139; DNA methylase 1773901 913066 ECs1780 Escherichia coli O157:H7 str. Sakai DNA methylase NP_309807.1 1772843 D 386585 CDS NP_309808.1 15831035 913049 1774698..1776551 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 1776551 913049 ECs1781 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309808.1 1774698 D 386585 CDS NP_309809.1 15831036 913047 1776701..1776916 1 NC_002695.1 similar to holin e.g. [Bacteriophage 933W] gi|4499808|emb|CAB39307.1; holin 1776916 913047 ECs1782 Escherichia coli O157:H7 str. Sakai holin NP_309809.1 1776701 D 386585 CDS NP_309810.1 15831037 913045 1776921..1777265 1 NC_002695.1 similar to hypothetical protein YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 1777265 913045 ECs1783 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309810.1 1776921 D 386585 CDS NP_309811.1 15831038 913044 1777316..1777849 1 NC_002695.1 similar to endolysins e.g. [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin 1777849 913044 ECs1784 Escherichia coli O157:H7 str. Sakai endolysin NP_309811.1 1777316 D 386585 CDS NP_309812.1 15831039 913041 1778120..1778689 1 NC_002695.1 similar to antirepressor protein Ant [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520, antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 1778689 913041 ECs1785 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_309812.1 1778120 D 386585 CDS NP_309813.1 15831040 913037 1778843..1779310 1 NC_002695.1 endopeptidase (host lysis); similar to Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1|, Rz endopeptidases e.g. [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 1779310 913037 ECs1786 Escherichia coli O157:H7 str. Sakai endopeptidase NP_309813.1 1778843 D 386585 CDS NP_309815.1 15831042 913028 complement(1779673..1779900) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein 1779900 913028 ECs1788 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309815.1 1779673 R 386585 CDS NP_309816.1 15831043 913025 1779942..1780307 1 NC_002695.1 similar to DNAse [Bacteriophage phi-C31] gi|1107475|emb|CAA62587.1; Dnase 1780307 913025 ECs1789 Escherichia coli O157:H7 str. Sakai Dnase NP_309816.1 1779942 D 386585 CDS NP_944528.1 38703954 2693744 complement(1779960..1780205) 1 NC_002695.1 hypothetical protein 1780205 2693744 ECs5431 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944528.1 1779960 R 386585 CDS NP_309818.1 15831045 912994 1780597..1781160 1 NC_002695.1 similar to terminase small subunit [Bacillus subtilis PBSX phage] gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 1781160 912994 ECs1791 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_309818.1 1780597 D 386585 CDS NP_309819.1 15831046 912990 1781157..1782818 1 NC_002695.1 similar to phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 1782818 912990 ECs1792 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_309819.1 1781157 D 386585 CDS NP_309820.1 15831047 912961 1782882..1784819 1 NC_002695.1 similar to prohead proteases e.g. [Bacteriophage HK97] gi|1722780|sp|P49860|VP4_BPHK7; major head protein/prohead protease 1784819 912961 ECs1793 Escherichia coli O157:H7 str. Sakai major head protein/prohead protease NP_309820.1 1782882 D 386585 CDS NP_309822.1 15831049 912946 1785031..1787610 1 NC_002695.1 similar to head portal proteins, e.g. [Bacteriophage HK022] gi|6863114|gb|AAF30355.1|AF069308_3; portal protein 1787610 912946 ECs1795 Escherichia coli O157:H7 str. Sakai portal protein NP_309822.1 1785031 D 386585 CDS NP_309823.1 15831050 912943 1787613..1787939 1 NC_002695.1 hypothetical protein 1787939 912943 ECs1796 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309823.1 1787613 D 386585 CDS NP_309824.1 15831051 912938 1787949..1788299 1 NC_002695.1 similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 1788299 912938 ECs1797 Escherichia coli O157:H7 str. Sakai head-tail adaptor NP_309824.1 1787949 D 386585 CDS NP_309825.1 15831052 912937 1788296..1788742 1 NC_002695.1 similar to phage hypothetical proteins e.g. Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 1788742 912937 ECs1798 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309825.1 1788296 D 386585 CDS NP_309826.1 15831053 912932 1788739..1789083 1 NC_002695.1 similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 1789083 912932 ECs1799 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309826.1 1788739 D 386585 CDS NP_309827.1 15831054 912931 1789013..1789858 1 NC_002695.1 similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail subunit 1789858 912931 ECs1800 Escherichia coli O157:H7 str. Sakai major tail subunit NP_309827.1 1789013 D 386585 CDS NP_309828.1 15831055 912930 1789864..1790238 1 NC_002695.1 similar to tail assembly chaperone Gp14 [Bacteriophage HK97] gi|6901600|gb|AAF31103.1; tail assembly chaperone 1790238 912930 ECs1801 Escherichia coli O157:H7 str. Sakai tail assembly chaperone NP_309828.1 1789864 D 386585 CDS NP_309829.1 15831056 912927 1790262..1790543 1 NC_002695.1 produced by translational frameshift; similar to C-terminal part of Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1|; hypothetical protein 1790543 912927 ECs1802 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309829.1 1790262 D 386585 CDS NP_309830.1 15831057 912925 1790596..1793676 1 NC_002695.1 similar to tail length tape measure proteins e.g. [Bacteriophage HK97] gi|6901589|gb|AAF31092.1|AF069529_5; tail length tape measure protein 1793676 912925 ECs1803 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_309830.1 1790596 D 386585 CDS NP_309831.1 15831058 912922 1793669..1794010 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1794010 912922 ECs1804 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309831.1 1793669 D 386585 CDS NP_309832.1 15831059 912921 1794010..1794447 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1794447 912921 ECs1805 Escherichia coli O157:H7 str. Sakai minor tail protein NP_309832.1 1794010 D 386585 CDS NP_309833.1 15831060 912919 1794635..1798111 1 NC_002695.1 similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1798111 912919 ECs1806 Escherichia coli O157:H7 str. Sakai host specificity protein NP_309833.1 1794635 D 386585 CDS NP_309834.1 15831061 912918 1798179..1798778 1 NC_002695.1 similar to outer membrane protein Lom precursors e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2, [Bacteriophage lambda] gi|138693|sp|P03701|VLOM_LAMBD; outer membrane protein 1798778 912918 ECs1807 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309834.1 1798179 D 386585 CDS NP_309835.1 15831062 912917 1798930..1800243 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 1800243 912917 ECs1808 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_309835.1 1798930 D 386585 CDS NP_309836.1 15831063 912916 1800245..1800514 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 1800514 912916 ECs1809 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309836.1 1800245 D 386585 CDS NP_309839.1 15831066 912909 complement(1801541..1802866) 1 NC_002695.1 hypothetical protein 1802866 912909 ECs1812 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309839.1 1801541 R 386585 CDS NP_309840.1 15831067 912908 complement(1803527..1804219) 1 NC_002695.1 similar to integrases e.g. [Bacteriophage HK022] gi|138560|sp|P16407|VINT_BPHK0; integrase 1804219 912908 ECs1813 Escherichia coli O157:H7 str. Sakai integrase NP_309840.1 1803527 R 386585 CDS NP_309841.1 15831068 912906 1804693..1805604 1 NC_002695.1 hypothetical protein 1805604 912906 ECs1814 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309841.1 1804693 D 386585 CDS NP_309842.1 15831069 912903 1805670..1806239 1 NC_002695.1 hypothetical protein 1806239 912903 ECs1815 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309842.1 1805670 D 386585 CDS NP_309845.1 15831072 912900 complement(1807205..1808743) 1 NC_002695.1 similar to L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 1808743 912900 ECs1818 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309845.1 1807205 R 386585 CDS NP_309846.1 15831073 912899 complement(1808793..1809140) 1 NC_002695.1 similar to L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1|; hypothetical protein 1809140 912899 ECs1819 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309846.1 1808793 R 386585 CDS NP_309847.1 15831074 912896 complement(1809137..1809517) 1 NC_002695.1 similar to L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1|; hypothetical protein 1809517 912896 ECs1820 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309847.1 1809137 R 386585 CDS NP_309848.1 15831075 912892 complement(1809857..1810135) 1 NC_002695.1 hypothetical protein 1810135 912892 ECs1821 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309848.1 1809857 R 386585 CDS NP_309851.1 15831078 912888 complement(1810846..1811493) 1 NC_002695.1 similar to hypothetical proteins e.g. orf2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1811493 912888 ECs1824 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309851.1 1810846 R 386585 CDS NP_309852.1 15831079 912883 1811677..1812267 1 NC_002695.1 similar to TrcA (bfpT-regulated chaperone-like protein) -like proteins e.g. TrcA [Escherichia coli strain B171-8] gi|4126789|dbj|BAA36747.1; bfpT-regulated chaperone-like protein 1812267 912883 ECs1825 Escherichia coli O157:H7 str. Sakai bfpT-regulated chaperone-like protein NP_309852.1 1811677 D 386585 CDS NP_309856.1 15831083 912873 complement(1815738..1816244) 1 NC_002695.1 similar to YCIE_ECOLI gi|1787511 (conserved in Escherichia coli K-12); hypothetical protein 1816244 912873 ECs1829 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309856.1 1815738 R 386585 CDS NP_309857.1 15831084 912869 complement(1816290..1816790) 1 NC_002695.1 similar to YCIF_ECOLI gi|1787512 (conserved in Escherichia coli K-12); hypothetical protein 1816790 912869 ECs1830 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309857.1 1816290 R 386585 CDS NP_309858.2 38703955 912863 complement(1816876..1817055) 1 NC_002695.1 similar to YCIG_ECOLI gi|1787513 (conserved in Escherichia coli K-12); hypothetical protein 1817055 912863 ECs1831 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309858.2 1816876 R 386585 CDS NP_309859.1 15831086 912862 complement(1817436..1818242) 1 NC_002695.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1818242 trpA 912862 trpA Escherichia coli O157:H7 str. Sakai tryptophan synthase subunit alpha NP_309859.1 1817436 R 386585 CDS NP_309860.1 15831087 912860 complement(1818242..1819435) 1 NC_002695.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1819435 912860 ECs1833 Escherichia coli O157:H7 str. Sakai tryptophan synthase subunit beta NP_309860.1 1818242 R 386585 CDS NP_309861.1 15831088 912854 complement(1819447..1820808) 1 NC_002695.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1820808 912854 ECs1834 Escherichia coli O157:H7 str. Sakai bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase NP_309861.1 1819447 R 386585 CDS NP_309862.1 15831089 912851 complement(1820809..1822404) 1 NC_002695.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1822404 912851 ECs1835 Escherichia coli O157:H7 str. Sakai bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase NP_309862.1 1820809 R 386585 CDS NP_309863.1 15831090 912849 complement(1822404..1823966) 1 NC_002695.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1823966 912849 ECs1836 Escherichia coli O157:H7 str. Sakai anthranilate synthase component I NP_309863.1 1822404 R 386585 CDS NP_309865.1 15831092 912844 1824240..1825121 1 NC_002695.1 similar to YCIV_ECOLI gi|1787520 (conserved in Escherichia coli K-12); hypothetical protein 1825121 912844 ECs1838 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309865.1 1824240 D 386585 CDS NP_309866.3 162139712 912843 1825082..1825738 1 NC_002695.1 similar to YCIO_ECOLI gi|1787521 (conserved in Escherichia coli K-12); hypothetical protein 1825738 912843 ECs1839 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309866.3 1825082 D 386585 CDS NP_309867.1 15831094 912840 1825766..1827349 1 NC_002695.1 similar to YCIQ_ECOLI gi|1787522, YCIQ_ECOLI gi|1787522; hypothetical protein 1827349 912840 ECs1840 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309867.1 1825766 D 386585 CDS NP_309868.1 15831095 912836 1827562..1828434 1 NC_002695.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1828434 912836 ECs1841 Escherichia coli O157:H7 str. Sakai 23S rRNA pseudouridylate synthase B NP_309868.1 1827562 D 386585 CDS NP_309869.1 15831096 912833 complement(1828474..1829064) 1 NC_002695.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1829064 912833 ECs1842 Escherichia coli O157:H7 str. Sakai cob(I)yrinic acid a,c-diamide adenosyltransferase NP_309869.1 1828474 R 386585 CDS NP_309870.1 15831097 912829 complement(1829061..1829819) 1 NC_002695.1 similar to YCIK_ECOLI gi|1787526 (conserved in Escherichia coli K-12); short chain dehydrogenase 1829819 912829 ECs1843 Escherichia coli O157:H7 str. Sakai short chain dehydrogenase NP_309870.1 1829061 R 386585 CDS NP_309871.1 15831098 912827 1830039..1831088 1 NC_002695.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1831088 912827 ECs1844 Escherichia coli O157:H7 str. Sakai periplasmic protease NP_309871.1 1830039 D 386585 CDS NP_309872.1 15831099 912821 complement(1831124..1831375) 1 NC_002695.1 similar to YCIN_ECOLI gi|1787528 (conserved in Escherichia coli K-12); hypothetical protein 1831375 912821 ECs1845 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309872.1 1831124 R 386585 CDS NP_309873.1 15831100 912819 1831755..1834352 1 NC_002695.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1834352 912819 ECs1846 Escherichia coli O157:H7 str. Sakai DNA topoisomerase I NP_309873.1 1831755 D 386585 CDS NP_309874.1 15831101 912818 1834562..1835536 1 NC_002695.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1835536 cysB 912818 cysB Escherichia coli O157:H7 str. Sakai transcriptional regulator CysB NP_309874.1 1834562 D 386585 CDS NP_309876.1 15831103 912815 1836538..1839213 1 NC_002695.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1839213 912815 ECs1849 Escherichia coli O157:H7 str. Sakai aconitate hydratase NP_309876.1 1836538 D 386585 CDS NP_309877.1 15831104 912813 complement(1839277..1839867) 1 NC_002695.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1839867 ribA 912813 ribA Escherichia coli O157:H7 str. Sakai GTP cyclohydrolase II NP_309877.1 1839277 R 386585 CDS NP_309878.1 15831105 912812 1840037..1840801 1 NC_002695.1 similar to PGPB_ECOLI gi|1787534 (conserved in Escherichia coli K-12); phosphatidylglycerophosphatase B 1840801 912812 ECs1851 Escherichia coli O157:H7 str. Sakai phosphatidylglycerophosphatase B NP_309878.1 1840037 D 386585 CDS NP_309879.1 15831106 912811 1840950..1841258 1 NC_002695.1 similar to YCIS_ECOLI gi|1787535 (conserved in Escherichia coli K-12); hypothetical protein 1841258 912811 ECs1852 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309879.1 1840950 D 386585 CDS NP_309880.1 15831107 912810 1841265..1842434 1 NC_002695.1 similar to YCIM_ECOLI gi|2367116 (conserved in Escherichia coli K-12); tetratricopeptide repeat protein 1842434 912810 ECs1853 Escherichia coli O157:H7 str. Sakai tetratricopeptide repeat protein NP_309880.1 1841265 D 386585 CDS NP_309881.1 15831108 912806 1842627..1843364 1 NC_002695.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1843364 912806 ECs1854 Escherichia coli O157:H7 str. Sakai orotidine 5'-phosphate decarboxylase NP_309881.1 1842627 D 386585 CDS NP_309882.1 15831109 912805 1843361..1843690 1 NC_002695.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1843690 912805 ECs1855 Escherichia coli O157:H7 str. Sakai translation initiation factor Sui1 NP_309882.1 1843361 D 386585 CDS NP_309883.1 15831110 912802 complement(1843816..1844034) 1 NC_002695.1 similar to OSMB_ECOLI gi|1787539 (conserved in Escherichia coli K-12); lipoprotein 1844034 912802 ECs1856 Escherichia coli O157:H7 str. Sakai lipoprotein NP_309883.1 1843816 R 386585 CDS NP_309884.1 15831111 912796 complement(1844303..1845052) 1 NC_002695.1 similar to B1284_ECOLI gi|1787540 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 1845052 912796 ECs1857 Escherichia coli O157:H7 str. Sakai DeoR family transcriptional regulator NP_309884.1 1844303 R 386585 CDS NP_944529.1 38703957 2693803 complement(1845142..1845315) 1 NC_002695.1 hypothetical protein 1845315 2693803 ECs5432 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944529.1 1845142 R 386585 CDS NP_309885.1 15831112 912794 complement(1845463..1847448) 1 NC_002695.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1847448 912794 ECs1858 Escherichia coli O157:H7 str. Sakai RNase II stability modulator NP_309885.1 1845463 R 386585 CDS NP_309886.1 15831113 912791 complement(1847683..1849617) 1 NC_002695.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1849617 912791 ECs1859 Escherichia coli O157:H7 str. Sakai exoribonuclease II NP_309886.1 1847683 R 386585 CDS NP_309887.2 162139796 912788 complement(1849685..1850812) 1 NC_002695.1 similar to YCIW_ECOLI gi|1787544 (conserved in Escherichia coli K-12); oxidoreductase 1850812 912788 ECs1860 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_309887.2 1849685 R 386585 CDS NP_309888.1 15831115 912787 complement(1850956..1851744) 1 NC_002695.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1851744 912787 ECs1861 Escherichia coli O157:H7 str. Sakai enoyl-ACP reductase NP_309888.1 1850956 R 386585 CDS NP_309889.1 15831116 912785 1852222..1852788 1 NC_002695.1 similar to transcription regulatory proteins e.g. UidR [Escherichia coli] gi|2495429|sp|Q59431|UIDR_ECOLI; transcription regulatory protein 1852788 912785 ECs1862 Escherichia coli O157:H7 str. Sakai transcription regulatory protein NP_309889.1 1852222 D 386585 CDS NP_309890.1 15831117 912781 1852937..1854058 1 NC_002695.1 similar to multidrug-efflux transport protein precursors e.g. AcrA [Escherichia coli K-12] gi|399000|sp|P31223|ACRA_ECOLI; multidrug-efflux transport protein 1854058 912781 ECs1863 Escherichia coli O157:H7 str. Sakai multidrug-efflux transport protein NP_309890.1 1852937 D 386585 CDS NP_309891.1 15831118 912777 1854058..1857141 1 NC_002695.1 similar to multidrug-efflux transport proteins e.g. AcrB [Escherichia coli K-12] gi|399001|sp|P31224|ACRB_ECOLI; multidrug-efflux transport protein 1857141 912777 ECs1864 Escherichia coli O157:H7 str. Sakai multidrug-efflux transport protein NP_309891.1 1854058 D 386585 CDS NP_309892.1 15831119 912775 1857164..1858537 1 NC_002695.1 similar to outer membrane channel proteins e.g. OprM [Pseudomonas aeruginosa] gi|3184190|dbj|BAA28694.1; outer membrane channel protein 1858537 912775 ECs1865 Escherichia coli O157:H7 str. Sakai outer membrane channel protein NP_309892.1 1857164 D 386585 CDS NP_309893.1 15831120 912751 1858546..1859709 1 NC_002695.1 similar to membrane transport proteins e.g. [Streptomyces coelicolor A3(2)] gi|6469269|emb|CAB61730.1; membrane transport protein 1859709 912751 ECs1866 Escherichia coli O157:H7 str. Sakai membrane transport protein NP_309893.1 1858546 D 386585 CDS NP_309894.1 15831121 912744 complement(1859761..1860567) 1 NC_002695.1 similar to SAPF_ECOLI gi|1787547 (conserved in Escherichia coli K-12); peptide ABC transporter ATP-binding protein 1860567 912744 ECs1867 Escherichia coli O157:H7 str. Sakai peptide ABC transporter ATP-binding protein NP_309894.1 1859761 R 386585 CDS NP_309895.1 15831122 912736 complement(1860569..1861561) 1 NC_002695.1 similar to SAPD_ECOLI gi|1787548 (conserved in Escherichia coli K-12); peptide ABC transporter ATP-binding protein 1861561 912736 ECs1868 Escherichia coli O157:H7 str. Sakai peptide ABC transporter ATP-binding protein NP_309895.1 1860569 R 386585 CDS NP_309896.1 15831123 912734 complement(1861561..1862451) 1 NC_002695.1 similar to SAPC_ECOLI gi|1787549 (conserved in Escherichia coli K-12); peptide transport permease 1862451 912734 ECs1869 Escherichia coli O157:H7 str. Sakai peptide transport permease NP_309896.1 1861561 R 386585 CDS NP_309897.1 15831124 912731 complement(1862438..1863403) 1 NC_002695.1 similar to SAPB_ECOLI gi|1787550 (conserved in Escherichia coli K-12); peptide transport permease 1863403 912731 ECs1870 Escherichia coli O157:H7 str. Sakai peptide transport permease NP_309897.1 1862438 R 386585 CDS NP_309898.1 15831125 912723 complement(1863400..1865043) 1 NC_002695.1 periplasmic protein; similar to SAPA_ECOLI gi|1787551 (conserved in Escherichia coli K-12); peptide transport-like protein 1865043 912723 ECs1871 Escherichia coli O157:H7 str. Sakai peptide transport-like protein NP_309898.1 1863400 R 386585 CDS NP_309899.1 15831126 912721 complement(1865356..1865601) 1 NC_002695.1 similar to YMJA_ECOLI gi|1787552 (conserved in Escherichia coli K-12); hypothetical protein 1865601 912721 ECs1872 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309899.1 1865356 R 386585 CDS NP_309900.2 38703958 912717 complement(1865735..1867120) 1 NC_002695.1 similar to YCJJ_ECOLI gi|1787553 (conserved in Escherichia coli K-12); amino acid/amine transport protein 1867120 912717 ECs1873 Escherichia coli O157:H7 str. Sakai amino acid/amine transport protein NP_309900.2 1865735 R 386585 CDS NP_309901.2 38703959 912703 complement(1867423..1868841) 1 NC_002695.1 similar to B1297_ECOLI gi|1787555 (conserved in Escherichia coli K-12); glutamine synthetase 1868841 912703 ECs1874 Escherichia coli O157:H7 str. Sakai glutamine synthetase NP_309901.2 1867423 R 386585 CDS NP_309902.2 38703960 912701 1869053..1869817 1 NC_002695.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1869817 puuD 912701 puuD Escherichia coli O157:H7 str. Sakai gamma-glutamyl-gamma-aminobutyrate hydrolase NP_309902.2 1869053 D 386585 CDS NP_309903.1 15831130 912699 1869844..1870401 1 NC_002695.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1870401 912699 ECs1876 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor PuuR NP_309903.1 1869844 D 386585 CDS NP_309904.1 15831131 912694 1870551..1872038 1 NC_002695.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1872038 912694 ECs1877 Escherichia coli O157:H7 str. Sakai gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase NP_309904.1 1870551 D 386585 CDS NP_309905.1 15831132 912689 1872040..1873320 1 NC_002695.1 similar to ORDL_ECOLI gi|1787559 (conserved in Escherichia coli K-12); oxidoreductase 1873320 912689 ECs1878 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_309905.1 1872040 D 386585 CDS NP_309906.1 15831133 912688 1873358..1874623 1 NC_002695.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1874623 912688 ECs1879 Escherichia coli O157:H7 str. Sakai 4-aminobutyrate aminotransferase NP_309906.1 1873358 D 386585 CDS NP_309907.2 38703961 912687 complement(1874754..1875731) 1 NC_002695.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1875731 pspF 912687 pspF Escherichia coli O157:H7 str. Sakai phage shock protein operon transcriptional activator NP_309907.2 1874754 R 386585 CDS NP_309908.1 15831135 912684 1875898..1876566 1 NC_002695.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1876566 912684 ECs1881 Escherichia coli O157:H7 str. Sakai phage shock protein PspA NP_309908.1 1875898 D 386585 CDS NP_309909.1 15831136 912683 1876620..1876844 1 NC_002695.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1876844 pspB 912683 pspB Escherichia coli O157:H7 str. Sakai phage shock protein B NP_309909.1 1876620 D 386585 CDS NP_309910.1 15831137 912672 1876844..1877203 1 NC_002695.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; PspC family transcriptional regulator 1877203 912672 ECs1883 Escherichia coli O157:H7 str. Sakai PspC family transcriptional regulator NP_309910.1 1876844 D 386585 CDS NP_309911.1 15831138 912668 1877212..1877433 1 NC_002695.1 similar to PSPD_ECOLI gi|1787565 (conserved in Escherichia coli K-12); peripheral inner membrane phage-shock protein 1877433 912668 ECs1884 Escherichia coli O157:H7 str. Sakai peripheral inner membrane phage-shock protein NP_309911.1 1877212 D 386585 CDS NP_309912.1 15831139 912667 1877508..1877822 1 NC_002695.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1877822 912667 ECs1885 Escherichia coli O157:H7 str. Sakai thiosulfate:cyanide sulfurtransferase NP_309912.1 1877508 D 386585 CDS NP_309917.1 15831144 912626 1881037..1881918 1 NC_002695.1 similar to YCJO_ECOLI gi|1787570 (conserved in Escherichia coli K-12); binding-protein dependent transport protein 1881918 912626 ECs1890 Escherichia coli O157:H7 str. Sakai binding-protein dependent transport protein NP_309917.1 1881037 D 386585 CDS NP_309918.1 15831145 912625 1881905..1882747 1 NC_002695.1 similar to YCJP_ECOLI gi|1787571 (conserved in Escherichia coli K-12); transport system permease 1882747 912625 ECs1891 Escherichia coli O157:H7 str. Sakai transport system permease NP_309918.1 1881905 D 386585 CDS NP_309919.1 15831146 912623 1882778..1883830 1 NC_002695.1 similar to YCJQ_ECOLI gi|1787572 (conserved in Escherichia coli K-12); oxidoreductase 1883830 912623 ECs1892 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_309919.1 1882778 D 386585 CDS NP_309920.1 15831147 912614 1883848..1884636 1 NC_002695.1 similar to B1314_ECOLI gi|1787573 (conserved in Escherichia coli K-12); hypothetical protein 1884636 912614 ECs1893 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309920.1 1883848 D 386585 CDS NP_309921.1 15831148 912546 1884646..1885701 1 NC_002695.1 similar to YCJS_ECOLI gi|1787574 (conserved in Escherichia coli K-12); dehydrogenase 1885701 912546 ECs1894 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_309921.1 1884646 D 386585 CDS NP_309922.1 15831149 912526 1885698..1887965 1 NC_002695.1 similar to YCJT_ECOLI gi|1787575 (conserved in Escherichia coli K-12); hypothetical protein 1887965 912526 ECs1895 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309922.1 1885698 D 386585 CDS NP_309923.1 15831150 912522 1887962..1888621 1 NC_002695.1 similar to YCJU_ECOLI gi|1787576 (conserved in Escherichia coli K-12); beta-phosphoglucomutase 1888621 912522 ECs1896 Escherichia coli O157:H7 str. Sakai beta-phosphoglucomutase NP_309923.1 1887962 D 386585 CDS NP_309924.1 15831151 912514 1888635..1889717 1 NC_002695.1 similar to ABC transporter ATP-binding protein YCJV_ECOLI gi|1787577 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 1889717 912514 ECs1897 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_309924.1 1888635 D 386585 CDS NP_309925.1 15831152 912504 1889762..1890667 1 NC_002695.1 similar to OMPG_ECOLI gi|1787579 (conserved in Escherichia coli K-12); outer membrane protein 1890667 912504 ECs1898 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_309925.1 1889762 D 386585 CDS NP_309926.1 15831153 912493 complement(1890778..1891776) 1 NC_002695.1 similar to YCJW_ECOLI gi|1787580 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator 1891776 912493 ECs1899 Escherichia coli O157:H7 str. Sakai LACI-type transcriptional regulator NP_309926.1 1890778 R 386585 CDS NP_309927.1 15831154 912488 1891931..1893328 1 NC_002695.1 similar to YCJX_ECOLI gi|1787581 (conserved in Escherichia coli K-12); hypothetical protein 1893328 912488 ECs1900 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309927.1 1891931 D 386585 CDS NP_309928.1 15831155 912484 1893325..1894386 1 NC_002695.1 similar to YCJF_ECOLI gi|1787582 (conserved in Escherichia coli K-12); hypothetical protein 1894386 912484 ECs1901 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309928.1 1893325 D 386585 CDS NP_309929.1 15831156 912481 1894534..1896075 1 NC_002695.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1896075 912481 ECs1902 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator TyrR NP_309929.1 1894534 D 386585 CDS NP_309930.1 15831157 912478 complement(1896119..1896625) 1 NC_002695.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1896625 tpx 912478 tpx Escherichia coli O157:H7 str. Sakai thiol peroxidase NP_309930.1 1896119 R 386585 CDS NP_309931.2 38703962 912460 1896744..1897709 1 NC_002695.1 similar to YCJG_ECOLI gi|1787585 (conserved in Escherichia coli K-12); muconate cycloisomerase I 1897709 912460 ECs1904 Escherichia coli O157:H7 str. Sakai muconate cycloisomerase I NP_309931.2 1896744 D 386585 CDS NP_309932.1 15831159 912455 complement(1897684..1898472) 1 NC_002695.1 similar to YCJI_ECOLI gi|1787586 (conserved in Escherichia coli K-12); murein peptide amidase A 1898472 912455 ECs1905 Escherichia coli O157:H7 str. Sakai murein peptide amidase A NP_309932.1 1897684 R 386585 CDS NP_309933.2 38703963 912442 complement(1898703..1899353) 1 NC_002695.1 similar to hypothetical protein [Xylella fastidiosa] gi|9106817|gb|AAF84556.1|AE003997_12; hypothetical protein 1899353 912442 ECs1906 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309933.2 1898703 R 386585 CDS NP_309936.1 15831163 912427 complement(1900292..1901224) 1 NC_002695.1 similar to B1327_ECOLI gi|1787587 (conserved in Escherichia coli K-12); hypothetical protein 1901224 912427 ECs1909 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309936.1 1900292 R 386585 CDS NP_309937.1 15831164 912423 1901350..1902249 1 NC_002695.1 similar to YCJZ_ECOLI gi|1787589 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 1902249 912423 ECs1910 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_309937.1 1901350 D 386585 CDS NP_309938.2 38703964 912407 1902585..1904198 1 NC_002695.1 similar to B1329_ECOLI gi|1787590 (conserved in Escherichia coli K-12); transport periplasmic protein 1904198 912407 ECs1911 Escherichia coli O157:H7 str. Sakai transport periplasmic protein NP_309938.2 1902585 D 386585 CDS NP_309939.1 15831166 912403 complement(1904249..1905280) 1 NC_002695.1 similar to B1330_ECOLI gi|1787591 (conserved in Escherichia coli K-12); hypothetical protein 1905280 912403 ECs1912 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309939.1 1904249 R 386585 CDS NP_309940.1 15831167 912396 1905524..1905781 1 NC_002695.1 similar to YNAJ_ECOLI gi|1787593 (conserved in Escherichia coli K-12); hypothetical protein 1905781 912396 ECs1913 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309940.1 1905524 D 386585 CDS NP_309941.1 15831168 912394 complement(1905831..1906781) 1 NC_002695.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1906781 912394 ECs1914 Escherichia coli O157:H7 str. Sakai universal stress protein UspE NP_309941.1 1905831 R 386585 CDS NP_309942.1 15831169 912392 complement(1906933..1907685) 1 NC_002695.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1907685 912392 ECs1915 Escherichia coli O157:H7 str. Sakai fumarate/nitrate reduction transcriptional regulator NP_309942.1 1906933 R 386585 CDS NP_309943.1 15831170 912389 complement(1907880..1908395) 1 NC_002695.1 similar to OGT_ECOLI gi|1787596 (conserved in Escherichia coli K-12); O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1908395 912389 ECs1916 Escherichia coli O157:H7 str. Sakai O-6-alkylguanine-DNA:cysteine-protein methyltransferase NP_309943.1 1907880 R 386585 CDS NP_309944.1 15831171 912380 complement(1908406..1909020) 1 NC_002695.1 similar to C-terminal part (307-510 in 510 aa) of pump protein YDAH_ECOLI gi|1787597; hypothetical protein 1909020 912380 ECs1917 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309944.1 1908406 R 386585 CDS NP_309945.1 15831172 912376 complement(1909209..1910099) 1 NC_002695.1 OrfB; transposase of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 1910099 912376 ECs1918 Escherichia coli O157:H7 str. Sakai transposase NP_309945.1 1909209 R 386585 CDS NP_309946.1 15831173 912364 complement(1910096..1910422) 1 NC_002695.1 OrfA; transposase of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase 1910422 912364 ECs1919 Escherichia coli O157:H7 str. Sakai transposase NP_309946.1 1910096 R 386585 CDS NP_309947.1 15831174 912359 complement(1910448..1911245) 1 NC_002695.1 similar to YDAH_ECOLI gi|1787597; may be truncated; pump protein 1911245 912359 ECs1920 Escherichia coli O157:H7 str. Sakai pump protein NP_309947.1 1910448 R 386585 CDS NP_309948.1 15831175 912350 complement(1911282..1912727) 1 NC_002695.1 similar to B1337_ECOLI gi|1787598 (conserved in Escherichia coli K-12); hypothetical protein 1912727 912350 ECs1921 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309948.1 1911282 R 386585 CDS NP_309949.2 38703965 912338 complement(1912727..1914037) 1 NC_002695.1 similar to YDAJ_ECOLI gi|1787599 (conserved in Escherichia coli K-12); aminohydrolase 1914037 912338 ECs1922 Escherichia coli O157:H7 str. Sakai aminohydrolase NP_309949.2 1912727 R 386585 CDS NP_309950.1 15831177 912331 1914213..1915121 1 NC_002695.1 similar to YDAK_ECOLI gi|1787601 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 1915121 912331 ECs1923 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_309950.1 1914213 D 386585 CDS NP_309951.1 15831178 912328 1915451..1916014 1 NC_002695.1 similar to YDAL_ECOLI gi|1787602 (conserved in Escherichia coli K-12); hypothetical protein 1916014 912328 ECs1924 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309951.1 1915451 D 386585 CDS NP_309952.1 15831179 912323 complement(1916035..1917327) 1 NC_002695.1 similar to B1341_ECOLI gi|1787603 (conserved in Escherichia coli K-12); hypothetical protein 1917327 912323 ECs1925 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309952.1 1916035 R 386585 CDS NP_309953.1 15831180 912321 1917522..1918505 1 NC_002695.1 similar to B1342_ECOLI gi|1787604 (conserved in Escherichia coli K-12); zinc transporter 1918505 zntB 912321 zntB Escherichia coli O157:H7 str. Sakai zinc transporter NP_309953.1 1917522 D 386585 CDS NP_309954.1 15831181 912313 1918983..1920356 1 NC_002695.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1920356 912313 ECs1927 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase DbpA NP_309954.1 1918983 D 386585 CDS NP_309955.1 15831182 912308 complement(1920485..1921420) 1 NC_002695.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1921420 912308 ECs1928 Escherichia coli O157:H7 str. Sakai C32 tRNA thiolase NP_309955.1 1920485 R 386585 CDS NP_309956.1 15831183 912302 complement(1921472..1922707) 1 NC_002695.1 similar to B1345_ECOLI gi|1787607 (conserved in Escherichia coli K-12); transposase 1922707 912302 ECs1929 Escherichia coli O157:H7 str. Sakai transposase NP_309956.1 1921472 R 386585 CDS NP_309957.2 38703966 912301 complement(1922709..1922924) 1 NC_002695.1 similar to YDAQ_ECOLI gi|1787608 (conserved in Escherichia coli K-12); hypothetical protein 1922924 912301 ECs1930 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309957.2 1922709 R 386585 CDS NP_309958.1 15831185 912300 complement(1923024..1923212) 1 NC_002695.1 Rac prophage; hypothetical protein 1923212 912300 ECs1931 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309958.1 1923024 R 386585 CDS NP_309959.1 15831186 912297 complement(1923250..1923399) 1 NC_002695.1 seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage; restriction alleviation and modification protein 1923399 lar 912297 lar Escherichia coli O157:H7 str. Sakai restriction alleviation and modification protein NP_309959.1 1923250 R 386585 CDS NP_309960.1 15831187 912294 complement(1923455..1924264) 1 NC_002695.1 similar to RECT_ECOLI gi|1787611 (conserved in Escherichia coli K-12); recombination and repair protein RecT 1924264 recT 912294 recT Escherichia coli O157:H7 str. Sakai recombination and repair protein RecT NP_309960.1 1923455 R 386585 CDS NP_309961.1 15831188 912288 complement(1924257..1926857) 1 NC_002695.1 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC.; exonuclease VIII 1926857 912288 ECs1934 Escherichia coli O157:H7 str. Sakai exonuclease VIII NP_309961.1 1924257 R 386585 CDS NP_309962.1 15831189 917139 complement(1926959..1927234) 1 NC_002695.1 Rac prophage hypothetical protein; hypothetical protein 1927234 917139 ECs1935 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309962.1 1926959 R 386585 CDS NP_944530.1 38703967 2693825 complement(1927309..1927485) 1 NC_002695.1 hypothetical protein 1927485 2693825 ECs5433 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944530.1 1927309 R 386585 CDS NP_309963.1 15831190 917140 complement(1927479..1927712) 1 NC_002695.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein 1927712 kil 917140 kil Escherichia coli O157:H7 str. Sakai FtsZ inhibitor protein NP_309963.1 1927479 R 386585 CDS NP_309964.2 38703968 917383 1928142..1928630 1 NC_002695.1 similar to SIEB_ECOLI gi|1787616 (conserved in Escherichia coli K-12); phage superinfection exclusion protein 1928630 917383 ECs1937 Escherichia coli O157:H7 str. Sakai phage superinfection exclusion protein NP_309964.2 1928142 D 386585 CDS NP_309965.1 15831192 917660 complement(1928627..1928782) 1 NC_002695.1 similar to YDAF_ECOLI in sieB-racR intergenic region gi|3915965|sp|P38395 (not identified but conserved in K-12); hypothetical protein 1928782 917660 ECs1939 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309965.1 1928627 R 386585 CDS NP_309967.1 15831194 917587 complement(1928793..1928972) 1 NC_002695.1 similar to B1355_ECOLI gi|1787618 (conserved in Escherichia coli K-12); hypothetical protein 1928972 917587 ECs1940 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309967.1 1928793 R 386585 CDS NP_309968.1 15831195 917511 complement(1929215..1929526) 1 NC_002695.1 similar to regulatory proteins e.g. regulatory protein CI (235 aa) [Bacteriophage HK022] gi|1350835|sp|P18680; transcriptional regulator 1929526 917511 ECs1941 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_309968.1 1929215 R 386585 CDS NP_309969.1 15831196 917782 1929714..1929968 1 NC_002695.1 similar to Cro [Bacteriophage HK022] gi|1350553|sp|P18679; regulatory protein 1929968 917782 ECs1942 Escherichia coli O157:H7 str. Sakai regulatory protein NP_309969.1 1929714 D 386585 CDS NP_309970.1 15831197 917141 1929965..1930387 1 NC_002695.1 similar to YDAT_ECOLI gi|1787621 (conserved in Escherichia coli K-12); hypothetical protein 1930387 917141 ECs1943 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309970.1 1929965 D 386585 CDS NP_309971.1 15831198 917723 1930465..1931253 1 NC_002695.1 similar to YDAU_ECOLI gi|1787622; hypothetical protein 1931253 917723 ECs1944 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309971.1 1930465 D 386585 CDS NP_309972.1 15831199 917146 1931260..1932006 1 NC_002695.1 acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 1932006 917146 ECs1945 Escherichia coli O157:H7 str. Sakai replication protein NP_309972.1 1931260 D 386585 CDS NP_309973.1 15831200 917244 1931978..1932790 1 NC_002695.1 similar to YDAW_ECOLI gi|1787624; hypothetical protein 1932790 917244 ECs1946 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309973.1 1931978 D 386585 CDS NP_309975.1 15831202 917148 1932806..1933228 1 NC_002695.1 hypothetical protein 1933228 917148 ECs1948 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309975.1 1932806 D 386585 CDS NP_309976.1 15831203 917163 1933334..1933546 1 NC_002695.1 hypothetical protein 1933546 917163 ECs1949 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309976.1 1933334 D 386585 CDS NP_309977.1 15831204 917143 1933798..1934061 1 NC_002695.1 hypothetical protein 1934061 917143 ECs1950 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309977.1 1933798 D 386585 CDS NP_309978.1 15831205 917144 1934072..1934233 1 NC_002695.1 similar to EaA protein [Bacteriophage P22] gi|418207|sp|Q03544|VEAA_BPP22; hypothetical protein 1934233 917144 ECs1951 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309978.1 1934072 D 386585 CDS NP_309979.1 15831206 917147 1934312..1934557 1 NC_002695.1 similar to hypothetical protein [Bacteriophage H19J] gi|4490348|emb|CAB38711.1, Gp45 [Bacteriophage N15] gi|7521552|pir||T13131; hypothetical protein 1934557 917147 ECs1952 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309979.1 1934312 D 386585 CDS NP_309980.1 15831207 917152 1934989..1936140 1 NC_002695.1 similar to methyltransferases e.g. cytosine-specific methyltransferase XorII [Xanthomonas oryzae pv.] gi|1709171|sp|P52311|MTX2_XANOR; methyltransferase 1936140 917152 ECs1953 Escherichia coli O157:H7 str. Sakai methyltransferase NP_309980.1 1934989 D 386585 CDS NP_309981.1 15831208 917149 complement(1936108..1937097) 1 NC_002695.1 similar to hypothetical protein HI0983 [Haemophilus influenzae] gi|1074592|pir||D64163; hypothetical protein 1937097 917149 ECs1954 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309981.1 1936108 R 386585 CDS NP_309982.1 15831209 917150 complement(1937097..1938488) 1 NC_002695.1 hypothetical protein 1938488 917150 ECs1955 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309982.1 1937097 R 386585 CDS NP_309983.1 15831210 917151 1938988..1939587 1 NC_002695.1 similar to Orf79 [Bacteriophage D3] gi|8895177|gb|AAF80835.1; hypothetical protein 1939587 917151 ECs1956 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309983.1 1938988 D 386585 CDS NP_309984.1 15831211 917153 1939587..1939877 1 NC_002695.1 similar to hypothetical proteins e.g. YbcO [Escherichia coli cryptic prophage DLP12] gi|7467043|pir||C64787, Gp66 [Bacteriophage HK97] gi|6901638|gb|AAF31141.1; hypothetical protein 1939877 917153 ECs1957 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309984.1 1939587 D 386585 CDS NP_309985.1 15831212 917154 1939874..1940428 1 NC_002695.1 similar to antiterminator protein Q [Bacteriophage 21] gi|4539484|emb|CAB39993.1; antitermination protein 1940428 917154 ECs1958 Escherichia coli O157:H7 str. Sakai antitermination protein NP_309985.1 1939874 D 386585 CDS NP_309986.1 15831213 917159 1940990..1941421 1 NC_002695.1 similar to probable TerB proteins e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein 1941421 917159 ECs1959 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309986.1 1940990 D 386585 CDS NP_309987.1 15831214 917158 1941418..1941585 1 NC_002695.1 hypothetical protein 1941585 917158 ECs1960 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309987.1 1941418 D 386585 CDS NP_309988.1 15831215 917160 1941996..1943849 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 1943849 917160 ECs1961 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309988.1 1941996 D 386585 CDS NP_309989.1 15831216 917161 1943999..1944214 1 NC_002695.1 host cell lysis; similar to holins e.g. [Bacteriophage 933W] gi|4499808|emb|CAB39307.1; holin 1944214 917161 ECs1962 Escherichia coli O157:H7 str. Sakai holin NP_309989.1 1943999 D 386585 CDS NP_309990.1 15831217 917164 1944219..1944563 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 1944563 917164 ECs1963 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309990.1 1944219 D 386585 CDS NP_309991.1 15831218 917162 1944614..1945147 1 NC_002695.1 host cell lysis; similar to endolysins e.g. [Bacteriophage 933W] gi|4335686|gb|AAD17382.1; endolysin 1945147 917162 ECs1964 Escherichia coli O157:H7 str. Sakai endolysin NP_309991.1 1944614 D 386585 CDS NP_309992.1 15831219 917172 1945418..1945987 1 NC_002695.1 similar to antirepressor [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor protein Ant [Bacteriophage P22] gi|131843|sp|P0; antirepressor protein 1945987 917172 ECs1965 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_309992.1 1945418 D 386585 CDS NP_309993.1 15831220 917168 1946141..1946608 1 NC_002695.1 host cell lysis; similar to endopeptidases e.g. [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1; endopeptidase 1946608 917168 ECs1966 Escherichia coli O157:H7 str. Sakai endopeptidase NP_309993.1 1946141 D 386585 CDS NP_309994.1 15831221 917167 complement(1946971..1947198) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1, hypothetical protein [Salmonella dublin] gi|3511132|gb|AAC33722.1; hypothetical protein 1947198 917167 ECs1967 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_309994.1 1946971 R 386585 CDS NP_309995.1 15831222 917166 1947240..1947605 1 NC_002695.1 similar to TerF-related protein [Deinococcus radiodurans] gi|7473956|pir||C75599, gp30 (DNase) [Bacteriophage phi-C31] gi|1107475|emb|CAA62587.1; DNase 1947605 917166 ECs1968 Escherichia coli O157:H7 str. Sakai DNase NP_309995.1 1947240 D 386585 CDS NP_944531.1 38703969 2693804 complement(1947258..1947503) 1 NC_002695.1 hypothetical protein 1947503 2693804 ECs5437 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944531.1 1947258 R 386585 CDS NP_309997.1 15831224 917180 1947895..1948458 1 NC_002695.1 similar to phage terminase small subunits e.g. [Bacillus subtilis PBSX] gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 1948458 917180 ECs1970 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_309997.1 1947895 D 386585 CDS NP_309998.1 15831225 917171 1948455..1950116 1 NC_002695.1 similar to phage hypothetical proteins, e.g. phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 1950116 917171 ECs1971 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_309998.1 1948455 D 386585 CDS NP_309999.1 15831226 917173 1950180..1952117 1 NC_002695.1 similar to major head proteins e.g. [Mycobacterium phage L5] gi|465114|sp|Q05223|VG17_BPML5; phage major head protein/prohead protease 1952117 917173 ECs1972 Escherichia coli O157:H7 str. Sakai phage major head protein/prohead protease NP_309999.1 1950180 D 386585 CDS NP_944532.1 38703970 2693805 1952162..1952383 1 NC_002695.1 hypothetical protein 1952383 2693805 ECs5438 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944532.1 1952162 D 386585 CDS NP_310001.1 15831228 917170 1952329..1953693 1 NC_002695.1 similar to phage portal proteins e.g. [Bacteriophage D3] gi|5059250|gb|AAD38955.1; portal protein 1953693 917170 ECs1974 Escherichia coli O157:H7 str. Sakai portal protein NP_310001.1 1952329 D 386585 CDS NP_310002.1 15831229 917175 1953690..1954913 1 NC_002695.1 hypothetical protein 1954913 917175 ECs1975 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310002.1 1953690 D 386585 CDS NP_310003.1 15831230 917174 1954910..1955236 1 NC_002695.1 hypothetical protein 1955236 917174 ECs1976 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310003.1 1954910 D 386585 CDS NP_310004.1 15831231 917176 1955246..1955596 1 NC_002695.1 similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 1955596 917176 ECs1977 Escherichia coli O157:H7 str. Sakai head-tail adaptor NP_310004.1 1955246 D 386585 CDS NP_310005.1 15831232 917177 1955593..1956039 1 NC_002695.1 similar to phage hypothetical proteins e.g. Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 1956039 917177 ECs1978 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310005.1 1955593 D 386585 CDS NP_310006.1 15831233 917182 1956036..1956380 1 NC_002695.1 similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 1956380 917182 ECs1979 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310006.1 1956036 D 386585 CDS NP_310007.1 15831234 917178 1956449..1957165 1 NC_002695.1 similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail protein 1957165 917178 ECs1980 Escherichia coli O157:H7 str. Sakai major tail protein NP_310007.1 1956449 D 386585 CDS NP_310008.1 15831235 917187 1957171..1957545 1 NC_002695.1 similar to tail assembly chaperon Gp14 [Bacteriophage HKJ97] gi|6901600|gb|AAF31103.1; tail assembly chaperon 1957545 917187 ECs1981 Escherichia coli O157:H7 str. Sakai tail assembly chaperon NP_310008.1 1957171 D 386585 CDS NP_310009.1 15831236 917179 1957569..1957850 1 NC_002695.1 similar to Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1; may be produced by translational frameshift; hypothetical protein 1957850 917179 ECs1982 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310009.1 1957569 D 386585 CDS NP_310010.1 15831237 917181 1957902..1960982 1 NC_002695.1 similar to tail length tape measure proteins e.g. [Bacteriophage HK97] gi|6901589|gb|AAF31092.1|AF069529_5; tail length tape measure protein 1960982 917181 ECs1983 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_310010.1 1957902 D 386585 CDS NP_310011.1 15831238 917183 1960975..1961316 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 1961316 917183 ECs1984 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310011.1 1960975 D 386585 CDS NP_310012.1 15831239 917185 1961316..1962014 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 1962014 917185 ECs1985 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310012.1 1961316 D 386585 CDS NP_310013.1 15831240 917188 1962025..1962768 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|6901605|gb|AAF31108.1; tail assembly protein 1962768 917188 ECs1986 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310013.1 1962025 D 386585 CDS NP_310014.1 15831241 917184 1962666..1963346 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 1963346 917184 ECs1987 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310014.1 1962666 D 386585 CDS NP_310015.1 15831242 917186 1963300..1963506 1 NC_002695.1 hypothetical protein 1963506 917186 ECs1988 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310015.1 1963300 D 386585 CDS NP_310016.1 15831243 917190 complement(1963537..1964064) 1 NC_002695.1 similar to copper/zinc-superoxide dismutases e.g. [Salmonella typhimurium] gi|2462699|emb|CAA73588.1; copper/zinc-superoxide dismutase 1964064 917190 ECs1989 Escherichia coli O157:H7 str. Sakai copper/zinc-superoxide dismutase NP_310016.1 1963537 R 386585 CDS NP_310017.1 15831244 917191 1964198..1967695 1 NC_002695.1 similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 1967695 917191 ECs1990 Escherichia coli O157:H7 str. Sakai host specificity protein NP_310017.1 1964198 D 386585 CDS NP_310018.1 15831245 917206 1967766..1968365 1 NC_002695.1 similar to outer membrane proteins e.g. Lom protein [Bacteriophage P-EibA] dad|AF151091-2|AAF63231.1; outer membrane protein 1968365 917206 ECs1991 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310018.1 1967766 D 386585 CDS NP_310019.1 15831246 917189 1968658..1969743 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59 (AF125520); tail fiber protein 1969743 917189 ECs1992 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_310019.1 1968658 D 386585 CDS NP_310020.1 15831247 917192 1969673..1970014 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 1970014 917192 ECs1993 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310020.1 1969673 D 386585 CDS NP_310021.1 15831248 917198 1970127..1970702 1 NC_002695.1 similar to ORF4 [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1970702 917198 ECs1994 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310021.1 1970127 D 386585 CDS NP_310022.1 15831249 917193 1970775..1971404 1 NC_002695.1 similar to ORF4 [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1971404 917193 ECs1995 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310022.1 1970775 D 386585 CDS NP_310023.1 15831250 917197 1971486..1972127 1 NC_002695.1 similar to ORF4 [Escherichia coli B171-8] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 1972127 917197 ECs1996 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310023.1 1971486 D 386585 CDS NP_310024.2 38703971 917194 complement(1972708..1973142) 1 NC_002695.1 similar to YNAF_ECOLI gi|1787640 (conserved in Escherichia coli K-12); filament protein 1973142 917194 ECs1997 Escherichia coli O157:H7 str. Sakai filament protein NP_310024.2 1972708 R 386585 CDS NP_310027.1 15831254 917200 complement(1974762..1978286) 1 NC_002695.1 similar to YDBK_ECOLI gi|1787642 (conserved in Escherichia coli K-12); oxidoreductase 1978286 917200 ECs2000 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310027.1 1974762 R 386585 CDS NP_944533.1 38703972 2693806 1978560..1978826 1 NC_002695.1 hypothetical protein 1978826 2693806 ECs5439 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944533.1 1978560 D 386585 CDS NP_310028.1 15831255 917201 complement(1978823..1979245) 1 NC_002695.1 heat shock protein; similar to HSLJ_ECOLI gi|1787644 (conserved in Escherichia coli K-12); heat-inducible protein 1979245 917201 ECs2001 Escherichia coli O157:H7 str. Sakai heat-inducible protein NP_310028.1 1978823 R 386585 CDS NP_310029.1 15831256 917202 complement(1979356..1980345) 1 NC_002695.1 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 1980345 917202 ECs2002 Escherichia coli O157:H7 str. Sakai D-lactate dehydrogenase NP_310029.1 1979356 R 386585 CDS NP_310030.1 15831257 917207 1980553..1983192 1 NC_002695.1 similar to YDBH_ECOLI gi|1787646 (conserved in Escherichia coli K-12); hypothetical protein 1983192 917207 ECs2003 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310030.1 1980553 D 386585 CDS NP_310031.1 15831258 917199 1983189..1983374 1 NC_002695.1 similar to YNBE_ECOLI gi|1787647 (conserved in Escherichia coli K-12); hypothetical protein 1983374 917199 ECs2004 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310031.1 1983189 D 386585 CDS NP_310032.1 15831259 917205 1983379..1983705 1 NC_002695.1 similar to YDBL_ECOLI gi|1787648; hypothetical protein 1983705 917205 ECs2005 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310032.1 1983379 D 386585 CDS NP_310033.1 15831260 917204 1984119..1987154 1 NC_002695.1 similar to BigA protein [Salmonella typhi] dad|AF133185-1|AAD29677.1, YdbA.2 [Escherichia coli] gi|7465766|pir||C48399; BigA-like protein 1987154 917204 ECs2006 Escherichia coli O157:H7 str. Sakai BigA-like protein NP_310033.1 1984119 D 386585 CDS NP_310034.1 15831261 917203 1987410..1989833 1 NC_002695.1 similar to BigB protein [Salmonella typhi] dad|AF133185-2|AAD29678.1, YdbA.2 [Escherichia coli] gi|7465766|pir||C48399; BigB-like protein 1989833 917203 ECs2007 Escherichia coli O157:H7 str. Sakai BigB-like protein NP_310034.1 1987410 D 386585 CDS NP_310035.1 15831262 917217 1990053..1990913 1 NC_002695.1 similar to YDBC_ECOLI gi|1787674 (conserved in Escherichia coli K-12); oxidoreductase 1990913 917217 ECs2008 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310035.1 1990053 D 386585 CDS NP_310036.1 15831263 917209 1990971..1993283 1 NC_002695.1 similar to YDBD_ECOLI gi|1787675 (conserved in Escherichia coli K-12); hypothetical protein 1993283 917209 ECs2009 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310036.1 1990971 D 386585 CDS NP_310037.2 38703973 917208 1993454..1994059 1 NC_002695.1 similar to B1408_ECOLI gi|1787676 (conserved in Escherichia coli K-12); hypothetical protein 1994059 917208 ECs2010 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310037.2 1993454 D 386585 CDS NP_310038.1 15831265 917213 1994059..1994955 1 NC_002695.1 similar to B1409_ECOLI gi|1787677 (conserved in Escherichia coli K-12); phosphatidate cytidylyltransferase 1994955 917213 ECs2011 Escherichia coli O157:H7 str. Sakai phosphatidate cytidylyltransferase NP_310038.1 1994059 D 386585 CDS NP_310039.1 15831266 917210 1994971..1996728 1 NC_002695.1 similar to B1410_ECOLI gi|1787678 (conserved in Escherichia coli K-12); hypothetical protein 1996728 917210 ECs2012 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310039.1 1994971 D 386585 CDS NP_310040.1 15831267 917211 1996742..1998034 1 NC_002695.1 similar to YNBD_ECOLI gi|1787679 (conserved in Escherichia coli K-12); hypothetical protein 1998034 917211 ECs2013 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310040.1 1996742 D 386585 CDS NP_310041.1 15831268 917215 complement(1998085..1998690) 1 NC_002695.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1998690 acpD 917215 acpD Escherichia coli O157:H7 str. Sakai azoreductase NP_310041.1 1998085 R 386585 CDS NP_310042.1 15831269 917214 1998948..2002793 1 NC_002695.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 2002793 917214 ECs2015 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase HrpA NP_310042.1 1998948 D 386585 CDS NP_310043.1 15831270 917212 2002939..2003364 1 NC_002695.1 hypothetical protein 2003364 917212 ECs2016 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310043.1 2002939 D 386585 CDS NP_310044.1 15831271 917218 2003369..2003707 1 NC_002695.1 hypothetical protein 2003707 917218 ECs2017 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310044.1 2003369 D 386585 CDS NP_310045.1 15831272 917221 2003694..2004125 1 NC_002695.1 hypothetical protein 2004125 917221 ECs2018 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310045.1 2003694 D 386585 CDS NP_310046.1 15831273 917227 2004250..2004627 1 NC_002695.1 hypothetical protein 2004627 917227 ECs2019 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310046.1 2004250 D 386585 CDS NP_310047.1 15831274 917216 2004743..2005543 1 NC_002695.1 similar to YDCF_ECOLI gi|1787683 (conserved in Escherichia coli K-12); hypothetical protein 2005543 917216 ECs2020 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310047.1 2004743 D 386585 CDS NP_310048.1 15831275 917220 2005740..2007179 1 NC_002695.1 NAD-linked; aldehyde dehydrogenase 2007179 917220 ECs2021 Escherichia coli O157:H7 str. Sakai aldehyde dehydrogenase NP_310048.1 2005740 D 386585 CDS NP_310049.1 15831276 917219 complement(2007221..2008222) 1 NC_002695.1 similar to G3P3_ECOLI sp|P33898; glyceraldehyde 3-phosphate dehydrogenase C 2008222 917219 ECs2022 Escherichia coli O157:H7 str. Sakai glyceraldehyde 3-phosphate dehydrogenase C NP_310049.1 2007221 R 386585 CDS NP_310050.2 162139795 917223 2008411..2008941 1 NC_002695.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 2008941 917223 ECs2023 Escherichia coli O157:H7 str. Sakai cytochrome b561 NP_310050.2 2008411 D 386585 CDS NP_310051.1 15831278 917225 2009186..2009359 1 NC_002695.1 similar to YDCA_ECOLI gi|1787688 (conserved in Escherichia coli K-12); hypothetical protein 2009359 917225 ECs2024 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310051.1 2009186 D 386585 CDS NP_944534.1 38703974 2693807 complement(2009431..2009580) 1 NC_002695.1 small toxic polypeptide 2009580 2693807 ECs5440 Escherichia coli O157:H7 str. Sakai small toxic polypeptide NP_944534.1 2009431 R 386585 CDS NP_310052.1 15831279 917222 complement(2009471..2009638) 1 NC_002695.1 similar to B1420_ECOLI gi|1787689 (conserved in Escherichia coli K-12); hypothetical protein 2009638 917222 ECs2025 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310052.1 2009471 R 386585 CDS NP_310053.1 15831280 917242 2009979..2011619 1 NC_002695.1 similar to TRG_ECOLI gi|1787690 (conserved in Escherichia coli K-12); methyl-accepting chemotaxis protein III 2011619 917242 ECs2026 Escherichia coli O157:H7 str. Sakai methyl-accepting chemotaxis protein III NP_310053.1 2009979 D 386585 CDS NP_310054.2 38703975 917224 complement(2011657..2012580) 1 NC_002695.1 similar to B1422_ECOLI gi|1787691 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 2012580 917224 ECs2027 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_310054.2 2011657 R 386585 CDS NP_310055.1 15831282 917226 2012797..2014140 1 NC_002695.1 similar to B1423_ECOLI gi|1787692 (conserved in Escherichia coli K-12); hypothetical protein 2014140 917226 ECs2028 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310055.1 2012797 D 386585 CDS NP_310056.1 15831283 917232 2014365..2016020 1 NC_002695.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 2016020 mdoD 917232 mdoD Escherichia coli O157:H7 str. Sakai glucan biosynthesis protein D NP_310056.1 2014365 D 386585 CDS NP_310057.1 15831284 917229 complement(2015941..2016144) 1 NC_002695.1 similar to B1425_ECOLI gi|1787694 (conserved in Escherichia coli K-12); hypothetical protein 2016144 917229 ECs2030 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310057.1 2015941 R 386585 CDS NP_310058.2 38703976 917228 2016160..2016384 1 NC_002695.1 similar to YDCH_ECOLI gi|1787696 (conserved in Escherichia coli K-12); hypothetical protein 2016384 917228 ECs2031 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310058.2 2016160 D 386585 CDS NP_310059.1 15831286 917236 2016447..2016743 1 NC_002695.1 similar to RIML_ECOLI gi|1787697; interrupted; ribosomal-protein-serine N-acetyltransferase 2016743 917236 ECs2032 Escherichia coli O157:H7 str. Sakai ribosomal-protein-serine N-acetyltransferase NP_310059.1 2016447 D 386585 CDS NP_310060.1 15831287 917230 complement(2016978..2017958) 1 NC_002695.1 similar to B1428_ECOLI gi|1787698 (conserved in Escherichia coli K-12); hypothetical protein 2017958 917230 ECs2033 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310060.1 2016978 R 386585 CDS NP_310061.1 15831288 917233 2018082..2019074 1 NC_002695.1 similar to TEHA_ECOLI gi|1787699 (conserved in Escherichia coli K-12); potassium-tellurite ethidium and proflavin transporter 2019074 917233 ECs2034 Escherichia coli O157:H7 str. Sakai potassium-tellurite ethidium and proflavin transporter NP_310061.1 2018082 D 386585 CDS NP_310062.1 15831289 917250 2019071..2019664 1 NC_002695.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 2019664 917250 ECs2035 Escherichia coli O157:H7 str. Sakai tellurite resistance protein TehB NP_310062.1 2019071 D 386585 CDS NP_310063.1 15831290 917234 2019968..2020636 1 NC_002695.1 similar to B1431_ECOLI gi|1787701 (conserved in Escherichia coli K-12); hypothetical protein 2020636 917234 ECs2036 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310063.1 2019968 D 386585 CDS NP_310064.2 38703977 917231 complement(2020671..2021843) 1 NC_002695.1 similar to membrane transport protein B1433_ECOLI gi|1787703 (conserved in Escherichia coli K-12); hypothetical protein 2021843 917231 ECs2038 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310064.2 2020671 R 386585 CDS NP_310065.1 15831292 917235 2021935..2022471 1 NC_002695.1 similar to YDCN_ECOLI gi|1787704 (conserved in Escherichia coli K-12); hypothetical protein 2022471 917235 ECs2037 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310065.1 2021935 D 386585 CDS NP_310066.1 15831293 917237 2022502..2024505 1 NC_002695.1 similar to YDCP_ECOLI gi|1787705 (conserved in Escherichia coli K-12); collagenase 2024505 917237 ECs2039 Escherichia coli O157:H7 str. Sakai collagenase NP_310066.1 2022502 D 386585 CDS NP_310067.1 15831294 917238 complement(2024597..2024827) 1 NC_002695.1 similar to B1436_ECOLI gi|1787707 (conserved in Escherichia coli K-12); hypothetical protein 2024827 917238 ECs2040 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310067.1 2024597 R 386585 CDS NP_310068.1 15831295 917239 complement(2025013..2025210) 1 NC_002695.1 similar to B1437_ECOLI gi|1787708 (conserved in Escherichia coli K-12); hypothetical protein 2025210 917239 ECs2041 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310068.1 2025013 R 386585 CDS NP_310069.1 15831296 917241 2025250..2025687 1 NC_002695.1 similar to B1438_ECOLI gi|1787709 (conserved in Escherichia coli K-12); hypothetical protein 2025687 917241 ECs2042 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310069.1 2025250 D 386585 CDS NP_310070.1 15831297 917248 2025766..2027172 1 NC_002695.1 similar to B1439_ECOLI gi|1787710 (conserved in Escherichia coli K-12); transcriptional regulator 2027172 917248 ECs2043 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_310070.1 2025766 D 386585 CDS NP_310071.1 15831298 917240 2027417..2028562 1 NC_002695.1 similar to B1440_ECOLI gi|1787711 (conserved in Escherichia coli K-12); transporter 2028562 917240 ECs2044 Escherichia coli O157:H7 str. Sakai transporter NP_310071.1 2027417 D 386585 CDS NP_310072.1 15831299 917245 2028580..2029593 1 NC_002695.1 similar to B1441_ECOLI gi|1787712 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2029593 917245 ECs2045 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310072.1 2028580 D 386585 CDS NP_310073.1 15831300 917243 2029594..2030535 1 NC_002695.1 similar to B1442_ECOLI gi|1787713 (conserved in Escherichia coli K-12); transport system permease 2030535 917243 ECs2046 Escherichia coli O157:H7 str. Sakai transport system permease NP_310073.1 2029594 D 386585 CDS NP_310074.1 15831301 917247 2030525..2031319 1 NC_002695.1 similar to B1443_ECOLI gi|1787714 (conserved in Escherichia coli K-12); transport system permease 2031319 917247 ECs2047 Escherichia coli O157:H7 str. Sakai transport system permease NP_310074.1 2030525 D 386585 CDS NP_310075.1 15831302 917246 2031341..2032765 1 NC_002695.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 2032765 917246 ECs2048 Escherichia coli O157:H7 str. Sakai gamma-aminobutyraldehyde dehydrogenase NP_310075.1 2031341 D 386585 CDS NP_310076.1 15831303 917254 2033104..2033325 1 NC_002695.1 similar to B1445_ECOLI gi|1787716 (conserved in Escherichia coli K-12); hypothetical protein 2033325 917254 ECs2049 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310076.1 2033104 D 386585 CDS NP_310077.1 15831304 917249 2033411..2033644 1 NC_002695.1 similar to B1446_ECOLI gi|1787717 (conserved in Escherichia coli K-12); hypothetical protein 2033644 917249 ECs2050 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310077.1 2033411 D 386585 CDS NP_310078.1 15831305 917256 complement(2033645..2034094) 1 NC_002695.1 similar to B1447_ECOLI gi|1787718 (conserved in Escherichia coli K-12); hypothetical protein 2034094 917256 ECs2051 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310078.1 2033645 R 386585 CDS NP_310079.1 15831306 917279 complement(2034091..2034609) 1 NC_002695.1 similar to B1448_ECOLI gi|1787719 (conserved in Escherichia coli K-12); resistance protein 2034609 917279 ECs2052 Escherichia coli O157:H7 str. Sakai resistance protein NP_310079.1 2034091 R 386585 CDS NP_310080.2 38703978 917251 2034766..2035827 1 NC_002695.1 similar to YNCB_ECOLI gi|1787721 (conserved in Escherichia coli K-12); oxidoreductase 2035827 917251 ECs2053 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310080.2 2034766 D 386585 CDS NP_310081.2 38703979 917252 2036025..2036690 1 NC_002695.1 similar to B1450_ECOLI gi|1787722 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 2036690 917252 ECs2054 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_310081.2 2036025 D 386585 CDS NP_310082.1 15831309 917253 complement(2036726..2038828) 1 NC_002695.1 similar to B1451_ECOLI gi|1787723 (conserved in Escherichia coli K-12); outer membrane receptor for iron transport 2038828 917253 ECs2055 Escherichia coli O157:H7 str. Sakai outer membrane receptor for iron transport NP_310082.1 2036726 R 386585 CDS NP_310083.1 15831310 917255 2039070..2040131 1 NC_002695.1 similar to B1452_ECOLI gi|1787724 (conserved in Escherichia coli K-12); receptor 2040131 917255 ECs2056 Escherichia coli O157:H7 str. Sakai receptor NP_310083.1 2039070 D 386585 CDS NP_310084.2 38703980 917257 complement(2040246..2041745) 1 NC_002695.1 similar to ANSP_ECOLI gi|1787725 (conserved in Escherichia coli K-12); L-asparagine permease 2041745 917257 ECs2057 Escherichia coli O157:H7 str. Sakai L-asparagine permease NP_310084.2 2040246 R 386585 CDS NP_310085.1 15831312 917259 2042012..2042629 1 NC_002695.1 similar to B1454_ECOLI gi|1787726 (conserved in Escherichia coli K-12); transferase 2042629 917259 ECs2058 Escherichia coli O157:H7 str. Sakai transferase NP_310085.1 2042012 D 386585 CDS NP_310086.1 15831313 917258 2042705..2042917 1 NC_002695.1 similar to B1455_ECOLI gi|1787727; hypothetical protein 2042917 917258 ECs2059 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310086.1 2042705 D 386585 CDS NP_310087.1 15831314 917261 2043738..2045846 1 NC_002695.1 similar to Vgr proteins e.g. VgrE protein [Escherichia coli] gi|2920625|gb|AAC32465.1; protein VgrE 2045846 917261 ECs2060 Escherichia coli O157:H7 str. Sakai protein VgrE NP_310087.1 2043738 D 386585 CDS NP_310088.1 15831315 917262 2045913..2050115 1 NC_002695.1 core protein with extension; similar to Rhs core proteins e.g. RhsD [Escherichia coli] gi|1786706 (conserved in Escherichia coli K-12); protein RhsE 2050115 917262 ECs2061 Escherichia coli O157:H7 str. Sakai protein RhsE NP_310088.1 2045913 D 386585 CDS NP_944535.1 38703981 2693808 2050312..2050521 1 NC_002695.1 hypothetical protein 2050521 2693808 ECs5441 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944535.1 2050312 D 386585 CDS NP_944536.1 38703982 2693809 2051029..2051208 1 NC_002695.1 hypothetical protein 2051208 2693809 ECs5442 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944536.1 2051029 D 386585 CDS NP_310091.1 15831318 917264 2052288..2052515 1 NC_002695.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 2052515 917264 ECs2064 Escherichia coli O157:H7 str. Sakai 4-oxalocrotonate tautomerase NP_310091.1 2052288 D 386585 CDS NP_310092.1 15831319 917265 complement(2052519..2052962) 1 NC_002695.1 similar to B1462_ECOLI gi|1787735 (conserved in Escherichia coli K-12); hypothetical protein 2052962 917265 ECs2065 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310092.1 2052519 R 386585 CDS NP_310093.1 15831320 917263 2053261..2053995 1 NC_002695.1 similar to N-hydroxyarylamine O-acetyltransferase B1463_ECOLI gi|1787736; N-hydroxyarylamine O-acetyltransferase 2053995 917263 ECs2066 Escherichia coli O157:H7 str. Sakai N-hydroxyarylamine O-acetyltransferase NP_310093.1 2053261 D 386585 CDS NP_310094.1 15831321 917267 complement(2054201..2055094) 1 NC_002695.1 similar to YDDE_ECOLI gi|1787737 (conserved in Escherichia coli K-12); hypothetical protein 2055094 917267 ECs2067 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310094.1 2054201 R 386585 CDS NP_310095.1 15831322 917268 complement(2055173..2055853) 1 NC_002695.1 similar to NARV_ECOLI gi|1787738 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit gamma 2055853 917268 ECs2068 Escherichia coli O157:H7 str. Sakai cryptic nitrate reductase 2 subunit gamma NP_310095.1 2055173 R 386585 CDS NP_310096.1 15831323 917271 complement(2055850..2056545) 1 NC_002695.1 similar to NARW_ECOLI gi|1787739 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit delta 2056545 917271 ECs2069 Escherichia coli O157:H7 str. Sakai cryptic nitrate reductase 2 subunit delta NP_310096.1 2055850 R 386585 CDS NP_310097.1 15831324 917269 complement(2056545..2058089) 1 NC_002695.1 similar to NARY_ECOLI gi|1787740 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit beta 2058089 917269 ECs2070 Escherichia coli O157:H7 str. Sakai cryptic nitrate reductase 2 subunit beta NP_310097.1 2056545 R 386585 CDS NP_310098.1 15831325 917270 complement(2058086..2061826) 1 NC_002695.1 similar to NARG_ECOLI gi|1787477 (conserved in Escherichia coli K-12); cryptic nitrate reductase 2 subunit alpha 2061826 917270 ECs2071 Escherichia coli O157:H7 str. Sakai cryptic nitrate reductase 2 subunit alpha NP_310098.1 2058086 R 386585 CDS NP_310099.1 15831326 917273 complement(2061908..2063296) 1 NC_002695.1 similar to NARU_ECOLI gi|1787743 (conserved in Escherichia coli K-12); nitrite extrusion protein 2 2063296 917273 ECs2072 Escherichia coli O157:H7 str. Sakai nitrite extrusion protein 2 NP_310099.1 2061908 R 386585 CDS NP_310100.1 15831327 917274 complement(2063602..2064861) 1 NC_002695.1 similar to B1471_ECOLI gi|1787745, B1470_ECOLI gi|1787744; hypothetical protein 2064861 917274 ECs2073 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310100.1 2063602 R 386585 CDS NP_310101.1 15831328 917272 complement(2064924..2065592) 1 NC_002695.1 similar to glycoprotein B1471_ECOLI gi|1787745; hypothetical protein 2065592 917272 ECs2074 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310101.1 2064924 R 386585 CDS NP_310102.1 15831329 917281 complement(2065679..2066182) 1 NC_002695.1 similar to IpaH protein IPA7_SHIFL gi|124813|sp|P18014, YDDK_ECOLI gi|3183258|sp|P76123; IpaH-like protein 2066182 917281 ECs2075 Escherichia coli O157:H7 str. Sakai IpaH-like protein NP_310102.1 2065679 R 386585 CDS NP_310103.1 15831330 917276 complement(2066351..2067451) 1 NC_002695.1 similar to outer membrane porin precursors e.g. NMPC_ECOLI gi|1786765; outer membrane porin protein 2067451 917276 ECs2076 Escherichia coli O157:H7 str. Sakai outer membrane porin protein NP_310103.1 2066351 R 386585 CDS NP_310104.3 162139713 917278 complement(2067710..2068591) 1 NC_002695.1 similar to YDDG_ECOLI gi|1787747 (conserved in Escherichia coli K-12); hypothetical protein 2068591 917278 ECs2077 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310104.3 2067710 R 386585 CDS NP_310105.1 15831332 917275 2068823..2071870 1 NC_002695.1 similar to FDNG_ECOLI gi|3868719 (conserved in Escherichia coli K-12); nitrate-inducible formate dehydrogenase-N alpha subunit 2071870 917275 ECs2078 Escherichia coli O157:H7 str. Sakai nitrate-inducible formate dehydrogenase-N alpha subunit NP_310105.1 2068823 D 386585 CDS NP_310106.1 15831333 917277 2071883..2072767 1 NC_002695.1 similar to FDOH_ECOLI gi|1790326 (conserved in Escherichia coli K-12); nitrate-inducible formate dehydrogenase-N iron-sulfur beta subunit 2072767 917277 ECs2079 Escherichia coli O157:H7 str. Sakai nitrate-inducible formate dehydrogenase-N iron-sulfur beta subunit NP_310106.1 2071883 D 386585 CDS NP_310107.1 15831334 917301 2072760..2073413 1 NC_002695.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 2073413 917301 ECs2080 Escherichia coli O157:H7 str. Sakai formate dehydrogenase-N subunit gamma NP_310107.1 2072760 D 386585 CDS NP_310108.2 38703985 917287 complement(2073641..2073925) 1 NC_002695.1 similar to YDDM_ECOLI gi|1787751 (conserved in Escherichia coli K-12); hypothetical protein 2073925 917287 ECs2081 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310108.2 2073641 R 386585 CDS NP_310109.2 162139794 917284 complement(2074071..2075081) 1 NC_002695.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 2075081 917284 ECs2082 Escherichia coli O157:H7 str. Sakai alcohol dehydrogenase NP_310109.2 2074071 R 386585 CDS NP_310110.2 229544782 917295 complement(2075215..2076912) 1 NC_002695.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2076912 917295 ECs2083 Escherichia coli O157:H7 str. Sakai malate dehydrogenase NP_310110.2 2075215 R 386585 CDS NP_310111.1 15831338 917282 complement(2077069..2077206) 1 NC_002695.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 2077206 rpsV 917282 rpsV Escherichia coli O157:H7 str. Sakai 30S ribosomal subunit S22 NP_310111.1 2077069 R 386585 CDS NP_310112.2 38703986 917280 complement(2077308..2077523) 1 NC_002695.1 similar to B1481_ECOLI gi|1787756 (conserved in Escherichia coli K-12); biofilm-dependent modulation protein 2077523 917280 ECs2085 Escherichia coli O157:H7 str. Sakai biofilm-dependent modulation protein NP_310112.2 2077308 R 386585 CDS NP_310113.1 15831340 917283 2077868..2078299 1 NC_002695.1 similar to OSMC_ECOLI gi|1787757 (conserved in Escherichia coli K-12); osmotically inducible protein 2078299 917283 ECs2086 Escherichia coli O157:H7 str. Sakai osmotically inducible protein NP_310113.1 2077868 D 386585 CDS NP_310114.1 15831341 917285 complement(2078355..2079281) 1 NC_002695.1 similar to B1483_ECOLI gi|1787758 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2079281 917285 ECs2087 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310114.1 2078355 R 386585 CDS NP_310115.1 15831342 917286 complement(2079274..2080260) 1 NC_002695.1 similar to B1484_ECOLI gi|1787759 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2080260 917286 ECs2088 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310115.1 2079274 R 386585 CDS NP_310116.1 15831343 917288 complement(2080257..2081153) 1 NC_002695.1 similar to B1485_ECOLI gi|1787760 (conserved in Escherichia coli K-12); ATP-dependent peptide transporter membrane subunit 2081153 917288 ECs2089 Escherichia coli O157:H7 str. Sakai ATP-dependent peptide transporter membrane subunit NP_310116.1 2080257 R 386585 CDS NP_310117.1 15831344 917289 complement(2081150..2081896) 1 NC_002695.1 similar to transport system permease B1486_ECOLI gi|1787761; hypothetical protein 2081896 917289 ECs2090 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310117.1 2081150 R 386585 CDS NP_310118.1 15831345 917292 complement(2082173..2083723) 1 NC_002695.1 similar to B1487_ECOLI gi|1787762 (conserved in Escherichia coli K-12); hemin-binding lipoprotein 2083723 917292 ECs2091 Escherichia coli O157:H7 str. Sakai hemin-binding lipoprotein NP_310118.1 2082173 R 386585 CDS NP_310119.1 15831346 917290 complement(2083737..2084318) 1 NC_002695.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 2084318 917290 ECs2092 Escherichia coli O157:H7 str. Sakai D-alanyl-D-alanine dipeptidase NP_310119.1 2083737 R 386585 CDS NP_310122.1 15831349 917293 complement(2086990..2088372) 1 NC_002695.1 similar to B1490_ECOLI gi|1787766 (conserved in Escherichia coli K-12); hypothetical protein 2088372 917293 ECs2095 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310122.1 2086990 R 386585 CDS NP_310123.1 15831350 917296 complement(2088749..2090068) 1 NC_002695.1 similar to B1491_ECOLI gi|1787767 (conserved in Escherichia coli K-12); hypothetical protein 2090068 917296 ECs2096 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310123.1 2088749 R 386585 CDS NP_310124.1 15831351 917297 complement(2090199..2091734) 1 NC_002695.1 similar to XASA_ECOLI gi|1787768 (conserved in Escherichia coli K-12); acid sensitivity protein 2091734 917297 ECs2097 Escherichia coli O157:H7 str. Sakai acid sensitivity protein NP_310124.1 2090199 R 386585 CDS NP_310125.1 15831352 917300 complement(2091890..2093290) 1 NC_002695.1 similar to GADB_ECOLI gi|1787769 (conserved in Escherichia coli K-12); glutamate decarboxylase 2093290 917300 ECs2098 Escherichia coli O157:H7 str. Sakai glutamate decarboxylase NP_310125.1 2091890 R 386585 CDS NP_310126.1 15831353 917298 complement(2093651..2096446) 1 NC_002695.1 similar to PQQL_ECOLI gi|1787770 (conserved in Escherichia coli K-12); peptidase 2096446 917298 ECs2099 Escherichia coli O157:H7 str. Sakai peptidase NP_310126.1 2093651 R 386585 CDS NP_310127.1 15831354 917306 complement(2096491..2098863) 1 NC_002695.1 similar to YDDB_ECOLI gi|1787771 (conserved in Escherichia coli K-12); hypothetical protein 2098863 917306 ECs2100 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310127.1 2096491 R 386585 CDS NP_310128.1 15831355 917299 complement(2098901..2100586) 1 NC_002695.1 similar to YDDA_ECOLI gi|1787772 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2100586 917299 ECs2101 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310128.1 2098901 R 386585 CDS NP_310129.2 38703987 917302 complement(2100877..2102034) 1 NC_002695.1 similar to B1497_ECOLI gi|1787774 (conserved in Escherichia coli K-12); hypothetical protein 2102034 917302 ECs2102 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310129.2 2100877 R 386585 CDS NP_310130.1 15831357 917303 complement(2102086..2103801) 1 NC_002695.1 similar to B1498_ECOLI gi|1787775 (conserved in Escherichia coli K-12); sulfatase 2103801 917303 ECs2103 Escherichia coli O157:H7 str. Sakai sulfatase NP_310130.1 2102086 R 386585 CDS NP_310131.1 15831358 917312 complement(2104172..2104933) 1 NC_002695.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 2104933 917312 ECs2104 Escherichia coli O157:H7 str. Sakai transcriptional regulator YdeO NP_310131.1 2104172 R 386585 CDS NP_310132.1 15831359 917320 complement(2105007..2105204) 1 NC_002695.1 similar to B1500_ECOLI gi|1787777 (conserved in Escherichia coli K-12); hypothetical protein 2105204 917320 ECs2105 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310132.1 2105007 R 386585 CDS NP_310133.1 15831360 917305 complement(2105452..2107731) 1 NC_002695.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 2107731 917305 ECs2106 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310133.1 2105452 R 386585 CDS NP_310134.1 15831361 917304 complement(2108065..2108979) 1 NC_002695.1 similar to B1502_ECOLI gi|1787779 (conserved in Escherichia coli K-12); adhesin 2108979 917304 ECs2107 Escherichia coli O157:H7 str. Sakai adhesin NP_310134.1 2108065 R 386585 CDS NP_310135.1 15831362 917314 complement(2109039..2109542) 1 NC_002695.1 similar to B1503_ECOLI gi|1787780 (conserved in Escherichia coli K-12); fimbrial-like protein 2109542 917314 ECs2108 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_310135.1 2109039 R 386585 CDS NP_310136.1 15831363 917307 complement(2109555..2110085) 1 NC_002695.1 similar to B1504_ECOLI gi|1787781 (conserved in Escherichia coli K-12); fimbrial-like protein 2110085 917307 ECs2109 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_310136.1 2109555 R 386585 CDS NP_310137.1 15831364 917309 complement(2110099..2111247) 1 NC_002695.1 similar to B1505_ECOLI gi|1787782 (conserved in Escherichia coli K-12); outer membrane protein 2111247 917309 ECs2110 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310137.1 2110099 R 386585 CDS NP_310139.1 15831366 917313 complement(2112792..2113502) 1 NC_002695.1 similar to fimbrial chaperone protein precursors e.g. FocC [Escherichia coli] gi|1169720|sp|P46008|FOCC_ECOLI; fimbrial chaperone protein 2113502 917313 ECs2112 Escherichia coli O157:H7 str. Sakai fimbrial chaperone protein NP_310139.1 2112792 R 386585 CDS NP_310140.1 15831367 917311 complement(2113863..2114426) 1 NC_002695.1 similar to type 1 fimbrial protein precursors e.g. [Escherichia coli] gi|729528|sp|P04128|FM1A_ECOLI; type 1 fimbrial protein 2114426 917311 ECs2113 Escherichia coli O157:H7 str. Sakai type 1 fimbrial protein NP_310140.1 2113863 R 386585 CDS NP_310142.1 15831369 917315 complement(2115400..2115960) 1 NC_002695.1 similar to DNA-binding regulator HIPA_ECOLI gi|1787785; hypothetical protein 2115960 917315 ECs2115 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310142.1 2115400 R 386585 CDS NP_310143.1 15831370 917317 complement(2116580..2117980) 1 NC_002695.1 similar to B1509_ECOLI gi|1787787 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2117980 917317 ECs2116 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310143.1 2116580 R 386585 CDS NP_310144.1 15831371 917316 complement(2117977..2122008) 1 NC_002695.1 similar to YDEK_ECOLI gi|1787788 (conserved in Escherichia coli K-12); lipoprotein 2122008 917316 ECs2117 Escherichia coli O157:H7 str. Sakai lipoprotein NP_310144.1 2117977 R 386585 CDS NP_310145.3 162139714 917318 complement(2122539..2124131) 1 NC_002695.1 similar to YDEV_ECOLI gi|1787789 (conserved in Escherichia coli K-12); autoinducer-2 (AI-2) kinase 2124131 917318 ECs2118 Escherichia coli O157:H7 str. Sakai autoinducer-2 (AI-2) kinase NP_310145.3 2122539 R 386585 CDS NP_310146.1 15831373 917323 complement(2124210..2125163) 1 NC_002695.1 similar to YDEW_ECOLI gi|1787791 (conserved in Escherichia coli K-12); SORC-type transcriptional regulator 2125163 917323 ECs2119 Escherichia coli O157:H7 str. Sakai SORC-type transcriptional regulator NP_310146.1 2124210 R 386585 CDS NP_310147.1 15831374 917319 2125412..2126947 1 NC_002695.1 similar to B1513_ECOLI gi|1787792 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2126947 917319 ECs2120 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310147.1 2125412 D 386585 CDS NP_310148.1 15831375 917325 2126941..2127969 1 NC_002695.1 similar to YDEY_ECOLI gi|1787793 (conserved in Escherichia coli K-12); transport system permease 2127969 917325 ECs2121 Escherichia coli O157:H7 str. Sakai transport system permease NP_310148.1 2126941 D 386585 CDS NP_310149.1 15831376 917327 2127969..2128961 1 NC_002695.1 similar to YDEZ_ECOLI gi|1787794 (conserved in Escherichia coli K-12); transport system permease 2128961 917327 ECs2122 Escherichia coli O157:H7 str. Sakai transport system permease NP_310149.1 2127969 D 386585 CDS NP_310150.1 15831377 917324 2128973..2129995 1 NC_002695.1 similar to B1516_ECOLI gi|1787795 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator 2129995 917324 ECs2123 Escherichia coli O157:H7 str. Sakai LACI-type transcriptional regulator NP_310150.1 2128973 D 386585 CDS NP_310151.1 15831378 917321 2130022..2130897 1 NC_002695.1 similar to YNEB_ECOLI gi|1787796 (conserved in Escherichia coli K-12); aldolase 2130897 917321 ECs2124 Escherichia coli O157:H7 str. Sakai aldolase NP_310151.1 2130022 D 386585 CDS NP_310152.1 15831379 917322 2130921..2131211 1 NC_002695.1 similar to B1518_ECOLI gi|1787797 (conserved in Escherichia coli K-12); autoinducer-2 (AI-2) modifying protein LsrG 2131211 917322 ECs2125 Escherichia coli O157:H7 str. Sakai autoinducer-2 (AI-2) modifying protein LsrG NP_310152.1 2130921 D 386585 CDS NP_310153.1 15831380 917326 2131268..2132026 1 NC_002695.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 2132026 917326 ECs2126 Escherichia coli O157:H7 str. Sakai trans-aconitate 2-methyltransferase NP_310153.1 2131268 D 386585 CDS NP_310154.1 15831381 917350 complement(2132030..2132995) 1 NC_002695.1 similar to B1520_ECOLI gi|1787799 (conserved in Escherichia coli K-12); hypothetical protein 2132995 917350 ECs2127 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310154.1 2132030 R 386585 CDS NP_310155.1 15831382 917329 complement(2133142..2134593) 1 NC_002695.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 2134593 917329 ECs2128 Escherichia coli O157:H7 str. Sakai altronate oxidoreductase NP_310155.1 2133142 R 386585 CDS NP_310156.1 15831383 917328 complement(2134820..2135767) 1 NC_002695.1 similar to B1522_ECOLI gi|1787802 (conserved in Escherichia coli K-12); hypothetical protein 2135767 917328 ECs2129 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310156.1 2134820 R 386585 CDS NP_310157.1 15831384 917331 complement(2136377..2136736) 1 NC_002695.1 similar to B1523_ECOLI gi|1787803 (conserved in Escherichia coli K-12); hypothetical protein 2136736 917331 ECs2130 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310157.1 2136377 R 386585 CDS NP_310158.1 15831385 917332 complement(2136736..2137662) 1 NC_002695.1 catalyzes the formation of glutamate from glutamine; glutaminase 2137662 917332 ECs2131 Escherichia coli O157:H7 str. Sakai glutaminase NP_310158.1 2136736 R 386585 CDS NP_310159.1 15831386 917330 complement(2137726..2139138) 1 NC_002695.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase 2139138 917330 ECs2132 Escherichia coli O157:H7 str. Sakai succinate semialdehyde dehydrogenase NP_310159.1 2137726 R 386585 CDS NP_310160.1 15831387 917333 2139215..2140096 1 NC_002695.1 similar to YNEJ_ECOLI gi|1787806 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 2140096 917333 ECs2133 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_310160.1 2139215 D 386585 CDS NP_310161.1 15831388 917337 2140174..2140962 1 NC_002695.1 similar to B1527_ECOLI gi|1787807; hypothetical protein 2140962 917337 ECs2134 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310161.1 2140174 D 386585 CDS NP_310162.1 15831389 917335 2141440..2142630 1 NC_002695.1 similar to YDEA_ECOLI gi|1787808 (conserved in Escherichia coli K-12); sugar efflux transporter 2142630 917335 ECs2135 Escherichia coli O157:H7 str. Sakai sugar efflux transporter NP_310162.1 2141440 D 386585 CDS NP_310163.1 15831390 917334 complement(2142655..2143320) 1 NC_002695.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 2143320 917334 ECs2136 Escherichia coli O157:H7 str. Sakai multiple drug resistance protein MarC NP_310163.1 2142655 R 386585 CDS NP_310164.2 38703989 917336 2143532..2143966 1 NC_002695.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; MarR family transcriptional regulator 2143966 917336 ECs2137 Escherichia coli O157:H7 str. Sakai MarR family transcriptional regulator NP_310164.2 2143532 D 386585 CDS NP_310165.2 162139793 917339 2143986..2144369 1 NC_002695.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; MarA family transcriptional regulator 2144369 917339 ECs2138 Escherichia coli O157:H7 str. Sakai MarA family transcriptional regulator NP_310165.2 2143986 D 386585 CDS NP_310166.1 15831393 917340 2144401..2144619 1 NC_002695.1 similar to MARB_ECOLI gi|1787812 (conserved in Escherichia coli K-12); hypothetical protein 2144619 917340 ECs2139 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310166.1 2144401 D 386585 CDS NP_310167.1 15831394 917338 complement(2144650..2145549) 1 NC_002695.1 similar to YDED_ECOLI gi|1787813 (conserved in Escherichia coli K-12); O-acetylserine/cysteine export protein 2145549 917338 ECs2140 Escherichia coli O157:H7 str. Sakai O-acetylserine/cysteine export protein NP_310167.1 2144650 R 386585 CDS NP_310168.1 15831395 917342 2145744..2146931 1 NC_002695.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 2146931 917342 ECs2141 Escherichia coli O157:H7 str. Sakai MFS-type transporter YdeE NP_310168.1 2145744 D 386585 CDS NP_944538.1 38703990 2693811 complement(2146972..2147367) 1 NC_002695.1 hypothetical protein 2147367 2693811 ECs5444 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944538.1 2146972 R 386585 CDS NP_310169.1 15831396 917345 2147064..2147348 1 NC_002695.1 hypothetical protein 2147348 917345 ECs2142 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310169.1 2147064 D 386585 CDS NP_310170.1 15831397 917341 2147459..2148433 1 NC_002695.1 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrA 2148433 ftrA 917341 ftrA Escherichia coli O157:H7 str. Sakai transcriptional activator FtrA NP_310170.1 2147459 D 386585 CDS NP_310171.1 15831398 917344 complement(2148855..2149745) 1 NC_002695.1 similar to YDEH_ECOLI gi|1787816 (conserved in Escherichia coli K-12); hypothetical protein 2149745 917344 ECs2144 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310171.1 2148855 R 386585 CDS NP_310172.1 15831399 917343 complement(2150000..2150392) 1 NC_002695.1 similar to YDEI_ECOLI gi|1787817 (conserved in Escherichia coli K-12); hypothetical protein 2150392 917343 ECs2145 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310172.1 2150000 R 386585 CDS NP_310173.1 15831400 917346 2150668..2151186 1 NC_002695.1 similar to YDEJ_ECOLI gi|1787818 (conserved in Escherichia coli K-12); competence damage-inducible protein A 2151186 917346 ECs2146 Escherichia coli O157:H7 str. Sakai competence damage-inducible protein A NP_310173.1 2150668 D 386585 CDS NP_310174.1 15831401 917348 complement(2151231..2153276) 1 NC_002695.1 similar to DCP_ECOLI gi|1787819 (conserved in Escherichia coli K-12); dipeptidyl carboxypeptidase II 2153276 917348 ECs2147 Escherichia coli O157:H7 str. Sakai dipeptidyl carboxypeptidase II NP_310174.1 2151231 R 386585 CDS NP_310175.1 15831402 917355 2153413..2154159 1 NC_002695.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 2154159 917355 ECs2148 Escherichia coli O157:H7 str. Sakai 3-hydroxy acid dehydrogenase NP_310175.1 2153413 D 386585 CDS NP_310176.1 15831403 917362 2154248..2154934 1 NC_002695.1 similar to YDFH_ECOLI gi|1787821 (conserved in Escherichia coli K-12); hypothetical protein 2154934 917362 ECs2149 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310176.1 2154248 D 386585 CDS NP_310177.1 15831404 917351 2155111..2155314 1 NC_002695.1 similar to B1541_ECOLI gi|1787822 (conserved in Escherichia coli K-12); hypothetical protein 2155314 917351 ECs2150 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310177.1 2155111 D 386585 CDS NP_310178.1 15831405 917357 complement(2155350..2156810) 1 NC_002695.1 similar to YDFI_ECOLI gi|1787823 (conserved in Escherichia coli K-12); oxidoreductase 2156810 917357 ECs2151 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310178.1 2155350 R 386585 CDS NP_310179.1 15831406 917349 complement(2156899..2158182) 1 NC_002695.1 similar to B1543_ECOLI gi|1787824 (conserved in Escherichia coli K-12); transporter 2158182 917349 ECs2152 Escherichia coli O157:H7 str. Sakai transporter NP_310179.1 2156899 R 386585 CDS NP_310180.1 15831407 917347 2158314..2158556 1 NC_002695.1 similar to damage-inducible proteins e.g. DinI [Escherichia coli] gi|2498305|sp|Q47143|DINI_ECOLI; damage-inducible protein 2158556 917347 ECs2153 Escherichia coli O157:H7 str. Sakai damage-inducible protein NP_310180.1 2158314 D 386585 CDS NP_310181.1 15831408 917352 complement(2158718..2159359) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF4 [Escherichia coli] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli] gi|4126790|dbj|BAA36748.1; hypothetical protein 2159359 917352 ECs2154 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310181.1 2158718 R 386585 CDS NP_310182.1 15831409 917353 complement(2159441..2160070) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF4 [Escherichia coli] gi|4126790|dbj|BAA36748.1, ORF2 [Escherichia coli] gi|4126792|dbj|BAA36750.1; hypothetical protein 2160070 917353 ECs2155 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310182.1 2159441 R 386585 CDS NP_310183.1 15831410 917360 complement(2160143..2160718) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF4 [Escherichia coli] gi|4126792|dbj|BAA36750.1, ORF2 [Escherichia coli] gi|4126790|dbj|BAA36748.1; hypothetical protein 2160718 917360 ECs2156 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310183.1 2160143 R 386585 CDS NP_310184.1 15831411 917354 complement(2160832..2161101) 1 NC_002695.1 similar to hypothetical protein[Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 2161101 917354 ECs2157 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310184.1 2160832 R 386585 CDS NP_310186.2 38703991 917361 complement(2161515..2162324) 1 NC_002695.1 similar to tail fiber proteins e.g. Gp37 [Escherichia coli] gi|7466858|pir||G64887, orf-401 [Bacteriophage lambda] gi|140053|sp|P03764|Y401_LAMBD; tail fiber protein 2162324 917361 ECs2159 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_310186.2 2161515 R 386585 CDS NP_310187.1 15831414 917374 complement(2162389..2162988) 1 NC_002695.1 similar to Lom-like proteins e.g.[prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2, Lom [Bacteriophage lambda] gi|138693|sp|P03701|VLOM_LAMBD; outer host membrane protein 2162988 917374 ECs2160 Escherichia coli O157:H7 str. Sakai outer host membrane protein NP_310187.1 2162389 R 386585 CDS NP_310188.1 15831415 917358 complement(2163056..2166535) 1 NC_002695.1 host specificity protein; similar to host specificity proteins e.g. GpJ [Bacteriophage lambda] gi|138412|sp|P03749|VHSJ_LAMBD; host specificity protein 2166535 917358 ECs2161 Escherichia coli O157:H7 str. Sakai host specificity protein NP_310188.1 2163056 R 386585 CDS NP_310189.1 15831416 917359 complement(2166776..2167453) 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 2167453 917359 ECs2162 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310189.1 2166776 R 386585 CDS NP_310190.1 15831417 917363 complement(2167351..2168034) 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 2168034 917363 ECs2163 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310190.1 2167351 R 386585 CDS NP_944539.1 38703992 2693798 complement(2167863..2168093) 1 NC_002695.1 hypothetical protein 2168093 2693798 ECs5445 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944539.1 2167863 R 386585 CDS NP_310191.1 15831418 917364 complement(2168104..2168802) 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 2168802 917364 ECs2164 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310191.1 2168104 R 386585 CDS NP_310192.1 15831419 917371 complement(2168802..2169131) 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 2169131 917371 ECs2165 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310192.1 2168802 R 386585 CDS NP_310193.1 15831420 917365 complement(2169128..2171740) 1 NC_002695.1 similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 2171740 917365 ECs2166 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_310193.1 2169128 R 386585 CDS NP_310194.1 15831421 917366 complement(2171721..2172134) 1 NC_002695.1 similar to minor tail proteins e.g. GpG-T [Bacteriophage lambda] gi|7429179|pir||TLBPTL; may be produced by translational frameshift; minor tail protein 2172134 917366 ECs2167 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310194.1 2171721 R 386585 CDS NP_310195.1 15831422 917370 complement(2172161..2172583) 1 NC_002695.1 similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 2172583 917370 ECs2168 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310195.1 2172161 R 386585 CDS NP_310196.1 15831423 917367 complement(2172597..2173349) 1 NC_002695.1 similar to protein V Bacteriophage lambda; hypothetical protein 2173349 917367 ECs2169 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310196.1 2172597 R 386585 CDS NP_310197.1 15831424 917369 complement(2173357..2173752) 1 NC_002695.1 similar to minor tail proteins GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein 2173752 917369 ECs2170 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310197.1 2173357 R 386585 CDS NP_310198.1 15831425 917373 complement(2173749..2174282) 1 NC_002695.1 similar to minor tail proteins e.g. GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein 2174282 917373 ECs2171 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310198.1 2173749 R 386585 CDS NP_310199.1 15831426 917368 complement(2174297..2174650) 1 NC_002695.1 minor capsid protein; similar to minor capsid proteins e.g. GpFII [Bacteriophage lambda] gi|137575|sp|P03714|VCF2_LAMBD; tail attachment protein 2174650 917368 ECs2172 Escherichia coli O157:H7 str. Sakai tail attachment protein NP_310199.1 2174297 R 386585 CDS NP_310200.1 15831427 917372 complement(2174662..2175060) 1 NC_002695.1 similar to DNA-packaging proteins e.g. GpFI [Bacteriophage lambda] gi|139324|sp|P03709|VPF1_LAMBD; DNA-packaging protein 2175060 917372 ECs2173 Escherichia coli O157:H7 str. Sakai DNA-packaging protein NP_310200.1 2174662 R 386585 CDS NP_310201.1 15831428 917378 complement(2175102..2176127) 1 NC_002695.1 similar to major capsid proteins e.g. GpE [Bacteriophage lambda] gi|116701|sp|P05481|HEAD_BPPH8; major capsid protein 2176127 917378 ECs2174 Escherichia coli O157:H7 str. Sakai major capsid protein NP_310201.1 2175102 R 386585 CDS NP_310202.1 15831429 917375 complement(2176183..2176515) 1 NC_002695.1 major capsid protein; similar to major capsid proteins e.g. GpD [Bacteriophage lambda] gi|137566|sp|P03712|VCAD_LAMBD; head decoration protein 2176515 917375 ECs2175 Escherichia coli O157:H7 str. Sakai head decoration protein NP_310202.1 2176183 R 386585 CDS NP_310203.1 15831430 917382 complement(2176525..2177844) 1 NC_002695.1 similar to minor capsid protein precursors e.g. GpC [Bacteriophage lambda] gi|137565|sp|P03711|VCAC_LAMBD; contains capsid assembly protein Nu3-homolog; minor capsid protein 2177844 917382 ECs2176 Escherichia coli O157:H7 str. Sakai minor capsid protein NP_310203.1 2176525 R 386585 CDS NP_310204.1 15831431 917381 complement(2177825..2179426) 1 NC_002695.1 minor capsid protein; similar to portal proteins e.g. GpB [Bacteriophage lambda] gi|138762|sp|P03710|VMCB_LAMBD; portal protein 2179426 917381 ECs2177 Escherichia coli O157:H7 str. Sakai portal protein NP_310204.1 2177825 R 386585 CDS NP_310205.1 15831432 917410 complement(2179423..2179629) 1 NC_002695.1 similar to head-to-tail joining proteins e.g. GpW [Bacteriophage lambda] gi|138415|sp|P03727|VHTJ_LAMBD; head-to-tail joining protein 2179629 917410 ECs2178 Escherichia coli O157:H7 str. Sakai head-to-tail joining protein NP_310205.1 2179423 R 386585 CDS NP_310206.1 15831433 917377 complement(2179626..2181551) 1 NC_002695.1 DNA-packaging protein; similar to terminase large subunits e.g. GpA [Bacteriophage lambda] gi|137616|sp|P03708|TERL_LAMBD; terminase large subunit 2181551 917377 ECs2179 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_310206.1 2179626 R 386585 CDS NP_310207.1 15831434 917376 complement(2181526..2182071) 1 NC_002695.1 similar to terminase small subunits e.g. Nu1 [Bacteriophage lambda]; terminase small subunit 2182071 917376 ECs2180 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_310207.1 2181526 R 386585 CDS NP_310208.1 15831435 917379 2182458..2182682 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein 2182682 917379 ECs2181 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310208.1 2182458 D 386585 CDS NP_310209.1 15831436 917380 complement(2182764..2183078) 1 NC_002695.1 similar to PerC (BfpW) transcriptional activator of eaeA/bfpA [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional regulator 2183078 917380 ECs2182 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_310209.1 2182764 R 386585 CDS NP_310210.1 15831437 917385 complement(2183542..2184000) 1 NC_002695.1 host cell lysis; similar to endopeptidases e.g. [Bacteriophage H-19B] gi|4335687|gb|AAD17383.1; endopeptidase 2184000 917385 ECs2184 Escherichia coli O157:H7 str. Sakai endopeptidase NP_310210.1 2183542 R 386585 CDS NP_310212.1 15831439 917384 complement(2184158..2184727) 1 NC_002695.1 similar to antirepressors e.g. [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46; antirepressor protein 2184727 917384 ECs2185 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_310212.1 2184158 R 386585 CDS NP_310213.1 15831440 917387 complement(2184998..2185531) 1 NC_002695.1 host cell lysis; similar to endolysins e.g. [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin 2185531 917387 ECs2186 Escherichia coli O157:H7 str. Sakai endolysin NP_310213.1 2184998 R 386585 CDS NP_310214.1 15831441 917391 complement(2185582..2185926) 1 NC_002695.1 similar to hypothetical protein gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 2185926 917391 ECs2187 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310214.1 2185582 R 386585 CDS NP_310215.1 15831442 917389 complement(2185931..2186137) 1 NC_002695.1 similar to holins e.g. [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1; holin 2186137 917389 ECs2188 Escherichia coli O157:H7 str. Sakai holin NP_310215.1 2185931 R 386585 CDS NP_944540.1 38703993 2693799 2186145..2186306 1 NC_002695.1 hypothetical protein 2186306 2693799 ECs5446 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944540.1 2186145 D 386585 CDS NP_310216.1 15831443 917388 complement(2186628..2188436) 1 NC_002695.1 similar to hypothetical proteins [Bacteriophage VT2-Sa] gi|5881634|dbj|BAA84325.1; hypothetical protein 2188436 917388 ECs2189 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310216.1 2186628 R 386585 CDS NP_310217.1 15831444 917393 complement(2188914..2189345) 1 NC_002695.1 similar to tellurium resistance protein TerB proteins e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein 2189345 917393 ECs2190 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310217.1 2188914 R 386585 CDS NP_310218.1 15831445 917394 complement(2189796..2190383) 1 NC_002695.1 similar to transcriptional regulators e.g. [Escherichia coli] gi|586679|sp|P37638|YHIW_ECOLI; transcriptional regulator 2190383 917394 ECs2191 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_310218.1 2189796 R 386585 CDS NP_310219.1 15831446 917395 complement(2190645..2190842) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage P27] gi|8346569|emb|CAB93762.1; hypothetical protein 2190842 917395 ECs2192 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310219.1 2190645 R 386585 CDS NP_310220.1 15831447 917398 complement(2191067..2191621) 1 NC_002695.1 similar to Q protein [Bacteriophage 21] gi|7440086|pir||D71566; anti-terminator protein 2191621 917398 ECs2193 Escherichia coli O157:H7 str. Sakai anti-terminator protein NP_310220.1 2191067 R 386585 CDS NP_310221.1 15831448 917400 complement(2191684..2191989) 1 NC_002695.1 similar crossover junction endodeoxyribonuclease [Escherichia coli] gi|2507117|sp|P40116|RUS_ECOLI, Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1; crossover junction endodeoxyribonuclease 2191989 917400 ECs2194 Escherichia coli O157:H7 str. Sakai crossover junction endodeoxyribonuclease NP_310221.1 2191684 R 386585 CDS NP_310222.1 15831449 917396 complement(2192002..2193084) 1 NC_002695.1 similar to B1560_ECOLI gi|1787843; hypothetical protein 2193084 917396 ECs2195 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310222.1 2192002 R 386585 CDS NP_310223.1 15831450 917399 complement(2193053..2193325) 1 NC_002695.1 hypothetical protein 2193325 917399 ECs2196 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310223.1 2193053 R 386585 CDS NP_310224.1 15831451 917401 complement(2193447..2193791) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585451|gb|AAD25479.1|AF125520_74, Ygi [Escherichia coli] gi|1723887|sp|P52083|YGIW_ECOLI; hypothetical protein 2193791 917401 ECs2197 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310224.1 2193447 R 386585 CDS NP_310225.1 15831452 917402 complement(2193911..2194123) 1 NC_002695.1 prophage maintenance protein; similar to MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76, Hok/Gef family e.g. Gef [Escherichia coli] gi|2120017|pir||S40540; MokW protein 2194123 917402 ECs2198 Escherichia coli O157:H7 str. Sakai MokW protein NP_310225.1 2193911 R 386585 CDS NP_310226.1 15831453 917406 complement(2194357..2194914) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585382|gb|AAD25410.1|AF125520_5; hypothetical protein 2194914 917406 ECs2199 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310226.1 2194357 R 386585 CDS NP_310227.1 15831454 917403 complement(2194916..2195134) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585384|gb|AAD25412.1|AF125520_7; hypothetical protein 2195134 917403 ECs2200 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310227.1 2194916 R 386585 CDS NP_310228.1 15831455 917411 complement(2195262..2195573) 1 NC_002695.1 hypothetical protein 2195573 917411 ECs2201 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310228.1 2195262 R 386585 CDS NP_310229.1 15831456 917404 complement(2195566..2195793) 1 NC_002695.1 hypothetical protein 2195793 917404 ECs2202 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310229.1 2195566 R 386585 CDS NP_310230.1 15831457 917407 complement(2195790..2196071) 1 NC_002695.1 similar to Gp9 [Bacteriophage Mu] gi|6010430|gb|AAF01133.1|AF083977_54; hypothetical protein 2196071 917407 ECs2203 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310230.1 2195790 R 386585 CDS NP_310231.1 15831458 917405 complement(2196104..2196838) 1 NC_002695.1 similar to hypothetical protein YdaW [Escherichia coli] gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein 2196838 917405 ECs2204 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310231.1 2196104 R 386585 CDS NP_310232.1 15831459 917429 complement(2196854..2197516) 1 NC_002695.1 similar to C-terminal half of replication protein 14 [Bacteriophage phi-80] gi|137937|sp|P14814|VG14_BPPH8; replication protein 2197516 917429 ECs2205 Escherichia coli O157:H7 str. Sakai replication protein NP_310232.1 2196854 R 386585 CDS NP_310233.1 15831460 917408 complement(2197308..2198351) 1 NC_002695.1 similar to DnaT [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein 2198351 917408 ECs2206 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310233.1 2197308 R 386585 CDS NP_310234.1 15831461 917409 complement(2198420..2198845) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|3025103|sp|P76064|YDAT_ECOLI; hypothetical protein 2198845 917409 ECs2207 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310234.1 2198420 R 386585 CDS NP_310235.1 15831462 917412 complement(2198829..2199071) 1 NC_002695.1 similar to Cro [Bacteriophage P22] gi|132195|sp|P09964|RCRO_BPP22; regulatory protein 2199071 917412 ECs2208 Escherichia coli O157:H7 str. Sakai regulatory protein NP_310235.1 2198829 R 386585 CDS NP_310236.1 15831463 917413 2199277..2199801 1 NC_002695.1 similar to repressor proteins e.g. C2 [Bacteriophage P22] gi|133359|sp|P03035|RPC2_BPP22; repressor protein 2199801 917413 ECs2209 Escherichia coli O157:H7 str. Sakai repressor protein NP_310236.1 2199277 D 386585 CDS NP_310237.1 15831464 917415 2200013..2200246 1 NC_002695.1 similar to hypothetical proteins e.g. YdfK [Escherichia coli] gi|140584|sp|P29008|YDFA_ECOLI, YdaF gi|3915965|sp|P38395|YDAF_ECOLIF; hypothetical protein 2200246 917415 ECs2210 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310237.1 2200013 D 386585 CDS NP_310238.1 15831465 917417 2200258..2200896 1 NC_002695.1 similar to ATP-dependent protease La homolog gi|1708857|sp|P42425|LON2_BACSU; hypothetical protein 2200896 917417 ECs2211 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310238.1 2200258 D 386585 CDS NP_310239.1 15831466 917414 complement(2200897..2201106) 1 NC_002695.1 hypothetical protein 2201106 917414 ECs2212 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310239.1 2200897 R 386585 CDS NP_310240.1 15831467 917416 complement(2201155..2201415) 1 NC_002695.1 hypothetical protein 2201415 917416 ECs2213 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310240.1 2201155 R 386585 CDS NP_310241.1 15831468 917423 2201671..2201859 1 NC_002695.1 similar to DicB [Escherichia coli] gi|226094|prf||1410309A; cell division inhibitor 2201859 917423 ECs2214 Escherichia coli O157:H7 str. Sakai cell division inhibitor NP_310241.1 2201671 D 386585 CDS NP_310242.1 15831469 917421 2201856..2202044 1 NC_002695.1 similar to hypothetical protein YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein 2202044 917421 ECs2215 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310242.1 2201856 D 386585 CDS NP_310243.1 15831470 917419 2202137..2203381 1 NC_002695.1 similar to exonucleases e.g. exodeoxyribonuclease VIII [Escherichia coli] gi|2507105|sp|P15032|RECE_ECOLI; exonuclease 2203381 917419 ECs2216 Escherichia coli O157:H7 str. Sakai exonuclease NP_310243.1 2202137 D 386585 CDS NP_310244.1 15831471 917420 2203363..2203914 1 NC_002695.1 similar to N-terminal part of integrases e.g. [Escherichia coli cryptic prophage] gi|7449509|pir||E64913; integrase 2203914 917420 ECs2217 Escherichia coli O157:H7 str. Sakai integrase NP_310244.1 2203363 D 386585 CDS NP_310245.1 15831472 917424 2204020..2204274 1 NC_002695.1 hypothetical protein 2204274 917424 ECs2218 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310245.1 2204020 D 386585 CDS NP_310246.1 15831473 917422 complement(2204277..2205167) 1 NC_002695.1 OrfB of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 IS629] gi|7443862|pir||T00240; transposase 2205167 917422 ECs2219 Escherichia coli O157:H7 str. Sakai transposase NP_310246.1 2204277 R 386585 CDS NP_310247.1 15831474 917426 complement(2205164..2205490) 1 NC_002695.1 OrfA of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 2205490 917426 ECs2220 Escherichia coli O157:H7 str. Sakai transposase NP_310247.1 2205164 R 386585 CDS NP_310248.1 15831475 917425 complement(2205697..2206566) 1 NC_002695.1 similar to transposases e.g. [Yersinia pestis plasmid pMT1] gi|7447905|pir||T14710; transposase 2206566 917425 ECs2221 Escherichia coli O157:H7 str. Sakai transposase NP_310248.1 2205697 R 386585 CDS NP_310249.1 15831476 917427 2206610..2206990 1 NC_002695.1 similar to L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1, hypothetical proteins e.g. Hp3 [Escherichia coli strain CFT073] gi|3661484|gb|AAC61715.1; hypothetical protein 2206990 917427 ECs2222 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310249.1 2206610 D 386585 CDS NP_310250.1 15831477 917428 2206987..2207334 1 NC_002695.1 similar to L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1, hypothetical proteins e.g. Orf50 [Escherichia coli strain B171] gi|6009426|dbj|BAA84885.1; hypothetical protein 2207334 917428 ECs2223 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310250.1 2206987 D 386585 CDS NP_310251.1 15831478 917432 2207384..2208922 1 NC_002695.1 similar to L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1, hypothetical protein [Escherichia coli plasmid pColV-K30] gi|3288156|emb|CAA11509.1; hypothetical protein 2208922 917432 ECs2224 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310251.1 2207384 D 386585 CDS NP_310253.1 15831480 917435 complement(2209505..2209876) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF2 in trcA region [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1, ORF4 in trcA region [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1; hypothetical protein 2209876 917435 ECs2226 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310253.1 2209505 R 386585 CDS NP_310254.1 15831481 917431 complement(2210140..2210487) 1 NC_002695.1 similar to hypothetical protein [Lactococcus bacteriophage c2] gi|1146281|gb|AAA92162.1|; hypothetical protein 2210487 917431 ECs2227 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310254.1 2210140 R 386585 CDS NP_310256.1 15831483 917433 complement(2210866..2211375) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF4 in trcA region [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1, ORF2 in trcA region [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1; hypothetical protein 2211375 917433 ECs2229 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310256.1 2210866 R 386585 CDS NP_310257.1 15831484 917437 complement(2211555..2211824) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|7649887|dbj|BAA94165.1; hypothetical protein 2211824 917437 ECs2230 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310257.1 2211555 R 386585 CDS NP_310258.1 15831485 917434 complement(2211826..2213049) 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 2213049 917434 ECs2231 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_310258.1 2211826 R 386585 CDS NP_310259.1 15831486 917449 complement(2213114..2213713) 1 NC_002695.1 similar to Lom outer membrane proteins e.g. [Bacteriophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein 2213713 917449 ECs2232 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310259.1 2213114 R 386585 CDS NP_310263.1 15831490 917442 complement(2217597..2218277) 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 2218277 917442 ECs2236 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310263.1 2217597 R 386585 CDS NP_310264.1 15831491 917441 complement(2218175..2218849) 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 2218849 917441 ECs2237 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310264.1 2218175 R 386585 CDS NP_310265.1 15831492 917443 complement(2218929..2219627) 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 2219627 917443 ECs2238 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310265.1 2218929 R 386585 CDS NP_310266.1 15831493 917444 complement(2219627..2219968) 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 2219968 917444 ECs2239 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310266.1 2219627 R 386585 CDS NP_310267.1 15831494 917445 complement(2219961..2223203) 1 NC_002695.1 similar to tail length tape measure proteins e.g. [Bacteriophage HK97] gi|6901589|gb|AAF31092.1|AF069529_5; tail length tape measure protein 2223203 917445 ECs2240 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_310267.1 2219961 R 386585 CDS NP_310268.1 15831495 917450 complement(2223251..2223532) 1 NC_002695.1 similar to Gp14 [Bacteriophage HK97] gi|6901601|gb|AAF31104.1; may be produced by translational frameshift; tail protein 2223532 917450 ECs2241 Escherichia coli O157:H7 str. Sakai tail protein NP_310268.1 2223251 R 386585 CDS NP_310269.1 15831496 917465 complement(2223556..2223930) 1 NC_002695.1 similar to tail assembly chaperone [Bacteriophage HK97] gi|6901600|gb|AAF31103.1; tail assembly chaperone 2223930 917465 ECs2242 Escherichia coli O157:H7 str. Sakai tail assembly chaperone NP_310269.1 2223556 R 386585 CDS NP_310270.1 15831497 917446 complement(2223945..2224661) 1 NC_002695.1 similar to major tail subunit [Bacteriophage HK97] gi|6901588|gb|AAF31091.1|AF069529_4; major tail subunit 2224661 917446 ECs2243 Escherichia coli O157:H7 str. Sakai major tail subunit NP_310270.1 2223945 R 386585 CDS NP_310271.1 15831498 917448 complement(2224727..2225071) 1 NC_002695.1 similar to Gp11 [Bacteriophage HK97] gi|6901599|gb|AAF31102.1; hypothetical protein 2225071 917448 ECs2244 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310271.1 2224727 R 386585 CDS NP_310272.1 15831499 917447 complement(2225068..2225514) 1 NC_002695.1 similar to phage hypothetical proteins Gp10 [Bacteriophage HK97] gi|6901598|gb|AAF31101.1; hypothetical protein 2225514 917447 ECs2245 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310272.1 2225068 R 386585 CDS NP_310273.1 15831500 917451 complement(2225511..2225861) 1 NC_002695.1 similar to head-tail adaptors e.g. [Bacteriophage HK97] gi|6901597|gb|AAF31100.1; head-tail adaptor 2225861 917451 ECs2246 Escherichia coli O157:H7 str. Sakai head-tail adaptor NP_310273.1 2225511 R 386585 CDS NP_310274.1 15831501 917452 complement(2225871..2226197) 1 NC_002695.1 hypothetical protein 2226197 917452 ECs2247 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310274.1 2225871 R 386585 CDS NP_310275.1 15831502 917453 complement(2226200..2228779) 1 NC_002695.1 similar to portal proteins e.g. [Bacteriophage D3] gi|5059250|gb|AAD38955.1; portal protein 2228779 917453 ECs2248 Escherichia coli O157:H7 str. Sakai portal protein NP_310275.1 2226200 R 386585 CDS NP_944541.1 38703994 2693768 complement(2228725..2228946) 1 NC_002695.1 hypothetical protein 2228946 2693768 ECs5451 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944541.1 2228725 R 386585 CDS NP_310277.1 15831504 917455 complement(2228991..2230928) 1 NC_002695.1 similar to prohead proteases e.g. [Rhodobacter capsulatus] gi|6467535|gb|AAF13181.1|AF181080_3; major head protein/prohead protease 2230928 917455 ECs2250 Escherichia coli O157:H7 str. Sakai major head protein/prohead protease NP_310277.1 2228991 R 386585 CDS NP_310278.1 15831505 917457 complement(2230992..2232653) 1 NC_002695.1 similar to hypothetical proteins e.g. phage D3 terminase-like protein [Haemophilus influenzae] gi|6739656|gb|AAF27357.1|AF198256_11; terminase large subunit 2232653 917457 ECs2251 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_310278.1 2230992 R 386585 CDS NP_310279.1 15831506 917470 complement(2232650..2233213) 1 NC_002695.1 similar to terminase small subunit - PBSX phage Bacillus subtilis gi|1722886|sp|P39785|XTMA_BACSU; terminase small subunit 2233213 917470 ECs2252 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_310279.1 2232650 R 386585 CDS NP_310280.1 15831507 917456 complement(2233397..2233540) 1 NC_002695.1 hypothetical protein 2233540 917456 ECs2253 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310280.1 2233397 R 386585 CDS NP_310281.1 15831508 917458 complement(2233503..2233868) 1 NC_002695.1 similar to DNase [Bacteriophage phi-C31] gi|1107475|emb|CAA62587.1; Dnase 2233868 917458 ECs2254 Escherichia coli O157:H7 str. Sakai Dnase NP_310281.1 2233503 R 386585 CDS NP_310282.1 15831509 917459 2233910..2234137 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|1778472|gb|AAB40755.1; hypothetical protein 2234137 917459 ECs2255 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310282.1 2233910 D 386585 CDS NP_310283.1 15831510 917462 complement(2234500..2234967) 1 NC_002695.1 cell lysis; similar to Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1, Rz endopeptidases e.g. [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 2234967 917462 ECs2257 Escherichia coli O157:H7 str. Sakai endopeptidase NP_310283.1 2234500 R 386585 CDS NP_310285.1 15831512 917461 complement(2235121..2235690) 1 NC_002695.1 similar to Ant [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor Ant [Bacteriophage P22] gi|131843|sp|P03037|RANT_BPP22; antirepressor protein 2235690 917461 ECs2258 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_310285.1 2235121 R 386585 CDS NP_310286.1 15831513 917467 complement(2235961..2236494) 1 NC_002695.1 similar to endolysins e.g. [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45; endolysin 2236494 917467 ECs2259 Escherichia coli O157:H7 str. Sakai endolysin NP_310286.1 2235961 R 386585 CDS NP_310287.1 15831514 917463 complement(2236545..2236889) 1 NC_002695.1 similar to hypothetical protein YdfR (103 aa) [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 2236889 917463 ECs2260 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310287.1 2236545 R 386585 CDS NP_310288.1 15831515 917466 complement(2236894..2237100) 1 NC_002695.1 similar to holins e.g. [Bacteriophage H-19B] gi|2668771|gb|AAD04658.1; holin 2237100 917466 ECs2261 Escherichia coli O157:H7 str. Sakai holin NP_310288.1 2236894 R 386585 CDS NP_944542.1 38703995 2693769 2237108..2237254 1 NC_002695.1 hypothetical protein 2237254 2693769 ECs5452 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944542.1 2237108 D 386585 CDS NP_310289.1 15831516 917464 complement(2237549..2239399) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W]; hypothetical protein 2239399 917464 ECs2262 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310289.1 2237549 R 386585 CDS NP_310290.1 15831517 917469 complement(2239448..2239576) 1 NC_002695.1 hypothetical protein 2239576 917469 ECs2263 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310290.1 2239448 R 386585 CDS NP_310291.1 15831518 917468 complement(2239721..2239987) 1 NC_002695.1 hypothetical protein 2239987 917468 ECs2264 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310291.1 2239721 R 386585 CDS NP_310292.1 15831519 917479 complement(2239878..2240306) 1 NC_002695.1 similar to tellurium resistance proteins (TerB) e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein 2240306 917479 ECs2265 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310292.1 2239878 R 386585 CDS NP_310294.1 15831521 917138 complement(2240946..2241635) 1 NC_002695.1 similar to antitermination Q proteins e.g. [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; antitermination protein 2241635 917138 ECs2267 Escherichia coli O157:H7 str. Sakai antitermination protein NP_310294.1 2240946 R 386585 CDS NP_310295.1 15831522 912470 complement(2241632..2241991) 1 NC_002695.1 similar to Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1, crossover junction endodeoxyribonucleases Rus; Holliday junction nuclease; crossover junction endodeoxyribonuclease 2241991 912470 ECs2268 Escherichia coli O157:H7 str. Sakai crossover junction endodeoxyribonuclease NP_310295.1 2241632 R 386585 CDS NP_310296.1 15831523 913934 complement(2242004..2243053) 1 NC_002695.1 similar to B1560_ECOLI gi|1787843; hypothetical protein 2243053 913934 ECs2269 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310296.1 2242004 R 386585 CDS NP_944589.1 38703996 2693770 complement(2243501..2243713) 1 NC_002695.1 hypothetical protein 2243713 2693770 ECs5456 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944589.1 2243501 R 386585 CDS NP_310297.1 15831524 912700 2243758..2243913 1 NC_002695.1 hypothetical protein 2243913 912700 ECs2270 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310297.1 2243758 D 386585 CDS NP_310298.1 15831525 913195 complement(2243902..2244006) 1 NC_002695.1 hypothetical protein 2244006 913195 ECs2271 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310298.1 2243902 R 386585 CDS NP_310299.1 15831526 912559 complement(2244122..2244706) 1 NC_002695.1 hypothetical protein 2244706 912559 ECs2272 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310299.1 2244122 R 386585 CDS NP_310300.1 15831527 912391 complement(2244763..2245158) 1 NC_002695.1 similar to hypothetical protein [Salmonella typhimurium] gi|7467246|pir||T03012, Ren proteins e.g. [Bacteriophage H-19] gi|2668762|gb|AAD04649.1; hypothetical protein 2245158 912391 ECs2273 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310300.1 2244763 R 386585 CDS NP_310301.1 15831528 912704 complement(2245174..2245842) 1 NC_002695.1 hypothetical protein 2245842 912704 ECs2274 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310301.1 2245174 R 386585 CDS NP_944543.1 38703997 2693771 complement(2245764..2245943) 1 NC_002695.1 hypothetical protein 2245943 2693771 ECs5457 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944543.1 2245764 R 386585 CDS NP_310302.1 15831529 913391 complement(2245969..2246709) 1 NC_002695.1 acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 2246709 913391 ECs2275 Escherichia coli O157:H7 str. Sakai replication protein NP_310302.1 2245969 R 386585 CDS NP_310303.1 15831530 913424 complement(2246716..2247627) 1 NC_002695.1 similar to replication proteins e.g. [Bacteriophage phi-80] gi|137940|sp|P14815|VG15_BPPH8, hypothetical protein [Escherichia coli] gi|3025235|sp|P75978|YMFN_ECOLI; replication protein 2247627 913424 ECs2276 Escherichia coli O157:H7 str. Sakai replication protein NP_310303.1 2246716 R 386585 CDS NP_310304.1 15831531 914073 complement(2247701..2248126) 1 NC_002695.1 similar to hypothetical protein YdaY [Escherichia coli K-12] gi|3025103|sp|P76064|YDAT_ECOLI; hypothetical protein 2248126 914073 ECs2277 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310304.1 2247701 R 386585 CDS NP_310305.1 15831532 912332 complement(2248123..2248425) 1 NC_002695.1 similar to hypothetical protein YdaS [Escherichia coli] gi|3025102|sp|P76063|YDAS_ECOLI; hypothetical protein 2248425 912332 ECs2278 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310305.1 2248123 R 386585 CDS NP_310306.1 15831533 912342 2248460..2248894 1 NC_002695.1 similar to hypothetical protein b1145 [Escherichia coli cryptic prophage e14] gi|7444154|pir||F64859; hypothetical protein 2248894 912342 ECs2279 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310306.1 2248460 D 386585 CDS NP_310307.1 15831534 914005 2248879..2249106 1 NC_002695.1 hypothetical protein 2249106 914005 ECs2280 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310307.1 2248879 D 386585 CDS NP_310308.1 15831535 913909 2249108..2249386 1 NC_002695.1 similar to hypothetical protein [Rhizobium sp. NGR234] gi|2496690|sp|P55534|Y4KP_RHISN; hypothetical protein 2249386 913909 ECs2281 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310308.1 2249108 D 386585 CDS NP_310309.1 15831536 912398 2249591..2249755 1 NC_002695.1 hypothetical protein 2249755 912398 ECs2282 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310309.1 2249591 D 386585 CDS NP_310310.1 15831537 912356 2249682..2250038 1 NC_002695.1 hypothetical protein 2250038 912356 ECs2283 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310310.1 2249682 D 386585 CDS NP_944544.1 38703998 2693772 2250110..2250328 1 NC_002695.1 hypothetical protein 2250328 2693772 ECs5458 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944544.1 2250110 D 386585 CDS NP_310311.1 15831538 914132 2250897..2251085 1 NC_002695.1 similar to DICB_ECOLI gi|1787857 (conserved in Escherichia coli K-12); inhibitor of cell division 2251085 914132 ECs2284 Escherichia coli O157:H7 str. Sakai inhibitor of cell division NP_310311.1 2250897 D 386585 CDS NP_310312.1 15831539 912445 2251082..2251273 1 NC_002695.1 similar to YDFD_ECOLI gi|1787858; hypothetical protein 2251273 912445 ECs2285 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310312.1 2251082 D 386585 CDS NP_310313.1 15831540 914232 2251366..2253837 1 NC_002695.1 similar to YDFE_ECOLI gi|1787859; hypothetical protein 2253837 914232 ECs2286 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310313.1 2251366 D 386585 CDS NP_310314.1 15831541 912393 2253910..2254161 1 NC_002695.1 similar to excisionases e.g. [Bacteriophage VT2-Sa] dad|AP000363-2|BAA84285.1; excisionase 2254161 912393 ECs2287 Escherichia coli O157:H7 str. Sakai excisionase NP_310314.1 2253910 D 386585 CDS NP_310315.1 15831542 914350 complement(2255150..2255476) 1 NC_002695.1 similar to B1582_ECOLI gi|1787865 (conserved in Escherichia coli K-12); hypothetical protein 2255476 914350 ECs2288 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310315.1 2255150 R 386585 CDS NP_310316.1 15831543 913979 2255611..2255952 1 NC_002695.1 similar to B1583_ECOLI gi|1787866 (conserved in Escherichia coli K-12); hypothetical protein 2255952 913979 ECs2289 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310316.1 2255611 D 386585 CDS NP_310317.1 15831544 915270 2255987..2256547 1 NC_002695.1 similar to SPEG_ECOLI gi|1787867 (conserved in Escherichia coli K-12); spermidine N1-acetyltransferase 2256547 915270 ECs2290 Escherichia coli O157:H7 str. Sakai spermidine N1-acetyltransferase NP_310317.1 2255987 D 386585 CDS NP_310318.2 162139792 912661 complement(2256550..2257260) 1 NC_002695.1 similar to YNFC_ECOLI gi|1787868 (conserved in Escherichia coli K-12); hypothetical protein 2257260 912661 ECs2291 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310318.2 2256550 R 386585 CDS NP_310319.1 15831546 913639 2257365..2257673 1 NC_002695.1 similar to B1586_ECOLI gi|1787869 (conserved in Escherichia coli K-12); hypothetical protein 2257673 913639 ECs2292 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310319.1 2257365 D 386585 CDS NP_310320.1 15831547 912618 2257872..2260298 1 NC_002695.1 similar to B1587_ECOLI gi|1787870 (conserved in Escherichia coli K-12); oxidoreductase major subunit 2260298 912618 ECs2293 Escherichia coli O157:H7 str. Sakai oxidoreductase major subunit NP_310320.1 2257872 D 386585 CDS NP_310321.1 15831548 912395 2260356..2262782 1 NC_002695.1 similar to B1588_ECOLI gi|1787871 (conserved in Escherichia coli K-12); oxidoreductase major subunit 2262782 912395 ECs2294 Escherichia coli O157:H7 str. Sakai oxidoreductase major subunit NP_310321.1 2260356 D 386585 CDS NP_310322.1 15831549 913903 2262793..2263410 1 NC_002695.1 similar to DMSB_ECOLI gi|1787122 (conserved in Escherichia coli K-12); oxidoreductase Fe-S subunit 2263410 913903 ECs2295 Escherichia coli O157:H7 str. Sakai oxidoreductase Fe-S subunit NP_310322.1 2262793 D 386585 CDS NP_310323.1 15831550 914008 2263412..2264266 1 NC_002695.1 similar to B1590_ECOLI gi|1787873 (conserved in Escherichia coli K-12); DMSO reductase anchor subunit 2264266 914008 ECs2296 Escherichia coli O157:H7 str. Sakai DMSO reductase anchor subunit NP_310323.1 2263412 D 386585 CDS NP_310324.2 162139791 912340 2264309..2264923 1 NC_002695.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 2264923 912340 ECs2297 Escherichia coli O157:H7 str. Sakai twin-argninine leader-binding protein DmsD NP_310324.2 2264309 D 386585 CDS NP_310325.2 162139790 916112 2265117..2266373 1 NC_002695.1 similar to B1592_ECOLI gi|1787876 (conserved in Escherichia coli K-12); voltage-gated ClC-type chloride channel ClcB 2266373 916112 ECs2298 Escherichia coli O157:H7 str. Sakai voltage-gated ClC-type chloride channel ClcB NP_310325.2 2265117 D 386585 CDS NP_310326.2 38703999 913895 complement(2266326..2267021) 1 NC_002695.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 2267021 bioD 913895 bioD Escherichia coli O157:H7 str. Sakai dithiobiotin synthetase NP_310326.2 2266326 R 386585 CDS NP_310327.1 15831554 913609 complement(2267146..2268366) 1 NC_002695.1 similar to MLC_ECOLI gi|1787878 (conserved in Escherichia coli K-12); NAGC-like transcriptional regulator 2268366 913609 ECs2300 Escherichia coli O157:H7 str. Sakai NAGC-like transcriptional regulator NP_310327.1 2267146 R 386585 CDS NP_310328.1 15831555 913369 complement(2268501..2269394) 1 NC_002695.1 similar to YNFL_ECOLI gi|1787879 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 2269394 913369 ECs2301 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_310328.1 2268501 R 386585 CDS NP_310329.1 15831556 913792 2269501..2270754 1 NC_002695.1 similar to YNFM_ECOLI gi|1787880 (conserved in Escherichia coli K-12); transporter 2270754 913792 ECs2302 Escherichia coli O157:H7 str. Sakai transporter NP_310329.1 2269501 D 386585 CDS NP_310330.2 162139789 912800 2271178..2271486 1 NC_002695.1 required for growth and survival under moderately acid conditions; acid shock protein 2271486 912800 ECs2303 Escherichia coli O157:H7 str. Sakai acid shock protein NP_310330.2 2271178 D 386585 CDS NP_310331.1 15831558 913241 2271762..2272286 1 NC_002695.1 similar to B1598_ECOLI gi|1787882 (conserved in Escherichia coli K-12); hypothetical protein 2272286 913241 ECs2304 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310331.1 2271762 D 386585 CDS NP_310332.1 15831559 912405 complement(2272621..2272950) 1 NC_002695.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 2272950 912405 ECs2305 Escherichia coli O157:H7 str. Sakai multidrug efflux system protein MdtI NP_310332.1 2272621 R 386585 CDS NP_310333.1 15831560 913399 complement(2272937..2273302) 1 NC_002695.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 2273302 913399 ECs2306 Escherichia coli O157:H7 str. Sakai multidrug efflux system protein MdtJ NP_310333.1 2272937 R 386585 CDS NP_310334.1 15831561 913758 2273714..2274748 1 NC_002695.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 2274748 tqsA 913758 tqsA Escherichia coli O157:H7 str. Sakai transporter NP_310334.1 2273714 D 386585 CDS NP_310335.1 15831562 913582 complement(2274773..2276161) 1 NC_002695.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 2276161 pntB 913582 pntB Escherichia coli O157:H7 str. Sakai pyridine nucleotide transhydrogenase NP_310335.1 2274773 R 386585 CDS NP_310336.1 15831563 913908 complement(2276172..2277704) 1 NC_002695.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 2277704 pntA 913908 pntA Escherichia coli O157:H7 str. Sakai NAD(P) transhydrogenase subunit alpha NP_310336.1 2276172 R 386585 CDS NP_310337.1 15831564 916933 2278228..2279172 1 NC_002695.1 similar to B1604_ECOLI gi|1787889 (conserved in Escherichia coli K-12); hypothetical protein 2279172 916933 ECs2310 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310337.1 2278228 D 386585 CDS NP_310338.1 15831565 916935 2279358..2280740 1 NC_002695.1 similar to B1605_ECOLI gi|1787890 (conserved in Escherichia coli K-12); arginine/ornithine antiporter 2280740 916935 ECs2311 Escherichia coli O157:H7 str. Sakai arginine/ornithine antiporter NP_310338.1 2279358 D 386585 CDS NP_310339.1 15831566 916931 2280777..2281499 1 NC_002695.1 similar to YDGB_ECOLI gi|1787891 (conserved in Escherichia coli K-12); short chain dehydrogenase 2281499 916931 ECs2312 Escherichia coli O157:H7 str. Sakai short chain dehydrogenase NP_310339.1 2280777 D 386585 CDS NP_310340.1 15831567 912634 complement(2281496..2281831) 1 NC_002695.1 similar to YDGC_ECOLI gi|1787892 (conserved in Escherichia coli K-12); hypothetical protein 2281831 912634 ECs2313 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310340.1 2281496 R 386585 CDS NP_310341.1 15831568 916930 2281951..2282679 1 NC_002695.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 2282679 916930 ECs2314 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator RstA NP_310341.1 2281951 D 386585 CDS NP_310342.1 15831569 916932 2282683..2283984 1 NC_002695.1 similar to RSTB_ECOLI gi|1787894 (conserved in Escherichia coli K-12); sensor protein RstB 2283984 916932 ECs2315 Escherichia coli O157:H7 str. Sakai sensor protein RstB NP_310342.1 2282683 D 386585 CDS NP_310343.1 15831570 916928 2284060..2284989 1 NC_002695.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 2284989 916928 ECs2316 Escherichia coli O157:H7 str. Sakai DNA replication terminus site-binding protein NP_310343.1 2284060 D 386585 CDS NP_310344.1 15831571 913708 complement(2284986..2286389) 1 NC_002695.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2286389 fumC 913708 fumC Escherichia coli O157:H7 str. Sakai fumarate hydratase NP_310344.1 2284986 R 386585 CDS NP_310345.1 15831572 916929 complement(2286532..2288178) 1 NC_002695.1 similar to FUMA_ECOLI gi|1787897 (conserved in Escherichia coli K-12); fumarase A 2288178 916929 ECs2318 Escherichia coli O157:H7 str. Sakai fumarase A NP_310345.1 2286532 R 386585 CDS NP_310346.1 15831573 916927 2288377..2289552 1 NC_002695.1 similar to MANA_ECOLI gi|1787899 (conserved in Escherichia coli K-12); mannose-6-phosphate isomerase 2289552 916927 ECs2319 Escherichia coli O157:H7 str. Sakai mannose-6-phosphate isomerase NP_310346.1 2288377 D 386585 CDS NP_310347.1 15831574 916939 2289653..2291161 1 NC_002695.1 similar to YDGA_ECOLI gi|1787900 (conserved in Escherichia coli K-12); hypothetical protein 2291161 916939 ECs2320 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310347.1 2289653 D 386585 CDS NP_310350.1 15831577 916921 complement(2292509..2293882) 1 NC_002695.1 similar to UIDB_ECOLI gi|1787902 (conserved in Escherichia coli K-12); glucuronide transporter 2293882 916921 ECs2323 Escherichia coli O157:H7 str. Sakai glucuronide transporter NP_310350.1 2292509 R 386585 CDS NP_310353.1 15831580 913631 complement(2296083..2296673) 1 NC_002695.1 similar to UIDR_ECOLI gi|1787904 (conserved in Escherichia coli K-12); repressor for uid operon 2296673 913631 ECs2326 Escherichia coli O157:H7 str. Sakai repressor for uid operon NP_310353.1 2296083 R 386585 CDS NP_310354.1 15831581 912528 complement(2296902..2297669) 1 NC_002695.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 2297669 912528 ECs2327 Escherichia coli O157:H7 str. Sakai 7-alpha-hydroxysteroid dehydrogenase NP_310354.1 2296902 R 386585 CDS NP_310355.1 15831582 914202 complement(2297781..2298809) 1 NC_002695.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 2298809 914202 ECs2328 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor MalI NP_310355.1 2297781 R 386585 CDS NP_310356.1 15831583 916922 2298984..2300576 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 2300576 916922 ECs2329 Escherichia coli O157:H7 str. Sakai bifunctional PTS system maltose and glucose-specific transporter subunits IICB NP_310356.1 2298984 D 386585 CDS NP_310357.1 15831584 916923 2300586..2301758 1 NC_002695.1 similar to MALY_ECOLI gi|1787909 (conserved in Escherichia coli K-12); aminotrasferase 2301758 916923 ECs2330 Escherichia coli O157:H7 str. Sakai aminotrasferase NP_310357.1 2300586 D 386585 CDS NP_310358.1 15831585 913624 2301862..2302863 1 NC_002695.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 2302863 913624 ECs2331 Escherichia coli O157:H7 str. Sakai adenosine deaminase NP_310358.1 2301862 D 386585 CDS NP_310359.2 38704000 914048 complement(2302899..2303939) 1 NC_002695.1 similar to B1624_ECOLI gi|1787911 (conserved in Escherichia coli K-12); oxidoreductase 2303939 914048 ECs2332 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310359.2 2302899 R 386585 CDS NP_310360.1 15831587 912438 2304182..2304307 1 NC_002695.1 similar to BLR_ECOLI gi|8953941 (conserved in Escherichia coli K-12); beta-lactam resistance protein 2304307 912438 ECs2333 Escherichia coli O157:H7 str. Sakai beta-lactam resistance protein NP_310360.1 2304182 D 386585 CDS NP_310361.1 15831588 912671 2304580..2304795 1 NC_002695.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 2304795 912671 ECs2334 Escherichia coli O157:H7 str. Sakai oriC-binding nucleoid-associated protein NP_310361.1 2304580 D 386585 CDS NP_310362.1 15831589 913795 2304857..2305321 1 NC_002695.1 similar to B1626_ECOLI gi|1787913 (conserved in Escherichia coli K-12); hypothetical protein 2305321 913795 ECs2335 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310362.1 2304857 D 386585 CDS NP_310363.1 15831590 912291 2305398..2305979 1 NC_002695.1 similar to B1627_ECOLI gi|1787914 (conserved in Escherichia coli K-12); Na(+)-translocating NADH-quinone reductase subunit E 2305979 912291 ECs2336 Escherichia coli O157:H7 str. Sakai Na(+)-translocating NADH-quinone reductase subunit E NP_310363.1 2305398 D 386585 CDS NP_310364.1 15831591 912556 2305979..2306557 1 NC_002695.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 2306557 912556 ECs2337 Escherichia coli O157:H7 str. Sakai electron transport complex protein RnfB NP_310364.1 2305979 D 386585 CDS NP_310365.1 15831592 913456 2306550..2308868 1 NC_002695.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 2308868 913456 ECs2338 Escherichia coli O157:H7 str. Sakai electron transport complex protein RnfC NP_310365.1 2306550 D 386585 CDS NP_310366.1 15831593 913023 2308869..2309927 1 NC_002695.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 2309927 rnfD 913023 rnfD Escherichia coli O157:H7 str. Sakai electron transport complex protein RnfD NP_310366.1 2308869 D 386585 CDS NP_310367.1 15831594 914445 2309931..2310551 1 NC_002695.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 2310551 914445 ECs2340 Escherichia coli O157:H7 str. Sakai electron transport complex protein RnfG NP_310367.1 2309931 D 386585 CDS NP_310368.1 15831595 913729 2310555..2311250 1 NC_002695.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 2311250 913729 ECs2341 Escherichia coli O157:H7 str. Sakai electron transport complex protein RsxE NP_310368.1 2310555 D 386585 CDS NP_310369.1 15831596 914029 2311250..2311885 1 NC_002695.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 2311885 914029 ECs2342 Escherichia coli O157:H7 str. Sakai endonuclease III NP_310369.1 2311250 D 386585 CDS NP_944545.1 38704001 2693793 2312013..2312213 1 NC_002695.1 hypothetical protein 2312213 2693793 ECs5460 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944545.1 2312013 D 386585 CDS NP_310370.1 15831597 912792 2312496..2313998 1 NC_002695.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 2313998 tppB 912792 tppB Escherichia coli O157:H7 str. Sakai tripeptide transporter permease NP_310370.1 2312496 D 386585 CDS NP_310371.1 15831598 914142 2314104..2314709 1 NC_002695.1 similar to GST_ECOLI gi|1787923 (conserved in Escherichia coli K-12); glutathionine S-transferase 2314709 914142 ECs2344 Escherichia coli O157:H7 str. Sakai glutathionine S-transferase NP_310371.1 2314104 D 386585 CDS NP_310372.1 15831599 912303 complement(2314753..2315616) 1 NC_002695.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 2315616 912303 ECs2345 Escherichia coli O157:H7 str. Sakai pyridoxamine kinase NP_310372.1 2314753 R 386585 CDS NP_310373.1 15831600 913060 complement(2315675..2316949) 1 NC_002695.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2316949 913060 ECs2346 Escherichia coli O157:H7 str. Sakai tyrosyl-tRNA synthetase NP_310373.1 2315675 R 386585 CDS NP_310374.1 15831601 912730 complement(2317078..2317734) 1 NC_002695.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2317734 912730 ECs2347 Escherichia coli O157:H7 str. Sakai pyridoxamine 5'-phosphate oxidase NP_310374.1 2317078 R 386585 CDS NP_310375.2 38704002 913759 complement(2317793..2318116) 1 NC_002695.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 2318116 913759 ECs2348 Escherichia coli O157:H7 str. Sakai lysozyme inhibitor NP_310375.2 2317793 R 386585 CDS NP_310376.1 15831603 912430 complement(2318220..2319329) 1 NC_002695.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 2319329 anmK 912430 anmK Escherichia coli O157:H7 str. Sakai anhydro-N-acetylmuramic acid kinase NP_310376.1 2318220 R 386585 CDS NP_310377.1 15831604 912692 2319602..2320069 1 NC_002695.1 similar to SLYB_ECOLI gi|1787929 (conserved in Escherichia coli K-12); outer membrane protein 2320069 912692 ECs2350 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310377.1 2319602 D 386585 CDS NP_310378.2 162139788 912735 complement(2320116..2320550) 1 NC_002695.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 2320550 912735 ECs2351 Escherichia coli O157:H7 str. Sakai transcriptional regulator SlyA NP_310378.2 2320116 R 386585 CDS NP_310379.1 15831606 912804 2320751..2320987 1 NC_002695.1 similar to B1643_ECOLI gi|1787931 (conserved in Escherichia coli K-12); hypothetical protein 2320987 912804 ECs2352 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310379.1 2320751 D 386585 CDS NP_310380.2 38704003 914262 2320990..2321847 1 NC_002695.1 similar to B1644_ECOLI gi|1787932 (conserved in Escherichia coli K-12); hypothetical protein 2321847 914262 ECs2353 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310380.2 2320990 D 386585 CDS NP_310381.1 15831608 912808 2321847..2323859 1 NC_002695.1 similar to B1645_ECOLI gi|1787933 (conserved in Escherichia coli K-12); hypothetical protein 2323859 912808 ECs2354 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310381.1 2321847 D 386585 CDS NP_310382.1 15831609 914926 complement(2323860..2324381) 1 NC_002695.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 2324381 914926 ECs2355 Escherichia coli O157:H7 str. Sakai superoxide dismutase NP_310382.1 2323860 R 386585 CDS NP_310383.1 15831610 912527 complement(2324570..2325358) 1 NC_002695.1 similar to B1647_ECOLI gi|1787936; hypothetical protein 2325358 912527 ECs2356 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310383.1 2324570 R 386585 CDS NP_310384.1 15831611 913574 complement(2325407..2325784) 1 NC_002695.1 similar to B1648_ECOLI gi|1787937 (conserved in Escherichia coli K-12); hypothetical protein 2325784 913574 ECs2358 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310384.1 2325407 R 386585 CDS NP_310385.1 15831612 912319 2325749..2326348 1 NC_002695.1 similar to B1649_ECOLI gi|1787938 (conserved in Escherichia coli K-12); hypothetical protein 2326348 912319 ECs2357 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310385.1 2325749 D 386585 CDS NP_310386.1 15831613 912715 2326385..2327482 1 NC_002695.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 2327482 912715 ECs2359 Escherichia coli O157:H7 str. Sakai N-ethylmaleimide reductase NP_310386.1 2326385 D 386585 CDS NP_310387.1 15831614 912789 2327563..2327970 1 NC_002695.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 2327970 912789 ECs2360 Escherichia coli O157:H7 str. Sakai glyoxalase I NP_310387.1 2327563 D 386585 CDS NP_310388.1 15831615 914111 2328073..2328720 1 NC_002695.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 2328720 914111 ECs2361 Escherichia coli O157:H7 str. Sakai ribonuclease T NP_310388.1 2328073 D 386585 CDS NP_310389.1 15831616 914010 2328813..2333429 1 NC_002695.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 2333429 914010 ECs2362 Escherichia coli O157:H7 str. Sakai ATP-dependent helicase Lhr NP_310389.1 2328813 D 386585 CDS NP_310390.1 15831617 912690 complement(2333480..2333827) 1 NC_002695.1 similar to YDHD_ECOLI gi|1787943 (conserved in Escherichia coli K-12); hypothetical protein 2333827 912690 ECs2363 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310390.1 2333480 R 386585 CDS NP_310391.1 15831618 912452 2334162..2334977 1 NC_002695.1 similar to YDHO_ECOLI gi|1787944 (conserved in Escherichia coli K-12); lipoprotein 2334977 912452 ECs2364 Escherichia coli O157:H7 str. Sakai lipoprotein NP_310391.1 2334162 D 386585 CDS NP_310392.1 15831619 912540 2335105..2335686 1 NC_002695.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 2335686 912540 ECs2365 Escherichia coli O157:H7 str. Sakai superoxide dismutase NP_310392.1 2335105 D 386585 CDS NP_310393.1 15831620 912314 complement(2335832..2337001) 1 NC_002695.1 similar to B1657_ECOLI gi|1787947 (conserved in Escherichia coli K-12); transporter 2337001 912314 ECs2366 Escherichia coli O157:H7 str. Sakai transporter NP_310393.1 2335832 R 386585 CDS NP_310394.1 15831621 912420 2337555..2338580 1 NC_002695.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 2338580 912420 ECs2367 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor PurR NP_310394.1 2337555 D 386585 CDS NP_310395.1 15831622 912285 complement(2338577..2339509) 1 NC_002695.1 similar to YDHB_ECOLI gi|1787949 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 2339509 912285 ECs2368 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_310395.1 2338577 R 386585 CDS NP_310396.1 15831623 914000 2339622..2340833 1 NC_002695.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 2340833 914000 ECs2369 Escherichia coli O157:H7 str. Sakai inner membrane transport protein YdhC NP_310396.1 2339622 D 386585 CDS NP_310397.1 15831624 912357 2341124..2342272 1 NC_002695.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 2342272 912357 ECs2370 Escherichia coli O157:H7 str. Sakai cyclopropane-fatty-acyl-phospholipid synthase NP_310397.1 2341124 D 386585 CDS NP_310398.1 15831625 912712 complement(2342312..2342953) 1 NC_002695.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 2342953 912712 ECs2371 Escherichia coli O157:H7 str. Sakai riboflavin synthase subunit alpha NP_310398.1 2342312 R 386585 CDS NP_310399.1 15831626 912329 2343168..2344541 1 NC_002695.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 2344541 912329 ECs2372 Escherichia coli O157:H7 str. Sakai multidrug efflux protein NP_310399.1 2343168 D 386585 CDS NP_310400.1 15831627 912283 complement(2344582..2345838) 1 NC_002695.1 similar to B1664_ECOLI gi|1787954 (conserved in Escherichia coli K-12); hypothetical protein 2345838 912283 ECs2373 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310400.1 2344582 R 386585 CDS NP_310401.1 15831628 912929 2346411..2346716 1 NC_002695.1 similar to B1667_ECOLI gi|1787956 (conserved in Escherichia coli K-12); hypothetical protein 2346716 912929 ECs2374 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310401.1 2346411 D 386585 CDS NP_310402.1 15831629 913681 2346842..2348446 1 NC_002695.1 similar to B1668_ECOLI gi|1787957 (conserved in Escherichia coli K-12); hypothetical protein 2348446 913681 ECs2375 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310402.1 2346842 D 386585 CDS NP_310403.1 15831630 913566 complement(2348458..2349270) 1 NC_002695.1 similar to B1669_ECOLI gi|1787958 (conserved in Escherichia coli K-12); hypothetical protein 2349270 913566 ECs2376 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310403.1 2348458 R 386585 CDS NP_310404.1 15831631 913750 complement(2349274..2350059) 1 NC_002695.1 similar to YDHU_ECOLI gi|1787959 (conserved in Escherichia coli K-12); hypothetical protein 2350059 913750 ECs2377 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310404.1 2349274 R 386585 CDS NP_310405.1 15831632 912453 complement(2350056..2350775) 1 NC_002695.1 similar to B1671_ECOLI gi|1787960 (conserved in Escherichia coli K-12); oxidoreductase Fe-S subunit 2350775 912453 ECs2378 Escherichia coli O157:H7 str. Sakai oxidoreductase Fe-S subunit NP_310405.1 2350056 R 386585 CDS NP_310406.1 15831633 912520 complement(2350788..2351435) 1 NC_002695.1 similar to B1672_ECOLI gi|1787961 (conserved in Escherichia coli K-12); hypothetical protein 2351435 912520 ECs2379 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310406.1 2350788 R 386585 CDS NP_310407.1 15831634 912714 complement(2351439..2353541) 1 NC_002695.1 similar to B1673_ECOLI gi|1787962 (conserved in Escherichia coli K-12); oxidoreductase 2353541 912714 ECs2380 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310407.1 2351439 R 386585 CDS NP_310408.1 15831635 914273 complement(2353562..2354188) 1 NC_002695.1 similar to B1674_ECOLI gi|1787963 (conserved in Escherichia coli K-12); hypothetical protein 2354188 914273 ECs2381 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310408.1 2353562 R 386585 CDS NP_310409.1 15831636 914156 complement(2354644..2354853) 1 NC_002695.1 similar to B1675_ECOLI gi|1787964 (conserved in Escherichia coli K-12); hypothetical protein 2354853 914156 ECs2382 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310409.1 2354644 R 386585 CDS NP_310410.1 15831637 913595 2355410..2356822 1 NC_002695.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2356822 913595 ECs2383 Escherichia coli O157:H7 str. Sakai pyruvate kinase NP_310410.1 2355410 D 386585 CDS NP_310411.1 15831638 912531 2357133..2357369 1 NC_002695.1 similar to LPP_ECOLI gi|1787967 (conserved in Escherichia coli K-12); murein lipoprotein 2357369 912531 ECs2384 Escherichia coli O157:H7 str. Sakai murein lipoprotein NP_310411.1 2357133 D 386585 CDS NP_310412.1 15831639 913220 complement(2357432..2358436) 1 NC_002695.1 similar to YNHG_ECOLI gi|1787968 (conserved in Escherichia coli K-12); hypothetical protein 2358436 913220 ECs2385 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310412.1 2357432 R 386585 CDS NP_310413.1 15831640 912512 complement(2358585..2359001) 1 NC_002695.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 2359001 912512 ECs2386 Escherichia coli O157:H7 str. Sakai cysteine desufuration protein SufE NP_310413.1 2358585 R 386585 CDS NP_310414.1 15831641 913796 complement(2359014..2360234) 1 NC_002695.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 2360234 913796 ECs2387 Escherichia coli O157:H7 str. Sakai bifunctional cysteine desulfurase/selenocysteine lyase NP_310414.1 2359014 R 386585 CDS NP_310415.1 15831642 914034 complement(2360231..2361502) 1 NC_002695.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 2361502 914034 ECs2388 Escherichia coli O157:H7 str. Sakai cysteine desulfurase activator complex subunit SufD NP_310415.1 2360231 R 386585 CDS NP_310416.1 15831643 913187 complement(2361477..2362223) 1 NC_002695.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 2362223 sufC 913187 sufC Escherichia coli O157:H7 str. Sakai cysteine desulfurase NP_310416.1 2361477 R 386585 CDS NP_310417.2 38704004 912410 complement(2362233..2363720) 1 NC_002695.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 2363720 912410 ECs2390 Escherichia coli O157:H7 str. Sakai cysteine desulfurase activator complex subunit SufB NP_310417.2 2362233 R 386585 CDS NP_310418.1 15831645 914033 complement(2363729..2364097) 1 NC_002695.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 2364097 sufA 914033 sufA Escherichia coli O157:H7 str. Sakai iron-sulfur cluster assembly scaffold protein NP_310418.1 2363729 R 386585 CDS NP_310419.1 15831646 914135 complement(2364646..2364915) 1 NC_002695.1 similar to B1685_ECOLI gi|1787975 (conserved in Escherichia coli K-12); hypothetical protein 2364915 914135 ECs2392 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310419.1 2364646 R 386585 CDS NP_310420.1 15831647 912894 complement(2364934..2365344) 1 NC_002695.1 similar to B1686_ECOLI gi|1787976 (conserved in Escherichia coli K-12); hypothetical protein 2365344 912894 ECs2393 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310420.1 2364934 R 386585 CDS NP_310421.1 15831648 912417 complement(2365341..2368397) 1 NC_002695.1 similar to YDIJ_ECOLI gi|1787977 (conserved in Escherichia coli K-12); oxidase 2368397 912417 ECs2394 Escherichia coli O157:H7 str. Sakai oxidase NP_310421.1 2365341 R 386585 CDS NP_310422.1 15831649 916554 2368786..2369898 1 NC_002695.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 2369898 916554 ECs2395 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310422.1 2368786 D 386585 CDS NP_310423.1 15831650 913865 2370300..2370683 1 NC_002695.1 similar to B1689_ECOLI gi|1787980 (conserved in Escherichia coli K-12); hypothetical protein 2370683 913865 ECs2396 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310423.1 2370300 D 386585 CDS NP_310424.1 15831651 914046 2370783..2371997 1 NC_002695.1 similar to B1690_ECOLI gi|1787981 (conserved in Escherichia coli K-12); transport system permease 2371997 914046 ECs2397 Escherichia coli O157:H7 str. Sakai transport system permease NP_310424.1 2370783 D 386585 CDS NP_310425.1 15831652 912697 2372218..2373489 1 NC_002695.1 similar to B1691_ECOLI gi|1787982 (conserved in Escherichia coli K-12); amino acid/amine transport protein 2373489 912697 ECs2398 Escherichia coli O157:H7 str. Sakai amino acid/amine transport protein NP_310425.1 2372218 D 386585 CDS NP_310426.1 15831653 912660 2373501..2374367 1 NC_002695.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 2374367 aroE 912660 aroE Escherichia coli O157:H7 str. Sakai quinate/shikimate dehydrogenase NP_310426.1 2373501 D 386585 CDS NP_310427.1 15831654 912629 2374398..2375156 1 NC_002695.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 2375156 aroD 912629 aroD Escherichia coli O157:H7 str. Sakai 3-dehydroquinate dehydratase NP_310427.1 2374398 D 386585 CDS NP_310428.1 15831655 912561 2375301..2376896 1 NC_002695.1 similar to YDIF_ECOLI gi|1787985 (conserved in Escherichia coli K-12); hypothetical protein 2376896 912561 ECs2401 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310428.1 2375301 D 386585 CDS NP_310429.2 38704005 914999 2376910..2378061 1 NC_002695.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 2378061 914999 ECs2402 Escherichia coli O157:H7 str. Sakai acyl-CoA dehydrogenase NP_310429.2 2376910 D 386585 CDS NP_310430.1 15831657 914907 complement(2378104..2379015) 1 NC_002695.1 similar to B1696_ECOLI gi|1787987 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 2379015 914907 ECs2403 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_310430.1 2378104 R 386585 CDS NP_310431.1 15831658 915310 2379331..2380095 1 NC_002695.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 2380095 915310 ECs2404 Escherichia coli O157:H7 str. Sakai electron transfer flavoprotein YdiQ NP_310431.1 2379331 D 386585 CDS NP_310432.1 15831659 917031 2380115..2381053 1 NC_002695.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 2381053 917031 ECs2405 Escherichia coli O157:H7 str. Sakai electron transfer flavoprotein subunit YdiR NP_310432.1 2380115 D 386585 CDS NP_310433.1 15831660 912361 2381109..2382398 1 NC_002695.1 similar to YDIS_ECOLI gi|1787991 (conserved in Escherichia coli K-12); hypothetical protein 2382398 912361 ECs2406 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310433.1 2381109 D 386585 CDS NP_310434.1 15831661 914182 2382395..2382688 1 NC_002695.1 similar to YDIT_ECOLI gi|1787992 (conserved in Escherichia coli K-12); hypothetical protein 2382688 914182 ECs2407 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310434.1 2382395 D 386585 CDS NP_310435.2 38704006 912954 2382745..2384391 1 NC_002695.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 2384391 912954 ECs2408 Escherichia coli O157:H7 str. Sakai short chain acyl-CoA synthetase NP_310435.2 2382745 D 386585 CDS NP_310436.1 15831663 912913 complement(2384448..2386826) 1 NC_002695.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 2386826 912913 ECs2409 Escherichia coli O157:H7 str. Sakai phosphoenolpyruvate synthase NP_310436.1 2384448 R 386585 CDS NP_310437.1 15831664 914043 2387159..2387992 1 NC_002695.1 similar to YDIA_ECOLI gi|1787995 (conserved in Escherichia coli K-12); hypothetical protein 2387992 914043 ECs2410 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310437.1 2387159 D 386585 CDS NP_310438.1 15831665 912286 2388149..2389195 1 NC_002695.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 2389195 912286 ECs2411 Escherichia coli O157:H7 str. Sakai phospho-2-dehydro-3-deoxyheptonate aldolase NP_310438.1 2388149 D 386585 CDS NP_310439.1 15831666 912284 2389327..2389518 1 NC_002695.1 similar to YDIE_ECOLI gi|1787998 (conserved in Escherichia coli K-12); hypothetical protein 2389518 912284 ECs2412 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310439.1 2389327 D 386585 CDS NP_310440.1 15831667 914103 complement(2389522..2390958) 1 NC_002695.1 similar to B1706_ECOLI gi|1787999 (conserved in Escherichia coli K-12); hypothetical protein 2390958 914103 ECs2413 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310440.1 2389522 R 386585 CDS NP_310441.1 15831668 913205 complement(2391021..2391734) 1 NC_002695.1 similar to B1707_ECOLI gi|1788000 (conserved in Escherichia coli K-12); hypothetical protein 2391734 913205 ECs2414 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310441.1 2391021 R 386585 CDS NP_310442.1 15831669 912287 complement(2391981..2392445) 1 NC_002695.1 similar to NLPC_ECOLI gi|1788001 (conserved in Escherichia coli K-12); lipoprotein 2392445 912287 ECs2415 Escherichia coli O157:H7 str. Sakai lipoprotein NP_310442.1 2391981 R 386585 CDS NP_310443.1 15831670 915033 complement(2392523..2393272) 1 NC_002695.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 2393272 915033 ECs2416 Escherichia coli O157:H7 str. Sakai vitamin B12-transporter ATPase NP_310443.1 2392523 R 386585 CDS NP_310444.1 15831671 912713 complement(2393272..2393823) 1 NC_002695.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 2393823 btuE 912713 btuE Escherichia coli O157:H7 str. Sakai glutathione peroxidase NP_310444.1 2393272 R 386585 CDS NP_310445.1 15831672 912333 complement(2393886..2394866) 1 NC_002695.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 2394866 912333 ECs2418 Escherichia coli O157:H7 str. Sakai vtamin B12-transporter permease NP_310445.1 2393886 R 386585 CDS NP_310446.1 15831673 913811 complement(2394967..2395266) 1 NC_002695.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 2395266 ihfA 913811 ihfA Escherichia coli O157:H7 str. Sakai integration host factor subunit alpha NP_310446.1 2394967 R 386585 CDS NP_310447.1 15831674 912837 complement(2395271..2397658) 1 NC_002695.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 2397658 pheT 912837 pheT Escherichia coli O157:H7 str. Sakai phenylalanyl-tRNA synthetase subunit beta NP_310447.1 2395271 R 386585 CDS NP_310448.1 15831675 916567 complement(2397673..2398656) 1 NC_002695.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2398656 pheS 916567 pheS Escherichia coli O157:H7 str. Sakai phenylalanyl-tRNA synthetase subunit alpha NP_310448.1 2397673 R 386585 CDS NP_310450.1 15831677 912729 complement(2399106..2399462) 1 NC_002695.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 2399462 rplT 912729 rplT Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L20 NP_310450.1 2399106 R 386585 CDS NP_310451.3 162139715 912347 complement(2399515..2399712) 1 NC_002695.1 similar to RPMI_ECOLI gi|1788010 (conserved in Escherichia coli K-12); 50S ribosomal protein L35 2399712 rpmI 912347 rpmI Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L35 NP_310451.3 2399515 R 386585 CDS NP_310452.1 15831679 913250 complement(2399809..2400351) 1 NC_002695.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 2400351 infC 913250 infC Escherichia coli O157:H7 str. Sakai translation initiation factor IF-3 NP_310452.1 2399809 R 386585 CDS NP_310453.1 15831680 912923 complement(2400355..2402283) 1 NC_002695.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 2402283 912923 ECs2426 Escherichia coli O157:H7 str. Sakai threonyl-tRNA synthetase NP_310453.1 2400355 R 386585 CDS NP_310454.1 15831681 912976 2402806..2404704 1 NC_002695.1 similar to B1720_ECOLI gi|1788014, 1721_ECOLI gi|1788015; hypothetical protein 2404704 912976 ECs2427 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310454.1 2402806 D 386585 CDS NP_310455.1 15831682 914231 complement(2405039..2405797) 1 NC_002695.1 similar to B1722_ECOLI gi|1788016 (conserved in Escherichia coli K-12); hypothetical protein 2405797 914231 ECs2428 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310455.1 2405039 R 386585 CDS NP_310456.2 38704008 917124 2406081..2407013 1 NC_002695.1 similar to PFKB_ECOLI gi|1788017 (conserved in Escherichia coli K-12); 6-phosphofructokinase 2407013 917124 ECs2429 Escherichia coli O157:H7 str. Sakai 6-phosphofructokinase NP_310456.2 2406081 D 386585 CDS NP_310457.1 15831684 916913 2407114..2407404 1 NC_002695.1 similar to B1724_ECOLI gi|1788018 (conserved in Escherichia coli K-12); hypothetical protein 2407404 916913 ECs2430 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310457.1 2407114 D 386585 CDS NP_310458.1 15831685 913778 2407510..2408370 1 NC_002695.1 similar to B1725_ECOLI gi|1788019 (conserved in Escherichia coli K-12); hypothetical protein 2408370 913778 ECs2431 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310458.1 2407510 D 386585 CDS NP_310459.1 15831686 915477 complement(2408411..2408947) 1 NC_002695.1 similar to B1726_ECOLI gi|1788020 (conserved in Escherichia coli K-12); hypothetical protein 2408947 915477 ECs2432 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310459.1 2408411 R 386585 CDS NP_310460.1 15831687 912766 2409094..2409762 1 NC_002695.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 2409762 912766 ECs2433 Escherichia coli O157:H7 str. Sakai 2-deoxyglucose-6-phosphatase NP_310460.1 2409094 D 386585 CDS NP_310461.2 38704009 912517 2409925..2410515 1 NC_002695.1 similar to B1728_ECOLI gi|1788023 (conserved in Escherichia coli K-12); hypothetical protein 2410515 912517 ECs2434 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310461.2 2409925 D 386585 CDS NP_310462.1 15831689 916911 2410648..2412039 1 NC_002695.1 similar to B1729_ECOLI gi|1788024 (conserved in Escherichia coli K-12); hypothetical protein 2412039 916911 ECs2435 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310462.1 2410648 D 386585 CDS NP_310463.2 38704010 917061 complement(2412090..2412857) 1 NC_002695.1 similar to B1730_ECOLI gi|1788025 (conserved in Escherichia coli K-12); hypothetical protein 2412857 917061 ECs2436 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310463.2 2412090 R 386585 CDS NP_310464.1 15831691 915364 complement(2413134..2413397) 1 NC_002695.1 similar to B1731_ECOLI gi|1788026 (conserved in Escherichia coli K-12); cell division modulator 2413397 915364 ECs2437 Escherichia coli O157:H7 str. Sakai cell division modulator NP_310464.1 2413134 R 386585 CDS NP_310465.1 15831692 916912 2413580..2415841 1 NC_002695.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 2415841 katE 916912 katE Escherichia coli O157:H7 str. Sakai hydroperoxidase II NP_310465.1 2413580 D 386585 CDS NP_310466.1 15831693 914120 complement(2415888..2416646) 1 NC_002695.1 similar to YDJC_ECOLI gi|1788028 (conserved in Escherichia coli K-12); hypothetical protein 2416646 914120 ECs2439 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310466.1 2415888 R 386585 CDS NP_310467.1 15831694 914139 complement(2416659..2418011) 1 NC_002695.1 similar to CELF_ECOLI gi|1788029 (conserved in Escherichia coli K-12); 6-phospho-beta-glucosidase 2418011 914139 ECs2440 Escherichia coli O157:H7 str. Sakai 6-phospho-beta-glucosidase NP_310467.1 2416659 R 386585 CDS NP_310468.1 15831695 913124 complement(2418117..2418959) 1 NC_002695.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 2418959 913124 ECs2441 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator ChbR NP_310468.1 2418117 R 386585 CDS NP_310469.1 15831696 916949 complement(2418967..2419317) 1 NC_002695.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 2419317 916949 ECs2442 Escherichia coli O157:H7 str. Sakai PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA NP_310469.1 2418967 R 386585 CDS NP_310470.1 15831697 916938 complement(2419368..2420726) 1 NC_002695.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 2420726 916938 ECs2443 Escherichia coli O157:H7 str. Sakai PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC NP_310470.1 2419368 R 386585 CDS NP_310471.1 15831698 912602 complement(2420811..2421131) 1 NC_002695.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 2421131 912602 ECs2444 Escherichia coli O157:H7 str. Sakai PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB NP_310471.1 2420811 R 386585 CDS NP_310472.1 15831699 912936 complement(2421431..2421769) 1 NC_002695.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; OsmE family transcriptional regulator 2421769 912936 ECs2445 Escherichia coli O157:H7 str. Sakai OsmE family transcriptional regulator NP_310472.1 2421431 R 386585 CDS NP_310473.1 15831700 916936 2421971..2422798 1 NC_002695.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2422798 nadE 916936 nadE Escherichia coli O157:H7 str. Sakai NAD synthetase NP_310473.1 2421971 D 386585 CDS NP_310474.1 15831701 912511 2423028..2423915 1 NC_002695.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 2423915 912511 ECs2447 Escherichia coli O157:H7 str. Sakai nucleotide excision repair endonuclease NP_310474.1 2423028 D 386585 CDS NP_310475.1 15831702 917112 complement(2423875..2424513) 1 NC_002695.1 similar to B1742_ECOLI gi|1788038 (conserved in Escherichia coli K-12); hypothetical protein 2424513 917112 ECs2448 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310475.1 2423875 R 386585 CDS NP_310476.1 15831703 913975 complement(2424653..2425138) 1 NC_002695.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 2425138 913975 ECs2449 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310476.1 2424653 R 386585 CDS NP_310477.1 15831704 917119 complement(2425467..2426435) 1 NC_002695.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 2426435 917119 ECs2450 Escherichia coli O157:H7 str. Sakai succinylglutamate desuccinylase NP_310477.1 2425467 R 386585 CDS NP_310478.1 15831705 914117 complement(2426428..2427771) 1 NC_002695.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 2427771 914117 ECs2451 Escherichia coli O157:H7 str. Sakai succinylarginine dihydrolase NP_310478.1 2426428 R 386585 CDS NP_310479.1 15831706 917113 complement(2427768..2429246) 1 NC_002695.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 2429246 astD 917113 astD Escherichia coli O157:H7 str. Sakai succinylglutamic semialdehyde dehydrogenase NP_310479.1 2427768 R 386585 CDS NP_310480.1 15831707 913079 complement(2429243..2430277) 1 NC_002695.1 similar to B1747_ECOLI gi|1788043 (conserved in Escherichia coli K-12); arginine succinyltransferase 2430277 913079 ECs2453 Escherichia coli O157:H7 str. Sakai arginine succinyltransferase NP_310480.1 2429243 R 386585 CDS NP_310481.1 15831708 917115 complement(2430274..2431494) 1 NC_002695.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 2431494 argD 917115 argD Escherichia coli O157:H7 str. Sakai bifunctional succinylornithine transaminase/acetylornithine transaminase NP_310481.1 2430274 R 386585 CDS NP_310482.1 15831709 912924 2431940..2432746 1 NC_002695.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 2432746 912924 ECs2455 Escherichia coli O157:H7 str. Sakai exonuclease III NP_310482.1 2431940 D 386585 CDS NP_310483.2 38704011 912631 2432913..2433623 1 NC_002695.1 similar to YDJX_ECOLI gi|1788047 (conserved in Escherichia coli K-12); hypothetical protein 2433623 912631 ECs2456 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310483.2 2432913 D 386585 CDS NP_310484.2 38704012 913554 2433628..2434305 1 NC_002695.1 similar to YDJY_ECOLI gi|1788048 (conserved in Escherichia coli K-12); hypothetical protein 2434305 913554 ECs2457 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310484.2 2433628 D 386585 CDS NP_310485.1 15831712 917012 2434320..2435027 1 NC_002695.1 similar to YDJZ_ECOLI gi|1788049 (conserved in Escherichia coli K-12); hypothetical protein 2435027 917012 ECs2458 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310485.1 2434320 D 386585 CDS NP_310486.1 15831713 916971 2435027..2435575 1 NC_002695.1 similar to YNJA_ECOLI gi|1788050 (conserved in Escherichia coli K-12); hypothetical protein 2435575 916971 ECs2459 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310486.1 2435027 D 386585 CDS NP_310487.1 15831714 914179 2435582..2436751 1 NC_002695.1 similar to B1754_ECOLI gi|1788051 (conserved in Escherichia coli K-12); ABC transporter substrate-binding protein 2436751 914179 ECs2460 Escherichia coli O157:H7 str. Sakai ABC transporter substrate-binding protein NP_310487.1 2435582 D 386585 CDS NP_310488.2 38704013 914248 2436724..2438259 1 NC_002695.1 similar to B1755_ECOLI gi|1788052 (conserved in Escherichia coli K-12); transport system permease 2438259 914248 ECs2461 Escherichia coli O157:H7 str. Sakai transport system permease NP_310488.2 2436724 D 386585 CDS NP_310489.1 15831716 916952 2438259..2438912 1 NC_002695.1 similar to B1756_ECOLI gi|1788053 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2438912 916952 ECs2462 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_310489.1 2438259 D 386585 CDS NP_310490.2 38704014 913022 2438979..2440286 1 NC_002695.1 similar to B1757_ECOLI gi|1788054 (conserved in Escherichia coli K-12); thiosulfate sulfur transferase 2440286 913022 ECs2463 Escherichia coli O157:H7 str. Sakai thiosulfate sulfur transferase NP_310490.2 2438979 D 386585 CDS NP_310491.1 15831718 912581 complement(2440295..2440921) 1 NC_002695.1 similar to B1758_ECOLI gi|1788055 (conserved in Escherichia coli K-12); cytochrome oxidase 2440921 912581 ECs2464 Escherichia coli O157:H7 str. Sakai cytochrome oxidase NP_310491.1 2440295 R 386585 CDS NP_310492.1 15831719 914002 2441002..2441409 1 NC_002695.1 similar to B1759_ECOLI gi|1788056 (conserved in Escherichia coli K-12); pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 2441409 914002 ECs2465 Escherichia coli O157:H7 str. Sakai pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase NP_310492.1 2441002 D 386585 CDS NP_310493.1 15831720 916934 complement(2441375..2441647) 1 NC_002695.1 similar to B1760_ECOLI gi|1788057 (conserved in Escherichia coli K-12); hypothetical protein 2441647 916934 ECs2466 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310493.1 2441375 R 386585 CDS NP_310494.1 15831721 917776 2441883..2443226 1 NC_002695.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 2443226 917776 ECs2467 Escherichia coli O157:H7 str. Sakai glutamate dehydrogenase NP_310494.1 2441883 D 386585 CDS NP_310495.1 15831722 917131 complement(2443343..2444383) 1 NC_002695.1 similar to B1762_ECOLI gi|1788060; hypothetical protein 2444383 917131 ECs2468 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310495.1 2443343 R 386585 CDS NP_310496.1 15831723 917132 complement(2444511..2446472) 1 NC_002695.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 2446472 917132 ECs2469 Escherichia coli O157:H7 str. Sakai DNA topoisomerase III NP_310496.1 2444511 R 386585 CDS NP_310497.1 15831724 914210 complement(2446477..2447520) 1 NC_002695.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 2447520 914210 ECs2470 Escherichia coli O157:H7 str. Sakai selenophosphate synthetase NP_310497.1 2446477 R 386585 CDS NP_310498.1 15831725 916910 complement(2447637..2448188) 1 NC_002695.1 similar to YDJA_ECOLI gi|1788063 (conserved in Escherichia coli K-12); hypothetical protein 2448188 916910 ECs2471 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310498.1 2447637 R 386585 CDS NP_310499.1 15831726 917126 2448349..2450205 1 NC_002695.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 2450205 917126 ECs2472 Escherichia coli O157:H7 str. Sakai protease 4 NP_310499.1 2448349 D 386585 CDS NP_310500.2 38704015 912674 2450309..2451031 1 NC_002695.1 similar to hypothetical proteins e.g. CJ0034c [Campylobacter jejuni] gi|6967539|emb|CAB72527.1; lipoprotein 2451031 912674 ECs2473 Escherichia coli O157:H7 str. Sakai lipoprotein NP_310500.2 2450309 D 386585 CDS NP_310501.1 15831728 916909 2451163..2452179 1 NC_002695.1 converts asparagine to aspartate and ammonia; asparaginase 2452179 ansA 916909 ansA Escherichia coli O157:H7 str. Sakai asparaginase NP_310501.1 2451163 D 386585 CDS NP_310502.2 162139787 917136 2452190..2452831 1 NC_002695.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 2452831 917136 ECs2475 Escherichia coli O157:H7 str. Sakai nicotinamidase/pyrazinamidase NP_310502.2 2452190 D 386585 CDS NP_310503.1 15831730 914154 complement(2452924..2454174) 1 NC_002695.1 similar to YDJE_ECOLI gi|1788068; transporter 2454174 914154 ECs2476 Escherichia coli O157:H7 str. Sakai transporter NP_310503.1 2452924 R 386585 CDS NP_310504.1 15831731 912346 2454237..2454563 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical proteins e.g. TnpE [Shigella flexneri] gi|5532454|gb|AAD44738.1|AF141323_9; transposase 2454563 912346 ECs2477 Escherichia coli O157:H7 str. Sakai transposase NP_310504.1 2454237 D 386585 CDS NP_310505.1 15831732 914190 2454563..2455450 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposase of IS629 gi|7443863|pir||T00315; transposase 2455450 914190 ECs2478 Escherichia coli O157:H7 str. Sakai transposase NP_310505.1 2454563 D 386585 CDS NP_310506.1 15831733 913658 complement(2455713..2456471) 1 NC_002695.1 similar to B1770_ECOLI gi|1788069 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 2456471 913658 ECs2479 Escherichia coli O157:H7 str. Sakai DeoR family transcriptional regulator NP_310506.1 2455713 R 386585 CDS NP_310507.1 15831734 913782 complement(2456608..2457588) 1 NC_002695.1 similar to B1771_ECOLI gi|1788070 (conserved in Escherichia coli K-12); hypothetical protein 2457588 913782 ECs2480 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310507.1 2456608 R 386585 CDS NP_310508.1 15831735 914258 complement(2457598..2458530) 1 NC_002695.1 similar to B1772_ECOLI gi|1788071 (conserved in Escherichia coli K-12); kinase 2458530 914258 ECs2481 Escherichia coli O157:H7 str. Sakai kinase NP_310508.1 2457598 R 386585 CDS NP_310509.1 15831736 912677 complement(2458535..2459371) 1 NC_002695.1 similar to B1773_ECOLI gi|1788072 (conserved in Escherichia coli K-12); aldolase 2459371 912677 ECs2482 Escherichia coli O157:H7 str. Sakai aldolase NP_310509.1 2458535 R 386585 CDS NP_310510.1 15831737 912814 complement(2459392..2460435) 1 NC_002695.1 similar to YDJJ_ECOLI gi|1788073 (conserved in Escherichia coli K-12); oxidoreductase 2460435 912814 ECs2483 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310510.1 2459392 R 386585 CDS NP_310511.1 15831738 913715 complement(2460452..2461831) 1 NC_002695.1 similar to B1775_ECOLI gi|1788074 (conserved in Escherichia coli K-12); transporter 2461831 913715 ECs2484 Escherichia coli O157:H7 str. Sakai transporter NP_310511.1 2460452 R 386585 CDS NP_310512.1 15831739 913710 complement(2461858..2462934) 1 NC_002695.1 similar to B1776_ECOLI gi|1788075 (conserved in Escherichia coli K-12); oxidoreductase 2462934 913710 ECs2485 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_310512.1 2461858 R 386585 CDS NP_310513.2 38704016 912822 complement(2463304..2463576) 1 NC_002695.1 similar to B1777_ECOLI gi|1788076 (conserved in Escherichia coli K-12); hypothetical protein 2463576 912822 ECs2486 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310513.2 2463304 R 386585 CDS NP_310514.1 15831741 912866 complement(2463618..2464031) 1 NC_002695.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 2464031 912866 ECs2487 Escherichia coli O157:H7 str. Sakai methionine sulfoxide reductase B NP_310514.1 2463618 R 386585 CDS NP_310515.1 15831742 913285 2464373..2465368 1 NC_002695.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 2465368 913285 ECs2488 Escherichia coli O157:H7 str. Sakai glyceraldehyde-3-phosphate dehydrogenase NP_310515.1 2464373 D 386585 CDS NP_310516.2 38704017 915156 2465452..2466336 1 NC_002695.1 similar to YEAD_ECOLI gi|1788080 (conserved in Escherichia coli K-12); hypothetical protein 2466336 915156 ECs2489 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310516.2 2465452 D 386585 CDS NP_310517.1 15831744 912745 complement(2466387..2467241) 1 NC_002695.1 similar to B1781_ECOLI gi|1788081 (conserved in Escherichia coli K-12); aldehyde reductase 2467241 912745 ECs2490 Escherichia coli O157:H7 str. Sakai aldehyde reductase NP_310517.1 2466387 R 386585 CDS NP_310518.1 15831745 912705 complement(2467331..2468077) 1 NC_002695.1 similar to MIPA_ECOLI gi|1788082 (conserved in Escherichia coli K-12); scaffolding protein in the formation of a murein-synthesizing holoenzyme 2468077 912705 ECs2491 Escherichia coli O157:H7 str. Sakai scaffolding protein in the formation of a murein-synthesizing holoenzyme NP_310518.1 2467331 R 386585 CDS NP_310519.1 15831746 913722 2468513..2470447 1 NC_002695.1 similar to YEAG_ECOLI gi|1788083 (conserved in Escherichia coli K-12); hypothetical protein 2470447 913722 ECs2492 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310519.1 2468513 D 386585 CDS NP_310520.1 15831747 912737 2470560..2471843 1 NC_002695.1 similar to YEAH_ECOLI gi|1788084 (conserved in Escherichia coli K-12); hypothetical protein 2471843 912737 ECs2493 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310520.1 2470560 D 386585 CDS NP_310521.1 15831748 912853 2472122..2473465 1 NC_002695.1 similar to YEAI_ECOLI gi|1788085 (conserved in Escherichia coli K-12); hypothetical protein 2473465 912853 ECs2494 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310521.1 2472122 D 386585 CDS NP_310522.2 162139786 912760 2473646..2475136 1 NC_002695.1 similar to YEAJ_ECOLI gi|1788086 (conserved in Escherichia coli K-12); hypothetical protein 2475136 912760 ECs2495 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310522.2 2473646 D 386585 CDS NP_310523.1 15831750 912573 2475179..2475682 1 NC_002695.1 similar to YEAK_ECOLI gi|1788087 (conserved in Escherichia coli K-12); hypothetical protein 2475682 912573 ECs2496 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310523.1 2475179 D 386585 CDS NP_310524.1 15831751 912755 complement(2475683..2475835) 1 NC_002695.1 similar to B1788_ECOLI gi|1788088 (conserved in Escherichia coli K-12); hypothetical protein 2475835 912755 ECs2497 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310524.1 2475683 R 386585 CDS NP_310525.1 15831752 913210 2475957..2476403 1 NC_002695.1 similar to YEAL_ECOLI gi|1788090 (conserved in Escherichia coli K-12); hypothetical protein 2476403 913210 ECs2498 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310525.1 2475957 D 386585 CDS NP_310526.1 15831753 913951 complement(2476360..2477181) 1 NC_002695.1 similar to YEAM_ECOLI gi|1788091 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 2477181 913951 ECs2499 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_310526.1 2476360 R 386585 CDS NP_310527.1 15831754 913931 2477278..2478459 1 NC_002695.1 similar to YEAN_ECOLI gi|1788092 (conserved in Escherichia coli K-12); amino acid/amine transport protein 2478459 913931 ECs2500 Escherichia coli O157:H7 str. Sakai amino acid/amine transport protein NP_310527.1 2477278 D 386585 CDS NP_310528.2 229544781 913675 2478514..2478861 1 NC_002695.1 similar to YEAO_ECOLI gi|1788093 (conserved in Escherichia coli K-12); hypothetical protein 2478861 913675 ECs2501 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310528.2 2478514 D 386585 CDS NP_310529.1 15831756 913358 complement(2478883..2479137) 1 NC_002695.1 similar to YOAF_ECOLI gi|1788094 (conserved in Escherichia coli K-12); hypothetical protein 2479137 913358 ECs2502 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310529.1 2478883 R 386585 CDS NP_310530.1 15831757 913888 2479320..2480168 1 NC_002695.1 similar to YAEP_ECOLI gi|1788095 (conserved in Escherichia coli K-12); hypothetical protein 2480168 913888 ECs2503 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310530.1 2479320 D 386585 CDS NP_310531.1 15831758 913024 complement(2480612..2480860) 1 NC_002695.1 similar to YEAQ_ECOLI gi|1788096 (conserved in Escherichia coli K-12); hypothetical protein 2480860 913024 ECs2504 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310531.1 2480612 R 386585 CDS NP_310532.1 15831759 916565 complement(2481007..2481189) 1 NC_002695.1 similar to YOAG_ECOLI gi|1788097 (conserved in Escherichia coli K-12); hypothetical protein 2481189 916565 ECs2505 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310532.1 2481007 R 386585 CDS NP_310533.1 15831760 914119 complement(2481193..2481552) 1 NC_002695.1 similar to YEAR_ECOLI gi|1788098 (conserved in Escherichia coli K-12); hypothetical protein 2481552 914119 ECs2506 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310533.1 2481193 R 386585 CDS NP_310534.1 15831761 912651 complement(2481725..2482363) 1 NC_002695.1 similar to YEAS_ECOLI gi|1788099 (conserved in Escherichia coli K-12); leucine export protein LeuE 2482363 912651 ECs2507 Escherichia coli O157:H7 str. Sakai leucine export protein LeuE NP_310534.1 2481725 R 386585 CDS NP_310535.2 38704018 913737 complement(2482490..2483413) 1 NC_002695.1 similar to YEAT_ECOLI gi|1788100 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 2483413 913737 ECs2508 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_310535.2 2482490 R 386585 CDS NP_310536.1 15831763 914239 2483516..2484601 1 NC_002695.1 similar to YEAU_ECOLI gi|1788101 (conserved in Escherichia coli K-12); tartrate dehydrogenase 2484601 914239 ECs2509 Escherichia coli O157:H7 str. Sakai tartrate dehydrogenase NP_310536.1 2483516 D 386585 CDS NP_310537.1 15831764 912973 2485017..2486462 1 NC_002695.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 2486462 912973 ECs2510 Escherichia coli O157:H7 str. Sakai transporter NP_310537.1 2485017 D 386585 CDS NP_310538.1 15831765 912476 2486494..2487618 1 NC_002695.1 similar to YEAW_ECOLI gi|1788103 (conserved in Escherichia coli K-12); hypothetical protein 2487618 912476 ECs2511 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310538.1 2486494 D 386585 CDS NP_310539.1 15831766 912664 2487674..2488639 1 NC_002695.1 similar to YEAX_ECOLI gi|1788104 (conserved in Escherichia coli K-12); diogenase subunit beta 2488639 912664 ECs2512 Escherichia coli O157:H7 str. Sakai diogenase subunit beta NP_310539.1 2487674 D 386585 CDS NP_310540.1 15831767 913837 complement(2488693..2489820) 1 NC_002695.1 similar to RND_ECOLI gi|1788105 (conserved in Escherichia coli K-12); ribonuclease D 2489820 913837 ECs2513 Escherichia coli O157:H7 str. Sakai ribonuclease D NP_310540.1 2488693 R 386585 CDS NP_310541.1 15831768 912449 complement(2489890..2491575) 1 NC_002695.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 2491575 912449 ECs2514 Escherichia coli O157:H7 str. Sakai long-chain-fatty-acid--CoA ligase NP_310541.1 2489890 R 386585 CDS NP_310542.1 15831769 912846 complement(2491780..2492361) 1 NC_002695.1 similar to B1806_ECOLI gi|1788108 (conserved in Escherichia coli K-12); outer membrane protein 2492361 912846 ECs2515 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310542.1 2491780 R 386585 CDS NP_310543.1 15831770 915193 complement(2492401..2493096) 1 NC_002695.1 similar to YEAZ_ECOLI gi|1788109 (conserved in Escherichia coli K-12); hypothetical protein 2493096 915193 ECs2516 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310543.1 2492401 R 386585 CDS NP_310544.1 15831771 912798 complement(2493154..2495064) 1 NC_002695.1 similar to B1808_ECOLI gi|1788110 (conserved in Escherichia coli K-12); hypothetical protein 2495064 912798 ECs2517 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310544.1 2493154 R 386585 CDS NP_310545.1 15831772 912885 2495148..2495540 1 NC_002695.1 similar to B1809_ECOLI gi|1788111 (conserved in Escherichia coli K-12); hypothetical protein 2495540 912885 ECs2518 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310545.1 2495148 D 386585 CDS NP_310546.1 15831773 912709 2495902..2496261 1 NC_002695.1 similar to B1810_ECOLI gi|1788112 (conserved in Escherichia coli K-12); hypothetical protein 2496261 912709 ECs2519 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310546.1 2495902 D 386585 CDS NP_310547.1 15831774 912673 complement(2496381..2496560) 1 NC_002695.1 similar to B1811_ECOLI gi|1788113 (conserved in Escherichia coli K-12); hypothetical protein 2496560 912673 ECs2520 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310547.1 2496381 R 386585 CDS NP_310548.1 15831775 914166 2496634..2497995 1 NC_002695.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 2497995 914166 ECs2521 Escherichia coli O157:H7 str. Sakai para-aminobenzoate synthase component I NP_310548.1 2496634 D 386585 CDS NP_310549.1 15831776 912636 2497999..2498577 1 NC_002695.1 similar to YEAB_ECOLI gi|1788115 (conserved in Escherichia coli K-12); hypothetical protein 2498577 912636 ECs2522 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310549.1 2497999 D 386585 CDS NP_310550.1 15831777 912552 2498761..2500125 1 NC_002695.1 similar to SDAA_ECOLI gi|1788116 (conserved in Escherichia coli K-12); L-serine dehydratase 1 2500125 912552 ECs2523 Escherichia coli O157:H7 str. Sakai L-serine dehydratase 1 NP_310550.1 2498761 D 386585 CDS NP_310551.1 15831778 912289 2500226..2501854 1 NC_002695.1 similar to B1815_ECOLI gi|1788118 (conserved in Escherichia coli K-12); hypothetical protein 2501854 912289 ECs2524 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310551.1 2500226 D 386585 CDS NP_310552.1 15831779 914066 complement(2501858..2503414) 1 NC_002695.1 similar to YOAE_ECOLI gi|1788119 (conserved in Escherichia coli K-12); transporter 2503414 914066 ECs2525 Escherichia coli O157:H7 str. Sakai transporter NP_310552.1 2501858 R 386585 CDS NP_310553.1 15831780 916568 complement(2503402..2503611) 1 NC_002695.1 hypothetical protein 2503611 916568 ECs2526 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310553.1 2503402 R 386585 CDS NP_310554.1 15831781 912501 2503877..2504848 1 NC_002695.1 similar to MANX_ECOLI gi|1788120 (conserved in Escherichia coli K-12); PTS system mannose-specific transporter subunit IIAB 2504848 912501 ECs2527 Escherichia coli O157:H7 str. Sakai PTS system mannose-specific transporter subunit IIAB NP_310554.1 2503877 D 386585 CDS NP_310555.1 15831782 912707 2504911..2505711 1 NC_002695.1 similar to MANY_ECOLI gi|1788121 (conserved in Escherichia coli K-12); mannose-specific PTS enzyme IIC 2505711 912707 ECs2528 Escherichia coli O157:H7 str. Sakai mannose-specific PTS enzyme IIC NP_310555.1 2504911 D 386585 CDS NP_310556.3 162139716 914171 2505715..2506575 1 NC_002695.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2506575 914171 ECs2529 Escherichia coli O157:H7 str. Sakai PTS system mannose-specific transporter subunit IID NP_310556.3 2505715 D 386585 CDS NP_310557.1 15831784 912870 2506630..2507088 1 NC_002695.1 similar to B1820_ECOLI gi|1788123 (conserved in Escherichia coli K-12); hypothetical protein 2507088 912870 ECs2530 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310557.1 2506630 D 386585 CDS NP_310558.1 15831785 913981 2507464..2508084 1 NC_002695.1 membrane protein YebN; hypothetical protein 2508084 913981 ECs2531 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310558.1 2507464 D 386585 CDS NP_310559.1 15831786 912722 complement(2508081..2508890) 1 NC_002695.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 2508890 rrmA 912722 rrmA Escherichia coli O157:H7 str. Sakai 23S rRNA methyltransferase NP_310559.1 2508081 R 386585 CDS NP_310560.1 15831787 912295 complement(2509056..2509265) 1 NC_002695.1 similar to CSPC_ECOLI gi|1788126 (conserved in Escherichia coli K-12); cold shock-like protein CspC 2509265 912295 ECs2533 Escherichia coli O157:H7 str. Sakai cold shock-like protein CspC NP_310560.1 2509056 R 386585 CDS NP_310561.1 15831788 913814 complement(2509278..2509421) 1 NC_002695.1 similar to B1824_ECOLI gi|1788127 (conserved in Escherichia coli K-12); hypothetical protein 2509421 913814 ECs2534 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310561.1 2509278 R 386585 CDS NP_310562.1 15831789 912296 complement(2510090..2510377) 1 NC_002695.1 similar to B1825_ECOLI gi|1788128 (conserved in Escherichia coli K-12); hypothetical protein 2510377 912296 ECs2535 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310562.1 2510090 R 386585 CDS NP_310563.1 15831790 913625 complement(2510452..2510595) 1 NC_002695.1 similar to B1826_ECOLI gi|1788130 (conserved in Escherichia coli K-12); hypothetical protein 2510595 913625 ECs2536 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310563.1 2510452 R 386585 CDS NP_944546.1 38704020 2693823 2510779..2510994 1 NC_002695.1 hypothetical protein 2510994 2693823 ECs5463 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944546.1 2510779 D 386585 CDS NP_310564.1 15831791 912739 complement(2511138..2511929) 1 NC_002695.1 similar to B1827_ECOLI gi|1788131 (conserved in Escherichia coli K-12); regulator 2511929 912739 ECs2537 Escherichia coli O157:H7 str. Sakai regulator NP_310564.1 2511138 R 386585 CDS NP_310565.2 38704021 912795 2512106..2513479 1 NC_002695.1 similar to B1828_ECOLI gi|1788132 (conserved in Escherichia coli K-12); transporter 2513479 912795 ECs2538 Escherichia coli O157:H7 str. Sakai transporter NP_310565.2 2512106 D 386585 CDS NP_310566.1 15831793 912682 complement(2513525..2514406) 1 NC_002695.1 metalloprotease; heat shock protein HtpX 2514406 912682 ECs2539 Escherichia coli O157:H7 str. Sakai heat shock protein HtpX NP_310566.1 2513525 R 386585 CDS NP_310567.1 15831794 912964 complement(2514598..2516646) 1 NC_002695.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 2516646 912964 ECs2540 Escherichia coli O157:H7 str. Sakai carboxy-terminal protease NP_310567.1 2514598 R 386585 CDS NP_310568.1 15831795 912783 complement(2516666..2517364) 1 NC_002695.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 2517364 912783 ECs2541 Escherichia coli O157:H7 str. Sakai solute/DNA competence effector NP_310568.1 2516666 R 386585 CDS NP_310569.2 38704022 915160 complement(2517461..2517958) 1 NC_002695.1 similar to B1832_ECOLI gi|1788136 (conserved in Escherichia coli K-12); hypothetical protein 2517958 915160 ECs2542 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310569.2 2517461 R 386585 CDS NP_310570.1 15831797 912855 2518088..2519371 1 NC_002695.1 similar to B1833_ECOLI gi|1788137 (conserved in Escherichia coli K-12); hypothetical protein 2519371 912855 ECs2543 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310570.1 2518088 D 386585 CDS NP_310571.1 15831798 914177 2519334..2521973 1 NC_002695.1 similar to B1834_ECOLI gi|1788138 (conserved in Escherichia coli K-12); hypothetical protein 2521973 914177 ECs2544 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310571.1 2519334 D 386585 CDS NP_310572.1 15831799 915363 2522048..2523493 1 NC_002695.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2523493 yebU 915363 yebU Escherichia coli O157:H7 str. Sakai rRNA (cytosine-C(5)-)-methyltransferase RsmF NP_310572.1 2522048 D 386585 CDS NP_310573.1 15831800 914904 2523596..2523847 1 NC_002695.1 similar to B1836_ECOLI gi|1788141 (conserved in Escherichia coli K-12); hypothetical protein 2523847 914904 ECs2546 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310573.1 2523596 D 386585 CDS NP_310574.1 15831801 914875 2523868..2524143 1 NC_002695.1 similar to B1837_ECOLI gi|1788142 (conserved in Escherichia coli K-12); hypothetical protein 2524143 914875 ECs2547 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310574.1 2523868 D 386585 CDS NP_310575.2 38704023 912809 complement(2524144..2524800) 1 NC_002695.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 2524800 pphA 912809 pphA Escherichia coli O157:H7 str. Sakai serine/threonine protein phosphatase 1 NP_310575.2 2524144 R 386585 CDS NP_310576.1 15831803 915046 complement(2525196..2525537) 1 NC_002695.1 similar to B1839_ECOLI gi|1788144 (conserved in Escherichia coli K-12); hypothetical protein 2525537 915046 ECs2549 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310576.1 2525196 R 386585 CDS NP_310577.1 15831804 912377 complement(2525550..2526422) 1 NC_002695.1 similar to B1840_ECOLI gi|1788145 (conserved in Escherichia coli K-12); resistance protein 2526422 912377 ECs2550 Escherichia coli O157:H7 str. Sakai resistance protein NP_310577.1 2525550 R 386585 CDS NP_310578.1 15831805 914269 complement(2526426..2526800) 1 NC_002695.1 similar to B1841_ECOLI gi|1788146 (conserved in Escherichia coli K-12); hypothetical protein 2526800 914269 ECs2551 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310578.1 2526426 R 386585 CDS NP_310579.1 15831806 913059 2526939..2527169 1 NC_002695.1 similar to HOLE_ECOLI gi|1788147 (conserved in Escherichia coli K-12); DNA polymerase III subunit theta 2527169 913059 ECs2552 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit theta NP_310579.1 2526939 D 386585 CDS NP_310580.1 15831807 913638 2527271..2527927 1 NC_002695.1 similar to B1843_ECOLI gi|1788148 (conserved in Escherichia coli K-12); hypothetical protein 2527927 913638 ECs2553 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310580.1 2527271 D 386585 CDS NP_310581.1 15831808 913055 2527951..2528613 1 NC_002695.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2528613 913055 ECs2554 Escherichia coli O157:H7 str. Sakai exodeoxyribonuclease X NP_310581.1 2527951 D 386585 CDS NP_310582.1 15831809 912379 complement(2528610..2530670) 1 NC_002695.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 2530670 912379 ECs2555 Escherichia coli O157:H7 str. Sakai protease 2 NP_310582.1 2528610 R 386585 CDS NP_310583.1 15831810 913246 complement(2530879..2531538) 1 NC_002695.1 similar to YEBE_ECOLI gi|1788151 (conserved in Escherichia coli K-12); hypothetical protein 2531538 913246 ECs2556 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310583.1 2530879 R 386585 CDS NP_310584.1 15831811 914104 complement(2531865..2532233) 1 NC_002695.1 secreted protein; unknown function; hypothetical protein 2532233 914104 ECs2557 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310584.1 2531865 R 386585 CDS NP_310585.1 15831812 912752 complement(2532288..2532578) 1 NC_002695.1 similar to YEBG_ECOLI gi|1788153 (conserved in Escherichia coli K-12); DNA damage-inducible protein YebG 2532578 912752 ECs2558 Escherichia coli O157:H7 str. Sakai DNA damage-inducible protein YebG NP_310585.1 2532288 R 386585 CDS NP_310586.1 15831813 912498 2532712..2533890 1 NC_002695.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2533890 purT 912498 purT Escherichia coli O157:H7 str. Sakai phosphoribosylglycinamide formyltransferase 2 NP_310586.1 2532712 D 386585 CDS NP_310587.1 15831814 912650 complement(2533946..2534587) 1 NC_002695.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 2534587 912650 ECs2560 Escherichia coli O157:H7 str. Sakai keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_310587.1 2533946 R 386585 CDS NP_310588.1 15831815 912867 complement(2534624..2536435) 1 NC_002695.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 2536435 912867 ECs2561 Escherichia coli O157:H7 str. Sakai phosphogluconate dehydratase NP_310588.1 2534624 R 386585 CDS NP_310589.1 15831816 912956 complement(2536670..2538145) 1 NC_002695.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2538145 912956 ECs2562 Escherichia coli O157:H7 str. Sakai glucose-6-phosphate 1-dehydrogenase NP_310589.1 2536670 R 386585 CDS NP_310590.1 15831817 912646 2538483..2539352 1 NC_002695.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2539352 912646 ECs2563 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator HexR NP_310590.1 2538483 D 386585 CDS NP_310591.1 15831818 913541 2539480..2540922 1 NC_002695.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2540922 913541 ECs2564 Escherichia coli O157:H7 str. Sakai pyruvate kinase NP_310591.1 2539480 D 386585 CDS NP_310592.1 15831819 913553 complement(2541053..2542024) 1 NC_002695.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2542024 913553 ECs2565 Escherichia coli O157:H7 str. Sakai lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase NP_310592.1 2541053 R 386585 CDS NP_310593.2 162139785 913569 complement(2542144..2543466) 1 NC_002695.1 similar to YEBA_ECOLI gi|1788162 (conserved in Escherichia coli K-12); hypothetical protein 2543466 913569 ECs2566 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310593.2 2542144 R 386585 CDS NP_310594.3 162139717 912362 complement(2543482..2544414) 1 NC_002695.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 2544414 znuA 912362 znuA Escherichia coli O157:H7 str. Sakai high-affinity zinc transporter periplasmic protein NP_310594.3 2543482 R 386585 CDS NP_310595.1 15831822 913529 2544493..2545248 1 NC_002695.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2545248 znuC 913529 znuC Escherichia coli O157:H7 str. Sakai high-affinity zinc transporter ATPase NP_310595.1 2544493 D 386585 CDS NP_310596.1 15831823 916919 2545245..2546030 1 NC_002695.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2546030 znuB 916919 znuB Escherichia coli O157:H7 str. Sakai high-affinity zinc transporter membrane protein NP_310596.1 2545245 D 386585 CDS NP_310597.1 15831824 913568 complement(2546276..2547286) 1 NC_002695.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2547286 ruvB 913568 ruvB Escherichia coli O157:H7 str. Sakai Holliday junction DNA helicase RuvB NP_310597.1 2546276 R 386585 CDS NP_310598.1 15831825 913515 complement(2547295..2547906) 1 NC_002695.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2547906 ruvA 913515 ruvA Escherichia coli O157:H7 str. Sakai Holliday junction DNA helicase RuvA NP_310598.1 2547295 R 386585 CDS NP_310599.2 162139784 913539 2548181..2548783 1 NC_002695.1 similar to YEBB_ECOLI gi|1788169 (conserved in Escherichia coli K-12); hypothetical protein 2548783 913539 ECs2572 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310599.2 2548181 D 386585 CDS NP_310600.1 15831827 912572 complement(2548785..2549306) 1 NC_002695.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2549306 ruvC 912572 ruvC Escherichia coli O157:H7 str. Sakai Holliday junction resolvase NP_310600.1 2548785 R 386585 CDS NP_310601.1 15831828 912378 complement(2549341..2550081) 1 NC_002695.1 similar to YEBC_ECOLI gi|1788171 (conserved in Escherichia coli K-12); hypothetical protein 2550081 912378 ECs2574 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310601.1 2549341 R 386585 CDS NP_310602.1 15831829 914189 complement(2550110..2550562) 1 NC_002695.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 2550562 ntpA 914189 ntpA Escherichia coli O157:H7 str. Sakai dATP pyrophosphohydrolase NP_310602.1 2550110 R 386585 CDS NP_310603.1 15831830 914186 complement(2550680..2552452) 1 NC_002695.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2552452 aspS 914186 aspS Escherichia coli O157:H7 str. Sakai aspartyl-tRNA synthetase NP_310603.1 2550680 R 386585 CDS NP_310604.2 162139783 914157 2552762..2553328 1 NC_002695.1 similar to YECD_ECOLI gi|1788174 (conserved in Escherichia coli K-12); hypothetical protein 2553328 914157 ECs2577 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310604.2 2552762 D 386585 CDS NP_310605.1 15831832 913980 2553325..2554143 1 NC_002695.1 similar to YECE_ECOLI gi|1788175 (conserved in Escherichia coli K-12); hypothetical protein 2554143 913980 ECs2578 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310605.1 2553325 D 386585 CDS NP_310606.2 38704025 913033 2554196..2554591 1 NC_002695.1 similar to YECN_ECOLI gi|1788176 (conserved in Escherichia coli K-12); hypothetical protein 2554591 913033 ECs2579 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310606.2 2554196 D 386585 CDS NP_310607.1 15831834 912510 2554632..2555375 1 NC_002695.1 similar to YECO_ECOLI gi|1788177 (conserved in Escherichia coli K-12); hypothetical protein 2555375 912510 ECs2580 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310607.1 2554632 D 386585 CDS NP_310608.1 15831835 914170 2555372..2556343 1 NC_002695.1 similar to YECP_ECOLI gi|1788178 (conserved in Escherichia coli K-12); hypothetical protein 2556343 914170 ECs2581 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310608.1 2555372 D 386585 CDS NP_310609.2 38704026 914087 complement(2556508..2558937) 1 NC_002695.1 similar to BISZ_ECOLI gi|1788180 (conserved in Escherichia coli K-12); biotin sulfoxide reductase 2558937 914087 ECs2582 Escherichia coli O157:H7 str. Sakai biotin sulfoxide reductase NP_310609.2 2556508 R 386585 CDS NP_310610.1 15831837 912611 complement(2558962..2560062) 1 NC_002695.1 similar to YECK_ECOLI gi|1788181 (conserved in Escherichia coli K-12); cytochrome C-type protein 2560062 912611 ECs2583 Escherichia coli O157:H7 str. Sakai cytochrome C-type protein NP_310610.1 2558962 R 386585 CDS NP_310611.2 38704027 912830 complement(2560450..2561196) 1 NC_002695.1 similar to CUTC_ECOLI gi|1788182 (conserved in Escherichia coli K-12); copper homeostasis protein CutC 2561196 912830 ECs2584 Escherichia coli O157:H7 str. Sakai copper homeostasis protein CutC NP_310611.2 2560450 R 386585 CDS NP_310612.2 38704028 913954 complement(2561210..2561776) 1 NC_002695.1 similar to YECM_ECOLI gi|1788183 (conserved in Escherichia coli K-12); hypothetical protein 2561776 913954 ECs2585 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310612.2 2561210 R 386585 CDS NP_310613.1 15831840 912519 2561992..2563725 1 NC_002695.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2563725 argS 912519 argS Escherichia coli O157:H7 str. Sakai arginyl-tRNA synthetase NP_310613.1 2561992 D 386585 CDS NP_310614.1 15831841 913572 2563902..2564390 1 NC_002695.1 similar to YECT_ECOLI gi|1788185 (conserved in Escherichia coli K-12); hypothetical protein 2564390 913572 ECs2587 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310614.1 2563902 D 386585 CDS NP_310615.1 15831842 912570 complement(2564510..2564902) 1 NC_002695.1 similar to FLHE_ECOLI gi|1788186 (conserved in Escherichia coli K-12); flagellar protein 2564902 912570 ECs2588 Escherichia coli O157:H7 str. Sakai flagellar protein NP_310615.1 2564510 R 386585 CDS NP_310616.1 15831843 914214 complement(2564902..2566980) 1 NC_002695.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 2566980 flhA 914214 flhA Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FlhA NP_310616.1 2564902 R 386585 CDS NP_310617.1 15831844 912385 complement(2566973..2568121) 1 NC_002695.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 2568121 flhB 912385 flhB Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FlhB NP_310617.1 2566973 R 386585 CDS NP_310618.1 15831845 912565 complement(2568323..2568967) 1 NC_002695.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis protein CheZ 2568967 912565 ECs2591 Escherichia coli O157:H7 str. Sakai chemotaxis protein CheZ NP_310618.1 2568323 R 386585 CDS NP_310619.1 15831846 914203 complement(2568978..2569367) 1 NC_002695.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 2569367 914203 ECs2592 Escherichia coli O157:H7 str. Sakai chemotaxis regulatory protein CheY NP_310619.1 2568978 R 386585 CDS NP_310620.1 15831847 913533 complement(2569382..2570431) 1 NC_002695.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 2570431 913533 ECs2593 Escherichia coli O157:H7 str. Sakai chemotaxis-specific methylesterase NP_310620.1 2569382 R 386585 CDS NP_310621.1 15831848 914148 complement(2570434..2571294) 1 NC_002695.1 methylates the MCP; chemotaxis methyltransferase CheR 2571294 914148 ECs2594 Escherichia coli O157:H7 str. Sakai chemotaxis methyltransferase CheR NP_310621.1 2570434 R 386585 CDS NP_310622.1 15831849 914196 complement(2571313..2572914) 1 NC_002695.1 mediates taxis toward dipeptides; methyl-accepting protein IV 2572914 914196 ECs2595 Escherichia coli O157:H7 str. Sakai methyl-accepting protein IV NP_310622.1 2571313 R 386585 CDS NP_310623.1 15831850 914160 complement(2572960..2574621) 1 NC_002695.1 similar to TAR_ECOLI gi|1788195 (conserved in Escherichia coli K-12); methyl-accepting chemotaxis protein II 2574621 914160 ECs2596 Escherichia coli O157:H7 str. Sakai methyl-accepting chemotaxis protein II NP_310623.1 2572960 R 386585 CDS NP_310624.1 15831851 914106 complement(2574764..2575267) 1 NC_002695.1 similar to CHEW_ECOLI gi|1788196 (conserved in Escherichia coli K-12); purine-binding chemotaxis protein 2575267 914106 ECs2597 Escherichia coli O157:H7 str. Sakai purine-binding chemotaxis protein NP_310624.1 2574764 R 386585 CDS NP_310625.1 15831852 914221 complement(2575288..2577252) 1 NC_002695.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 2577252 914221 ECs2598 Escherichia coli O157:H7 str. Sakai chemotaxis protein CheA NP_310625.1 2575288 R 386585 CDS NP_310626.1 15831853 912569 complement(2577257..2578183) 1 NC_002695.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 2578183 motB 912569 motB Escherichia coli O157:H7 str. Sakai flagellar motor protein MotB NP_310626.1 2577257 R 386585 CDS NP_310627.1 15831854 912582 complement(2578180..2579067) 1 NC_002695.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 2579067 912582 ECs2600 Escherichia coli O157:H7 str. Sakai flagellar motor protein MotA NP_310627.1 2578180 R 386585 CDS NP_310628.1 15831855 913689 complement(2579194..2579772) 1 NC_002695.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 2579772 913689 ECs2601 Escherichia coli O157:H7 str. Sakai transcriptional activator FlhC NP_310628.1 2579194 R 386585 CDS NP_310629.2 38704029 913958 complement(2579775..2580125) 1 NC_002695.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 2580125 913958 ECs2602 Escherichia coli O157:H7 str. Sakai transcriptional activator FlhD NP_310629.2 2579775 R 386585 CDS NP_310630.1 15831857 915311 2580905..2581333 1 NC_002695.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2581333 915311 ECs2603 Escherichia coli O157:H7 str. Sakai universal stress protein UspC NP_310630.1 2580905 D 386585 CDS NP_310631.1 15831858 912524 complement(2581340..2582764) 1 NC_002695.1 similar to OTSA_ECOLI gi|1788206 (conserved in Escherichia coli K-12); trehalose-6-phosphate synthase 2582764 912524 ECs2604 Escherichia coli O157:H7 str. Sakai trehalose-6-phosphate synthase NP_310631.1 2581340 R 386585 CDS NP_310632.1 15831859 913656 complement(2582739..2583539) 1 NC_002695.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 2583539 913656 ECs2605 Escherichia coli O157:H7 str. Sakai trehalose-6-phosphate phosphatase NP_310632.1 2582739 R 386585 CDS NP_310635.1 15831862 913724 complement(2584707..2586221) 1 NC_002695.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 2586221 araG 913724 araG Escherichia coli O157:H7 str. Sakai L-arabinose transporter ATP-binding protein NP_310635.1 2584707 R 386585 CDS NP_310636.1 15831863 912678 complement(2586291..2587280) 1 NC_002695.1 similar to ARAF_ECOLI gi|1788211 (conserved in Escherichia coli K-12); L-arabinose-binding periplasmic protein 2587280 912678 ECs2609 Escherichia coli O157:H7 str. Sakai L-arabinose-binding periplasmic protein NP_310636.1 2586291 R 386585 CDS NP_310637.1 15831864 913020 2588077..2588580 1 NC_002695.1 similar to YECI_ECOLI gi|1788212 (conserved in Escherichia coli K-12); ferritin 2588580 913020 ECs2610 Escherichia coli O157:H7 str. Sakai ferritin NP_310637.1 2588077 D 386585 CDS NP_944547.1 38704030 2693754 complement(2588660..2588911) 1 NC_002695.1 hypothetical protein 2588911 2693754 ECs5464 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944547.1 2588660 R 386585 CDS NP_310639.1 15831866 913636 2589374..2589697 1 NC_002695.1 similar to B1904_ECOLI gi|1788215 (conserved in Escherichia coli K-12); hypothetical protein 2589697 913636 ECs2612 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310639.1 2589374 D 386585 CDS NP_310640.1 15831867 913633 2589868..2590365 1 NC_002695.1 cytoplasmic iron storage protein; ferritin 2590365 913633 ECs2613 Escherichia coli O157:H7 str. Sakai ferritin NP_310640.1 2589868 D 386585 CDS NP_310641.1 15831868 913752 complement(2590402..2590641) 1 NC_002695.1 similar to YECH_ECOLI gi|1788217 (conserved in Escherichia coli K-12); hypothetical protein 2590641 913752 ECs2614 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310641.1 2590402 R 386585 CDS NP_310642.1 15831869 914224 2590833..2592044 1 NC_002695.1 similar to TYRP_ECOLI gi|1788218 (conserved in Escherichia coli K-12); tyrosine-specific transporter 2592044 914224 ECs2615 Escherichia coli O157:H7 str. Sakai tyrosine-specific transporter NP_310642.1 2590833 D 386585 CDS NP_310643.1 15831870 914153 complement(2592106..2592771) 1 NC_002695.1 similar to YECA_ECOLI gi|1788219 (conserved in Escherichia coli K-12); hypothetical protein 2592771 914153 ECs2616 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310643.1 2592106 R 386585 CDS NP_310644.1 15831871 914199 complement(2593128..2594129) 1 NC_002695.1 similar to integrases e.g. [Bacteriophage S2] gi|1679807|emb|CAA96221.1; integrase 2594129 914199 ECs2617 Escherichia coli O157:H7 str. Sakai integrase NP_310644.1 2593128 R 386585 CDS NP_310645.1 15831872 914225 complement(2594135..2594482) 1 NC_002695.1 similar to hypothetical protein b1839 [Escherichia coli] gi|7451973|pir||G64945; hypothetical protein 2594482 914225 ECs2618 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310645.1 2594135 R 386585 CDS NP_310646.1 15831873 912566 complement(2594512..2595162) 1 NC_002695.1 similar to cell division protein Div [Escherichia coli] gi|2494741|sp|Q11185|YPD5_CAEEL; hypothetical protein 2595162 912566 ECs2619 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310646.1 2594512 R 386585 CDS NP_310647.1 15831874 912489 complement(2595178..2595582) 1 NC_002695.1 similar to transcriptional regulators e.g. [Neisseria meningitidis] gi|7226247|gb|AAF41408.1; transcriptional regulator 2595582 912489 ECs2620 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_310647.1 2595178 R 386585 CDS NP_944548.1 38704031 2693755 2595658..2595864 1 NC_002695.1 hypothetical protein 2595864 2693755 ECs5465 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944548.1 2595658 D 386585 CDS NP_310649.1 15831876 914213 2595881..2596084 1 NC_002695.1 similar to DNA-binding protein Cox [Vibrio cholerae Bacteriophage K139] gi|4530499|gb|AAD22064.1, phage hypothetical proteins e.g. [Bacteriophage S2] gi|1679810|; DNA-binding protein 2596084 914213 ECs2622 Escherichia coli O157:H7 str. Sakai DNA-binding protein NP_310649.1 2595881 D 386585 CDS NP_310650.1 15831877 912604 2596106..2596456 1 NC_002695.1 hypothetical protein 2596456 912604 ECs2623 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310650.1 2596106 D 386585 CDS NP_310651.1 15831878 912473 2596467..2596745 1 NC_002695.1 hypothetical protein 2596745 912473 ECs2624 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310651.1 2596467 D 386585 CDS NP_310652.1 15831879 913540 2596757..2596999 1 NC_002695.1 hypothetical protein 2596999 913540 ECs2625 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310652.1 2596757 D 386585 CDS NP_310653.1 15831880 914065 2597202..2597618 1 NC_002695.1 hypothetical protein 2597618 914065 ECs2626 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310653.1 2597202 D 386585 CDS NP_310654.1 15831881 914006 2597642..2597845 1 NC_002695.1 hypothetical protein 2597845 914006 ECs2627 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310654.1 2597642 D 386585 CDS NP_310655.1 15831882 916180 2597842..2598108 1 NC_002695.1 hypothetical protein 2598108 916180 ECs2628 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310655.1 2597842 D 386585 CDS NP_310656.1 15831883 913897 2598105..2598404 1 NC_002695.1 hypothetical protein 2598404 913897 ECs2629 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310656.1 2598105 D 386585 CDS NP_310658.1 15831885 913749 2598727..2598957 1 NC_002695.1 similar to derepression protein epsilon [Bacteriophage P4] gi|137833|sp|P05463|VEPS_BPP4; derepression protein 2598957 913749 ECs2631 Escherichia coli O157:H7 str. Sakai derepression protein NP_310658.1 2598727 D 386585 CDS NP_310659.1 15831886 914059 2599030..2599395 1 NC_002695.1 hypothetical protein 2599395 914059 ECs2632 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310659.1 2599030 D 386585 CDS NP_310660.1 15831887 914184 2599540..2602224 1 NC_002695.1 similar to replication proteins e.g. GpA [Bacteriophage 186] gi|1351406|sp|P41064|VPA_BP186; phage replication protein 2602224 914184 ECs2633 Escherichia coli O157:H7 str. Sakai phage replication protein NP_310660.1 2599540 D 386585 CDS NP_310661.1 15831888 914147 2602301..2603260 1 NC_002695.1 similar to plasmid partition proteins e.g. par [Escherichia coli plasmid R1] gi|134954|sp|P11904|STBA_ECOLI; plasmid partition protein 2603260 914147 ECs2634 Escherichia coli O157:H7 str. Sakai plasmid partition protein NP_310661.1 2602301 D 386585 CDS NP_310662.1 15831889 914099 2603265..2603579 1 NC_002695.1 similar to plasmid partition proteins e.g. TSB [Escherichia coli plasmid NR1] gi|134956|sp|P11906|STBB_ECOLI; plasmid partition protein 2603579 914099 ECs2635 Escherichia coli O157:H7 str. Sakai plasmid partition protein NP_310662.1 2603265 D 386585 CDS NP_310663.1 15831890 912558 complement(2603599..2604288) 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 2604288 912558 ECs2636 Escherichia coli O157:H7 str. Sakai transposase NP_310663.1 2603599 R 386585 CDS NP_310664.1 15831891 912475 complement(2604288..2604614) 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical proteins in insertion sequences e.g. [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 2604614 912475 ECs2637 Escherichia coli O157:H7 str. Sakai transposase NP_310664.1 2604288 R 386585 CDS NP_310665.1 15831892 912487 complement(2605245..2605721) 1 NC_002695.1 similar to hypothetical proteins e.g. orf20 [Escherichia coli plasmid pB171] gi|6009396|dbj|BAA84855.1; hypothetical protein 2605721 912487 ECs2638 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310665.1 2605245 R 386585 CDS NP_310666.2 38704032 914145 complement(2605974..2606468) 1 NC_002695.1 similar to tail proteins e.g. F protein [Bacteriophage 186] gi|3337273|gb|AAC34171.1; tail protein 2606468 914145 ECs2639 Escherichia coli O157:H7 str. Sakai tail protein NP_310666.2 2605974 R 386585 CDS NP_310669.1 15831896 914093 complement(2609265..2609501) 1 NC_002695.1 similar to gi|3139111|gb|AAD03292.1; phage tail protein 2609501 914093 ECs2642 Escherichia coli O157:H7 str. Sakai phage tail protein NP_310669.1 2609265 R 386585 CDS NP_310670.1 15831897 912557 complement(2609429..2609794) 1 NC_002695.1 similar to tail protein e.g. GpE [Bacteriophage P2] gi|3139110|gb|AAD03291.1; tail protein 2609794 912557 ECs2643 Escherichia coli O157:H7 str. Sakai tail protein NP_310670.1 2609429 R 386585 CDS NP_310671.1 15831898 912318 complement(2609849..2610361) 1 NC_002695.1 similar to tail tube proteins e.g. tail protein FII [Bacteriophage 186] gi|139325|sp|P22502|VPF2_BPP2; tail tube protein 2610361 912318 ECs2644 Escherichia coli O157:H7 str. Sakai tail tube protein NP_310671.1 2609849 R 386585 CDS NP_310672.1 15831899 912336 complement(2610361..2611545) 1 NC_002695.1 similar to tail sheath proteins e.g. FI [Pseudomonas aeruginosa bacteriophage phiCTX] gi|4063795|dbj|BAA36249.1; tail sheath protein 2611545 912336 ECs2645 Escherichia coli O157:H7 str. Sakai tail sheath protein NP_310672.1 2610361 R 386585 CDS NP_310673.1 15831900 914185 2611703..2612026 1 NC_002695.1 similar to tail proteins e.g. GpD [Bacteriophage P2] gi|6136287|sp|P10312|VPD_BPP2; tail protein 2612026 914185 ECs2646 Escherichia coli O157:H7 str. Sakai tail protein NP_310673.1 2611703 D 386585 CDS NP_310677.1 15831904 913922 complement(2614540..2615088) 1 NC_002695.1 similar to PGSA_ECOLI gi|1788220 (conserved in Escherichia coli K-12); phosphatidylglycerophosphate synthetase 2615088 913922 ECs2650 Escherichia coli O157:H7 str. Sakai phosphatidylglycerophosphate synthetase NP_310677.1 2614540 R 386585 CDS NP_310678.2 38704033 913874 complement(2615145..2616977) 1 NC_002695.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2616977 uvrC 913874 uvrC Escherichia coli O157:H7 str. Sakai excinuclease ABC subunit C NP_310678.2 2615145 R 386585 CDS NP_310679.1 15831906 912605 complement(2616974..2617630) 1 NC_002695.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2617630 912605 ECs2652 Escherichia coli O157:H7 str. Sakai response regulator NP_310679.1 2616974 R 386585 CDS NP_310680.1 15831907 912374 2618089..2618313 1 NC_002695.1 similar to YECF_ECOLI gi|1788223 (conserved in Escherichia coli K-12); hypothetical protein 2618313 912374 ECs2653 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310680.1 2618089 D 386585 CDS NP_310681.1 15831908 912965 complement(2618381..2619103) 1 NC_002695.1 regulates genes involved in cell division; SdiA family transcriptional regulator 2619103 912965 ECs2654 Escherichia coli O157:H7 str. Sakai SdiA family transcriptional regulator NP_310681.1 2618381 R 386585 CDS NP_310682.1 15831909 913971 complement(2619333..2620085) 1 NC_002695.1 similar to YECC_ECOLI gi|1788225 (conserved in Escherichia coli K-12); amino-acid ABC transporter ATP-binding protein 2620085 913971 ECs2655 Escherichia coli O157:H7 str. Sakai amino-acid ABC transporter ATP-binding protein NP_310682.1 2619333 R 386585 CDS NP_310683.1 15831910 913751 complement(2620082..2620750) 1 NC_002695.1 similar to YECS_ECOLI gi|1788226 (conserved in Escherichia coli K-12); transport system permease 2620750 913751 ECs2656 Escherichia coli O157:H7 str. Sakai transport system permease NP_310683.1 2620082 R 386585 CDS NP_310686.1 15831913 914100 complement(2621855..2622655) 1 NC_002695.1 similar to FLIY_ECOLI gi|1788228 (conserved in Escherichia coli K-12); cystine transporter subunit 2622655 914100 ECs2659 Escherichia coli O157:H7 str. Sakai cystine transporter subunit NP_310686.1 2621855 R 386585 CDS NP_310687.1 15831914 913820 complement(2622743..2623330) 1 NC_002695.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2623330 913820 ECs2660 Escherichia coli O157:H7 str. Sakai flagella biosynthesis protein FliZ NP_310687.1 2622743 R 386585 CDS NP_310688.1 15831915 914052 complement(2623340..2624059) 1 NC_002695.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2624059 fliA 914052 fliA Escherichia coli O157:H7 str. Sakai flagellar biosynthesis sigma factor NP_310688.1 2623340 R 386585 CDS NP_310689.1 15831916 915172 complement(2624379..2626136) 1 NC_002695.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 2626136 915172 ECs2662 Escherichia coli O157:H7 str. Sakai flagellin NP_310689.1 2624379 R 386585 CDS NP_310690.1 15831917 913755 2626402..2627799 1 NC_002695.1 involved in flagellin assembly; flagellar capping protein 2627799 fliD 913755 fliD Escherichia coli O157:H7 str. Sakai flagellar capping protein NP_310690.1 2626402 D 386585 CDS NP_310691.1 15831918 912953 2627824..2628234 1 NC_002695.1 flagellin specific chaperone; flagellar protein FliS 2628234 fliS 912953 fliS Escherichia coli O157:H7 str. Sakai flagellar protein FliS NP_310691.1 2627824 D 386585 CDS NP_310692.1 15831919 912872 2628234..2628599 1 NC_002695.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2628599 912872 ECs2665 Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FliT NP_310692.1 2628234 D 386585 CDS NP_310693.1 15831920 912970 2628677..2630164 1 NC_002695.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2630164 912970 ECs2666 Escherichia coli O157:H7 str. Sakai alpha-amylase NP_310693.1 2628677 D 386585 CDS NP_310694.2 38704034 912941 complement(2630198..2630614) 1 NC_002695.1 similar to YEDD_ECOLI gi|1788237 (conserved in Escherichia coli K-12); hypothetical protein 2630614 912941 ECs2667 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310694.2 2630198 R 386585 CDS NP_310695.1 15831922 912742 2630798..2632003 1 NC_002695.1 similar to YEDE_ECOLI gi|1788238 (conserved in Escherichia coli K-12); hypothetical protein 2632003 912742 ECs2668 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310695.1 2630798 D 386585 CDS NP_310696.1 15831923 913714 2632000..2632233 1 NC_002695.1 similar to YEDF_ECOLI gi|1788239 (conserved in Escherichia coli K-12); hypothetical protein 2632233 913714 ECs2669 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310696.1 2632000 D 386585 CDS NP_310697.1 15831924 913923 2632342..2633010 1 NC_002695.1 similar to YEDK_ECOLI gi|1788240 (conserved in Escherichia coli K-12); hypothetical protein 2633010 913923 ECs2670 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310697.1 2632342 D 386585 CDS NP_310702.1 15831929 912779 2636986..2637264 1 NC_002695.1 similar to B1936_ECOLI gi|1788246 (conserved in Escherichia coli K-12); hypothetical protein 2637264 912779 ECs2675 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310702.1 2636986 D 386585 CDS NP_310703.1 15831930 912495 complement(2637184..2637498) 1 NC_002695.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2637498 fliE 912495 fliE Escherichia coli O157:H7 str. Sakai flagellar hook-basal body protein FliE NP_310703.1 2637184 R 386585 CDS NP_310704.1 15831931 912989 2637713..2639371 1 NC_002695.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2639371 fliF 912989 fliF Escherichia coli O157:H7 str. Sakai flagellar MS-ring protein NP_310704.1 2637713 D 386585 CDS NP_310705.1 15831932 912982 2639364..2640359 1 NC_002695.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2640359 fliG 912982 fliG Escherichia coli O157:H7 str. Sakai flagellar motor switch protein G NP_310705.1 2639364 D 386585 CDS NP_310706.2 162139782 913760 2640352..2641038 1 NC_002695.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2641038 fliH 913760 fliH Escherichia coli O157:H7 str. Sakai flagellar assembly protein H NP_310706.2 2640352 D 386585 CDS NP_310707.1 15831934 912799 2641100..2642473 1 NC_002695.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2642473 fliI 912799 fliI Escherichia coli O157:H7 str. Sakai flagellum-specific ATP synthase NP_310707.1 2641100 D 386585 CDS NP_310708.1 15831935 916514 2642492..2642935 1 NC_002695.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2642935 fliJ 916514 fliJ Escherichia coli O157:H7 str. Sakai flagellar biosynthesis chaperone NP_310708.1 2642492 D 386585 CDS NP_310709.1 15831936 913014 2642932..2644059 1 NC_002695.1 similar to FLIK_ECOLI gi|1788253 (conserved in Escherichia coli K-12); flagellar hook-length control protein 2644059 913014 ECs2682 Escherichia coli O157:H7 str. Sakai flagellar hook-length control protein NP_310709.1 2642932 D 386585 CDS NP_310710.1 15831937 913120 2644164..2644628 1 NC_002695.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2644628 fliL 913120 fliL Escherichia coli O157:H7 str. Sakai flagellar basal body-associated protein FliL NP_310710.1 2644164 D 386585 CDS NP_310711.1 15831938 913591 2644633..2645637 1 NC_002695.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2645637 fliM 913591 fliM Escherichia coli O157:H7 str. Sakai flagellar motor switch protein FliM NP_310711.1 2644633 D 386585 CDS NP_310712.1 15831939 913021 2645634..2646047 1 NC_002695.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2646047 fliN 913021 fliN Escherichia coli O157:H7 str. Sakai flagellar motor switch protein FliN NP_310712.1 2645634 D 386585 CDS NP_310713.2 38704035 913050 2646050..2646415 1 NC_002695.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2646415 913050 ECs2686 Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FliO NP_310713.2 2646050 D 386585 CDS NP_310714.1 15831941 913785 2646415..2647152 1 NC_002695.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2647152 fliP 913785 fliP Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FliP NP_310714.1 2646415 D 386585 CDS NP_310715.1 15831942 914194 2647162..2647431 1 NC_002695.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2647431 fliQ 914194 fliQ Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FliQ NP_310715.1 2647162 D 386585 CDS NP_310716.1 15831943 913551 2647439..2648224 1 NC_002695.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2648224 fliR 913551 fliR Escherichia coli O157:H7 str. Sakai flagellar biosynthesis protein FliR NP_310716.1 2647439 D 386585 CDS NP_310717.1 15831944 913009 2648514..2649137 1 NC_002695.1 similar to RCSA_ECOLI gi|1788262 (conserved in Escherichia coli K-12); transcriptional regulator for ctr capsule biosynthesis 2649137 913009 ECs2690 Escherichia coli O157:H7 str. Sakai transcriptional regulator for ctr capsule biosynthesis NP_310717.1 2648514 D 386585 CDS NP_310718.1 15831945 912856 complement(2649181..2649369) 1 NC_002695.1 similar to DSRB_ECOLI gi|1788263 (conserved in Escherichia coli K-12); hypothetical protein 2649369 912856 ECs2691 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310718.1 2649181 R 386585 CDS NP_310719.2 38704036 913583 2649529..2649759 1 NC_002695.1 similar to B1953_ECOLI gi|1788264 (conserved in Escherichia coli K-12); hypothetical protein 2649759 913583 ECs2692 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310719.2 2649529 D 386585 CDS NP_310720.1 15831947 913699 2650057..2650872 1 NC_002695.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2650872 913699 ECs2693 Escherichia coli O157:H7 str. Sakai mannosyl-3-phosphoglycerate phosphatase NP_310720.1 2650057 D 386585 CDS NP_310721.1 15831948 912776 complement(2650869..2652563) 1 NC_002695.1 similar to B1956_ECOLI gi|1788266 (conserved in Escherichia coli K-12); hypothetical protein 2652563 912776 ECs2694 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310721.1 2650869 R 386585 CDS NP_310722.1 15831949 913057 complement(2652734..2652916) 1 NC_002695.1 similar to B1957_ECOLI gi|1788267 (conserved in Escherichia coli K-12); hypothetical protein 2652916 913057 ECs2695 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310722.1 2652734 R 386585 CDS NP_310723.1 15831950 913412 complement(2652995..2653912) 1 NC_002695.1 similar to YEDI_ECOLI gi|1788268 (conserved in Escherichia coli K-12); hypothetical protein 2653912 913412 ECs2696 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310723.1 2652995 R 386585 CDS NP_310724.1 15831951 913482 2654085..2655005 1 NC_002695.1 similar to YEDA_ECOLI gi|1788269 (conserved in Escherichia coli K-12); hypothetical protein 2655005 913482 ECs2697 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310724.1 2654085 D 386585 CDS NP_310725.1 15831952 914207 complement(2654994..2655464) 1 NC_002695.1 similar to VSR_ECOLI gi|1788270 (conserved in Escherichia coli K-12); Vsr; DNA mismatch endonuclease 2655464 914207 ECs2698 Escherichia coli O157:H7 str. Sakai DNA mismatch endonuclease NP_310725.1 2654994 R 386585 CDS NP_310726.1 15831953 913056 complement(2655445..2656863) 1 NC_002695.1 similar to DCM_ECOLI gi|1788271 (conserved in Escherichia coli K-12); DNA cytosine methylase 2656863 913056 ECs2699 Escherichia coli O157:H7 str. Sakai DNA cytosine methylase NP_310726.1 2655445 R 386585 CDS NP_310727.1 15831954 913053 complement(2656930..2657625) 1 NC_002695.1 similar to YEDJ_ECOLI gi|1788273 (conserved in Escherichia coli K-12); hypothetical protein 2657625 913053 ECs2700 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310727.1 2656930 R 386585 CDS NP_310728.1 15831955 913006 complement(2657721..2658047) 1 NC_002695.1 similar to B1963_ECOLI gi|1788274 (conserved in Escherichia coli K-12); hypothetical protein 2658047 913006 ECs2701 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310728.1 2657721 R 386585 CDS NP_310729.1 15831956 913927 2658596..2659240 1 NC_002695.1 similar to B1964_ECOLI gi|1788275, B1965_ECOLI gi|1788276, OMPC_ECOLI gi|1788544; outer membrane protein 2659240 913927 ECs2702 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310729.1 2658596 D 386585 CDS NP_310730.1 15831957 913248 2659207..2659782 1 NC_002695.1 similar to B1965_ECOLI gi|1788276, outer membrane protein B1966_ECOLI gi|1788277; hypothetical protein 2659782 913248 ECs2703 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310730.1 2659207 D 386585 CDS NP_310731.1 15831958 912443 2659863..2660213 1 NC_002695.1 hypothetical protein 2660213 912443 ECs2704 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310731.1 2659863 D 386585 CDS NP_310732.1 15831959 912670 2660374..2661225 1 NC_002695.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2661225 912670 ECs2705 Escherichia coli O157:H7 str. Sakai chaperone protein HchA NP_310732.1 2660374 D 386585 CDS NP_310733.1 15831960 913474 complement(2661333..2662691) 1 NC_002695.1 similar to YEDV_ECOLI gi|1788279 (conserved in Escherichia coli K-12); 2-component sensor protein 2662691 913474 ECs2706 Escherichia coli O157:H7 str. Sakai 2-component sensor protein NP_310733.1 2661333 R 386585 CDS NP_310734.2 162139781 913174 complement(2662691..2663362) 1 NC_002695.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2663362 913174 ECs2707 Escherichia coli O157:H7 str. Sakai transcriptional regulatory protein YedW NP_310734.2 2662691 R 386585 CDS NP_310735.1 15831962 912669 2663495..2663908 1 NC_002695.1 similar to B1970_ECOLI gi|1788281 (conserved in Escherichia coli K-12); hypothetical protein 2663908 912669 ECs2708 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310735.1 2663495 D 386585 CDS NP_310736.1 15831963 912771 2664016..2665020 1 NC_002695.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2665020 912771 ECs2709 Escherichia coli O157:H7 str. Sakai sulfite oxidase subunit YedY NP_310736.1 2664016 D 386585 CDS NP_310737.1 15831964 914824 2665021..2665656 1 NC_002695.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2665656 914824 ECs2710 Escherichia coli O157:H7 str. Sakai sulfite oxidase subunit YedZ NP_310737.1 2665021 D 386585 CDS NP_310738.1 15831965 912711 2665913..2666563 1 NC_002695.1 similar to B1973_ECOLI gi|1788284 (conserved in Escherichia coli K-12); hypothetical protein 2666563 912711 ECs2711 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310738.1 2665913 D 386585 CDS NP_310739.1 15831966 912539 2666876..2667436 1 NC_002695.1 similar to YODB_ECOLI gi|1788286 (conserved in Escherichia coli K-12); cytochrome 2667436 912539 ECs2712 Escherichia coli O157:H7 str. Sakai cytochrome NP_310739.1 2666876 D 386585 CDS NP_310740.1 15831967 912515 2667460..2667702 1 NC_002695.1 hypothetical protein 2667702 912515 ECs2713 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310740.1 2667460 D 386585 CDS NP_310741.1 15831968 912496 2668573..2669226 1 NC_002695.1 hypothetical protein 2669226 912496 ECs2714 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310741.1 2668573 D 386585 CDS NP_310742.1 15831969 912330 2669551..2670564 1 NC_002695.1 secerted effector protein; similar to hypothetical proteins e.g. EspF [Escherichia coli strain B10] gi|6090818|gb|AAF03351.1|AF116900_2 ESPF_ECOLI; EspF-like protein 2670564 912330 ECs2715 Escherichia coli O157:H7 str. Sakai EspF-like protein NP_310742.1 2669551 D 386585 CDS NP_310743.1 15831970 912477 complement(2670690..2670959) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 2670959 912477 ECs2716 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310743.1 2670690 R 386585 CDS NP_310744.1 15831971 912550 complement(2670961..2672274) 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 2672274 912550 ECs2717 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_310744.1 2670961 R 386585 CDS NP_310745.1 15831972 913421 complement(2672339..2672938) 1 NC_002695.1 similar to Lom outer membrane protein precursors e.g. [prophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein 2672938 913421 ECs2718 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310745.1 2672339 R 386585 CDS NP_310748.1 15831975 913300 complement(2676725..2677402) 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 2677402 913300 ECs2721 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310748.1 2676725 R 386585 CDS NP_310749.1 15831976 914149 complement(2677300..2677869) 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 2677869 914149 ECs2722 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310749.1 2677300 R 386585 CDS NP_310750.1 15831977 912305 complement(2678054..2678752) 1 NC_002695.1 similar to minor tail proteins e.g. GpL [Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 2678752 912305 ECs2723 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310750.1 2678054 R 386585 CDS NP_310751.1 15831978 913283 complement(2678752..2679081) 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 2679081 913283 ECs2724 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310751.1 2678752 R 386585 CDS NP_310754.1 15831981 912621 complement(2681637..2681942) 1 NC_002695.1 bacteriophage tail component; similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein 2681942 912621 ECs2727 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310754.1 2681637 R 386585 CDS NP_310755.1 15831982 912612 complement(2682077..2682508) 1 NC_002695.1 bacteriophage tail component; similar to minor tail proteins e.g. GpG [Bacteriophage lambda]gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 2682508 912612 ECs2728 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310755.1 2682077 R 386585 CDS NP_310756.2 38704037 912893 complement(2682522..2683184) 1 NC_002695.1 hypothetical protein 2683184 912893 ECs2729 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310756.2 2682522 R 386585 CDS NP_310757.1 15831984 912485 complement(2683244..2683510) 1 NC_002695.1 bacteriophage head component; may be truncated; similar to major head proteins e.g. Gp7 [Bacteriophage 21] gi|547612|sp|P36270|HEAD_BPP21, gi|547612|sp|P36270; major head protein 2683510 912485 ECs2730 Escherichia coli O157:H7 str. Sakai major head protein NP_310757.1 2683244 R 386585 CDS NP_310758.1 15831985 912658 complement(2683568..2683915) 1 NC_002695.1 bacteriophage head component; similar to head decoration proteins e.g. Gpshp [Bacteriophage 21] gi|549437|sp|P36275|VSHP_BPP21; head decoration protein 2683915 912658 ECs2731 Escherichia coli O157:H7 str. Sakai head decoration protein NP_310758.1 2683568 R 386585 CDS NP_310759.1 15831986 913443 complement(2683952..2685457) 1 NC_002695.1 similar to minor head proteins e.g. head-tail preconnector Gp5 [Bacteriophage 21] gi|549296|sp|P36273|VG05_BPP21; contains scaffold protein; head-tail preconnector protein 2685457 913443 ECs2732 Escherichia coli O157:H7 str. Sakai head-tail preconnector protein NP_310759.1 2683952 R 386585 CDS NP_310760.1 15831987 915258 complement(2685447..2687039) 1 NC_002695.1 similar to portal proteins e.g. Gp5 [Bacteriophage 21] gi|549295|sp|P36272|VG04_BPP21; portal protein 2687039 915258 ECs2733 Escherichia coli O157:H7 str. Sakai portal protein NP_310760.1 2685447 R 386585 CDS NP_310761.1 15831988 913168 complement(2687036..2687242) 1 NC_002695.1 similar to phage proteins e.g. head completion protein Gp3 [Bacteriophage 21] gi|549294|sp|P36271|VG03_BPP21; head completion protein 2687242 913168 ECs2734 Escherichia coli O157:H7 str. Sakai head completion protein NP_310761.1 2687036 R 386585 CDS NP_310762.1 15831989 912708 complement(2687226..2689154) 1 NC_002695.1 similar to terminase large subunits e.g. Gp2 [Bacteriophage 21] gi|2851579|sp|P36693|TERL_BPP21; terminase large subunit 2689154 912708 ECs2735 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_310762.1 2687226 R 386585 CDS NP_310763.1 15831990 914026 complement(2689126..2689635) 1 NC_002695.1 similar to terminase small subunits e.g. Gp1 [Bacteriophage N15] gi|7444578|pir||T13087; terminase small subunit 2689635 914026 ECs2736 Escherichia coli O157:H7 str. Sakai terminase small subunit NP_310763.1 2689126 R 386585 CDS NP_310764.1 15831991 916099 complement(2690336..2690650) 1 NC_002695.1 similar to PerC (BfpW) [Escherichia coli] gi|1172431|sp|P43475|PERC_ECOLI; transcriptional regulator 2690650 916099 ECs2737 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_310764.1 2690336 R 386585 CDS NP_944549.1 38704038 2693832 complement(2690892..2691032) 1 NC_002695.1 hypothetical protein 2691032 2693832 ECs5470 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944549.1 2690892 R 386585 CDS NP_310765.1 15831992 912834 complement(2691115..2691582) 1 NC_002695.1 host cell lysis; similar to Rz endopeptidases e.g. [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1|; endopeptidase 2691582 912834 ECs2739 Escherichia coli O157:H7 str. Sakai endopeptidase NP_310765.1 2691115 R 386585 CDS NP_310767.1 15831994 912980 complement(2691734..2691916) 1 NC_002695.1 hypothetical protein 2691916 912980 ECs2740 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310767.1 2691734 R 386585 CDS NP_310768.1 15831995 915021 complement(2692072..2692605) 1 NC_002695.1 similar to s e.g. R protein [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1|; endolysin 2692605 915021 ECs2741 Escherichia coli O157:H7 str. Sakai endolysin NP_310768.1 2692072 R 386585 CDS NP_310769.1 15831996 914063 complement(2692656..2693000) 1 NC_002695.1 similar to YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 2693000 914063 ECs2742 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310769.1 2692656 R 386585 CDS NP_310770.1 15831997 912472 complement(2693005..2693211) 1 NC_002695.1 host cell lysis; similar to holins e.g. protein S [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1|; holin 2693211 912472 ECs2743 Escherichia coli O157:H7 str. Sakai holin NP_310770.1 2693005 R 386585 CDS NP_310771.1 15831998 914168 2693531..2693857 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 2693857 914168 ECs2744 Escherichia coli O157:H7 str. Sakai transposase NP_310771.1 2693531 D 386585 CDS NP_310772.1 15831999 913374 2693854..2694744 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 2694744 913374 ECs2745 Escherichia coli O157:H7 str. Sakai transposase NP_310772.1 2693854 D 386585 CDS NP_310773.1 15832000 916570 complement(2694826..2696676) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 2696676 916570 ECs2746 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310773.1 2694826 R 386585 CDS NP_310775.1 15832002 914183 complement(2696990..2697157) 1 NC_002695.1 hypothetical protein 2697157 914183 ECs2748 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310775.1 2696990 R 386585 CDS NP_310776.1 15832003 914021 complement(2697154..2697582) 1 NC_002695.1 similar to TerB proteins e.g. [Deinococcus radiodurans] gi|7473690|pir||C75302; hypothetical protein 2697582 914021 ECs2749 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310776.1 2697154 R 386585 CDS NP_310777.1 15832004 913869 complement(2698216..2698905) 1 NC_002695.1 similar to antiterminators e.g. protein Q [Bacteriophage 82] gi|132277|sp|P13870|REGQ_BP82; antiterminator 2698905 913869 ECs2750 Escherichia coli O157:H7 str. Sakai antiterminator NP_310777.1 2698216 R 386585 CDS NP_310778.1 15832005 914321 complement(2698902..2699261) 1 NC_002695.1 similar to Rus protein e.g. [Bacteriophage 82] gi|6901639|gb|AAF31142.1| GP67_BPHK97, Gp67 [Bacteriophage HK97] gi|6901639|gb|AAF31142.1|; crossover junction endodeoxyribonuclease 2699261 914321 ECs2751 Escherichia coli O157:H7 str. Sakai crossover junction endodeoxyribonuclease NP_310778.1 2698902 R 386585 CDS NP_310779.1 15832006 913345 complement(2699274..2700323) 1 NC_002695.1 similar to hypothetical proteins e.g. b1560 [Escherichia coli] gi|7466196|pir||C64911; hypothetical protein 2700323 913345 ECs2752 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310779.1 2699274 R 386585 CDS NP_310780.1 15832007 912507 complement(2700325..2700603) 1 NC_002695.1 similar to orf QD1 [Bacteriophage N15] gi|2564084|gb|AAB81659.1|; hypothetical protein 2700603 912507 ECs2753 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310780.1 2700325 R 386585 CDS NP_310781.1 15832008 912381 complement(2700771..2700983) 1 NC_002695.1 similar to Hok/Gef family e.g. MokW [Bacteriophage 933W] gi|4585453|gb|AAD25481.1|AF125520_76; prophage maintenance protein 2700983 912381 ECs2754 Escherichia coli O157:H7 str. Sakai prophage maintenance protein NP_310781.1 2700771 R 386585 CDS NP_310782.1 15832009 912367 complement(2701170..2701274) 1 NC_002695.1 hypothetical protein 2701274 912367 ECs2755 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310782.1 2701170 R 386585 CDS NP_310783.1 15832010 914311 complement(2701384..2701947) 1 NC_002695.1 similar to GP45 Bacteriophage N15 T13131, Escherichia coli H65009; hypothetical protein 2701947 914311 ECs2756 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310783.1 2701384 R 386585 CDS NP_310784.1 15832011 913017 complement(2702074..2702385) 1 NC_002695.1 hypothetical protein 2702385 913017 ECs2757 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310784.1 2702074 R 386585 CDS NP_310785.1 15832012 912315 complement(2702382..2702570) 1 NC_002695.1 hypothetical protein 2702570 912315 ECs2758 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310785.1 2702382 R 386585 CDS NP_310786.1 15832013 914801 complement(2702567..2702923) 1 NC_002695.1 hypothetical protein 2702923 914801 ECs2759 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310786.1 2702567 R 386585 CDS NP_310787.1 15832014 913965 complement(2702920..2703144) 1 NC_002695.1 hypothetical protein 2703144 913965 ECs2760 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310787.1 2702920 R 386585 CDS NP_310788.1 15832015 913776 complement(2703166..2703864) 1 NC_002695.1 similar to YdaW [Escherichia coli] gi|3025105|sp|P76066|YDAW_ECOLI; hypothetical protein 2703864 913776 ECs2761 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310788.1 2703166 R 386585 CDS NP_310789.1 15832016 913274 complement(2703899..2704561) 1 NC_002695.1 similar to replication proteins e.g. Gp14 [Bacteriophage phi-80] gi|137937|sp|P14814|VG14_BPPH8; phage replication protein 2704561 913274 ECs2762 Escherichia coli O157:H7 str. Sakai phage replication protein NP_310789.1 2703899 R 386585 CDS NP_310790.1 15832017 913970 complement(2704353..2705390) 1 NC_002695.1 similar to replication termination factor dnaT (primosomal protein I) [Escherichia coli] gi|1361001|pir||S56589; hypothetical protein 2705390 913970 ECs2763 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310790.1 2704353 R 386585 CDS NP_310791.1 15832018 914158 complement(2705459..2705884) 1 NC_002695.1 similar to YdaT [Escherichia coli] gi|3025103|sp|P76064|YDAT_ECOLI, regulatory protein CII [Bacteriophage phi-80] gi|133360|sp|P14820|RPC2_BPPH8; hypothetical protein 2705884 914158 ECs2764 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310791.1 2705459 R 386585 CDS NP_310792.1 15832019 912335 complement(2705881..2706108) 1 NC_002695.1 repressor; similar to DicC (repressor protein of division inhibition gene dicB) [Escherichia coli] gi|118633|sp|P06965|DICC_ECOLI; cell division control protein 2706108 912335 ECs2765 Escherichia coli O157:H7 str. Sakai cell division control protein NP_310792.1 2705881 R 386585 CDS NP_310793.1 15832020 913129 2706203..2706850 1 NC_002695.1 similar to repressor proteins e.g. C2 repressor [Bacteriophage P22] gi|133359|sp|P03035|RPC2_BPP22; repressor protein 2706850 913129 ECs2766 Escherichia coli O157:H7 str. Sakai repressor protein NP_310793.1 2706203 D 386585 CDS NP_310794.1 15832021 912468 2707125..2707277 1 NC_002695.1 hypothetical protein 2707277 912468 ECs2767 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310794.1 2707125 D 386585 CDS NP_310795.1 15832022 912649 2707758..2707946 1 NC_002695.1 similar to DicB protein [Escherichia coli] gi|2507009|sp|P09557|DICB_ECOLI; cell division inhibition protein 2707946 912649 ECs2768 Escherichia coli O157:H7 str. Sakai cell division inhibition protein NP_310795.1 2707758 D 386585 CDS NP_310796.1 15832023 912292 2707943..2708131 1 NC_002695.1 similar to hypothetical proteins e.g. YdfD [Escherichia coli] gi|140587|sp|P29010|YDFD_ECOLI; hypothetical protein 2708131 912292 ECs2769 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310796.1 2707943 D 386585 CDS NP_310797.1 15832024 913606 2708227..2710425 1 NC_002695.1 hypothetical protein 2710425 913606 ECs2770 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310797.1 2708227 D 386585 CDS NP_310798.1 15832025 912462 2710379..2710699 1 NC_002695.1 hypothetical protein 2710699 912462 ECs2771 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310798.1 2710379 D 386585 CDS NP_310799.1 15832026 912334 2710758..2710961 1 NC_002695.1 hypothetical protein 2710961 912334 ECs2772 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310799.1 2710758 D 386585 CDS NP_310800.1 15832027 913562 2710961..2711983 1 NC_002695.1 similar to integrases e.g. [Bacteriophage HK022] gi|138560|sp|P16407|VINT_BPHK0; integrase 2711983 913562 ECs2773 Escherichia coli O157:H7 str. Sakai integrase NP_310800.1 2710961 D 386585 CDS NP_310801.2 38704039 914176 2712219..2713016 1 NC_002695.1 similar to B1976_ECOLI gi|1788287 (conserved in Escherichia coli K-12); hypothetical protein 2713016 914176 ECs2774 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310801.2 2712219 D 386585 CDS NP_310802.1 15832029 914032 2713479..2717486 1 NC_002695.1 similar to B1978_ECOLI gi|1788288; may contain frameshift; hypothetical protein 2717486 914032 ECs2775 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310802.1 2713479 D 386585 CDS NP_310803.1 15832030 912369 2717452..2721489 1 NC_002695.1 similar to B1978_ECOLI gi|1788288; may contain frameshift; hypothetical protein 2721489 912369 ECs2776 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310803.1 2717452 D 386585 CDS NP_310804.1 15832031 912960 complement(2721751..2722803) 1 NC_002695.1 similar to B1980_ECOLI gi|1788291, B1979_ECOLI gi|1788290; hypothetical protein 2722803 912960 ECs2777 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310804.1 2721751 R 386585 CDS NP_310805.1 15832032 912841 2723117..2724433 1 NC_002695.1 similar to SHIA_ECOLI gi|1788292 (conserved in Escherichia coli K-12); shikimate transporter 2724433 912841 ECs2778 Escherichia coli O157:H7 str. Sakai shikimate transporter NP_310805.1 2723117 D 386585 CDS NP_310806.1 15832033 912716 2724535..2725989 1 NC_002695.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2725989 912716 ECs2779 Escherichia coli O157:H7 str. Sakai AMP nucleosidase NP_310806.1 2724535 D 386585 CDS NP_310807.1 15832034 912408 2726332..2727048 1 NC_002695.1 similar to B1983_ECOLI gi|1788294 (conserved in Escherichia coli K-12); hypothetical protein 2727048 912408 ECs2780 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310807.1 2726332 D 386585 CDS NP_310810.1 15832037 912516 complement(2729435..2730385) 1 NC_002695.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2730385 cbl 912516 cbl Escherichia coli O157:H7 str. Sakai transcriptional regulator Cbl NP_310810.1 2729435 R 386585 CDS NP_310811.1 15832038 912304 complement(2730487..2731404) 1 NC_002695.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2731404 912304 ECs2784 Escherichia coli O157:H7 str. Sakai nitrogen assimilation transcriptional regulator NP_310811.1 2730487 R 386585 CDS NP_310812.1 15832039 912693 complement(2731861..2732793) 1 NC_002695.1 similar to ERFK_ECOLI gi|1788299 (conserved in Escherichia coli K-12); hypothetical protein 2732793 912693 ECs2785 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310812.1 2731861 R 386585 CDS NP_310813.1 15832040 913061 complement(2732858..2733937) 1 NC_002695.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2733937 cobT 913061 cobT Escherichia coli O157:H7 str. Sakai nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_310813.1 2732858 R 386585 CDS NP_310814.1 15832041 913691 complement(2733949..2734692) 1 NC_002695.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2734692 cobS 913691 cobS Escherichia coli O157:H7 str. Sakai cobalamin synthase NP_310814.1 2733949 R 386585 CDS NP_310815.1 15832042 912633 complement(2734689..2735234) 1 NC_002695.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2735234 cobU 912633 cobU Escherichia coli O157:H7 str. Sakai adenosylcobinamide kinase NP_310815.1 2734689 R 386585 CDS NP_310816.1 15832043 913111 2735575..2735976 1 NC_002695.1 similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1|; hypothetical protein 2735976 913111 ECs2789 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310816.1 2735575 D 386585 CDS NP_310817.1 15832044 914247 2735973..2736320 1 NC_002695.1 similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1|; hypothetical protein 2736320 914247 ECs2790 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310817.1 2735973 D 386585 CDS NP_310818.1 15832045 913038 2736370..2737908 1 NC_002695.1 similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 2737908 913038 ECs2791 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310818.1 2736370 D 386585 CDS NP_310819.1 15832046 912399 2739356..2741503 1 NC_002695.1 similar to B1995_ECOLI gi|1788304; hypothetical protein 2741503 912399 ECs2792 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310819.1 2739356 D 386585 CDS NP_310821.1 15832048 912676 2741875..2742201 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to IS629 hypothetical proteins e.g. [Escherichia coli plasmid pO157] gi|7444868|pir||T00241; transposase 2742201 912676 ECs2794 Escherichia coli O157:H7 str. Sakai transposase NP_310821.1 2741875 D 386585 CDS NP_310822.1 15832049 913362 2742198..2743088 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to IS629 transposase [Escherichia coli plasmid pO157) gi|7443862|pir||T00240; transposase 2743088 913362 ECs2795 Escherichia coli O157:H7 str. Sakai transposase NP_310822.1 2742198 D 386585 CDS NP_310823.1 15832050 913043 2743072..2743953 1 NC_002695.1 similar to hypothetical proteins e.g. YjdA [Escherichia coli] gi|731985|sp|P16694|YJDA_ECOLI; hypothetical protein 2743953 913043 ECs2796 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310823.1 2743072 D 386585 CDS NP_310824.1 15832051 913052 2743950..2744855 1 NC_002695.1 similar to hypothetical protein YjcZ [Escherichia coli] gi|731984|sp|P39267|YJCZ_ECOLI; hypothetical protein 2744855 913052 ECs2797 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310824.1 2743950 D 386585 CDS NP_310825.1 15832052 912905 2744852..2745922 1 NC_002695.1 similar to hypothetical protein [Xanthomonas campestris] gi|6689533|emb|CAB65709.1|; hypothetical protein 2745922 912905 ECs2798 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310825.1 2744852 D 386585 CDS NP_310826.1 15832053 912654 2746058..2746741 1 NC_002695.1 hypothetical protein 2746741 912654 ECs2799 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310826.1 2746058 D 386585 CDS NP_310827.1 15832054 913073 2746757..2747167 1 NC_002695.1 hypothetical protein 2747167 913073 ECs2800 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310827.1 2746757 D 386585 CDS NP_310828.1 15832055 913032 2747388..2748209 1 NC_002695.1 similar to hypothetical proteins e.g. YafZ [Escherichia coli] gi|2495487|sp|P77206|YAFZ_ECOLI; hypothetical protein 2748209 913032 ECs2801 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310828.1 2747388 D 386585 CDS NP_310829.1 15832056 912574 2748291..2748770 1 NC_002695.1 similar to hypothetical proteins e.g. YfjX [Escherichia coli] gi|1723636|sp|P52139|YFJX_ECOLI, antirestriction proteins e.g. KlcA protein [plasmid RK2] gi|1730051|sp|P52603; antirestriction protein 2748770 912574 ECs2802 Escherichia coli O157:H7 str. Sakai antirestriction protein NP_310829.1 2748291 D 386585 CDS NP_310830.1 15832057 914222 2748785..2749261 1 NC_002695.1 similar to RADC family DNA repair protein YEES_ECOLI gi|1788312 (conserved in Escherichia coli K-12); DNA repair protein 2749261 914222 ECs2803 Escherichia coli O157:H7 str. Sakai DNA repair protein NP_310830.1 2748785 D 386585 CDS NP_310831.1 15832058 912759 2749324..2749545 1 NC_002695.1 similar to YEET_ECOLI gi|1788313 (conserved in Escherichia coli K-12); hypothetical protein 2749545 912759 ECs2804 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310831.1 2749324 D 386585 CDS NP_310832.1 15832059 912732 2749619..2749987 1 NC_002695.1 similar to YEEU_ECOLI gi|1788314 (conserved in Escherichia coli K-12); structural protein 2749987 912732 ECs2805 Escherichia coli O157:H7 str. Sakai structural protein NP_310832.1 2749619 D 386585 CDS NP_310833.1 15832060 912310 2750076..2750339 1 NC_002695.1 similar to YEEV_ECOLI gi|1788315; hypothetical protein 2750339 912310 ECs2806 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310833.1 2750076 D 386585 CDS NP_310834.1 15832061 913930 2750449..2750640 1 NC_002695.1 similar to YEEW_ECOLI gi|1788316 (conserved in Escherichia coli K-12); hypothetical protein 2750640 913930 ECs2807 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310834.1 2750449 D 386585 CDS NP_310835.1 15832062 912630 2751081..2751437 1 NC_002695.1 similar to PduV [Salmonella enterica serovar Typhimurium] gb|AAD39020.1; hypothetical protein 2751437 912630 ECs2808 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310835.1 2751081 D 386585 CDS NP_310836.2 38704040 912397 complement(2751538..2751867) 1 NC_002695.1 similar to YEEX_ECOLI gi|1788317 (conserved in Escherichia coli K-12); hypothetical protein 2751867 912397 ECs2809 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310836.2 2751538 R 386585 CDS NP_310837.1 15832064 912666 complement(2752039..2753097) 1 NC_002695.1 similar to YEEA_ECOLI gi|1788318 (conserved in Escherichia coli K-12); hypothetical protein 2753097 912666 ECs2810 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310837.1 2752039 R 386585 CDS NP_310838.1 15832065 914233 complement(2753296..2753769) 1 NC_002695.1 similar to SBMC_ECOLI gi|1788319 (conserved in Escherichia coli K-12); DNA gyrase inhibitor 2753769 914233 ECs2811 Escherichia coli O157:H7 str. Sakai DNA gyrase inhibitor NP_310838.1 2753296 R 386585 CDS NP_310839.1 15832066 912747 complement(2753888..2755060) 1 NC_002695.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2755060 dacD 912747 dacD Escherichia coli O157:H7 str. Sakai D-alanyl-D-alanine carboxypeptidase NP_310839.1 2753888 R 386585 CDS NP_310840.1 15832067 913411 2755263..2756690 1 NC_002695.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2756690 sbcB 913411 sbcB Escherichia coli O157:H7 str. Sakai exonuclease I NP_310840.1 2755263 D 386585 CDS NP_310841.1 15832068 913310 complement(2756733..2756960) 1 NC_002695.1 similar YEED_ECOLI to gi|1788322 (conserved in Escherichia coli K-12); hypothetical protein 2756960 913310 ECs2814 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310841.1 2756733 R 386585 CDS NP_310842.1 15832069 913376 complement(2756974..2758032) 1 NC_002695.1 similar to YEEE_ECOLI gi|1788323 (conserved in Escherichia coli K-12); transport system permease 2758032 913376 ECs2815 Escherichia coli O157:H7 str. Sakai transport system permease NP_310842.1 2756974 R 386585 CDS NP_310843.1 15832070 912852 complement(2758211..2759575) 1 NC_002695.1 similar to YEEF_ECOLI gi|1788325 (conserved in Escherichia coli K-12); amino acid/amine transport protein 2759575 912852 ECs2816 Escherichia coli O157:H7 str. Sakai amino acid/amine transport protein NP_310843.1 2758211 R 386585 CDS NP_310844.2 38704041 912696 complement(2759836..2760765) 1 NC_002695.1 similar to YEEY_ECOLI gi|1788326 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 2760765 912696 ECs2817 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_310844.2 2759836 R 386585 CDS NP_310845.1 15832072 914191 complement(2760811..2761635) 1 NC_002695.1 similar to B2016_ECOLI gi|1788327 (conserved in Escherichia coli K-12); hypothetical protein 2761635 914191 ECs2818 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310845.1 2760811 R 386585 CDS NP_310847.1 15832074 912832 2762257..2763156 1 NC_002695.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2763156 hisG 912832 hisG Escherichia coli O157:H7 str. Sakai ATP phosphoribosyltransferase NP_310847.1 2762257 D 386585 CDS NP_310848.1 15832075 912702 2763162..2764466 1 NC_002695.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2764466 hisD 912702 hisD Escherichia coli O157:H7 str. Sakai histidinol dehydrogenase NP_310848.1 2763162 D 386585 CDS NP_310849.1 15832076 914123 2764463..2765533 1 NC_002695.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2765533 914123 ECs2822 Escherichia coli O157:H7 str. Sakai histidinol-phosphate aminotransferase NP_310849.1 2764463 D 386585 CDS NP_310850.2 38704042 914091 2765533..2766600 1 NC_002695.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2766600 914091 ECs2823 Escherichia coli O157:H7 str. Sakai imidazole glycerol-phosphate dehydratase/histidinol phosphatase NP_310850.2 2765533 D 386585 CDS NP_310851.1 15832078 913853 2766600..2767190 1 NC_002695.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2767190 hisH 913853 hisH Escherichia coli O157:H7 str. Sakai imidazole glycerol phosphate synthase subunit HisH NP_310851.1 2766600 D 386585 CDS NP_310852.2 162139780 912886 2767190..2767927 1 NC_002695.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2767927 912886 ECs2825 Escherichia coli O157:H7 str. Sakai 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_310852.2 2767190 D 386585 CDS NP_310853.1 15832080 914652 2767909..2768685 1 NC_002695.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2768685 914652 ECs2826 Escherichia coli O157:H7 str. Sakai imidazole glycerol phosphate synthase subunit HisF NP_310853.1 2767909 D 386585 CDS NP_310854.1 15832081 912426 2768679..2769290 1 NC_002695.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2769290 912426 ECs2827 Escherichia coli O157:H7 str. Sakai bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase NP_310854.1 2768679 D 386585 CDS NP_310855.2 38704043 912641 complement(2769387..2770367) 1 NC_002695.1 similar to WZZB_ECOLI gi|1788339 (conserved in Escherichia coli K-12); regulator of length of O-antigen component of lipopolysaccharide chains 2770367 912641 ECs2828 Escherichia coli O157:H7 str. Sakai regulator of length of O-antigen component of lipopolysaccharide chains NP_310855.2 2769387 R 386585 CDS NP_310856.1 15832083 913058 complement(2770510..2771676) 1 NC_002695.1 similar to UGD_ECOLI gi|1788340 (conserved in Escherichia coli K-12); UDP-glucose 6-dehydrogenase 2771676 913058 ECs2829 Escherichia coli O157:H7 str. Sakai UDP-glucose 6-dehydrogenase NP_310856.1 2770510 R 386585 CDS NP_310857.1 15832084 912309 complement(2771925..2773331) 1 NC_002695.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2773331 912309 ECs2830 Escherichia coli O157:H7 str. Sakai 6-phosphogluconate dehydrogenase NP_310857.1 2771925 R 386585 CDS NP_310858.1 15832085 912352 complement(2773532..2774197) 1 NC_002695.1 similar to WbdR [Escherichia coli O157:H7 C664-1992] gi|3435182|gb|AAC32350.1|; acetyltransferase 2774197 912352 ECs2831 Escherichia coli O157:H7 str. Sakai acetyltransferase NP_310858.1 2773532 R 386585 CDS NP_310860.1 15832087 913674 complement(2774427..2774591) 1 NC_002695.1 similar to H repeat-associated proteins e.g. [Escherichia coli] gi|140772|sp|P28912|YHHI_ECOLI; H repeat-containing protein 2774591 913674 ECs2833 Escherichia coli O157:H7 str. Sakai H repeat-containing protein NP_310860.1 2774427 R 386585 CDS NP_310862.1 15832089 913941 complement(2775460..2776830) 1 NC_002695.1 similar to ManB [Escherichia coli O157:H7 C664-1992] gi|3435181|gb|AAC32349.1|; phosphomannomutase 2776830 913941 ECs2835 Escherichia coli O157:H7 str. Sakai phosphomannomutase NP_310862.1 2775460 R 386585 CDS NP_310863.1 15832090 912820 complement(2776834..2778282) 1 NC_002695.1 similar to ManC [Escherichia coli O157:H7 C664-1992] gi|3435180|gb|AAC32348.1|; mannose-1-phosphate guanylyltransferase 2778282 912820 ECs2836 Escherichia coli O157:H7 str. Sakai mannose-1-phosphate guanylyltransferase NP_310863.1 2776834 R 386585 CDS NP_310864.1 15832091 912421 complement(2778264..2778773) 1 NC_002695.1 similar to WbdQ [Escherichia coli O157:H7 C664-1992] gi|3435179|gb|AAC32347.1|; GDP-L-fucose pathway enzyme 2778773 912421 ECs2837 Escherichia coli O157:H7 str. Sakai GDP-L-fucose pathway enzyme NP_310864.1 2778264 R 386585 CDS NP_310865.1 15832092 912293 complement(2778776..2779741) 1 NC_002695.1 similar to Fcl [Escherichia coli O157:H7 C664-1992] gi|4867922|dbj|BAA77731.1|; fucose synthetase 2779741 912293 ECs2838 Escherichia coli O157:H7 str. Sakai fucose synthetase NP_310865.1 2778776 R 386585 CDS NP_310866.1 15832093 912548 complement(2779744..2780862) 1 NC_002695.1 similar to Gmd [Escherichia coli O157:H7 C664-1992]gi|3435177|gb|AAC32345.1|; GDP-D-mannose dehydratase 2780862 912548 ECs2839 Escherichia coli O157:H7 str. Sakai GDP-D-mannose dehydratase NP_310866.1 2779744 R 386585 CDS NP_944550.1 38704044 2693774 2780370..2780600 1 NC_002695.1 hypothetical protein 2780600 2693774 ECs5479 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944550.1 2780370 D 386585 CDS NP_310867.1 15832094 916916 complement(2780882..2782096) 1 NC_002695.1 similar to WbdP [Escherichia coli O157:H7 C664-1992] gi|3435176|gb|AAC32344.1|; glycosyl transferase family protein 2782096 916916 ECs2840 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310867.1 2780882 R 386585 CDS NP_310868.1 15832095 912508 complement(2782121..2783221) 1 NC_002695.1 similar to Per [Escherichia coli O157:H7 C664-1992] gi|3435175|gb|AAC32343.1|; perosamine synthetase 2783221 912508 ECs2841 Escherichia coli O157:H7 str. Sakai perosamine synthetase NP_310868.1 2782121 R 386585 CDS NP_310869.1 15832096 912601 complement(2783218..2784603) 1 NC_002695.1 similar to Wzx [Escherichia coli O157:H7 C664-1992] gi|3435174|gb|AAC32342.1|; O antigen flippase 2784603 912601 ECs2842 Escherichia coli O157:H7 str. Sakai O antigen flippase NP_310869.1 2783218 R 386585 CDS NP_310870.1 15832097 912341 complement(2784596..2785342) 1 NC_002695.1 similar to WbdO [Escherichia coli O157:H7 C664-1992] gi|3435173|gb|AAC32341.1|; glycosyl transferase family protein 2785342 912341 ECs2843 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310870.1 2784596 R 386585 CDS NP_310871.1 15832098 912486 complement(2785311..2786495) 1 NC_002695.1 similar to Wzy [Escherichia coli O157:H7 C664-1992] gi|3435172|gb|AAC32340.1|; O antigen polymerase 2786495 912486 ECs2844 Escherichia coli O157:H7 str. Sakai O antigen polymerase NP_310871.1 2785311 R 386585 CDS NP_310872.1 15832099 912412 complement(2786492..2787274) 1 NC_002695.1 similar to WbdN [Escherichia coli O157:H7 C664-1992] gi|4867915|dbj|BAA77724.1|; glycosyl transferase family protein 2787274 912412 ECs2845 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310872.1 2786492 R 386585 CDS NP_310873.1 15832100 914113 complement(2787593..2788486) 1 NC_002695.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 2788486 914113 ECs2846 Escherichia coli O157:H7 str. Sakai UTP-glucose-1-phosphate uridylyltransferase NP_310873.1 2787593 R 386585 CDS NP_310874.1 15832101 912320 complement(2788729..2789724) 1 NC_002695.1 similar to probable UDP-galactose 4-epimerase [Vibrio cholerae] gi|3724321|dbj|BAA33610.1; UDP-galactose 4-epimerase 2789724 912320 ECs2847 Escherichia coli O157:H7 str. Sakai UDP-galactose 4-epimerase NP_310874.1 2788729 R 386585 CDS NP_310875.1 15832102 912592 complement(2789882..2791276) 1 NC_002695.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein 2791276 wcaM 912592 wcaM Escherichia coli O157:H7 str. Sakai colanic acid biosynthesis protein NP_310875.1 2789882 R 386585 CDS NP_310876.1 15832103 913350 complement(2791287..2792507) 1 NC_002695.1 similar to WCAL_ECOLI gi|1788357 (conserved in Escherichia coli K-12); colanic acid biosynthesis glycosyl transferase 2792507 913350 ECs2849 Escherichia coli O157:H7 str. Sakai colanic acid biosynthesis glycosyl transferase NP_310876.1 2791287 R 386585 CDS NP_310877.1 15832104 912518 complement(2792504..2793784) 1 NC_002695.1 similar to WCAK_ECOLI gi|1788358 (conserved in Escherichia coli K-12); pyruvyl transferase 2793784 912518 ECs2850 Escherichia coli O157:H7 str. Sakai pyruvyl transferase NP_310877.1 2792504 R 386585 CDS NP_310878.1 15832105 913065 complement(2793964..2795442) 1 NC_002695.1 similar to WZXC_ECOLI gi|1788359 (conserved in Escherichia coli K-12); colanic acid exporter 2795442 913065 ECs2851 Escherichia coli O157:H7 str. Sakai colanic acid exporter NP_310878.1 2793964 R 386585 CDS NP_310879.1 15832106 912607 complement(2795444..2796838) 1 NC_002695.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase 2796838 912607 ECs2852 Escherichia coli O157:H7 str. Sakai UDP-glucose lipid carrier transferase NP_310879.1 2795444 R 386585 CDS NP_310880.1 15832107 912432 complement(2796893..2798263) 1 NC_002695.1 similar to CPSG_ECOLI gi|1788361 (conserved in Escherichia coli K-12); phosphomannomutase 2798263 912432 ECs2853 Escherichia coli O157:H7 str. Sakai phosphomannomutase NP_310880.1 2796893 R 386585 CDS NP_310881.1 15832108 912555 complement(2798456..2799892) 1 NC_002695.1 similar to CPSB_ECOLI gi|1788362 (conserved in Escherichia coli K-12); mannose-1-phosphate guanylyltransferase 2799892 912555 ECs2854 Escherichia coli O157:H7 str. Sakai mannose-1-phosphate guanylyltransferase NP_310881.1 2798456 R 386585 CDS NP_310882.1 15832109 913677 complement(2799895..2801118) 1 NC_002695.1 similar to WCAI_ECOLI gi|1788363 (conserved in Escherichia coli K-12); glycosyl transferase family protein 2801118 913677 ECs2855 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310882.1 2799895 R 386585 CDS NP_310883.1 15832110 913694 complement(2801115..2801597) 1 NC_002695.1 similar to WCAH_ECOLI gi|1788364 (conserved in Escherichia coli K-12); GDP-mannose mannosyl hydrolase 2801597 913694 ECs2856 Escherichia coli O157:H7 str. Sakai GDP-mannose mannosyl hydrolase NP_310883.1 2801115 R 386585 CDS NP_310884.1 15832111 912562 complement(2801597..2802562) 1 NC_002695.1 similar to WCAG_ECOLI pdb|1GFS_A (conserved in Escherichia coli K-12); GDP-fucose synthetase chain A 2802562 912562 ECs2857 Escherichia coli O157:H7 str. Sakai GDP-fucose synthetase chain A NP_310884.1 2801597 R 386585 CDS NP_310885.1 15832112 913961 complement(2802565..2803686) 1 NC_002695.1 similar to GMD_ECOLI gi|1788366 (conserved in Escherichia coli K-12); GDP-D-mannose dehydratase 2803686 913961 ECs2858 Escherichia coli O157:H7 str. Sakai GDP-D-mannose dehydratase NP_310885.1 2802565 R 386585 CDS NP_310886.1 15832113 912770 complement(2803715..2804263) 1 NC_002695.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2804263 912770 ECs2859 Escherichia coli O157:H7 str. Sakai colanic acid biosynthesis acetyltransferase WcaF NP_310886.1 2803715 R 386585 CDS NP_310887.1 15832114 912985 complement(2804279..2805025) 1 NC_002695.1 similar to WCAE_ECOLI gi|1788368 (conserved in Escherichia coli K-12); glycosyl transferase family protein 2805025 912985 ECs2860 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310887.1 2804279 R 386585 CDS NP_310888.1 15832115 914908 complement(2805036..2806253) 1 NC_002695.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein 2806253 wcaD 914908 wcaD Escherichia coli O157:H7 str. Sakai colanic acid biosynthesis protein NP_310888.1 2805036 R 386585 CDS NP_310889.1 15832116 912422 complement(2806228..2807445) 1 NC_002695.1 similar to WCAC_ECOLI gi|1788370 (conserved in Escherichia coli K-12); glycosyl transferase family protein 2807445 912422 ECs2862 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310889.1 2806228 R 386585 CDS NP_310890.1 15832117 912644 complement(2807442..2807930) 1 NC_002695.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2807930 912644 ECs2863 Escherichia coli O157:H7 str. Sakai colanic acid biosynthesis acetyltransferase WcaB NP_310890.1 2807442 R 386585 CDS NP_310891.1 15832118 912351 complement(2807933..2808772) 1 NC_002695.1 similar to WCAA_ECOLI gi|1788372 (conserved in Escherichia coli K-12); glycosyl transferase family protein 2808772 912351 ECs2864 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_310891.1 2807933 R 386585 CDS NP_310892.2 38704045 912525 complement(2808865..2811027) 1 NC_002695.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2811027 912525 ECs2865 Escherichia coli O157:H7 str. Sakai tyrosine kinase NP_310892.2 2808865 R 386585 CDS NP_310893.1 15832120 913690 complement(2811030..2811473) 1 NC_002695.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2811473 913690 ECs2866 Escherichia coli O157:H7 str. Sakai tyrosine phosphatase NP_310893.1 2811030 R 386585 CDS NP_310894.1 15832121 913884 complement(2811479..2812618) 1 NC_002695.1 similar to WZA_ECOLI gi|1788376 (conserved in Escherichia coli K-12); polysaccharide export protein 2812618 913884 ECs2867 Escherichia coli O157:H7 str. Sakai polysaccharide export protein NP_310894.1 2811479 R 386585 CDS NP_310895.2 38704046 914134 2813277..2814860 1 NC_002695.1 similar to YEGH_ECOLI gi|1788377 (conserved in Escherichia coli K-12); transporter 2814860 914134 ECs2868 Escherichia coli O157:H7 str. Sakai transporter NP_310895.2 2813277 D 386585 CDS NP_310896.1 15832123 912316 2814935..2815273 1 NC_002695.1 similar to hypothetical proteins e.g. gi|9106618|gb|AAF84382.1|AE003986_12 [Xylella fastidiosa]; hypothetical protein 2815273 912316 ECs2869 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310896.1 2814935 D 386585 CDS NP_310897.1 15832124 912763 2815263..2815553 1 NC_002695.1 similar to hypothetical protein [Xylella fastidiosa] gb|AAF84486.1|AE003993_5; hypothetical protein 2815553 912763 ECs2870 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310897.1 2815263 D 386585 CDS NP_310898.1 15832125 916574 complement(2815606..2817459) 1 NC_002695.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2817459 916574 ECs2871 Escherichia coli O157:H7 str. Sakai assembly protein NP_310898.1 2815606 R 386585 CDS NP_310899.1 15832126 916917 complement(2817481..2818062) 1 NC_002695.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2818062 dcd 916917 dcd Escherichia coli O157:H7 str. Sakai deoxycytidine triphosphate deaminase NP_310899.1 2817481 R 386585 CDS NP_310900.2 162139779 916575 complement(2818154..2818795) 1 NC_002695.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2818795 916575 ECs2873 Escherichia coli O157:H7 str. Sakai uridine kinase NP_310900.2 2818154 R 386585 CDS NP_310904.1 15832131 916579 complement(2822533..2823381) 1 NC_002695.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase 2823381 916579 ECs2877 Escherichia coli O157:H7 str. Sakai 3-methyladenine DNA glycosylase NP_310904.1 2822533 R 386585 CDS NP_310905.2 38704047 916580 2823515..2824867 1 NC_002695.1 similar to YEGD_ECOLI gi|1788384 (conserved in Escherichia coli K-12); chaperone 2824867 916580 ECs2878 Escherichia coli O157:H7 str. Sakai chaperone NP_310905.2 2823515 D 386585 CDS NP_310906.2 38704048 916581 complement(2824880..2826820) 1 NC_002695.1 similar to chaperonin B2070_ECOLI gi|1788385 (conserved in Escherichia coli K-12); chaperonin 2826820 916581 ECs2879 Escherichia coli O157:H7 str. Sakai chaperonin NP_310906.2 2824880 R 386585 CDS NP_310907.1 15832134 916582 complement(2826817..2827578) 1 NC_002695.1 similar to B2072_ECOLI gi|1788387 (conserved in Escherichia coli K-12); hypothetical protein 2827578 916582 ECs2880 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310907.1 2826817 R 386585 CDS NP_310908.1 15832135 916583 complement(2827575..2828234) 1 NC_002695.1 similar to B2073_ECOLI gi|1788388 (conserved in Escherichia coli K-12); hypothetical protein 2828234 916583 ECs2881 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310908.1 2827575 R 386585 CDS NP_310909.2 162139778 916584 2829450..2830697 1 NC_002695.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2830697 916584 ECs2882 Escherichia coli O157:H7 str. Sakai multidrug efflux system subunit MdtA NP_310909.2 2829450 D 386585 CDS NP_310910.1 15832137 916585 2830697..2833819 1 NC_002695.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2833819 916585 ECs2883 Escherichia coli O157:H7 str. Sakai multidrug efflux system subunit MdtB NP_310910.1 2830697 D 386585 CDS NP_310911.1 15832138 916586 2833820..2836897 1 NC_002695.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2836897 916586 ECs2884 Escherichia coli O157:H7 str. Sakai multidrug efflux system subunit MdtC NP_310911.1 2833820 D 386585 CDS NP_310912.1 15832139 916587 2836898..2838313 1 NC_002695.1 similar to YEGB_ECOLI gi|1788392 (conserved in Escherichia coli K-12); multidrug efflux system protein MdtE 2838313 916587 ECs2885 Escherichia coli O157:H7 str. Sakai multidrug efflux system protein MdtE NP_310912.1 2836898 D 386585 CDS NP_310913.1 15832140 916588 2838310..2839713 1 NC_002695.1 similar to BAES_ECOLI gi|1788393 (conserved in Escherichia coli K-12); signal transduction histidine-protein kinase BaeS 2839713 916588 ECs2886 Escherichia coli O157:H7 str. Sakai signal transduction histidine-protein kinase BaeS NP_310913.1 2838310 D 386585 CDS NP_310914.1 15832141 916589 2839710..2840432 1 NC_002695.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; BaeR family transcriptional regulator 2840432 916589 ECs2887 Escherichia coli O157:H7 str. Sakai BaeR family transcriptional regulator NP_310914.1 2839710 D 386585 CDS NP_310915.2 38704049 916590 2840623..2840955 1 NC_002695.1 similar to B2080_ECOLI gi|1788396 (conserved in Escherichia coli K-12); hypothetical protein 2840955 916590 ECs2888 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310915.2 2840623 D 386585 CDS NP_310916.1 15832143 916591 2841103..2842464 1 NC_002695.1 similar to YEGQ_ECOLI gi|1788397 (conserved in Escherichia coli K-12); hypothetical protein 2842464 916591 ECs2889 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310916.1 2841103 D 386585 CDS NP_310917.1 15832144 916592 complement(2842627..2842806) 1 NC_002695.1 similar to B2084_ECOLI gi|1788400; hypothetical protein 2842806 916592 ECs2890 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310917.1 2842627 R 386585 CDS NP_310918.1 15832145 916593 complement(2842794..2843171) 1 NC_002695.1 similar to B2085_ECOLI gi|1788401 (conserved in Escherichia coli K-12); hypothetical protein 2843171 916593 ECs2891 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310918.1 2842794 R 386585 CDS NP_310919.1 15832146 916594 2843517..2844416 1 NC_002695.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2844416 916594 ECs2892 Escherichia coli O157:H7 str. Sakai lipid kinase NP_310919.1 2843517 D 386585 CDS NP_310920.1 15832147 916595 complement(2844498..2845277) 1 NC_002695.1 similar to GATR_ECOLI sp|P36930 gi|1788403 (conserved in Escherichia coli K-12); split galactitol utilization operon repressor 2845277 916595 ECs2893 Escherichia coli O157:H7 str. Sakai split galactitol utilization operon repressor NP_310920.1 2844498 R 386585 CDS NP_310921.1 15832148 916596 complement(2845377..2846417) 1 NC_002695.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2846417 916596 ECs2894 Escherichia coli O157:H7 str. Sakai galactitol-1-phosphate dehydrogenase NP_310921.1 2845377 R 386585 CDS NP_310922.1 15832149 916597 complement(2846465..2847820) 1 NC_002695.1 similar to GATC_ECOLI gi|1788408 (conserved in Escherichia coli K-12); PTS system galactitol-specific enzyme IIC 2847820 916597 ECs2895 Escherichia coli O157:H7 str. Sakai PTS system galactitol-specific enzyme IIC NP_310922.1 2846465 R 386585 CDS NP_310923.1 15832150 916598 complement(2847824..2848108) 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2848108 916598 ECs2896 Escherichia coli O157:H7 str. Sakai PTS system galactitol-specific transporter subunit IIB NP_310923.1 2847824 R 386585 CDS NP_310924.1 15832151 916599 complement(2848139..2848591) 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 2848591 916599 ECs2897 Escherichia coli O157:H7 str. Sakai PTS system galactitol-specific transporter subunit IIA NP_310924.1 2848139 R 386585 CDS NP_310925.1 15832152 916601 complement(2848601..2849863) 1 NC_002695.1 similar to GATZ_ECOLI gi|1788411 (conserved in Escherichia coli K-12); tagatose 6-phosphate kinase 1 2849863 916601 ECs2898 Escherichia coli O157:H7 str. Sakai tagatose 6-phosphate kinase 1 NP_310925.1 2848601 R 386585 CDS NP_310926.2 162139777 916602 complement(2849892..2850746) 1 NC_002695.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2850746 gatY 916602 gatY Escherichia coli O157:H7 str. Sakai tagatose-bisphosphate aldolase NP_310926.2 2849892 R 386585 CDS NP_310927.2 38704050 916603 complement(2851045..2852097) 1 NC_002695.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2852097 916603 ECs2900 Escherichia coli O157:H7 str. Sakai fructose-bisphosphate aldolase NP_310927.2 2851045 R 386585 CDS NP_310928.1 15832155 916604 2852354..2853631 1 NC_002695.1 similar to YEGT_ECOLI gi|1788415 (conserved in Escherichia coli K-12); nucleoside permease 2853631 916604 ECs2901 Escherichia coli O157:H7 str. Sakai nucleoside permease NP_310928.1 2852354 D 386585 CDS NP_310929.1 15832156 916605 2853628..2854632 1 NC_002695.1 similar to B2099_ECOLI gi|1788416 (conserved in Escherichia coli K-12); hypothetical protein 2854632 916605 ECs2902 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310929.1 2853628 D 386585 CDS NP_310930.1 15832157 916606 2854629..2855594 1 NC_002695.1 similar to B2100_ECOLI gi|1788417 (conserved in Escherichia coli K-12); kinase 2855594 916606 ECs2903 Escherichia coli O157:H7 str. Sakai kinase NP_310930.1 2854629 D 386585 CDS NP_310931.1 15832158 916607 complement(2855568..2856314) 1 NC_002695.1 similar to YEGW_ECOLI gi|1788418 (conserved in Escherichia coli K-12); transcriptional regulator 2856314 916607 ECs2904 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_310931.1 2855568 R 386585 CDS NP_310932.1 15832159 916608 complement(2856366..2857193) 1 NC_002695.1 similar to YEGX_ECOLI gi|1788419 (conserved in Escherichia coli K-12); hypothetical protein 2857193 916608 ECs2905 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310932.1 2856366 R 386585 CDS NP_310933.1 15832160 916609 complement(2857249..2858049) 1 NC_002695.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2858049 916609 ECs2906 Escherichia coli O157:H7 str. Sakai phosphomethylpyrimidine kinase NP_310933.1 2857249 R 386585 CDS NP_310934.1 15832161 916610 complement(2858046..2858834) 1 NC_002695.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2858834 916610 ECs2907 Escherichia coli O157:H7 str. Sakai hydroxyethylthiazole kinase NP_310934.1 2858046 R 386585 CDS NP_310935.1 15832162 916611 2859168..2859407 1 NC_002695.1 hypothetical protein 2859407 916611 ECs2908 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310935.1 2859168 D 386585 CDS NP_310936.1 15832163 916612 2860458..2860805 1 NC_002695.1 hypothetical protein 2860805 916612 ECs2909 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310936.1 2860458 D 386585 CDS NP_310937.1 15832164 916613 2860815..2861129 1 NC_002695.1 outer membrane protein 2861129 916613 ECs2910 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310937.1 2860815 D 386585 CDS NP_310938.1 15832165 916614 complement(2861239..2861511) 1 NC_002695.1 similar to YOHL_ECOLI gi|1788422 (conserved in Escherichia coli K-12); hypothetical protein 2861511 916614 ECs2911 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310938.1 2861239 R 386585 CDS NP_310939.1 15832166 916615 2861632..2862471 1 NC_002695.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2862471 916615 ECs2912 Escherichia coli O157:H7 str. Sakai nickel/cobalt efflux protein RcnA NP_310939.1 2861632 D 386585 CDS NP_310940.2 38704051 916616 2862689..2863027 1 NC_002695.1 similar to B2107_ECOLI gi|1788424 (conserved in Escherichia coli K-12); hypothetical protein 2863027 916616 ECs2913 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310940.2 2862689 D 386585 CDS NP_310941.1 15832168 916617 complement(2863109..2864143) 1 NC_002695.1 similar to YEHA_ECOLI gi|1788426; type-1 fimbrial protein 2864143 916617 ECs2914 Escherichia coli O157:H7 str. Sakai type-1 fimbrial protein NP_310941.1 2863109 R 386585 CDS NP_310942.1 15832169 916618 complement(2864154..2866634) 1 NC_002695.1 similar to YEHB_ECOLI gi|1788427, ousher protein MrkC [Klebsiella pneumoniae] dad|M55912-4|AAA25095.1; outer membrane protein 2866634 916618 ECs2915 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_310942.1 2864154 R 386585 CDS NP_310943.1 15832170 916619 complement(2866650..2867324) 1 NC_002695.1 similar to YEHC_ECOLI gi|1788428, chaperone MrkB [Klebsiella pneumoniae] dad|M55912-3|AAA25094.1; chaperone 2867324 916619 ECs2916 Escherichia coli O157:H7 str. Sakai chaperone NP_310943.1 2866650 R 386585 CDS NP_310944.1 15832171 916620 complement(2867412..2867954) 1 NC_002695.1 similar to YEHD_ECOLI gi|1788429, AC/I pili protein [Escherichia coli] dad|X76121-1|CAA53727.1; fimbrial-like protein 2867954 916620 ECs2917 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_310944.1 2867412 R 386585 CDS NP_310945.1 15832172 916621 complement(2868246..2868527) 1 NC_002695.1 similar to YEHE_ECOLI gi1788430; hypothetical protein 2868527 916621 ECs2918 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310945.1 2868246 R 386585 CDS NP_310946.2 38704052 916622 complement(2868789..2869898) 1 NC_002695.1 similar to MRP_ECOLI gi|1788431 (conserved in Escherichia coli K-12); ATPase 2869898 916622 ECs2919 Escherichia coli O157:H7 str. Sakai ATPase NP_310946.2 2868789 R 386585 CDS NP_310947.1 15832174 916623 2870030..2872063 1 NC_002695.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2872063 metG 916623 metG Escherichia coli O157:H7 str. Sakai methionyl-tRNA synthetase NP_310947.1 2870030 D 386585 CDS NP_310952.1 15832179 916628 2879021..2882650 1 NC_002695.1 similar to YEHI_ECOLI gi|1788436 (conserved in Escherichia coli K-12); regulator 2882650 916628 ECs2925 Escherichia coli O157:H7 str. Sakai regulator NP_310952.1 2879021 D 386585 CDS NP_310953.1 15832180 916629 2882712..2883029 1 NC_002695.1 similar to YEHK_ECOLI gi|465578|sp|P33347 (conserved in Escherichia coli K-12); hypothetical protein 2883029 916629 ECs2926 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310953.1 2882712 D 386585 CDS NP_310954.1 15832181 916630 2884204..2885358 1 NC_002695.1 similar to YEHL_ECOLI gi|1788438 (conserved in Escherichia coli K-12); hypothetical protein 2885358 916630 ECs2927 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310954.1 2884204 D 386585 CDS NP_310957.1 15832184 916633 2887641..2888777 1 NC_002695.1 similar to YEHP_ECOLI gi|1788440 (conserved in Escherichia coli K-12); hypothetical protein 2888777 916633 ECs2930 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310957.1 2887641 D 386585 CDS NP_310958.1 15832185 916634 2888774..2891011 1 NC_002695.1 similar to YEHQ_ECOLI gi|1788441; hypothetical protein 2891011 916634 ECs2931 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310958.1 2888774 D 386585 CDS NP_310959.1 15832186 916635 complement(2890818..2891708) 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 2891708 916635 ECs2932 Escherichia coli O157:H7 str. Sakai transposase NP_310959.1 2890818 R 386585 CDS NP_310960.1 15832187 916636 complement(2891705..2892031) 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase 2892031 916636 ECs2933 Escherichia coli O157:H7 str. Sakai transposase NP_310960.1 2891705 R 386585 CDS NP_310961.1 15832188 916637 2892203..2892676 1 NC_002695.1 similar to YEHR_ECOLI gi|1788442 (conserved in Escherichia coli K-12); hypothetical protein 2892676 916637 ECs2934 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310961.1 2892203 D 386585 CDS NP_310962.1 15832189 916638 complement(2892718..2893188) 1 NC_002695.1 similar to YEHS_ECOLI gi|1788443 (conserved in Escherichia coli K-12); hypothetical protein 2893188 916638 ECs2935 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310962.1 2892718 R 386585 CDS NP_310963.2 38704053 916639 complement(2893235..2893954) 1 NC_002695.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2893954 916639 ECs2936 Escherichia coli O157:H7 str. Sakai two-component response-regulatory protein YehT NP_310963.2 2893235 R 386585 CDS NP_310964.1 15832191 916640 complement(2893951..2895636) 1 NC_002695.1 similar to YEHU_ECOLI gi|1788446 (conserved in Escherichia coli K-12); 2-component sensor protein 2895636 916640 ECs2937 Escherichia coli O157:H7 str. Sakai 2-component sensor protein NP_310964.1 2893951 R 386585 CDS NP_310966.1 15832193 916642 2896151..2896399 1 NC_002695.1 hypothetical protein 2896399 916642 ECs2939 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310966.1 2896151 D 386585 CDS NP_310967.1 15832194 916643 complement(2896767..2897075) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 2897075 916643 ECs2940 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310967.1 2896767 R 386585 CDS NP_310968.1 15832195 916644 complement(2897038..2898351) 1 NC_002695.1 similar to tail fiber proteins e.g. [Bacteriophage 933W] gi|4585436|gb|AAD25464.1|AF125520_59; tail fiber protein 2898351 916644 ECs2941 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_310968.1 2897038 R 386585 CDS NP_310969.1 15832196 916645 complement(2898416..2899015) 1 NC_002695.1 similar to Lom precursors e.g. [Bacteriophage P-EibA] gi|7532789|gb|AAF63231.1|AF151091_2; outer membrane protein Lom 2899015 916645 ECs2942 Escherichia coli O157:H7 str. Sakai outer membrane protein Lom NP_310969.1 2898416 R 386585 CDS NP_310972.1 15832199 916648 complement(2902796..2903473) 1 NC_002695.1 similar to tail assembly proteins e.g. GpI [Bacteriophage lambda] gi|139637|sp|P03730|VTAI_LAMBD; tail assembly protein 2903473 916648 ECs2945 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310972.1 2902796 R 386585 CDS NP_310973.1 15832200 916649 complement(2903371..2904114) 1 NC_002695.1 similar to tail assembly proteins e.g. GpK [Bacteriophage lambda] gi|139638|sp|P03729|VTAK_LAMBD; tail assembly protein 2904114 916649 ECs2946 Escherichia coli O157:H7 str. Sakai tail assembly protein NP_310973.1 2903371 R 386585 CDS NP_310974.1 15832201 916650 complement(2904125..2904823) 1 NC_002695.1 similar to minor tail proteins e.g. GpI[Bacteriophage lambda] gi|138844|sp|P03738|VMTL_LAMBD; minor tail protein 2904823 916650 ECs2947 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310974.1 2904125 R 386585 CDS NP_310975.1 15832202 916651 complement(2904823..2905152) 1 NC_002695.1 similar to minor tail proteins e.g. GpM [Bacteriophage lambda] gi|138845|sp|P03737|VMTM_LAMBD; minor tail protein 2905152 916651 ECs2948 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310975.1 2904823 R 386585 CDS NP_310976.1 15832203 916652 complement(2905149..2907794) 1 NC_002695.1 similar to tail length tape measure protein precursors e.g. GpH [Bacteriophage lambda] gi|138843|sp|P03736|VMTH_LAMBD; tail length tape measure protein 2907794 916652 ECs2949 Escherichia coli O157:H7 str. Sakai tail length tape measure protein NP_310976.1 2905149 R 386585 CDS NP_310977.1 15832204 916653 complement(2907838..2908146) 1 NC_002695.1 similar to minor tail proteins e.g. GpT [Bacteriophage lambda] gi|138846|sp|P03735|VMTT_LAMBD; may be produced by translational frameshift; minor tail protein 2908146 916653 ECs2950 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310977.1 2907838 R 386585 CDS NP_310978.1 15832205 916654 complement(2908173..2908595) 1 NC_002695.1 similar to minor tail proteins e.g. GpG [Bacteriophage lambda] gi|138842|sp|P03734|VMTG_LAMBD; minor tail protein 2908595 916654 ECs2951 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310978.1 2908173 R 386585 CDS NP_310979.1 15832206 916655 complement(2908609..2909361) 1 NC_002695.1 hypothetical protein 2909361 916655 ECs2952 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310979.1 2908609 R 386585 CDS NP_310980.1 15832207 916656 complement(2909369..2909767) 1 NC_002695.1 similar to minor tail proteins e.g. GpU [Bacteriophage lambda] gi|138847|sp|P03732|VMTU_LAMBD; minor tail protein U 2909767 916656 ECs2953 Escherichia coli O157:H7 str. Sakai minor tail protein U NP_310980.1 2909369 R 386585 CDS NP_310981.1 15832208 916657 complement(2909780..2910403) 1 NC_002695.1 similar to minor tail proteins e.g. GpZ [Bacteriophage lambda] gi|138849|sp|P03731|VMTZ_LAMBD; minor tail protein 2910403 916657 ECs2954 Escherichia coli O157:H7 str. Sakai minor tail protein NP_310981.1 2909780 R 386585 CDS NP_310982.1 15832209 916658 complement(2910406..2910687) 1 NC_002695.1 hypothetical protein 2910687 916658 ECs2955 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310982.1 2910406 R 386585 CDS NP_310983.1 15832210 916660 complement(2910680..2911006) 1 NC_002695.1 hypothetical protein 2911006 916660 ECs2956 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310983.1 2910680 R 386585 CDS NP_310984.1 15832211 916661 complement(2911094..2912110) 1 NC_002695.1 hypothetical protein 2912110 916661 ECs2957 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310984.1 2911094 R 386585 CDS NP_310985.1 15832212 916662 2912256..2912582 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241; transposase 2912582 916662 ECs2958 Escherichia coli O157:H7 str. Sakai transposase NP_310985.1 2912256 D 386585 CDS NP_310986.1 15832213 916663 2912579..2913469 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 2913469 916663 ECs2959 Escherichia coli O157:H7 str. Sakai transposase NP_310986.1 2912579 D 386585 CDS NP_310987.1 15832214 916664 complement(2913472..2914578) 1 NC_002695.1 similar to scaffolding protein [Streptococcus thermophilus bacteriophage DT1] gi|4530143|gb|AAD21883.1, protease/scaffold protein, ClpP proteases e.g. [Bacteriophage D3] gi|5059251|gb|AAD38956.1; protease/scaffold protein 2914578 916664 ECs2960 Escherichia coli O157:H7 str. Sakai protease/scaffold protein NP_310987.1 2913472 R 386585 CDS NP_310988.1 15832215 916665 complement(2914376..2915878) 1 NC_002695.1 similar to portal protein-like protein [Wolbachia sp. wKue] gi|6723246|dbj|BAA89642.1, portal proteins e.g. gp4 [phage 21] gi|549295|sp|P36272|VG04_BPP21; portal protein 2915878 916665 ECs2961 Escherichia coli O157:H7 str. Sakai portal protein NP_310988.1 2914376 R 386585 CDS NP_310989.1 15832216 916666 complement(2915878..2916114) 1 NC_002695.1 hypothetical protein 2916114 916666 ECs2962 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310989.1 2915878 R 386585 CDS NP_310990.1 15832217 916667 complement(2916087..2918210) 1 NC_002695.1 similar to terminase large subunit-like protein [Wolbachia sp. wKue] gi|6723244|dbj|BAA89640.1, terminase large subunits e.g. GpA [Bacteriophage lambda] gi|137616|sp|P0370; terminase large subunit 2918210 916667 ECs2963 Escherichia coli O157:H7 str. Sakai terminase large subunit NP_310990.1 2916087 R 386585 CDS NP_310991.1 15832218 916668 complement(2918207..2918683) 1 NC_002695.1 hypothetical protein 2918683 916668 ECs2964 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310991.1 2918207 R 386585 CDS NP_944551.1 38704054 2693765 2918740..2918988 1 NC_002695.1 hypothetical protein 2918988 2693765 ECs5480 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944551.1 2918740 D 386585 CDS NP_310992.1 15832219 916669 complement(2919138..2919605) 1 NC_002695.1 host cell lysis; similar to Rz [Bacteriophage VT2-Sa] gi|5881639|dbj|BAA84330.1|, similar to endopeptidases e.g. Rz [Bacteriophage lambda] gi|119368|sp|P00726|ENPP_LAMBD; endopeptidase 2919605 916669 ECs2966 Escherichia coli O157:H7 str. Sakai endopeptidase NP_310992.1 2919138 R 386585 CDS NP_310994.1 15832221 916671 complement(2919759..2920328) 1 NC_002695.1 similar to antirepressor protein [Bacteriophage 933W] gi|4585423|gb|AAD25451.1|AF125520_46, antirepressor protein Ant [Bacteriophage P22]; antirepressor protein 2920328 916671 ECs2967 Escherichia coli O157:H7 str. Sakai antirepressor protein NP_310994.1 2919759 R 386585 CDS NP_310995.1 15832222 916672 complement(2920599..2921132) 1 NC_002695.1 similar to endolysin [Bacteriophage 933W] gi|4585422|gb|AAD25450.1|AF125520_45, similar to endolysins e.g. R protein [Bacteriophage H-19B] gi|4335686|gb|AAD17382.1; endolysin 2921132 916672 ECs2968 Escherichia coli O157:H7 str. Sakai endolysin NP_310995.1 2920599 R 386585 CDS NP_310996.1 15832223 916673 complement(2921137..2921352) 1 NC_002695.1 similar to holin [Bacteriophage 933W] gi|4499808|emb|CAB39307.1|, similar to holins e.g. protein S [Bacteriophage 21] gi|138706|sp|P27360|VLYS_BPP21; holin 2921352 916673 ECs2969 Escherichia coli O157:H7 str. Sakai holin NP_310996.1 2921137 R 386585 CDS NP_310997.1 15832224 916674 complement(2921430..2921675) 1 NC_002695.1 similar to hypothetical protein [Shigella dysenteriae] gi|6759966|gb|AAF28124.1|AF153317_20; hypothetical protein 2921675 916674 ECs2970 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310997.1 2921430 R 386585 CDS NP_310998.1 15832225 916675 complement(2921716..2921895) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4499806|emb|CAB39305.1|; hypothetical protein 2921895 916675 ECs2971 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310998.1 2921716 R 386585 CDS NP_310999.1 15832226 916676 complement(2922033..2923979) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881634|dbj|BAA84325.1|; hypothetical protein 2923979 916676 ECs2972 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_310999.1 2922033 R 386585 CDS NP_311000.1 15832227 916677 complement(2924490..2924759) 1 NC_002695.1 similar to Shiga toxin I subunit B precursor gi|134539|sp|P08027|SLTB_BPH30; Shiga toxin I subunit B 2924759 916677 ECs2973 Escherichia coli O157:H7 str. Sakai Shiga toxin I subunit B NP_311000.1 2924490 R 386585 CDS NP_311001.1 15832228 916678 complement(2924769..2925716) 1 NC_002695.1 similar to Shiga toxin I subunit A precursor [Shigella dysenteriae] gi|134537|sp|P10149|SLTA_BPH30; Shiga toxin I subunit A 2925716 916678 ECs2974 Escherichia coli O157:H7 str. Sakai Shiga toxin I subunit A NP_311001.1 2924769 R 386585 CDS NP_311002.1 15832229 916679 complement(2926223..2926657) 1 NC_002695.1 similar to antitermination proteins e.g. protein Q [Bacteriophage H-19B]; antitermination protein 2926657 916679 ECs2975 Escherichia coli O157:H7 str. Sakai antitermination protein NP_311002.1 2926223 R 386585 CDS NP_311003.1 15832230 916680 complement(2926650..2926844) 1 NC_002695.1 similar to hypothetical proteins e.g. Nin 68 [Bacteriophage lambda] gi|1351593|sp|P03771|Y68_LAMBD; hypothetical protein 2926844 916680 ECs2976 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311003.1 2926650 R 386585 CDS NP_311004.1 15832231 916681 complement(2926841..2927446) 1 NC_002695.1 similar to hypothetical proteins e.g. NinG protein [Bacteriophage 21] gi|4539482|emb|CAB39991.1|; hypothetical protein 2927446 916681 ECs2977 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311004.1 2926841 R 386585 CDS NP_311005.1 15832232 916682 complement(2927439..2927648) 1 NC_002695.1 similar to hypothetical proteins e.g., NinF [Bacteriophage P22] gi|512350|emb|CAA55162.1|; hypothetical protein 2927648 916682 ECs2978 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311005.1 2927439 R 386585 CDS NP_311006.1 15832233 916683 complement(2927608..2928009) 1 NC_002695.1 hypothetical protein 2928009 916683 ECs2979 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311006.1 2927608 R 386585 CDS NP_311007.1 15832234 916684 complement(2928012..2928188) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881625|dbj|BAA84316.1|, Nin E proteins e.g. [Bacteriophage 21]; protein NinE 2928188 916684 ECs2980 Escherichia coli O157:H7 str. Sakai protein NinE NP_311007.1 2928012 R 386585 CDS NP_311008.1 15832235 916685 complement(2928185..2928712) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage VT2-Sa] gi|5881624|dbj|BAA84315.1|, DNA N-6-adenine-methyltransferase [Bacteriophage T1]; DNA methylase 2928712 916685 ECs2981 Escherichia coli O157:H7 str. Sakai DNA methylase NP_311008.1 2928185 R 386585 CDS NP_311009.1 15832236 916686 complement(2928709..2929155) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585410|gb|AAD25438.1|AF125520_33, NinB [Bacteriophage 21] gi|4539479|emb|CAB39988.1|; hypothetical protein 2929155 916686 ECs2982 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311009.1 2928709 R 386585 CDS NP_311010.1 15832237 916687 complement(2929112..2929537) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585409|gb|AAD25437.1|AF125520_32; hypothetical protein 2929537 916687 ECs2983 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311010.1 2929112 R 386585 CDS NP_311011.1 15832238 916688 complement(2929707..2929985) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4499788|emb|CAB39287.1|; hypothetical protein 2929985 916688 ECs2984 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311011.1 2929707 R 386585 CDS NP_311012.1 15832239 916689 complement(2930056..2930346) 1 NC_002695.1 similar to Ren proteins e.g. [Bacteriophage lambda] gi|139473|sp|P03761|VREN_LAMBD; Ren protein 2930346 916689 ECs2985 Escherichia coli O157:H7 str. Sakai Ren protein NP_311012.1 2930056 R 386585 CDS NP_311013.1 15832240 916690 complement(2930343..2931044) 1 NC_002695.1 similar to phage replication protein P e.g. [Bacteriophage lambda] gi|139488|sp|P03689|VRPP_LAMBD; phage replication protein P 2931044 916690 ECs2986 Escherichia coli O157:H7 str. Sakai phage replication protein P NP_311013.1 2930343 R 386585 CDS NP_311014.1 15832241 916691 complement(2931041..2931979) 1 NC_002695.1 similar to phage replication protein O e.g. [Bacteriophage 933W] gi|4585405|gb|AAD25433.1|AF125520_28; phage replication protein O 2931979 916691 ECs2987 Escherichia coli O157:H7 str. Sakai phage replication protein O NP_311014.1 2931041 R 386585 CDS NP_311015.1 15832242 916692 complement(2932012..2932308) 1 NC_002695.1 similar to regulatory protein CII e.g. [Bacteriophage 933W] gi|4585404|gb|AAD25432.1|AF125520_27; regulatory protein CII 2932308 916692 ECs2988 Escherichia coli O157:H7 str. Sakai regulatory protein CII NP_311015.1 2932012 R 386585 CDS NP_311016.1 15832243 916693 complement(2932423..2932641) 1 NC_002695.1 similar to probable regulatory proteins e.g. [Bacteriophage VT2-Sa] gi|5881616|dbj|BAA84307.1|; regulatory protein 2932641 916693 ECs2989 Escherichia coli O157:H7 str. Sakai regulatory protein NP_311016.1 2932423 R 386585 CDS NP_311017.1 15832244 916694 2932759..2933397 1 NC_002695.1 similar to prophage repressor CI e.g. [Bacteriophage lambda] gi|133353|sp|P03034|RPC1_LAMBD; prophage repressor CI 2933397 916694 ECs2990 Escherichia coli O157:H7 str. Sakai prophage repressor CI NP_311017.1 2932759 D 386585 CDS NP_311018.1 15832245 916695 2933520..2933801 1 NC_002695.1 hypothetical protein 2933801 916695 ECs2991 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311018.1 2933520 D 386585 CDS NP_311019.1 15832246 916696 2933808..2934359 1 NC_002695.1 hypothetical protein 2934359 916696 ECs2992 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311019.1 2933808 D 386585 CDS NP_311021.1 15832248 916698 2934872..2935144 1 NC_002695.1 transcription anti-termination; similar to transcription anti-termination proteins e.g. protein N [Bacteriophage phi-21] gi|132274|sp|P07243|REGN_BPPH3; regulatory protein 2935144 916698 ECs2993 Escherichia coli O157:H7 str. Sakai regulatory protein NP_311021.1 2934872 D 386585 CDS NP_311022.1 15832249 916699 complement(2935161..2935742) 1 NC_002695.1 similar to superinfection exclusion protein B [Bacteriophage P22] gi|585991|sp|P38396|SIEB_BPP22; superinfection exclusion protein 2935742 916699 ECs2995 Escherichia coli O157:H7 str. Sakai superinfection exclusion protein NP_311022.1 2935161 R 386585 CDS NP_311023.1 15832250 916700 2936003..2936371 1 NC_002695.1 similar to single-stranded DNA binding protein [Bacteriophage 933W], Ea10 (single-stranded DNA binding protein) [Bacteriophage lambda] gi|137630|sp|P03757|VE10_LAMBD; single-stranded DNA binding protein 2936371 916700 ECs2996 Escherichia coli O157:H7 str. Sakai single-stranded DNA binding protein NP_311023.1 2936003 D 386585 CDS NP_311024.1 15832251 916701 2936444..2936608 1 NC_002695.1 antitermination; similar to regulatory proteins cIII [Bacteriophage lambda] gi|133366|sp|P03044|RPC3_LAMBD; regulatory protein cIII 2936608 916701 ECs2997 Escherichia coli O157:H7 str. Sakai regulatory protein cIII NP_311024.1 2936444 D 386585 CDS NP_311025.1 15832252 916702 2936451..2936720 1 NC_002695.1 host killing; similar to Kil proteins e.g. [Bacteriophage lambda] gi|138622|sp|P03758|VKIL_LAMBD; Kil protein 2936720 916702 ECs2998 Escherichia coli O157:H7 str. Sakai Kil protein NP_311025.1 2936451 D 386585 CDS NP_311028.1 15832255 916705 2937098..2937883 1 NC_002695.1 recombination protein; similar to Bet protein [Bacteriophage 933W] gi|4585391|gb|AAD25419.1|AF125520_14, Bet protein [Bacteriophage lambda] gi|137511|sp|P03698|VBET_LAMBD; hypothetical protein 2937883 916705 ECs3001 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311028.1 2937098 D 386585 CDS NP_311029.1 15832256 916706 2937880..2938557 1 NC_002695.1 similar to exonucleases [Bacteriophage 933W] gi|4585390|gb|AAD25418.1|AF125520_13, exonucleases e.g. [Bacteriophage lambda] gi|119702|sp|P03697|EXO_LAMBD; exonuclease 2938557 916706 ECs3002 Escherichia coli O157:H7 str. Sakai exonuclease NP_311029.1 2937880 D 386585 CDS NP_311030.1 15832257 916707 2938551..2938739 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585389|gb|AAD25417.1|AF125520_12, hypothetical protein orf60a [Bacteriophage lambda] gi|508995|gb|AAA96568.1|; hypothetical protein 2938739 916707 ECs3003 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311030.1 2938551 D 386585 CDS NP_311031.1 15832258 916708 2938712..2938903 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585388|gb|AAD25416.1|AF125520_11, orf63 [Bacteriophage lambda] gi|508994|gb|AAA96567.1|; hypothetical protein 2938903 916708 ECs3004 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311031.1 2938712 D 386585 CDS NP_311032.1 15832259 916709 2938914..2939195 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585387|gb|AAD25415.1|AF125520_10, hypothetical protein orf61 [Bacteriophage lambda]; hypothetical protein 2939195 916709 ECs3005 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311032.1 2938914 D 386585 CDS NP_311033.1 15832260 916710 2939294..2939515 1 NC_002695.1 similar to C4-type zinc finger proteins (TraR family) e.g. gi|7649830|dbj|BAA94108.1; C4-type zinc finger protein 2939515 916710 ECs3006 Escherichia coli O157:H7 str. Sakai C4-type zinc finger protein NP_311033.1 2939294 D 386585 CDS NP_311034.1 15832261 916711 2939512..2940459 1 NC_002695.1 similar to hypothetical protein Bacteriophage 933W AAD25483, hypothetical protein Bacteriophage HK022 AAF30379; hypothetical protein 2940459 916711 ECs3007 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311034.1 2939512 D 386585 CDS NP_944552.1 38704055 2693766 2940687..2940974 1 NC_002695.1 hypothetical protein 2940974 2693766 ECs5481 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944552.1 2940687 D 386585 CDS NP_311036.1 15832263 916713 2940971..2941327 1 NC_002695.1 similar to hypothetical protein Bacteriophage 933W AAD25410; hypothetical protein 2941327 916713 ECs3009 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311036.1 2940971 D 386585 CDS NP_311037.1 15832264 916714 2941324..2941686 1 NC_002695.1 similar to hypothetical proteins e.g. [Bacteriophage 933W] gi|4585455|gb|AAD25483.1|AF125520_78; hypothetical protein 2941686 916714 ECs3010 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311037.1 2941324 D 386585 CDS NP_311038.1 15832265 916715 2941774..2942016 1 NC_002695.1 hypothetical protein 2942016 916715 ECs3011 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311038.1 2941774 D 386585 CDS NP_944553.1 38704056 2693767 2942020..2942154 1 NC_002695.1 hypothetical protein 2942154 2693767 ECs5482 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944553.1 2942020 D 386585 CDS NP_311039.1 15832266 916716 2942173..2942427 1 NC_002695.1 similar to excisionases e.g. [Bacteriophage 933W] gi|4585379|gb|AAD25407.1|AF125520_2; excisionase 2942427 916716 ECs3012 Escherichia coli O157:H7 str. Sakai excisionase NP_311039.1 2942173 D 386585 CDS NP_311040.1 15832267 916717 2942461..2943747 1 NC_002695.1 similar to integrases e.g. [Bacteriophage 933W] gi|4585378|gb|AAD25406.1|AF125520_1; integrase 2943747 916717 ECs3013 Escherichia coli O157:H7 str. Sakai integrase NP_311040.1 2942461 D 386585 CDS NP_311041.1 15832268 916718 2943822..2944469 1 NC_002695.1 similar to YEHV_ECOLI gi|1788448 (conserved in Escherichia coli K-12); transcriptional regulator 2944469 916718 ECs3014 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311041.1 2943822 D 386585 CDS NP_311042.1 15832269 916719 complement(2944617..2945348) 1 NC_002695.1 similar to YEHW_ECOLI gi|1788449 (conserved in Escherichia coli K-12); transport system permease 2945348 916719 ECs3015 Escherichia coli O157:H7 str. Sakai transport system permease NP_311042.1 2944617 R 386585 CDS NP_311043.1 15832270 916720 complement(2945353..2946279) 1 NC_002695.1 similar to YEHX_ECOLI gi|1788450 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 2946279 916720 ECs3016 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311043.1 2945353 R 386585 CDS NP_311044.1 15832271 916721 complement(2946272..2947429) 1 NC_002695.1 similar to YEHY_ECOLI gi|1788451 (conserved in Escherichia coli K-12); transport system permease 2947429 916721 ECs3017 Escherichia coli O157:H7 str. Sakai transport system permease NP_311044.1 2946272 R 386585 CDS NP_311045.1 15832272 916722 complement(2947436..2948353) 1 NC_002695.1 similar to YEHZ_ECOLI gi|1788452 (conserved in Escherichia coli K-12); transport system permease 2948353 916722 ECs3018 Escherichia coli O157:H7 str. Sakai transport system permease NP_311045.1 2947436 R 386585 CDS NP_311046.1 15832273 916723 complement(2948605..2950902) 1 NC_002695.1 similar to BGLX_ECOLI gi|1788453 (conserved in Escherichia coli K-12); beta-D-glucoside glucohydrolase 2950902 916723 ECs3019 Escherichia coli O157:H7 str. Sakai beta-D-glucoside glucohydrolase NP_311046.1 2948605 R 386585 CDS NP_311047.1 15832274 916724 2951098..2952813 1 NC_002695.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2952813 916724 ECs3020 Escherichia coli O157:H7 str. Sakai D-lactate dehydrogenase NP_311047.1 2951098 D 386585 CDS NP_311048.1 15832275 916725 complement(2952851..2953792) 1 NC_002695.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2953792 pbpG 916725 pbpG Escherichia coli O157:H7 str. Sakai D-alanyl-D-alanine endopeptidase NP_311048.1 2952851 R 386585 CDS NP_311049.1 15832276 916726 complement(2953957..2954568) 1 NC_002695.1 similar to YOHC_ECOLI gi|1788457 (conserved in Escherichia coli K-12); hypothetical protein 2954568 916726 ECs3022 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311049.1 2953957 R 386585 CDS NP_311050.1 15832277 916727 2954678..2955292 1 NC_002695.1 similar to YOHD_ECOLI gi|1788458 (conserved in Escherichia coli K-12); hypothetical protein 2955292 916727 ECs3023 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311050.1 2954678 D 386585 CDS NP_311051.1 15832278 916728 complement(2955422..2956183) 1 NC_002695.1 similar to YOHF_ECOLI gi|1788459 (conserved in Escherichia coli K-12); acetoin dehydrogenase 2956183 916728 ECs3024 Escherichia coli O157:H7 str. Sakai acetoin dehydrogenase NP_311051.1 2955422 R 386585 CDS NP_311052.2 38704057 916729 complement(2956236..2957672) 1 NC_002695.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2957672 916729 ECs3025 Escherichia coli O157:H7 str. Sakai multidrug resistance outer membrane protein MdtQ NP_311052.2 2956236 R 386585 CDS NP_311053.1 15832280 916730 complement(2958367..2959317) 1 NC_002695.1 similar to YOHI_ECOLI gi|1788462 (conserved in Escherichia coli K-12); tRNA-dihydrouridine synthase C 2959317 916730 ECs3026 Escherichia coli O157:H7 str. Sakai tRNA-dihydrouridine synthase C NP_311053.1 2958367 R 386585 CDS NP_311054.1 15832281 916731 complement(2959477..2960670) 1 NC_002695.1 catalyzes the formation of catechol from salicylate; salicylate hydroxylase 2960670 916731 ECs3027 Escherichia coli O157:H7 str. Sakai salicylate hydroxylase NP_311054.1 2959477 R 386585 CDS NP_311055.1 15832282 916732 complement(2960685..2961332) 1 NC_002695.1 similar to glutathione-S-transferases e.g. [Pseudomonas sp. U2] gi|3406829|gb|AAC29501.1|; glutathione-S-transferase 2961332 916732 ECs3028 Escherichia coli O157:H7 str. Sakai glutathione-S-transferase NP_311055.1 2960685 R 386585 CDS NP_311056.1 15832283 916733 complement(2961338..2962039) 1 NC_002695.1 similar to isomerase e.g. isomerase-decarboxylase homolog [Pseudomonas sp. U2] gi|3406828|gb|AAC29500.1, hypothetical protein Orf2 [Sphingomonas sp. RW5] gi|3550668|emb|CAA12268.1|; isomerase 2962039 916733 ECs3029 Escherichia coli O157:H7 str. Sakai isomerase NP_311056.1 2961338 R 386585 CDS NP_311057.1 15832284 916734 complement(2962054..2963082) 1 NC_002695.1 similar to gentisate 1,2-dioxygenases e.g. [Pseudomonas alcaligenes] gi|5733104|gb|AAD49427.1|AF173167_1, [Sphingomonas sp. RW5] gi|3550667|emb|CAA12267.1|; gentisate 1,2-dioxygenase 2963082 916734 ECs3030 Escherichia coli O157:H7 str. Sakai gentisate 1,2-dioxygenase NP_311057.1 2962054 R 386585 CDS NP_311058.1 15832285 916735 complement(2963094..2964452) 1 NC_002695.1 similar to transport proteins e.g. 4-hydroxybenzoate transporter [Pseudomonas putida] gi|6093655|sp|Q51955|PCAK_PSEPU; transporter 2964452 916735 ECs3031 Escherichia coli O157:H7 str. Sakai transporter NP_311058.1 2963094 R 386585 CDS NP_311059.2 38704058 916736 2964579..2965487 1 NC_002695.1 similar to regulatory proteins e.g. galactose binding protein regulator [Azospirillum brasilense] gi|1730232|sp|P52661|GBPR_AZOBR; regulatory protein 2965487 916736 ECs3032 Escherichia coli O157:H7 str. Sakai regulatory protein NP_311059.2 2964579 D 386585 CDS NP_311060.1 15832287 916737 2965618..2966016 1 NC_002695.1 similar to YOHJ_ECOLI gi|1788463 (conserved in Escherichia coli K-12); hypothetical protein 2966016 916737 ECs3033 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311060.1 2965618 D 386585 CDS NP_311061.1 15832288 916738 2966013..2966708 1 NC_002695.1 similar to YOHK_ECOLI gi|1788464 (conserved in Escherichia coli K-12); hypothetical protein 2966708 916738 ECs3034 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311061.1 2966013 D 386585 CDS NP_311062.1 15832289 916739 2966838..2967722 1 NC_002695.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2967722 916739 ECs3035 Escherichia coli O157:H7 str. Sakai cytidine deaminase NP_311062.1 2966838 D 386585 CDS NP_311063.1 15832290 916740 2967872..2968591 1 NC_002695.1 similar to SANA_ECOLI gi|1788466 (conserved in Escherichia coli K-12); hypothetical protein 2968591 916740 ECs3036 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311063.1 2967872 D 386585 CDS NP_311064.1 15832291 916741 2968594..2968833 1 NC_002695.1 similar to B2145_ECOLI gi|1788467 (conserved in Escherichia coli K-12); hypothetical protein 2968833 916741 ECs3037 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311064.1 2968594 D 386585 CDS NP_311065.1 15832292 916742 2969027..2970265 1 NC_002695.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2970265 916742 ECs3038 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311065.1 2969027 D 386585 CDS NP_311066.2 162139776 916743 2970259..2971494 1 NC_002695.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2971494 916743 ECs3039 Escherichia coli O157:H7 str. Sakai dihydropyrimidine dehydrogenase NP_311066.2 2970259 D 386585 CDS NP_311067.1 15832294 916744 complement(2971737..2972747) 1 NC_002695.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 2972747 mglC 916744 mglC Escherichia coli O157:H7 str. Sakai beta-methylgalactoside transporter inner membrane protein NP_311067.1 2971737 R 386585 CDS NP_311068.1 15832295 916745 complement(2972763..2974283) 1 NC_002695.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2974283 916745 ECs3041 Escherichia coli O157:H7 str. Sakai galactose/methyl galaxtoside transporter ATP-binding protein NP_311068.1 2972763 R 386585 CDS NP_311069.1 15832296 916746 complement(2974344..2975342) 1 NC_002695.1 similar to MGLB_ECOLI gi|1788473 (conserved in Escherichia coli K-12); galactose-binding transport protein 2975342 916746 ECs3042 Escherichia coli O157:H7 str. Sakai galactose-binding transport protein NP_311069.1 2974344 R 386585 CDS NP_311070.1 15832297 916747 complement(2975621..2976661) 1 NC_002695.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2976661 916747 ECs3043 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator GalS NP_311070.1 2975621 R 386585 CDS NP_311071.1 15832298 916748 complement(2976803..2977960) 1 NC_002695.1 similar to YEIB_ECOLI gi|1788475 (conserved in Escherichia coli K-12); hypothetical protein 2977960 916748 ECs3044 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311071.1 2976803 R 386585 CDS NP_311072.1 15832299 916749 complement(2977977..2978645) 1 NC_002695.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2978645 folE 916749 folE Escherichia coli O157:H7 str. Sakai GTP cyclohydrolase I NP_311072.1 2977977 R 386585 CDS NP_311073.1 15832300 916750 2978903..2979739 1 NC_002695.1 similar to YEIG_ECOLI gi|1788477 (conserved in Escherichia coli K-12); esterase 2979739 916750 ECs3046 Escherichia coli O157:H7 str. Sakai esterase NP_311073.1 2978903 D 386585 CDS NP_311074.1 15832301 916751 complement(2979771..2981750) 1 NC_002695.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2981750 916751 ECs3047 Escherichia coli O157:H7 str. Sakai colicin I receptor NP_311074.1 2979771 R 386585 CDS NP_311075.1 15832302 916752 complement(2982042..2983511) 1 NC_002695.1 similar to LYSP_ECOLI gi|1788480 (conserved in Escherichia coli K-12); lysine transporter 2983511 916752 ECs3048 Escherichia coli O157:H7 str. Sakai lysine transporter NP_311075.1 2982042 R 386585 CDS NP_311076.1 15832303 916753 complement(2983716..2984597) 1 NC_002695.1 similar to YEIE_ECOLI gi|1788481 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 2984597 916753 ECs3049 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_311076.1 2983716 R 386585 CDS NP_311077.1 15832304 916754 2984696..2985745 1 NC_002695.1 similar to YEIH_ECOLI gi|1788482 (conserved in Escherichia coli K-12); hypothetical protein 2985745 916754 ECs3050 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311077.1 2984696 D 386585 CDS NP_311078.1 15832305 916755 2985819..2986676 1 NC_002695.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2986676 916755 ECs3051 Escherichia coli O157:H7 str. Sakai endonuclease IV NP_311078.1 2985819 D 386585 CDS NP_311079.1 15832306 916756 2986679..2987767 1 NC_002695.1 similar to YEII_ECOLI gi|1788484 (conserved in Escherichia coli K-12); hypothetical protein 2987767 916756 ECs3052 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311079.1 2986679 D 386585 CDS NP_311080.1 15832307 916757 complement(2987823..2989073) 1 NC_002695.1 similar to YEIJ_ECOLI gi|1788485 (conserved in Escherichia coli K-12); transport system permease 2989073 916757 ECs3053 Escherichia coli O157:H7 str. Sakai transport system permease NP_311080.1 2987823 R 386585 CDS NP_311081.1 15832308 916758 complement(2989173..2990114) 1 NC_002695.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2990114 rihB 916758 rihB Escherichia coli O157:H7 str. Sakai ribonucleoside hydrolase 2 NP_311081.1 2989173 R 386585 CDS NP_311082.2 38704059 916759 2990244..2990942 1 NC_002695.1 activator of nucleoside metabolism; YeiL family transcriptional regulator 2990942 916759 ECs3055 Escherichia coli O157:H7 str. Sakai YeiL family transcriptional regulator NP_311082.2 2990244 D 386585 CDS NP_311083.1 15832310 916760 complement(2991013..2992263) 1 NC_002695.1 similar to YEIJ_ECOLI gi|1788485 (conserved in Escherichia coli K-12); transport system permease 2992263 916760 ECs3056 Escherichia coli O157:H7 str. Sakai transport system permease NP_311083.1 2991013 R 386585 CDS NP_311084.1 15832311 916761 complement(2992357..2993295) 1 NC_002695.1 similar to YEIN_ECOLI gi|1788490 (conserved in Escherichia coli K-12); hypothetical protein 2993295 916761 ECs3057 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311084.1 2992357 R 386585 CDS NP_311085.1 15832312 916762 complement(2993283..2994224) 1 NC_002695.1 similar to YEIC_ECOLI gi|1788491 (conserved in Escherichia coli K-12); hypothetical protein 2994224 916762 ECs3058 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311085.1 2993283 R 386585 CDS NP_311086.1 15832313 916763 complement(2994648..2996339) 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC 2996339 916763 ECs3059 Escherichia coli O157:H7 str. Sakai PTS system fructose-specific transporter subunit IIBC NP_311086.1 2994648 R 386585 CDS NP_311087.1 15832314 916764 complement(2996356..2997294) 1 NC_002695.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2997294 fruK 916764 fruK Escherichia coli O157:H7 str. Sakai 1-phosphofructokinase NP_311087.1 2996356 R 386585 CDS NP_311088.1 15832315 916765 complement(2997294..2998424) 1 NC_002695.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2998424 916765 ECs3061 Escherichia coli O157:H7 str. Sakai bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein NP_311088.1 2997294 R 386585 CDS NP_311089.1 15832316 916766 2998792..2999973 1 NC_002695.1 similar to SETB_ECOLI gi|465603|sp|P33026 (conserved in Escherichia coli K-12); sugar efflux transport protein 2999973 916766 ECs3062 Escherichia coli O157:H7 str. Sakai sugar efflux transport protein NP_311089.1 2998792 D 386585 CDS NP_311090.2 38704060 916767 3000379..3000951 1 NC_002695.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 3000951 916767 ECs3063 Escherichia coli O157:H7 str. Sakai elongation factor P NP_311090.2 3000379 D 386585 CDS NP_311091.1 15832318 916768 3001174..3002640 1 NC_002695.1 similar to YEIQ_ECOLI gi|1788497 (conserved in Escherichia coli K-12); oxidoreductase 3002640 916768 ECs3064 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311091.1 3001174 D 386585 CDS NP_311092.1 15832319 916769 3002758..3003744 1 NC_002695.1 similar to YEIR_ECOLI gi|1788499 (conserved in Escherichia coli K-12); hypothetical protein 3003744 916769 ECs3065 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311092.1 3002758 D 386585 CDS NP_311093.2 38704061 916770 3003783..3004496 1 NC_002695.1 similar to B2174_ECOLI gi|1788500 (conserved in Escherichia coli K-12); hypothetical protein 3004496 916770 ECs3066 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311093.2 3003783 D 386585 CDS NP_311094.1 15832321 916771 3004909..3005475 1 NC_002695.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 3005475 spr 916771 spr Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein NP_311094.1 3004909 D 386585 CDS NP_311095.1 15832322 916772 3005656..3007212 1 NC_002695.1 similar to RTN_ECOLI gi|1788502 (conserved in Escherichia coli K-12); hypothetical protein 3007212 916772 ECs3068 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311095.1 3005656 D 386585 CDS NP_311096.2 38704062 916773 3007294..3009108 1 NC_002695.1 similar to YEJA_ECOLI gi|1788503 (conserved in Escherichia coli K-12); hypothetical protein 3009108 916773 ECs3069 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311096.2 3007294 D 386585 CDS NP_311097.1 15832324 916774 3009109..3010203 1 NC_002695.1 similar to YEJB_ECOLI gi|1788504 (conserved in Escherichia coli K-12); transport system permease 3010203 916774 ECs3070 Escherichia coli O157:H7 str. Sakai transport system permease NP_311097.1 3009109 D 386585 CDS NP_311098.1 15832325 916775 3010203..3011228 1 NC_002695.1 similar to YEJE_ECOLI gi|1788505 (conserved in Escherichia coli K-12); transport system permease 3011228 916775 ECs3071 Escherichia coli O157:H7 str. Sakai transport system permease NP_311098.1 3010203 D 386585 CDS NP_311099.1 15832326 916776 3011230..3012819 1 NC_002695.1 similar to YEJF_ECOLI gi|1788506 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 3012819 916776 ECs3072 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311099.1 3011230 D 386585 CDS NP_311100.1 15832327 916777 complement(3012823..3013167) 1 NC_002695.1 similar to YEJG_ECOLI gi|1788507 (conserved in Escherichia coli K-12); hypothetical protein 3013167 916777 ECs3073 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311100.1 3012823 R 386585 CDS NP_311101.1 15832328 916778 complement(3013500..3014690) 1 NC_002695.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 3014690 916778 ECs3074 Escherichia coli O157:H7 str. Sakai bicyclomycin/multidrug efflux system protein NP_311101.1 3013500 R 386585 CDS NP_311102.1 15832329 916779 complement(3014718..3015413) 1 NC_002695.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 3015413 916779 ECs3075 Escherichia coli O157:H7 str. Sakai 16S rRNA pseudouridylate synthase A NP_311102.1 3014718 R 386585 CDS NP_311103.1 15832330 916780 3015562..3017322 1 NC_002695.1 similar to YEJH_ECOLI gi|1788511 (conserved in Escherichia coli K-12); ATP-dependent helicase 3017322 916780 ECs3076 Escherichia coli O157:H7 str. Sakai ATP-dependent helicase NP_311103.1 3015562 D 386585 CDS NP_311104.1 15832331 916782 3017447..3017731 1 NC_002695.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 3017731 916782 ECs3077 Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L25 NP_311104.1 3017447 D 386585 CDS NP_311105.1 15832332 916783 complement(3017870..3018877) 1 NC_002695.1 similar to YEJK_ECOLI gi|465615|sp|P33920 (conserved in Escherichia coli K-12); nucleoid-associated protein NdpA 3018877 916783 ECs3078 Escherichia coli O157:H7 str. Sakai nucleoid-associated protein NdpA NP_311105.1 3017870 R 386585 CDS NP_311106.1 15832333 916784 3019059..3019286 1 NC_002695.1 similar to YEJL_ECOLI gi|1788514 (conserved in Escherichia coli K-12); hypothetical protein 3019286 916784 ECs3079 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311106.1 3019059 D 386585 CDS NP_311107.1 15832334 916785 3019306..3021066 1 NC_002695.1 similar to YEJM_ECOLI gi|1788515 (conserved in Escherichia coli K-12); sulfatase 3021066 916785 ECs3080 Escherichia coli O157:H7 str. Sakai sulfatase NP_311107.1 3019306 D 386585 CDS NP_311108.1 15832335 916787 complement(3021318..3023828) 1 NC_002695.1 similar to YEJO_ECOLI gi|1788516 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 3023828 916787 ECs3081 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311108.1 3021318 R 386585 CDS NP_311109.1 15832336 916788 3024229..3024876 1 NC_002695.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 3024876 916788 ECs3082 Escherichia coli O157:H7 str. Sakai transcriptional regulator NarP NP_311109.1 3024229 D 386585 CDS NP_311110.1 15832337 916789 complement(3024911..3025963) 1 NC_002695.1 similar to CCMH_ECOLI gi|1788522 (conserved in Escherichia coli K-12); cytochrome c-type biogenesis protein; CcmH precursor 3025963 916789 ECs3083 Escherichia coli O157:H7 str. Sakai CcmH precursor NP_311110.1 3024911 R 386585 CDS NP_311111.1 15832338 916790 complement(3025960..3026517) 1 NC_002695.1 similar to DSBE_ECOLI gi|1788523 (conserved in Escherichia coli K-12); thiol:disulfide interchange protein; DsbE 3026517 916790 ECs3084 Escherichia coli O157:H7 str. Sakai DsbE NP_311111.1 3025960 R 386585 CDS NP_311112.1 15832339 916791 complement(3026514..3028457) 1 NC_002695.1 similar to CCMF_ECOLI gi|1788524 (conserved in Escherichia coli K-12); cytochrome c-type biogenesis protein 3028457 916791 ECs3085 Escherichia coli O157:H7 str. Sakai cytochrome c-type biogenesis protein NP_311112.1 3026514 R 386585 CDS NP_311113.1 15832340 916792 complement(3028454..3028933) 1 NC_002695.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 3028933 916792 ECs3086 Escherichia coli O157:H7 str. Sakai cytochrome c-type biogenesis protein CcmE NP_311113.1 3028454 R 386585 CDS NP_311114.1 15832341 916793 complement(3028930..3029139) 1 NC_002695.1 similar to CCMD_ECOLI gi|1788526 (conserved in Escherichia coli K-12); heme exporter protein C 3029139 916793 ECs3087 Escherichia coli O157:H7 str. Sakai heme exporter protein C NP_311114.1 3028930 R 386585 CDS NP_311115.1 15832342 916794 complement(3029136..3029873) 1 NC_002695.1 similar to CCMC_ECOLI gi|1788527 (conserved in Escherichia coli K-12); heme exporter protein C 3029873 916794 ECs3088 Escherichia coli O157:H7 str. Sakai heme exporter protein C NP_311115.1 3029136 R 386585 CDS NP_311116.1 15832343 916795 complement(3029915..3030577) 1 NC_002695.1 similar to CCMB_ECOLI gi|1788528 (conserved in Escherichia coli K-12); heme exporter protein B 3030577 916795 ECs3089 Escherichia coli O157:H7 str. Sakai heme exporter protein B NP_311116.1 3029915 R 386585 CDS NP_311117.1 15832344 916796 complement(3030574..3031191) 1 NC_002695.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 3031191 916796 ECs3090 Escherichia coli O157:H7 str. Sakai cytochrome c biogenesis protein CcmA NP_311117.1 3030574 R 386585 CDS NP_311118.1 15832345 916797 complement(3031210..3031812) 1 NC_002695.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 3031812 916797 ECs3091 Escherichia coli O157:H7 str. Sakai cytochrome c-type protein NapC NP_311118.1 3031210 R 386585 CDS NP_311119.2 38704063 916798 complement(3031822..3032271) 1 NC_002695.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 3032271 napB 916798 napB Escherichia coli O157:H7 str. Sakai citrate reductase cytochrome c-type subunit NP_311119.2 3031822 R 386585 CDS NP_311120.1 15832347 916799 complement(3032268..3033131) 1 NC_002695.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 3033131 napH 916799 napH Escherichia coli O157:H7 str. Sakai quinol dehydrogenase membrane component NP_311120.1 3032268 R 386585 CDS NP_311121.1 15832348 916800 complement(3033118..3033813) 1 NC_002695.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 3033813 napG 916800 napG Escherichia coli O157:H7 str. Sakai quinol dehydrogenase periplasmic component NP_311121.1 3033118 R 386585 CDS NP_311122.1 15832349 916801 complement(3033820..3036306) 1 NC_002695.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 3036306 916801 ECs3095 Escherichia coli O157:H7 str. Sakai nitrate reductase catalytic subunit NP_311122.1 3033820 R 386585 CDS NP_311123.1 15832350 916802 complement(3036303..3036566) 1 NC_002695.1 similar to NAPD_ECOLI gi|1788535 (conserved in Escherichia coli K-12); assembly protein for periplasmic nitrate reductase 3036566 916802 ECs3096 Escherichia coli O157:H7 str. Sakai assembly protein for periplasmic nitrate reductase NP_311123.1 3036303 R 386585 CDS NP_311124.1 15832351 916803 complement(3036556..3037050) 1 NC_002695.1 Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein 3037050 916803 ECs3097 Escherichia coli O157:H7 str. Sakai ferredoxin-type protein NP_311124.1 3036556 R 386585 CDS NP_311125.1 15832352 916804 3037457..3037945 1 NC_002695.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 3037945 916804 ECs3098 Escherichia coli O157:H7 str. Sakai ecotin NP_311125.1 3037457 D 386585 CDS NP_311126.1 15832353 916805 complement(3038095..3039741) 1 NC_002695.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 3039741 916805 ECs3099 Escherichia coli O157:H7 str. Sakai malate:quinone oxidoreductase NP_311126.1 3038095 R 386585 CDS NP_311127.1 15832354 916806 complement(3039959..3041602) 1 NC_002695.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component 3041602 916806 ECs3100 Escherichia coli O157:H7 str. Sakai multidrug transporter membrane protein/ATP-binding component NP_311127.1 3039959 R 386585 CDS NP_311128.1 15832355 916807 complement(3041678..3042328) 1 NC_002695.1 similar to ALKB_ECOLI gi|1788541 (conserved in Escherichia coli K-12); alkylated DNA repair protein 3042328 916807 ECs3101 Escherichia coli O157:H7 str. Sakai alkylated DNA repair protein NP_311128.1 3041678 R 386585 CDS NP_311129.1 15832356 916808 complement(3042328..3043392) 1 NC_002695.1 similar to ADA_ECOLI gi|1788542 (conserved in Escherichia coli K-12); O6-methylguanine-DNA methyltransferase 3043392 916808 ECs3102 Escherichia coli O157:H7 str. Sakai O6-methylguanine-DNA methyltransferase NP_311129.1 3042328 R 386585 CDS NP_944554.1 38704064 2693802 3043126..3043344 1 NC_002695.1 hypothetical protein 3043344 2693802 ECs5484 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944554.1 3043126 D 386585 CDS NP_311130.1 15832357 916810 complement(3043466..3044521) 1 NC_002695.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 3044521 916810 ECs3103 Escherichia coli O157:H7 str. Sakai thiamine biosynthesis lipoprotein ApbE NP_311130.1 3043466 R 386585 CDS NP_311131.1 15832358 916811 complement(3044633..3045736) 1 NC_002695.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 3045736 916811 ECs3104 Escherichia coli O157:H7 str. Sakai outer membrane porin protein C NP_311131.1 3044633 R 386585 CDS NP_311132.1 15832359 916813 3046475..3049147 1 NC_002695.1 similar to YOJN_ECOLI gi|1788545 (conserved in Escherichia coli K-12); phosphotransfer intermediate protein in two-component regulatory system with RcsBC 3049147 916813 ECs3105 Escherichia coli O157:H7 str. Sakai phosphotransfer intermediate protein in two-component regulatory system with RcsBC NP_311132.1 3046475 D 386585 CDS NP_311133.1 15832360 916814 3049164..3049814 1 NC_002695.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 3049814 916814 ECs3106 Escherichia coli O157:H7 str. Sakai transcriptional regulator RcsB NP_311133.1 3049164 D 386585 CDS NP_311134.2 162139775 916815 complement(3050014..3052863) 1 NC_002695.1 similar to RCSC_ECOLI gi|1788548 (conserved in Escherichia coli K-12); hybrid sensory kinase in two-component regulatory system with RcsB and YojN 3052863 916815 ECs3107 Escherichia coli O157:H7 str. Sakai hybrid sensory kinase in two-component regulatory system with RcsB and YojN NP_311134.2 3050014 R 386585 CDS NP_311135.1 15832362 916816 complement(3053138..3053914) 1 NC_002695.1 similar to B2225_ECOLI gi|1788556 (conserved in Escherichia coli K-12); hypothetical protein 3053914 916816 ECs3108 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311135.1 3053138 R 386585 CDS NP_311136.1 15832363 916817 complement(3053919..3054620) 1 NC_002695.1 similar to C-terminal part of B2226_ECOLI gi|1788557; may contain frameshift; hypothetical protein 3054620 916817 ECs3109 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311136.1 3053919 R 386585 CDS NP_311137.1 15832364 916818 complement(3054774..3055568) 1 NC_002695.1 similar to N-terminal part of B2226_ECOLI gi|1788557; may contain frameshift; hypothetical protein 3055568 916818 ECs3110 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311137.1 3054774 R 386585 CDS NP_311138.1 15832365 916819 complement(3055569..3060173) 1 NC_002695.1 similar to membrane protein B2228_ECOLI gi|1788559, B2227_ECOLI to gi|1788558; hypothetical protein 3060173 916819 ECs3111 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311138.1 3055569 R 386585 CDS NP_311139.2 38704065 916820 complement(3060107..3060730) 1 NC_002695.1 similar to B2229_ECOLI gi|1788560 (conserved in Escherichia coli K-12); hypothetical protein 3060730 916820 ECs3112 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311139.2 3060107 R 386585 CDS NP_311140.2 162139774 916821 complement(3060727..3062325) 1 NC_002695.1 similar to YFAA_ECOLI gi|1788561; hypothetical protein 3062325 916821 ECs3113 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311140.2 3060727 R 386585 CDS NP_311141.1 15832368 916822 complement(3062563..3065190) 1 NC_002695.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 3065190 916822 ECs3114 Escherichia coli O157:H7 str. Sakai DNA gyrase subunit A NP_311141.1 3062563 R 386585 CDS NP_311142.1 15832369 916823 3065337..3066059 1 NC_002695.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 3066059 916823 ECs3115 Escherichia coli O157:H7 str. Sakai 3-demethylubiquinone-9 3-methyltransferase NP_311142.1 3065337 D 386585 CDS NP_311143.1 15832370 916824 complement(3066200..3069952) 1 NC_002695.1 similar to YFAL_ECOLI gi|1788565 (conserved in Escherichia coli K-12); adhesin 3069952 916824 ECs3116 Escherichia coli O157:H7 str. Sakai adhesin NP_311143.1 3066200 R 386585 CDS NP_311144.1 15832371 916825 3070648..3072933 1 NC_002695.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3072933 916825 ECs3117 Escherichia coli O157:H7 str. Sakai ribonucleotide-diphosphate reductase subunit alpha NP_311144.1 3070648 D 386585 CDS NP_311145.1 15832372 916826 3073160..3074290 1 NC_002695.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 3074290 nrdB 916826 nrdB Escherichia coli O157:H7 str. Sakai ribonucleotide-diphosphate reductase subunit beta NP_311145.1 3073160 D 386585 CDS NP_311146.1 15832373 916827 3074290..3074544 1 NC_002695.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 3074544 916827 ECs3119 Escherichia coli O157:H7 str. Sakai 2Fe-2S ferredoxin NP_311146.1 3074290 D 386585 CDS NP_311147.1 15832374 916828 complement(3074598..3075248) 1 NC_002695.1 similar to INAA_ECOLI gi|1788569 (conserved in Escherichia coli K-12); hypothetical protein 3075248 916828 ECs3120 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311147.1 3074598 R 386585 CDS NP_311148.1 15832375 916829 complement(3075329..3076519) 1 NC_002695.1 similar to antibiotic resistance protein homolog YwoG [Bacillus subtilis] gi|7474437|pir||B70065; antibiotic resistance protein 3076519 916829 ECs3121 Escherichia coli O157:H7 str. Sakai antibiotic resistance protein NP_311148.1 3075329 R 386585 CDS NP_311149.1 15832376 916830 3076671..3077549 1 NC_002695.1 similar to transcriptional regulators e.g. YvbU [Bacillus subtilis] gi|6648030|sp|O32255; transcriptional regulator 3077549 916830 ECs3122 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311149.1 3076671 D 386585 CDS NP_311150.1 15832377 916831 3078013..3079083 1 NC_002695.1 hypothetical protein 3079083 916831 ECs3123 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311150.1 3078013 D 386585 CDS NP_311151.1 15832378 916832 complement(3079307..3080383) 1 NC_002695.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 3080383 glpQ 916832 glpQ Escherichia coli O157:H7 str. Sakai glycerophosphodiester phosphodiesterase NP_311151.1 3079307 R 386585 CDS NP_311152.1 15832379 916833 complement(3080388..3081746) 1 NC_002695.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 3081746 glpT 916833 glpT Escherichia coli O157:H7 str. Sakai sn-glycerol-3-phosphate transporter NP_311152.1 3080388 R 386585 CDS NP_311153.1 15832380 916834 3082019..3083647 1 NC_002695.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 3083647 glpA 916834 glpA Escherichia coli O157:H7 str. Sakai sn-glycerol-3-phosphate dehydrogenase subunit A NP_311153.1 3082019 D 386585 CDS NP_311154.1 15832381 916835 3083637..3084896 1 NC_002695.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 3084896 916835 ECs3127 Escherichia coli O157:H7 str. Sakai anaerobic glycerol-3-phosphate dehydrogenase subunit B NP_311154.1 3083637 D 386585 CDS NP_311155.1 15832382 916836 3084893..3086083 1 NC_002695.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 3086083 glpC 916836 glpC Escherichia coli O157:H7 str. Sakai sn-glycerol-3-phosphate dehydrogenase subunit C NP_311155.1 3084893 D 386585 CDS NP_311156.1 15832383 916837 3086276..3087202 1 NC_002695.1 similar to YFAD_ECOLI gi|1788577 (conserved in Escherichia coli K-12); hypothetical protein 3087202 916837 ECs3129 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311156.1 3086276 D 386585 CDS NP_311157.1 15832384 916838 complement(3087243..3087995) 1 NC_002695.1 similar to B2245_ECOLI gi|1788578 (conserved in Escherichia coli K-12); aldolase 3087995 916838 ECs3130 Escherichia coli O157:H7 str. Sakai aldolase NP_311157.1 3087243 R 386585 CDS NP_311158.1 15832385 916839 complement(3088063..3088815) 1 NC_002695.1 similar to transport protein B2246_ECOLI gi|1788579; hypothetical protein 3088815 916839 ECs3131 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311158.1 3088063 R 386585 CDS NP_311159.1 15832386 916840 3088892..3089218 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein gi|7444868|pir||T00241; transposase 3089218 916840 ECs3132 Escherichia coli O157:H7 str. Sakai transposase NP_311159.1 3088892 D 386585 CDS NP_311160.1 15832387 916841 3089215..3090105 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 3090105 916841 ECs3133 Escherichia coli O157:H7 str. Sakai transposase NP_311160.1 3089215 D 386585 CDS NP_311161.1 15832388 916842 complement(3090108..3090665) 1 NC_002695.1 similar to B2246_ECOLI gi|1788579; hypothetical protein 3090665 916842 ECs3134 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311161.1 3090108 R 386585 CDS NP_311162.1 15832389 916843 complement(3090722..3091939) 1 NC_002695.1 similar to B2247_ECOLI gi|1788580 (conserved in Escherichia coli K-12); racemase 3091939 916843 ECs3135 Escherichia coli O157:H7 str. Sakai racemase NP_311162.1 3090722 R 386585 CDS NP_311163.1 15832390 916844 complement(3091942..3092724) 1 NC_002695.1 similar to B2248_ECOLI gi|1788581 (conserved in Escherichia coli K-12); regulator 3092724 916844 ECs3136 Escherichia coli O157:H7 str. Sakai regulator NP_311163.1 3091942 R 386585 CDS NP_311164.1 15832391 916845 complement(3092944..3094146) 1 NC_002695.1 similar to B2249_ECOLI gi|1788583 (conserved in Escherichia coli K-12); competence damage-inducible protein A 3094146 916845 ECs3137 Escherichia coli O157:H7 str. Sakai competence damage-inducible protein A NP_311164.1 3092944 R 386585 CDS NP_311165.2 38704066 916846 complement(3094246..3094788) 1 NC_002695.1 similar to B2250_ECOLI gi|1788584 (conserved in Escherichia coli K-12); hypothetical protein 3094788 916846 ECs3138 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311165.2 3094246 R 386585 CDS NP_311166.1 15832393 916847 3095067..3095492 1 NC_002695.1 similar to YFAO_ECOLI gi|1788585 (conserved in Escherichia coli K-12); hypothetical protein 3095492 916847 ECs3139 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311166.1 3095067 D 386585 CDS NP_311167.1 15832394 916848 complement(3095531..3096133) 1 NC_002695.1 similar to AIS_ECOLI gi|1788586 (conserved in Escherichia coli K-12); aluminum-inducible protein 3096133 916848 ECs3140 Escherichia coli O157:H7 str. Sakai aluminum-inducible protein NP_311167.1 3095531 R 386585 CDS NP_311168.3 162139718 916849 3096441..3097580 1 NC_002695.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 3097580 916849 ECs3141 Escherichia coli O157:H7 str. Sakai UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase NP_311168.3 3096441 D 386585 CDS NP_311169.1 15832396 916850 3097584..3098552 1 NC_002695.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 3098552 916850 ECs3142 Escherichia coli O157:H7 str. Sakai undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase NP_311169.1 3097584 D 386585 CDS NP_311170.1 15832397 916851 3098552..3100534 1 NC_002695.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 3100534 916851 ECs3143 Escherichia coli O157:H7 str. Sakai bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase NP_311170.1 3098552 D 386585 CDS NP_311171.1 15832398 916852 3100531..3101421 1 NC_002695.1 similar to B2256_ECOLI gi|1788590 (conserved in Escherichia coli K-12); hypothetical protein 3101421 916852 ECs3144 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311171.1 3100531 D 386585 CDS NP_311172.1 15832399 916853 3101421..3103073 1 NC_002695.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 3103073 arnT 916853 arnT Escherichia coli O157:H7 str. Sakai 4-amino-4-deoxy-L-arabinose transferase NP_311172.1 3101421 D 386585 CDS NP_944555.1 38704068 2693830 3103070..3103405 1 NC_002695.1 hypothetical protein 3103405 2693830 ECs5486 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944555.1 3103070 D 386585 CDS NP_311173.2 38704069 916854 3103405..3103791 1 NC_002695.1 similar to B2258_ECOLI gi|1788592 (conserved in Escherichia coli K-12); hypothetical protein 3103791 916854 ECs3146 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311173.2 3103405 D 386585 CDS NP_311174.1 15832401 916855 complement(3103785..3104081) 1 NC_002695.1 similar to PMRD_ECOLI gi|1788593 (conserved in Escherichia coli K-12); polymyxin resistance protein B 3104081 916855 ECs3147 Escherichia coli O157:H7 str. Sakai polymyxin resistance protein B NP_311174.1 3103785 R 386585 CDS NP_311175.1 15832402 916856 complement(3104161..3105516) 1 NC_002695.1 similar to MENE_ECOLI gi|1788595 (conserved in Escherichia coli K-12); O-succinylbenzoic acid--CoA ligase 3105516 916856 ECs3148 Escherichia coli O157:H7 str. Sakai O-succinylbenzoic acid--CoA ligase NP_311175.1 3104161 R 386585 CDS NP_311176.1 15832403 916857 complement(3105513..3106475) 1 NC_002695.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 3106475 916857 ECs3149 Escherichia coli O157:H7 str. Sakai O-succinylbenzoate synthase NP_311176.1 3105513 R 386585 CDS NP_311177.1 15832404 916858 complement(3106475..3107332) 1 NC_002695.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 3107332 916858 ECs3150 Escherichia coli O157:H7 str. Sakai naphthoate synthase NP_311177.1 3106475 R 386585 CDS NP_311178.1 15832405 916859 complement(3107347..3108105) 1 NC_002695.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 3108105 916859 ECs3151 Escherichia coli O157:H7 str. Sakai acyl-CoA thioester hydrolase NP_311178.1 3107347 R 386585 CDS NP_311179.1 15832406 916860 complement(3108102..3109772) 1 NC_002695.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 3109772 916860 ECs3152 Escherichia coli O157:H7 str. Sakai 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase NP_311179.1 3108102 R 386585 CDS NP_311180.2 38704070 916861 complement(3109861..3111156) 1 NC_002695.1 synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase 3111156 916861 ECs3153 Escherichia coli O157:H7 str. Sakai menaquinone-specific isochorismate synthase NP_311180.2 3109861 R 386585 CDS NP_311181.1 15832408 916862 complement(3111235..3111540) 1 NC_002695.1 similar to ELAB_ECOLI gi|1788601 (conserved in Escherichia coli K-12); hypothetical protein 3111540 916862 ECs3154 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311181.1 3111235 R 386585 CDS NP_311182.1 15832409 916863 complement(3111595..3112056) 1 NC_002695.1 similar to ELAA_ECOLI gi|1788602 (conserved in Escherichia coli K-12); hypothetical protein 3112056 916863 ECs3155 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311182.1 3111595 R 386585 CDS NP_311183.2 162139773 916864 3112121..3113038 1 NC_002695.1 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 3113038 916864 ECs3156 Escherichia coli O157:H7 str. Sakai ribonuclease Z NP_311183.2 3112121 D 386585 CDS NP_311184.1 15832411 916865 3113226..3114449 1 NC_002695.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 3114449 916865 ECs3157 Escherichia coli O157:H7 str. Sakai deubiquitinase NP_311184.1 3113226 D 386585 CDS NP_311185.1 15832412 916866 3115098..3115478 1 NC_002695.1 similar to aminopeptidase YFBL_ECOLI gi|1788607; hypothetical protein 3115478 916866 ECs3158 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311185.1 3115098 D 386585 CDS NP_311186.1 15832413 916867 3115581..3116084 1 NC_002695.1 similar to YFBM_ECOLI gi|1788608 (conserved in Escherichia coli K-12); hypothetical protein 3116084 916867 ECs3159 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311186.1 3115581 D 386585 CDS NP_311187.2 162139772 916868 complement(3116151..3117608) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 3117608 916868 ECs3160 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit N NP_311187.2 3116151 R 386585 CDS NP_311188.1 15832415 916869 complement(3117615..3119144) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 3119144 916869 ECs3161 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit M NP_311188.1 3117615 R 386585 CDS NP_311189.1 15832416 916870 complement(3119375..3121216) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 3121216 916870 ECs3162 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit L NP_311189.1 3119375 R 386585 CDS NP_311190.1 15832417 916871 complement(3121213..3121515) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3121515 916871 ECs3163 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit K NP_311190.1 3121213 R 386585 CDS NP_311191.1 15832418 916872 complement(3121512..3122066) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 3122066 916872 ECs3164 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit J NP_311191.1 3121512 R 386585 CDS NP_311192.1 15832419 916873 complement(3122078..3122620) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 3122620 916873 ECs3165 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit I NP_311192.1 3122078 R 386585 CDS NP_311193.1 15832420 916874 complement(3122635..3123612) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 3123612 916874 ECs3166 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit H NP_311193.1 3122635 R 386585 CDS NP_311194.2 38704071 916875 complement(3123609..3126335) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 3126335 916875 ECs3167 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit G NP_311194.2 3123609 R 386585 CDS NP_311195.1 15832422 916876 complement(3126388..3127725) 1 NC_002695.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 3127725 916876 ECs3168 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase I subunit F NP_311195.1 3126388 R 386585 CDS NP_311196.1 15832423 916877 complement(3127722..3128222) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 3128222 916877 ECs3169 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit E NP_311196.1 3127722 R 386585 CDS NP_311197.1 15832424 916878 complement(3128225..3130027) 1 NC_002695.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 3130027 916878 ECs3170 Escherichia coli O157:H7 str. Sakai bifunctional NADH:ubiquinone oxidoreductase subunit C/D NP_311197.1 3128225 R 386585 CDS NP_311198.1 15832425 916879 complement(3130121..3130783) 1 NC_002695.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 3130783 916879 ECs3171 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit B NP_311198.1 3130121 R 386585 CDS NP_311199.2 38704072 916880 complement(3130799..3131236) 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 3131236 916880 ECs3172 Escherichia coli O157:H7 str. Sakai NADH dehydrogenase subunit A NP_311199.2 3130799 R 386585 CDS NP_311200.1 15832427 916881 complement(3131873..3132811) 1 NC_002695.1 similar to LRHA_ECOLI gi|1788626 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 3132811 916881 ECs3173 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_311200.1 3131873 R 386585 CDS NP_311201.1 15832428 916882 3133731..3134948 1 NC_002695.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 3134948 916882 ECs3174 Escherichia coli O157:H7 str. Sakai aminotransferase NP_311201.1 3133731 D 386585 CDS NP_311202.1 15832429 916883 3135032..3135631 1 NC_002695.1 similar to B2291_ECOLI gi|1788628 (conserved in Escherichia coli K-12); hypothetical protein 3135631 916883 ECs3175 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311202.1 3135032 D 386585 CDS NP_311203.1 15832430 916884 complement(3135690..3137522) 1 NC_002695.1 similar to YFBS_ECOLI gi|1788629 (conserved in Escherichia coli K-12); transporter 3137522 916884 ECs3176 Escherichia coli O157:H7 str. Sakai transporter NP_311203.1 3135690 R 386585 CDS NP_311204.1 15832431 916885 complement(3137609..3138259) 1 NC_002695.1 similar to YFBT_ECOLI gi|1788630 (conserved in Escherichia coli K-12); phosphatase 3138259 916885 ECs3177 Escherichia coli O157:H7 str. Sakai phosphatase NP_311204.1 3137609 R 386585 CDS NP_311205.2 162139771 916886 complement(3138270..3138764) 1 NC_002695.1 similar to B2294_ECOLI gi|1788631 (conserved in Escherichia coli K-12); hypothetical protein 3138764 916886 ECs3178 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311205.2 3138270 R 386585 CDS NP_311206.1 15832433 916887 complement(3138980..3139303) 1 NC_002695.1 similar to N-terminal part of B2295_ECOLI gi|1788632 (conserved in Escherichia coli K-12); hypothetical protein 3139303 916887 ECs3179 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311206.1 3138980 R 386585 CDS NP_311207.1 15832434 916888 3139641..3140843 1 NC_002695.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 3140843 916888 ECs3180 Escherichia coli O157:H7 str. Sakai acetate kinase NP_311207.1 3139641 D 386585 CDS NP_311208.1 15832435 916889 3140918..3143062 1 NC_002695.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 3143062 916889 ECs3181 Escherichia coli O157:H7 str. Sakai phosphate acetyltransferase NP_311208.1 3140918 D 386585 CDS NP_311209.2 162139770 916890 3143252..3144772 1 NC_002695.1 similar to YFCC_ECOLI gi|1788636 (conserved in Escherichia coli K-12); hypothetical protein 3144772 916890 ECs3182 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311209.2 3143252 D 386585 CDS NP_311210.1 15832437 916891 complement(3144805..3145347) 1 NC_002695.1 similar to B2299_ECOLI gi|1788637 (conserved in Escherichia coli K-12); regulator 3145347 916891 ECs3183 Escherichia coli O157:H7 str. Sakai regulator NP_311210.1 3144805 R 386585 CDS NP_311211.2 38704073 916892 complement(3145405..3145956) 1 NC_002695.1 similar to YFCE_ECOLI gi|1788638 (conserved in Escherichia coli K-12); phosphodiesterase 3145956 916892 ECs3184 Escherichia coli O157:H7 str. Sakai phosphodiesterase NP_311211.2 3145405 R 386585 CDS NP_311212.1 15832439 916893 complement(3146012..3146656) 1 NC_002695.1 similar to YFCF_ECOLI gi|1788639 (conserved in Escherichia coli K-12); hypothetical protein 3146656 916893 ECs3185 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311212.1 3146012 R 386585 CDS NP_311213.1 15832440 916894 3146792..3147439 1 NC_002695.1 similar to YFCG_ECOLI gi|1788640 (conserved in Escherichia coli K-12); glutathione S-transferase 3147439 916894 ECs3186 Escherichia coli O157:H7 str. Sakai glutathione S-transferase NP_311213.1 3146792 D 386585 CDS NP_311214.1 15832441 916895 3147496..3147858 1 NC_002695.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 3147858 folX 916895 folX Escherichia coli O157:H7 str. Sakai D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase NP_311214.1 3147496 D 386585 CDS NP_311215.1 15832442 916896 3147879..3148772 1 NC_002695.1 similar to B2304_ECOLI gi|1788642 (conserved in Escherichia coli K-12); sugar nucleotide epimerase 3148772 916896 ECs3188 Escherichia coli O157:H7 str. Sakai sugar nucleotide epimerase NP_311215.1 3147879 D 386585 CDS NP_311216.1 15832443 916897 complement(3148820..3149710) 1 NC_002695.1 similar to YFCI_ECOLI gi|1788643 (conserved in Escherichia coli K-12); hypothetical protein 3149710 916897 ECs3189 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311216.1 3148820 R 386585 CDS NP_311217.1 15832444 916898 complement(3149907..3150680) 1 NC_002695.1 similar to HISP_ECOLI gi|1788644 (conserved in Escherichia coli K-12); histidine/lysine/arginine/ornithine transporter subunit 3150680 916898 ECs3190 Escherichia coli O157:H7 str. Sakai histidine/lysine/arginine/ornithine transporter subunit NP_311217.1 3149907 R 386585 CDS NP_311218.1 15832445 916899 complement(3150688..3151404) 1 NC_002695.1 similar to HISM_ECOLI gi|1788645 (conserved in Escherichia coli K-12); histidine transport system membrane protein M 3151404 916899 ECs3191 Escherichia coli O157:H7 str. Sakai histidine transport system membrane protein M NP_311218.1 3150688 R 386585 CDS NP_311219.1 15832446 916900 complement(3151401..3152087) 1 NC_002695.1 similar to HISQ_ECOLI gi|1788646 (conserved in Escherichia coli K-12); histidine transport system permease 3152087 916900 ECs3192 Escherichia coli O157:H7 str. Sakai histidine transport system permease NP_311219.1 3151401 R 386585 CDS NP_311220.1 15832447 916901 complement(3152177..3152959) 1 NC_002695.1 similar to HISJ_ECOLI gi|1788648 (conserved in Escherichia coli K-12); histidine transport system histidine-binding periplasmic protein 3152959 916901 ECs3193 Escherichia coli O157:H7 str. Sakai histidine transport system histidine-binding periplasmic protein NP_311220.1 3152177 R 386585 CDS NP_311221.1 15832448 916902 complement(3153180..3153962) 1 NC_002695.1 similar to ARGT_ECOLI gi|1788649 (conserved in Escherichia coli K-12); lysine-, arginine-, ornithine-binding periplasmic protein 3153962 916902 ECs3194 Escherichia coli O157:H7 str. Sakai lysine-, arginine-, ornithine-binding periplasmic protein NP_311221.1 3153180 R 386585 CDS NP_311222.1 15832449 916903 complement(3154228..3154797) 1 NC_002695.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 3154797 916903 ECs3195 Escherichia coli O157:H7 str. Sakai 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_311222.1 3154228 R 386585 CDS NP_311223.1 15832450 916904 complement(3154892..3156409) 1 NC_002695.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 3156409 916904 ECs3196 Escherichia coli O157:H7 str. Sakai amidophosphoribosyltransferase NP_311223.1 3154892 R 386585 CDS NP_311224.1 15832451 916905 complement(3156446..3156934) 1 NC_002695.1 membrane protein required for colicin V production; colicin V production protein 3156934 916905 ECs3197 Escherichia coli O157:H7 str. Sakai colicin V production protein NP_311224.1 3156446 R 386585 CDS NP_311225.2 162139769 916906 complement(3157375..3158037) 1 NC_002695.1 similar to DEDD_ECOLI gi|1788653 (conserved in Escherichia coli K-12); hypothetical protein 3158037 916906 ECs3198 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311225.2 3157375 R 386585 CDS NP_311226.1 15832453 916907 complement(3158027..3159295) 1 NC_002695.1 similar to FOLC_ECOLI gi|1788654 (conserved in Escherichia coli K-12); bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 3159295 916907 ECs3199 Escherichia coli O157:H7 str. Sakai bifunctional folylpolyglutamate synthase/ dihydrofolate synthase NP_311226.1 3158027 R 386585 CDS NP_311227.1 15832454 916908 complement(3159365..3160279) 1 NC_002695.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 3160279 916908 ECs3200 Escherichia coli O157:H7 str. Sakai acetyl-CoA carboxylase subunit beta NP_311227.1 3159365 R 386585 CDS NP_311228.1 15832455 917121 complement(3160435..3161094) 1 NC_002695.1 similar to DEDA_ECOLI gi|1788656 (conserved in Escherichia coli K-12); hypothetical protein 3161094 917121 ECs3201 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311228.1 3160435 R 386585 CDS NP_311229.1 15832456 912282 complement(3161177..3161989) 1 NC_002695.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 3161989 truA 912282 truA Escherichia coli O157:H7 str. Sakai tRNA pseudouridine synthase A NP_311229.1 3161177 R 386585 CDS NP_311230.1 15832457 915699 complement(3161989..3163002) 1 NC_002695.1 similar to USG_ECOLI gi|1788658 (conserved in Escherichia coli K-12); semialdehyde dehydrogenase 3163002 915699 ECs3203 Escherichia coli O157:H7 str. Sakai semialdehyde dehydrogenase NP_311230.1 3161989 R 386585 CDS NP_311231.1 15832458 915698 complement(3163068..3164204) 1 NC_002695.1 catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate; erythronate-4-phosphate dehydrogenase 3164204 915698 ECs3204 Escherichia coli O157:H7 str. Sakai erythronate-4-phosphate dehydrogenase NP_311231.1 3163068 R 386585 CDS NP_311232.1 15832459 915697 3164303..3165298 1 NC_002695.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 3165298 flk 915697 flk Escherichia coli O157:H7 str. Sakai flagella biosynthesis regulator NP_311232.1 3164303 D 386585 CDS NP_311233.1 15832460 915695 complement(3165295..3166473) 1 NC_002695.1 similar to B2322_ECOLI gi|1788662 (conserved in Escherichia coli K-12); hypothetical protein 3166473 915695 ECs3206 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311233.1 3165295 R 386585 CDS NP_944556.1 38704074 2693831 3166415..3166636 1 NC_002695.1 hypothetical protein 3166636 2693831 ECs5487 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944556.1 3166415 D 386585 CDS NP_311234.1 15832461 915694 complement(3166748..3167968) 1 NC_002695.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 3167968 915694 ECs3207 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP synthase NP_311234.1 3166748 R 386585 CDS NP_311235.2 38704075 913957 3168127..3170133 1 NC_002695.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 3170133 mnmC 913957 mnmC Escherichia coli O157:H7 str. Sakai 5-methylaminomethyl-2-thiouridine methyltransferase NP_311235.2 3168127 D 386585 CDS NP_311236.1 15832463 917120 complement(3170254..3170532) 1 NC_002695.1 similar to B2325_ECOLI gi|1788665 (conserved in Escherichia coli K-12); hypothetical protein 3170532 917120 ECs3209 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311236.1 3170254 R 386585 CDS NP_311237.1 15832464 915494 complement(3170566..3171114) 1 NC_002695.1 similar to B2326_ECOLI gi|1788666 (conserved in Escherichia coli K-12); transporting ATPase 3171114 915494 ECs3210 Escherichia coli O157:H7 str. Sakai transporting ATPase NP_311237.1 3170566 R 386585 CDS NP_311238.1 15832465 915693 complement(3171114..3171923) 1 NC_002695.1 similar to YFCA_ECOLI gi|1788667 (conserved in Escherichia coli K-12); hypothetical protein 3171923 915693 ECs3211 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311238.1 3171114 R 386585 CDS NP_311239.1 15832466 915692 complement(3171923..3172747) 1 NC_002695.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 3172747 mepA 915692 mepA Escherichia coli O157:H7 str. Sakai penicillin-insensitive murein endopeptidase NP_311239.1 3171923 R 386585 CDS NP_311240.1 15832467 915691 complement(3172751..3173836) 1 NC_002695.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 3173836 915691 ECs3213 Escherichia coli O157:H7 str. Sakai chorismate synthase NP_311240.1 3172751 R 386585 CDS NP_311241.2 38704076 915690 complement(3173871..3174803) 1 NC_002695.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 3174803 915690 ECs3215 Escherichia coli O157:H7 str. Sakai N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_311241.2 3173871 R 386585 CDS NP_311242.1 15832469 915689 3174969..3175520 1 NC_002695.1 similar to B2331_ECOLI gi|1788671 (conserved in Escherichia coli K-12); hypothetical protein 3175520 915689 ECs3214 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311242.1 3174969 D 386585 CDS NP_311243.1 15832470 915688 complement(3175691..3176533) 1 NC_002695.1 similar to B2332_ECOLI gi|7466328|pir||B65006; hypothetical protein 3176533 915688 ECs3216 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311243.1 3175691 R 386585 CDS NP_311244.1 15832471 915687 complement(3176535..3177083) 1 NC_002695.1 similar to B2333_ECOLI gi1788674, minor fimbrial subunit StfG protein [Salmonella typhimurium] dad|AF093503-7|AAC64157.1; fimbrial-like protein 3177083 915687 ECs3217 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_311244.1 3176535 R 386585 CDS NP_311245.1 15832472 915686 complement(3177053..3177523) 1 NC_002695.1 similar to B2334_ECOLI gi|1788675, minor fimbrial subunits e.g. StfF [Salmonella typhimurium] gi3747033; fimbrial protein 3177523 915686 ECs3218 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_311245.1 3177053 R 386585 CDS NP_311246.1 15832473 915685 complement(3177520..3178020) 1 NC_002695.1 similar to B2335_ECOLI gi|1788676, minor fimbrial subunit StfE protein [Salmonella typhimurium] dad|AF093503-5|AAC64155.1; fimbrial protein 3178020 915685 ECs3219 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_311246.1 3177520 R 386585 CDS NP_311247.1 15832474 915684 complement(3178031..3178789) 1 NC_002695.1 similar to YFCS_ECOLI gi|1788677, periplasmic fimbrial chaperone StfD protein [Salmonella typhimurium] dad|AF093503-4|AAC64154.1; chaperone 3178789 915684 ECs3220 Escherichia coli O157:H7 str. Sakai chaperone NP_311247.1 3178031 R 386585 CDS NP_311248.1 15832475 915682 complement(3178812..3181451) 1 NC_002695.1 similar to YFCU_ECOLI gi|1788679, B2337_ECOLI gi|1788678; outer membrane protein 3181451 915682 ECs3221 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_311248.1 3178812 R 386585 CDS NP_311249.1 15832476 915681 complement(3181533..3182096) 1 NC_002695.1 similar to B2339_ECOLI gi|1788680, major fimbrial subunit StfA protein [Salmonella typhimurium ] dad|AF093503-2|AAC64152.1; fimbrial-like protein 3182096 915681 ECs3222 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_311249.1 3181533 R 386585 CDS NP_311250.1 15832477 915680 complement(3182742..3183227) 1 NC_002695.1 similar to B2340_ECOLI gi|1788681 (conserved in Escherichia coli K-12); phosphohistidine phosphatase 3183227 915680 ECs3223 Escherichia coli O157:H7 str. Sakai phosphohistidine phosphatase NP_311250.1 3182742 R 386585 CDS NP_311251.1 15832478 915679 complement(3183430..3185574) 1 NC_002695.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 3185574 fadJ 915679 fadJ Escherichia coli O157:H7 str. Sakai multifunctional fatty acid oxidation complex subunit alpha NP_311251.1 3183430 R 386585 CDS NP_311252.1 15832479 915678 complement(3185574..3186884) 1 NC_002695.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 3186884 fadI 915678 fadI Escherichia coli O157:H7 str. Sakai 3-ketoacyl-CoA thiolase NP_311252.1 3185574 R 386585 CDS NP_311253.2 38704077 915677 complement(3187064..3187348) 1 NC_002695.1 similar to B2343_ECOLI gi|1788685 (conserved in Escherichia coli K-12); hypothetical protein 3187348 915677 ECs3226 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311253.2 3187064 R 386585 CDS NP_311254.1 15832481 915676 3187714..3189060 1 NC_002695.1 similar to FADL_ECOLI gi|1788686 (conserved in Escherichia coli K-12); long-chain fatty acid outer membrane transporter 3189060 915676 ECs3227 Escherichia coli O157:H7 str. Sakai long-chain fatty acid outer membrane transporter NP_311254.1 3187714 D 386585 CDS NP_311255.1 15832482 915675 3189425..3190456 1 NC_002695.1 similar to B2345_ECOLI gi|1788687; hypothetical protein 3190456 915675 ECs3228 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311255.1 3189425 D 386585 CDS NP_311256.1 15832483 915674 complement(3190851..3191606) 1 NC_002695.1 similar to VACJ_ECOLI gi|1788688 (conserved in Escherichia coli K-12); lipoprotein precursor 3191606 915674 ECs3229 Escherichia coli O157:H7 str. Sakai lipoprotein precursor NP_311256.1 3190851 R 386585 CDS NP_311257.1 15832484 915673 3191900..3192832 1 NC_002695.1 similar to YFDC_ECOLI gi|1788689 (conserved in Escherichia coli K-12); transport 3192832 915673 ECs3230 Escherichia coli O157:H7 str. Sakai transport NP_311257.1 3191900 D 386585 CDS NP_311258.1 15832485 915670 3193144..3194301 1 NC_002695.1 similar to INTC_ECOLI gi|1788690 (conserved in Escherichia coli K-12); prophage Sf6-like integrase 3194301 915670 ECs3231 Escherichia coli O157:H7 str. Sakai prophage Sf6-like integrase NP_311258.1 3193144 D 386585 CDS NP_311259.1 15832486 915669 complement(3194476..3195612) 1 NC_002695.1 similar to DNA injection protein gp20 [phage P22] gi|1174950|sp|Q01076|VG20_BPP22; DNA injection protein 3195612 915669 ECs3232 Escherichia coli O157:H7 str. Sakai DNA injection protein NP_311259.1 3194476 R 386585 CDS NP_311260.1 15832487 915668 complement(3195622..3196302) 1 NC_002695.1 similar to DNA transfer protein Gp7 [Bacteriophage P22] gi|418222|sp|Q01074|VG07_BPP22; DNA transfer protein 3196302 915668 ECs3233 Escherichia coli O157:H7 str. Sakai DNA transfer protein NP_311260.1 3195622 R 386585 CDS NP_311261.1 15832488 915667 complement(3196289..3196756) 1 NC_002695.1 similar to hypothetical protein P31 [Bacteriophage APSE-1] gi|6118026|gb|AAF03974.1|AF157835_31, gp14 [Bacteriophage P22] gi|418225|sp|Q01075|VG14_BPP22; hypothetical protein 3196756 915667 ECs3234 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311261.1 3196289 R 386585 CDS NP_311262.1 15832489 915666 complement(3196756..3197043) 1 NC_002695.1 hypothetical protein 3197043 915666 ECs3235 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311262.1 3196756 R 386585 CDS NP_311263.1 15832490 915665 3197308..3198003 1 NC_002695.1 similar to replication proteins e.g. [Haemophilus actinomycetemcomitans Plasmid pVT736-1] gi|398106|gb|AAC37125.1|; replication protein 3198003 915665 ECs3236 Escherichia coli O157:H7 str. Sakai replication protein NP_311263.1 3197308 D 386585 CDS NP_311265.1 15832492 915663 complement(3198673..3200085) 1 NC_002695.1 hypothetical protein 3200085 915663 ECs3238 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311265.1 3198673 R 386585 CDS NP_311266.1 15832493 915661 complement(3200272..3200448) 1 NC_002695.1 hypothetical protein 3200448 915661 ECs3239 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311266.1 3200272 R 386585 CDS NP_311267.1 15832494 915660 3200751..3201377 1 NC_002695.1 similar to resolvases e.g. [Plasmid pM3] gi|5668998|gb|AAD46124.1|AF078924_3, [Yersinia pestis plasmid pMT1] gi|7467461|pir||T14990; resolvase 3201377 915660 ECs3240 Escherichia coli O157:H7 str. Sakai resolvase NP_311267.1 3200751 D 386585 CDS NP_311268.1 15832495 915659 complement(3201975..3203222) 1 NC_002695.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 3203222 lacY 915659 lacY Escherichia coli O157:H7 str. Sakai galactoside permease NP_311268.1 3201975 R 386585 CDS NP_311269.1 15832496 915658 complement(3203294..3204208) 1 NC_002695.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 3204208 915658 ECs3242 Escherichia coli O157:H7 str. Sakai aminoimidazole riboside kinase NP_311269.1 3203294 R 386585 CDS NP_311270.1 15832497 915657 3204424..3205857 1 NC_002695.1 similar to sucrose hydrolase [Escherichia coli strain EC3132] gi|3462879|gb|AAC33123.1; sucrose-6 phosphate hydrolase 3205857 915657 ECs3243 Escherichia coli O157:H7 str. Sakai sucrose-6 phosphate hydrolase NP_311270.1 3204424 D 386585 CDS NP_311271.1 15832498 915656 complement(3205865..3206860) 1 NC_002695.1 similar to sucrose operon repressor [Escherichia coli] gi|729214|sp|P40715|CSCR_ECOLI; sucrose operon repressor 3206860 915656 ECs3244 Escherichia coli O157:H7 str. Sakai sucrose operon repressor NP_311271.1 3205865 R 386585 CDS NP_311272.1 15832499 915655 3207339..3208667 1 NC_002695.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 3208667 915655 ECs3245 Escherichia coli O157:H7 str. Sakai D-serine dehydratase NP_311272.1 3207339 D 386585 CDS NP_311273.1 15832500 915654 complement(3208775..3210313) 1 NC_002695.1 similar to EMRY_ECOLI gi|1788710 (conserved in Escherichia coli K-12); multidrug resistance protein Y 3210313 915654 ECs3246 Escherichia coli O157:H7 str. Sakai multidrug resistance protein Y NP_311273.1 3208775 R 386585 CDS NP_311274.1 15832501 915653 complement(3210313..3211476) 1 NC_002695.1 similar to EMRK_ECOLI gi|1788711 (conserved in Escherichia coli K-12); multidrug resistance protein K 3211476 915653 ECs3247 Escherichia coli O157:H7 str. Sakai multidrug resistance protein K NP_311274.1 3210313 R 386585 CDS NP_311275.1 15832502 915651 3211892..3212506 1 NC_002695.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; EvgA family transcriptional regulator 3212506 915651 ECs3248 Escherichia coli O157:H7 str. Sakai EvgA family transcriptional regulator NP_311275.1 3211892 D 386585 CDS NP_311276.1 15832503 915650 3212511..3216104 1 NC_002695.1 similar to EVGS_ECOLI gi|1788713 (conserved in Escherichia coli K-12); EvgA family transcriptional regulator 3216104 915650 ECs3249 Escherichia coli O157:H7 str. Sakai EvgA family transcriptional regulator NP_311276.1 3212511 D 386585 CDS NP_311277.1 15832504 915649 complement(3216160..3217086) 1 NC_002695.1 similar to YFDE_ECOLI gi|1788714; hypothetical protein 3217086 915649 ECs3250 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311277.1 3216160 R 386585 CDS NP_311278.1 15832505 915648 complement(3217071..3217301) 1 NC_002695.1 similar to YFDE_ECOLI gi|1788714; hypothetical protein 3217301 915648 ECs3251 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311278.1 3217071 R 386585 CDS NP_311279.1 15832506 915647 complement(3217375..3218319) 1 NC_002695.1 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 3218319 915647 ECs3252 Escherichia coli O157:H7 str. Sakai transporter YfdV NP_311279.1 3217375 R 386585 CDS NP_311280.1 15832507 915646 complement(3218389..3220083) 1 NC_002695.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 3220083 915646 ECs3253 Escherichia coli O157:H7 str. Sakai oxalyl-CoA decarboxylase NP_311280.1 3218389 R 386585 CDS NP_311281.1 15832508 915645 complement(3220137..3221387) 1 NC_002695.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 3221387 915645 ECs3254 Escherichia coli O157:H7 str. Sakai formyl-coenzyme A transferase NP_311281.1 3220137 R 386585 CDS NP_311282.1 15832509 915644 complement(3221900..3222535) 1 NC_002695.1 similar to B2375_ECOLI gi|1788719 (conserved in Escherichia coli K-12); hypothetical protein 3222535 915644 ECs3255 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311282.1 3221900 R 386585 CDS NP_311283.1 15832510 915642 3222831..3223106 1 NC_002695.1 similar to B2376_ECOLI gi|2367134 (conserved in Escherichia coli K-12); hypothetical protein 3223106 915642 ECs3256 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311283.1 3222831 D 386585 CDS NP_311284.1 15832511 915641 complement(3223183..3223425) 1 NC_002695.1 similar to B2377_ECOLI gi|1788720 (conserved in Escherichia coli K-12); hypothetical protein 3223425 915641 ECs3257 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311284.1 3223183 R 386585 CDS NP_311285.2 38704078 915640 3223778..3224698 1 NC_002695.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 3224698 915640 ECs3258 Escherichia coli O157:H7 str. Sakai lipid A biosynthesis palmitoleoyl acyltransferase NP_311285.2 3223778 D 386585 CDS NP_311286.1 15832513 915639 complement(3225190..3226428) 1 NC_002695.1 similar to B2379_ECOLI gi|1788722 (conserved in Escherichia coli K-12); aminotransferase 3226428 915639 ECs3259 Escherichia coli O157:H7 str. Sakai aminotransferase NP_311286.1 3225190 R 386585 CDS NP_311287.1 15832514 915638 3226805..3228502 1 NC_002695.1 similar to B2380_ECOLI gi|1788723 (conserved in Escherichia coli K-12); sensor protein 3228502 915638 ECs3260 Escherichia coli O157:H7 str. Sakai sensor protein NP_311287.1 3226805 D 386585 CDS NP_311288.1 15832515 915637 3228517..3229251 1 NC_002695.1 similar to B2381_ECOLI gi|1788724 (conserved in Escherichia coli K-12); 2-component transcriptional regulator 3229251 915637 ECs3261 Escherichia coli O157:H7 str. Sakai 2-component transcriptional regulator NP_311288.1 3228517 D 386585 CDS NP_311289.1 15832516 915636 3229264..3230121 1 NC_002695.1 similar to B2382_ECOLI gi|1788725 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 3230121 915636 ECs3262 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_311289.1 3229264 D 386585 CDS NP_311290.1 15832517 915635 complement(3230124..3232619) 1 NC_002695.1 similar to B2383_ECOLI gi|1788726 (conserved in Escherichia coli K-12); PTS system enzyme IIA component 3232619 915635 ECs3263 Escherichia coli O157:H7 str. Sakai PTS system enzyme IIA component NP_311290.1 3230124 R 386585 CDS NP_311291.1 15832518 915634 complement(3232644..3233681) 1 NC_002695.1 metalloprotein; exoaminopeptidase 3233681 915634 ECs3264 Escherichia coli O157:H7 str. Sakai exoaminopeptidase NP_311291.1 3232644 R 386585 CDS NP_311292.1 15832519 915633 complement(3233681..3234766) 1 NC_002695.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 3234766 915633 ECs3265 Escherichia coli O157:H7 str. Sakai aminopeptidase NP_311292.1 3233681 R 386585 CDS NP_311293.1 15832520 915632 complement(3234781..3236028) 1 NC_002695.1 similar to B2386_ECOLI gi|1788729 (conserved in Escherichia coli K-12); transporter 3236028 915632 ECs3266 Escherichia coli O157:H7 str. Sakai transporter NP_311293.1 3234781 R 386585 CDS NP_311294.1 15832521 915630 complement(3236050..3236376) 1 NC_002695.1 similar to B2387_ECOLI gi|1788730 (conserved in Escherichia coli K-12); PTS system enzyme IIB component 3236376 915630 ECs3267 Escherichia coli O157:H7 str. Sakai PTS system enzyme IIB component NP_311294.1 3236050 R 386585 CDS NP_311295.1 15832522 915629 complement(3236595..3237560) 1 NC_002695.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 3237560 glk 915629 glk Escherichia coli O157:H7 str. Sakai glucokinase NP_311295.1 3236595 R 386585 CDS NP_311296.1 15832523 915628 3237764..3239020 1 NC_002695.1 similar to B2389_ECOLI gi|1788733 (conserved in Escherichia coli K-12); hypothetical protein 3239020 915628 ECs3269 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311296.1 3237764 D 386585 CDS NP_311297.1 15832524 915627 3239135..3239461 1 NC_002695.1 similar to B2390_ECOLI gi|1788734 (conserved in Escherichia coli K-12); hypothetical protein 3239461 915627 ECs3270 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311297.1 3239135 D 386585 CDS NP_311298.1 15832525 915626 complement(3239601..3240839) 1 NC_002695.1 similar to B2392_ECOLI (MntH) gi|1788736|sp|P77145 (conserved in Escherichia coli K-12); manganese transport protein MntH 3240839 915626 ECs3271 Escherichia coli O157:H7 str. Sakai manganese transport protein MntH NP_311298.1 3239601 R 386585 CDS NP_311299.1 15832526 915625 3241175..3242377 1 NC_002695.1 similar to NUPC_ECOLI gi|1788737 (conserved in Escherichia coli K-12); permease of transport system for 3 nucleosides 3242377 915625 ECs3272 Escherichia coli O157:H7 str. Sakai permease of transport system for 3 nucleosides NP_311299.1 3241175 D 386585 CDS NP_311300.1 15832527 915624 complement(3242427..3244616) 1 NC_002695.1 similar to YFEA_ECOLI gi|1788739 (conserved in Escherichia coli K-12); hypothetical protein 3244616 915624 ECs3273 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311300.1 3242427 R 386585 CDS NP_311301.1 15832528 915618 3245235..3245594 1 NC_002695.1 similar to YFEC_ECOLI gi|1788741 (conserved in Escherichia coli K-12); hypothetical protein 3245594 915618 ECs3274 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311301.1 3245235 D 386585 CDS NP_311302.1 15832529 915613 3245596..3245988 1 NC_002695.1 similar to YFED_ECOLI gi|1788742 (conserved in Escherichia coli K-12); hypothetical protein 3245988 915613 ECs3275 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311302.1 3245596 D 386585 CDS NP_311303.2 38704079 915607 complement(3246028..3247236) 1 NC_002695.1 similar to EryA homologue [Bacteriophage If1] dad|U02303-9|AAC62159.1; hypothetical protein 3247236 915607 ECs3276 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311303.2 3246028 R 386585 CDS NP_311304.1 15832531 915604 3247244..3247786 1 NC_002695.1 similar to transposase homolog A [Helicobacter pylori] gi|2114470|gb|AAD11513.1; transposase TnA 3247786 915604 ECs3277 Escherichia coli O157:H7 str. Sakai transposase TnA NP_311304.1 3247244 D 386585 CDS NP_311305.1 15832532 915601 complement(3247787..3249202) 1 NC_002695.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 3249202 gltX 915601 gltX Escherichia coli O157:H7 str. Sakai glutamyl-tRNA synthetase NP_311305.1 3247787 R 386585 CDS NP_311306.1 15832533 915572 3249977..3250318 1 NC_002695.1 similar to FLXA_ECOLI gi|2498386|sp|P77609; hypothetical protein 3250318 915572 ECs3279 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311306.1 3249977 D 386585 CDS NP_311307.1 15832534 915567 complement(3250309..3250659) 1 NC_002695.1 similar to transcriptional regulator YFER_ECOLI gi|1788748; may contain frameshift; hypothetical protein 3250659 915567 ECs3280 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311307.1 3250309 R 386585 CDS NP_311308.1 15832535 915566 complement(3250681..3251235) 1 NC_002695.1 similar to transcriptional regulator YFER_ECOLI gi|1788748; may contain frameshift; hypothetical protein 3251235 915566 ECs3281 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311308.1 3250681 R 386585 CDS NP_311309.1 15832536 915563 3251325..3252323 1 NC_002695.1 similar to YFEH_ECOLI gi|1788749 (conserved in Escherichia coli K-12); cytochrome oxidase 3252323 915563 ECs3282 Escherichia coli O157:H7 str. Sakai cytochrome oxidase NP_311309.1 3251325 D 386585 CDS NP_944557.1 38704080 2693824 complement(3252320..3252538) 1 NC_002695.1 hypothetical protein 3252538 2693824 ECs5495 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944557.1 3252320 R 386585 CDS NP_311310.1 15832537 915555 complement(3252540..3254555) 1 NC_002695.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 3254555 ligA 915555 ligA Escherichia coli O157:H7 str. Sakai NAD-dependent DNA ligase LigA NP_311310.1 3252540 R 386585 CDS NP_311311.1 15832538 915552 complement(3254626..3255624) 1 NC_002695.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 3255624 915552 ECs3284 Escherichia coli O157:H7 str. Sakai cell division protein ZipA NP_311311.1 3254626 R 386585 CDS NP_311312.1 15832539 915545 3255854..3256615 1 NC_002695.1 role in sulfur assimilation; sulfate transport protein CysZ 3256615 915545 ECs3285 Escherichia coli O157:H7 str. Sakai sulfate transport protein CysZ NP_311312.1 3255854 D 386585 CDS NP_311313.1 15832540 915544 3256800..3257771 1 NC_002695.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 3257771 915544 ECs3286 Escherichia coli O157:H7 str. Sakai cysteine synthase A NP_311313.1 3256800 D 386585 CDS NP_311314.1 15832541 915540 3258155..3258412 1 NC_002695.1 similar to PTSH_ECOLI gi|1788755 (conserved in Escherichia coli K-12); PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 3258412 915540 ECs3287 Escherichia coli O157:H7 str. Sakai PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr NP_311314.1 3258155 D 386585 CDS NP_311315.1 15832542 915537 3258457..3260184 1 NC_002695.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 3260184 915537 ECs3288 Escherichia coli O157:H7 str. Sakai phosphoenolpyruvate-protein phosphotransferase NP_311315.1 3258457 D 386585 CDS NP_311316.1 15832543 915535 3260225..3260734 1 NC_002695.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 3260734 915535 ECs3289 Escherichia coli O157:H7 str. Sakai PTS system glucose-specific transporter NP_311316.1 3260225 D 386585 CDS NP_311317.1 15832544 915526 complement(3260777..3261628) 1 NC_002695.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 3261628 pdxK 915526 pdxK Escherichia coli O157:H7 str. Sakai pyridoxal kinase NP_311317.1 3260777 R 386585 CDS NP_311318.1 15832545 915519 3261733..3262065 1 NC_002695.1 similar to YFEK_ECOLI gi|1788759; hypothetical protein 3262065 915519 ECs3291 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311318.1 3261733 D 386585 CDS NP_311319.1 15832546 915515 complement(3262103..3263014) 1 NC_002695.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 3263014 cysM 915515 cysM Escherichia coli O157:H7 str. Sakai cysteine synthase B NP_311319.1 3262103 R 386585 CDS NP_311320.1 15832547 915512 complement(3263148..3264245) 1 NC_002695.1 similar to CYSA_ECOLI gi|1788761 (conserved in Escherichia coli K-12); sulfate/thiosulfate transporter subunit 3264245 915512 ECs3293 Escherichia coli O157:H7 str. Sakai sulfate/thiosulfate transporter subunit NP_311320.1 3263148 R 386585 CDS NP_311321.2 38704081 915509 complement(3264235..3265110) 1 NC_002695.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease 3265110 cysW 915509 cysW Escherichia coli O157:H7 str. Sakai sulfate/thiosulfate transporter permease NP_311321.2 3264235 R 386585 CDS NP_311322.1 15832549 915499 complement(3265110..3265943) 1 NC_002695.1 similar to CYSU_ECOLI gi|1788764 (conserved in Escherichia coli K-12); sulfate/thiosulfate transporter subunit 3265943 915499 ECs3295 Escherichia coli O157:H7 str. Sakai sulfate/thiosulfate transporter subunit NP_311322.1 3265110 R 386585 CDS NP_311323.1 15832550 915491 complement(3265943..3266959) 1 NC_002695.1 similar to CYSP_ECOLI gi|1788765 (conserved in Escherichia coli K-12); thiosulfate transporter subunit 3266959 915491 ECs3296 Escherichia coli O157:H7 str. Sakai thiosulfate transporter subunit NP_311323.1 3265943 R 386585 CDS NP_311324.2 38704082 915487 complement(3267117..3267908) 1 NC_002695.1 similar to UCPA_ECOLI gi|1788766 (conserved in Escherichia coli K-12); short chain dehydrogenase 3267908 915487 ECs3297 Escherichia coli O157:H7 str. Sakai short chain dehydrogenase NP_311324.2 3267117 R 386585 CDS NP_311325.1 15832552 915484 complement(3268037..3268894) 1 NC_002695.1 similar to YFET_ECOLI gi|1788767 (conserved in Escherichia coli K-12); hypothetical protein 3268894 915484 ECs3298 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311325.1 3268037 R 386585 CDS NP_311326.1 15832553 915479 3269058..3269954 1 NC_002695.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 3269954 murQ 915479 murQ Escherichia coli O157:H7 str. Sakai N-acetylmuramic acid 6-phosphate etherase NP_311326.1 3269058 D 386585 CDS NP_311327.1 15832554 915478 3269958..3271382 1 NC_002695.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 3271382 murP 915478 murP Escherichia coli O157:H7 str. Sakai PTS system N-acetylmuramic acid transporter subunit IIBC NP_311327.1 3269958 D 386585 CDS NP_311328.1 15832555 915366 3271387..3272691 1 NC_002695.1 similar to beta-lactamase B2430_ECOLI gi|1788770 (conserved in Escherichia coli K-12); hypothetical protein 3272691 915366 ECs3301 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311328.1 3271387 D 386585 CDS NP_311329.2 38704083 915365 complement(3272749..3273648) 1 NC_002695.1 similar to B2431_ECOLI gi|1788771 (conserved in Escherichia coli K-12); hypothetical protein 3273648 915365 ECs3302 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311329.2 3272749 R 386585 CDS NP_311330.1 15832557 915362 complement(3273744..3274319) 1 NC_002695.1 similar to B2432_ECOLI gi|1788772 (conserved in Escherichia coli K-12); hypothetical protein 3274319 915362 ECs3303 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311330.1 3273744 R 386585 CDS NP_311331.2 38704084 915306 complement(3274380..3274829) 1 NC_002695.1 similar to B2433_ECOLI gi|1788773 (conserved in Escherichia coli K-12); hypothetical protein 3274829 915306 ECs3304 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311331.2 3274380 R 386585 CDS NP_311332.2 38704085 915305 complement(3274816..3275241) 1 NC_002695.1 similar to B2434_ECOLI gi|1788774 (conserved in Escherichia coli K-12); acetyltransferase 3275241 915305 ECs3305 Escherichia coli O157:H7 str. Sakai acetyltransferase NP_311332.2 3274816 R 386585 CDS NP_311333.1 15832560 915304 3275455..3276324 1 NC_002695.1 similar to AMIA_ECOLI gi|1788776 (conserved in Escherichia coli K-12); N-acetylmuramoyl-l-alanine amidase I 3276324 915304 ECs3306 Escherichia coli O157:H7 str. Sakai N-acetylmuramoyl-l-alanine amidase I NP_311333.1 3275455 D 386585 CDS NP_311334.1 15832561 915300 3276328..3277227 1 NC_002695.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 3277227 915300 ECs3307 Escherichia coli O157:H7 str. Sakai coproporphyrinogen III oxidase NP_311334.1 3276328 D 386585 CDS NP_311335.1 15832562 915299 complement(3277233..3278285) 1 NC_002695.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 3278285 915299 ECs3308 Escherichia coli O157:H7 str. Sakai transcriptional regulator EutR NP_311335.1 3277233 R 386585 CDS NP_311336.2 38704086 915298 complement(3278331..3278831) 1 NC_002695.1 similar to B2438_ECOLI gi|1788779 (conserved in Escherichia coli K-12); hypothetical protein 3278831 915298 ECs3309 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311336.2 3278331 R 386585 CDS NP_311337.1 15832564 915297 complement(3278844..3279503) 1 NC_002695.1 similar to B2439_ECOLI gi|1788780 (conserved in Escherichia coli K-12); hypothetical protein 3279503 915297 ECs3310 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311337.1 3278844 R 386585 CDS NP_311338.1 15832565 915296 complement(3279513..3280400) 1 NC_002695.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 3280400 915296 ECs3311 Escherichia coli O157:H7 str. Sakai ethanolamine ammonia-lyase small subunit NP_311338.1 3279513 R 386585 CDS NP_311339.1 15832566 915295 complement(3280421..3281782) 1 NC_002695.1 similar to EUTB_ECOLI gi|1788782 (conserved in Escherichia coli K-12); ethanolamine ammonia-lyase heavy chain 3281782 915295 ECs3312 Escherichia coli O157:H7 str. Sakai ethanolamine ammonia-lyase heavy chain NP_311339.1 3280421 R 386585 CDS NP_311340.1 15832567 915292 complement(3281794..3283197) 1 NC_002695.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 3283197 eutA 915292 eutA Escherichia coli O157:H7 str. Sakai reactivating factor for ethanolamine ammonia lyase NP_311340.1 3281794 R 386585 CDS NP_311341.1 15832568 915290 complement(3283194..3284420) 1 NC_002695.1 similar to EUTH_ECOLI gi|1788794 (conserved in Escherichia coli K-12); ethanolamine utilization protein; EutH 3284420 915290 ECs3314 Escherichia coli O157:H7 str. Sakai EutH NP_311341.1 3283194 R 386585 CDS NP_311342.2 38704087 915288 complement(3284520..3285707) 1 NC_002695.1 similar to EUTG_ECOLI gi|1788795 (conserved in Escherichia coli K-12); hypothetical protein 3285707 915288 ECs3315 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311342.2 3284520 R 386585 CDS NP_311343.1 15832570 915284 complement(3285697..3286533) 1 NC_002695.1 similar to EUTJ_ECOLI gi|1788796 (conserved in Escherichia coli K-12); ethanolamine utilization protein; EutJ 3286533 915284 ECs3316 Escherichia coli O157:H7 str. Sakai EutJ NP_311343.1 3285697 R 386585 CDS NP_311344.1 15832571 915281 complement(3286544..3287947) 1 NC_002695.1 similar to EUTE_ECOLI gi|1788797 (conserved in Escherichia coli K-12); ethanolamine utilization protein; EutE 3287947 915281 ECs3317 Escherichia coli O157:H7 str. Sakai EutE NP_311344.1 3286544 R 386585 CDS NP_311345.1 15832572 915280 complement(3287959..3288246) 1 NC_002695.1 similar to CCHB_ECOLI gi|1788798 (conserved in Escherichia coli K-12); detox protein 3288246 915280 ECs3318 Escherichia coli O157:H7 str. Sakai detox protein NP_311345.1 3287959 R 386585 CDS NP_311346.2 162139768 915278 complement(3288353..3288646) 1 NC_002695.1 similar to CCHA_ECOLI gi|1788799 (conserved in Escherichia coli K-12); detox protein 3288646 915278 ECs3319 Escherichia coli O157:H7 str. Sakai detox protein NP_311346.2 3288353 R 386585 CDS NP_311347.1 15832574 915277 complement(3288685..3289701) 1 NC_002695.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 3289701 eutD 915277 eutD Escherichia coli O157:H7 str. Sakai phosphotransacetylase NP_311347.1 3288685 R 386585 CDS NP_311348.1 15832575 915276 complement(3289698..3290429) 1 NC_002695.1 similar to B2459_ECOLI gi|1788801 (conserved in Escherichia coli K-12); hypothetical protein 3290429 915276 ECs3321 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311348.1 3289698 R 386585 CDS NP_311349.1 15832576 915275 complement(3290426..3291127) 1 NC_002695.1 similar to B2460_ECOLI gi|1788802 (conserved in Escherichia coli K-12); ethanolamine utilization protein EutQ 3291127 915275 ECs3322 Escherichia coli O157:H7 str. Sakai ethanolamine utilization protein EutQ NP_311349.1 3290426 R 386585 CDS NP_311350.1 15832577 913769 complement(3291102..3291581) 1 NC_002695.1 similar to B2461_ECOLI gi|1788803 (conserved in Escherichia coli K-12); hypothetical protein 3291581 913769 ECs3323 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311350.1 3291102 R 386585 CDS NP_311351.2 38704088 917116 complement(3291594..3291929) 1 NC_002695.1 similar to B2462_ECOLI gi|1788804 (conserved in Escherichia coli K-12); hypothetical protein 3291929 917116 ECs3324 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311351.2 3291594 R 386585 CDS NP_311352.1 15832579 915273 complement(3292222..3294501) 1 NC_002695.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 3294501 915273 ECs3325 Escherichia coli O157:H7 str. Sakai malic enzyme NP_311352.1 3292222 R 386585 CDS NP_311353.1 15832580 915272 3294790..3295740 1 NC_002695.1 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase A 3295740 915272 ECs3326 Escherichia coli O157:H7 str. Sakai transaldolase A NP_311353.1 3294790 D 386585 CDS NP_311354.1 15832581 917137 3295760..3297763 1 NC_002695.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3297763 917137 ECs3327 Escherichia coli O157:H7 str. Sakai transketolase NP_311354.1 3295760 D 386585 CDS NP_311355.1 15832582 912782 complement(3297858..3298901) 1 NC_002695.1 similar to B2466_ECOLI gi|1788809 (conserved in Escherichia coli K-12); hypothetical protein 3298901 912782 ECs3328 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311355.1 3297858 R 386585 CDS NP_311356.1 15832583 917127 complement(3299027..3299602) 1 NC_002695.1 similar to YFFH_ECOLI gi|1788810 (conserved in Escherichia coli K-12); hypothetical protein 3299602 917127 ECs3329 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311356.1 3299027 R 386585 CDS NP_311357.1 15832584 912413 complement(3299670..3301649) 1 NC_002695.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3301649 912413 ECs3330 Escherichia coli O157:H7 str. Sakai oxidoreductase Fe-S binding subunit NP_311357.1 3299670 R 386585 CDS NP_311358.1 15832585 915268 3301855..3303555 1 NC_002695.1 similar to NARQ_ECOLI gi|1788812 (conserved in Escherichia coli K-12); nitrate/nitrite sensor protein NarQ 3303555 915268 ECs3331 Escherichia coli O157:H7 str. Sakai nitrate/nitrite sensor protein NarQ NP_311358.1 3301855 D 386585 CDS NP_311359.1 15832586 915267 3303719..3306832 1 NC_002695.1 similar to ACRD_ECOLI gi|1788814 (conserved in Escherichia coli K-12); aminoglycoside/multidrug efflux system 3306832 915267 ECs3332 Escherichia coli O157:H7 str. Sakai aminoglycoside/multidrug efflux system NP_311359.1 3303719 D 386585 CDS NP_311360.1 15832587 915265 3307371..3307727 1 NC_002695.1 similar to YFFB_ECOLI gi|1788815 (conserved in Escherichia coli K-12); hypothetical protein 3307727 915265 ECs3333 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311360.1 3307371 D 386585 CDS NP_311361.1 15832588 915264 3307731..3308858 1 NC_002695.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 3308858 915264 ECs3334 Escherichia coli O157:H7 str. Sakai succinyl-diaminopimelate desuccinylase NP_311361.1 3307731 D 386585 CDS NP_944558.1 38704089 2693833 3308886..3309086 1 NC_002695.1 hypothetical protein 3309086 2693833 ECs5496 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944558.1 3308886 D 386585 CDS NP_311362.2 162139767 915263 complement(3309167..3309865) 1 NC_002695.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3309865 915263 ECs3335 Escherichia coli O157:H7 str. Sakai esterase NP_311362.2 3309167 R 386585 CDS NP_311363.1 15832590 915260 complement(3309939..3311954) 1 NC_002695.1 similar to YPFI_ECOLI gi|1788818 (conserved in Escherichia coli K-12); hypothetical protein 3311954 915260 ECs3336 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311363.1 3309939 R 386585 CDS NP_311364.1 15832591 915256 complement(3311969..3312832) 1 NC_002695.1 similar to B2475_ECOLI gi|1788819 (conserved in Escherichia coli K-12); hypothetical protein 3312832 915256 ECs3337 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311364.1 3311969 R 386585 CDS NP_311365.1 15832592 915199 complement(3313000..3313713) 1 NC_002695.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 3313713 915199 ECs3338 Escherichia coli O157:H7 str. Sakai phosphoribosylaminoimidazole-succinocarboxamide synthase NP_311365.1 3313000 R 386585 CDS NP_311366.2 38704090 915254 complement(3313926..3314960) 1 NC_002695.1 similar to NLPB_ECOLI gi|1788822 (conserved in Escherichia coli K-12); lipoprotein 3314960 915254 ECs3339 Escherichia coli O157:H7 str. Sakai lipoprotein NP_311366.2 3313926 R 386585 CDS NP_311367.1 15832594 915253 complement(3314977..3315855) 1 NC_002695.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 3315855 dapA 915253 dapA Escherichia coli O157:H7 str. Sakai dihydrodipicolinate synthase NP_311367.1 3314977 R 386585 CDS NP_311368.2 38704091 915250 3316001..3316573 1 NC_002695.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 3316573 gcvR 915250 gcvR Escherichia coli O157:H7 str. Sakai glycine cleavage system transcriptional repressor NP_311368.2 3316001 D 386585 CDS NP_311369.1 15832596 915247 3316573..3317043 1 NC_002695.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 3317043 bcp 915247 bcp Escherichia coli O157:H7 str. Sakai thioredoxin-dependent thiol peroxidase NP_311369.1 3316573 D 386585 CDS NP_311370.2 38704092 915246 3317296..3317913 1 NC_002695.1 similar to HYFA_ECOLI gi|1788826 (conserved in Escherichia coli K-12); hydrogenase 4 Fe-S subunit 3317913 915246 ECs3343 Escherichia coli O157:H7 str. Sakai hydrogenase 4 Fe-S subunit NP_311370.2 3317296 D 386585 CDS NP_311371.1 15832598 915245 3317913..3319931 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit B 3319931 915245 ECs3344 Escherichia coli O157:H7 str. Sakai hydrogenase 4 subunit B NP_311371.1 3317913 D 386585 CDS NP_311372.2 38704093 915244 3319942..3320889 1 NC_002695.1 similar to HYFC_ECOLI gi|1788828 (conserved in Escherichia coli K-12); hydrogenase 4 membrane subunit 3320889 915244 ECs3345 Escherichia coli O157:H7 str. Sakai hydrogenase 4 membrane subunit NP_311372.2 3319942 D 386585 CDS NP_311373.1 15832600 915242 3320906..3322345 1 NC_002695.1 similar to HYFD_ECOLI gi|1788829 (conserved in Escherichia coli K-12); hydrogenase 4 subunit D 3322345 915242 ECs3346 Escherichia coli O157:H7 str. Sakai hydrogenase 4 subunit D NP_311373.1 3320906 D 386585 CDS NP_311374.1 15832601 915241 3322357..3323007 1 NC_002695.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 3323007 hyfE 915241 hyfE Escherichia coli O157:H7 str. Sakai hydrogenase 4 membrane subunit NP_311374.1 3322357 D 386585 CDS NP_311375.1 15832602 915239 3323012..3324592 1 NC_002695.1 Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit F 3324592 915239 ECs3348 Escherichia coli O157:H7 str. Sakai hydrogenase 4 subunit F NP_311375.1 3323012 D 386585 CDS NP_311376.1 15832603 915238 3324582..3326297 1 NC_002695.1 similar to HYFG_ECOLI gi|1788832; hydrogenase 4 subunit 3326297 915238 ECs3349 Escherichia coli O157:H7 str. Sakai hydrogenase 4 subunit NP_311376.1 3324582 D 386585 CDS NP_311377.1 15832604 915237 3326307..3326852 1 NC_002695.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 3326852 915237 ECs3350 Escherichia coli O157:H7 str. Sakai hydrogenase 4 subunit H NP_311377.1 3326307 D 386585 CDS NP_311378.1 15832605 915236 3326849..3327607 1 NC_002695.1 similar to HYFI_ECOLI gi|1788834 (conserved in Escherichia coli K-12); hydrogenase 4 Fe-S subunit 3327607 915236 ECs3351 Escherichia coli O157:H7 str. Sakai hydrogenase 4 Fe-S subunit NP_311378.1 3326849 D 386585 CDS NP_311379.1 15832606 915234 3327537..3328013 1 NC_002695.1 similar to B2490_ECOLI gi|1788835 (conserved in Escherichia coli K-12); protein processing element 3328013 915234 ECs3352 Escherichia coli O157:H7 str. Sakai protein processing element NP_311379.1 3327537 D 386585 CDS NP_311380.2 38704094 915230 3328043..3330055 1 NC_002695.1 similar to HYFR_ECOLI gi|1788836 (conserved in Escherichia coli K-12); 2-component regulator 3330055 915230 ECs3353 Escherichia coli O157:H7 str. Sakai 2-component regulator NP_311380.2 3328043 D 386585 CDS NP_311381.1 15832608 915229 3330077..3330925 1 NC_002695.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 3330925 focB 915229 focB Escherichia coli O157:H7 str. Sakai formate transporter NP_311381.1 3330077 D 386585 CDS NP_311382.1 15832609 915228 complement(3330963..3332024) 1 NC_002695.1 similar to PERM_ECOLI gi|1788838 (conserved in Escherichia coli K-12); permease 3332024 915228 ECs3355 Escherichia coli O157:H7 str. Sakai permease NP_311382.1 3330963 R 386585 CDS NP_311383.1 15832610 915227 3332237..3333700 1 NC_002695.1 similar to B2494_ECOLI gi|1788840 (conserved in Escherichia coli K-12); hypothetical protein 3333700 915227 ECs3356 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311383.1 3332237 D 386585 CDS NP_311384.1 15832611 913850 3333721..3334080 1 NC_002695.1 similar to B2495_ECOLI gi|1788841 (conserved in Escherichia coli K-12); oxidoreductase 3334080 913850 ECs3357 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311384.1 3333721 D 386585 CDS NP_311385.1 15832612 917118 complement(3334218..3334964) 1 NC_002695.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 3334964 917118 ECs3358 Escherichia coli O157:H7 str. Sakai DNA replication initiation factor NP_311385.1 3334218 R 386585 CDS NP_311386.1 15832613 915224 complement(3335014..3336303) 1 NC_002695.1 similar to URAA_ECOLI gi|1788843 (conserved in Escherichia coli K-12); uracil transporter 3336303 915224 ECs3359 Escherichia coli O157:H7 str. Sakai uracil transporter NP_311386.1 3335014 R 386585 CDS NP_311387.2 38704095 915222 complement(3336389..3337015) 1 NC_002695.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 3337015 upp 915222 upp Escherichia coli O157:H7 str. Sakai uracil phosphoribosyltransferase NP_311387.2 3336389 R 386585 CDS NP_311388.1 15832615 915220 3337340..3338377 1 NC_002695.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 3338377 915220 ECs3361 Escherichia coli O157:H7 str. Sakai phosphoribosylaminoimidazole synthetase NP_311388.1 3337340 D 386585 CDS NP_311389.1 15832616 917133 3338377..3339015 1 NC_002695.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 3339015 purN 917133 purN Escherichia coli O157:H7 str. Sakai phosphoribosylglycinamide formyltransferase NP_311389.1 3338377 D 386585 CDS NP_311390.1 15832617 912733 3339186..3341252 1 NC_002695.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3341252 912733 ECs3363 Escherichia coli O157:H7 str. Sakai polyphosphate kinase NP_311390.1 3339186 D 386585 CDS NP_311391.1 15832618 914211 3341257..3342798 1 NC_002695.1 similar to PPX_ECOLI gi|1788848 (conserved in Escherichia coli K-12); exopolyphosphatase 3342798 914211 ECs3364 Escherichia coli O157:H7 str. Sakai exopolyphosphatase NP_311391.1 3341257 D 386585 CDS NP_311392.1 15832619 913938 complement(3342837..3345080) 1 NC_002695.1 similar to B2503_ECOLI gi|1788849 (conserved in Escherichia coli K-12); cytochrome C-type biogenesis protein 3345080 913938 ECs3365 Escherichia coli O157:H7 str. Sakai cytochrome C-type biogenesis protein NP_311392.1 3342837 R 386585 CDS NP_944559.1 38704096 2693759 complement(3345262..3345414) 1 NC_002695.1 hypothetical protein 3345414 2693759 ECs5497 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944559.1 3345262 R 386585 CDS NP_311393.1 15832620 915219 3345432..3345623 1 NC_002695.1 similar to B2504_ECOLI gi|1788851 (conserved in Escherichia coli K-12); hypothetical protein 3345623 915219 ECs3366 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311393.1 3345432 D 386585 CDS NP_311394.1 15832621 915218 3345934..3346452 1 NC_002695.1 similar to B2505_ECOLI gi|1788852 (conserved in Escherichia coli K-12); outer membrane lipoprotein 3346452 915218 ECs3367 Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein NP_311394.1 3345934 D 386585 CDS NP_311395.1 15832622 915262 3346468..3347007 1 NC_002695.1 similar to B2506_ECOLI gi|1788853 (conserved in Escherichia coli K-12); hypothetical protein 3347007 915262 ECs3368 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311395.1 3346468 D 386585 CDS NP_311396.1 15832623 912290 complement(3347100..3348677) 1 NC_002695.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 3348677 guaA 912290 guaA Escherichia coli O157:H7 str. Sakai GMP synthase NP_311396.1 3347100 R 386585 CDS NP_311397.1 15832624 917779 complement(3348746..3350212) 1 NC_002695.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 3350212 917779 ECs3370 Escherichia coli O157:H7 str. Sakai inosine 5'-monophosphate dehydrogenase NP_311397.1 3348746 R 386585 CDS NP_311398.1 15832625 912353 3350374..3351744 1 NC_002695.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 3351744 xseA 912353 xseA Escherichia coli O157:H7 str. Sakai exodeoxyribonuclease VII large subunit NP_311398.1 3350374 D 386585 CDS NP_311399.1 15832626 915216 complement(3351741..3351956) 1 NC_002695.1 similar to B2510_ECOLI gi|1788857 (conserved in Escherichia coli K-12); hypothetical protein 3351956 915216 ECs3372 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311399.1 3351741 R 386585 CDS NP_311400.2 162139766 915214 complement(3352025..3353497) 1 NC_002695.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 3353497 engA 915214 engA Escherichia coli O157:H7 str. Sakai GTP-binding protein EngA NP_311400.2 3352025 R 386585 CDS NP_311401.1 15832628 915213 complement(3353615..3354793) 1 NC_002695.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 3354793 915213 ECs3374 Escherichia coli O157:H7 str. Sakai outer membrane protein assembly complex subunit YfgL NP_311401.1 3353615 R 386585 CDS NP_311402.1 15832629 915212 complement(3354804..3355424) 1 NC_002695.1 similar to B2513_ECOLI gi|1788860 (conserved in Escherichia coli K-12); hypothetical protein 3355424 915212 ECs3375 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311402.1 3354804 R 386585 CDS NP_311403.1 15832630 915211 complement(3355442..3356716) 1 NC_002695.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 3356716 hisS 915211 hisS Escherichia coli O157:H7 str. Sakai histidyl-tRNA synthetase NP_311403.1 3355442 R 386585 CDS NP_311404.1 15832631 915209 complement(3356827..3357945) 1 NC_002695.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 3357945 ispG 915209 ispG Escherichia coli O157:H7 str. Sakai 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_311404.1 3356827 R 386585 CDS NP_311405.1 15832632 915208 complement(3357972..3358985) 1 NC_002695.1 similar to YFGA_ECOLI gi|1788864 (conserved in Escherichia coli K-12); cytoskeletal protein RodZ 3358985 915208 ECs3378 Escherichia coli O157:H7 str. Sakai cytoskeletal protein RodZ NP_311405.1 3357972 R 386585 CDS NP_311406.1 15832633 915207 complement(3359270..3360424) 1 NC_002695.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 3360424 915207 ECs3379 Escherichia coli O157:H7 str. Sakai ribosomal RNA large subunit methyltransferase N NP_311406.1 3359270 R 386585 CDS NP_311407.1 15832634 915205 complement(3360574..3361005) 1 NC_002695.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 3361005 ndk 915205 ndk Escherichia coli O157:H7 str. Sakai nucleoside diphosphate kinase NP_311407.1 3360574 R 386585 CDS NP_311408.1 15832635 915204 complement(3361146..3362000) 1 NC_002695.1 similar to ferredoxin [Methanosarcina thermophila] gi|282643|pir||A42960, polyferredoxin [Methanococcus voltae] gi|99156|pir||S24802; polyferredoxin 3362000 915204 ECs3381 Escherichia coli O157:H7 str. Sakai polyferredoxin NP_311408.1 3361146 R 386585 CDS NP_311409.1 15832636 915203 complement(3362000..3362821) 1 NC_002695.1 similar to anaerobic dimethyl sulfoxide reductase chain C e.g. [Escherichia coli] gi|118699|sp|P18777|DMSC_ECOLI; anaerobic dimethyl sulfoxide reductase chain C 3362821 915203 ECs3382 Escherichia coli O157:H7 str. Sakai anaerobic dimethyl sulfoxide reductase chain C NP_311409.1 3362000 R 386585 CDS NP_311410.1 15832637 917134 complement(3362814..3363443) 1 NC_002695.1 similar to anaerobic dimethyl sulfoxide reductases chain B e.g. [Escherichia coli] gi|2506394|sp|P18776|DMSB_ECOLI; anaerobic dimethyl sulfoxide reductase subunit B 3363443 917134 ECs3383 Escherichia coli O157:H7 str. Sakai anaerobic dimethyl sulfoxide reductase subunit B NP_311410.1 3362814 R 386585 CDS NP_311411.1 15832638 912748 complement(3363440..3365821) 1 NC_002695.1 similar to anaerobic dimethyl sulfoxide reductase chain A precursors e.g. [Escherichia coli] gi|118697|sp|P18775|DMSA_ECOLI; anaerobic dimethyl sulfoxide reductase subunit A 3365821 912748 ECs3384 Escherichia coli O157:H7 str. Sakai anaerobic dimethyl sulfoxide reductase subunit A NP_311411.1 3363440 R 386585 CDS NP_311412.1 15832639 912842 complement(3365985..3368297) 1 NC_002695.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 3368297 912842 ECs3385 Escherichia coli O157:H7 str. Sakai penicillin-binding protein 1C NP_311412.1 3365985 R 386585 CDS NP_311413.1 15832640 912952 complement(3368298..3373259) 1 NC_002695.1 similar to B2520_ECOLI gi|1788868 (conserved in Escherichia coli K-12); hypothetical protein 3373259 912952 ECs3386 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311413.1 3368298 R 386585 CDS NP_311414.2 38704097 915202 3373466..3374311 1 NC_002695.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 3374311 sseA 915202 sseA Escherichia coli O157:H7 str. Sakai 3-mercaptopyruvate sulfurtransferase NP_311414.2 3373466 D 386585 CDS NP_311415.2 38704098 917135 complement(3374811..3375587) 1 NC_002695.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 3375587 917135 ECs3388 Escherichia coli O157:H7 str. Sakai enhanced serine sensitivity protein SseB NP_311415.2 3374811 R 386585 CDS NP_311416.2 38704099 912754 complement(3375730..3377013) 1 NC_002695.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 3377013 912754 ECs3389 Escherichia coli O157:H7 str. Sakai aminopeptidase NP_311416.2 3375730 R 386585 CDS NP_311417.1 15832644 913777 complement(3377191..3377391) 1 NC_002695.1 similar to YFHJ_ECOLI gi|1788873 (conserved in Escherichia coli K-12); hypothetical protein 3377391 913777 ECs3390 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311417.1 3377191 R 386585 CDS NP_311418.1 15832645 917117 complement(3377403..3377738) 1 NC_002695.1 similar to FER_ECOLI gi|119999|sp|P25528 (conserved in Escherichia coli K-12); [2FE-2S] ferredoxin 3377738 917117 ECs3391 Escherichia coli O157:H7 str. Sakai [2FE-2S] ferredoxin NP_311418.1 3377403 R 386585 CDS NP_311419.1 15832646 915196 complement(3377740..3379590) 1 NC_002695.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 3379590 hscA 915196 hscA Escherichia coli O157:H7 str. Sakai chaperone protein HscA NP_311419.1 3377740 R 386585 CDS NP_311420.1 15832647 915200 complement(3379607..3380122) 1 NC_002695.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 3380122 hscB 915200 hscB Escherichia coli O157:H7 str. Sakai co-chaperone HscB NP_311420.1 3379607 R 386585 CDS NP_311421.1 15832648 915168 complement(3380218..3380541) 1 NC_002695.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 3380541 iscA 915168 iscA Escherichia coli O157:H7 str. Sakai iron-sulfur cluster assembly protein NP_311421.1 3380218 R 386585 CDS NP_311422.1 15832649 915163 complement(3380558..3380944) 1 NC_002695.1 similar to ISCU_ECOLI gi|7387937|sp|P77310 (conserved in Escherichia coli K-12); scaffold protein 3380944 915163 ECs3395 Escherichia coli O157:H7 str. Sakai scaffold protein NP_311422.1 3380558 R 386585 CDS NP_311423.2 38704100 915161 complement(3380972..3382186) 1 NC_002695.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 3382186 915161 ECs3396 Escherichia coli O157:H7 str. Sakai cysteine desulfurase NP_311423.2 3380972 R 386585 CDS NP_311424.1 15832651 915159 complement(3382298..3382786) 1 NC_002695.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 3382786 915159 ECs3397 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator IscR NP_311424.1 3382298 R 386585 CDS NP_311425.1 15832652 915158 complement(3383087..3383824) 1 NC_002695.1 similar to B2532_ECOLI (YhfQ) gi|1788881 (conserved in Escherichia coli K-12); ATP synthase subunit beta 3383824 915158 ECs3398 Escherichia coli O157:H7 str. Sakai ATP synthase subunit beta NP_311425.1 3383087 R 386585 CDS NP_311426.1 15832653 915157 3383943..3384746 1 NC_002695.1 similar to SUHB_ECOLI gi|1788882 (conserved in Escherichia coli K-12); inositol monophosphatase 3384746 915157 ECs3399 Escherichia coli O157:H7 str. Sakai inositol monophosphatase NP_311426.1 3383943 D 386585 CDS NP_311427.2 38704101 915154 3384891..3385745 1 NC_002695.1 similar to B2534_ECOLI gi|1788884 (conserved in Escherichia coli K-12); hypothetical protein 3385745 915154 ECs3400 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311427.2 3384891 D 386585 CDS NP_311428.2 162139765 915085 3385936..3387216 1 NC_002695.1 similar to CSIE_ECOLI gi|1788885 (conserved in Escherichia coli K-12); stationary phase inducible protein CsiE 3387216 915085 ECs3401 Escherichia coli O157:H7 str. Sakai stationary phase inducible protein CsiE NP_311428.2 3385936 D 386585 CDS NP_311429.1 15832656 915038 complement(3387208..3388347) 1 NC_002695.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 3388347 915038 ECs3402 Escherichia coli O157:H7 str. Sakai 3-phenylpropionic acid transporter NP_311429.1 3387208 R 386585 CDS NP_311430.1 15832657 914136 complement(3388507..3389397) 1 NC_002695.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 3389397 914136 ECs3403 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator HcaR NP_311430.1 3388507 R 386585 CDS NP_311431.1 15832658 913881 3389533..3390894 1 NC_002695.1 similar to HCAA1_ECOLI gi|1788888 (conserved in Escherichia coli K-12); phenylpropionate dioxygenase large terminal subunit 3390894 913881 ECs3404 Escherichia coli O157:H7 str. Sakai phenylpropionate dioxygenase large terminal subunit NP_311431.1 3389533 D 386585 CDS NP_311432.1 15832659 914927 3390891..3391409 1 NC_002695.1 similar to HCAA2_ECOLI gi|1788889 (conserved in Escherichia coli K-12); 3-phenylpropionate dioxygenase subunit beta 3391409 914927 ECs3405 Escherichia coli O157:H7 str. Sakai 3-phenylpropionate dioxygenase subunit beta NP_311432.1 3390891 D 386585 CDS NP_311433.1 15832660 914928 3391409..3391729 1 NC_002695.1 similar to HCAC_ECOLI gi|1788890 (conserved in Escherichia coli K-12); 3-phenylpropionate dioxygenase ferredoxin subunit 3391729 914928 ECs3406 Escherichia coli O157:H7 str. Sakai 3-phenylpropionate dioxygenase ferredoxin subunit NP_311433.1 3391409 D 386585 CDS NP_311434.1 15832661 914919 3391726..3392538 1 NC_002695.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 3392538 914919 ECs3407 Escherichia coli O157:H7 str. Sakai 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase NP_311434.1 3391726 D 386585 CDS NP_311435.1 15832662 914925 3392548..3393750 1 NC_002695.1 similar to HCAD_ECOLI gi|1788892 (conserved in Escherichia coli K-12); phenylpropionate dioxygenase ferredoxin reductase subunit 3393750 914925 ECs3408 Escherichia coli O157:H7 str. Sakai phenylpropionate dioxygenase ferredoxin reductase subunit NP_311435.1 3392548 D 386585 CDS NP_311436.2 38704102 914923 3393847..3394269 1 NC_002695.1 similar to YPHA_ECOLI gi|1788893 (conserved in Escherichia coli K-12); hypothetical protein 3394269 914923 ECs3409 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311436.2 3393847 D 386585 CDS NP_311437.1 15832664 914921 complement(3394317..3395189) 1 NC_002695.1 similar to YPHB_ECOLI gi|1788894 (conserved in Escherichia coli K-12); hypothetical protein 3395189 914921 ECs3410 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311437.1 3394317 R 386585 CDS NP_311438.1 15832665 914924 complement(3395201..3395989) 1 NC_002695.1 similar to YPHC_ECOLI gi|1788895; hypothetical protein 3395989 914924 ECs3411 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311438.1 3395201 R 386585 CDS NP_944560.1 38704103 2693756 complement(3396071..3396295) 1 NC_002695.1 hypothetical protein 3396295 2693756 ECs5498 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944560.1 3396071 R 386585 CDS NP_311439.1 15832666 914920 complement(3396328..3397326) 1 NC_002695.1 similar to YPHD_ECOLI gi|1788896 (conserved in Escherichia coli K-12); transport system permease 3397326 914920 ECs3412 Escherichia coli O157:H7 str. Sakai transport system permease NP_311439.1 3396328 R 386585 CDS NP_311440.1 15832667 914917 complement(3397351..3398862) 1 NC_002695.1 similar to YPHE_ECOLI gi|1788897 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 3398862 914917 ECs3413 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311440.1 3397351 R 386585 CDS NP_311441.1 15832668 914918 complement(3398885..3399868) 1 NC_002695.1 similar to YPHF_ECOLI gi|1788898 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator 3399868 914918 ECs3414 Escherichia coli O157:H7 str. Sakai LACI-type transcriptional regulator NP_311441.1 3398885 R 386585 CDS NP_311442.1 15832669 914914 complement(3399965..3403339) 1 NC_002695.1 similar to YPHG_ECOLI gi|1788900 (conserved in Escherichia coli K-12); hypothetical protein 3403339 914914 ECs3415 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311442.1 3399965 R 386585 CDS NP_311443.2 38704104 914916 3403364..3404557 1 NC_002695.1 similar to YPHH_ECOLI gi|1788901 (conserved in Escherichia coli K-12); NAGC-like transcriptional regulator 3404557 914916 ECs3416 Escherichia coli O157:H7 str. Sakai NAGC-like transcriptional regulator NP_311443.2 3403364 D 386585 CDS NP_311444.1 15832671 914911 complement(3404620..3405873) 1 NC_002695.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 3405873 glyA 914911 glyA Escherichia coli O157:H7 str. Sakai serine hydroxymethyltransferase NP_311444.1 3404620 R 386585 CDS NP_311445.1 15832672 914915 3406201..3407391 1 NC_002695.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 3407391 914915 ECs3418 Escherichia coli O157:H7 str. Sakai nitric oxide dioxygenase NP_311445.1 3406201 D 386585 CDS NP_311446.1 15832673 914897 complement(3407436..3407774) 1 NC_002695.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 3407774 914897 ECs3419 Escherichia coli O157:H7 str. Sakai nitrogen regulatory protein P-II 1 NP_311446.1 3407436 R 386585 CDS NP_311447.1 15832674 914905 complement(3407835..3409169) 1 NC_002695.1 similar to YFHA_ECOLI gi|1788905 (conserved in Escherichia coli K-12); 2-component transcriptional regulator 3409169 914905 ECs3420 Escherichia coli O157:H7 str. Sakai 2-component transcriptional regulator NP_311447.1 3407835 R 386585 CDS NP_311448.1 15832675 914899 complement(3409159..3409872) 1 NC_002695.1 similar to YFHG_ECOLI gi|1788906 (conserved in Escherichia coli K-12); hypothetical protein 3409872 914899 ECs3421 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311448.1 3409159 R 386585 CDS NP_311449.1 15832676 914903 complement(3410037..3411527) 1 NC_002695.1 similar to YFHK_ECOLI gi|1788908 (conserved in Escherichia coli K-12); 2-component sensor protein 3411527 914903 ECs3422 Escherichia coli O157:H7 str. Sakai 2-component sensor protein NP_311449.1 3410037 R 386585 CDS NP_311450.1 15832677 914912 complement(3412040..3415927) 1 NC_002695.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 3415927 914912 ECs3423 Escherichia coli O157:H7 str. Sakai phosphoribosylformylglycinamidine synthase NP_311450.1 3412040 R 386585 CDS NP_311451.1 15832678 914913 3416322..3417740 1 NC_002695.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 3417740 914913 ECs3424 Escherichia coli O157:H7 str. Sakai transglycosylase NP_311451.1 3416322 D 386585 CDS NP_311452.1 15832679 914909 complement(3417737..3418273) 1 NC_002695.1 similar to YFHC_ECOLI gi|1788911 (conserved in Escherichia coli K-12); tRNA-specific adenosine deaminase 3418273 914909 ECs3425 Escherichia coli O157:H7 str. Sakai tRNA-specific adenosine deaminase NP_311452.1 3417737 R 386585 CDS NP_311453.2 38704105 914902 complement(3418298..3418933) 1 NC_002695.1 similar to YFHB_ECOLI gi|1788912 (conserved in Escherichia coli K-12); hypothetical protein 3418933 914902 ECs3426 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311453.2 3418298 R 386585 CDS NP_311454.2 162139764 914910 3419142..3419990 1 NC_002695.1 similar to YFHH_ECOLI gi|1788913 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 3419990 914910 ECs3427 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_311454.2 3419142 D 386585 CDS NP_311455.1 15832682 914901 3420046..3420306 1 NC_002695.1 similar to YFHL_ECOLI gi|1788914 (conserved in Escherichia coli K-12); hypothetical protein 3420306 914901 ECs3428 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311455.1 3420046 D 386585 CDS NP_311456.1 15832683 914898 complement(3421002..3421382) 1 NC_002695.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 3421382 acpS 914898 acpS Escherichia coli O157:H7 str. Sakai 4'-phosphopantetheinyl transferase NP_311456.1 3421002 R 386585 CDS NP_311457.1 15832684 914900 complement(3421382..3422113) 1 NC_002695.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 3422113 914900 ECs3430 Escherichia coli O157:H7 str. Sakai pyridoxine 5'-phosphate synthase NP_311457.1 3421382 R 386585 CDS NP_311458.1 15832685 914896 complement(3422125..3422853) 1 NC_002695.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 3422853 recO 914896 recO Escherichia coli O157:H7 str. Sakai DNA repair protein RecO NP_311458.1 3422125 R 386585 CDS NP_311459.1 15832686 914890 complement(3422865..3423770) 1 NC_002695.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 3423770 era 914890 era Escherichia coli O157:H7 str. Sakai GTP-binding protein Era NP_311459.1 3422865 R 386585 CDS NP_311460.1 15832687 914894 complement(3423767..3424447) 1 NC_002695.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 3424447 rnc 914894 rnc Escherichia coli O157:H7 str. Sakai ribonuclease III NP_311460.1 3423767 R 386585 CDS NP_311461.1 15832688 914889 complement(3424720..3425694) 1 NC_002695.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 3425694 914889 ECs3434 Escherichia coli O157:H7 str. Sakai signal peptidase I NP_311461.1 3424720 R 386585 CDS NP_311462.1 15832689 915772 complement(3425710..3427509) 1 NC_002695.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 3427509 915772 ECs3435 Escherichia coli O157:H7 str. Sakai GTP-binding protein LepA NP_311462.1 3425710 R 386585 CDS NP_311463.1 15832690 914892 complement(3427707..3428186) 1 NC_002695.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 3428186 914892 ECs3436 Escherichia coli O157:H7 str. Sakai SoxR reducing system protein RseC NP_311463.1 3427707 R 386585 CDS NP_311464.1 15832691 914893 complement(3428183..3429139) 1 NC_002695.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 3429139 rseB 914893 rseB Escherichia coli O157:H7 str. Sakai periplasmic negative regulator of sigmaE NP_311464.1 3428183 R 386585 CDS NP_311465.1 15832692 914891 complement(3429139..3429777) 1 NC_002695.1 similar to RSEA_ECOLI gi|1788925 (conserved in Escherichia coli K-12); anti-RNA polymerase sigma factor SigE 3429777 914891 ECs3438 Escherichia coli O157:H7 str. Sakai anti-RNA polymerase sigma factor SigE NP_311465.1 3429139 R 386585 CDS NP_311466.1 15832693 914887 complement(3429810..3430385) 1 NC_002695.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 3430385 914887 ECs3439 Escherichia coli O157:H7 str. Sakai RNA polymerase sigma factor RpoE NP_311466.1 3429810 R 386585 CDS NP_311467.1 15832694 914886 3430793..3432415 1 NC_002695.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 3432415 914886 ECs3440 Escherichia coli O157:H7 str. Sakai L-aspartate oxidase NP_311467.1 3430793 D 386585 CDS NP_311468.1 15832695 914885 complement(3432400..3433257) 1 NC_002695.1 similar to YFIC_ECOLI gi|1788929 (conserved in Escherichia coli K-12); hypothetical protein 3433257 914885 ECs3441 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311468.1 3432400 R 386585 CDS NP_311469.1 15832696 914884 3433269..3434603 1 NC_002695.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 3434603 914884 ECs3442 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase SrmB NP_311469.1 3433269 D 386585 CDS NP_311470.2 38704106 914883 complement(3434636..3435517) 1 NC_002695.1 similar to YFIE_ECOLI gi|1788931 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 3435517 914883 ECs3443 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_311470.2 3434636 R 386585 CDS NP_311471.1 15832698 914882 3435620..3436207 1 NC_002695.1 similar to YFIK_ECOLI gi|1788932 (conserved in Escherichia coli K-12); neutral amino-acid efflux protein 3436207 914882 ECs3444 Escherichia coli O157:H7 str. Sakai neutral amino-acid efflux protein NP_311471.1 3435620 D 386585 CDS NP_311472.1 15832699 914881 complement(3436263..3436646) 1 NC_002695.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 3436646 914881 ECs3445 Escherichia coli O157:H7 str. Sakai autonomous glycyl radical cofactor GrcA NP_311472.1 3436263 R 386585 CDS NP_311473.1 15832700 914880 3436951..3437607 1 NC_002695.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 3437607 914880 ECs3446 Escherichia coli O157:H7 str. Sakai uracil-DNA glycosylase NP_311473.1 3436951 D 386585 CDS NP_311474.1 15832701 914879 complement(3437689..3438726) 1 NC_002695.1 similar to YFIF_ECOLI gi|1788935 (conserved in Escherichia coli K-12); methyltransferase 3438726 914879 ECs3447 Escherichia coli O157:H7 str. Sakai methyltransferase NP_311474.1 3437689 R 386585 CDS NP_311475.1 15832702 914878 3438933..3439352 1 NC_002695.1 similar to TRXC_ECOLI gi|1788936 (conserved in Escherichia coli K-12); thioredoxin 2 3439352 914878 ECs3448 Escherichia coli O157:H7 str. Sakai thioredoxin 2 NP_311475.1 3438933 D 386585 CDS NP_311476.2 38704107 914877 3439421..3440119 1 NC_002695.1 similar to YFIP_ECOLI gi|1788937 (conserved in Escherichia coli K-12); hypothetical protein 3440119 914877 ECs3449 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311476.2 3439421 D 386585 CDS NP_311479.2 38704108 914873 3442926..3444281 1 NC_002695.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 3444281 pssA 914873 pssA Escherichia coli O157:H7 str. Sakai phosphatidylserine synthase NP_311479.2 3442926 D 386585 CDS NP_311480.1 15832707 914872 3444378..3444650 1 NC_002695.1 similar to YFIM_ECOLI gi|1788941 (conserved in Escherichia coli K-12); hypothetical protein 3444650 914872 ECs3453 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311480.1 3444378 D 386585 CDS NP_311481.1 15832708 914871 complement(3444647..3445945) 1 NC_002695.1 similar to KGTP_ECOLI gi|1788942 (conserved in Escherichia coli K-12); alpha-ketoglutarate transporter 3445945 914871 ECs3454 Escherichia coli O157:H7 str. Sakai alpha-ketoglutarate transporter NP_311481.1 3444647 R 386585 CDS NP_311482.1 15832709 914865 complement(3451719..3454292) 1 NC_002695.1 similar to CLPB_ECOLI gi|1788943 (conserved in Escherichia coli K-12); protein disaggregation chaperone 3454292 914865 ECs3455 Escherichia coli O157:H7 str. Sakai protein disaggregation chaperone NP_311482.1 3451719 R 386585 CDS NP_311483.1 15832710 914864 complement(3454422..3455153) 1 NC_002695.1 similar to YFIH_ECOLI gi|1788945 (conserved in Escherichia coli K-12); hypothetical protein 3455153 914864 ECs3456 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311483.1 3454422 R 386585 CDS NP_311484.1 15832711 914863 complement(3455150..3456130) 1 NC_002695.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 3456130 rluD 914863 rluD Escherichia coli O157:H7 str. Sakai 23S rRNA pseudouridine synthase D NP_311484.1 3455150 R 386585 CDS NP_311485.1 15832712 914862 3456265..3457002 1 NC_002695.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 3457002 914862 ECs3458 Escherichia coli O157:H7 str. Sakai outer membrane protein assembly complex subunit YfiO NP_311485.1 3456265 D 386585 CDS NP_311486.1 15832713 914861 3457032..3457238 1 NC_002695.1 similar to B2596_ECOLI gi|1788948 (conserved in Escherichia coli K-12); hypothetical protein 3457238 914861 ECs3459 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311486.1 3457032 D 386585 CDS NP_311487.1 15832714 914860 3457273..3457614 1 NC_002695.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 3457614 914860 ECs3460 Escherichia coli O157:H7 str. Sakai translation inhibitor protein RaiA NP_311487.1 3457273 D 386585 CDS NP_311489.1 15832716 914858 3457864..3459024 1 NC_002695.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 3459024 pheA 914858 pheA Escherichia coli O157:H7 str. Sakai bifunctional chorismate mutase/prephenate dehydratase NP_311489.1 3457864 D 386585 CDS NP_311490.1 15832717 914857 complement(3459067..3460188) 1 NC_002695.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 3460188 tyrA 914857 tyrA Escherichia coli O157:H7 str. Sakai bifunctional chorismate mutase/prephenate dehydrogenase NP_311490.1 3459067 R 386585 CDS NP_311491.1 15832718 914856 complement(3460199..3461269) 1 NC_002695.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 3461269 914856 ECs3464 Escherichia coli O157:H7 str. Sakai phospho-2-dehydro-3-deoxyheptonate aldolase NP_311491.1 3460199 R 386585 CDS NP_311492.1 15832719 914855 3461440..3461844 1 NC_002695.1 similar to YFIL_ECOLI gi|1788954 (conserved in Escherichia coli K-12); hypothetical protein 3461844 914855 ECs3465 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311492.1 3461440 D 386585 CDS NP_311493.1 15832720 914829 3461994..3462512 1 NC_002695.1 similar to B2603_ECOLI gi|1788955 (conserved in Escherichia coli K-12); hypothetical protein 3462512 914829 ECs3466 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311493.1 3461994 D 386585 CDS NP_311494.1 15832721 914822 3462502..3463728 1 NC_002695.1 similar to YFIN_ECOLI gi|1788956 (conserved in Escherichia coli K-12); hypothetical protein 3463728 914822 ECs3467 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311494.1 3462502 D 386585 CDS NP_311495.1 15832722 914820 3463744..3464226 1 NC_002695.1 similar to YFIB_ECOLI gi|1788957 (conserved in Escherichia coli K-12); outer membrane lipoprotein 3464226 914820 ECs3468 Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein NP_311495.1 3463744 D 386585 CDS NP_311496.1 15832723 914819 complement(3464303..3464650) 1 NC_002695.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 3464650 rplS 914819 rplS Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L19 NP_311496.1 3464303 R 386585 CDS NP_311497.1 15832724 914818 complement(3464692..3465459) 1 NC_002695.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 3465459 trmD 914818 trmD Escherichia coli O157:H7 str. Sakai tRNA (guanine-N(1)-)-methyltransferase NP_311497.1 3464692 R 386585 CDS NP_311498.3 162139719 914817 complement(3465490..3466038) 1 NC_002695.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 3466038 rimM 914817 rimM Escherichia coli O157:H7 str. Sakai 16S rRNA-processing protein RimM NP_311498.3 3465490 R 386585 CDS NP_311499.1 15832726 914816 complement(3466057..3466305) 1 NC_002695.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 3466305 rpsP 914816 rpsP Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S16 NP_311499.1 3466057 R 386585 CDS NP_311500.1 15832727 914815 complement(3466442..3467803) 1 NC_002695.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 3467803 914815 ECs3473 Escherichia coli O157:H7 str. Sakai signal recognition particle protein NP_311500.1 3466442 R 386585 CDS NP_311501.2 38704110 914814 3467970..3468761 1 NC_002695.1 similar to B2611_ECOLI gi|1788964 (conserved in Escherichia coli K-12); hypothetical protein 3468761 914814 ECs3474 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311501.2 3467970 D 386585 CDS NP_311502.1 15832729 914813 3468873..3470069 1 NC_002695.1 similar to YPJE_ECOLI gi|1788965, YFJD_ECOLI gi|1788966; hypothetical protein 3470069 914813 ECs3475 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311502.1 3468873 D 386585 CDS NP_311503.1 15832730 914812 complement(3470124..3470717) 1 NC_002695.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 3470717 914812 ECs3476 Escherichia coli O157:H7 str. Sakai heat shock protein GrpE NP_311503.1 3470124 R 386585 CDS NP_311504.1 15832731 914811 3470840..3471718 1 NC_002695.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3471718 ppnK 914811 ppnK Escherichia coli O157:H7 str. Sakai inorganic polyphosphate/ATP-NAD kinase NP_311504.1 3470840 D 386585 CDS NP_311505.1 15832732 914810 3471804..3473465 1 NC_002695.1 similar to RECN_ECOLI gi|1788969 (conserved in Escherichia coli K-12); recombination and repair protein 3473465 914810 ECs3478 Escherichia coli O157:H7 str. Sakai recombination and repair protein NP_311505.1 3471804 D 386585 CDS NP_311506.1 15832733 914809 3473803..3473955 1 NC_002695.1 similar to SMPA_ECOLI gi|1788970 (conserved in Escherichia coli K-12); small membrane protein A 3473955 914809 ECs3479 Escherichia coli O157:H7 str. Sakai small membrane protein A NP_311506.1 3473803 D 386585 CDS NP_311507.2 162139763 914808 complement(3474017..3474307) 1 NC_002695.1 similar to B2618_ECOLI gi|1788971 (conserved in Escherichia coli K-12); hypothetical protein 3474307 914808 ECs3480 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311507.2 3474017 R 386585 CDS NP_311508.1 15832735 914807 complement(3474297..3474773) 1 NC_002695.1 similar to B2619_ECOLI gi|1788972 (conserved in Escherichia coli K-12); hypothetical protein 3474773 914807 ECs3481 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311508.1 3474297 R 386585 CDS NP_311509.1 15832736 914806 3474905..3475387 1 NC_002695.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3475387 smpB 914806 smpB Escherichia coli O157:H7 str. Sakai SsrA-binding protein NP_311509.1 3474905 D 386585 CDS NP_311510.1 15832737 914804 3476233..3476481 1 NC_002695.1 similar to DNA damage-inducible proteins e.g. DinI [Escherichia coli] gi|2498305|sp|Q47143|DINI_ECOLI; DNA damage-inducible protein 3476481 914804 ECs3483 Escherichia coli O157:H7 str. Sakai DNA damage-inducible protein NP_311510.1 3476233 D 386585 CDS NP_311512.1 15832739 914802 complement(3476983..3477573) 1 NC_002695.1 similar to TrcA-like proteins e.g. bfpT-regulated chaperone-like protein TrcA [Escherichia coli strain B171-8] gi|4126789|dbj|BAA36747.1|; chaperone-like protein 3477573 914802 ECs3485 Escherichia coli O157:H7 str. Sakai chaperone-like protein NP_311512.1 3476983 R 386585 CDS NP_311513.1 15832740 914800 3477756..3478406 1 NC_002695.1 similar to hypothetical proteins e.g. ORF2 [Escherichia coli strain B171-8] gi|4126790|dbj|BAA36748.1|; hypothetical protein 3478406 914800 ECs3486 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311513.1 3477756 D 386585 CDS NP_311514.1 15832741 914799 3478485..3479543 1 NC_002695.1 similar to hypothetical protein ORF3 [Escherichia coli strain B171-8] gi|4126791|dbj|BAA36749.1|; hypothetical protein 3479543 914799 ECs3487 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311514.1 3478485 D 386585 CDS NP_311515.1 15832742 914798 complement(3479673..3480095) 1 NC_002695.1 similar to hypothetical proteins e.g. ORF4 [Escherichia coli strain B171-8] gi|4126792|dbj|BAA36750.1|; hypothetical protein 3480095 914798 ECs3488 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311515.1 3479673 R 386585 CDS NP_311516.1 15832743 914797 complement(3480256..3480645) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585437|gb|AAD25465.1|AF125520_60; hypothetical protein 3480645 914797 ECs3489 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311516.1 3480256 R 386585 CDS NP_311517.1 15832744 914796 3480743..3481069 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7444868|pir||T00241, hypothetical proteins of IS elements e.g. TnpE [Shigella flexneri] gi|5532454|gb|AAD44738.1|AF141323_9; transposase 3481069 914796 ECs3490 Escherichia coli O157:H7 str. Sakai transposase NP_311517.1 3480743 D 386585 CDS NP_311518.1 15832745 914795 3481066..3481956 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 insertion sequence IS629] gi|7443862|pir||T00240; transposase 3481956 914795 ECs3491 Escherichia coli O157:H7 str. Sakai transposase NP_311518.1 3481066 D 386585 CDS NP_311519.1 15832746 914794 complement(3481763..3482260) 1 NC_002695.1 similar to hypothetical protein L0015 Escherichia coli O157:H7 strain EDL933 AAC31494; hypothetical protein 3482260 914794 ECs3492 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311519.1 3481763 R 386585 CDS NP_311520.1 15832747 914793 complement(3482457..3482804) 1 NC_002695.1 similar to hypothetical protein L0014 [Escherichia coli O157:H7 strain EDL933] gi|3288157|emb|CAA11510.1|, similar tohypothetical proteins e.g. ORF50 [Escherichia coli] gi|6009426|dbj|BAA84885.1|; hypothetical protein 3482804 914793 ECs3493 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311520.1 3482457 R 386585 CDS NP_311521.1 15832748 914792 complement(3482801..3483181) 1 NC_002695.1 similar to hypothetical proteins e.g. L0013 [Escherichia coli O157:H7 strain EDL933] gi|3414881|gb|AAC31492.1|; hypothetical protein 3483181 914792 ECs3494 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311521.1 3482801 R 386585 CDS NP_311523.1 15832750 914790 complement(3483538..3483882) 1 NC_002695.1 similar to hypothetical protein YdfR [Escherichia coli] gi|3183262|sp|P76160|YDFR_ECOLI; hypothetical protein 3483882 914790 ECs3496 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311523.1 3483538 R 386585 CDS NP_311524.1 15832751 914789 complement(3483887..3484102) 1 NC_002695.1 host cell lysis; similar to holins e.g. [Bacteriophage VT2-Sa] gi|5881636|dbj|BAA84327.1|; holin 3484102 914789 ECs3497 Escherichia coli O157:H7 str. Sakai holin NP_311524.1 3483887 R 386585 CDS NP_311525.1 15832752 914788 complement(3484252..3486105) 1 NC_002695.1 similar to hypothetical protein [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 3486105 914788 ECs3498 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311525.1 3484252 R 386585 CDS NP_311526.1 15832753 914787 3486346..3486675 1 NC_002695.1 hypothetical protein 3486675 914787 ECs3499 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311526.1 3486346 D 386585 CDS NP_311527.2 38704111 914786 complement(3486766..3487482) 1 NC_002695.1 similar to hypothetical protein [Actinobacillus actinomycetemcomitans] gi|7592819|dbj|BAA94406.1; hypothetical protein 3487482 914786 ECs3500 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311527.2 3486766 R 386585 CDS NP_311528.1 15832755 914785 complement(3487762..3488385) 1 NC_002695.1 similar to antitermination proteins e.g. protein Q [Bacteriophage lambda] gi|132278|sp|P03047|REGQ_LAMBD; antitermination protein 3488385 914785 ECs3501 Escherichia coli O157:H7 str. Sakai antitermination protein NP_311528.1 3487762 R 386585 CDS NP_311529.1 15832756 914783 complement(3488382..3489047) 1 NC_002695.1 similar to serine/threonine protein phosphatases e.g. [Bacteriophage lambda] gi|130792|sp|P03772|PP_LAMBD; serine/threonine protein phosphatase 3489047 914783 ECs3502 Escherichia coli O157:H7 str. Sakai serine/threonine protein phosphatase NP_311529.1 3488382 R 386585 CDS NP_311530.1 15832757 914782 complement(3489044..3489655) 1 NC_002695.1 similar to hypothetical proteins e.g. NinG [Bacteriophage 21] gi|4539482|emb|CAB39991.1|; hypothetical protein 3489655 914782 ECs3503 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311530.1 3489044 R 386585 CDS NP_311531.1 15832758 914781 complement(3489630..3490196) 1 NC_002695.1 similar to phage hypothetical proteins e.g. [Bacteriophage phi-YeO3-12] gi|6598993|emb|CAB63597.1|; hypothetical protein 3490196 914781 ECs3504 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311531.1 3489630 R 386585 CDS NP_311533.1 15832760 914779 3491224..3491619 1 NC_002695.1 lipoprotein 3491619 914779 ECs3506 Escherichia coli O157:H7 str. Sakai lipoprotein NP_311533.1 3491224 D 386585 CDS NP_311534.1 15832761 914778 complement(3491695..3492963) 1 NC_002695.1 hypothetical protein 3492963 914778 ECs3507 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311534.1 3491695 R 386585 CDS NP_311535.1 15832762 914777 complement(3493359..3493772) 1 NC_002695.1 hypothetical protein 3493772 914777 ECs3508 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311535.1 3493359 R 386585 CDS NP_311536.1 15832763 914776 complement(3493870..3494268) 1 NC_002695.1 hypothetical protein 3494268 914776 ECs3509 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311536.1 3493870 R 386585 CDS NP_311537.1 15832764 914775 complement(3494269..3495900) 1 NC_002695.1 similar to ctp synthase - Rickettsia prowasekii C71695, hypothetical protein Plasmodium falciparum CAB39033; hypothetical protein 3495900 914775 ECs3510 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311537.1 3494269 R 386585 CDS NP_311538.1 15832765 914774 complement(3495897..3497210) 1 NC_002695.1 hypothetical protein 3497210 914774 ECs3511 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311538.1 3495897 R 386585 CDS NP_311539.1 15832766 914773 complement(3497212..3498417) 1 NC_002695.1 probable integrase; similar to site specific recombinases e.g. integrase-recombinase [Methanobacterium thermoautotrophicum] gi|7428936|pir||D69219; site specific recombinase 3498417 914773 ECs3512 Escherichia coli O157:H7 str. Sakai site specific recombinase NP_311539.1 3497212 R 386585 CDS NP_311540.1 15832767 914772 complement(3498740..3498946) 1 NC_002695.1 similar to Bacteriophage P4 DNA-binding protein P12552 and Yersinia pestis hypothetical protein T17447; DNA binding protein 3498946 914772 ECs3513 Escherichia coli O157:H7 str. Sakai DNA binding protein NP_311540.1 3498740 R 386585 CDS NP_311541.1 15832768 914771 complement(3499046..3499897) 1 NC_002695.1 hypothetical protein 3499897 914771 ECs3514 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311541.1 3499046 R 386585 CDS NP_311542.1 15832769 914770 complement(3500324..3505039) 1 NC_002695.1 similar to YPJA_ECOLI gi|1789001 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 3505039 914770 ECs3515 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311542.1 3500324 R 386585 CDS NP_311544.1 15832771 914768 complement(3505846..3507195) 1 NC_002695.1 similar to B2650_ECOLI gi|1789004, B2649_ECOLI gi|1789003; hypothetical protein 3507195 914768 ECs3517 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311544.1 3505846 R 386585 CDS NP_311545.1 15832772 914766 3508583..3509821 1 NC_002695.1 similar to B2654_ECOLI gi|1789007, B2655_ECOLI similar to gi|1789008; hypothetical protein 3509821 914766 ECs3518 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311545.1 3508583 D 386585 CDS NP_311546.1 15832773 914765 3509828..3510835 1 NC_002695.1 similar to B2657_ECOLI gi|1789010, B2658_ECOLI gi|1789012; hypothetical protein 3510835 914765 ECs3519 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311546.1 3509828 D 386585 CDS NP_311547.2 38704112 914764 3511172..3512149 1 NC_002695.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3512149 914764 ECs3520 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311547.2 3511172 D 386585 CDS NP_311548.1 15832775 914763 3512103..3513437 1 NC_002695.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3513437 914763 ECs3521 Escherichia coli O157:H7 str. Sakai hydroxyglutarate oxidase NP_311548.1 3512103 D 386585 CDS NP_311549.1 15832776 914762 3513460..3514908 1 NC_002695.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3514908 gabD 914762 gabD Escherichia coli O157:H7 str. Sakai succinate-semialdehyde dehydrogenase I NP_311549.1 3513460 D 386585 CDS NP_311550.1 15832777 914761 3514922..3516202 1 NC_002695.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3516202 914761 ECs3523 Escherichia coli O157:H7 str. Sakai 4-aminobutyrate aminotransferase NP_311550.1 3514922 D 386585 CDS NP_311551.1 15832778 914760 3516440..3517840 1 NC_002695.1 similar to GABP_ECOLI gi|1789017 (conserved in Escherichia coli K-12); gamma-aminobutyrate transporter 3517840 914760 ECs3524 Escherichia coli O157:H7 str. Sakai gamma-aminobutyrate transporter NP_311551.1 3516440 D 386585 CDS NP_311552.2 38704113 914759 3517861..3518523 1 NC_002695.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3518523 914759 ECs3525 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator CsiR NP_311552.2 3517861 D 386585 CDS NP_311553.1 15832780 914758 complement(3518524..3518973) 1 NC_002695.1 similar to YGAU_ECOLI gi|1789019 (conserved in Escherichia coli K-12); LysM domain/BON superfamily protein 3518973 914758 ECs3526 Escherichia coli O157:H7 str. Sakai LysM domain/BON superfamily protein NP_311553.1 3518524 R 386585 CDS NP_311554.1 15832781 914757 complement(3519057..3519215) 1 NC_002695.1 similar to B2666_ECOLI gi|1789020 (conserved in Escherichia coli K-12); hypothetical protein 3519215 914757 ECs3527 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311554.1 3519057 R 386585 CDS NP_311555.1 15832782 914756 3519398..3519697 1 NC_002695.1 similar to B2667_ECOLI gi|1789021 (conserved in Escherichia coli K-12); hypothetical protein 3519697 914756 ECs3528 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311555.1 3519398 D 386585 CDS NP_311556.1 15832783 914755 3519707..3520225 1 NC_002695.1 similar to YGAP_ECOLI gi|1789022 (conserved in Escherichia coli K-12); hypothetical protein 3520225 914755 ECs3529 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311556.1 3519707 D 386585 CDS NP_311557.1 15832784 914754 complement(3520278..3520682) 1 NC_002695.1 similar to STPA_ECOLI gi|1789023 (conserved in Escherichia coli K-12); DNA binding protein 3520682 914754 ECs3530 Escherichia coli O157:H7 str. Sakai DNA binding protein NP_311557.1 3520278 R 386585 CDS NP_311558.1 15832785 914753 3521350..3521799 1 NC_002695.1 similar to B2670_ECOLI gi|1789025 (conserved in Escherichia coli K-12); hypothetical protein 3521799 914753 ECs3531 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311558.1 3521350 D 386585 CDS NP_311559.1 15832786 914752 complement(3521836..3522180) 1 NC_002695.1 similar to YGAC_ECOLI gi|1789026 (conserved in Escherichia coli K-12); hypothetical protein 3522180 914752 ECs3532 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311559.1 3521836 R 386585 CDS NP_311560.2 38704114 914751 3522332..3522661 1 NC_002695.1 similar to YGAM_ECOLI gi|1789027 (conserved in Escherichia coli K-12); hypothetical protein 3522661 914751 ECs3533 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311560.2 3522332 D 386585 CDS NP_311561.1 15832788 914750 complement(3522811..3524145) 1 NC_002695.1 similar to regulatory proteins e.g. MocR [Sinorhizobium meliloti] gi|1346565|sp|P49309; transcriptional regulator 3524145 914750 ECs3534 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311561.1 3522811 R 386585 CDS NP_311562.1 15832789 914749 3524233..3524664 1 NC_002695.1 similar to conserved hypothetical protein [Streptomyces coelicolor A3(2)] gi|7649565|emb|CAB89054.1; hypothetical protein 3524664 914749 ECs3535 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311562.1 3524233 D 386585 CDS NP_311563.1 15832790 914748 3524873..3525118 1 NC_002695.1 similar to NRDH_ECOLI gi|1789028 (conserved in Escherichia coli K-12); glutaredoxin-like protein 3525118 914748 ECs3536 Escherichia coli O157:H7 str. Sakai glutaredoxin-like protein NP_311563.1 3524873 D 386585 CDS NP_311564.1 15832791 914747 3525115..3525525 1 NC_002695.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3525525 nrdI 914747 nrdI Escherichia coli O157:H7 str. Sakai ribonucleotide reductase stimulatory protein NP_311564.1 3525115 D 386585 CDS NP_311565.1 15832792 914746 3525498..3527642 1 NC_002695.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3527642 914746 ECs3538 Escherichia coli O157:H7 str. Sakai ribonucleotide-diphosphate reductase subunit alpha NP_311565.1 3525498 D 386585 CDS NP_311566.1 15832793 914745 3527652..3528611 1 NC_002695.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3528611 nrdF 914745 nrdF Escherichia coli O157:H7 str. Sakai ribonucleotide-diphosphate reductase subunit beta NP_311566.1 3527652 D 386585 CDS NP_311567.1 15832794 914744 3528967..3530169 1 NC_002695.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding protein 3530169 914744 ECs3540 Escherichia coli O157:H7 str. Sakai glycine betaine transporter ATP-binding protein NP_311567.1 3528967 D 386585 CDS NP_311568.1 15832795 914743 3530162..3531226 1 NC_002695.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3531226 914743 ECs3541 Escherichia coli O157:H7 str. Sakai glycine betaine transporter membrane protein NP_311568.1 3530162 D 386585 CDS NP_311569.1 15832796 914742 3531283..3532275 1 NC_002695.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3532275 proX 914742 proX Escherichia coli O157:H7 str. Sakai glycine betaine transporter periplasmic subunit NP_311569.1 3531283 D 386585 CDS NP_311570.1 15832797 914741 3532467..3533651 1 NC_002695.1 similar to B2680_ECOLI gi|1789035, B2681_ECOLI gi|1789036; transporter 3533651 914741 ECs3543 Escherichia coli O157:H7 str. Sakai transporter NP_311570.1 3532467 D 386585 CDS NP_311571.1 15832798 914740 3533775..3534512 1 NC_002695.1 similar to B2682_ECOLI gi|1789038 (conserved in Escherichia coli K-12); hypothetical protein 3534512 914740 ECs3544 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311571.1 3533775 D 386585 CDS NP_311572.1 15832799 914739 3534502..3534837 1 NC_002695.1 similar to YGAH_ECOLI gi|1789039 (conserved in Escherichia coli K-12); hypothetical protein 3534837 914739 ECs3545 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311572.1 3534502 D 386585 CDS NP_311573.1 15832800 914738 3534928..3535458 1 NC_002695.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3535458 914738 ECs3546 Escherichia coli O157:H7 str. Sakai transcriptional repressor MprA NP_311573.1 3534928 D 386585 CDS NP_311574.1 15832801 914737 3535585..3536757 1 NC_002695.1 similar to EMRA_ECOLI gi|1789041 (conserved in Escherichia coli K-12); multidrug resistance secretion protein 3536757 914737 ECs3547 Escherichia coli O157:H7 str. Sakai multidrug resistance secretion protein NP_311574.1 3535585 D 386585 CDS NP_311575.1 15832802 914736 3536774..3538312 1 NC_002695.1 similar to EMRB_ECOLI gi|1789042 (conserved in Escherichia coli K-12); multidrug resistance protein B 3538312 914736 ECs3548 Escherichia coli O157:H7 str. Sakai multidrug resistance protein B NP_311575.1 3536774 D 386585 CDS NP_311576.1 15832803 914734 complement(3538376..3538891) 1 NC_002695.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 3538891 914734 ECs3549 Escherichia coli O157:H7 str. Sakai S-ribosylhomocysteinase NP_311576.1 3538376 R 386585 CDS NP_311577.1 15832804 914733 complement(3539041..3540597) 1 NC_002695.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 3540597 914733 ECs3550 Escherichia coli O157:H7 str. Sakai glutamate--cysteine ligase NP_311577.1 3539041 R 386585 CDS NP_311578.1 15832805 914732 complement(3540670..3541098) 1 NC_002695.1 similar to B2689_ECOLI gi|1789045 (conserved in Escherichia coli K-12); hypothetical protein 3541098 914732 ECs3551 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311578.1 3540670 R 386585 CDS NP_311579.1 15832806 914731 complement(3541095..3541661) 1 NC_002695.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 3541661 914731 ECs3552 Escherichia coli O157:H7 str. Sakai fructose-1-phosphatase NP_311579.1 3541095 R 386585 CDS NP_311580.1 15832807 914725 complement(3542889..3543074) 1 NC_002695.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 3543074 914725 ECs3553 Escherichia coli O157:H7 str. Sakai carbon storage regulator NP_311580.1 3542889 R 386585 CDS NP_311581.1 15832808 914724 complement(3543309..3545939) 1 NC_002695.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 3545939 alaS 914724 alaS Escherichia coli O157:H7 str. Sakai alanyl-tRNA synthetase NP_311581.1 3543309 R 386585 CDS NP_311582.1 15832809 914723 complement(3546067..3546567) 1 NC_002695.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3546567 recX 914723 recX Escherichia coli O157:H7 str. Sakai recombination regulator RecX NP_311582.1 3546067 R 386585 CDS NP_311583.1 15832810 914722 complement(3546635..3547696) 1 NC_002695.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3547696 recA 914722 recA Escherichia coli O157:H7 str. Sakai recombinase A NP_311583.1 3546635 R 386585 CDS NP_311584.1 15832811 914721 complement(3547776..3548273) 1 NC_002695.1 similar to YGAD_ECOLI gi|1789052 (conserved in Escherichia coli K-12); competence damage-inducible protein A 3548273 914721 ECs3557 Escherichia coli O157:H7 str. Sakai competence damage-inducible protein A NP_311584.1 3547776 R 386585 CDS NP_311585.1 15832812 914720 complement(3548418..3549503) 1 NC_002695.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 3549503 914720 ECs3558 Escherichia coli O157:H7 str. Sakai murein hydrolase B NP_311585.1 3548418 R 386585 CDS NP_311587.1 15832814 914718 3551284..3551655 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3551655 914718 ECs3560 Escherichia coli O157:H7 str. Sakai PTS system glucitol/sorbitol-specific transporter subunit IIA NP_311587.1 3551284 D 386585 CDS NP_311588.1 15832815 914717 3551659..3552438 1 NC_002695.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3552438 914717 ECs3561 Escherichia coli O157:H7 str. Sakai sorbitol-6-phosphate dehydrogenase NP_311588.1 3551659 D 386585 CDS NP_311589.1 15832816 914716 3552544..3552903 1 NC_002695.1 regulator for glucitol utilization; GutM family transcriptional regulator 3552903 914716 ECs3562 Escherichia coli O157:H7 str. Sakai GutM family transcriptional regulator NP_311589.1 3552544 D 386585 CDS NP_311590.1 15832817 914715 3552970..3553743 1 NC_002695.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3553743 srlR 914715 srlR Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor SrlR NP_311590.1 3552970 D 386585 CDS NP_311591.2 38704115 914714 3553736..3554701 1 NC_002695.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3554701 gutQ 914714 gutQ Escherichia coli O157:H7 str. Sakai D-arabinose 5-phosphate isomerase NP_311591.2 3553736 D 386585 CDS NP_311592.2 162139762 914713 complement(3554698..3556212) 1 NC_002695.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 3556212 914713 ECs3565 Escherichia coli O157:H7 str. Sakai anaerobic nitric oxide reductase transcriptional regulator NP_311592.2 3554698 R 386585 CDS NP_311593.1 15832820 914712 3556399..3557634 1 NC_002695.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3557634 914712 ECs3566 Escherichia coli O157:H7 str. Sakai anaerobic nitric oxide reductase flavorubredoxin NP_311593.1 3556399 D 386585 CDS NP_311594.1 15832821 914711 3557631..3558764 1 NC_002695.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3558764 914711 ECs3567 Escherichia coli O157:H7 str. Sakai nitric oxide reductase NP_311594.1 3557631 D 386585 CDS NP_311595.1 15832822 914710 complement(3558892..3561144) 1 NC_002695.1 similar to HYPF_ECOLI gi|2367152 (conserved in Escherichia coli K-12); transcriptional regulatory protein 3561144 914710 ECs3568 Escherichia coli O157:H7 str. Sakai transcriptional regulatory protein NP_311595.1 3558892 R 386585 CDS NP_311596.1 15832823 914709 complement(3561297..3561824) 1 NC_002695.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 3561824 914709 ECs3569 Escherichia coli O157:H7 str. Sakai electron transport protein HydN NP_311596.1 3561297 R 386585 CDS NP_311597.1 15832824 914708 complement(3561973..3562986) 1 NC_002695.1 similar to ASCG_ECOLI gi|1789068 (conserved in Escherichia coli K-12); ascBF operon repressor 3562986 914708 ECs3570 Escherichia coli O157:H7 str. Sakai ascBF operon repressor NP_311597.1 3561973 R 386585 CDS NP_311598.1 15832825 914707 3563243..3564700 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3564700 914707 ECs3571 Escherichia coli O157:H7 str. Sakai PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC NP_311598.1 3563243 D 386585 CDS NP_311599.1 15832826 914706 3564709..3566133 1 NC_002695.1 similar to ASCB_ECOLI gi|1789070 (conserved in Escherichia coli K-12); cryptic 6-phospho-beta-glucosidase 3566133 914706 ECs3572 Escherichia coli O157:H7 str. Sakai cryptic 6-phospho-beta-glucosidase NP_311599.1 3564709 D 386585 CDS NP_311600.1 15832827 914705 complement(3566257..3566727) 1 NC_002695.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3566727 hycI 914705 hycI Escherichia coli O157:H7 str. Sakai hydrogenase 3 maturation protease NP_311600.1 3566257 R 386585 CDS NP_311601.1 15832828 914704 complement(3566720..3567130) 1 NC_002695.1 similar to HYCH_ECOLI gi|1789073 (conserved in Escherichia coli K-12); formate hydrogenlyase maturation protein 3567130 914704 ECs3574 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase maturation protein NP_311601.1 3566720 R 386585 CDS NP_311602.1 15832829 914703 complement(3567127..3567894) 1 NC_002695.1 similar to HYCG_ECOLI gi|1789074 (conserved in Escherichia coli K-12); formate hydrogenlyase subunit-7 component G 3567894 914703 ECs3575 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase subunit-7 component G NP_311602.1 3567127 R 386585 CDS NP_311603.1 15832830 914702 complement(3567894..3568436) 1 NC_002695.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3568436 914702 ECs3576 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase complex iron-sulfur subunit NP_311603.1 3567894 R 386585 CDS NP_311604.1 15832831 914701 complement(3568446..3570155) 1 NC_002695.1 similar to HYCE_ECOLI gi|1789076 (conserved in Escherichia coli K-12); hydrogenase 3 large subunit 3570155 914701 ECs3577 Escherichia coli O157:H7 str. Sakai hydrogenase 3 large subunit NP_311604.1 3568446 R 386585 CDS NP_311605.1 15832832 914700 complement(3570173..3571096) 1 NC_002695.1 similar to HYCD_ECOLI gi|1789077 (conserved in Escherichia coli K-12); membrane-spanning protein of hydrogenase 3 3571096 914700 ECs3578 Escherichia coli O157:H7 str. Sakai membrane-spanning protein of hydrogenase 3 NP_311605.1 3570173 R 386585 CDS NP_311606.1 15832833 914699 complement(3571099..3572925) 1 NC_002695.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3572925 914699 ECs3579 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase subunit 3 NP_311606.1 3571099 R 386585 CDS NP_311607.1 15832834 914698 complement(3572922..3573533) 1 NC_002695.1 similar to HYCB_ECOLI gi|1789079 (conserved in Escherichia coli K-12); formate hydrogenlyase subunit-7 component B 3573533 914698 ECs3580 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase subunit-7 component B NP_311607.1 3572922 R 386585 CDS NP_311608.1 15832835 914697 complement(3573658..3574119) 1 NC_002695.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3574119 914697 ECs3581 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase regulatory protein HycA NP_311608.1 3573658 R 386585 CDS NP_311609.1 15832836 914696 3574331..3574681 1 NC_002695.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3574681 hypA 914696 hypA Escherichia coli O157:H7 str. Sakai hydrogenase nickel incorporation protein NP_311609.1 3574331 D 386585 CDS NP_311610.1 15832837 914695 3574685..3575557 1 NC_002695.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3575557 914695 ECs3583 Escherichia coli O157:H7 str. Sakai hydrogenase nickel incorporation protein HypB NP_311610.1 3574685 D 386585 CDS NP_311611.1 15832838 914694 3575548..3575820 1 NC_002695.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3575820 914694 ECs3584 Escherichia coli O157:H7 str. Sakai hydrogenase assembly chaperone NP_311611.1 3575548 D 386585 CDS NP_311612.1 15832839 914693 3575820..3576941 1 NC_002695.1 hydrogenase isoenzyme; similar to HYPD_ECOLI gi|1789084 (conserved in Escherichia coli K-12); hypothetical protein 3576941 914693 ECs3585 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311612.1 3575820 D 386585 CDS NP_311613.1 15832840 914692 3576980..3577948 1 NC_002695.1 similar to HYPE_ECOLI gi|1789085 (conserved in Escherichia coli K-12); hypothetical protein 3577948 914692 ECs3586 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311613.1 3576980 D 386585 CDS NP_311614.1 15832841 914691 3578022..3580100 1 NC_002695.1 similar to FHLA_ECOLI gi|1789087 (conserved in Escherichia coli K-12); formate hydrogenlyase transcriptional activator 3580100 914691 ECs3587 Escherichia coli O157:H7 str. Sakai formate hydrogenlyase transcriptional activator NP_311614.1 3578022 D 386585 CDS NP_311615.1 15832842 914690 complement(3580137..3580490) 1 NC_002695.1 similar to YGBA_ECOLI gi|1789088 (conserved in Escherichia coli K-12); hypothetical protein 3580490 914690 ECs3588 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311615.1 3580137 R 386585 CDS NP_311616.1 15832843 914689 3580777..3583338 1 NC_002695.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3583338 914689 ECs3589 Escherichia coli O157:H7 str. Sakai DNA mismatch repair protein MutS NP_311616.1 3580777 D 386585 CDS NP_311617.1 15832844 914688 3583444..3584100 1 NC_002695.1 similar to PPHB_ECOLI gi|1789090 (conserved in Escherichia coli K-12); serine/threonine-specific protein phosphatase 2 3584100 914688 ECs3590 Escherichia coli O157:H7 str. Sakai serine/threonine-specific protein phosphatase 2 NP_311617.1 3583444 D 386585 CDS NP_311618.1 15832845 914687 complement(3584141..3584377) 1 NC_002695.1 similar to hypothetical proteins e.g. VdcD [Streptomyces sp. D7] gi|4741970|gb|AAD28783.1|AF134589_3, YclD [Bacillus subtilis] gi|7452267|pir||A69762; hypothetical protein 3584377 914687 ECs3591 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311618.1 3584141 R 386585 CDS NP_311619.1 15832846 914686 complement(3584388..3585815) 1 NC_002695.1 similar to YclC [Escherichia coli O157:H7] gi|4887556|emb|CAB43499.1|, VdcC [Streptomyces sp. D7] gi|6686069|sp|Q9X697|VDCC_STRD7; 4-hydroxybenzoate decarboxylase 3585815 914686 ECs3592 Escherichia coli O157:H7 str. Sakai 4-hydroxybenzoate decarboxylase NP_311619.1 3584388 R 386585 CDS NP_311620.1 15832847 914685 complement(3585815..3586408) 1 NC_002695.1 similar to Pad1 [Escherichia coli O157:H7] gi|4887557|emb|CAB43500.1|, phenylacrylic acid decarboxylases e.g. VdcB [Streptomyces sp. D7]; phenylacrylic acid decarboxylase 3586408 914685 ECs3593 Escherichia coli O157:H7 str. Sakai phenylacrylic acid decarboxylase NP_311620.1 3585815 R 386585 CDS NP_311621.1 15832848 914684 3586555..3586962 1 NC_002695.1 similar to SlyA [Escherichia coli O157:H7] to gi|4887558|emb|CAB43501.1|, transcriptional regulators e.g. [Streptomyces coelicolor] gi|7481485|pir||T35022; MarR family transcriptional regulator 3586962 914684 ECs3594 Escherichia coli O157:H7 str. Sakai MarR family transcriptional regulator NP_311621.1 3586555 D 386585 CDS NP_311622.1 15832849 914683 complement(3587082..3588074) 1 NC_002695.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 3588074 914683 ECs3595 Escherichia coli O157:H7 str. Sakai RNA polymerase sigma factor RpoS NP_311622.1 3587082 R 386585 CDS NP_311623.1 15832850 914682 complement(3588137..3589276) 1 NC_002695.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; Nlp family transcriptional regulator 3589276 nlpD 914682 nlpD Escherichia coli O157:H7 str. Sakai Nlp family transcriptional regulator NP_311623.1 3588137 R 386585 CDS NP_311624.1 15832851 914681 complement(3589416..3590042) 1 NC_002695.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3590042 pcm 914681 pcm Escherichia coli O157:H7 str. Sakai protein-L-isoaspartate O-methyltransferase NP_311624.1 3589416 R 386585 CDS NP_311625.1 15832852 914680 complement(3590036..3590797) 1 NC_002695.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3590797 surE 914680 surE Escherichia coli O157:H7 str. Sakai stationary phase survival protein SurE NP_311625.1 3590036 R 386585 CDS NP_311626.1 15832853 914679 complement(3590778..3591827) 1 NC_002695.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3591827 truD 914679 truD Escherichia coli O157:H7 str. Sakai tRNA pseudouridine synthase D NP_311626.1 3590778 R 386585 CDS NP_311627.1 15832854 914678 complement(3591824..3592303) 1 NC_002695.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 3592303 ispF 914678 ispF Escherichia coli O157:H7 str. Sakai 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_311627.1 3591824 R 386585 CDS NP_311628.1 15832855 914677 complement(3592303..3593013) 1 NC_002695.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3593013 ispD 914677 ispD Escherichia coli O157:H7 str. Sakai 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_311628.1 3592303 R 386585 CDS NP_311629.1 15832856 914676 complement(3593032..3593343) 1 NC_002695.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3593343 ftsB 914676 ftsB Escherichia coli O157:H7 str. Sakai cell division protein FtsB NP_311629.1 3593032 R 386585 CDS NP_311630.1 15832857 914675 complement(3593537..3593860) 1 NC_002695.1 similar to YGBE_ECOLI gi|1789106 (conserved in Escherichia coli K-12); hypothetical protein 3593860 914675 ECs3603 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311630.1 3593537 R 386585 CDS NP_311631.1 15832858 914674 complement(3593910..3594515) 1 NC_002695.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3594515 914674 ECs3604 Escherichia coli O157:H7 str. Sakai adenylylsulfate kinase NP_311631.1 3593910 R 386585 CDS NP_311632.1 15832859 914673 complement(3594515..3595942) 1 NC_002695.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3595942 cysN 914673 cysN Escherichia coli O157:H7 str. Sakai sulfate adenylyltransferase subunit 1 NP_311632.1 3594515 R 386585 CDS NP_311633.1 15832860 914672 complement(3595944..3596852) 1 NC_002695.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3596852 914672 ECs3606 Escherichia coli O157:H7 str. Sakai sulfate adenylyltransferase subunit 2 NP_311633.1 3595944 R 386585 CDS NP_311634.1 15832861 914671 3597104..3598141 1 NC_002695.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3598141 914671 ECs3607 Escherichia coli O157:H7 str. Sakai alkaline phosphatase NP_311634.1 3597104 D 386585 CDS NP_311635.1 15832862 914670 complement(3598531..3598824) 1 NC_002695.1 similar to hypothetical protein [Escherichia coli] gi|7404494|sp|P45956|YGBF_ECOLI; hypothetical protein 3598824 914670 ECs3608 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311635.1 3598531 R 386585 CDS NP_311636.1 15832863 914669 complement(3598821..3599744) 1 NC_002695.1 similar to hypothetical protein b2755 [Escherichia coli strain K-12] gi|7460139|pir||G65056; hypothetical protein 3599744 914669 ECs3609 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311636.1 3598821 R 386585 CDS NP_311637.1 15832864 914668 complement(3599741..3600391) 1 NC_002695.1 similar to hypothetical protein b2756 [Escherichia coli strain K-12] gi|6136707|sp|Q46897|YGCH_ECOLI; hypothetical protein 3600391 914668 ECs3610 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311637.1 3599741 R 386585 CDS NP_311638.1 15832865 914667 complement(3600373..3601119) 1 NC_002695.1 similar to hypothetical protein b2757 [Escherichia coli strain K-12] gi|7459357|pir||A65057; hypothetical protein 3601119 914667 ECs3611 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311638.1 3600373 R 386585 CDS NP_311639.1 15832866 914666 complement(3601130..3602185) 1 NC_002695.1 similar to hypothetical protein b2758 [Escherichia coli strain K-12] gi|7476186|pir||C70849; hypothetical protein 3602185 914666 ECs3612 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311639.1 3601130 R 386585 CDS NP_311640.1 15832867 914665 complement(3602197..3602733) 1 NC_002695.1 hypothetical protein 3602733 914665 ECs3613 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311640.1 3602197 R 386585 CDS NP_311641.1 15832868 914664 complement(3602730..3604292) 1 NC_002695.1 similar to hypothetical protein b2760 [Escherichia coli strain K-12] gi|7451979|pir||D65057; hypothetical protein 3604292 914664 ECs3614 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311641.1 3602730 R 386585 CDS NP_311642.1 15832869 914663 complement(3604390..3607047) 1 NC_002695.1 similar to hypothetical protein YgcB [Escherichia coli strain K-12] gi|2506493|sp|P38036|YGCB_ECOLI; hypothetical protein 3607047 914663 ECs3615 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311642.1 3604390 R 386585 CDS NP_311643.1 15832870 914662 complement(3607281..3607433) 1 NC_002695.1 similar to YBDY_ECOLI gi|3025009|sp|P77091, SrnB [Plasmid F] dad|AP001918-5|BAA97875.1; hypothetical protein 3607433 914662 ECs3616 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311643.1 3607281 R 386585 CDS NP_311644.1 15832871 914661 complement(3607697..3608431) 1 NC_002695.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3608431 914661 ECs3617 Escherichia coli O157:H7 str. Sakai phosphoadenosine phosphosulfate reductase NP_311644.1 3607697 R 386585 CDS NP_311645.1 15832872 914660 complement(3608505..3610217) 1 NC_002695.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3610217 914660 ECs3618 Escherichia coli O157:H7 str. Sakai sulfite reductase subunit beta NP_311645.1 3608505 R 386585 CDS NP_311646.1 15832873 914659 complement(3610217..3612016) 1 NC_002695.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3612016 cysJ 914659 cysJ Escherichia coli O157:H7 str. Sakai sulfite reductase subunit alpha NP_311646.1 3610217 R 386585 CDS NP_311647.1 15832874 914658 3612332..3612697 1 NC_002695.1 similar to YGCM_ECOLI gi|1789124 (conserved in Escherichia coli K-12); 6-pyruvoyl tetrahydrobiopterin synthase 3612697 914658 ECs3620 Escherichia coli O157:H7 str. Sakai 6-pyruvoyl tetrahydrobiopterin synthase NP_311647.1 3612332 D 386585 CDS NP_311648.2 38704116 914657 3612775..3614046 1 NC_002695.1 similar to YGCN_ECOLI gi|1789125 (conserved in Escherichia coli K-12); hypothetical protein 3614046 914657 ECs3621 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311648.2 3612775 D 386585 CDS NP_311649.1 15832876 914656 3614001..3614297 1 NC_002695.1 similar to YGCO_ECOLI gi|1789126 (conserved in Escherichia coli K-12); hypothetical protein 3614297 914656 ECs3622 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311649.1 3614001 D 386585 CDS NP_311650.1 15832877 914655 3614314..3614889 1 NC_002695.1 similar to YGCP_ECOLI gi|1789127 (conserved in Escherichia coli K-12); anti-terminator regulatory protein 3614889 914655 ECs3623 Escherichia coli O157:H7 str. Sakai anti-terminator regulatory protein NP_311650.1 3614314 D 386585 CDS NP_311653.1 15832880 914651 complement(3615894..3616679) 1 NC_002695.1 similar to YGCR_ECOLI gi|2367158 (conserved in Escherichia coli K-12); transporter 3616679 914651 ECs3626 Escherichia coli O157:H7 str. Sakai transporter NP_311653.1 3615894 R 386585 CDS NP_311656.1 15832883 914648 complement(3618081..3619535) 1 NC_002695.1 similar to YGCU_ECOLI gi|2367159, B2772_ECOLI gi|1789131; hypothetical protein 3619535 914648 ECs3629 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311656.1 3618081 R 386585 CDS NP_311657.2 38704117 914647 complement(3619605..3620390) 1 NC_002695.1 similar to YGCW_ECOLI gi|1789135 (conserved in Escherichia coli K-12); oxidoreductase 3620390 914647 ECs3630 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311657.2 3619605 R 386585 CDS NP_311658.1 15832885 914646 3620709..3621986 1 NC_002695.1 similar to YQCE_ECOLI gi|2367161 (conserved in Escherichia coli K-12); transporter 3621986 914646 ECs3631 Escherichia coli O157:H7 str. Sakai transporter NP_311658.1 3620709 D 386585 CDS NP_311659.1 15832886 914645 3622013..3623491 1 NC_002695.1 similar to YGCE_ECOLI gi|1789138 (conserved in Escherichia coli K-12); kinase 3623491 914645 ECs3632 Escherichia coli O157:H7 str. Sakai kinase NP_311659.1 3622013 D 386585 CDS NP_311660.1 15832887 912281 complement(3624555..3625226) 1 NC_002695.1 similar to YGCF_ECOLI gi|1789139 (conserved in Escherichia coli K-12); hypothetical protein 3625226 912281 ECs3633 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311660.1 3624555 R 386585 CDS NP_311661.1 15832888 917122 3625606..3626001 1 NC_002695.1 similar to hypothetical proteins e.g. Tp70 [Treponema pallidum] gi|7521576|pir||A71309; hypothetical protein 3626001 917122 ECs3634 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311661.1 3625606 D 386585 CDS NP_311662.1 15832889 916569 3626015..3626689 1 NC_002695.1 similar to N-terminal parts of hypothetical proteins e.g. YgcG [Escherichia coli] gi|1723817|sp|P55140|YGCG_ECOLI; hypothetical protein 3626689 916569 ECs3635 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311662.1 3626015 D 386585 CDS NP_311664.1 15832891 916562 3626923..3628071 1 NC_002695.1 similar to hypothetical protein YgcG Escherichia coli P55140; hypothetical protein 3628071 916562 ECs3637 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311664.1 3626923 D 386585 CDS NP_311665.2 38704118 916561 3628077..3628982 1 NC_002695.1 similar to YGCG_ECOLI gi|1789140, hypothetical protein [Pseudomonas aeruginosa] dad|AE004490-5|AAG03925.1; hypothetical protein 3628982 916561 ECs3638 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311665.2 3628077 D 386585 CDS NP_311666.1 15832893 916564 complement(3629042..3630340) 1 NC_002695.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3630340 eno 916564 eno Escherichia coli O157:H7 str. Sakai phosphopyruvate hydratase NP_311666.1 3629042 R 386585 CDS NP_311667.1 15832894 914930 complement(3630428..3632065) 1 NC_002695.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3632065 pyrG 914930 pyrG Escherichia coli O157:H7 str. Sakai CTP synthetase NP_311667.1 3630428 R 386585 CDS NP_311668.1 15832895 916566 complement(3632293..3633084) 1 NC_002695.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 3633084 mazG 916566 mazG Escherichia coli O157:H7 str. Sakai nucleoside triphosphate pyrophosphohydrolase NP_311668.1 3632293 R 386585 CDS NP_311669.1 15832896 916551 complement(3633155..3633490) 1 NC_002695.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3633490 916551 ECs3642 Escherichia coli O157:H7 str. Sakai toxin ChpA NP_311669.1 3633155 R 386585 CDS NP_311670.1 15832897 916553 complement(3633490..3633738) 1 NC_002695.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3633738 916553 ECs3643 Escherichia coli O157:H7 str. Sakai antitoxin MazE NP_311670.1 3633490 R 386585 CDS NP_311671.1 15832898 916555 complement(3633816..3636050) 1 NC_002695.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3636050 relA 916555 relA Escherichia coli O157:H7 str. Sakai GDP/GTP pyrophosphokinase NP_311671.1 3633816 R 386585 CDS NP_311672.1 15832899 916557 complement(3636098..3637399) 1 NC_002695.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3637399 rumA 916557 rumA Escherichia coli O157:H7 str. Sakai 23S rRNA 5-methyluridine methyltransferase NP_311672.1 3636098 R 386585 CDS NP_311673.1 15832900 916559 3637456..3640212 1 NC_002695.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3640212 916559 ECs3646 Escherichia coli O157:H7 str. Sakai hybrid sensory histidine kinase BarA NP_311673.1 3637456 D 386585 CDS NP_311674.1 15832901 916552 complement(3640445..3641785) 1 NC_002695.1 similar to YGCX_ECOLI gi|1789150 (conserved in Escherichia coli K-12); glucarate dehydratase 3641785 916552 ECs3647 Escherichia coli O157:H7 str. Sakai glucarate dehydratase NP_311674.1 3640445 R 386585 CDS NP_311675.1 15832902 916543 complement(3641806..3642828) 1 NC_002695.1 similar to YGCY_ECOLI gi|1789151; glucarate dehydratase 3642828 916543 ECs3648 Escherichia coli O157:H7 str. Sakai glucarate dehydratase NP_311675.1 3641806 R 386585 CDS NP_311676.1 15832903 916547 complement(3643148..3644500) 1 NC_002695.1 similar to B2789_ECOLI gi|1789152 (conserved in Escherichia coli K-12); transporter 3644500 916547 ECs3649 Escherichia coli O157:H7 str. Sakai transporter NP_311676.1 3643148 R 386585 CDS NP_311677.1 15832904 916549 complement(3644935..3645384) 1 NC_002695.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3645384 916549 ECs3650 Escherichia coli O157:H7 str. Sakai flavodoxin NP_311677.1 3644935 R 386585 CDS NP_311678.1 15832905 916545 complement(3645402..3646184) 1 NC_002695.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3646184 916545 ECs3651 Escherichia coli O157:H7 str. Sakai tRNA pseudouridine synthase C NP_311678.1 3645402 R 386585 CDS NP_311679.1 15832906 916544 complement(3646184..3646513) 1 NC_002695.1 similar to B2792_ECOLI gi|1789156 (conserved in Escherichia coli K-12); hypothetical protein 3646513 916544 ECs3652 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311679.1 3646184 R 386585 CDS NP_311680.1 15832907 916531 complement(3647135..3647680) 1 NC_002695.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3647680 916531 ECs3653 Escherichia coli O157:H7 str. Sakai SecY interacting protein Syd NP_311680.1 3647135 R 386585 CDS NP_311681.1 15832908 916536 3647748..3648596 1 NC_002695.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3648596 queF 916536 queF Escherichia coli O157:H7 str. Sakai 7-cyano-7-deazaguanine reductase NP_311681.1 3647748 D 386585 CDS NP_311682.1 15832909 916540 3648708..3650072 1 NC_002695.1 similar to YGDH_ECOLI gi|1789159 (conserved in Escherichia coli K-12); hypothetical protein 3650072 916540 ECs3655 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311682.1 3648708 D 386585 CDS NP_311683.1 15832910 916539 3650629..3651918 1 NC_002695.1 similar to SDAC_ECOLI gi|1789160 (conserved in Escherichia coli K-12); serine transporter 3651918 916539 ECs3656 Escherichia coli O157:H7 str. Sakai serine transporter NP_311683.1 3650629 D 386585 CDS NP_311684.1 15832911 916537 3651976..3653343 1 NC_002695.1 similar to SDAA_ECOLI gi|1788116 (conserved in Escherichia coli K-12); L-serine dehydratase 3653343 916537 ECs3657 Escherichia coli O157:H7 str. Sakai L-serine dehydratase NP_311684.1 3651976 D 386585 CDS NP_311685.2 38704119 916535 3653455..3654210 1 NC_002695.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3654210 xni 916535 xni Escherichia coli O157:H7 str. Sakai exonuclease IX NP_311685.2 3653455 D 386585 CDS NP_311686.1 15832913 916534 complement(3654265..3655416) 1 NC_002695.1 similar to FUCO_ECOLI gi|1789163 (conserved in Escherichia coli K-12); L-1,2-propanediol oxidoreductase 3655416 916534 ECs3659 Escherichia coli O157:H7 str. Sakai L-1,2-propanediol oxidoreductase NP_311686.1 3654265 R 386585 CDS NP_311687.1 15832914 916460 complement(3655441..3656088) 1 NC_002695.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3656088 916460 ECs3660 Escherichia coli O157:H7 str. Sakai L-fuculose phosphate aldolase NP_311687.1 3655441 R 386585 CDS NP_311688.1 15832915 916474 3656635..3657951 1 NC_002695.1 similar to FUCP_ECOLI gi|1789166 (conserved in Escherichia coli K-12); L-fucose transporter 3657951 916474 ECs3661 Escherichia coli O157:H7 str. Sakai L-fucose transporter NP_311688.1 3656635 D 386585 CDS NP_311689.1 15832916 916477 3657984..3659759 1 NC_002695.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3659759 fucI 916477 fucI Escherichia coli O157:H7 str. Sakai L-fucose isomerase NP_311689.1 3657984 D 386585 CDS NP_311690.1 15832917 916532 3659838..3661286 1 NC_002695.1 similar to FUCK_ECOLI gi|1789168 (conserved in Escherichia coli K-12); L-fuculokinase 3661286 916532 ECs3663 Escherichia coli O157:H7 str. Sakai L-fuculokinase NP_311690.1 3659838 D 386585 CDS NP_311691.1 15832918 916530 3661288..3661710 1 NC_002695.1 similar to FUCU_ECOLI gi|1789169 (conserved in Escherichia coli K-12); FucU 3661710 916530 ECs3664 Escherichia coli O157:H7 str. Sakai FucU NP_311691.1 3661288 D 386585 CDS NP_311692.1 15832919 916529 3661768..3662499 1 NC_002695.1 regulates expression of genes involved in L-fucose utilization; FucR family transcriptional regulator 3662499 916529 ECs3665 Escherichia coli O157:H7 str. Sakai FucR family transcriptional regulator NP_311692.1 3661768 D 386585 CDS NP_311693.1 15832920 916522 complement(3662543..3663643) 1 NC_002695.1 similar to YGDE_ECOLI gi|1789171 (conserved in Escherichia coli K-12); RNA 2'-O-ribose methyltransferase 3663643 916522 ECs3666 Escherichia coli O157:H7 str. Sakai RNA 2'-O-ribose methyltransferase NP_311693.1 3662543 R 386585 CDS NP_311694.1 15832921 916523 complement(3663636..3664031) 1 NC_002695.1 similar to YGDD_ECOLI gi|1789172 (conserved in Escherichia coli K-12); hypothetical protein 3664031 916523 ECs3667 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311694.1 3663636 R 386585 CDS NP_311695.1 15832922 916524 complement(3664050..3664967) 1 NC_002695.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; GcvA family transcriptional regulator 3664967 916524 ECs3668 Escherichia coli O157:H7 str. Sakai GcvA family transcriptional regulator NP_311695.1 3664050 R 386585 CDS NP_311696.1 15832923 916528 complement(3665318..3665548) 1 NC_002695.1 similar to B2809_ECOLI gi|1789174 (conserved in Escherichia coli K-12); hypothetical protein 3665548 916528 ECs3669 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311696.1 3665318 R 386585 CDS NP_311697.1 15832924 916527 3665737..3666942 1 NC_002695.1 similar to B2810_ECOLI gi|1789175 (conserved in Escherichia coli K-12); cysteine sulfinate desulfinase 3666942 916527 ECs3670 Escherichia coli O157:H7 str. Sakai cysteine sulfinate desulfinase NP_311697.1 3665737 D 386585 CDS NP_311698.1 15832925 916526 3666942..3667385 1 NC_002695.1 similar to YGDK_ECOLI gi|1789176 (conserved in Escherichia coli K-12); hypothetical protein 3667385 916526 ECs3671 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311698.1 3666942 D 386585 CDS NP_311699.1 15832926 916509 complement(3667436..3668242) 1 NC_002695.1 similar to YGDL_ECOLI gi|1789177 (conserved in Escherichia coli K-12); hypothetical protein 3668242 916509 ECs3672 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311699.1 3667436 R 386585 CDS NP_311700.1 15832927 916516 complement(3668481..3669578) 1 NC_002695.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3669578 mltA 916516 mltA Escherichia coli O157:H7 str. Sakai murein transglycosylase A NP_311700.1 3668481 R 386585 CDS NP_311701.2 38704120 916515 complement(3670157..3671410) 1 NC_002695.1 similar to B2817_ECOLI gi|1789180 (conserved in Escherichia coli K-12); amidase 3671410 916515 ECs3674 Escherichia coli O157:H7 str. Sakai amidase NP_311701.2 3670157 R 386585 CDS NP_311702.1 15832929 916513 3671642..3672973 1 NC_002695.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3672973 916513 ECs3675 Escherichia coli O157:H7 str. Sakai N-acetylglutamate synthase NP_311702.1 3671642 D 386585 CDS NP_311703.1 15832930 916512 complement(3673035..3674861) 1 NC_002695.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3674861 recD 916512 recD Escherichia coli O157:H7 str. Sakai exonuclease V subunit alpha NP_311703.1 3673035 R 386585 CDS NP_311704.1 15832931 916511 complement(3674861..3678403) 1 NC_002695.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3678403 recB 916511 recB Escherichia coli O157:H7 str. Sakai exonuclease V subunit beta NP_311704.1 3674861 R 386585 CDS NP_311705.1 15832932 916510 complement(3678396..3681284) 1 NC_002695.1 similar to PTR_ECOLI gi|2367164 (conserved in Escherichia coli K-12); protease III 3681284 916510 ECs3678 Escherichia coli O157:H7 str. Sakai protease III NP_311705.1 3678396 R 386585 CDS NP_311706.1 15832933 916502 complement(3681460..3684828) 1 NC_002695.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3684828 recC 916502 recC Escherichia coli O157:H7 str. Sakai exonuclease V subunit gamma NP_311706.1 3681460 R 386585 CDS NP_311707.1 15832934 916503 complement(3684841..3685164) 1 NC_002695.1 similar to PPDC_ECOLI gi|1789187 (conserved in Escherichia coli K-12); hypothetical protein 3685164 916503 ECs3680 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311707.1 3684841 R 386585 CDS NP_311708.2 38704121 916506 complement(3685149..3685556) 1 NC_002695.1 similar to YGDB_ECOLI gi|1789188 (conserved in Escherichia coli K-12); hypothetical protein 3685556 916506 ECs3681 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311708.2 3685149 R 386585 CDS NP_311709.1 15832936 916507 complement(3685553..3686116) 1 NC_002695.1 similar to PPDB_ECOLI gi|1789189 (conserved in Escherichia coli K-12); hypothetical protein 3686116 916507 ECs3682 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311709.1 3685553 R 386585 CDS NP_311710.1 15832937 916504 complement(3686107..3686577) 1 NC_002695.1 similar to PPDA_ECOLI gi|1789190 (conserved in Escherichia coli K-12); hypothetical protein 3686577 916504 ECs3683 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311710.1 3686107 R 386585 CDS NP_311711.1 15832938 916501 complement(3686761..3687555) 1 NC_002695.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3687555 thyA 916501 thyA Escherichia coli O157:H7 str. Sakai thymidylate synthase NP_311711.1 3686761 R 386585 CDS NP_311712.1 15832939 916500 complement(3687562..3688437) 1 NC_002695.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3688437 916500 ECs3685 Escherichia coli O157:H7 str. Sakai prolipoprotein diacylglyceryl transferase NP_311712.1 3687562 R 386585 CDS NP_311713.1 15832940 916498 complement(3688588..3690834) 1 NC_002695.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3690834 916498 ECs3686 Escherichia coli O157:H7 str. Sakai fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain NP_311713.1 3688588 R 386585 CDS NP_311714.1 15832941 916489 complement(3690847..3691377) 1 NC_002695.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3691377 916489 ECs3687 Escherichia coli O157:H7 str. Sakai dinucleoside polyphosphate hydrolase NP_311714.1 3690847 R 386585 CDS NP_311715.1 15832942 916491 3692062..3692751 1 NC_002695.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3692751 916491 ECs3688 Escherichia coli O157:H7 str. Sakai DNA mismatch repair protein NP_311715.1 3692062 D 386585 CDS NP_311716.1 15832943 916496 3692820..3693533 1 NC_002695.1 similar to B2832_ECOLI gi|1789197 (conserved in Escherichia coli K-12); transporter 3693533 916496 ECs3689 Escherichia coli O157:H7 str. Sakai transporter NP_311716.1 3692820 D 386585 CDS NP_311717.1 15832944 916497 3693671..3693889 1 NC_002695.1 similar to B2833_ECOLI gi|1789198 (conserved in Escherichia coli K-12); hypothetical protein 3693889 916497 ECs3690 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311717.1 3693671 D 386585 CDS NP_311718.1 15832945 916495 3693997..3695037 1 NC_002695.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo/keto reductase 3695037 tas 916495 tas Escherichia coli O157:H7 str. Sakai aldo/keto reductase NP_311718.1 3693997 D 386585 CDS NP_311719.1 15832946 916494 complement(3695069..3696262) 1 NC_002695.1 similar to YGED_ECOLI gi|1789200 (conserved in Escherichia coli K-12); lysophospholipid transporter LplT 3696262 916494 ECs3692 Escherichia coli O157:H7 str. Sakai lysophospholipid transporter LplT NP_311719.1 3695069 R 386585 CDS NP_311720.1 15832947 916493 complement(3696255..3698414) 1 NC_002695.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-ACP synthetase/2-acylglycerophosphoethanolamine acyltransferase 3698414 916493 ECs3693 Escherichia coli O157:H7 str. Sakai bifunctional acyl-ACP synthetase/2-acylglycerophosphoethanolamine acyltransferase NP_311720.1 3696255 R 386585 CDS NP_311721.1 15832948 916490 3699000..3700031 1 NC_002695.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3700031 916490 ECs3694 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator GalR NP_311721.1 3699000 D 386585 CDS NP_311722.1 15832949 916478 complement(3700038..3701300) 1 NC_002695.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3701300 916478 ECs3695 Escherichia coli O157:H7 str. Sakai diaminopimelate decarboxylase NP_311722.1 3700038 R 386585 CDS NP_311723.1 15832950 916476 3701422..3702357 1 NC_002695.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 3702357 916476 ECs3696 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_311723.1 3701422 D 386585 CDS NP_311724.1 15832951 916475 complement(3702344..3703036) 1 NC_002695.1 similar to YGEA_ECOLI gi|1789205 (conserved in Escherichia coli K-12); racemase 3703036 916475 ECs3697 Escherichia coli O157:H7 str. Sakai racemase NP_311724.1 3702344 R 386585 CDS NP_311725.1 15832952 916479 complement(3703165..3704583) 1 NC_002695.1 similar to ARAE_ECOLI gi|1789207 (conserved in Escherichia coli K-12); low-affinity L-arabinose transport system proton symport protein 3704583 916479 ECs3698 Escherichia coli O157:H7 str. Sakai low-affinity L-arabinose transport system proton symport protein NP_311725.1 3703165 R 386585 CDS NP_311726.1 15832953 916482 complement(3704898..3705659) 1 NC_002695.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3705659 916482 ECs3699 Escherichia coli O157:H7 str. Sakai 2-deoxy-D-gluconate 3-dehydrogenase NP_311726.1 3704898 R 386585 CDS NP_311727.1 15832954 916485 complement(3705689..3706525) 1 NC_002695.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3706525 916485 ECs3700 Escherichia coli O157:H7 str. Sakai 5-keto-4-deoxyuronate isomerase NP_311727.1 3705689 R 386585 CDS NP_311728.2 162139761 916487 complement(3706812..3707993) 1 NC_002695.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3707993 916487 ECs3701 Escherichia coli O157:H7 str. Sakai acetyl-CoA acetyltransferase NP_311728.2 3706812 R 386585 CDS NP_311729.1 15832956 916486 3708248..3709477 1 NC_002695.1 similar to B2845_ECOLI gi|1789211 (conserved in Escherichia coli K-12); transporter protein 3709477 916486 ECs3702 Escherichia coli O157:H7 str. Sakai transporter protein NP_311729.1 3708248 D 386585 CDS NP_311730.1 15832957 916484 3709877..3710569 1 NC_002695.1 similar to YQEH_ECOLI gi|1789212 (conserved in Escherichia coli K-12); hypothetical protein 3710569 916484 ECs3703 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311730.1 3709877 D 386585 CDS NP_311731.1 15832958 916483 3710903..3711712 1 NC_002695.1 similar to YQEI_ECOLI gi|1789213 (conserved in Escherichia coli K-12); sensory transducer 3711712 916483 ECs3704 Escherichia coli O157:H7 str. Sakai sensory transducer NP_311731.1 3710903 D 386585 CDS NP_311732.1 15832959 916481 3711709..3712188 1 NC_002695.1 similar to YQEJ_ECOLI gi|2367166 (conserved in Escherichia coli K-12); hypothetical protein 3712188 916481 ECs3705 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311732.1 3711709 D 386585 CDS NP_311733.2 38704122 916480 complement(3712337..3712762) 1 NC_002695.1 similar to YQEK_ECOLI gi|2367167 (conserved in Escherichia coli K-12); hypothetical protein 3712762 916480 ECs3706 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311733.2 3712337 R 386585 CDS NP_311734.1 15832961 916473 3713192..3713683 1 NC_002695.1 similar to YGEF_ECOLI gi|2367169 (conserved in Escherichia coli K-12); hypothetical protein 3713683 916473 ECs3707 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311734.1 3713192 D 386585 CDS NP_311735.1 15832962 916472 3713909..3714400 1 NC_002695.1 similar to YGEG_ECOLI gi|1789215 (conserved in Escherichia coli K-12); hypothetical protein 3714400 916472 ECs3708 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311735.1 3713909 D 386585 CDS NP_311736.1 15832963 916471 3714734..3716110 1 NC_002695.1 similar to YGEH_ECOLI gi|1789216 (conserved in Escherichia coli K-12); transcriptional regulator 3716110 916471 ECs3709 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311736.1 3714734 D 386585 CDS NP_311737.1 15832964 916470 3716277..3716495 1 NC_002695.1 similar to B2853_ECOLI gi|1789217 (conserved in Escherichia coli K-12); hypothetical protein 3716495 916470 ECs3710 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311737.1 3716277 D 386585 CDS NP_311738.1 15832965 916469 3716682..3717083 1 NC_002695.1 similar to B2854_ECOLI gi|1789218 (conserved in Escherichia coli K-12); hypothetical protein 3717083 916469 ECs3711 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311738.1 3716682 D 386585 CDS NP_311739.1 15832966 916468 complement(3717102..3717734) 1 NC_002695.1 similar to b2856_ECOLI gi|1789220, YGEK_ECOLI gi|1789219; hypothetical protein 3717734 916468 ECs3712 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311739.1 3717102 R 386585 CDS NP_311740.1 15832967 916467 complement(3717957..3718388) 1 NC_002695.1 similar to B2857_ECOLI gi|1789221 (conserved in Escherichia coli K-12); hypothetical protein 3718388 916467 ECs3713 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311740.1 3717957 R 386585 CDS NP_311741.1 15832968 916466 complement(3718405..3718665) 1 NC_002695.1 similar to B2858_ECOLI gi|1789222 (conserved in Escherichia coli K-12); hypothetical protein 3718665 916466 ECs3714 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311741.1 3718405 R 386585 CDS NP_311742.1 15832969 916465 complement(3718607..3719188) 1 NC_002695.1 similar to B2859_ECOLI gi|1789223 (conserved in Escherichia coli K-12); hypothetical protein 3719188 916465 ECs3715 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311742.1 3718607 R 386585 CDS NP_311743.1 15832970 916464 complement(3719204..3719938) 1 NC_002695.1 lipoprotein precursor (type III secretion system); similar to lipoprotein precursors in type III secretion system e.g. PrgK protein [Salmonella typhimurium] gi|1172615|sp|P41786|PRGK_SALTY; type III secretion system lipoprotein precursor; EprK 3719938 916464 ECs3716 Escherichia coli O157:H7 str. Sakai EprK NP_311743.1 3719204 R 386585 CDS NP_311744.1 15832971 916459 complement(3719935..3720267) 1 NC_002695.1 similar to PrgJ [Salmonella typhimurium] gi|1172614|sp|P41785|PRGJ_SALTY, MxiI [Shigella flexneri] gi|547954|sp|Q06080|MXII_SHIFL; type III secretion protein; EprJ 3720267 916459 ECs3717 Escherichia coli O157:H7 str. Sakai EprJ NP_311744.1 3719935 R 386585 CDS NP_311745.1 15832972 916461 complement(3720287..3720526) 1 NC_002695.1 similar to type III secretion proteins e.g. PrgI protein [Salmonella typhimurium] gi|1172613|sp|P41784|PRGI_SALTY; EprI 3720526 916461 ECs3718 Escherichia coli O157:H7 str. Sakai EprI NP_311745.1 3720287 R 386585 CDS NP_311746.1 15832973 916462 complement(3720540..3721274) 1 NC_002695.1 similar to MxiG [Shigella flexneri] gi|2498603|sp|Q57332|MXIG_SHIFL, PrgH protein [Salmonella typhimurium] gi|1172612|sp|P41783|PRGH_SALTY; type III secretion protein; EprH 3721274 916462 ECs3719 Escherichia coli O157:H7 str. Sakai EprH NP_311746.1 3720540 R 386585 CDS NP_311747.1 15832974 916463 3721978..3722478 1 NC_002695.1 similar to transcriptional activator NtrC [Herbaspirillum seropedicae] gi|57313501|gb|AAC32391.21; transcriptional regulator 3722478 916463 ECs3720 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311747.1 3721978 D 386585 CDS NP_311748.1 15832975 916456 complement(3722835..3723956) 1 NC_002695.1 Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS 3723956 916456 ECs3721 Escherichia coli O157:H7 str. Sakai surface presentation of antigens protein SpaS NP_311748.1 3722835 R 386585 CDS NP_311751.1 15832978 916521 complement(3724734..3724994) 1 NC_002695.1 similar to type III secretion proteins e.g. SpaQ [Salmonella enterica] gi|975756|gb|AAC43847.1|; EpaQ 3724994 916521 ECs3724 Escherichia coli O157:H7 str. Sakai EpaQ NP_311751.1 3724734 R 386585 CDS NP_311752.1 15832979 916444 complement(3725005..3725670) 1 NC_002695.1 part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 3725670 spaP 916444 spaP Escherichia coli O157:H7 str. Sakai surface presentation of antigens protein SpaP NP_311752.1 3725005 R 386585 CDS NP_311753.1 15832980 916445 complement(3725660..3726646) 1 NC_002695.1 involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; surface presentation of antigens protein SpaO 3726646 916445 ECs3726 Escherichia coli O157:H7 str. Sakai surface presentation of antigens protein SpaO NP_311753.1 3725660 R 386585 CDS NP_311754.1 15832981 916452 complement(3726606..3727223) 1 NC_002695.1 similar to type III secretion proteins e.g. SpaN [Salmonella enterica] gi|1155289|gb|AAC44993.1; EivJ 3727223 916452 ECs3727 Escherichia coli O157:H7 str. Sakai EivJ NP_311754.1 3726606 R 386585 CDS NP_311755.1 15832982 916454 complement(3727248..3727481) 1 NC_002695.1 hypothetical protein 3727481 916454 ECs3728 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311755.1 3727248 R 386585 CDS NP_311756.1 15832983 916453 complement(3727459..3727794) 1 NC_002695.1 similar to type III secretion proteins e.g. SpaM [Salmonella enterica] gi|1155297|gb|AAC44998.1|; EivI 3727794 916453 ECs3729 Escherichia coli O157:H7 str. Sakai EivI NP_311756.1 3727459 R 386585 CDS NP_311757.1 15832984 916450 complement(3727907..3729226) 1 NC_002695.1 Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL 3729226 916450 ECs3730 Escherichia coli O157:H7 str. Sakai ATP synthase SpaL NP_311757.1 3727907 R 386585 CDS NP_311758.1 15832985 916449 complement(3729231..3731291) 1 NC_002695.1 similar to type III secretion proteins e.g. InvA [Salmonella typhimurium] gi|476819|pir||A42888; EivA 3731291 916449 ECs3731 Escherichia coli O157:H7 str. Sakai EivA NP_311758.1 3729231 R 386585 CDS NP_311759.1 15832986 916421 complement(3731284..3732429) 1 NC_002695.1 similar to type III secretion proteins e.g. invasion protein [Salmonella enterica] gi|1236845|gb|AAC45041.1|; EivE 3732429 916421 ECs3732 Escherichia coli O157:H7 str. Sakai EivE NP_311759.1 3731284 R 386585 CDS NP_311760.1 15832987 916419 complement(3732434..3734137) 1 NC_002695.1 similar to type III secretion proteins e.g. InvG [Salmonella typhimurium] gi|1170574|sp|P35672|INVG_SALTY; EivG 3734137 916419 ECs3733 Escherichia coli O157:H7 str. Sakai EivG NP_311760.1 3732434 R 386585 CDS NP_311761.1 15832988 916448 complement(3734134..3734883) 1 NC_002695.1 similar to transcriptional regulators e.g. invF [Salmonella typhimurium] gi|729852|sp|P39437|INVF_SALTY; transcriptional regulator of type III secretion system; type III secretion protein; EivF 3734883 916448 ECs3734 Escherichia coli O157:H7 str. Sakai EivF NP_311761.1 3734134 R 386585 CDS NP_311762.1 15832989 916447 complement(3735229..3735408) 1 NC_002695.1 hypothetical protein 3735408 916447 ECs3735 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311762.1 3735229 R 386585 CDS NP_311763.1 15832990 916438 complement(3735475..3736533) 1 NC_002695.1 similar to B2863 gi|1789227 and B2862_ECOLI gi|1789226; hypothetical protein 3736533 916438 ECs3736 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311763.1 3735475 R 386585 CDS NP_311764.1 15832991 916439 complement(3736517..3737122) 1 NC_002695.1 similar to B2863_ECOLI gi|1789227; hypothetical protein 3737122 916439 ECs3737 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311764.1 3736517 R 386585 CDS NP_311765.2 38704123 916442 complement(3737466..3738221) 1 NC_002695.1 similar to B2865_ECOLI gi|1789228 (conserved in Escherichia coli K-12); lipoprotein 3738221 916442 ECs3738 Escherichia coli O157:H7 str. Sakai lipoprotein NP_311765.2 3737466 R 386585 CDS NP_311766.1 15832993 916443 3738676..3740934 1 NC_002695.1 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3740934 916443 ECs3739 Escherichia coli O157:H7 str. Sakai xanthine dehydrogenase subunit XdhA NP_311766.1 3738676 D 386585 CDS NP_311767.1 15832994 916440 3740945..3741823 1 NC_002695.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3741823 916440 ECs3740 Escherichia coli O157:H7 str. Sakai xanthine dehydrogenase subunit XdhB NP_311767.1 3740945 D 386585 CDS NP_311768.1 15832995 916430 3741820..3742299 1 NC_002695.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3742299 916430 ECs3741 Escherichia coli O157:H7 str. Sakai xanthine dehydrogenase subunit XdhC NP_311768.1 3741820 D 386585 CDS NP_311769.1 15832996 916432 complement(3742339..3744117) 1 NC_002695.1 similar to YGEV_ECOLI gi|1789233 (conserved in Escherichia coli K-12); transcriptional regulator 3744117 916432 ECs3742 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311769.1 3742339 R 386585 CDS NP_311770.1 15832997 916433 3744593..3745783 1 NC_002695.1 catalyzes the formation of L-citruline from L-ornithine and carbamoylphosphate; aspartate/ornithine carbamoyltransferase 3745783 916433 ECs3743 Escherichia coli O157:H7 str. Sakai aspartate/ornithine carbamoyltransferase NP_311770.1 3744593 D 386585 CDS NP_311771.1 15832998 916434 3745841..3747037 1 NC_002695.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3747037 916434 ECs3744 Escherichia coli O157:H7 str. Sakai diaminopropionate ammonia-lyase NP_311771.1 3745841 D 386585 CDS NP_311772.1 15832999 916436 3747095..3748306 1 NC_002695.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3748306 916436 ECs3745 Escherichia coli O157:H7 str. Sakai peptidase NP_311772.1 3747095 D 386585 CDS NP_311773.2 38704124 916437 3748359..3749744 1 NC_002695.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3749744 916437 ECs3746 Escherichia coli O157:H7 str. Sakai phenylhydantoinase NP_311773.2 3748359 D 386585 CDS NP_311774.1 15833001 916431 3749792..3750724 1 NC_002695.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3750724 916431 ECs3747 Escherichia coli O157:H7 str. Sakai carbamate kinase NP_311774.1 3749792 D 386585 CDS NP_311775.1 15833002 916429 complement(3750765..3752390) 1 NC_002695.1 similar to B2875_ECOLI gi|1789240 (conserved in Escherichia coli K-12); synthase 3752390 916429 ECs3748 Escherichia coli O157:H7 str. Sakai synthase NP_311775.1 3750765 R 386585 CDS NP_311776.1 15833003 916423 complement(3752438..3753145) 1 NC_002695.1 similar to B2876_ECOLI gi|1789241 (conserved in Escherichia coli K-12); hypothetical protein 3753145 916423 ECs3749 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311776.1 3752438 R 386585 CDS NP_311777.1 15833004 916424 3753311..3753889 1 NC_002695.1 similar to YGFJ_ECOLI gi|1789242 (conserved in Escherichia coli K-12); hypothetical protein 3753889 916424 ECs3750 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311777.1 3753311 D 386585 CDS NP_311778.1 15833005 916425 3754211..3757309 1 NC_002695.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3757309 916425 ECs3751 Escherichia coli O157:H7 str. Sakai selenate reductase subunit YgfK NP_311778.1 3754211 D 386585 CDS NP_311779.1 15833006 916426 3757312..3758640 1 NC_002695.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3758640 916426 ECs3752 Escherichia coli O157:H7 str. Sakai chlorohydrolase/aminohydrolase NP_311779.1 3757312 D 386585 CDS NP_311780.1 15833007 916427 3758690..3759469 1 NC_002695.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3759469 916427 ECs3753 Escherichia coli O157:H7 str. Sakai selenate reductase subunit YgfM NP_311780.1 3758690 D 386585 CDS NP_311781.1 15833008 916428 3759466..3762336 1 NC_002695.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3762336 916428 ECs3754 Escherichia coli O157:H7 str. Sakai selenate reductase subunit YgfN NP_311781.1 3759466 D 386585 CDS NP_311782.1 15833009 916416 3762444..3763901 1 NC_002695.1 similar to YGFO_ECOLI gi|1789248 (conserved in Escherichia coli K-12); transporter 3763901 916416 ECs3755 Escherichia coli O157:H7 str. Sakai transporter NP_311782.1 3762444 D 386585 CDS NP_311783.1 15833010 916417 3763916..3765235 1 NC_002695.1 Catalyzes the deamination of guanine; guanine deaminase 3765235 916417 ECs3756 Escherichia coli O157:H7 str. Sakai guanine deaminase NP_311783.1 3763916 D 386585 CDS NP_311784.1 15833011 916418 3765271..3766638 1 NC_002695.1 similar to YGFQ_ECOLI gi|1789250, YGFR_ECOLI gi|1789251; oxidoreductase 3766638 916418 ECs3757 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311784.1 3765271 D 386585 CDS NP_311785.1 15833012 916420 complement(3766674..3767069) 1 NC_002695.1 similar to YGFS_ECOLI gi|1789252; oxidoreductase Fe-S subunit 3767069 916420 ECs3758 Escherichia coli O157:H7 str. Sakai oxidoreductase Fe-S subunit NP_311785.1 3766674 R 386585 CDS NP_311786.1 15833013 916422 complement(3767162..3769096) 1 NC_002695.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3769096 916422 ECs3759 Escherichia coli O157:H7 str. Sakai oxidoreductase Fe-S binding subunit NP_311786.1 3767162 R 386585 CDS NP_311787.1 15833014 916405 3769448..3770965 1 NC_002695.1 similar to YGFU_ECOLI gi|1789254 (conserved in Escherichia coli K-12); permease 3770965 916405 ECs3760 Escherichia coli O157:H7 str. Sakai permease NP_311787.1 3769448 D 386585 CDS NP_311788.1 15833015 916410 3771215..3771763 1 NC_002695.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3771763 916410 ECs3761 Escherichia coli O157:H7 str. Sakai isopentenyl-diphosphate delta-isomerase NP_311788.1 3771215 D 386585 CDS NP_311789.1 15833016 916412 complement(3771806..3773323) 1 NC_002695.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3773323 lysS 916412 lysS Escherichia coli O157:H7 str. Sakai lysyl-tRNA synthetase NP_311789.1 3771806 R 386585 CDS NP_311790.1 15833017 916415 complement(join(3773333..3774355,3774357..3774431)) 1 NC_002695.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3774431 prfB 916415 prfB Escherichia coli O157:H7 str. Sakai peptide chain release factor 2 NP_311790.1 3773333 R 386585 CDS NP_311791.1 15833018 916414 complement(3774522..3776255) 1 NC_002695.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3776255 916414 ECs3764 Escherichia coli O157:H7 str. Sakai ssDNA exonuclease RecJ NP_311791.1 3774522 R 386585 CDS NP_311792.1 15833019 916411 complement(3776261..3776971) 1 NC_002695.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3776971 916411 ECs3765 Escherichia coli O157:H7 str. Sakai thiol:disulfide interchange protein DsbC NP_311792.1 3776261 R 386585 CDS NP_311793.1 15833020 912431 complement(3776996..3777892) 1 NC_002695.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3777892 xerD 912431 xerD Escherichia coli O157:H7 str. Sakai site-specific tyrosine recombinase XerD NP_311793.1 3776996 R 386585 CDS NP_311794.1 15833021 913012 3778004..3778525 1 NC_002695.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3778525 913012 ECs3767 Escherichia coli O157:H7 str. Sakai flavodoxin FldB NP_311794.1 3778004 D 386585 CDS NP_311795.1 15833022 916350 complement(3778565..3778972) 1 NC_002695.1 similar to B2896_ECOLI gi|1789263 (conserved in Escherichia coli K-12); hypothetical protein 3778972 916350 ECs3768 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311795.1 3778565 R 386585 CDS NP_311796.1 15833023 916353 complement(3778953..3779219) 1 NC_002695.1 similar to YGFY_ECOLI gi|1789264 (conserved in Escherichia coli K-12); hypothetical protein 3779219 916353 ECs3769 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311796.1 3778953 R 386585 CDS NP_311797.1 15833024 916392 3779462..3780442 1 NC_002695.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3780442 916392 ECs3770 Escherichia coli O157:H7 str. Sakai global regulator NP_311797.1 3779462 D 386585 CDS NP_311798.1 15833025 916413 complement(3780519..3781178) 1 NC_002695.1 similar to B2899_ECOLI gi|1789266 (conserved in Escherichia coli K-12); oxidoreductase 3781178 916413 ECs3771 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311798.1 3780519 R 386585 CDS NP_311799.1 15833026 916409 complement(3781342..3781653) 1 NC_002695.1 similar to YQFB_ECOLI gi|1789267 (conserved in Escherichia coli K-12); hypothetical protein 3781653 916409 ECs3772 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311799.1 3781342 R 386585 CDS NP_311800.1 15833027 916408 3781692..3783131 1 NC_002695.1 similar to BGLA_ECOLI gi|2367174 (conserved in Escherichia coli K-12); 6-phospho-beta-glucosidase 3783131 916408 ECs3773 Escherichia coli O157:H7 str. Sakai 6-phospho-beta-glucosidase NP_311800.1 3781692 D 386585 CDS NP_311801.1 15833028 916407 complement(3783297..3786170) 1 NC_002695.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3786170 916407 ECs3774 Escherichia coli O157:H7 str. Sakai glycine dehydrogenase NP_311801.1 3783297 R 386585 CDS NP_311802.1 15833029 916406 complement(3786288..3786677) 1 NC_002695.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3786677 916406 ECs3775 Escherichia coli O157:H7 str. Sakai glycine cleavage system protein H NP_311802.1 3786288 R 386585 CDS NP_311803.1 15833030 916404 complement(3786701..3787795) 1 NC_002695.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3787795 gcvT 916404 gcvT Escherichia coli O157:H7 str. Sakai glycine cleavage system aminomethyltransferase T NP_311803.1 3786701 R 386585 CDS NP_311804.1 15833031 916403 complement(3788243..3789445) 1 NC_002695.1 similar to VISC_ECOLI gi|1789273 (conserved in Escherichia coli K-12); hypothetical protein 3789445 916403 ECs3777 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311804.1 3788243 R 386585 CDS NP_311805.1 15833032 916402 complement(3789469..3790647) 1 NC_002695.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3790647 916402 ECs3778 Escherichia coli O157:H7 str. Sakai 2-octaprenyl-6-methoxyphenyl hydroxylase NP_311805.1 3789469 R 386585 CDS NP_311806.1 15833033 916398 complement(3790644..3791969) 1 NC_002695.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3791969 916398 ECs3779 Escherichia coli O157:H7 str. Sakai proline aminopeptidase P II NP_311806.1 3790644 R 386585 CDS NP_311807.3 162139720 916399 complement(3791995..3792573) 1 NC_002695.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3792573 916399 ECs3780 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311807.3 3791995 R 386585 CDS NP_311808.1 15833035 916400 3792741..3793070 1 NC_002695.1 similar to YGFE_ECOLI gi|1789277 (conserved in Escherichia coli K-12); Z-ring-associated protein 3793070 916400 ECs3781 Escherichia coli O157:H7 str. Sakai Z-ring-associated protein NP_311808.1 3792741 D 386585 CDS NP_311809.3 229544776 916397 3793370..3793918 1 NC_002695.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3793918 916397 ECs3782 Escherichia coli O157:H7 str. Sakai ligase NP_311809.3 3793370 D 386585 CDS NP_311810.1 15833037 916396 complement(3794091..3794321) 1 NC_002695.1 hypothetical protein 3794321 916396 ECs3783 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311810.1 3794091 R 386585 CDS NP_311811.1 15833038 916388 complement(3794700..3795932) 1 NC_002695.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3795932 916388 ECs3784 Escherichia coli O157:H7 str. Sakai D-3-phosphoglycerate dehydrogenase NP_311811.1 3794700 R 386585 CDS NP_311812.1 15833039 916389 complement(3796187..3796846) 1 NC_002695.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3796846 916389 ECs3785 Escherichia coli O157:H7 str. Sakai ribose-5-phosphate isomerase A NP_311812.1 3796187 R 386585 CDS NP_311813.1 15833040 916391 3797229..3798122 1 NC_002695.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3798122 916391 ECs3786 Escherichia coli O157:H7 str. Sakai chromosome replication initiation inhibitor protein NP_311813.1 3797229 D 386585 CDS NP_311814.1 15833041 916393 3798326..3800470 1 NC_002695.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3800470 916393 ECs3787 Escherichia coli O157:H7 str. Sakai methylmalonyl-CoA mutase NP_311814.1 3798326 D 386585 CDS NP_311815.1 15833042 916395 3800463..3801458 1 NC_002695.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3801458 916395 ECs3788 Escherichia coli O157:H7 str. Sakai arginine/ornithine transport system ATPase NP_311815.1 3800463 D 386585 CDS NP_311816.2 38704127 916394 3801469..3802254 1 NC_002695.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3802254 916394 ECs3789 Escherichia coli O157:H7 str. Sakai methylmalonyl-CoA decarboxylase NP_311816.2 3801469 D 386585 CDS NP_311817.1 15833044 916546 3802278..3803756 1 NC_002695.1 similar to YGFH_ECOLI gi|1789287 (conserved in Escherichia coli K-12); coenzyme A transferase 3803756 916546 ECs3790 Escherichia coli O157:H7 str. Sakai coenzyme A transferase NP_311817.1 3802278 D 386585 CDS NP_311820.1 15833047 916387 complement(3804816..3805556) 1 NC_002695.1 similar to YGGE_ECOLI gi|1789289 (conserved in Escherichia coli K-12); hypothetical protein 3805556 916387 ECs3793 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311820.1 3804816 R 386585 CDS NP_311821.1 15833048 916374 complement(3805649..3806284) 1 NC_002695.1 Involved in the export of arginine; arginine exporter protein 3806284 916374 ECs3794 Escherichia coli O157:H7 str. Sakai arginine exporter protein NP_311821.1 3805649 R 386585 CDS NP_311822.1 15833049 916375 complement(3806423..3807283) 1 NC_002695.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3807283 916375 ECs3795 Escherichia coli O157:H7 str. Sakai mechanosensitive channel MscS NP_311822.1 3806423 R 386585 CDS NP_311823.1 15833050 916381 complement(3807641..3808720) 1 NC_002695.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3808720 916381 ECs3796 Escherichia coli O157:H7 str. Sakai fructose-bisphosphate aldolase NP_311823.1 3807641 R 386585 CDS NP_311824.1 15833051 916382 complement(3808935..3810098) 1 NC_002695.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3810098 pgk 916382 pgk Escherichia coli O157:H7 str. Sakai phosphoglycerate kinase NP_311824.1 3808935 R 386585 CDS NP_311825.1 15833052 916383 complement(3810148..3811167) 1 NC_002695.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3811167 916383 ECs3798 Escherichia coli O157:H7 str. Sakai erythrose 4-phosphate dehydrogenase NP_311825.1 3810148 R 386585 CDS NP_311826.1 15833053 916385 3811539..3811970 1 NC_002695.1 similar to hypothetical protein [Methanobacterium thermoautotrophicum] gi|7482365|pir||D69031; hypothetical protein 3811970 916385 ECs3799 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311826.1 3811539 D 386585 CDS NP_311827.1 15833054 916384 3811993..3812571 1 NC_002695.1 similar to probable low-affinity inorganic phosphate transporter [Mycobacterium tuberculosis] gi|7387993|sp|O06411|PIT_MYCTU, hypothetical protein [Plasmid pNZ4000] gi|5123516|gb|AAD40355.1|; transporter 3812571 916384 ECs3800 Escherichia coli O157:H7 str. Sakai transporter NP_311827.1 3811993 D 386585 CDS NP_311828.1 15833055 916380 3812572..3813279 1 NC_002695.1 similar to hypothetical protein [Plasmid pNZ4000] gi|5123517|gb|AAD40356.1|; lipoprotein 3813279 916380 ECs3801 Escherichia coli O157:H7 str. Sakai lipoprotein NP_311828.1 3812572 D 386585 CDS NP_311829.1 15833056 916379 3813267..3813944 1 NC_002695.1 similar to ABC transporter ATP-binding proteins e.g. cation ABC transporter (ATP-binding protein) homolog ykoD [Bacillus subtilis] gi|7445788|pir||H69858; ABC transporter ATP-binding protein 3813944 916379 ECs3802 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311829.1 3813267 D 386585 CDS NP_311830.1 15833057 916378 3813938..3814615 1 NC_002695.1 similar to ABC transporter ATP-binding proteins e.g. PotA homolog [Agrobacterium rhizogenes plasmid pRi1724] gi|8918682|dbj|BAA97747.1|, [plasmid pNZ4000] gi|512351; ABC transporter ATP-binding protein 3814615 916378 ECs3803 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_311830.1 3813938 D 386585 CDS NP_311831.1 15833058 916377 complement(3814587..3815300) 1 NC_002695.1 similar to YGGC_ECOLI gi|1789296, kinase-like protein FrcK [Sinorhizobium meliloti] dad|AF196574-5|AAG28501.1; fructose transport system kinase 3815300 frcK 916377 frcK Escherichia coli O157:H7 str. Sakai fructose transport system kinase NP_311831.1 3814587 R 386585 CDS NP_311832.1 15833059 916376 complement(3815297..3815806) 1 NC_002695.1 similar to YGGD_ECOLI gi|1789297 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 3815806 916376 ECs3805 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_311832.1 3815297 R 386585 CDS NP_311833.1 15833060 916370 complement(3815828..3816793) 1 NC_002695.1 similar to YGGF_ECOLI gi|1789298 (conserved in Escherichia coli K-12); fructose-1,6-bisphosphatase II-like protein 3816793 916370 ECs3806 Escherichia coli O157:H7 str. Sakai fructose-1,6-bisphosphatase II-like protein NP_311833.1 3815828 R 386585 CDS NP_311834.1 15833061 916371 complement(3816790..3818067) 1 NC_002695.1 similar to YGGP_ECOLI gi|1789300, B2931_ECOLI similar to gi|1789299; oxidoreductase 3818067 916371 ECs3807 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311834.1 3816790 R 386585 CDS NP_311835.1 15833062 916373 complement(3818082..3819470) 1 NC_002695.1 similar to CMTA_ECOLI gi|1789301 (conserved in Escherichia coli K-12); mannitol-specific PTS system enzyme II component 3819470 916373 ECs3808 Escherichia coli O157:H7 str. Sakai mannitol-specific PTS system enzyme II component NP_311835.1 3818082 R 386585 CDS NP_311836.1 15833063 916372 complement(3819498..3819941) 1 NC_002695.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA 3819941 cmtB 916372 cmtB Escherichia coli O157:H7 str. Sakai mannitol phosphotransferase subunit EIIA NP_311836.1 3819498 R 386585 CDS NP_311837.1 15833064 916368 complement(3820255..3822246) 1 NC_002695.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3822246 916368 ECs3810 Escherichia coli O157:H7 str. Sakai transketolase NP_311837.1 3820255 R 386585 CDS NP_311838.2 38704128 916362 3822524..3823282 1 NC_002695.1 similar to YGGG_ECOLI gi|1789305 (conserved in Escherichia coli K-12); hypothetical protein 3823282 916362 ECs3811 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311838.2 3822524 D 386585 CDS NP_311839.1 15833066 916365 complement(3823488..3824408) 1 NC_002695.1 catalyzes the formation of putrescine from agmatine; agmatinase 3824408 916365 ECs3812 Escherichia coli O157:H7 str. Sakai agmatinase NP_311839.1 3823488 R 386585 CDS NP_311840.1 15833067 916367 complement(3824544..3825275) 1 NC_002695.1 lipoprotein 3825275 916367 ECs3813 Escherichia coli O157:H7 str. Sakai lipoprotein NP_311840.1 3824544 R 386585 CDS NP_311841.1 15833068 916366 complement(3825421..3827397) 1 NC_002695.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3827397 916366 ECs3814 Escherichia coli O157:H7 str. Sakai arginine decarboxylase NP_311841.1 3825421 R 386585 CDS NP_311842.1 15833069 916363 complement(3827406..3827552) 1 NC_002695.1 similar to YQGB_ECOLI gi|1789308 (conserved in Escherichia coli K-12); hypothetical protein 3827552 916363 ECs3815 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311842.1 3827406 R 386585 CDS NP_311843.1 15833070 916361 3827673..3827888 1 NC_002695.1 similar to YQGC_ECOLI gi|1789309 (conserved in Escherichia coli K-12); hypothetical protein 3827888 916361 ECs3816 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311843.1 3827673 D 386585 CDS NP_311844.1 15833071 916369 complement(3827885..3828136) 1 NC_002695.1 similar to YQGD_ECOLI gi|1789310 (conserved in Escherichia coli K-12); hypothetical protein 3828136 916369 ECs3817 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311844.1 3827885 R 386585 CDS NP_311845.1 15833072 916356 3828192..3829346 1 NC_002695.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3829346 916356 ECs3818 Escherichia coli O157:H7 str. Sakai S-adenosylmethionine synthetase NP_311845.1 3828192 D 386585 CDS NP_311846.1 15833073 916357 3829783..3831177 1 NC_002695.1 similar to GALP_ECOLI gi|1789312 (conserved in Escherichia coli K-12); galactose-proton symport of transport system 3831177 916357 ECs3819 Escherichia coli O157:H7 str. Sakai galactose-proton symport of transport system NP_311846.1 3829783 D 386585 CDS NP_311847.1 15833074 916358 3831254..3831751 1 NC_002695.1 similar to SPRT_ECOLI gi|1789313 (conserved in Escherichia coli K-12); hypothetical protein 3831751 916358 ECs3820 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311847.1 3831254 D 386585 CDS NP_311848.1 15833075 916360 3831846..3832553 1 NC_002695.1 similar to ENDA_ECOLI gi|1789314 (conserved in Escherichia coli K-12); DNA-specific endonuclease I 3832553 916360 ECs3821 Escherichia coli O157:H7 str. Sakai DNA-specific endonuclease I NP_311848.1 3831846 D 386585 CDS NP_311849.2 38704129 916359 3832633..3833364 1 NC_002695.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3833364 916359 ECs3822 Escherichia coli O157:H7 str. Sakai 16S ribosomal RNA methyltransferase RsmE NP_311849.2 3832633 D 386585 CDS NP_311850.1 15833077 916355 3833377..3834324 1 NC_002695.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3834324 916355 ECs3823 Escherichia coli O157:H7 str. Sakai glutathione synthetase NP_311850.1 3833377 D 386585 CDS NP_311851.2 38704130 916451 3834436..3834999 1 NC_002695.1 similar to YQGE_ECOLI gi|1789317 (conserved in Escherichia coli K-12); hypothetical protein 3834999 916451 ECs3824 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311851.2 3834436 D 386585 CDS NP_311852.1 15833079 916455 3834999..3835415 1 NC_002695.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3835415 916455 ECs3825 Escherichia coli O157:H7 str. Sakai Holliday junction resolvase-like protein NP_311852.1 3834999 D 386585 CDS NP_311853.1 15833080 916354 complement(3835606..3836631) 1 NC_002695.1 similar to YGGR_ECOLI gi|1789320 (conserved in Escherichia coli K-12); protein transport 3836631 916354 ECs3827 Escherichia coli O157:H7 str. Sakai protein transport NP_311853.1 3835606 R 386585 CDS NP_311854.1 15833081 916352 3836604..3837308 1 NC_002695.1 similar to YGGS_ECOLI gi|1789321 (conserved in Escherichia coli K-12); hypothetical protein 3837308 916352 ECs3826 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311854.1 3836604 D 386585 CDS NP_311855.1 15833082 916342 3837326..3837892 1 NC_002695.1 similar to YGGT_ECOLI gi|1789322 (conserved in Escherichia coli K-12); resistance protein 3837892 916342 ECs3828 Escherichia coli O157:H7 str. Sakai resistance protein NP_311855.1 3837326 D 386585 CDS NP_311856.2 162139760 916346 3837889..3838179 1 NC_002695.1 similar to YGGU_ECOLI gi|1789323 (conserved in Escherichia coli K-12); hypothetical protein 3838179 916346 ECs3829 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311856.2 3837889 D 386585 CDS NP_311857.1 15833084 916347 3838187..3838780 1 NC_002695.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3838780 916347 ECs3830 Escherichia coli O157:H7 str. Sakai deoxyribonucleotide triphosphate pyrophosphatase NP_311857.1 3838187 D 386585 CDS NP_311858.1 15833085 916351 3838773..3839909 1 NC_002695.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3839909 916351 ECs3831 Escherichia coli O157:H7 str. Sakai coproporphyrinogen III oxidase NP_311858.1 3838773 D 386585 CDS NP_311859.1 15833086 912996 complement(3840152..3841159) 1 NC_002695.1 similar to YGGM_ECOLI gi|1789326 (conserved in Escherichia coli K-12); hypothetical protein 3841159 912996 ECs3832 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311859.1 3840152 R 386585 CDS NP_311860.1 15833087 916327 complement(3841276..3842322) 1 NC_002695.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3842322 ansB 916327 ansB Escherichia coli O157:H7 str. Sakai L-asparaginase II NP_311860.1 3841276 R 386585 CDS NP_311861.1 15833088 916337 complement(3842498..3843217) 1 NC_002695.1 similar to YGGN_ECOLI gi|1789328 (conserved in Escherichia coli K-12); hypothetical protein 3843217 916337 ECs3834 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311861.1 3842498 R 386585 CDS NP_311862.2 38704131 916340 complement(3843401..3843727) 1 NC_002695.1 similar to YGGL_ECOLI gi|1789329 (conserved in Escherichia coli K-12); hypothetical protein 3843727 916340 ECs3835 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311862.2 3843401 R 386585 CDS NP_311863.1 15833090 916348 complement(3843727..3844446) 1 NC_002695.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3844446 trmB 916348 trmB Escherichia coli O157:H7 str. Sakai tRNA (guanine-N(7)-)-methyltransferase NP_311863.1 3843727 R 386585 CDS NP_311864.1 15833091 916345 3844607..3845659 1 NC_002695.1 similar to MUTY_ECOLI gi|1789331 (conserved in Escherichia coli K-12); adenine DNA glycosylase 3845659 916345 ECs3837 Escherichia coli O157:H7 str. Sakai adenine DNA glycosylase NP_311864.1 3844607 D 386585 CDS NP_311865.1 15833092 916344 3845687..3845962 1 NC_002695.1 similar to YGGX_ECOLI gi|1789332 (conserved in Escherichia coli K-12); hypothetical protein 3845962 916344 ECs3838 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311865.1 3845687 D 386585 CDS NP_311866.1 15833093 916343 3846024..3847106 1 NC_002695.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3847106 mltC 916343 mltC Escherichia coli O157:H7 str. Sakai murein transglycosylase C NP_311866.1 3846024 D 386585 CDS NP_311867.2 38704132 916341 3847308..3848564 1 NC_002695.1 transport of nucleosides; permease; similar to NUPG_ECOLI gi|1789336 (conserved in Escherichia coli K-12); protein NupG 3848564 916341 ECs3840 Escherichia coli O157:H7 str. Sakai protein NupG NP_311867.2 3847308 D 386585 CDS NP_311868.2 38704133 916339 complement(3848614..3850749) 1 NC_002695.1 similar to SPEC_ECOLI gi|1789337 (conserved in Escherichia coli K-12); ornithine decarboxylase 3850749 916339 ECs3841 Escherichia coli O157:H7 str. Sakai ornithine decarboxylase NP_311868.2 3848614 R 386585 CDS NP_311869.1 15833096 916333 3851147..3851854 1 NC_002695.1 similar to YQGA_ECOLI gi|1789338 (conserved in Escherichia coli K-12); transporter 3851854 916333 ECs3842 Escherichia coli O157:H7 str. Sakai transporter NP_311869.1 3851147 D 386585 CDS NP_311870.1 15833097 916338 3852233..3853498 1 NC_002695.1 similar to integrases e.g. [prophage P4] gi|6179516|emb|CAB59974.1; integrase 3853498 916338 ECs3843 Escherichia coli O157:H7 str. Sakai integrase NP_311870.1 3852233 D 386585 CDS NP_311873.1 15833100 916331 3854489..3855163 1 NC_002695.1 similar to hypothetical proteins e.g. ORF29 [Escherichia coli plasmid pB171] gi|6009405|dbj|BAA84864.1; hypothetical protein 3855163 916331 ECs3846 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311873.1 3854489 D 386585 CDS NP_311874.1 15833101 916332 3855160..3855507 1 NC_002695.1 similar to hypothetical proteins e.g. ORF30 [Escherichia coli plasmid pB171] gi|6009406|dbj|BAA84865.1; hypothetical protein 3855507 916332 ECs3847 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311874.1 3855160 D 386585 CDS NP_311875.1 15833102 916330 3855527..3856975 1 NC_002695.1 similar to hypothetical proteins e.g. ORF31 [Escherichia coli plasmid pB171] gi|6009427|dbj|BAA84886.1; hypothetical protein 3856975 916330 ECs3848 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311875.1 3855527 D 386585 CDS NP_311876.1 15833103 916329 complement(3856776..3857720) 1 NC_002695.1 similar to hypothetical protein [Salmonella choleraesuis] gi|7467227|pir||T28668; hypothetical protein 3857720 916329 ECs3849 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311876.1 3856776 R 386585 CDS NP_311877.1 15833104 916326 complement(3857829..3858377) 1 NC_002695.1 similar to virulence-related membrane proteins e.g. pagC [Salmonella typhimurium] gi|129558|sp|P23988|PAGC_SALTY; virulence-related membrane protein 3858377 916326 ECs3850 Escherichia coli O157:H7 str. Sakai virulence-related membrane protein NP_311877.1 3857829 R 386585 CDS NP_311879.1 15833106 916324 complement(3858950..3859150) 1 NC_002695.1 similar to hypothetical proteins e.g. FhaB [Neisseria meningitidis] gi|6900333|emb|CAB71945.1|; hypothetical protein 3859150 916324 ECs3852 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311879.1 3858950 R 386585 CDS NP_311881.1 15833108 916321 3860922..3861149 1 NC_002695.1 similar to KfaE [Escherichia coli] gi|628752|pir||S45104; hypothetical protein 3861149 916321 ECs3854 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311881.1 3860922 D 386585 CDS NP_944561.1 38704134 2693747 complement(3861082..3861276) 1 NC_002695.1 hypothetical protein 3861276 2693747 ECs5518 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944561.1 3861082 R 386585 CDS NP_311882.1 15833109 916322 3861357..3863006 1 NC_002695.1 similar to ShET2 enterotoxin [Shigella flexneri] gi|1109754|emb|CAA90938.1|, hypothetical proteins e.g. ankyrilike regulatory protein [Escherichia coli] gi|418526|sp|P2; enterotoxin 3863006 916322 ECs3855 Escherichia coli O157:H7 str. Sakai enterotoxin NP_311882.1 3861357 D 386585 CDS NP_311884.1 15833111 916317 3863614..3864603 1 NC_002695.1 similar to hypothetical protein [Salmonella typhimurium] gi|6960367|gb|AAF33527.1; hypothetical protein 3864603 916317 ECs3857 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311884.1 3863614 D 386585 CDS NP_311885.1 15833112 916318 3864652..3865326 1 NC_002695.1 hypothetical protein 3865326 916318 ECs3858 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311885.1 3864652 D 386585 CDS NP_311886.1 15833113 916319 3865761..3866549 1 NC_002695.1 similar to hypothetical proteins in insertion elements e.g. [IS630] gi|140943|sp|P16943|YIS5_SHISO; hypothetical protein 3866549 916319 ECs3859 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311886.1 3865761 D 386585 CDS NP_311889.1 15833116 916313 complement(3869375..3870265) 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to transposase [Escherichia coli plasmid pO157 IS629] gi|7443862|pir||T00240; transposase 3870265 916313 ECs3862 Escherichia coli O157:H7 str. Sakai transposase NP_311889.1 3869375 R 386585 CDS NP_311890.1 15833117 916312 complement(3870262..3870588) 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein [Escherichia coli plasmid pO157 IS629] gi|7444868|pir||T00241, hypothetical proteins in insertion sequences e.g. [Shigella flexneri] gi|5532454|gb|AAD44738.1|AF141323_9; transposase 3870588 916312 ECs3863 Escherichia coli O157:H7 str. Sakai transposase NP_311890.1 3870262 R 386585 CDS NP_311891.1 15833118 916311 complement(3870594..3870710) 1 NC_002695.1 hypothetical protein 3870710 916311 ECs3864 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311891.1 3870594 R 386585 CDS NP_311892.1 15833119 916309 3870779..3871126 1 NC_002695.1 similar to hypothetical proteins e.g. L0014 [Escherichia coli O157:H7 strain EDL933] gi|3414882|gb|AAC31493.1|; hypothetical protein 3871126 916309 ECs3865 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311892.1 3870779 D 386585 CDS NP_311893.1 15833120 916310 3871323..3872714 1 NC_002695.1 similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 3872714 916310 ECs3866 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311893.1 3871323 D 386585 CDS NP_311895.1 15833122 916306 3872937..3873287 1 NC_002695.1 similar to hypothetical proteins e.g. ORF50 [Escherichia coli plasmid pB171] gi|6009426|dbj|BAA84885.1|; hypothetical protein 3873287 916306 ECs3868 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311895.1 3872937 D 386585 CDS NP_311896.1 15833123 916299 3873500..3874903 1 NC_002695.1 similar to hypothetical proteins e.g. L0015 [Escherichia coli O157:H7 strain EDL933] gi|3414883|gb|AAC31494.1|; hypothetical protein 3874903 916299 ECs3869 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311896.1 3873500 D 386585 CDS NP_311898.1 15833125 916297 3875222..3875566 1 NC_002695.1 similar to hypothetical proteins e.g. L0004 [Escherichia coli O157:H7 strain EDL933] gi|3414872|gb|AAC31483.1|, transposase [Vibrio cholerae] gi|7960026|gb|AAF71186.1|AF179596_6; hypothetical protein 3875566 916297 ECs3871 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311898.1 3875222 D 386585 CDS NP_311899.1 15833126 916303 complement(3875409..3876725) 1 NC_002695.1 similar to PITB_ECOLI gi|1789360; low-affinity phosphate transport protein 3876725 916303 ECs3872 Escherichia coli O157:H7 str. Sakai low-affinity phosphate transport protein NP_311899.1 3875409 R 386585 CDS NP_311900.1 15833127 916304 complement(3877017..3878876) 1 NC_002695.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3878876 916304 ECs3873 Escherichia coli O157:H7 str. Sakai bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase NP_311900.1 3877017 R 386585 CDS NP_311901.2 38704135 916302 3879081..3879947 1 NC_002695.1 YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase 3879947 916302 ECs3874 Escherichia coli O157:H7 str. Sakai glutathione S-transferase NP_311901.2 3879081 D 386585 CDS NP_311902.1 15833129 916301 complement(3880070..3880318) 1 NC_002695.1 similar to HYBG_ECOLI gi|1789364 (conserved in Escherichia coli K-12); hydrogenase 2 accessory protein HypG 3880318 916301 ECs3875 Escherichia coli O157:H7 str. Sakai hydrogenase 2 accessory protein HypG NP_311902.1 3880070 R 386585 CDS NP_311903.1 15833130 916300 complement(3880331..3880672) 1 NC_002695.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3880672 hypA 916300 hypA Escherichia coli O157:H7 str. Sakai hydrogenase nickel incorporation protein HybF NP_311903.1 3880331 R 386585 CDS NP_311904.1 15833131 916298 complement(3880665..3881153) 1 NC_002695.1 similar to HYBE_ECOLI gi|1789366 (conserved in Escherichia coli K-12); hydrogenase 2-specific chaperone 3881153 916298 ECs3877 Escherichia coli O157:H7 str. Sakai hydrogenase 2-specific chaperone NP_311904.1 3880665 R 386585 CDS NP_311905.1 15833132 916296 complement(3881146..3881640) 1 NC_002695.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3881640 hybD 916296 hybD Escherichia coli O157:H7 str. Sakai hydrogenase 2 maturation endopeptidase NP_311905.1 3881146 R 386585 CDS NP_311906.1 15833133 916295 complement(3881640..3883343) 1 NC_002695.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3883343 916295 ECs3879 Escherichia coli O157:H7 str. Sakai hydrogenase 2 large subunit NP_311906.1 3881640 R 386585 CDS NP_311907.1 15833134 916282 complement(3883340..3884518) 1 NC_002695.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3884518 916282 ECs3880 Escherichia coli O157:H7 str. Sakai hydrogenase 2 b cytochrome subunit NP_311907.1 3883340 R 386585 CDS NP_311908.1 15833135 916288 complement(3884508..3885494) 1 NC_002695.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3885494 916288 ECs3881 Escherichia coli O157:H7 str. Sakai hydrogenase 2 protein HybA NP_311908.1 3884508 R 386585 CDS NP_311909.1 15833136 916289 complement(3885497..3886615) 1 NC_002695.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3886615 916289 ECs3882 Escherichia coli O157:H7 str. Sakai hydrogenase 2 small subunit NP_311909.1 3885497 R 386585 CDS NP_311910.1 15833137 916292 complement(3886804..3887091) 1 NC_002695.1 similar to B2998_ECOLI gi|1789372 (conserved in Escherichia coli K-12); hypothetical protein 3887091 916292 ECs3883 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311910.1 3886804 R 386585 CDS NP_311911.1 15833138 916294 complement(3887210..3888097) 1 NC_002695.1 similar to B3000_ECOLI gi|1789374, B2999_ECOLI gi|1789373; hypothetical protein 3888097 916294 ECs3884 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311911.1 3887210 R 386585 CDS NP_311912.1 15833139 916499 3888254..3889294 1 NC_002695.1 similar to B3001_ECOLI gi|1789375 (conserved in Escherichia coli K-12); aldo/keto reductase 3889294 916499 ECs3885 Escherichia coli O157:H7 str. Sakai aldo/keto reductase NP_311912.1 3888254 D 386585 CDS NP_311913.1 15833140 916291 complement(3889334..3889828) 1 NC_002695.1 similar to YQHA_ECOLI gi|1789376 (conserved in Escherichia coli K-12); hypothetical protein 3889828 916291 ECs3886 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311913.1 3889334 R 386585 CDS NP_311914.1 15833141 916290 3890019..3890903 1 NC_002695.1 similar to YGHA_ECOLI gi|1789378 (conserved in Escherichia coli K-12); oxidoreductase 3890903 916290 ECs3887 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311914.1 3890019 D 386585 CDS NP_311915.1 15833142 916286 3891079..3891324 1 NC_002695.1 similar to B3004_ECOLI gi|1789379 (conserved in Escherichia coli K-12); hypothetical protein 3891324 916286 ECs3888 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311915.1 3891079 D 386585 CDS NP_311916.1 15833143 916285 complement(3891175..3891600) 1 NC_002695.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3891600 916285 ECs3889 Escherichia coli O157:H7 str. Sakai biopolymer transport protein ExbD NP_311916.1 3891175 R 386585 CDS NP_311917.1 15833144 916284 complement(3891607..3892341) 1 NC_002695.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3892341 916284 ECs3890 Escherichia coli O157:H7 str. Sakai biopolymer transport protein ExbB NP_311917.1 3891607 R 386585 CDS NP_311918.1 15833145 916283 complement(3892334..3892489) 1 NC_002695.1 similar to B3007_ECOLI gi|1789382 (conserved in Escherichia coli K-12); hypothetical protein 3892489 916283 ECs3891 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311918.1 3892334 R 386585 CDS NP_311919.1 15833146 916277 3892593..3893780 1 NC_002695.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3893780 916277 ECs3892 Escherichia coli O157:H7 str. Sakai cystathionine beta-lyase NP_311919.1 3892593 D 386585 CDS NP_311920.1 15833147 916278 3893920..3894579 1 NC_002695.1 similar to YGHB_ECOLI gi|1789384 (conserved in Escherichia coli K-12); hypothetical protein 3894579 916278 ECs3893 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311920.1 3893920 D 386585 CDS NP_311921.2 38704136 916280 complement(3894619..3895575) 1 NC_002695.1 similar to YQHC_ECOLI gi|1789385 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 3895575 916280 ECs3895 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_311921.2 3894619 R 386585 CDS NP_311922.1 15833149 916281 3895712..3896875 1 NC_002695.1 similar to YQHD_ECOLI gi|1789386 (conserved in Escherichia coli K-12); oxidoreductase 3896875 916281 ECs3894 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311922.1 3895712 D 386585 CDS NP_311923.2 38704137 916279 3896980..3897807 1 NC_002695.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3897807 dkgA 916279 dkgA Escherichia coli O157:H7 str. Sakai 2,5-diketo-D-gluconate reductase A NP_311923.2 3896980 D 386585 CDS NP_311924.1 15833151 916488 3898007..3898282 1 NC_002695.1 similar to N-terminal part of YQHG_ECOLI gi|2367185; hypothetical protein 3898282 916488 ECs3897 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311924.1 3898007 D 386585 CDS NP_311925.1 15833152 916492 3898276..3898929 1 NC_002695.1 similar to C-terminal part of YQHG_ECOLI gi|2367185; hypothetical protein 3898929 916492 ECs3898 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311925.1 3898276 D 386585 CDS NP_311926.1 15833153 916271 3898978..3899235 1 NC_002695.1 similar to YQHH_ECOLI gi|1789390 (conserved in Escherichia coli K-12); outer membrane lipoprotein 3899235 916271 ECs3899 Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein NP_311926.1 3898978 D 386585 CDS NP_311927.1 15833154 916273 complement(3899278..3901497) 1 NC_002695.1 similar to YGIR_ECOLI similar to gi|1789392, B3015_ECOLI gi|1789391; hypothetical protein 3901497 916273 ECs3900 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311927.1 3899278 R 386585 CDS NP_311928.1 15833155 916275 complement(3901608..3903020) 1 NC_002695.1 similar to SUFI_ECOLI gi|1789394 (conserved in Escherichia coli K-12); repressor protein for FtsI 3903020 916275 ECs3901 Escherichia coli O157:H7 str. Sakai repressor protein for FtsI NP_311928.1 3901608 R 386585 CDS NP_311929.1 15833156 916276 complement(3903095..3903832) 1 NC_002695.1 similar to PLSC_ECOLI gi|1789395 (conserved in Escherichia coli K-12); 1-acyl-sn-glycerol-3-phosphate acyltransferase 3903832 916276 ECs3902 Escherichia coli O157:H7 str. Sakai 1-acyl-sn-glycerol-3-phosphate acyltransferase NP_311929.1 3903095 R 386585 CDS NP_311930.1 15833157 916274 complement(3904066..3906324) 1 NC_002695.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3906324 916274 ECs3903 Escherichia coli O157:H7 str. Sakai DNA topoisomerase IV subunit A NP_311930.1 3904066 R 386585 CDS NP_311931.1 15833158 916272 complement(3906462..3908069) 1 NC_002695.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; hypothetical protein 3908069 916272 ECs3904 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311931.1 3906462 R 386585 CDS NP_311932.1 15833159 916269 complement(3908178..3908660) 1 NC_002695.1 similar to B3023_ECOLI gi|1789400 (conserved in Escherichia coli K-12); hypothetical protein 3908660 916269 ECs3905 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311932.1 3908178 R 386585 CDS NP_311933.1 15833160 916268 complement(3908713..3909105) 1 NC_002695.1 similar to YGIW_ECOLI gi|1789401 (conserved in Escherichia coli K-12); hypothetical protein 3909105 916268 ECs3906 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311933.1 3908713 R 386585 CDS NP_311934.1 15833161 916262 3909257..3909916 1 NC_002695.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3909916 916262 ECs3907 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator QseB NP_311934.1 3909257 D 386585 CDS NP_311937.1 15833164 916264 3911371..3911952 1 NC_002695.1 similar to MDAB_ECOLI gi|1789406 (conserved in Escherichia coli K-12); modulator of drug activity B 3911952 916264 ECs3910 Escherichia coli O157:H7 str. Sakai modulator of drug activity B NP_311937.1 3911371 D 386585 CDS NP_311938.1 15833165 916263 3911983..3912297 1 NC_002695.1 similar to YGIN_ECOLI gi|1789407 (conserved in Escherichia coli K-12); hypothetical protein 3912297 916263 ECs3911 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311938.1 3911983 D 386585 CDS NP_311939.1 15833166 916261 complement(3912342..3913229) 1 NC_002695.1 similar to regulators (RpiR family) e.g. [Bacillus subtilis] gi|8248807|emb|CAB93068.1; transcriptional regulator 3913229 916261 ECs3912 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_311939.1 3912342 R 386585 CDS NP_311940.1 15833167 916259 complement(3913226..3914173) 1 NC_002695.1 similar to ferrichrome-binding proteins e.g. [Bacillus subtilis] gi|585132|sp|P37580|FHUD_BACSU; ferrichrome-binding protein 3914173 916259 ECs3913 Escherichia coli O157:H7 str. Sakai ferrichrome-binding protein NP_311940.1 3913226 R 386585 CDS NP_311941.1 15833168 916258 complement(3914184..3915233) 1 NC_002695.1 similar to ferrichrome ABC transporter (permease) e.g. [Bacillus subtilis] gi|1706797|sp|P49937|FHUG_BACSU; permease of ferrichrome ABC transporter 3915233 916258 ECs3914 Escherichia coli O157:H7 str. Sakai permease of ferrichrome ABC transporter NP_311941.1 3914184 R 386585 CDS NP_311942.1 15833169 916257 complement(3915230..3916213) 1 NC_002695.1 similar to ferrichrome ABC transporters (permease) e.g. [Synechocystis sp.] gi|7442493|pir||S74438, [Bacillus subtilis] gi|1706795|sp|P49936|FHUB_BACSU; permease of ferrichrome ABC transporter 3916213 916257 ECs3915 Escherichia coli O157:H7 str. Sakai permease of ferrichrome ABC transporter NP_311942.1 3915230 R 386585 CDS NP_311943.1 15833170 916256 complement(3916210..3917019) 1 NC_002695.1 similar to ABC-type iron-siderophore transport system ATP-binding proteins e.g. [Synechocystis sp.] gi|7442509|pir||S74440; iron-siderophore iron ABC transporter ATP-binding protein 3917019 916256 ECs3916 Escherichia coli O157:H7 str. Sakai iron-siderophore iron ABC transporter ATP-binding protein NP_311943.1 3916210 R 386585 CDS NP_311944.1 15833171 916251 3917393..3919534 1 NC_002695.1 similar to ferrichrome-iron receptor precursors e.g. gi|7448497|pir||S74457; ferrichrome iron receptor 3919534 916251 ECs3917 Escherichia coli O157:H7 str. Sakai ferrichrome iron receptor NP_311944.1 3917393 D 386585 CDS NP_311945.1 15833172 916252 complement(3919598..3921490) 1 NC_002695.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3921490 916252 ECs3918 Escherichia coli O157:H7 str. Sakai DNA topoisomerase IV subunit B NP_311945.1 3919598 R 386585 CDS NP_311946.1 15833173 916254 complement(3921519..3922100) 1 NC_002695.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3922100 916254 ECs3919 Escherichia coli O157:H7 str. Sakai esterase NP_311946.1 3921519 R 386585 CDS NP_311947.1 15833174 916255 complement(3922100..3922927) 1 NC_002695.1 similar to ICC_ECOLI gi|1789410 (conserved in Escherichia coli K-12); cyclic 3',5'-adenosine monophosphate phosphodiesterase 3922927 916255 ECs3920 Escherichia coli O157:H7 str. Sakai cyclic 3',5'-adenosine monophosphate phosphodiesterase NP_311947.1 3922100 R 386585 CDS NP_311948.1 15833175 916253 complement(3922952..3923374) 1 NC_002695.1 similar to YQIB_ECOLI gi|1789411 (conserved in Escherichia coli K-12); hypothetical protein 3923374 916253 ECs3921 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311948.1 3922952 R 386585 CDS NP_311949.1 15833176 916244 complement(3923375..3924004) 1 NC_002695.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 3924004 nudF 916244 nudF Escherichia coli O157:H7 str. Sakai ADP-ribose pyrophosphatase NP_311949.1 3923375 R 386585 CDS NP_311950.2 162139759 916248 3924209..3925690 1 NC_002695.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3925690 tolC 916248 tolC Escherichia coli O157:H7 str. Sakai outer membrane channel protein NP_311950.2 3924209 D 386585 CDS NP_311951.1 15833178 916249 3925690..3925950 1 NC_002695.1 similar to YGIA_ECOLI gi|1789414 (conserved in Escherichia coli K-12); hypothetical protein 3925950 916249 ECs3924 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311951.1 3925690 D 386585 CDS NP_311952.2 162139758 916246 3925838..3926509 1 NC_002695.1 similar to YGIB_ECOLI gi|1789415 (conserved in Escherichia coli K-12); hypothetical protein 3926509 916246 ECs3925 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311952.2 3925838 D 386585 CDS NP_311953.1 15833180 916245 3926515..3927675 1 NC_002695.1 similar to YGIC_ECOLI gi|1789416 (conserved in Escherichia coli K-12); synthetase/amidase 3927675 916245 ECs3926 Escherichia coli O157:H7 str. Sakai synthetase/amidase NP_311953.1 3926515 D 386585 CDS NP_311954.1 15833181 916243 complement(3927713..3928528) 1 NC_002695.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3928528 916243 ECs3927 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311954.1 3927713 R 386585 CDS NP_311955.1 15833182 916247 3928644..3929417 1 NC_002695.1 similar to YGIE_ECOLI gi|1789419 (conserved in Escherichia coli K-12); zinc transporter ZupT 3929417 916247 ECs3928 Escherichia coli O157:H7 str. Sakai zinc transporter ZupT NP_311955.1 3928644 D 386585 CDS NP_311956.1 15833183 916228 complement(3929907..3930560) 1 NC_002695.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3930560 ribB 916228 ribB Escherichia coli O157:H7 str. Sakai 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_311956.1 3929907 R 386585 CDS NP_311957.2 38704138 916227 3930898..3931233 1 NC_002695.1 similar to B3042_ECOLI gi|1789421 (conserved in Escherichia coli K-12); hypothetical protein 3931233 916227 ECs3930 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311957.2 3930898 D 386585 CDS NP_311958.1 15833185 916232 complement(3931268..3931468) 1 NC_002695.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3931468 916232 ECs3931 Escherichia coli O157:H7 str. Sakai glycogen synthesis protein GlgS NP_311958.1 3931268 R 386585 CDS NP_311959.1 15833186 916237 3931737..3932351 1 NC_002695.1 similar to B3050_ECOLI gi|1789429 (conserved in Escherichia coli K-12); oxidoreductase 3932351 916237 ECs3932 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311959.1 3931737 D 386585 CDS NP_311960.1 15833187 916242 3932393..3934054 1 NC_002695.1 similar to B3051_ECOLI gi|1789430 (conserved in Escherichia coli K-12); hypothetical protein 3934054 916242 ECs3933 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311960.1 3932393 D 386585 CDS NP_311961.1 15833188 916241 3934389..3934781 1 NC_002695.1 hypothetical protein 3934781 916241 ECs3934 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311961.1 3934389 D 386585 CDS NP_311962.1 15833189 916240 complement(3934848..3936281) 1 NC_002695.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3936281 916240 ECs3935 Escherichia coli O157:H7 str. Sakai bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase NP_311962.1 3934848 R 386585 CDS NP_311963.1 15833190 916239 complement(3936329..3939169) 1 NC_002695.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3939169 916239 ECs3936 Escherichia coli O157:H7 str. Sakai bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_311963.1 3936329 R 386585 CDS NP_311964.1 15833191 916238 complement(3939192..3940493) 1 NC_002695.1 similar to YGIF_ECOLI gi|1789434 (conserved in Escherichia coli K-12); hypothetical protein 3940493 916238 ECs3937 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311964.1 3939192 R 386585 CDS NP_311965.1 15833192 916236 3940735..3941355 1 NC_002695.1 similar to YGIM_ECOLI gi|1789435 (conserved in Escherichia coli K-12); signal transduction protein 3941355 916236 ECs3938 Escherichia coli O157:H7 str. Sakai signal transduction protein NP_311965.1 3940735 D 386585 CDS NP_311966.1 15833193 916235 3941419..3942657 1 NC_002695.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3942657 cca 916235 cca Escherichia coli O157:H7 str. Sakai multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase NP_311966.1 3941419 D 386585 CDS NP_311967.1 15833194 916234 complement(3942838..3943659) 1 NC_002695.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 3943659 uppP 916234 uppP Escherichia coli O157:H7 str. Sakai UDP pyrophosphate phosphatase NP_311967.1 3942838 R 386585 CDS NP_311968.1 15833195 916233 complement(3943750..3944121) 1 NC_002695.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3944121 folB 916233 folB Escherichia coli O157:H7 str. Sakai bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase NP_311968.1 3943750 R 386585 CDS NP_311969.1 15833196 916130 3944224..3944841 1 NC_002695.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3944841 916130 ECs3942 Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate acyltransferase PlsY NP_311969.1 3944224 D 386585 CDS NP_311970.1 15833197 916169 complement(3944854..3945786) 1 NC_002695.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3945786 916169 ECs3943 Escherichia coli O157:H7 str. Sakai transcriptional activator TtdR NP_311970.1 3944854 R 386585 CDS NP_311971.1 15833198 916192 3945993..3946904 1 NC_002695.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3946904 916192 ECs3944 Escherichia coli O157:H7 str. Sakai tartrate dehydratase subunit alpha NP_311971.1 3945993 D 386585 CDS NP_311972.1 15833199 916229 3946901..3947506 1 NC_002695.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3947506 916229 ECs3945 Escherichia coli O157:H7 str. Sakai L(+)-tartrate dehydratase subunit beta NP_311972.1 3946901 D 386585 CDS NP_311973.1 15833200 916226 3947555..3949018 1 NC_002695.1 similar to YGJE_ECOLI gi|1789444 (conserved in Escherichia coli K-12); hypothetical protein 3949018 916226 ECs3946 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311973.1 3947555 D 386585 CDS NP_311974.1 15833201 916225 complement(3949061..3950074) 1 NC_002695.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3950074 916225 ECs3947 Escherichia coli O157:H7 str. Sakai DNA-binding/iron metalloprotein/AP endonuclease NP_311974.1 3949061 R 386585 CDS NP_311975.1 15833202 916223 3950312..3950527 1 NC_002695.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3950527 rpsU 916223 rpsU Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S21 NP_311975.1 3950312 D 386585 CDS NP_311976.1 15833203 916216 3950638..3952383 1 NC_002695.1 synthesizes RNA primers at the replication forks; DNA primase 3952383 dnaG 916216 dnaG Escherichia coli O157:H7 str. Sakai DNA primase NP_311976.1 3950638 D 386585 CDS NP_311977.1 15833204 916217 3952578..3954419 1 NC_002695.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3954419 916217 ECs3950 Escherichia coli O157:H7 str. Sakai RNA polymerase sigma factor RpoD NP_311977.1 3952578 D 386585 CDS NP_311978.1 15833205 916221 complement(3954498..3955004) 1 NC_002695.1 similar to YGJF_ECOLI gi|1789449 (conserved in Escherichia coli K-12); G/U mismatch-specific DNA glycosylase 3955004 916221 ECs3951 Escherichia coli O157:H7 str. Sakai G/U mismatch-specific DNA glycosylase NP_311978.1 3954498 R 386585 CDS NP_311979.1 15833206 916220 complement(3955258..3956022) 1 NC_002695.1 similar to YQJH_ECOLI gi|1789450 (conserved in Escherichia coli K-12); hypothetical protein 3956022 916220 ECs3952 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311979.1 3955258 R 386585 CDS NP_311980.1 15833207 916218 3956310..3956933 1 NC_002695.1 similar to YQJI_ECOLI gi|1789452 (conserved in Escherichia coli K-12); hypothetical protein 3956933 916218 ECs3953 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311980.1 3956310 D 386585 CDS NP_311981.1 15833208 916215 complement(3957087..3958607) 1 NC_002695.1 similar to AER_ECOLI gi|1789453 (conserved in Escherichia coli K-12); aerotaxis sensor receptor 3958607 916215 ECs3954 Escherichia coli O157:H7 str. Sakai aerotaxis sensor receptor NP_311981.1 3957087 R 386585 CDS NP_311982.2 162139757 916214 3958998..3960404 1 NC_002695.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3960404 916214 ECs3955 Escherichia coli O157:H7 str. Sakai putrescine--2-oxoglutarate aminotransferase NP_311982.2 3958998 D 386585 CDS NP_311983.1 15833210 916206 complement(3960446..3960778) 1 NC_002695.1 similar to YGJH_ECOLI gi|1789455 (conserved in Escherichia coli K-12); hypothetical protein 3960778 916206 ECs3956 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311983.1 3960446 R 386585 CDS NP_311984.1 15833211 916208 3960997..3961980 1 NC_002695.1 similar to EBGR_ECOLI gi|1789456 (conserved in Escherichia coli K-12); DNA-binding transcriptional repressor EbgR 3961980 916208 ECs3957 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor EbgR NP_311984.1 3960997 D 386585 CDS NP_311985.2 38704139 916211 3962164..3965256 1 NC_002695.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3965256 ebgA 916211 ebgA Escherichia coli O157:H7 str. Sakai cryptic beta-D-galactosidase subunit alpha NP_311985.2 3962164 D 386585 CDS NP_311986.1 15833213 916212 3965253..3965702 1 NC_002695.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3965702 ebgC 916212 ebgC Escherichia coli O157:H7 str. Sakai cryptic beta-D-galactosidase subunit beta NP_311986.1 3965253 D 386585 CDS NP_311987.1 15833214 916209 3965765..3967198 1 NC_002695.1 similar to YGJI_ECOLI gi|1789459 (conserved in Escherichia coli K-12); oxidoreductase 3967198 916209 ECs3960 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_311987.1 3965765 D 386585 CDS NP_311988.1 15833215 916207 3967332..3968402 1 NC_002695.1 similar to YGJJ_ECOLI gi|1789461 (conserved in Escherichia coli K-12); hypothetical protein 3968402 916207 ECs3961 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311988.1 3967332 D 386585 CDS NP_311989.1 15833216 916204 3968419..3970770 1 NC_002695.1 similar to YGJK_ECOLI gi|1789462 (conserved in Escherichia coli K-12); glycosyl hydrolase 3970770 916204 ECs3962 Escherichia coli O157:H7 str. Sakai glycosyl hydrolase NP_311989.1 3968419 D 386585 CDS NP_311990.1 15833217 916198 3971296..3973314 1 NC_002695.1 similar to YGJL_ECOLI gi|1789463 (conserved in Escherichia coli K-12); NADPH dehydrogenase 3973314 916198 ECs3963 Escherichia coli O157:H7 str. Sakai NADPH dehydrogenase NP_311990.1 3971296 D 386585 CDS NP_311991.1 15833218 916199 complement(3973359..3973775) 1 NC_002695.1 similar to YGJM_ECOLI gi|1789464 (conserved in Escherichia coli K-12); hypothetical protein 3973775 916199 ECs3964 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311991.1 3973359 R 386585 CDS NP_311992.1 15833219 916202 complement(3973772..3974086) 1 NC_002695.1 similar to YGJN_ECOLI gi|1789465 (conserved in Escherichia coli K-12); hypothetical protein 3974086 916202 ECs3965 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311992.1 3973772 R 386585 CDS NP_311993.2 38704140 916203 complement(3974370..3975506) 1 NC_002695.1 similar to YGJO_ECOLI gi|1789466 (conserved in Escherichia coli K-12); hypothetical protein 3975506 916203 ECs3966 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311993.2 3974370 R 386585 CDS NP_311994.1 15833221 916201 3975555..3976094 1 NC_002695.1 similar to YGJP_ECOLI gi|1789467 (conserved in Escherichia coli K-12); hypothetical protein 3976094 916201 ECs3967 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311994.1 3975555 D 386585 CDS NP_311995.1 15833222 916200 3976171..3976863 1 NC_002695.1 similar to YGJQ_ECOLI gi|1789468 (conserved in Escherichia coli K-12); hypothetical protein 3976863 916200 ECs3968 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311995.1 3976171 D 386585 CDS NP_311996.1 15833223 916197 3976924..3977928 1 NC_002695.1 similar to YGJR_ECOLI gi|2367190 (conserved in Escherichia coli K-12); hypothetical protein 3977928 916197 ECs3969 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311996.1 3976924 D 386585 CDS NP_311997.1 15833224 916186 3978212..3979177 1 NC_002695.1 similar to YGJT_ECOLI gi|1789472 (conserved in Escherichia coli K-12); transporter 3979177 916186 ECs3970 Escherichia coli O157:H7 str. Sakai transporter NP_311997.1 3978212 D 386585 CDS NP_311998.1 15833225 916190 3979576..3980820 1 NC_002695.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3980820 916190 ECs3971 Escherichia coli O157:H7 str. Sakai serine/threonine transporter SstT NP_311998.1 3979576 D 386585 CDS NP_311999.1 15833226 916194 complement(3980825..3981376) 1 NC_002695.1 similar to YGJV_ECOLI gi|1789474 (conserved in Escherichia coli K-12); hypothetical protein 3981376 916194 ECs3972 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_311999.1 3980825 R 386585 CDS NP_312000.1 15833227 916195 complement(3981459..3982946) 1 NC_002695.1 similar to UXAA_ECOLI gi|1789475 (conserved in Escherichia coli K-12); altronate hydrolase 3982946 916195 ECs3973 Escherichia coli O157:H7 str. Sakai altronate hydrolase NP_312000.1 3981459 R 386585 CDS NP_312001.1 15833228 916193 complement(3982961..3984373) 1 NC_002695.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3984373 916193 ECs3974 Escherichia coli O157:H7 str. Sakai glucuronate isomerase NP_312001.1 3982961 R 386585 CDS NP_312002.1 15833229 916191 3984736..3986154 1 NC_002695.1 similar to EXUT_ECOLI gi|2367193 (conserved in Escherichia coli K-12); hexuronates transport protein 3986154 916191 ECs3975 Escherichia coli O157:H7 str. Sakai hexuronates transport protein NP_312002.1 3984736 D 386585 CDS NP_312003.2 162139756 916189 3986284..3987060 1 NC_002695.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3987060 916189 ECs3976 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor ExuR NP_312003.2 3986284 D 386585 CDS NP_312004.1 15833231 916188 3987405..3988067 1 NC_002695.1 similar to YQJA_ECOLI gi|1789481 (conserved in Escherichia coli K-12); hypothetical protein 3988067 916188 ECs3977 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312004.1 3987405 D 386585 CDS NP_312005.1 15833232 916184 3988071..3988454 1 NC_002695.1 similar to YQJB_ECOLI gi|1789482 (conserved in Escherichia coli K-12); hypothetical protein 3988454 916184 ECs3978 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312005.1 3988071 D 386585 CDS NP_312006.2 229544780 916185 3988601..3988969 1 NC_002695.1 similar to YQJC_ECOLI gi|2367195 (Conserved in E.coli K-q2); hypothetical protein 3988969 916185 ECs3979 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312006.2 3988601 D 386585 CDS NP_312007.1 15833234 916205 3989007..3989312 1 NC_002695.1 similar to YQJD_ECOLI gi|1789485 (conserved in Escherichia coli K-12); hypothetical protein 3989312 916205 ECs3980 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312007.1 3989007 D 386585 CDS NP_312008.1 15833235 916196 3989315..3989719 1 NC_002695.1 similar to YQJE_ECOLI gi|1789486 (conserved in Escherichia coli K-12); hypothetical protein 3989719 916196 ECs3981 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312008.1 3989315 D 386585 CDS NP_312009.1 15833236 916210 3989709..3990008 1 NC_002695.1 similar to B3100_ECOLI gi|1789487 (conserved in Escherichia coli K-12); hypothetical protein 3990008 916210 ECs3982 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312009.1 3989709 D 386585 CDS NP_312010.1 15833237 916177 3990104..3990586 1 NC_002695.1 similar to YQJF_ECOLI gi|1789488 (conserved in Escherichia coli K-12); hypothetical protein 3990586 916177 ECs3983 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312010.1 3990104 D 386585 CDS NP_312011.1 15833238 916178 3990656..3991642 1 NC_002695.1 similar to YQJG_ECOLI gi|1789489 (conserved in Escherichia coli K-12); transferase 3991642 916178 ECs3984 Escherichia coli O157:H7 str. Sakai transferase NP_312011.1 3990656 D 386585 CDS NP_312012.1 15833239 916181 3991934..3992299 1 NC_002695.1 similar to YHAH_ECOLI gi|2367196 (conserved in Escherichia coli K-12); cytochrome 3992299 916181 ECs3985 Escherichia coli O157:H7 str. Sakai cytochrome NP_312012.1 3991934 D 386585 CDS NP_312013.1 15833240 916183 3992540..3992896 1 NC_002695.1 similar to YHAI_ECOLI gi|1789491 (conserved in Escherichia coli K-12); cytochrome 3992896 916183 ECs3986 Escherichia coli O157:H7 str. Sakai cytochrome NP_312013.1 3992540 D 386585 CDS NP_312014.1 15833241 916179 complement(3992947..3993843) 1 NC_002695.1 similar to YHAJ_ECOLI gi|1789492 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 3993843 916179 ECs3987 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_312014.1 3992947 R 386585 CDS NP_312015.1 15833242 916176 3993948..3994649 1 NC_002695.1 similar to YHAK_ECOLI gi|1789493 (conserved in Escherichia coli K-12); hypothetical protein 3994649 916176 ECs3988 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312015.1 3993948 D 386585 CDS NP_312016.1 15833243 916174 3994666..3994836 1 NC_002695.1 similar to YHAL_ECOLI gi|1789494 (conserved in Escherichia coli K-12); hypothetical protein 3994836 916174 ECs3989 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312016.1 3994666 D 386585 CDS NP_312017.1 15833244 916164 complement(3994970..3996280) 1 NC_002695.1 similar to YHAN_ECOLI gi|1789496, YHAM_ECOLI gi|1789495; hypothetical protein 3996280 916164 ECs3990 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312017.1 3994970 R 386585 CDS NP_312018.1 15833245 916166 complement(3996308..3997639) 1 NC_002695.1 similar to YHAO_ECOLI gi|1789497 (conserved in Escherichia coli K-12); transport system permease 3997639 916166 ECs3991 Escherichia coli O157:H7 str. Sakai transport system permease NP_312018.1 3996308 R 386585 CDS NP_312019.1 15833246 916172 complement(3997914..3999278) 1 NC_002695.1 similar to YHAQ_ECOLI gi|1789500, YHAP_ECOLI gi|1789498, L-serine deaminase gi|1788116; L-serine deaminase 3999278 916172 ECs3992 Escherichia coli O157:H7 str. Sakai L-serine deaminase NP_312019.1 3997914 R 386585 CDS NP_312020.2 38704141 916173 complement(3999350..3999739) 1 NC_002695.1 similar to YHAR_ECOLI gi|1789501 (conserved in Escherichia coli K-12); hypothetical protein 3999739 916173 ECs3993 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312020.2 3999350 R 386585 CDS NP_312021.1 15833248 916171 complement(3999753..4002047) 1 NC_002695.1 similar to TDCE_ECOLI gi|1789502 (conserved in Escherichia coli K-12); formate acetyltransferase 3 4002047 916171 ECs3994 Escherichia coli O157:H7 str. Sakai formate acetyltransferase 3 NP_312021.1 3999753 R 386585 CDS NP_312022.1 15833249 916170 complement(4002081..4003301) 1 NC_002695.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 4003301 916170 ECs3995 Escherichia coli O157:H7 str. Sakai propionate/acetate kinase NP_312022.1 4002081 R 386585 CDS NP_312023.1 15833250 916533 complement(4003315..4004646) 1 NC_002695.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 4004646 916533 ECs3996 Escherichia coli O157:H7 str. Sakai threonine/serine transporter TdcC NP_312023.1 4003315 R 386585 CDS NP_312024.1 15833251 916167 complement(4004668..4005657) 1 NC_002695.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 4005657 916167 ECs3997 Escherichia coli O157:H7 str. Sakai threonine dehydratase NP_312024.1 4004668 R 386585 CDS NP_312025.1 15833252 916165 complement(4005756..4006694) 1 NC_002695.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; TdcA family transcriptional regulator 4006694 916165 ECs3998 Escherichia coli O157:H7 str. Sakai TdcA family transcriptional regulator NP_312025.1 4005756 R 386585 CDS NP_312026.1 15833253 916156 4006883..4007227 1 NC_002695.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; TdcR family transcriptional regulator 4007227 916156 ECs3999 Escherichia coli O157:H7 str. Sakai TdcR family transcriptional regulator NP_312026.1 4006883 D 386585 CDS NP_312027.1 15833254 916153 4007462..4008022 1 NC_002695.1 similar to YHAB_ECOLI gi|1789508 (conserved in Escherichia coli K-12); hypothetical protein 4008022 916153 ECs4000 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312027.1 4007462 D 386585 CDS NP_312028.1 15833255 916149 4008044..4009231 1 NC_002695.1 similar to YHAC_ECOLI gi|1789509 (conserved in Escherichia coli K-12); hypothetical protein 4009231 916149 ECs4001 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312028.1 4008044 D 386585 CDS NP_312029.2 38704142 916168 complement(4009860..4011005) 1 NC_002695.1 similar to YHAD_ECOLI gi|1789512 (conserved in Escherichia coli K-12); glycerate kinase 4011005 916168 ECs4002 Escherichia coli O157:H7 str. Sakai glycerate kinase NP_312029.2 4009860 R 386585 CDS NP_312030.2 162139755 916157 complement(4011102..4011992) 1 NC_002695.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 4011992 garR 916157 garR Escherichia coli O157:H7 str. Sakai tartronate semialdehyde reductase NP_312030.2 4011102 R 386585 CDS NP_312031.1 15833258 916159 complement(4012022..4012792) 1 NC_002695.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 4012792 916159 ECs4004 Escherichia coli O157:H7 str. Sakai alpha-dehydro-beta-deoxy-D-glucarate aldolase NP_312031.1 4012022 R 386585 CDS NP_312032.1 15833259 916162 complement(4012808..4014142) 1 NC_002695.1 similar to YHAU_ECOLI gi|1789515 (conserved in Escherichia coli K-12); transporter 4014142 916162 ECs4005 Escherichia coli O157:H7 str. Sakai transporter NP_312032.1 4012808 R 386585 CDS NP_312033.1 15833260 916161 4014517..4016088 1 NC_002695.1 similar to YHAG_ECOLI gi|1789516 (conserved in Escherichia coli K-12); hydrolase 4016088 916161 ECs4006 Escherichia coli O157:H7 str. Sakai hydrolase NP_312033.1 4014517 D 386585 CDS NP_312034.1 15833261 916160 4016237..4016572 1 NC_002695.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 4016572 916160 ECs4007 Escherichia coli O157:H7 str. Sakai regulator PrlF NP_312034.1 4016237 D 386585 CDS NP_312035.1 15833262 916158 4016572..4017036 1 NC_002695.1 similar to YHAV_ECOLI gi|1789518 (conserved in Escherichia coli K-12); hypothetical protein 4017036 916158 ECs4008 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312035.1 4016572 D 386585 CDS NP_312036.1 15833263 916155 complement(4017091..4017900) 1 NC_002695.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; AgaR family transcriptional regulator 4017900 916155 ECs4009 Escherichia coli O157:H7 str. Sakai AgaR family transcriptional regulator NP_312036.1 4017091 R 386585 CDS NP_312037.1 15833264 916154 4018149..4019429 1 NC_002695.1 similar to KBAZ_ECOLI (strain C) dad|AF228498-2|AAF81082.1 (conserved in Escherichia coli K-12); tagatose 6-phosphate kinase 2 4019429 916154 ECs4010 Escherichia coli O157:H7 str. Sakai tagatose 6-phosphate kinase 2 NP_312037.1 4018149 D 386585 CDS NP_312038.2 38704143 916508 4019452..4019925 1 NC_002695.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4019925 916508 ECs4011 Escherichia coli O157:H7 str. Sakai PTS system N-acetylgalactosamine-specific transporter subunit IIB NP_312038.2 4019452 D 386585 CDS NP_312039.1 15833266 916519 4019936..4020715 1 NC_002695.1 similar to AGAW_ECOLI (strain C) gi|8895748|gb|AAF81084.1|AF228498_4; N-acetylgalactosamine-specific PTS system enzyme IIC component 4020715 916519 ECs4012 Escherichia coli O157:H7 str. Sakai N-acetylgalactosamine-specific PTS system enzyme IIC component NP_312039.1 4019936 D 386585 CDS NP_312040.1 15833267 916505 4020705..4021583 1 NC_002695.1 AgaE; similar to PTS dependent N-acetyl-galactosamine-IID component, AgaE [Escherichia coli strain C] gi|8895749|gb|AAF81085.1|AF228498_5; N-acetylgalactosamine-specific PTS system enzyme IID component 4021583 916505 ECs4013 Escherichia coli O157:H7 str. Sakai N-acetylgalactosamine-specific PTS system enzyme IID component NP_312040.1 4020705 D 386585 CDS NP_312041.1 15833268 916152 4021601..4022035 1 NC_002695.1 AfaF; similar to ts dependent N-acetyl-galactosamine- and galactosamine IIA component, AgaF [Escherichia coli strain C] gi|8895750|gb|AAF81086.1|AF228498_6; N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component 4022035 916152 ECs4014 Escherichia coli O157:H7 str. Sakai N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component NP_312041.1 4021601 D 386585 CDS NP_312042.1 15833269 916151 4022011..4023165 1 NC_002695.1 similar to AGAA_ECOLI (strain C) gi|8895751|dad|AF228498-7|AAF81087.1; N-acetylgalactosamine-6-phosphate deacetylase 4023165 916151 ECs4015 Escherichia coli O157:H7 str. Sakai N-acetylgalactosamine-6-phosphate deacetylase NP_312042.1 4022011 D 386585 CDS NP_312043.1 15833270 916150 4023516..4024670 1 NC_002695.1 similar to AGAS_ECOLI (strain C) dad|AF228498-8|AAF81088.1 (conserved in Escherichia coli K-12); tagatose-6-phosphate aldose/ketose isomerase 4024670 916150 ECs4016 Escherichia coli O157:H7 str. Sakai tagatose-6-phosphate aldose/ketose isomerase NP_312043.1 4023516 D 386585 CDS NP_312044.1 15833271 916148 4024683..4025543 1 NC_002695.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 4025543 kbaY 916148 kbaY Escherichia coli O157:H7 str. Sakai tagatose-bisphosphate aldolase NP_312044.1 4024683 D 386585 CDS NP_312045.1 15833272 916140 4025710..4026186 1 NC_002695.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4026186 916140 ECs4018 Escherichia coli O157:H7 str. Sakai PTS system N-acetylgalactosamine-specific transporter subunit IIB NP_312045.1 4025710 D 386585 CDS NP_312046.1 15833273 916141 4027018..4027809 1 NC_002695.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 4027809 916141 ECs4019 Escherichia coli O157:H7 str. Sakai PTS system N-acetylgalactosamine-specific transporter subunit IID NP_312046.1 4027018 D 386585 CDS NP_312047.1 15833274 916146 4028966..4029550 1 NC_002695.1 similar to YRAH_ECOLI gi|1789531 (conserved in Escherichia coli K-12); fimbrial-like protein 4029550 916146 ECs4020 Escherichia coli O157:H7 str. Sakai fimbrial-like protein NP_312047.1 4028966 D 386585 CDS NP_312048.1 15833275 916145 4029630..4030325 1 NC_002695.1 similar to YRAI_ECOLI gi|1789532 (conserved in Escherichia coli K-12); chaperone 4030325 916145 ECs4021 Escherichia coli O157:H7 str. Sakai chaperone NP_312048.1 4029630 D 386585 CDS NP_312049.1 15833276 916144 4030354..4032870 1 NC_002695.1 similar to YRAJ_ECOLI gi|1789533 (conserved in Escherichia coli K-12); outer membrane protein 4032870 916144 ECs4022 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_312049.1 4030354 D 386585 CDS NP_312050.1 15833277 916142 4032881..4033234 1 NC_002695.1 similar to fimbrial protein YRAK_ECOLI gi|1789534; hypothetical protein 4033234 916142 ECs4023 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312050.1 4032881 D 386585 CDS NP_312051.1 15833278 916138 4033260..4033586 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to hypothetical protein gi|7444868|pir||T00241; transposase 4033586 916138 ECs4024 Escherichia coli O157:H7 str. Sakai transposase NP_312051.1 4033260 D 386585 CDS NP_312052.1 15833279 916137 4033583..4034473 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to gi|7443862|pir||T00240; transposase 4034473 916137 ECs4025 Escherichia coli O157:H7 str. Sakai transposase NP_312052.1 4033583 D 386585 CDS NP_312053.1 15833280 916136 4034457..4034930 1 NC_002695.1 similar to YRAK_ECOLI gi|1789534; fimbrial protein 4034930 916136 ECs4026 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_312053.1 4034457 D 386585 CDS NP_312054.1 15833281 916135 complement(4034973..4035833) 1 NC_002695.1 similar to YRAL_ECOLI gi|1789535 (conserved in Escherichia coli K-12); hypothetical protein 4035833 916135 ECs4027 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312054.1 4034973 R 386585 CDS NP_312055.1 15833282 916134 4035898..4037934 1 NC_002695.1 similar to YRAM_ECOLI gi|1789537 (conserved in Escherichia coli K-12); glycosylase 4037934 916134 ECs4028 Escherichia coli O157:H7 str. Sakai glycosylase NP_312055.1 4035898 D 386585 CDS NP_312056.1 15833283 916133 4037892..4038287 1 NC_002695.1 similar to YRAN_ECOLI gi|1789538 (conserved in Escherichia coli K-12); hypothetical protein 4038287 916133 ECs4029 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312056.1 4037892 D 386585 CDS NP_312057.1 15833284 916132 4038307..4038897 1 NC_002695.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 4038897 916132 ECs4030 Escherichia coli O157:H7 str. Sakai DnaA initiator-associating protein DiaA NP_312057.1 4038307 D 386585 CDS NP_312058.1 15833285 916131 4038907..4039482 1 NC_002695.1 similar to YRAP_ECOLI gi|1789540 (conserved in Escherichia coli K-12); hypothetical protein 4039482 916131 ECs4031 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312058.1 4038907 D 386585 CDS NP_312059.1 15833286 916129 complement(4039596..4040636) 1 NC_002695.1 similar to YRAQ_ECOLI gi|1789541 (conserved in Escherichia coli K-12); hypothetical protein 4040636 916129 ECs4032 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312059.1 4039596 R 386585 CDS NP_312060.1 15833287 916128 complement(4040709..4041389) 1 NC_002695.1 similar to YRAR_ECOLI gi|1789542 (conserved in Escherichia coli K-12); hypothetical protein 4041389 916128 ECs4033 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312060.1 4040709 R 386585 CDS NP_312061.1 15833288 916127 4041430..4041990 1 NC_002695.1 similar to YHBO_ECOLI gi|1789543 (conserved in Escherichia coli K-12); hypothetical protein 4041990 916127 ECs4034 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312061.1 4041430 D 386585 CDS NP_312062.1 15833289 916126 complement(4041970..4042413) 1 NC_002695.1 similar to YHBP_ECOLI gi|1789544 (conserved in Escherichia coli K-12); hypothetical protein 4042413 916126 ECs4035 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312062.1 4041970 R 386585 CDS NP_312063.1 15833290 916111 4042464..4042766 1 NC_002695.1 similar to YHBQ_ECOLI gi|1789545 (conserved in Escherichia coli K-12); GIY-YIG nuclease superfamily protein 4042766 916111 ECs4036 Escherichia coli O157:H7 str. Sakai GIY-YIG nuclease superfamily protein NP_312063.1 4042464 D 386585 CDS NP_312064.1 15833291 916114 complement(4042753..4043256) 1 NC_002695.1 similar to YHBS_ECOLI gi|1789546 (conserved in Escherichia coli K-12); hypothetical protein 4043256 916114 ECs4037 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312064.1 4042753 R 386585 CDS NP_312065.1 15833292 916123 complement(4043250..4043774) 1 NC_002695.1 similar to YHBT_ECOLI gi|1789547 (conserved in Escherichia coli K-12); hypothetical protein 4043774 916123 ECs4038 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312065.1 4043250 R 386585 CDS NP_312066.1 15833293 916124 4043983..4044978 1 NC_002695.1 similar to YHBU_ECOLI gi|1789548 (conserved in Escherichia coli K-12); collagenase 4044978 916124 ECs4039 Escherichia coli O157:H7 str. Sakai collagenase NP_312066.1 4043983 D 386585 CDS NP_312067.1 15833294 916122 4044969..4045865 1 NC_002695.1 similar to YHBV_ECOLI gi|1789549 (conserved in Escherichia coli K-12); hypothetical protein 4045865 916122 ECs4040 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312067.1 4044969 D 386585 CDS NP_312068.1 15833295 916121 4045946..4046953 1 NC_002695.1 similar to YHBW_ECOLI gi|1789551 (conserved in Escherichia coli K-12); hypothetical protein 4046953 916121 ECs4041 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312068.1 4045946 D 386585 CDS NP_312069.1 15833296 916120 complement(4047070..4048314) 1 NC_002695.1 tryptophan transporter of high affinity; tryptophan permease 4048314 916120 ECs4042 Escherichia coli O157:H7 str. Sakai tryptophan permease NP_312069.1 4047070 R 386585 CDS NP_312070.2 38704144 916119 complement(4048468..4050357) 1 NC_002695.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 4050357 916119 ECs4043 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase DeaD NP_312070.2 4048468 R 386585 CDS NP_312071.1 15833298 916118 complement(4050537..4051421) 1 NC_002695.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; Nlp family transcriptional regulator 4051421 916118 ECs4044 Escherichia coli O157:H7 str. Sakai Nlp family transcriptional regulator NP_312071.1 4050537 R 386585 CDS NP_312072.1 15833299 916115 complement(4051530..4053734) 1 NC_002695.1 similar to PNP_ECOLI gi|1789555 (conserved in Escherichia coli K-12); polynucleotide phosphorylase 4053734 916115 ECs4045 Escherichia coli O157:H7 str. Sakai polynucleotide phosphorylase NP_312072.1 4051530 R 386585 CDS NP_312073.1 15833300 916113 complement(4053912..4054181) 1 NC_002695.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 4054181 rpsO 916113 rpsO Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S15 NP_312073.1 4053912 R 386585 CDS NP_312074.1 15833301 916110 complement(4054330..4055274) 1 NC_002695.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 4055274 truB 916110 truB Escherichia coli O157:H7 str. Sakai tRNA pseudouridine synthase B NP_312074.1 4054330 R 386585 CDS NP_312075.1 15833302 916109 complement(4055274..4055675) 1 NC_002695.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 4055675 rbfA 916109 rbfA Escherichia coli O157:H7 str. Sakai ribosome-binding factor A NP_312075.1 4055274 R 386585 CDS NP_312076.1 15833303 916116 complement(4055840..4058512) 1 NC_002695.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 4058512 infB 916116 infB Escherichia coli O157:H7 str. Sakai translation initiation factor IF-2 NP_312076.1 4055840 R 386585 CDS NP_312077.1 15833304 916098 complement(4058537..4060024) 1 NC_002695.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 4060024 nusA 916098 nusA Escherichia coli O157:H7 str. Sakai transcription elongation factor NusA NP_312077.1 4058537 R 386585 CDS NP_312078.3 162139721 916100 complement(4060052..4060504) 1 NC_002695.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 4060504 916100 ECs4051 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312078.3 4060052 R 386585 CDS NP_312079.1 15833306 916108 4061135..4062478 1 NC_002695.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 4062478 916108 ECs4052 Escherichia coli O157:H7 str. Sakai argininosuccinate synthase NP_312079.1 4061135 D 386585 CDS NP_312080.1 15833307 916107 complement(4062486..4064129) 1 NC_002695.1 similar to YHBX_ECOLI gi|1789564 (conserved in Escherichia coli K-12); alkaline phosphatase 4064129 916107 ECs4053 Escherichia coli O157:H7 str. Sakai alkaline phosphatase NP_312080.1 4062486 R 386585 CDS NP_312081.1 15833308 916105 complement(4064671..4065003) 1 NC_002695.1 protein-export protein; similar to SECG_ECOLI gi|1789565 (conserved in Escherichia coli K-12); preprotein translocase subunit SecG 4065003 secG 916105 secG Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecG NP_312081.1 4064671 R 386585 CDS NP_312082.1 15833309 916104 complement(4065231..4066568) 1 NC_002695.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 4066568 glmM 916104 glmM Escherichia coli O157:H7 str. Sakai phosphoglucosamine mutase NP_312082.1 4065231 R 386585 CDS NP_312083.2 38704146 916103 complement(4066561..4067409) 1 NC_002695.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 4067409 folP 916103 folP Escherichia coli O157:H7 str. Sakai dihydropteroate synthase NP_312083.2 4066561 R 386585 CDS NP_312084.1 15833311 916102 complement(4067499..4069433) 1 NC_002695.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 4069433 hflB 916102 hflB Escherichia coli O157:H7 str. Sakai ATP-dependent metalloprotease NP_312084.1 4067499 R 386585 CDS NP_312085.1 15833312 916101 complement(4069533..4070162) 1 NC_002695.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 4070162 rrmJ 916101 rrmJ Escherichia coli O157:H7 str. Sakai 23S rRNA methyltransferase NP_312085.1 4069533 R 386585 CDS NP_312086.1 15833313 916097 4070288..4070581 1 NC_002695.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 4070581 916097 ECs4059 Escherichia coli O157:H7 str. Sakai RNA-binding protein YhbY NP_312086.1 4070288 D 386585 CDS NP_312087.2 38704147 916087 complement(4070737..4071213) 1 NC_002695.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 4071213 greA 916087 greA Escherichia coli O157:H7 str. Sakai transcription elongation factor GreA NP_312087.2 4070737 R 386585 CDS NP_312088.1 15833315 916092 4071461..4072894 1 NC_002695.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 4072894 916092 ECs4061 Escherichia coli O157:H7 str. Sakai D-alanyl-D-alanine carboxypeptidase NP_312088.1 4071461 D 386585 CDS NP_312089.1 15833316 916094 complement(4072934..4074106) 1 NC_002695.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 4074106 obgE 916094 obgE Escherichia coli O157:H7 str. Sakai GTPase ObgE NP_312089.1 4072934 R 386585 CDS NP_312090.1 15833317 916095 complement(4074122..4075087) 1 NC_002695.1 similar to YHBE_ECOLI gi|1789575 (conserved in Escherichia coli K-12); hypothetical protein 4075087 916095 ECs4063 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312090.1 4074122 R 386585 CDS NP_312091.1 15833318 916093 complement(4075214..4075471) 1 NC_002695.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 4075471 rpmA 916093 rpmA Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L27 NP_312091.1 4075214 R 386585 CDS NP_312092.1 15833319 916091 complement(4075492..4075803) 1 NC_002695.1 similar to RPLU_ECOLI gi|1789577 (conserved in Escherichia coli K-12); 50S ribosomal protein L21 4075803 rplU 916091 rplU Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L21 NP_312092.1 4075492 R 386585 CDS NP_312093.1 15833320 916090 4076062..4077033 1 NC_002695.1 similar to ISPB_ECOLI gi|1789578 (conserved in Escherichia coli K-12); octaprenyl diphosphate synthase 4077033 916090 ECs4066 Escherichia coli O157:H7 str. Sakai octaprenyl diphosphate synthase NP_312093.1 4076062 D 386585 CDS NP_312094.1 15833321 916088 4077262..4077540 1 NC_002695.1 activator of maltose metabolism genes; Nlp family transcriptional regulator 4077540 916088 ECs4067 Escherichia coli O157:H7 str. Sakai Nlp family transcriptional regulator NP_312094.1 4077262 D 386585 CDS NP_312095.1 15833322 916085 complement(4077588..4078847) 1 NC_002695.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 4078847 916085 ECs4068 Escherichia coli O157:H7 str. Sakai UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_312095.1 4077588 R 386585 CDS NP_312096.1 15833323 916072 complement(4078902..4079171) 1 NC_002695.1 similar to YRBA_ECOLI gi|1789581 (conserved in Escherichia coli K-12); hypothetical protein 4079171 916072 ECs4069 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312096.1 4078902 R 386585 CDS NP_312097.2 38704148 916078 complement(4079316..4079609) 1 NC_002695.1 similar to YRBB_ECOLI gi|1789582 (conserved in Escherichia coli K-12); hypothetical protein 4079609 916078 ECs4070 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312097.2 4079316 R 386585 CDS NP_312098.1 15833325 916079 complement(4079609..4080244) 1 NC_002695.1 similar to YRBC_ECOLI gi|1789583 (conserved in Escherichia coli K-12); hypothetical protein 4080244 916079 ECs4071 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312098.1 4079609 R 386585 CDS NP_312099.1 15833326 916081 complement(4080263..4080814) 1 NC_002695.1 similar to YRBD_ECOLI gi|1789584 (conserved in Escherichia coli K-12); hypothetical protein 4080814 916081 ECs4072 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312099.1 4080263 R 386585 CDS NP_312100.1 15833327 916084 complement(4080819..4081601) 1 NC_002695.1 similar to YRBE_ECOLI gi|1789585 (conserved in Escherichia coli K-12); hypothetical protein 4081601 916084 ECs4073 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312100.1 4080819 R 386585 CDS NP_312101.1 15833328 916083 complement(4081609..4082418) 1 NC_002695.1 ATP-binding protein of a ABC toluene efflux transporter; ABC transporter ATP-binding protein 4082418 916083 ECs4074 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_312101.1 4081609 R 386585 CDS NP_312102.1 15833329 916082 4082628..4083605 1 NC_002695.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 4083605 916082 ECs4075 Escherichia coli O157:H7 str. Sakai calcium/sodium:proton antiporter NP_312102.1 4082628 D 386585 CDS NP_312103.1 15833330 916080 4083619..4084605 1 NC_002695.1 similar to YRBH_ECOLI gi|1789588 (conserved in Escherichia coli K-12); D-arabinose 5-phosphate isomerase 4084605 916080 ECs4076 Escherichia coli O157:H7 str. Sakai D-arabinose 5-phosphate isomerase NP_312103.1 4083619 D 386585 CDS NP_312104.1 15833331 916077 4084626..4085192 1 NC_002695.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 4085192 916077 ECs4077 Escherichia coli O157:H7 str. Sakai 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase NP_312104.1 4084626 D 386585 CDS NP_312105.1 15833332 916076 4085189..4085764 1 NC_002695.1 similar to YRBK_ECOLI gi|1789591 (conserved in Escherichia coli K-12); hypothetical protein 4085764 916076 ECs4078 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312105.1 4085189 D 386585 CDS NP_312106.1 15833333 916075 4085733..4086290 1 NC_002695.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 4086290 916075 ECs4079 Escherichia coli O157:H7 str. Sakai lipopolysaccharide transport periplasmic protein LptA NP_312106.1 4085733 D 386585 CDS NP_312107.1 15833334 916074 4086297..4087022 1 NC_002695.1 similar to YHBG_ECOLI gi|1789593 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4087022 916074 ECs4080 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_312107.1 4086297 D 386585 CDS NP_312108.1 15833335 916073 4087070..4088503 1 NC_002695.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 4088503 916073 ECs4081 Escherichia coli O157:H7 str. Sakai RNA polymerase factor sigma-54 NP_312108.1 4087070 D 386585 CDS NP_312109.1 15833336 916070 4088526..4088813 1 NC_002695.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 4088813 916070 ECs4082 Escherichia coli O157:H7 str. Sakai sigma(54) modulation protein NP_312109.1 4088526 D 386585 CDS NP_312110.1 15833337 916068 4088931..4089422 1 NC_002695.1 similar to PTSN_ECOLI gi|1789597 (conserved in Escherichia coli K-12); PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 4089422 916068 ECs4083 Escherichia coli O157:H7 str. Sakai PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN NP_312110.1 4088931 D 386585 CDS NP_312111.1 15833338 916067 4089468..4090322 1 NC_002695.1 similar to YHBJ_ECOLI gi|1789598 (conserved in Escherichia coli K-12); hypothetical protein 4090322 916067 ECs4084 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312111.1 4089468 D 386585 CDS NP_312112.1 15833339 916066 4090319..4090591 1 NC_002695.1 similar to PTSO_ECOLI gi|1789599 (conserved in Escherichia coli K-12); phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 4090591 916066 ECs4085 Escherichia coli O157:H7 str. Sakai phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) NP_312112.1 4090319 D 386585 CDS NP_312113.1 15833340 916065 4090805..4091437 1 NC_002695.1 similar to YRBL_ECOLI gi|1789600 (conserved in Escherichia coli K-12); hypothetical protein 4091437 916065 ECs4086 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312113.1 4090805 D 386585 CDS NP_312114.1 15833341 916064 complement(4091434..4092162) 1 NC_002695.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 4092162 mtgA 916064 mtgA Escherichia coli O157:H7 str. Sakai monofunctional biosynthetic peptidoglycan transglycosylase NP_312114.1 4091434 R 386585 CDS NP_312115.2 38704149 916063 complement(4092159..4092812) 1 NC_002695.1 similar to YHBL_ECOLI gi|1789602 (conserved in Escherichia coli K-12); isoprenoid biosynthesis protein with amidotransferase-like domain 4092812 916063 ECs4088 Escherichia coli O157:H7 str. Sakai isoprenoid biosynthesis protein with amidotransferase-like domain NP_312115.2 4092159 R 386585 CDS NP_312116.1 15833343 916062 complement(4093042..4095378) 1 NC_002695.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 4095378 916062 ECs4089 Escherichia coli O157:H7 str. Sakai aerobic respiration control sensor protein ArcB NP_312116.1 4093042 R 386585 CDS NP_312117.1 15833344 916061 complement(4095474..4096403) 1 NC_002695.1 similar to YHCC_ECOLI gi|2367204 (conserved in Escherichia coli K-12); hypothetical protein 4096403 916061 ECs4090 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312117.1 4095474 R 386585 CDS NP_312118.1 15833345 916060 4096984..4101537 1 NC_002695.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 4101537 gltB 916060 gltB Escherichia coli O157:H7 str. Sakai glutamate synthase subunit alpha NP_312118.1 4096984 D 386585 CDS NP_312119.1 15833346 916059 4101550..4102968 1 NC_002695.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 4102968 gltD 916059 gltD Escherichia coli O157:H7 str. Sakai glutamate synthase subunit beta NP_312119.1 4101550 D 386585 CDS NP_312120.1 15833347 916058 4103152..4104201 1 NC_002695.1 similar to YHCG_ECOLI gi|1789614 (conserved in Escherichia coli K-12); hypothetical protein 4104201 916058 ECs4093 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312120.1 4103152 D 386585 CDS NP_312121.1 15833348 916057 complement(4104261..4104725) 1 NC_002695.1 similar to YHCH_ECOLI gi|1789615 (conserved in Escherichia coli K-12); hypothetical protein 4104725 916057 ECs4094 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312121.1 4104261 R 386585 CDS NP_312122.2 38704150 916056 complement(4104722..4105597) 1 NC_002695.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 4105597 916056 ECs4095 Escherichia coli O157:H7 str. Sakai N-acetylmannosamine kinase NP_312122.2 4104722 R 386585 CDS NP_312123.1 15833350 916055 complement(4105594..4106283) 1 NC_002695.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 4106283 916055 ECs4096 Escherichia coli O157:H7 str. Sakai N-acetylmannosamine-6-phosphate 2-epimerase NP_312123.1 4105594 R 386585 CDS NP_312124.2 38704151 916054 complement(4106331..4107821) 1 NC_002695.1 similar to NANT_ECOLI gi|1789618 (conserved in Escherichia coli K-12); sialic acid transporter 4107821 916054 ECs4097 Escherichia coli O157:H7 str. Sakai sialic acid transporter NP_312124.2 4106331 R 386585 CDS NP_312125.1 15833352 916053 complement(4107930..4108823) 1 NC_002695.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 4108823 916053 ECs4098 Escherichia coli O157:H7 str. Sakai N-acetylneuraminate lyase NP_312125.1 4107930 R 386585 CDS NP_312126.2 38704152 916052 complement(4108945..4109727) 1 NC_002695.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 4109727 916052 ECs4099 Escherichia coli O157:H7 str. Sakai transcriptional regulator NanR NP_312126.2 4108945 R 386585 CDS NP_312127.1 15833354 916051 4110116..4111480 1 NC_002695.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 4111480 916051 ECs4100 Escherichia coli O157:H7 str. Sakai cryptic C4-dicarboxylate transporter DcuD NP_312127.1 4110116 D 386585 CDS NP_312128.1 15833355 916050 complement(4111515..4112012) 1 NC_002695.1 similar to SSPB_ECOLI gi|1789623 (conserved in Escherichia coli K-12); ClpXP protease specificity-enhancing factor 4112012 916050 ECs4101 Escherichia coli O157:H7 str. Sakai ClpXP protease specificity-enhancing factor NP_312128.1 4111515 R 386585 CDS NP_312129.1 15833356 916049 complement(4112018..4112656) 1 NC_002695.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 4112656 sspA 916049 sspA Escherichia coli O157:H7 str. Sakai stringent starvation protein A NP_312129.1 4112018 R 386585 CDS NP_312130.1 15833357 916048 complement(4113051..4113443) 1 NC_002695.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 4113443 rpsI 916048 rpsI Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S9 NP_312130.1 4113051 R 386585 CDS NP_312131.1 15833358 916047 complement(4113459..4113887) 1 NC_002695.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 4113887 rplM 916047 rplM Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L13 NP_312131.1 4113459 R 386585 CDS NP_312132.1 15833359 916046 complement(4114106..4115233) 1 NC_002695.1 similar to YHCM_ECOLI gi|1789627 (conserved in Escherichia coli K-12); hypothetical protein 4115233 916046 ECs4105 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312132.1 4114106 R 386585 CDS NP_312133.1 15833360 916045 4115421..4115825 1 NC_002695.1 similar to YHCB_ECOLI gi|1789628 (conserved in Escherichia coli K-12); cytochrome d ubiquinol oxidase subunit III 4115825 916045 ECs4106 Escherichia coli O157:H7 str. Sakai cytochrome d ubiquinol oxidase subunit III NP_312133.1 4115421 D 386585 CDS NP_312134.1 15833361 916044 4115979..4117346 1 NC_002695.1 similar to DEGQ_ECOLI gi|1789629 (conserved in Escherichia coli K-12); serine endoprotease 4117346 916044 ECs4107 Escherichia coli O157:H7 str. Sakai serine endoprotease NP_312134.1 4115979 D 386585 CDS NP_312135.1 15833362 916043 4117436..4118503 1 NC_002695.1 similar to DEGS_ECOLI gi|1789630 (conserved in Escherichia coli K-12); serine endoprotease 4118503 916043 ECs4108 Escherichia coli O157:H7 str. Sakai serine endoprotease NP_312135.1 4117436 D 386585 CDS NP_312136.1 15833363 916042 complement(4118567..4119505) 1 NC_002695.1 oxidizes malate to oxaloacetate; malate dehydrogenase 4119505 916042 ECs4109 Escherichia coli O157:H7 str. Sakai malate dehydrogenase NP_312136.1 4118567 R 386585 CDS NP_312137.1 15833364 916041 4119940..4120410 1 NC_002695.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 4120410 916041 ECs4110 Escherichia coli O157:H7 str. Sakai arginine repressor ArgR NP_312137.1 4119940 D 386585 CDS NP_312138.1 15833365 916040 4120724..4121038 1 NC_002695.1 similar to YHCN_ECOLI gi|1789634 (conserved in Escherichia coli K-12); hypothetical protein 4121038 916040 ECs4111 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312138.1 4120724 D 386585 CDS NP_312139.1 15833366 916038 complement(4121094..4121366) 1 NC_002695.1 similar to YHCO_ECOLI gi|1789635 (conserved in Escherichia coli K-12); hypothetical protein 4121366 916038 ECs4112 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312139.1 4121094 R 386585 CDS NP_312140.1 15833367 916037 complement(4121458..4123425) 1 NC_002695.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 4123425 916037 ECs4113 Escherichia coli O157:H7 str. Sakai p-hydroxybenzoic acid efflux subunit AaeB NP_312140.1 4121458 R 386585 CDS NP_312141.1 15833368 916117 complement(4123431..4124360) 1 NC_002695.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 4124360 916117 ECs4114 Escherichia coli O157:H7 str. Sakai p-hydroxybenzoic acid efflux subunit AaeA NP_312141.1 4123431 R 386585 CDS NP_312142.2 162139754 915547 complement(4124368..4124571) 1 NC_002695.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 4124571 915547 ECs4115 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312142.2 4124368 R 386585 CDS NP_312143.1 15833370 916027 4124754..4125683 1 NC_002695.1 similar to YHCS_ECOLI gi|1789639 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator 4125683 916027 ECs4116 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator NP_312143.1 4124754 D 386585 CDS NP_312144.1 15833371 916036 complement(4125817..4127262) 1 NC_002695.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 4127262 tldD 916036 tldD Escherichia coli O157:H7 str. Sakai protease TldD NP_312144.1 4125817 R 386585 CDS NP_312145.1 15833372 916035 complement(4127418..4131218) 1 NC_002695.1 similar to YHDR_ECOLI gi|1789643, YHDP_ECOLI similar to gi|2367206; hypothetical protein 4131218 916035 ECs4118 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312145.1 4127418 R 386585 CDS NP_312146.1 15833373 916034 complement(4131286..4132755) 1 NC_002695.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 4132755 916034 ECs4119 Escherichia coli O157:H7 str. Sakai ribonuclease G NP_312146.1 4131286 R 386585 CDS NP_312147.1 15833374 916033 complement(4132745..4133338) 1 NC_002695.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 4133338 maf 916033 maf Escherichia coli O157:H7 str. Sakai Maf-like protein NP_312147.1 4132745 R 386585 CDS NP_312148.1 15833375 916032 complement(4133347..4133835) 1 NC_002695.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 4133835 916032 ECs4121 Escherichia coli O157:H7 str. Sakai rod shape-determining protein MreD NP_312148.1 4133347 R 386585 CDS NP_312149.1 15833376 916031 complement(4133835..4134938) 1 NC_002695.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 4134938 916031 ECs4122 Escherichia coli O157:H7 str. Sakai rod shape-determining protein MreC NP_312149.1 4133835 R 386585 CDS NP_312150.2 38704153 916030 complement(4135004..4136047) 1 NC_002695.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 4136047 916030 ECs4123 Escherichia coli O157:H7 str. Sakai rod shape-determining protein MreB NP_312150.2 4135004 R 386585 CDS NP_312151.1 15833378 916029 complement(4136352..4138292) 1 NC_002695.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 4138292 916029 ECs4124 Escherichia coli O157:H7 str. Sakai regulatory protein CsrD NP_312151.1 4136352 R 386585 CDS NP_312152.1 15833379 916028 4138444..4139418 1 NC_002695.1 similar to YHDH_ECOLI gi|1789651 (conserved in Escherichia coli K-12); dehydrogenase 4139418 916028 ECs4125 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_312152.1 4138444 D 386585 CDS NP_312154.1 15833381 916025 4140396..4140866 1 NC_002695.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 4140866 916025 ECs4127 Escherichia coli O157:H7 str. Sakai acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_312154.1 4140396 D 386585 CDS NP_312155.1 15833382 916024 4140877..4142226 1 NC_002695.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 4142226 916024 ECs4128 Escherichia coli O157:H7 str. Sakai acetyl-CoA carboxylase biotin carboxylase subunit NP_312155.1 4140877 D 386585 CDS NP_312156.1 15833383 916023 4142335..4142577 1 NC_002695.1 similar to YHDT_ECOLI gi|1789655 (conserved in Escherichia coli K-12); hypothetical protein 4142577 916023 ECs4129 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312156.1 4142335 D 386585 CDS NP_312157.2 38704154 916022 4142567..4144018 1 NC_002695.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 4144018 panF 916022 panF Escherichia coli O157:H7 str. Sakai sodium/panthothenate symporter NP_312157.2 4142567 D 386585 CDS NP_312158.1 15833385 916021 4144030..4144911 1 NC_002695.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 4144911 prmA 916021 prmA Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L11 methyltransferase NP_312158.1 4144030 D 386585 CDS NP_312159.1 15833386 916020 4145240..4146205 1 NC_002695.1 similar to YHDG_ECOLI gi|1789660 (conserved in Escherichia coli K-12); tRNA-dihydrouridine synthase B 4146205 916020 ECs4132 Escherichia coli O157:H7 str. Sakai tRNA-dihydrouridine synthase B NP_312159.1 4145240 D 386585 CDS NP_312160.1 15833387 916019 4146231..4146527 1 NC_002695.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 4146527 fis 916019 fis Escherichia coli O157:H7 str. Sakai DNA-binding protein Fis NP_312160.1 4146231 D 386585 CDS NP_312161.2 38704155 916018 4146612..4147496 1 NC_002695.1 similar to YHDJ_ECOLI gi|1789662 (conserved in Escherichia coli K-12); methyltransferase 4147496 916018 ECs4134 Escherichia coli O157:H7 str. Sakai methyltransferase NP_312161.2 4146612 D 386585 CDS NP_312162.1 15833389 916017 4147580..4147759 1 NC_002695.1 similar to YHAU_ECOLI gi|1789515 (conserved in Escherichia coli K-12); transporter 4147759 916017 ECs4135 Escherichia coli O157:H7 str. Sakai transporter NP_312162.1 4147580 D 386585 CDS NP_312163.1 15833390 916016 complement(4147762..4148424) 1 NC_002695.1 similar to ENVR_ECOLI gi|1789664 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator EnvR 4148424 916016 ECs4136 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator EnvR NP_312163.1 4147762 R 386585 CDS NP_312164.1 15833391 916015 4148823..4149980 1 NC_002695.1 similar to ACRE_ECOLI gi|1789665 (conserved in Escherichia coli K-12); transmembrane protein affects septum formation and cell membrane permeability 4149980 916015 ECs4137 Escherichia coli O157:H7 str. Sakai transmembrane protein affects septum formation and cell membrane permeability NP_312164.1 4148823 D 386585 CDS NP_312167.1 15833394 916012 4153394..4153615 1 NC_002695.1 similar to YHAV_ECOLI gi|1789518 (conserved in Escherichia coli K-12); hypothetical protein 4153615 916012 ECs4140 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312167.1 4153394 D 386585 CDS NP_312168.2 38704156 916011 4154046..4155071 1 NC_002695.1 similar to YHDW_ECOLI gi|1789668 (conserved in Escherichia coli K-12); periplasmic binding transport protein 4155071 916011 ECs4141 Escherichia coli O157:H7 str. Sakai periplasmic binding transport protein NP_312168.2 4154046 D 386585 CDS NP_312169.2 38704157 916010 4155139..4156320 1 NC_002695.1 similar to YHDX_ECOLI gi|1789669 (conserved in Escherichia coli K-12); transport system permease 4156320 916010 ECs4142 Escherichia coli O157:H7 str. Sakai transport system permease NP_312169.2 4155139 D 386585 CDS NP_312170.1 15833397 916009 4156327..4157433 1 NC_002695.1 similar to YHDY_ECOLI gi|1789671 (conserved in Escherichia coli K-12); transport system permease 4157433 916009 ECs4143 Escherichia coli O157:H7 str. Sakai transport system permease NP_312170.1 4156327 D 386585 CDS NP_312171.1 15833398 916008 4157441..4158199 1 NC_002695.1 similar to YHDZ_ECOLI gi|1789672 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4158199 916008 ECs4144 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_312171.1 4157441 D 386585 CDS NP_312172.1 15833399 916001 4164032..4164802 1 NC_002695.1 similar to YRDA_ECOLI gi|1789673 (conserved in Escherichia coli K-12); transferase 4164802 916001 ECs4145 Escherichia coli O157:H7 str. Sakai transferase NP_312172.1 4164032 D 386585 CDS NP_312173.1 15833400 915999 complement(4164778..4165035) 1 NC_002695.1 similar to YRDB_ECOLI gi|1789674 (conserved in Escherichia coli K-12); hypothetical protein 4165035 915999 ECs4146 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312173.1 4164778 R 386585 CDS NP_312174.1 15833401 915998 complement(4165032..4165850) 1 NC_002695.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 4165850 aroE 915998 aroE Escherichia coli O157:H7 str. Sakai shikimate 5-dehydrogenase NP_312174.1 4165032 R 386585 CDS NP_312175.1 15833402 915997 complement(4165855..4166427) 1 NC_002695.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 4166427 915997 ECs4148 Escherichia coli O157:H7 str. Sakai ribosome maturation factor NP_312175.1 4165855 R 386585 CDS NP_312176.1 15833403 915996 complement(4166432..4166737) 1 NC_002695.1 similar to YRDD_ECOLI gi|1789677; hypothetical protein 4166737 915996 ECs4149 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312176.1 4166432 R 386585 CDS NP_312177.1 15833404 915995 complement(4167003..4167476) 1 NC_002695.1 similar to SMG_ECOLI gi|1789679 (conserved in Escherichia coli K-12); hypothetical protein 4167476 915995 ECs4150 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312177.1 4167003 R 386585 CDS NP_312178.1 15833405 915994 complement(4167448..4168572) 1 NC_002695.1 similar to SMF_ECOLI Sp|P30852 (conserved in Escherichia coli K-12); DNA protecting protein DprA 4168572 915994 ECs4151 Escherichia coli O157:H7 str. Sakai DNA protecting protein DprA NP_312178.1 4167448 R 386585 CDS NP_312179.1 15833406 915993 4168702..4169211 1 NC_002695.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 4169211 def 915993 def Escherichia coli O157:H7 str. Sakai peptide deformylase NP_312179.1 4168702 D 386585 CDS NP_312180.1 15833407 915992 4169226..4170173 1 NC_002695.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 4170173 fmt 915992 fmt Escherichia coli O157:H7 str. Sakai methionyl-tRNA formyltransferase NP_312180.1 4169226 D 386585 CDS NP_312181.1 15833408 915991 4170219..4171508 1 NC_002695.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 4171508 915991 ECs4154 Escherichia coli O157:H7 str. Sakai 16S rRNA methyltransferase GidB NP_312181.1 4170219 D 386585 CDS NP_312182.1 15833409 915986 4171530..4172906 1 NC_002695.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 4172906 trkA 915986 trkA Escherichia coli O157:H7 str. Sakai potassium transporter peripheral membrane protein NP_312182.1 4171530 D 386585 CDS NP_312183.1 15833410 915989 4173036..4173446 1 NC_002695.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 4173446 mscL 915989 mscL Escherichia coli O157:H7 str. Sakai large-conductance mechanosensitive channel NP_312183.1 4173036 D 386585 CDS NP_944562.1 38704158 2693746 complement(4173443..4173661) 1 NC_002695.1 hypothetical protein 4173661 2693746 ECs5530 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944562.1 4173443 R 386585 CDS NP_312184.1 15833411 915990 complement(4173717..4174142) 1 NC_002695.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 4174142 zntR 915990 zntR Escherichia coli O157:H7 str. Sakai zinc-responsive transcriptional regulator NP_312184.1 4173717 R 386585 CDS NP_312185.1 15833412 915988 complement(4174153..4174521) 1 NC_002695.1 similar to YHDN_ECOLI gi|1789688 (conserved in Escherichia coli K-12); hypothetical protein 4174521 915988 ECs4158 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312185.1 4174153 R 386585 CDS NP_312186.1 15833413 915985 complement(4174628..4175011) 1 NC_002695.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 4175011 rplQ 915985 rplQ Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L17 NP_312186.1 4174628 R 386585 CDS NP_312187.1 15833414 915984 complement(4175052..4176041) 1 NC_002695.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 4176041 915984 ECs4160 Escherichia coli O157:H7 str. Sakai DNA-directed RNA polymerase subunit alpha NP_312187.1 4175052 R 386585 CDS NP_312188.1 15833415 915983 complement(4176067..4176687) 1 NC_002695.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 4176687 rpsD 915983 rpsD Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S4 NP_312188.1 4176067 R 386585 CDS NP_312189.1 15833416 915982 complement(4176721..4177110) 1 NC_002695.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 4177110 915982 ECs4162 Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S11 NP_312189.1 4176721 R 386585 CDS NP_312190.1 15833417 915981 complement(4177127..4177483) 1 NC_002695.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 4177483 rpsM 915981 rpsM Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S13 NP_312190.1 4177127 R 386585 CDS NP_312191.1 15833418 915980 complement(4177630..4177746) 1 NC_002695.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 4177746 rpmJ 915980 rpmJ Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L36 NP_312191.1 4177630 R 386585 CDS NP_312192.1 15833419 915941 complement(4177778..4179109) 1 NC_002695.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 4179109 secY 915941 secY Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecY NP_312192.1 4177778 R 386585 CDS NP_312193.1 15833420 915945 complement(4179117..4179551) 1 NC_002695.1 late assembly protein; 50S ribosomal protein L15 4179551 rplO 915945 rplO Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L15 NP_312193.1 4179117 R 386585 CDS NP_312194.1 15833421 915946 complement(4179555..4179734) 1 NC_002695.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 4179734 rpmD 915946 rpmD Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L30 NP_312194.1 4179555 R 386585 CDS NP_312195.1 15833422 915963 complement(4179738..4180241) 1 NC_002695.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 4180241 rpsE 915963 rpsE Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S5 NP_312195.1 4179738 R 386585 CDS NP_312196.1 15833423 915979 complement(4180256..4180609) 1 NC_002695.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 4180609 rplR 915979 rplR Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L18 NP_312196.1 4180256 R 386585 CDS NP_312197.1 15833424 915978 complement(4180619..4181152) 1 NC_002695.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 4181152 rplF 915978 rplF Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L6 NP_312197.1 4180619 R 386585 CDS NP_312198.1 15833425 915977 complement(4181165..4181557) 1 NC_002695.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 4181557 rpsH 915977 rpsH Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S8 NP_312198.1 4181165 R 386585 CDS NP_312199.1 15833426 915976 complement(4181591..4181896) 1 NC_002695.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 4181896 rpsN 915976 rpsN Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S14 NP_312199.1 4181591 R 386585 CDS NP_312200.1 15833427 915975 complement(4181911..4182450) 1 NC_002695.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 4182450 rplE 915975 rplE Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L5 NP_312200.1 4181911 R 386585 CDS NP_312201.1 15833428 915974 complement(4182465..4182779) 1 NC_002695.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 4182779 rplX 915974 rplX Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L24 NP_312201.1 4182465 R 386585 CDS NP_312202.1 15833429 915973 complement(4182790..4183161) 1 NC_002695.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 4183161 rplN 915973 rplN Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L14 NP_312202.1 4182790 R 386585 CDS NP_312203.1 15833430 915972 complement(4183326..4183580) 1 NC_002695.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 4183580 rpsQ 915972 rpsQ Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S17 NP_312203.1 4183326 R 386585 CDS NP_312204.1 15833431 915971 complement(4183580..4183771) 1 NC_002695.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 4183771 rpmC 915971 rpmC Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L29 NP_312204.1 4183580 R 386585 CDS NP_312205.1 15833432 915970 complement(4183771..4184181) 1 NC_002695.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 4184181 rplP 915970 rplP Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L16 NP_312205.1 4183771 R 386585 CDS NP_312206.1 15833433 915969 complement(4184194..4184895) 1 NC_002695.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 4184895 rpsC 915969 rpsC Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S3 NP_312206.1 4184194 R 386585 CDS NP_312207.1 15833434 915968 complement(4184913..4185245) 1 NC_002695.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 4185245 rplV 915968 rplV Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L22 NP_312207.1 4184913 R 386585 CDS NP_312208.1 15833435 915967 complement(4185260..4185538) 1 NC_002695.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 4185538 rpsS 915967 rpsS Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S19 NP_312208.1 4185260 R 386585 CDS NP_312209.1 15833436 915966 complement(4185555..4186376) 1 NC_002695.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 4186376 rplB 915966 rplB Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L2 NP_312209.1 4185555 R 386585 CDS NP_312210.1 15833437 915965 complement(4186394..4186696) 1 NC_002695.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 4186696 rplW 915965 rplW Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L23 NP_312210.1 4186394 R 386585 CDS NP_312211.1 15833438 915964 complement(4186693..4187298) 1 NC_002695.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 4187298 rplD 915964 rplD Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L4 NP_312211.1 4186693 R 386585 CDS NP_312212.1 15833439 915962 complement(4187309..4187938) 1 NC_002695.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 4187938 rplC 915962 rplC Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L3 NP_312212.1 4187309 R 386585 CDS NP_312213.1 15833440 915961 complement(4187971..4188282) 1 NC_002695.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 4188282 rpsJ 915961 rpsJ Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S10 NP_312213.1 4187971 R 386585 CDS NP_312214.1 15833441 915960 4188427..4188612 1 NC_002695.1 hypothetical protein 4188612 915960 ECs4187 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312214.1 4188427 D 386585 CDS NP_312215.1 15833442 915959 4188661..4189128 1 NC_002695.1 similar to leader peptidases e.g. HopD (strain ECOR30) [Escherichia coli] gi|7674073|sp|O68932, (LT2) [Salmonella typhimurium] gi|7674072|sp|O68927; HopD 4189128 915959 ECs4188 Escherichia coli O157:H7 str. Sakai HopD NP_312215.1 4188661 D 386585 CDS NP_312216.1 15833443 915958 complement(4189125..4189601) 1 NC_002695.1 iron storage protein; bacterioferritin 4189601 915958 ECs4189 Escherichia coli O157:H7 str. Sakai bacterioferritin NP_312216.1 4189125 R 386585 CDS NP_944563.1 38704159 2693826 complement(4189674..4189868) 1 NC_002695.1 bacterioferritin-associated ferredoxin 4189868 2693826 ECs5531 Escherichia coli O157:H7 str. Sakai bacterioferritin-associated ferredoxin NP_944563.1 4189674 R 386585 CDS NP_312217.1 15833444 915957 complement(4190051..4191235) 1 NC_002695.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4191235 tuf 915957 tuf Escherichia coli O157:H7 str. Sakai elongation factor Tu NP_312217.1 4190051 R 386585 CDS NP_312218.1 15833445 915956 complement(4191306..4193420) 1 NC_002695.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 4193420 915956 ECs4191 Escherichia coli O157:H7 str. Sakai elongation factor G NP_312218.1 4191306 R 386585 CDS NP_312219.1 15833446 915955 complement(4193517..4193987) 1 NC_002695.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 4193987 915955 ECs4192 Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S7 NP_312219.1 4193517 R 386585 CDS NP_312220.1 15833447 915954 complement(4194084..4194458) 1 NC_002695.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 4194458 rpsL 915954 rpsL Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S12 NP_312220.1 4194084 R 386585 CDS NP_312221.1 15833448 915953 complement(4194584..4194871) 1 NC_002695.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 4194871 915953 ECs4194 Escherichia coli O157:H7 str. Sakai sulfur transfer complex subunit TusB NP_312221.1 4194584 R 386585 CDS NP_312222.1 15833449 915952 complement(4194879..4195238) 1 NC_002695.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 4195238 915952 ECs4195 Escherichia coli O157:H7 str. Sakai sulfur relay protein TusC NP_312222.1 4194879 R 386585 CDS NP_312223.1 15833450 915951 complement(4195238..4195624) 1 NC_002695.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 4195624 915951 ECs4196 Escherichia coli O157:H7 str. Sakai sulfur transfer complex subunit TusD NP_312223.1 4195238 R 386585 CDS NP_312224.2 38704160 915950 complement(4195624..4196346) 1 NC_002695.1 similar to YHEO_ECOLI gi|1789744 (conserved in Escherichia coli K-12); hypothetical protein 4196346 915950 ECs4197 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312224.2 4195624 R 386585 CDS NP_312225.1 15833452 915949 complement(4196513..4197325) 1 NC_002695.1 rotamase; FKBP-type peptidylprolyl isomerase 4197325 915949 ECs4198 Escherichia coli O157:H7 str. Sakai FKBP-type peptidylprolyl isomerase NP_312225.1 4196513 R 386585 CDS NP_312226.1 15833453 915948 4197546..4197764 1 NC_002695.1 similar to SLYX_ECOLI gi|1789747 (conserved in Escherichia coli K-12); hypothetical protein 4197764 915948 ECs4199 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312226.1 4197546 D 386585 CDS NP_312227.1 15833454 915947 complement(4197813..4198403) 1 NC_002695.1 rotamase; FKBP-type peptidylprolyl isomerase 4198403 915947 ECs4200 Escherichia coli O157:H7 str. Sakai FKBP-type peptidylprolyl isomerase NP_312227.1 4197813 R 386585 CDS NP_944564.1 38704161 2693827 complement(4198498..4198698) 1 NC_002695.1 hypothetical protein 4198698 2693827 ECs5532 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944564.1 4198498 R 386585 CDS NP_312228.1 15833455 915944 complement(4198735..4200513) 1 NC_002695.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 4200513 915944 ECs4201 Escherichia coli O157:H7 str. Sakai glutathione-regulated potassium-efflux system protein KefB NP_312228.1 4198735 R 386585 CDS NP_312229.1 15833456 915943 complement(4200513..4201067) 1 NC_002695.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 4201067 915943 ECs4202 Escherichia coli O157:H7 str. Sakai glutathione-regulated potassium-efflux system ancillary protein KefG NP_312229.1 4200513 R 386585 CDS NP_312230.1 15833457 915942 4201195..4203108 1 NC_002695.1 similar to YHES_ECOLI gi|1789751 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4203108 915942 ECs4203 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_312230.1 4201195 D 386585 CDS NP_312231.1 15833458 915940 4203108..4204130 1 NC_002695.1 similar to YHET_ECOLI gi|1789752 (conserved in Escherichia coli K-12); hydrolase 4204130 915940 ECs4204 Escherichia coli O157:H7 str. Sakai hydrolase NP_312231.1 4203108 D 386585 CDS NP_312232.1 15833459 915939 4204124..4204342 1 NC_002695.1 similar to YHEU_ECOLI gi|1789753 (conserved in Escherichia coli K-12); hypothetical protein 4204342 915939 ECs4205 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312232.1 4204124 D 386585 CDS NP_312233.1 15833460 915938 4204396..4205265 1 NC_002695.1 similar to PRKB_ECOLI gi|2367214 (conserved in Escherichia coli K-12); phosphoribulokinase 4205265 915938 ECs4206 Escherichia coli O157:H7 str. Sakai phosphoribulokinase NP_312233.1 4204396 D 386585 CDS NP_312234.1 15833461 915937 complement(4205320..4205724) 1 NC_002695.1 similar to YHFA_ECOLI gi|1789755 (conserved in Escherichia coli K-12); hypothetical protein 4205724 915937 ECs4207 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312234.1 4205320 R 386585 CDS NP_312235.1 15833462 915936 4206026..4206658 1 NC_002695.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 4206658 915936 ECs4208 Escherichia coli O157:H7 str. Sakai cAMP-regulatory protein NP_312235.1 4206026 D 386585 CDS NP_312236.1 15833463 915935 4206709..4208799 1 NC_002695.1 similar to YHFK_ECOLI gi|1789757 (conserved in Escherichia coli K-12); hypothetical protein 4208799 915935 ECs4209 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312236.1 4206709 D 386585 CDS NP_312237.1 15833464 915934 complement(4208866..4210086) 1 NC_002695.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 4210086 argD 915934 argD Escherichia coli O157:H7 str. Sakai bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase NP_312237.1 4208866 R 386585 CDS NP_312238.1 15833465 915933 complement(4210172..4210735) 1 NC_002695.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 4210735 915933 ECs4211 Escherichia coli O157:H7 str. Sakai para-aminobenzoate synthase component II NP_312238.1 4210172 R 386585 CDS NP_312239.1 15833466 915932 complement(4210767..4211369) 1 NC_002695.1 induced in stationary phase; recognized by rpoS; affects cell division; similar to FIC_ECOLI gi|1789761 (conserved in Escherichia coli K-12); cell filamentation protein Fic 4211369 915932 ECs4212 Escherichia coli O157:H7 str. Sakai cell filamentation protein Fic NP_312239.1 4210767 R 386585 CDS NP_312240.1 15833467 915931 complement(4211359..4211526) 1 NC_002695.1 similar to YHFG_ECOLI gi|1789762 (conserved in Escherichia coli K-12); hypothetical protein 4211526 915931 ECs4213 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312240.1 4211359 R 386585 CDS NP_312241.1 15833468 915930 complement(4211631..4212203) 1 NC_002695.1 similar to PPIA_ECOLI gi|1789763 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase A 4212203 915930 ECs4214 Escherichia coli O157:H7 str. Sakai peptidyl-prolyl cis-trans isomerase A NP_312241.1 4211631 R 386585 CDS NP_312242.1 15833469 915929 4212474..4213655 1 NC_002695.1 similar to YHFC_ECOLI gi|1789764 (conserved in Escherichia coli K-12); hypothetical protein 4213655 915929 ECs4215 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312242.1 4212474 D 386585 CDS NP_312243.1 15833470 915928 4213917..4216460 1 NC_002695.1 similar to NIRB_ECOLI gi|1789765 (conserved in Escherichia coli K-12); nitrite reductase (NAD(P)H) subunit 4216460 915928 ECs4216 Escherichia coli O157:H7 str. Sakai nitrite reductase (NAD(P)H) subunit NP_312243.1 4213917 D 386585 CDS NP_312244.1 15833471 915916 4216457..4216783 1 NC_002695.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 4216783 nirD 915916 nirD Escherichia coli O157:H7 str. Sakai nitrite reductase small subunit NP_312244.1 4216457 D 386585 CDS NP_312245.2 38704162 915909 4216909..4217715 1 NC_002695.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 4217715 915909 ECs4218 Escherichia coli O157:H7 str. Sakai nitrite transporter NirC NP_312245.2 4216909 D 386585 CDS NP_312246.1 15833473 915926 4217734..4219107 1 NC_002695.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 4219107 cysG 915926 cysG Escherichia coli O157:H7 str. Sakai siroheme synthase NP_312246.1 4217734 D 386585 CDS NP_312247.1 15833474 915927 4219362..4219529 1 NC_002695.1 similar to YHFL_ECOLI gi|1789770 (conserved in Escherichia coli K-12); hypothetical protein 4219529 915927 ECs4220 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312247.1 4219362 D 386585 CDS NP_312248.1 15833475 915924 4219774..4221162 1 NC_002695.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 4221162 frlA 915924 frlA Escherichia coli O157:H7 str. Sakai fructoselysine transporter NP_312248.1 4219774 D 386585 CDS NP_312249.1 15833476 915923 4221162..4222205 1 NC_002695.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 4222205 frlB 915923 frlB Escherichia coli O157:H7 str. Sakai fructoselysine-6-P-deglycase NP_312249.1 4221162 D 386585 CDS NP_312250.1 15833477 915922 4222256..4223083 1 NC_002695.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 4223083 915922 ECs4223 Escherichia coli O157:H7 str. Sakai fructoselysine 3-epimerase NP_312250.1 4222256 D 386585 CDS NP_312251.1 15833478 915921 4223083..4223415 1 NC_002695.1 similar to YHFQ_ECOLI gi|1789775 (conserved in Escherichia coli K-12); hypothetical protein 4223415 915921 ECs4224 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312251.1 4223083 D 386585 CDS NP_312252.3 162139722 915920 4223902..4224699 1 NC_002695.1 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 4224699 915920 ECs4225 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator FrlR NP_312252.3 4223902 D 386585 CDS NP_312253.1 15833480 915919 complement(4224830..4225834) 1 NC_002695.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 4225834 915919 ECs4226 Escherichia coli O157:H7 str. Sakai tryptophanyl-tRNA synthetase NP_312253.1 4224830 R 386585 CDS NP_312254.1 15833481 915918 complement(4225827..4226585) 1 NC_002695.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 4226585 915918 ECs4227 Escherichia coli O157:H7 str. Sakai phosphoglycolate phosphatase NP_312254.1 4225827 R 386585 CDS NP_312255.1 15833482 915917 complement(4226578..4227255) 1 NC_002695.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 4227255 915917 ECs4228 Escherichia coli O157:H7 str. Sakai ribulose-phosphate 3-epimerase NP_312255.1 4226578 R 386585 CDS NP_312256.1 15833483 915915 complement(4227273..4228109) 1 NC_002695.1 similar to DAM_ECOLI gi|1789789 (conserved in Escherichia coli K-12); DNA adenine methylase 4228109 915915 ECs4229 Escherichia coli O157:H7 str. Sakai DNA adenine methylase NP_312256.1 4227273 R 386585 CDS NP_312257.1 15833484 915914 complement(4228216..4229502) 1 NC_002695.1 membrane protein ; similar to DAMX_ECOLI gi|1789790 (conserved in Escherichia coli K-12); hypothetical protein 4229502 915914 ECs4230 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312257.1 4228216 R 386585 CDS NP_312258.1 15833485 915913 complement(4229594..4230682) 1 NC_002695.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 4230682 aroB 915913 aroB Escherichia coli O157:H7 str. Sakai 3-dehydroquinate synthase NP_312258.1 4229594 R 386585 CDS NP_312259.2 162139753 915912 complement(4230739..4231260) 1 NC_002695.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 4231260 aroK 915912 aroK Escherichia coli O157:H7 str. Sakai shikimate kinase I NP_312259.2 4230739 R 386585 CDS NP_312260.1 15833487 915911 complement(4231661..4232899) 1 NC_002695.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 4232899 hofQ 915911 hofQ Escherichia coli O157:H7 str. Sakai outer membrane porin HofQ NP_312260.1 4231661 R 386585 CDS NP_312261.2 38704164 915910 complement(4232811..4233215) 1 NC_002695.1 similar to YRFA_ECOLI gi|1789794 (conserved in Escherichia coli K-12); hypothetical protein 4233215 915910 ECs4234 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312261.2 4232811 R 386585 CDS NP_312262.1 15833489 915908 complement(4233205..4233645) 1 NC_002695.1 similar to YRFB_ECOLI gi|1789795 (conserved in Escherichia coli K-12); hypothetical protein 4233645 915908 ECs4235 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312262.1 4233205 R 386585 CDS NP_312263.1 15833490 915898 complement(4233629..4234168) 1 NC_002695.1 similar to YRFC_ECOLI gi|1789796 (conserved in Escherichia coli K-12); hypothetical protein 4234168 915898 ECs4236 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312263.1 4233629 R 386585 CDS NP_312264.1 15833491 915902 complement(4234152..4234946) 1 NC_002695.1 similar to YRFD_ECOLI gi|1789797 (conserved in Escherichia coli K-12); hypothetical protein 4234946 915902 ECs4237 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312264.1 4234152 R 386585 CDS NP_312265.2 229544779 915905 4235066..4237618 1 NC_002695.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4237618 mrcA 915905 mrcA Escherichia coli O157:H7 str. Sakai peptidoglycan synthetase NP_312265.2 4235066 D 386585 CDS NP_312266.1 15833493 915907 complement(4237783..4238343) 1 NC_002695.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 4238343 nudE 915907 nudE Escherichia coli O157:H7 str. Sakai ADP-ribose diphosphatase NudE NP_312266.1 4237783 R 386585 CDS NP_312267.1 15833494 915906 4238663..4240798 1 NC_002695.1 similar to YRFF_ECOLI gi|1789801 (conserved in Escherichia coli K-12); dehydrogenase 4240798 915906 ECs4240 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_312267.1 4238663 D 386585 CDS NP_312268.2 38704165 915904 4240863..4241531 1 NC_002695.1 similar to YRFG_ECOLI gi|1789802 (conserved in Escherichia coli K-12); phosphatase 4241531 915904 ECs4241 Escherichia coli O157:H7 str. Sakai phosphatase NP_312268.2 4240863 D 386585 CDS NP_312269.1 15833496 915903 4241542..4241943 1 NC_002695.1 similar to HSLR_ECOLI gi|1176866|sp|P45802 (conserved in Escherichia coli K-12); ribosome-associated heat shock protein Hsp15 4241943 915903 ECs4242 Escherichia coli O157:H7 str. Sakai ribosome-associated heat shock protein Hsp15 NP_312269.1 4241542 D 386585 CDS NP_312270.3 162139723 915901 4241968..4242846 1 NC_002695.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 4242846 hslO 915901 hslO Escherichia coli O157:H7 str. Sakai Hsp33-like chaperonin NP_312270.3 4241968 D 386585 CDS NP_312271.1 15833498 915900 complement(4242909..4244633) 1 NC_002695.1 similar to YHGE_ECOLI gi|1789805 (conserved in Escherichia coli K-12); transport 4244633 915900 ECs4244 Escherichia coli O157:H7 str. Sakai transport NP_312271.1 4242909 R 386585 CDS NP_312272.1 15833499 915899 4245012..4246634 1 NC_002695.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4246634 915899 ECs4245 Escherichia coli O157:H7 str. Sakai phosphoenolpyruvate carboxykinase NP_312272.1 4245012 D 386585 CDS NP_312273.1 15833500 915897 complement(4246710..4248062) 1 NC_002695.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 4248062 envZ 915897 envZ Escherichia coli O157:H7 str. Sakai osmolarity sensor protein NP_312273.1 4246710 R 386585 CDS NP_312274.1 15833501 915896 complement(4248059..4248778) 1 NC_002695.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 4248778 ompR 915896 ompR Escherichia coli O157:H7 str. Sakai osmolarity response regulator NP_312274.1 4248059 R 386585 CDS NP_312275.2 162139752 915895 4249006..4249482 1 NC_002695.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4249482 greB 915895 greB Escherichia coli O157:H7 str. Sakai transcription elongation factor GreB NP_312275.2 4249006 D 386585 CDS NP_312276.1 15833503 915894 4249678..4251900 1 NC_002695.1 similar to YHGF_ECOLI gi|1789811 (conserved in Escherichia coli K-12); hypothetical protein 4251900 915894 ECs4249 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312276.1 4249678 D 386585 CDS NP_312277.1 15833504 915893 4252338..4252565 1 NC_002695.1 similar to FEOA_ECOLI gi|1789812 (conserved in Escherichia coli K-12); ferrous iron transport protein A 4252565 feoA 915893 feoA Escherichia coli O157:H7 str. Sakai ferrous iron transport protein A NP_312277.1 4252338 D 386585 CDS NP_312278.1 15833505 915892 4252582..4254903 1 NC_002695.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4254903 feoB 915892 feoB Escherichia coli O157:H7 str. Sakai ferrous iron transport protein B NP_312278.1 4252582 D 386585 CDS NP_312279.1 15833506 915891 4254903..4255139 1 NC_002695.1 similar to YHGG_ECOLI gi|1789814 (conserved in Escherichia coli K-12); hypothetical protein 4255139 915891 ECs4252 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312279.1 4254903 D 386585 CDS NP_312280.1 15833507 915890 4255342..4256220 1 NC_002695.1 similar to YHGA_ECOLI gi|1789816 (conserved in Escherichia coli K-12); hypothetical protein 4256220 915890 ECs4253 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312280.1 4255342 D 386585 CDS NP_312281.1 15833508 915889 complement(4256247..4257017) 1 NC_002695.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 4257017 915889 ECs4255 Escherichia coli O157:H7 str. Sakai carboxylesterase BioH NP_312281.1 4256247 R 386585 CDS NP_312282.2 162139751 915887 4257055..4257738 1 NC_002695.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4257738 915887 ECs4254 Escherichia coli O157:H7 str. Sakai gluconate periplasmic binding protein NP_312282.2 4257055 D 386585 CDS NP_312283.1 15833510 915886 4257797..4258372 1 NC_002695.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 4258372 915886 ECs4256 Escherichia coli O157:H7 str. Sakai DNA uptake protein NP_312283.1 4257797 D 386585 CDS NP_312284.1 15833511 915875 4258733..4260049 1 NC_002695.1 similar to GNTT_ECOLI gi|1789820 (conserved in Escherichia coli K-12); gluconate permease 4260049 915875 ECs4257 Escherichia coli O157:H7 str. Sakai gluconate permease NP_312284.1 4258733 D 386585 CDS NP_312285.1 15833512 915883 complement(4260094..4262178) 1 NC_002695.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 4262178 malQ 915883 malQ Escherichia coli O157:H7 str. Sakai 4-alpha-glucanotransferase NP_312285.1 4260094 R 386585 CDS NP_312286.1 15833513 915885 complement(4262188..4264581) 1 NC_002695.1 similar to MALP_ECOLI gi|2367221 (conserved in Escherichia coli K-12); maltodextrin phosphorylase 4264581 915885 ECs4259 Escherichia coli O157:H7 str. Sakai maltodextrin phosphorylase NP_312286.1 4262188 R 386585 CDS NP_312287.1 15833514 915884 4265193..4267898 1 NC_002695.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 4267898 915884 ECs4260 Escherichia coli O157:H7 str. Sakai transcriptional regulator MalT NP_312287.1 4265193 D 386585 CDS NP_312288.1 15833515 915882 4267959..4268243 1 NC_002695.1 similar to hypothetical protein [Xylella fastidiosa] gi|9112262|gb|AAF85593.1|AE003851_24; hypothetical protein 4268243 915882 ECs4261 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312288.1 4267959 D 386585 CDS NP_312289.1 15833516 915881 4268234..4268719 1 NC_002695.1 similar to hypothetical protein [Xylella fastidiosa] gi|9112263|gb|AAF85594.1|AE003851_25; hypothetical protein 4268719 915881 ECs4262 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312289.1 4268234 D 386585 CDS NP_312290.1 15833517 915880 complement(4268769..4269800) 1 NC_002695.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 4269800 915880 ECs4263 Escherichia coli O157:H7 str. Sakai RNA 3'-terminal-phosphate cyclase NP_312290.1 4268769 R 386585 CDS NP_312291.1 15833518 915879 complement(4269801..4271027) 1 NC_002695.1 similar to RTCB_ECOLI gi|2367224 (conserved in Escherichia coli K-12); hypothetical protein 4271027 915879 ECs4264 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312291.1 4269801 R 386585 CDS NP_312292.1 15833519 915878 4271215..4272813 1 NC_002695.1 similar to RTCR_ECOLI gi|1789828 (conserved in Escherichia coli K-12); 2-component regulator 4272813 915878 ECs4265 Escherichia coli O157:H7 str. Sakai 2-component regulator NP_312292.1 4271215 D 386585 CDS NP_312293.1 15833520 915877 complement(4272795..4273553) 1 NC_002695.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 4273553 915877 ECs4266 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor GlpR NP_312293.1 4272795 R 386585 CDS NP_312294.1 15833521 915876 complement(4273570..4274400) 1 NC_002695.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 4274400 915876 ECs4267 Escherichia coli O157:H7 str. Sakai intramembrane serine protease GlpG NP_312294.1 4273570 R 386585 CDS NP_312295.1 15833522 915874 complement(4274445..4274771) 1 NC_002695.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 4274771 glpE 915874 glpE Escherichia coli O157:H7 str. Sakai thiosulfate sulfurtransferase NP_312295.1 4274445 R 386585 CDS NP_312296.1 15833523 915873 4274961..4276466 1 NC_002695.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4276466 glpD 915873 glpD Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate dehydrogenase NP_312296.1 4274961 D 386585 CDS NP_312297.1 15833524 915872 complement(4276681..4277280) 1 NC_002695.1 hypothetical protein 4277280 915872 ECs4270 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312297.1 4276681 R 386585 CDS NP_312298.1 15833525 915856 complement(4277283..4278275) 1 NC_002695.1 similar to binding proteins e.g. phosphate-binding protein PstS homolog [Methanobacterium thermoautotrophicum (strain Delta H)] gi|7442891|pir||A69098; ABC transporter ATP-binding protein 4278275 915856 ECs4271 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_312298.1 4277283 R 386585 CDS NP_312299.1 15833526 915865 complement(4278301..4279818) 1 NC_002695.1 similar to YZGL_ECOLI gi|1789834, phosphate-binding proteins PstS homolog; hypothetical protein 4279818 915865 ECs4272 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312299.1 4278301 R 386585 CDS NP_312300.1 15833527 915866 complement(4279934..4282381) 1 NC_002695.1 similar to GLGP_ECOLI gi|2367228 (conserved in Escherichia coli K-12); glycogen phosphorylase 4282381 915866 ECs4273 Escherichia coli O157:H7 str. Sakai glycogen phosphorylase NP_312300.1 4279934 R 386585 CDS NP_312301.1 15833528 915868 complement(4282400..4283833) 1 NC_002695.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 4283833 glgA 915868 glgA Escherichia coli O157:H7 str. Sakai glycogen synthase NP_312301.1 4282400 R 386585 CDS NP_312302.1 15833529 915871 complement(4283833..4285128) 1 NC_002695.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 4285128 glgC 915871 glgC Escherichia coli O157:H7 str. Sakai glucose-1-phosphate adenylyltransferase NP_312302.1 4283833 R 386585 CDS NP_312303.1 15833530 915870 complement(4285146..4287119) 1 NC_002695.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein 4287119 915870 ECs4276 Escherichia coli O157:H7 str. Sakai glycogen debranching protein NP_312303.1 4285146 R 386585 CDS NP_312304.1 15833531 915869 complement(4287116..4289302) 1 NC_002695.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 4289302 915869 ECs4277 Escherichia coli O157:H7 str. Sakai glycogen branching protein NP_312304.1 4287116 R 386585 CDS NP_312305.1 15833532 915867 complement(4289575..4290678) 1 NC_002695.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4290678 915867 ECs4278 Escherichia coli O157:H7 str. Sakai aspartate-semialdehyde dehydrogenase NP_312305.1 4289575 R 386585 CDS NP_312306.1 15833533 915864 4290870..4291463 1 NC_002695.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 4291463 915864 ECs4279 Escherichia coli O157:H7 str. Sakai dITP- and XTP- hydrolase NP_312306.1 4290870 D 386585 CDS NP_312307.1 15833534 915863 complement(4291509..4292711) 1 NC_002695.1 similar to DNA processing chain A (Smf protein), e.g. [Neisseria meningitidis] gi|7378929|emb|CAB83472.1|; DNA processing protein DprA 4292711 915863 ECs4280 Escherichia coli O157:H7 str. Sakai DNA processing protein DprA NP_312307.1 4291509 R 386585 CDS NP_312312.1 15833539 915858 complement(4294975..4296315) 1 NC_002695.1 similar to GNTU_1_ECOLI gi|1789844, GNTU_ECOLI SW: P46858; low affinity gluconate transporter 4296315 915858 ECs4285 Escherichia coli O157:H7 str. Sakai low affinity gluconate transporter NP_312312.1 4294975 R 386585 CDS NP_312313.2 162139750 915857 complement(4296319..4296846) 1 NC_002695.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 4296846 gntK 915857 gntK Escherichia coli O157:H7 str. Sakai gluconate kinase NP_312313.2 4296319 R 386585 CDS NP_312314.1 15833541 915855 complement(4296985..4297980) 1 NC_002695.1 similar to GNTR_ECOLI gi|1789846 (conserved in Escherichia coli K-12); regulator of gluconate operon 4297980 915855 ECs4287 Escherichia coli O157:H7 str. Sakai regulator of gluconate operon NP_312314.1 4296985 R 386585 CDS NP_312315.1 15833542 915854 complement(4298204..4298899) 1 NC_002695.1 similar to YHHW_ECOLI gi|1789847 (conserved in Escherichia coli K-12); hypothetical protein 4298899 915854 ECs4288 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312315.1 4298204 R 386585 CDS NP_312316.1 15833543 915853 complement(4299022..4300059) 1 NC_002695.1 similar to YHHX_ECOLI gi|1789848 (conserved in Escherichia coli K-12); dehydrogenase 4300059 915853 ECs4289 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_312316.1 4299022 R 386585 CDS NP_312317.1 15833544 915852 4300393..4300881 1 NC_002695.1 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 4300881 915852 ECs4290 Escherichia coli O157:H7 str. Sakai acetyltransferase YhhY NP_312317.1 4300393 D 386585 CDS NP_312318.1 15833545 915851 4301092..4302003 1 NC_002695.1 hypothetical protein 4302003 915851 ECs4291 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312318.1 4301092 D 386585 CDS NP_312319.1 15833546 915850 complement(4301952..4302368) 1 NC_002695.1 hypothetical protein 4302368 915850 ECs4292 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312319.1 4301952 R 386585 CDS NP_312320.1 15833547 915849 complement(4302737..4304482) 1 NC_002695.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 4304482 ggt 915849 ggt Escherichia coli O157:H7 str. Sakai gamma-glutamyltranspeptidase NP_312320.1 4302737 R 386585 CDS NP_312321.1 15833548 915831 4304602..4305042 1 NC_002695.1 similar to YHHA_ECOLI gi|1789857 (conserved in Escherichia coli K-12); hypothetical protein 4305042 915831 ECs4294 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312321.1 4304602 D 386585 CDS NP_312322.1 15833549 915833 complement(4305029..4305772) 1 NC_002695.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 4305772 ugpQ 915833 ugpQ Escherichia coli O157:H7 str. Sakai glycerophosphodiester phosphodiesterase NP_312322.1 4305029 R 386585 CDS NP_312323.2 38704167 915835 complement(4305769..4306839) 1 NC_002695.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding protein 4306839 ugpC 915835 ugpC Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate transporter ATP-binding protein NP_312323.2 4305769 R 386585 CDS NP_312324.1 15833551 915845 complement(4306841..4307686) 1 NC_002695.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 4307686 915845 ECs4297 Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate transporter membrane protein NP_312324.1 4306841 R 386585 CDS NP_312325.1 15833552 915848 complement(4307683..4308570) 1 NC_002695.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 4308570 915848 ECs4298 Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate transporter permease NP_312325.1 4307683 R 386585 CDS NP_312326.1 15833553 915847 complement(4308668..4309984) 1 NC_002695.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 4309984 915847 ECs4299 Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate transporter periplasmic binding protein NP_312326.1 4308668 R 386585 CDS NP_312327.1 15833554 915846 complement(4310344..4311090) 1 NC_002695.1 hypothetical protein 4311090 915846 ECs4300 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312327.1 4310344 R 386585 CDS NP_312328.2 38704168 915844 complement(4311209..4311922) 1 NC_002695.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding protein 4311922 livF 915844 livF Escherichia coli O157:H7 str. Sakai leucine/isoleucine/valine transporter ATP-binding protein NP_312328.2 4311209 R 386585 CDS NP_312329.1 15833556 915843 complement(4311924..4312691) 1 NC_002695.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding protein 4312691 livG 915843 livG Escherichia coli O157:H7 str. Sakai leucine/isoleucine/valine transporter ATP-binding protein NP_312329.1 4311924 R 386585 CDS NP_312330.1 15833557 915842 complement(4312688..4313965) 1 NC_002695.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease 4313965 livM 915842 livM Escherichia coli O157:H7 str. Sakai leucine/isoleucine/valine transporter permease NP_312330.1 4312688 R 386585 CDS NP_312331.1 15833558 915841 complement(4313962..4314888) 1 NC_002695.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease LivH 4314888 915841 ECs4304 Escherichia coli O157:H7 str. Sakai branched-chain amino acid transporter permease LivH NP_312331.1 4313962 R 386585 CDS NP_312332.1 15833559 915840 complement(4314936..4316045) 1 NC_002695.1 similar to LIVJ_ECOLI gi|1789870 (conserved in Escherichia coli K-12); periplasmic binding protein of high-affinity leucine-specific transport system 4316045 915840 ECs4305 Escherichia coli O157:H7 str. Sakai periplasmic binding protein of high-affinity leucine-specific transport system NP_312332.1 4314936 R 386585 CDS NP_312333.1 15833560 915839 4316469..4316852 1 NC_002695.1 similar to YHHK_ECOLI gi|1789869 (conserved in Escherichia coli K-12); hypothetical protein 4316852 915839 ECs4306 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312333.1 4316469 D 386585 CDS NP_312334.1 15833561 915838 complement(4316849..4317376) 1 NC_002695.1 similar to hypothetical protein ORF79 [Escherichia coli plasmid pB171] gi|6009455|dbj|BAA84914.1; hypothetical protein 4317376 915838 ECs4307 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312334.1 4316849 R 386585 CDS NP_312335.1 15833562 915837 complement(4317383..4317649) 1 NC_002695.1 similar to hypothetical protein ORF80 [Escherichia coli plasmid pB171]; hypothetical protein 4317649 915837 ECs4308 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312335.1 4317383 R 386585 CDS NP_312336.1 15833563 915836 complement(4317799..4318959) 1 NC_002695.1 similar to LIVJ_ECOLI gi|1789870 (conserved in Escherichia coli K-12); periplasmic binding protein of high-affinity amino acid transport system 4318959 915836 ECs4309 Escherichia coli O157:H7 str. Sakai periplasmic binding protein of high-affinity amino acid transport system NP_312336.1 4317799 R 386585 CDS NP_312337.1 15833564 915834 complement(4319173..4320027) 1 NC_002695.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 4320027 915834 ECs4310 Escherichia coli O157:H7 str. Sakai RNA polymerase factor sigma-32 NP_312337.1 4319173 R 386585 CDS NP_312338.1 15833565 915832 complement(4320272..4321330) 1 NC_002695.1 ABC transporter, membrane protein; cell division protein FtsX 4321330 ftsX 915832 ftsX Escherichia coli O157:H7 str. Sakai cell division protein FtsX NP_312338.1 4320272 R 386585 CDS NP_312339.1 15833566 915830 complement(4321323..4321991) 1 NC_002695.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 4321991 915830 ECs4312 Escherichia coli O157:H7 str. Sakai cell division protein FtsE NP_312339.1 4321323 R 386585 CDS NP_312340.1 15833567 915829 complement(4321994..4323490) 1 NC_002695.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 4323490 915829 ECs4313 Escherichia coli O157:H7 str. Sakai cell division protein FtsY NP_312340.1 4321994 R 386585 CDS NP_312341.1 15833568 915816 4323640..4324236 1 NC_002695.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4324236 rsmD 915816 rsmD Escherichia coli O157:H7 str. Sakai 16S rRNA m(2)G966-methyltransferase NP_312341.1 4323640 D 386585 CDS NP_312342.1 15833569 915824 4324226..4324495 1 NC_002695.1 similar to YHHL_ECOLI gi|1789876 (conserved in Escherichia coli K-12); hypothetical protein 4324495 915824 ECs4315 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312342.1 4324226 D 386585 CDS NP_312343.1 15833570 915827 complement(4324498..4324857) 1 NC_002695.1 similar to YHHM_ECOLI gi|1789877 (conserved in Escherichia coli K-12); receptor 4324857 915827 ECs4316 Escherichia coli O157:H7 str. Sakai receptor NP_312343.1 4324498 R 386585 CDS NP_312344.1 15833571 915828 4324998..4325624 1 NC_002695.1 similar to YHHN_ECOLI gi|1789878 (conserved in Escherichia coli K-12); hypothetical protein 4325624 915828 ECs4317 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312344.1 4324998 D 386585 CDS NP_312345.1 15833572 915826 4325698..4327896 1 NC_002695.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4327896 zntA 915826 zntA Escherichia coli O157:H7 str. Sakai zinc/cadmium/mercury/lead-transporting ATPase NP_312345.1 4325698 D 386585 CDS NP_312346.1 15833573 915823 complement(4327998..4328243) 1 NC_002695.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 4328243 915823 ECs4319 Escherichia coli O157:H7 str. Sakai sulfur transfer protein SirA NP_312346.1 4327998 R 386585 CDS NP_312347.1 15833574 915822 4328464..4329129 1 NC_002695.1 similar to YHHQ_ECOLI gi|1789882 (conserved in Escherichia coli K-12); hypothetical protein 4329129 915822 ECs4320 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312347.1 4328464 D 386585 CDS NP_312348.3 162139724 915821 4329202..4329759 1 NC_002695.1 similar to B3472_ECOLI gi|1789883 (conserved in Escherichia coli K-12); hypothetical protein 4329759 915821 ECs4321 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312348.3 4329202 D 386585 CDS NP_312349.2 162139749 915820 complement(4329763..4330980) 1 NC_002695.1 similar to YHHS_ECOLI gi|1789884 (conserved in Escherichia coli K-12); major facilitator superfamily transporter 4330980 915820 ECs4322 Escherichia coli O157:H7 str. Sakai major facilitator superfamily transporter NP_312349.2 4329763 R 386585 CDS NP_312350.2 38704170 915819 4331112..4332161 1 NC_002695.1 similar to YHHT_ECOLI gi|1789885 (conserved in Escherichia coli K-12); hypothetical protein 4332161 915819 ECs4323 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312350.2 4331112 D 386585 CDS NP_312351.1 15833578 915818 4332553..4332930 1 NC_002695.1 lipoprotein 4332930 915818 ECs4324 Escherichia coli O157:H7 str. Sakai lipoprotein NP_312351.1 4332553 D 386585 CDS NP_312352.1 15833579 916260 4332999..4334060 1 NC_002695.1 similar to O-methyltransferases e.g. acetylserotonin N-methyltransferase (EC 2.1.1.4) - chicken gi|2498445|sp|Q92056|HIOM_CHICK; O-methyltransferase 4334060 916260 ECs4325 Escherichia coli O157:H7 str. Sakai O-methyltransferase NP_312352.1 4332999 D 386585 CDS NP_312353.1 15833580 916231 4334239..4334823 1 NC_002695.1 hypothetical protein 4334823 916231 ECs4326 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312353.1 4334239 D 386585 CDS NP_312354.1 15833581 916267 4334832..4335641 1 NC_002695.1 similar to acyltransferases e.g. [Neisseria meningitidis MC58] gi|7226953|gb|AAF42046.1|; acyltransferase 4335641 916267 ECs4327 Escherichia coli O157:H7 str. Sakai acyltransferase NP_312354.1 4334832 D 386585 CDS NP_312355.1 15833582 916270 4335616..4335873 1 NC_002695.1 similar to acyl carrier proteins e.g. [Neisseria meningitidis MC58] gi|7226952|gb|AAF42045.1|; acyl carrier protein 4335873 916270 ECs4328 Escherichia coli O157:H7 str. Sakai acyl carrier protein NP_312355.1 4335616 D 386585 CDS NP_312356.1 15833583 916293 4335885..4336136 1 NC_002695.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 4336136 916293 ECs4329 Escherichia coli O157:H7 str. Sakai acyl carrier protein NP_312356.1 4335885 D 386585 CDS NP_312357.1 15833584 915817 4336141..4336722 1 NC_002695.1 similar to integral membrane protein [Neisseria meningitidis] gi|7380586|emb|CAB85174.1; hypothetical protein 4336722 915817 ECs4330 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312357.1 4336141 D 386585 CDS NP_312358.1 15833585 915815 4336719..4338080 1 NC_002695.1 similar to peptide synthase [Xylella fastidiosa] gi|9105980|gb|AAF83848.1|AE003941_2, p-coumaryl-CoA ligase [Rhodobacter sphaeroides] gi|2764724|emb|CAA05380.1; surfactin synthetase 4338080 915815 ECs4331 Escherichia coli O157:H7 str. Sakai surfactin synthetase NP_312358.1 4336719 D 386585 CDS NP_312359.1 15833586 915814 4338067..4338420 1 NC_002695.1 similar to (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratases e.g. [Salmonella typhimurium] gi|140182|sp|P21773|FABZ_SALTY; (3R)-hydroxymyristoyl-ACP dehydratase 4338420 915814 ECs4332 Escherichia coli O157:H7 str. Sakai (3R)-hydroxymyristoyl-ACP dehydratase NP_312359.1 4338067 D 386585 CDS NP_312360.1 15833587 915808 4338411..4340087 1 NC_002695.1 similar to dolichyl-phosphate mannose synthase related protein Pyrococcus abyssi strain Orsay A75176; hypothetical protein 4340087 915808 ECs4333 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312360.1 4338411 D 386585 CDS NP_312361.1 15833588 916364 4340091..4340513 1 NC_002695.1 similar to hypothetical proteins e.g.[Deinococcus radiodurans] gi|7471367|pir||B75463; hypothetical protein 4340513 916364 ECs4334 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312361.1 4340091 D 386585 CDS NP_312362.1 15833589 915809 4340510..4341115 1 NC_002695.1 hypothetical protein 4341115 915809 ECs4335 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312362.1 4340510 D 386585 CDS NP_312363.1 15833590 915813 4341153..4343402 1 NC_002695.1 similar to membrane protein [Xylella fastidiosa] gi|9105671|gb|AAF83587.1|AE003918_9; hypothetical protein 4343402 915813 ECs4336 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312363.1 4341153 D 386585 CDS NP_312364.1 15833591 915812 4343399..4343983 1 NC_002695.1 lipoprotein 4343983 915812 ECs4337 Escherichia coli O157:H7 str. Sakai lipoprotein NP_312364.1 4343399 D 386585 CDS NP_312365.1 15833592 915811 4343985..4345154 1 NC_002695.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4345154 915811 ECs4338 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP synthase NP_312365.1 4343985 D 386585 CDS NP_312366.1 15833593 915810 4345151..4345615 1 NC_002695.1 similar tobeta-hydroxydecanoyl-ACP dehydrase [Pseudomonas aeruginosa] gi|2384563|gb|AAC45619.1|, beta-hydroxydecanoyl-ACP dehydrase,; similar to hypothetical protein [Neisseria meningitidis MC58] gi|7226956|gb|AAF42049.1; beta-hydroxydecanoyl-ACP dehydrase 4345615 915810 ECs4339 Escherichia coli O157:H7 str. Sakai beta-hydroxydecanoyl-ACP dehydrase NP_312366.1 4345151 D 386585 CDS NP_312367.1 15833594 915807 4345615..4346346 1 NC_002695.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4346346 fabG 915807 fabG Escherichia coli O157:H7 str. Sakai 3-ketoacyl-ACP reductase NP_312367.1 4345615 D 386585 CDS NP_312368.1 15833595 915806 4346343..4347572 1 NC_002695.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4347572 915806 ECs4341 Escherichia coli O157:H7 str. Sakai 3-oxoacyl-ACP synthase NP_312368.1 4346343 D 386585 CDS NP_312369.1 15833596 915791 4347574..4348161 1 NC_002695.1 similar to YHHU_ECOLI gi|1789886 (conserved in Escherichia coli K-12); holo-ACP synthase 4348161 915791 ECs4342 Escherichia coli O157:H7 str. Sakai holo-ACP synthase NP_312369.1 4347574 D 386585 CDS NP_312370.1 15833597 915792 4348272..4349846 1 NC_002695.1 similar to NIKA_ECOLI gi|1789887 (conserved in Escherichia coli K-12); periplasmic binding protein for nickel 4349846 915792 ECs4343 Escherichia coli O157:H7 str. Sakai periplasmic binding protein for nickel NP_312370.1 4348272 D 386585 CDS NP_312371.1 15833598 915803 4349846..4350790 1 NC_002695.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4350790 915803 ECs4344 Escherichia coli O157:H7 str. Sakai nickel transporter permease NikB NP_312371.1 4349846 D 386585 CDS NP_312372.1 15833599 915805 4350787..4351620 1 NC_002695.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4351620 nikC 915805 nikC Escherichia coli O157:H7 str. Sakai nickel transporter permease NikC NP_312372.1 4350787 D 386585 CDS NP_312373.1 15833600 915804 4351620..4352384 1 NC_002695.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4352384 nikD 915804 nikD Escherichia coli O157:H7 str. Sakai nickel transporter ATP-binding protein NikD NP_312373.1 4351620 D 386585 CDS NP_312374.1 15833601 915802 4352381..4353187 1 NC_002695.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4353187 nikE 915802 nikE Escherichia coli O157:H7 str. Sakai nickel transporter ATP-binding protein NikE NP_312374.1 4352381 D 386585 CDS NP_312375.1 15833602 915801 4353193..4353594 1 NC_002695.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4353594 915801 ECs4348 Escherichia coli O157:H7 str. Sakai nickel responsive regulator NP_312375.1 4353193 D 386585 CDS NP_312376.2 38704171 915800 4353793..4354539 1 NC_002695.1 similar to transcription regulators e.g. [Escherichia coli] gi|129347|sp|P13669|FARR_ECOLI; GntR family transcriptional regulator 4354539 915800 ECs4349 Escherichia coli O157:H7 str. Sakai GntR family transcriptional regulator NP_312376.2 4353793 D 386585 CDS NP_312377.1 15833604 915799 4354564..4355037 1 NC_002695.1 similar to PTS system enzyme IIA components e.g. [Escherichia coli K-12] gi|2507274|sp|P37187|PTKA_ECOLI, PTS system frucrose-specific enzyme IIBC component; phosphotransferase system enzyme IIA 4355037 915799 ECs4350 Escherichia coli O157:H7 str. Sakai phosphotransferase system enzyme IIA NP_312377.1 4354564 D 386585 CDS NP_312378.1 15833605 915798 4355034..4355315 1 NC_002695.1 similar to PTS system, galactitol-specific IIB component [Escherichia coli K-12] gi|2507273|sp|P37188|PTKB_ECOLI; phosphotransferase system enzyme IIB 4355315 915798 ECs4351 Escherichia coli O157:H7 str. Sakai phosphotransferase system enzyme IIB NP_312378.1 4355034 D 386585 CDS NP_312379.1 15833606 915797 4355392..4356750 1 NC_002695.1 similar to PTS system galactitol-specific enzyme IIC e.g. [Bacillus halodurans] gi|4512376|dbj|BAA75340.1; phosphotransferase system enzyme IIC 4356750 915797 ECs4352 Escherichia coli O157:H7 str. Sakai phosphotransferase system enzyme IIC NP_312379.1 4355392 D 386585 CDS NP_312380.1 15833607 915796 4356743..4358251 1 NC_002695.1 similar to sugar kinases e.g. xylulokinase (EC 2.7.1.17) [Lactobacillus pentosus] gi|139850|sp|P21939|XYLB_LACPE; sugar kinase 4358251 915796 ECs4353 Escherichia coli O157:H7 str. Sakai sugar kinase NP_312380.1 4356743 D 386585 CDS NP_312381.1 15833608 915795 4358241..4358510 1 NC_002695.1 similar to phosphotransferase system HPr enzymes e.g. [Xylella fastidiosa] gi|9106413|gb|AAF84212.1|AE003971_11; phosphotransferase system HPr enzyme 4358510 915795 ECs4354 Escherichia coli O157:H7 str. Sakai phosphotransferase system HPr enzyme NP_312381.1 4358241 D 386585 CDS NP_312382.1 15833609 915793 4358542..4359402 1 NC_002695.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 4359402 gatY 915793 gatY Escherichia coli O157:H7 str. Sakai fructose-1,6-bisphosphate aldolase NP_312382.1 4358542 D 386585 CDS NP_312383.1 15833610 915789 complement(4359452..4359811) 1 NC_002695.1 similar to HicB-related protein [Xylella fastidiosa] gi|9106728|gb|AAF84477.1|AE003992_13, HicB [Haemophilus influenzae] gi|3603326|gb|AAC35810.1; HicB-like protein 4359811 915789 ECs4356 Escherichia coli O157:H7 str. Sakai HicB-like protein NP_312383.1 4359452 R 386585 CDS NP_312384.1 15833611 913929 complement(4359808..4360083) 1 NC_002695.1 similar to HicA [Haemophilus influenzae] gi|3603325|gb|AAC35809.1; HicA-like protein 4360083 913929 ECs4357 Escherichia coli O157:H7 str. Sakai HicA-like protein NP_312384.1 4359808 R 386585 CDS NP_312385.2 38704172 913953 complement(4360156..4361280) 1 NC_002695.1 similar to YHHJ_ECOLI gi|1789897 (conserved in Escherichia coli K-12); transporter 4361280 913953 ECs4358 Escherichia coli O157:H7 str. Sakai transporter NP_312385.2 4360156 R 386585 CDS NP_312386.1 15833613 915790 complement(4361280..4363964) 1 NC_002695.1 similar to YHIH_ECOLI gi|2367231 (conserved in Escherichia coli K-12); ABC transporter ATP-binding protein 4363964 915790 ECs4359 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_312386.1 4361280 R 386585 CDS NP_312387.1 15833614 915786 complement(4364012..4365079) 1 NC_002695.1 similar to YHII_ECOLI gi|1789900 (conserved in Escherichia coli K-12); hypothetical protein 4365079 915786 ECs4360 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312387.1 4364012 R 386585 CDS NP_312388.1 15833615 915788 complement(4365445..4367067) 1 NC_002695.1 similar to YHIJ_ECOLI gi|1789902 (conserved in Escherichia coli K-12); hypothetical protein 4367067 915788 ECs4361 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312388.1 4365445 R 386585 CDS NP_312389.1 15833616 915787 complement(4367329..4368939) 1 NC_002695.1 similar to YHIL_ECOLI gi|2367233, YHIK_ECOLI gi|1789903; hypothetical protein 4368939 915787 ECs4362 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312389.1 4367329 R 386585 CDS NP_312390.1 15833617 915782 4369224..4370375 1 NC_002695.1 similar to YHIM_ECOLI gi|1789905 (conserved in Escherichia coli K-12); hypothetical protein 4370375 915782 ECs4363 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312390.1 4369224 D 386585 CDS NP_312391.1 15833618 914038 complement(4370693..4371895) 1 NC_002695.1 similar to YHIN_ECOLI gi|2367234 (conserved in Escherichia coli K-12); hypothetical protein 4371895 914038 ECs4364 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312391.1 4370693 R 386585 CDS NP_312392.1 15833619 913986 4372127..4373626 1 NC_002695.1 similar to PITB_ECOLI gi|1789360 (conserved in Escherichia coli K-12); low-affinity phosphate transport protein 4373626 913986 ECs4365 Escherichia coli O157:H7 str. Sakai low-affinity phosphate transport protein NP_312392.1 4372127 D 386585 CDS NP_312393.1 15833620 915774 complement(4373697..4374032) 1 NC_002695.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4374032 915774 ECs4366 Escherichia coli O157:H7 str. Sakai universal stress protein UspB NP_312393.1 4373697 R 386585 CDS NP_312394.1 15833621 915784 4374423..4374857 1 NC_002695.1 similar to USPA_ECOLI gi|1789909 (conserved in Escherichia coli K-12); hypothetical protein 4374857 915784 ECs4367 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312394.1 4374423 D 386585 CDS NP_312395.1 15833622 915768 4375174..4376643 1 NC_002695.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4376643 915768 ECs4368 Escherichia coli O157:H7 str. Sakai inner membrane transporter YhiP NP_312395.1 4375174 D 386585 CDS NP_312396.1 15833623 915773 complement(4376692..4377444) 1 NC_002695.1 predicted SAM-dependent methyltransferase; methyltransferase 4377444 915773 ECs4369 Escherichia coli O157:H7 str. Sakai methyltransferase NP_312396.1 4376692 R 386585 CDS NP_312397.1 15833624 914095 complement(4377452..4379494) 1 NC_002695.1 similar to PRLC_ECOLI gi|1789913 (conserved in Escherichia coli K-12); oligopeptidase A 4379494 914095 ECs4370 Escherichia coli O157:H7 str. Sakai oligopeptidase A NP_312397.1 4377452 R 386585 CDS NP_312398.1 15833625 915775 4379697..4380539 1 NC_002695.1 similar to YHIR_ECOLI gi|1789914 (conserved in Escherichia coli K-12); hypothetical protein 4380539 915775 ECs4371 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312398.1 4379697 D 386585 CDS NP_312399.1 15833626 915781 4380611..4381963 1 NC_002695.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4381963 915781 ECs4372 Escherichia coli O157:H7 str. Sakai glutathione reductase NP_312399.1 4380611 D 386585 CDS NP_312400.1 15833627 915778 4382844..4383197 1 NC_002695.1 regulates the expression of of the arsRBC involved in resistance to arsenic; ArsR family transcriptional regulator 4383197 915778 ECs4373 Escherichia coli O157:H7 str. Sakai ArsR family transcriptional regulator NP_312400.1 4382844 D 386585 CDS NP_312401.1 15833628 915771 4383251..4384540 1 NC_002695.1 similar to ARSF_ECOLI gi|1789917 (conserved in Escherichia coli K-12); arsenical pump membrane protein 4384540 915771 ECs4374 Escherichia coli O157:H7 str. Sakai arsenical pump membrane protein NP_312401.1 4383251 D 386585 CDS NP_312402.1 15833629 915766 4384553..4384978 1 NC_002695.1 similar to ARSC_ECOLI gi|1789918 (conserved in Escherichia coli K-12); arsenate reductase 4384978 915766 ECs4375 Escherichia coli O157:H7 str. Sakai arsenate reductase NP_312402.1 4384553 D 386585 CDS NP_312403.1 15833630 915740 4385605..4386720 1 NC_002695.1 similar to YHIS_ECOLI gi|1789920 (conserved in Escherichia coli K-12); hypothetical protein 4386720 915740 ECs4376 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312403.1 4385605 D 386585 CDS NP_312404.2 38704173 915741 4387074..4387640 1 NC_002695.1 outer membrane protein; similar to SLP_ECOLI gi|1789922 (conserved in Escherichia coli K-12); hypothetical protein 4387640 915741 ECs4377 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312404.2 4387074 D 386585 CDS NP_312405.1 15833632 915765 4387796..4388326 1 NC_002695.1 similar to YHIF_ECOLI gi|1789923 (conserved in Escherichia coli K-12); hypothetical protein 4388326 915765 ECs4378 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312405.1 4387796 D 386585 CDS NP_312406.1 15833633 915764 complement(4388387..4389415) 1 NC_002695.1 hypothetical protein 4389415 915764 ECs4379 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312406.1 4388387 R 386585 CDS NP_312407.1 15833634 915763 complement(4389464..4391446) 1 NC_002695.1 similar to ChuA [Escherichia coli O157:H7 EDL933] gi|1763009|gb|AAC44857.1|; heme utilization/transport protein 4391446 915763 ECs4380 Escherichia coli O157:H7 str. Sakai heme utilization/transport protein NP_312407.1 4389464 R 386585 CDS NP_312408.1 15833635 915762 complement(4391722..4391928) 1 NC_002695.1 hypothetical protein 4391928 915762 ECs4381 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312408.1 4391722 R 386585 CDS NP_312409.1 15833636 915761 4392129..4393043 1 NC_002695.1 similar to hypothetical protein ShuT [Shigella dysenteriae haem transport locus] gi|2967538|gb|AAC27815.1, hemin-binding proteins e.g. [Yersinia pestis] gi|6226635|; hemin binding protein 4393043 915761 ECs4382 Escherichia coli O157:H7 str. Sakai hemin binding protein NP_312409.1 4392129 D 386585 CDS NP_312410.1 15833637 915760 4393063..4394400 1 NC_002695.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4394400 915760 ECs4383 Escherichia coli O157:H7 str. Sakai coproporphyrinogen III oxidase NP_312410.1 4393063 D 386585 CDS NP_312411.1 15833638 915759 4394413..4394907 1 NC_002695.1 similar to hypothetical protein ShuX [Shigella dysenteriae haem transport locus] gi|2967537|gb|AAC27814.1|, hypothetical protein X [Yersinia pestis] gi|7467368|pir||T12066; ShuX-like protein 4394907 915759 ECs4384 Escherichia coli O157:H7 str. Sakai ShuX-like protein NP_312411.1 4394413 D 386585 CDS NP_312412.1 15833639 915758 4394907..4395530 1 NC_002695.1 similar to hypothetical protein ShuY [Shigella dysenteriae haem transport locus] gi|2967536|gb|AAC27813.1|, hypothetical protein Y [Yersinia pestis] gi|7467369|pir||T12067; ShuY-like protein 4395530 915758 ECs4385 Escherichia coli O157:H7 str. Sakai ShuY-like protein NP_312412.1 4394907 D 386585 CDS NP_312413.1 15833640 915757 4395615..4396571 1 NC_002695.1 similar to hypothetical protein ShuU [Shigella dysenteriae haem transport locus] gi|2967535|gb|AAC27812.1|, hemin permeases e.g. HmuU [Yersinia pestis] gi|6226636|sp|Q56992|HMUU_YER; hemin permease 4396571 915757 ECs4386 Escherichia coli O157:H7 str. Sakai hemin permease NP_312413.1 4395615 D 386585 CDS NP_312414.1 15833641 915756 4396568..4397338 1 NC_002695.1 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding protein 4397338 hmuV 915756 hmuV Escherichia coli O157:H7 str. Sakai hemin importer ATP-binding protein NP_312414.1 4396568 D 386585 CDS NP_312415.1 15833642 915755 complement(4397390..4398037) 1 NC_002695.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase 4398037 915755 ECs4388 Escherichia coli O157:H7 str. Sakai Mg(2+) transport ATPase NP_312415.1 4397390 R 386585 CDS NP_312416.1 15833643 915754 complement(4398101..4398439) 1 NC_002695.1 similar to HDEB_ECOLI gi|1789925 (conserved in Escherichia coli K-12); acid-resistance protein 4398439 hdeB 915754 hdeB Escherichia coli O157:H7 str. Sakai acid-resistance protein NP_312416.1 4398101 R 386585 CDS NP_312417.1 15833644 915753 complement(4398543..4398875) 1 NC_002695.1 inactive form; acid-resistance protein 4398875 915753 ECs4390 Escherichia coli O157:H7 str. Sakai acid-resistance protein NP_312417.1 4398543 R 386585 CDS NP_312418.1 15833645 915752 4399130..4399702 1 NC_002695.1 similar to HDED_ECOLI gi|1789927 (conserved in Escherichia coli K-12); acid-resistance membrane protein 4399702 915752 ECs4391 Escherichia coli O157:H7 str. Sakai acid-resistance membrane protein NP_312418.1 4399130 D 386585 CDS NP_312419.1 15833646 915751 4400501..4401028 1 NC_002695.1 similar to YHIE_ECOLI gi|1789928 (conserved in Escherichia coli K-12); hypothetical protein 4401028 915751 ECs4392 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312419.1 4400501 D 386585 CDS NP_944565.1 38704174 2693781 complement(4401029..4401307) 1 NC_002695.1 hypothetical protein 4401307 2693781 ECs5533 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944565.1 4401029 R 386585 CDS NP_312420.1 15833647 915750 4401367..4402524 1 NC_002695.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4402524 915750 ECs4393 Escherichia coli O157:H7 str. Sakai multidrug efflux system protein MdtE NP_312420.1 4401367 D 386585 CDS NP_312421.1 15833648 915749 4402549..4405662 1 NC_002695.1 similar to YHIV_ECOLI gi|1789930 (conserved in Escherichia coli K-12); transport system permease 4405662 915749 ECs4394 Escherichia coli O157:H7 str. Sakai transport system permease NP_312421.1 4402549 D 386585 CDS NP_312422.1 15833649 915748 complement(4406025..4406753) 1 NC_002695.1 similar to YHIW_ECOLI gi|1789932 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 4406753 915748 ECs4395 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_312422.1 4406025 R 386585 CDS NP_312423.1 15833650 915747 complement(4407121..4407945) 1 NC_002695.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4407945 915747 ECs4396 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator GadX NP_312423.1 4407121 R 386585 CDS NP_312424.1 15833651 915746 complement(4408316..4409716) 1 NC_002695.1 similar to GADB_ECOLI gi|1787769 (conserved in Escherichia coli K-12); glutamate decarboxylase 4409716 915746 ECs4397 Escherichia coli O157:H7 str. Sakai glutamate decarboxylase NP_312424.1 4408316 R 386585 CDS NP_312425.1 15833652 915744 complement(4409927..4411324) 1 NC_002695.1 similar to YHJA_ECOLI gi|1789935 (conserved in Escherichia coli K-12); cytochrome C peroxidase 4411324 915744 ECs4398 Escherichia coli O157:H7 str. Sakai cytochrome C peroxidase NP_312425.1 4409927 R 386585 CDS NP_312426.1 15833653 915743 4411729..4413378 1 NC_002695.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4413378 treF 915743 treF Escherichia coli O157:H7 str. Sakai trehalase NP_312426.1 4411729 D 386585 CDS NP_312427.1 15833654 915742 complement(4413429..4414031) 1 NC_002695.1 similar to YHJB_ECOLI gi|1789937 (conserved in Escherichia coli K-12); regulator 4414031 915742 ECs4400 Escherichia coli O157:H7 str. Sakai regulator NP_312427.1 4413429 R 386585 CDS NP_312428.1 15833655 915735 4414479..4415450 1 NC_002695.1 similar to YHJC_ECOLI gi|1789938 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 4415450 915735 ECs4401 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_312428.1 4414479 D 386585 CDS NP_312429.1 15833656 915736 4415499..4416512 1 NC_002695.1 similar to YHJD_ECOLI gi|1789939 (conserved in Escherichia coli K-12); hypothetical protein 4416512 915736 ECs4402 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312429.1 4415499 D 386585 CDS NP_312430.1 15833657 915737 4416924..4418246 1 NC_002695.1 similar to YHJE_ECOLI gi|1789941 (conserved in Escherichia coli K-12); transporter 4418246 915737 ECs4403 Escherichia coli O157:H7 str. Sakai transporter NP_312430.1 4416924 D 386585 CDS NP_312431.1 15833658 915738 complement(4418428..4420503) 1 NC_002695.1 similar to YHJG_ECOLI gi|2367236 (conserved in Escherichia coli K-12); hypothetical protein 4420503 915738 ECs4404 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312431.1 4418428 R 386585 CDS NP_312432.1 15833659 915731 complement(4420558..4421328) 1 NC_002695.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 4421328 915731 ECs4405 Escherichia coli O157:H7 str. Sakai EAL domain-containing protein NP_312432.1 4420558 R 386585 CDS NP_312433.1 15833660 915730 4421338..4422486 1 NC_002695.1 similar to KDGK_ECOLI gi|1789945 (conserved in Escherichia coli K-12); 2-dehydro-3-deoxygluconokinase 4422486 915730 ECs4406 Escherichia coli O157:H7 str. Sakai 2-dehydro-3-deoxygluconokinase NP_312433.1 4421338 D 386585 CDS NP_312434.1 15833661 915732 complement(4422582..4424078) 1 NC_002695.1 similar to YHJJ_ECOLI gi|1789946 (conserved in Escherichia coli K-12); hypothetical protein 4424078 915732 ECs4407 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312434.1 4422582 R 386585 CDS NP_312435.1 15833662 915733 complement(4424299..4425585) 1 NC_002695.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4425585 915733 ECs4408 Escherichia coli O157:H7 str. Sakai C4-dicarboxylate transporter DctA NP_312435.1 4424299 R 386585 CDS NP_312436.1 15833663 915734 complement(4425768..4427723) 1 NC_002695.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 4427723 915734 ECs4409 Escherichia coli O157:H7 str. Sakai phosphodiesterase NP_312436.1 4425768 R 386585 CDS NP_312437.1 15833664 915729 complement(4427838..4430846) 1 NC_002695.1 similar to YHJL_ECOLI gi|2367239 (conserved in Escherichia coli K-12); oxidoreductase subunit 4430846 915729 ECs4410 Escherichia coli O157:H7 str. Sakai oxidoreductase subunit NP_312437.1 4427838 R 386585 CDS NP_312438.1 15833665 915724 complement(4431283..4432389) 1 NC_002695.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4432389 915724 ECs4411 Escherichia coli O157:H7 str. Sakai endo-1,4-D-glucanase NP_312438.1 4431283 R 386585 CDS NP_312439.1 15833666 915722 complement(4432396..4434753) 1 NC_002695.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4434753 915722 ECs4412 Escherichia coli O157:H7 str. Sakai cellulose synthase regulator protein NP_312439.1 4432396 R 386585 CDS NP_312440.2 38704176 915726 complement(4434764..4437382) 1 NC_002695.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 4437382 bcsA 915726 bcsA Escherichia coli O157:H7 str. Sakai cellulose synthase catalytic subunit NP_312440.2 4434764 R 386585 CDS NP_312441.1 15833668 915727 complement(4437379..4437915) 1 NC_002695.1 similar to YHJQ_ECOLI gi|1789955; hypothetical protein 4437915 915727 ECs4414 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312441.1 4437379 R 386585 CDS NP_312442.1 15833669 915723 complement(4438143..4438331) 1 NC_002695.1 similar to YHJR_ECOLI gi|1789956 (conserved in Escherichia coli K-12); hypothetical protein 4438331 915723 ECs4415 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312442.1 4438143 R 386585 CDS NP_312443.1 15833670 915725 4438604..4440175 1 NC_002695.1 similar to YHJS_ECOLI gi|1789958 (conserved in Escherichia coli K-12); protease 4440175 915725 ECs4416 Escherichia coli O157:H7 str. Sakai protease NP_312443.1 4438604 D 386585 CDS NP_312444.1 15833671 915718 4440175..4440363 1 NC_002695.1 similar to YHJT_ECOLI gi|1789959 (conserved in Escherichia coli K-12); hypothetical protein 4440363 915718 ECs4417 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312444.1 4440175 D 386585 CDS NP_312445.1 15833672 915719 4440360..4442039 1 NC_002695.1 similar to YHJU_ECOLI gi|1789960 (conserved in Escherichia coli K-12); hypothetical protein 4442039 915719 ECs4418 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312445.1 4440360 D 386585 CDS NP_312446.1 15833673 915720 4442709..4443980 1 NC_002695.1 similar to YHJV_ECOLI gi|1789961 (conserved in Escherichia coli K-12); transporter protein 4443980 915720 ECs4419 Escherichia coli O157:H7 str. Sakai transporter protein NP_312446.1 4442709 D 386585 CDS NP_312447.1 15833674 915721 complement(4444010..4445014) 1 NC_002695.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; peptide ABC transporter ATP-binding protein 4445014 dppF 915721 dppF Escherichia coli O157:H7 str. Sakai peptide ABC transporter ATP-binding protein NP_312447.1 4444010 R 386585 CDS NP_312448.1 15833675 915714 complement(4445011..4445994) 1 NC_002695.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; peptide ABC transporter ATP-binding protein 4445994 dppD 915714 dppD Escherichia coli O157:H7 str. Sakai peptide ABC transporter ATP-binding protein NP_312448.1 4445011 R 386585 CDS NP_312449.1 15833676 915715 complement(4446005..4446907) 1 NC_002695.1 similar to DPPC_ECOLI gi|1789964 (conserved in Escherichia coli K-12); peptide ABC transporter 4446907 915715 ECs4422 Escherichia coli O157:H7 str. Sakai peptide ABC transporter NP_312449.1 4446005 R 386585 CDS NP_312450.1 15833677 915716 complement(4446917..4447936) 1 NC_002695.1 transports peptides consisting of two or three amino acids; peptide ABC transporter permease 4447936 915716 ECs4423 Escherichia coli O157:H7 str. Sakai peptide ABC transporter permease NP_312450.1 4446917 R 386585 CDS NP_312451.1 15833678 915710 complement(4448087..4449694) 1 NC_002695.1 similar to DPPA_ECOLI gi|1789966 (conserved in Escherichia coli K-12); peptide ABC transporter 4449694 915710 ECs4424 Escherichia coli O157:H7 str. Sakai peptide ABC transporter NP_312451.1 4448087 R 386585 CDS NP_312452.2 38704177 915712 complement(4450607..4452298) 1 NC_002695.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4452298 915712 ECs4425 Escherichia coli O157:H7 str. Sakai phosphoethanolamine transferase NP_312452.2 4450607 R 386585 CDS NP_312453.1 15833680 915704 complement(4452553..4453083) 1 NC_002695.1 similar to fimbrial proteins e.g. long polar fimbrial minor protein precursor [Salmonella typhimurium] gi|1170819|sp|P43664|LPFE_SALTY; fimbrial protein 4453083 915704 ECs4426 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_312453.1 4452553 R 386585 CDS NP_312454.1 15833681 915705 complement(4453088..4454143) 1 NC_002695.1 similar to fimbrial proteins e.g. long polar fimbrial protein LpfD [Salmonella typhimurium] gi|1170818|sp|P43663|LPFD_SALTY; fimbrial protein 4454143 915705 ECs4427 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_312454.1 4453088 R 386585 CDS NP_312457.2 38704178 915707 complement(4456760..4457458) 1 NC_002695.1 probable fimbrial chaperone protein, similar to chaperones e.g. LpfB [Salmonella typhimurium] gi|1170816|sp|P43661|LPFB_SALTY; fimbrial chaperone protein 4457458 915707 ECs4430 Escherichia coli O157:H7 str. Sakai fimbrial chaperone protein NP_312457.2 4456760 R 386585 CDS NP_312458.1 15833685 915703 complement(4457511..4458047) 1 NC_002695.1 similar to long polar fimbria protein A precursor, LpfA, of S. typhimurium, gi|1170815|sp|P43660|LPFA_SALTY; fimbrial major protein 4458047 915703 ECs4431 Escherichia coli O157:H7 str. Sakai fimbrial major protein NP_312458.1 4457511 R 386585 CDS NP_312459.1 15833686 914251 complement(4458379..4459581) 1 NC_002695.1 similar to YHJX_ECOLI gi|1789969 (conserved in Escherichia coli K-12); resistance protein 4459581 914251 ECs4432 Escherichia coli O157:H7 str. Sakai resistance protein NP_312459.1 4458379 R 386585 CDS NP_312460.2 38704179 915700 complement(4459810..4460508) 1 NC_002695.1 similar to YHJY_ECOLI gi|1789970 (conserved in Escherichia coli K-12); lipase 4460508 915700 ECs4433 Escherichia coli O157:H7 str. Sakai lipase NP_312460.2 4459810 R 386585 CDS NP_312461.1 15833688 915701 4460666..4461229 1 NC_002695.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4461229 915701 ECs4434 Escherichia coli O157:H7 str. Sakai 3-methyladenine DNA glycosylase NP_312461.1 4460666 D 386585 CDS NP_312462.1 15833689 915702 4461226..4461666 1 NC_002695.1 similar to YIAC_ECOLI gi|1789972 (conserved in Escherichia coli K-12); hypothetical protein 4461666 915702 ECs4435 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312462.1 4461226 D 386585 CDS NP_312463.1 15833690 915696 complement(4461635..4463854) 1 NC_002695.1 similar to BISC_ECOLI gi|1789973 (conserved in Escherichia coli K-12); biotin sulfoxide reductase 4463854 915696 ECs4436 Escherichia coli O157:H7 str. Sakai biotin sulfoxide reductase NP_312463.1 4461635 R 386585 CDS NP_312464.1 15833691 915683 4464121..4464780 1 NC_002695.1 similar to YIAD_ECOLI gi|1789974 (conserved in Escherichia coli K-12); outer membrane lipoprotein 4464780 915683 ECs4437 Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein NP_312464.1 4464121 D 386585 CDS NP_312465.2 162139748 915671 4464884..4465858 1 NC_002695.1 Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 4465858 915671 ECs4438 Escherichia coli O157:H7 str. Sakai 2-hydroxyacid dehydrogenase NP_312465.2 4464884 D 386585 CDS NP_312466.1 15833693 915662 complement(4465908..4466738) 1 NC_002695.1 similar to YIAF_ECOLI gi|1789976 (conserved in Escherichia coli K-12); hypothetical protein 4466738 915662 ECs4439 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312466.1 4465908 R 386585 CDS NP_312467.1 15833694 915652 4467052..4467342 1 NC_002695.1 similar to YIAG_ECOLI gi|1789978 (conserved in Escherichia coli K-12); transcriptional regulator 4467342 915652 ECs4440 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_312467.1 4467052 D 386585 CDS NP_312468.1 15833695 915643 4467623..4467835 1 NC_002695.1 similar to CSPA_ECOLI gi|1789979 (conserved in Escherichia coli K-12); major cold shock protein 4467835 915643 ECs4441 Escherichia coli O157:H7 str. Sakai major cold shock protein NP_312468.1 4467623 D 386585 CDS NP_312469.1 15833696 915631 complement(4468498..4470567) 1 NC_002695.1 glycine--tRNA ligase subunit beta; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4470567 glyS 915631 glyS Escherichia coli O157:H7 str. Sakai glycyl-tRNA synthetase subunit beta NP_312469.1 4468498 R 386585 CDS NP_312470.1 15833697 915622 complement(4470577..4471488) 1 NC_002695.1 glycine--tRNA ligase subunit alpha; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4471488 glyQ 915622 glyQ Escherichia coli O157:H7 str. Sakai glycyl-tRNA synthetase subunit alpha NP_312470.1 4470577 R 386585 CDS NP_944567.1 38704180 2693783 complement(4471583..4471882) 1 NC_002695.1 hypothetical protein 4471882 2693783 ECs5536 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944567.1 4471583 R 386585 CDS NP_312471.1 15833698 915620 4472057..4473052 1 NC_002695.1 similar to YIAH_ECOLI gi|1789984 (conserved in Escherichia coli K-12); hypothetical protein 4473052 915620 ECs4444 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312471.1 4472057 D 386585 CDS NP_312472.2 38704181 915619 complement(4473094..4473531) 1 NC_002695.1 similar to YIAA_ECOLI gi|1789985 (conserved in Escherichia coli K-12); hypothetical protein 4473531 915619 ECs4445 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312472.2 4473094 R 386585 CDS NP_312473.1 15833700 915617 complement(4473577..4473930) 1 NC_002695.1 similar to YIAB_ECOLI gi|1789986 (conserved in Escherichia coli K-12); hypothetical protein 4473930 915617 ECs4446 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312473.1 4473577 R 386585 CDS NP_312474.1 15833701 915616 complement(4474087..4475541) 1 NC_002695.1 similar to XYLB_ECOLI gi|1789987 (conserved in Escherichia coli K-12); xylulokinase 4475541 915616 ECs4447 Escherichia coli O157:H7 str. Sakai xylulokinase NP_312474.1 4474087 R 386585 CDS NP_312475.1 15833702 915615 complement(4475613..4476935) 1 NC_002695.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 4476935 915615 ECs4448 Escherichia coli O157:H7 str. Sakai xylose isomerase NP_312475.1 4475613 R 386585 CDS NP_312476.1 15833703 915614 4477301..4478293 1 NC_002695.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4478293 xylF 915614 xylF Escherichia coli O157:H7 str. Sakai D-xylose transporter subunit XylF NP_312476.1 4477301 D 386585 CDS NP_312477.1 15833704 915612 4478371..4479912 1 NC_002695.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding protein 4479912 915612 ECs4450 Escherichia coli O157:H7 str. Sakai xylose transporter ATP-binding protein NP_312477.1 4478371 D 386585 CDS NP_312478.1 15833705 915611 4479890..4481071 1 NC_002695.1 similar to XYLH_ECOLI gi|1789992 (conserved in Escherichia coli K-12); membrane component of xylose transport system 4481071 915611 ECs4451 Escherichia coli O157:H7 str. Sakai membrane component of xylose transport system NP_312478.1 4479890 D 386585 CDS NP_312479.1 15833706 915610 4481149..4482327 1 NC_002695.1 similar to XYLR_ECOLI gi|1789993 (conserved in Escherichia coli K-12); regulator of xyl operon 4482327 915610 ECs4452 Escherichia coli O157:H7 str. Sakai regulator of xyl operon NP_312479.1 4481149 D 386585 CDS NP_312480.1 15833707 915609 complement(4482435..4483259) 1 NC_002695.1 similar to BAX_ECOLI gi|1789994 (conserved in Escherichia coli K-12); hypothetical protein 4483259 915609 ECs4453 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312480.1 4482435 R 386585 CDS NP_312481.1 15833708 915608 4483579..4485609 1 NC_002695.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4485609 malS 915608 malS Escherichia coli O157:H7 str. Sakai periplasmic alpha-amylase NP_312481.1 4483579 D 386585 CDS NP_312482.1 15833709 915606 4485787..4487040 1 NC_002695.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4487040 avtA 915606 avtA Escherichia coli O157:H7 str. Sakai valine--pyruvate transaminase NP_312482.1 4485787 D 386585 CDS NP_312483.1 15833710 915605 complement(4487192..4487665) 1 NC_002695.1 similar to YIAI_ECOLI YIAI_ECOLI gi|2367245 (conserved in Escherichia coli K-12); hypothetical protein 4487665 915605 ECs4456 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312483.1 4487192 R 386585 CDS NP_312484.1 15833711 915603 complement(4487909..4488724) 1 NC_002695.1 similar to hypothetical transcriptional regulator YisR [Bacillus subtilis] gi|3123306|sp|P40331; transcriptional regulator 4488724 915603 ECs4457 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_312484.1 4487909 R 386585 CDS NP_312485.1 15833712 915602 4488950..4490350 1 NC_002695.1 similar to hypothetical proteins [Salmonella typhimurium] gi|7442781|pir||C65167, transport proteins ( symporters) e.g. YicJ [Escherichia coli (K-12)] gi|2851421|sp|P31435; permease 4490350 915602 ECs4458 Escherichia coli O157:H7 str. Sakai permease NP_312485.1 4488950 D 386585 CDS NP_312486.1 15833713 915600 4490361..4492331 1 NC_002695.1 similar to hypothetical protein [Thermotoga maritima] gi|7452109|pir||F72395; hypothetical protein 4492331 915600 ECs4459 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312486.1 4490361 D 386585 CDS NP_312487.1 15833714 915598 complement(4492461..4493201) 1 NC_002695.1 similar to YIAT_ECOLI gi|1790010 (conserved in Escherichia coli K-12); outer membrane protein 4493201 915598 ECs4460 Escherichia coli O157:H7 str. Sakai outer membrane protein NP_312487.1 4492461 R 386585 CDS NP_312488.1 15833715 916039 4493325..4494299 1 NC_002695.1 similar to YIAU_ECOLI gi|1790011 (conserved in Escherichia coli K-12); LysR family transcriptional regulator 4494299 916039 ECs4461 Escherichia coli O157:H7 str. Sakai LysR family transcriptional regulator NP_312488.1 4493325 D 386585 CDS NP_312489.1 15833716 916069 complement(4494296..4495432) 1 NC_002695.1 similar to YIAV_ECOLI gi|1790012 (conserved in Escherichia coli K-12); hypothetical protein 4495432 916069 ECs4462 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312489.1 4494296 R 386585 CDS NP_312490.1 15833717 916071 complement(4495438..4495761) 1 NC_002695.1 similar to YIAW_ECOLI gi|1790013 (conserved in Escherichia coli K-12); hypothetical protein 4495761 916071 ECs4463 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312490.1 4495438 R 386585 CDS NP_312491.2 38704182 915596 complement(4496306..4497844) 1 NC_002695.1 similar to ALDB_ECOLI gi|1790014 (conserved in Escherichia coli K-12); aldehyde dehydrogenase 4497844 915596 ECs4464 Escherichia coli O157:H7 str. Sakai aldehyde dehydrogenase NP_312491.2 4496306 R 386585 CDS NP_312492.1 15833719 915595 complement(4497952..4499247) 1 NC_002695.1 similar to hypothetical protein [Neisseria meningitidis MC58] gi|7227012|gb|AAF42100.1; hypothetical protein 4499247 915595 ECs4465 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312492.1 4497952 R 386585 CDS NP_312493.1 15833720 915594 complement(4499377..4500528) 1 NC_002695.1 similar to YIAY_ECOLI gi|1790015 (conserved in Escherichia coli K-12); alcohol dehydrogenase 4500528 915594 ECs4466 Escherichia coli O157:H7 str. Sakai alcohol dehydrogenase NP_312493.1 4499377 R 386585 CDS NP_312494.1 15833721 915593 complement(4500717..4502561) 1 NC_002695.1 similar to SELB_ECOLI gi|2367247 (conserved in Escherichia coli K-12); selenocysteinyl-tRNA-specific translation factor 4502561 915593 ECs4467 Escherichia coli O157:H7 str. Sakai selenocysteinyl-tRNA-specific translation factor NP_312494.1 4500717 R 386585 CDS NP_312495.1 15833722 915592 complement(4502558..4503949) 1 NC_002695.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4503949 915592 ECs4468 Escherichia coli O157:H7 str. Sakai selenocysteine synthase NP_312495.1 4502558 R 386585 CDS NP_312496.1 15833723 915591 complement(4504047..4504655) 1 NC_002695.1 similar to YIBF_ECOLI gi|1790018 (conserved in Escherichia coli K-12); glutathione S-transferase 4504655 915591 ECs4469 Escherichia coli O157:H7 str. Sakai glutathione S-transferase NP_312496.1 4504047 R 386585 CDS NP_312497.1 15833724 915590 4504884..4509113 1 NC_002695.1 similar to Rhs core RHSA_ECOLI gi|1790020 (conserved in Escherichia coli K-12); rhsA core protein with extension 4509113 915590 ECs4470 Escherichia coli O157:H7 str. Sakai rhsA core protein with extension NP_312497.1 4504884 D 386585 CDS NP_312498.1 15833725 915589 4509125..4509586 1 NC_002695.1 similar to YIBG_ECOLI gi|1790023 (conserved in Escherichia coli K-12); hypothetical protein 4509586 915589 ECs4471 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312498.1 4509125 D 386585 CDS NP_312499.1 15833726 915588 4510293..4510628 1 NC_002695.1 hypothetical protein 4510628 915588 ECs4472 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312499.1 4510293 D 386585 CDS NP_312500.1 15833727 915586 complement(4511190..4512326) 1 NC_002695.1 similar to YIBH_ECOLI gi|1790024; hypothetical protein 4512326 915586 ECs4473 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312500.1 4511190 R 386585 CDS NP_312501.1 15833728 915584 complement(4512329..4512691) 1 NC_002695.1 similar to YIBI_ECOLI gi|1790025 (conserved in Escherichia coli K-12); hypothetical protein 4512691 915584 ECs4474 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312501.1 4512329 R 386585 CDS NP_312502.1 15833729 915583 4513228..4515141 1 NC_002695.1 similar to MTLA_ECOLI gi|1790027 (conserved in Escherichia coli K-12); mannitol-specific PTS system enzyme IIABC components 4515141 915583 ECs4475 Escherichia coli O157:H7 str. Sakai mannitol-specific PTS system enzyme IIABC components NP_312502.1 4513228 D 386585 CDS NP_312503.1 15833730 915582 4515236..4516384 1 NC_002695.1 similar to MTLD_ECOLI gi|1790028 (conserved in Escherichia coli K-12); mannitol-1-phosphate 5-dehydrogenase 4516384 915582 ECs4476 Escherichia coli O157:H7 str. Sakai mannitol-1-phosphate 5-dehydrogenase NP_312503.1 4515236 D 386585 CDS NP_312504.1 15833731 915581 4516384..4516971 1 NC_002695.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4516971 mtlR 915581 mtlR Escherichia coli O157:H7 str. Sakai mannitol repressor protein NP_312504.1 4516384 D 386585 CDS NP_312505.1 15833732 915580 4517477..4517839 1 NC_002695.1 similar to YIBL_ECOLI gi|1790030 (conserved in Escherichia coli K-12); hypothetical protein 4517839 915580 ECs4478 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312505.1 4517477 D 386585 CDS NP_312506.1 15833733 915579 4518484..4519065 1 NC_002695.1 hypothetical protein 4519065 915579 ECs4479 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312506.1 4518484 D 386585 CDS NP_312507.1 15833734 915578 4519109..4523875 1 NC_002695.1 similar to surface proteins, e.g.[Xylella fastidiosa] gi|9106565|gb|AAF84338.1|AE003982_11; hypothetical protein 4523875 915578 ECs4480 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312507.1 4519109 D 386585 CDS NP_312508.1 15833735 915577 4524243..4525898 1 NC_002695.1 similar to LLDP_ECOLI gi|1790031 (conserved in Escherichia coli K-12); L-lactate permease 4525898 915577 ECs4481 Escherichia coli O157:H7 str. Sakai L-lactate permease NP_312508.1 4524243 D 386585 CDS NP_312509.1 15833736 915576 4525898..4526674 1 NC_002695.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4526674 915576 ECs4482 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor LldR NP_312509.1 4525898 D 386585 CDS NP_312510.1 15833737 915575 4526671..4527861 1 NC_002695.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4527861 lldD 915575 lldD Escherichia coli O157:H7 str. Sakai L-lactate dehydrogenase NP_312510.1 4526671 D 386585 CDS NP_312511.1 15833738 915574 4528047..4528520 1 NC_002695.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4528520 915574 ECs4484 Escherichia coli O157:H7 str. Sakai tRNA/rRNA methyltransferase YibK NP_312511.1 4528047 D 386585 CDS NP_312512.1 15833739 915573 complement(4528573..4529394) 1 NC_002695.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4529394 cysE 915573 cysE Escherichia coli O157:H7 str. Sakai serine acetyltransferase NP_312512.1 4528573 R 386585 CDS NP_312513.1 15833740 915571 complement(4529474..4530493) 1 NC_002695.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4530493 gpsA 915571 gpsA Escherichia coli O157:H7 str. Sakai NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_312513.1 4529474 R 386585 CDS NP_312514.1 15833741 915570 complement(4530493..4530960) 1 NC_002695.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4530960 915570 ECs4487 Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecB NP_312514.1 4530493 R 386585 CDS NP_312515.1 15833742 915569 complement(4531023..4531274) 1 NC_002695.1 similar to GRXC_ECOLI gi|1790039 (conserved in Escherichia coli K-12); glutaredoxin 3 4531274 915569 ECs4488 Escherichia coli O157:H7 str. Sakai glutaredoxin 3 NP_312515.1 4531023 R 386585 CDS NP_312516.1 15833743 915568 complement(4531416..4531847) 1 NC_002695.1 similar to YIBN_ECOLI gi|1790040 (conserved in Escherichia coli K-12); hypothetical protein 4531847 915568 ECs4489 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312516.1 4531416 R 386585 CDS NP_312517.1 15833744 915565 4532092..4533636 1 NC_002695.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4533636 915565 ECs4490 Escherichia coli O157:H7 str. Sakai phosphoglyceromutase NP_312517.1 4532092 D 386585 CDS NP_312518.1 15833745 915564 4533646..4534929 1 NC_002695.1 similar to YIBP_ECOLI gi|1790042 (conserved in Escherichia coli K-12); hypothetical protein 4534929 915564 ECs4491 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312518.1 4533646 D 386585 CDS NP_312519.2 38704183 915562 4534933..4535892 1 NC_002695.1 similar to YIBQ_ECOLI gi|1790043 (conserved in Escherichia coli K-12); hypothetical protein 4535892 915562 ECs4492 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312519.2 4534933 D 386585 CDS NP_312520.1 15833747 915561 complement(4535898..4536914) 1 NC_002695.1 similar to YIBD_ECOLI gi|1790044 (conserved in Escherichia coli K-12); glycosyl transferase family protein 4536914 915561 ECs4493 Escherichia coli O157:H7 str. Sakai glycosyl transferase family protein NP_312520.1 4535898 R 386585 CDS NP_312521.1 15833748 915560 complement(4537153..4538178) 1 NC_002695.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4538178 tdh 915560 tdh Escherichia coli O157:H7 str. Sakai L-threonine 3-dehydrogenase NP_312521.1 4537153 R 386585 CDS NP_312522.1 15833749 915559 complement(4538188..4539384) 1 NC_002695.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 4539384 915559 ECs4495 Escherichia coli O157:H7 str. Sakai 2-amino-3-ketobutyrate CoA ligase NP_312522.1 4538188 R 386585 CDS NP_312523.1 15833750 915558 complement(4539659..4540531) 1 NC_002695.1 similar to HTRL_ECOLI gi|1790048 (conserved in Escherichia coli K-12); hypothetical protein 4540531 915558 ECs4496 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312523.1 4539659 R 386585 CDS NP_312524.1 15833751 915557 4540820..4541752 1 NC_002695.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4541752 rfaD 915557 rfaD Escherichia coli O157:H7 str. Sakai ADP-L-glycero-D-manno-heptose-6-epimerase NP_312524.1 4540820 D 386585 CDS NP_312525.1 15833752 915556 4541762..4542808 1 NC_002695.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4542808 915556 ECs4498 Escherichia coli O157:H7 str. Sakai ADP-heptose--LPS heptosyltransferase NP_312525.1 4541762 D 386585 CDS NP_312526.1 15833753 915554 4542812..4543804 1 NC_002695.1 similar to RFAC_ECOLI gi|1790051 (conserved in Escherichia coli K-12); ADP-heptose--LPS heptosyltransferase 4543804 915554 ECs4499 Escherichia coli O157:H7 str. Sakai ADP-heptose--LPS heptosyltransferase NP_312526.1 4542812 D 386585 CDS NP_312527.1 15833754 915553 4543801..4545009 1 NC_002695.1 WaaL; similar to WaaL [Escherichia coli strain F653] gi|3821825|gb|AAC69661.1|; lipid A-core:surface polymer ligase 4545009 915553 ECs4500 Escherichia coli O157:H7 str. Sakai lipid A-core:surface polymer ligase NP_312527.1 4543801 D 386585 CDS NP_312528.1 15833755 915551 complement(4545045..4546187) 1 NC_002695.1 WaaD; similar to WaaD [Escherichia coli strain F653] gi|3821826|gb|AAC69662.1|; lipopolysaccharide 1,2-N- acetylglucosaminetransferase 4546187 915551 ECs4501 Escherichia coli O157:H7 str. Sakai lipopolysaccharide 1,2-N- acetylglucosaminetransferase NP_312528.1 4545045 R 386585 CDS NP_312529.1 15833756 915550 complement(4546196..4547209) 1 NC_002695.1 WaaJ; similar to UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase WaaJ [Escherichia coli strain F653] gi|3821827|gb|AAC69663.1|; UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase 4547209 915550 ECs4502 Escherichia coli O157:H7 str. Sakai UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase NP_312529.1 4546196 R 386585 CDS NP_312530.1 15833757 915549 complement(4547234..4547941) 1 NC_002695.1 similar to WaaY [Escherichia coli strain F653] gi|3821828|gb|AAC69664.1|; lipopolysaccharide core biosynthesis protein 4547941 915549 ECs4503 Escherichia coli O157:H7 str. Sakai lipopolysaccharide core biosynthesis protein NP_312530.1 4547234 R 386585 CDS NP_312531.1 15833758 915548 complement(4547967..4548974) 1 NC_002695.1 similar to WaaI (strain F653 R3 core type) [Escherichia coli] gi|3821829|gb|AAC69665.1; UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase 4548974 915548 ECs4504 Escherichia coli O157:H7 str. Sakai UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase NP_312531.1 4547967 R 386585 CDS NP_312532.2 38704184 915546 complement(4549017..4549814) 1 NC_002695.1 similar to RFAP_ECOLI gi|1790060 (conserved in Escherichia coli K-12); RfaP protein 4549814 915546 ECs4505 Escherichia coli O157:H7 str. Sakai RfaP protein NP_312532.2 4549017 R 386585 CDS NP_312533.1 15833760 915543 complement(4549807..4550931) 1 NC_002695.1 similar to RFAG_ECOLI gi|1790061 (conserved in Escherichia coli K-12); glucosyltransferase I 4550931 915543 ECs4506 Escherichia coli O157:H7 str. Sakai glucosyltransferase I NP_312533.1 4549807 R 386585 CDS NP_312534.2 38704185 915542 complement(4550928..4551950) 1 NC_002695.1 (conserved in Escherichia coli K-12); lipopolysaccharide core biosynthesis protein 4551950 915542 ECs4507 Escherichia coli O157:H7 str. Sakai lipopolysaccharide core biosynthesis protein NP_312534.2 4550928 R 386585 CDS NP_312535.1 15833762 915541 4552399..4553676 1 NC_002695.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4553676 915541 ECs4508 Escherichia coli O157:H7 str. Sakai 3-deoxy-D-manno-octulosonic-acid transferase NP_312535.1 4552399 D 386585 CDS NP_312536.1 15833763 915539 4553684..4554163 1 NC_002695.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4554163 coaD 915539 coaD Escherichia coli O157:H7 str. Sakai phosphopantetheine adenylyltransferase NP_312536.1 4553684 D 386585 CDS NP_312537.1 15833764 915538 complement(4554202..4555011) 1 NC_002695.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4555011 915538 ECs4510 Escherichia coli O157:H7 str. Sakai formamidopyrimidine-DNA glycosylase NP_312537.1 4554202 R 386585 CDS NP_312538.1 15833765 915536 complement(4555109..4555276) 1 NC_002695.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4555276 rpmG 915536 rpmG Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L33 NP_312538.1 4555109 R 386585 CDS NP_312539.1 15833766 915534 complement(4555297..4555533) 1 NC_002695.1 required for 70S ribosome assembly; 50S ribosomal protein L28 4555533 rpmB 915534 rpmB Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L28 NP_312539.1 4555297 R 386585 CDS NP_312540.1 15833767 915533 complement(4555750..4556424) 1 NC_002695.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4556424 radC 915533 radC Escherichia coli O157:H7 str. Sakai DNA repair protein RadC NP_312540.1 4555750 R 386585 CDS NP_312541.2 162139747 915532 4556590..4557810 1 NC_002695.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4557810 915532 ECs4514 Escherichia coli O157:H7 str. Sakai bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_312541.2 4556590 D 386585 CDS NP_312542.1 15833769 915531 4557791..4558246 1 NC_002695.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4558246 dut 915531 dut Escherichia coli O157:H7 str. Sakai deoxyuridine 5'-triphosphate nucleotidohydrolase NP_312542.1 4557791 D 386585 CDS NP_312543.2 38704186 915529 4558353..4558949 1 NC_002695.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4558949 slmA 915529 slmA Escherichia coli O157:H7 str. Sakai nucleoid occlusion protein NP_312543.2 4558353 D 386585 CDS NP_312544.1 15833771 915528 complement(4558986..4559627) 1 NC_002695.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4559627 pyrE 915528 pyrE Escherichia coli O157:H7 str. Sakai orotate phosphoribosyltransferase NP_312544.1 4558986 R 386585 CDS NP_312545.1 15833772 915527 complement(4559693..4560409) 1 NC_002695.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4560409 rph 915527 rph Escherichia coli O157:H7 str. Sakai ribonuclease PH NP_312545.1 4559693 R 386585 CDS NP_312546.1 15833773 915525 4560536..4561399 1 NC_002695.1 similar to YICC_ECOLI gi|1790075 (conserved in Escherichia coli K-12); hypothetical protein 4561399 915525 ECs4519 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312546.1 4560536 D 386585 CDS NP_312547.2 162139746 915524 4561620..4562444 1 NC_002695.1 similar to DIND_ECOLI gi|1790076 (conserved in Escherichia coli K-12); DNA-damage-inducible protein D 4562444 dinD 915524 dinD Escherichia coli O157:H7 str. Sakai DNA-damage-inducible protein D NP_312547.2 4561620 D 386585 CDS NP_312548.2 38704187 915523 4562736..4563353 1 NC_002695.1 similar to YICG_ECOLI gi|1790078 (conserved in Escherichia coli K-12); hypothetical protein 4563353 915523 ECs4521 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312548.2 4562736 D 386585 CDS NP_312549.2 38704188 915522 complement(4563350..4565032) 1 NC_002695.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4565032 ligB 915522 ligB Escherichia coli O157:H7 str. Sakai NAD-dependent DNA ligase LigB NP_312549.2 4563350 R 386585 CDS NP_944568.1 38704189 2693748 complement(4564893..4565150) 1 NC_002695.1 hypothetical protein 4565150 2693748 ECs5537 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944568.1 4564893 R 386585 CDS NP_312550.1 15833777 915521 4565290..4565913 1 NC_002695.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4565913 gmk 915521 gmk Escherichia coli O157:H7 str. Sakai guanylate kinase NP_312550.1 4565290 D 386585 CDS NP_312551.1 15833778 915520 4565968..4566243 1 NC_002695.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4566243 rpoZ 915520 rpoZ Escherichia coli O157:H7 str. Sakai DNA-directed RNA polymerase subunit omega NP_312551.1 4565968 D 386585 CDS NP_312552.1 15833779 915518 4566262..4568370 1 NC_002695.1 similar to SPOT_ECOLI gi|1790082 (conserved in Escherichia coli K-12); bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4568370 915518 ECs4525 Escherichia coli O157:H7 str. Sakai bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase NP_312552.1 4566262 D 386585 CDS NP_312553.1 15833780 915517 4568377..4569066 1 NC_002695.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4569066 915517 ECs4526 Escherichia coli O157:H7 str. Sakai tRNA guanosine-2'-O-methyltransferase NP_312553.1 4568377 D 386585 CDS NP_312554.1 15833781 915516 4569072..4571153 1 NC_002695.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4571153 915516 ECs4527 Escherichia coli O157:H7 str. Sakai ATP-dependent DNA helicase RecG NP_312554.1 4569072 D 386585 CDS NP_312555.1 15833782 915514 complement(4571138..4571656) 1 NC_002695.1 hypothetical protein 4571656 915514 ECs4528 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312555.1 4571138 R 386585 CDS NP_312556.1 15833783 915513 complement(4572007..4573212) 1 NC_002695.1 similar to GLTS_ECOLI gi|1790085 (conserved in Escherichia coli K-12); glutamate transport protein 4573212 915513 ECs4529 Escherichia coli O157:H7 str. Sakai glutamate transport protein NP_312556.1 4572007 R 386585 CDS NP_312557.1 15833784 915511 4573492..4574883 1 NC_002695.1 similar to YICE_ECOLI gi|1790087 (conserved in Escherichia coli K-12); transporter 4574883 915511 ECs4530 Escherichia coli O157:H7 str. Sakai transporter NP_312557.1 4573492 D 386585 CDS NP_312558.1 15833785 915510 4575004..4576713 1 NC_002695.1 similar to YICH_ECOLI gi|1790088 (conserved in Escherichia coli K-12); hypothetical protein 4576713 915510 ECs4531 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312558.1 4575004 D 386585 CDS NP_312559.1 15833786 915508 complement(4576766..4579084) 1 NC_002695.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase 4579084 915508 ECs4532 Escherichia coli O157:H7 str. Sakai alpha-xylosidase NP_312559.1 4576766 R 386585 CDS NP_312560.2 38704190 915507 complement(4579094..4580476) 1 NC_002695.1 may be involved in the transport of galactosides-pentoses-hexuronides; transporter 4580476 915507 ECs4533 Escherichia coli O157:H7 str. Sakai transporter NP_312560.2 4579094 R 386585 CDS NP_312561.1 15833788 915505 4581059..4582240 1 NC_002695.1 similar to CP4-like integrases [Escherichia coli EDL933] gi|3414871|gb|AAC31482.1|, integrases e.g. [Shigella flexneri] gi|5532446|gb|AAD44730.1|AF141323_1; integrase 4582240 915505 ECs4534 Escherichia coli O157:H7 str. Sakai integrase NP_312561.1 4581059 D 386585 CDS NP_312562.1 15833789 915504 4582339..4582689 1 NC_002695.1 similar to L0004 [Escherichia coli strain EDL933] gi|3414872|gb|AAC31483.1|, hypothetical protein [Escherichia coli plasmid pO157 insertion sequence IS911 gi|7465897|pir||T00224; hypothetical protein 4582689 915504 ECs4535 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312562.1 4582339 D 386585 CDS NP_312563.1 15833790 915503 4582702..4582884 1 NC_002695.1 similar to L0005 [Escherichia coli strain EDL933] gi|3414873|gb|AAC31484.1|; hypothetical protein 4582884 915503 ECs4536 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312563.1 4582702 D 386585 CDS NP_312564.1 15833791 915502 4582902..4583555 1 NC_002695.1 similar to L0006 [Escherichia coli strain EDL933] gi|3414874|gb|AAC31485.1|, hypothetical protein [Vibrio cholerae] gi|7960027|gb|AAF71187.1|AF179596_7; hypothetical protein 4583555 915502 ECs4537 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312564.1 4582902 D 386585 CDS NP_312565.1 15833792 915501 4583573..4583716 1 NC_002695.1 similar to C-terminal parts of hypothetical proteins e.g. b2004 (YeeU) [Escherichia coli] gi|3025157|sp|P76364|YEEU_ECOLI; hypothetical protein 4583716 915501 ECs4538 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312565.1 4583573 D 386585 CDS NP_312566.1 15833793 915500 4583806..4584180 1 NC_002695.1 similar to L0007 [Escherichia coli EDL933] gi|3414875|gb|AAC31486.1|, hypothetical proteins e.g. b2005 (yeeV) [Escherichia coli] gi|3025158|sp|P76365|YEEV_ECOLI; hypothetical protein 4584180 915500 ECs4539 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312566.1 4583806 D 386585 CDS NP_312567.1 15833794 915498 4584177..4584668 1 NC_002695.1 similar to L0008 [Escherichia coli EDL933] gi|3414876|gb|AAC31487.1|, hypothetical protein [Escherichia coli D1114, O25:K10:H16] gi|4887094|gb|AAD32187.1|, b2006 (YeeW); hypothetical protein 4584668 915498 ECs4540 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312567.1 4584177 D 386585 CDS NP_312568.1 15833795 915497 4584680..4584877 1 NC_002695.1 similar to L0009 [Escherichia coli strain EDL933] gi|3414877|gb|AAC31488.1|, hypothetical protein [Escherichia coli D1114, O25:K10:H16] gi|4887094|gb|AAD32187.1; hypothetical protein 4584877 915497 ECs4541 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312568.1 4584680 D 386585 CDS NP_312569.1 15833796 915496 4584962..4585303 1 NC_002695.1 similar to L0010 [Escherichia coli strain EDL933] gi|3414878|gb|AAC31489.1|, PH01 [Escherichia coli D1114, O25:K10:H16] gi|4887092|gb|AAD32185.1|AF127177_3; hypothetical protein 4585303 915496 ECs4542 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312569.1 4584962 D 386585 CDS NP_312572.1 15833799 915492 4586059..4586460 1 NC_002695.1 similar to L0013 [Escherichia coli EDL933] gi|3414881|gb|AAC31492.1|, hypothetical proteins e.g. Hp3 [Escherichia coli CFT073] gi|3661484|gb|AAC61715.1|; hypothetical protein 4586460 915492 ECs4545 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312572.1 4586059 D 386585 CDS NP_312573.1 15833800 915490 4586457..4586804 1 NC_002695.1 similar to L0014 [Escherichia coli] gi|3414882|gb|AAC31493.1|, hypothetical proteins e.g. orf50 [Escherichia coli plasmid pB171] gi|6009426|dbj|BAA84885.1|; hypothetical protein 4586804 915490 ECs4546 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312573.1 4586457 D 386585 CDS NP_312574.1 15833801 915489 4586854..4588392 1 NC_002695.1 similar to L0015 [Escherichia coli EDL933] gi|3414883|gb|AAC31494.1|, hypothetical proteins e.g. [Escherichia coli plasmid pEAF] gi|4808945|gb|AAD30027.1|AF119170_2; hypothetical protein 4588392 915489 ECs4547 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312574.1 4586854 D 386585 CDS NP_312575.1 15833802 915488 4588589..4588822 1 NC_002695.1 similar to IS630 insertion element hypothetical protein gi|1143207|gb|AAA84873.1|; hypothetical protein 4588822 915488 ECs4548 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312575.1 4588589 D 386585 CDS NP_312577.1 15833804 915286 complement(4589257..4590003) 1 NC_002695.1 similar to L0016 [Escherichia coli EDL933] gi|3414884|gb|AAC31495.1|, EspF [Escherichia coli E2348/69] gi|2865308|gb|AAC38400.1|; protein EspF 4590003 915286 ECs4550 Escherichia coli O157:H7 str. Sakai protein EspF NP_312577.1 4589257 R 386585 CDS NP_312578.1 15833805 915301 complement(4590088..4590366) 1 NC_002695.1 similar to L0017 [Escherichia coli EDL933] gi|3414885|gb|AAC31496.1|, hypothetical protein [Escherichia coli] gi|2809428|gb|AAC28566.1|; hypothetical protein 4590366 915301 ECs4551 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312578.1 4590088 R 386585 CDS NP_312579.1 15833806 915302 complement(4590372..4590593) 1 NC_002695.1 similar to EscF [Escherichia coli] gi|2865306|gb|AAC38398.1|, L0018 [Escherichia coli EDL933] gi|3414886|gb|AAC31497.1|; protein EscF 4590593 915302 ECs4552 Escherichia coli O157:H7 str. Sakai protein EscF NP_312579.1 4590372 R 386585 CDS NP_312580.1 15833807 915483 complement(4590629..4591036) 1 NC_002695.1 similar to L0019 [Escherichia coli EDL933] gi|3414887|gb|AAC31498.1|, hypothetical proteins e.g. Orf27 [Escherichia coli E2348/69] gi|2865305|gb|AAC38397.1|; hypothetical protein 4591036 915483 ECs4553 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312580.1 4590629 R 386585 CDS NP_312581.1 15833808 915476 complement(4591043..4591981) 1 NC_002695.1 secreted protein; similar to EspB proteins e.g. EspB(L0020) [Escherichia coli EDL933] gi|1657263|emb|CAA65654.1|; protein EspB 4591981 915476 ECs4554 Escherichia coli O157:H7 str. Sakai protein EspB NP_312581.1 4591043 R 386585 CDS NP_312582.1 15833809 915475 complement(4592002..4593126) 1 NC_002695.1 secreted protein; similar to L0021 [Escherichia coli EDL933] gi|3414889|gb|AAC31500.1|, EspD proteins e.g. gi|3688279|emb|CAA76909.1|; protein EspD 4593126 915475 ECs4555 Escherichia coli O157:H7 str. Sakai protein EspD NP_312582.1 4592002 R 386585 CDS NP_312583.1 15833810 915474 complement(4593139..4593717) 1 NC_002695.1 secreted protein; similar to EspA protein (L0022) [Escherichia coli] gi|3115184|emb|CAA73506.1|, EspA proteins e.g. gi|2388623|gb|AAB71083.1|; protein EspA 4593717 915474 ECs4556 Escherichia coli O157:H7 str. Sakai protein EspA NP_312583.1 4593139 R 386585 CDS NP_312584.1 15833811 915473 complement(4593776..4594831) 1 NC_002695.1 similar to SepL (L0023) [Escherichia coli EDL933] gi|3115183|emb|CAA73505.1|, SepL proteins e.g. gi|2865301|gb|AAC38393.1|; type III secretion system protein; SepL 4594831 915473 ECs4557 Escherichia coli O157:H7 str. Sakai SepL NP_312584.1 4593776 R 386585 CDS NP_312585.1 15833812 915472 4594974..4596194 1 NC_002695.1 similar to Pas (L0024) [Escherichia coli EDL933] gi|3115182|emb|CAA73504.1|, EscD proteins e.g. gi|3341420|emb|CAA74170.1|; type III secretion system protein; EscD 4596194 915472 ECs4558 Escherichia coli O157:H7 str. Sakai EscD NP_312585.1 4594974 D 386585 CDS NP_312586.1 15833813 915471 complement(4596458..4599262) 1 NC_002695.1 similar to Gamma intimin (L0025) [Escherichia coli strain EDL933] gi|3414893|gb|AAC31504.1|; gamma intimin 4599262 915471 ECs4559 Escherichia coli O157:H7 str. Sakai gamma intimin NP_312586.1 4596458 R 386585 CDS NP_312587.1 15833814 915463 complement(4599322..4599792) 1 NC_002695.1 chaperon of Tir; similar to CesT [Escherichia coli O157:H7 strain HA1] gi|975876|gb|AAB00110.1|, CesT proteins [Escherichia coli] gi|140611|sp|P21244|YEAE_ECOLI; protein CesT 4599792 915463 ECs4560 Escherichia coli O157:H7 str. Sakai protein CesT NP_312587.1 4599322 R 386585 CDS NP_312588.1 15833815 915465 complement(4599930..4601606) 1 NC_002695.1 similar to translocated intimin receptor Tir (L0027) [Escherichia coli O157:H7 strain EDL933] gi|3414895|gb|AAC31506.1|; hypothetical protein 4601606 915465 ECs4561 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312588.1 4599930 R 386585 CDS NP_312589.1 15833816 915466 complement(4602030..4602641) 1 NC_002695.1 similar to L0028 [Escherichia coli O157:H7 strain EDL933] gi|3414896|gb|AAC31507.1|, hypothetical protein [Escherichia coli] gi|3249026|gb|AAC69313.1|; hypothetical protein 4602641 915466 ECs4562 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312589.1 4602030 R 386585 CDS NP_312590.1 15833817 915468 4602907..4603290 1 NC_002695.1 similar to L0029 [Escherichia coli O157:H7 strain EDL933] gi|3414897|gb|AAC31508.1|, rOrf10 [Escherichia coli] gi|2865295|gb|AAC38388.1|; hypothetical protein 4603290 915468 ECs4563 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312590.1 4602907 D 386585 CDS NP_312591.1 15833818 915470 complement(4603488..4603994) 1 NC_002695.1 similar to L0030 [Escherichia coli O157:H7 strain EDL933] gi|3414898|gb|AAC31509.1|, Orf18 [Escherichia coli] gi|2865294|gb|AAC38387.1|; hypothetical protein 4603994 915470 ECs4564 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312591.1 4603488 R 386585 CDS NP_944569.1 38704191 2693785 4603740..4603943 1 NC_002695.1 hypothetical protein 4603943 2693785 ECs5539 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944569.1 4603740 D 386585 CDS NP_312592.1 15833819 915469 complement(4604025..4604942) 1 NC_002695.1 similar to L0031 [Escherichia coli O157:H7 strain EDL933] gi|3414899|gb|AAC31510.1|, SepQ [Escherichia coli strain E2348/69] gi|2865293|gb|AAC38386.1|; type III secretion system protein; SepQ 4604942 915469 ECs4565 Escherichia coli O157:H7 str. Sakai SepQ NP_312592.1 4604025 R 386585 CDS NP_312593.1 15833820 915467 complement(4604905..4605321) 1 NC_002695.1 similar to Orf16 [Escherichia coli strain E2348/69] gi|2865292|gb|AAC38385.1|, L0032 [Escherichia coli O157:H7 strain EDL933] gi|3414900|gb|AAC31511.1|; hypothetical protein 4605321 915467 ECs4566 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312593.1 4604905 R 386585 CDS NP_312594.1 15833821 915464 complement(4605314..4605691) 1 NC_002695.1 similar to L0033 [Escherichia coli O157:H7 strain EDL933] gi|3414901|gb|AAC31512.1|; hypothetical protein 4605691 915464 ECs4567 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312594.1 4605314 R 386585 CDS NP_312595.1 15833822 915448 complement(4605694..4607034) 1 NC_002695.1 similar to EscN (L00349 [Escherichia coli O157:H7 strain EDL933] gi|3414902|gb|AAC31513.1|; type III secretion system protein; EscN 4607034 915448 ECs4568 Escherichia coli O157:H7 str. Sakai EscN NP_312595.1 4605694 R 386585 CDS NP_312596.1 15833823 915449 complement(4607018..4609045) 1 NC_002695.1 similar to EscV (L0035) [Escherichia coli O157:H7 strain EDL933] gi|3414903|gb|AAC31514.1|; hypothetical protein 4609045 915449 ECs4569 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312596.1 4607018 R 386585 CDS NP_312597.1 15833824 915452 complement(4609042..4609395) 1 NC_002695.1 similar to Orf12 [Escherichia coli strain E2348/69] gi|2865288|gb|AAC38381.1|, L0036 [Escherichia coli O157:H7 strain EDL933] gi|3414904|gb|AAC31515.1|; hypothetical protein 4609395 915452 ECs4570 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312597.1 4609042 R 386585 CDS NP_312598.1 15833825 915454 4609580..4609879 1 NC_002695.1 similar to SepZ proteins e.g. [Escherichia coli O157:H7 strain EDL933] gi|3414905|gb|AAC31516.1|; type III secretion system protein; SepZ 4609879 915454 ECs4571 Escherichia coli O157:H7 str. Sakai SepZ NP_312598.1 4609580 D 386585 CDS NP_312599.1 15833826 915456 4609912..4610340 1 NC_002695.1 similar to L0038 [Escherichia coli O157:H7 strain EDL933] gi|3414906|gb|AAC31517.1|, rOrf8 [Escherichia coli E2348/69] gi|2865287|gb|AAC38380.1|; hypothetical protein 4610340 915456 ECs4572 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312599.1 4609912 D 386585 CDS NP_312600.1 15833827 915458 4610343..4610915 1 NC_002695.1 similar to EscJ [Escherichia coli strain E2348/69] gi|2865286|gb|AAC38379.1|, L0039 (EscJ) [Escherichia coli O157:H7 strain EDL933] gi|3414907|gb|AAC31518.1|; type III secretion system protein; EscJ 4610915 915458 ECs4573 Escherichia coli O157:H7 str. Sakai EscJ NP_312600.1 4610343 D 386585 CDS NP_312601.1 15833828 915462 4610921..4611376 1 NC_002695.1 similar to SepD (L0040) [Escherichia coli O157:H7 strain EDL933] gi|3414908|gb|AAC31519.1|, SepD proteins e.g. [Escherichia coli strain E2348/69] gi|886476|emb|CAA90273.1|; type III secretion system protein; SepD 4611376 915462 ECs4574 Escherichia coli O157:H7 str. Sakai SepD NP_312601.1 4610921 D 386585 CDS NP_312602.1 15833829 915461 4611376..4612914 1 NC_002695.1 similar to EscC (L0041) [Escherichia coli O157:H7 strain EDL933] gi|3414909|gb|AAC31520.1|; type III secretion system protein; EscC 4612914 915461 ECs4575 Escherichia coli O157:H7 str. Sakai EscC NP_312602.1 4611376 D 386585 CDS NP_312603.1 15833830 915460 4612928..4613383 1 NC_002695.1 similar to CesD (L0042) [Escherichia coli O157:H7 strain EDL933] gi|3414910|gb|AAC31521.1|; type III secretion system protein; CesD 4613383 915460 ECs4576 Escherichia coli O157:H7 str. Sakai CesD NP_312603.1 4612928 D 386585 CDS NP_312604.1 15833831 915459 complement(4613767..4614180) 1 NC_002695.1 similar to L0043 [Escherichia coli O157:H7 strain EDL933] gi|3414911|gb|AAC31522.1|, Orf11 [Escherichia coli strain E2348/69] gi|2865282|gb|AAC38375.1|; hypothetical protein 4614180 915459 ECs4577 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312604.1 4613767 R 386585 CDS NP_312605.1 15833832 915455 complement(4614235..4614606) 1 NC_002695.1 similar to L0044 [Escherichia coli O157:H7 strain EDL933] gi|3414912|gb|AAC31523.1|, Orf10 [Escherichia coli strain E2348/69] gi|2865281|gb|AAC38374.1|; negative regulator GrlR 4614606 915455 ECs4578 Escherichia coli O157:H7 str. Sakai negative regulator GrlR NP_312605.1 4614235 R 386585 CDS NP_312606.1 15833833 915453 4614802..4615260 1 NC_002695.1 similar to L0045 [Escherichia coli O157:H7 strain EDL933] gi|3414913|gb|AAC31524.1|, rOrf3 [Escherichia coli strain E2348/69] gi|2865280|gb|AAC38373.1|; hypothetical protein 4615260 915453 ECs4579 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312606.1 4614802 D 386585 CDS NP_312607.1 15833834 915451 complement(4615257..4616294) 1 NC_002695.1 member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli; secretion system apparatus protein SsaU 4616294 915451 ECs4580 Escherichia coli O157:H7 str. Sakai secretion system apparatus protein SsaU NP_312607.1 4615257 R 386585 CDS NP_312608.1 15833835 915450 complement(4616287..4617063) 1 NC_002695.1 similar to EscT (L0047) [Escherichia coli O157:H7 strain EDL933] gi|3414915|gb|AAC31526.1|; type III secretion system protein; EscT 4617063 915450 ECs4581 Escherichia coli O157:H7 str. Sakai EscT NP_312608.1 4616287 R 386585 CDS NP_312609.1 15833836 915447 complement(4617063..4617332) 1 NC_002695.1 similar to EscS (L0048) [Escherichia coli O157:H7 strain EDL933] gi|3414916|gb|AAC31527.1|; type III secretion system protein; EscS 4617332 915447 ECs4582 Escherichia coli O157:H7 str. Sakai EscS NP_312609.1 4617063 R 386585 CDS NP_312610.1 15833837 915446 complement(4617332..4617985) 1 NC_002695.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response; type III secretion system protein 4617985 915446 ECs4583 Escherichia coli O157:H7 str. Sakai type III secretion system protein NP_312610.1 4617332 R 386585 CDS NP_312611.1 15833838 915437 complement(4617990..4618685) 1 NC_002695.1 similar to L0050 [Escherichia coli O157:H7 strain EDL933] gi|3414918|gb|AAC31529.1|, Orf5 [Escherichia coli strain E2348/69] gi|2865275|gb|AAC38368.1|; hypothetical protein 4618685 915437 ECs4584 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312611.1 4617990 R 386585 CDS NP_312612.1 15833839 915441 complement(4618630..4619229) 1 NC_002695.1 similar to L0051 [Escherichia coli O157:H7 strain EDL933] gi|3414919|gb|AAC31530.1|, Orf4 [Escherichia coli strain E2348/69] gi|2865274|gb|AAC38367.1|; hypothetical protein 4619229 915441 ECs4585 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312612.1 4618630 R 386585 CDS NP_312613.1 15833840 915457 complement(4619226..4619549) 1 NC_002695.1 similar to Orf3 [Escherichia coli E2348/69] gi|2865273|gb|AAC38366.1|, L0052 [Escherichia coli O157:H7 strain EDL933] gi|3414920|gb|AAC31531.1|; hypothetical protein 4619549 915457 ECs4586 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312613.1 4619226 R 386585 CDS NP_312614.1 15833841 915444 complement(4619553..4619771) 1 NC_002695.1 similar to Orf2 [Escherichia coli strain E2348/69] gi|2865272|gb|AAC38365.1|, L0053 [Escherichia coli O157:H7 strain EDL933] gi|3414921|gb|AAC31532.1|; hypothetical protein 4619771 915444 ECs4587 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312614.1 4619553 R 386585 CDS NP_312615.1 15833842 915445 complement(4619786..4620175) 1 NC_002695.1 similar to L0054 [Escherichia coli O157:H7 strain EDL933] gi|3414922|gb|AAC31533.1|, Ler [Escherichia coli strain E2348/69] gi|2865271|gb|AAC38364.1|; hypothetical protein 4620175 915445 ECs4588 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312615.1 4619786 R 386585 CDS NP_312617.1 15833844 915442 4621420..4622616 1 NC_002695.1 similar to L0055 [Escherichia coli O157:H7 strain EDL933] gi|3414923|gb|AAC31534.1|, rOrf2, EspG [Escherichia coli strain E2348/69] gi|2865270|gb|AAC38363.1|; protein EspG 4622616 915442 ECs4590 Escherichia coli O157:H7 str. Sakai protein EspG NP_312617.1 4621420 D 386585 CDS NP_312618.1 15833845 915440 4622744..4623562 1 NC_002695.1 similar to L0056 [Escherichia coli O157:H7 strain EDL933] gi|3414924|gb|AAC31535.1|, rOrf1 [Escherichia coli strain E2348/69] gi|2865269|gb|AAC38362.1|; hypothetical protein 4623562 915440 ECs4591 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312618.1 4622744 D 386585 CDS NP_312619.1 15833846 915439 complement(4623876..4624109) 1 NC_002695.1 hypothetical protein 4624109 915439 ECs4592 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312619.1 4623876 R 386585 CDS NP_312620.1 15833847 915438 complement(4624334..4624528) 1 NC_002695.1 hypothetical protein 4624528 915438 ECs4593 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312620.1 4624334 R 386585 CDS NP_312621.1 15833848 915436 4624582..4625505 1 NC_002695.1 similar to YICL_ECOLI gi|1790092 (conserved in Escherichia coli K-12); permease transporter 4625505 915436 ECs4594 Escherichia coli O157:H7 str. Sakai permease transporter NP_312621.1 4624582 D 386585 CDS NP_312622.1 15833849 915435 complement(4625509..4626327) 1 NC_002695.1 similar to NLPA_ECOLI gi|1790093 (conserved in Escherichia coli K-12); hypothetical protein 4626327 915435 ECs4595 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312622.1 4625509 R 386585 CDS NP_944570.1 38704192 2693786 4626480..4626842 1 NC_002695.1 hypothetical protein 4626842 2693786 ECs5540 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944570.1 4626480 D 386585 CDS NP_312623.2 162139745 915429 complement(4626883..4628073) 1 NC_002695.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4628073 nepI 915429 nepI Escherichia coli O157:H7 str. Sakai ribonucleoside transporter NP_312623.2 4626883 R 386585 CDS NP_312624.1 15833851 913046 4628307..4628660 1 NC_002695.1 similar to hypothetical proteins e.g. NMA0565 [Neisseria meningitidis] gi|7379302|emb|CAB83857.1; hypothetical protein 4628660 913046 ECs4597 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312624.1 4628307 D 386585 CDS NP_312625.1 15833852 913063 4628644..4628967 1 NC_002695.1 similar to DNA-binding protein [Neisseria meningitidis] gi|7379301|emb|CAB83856.1; DNA-binding protein 4628967 913063 ECs4598 Escherichia coli O157:H7 str. Sakai DNA-binding protein NP_312625.1 4628644 D 386585 CDS NP_312626.1 15833853 913119 complement(4629083..4629562) 1 NC_002695.1 similar to YICN_ECOLI gi|1790096 (conserved in Escherichia coli K-12); hypothetical protein 4629562 913119 ECs4599 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312626.1 4629083 R 386585 CDS NP_312627.1 15833854 913122 complement(4629588..4630013) 1 NC_002695.1 similar to YICO_ECOLI gi|1790097; hypothetical protein 4630013 913122 ECs4600 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312627.1 4629588 R 386585 CDS NP_312628.1 15833855 915434 complement(4629926..4630999) 1 NC_002695.1 similar to YICO_ECOLI gi|1790097; hypothetical protein 4630999 915434 ECs4601 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312628.1 4629926 R 386585 CDS NP_312629.1 15833856 915433 4631096..4632862 1 NC_002695.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4632862 915433 ECs4602 Escherichia coli O157:H7 str. Sakai cryptic adenine deaminase NP_312629.1 4631096 D 386585 CDS NP_312630.1 15833857 915432 complement(4632908..4634299) 1 NC_002695.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4634299 uhpT 915432 uhpT Escherichia coli O157:H7 str. Sakai sugar phosphate antiporter NP_312630.1 4632908 R 386585 CDS NP_312631.1 15833858 915431 complement(4634437..4635759) 1 NC_002695.1 membrane protein regulates uhpT expression; regulatory protein UhpC 4635759 915431 ECs4604 Escherichia coli O157:H7 str. Sakai regulatory protein UhpC NP_312631.1 4634437 R 386585 CDS NP_312632.2 38704193 915430 complement(4635766..4637268) 1 NC_002695.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4637268 915430 ECs4605 Escherichia coli O157:H7 str. Sakai sensory histidine kinase UhpB NP_312632.2 4635766 R 386585 CDS NP_312633.1 15833860 915428 complement(4637268..4637858) 1 NC_002695.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; UhpA family transcriptional regulator 4637858 915428 ECs4606 Escherichia coli O157:H7 str. Sakai UhpA family transcriptional regulator NP_312633.1 4637268 R 386585 CDS NP_312634.1 15833861 915427 complement(4638020..4639012) 1 NC_002695.1 hypothetical protein 4639012 915427 ECs4607 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312634.1 4638020 R 386585 CDS NP_312635.1 15833862 915426 complement(4639139..4639453) 1 NC_002695.1 hypothetical protein 4639453 915426 ECs4608 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312635.1 4639139 R 386585 CDS NP_312636.1 15833863 915425 complement(4639731..4640213) 1 NC_002695.1 hypothetical protein 4640213 915425 ECs4609 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312636.1 4639731 R 386585 CDS NP_312637.1 15833864 915424 complement(4640361..4641014) 1 NC_002695.1 hypothetical protein 4641014 915424 ECs4610 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312637.1 4640361 R 386585 CDS NP_312638.1 15833865 915423 complement(4641277..4641567) 1 NC_002695.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4641567 915423 ECs4611 Escherichia coli O157:H7 str. Sakai acetolactate synthase 1 regulatory subunit NP_312638.1 4641277 R 386585 CDS NP_312639.1 15833866 915422 complement(4641571..4643259) 1 NC_002695.1 catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase catalytic subunit 4643259 915422 ECs4612 Escherichia coli O157:H7 str. Sakai acetolactate synthase catalytic subunit NP_312639.1 4641571 R 386585 CDS NP_312640.1 15833867 915421 complement(4643365..4643463) 1 NC_002695.1 similar to IVBL_ECOLI gi|1790106 (conserved in Escherichia coli K-12); ilvB operon leader peptide 4643463 915421 ECs4613 Escherichia coli O157:H7 str. Sakai ilvB operon leader peptide NP_312640.1 4643365 R 386585 CDS NP_944571.1 38704194 2693787 4643450..4643740 1 NC_002695.1 hypothetical protein 4643740 2693787 ECs5541 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944571.1 4643450 D 386585 CDS NP_312641.1 15833868 915420 4644391..4645581 1 NC_002695.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4645581 emrD 915420 emrD Escherichia coli O157:H7 str. Sakai multidrug resistance protein D NP_312641.1 4644391 D 386585 CDS NP_312642.1 15833869 915419 complement(4645589..4646086) 1 NC_002695.1 similar to YIDF_ECOLI gi|1790108 (conserved in Escherichia coli K-12); transcriptional regulator 4646086 915419 ECs4615 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_312642.1 4645589 R 386585 CDS NP_312643.1 15833870 915418 complement(4646083..4646445) 1 NC_002695.1 similar to YIDG_ECOLI gi|1790109 (conserved in Escherichia coli K-12); hypothetical protein 4646445 915418 ECs4616 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312643.1 4646083 R 386585 CDS NP_312644.1 15833871 915417 complement(4646435..4646782) 1 NC_002695.1 similar to YIDH_ECOLI gi|1790110 (conserved in Escherichia coli K-12); hypothetical protein 4646782 915417 ECs4617 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312644.1 4646435 R 386585 CDS NP_312645.1 15833872 915415 4646891..4647340 1 NC_002695.1 similar to YIDI_ECOLI gi|1790111 (conserved in Escherichia coli K-12); hypothetical protein 4647340 915415 ECs4618 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312645.1 4646891 D 386585 CDS NP_312646.1 15833873 913018 complement(4647387..4648880) 1 NC_002695.1 similar to YIDJ_ECOLI gi|1790112 (conserved in Escherichia coli K-12); sulfatase 4648880 913018 ECs4619 Escherichia coli O157:H7 str. Sakai sulfatase NP_312646.1 4647387 R 386585 CDS NP_312647.1 15833874 913019 complement(4648877..4650592) 1 NC_002695.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK 4650592 913019 ECs4620 Escherichia coli O157:H7 str. Sakai symporter YidK NP_312647.1 4648877 R 386585 CDS NP_312648.1 15833875 915411 4650729..4651652 1 NC_002695.1 similar to YIDL_ECOLI gi|1790114 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 4651652 915411 ECs4621 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_312648.1 4650729 D 386585 CDS NP_312649.1 15833876 915416 complement(4651649..4652971) 1 NC_002695.1 similar to GLVG_ECOLI gi|1790115 (conserved in Escherichia coli K-12); 6-phospho-beta-glucosidase 4652971 915416 ECs4622 Escherichia coli O157:H7 str. Sakai 6-phospho-beta-glucosidase NP_312649.1 4651649 R 386585 CDS NP_312650.2 38704195 915414 complement(4652971..4654587) 1 NC_002695.1 similar to GLVC_ECOLI gi|1790117 (conserved in Escherichia coli K-12); PTS system arbutin-like IIC component 4654587 915414 ECs4623 Escherichia coli O157:H7 str. Sakai PTS system arbutin-like IIC component NP_312650.2 4652971 R 386585 CDS NP_312651.1 15833878 915413 4654883..4655599 1 NC_002695.1 similar to YIDP_ECOLI gi|1790118 (conserved in Escherichia coli K-12); transcriptional regulator 4655599 915413 ECs4624 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_312651.1 4654883 D 386585 CDS NP_312652.2 38704196 915412 complement(4655596..4657257) 1 NC_002695.1 similar to YIDE_ECOLI gi|1790119 (conserved in Escherichia coli K-12); hypothetical protein 4657257 915412 ECs4625 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312652.2 4655596 R 386585 CDS NP_312653.2 162139744 915410 complement(4657453..4657881) 1 NC_002695.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4657881 915410 ECs4626 Escherichia coli O157:H7 str. Sakai heat shock chaperone IbpB NP_312653.2 4657453 R 386585 CDS NP_312654.1 15833881 915409 complement(4657993..4658406) 1 NC_002695.1 heat shock protein; with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4658406 915409 ECs4627 Escherichia coli O157:H7 str. Sakai heat shock protein IbpA NP_312654.1 4657993 R 386585 CDS NP_312655.2 162139743 915408 4658712..4659044 1 NC_002695.1 similar to YIDQ_ECOLI gi|1790123 (conserved in Escherichia coli K-12); hypothetical protein 4659044 915408 ECs4628 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312655.2 4658712 D 386585 CDS NP_312656.1 15833883 915407 complement(4659046..4660296) 1 NC_002695.1 similar to YIDR_ECOLI gi|1790124 (conserved in Escherichia coli K-12); hypothetical protein 4660296 915407 ECs4629 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312656.1 4659046 R 386585 CDS NP_312657.2 162139742 915406 4660361..4661425 1 NC_002695.1 FAD/NAD(P)-binding domain; oxidoreductase 4661425 915406 ECs4630 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_312657.2 4660361 D 386585 CDS NP_312658.1 15833885 915405 4661671..4662327 1 NC_002695.1 similar YIDX_ECOLI gi|1790130; hypothetical protein 4662327 915405 ECs4631 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312658.1 4661671 D 386585 CDS NP_312659.1 15833886 915404 complement(4662373..4663185) 1 NC_002695.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4663185 915404 ECs4632 Escherichia coli O157:H7 str. Sakai sugar phosphatase NP_312659.1 4662373 R 386585 CDS NP_312660.2 38704197 915403 complement(4663300..4663698) 1 NC_002695.1 similar to YIDB_ECOLI gi|1790133 (conserved in Escherichia coli K-12); hypothetical protein 4663698 915403 ECs4633 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312660.2 4663300 R 386585 CDS NP_312661.1 15833888 915402 complement(4663938..4666352) 1 NC_002695.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4666352 gyrB 915402 gyrB Escherichia coli O157:H7 str. Sakai DNA gyrase subunit B NP_312661.1 4663938 R 386585 CDS NP_312662.1 15833889 915400 complement(4666381..4667454) 1 NC_002695.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4667454 recF 915400 recF Escherichia coli O157:H7 str. Sakai recombination protein F NP_312662.1 4666381 R 386585 CDS NP_312663.1 15833890 915391 complement(4667454..4668554) 1 NC_002695.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4668554 915391 ECs4636 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit beta NP_312663.1 4667454 R 386585 CDS NP_312664.1 15833891 913016 complement(4668559..4669962) 1 NC_002695.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 4669962 dnaA 913016 dnaA Escherichia coli O157:H7 str. Sakai chromosomal replication initiation protein NP_312664.1 4668559 R 386585 CDS NP_312665.1 15833892 915396 4670569..4670709 1 NC_002695.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4670709 rpmH 915396 rpmH Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L34 NP_312665.1 4670569 D 386585 CDS NP_312666.1 15833893 915401 4670726..4671085 1 NC_002695.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4671085 rnpA 915401 rnpA Escherichia coli O157:H7 str. Sakai ribonuclease P NP_312666.1 4670726 D 386585 CDS NP_312667.1 15833894 915399 4671309..4672955 1 NC_002695.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4672955 915399 ECs4640 Escherichia coli O157:H7 str. Sakai inner membrane protein translocase component YidC NP_312667.1 4671309 D 386585 CDS NP_312668.1 15833895 915398 4673061..4674425 1 NC_002695.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4674425 trmE 915398 trmE Escherichia coli O157:H7 str. Sakai tRNA modification GTPase TrmE NP_312668.1 4673061 D 386585 CDS NP_312669.1 15833896 915397 complement(4674575..4674805) 1 NC_002695.1 hypothetical protein 4674805 915397 ECs4642 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312669.1 4674575 R 386585 CDS NP_312670.1 15833897 915395 complement(4674756..4676744) 1 NC_002695.1 similar to ankyrin-like regulatory protein [Escherichia coli] gi|418526|sp|P23325|APR_ECOLI, ShET2 enterotoxin [Shigella flexneri] gi|1109754|emb|CAA90938.1|; hypothetical protein 4676744 915395 ECs4643 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312670.1 4674756 R 386585 CDS NP_312671.1 15833898 915394 4677144..4677218 1 NC_002695.1 similar to TNAL_ECOLI gi|1790143 (conserved in Escherichia coli K-12); tryptophanase leader peptide 4677218 915394 ECs4644 Escherichia coli O157:H7 str. Sakai tryptophanase leader peptide NP_312671.1 4677144 D 386585 CDS NP_312672.2 38704198 915393 4677439..4678854 1 NC_002695.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4678854 tnaA 915393 tnaA Escherichia coli O157:H7 str. Sakai tryptophanase NP_312672.2 4677439 D 386585 CDS NP_312673.1 15833900 915392 4678945..4680192 1 NC_002695.1 tryptophan transporter of low affinity; tryptophan permease TnaB 4680192 915392 ECs4646 Escherichia coli O157:H7 str. Sakai tryptophan permease TnaB NP_312673.1 4678945 D 386585 CDS NP_312674.1 15833901 915390 4680324..4681499 1 NC_002695.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4681499 915390 ECs4647 Escherichia coli O157:H7 str. Sakai multidrug efflux system protein MdtL NP_312674.1 4680324 D 386585 CDS NP_312675.1 15833902 915377 4681474..4682433 1 NC_002695.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4682433 915377 ECs4648 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator YidZ NP_312675.1 4681474 D 386585 CDS NP_312676.1 15833903 915379 4682578..4683339 1 NC_002695.1 similar to YIEE_ECOLI gi|1790148 (conserved in Escherichia coli K-12); hypothetical protein 4683339 915379 ECs4649 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312676.1 4682578 D 386585 CDS NP_312677.1 15833904 915385 4683361..4683927 1 NC_002695.1 similar to YIEF_ECOLI gi|1790149 (conserved in Escherichia coli K-12); hypothetical protein 4683927 915385 ECs4650 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312677.1 4683361 D 386585 CDS NP_312678.1 15833905 915383 complement(4683981..4685318) 1 NC_002695.1 similar to YIEG_ECOLI gi|1790150 (conserved in Escherichia coli K-12); membrane/transport protein 4685318 915383 ECs4651 Escherichia coli O157:H7 str. Sakai membrane/transport protein NP_312678.1 4683981 R 386585 CDS NP_312679.1 15833906 915386 4685484..4686149 1 NC_002695.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4686149 915386 ECs4652 Escherichia coli O157:H7 str. Sakai 6-phosphogluconate phosphatase NP_312679.1 4685484 D 386585 CDS NP_312680.1 15833907 915389 complement(4686286..4688694) 1 NC_002695.1 similar to hypothetical protein [Plasmodium falciparum] gi|8052285|emb|CAB39037.2|, restriction-modification enzyme R subunits [Mycoplasma pulmonis] e.g. gi|1363459|pir||S49394; hypothetical protein 4688694 915389 ECs4653 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312680.1 4686286 R 386585 CDS NP_312681.1 15833908 915388 4688995..4689666 1 NC_002695.1 hypothetical protein 4689666 915388 ECs4654 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312681.1 4688995 D 386585 CDS NP_312682.1 15833909 915387 4689712..4690182 1 NC_002695.1 hypothetical protein 4690182 915387 ECs4655 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312682.1 4689712 D 386585 CDS NP_312683.1 15833910 915384 complement(4690281..4690460) 1 NC_002695.1 hypothetical protein 4690460 915384 ECs4656 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312683.1 4690281 R 386585 CDS NP_312684.1 15833911 915382 complement(4690651..4693035) 1 NC_002695.1 similar to hypothetical protein [Plasmodium falciparum] gi|8052290|emb|CAB39073.2|; hypothetical protein 4693035 915382 ECs4657 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312684.1 4690651 R 386585 CDS NP_944572.1 38704199 2693784 complement(4693117..4693323) 1 NC_002695.1 hypothetical protein 4693323 2693784 ECs5542 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944572.1 4693117 R 386585 CDS NP_312686.1 15833913 915380 complement(4693425..4693604) 1 NC_002695.1 hypothetical protein 4693604 915380 ECs4659 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312686.1 4693425 R 386585 CDS NP_312687.1 15833914 915378 complement(4693561..4694286) 1 NC_002695.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4694286 915378 ECs4660 Escherichia coli O157:H7 str. Sakai transcriptional regulator PhoU NP_312687.1 4693561 R 386585 CDS NP_312688.1 15833915 915370 complement(4694301..4695074) 1 NC_002695.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4695074 pstB 915370 pstB Escherichia coli O157:H7 str. Sakai phosphate transporter ATP-binding protein NP_312688.1 4694301 R 386585 CDS NP_312689.1 15833916 915367 complement(4695257..4696147) 1 NC_002695.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PtsA 4696147 pstA 915367 pstA Escherichia coli O157:H7 str. Sakai phosphate transporter permease PtsA NP_312689.1 4695257 R 386585 CDS NP_312690.1 15833917 915372 complement(4696147..4697106) 1 NC_002695.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PstC 4697106 pstC 915372 pstC Escherichia coli O157:H7 str. Sakai phosphate transporter permease PstC NP_312690.1 4696147 R 386585 CDS NP_312691.1 15833918 915373 complement(4697193..4698233) 1 NC_002695.1 similar to PSTS_ECOLI gi|2367271 (conserved in Escherichia coli K-12); phosphate ABC transporter substrate-binding protein 4698233 915373 ECs4664 Escherichia coli O157:H7 str. Sakai phosphate ABC transporter substrate-binding protein NP_312691.1 4697193 R 386585 CDS NP_312692.1 15833919 915374 complement(4698445..4699527) 1 NC_002695.1 similar to fimbrial proteins e.g. [Salmonella typhimurium] gi|1170818|sp|P43663|LPFD_SALTY, [Escherichia coli] gi|3915422|sp|P75858|YCBT_ECOLI; fimbrial protein 4699527 915374 ECs4665 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_312692.1 4698445 R 386585 CDS NP_312693.1 15833920 915376 complement(4699555..4700625) 1 NC_002695.1 similar to fimbrial proteins e.g. [Escherichia coli] gi|3915422|sp|P75858|YCBT_ECOLI, [Salmonella typhimurium] gi|1170818|sp|P43663|LPFD_SALTY; fimbrial protein 4700625 915376 ECs4666 Escherichia coli O157:H7 str. Sakai fimbrial protein NP_312693.1 4699555 R 386585 CDS NP_312694.1 15833921 915375 complement(4700637..4703171) 1 NC_002695.1 similar to outer membrane usher protein precursors e.g. [Salmonella typhimurium] gi|1170817|sp|P43662|LPFC_SALTY, [Escherichia coli] gi|2829634|sp|P75857|YCBS_ECOLI; outer membrane usher protein 4703171 915375 ECs4667 Escherichia coli O157:H7 str. Sakai outer membrane usher protein NP_312694.1 4700637 R 386585 CDS NP_312695.1 15833922 915371 complement(4703193..4703354) 1 NC_002695.1 similar to fimbrial chaperone e.g. gi|1169720|sp|P46008|FOCC_ECOLI; hypothetical protein 4703354 915371 ECs4668 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312695.1 4703193 R 386585 CDS NP_312696.1 15833923 915369 complement(4703495..4703878) 1 NC_002695.1 similar to fimbrial chaperones e.g. [Salmonella typhimurium] gi|1170816|sp|P43661|LPFB_SALTY; fimbrial chaperone 4703878 915369 ECs4669 Escherichia coli O157:H7 str. Sakai fimbrial chaperone NP_312696.1 4703495 R 386585 CDS NP_312697.1 15833924 915368 complement(4703982..4704584) 1 NC_002695.1 similar to type 1 fimbrial proteins e.g. [Salmonella enteritidis] gi|913907|gb|AAB33536.1|; type 1 fimbrial protein 4704584 915368 ECs4670 Escherichia coli O157:H7 str. Sakai type 1 fimbrial protein NP_312697.1 4703982 R 386585 CDS NP_312698.1 15833925 915347 complement(4705284..4707113) 1 NC_002695.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4707113 915347 ECs4671 Escherichia coli O157:H7 str. Sakai glucosamine--fructose-6-phosphate aminotransferase NP_312698.1 4705284 R 386585 CDS NP_312699.1 15833926 915349 complement(4707275..4708645) 1 NC_002695.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4708645 glmU 915349 glmU Escherichia coli O157:H7 str. Sakai bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_312699.1 4707275 R 386585 CDS NP_312700.1 15833927 915356 complement(4708997..4709416) 1 NC_002695.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 4709416 atpC 915356 atpC Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit epsilon NP_312700.1 4708997 R 386585 CDS NP_312701.1 15833928 915359 complement(4709437..4710819) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The subunit beta is a regulatory subunit; ATP synthase F0F1 subunit beta 4710819 915359 ECs4674 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit beta NP_312701.1 4709437 R 386585 CDS NP_312702.1 15833929 915357 complement(4710846..4711709) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 4711709 915357 ECs4675 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit gamma NP_312702.1 4710846 R 386585 CDS NP_312703.1 15833930 915345 complement(4711760..4713301) 1 NC_002695.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the subunit alpha is a catalytic subunit; ATP synthase F0F1 subunit alpha 4713301 915345 ECs4676 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit alpha NP_312703.1 4711760 R 386585 CDS NP_312704.1 15833931 913118 complement(4713314..4713847) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 4713847 913118 ECs4677 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit delta NP_312704.1 4713314 R 386585 CDS NP_312705.1 15833932 915334 complement(4713862..4714332) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 4714332 915334 ECs4678 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit B NP_312705.1 4713862 R 386585 CDS NP_312706.1 15833933 915336 complement(4714394..4714633) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 4714633 915336 ECs4679 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit C NP_312706.1 4714394 R 386585 CDS NP_312707.1 15833934 915337 complement(4714680..4715495) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 4715495 915337 ECs4680 Escherichia coli O157:H7 str. Sakai ATP synthase F0F1 subunit A NP_312707.1 4714680 R 386585 CDS NP_312708.2 162139741 915341 complement(4715504..4715884) 1 NC_002695.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4715884 915341 ECs4681 Escherichia coli O157:H7 str. Sakai F0F1 ATP synthase subunit I NP_312708.2 4715504 R 386585 CDS NP_312709.1 15833936 915344 complement(4716501..4717124) 1 NC_002695.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4717124 gidB 915344 gidB Escherichia coli O157:H7 str. Sakai 16S rRNA methyltransferase GidB NP_312709.1 4716501 R 386585 CDS NP_312710.1 15833937 915333 complement(4717188..4719077) 1 NC_002695.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 4719077 915333 ECs4683 Escherichia coli O157:H7 str. Sakai tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_312710.1 4717188 R 386585 CDS NP_312711.1 15833938 915324 complement(4719456..4719899) 1 NC_002695.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4719899 915324 ECs4684 Escherichia coli O157:H7 str. Sakai flavodoxin NP_312711.1 4719456 R 386585 CDS NP_312712.1 15833939 915327 complement(4719989..4720447) 1 NC_002695.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; AsnC family transcriptional regulator 4720447 915327 ECs4685 Escherichia coli O157:H7 str. Sakai AsnC family transcriptional regulator NP_312712.1 4719989 R 386585 CDS NP_312713.1 15833940 915329 4720599..4721591 1 NC_002695.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4721591 915329 ECs4686 Escherichia coli O157:H7 str. Sakai asparagine synthetase AsnA NP_312713.1 4720599 D 386585 CDS NP_312714.1 15833941 915332 complement(4721596..4723047) 1 NC_002695.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4723047 yieM 915332 yieM Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312714.1 4721596 R 386585 CDS NP_312715.2 38704200 915331 complement(4723041..4724537) 1 NC_002695.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4724537 915331 ECs4688 Escherichia coli O157:H7 str. Sakai regulatory ATPase RavA NP_312715.2 4723041 R 386585 CDS NP_312716.1 15833943 915317 4724760..4726628 1 NC_002695.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4726628 trkD 915317 trkD Escherichia coli O157:H7 str. Sakai potassium transport protein Kup NP_312716.1 4724760 D 386585 CDS NP_312717.1 15833944 915320 4726795..4727214 1 NC_002695.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4727214 915320 ECs4690 Escherichia coli O157:H7 str. Sakai D-ribose pyranase NP_312717.1 4726795 D 386585 CDS NP_312718.1 15833945 915326 4727222..4728727 1 NC_002695.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; sugar ABC transporter ATP-binding protein 4728727 915326 ECs4691 Escherichia coli O157:H7 str. Sakai sugar ABC transporter ATP-binding protein NP_312718.1 4727222 D 386585 CDS NP_312719.1 15833946 915328 4728732..4729697 1 NC_002695.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4729697 rbsC 915328 rbsC Escherichia coli O157:H7 str. Sakai ribose ABC transporter permease NP_312719.1 4728732 D 386585 CDS NP_312720.1 15833947 915325 4729722..4730612 1 NC_002695.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4730612 915325 ECs4693 Escherichia coli O157:H7 str. Sakai D-ribose transporter subunit RbsB NP_312720.1 4729722 D 386585 CDS NP_312721.1 15833948 915323 4730738..4731667 1 NC_002695.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4731667 915323 ECs4694 Escherichia coli O157:H7 str. Sakai ribokinase NP_312721.1 4730738 D 386585 CDS NP_312722.1 15833949 915322 4731671..4732663 1 NC_002695.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4732663 915322 ECs4695 Escherichia coli O157:H7 str. Sakai transcriptional repressor RbsR NP_312722.1 4731671 D 386585 CDS NP_312723.1 15833950 915321 complement(4732629..4734056) 1 NC_002695.1 similar to YIEO_ECOLI gi|1790195 (conserved in Escherichia coli K-12); transporter 4734056 915321 ECs4696 Escherichia coli O157:H7 str. Sakai transporter NP_312723.1 4732629 R 386585 CDS NP_312724.2 38704201 915315 complement(4734079..4734771) 1 NC_002695.1 similar to YIEP_ECOLI gi|1790196 (conserved in Escherichia coli K-12); hypothetical protein 4734771 915315 ECs4697 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312724.2 4734079 R 386585 CDS NP_312725.1 15833952 915303 complement(4740572..4741411) 1 NC_002695.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4741411 915303 ECs4698 Escherichia coli O157:H7 str. Sakai transcriptional regulator HdfR NP_312725.1 4740572 R 386585 CDS NP_312726.1 15833953 915294 4741530..4741868 1 NC_002695.1 similar to YIFE_ECOLI gi|2367277 (conserved in Escherichia coli K-12); hypothetical protein 4741868 915294 ECs4699 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312726.1 4741530 D 386585 CDS NP_312727.1 15833954 915293 complement(4741893..4743443) 1 NC_002695.1 among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease 4743443 915293 ECs4700 Escherichia coli O157:H7 str. Sakai ATP-dependent protease NP_312727.1 4741893 R 386585 CDS NP_312728.1 15833955 915291 4743766..4743864 1 NC_002695.1 similar to ILVL_ECOLI gi|1790202 (conserved in Escherichia coli K-12); ilvG operon leader peptide 4743864 915291 ECs4701 Escherichia coli O157:H7 str. Sakai ilvG operon leader peptide NP_312728.1 4743766 D 386585 CDS NP_312729.1 15833956 915287 4744004..4745650 1 NC_002695.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4745650 915287 ECs4702 Escherichia coli O157:H7 str. Sakai acetolactate synthase 2 catalytic subunit NP_312729.1 4744004 D 386585 CDS NP_312730.1 15833957 915285 4745647..4745910 1 NC_002695.1 similar to ILVM_ECOLI gi|1790204 (conserved in Escherichia coli K-12); acetolactate synthase 2 regulatory subunit 4745910 ilvM 915285 ilvM Escherichia coli O157:H7 str. Sakai acetolactate synthase 2 regulatory subunit NP_312730.1 4745647 D 386585 CDS NP_312731.1 15833958 915283 4745930..4746859 1 NC_002695.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4746859 915283 ECs4704 Escherichia coli O157:H7 str. Sakai branched-chain amino acid aminotransferase NP_312731.1 4745930 D 386585 CDS NP_312732.1 15833959 915282 4746924..4748774 1 NC_002695.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4748774 915282 ECs4705 Escherichia coli O157:H7 str. Sakai dihydroxy-acid dehydratase NP_312732.1 4746924 D 386585 CDS NP_312733.1 15833960 915279 4748777..4750321 1 NC_002695.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4750321 915279 ECs4706 Escherichia coli O157:H7 str. Sakai threonine dehydratase NP_312733.1 4748777 D 386585 CDS NP_312734.1 15833961 915274 complement(4750373..4751266) 1 NC_002695.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4751266 915274 ECs4707 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator IlvY NP_312734.1 4750373 R 386585 CDS NP_312735.1 15833962 915271 4751416..4752891 1 NC_002695.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4752891 915271 ECs4708 Escherichia coli O157:H7 str. Sakai ketol-acid reductoisomerase NP_312735.1 4751416 D 386585 CDS NP_312736.1 15833963 915269 complement(4752937..4753218) 1 NC_002695.1 similar to PPIC_ECOLI gi|1790211 (conserved in Escherichia coli K-12); peptidyl-prolyl cis-trans isomerase C 4753218 915269 ECs4709 Escherichia coli O157:H7 str. Sakai peptidyl-prolyl cis-trans isomerase C NP_312736.1 4752937 R 386585 CDS NP_312737.1 15833964 915266 complement(4753417..4753866) 1 NC_002695.1 similar to YIFN_ECOLI gi|2367280, b3776_ECOLI gi|2367279; hypothetical protein 4753866 915266 ECs4710 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312737.1 4753417 R 386585 CDS NP_312738.1 15833965 915261 4754083..4756104 1 NC_002695.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4756104 915261 ECs4711 Escherichia coli O157:H7 str. Sakai ATP-dependent DNA helicase Rep NP_312738.1 4754083 D 386585 CDS NP_312739.1 15833966 915259 complement(4756151..4757635) 1 NC_002695.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4757635 915259 ECs4712 Escherichia coli O157:H7 str. Sakai guanosine pentaphosphate phosphohydrolase NP_312739.1 4756151 R 386585 CDS NP_312740.1 15833967 915257 complement(4757771..4759036) 1 NC_002695.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4759036 915257 ECs4713 Escherichia coli O157:H7 str. Sakai ATP-dependent RNA helicase RhlB NP_312740.1 4757771 R 386585 CDS NP_312741.1 15833968 915255 4759113..4759496 1 NC_002695.1 similar to TRXA_ECOLI gi|1790215 (conserved in Escherichia coli K-12); thioredoxin 4759496 trxA 915255 trxA Escherichia coli O157:H7 str. Sakai thioredoxin NP_312741.1 4759113 D 386585 CDS NP_312742.1 15833969 915252 4759637..4759738 1 NC_002695.1 similar to RHOL_ECOLI gi|1790216 (conserved in Escherichia coli K-12); rho operon leader peptide 4759738 915252 ECs4715 Escherichia coli O157:H7 str. Sakai rho operon leader peptide NP_312742.1 4759637 D 386585 CDS NP_312743.1 15833970 915249 4759823..4761082 1 NC_002695.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4761082 rho 915249 rho Escherichia coli O157:H7 str. Sakai transcription termination factor Rho NP_312743.1 4759823 D 386585 CDS NP_944573.1 38704202 2693761 4761092..4761310 1 NC_002695.1 hypothetical protein 4761310 2693761 ECs5549 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944573.1 4761092 D 386585 CDS NP_312744.1 15833971 915248 4761322..4762425 1 NC_002695.1 similar to RFE_ECOLI gi|1790218 (conserved in Escherichia coli K-12); UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4762425 915248 ECs4717 Escherichia coli O157:H7 str. Sakai UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase NP_312744.1 4761322 D 386585 CDS NP_312745.1 15833972 915243 4762434..4763483 1 NC_002695.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4763483 915243 ECs4718 Escherichia coli O157:H7 str. Sakai lipopolysaccharide biosynthesis protein WzzE NP_312745.1 4762434 D 386585 CDS NP_312746.1 15833973 915240 4763497..4764669 1 NC_002695.1 similar to WECB_ECOLI gi|2367283 (conserved in Escherichia coli K-12); UDP-N-acetylglucosamine 2-epimerase 4764669 915240 ECs4719 Escherichia coli O157:H7 str. Sakai UDP-N-acetylglucosamine 2-epimerase NP_312746.1 4763497 D 386585 CDS NP_312747.1 15833974 915235 4764666..4765928 1 NC_002695.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4765928 wecC 915235 wecC Escherichia coli O157:H7 str. Sakai UDP-N-acetyl-D-mannosamine dehydrogenase NP_312747.1 4764666 D 386585 CDS NP_312748.1 15833975 915233 4765928..4766995 1 NC_002695.1 similar to RFFG_ECOLI gi|1790223 (conserved in Escherichia coli K-12); dTDP-glucose 4,6-dehydratase 4766995 915233 ECs4721 Escherichia coli O157:H7 str. Sakai dTDP-glucose 4,6-dehydratase NP_312748.1 4765928 D 386585 CDS NP_312749.1 15833976 915232 4767014..4767895 1 NC_002695.1 similar to RFFH_ECOLI gi|1790224 (conserved in Escherichia coli K-12); glucose-1-phosphate thymidylyltransferase 4767895 915232 ECs4722 Escherichia coli O157:H7 str. Sakai glucose-1-phosphate thymidylyltransferase NP_312749.1 4767014 D 386585 CDS NP_312750.1 15833977 915226 4768002..4768547 1 NC_002695.1 similar to WECD_ECOLI gi|1790225 (conserved in Escherichia coli K-12); TDP-fucosamine acetyltransferase 4768547 915226 ECs4723 Escherichia coli O157:H7 str. Sakai TDP-fucosamine acetyltransferase NP_312750.1 4768002 D 386585 CDS NP_312751.1 15833978 915225 4768552..4769682 1 NC_002695.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4769682 915225 ECs4724 Escherichia coli O157:H7 str. Sakai TDP-4-oxo-6-deoxy-D-glucose transaminase NP_312751.1 4768552 D 386585 CDS NP_312752.1 15833979 915223 4769684..4770934 1 NC_002695.1 similar to WZXE_ECOLI gi|1790227 (conserved in Escherichia coli K-12); cytochrome 4770934 915223 ECs4725 Escherichia coli O157:H7 str. Sakai cytochrome NP_312752.1 4769684 D 386585 CDS NP_312753.1 15833980 915126 4770931..4772010 1 NC_002695.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4772010 915126 ECs4726 Escherichia coli O157:H7 str. Sakai 4-alpha-L-fucosyltransferase NP_312753.1 4770931 D 386585 CDS NP_312754.1 15833981 915114 4772007..4773359 1 NC_002695.1 enterobacterial common antigen polymerase; common antigen polymerase 4773359 915114 ECs4727 Escherichia coli O157:H7 str. Sakai common antigen polymerase NP_312754.1 4772007 D 386585 CDS NP_312755.1 15833982 915133 4773362..4774102 1 NC_002695.1 similar to WECG_ECOLI gi|2367289 (conserved in Escherichia coli K-12); UDP-N-acetyl-D-mannosaminuronic acid transferase 4774102 915133 ECs4728 Escherichia coli O157:H7 str. Sakai UDP-N-acetyl-D-mannosaminuronic acid transferase NP_312755.1 4773362 D 386585 CDS NP_312756.1 15833983 915167 4774293..4775678 1 NC_002695.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4775678 915167 ECs4729 Escherichia coli O157:H7 str. Sakai transporter NP_312756.1 4774293 D 386585 CDS NP_312757.1 15833984 915197 4776589..4777824 1 NC_002695.1 similar to ASLB_ECOLI gi|2367292 (conserved in Escherichia coli K-12); arylsulfatase 4777824 915197 ECs4730 Escherichia coli O157:H7 str. Sakai arylsulfatase NP_312757.1 4776589 D 386585 CDS NP_312758.1 15833985 915195 complement(4777992..4779647) 1 NC_002695.1 similar to ASLA_ECOLI gi|1790233 (conserved in Escherichia coli K-12); arylsulfatase 4779647 915195 ECs4731 Escherichia coli O157:H7 str. Sakai arylsulfatase NP_312758.1 4777992 R 386585 CDS NP_312759.1 15833986 915180 complement(4780326..4781522) 1 NC_002695.1 similar to HEMY_ECOLI gi|1790234 (conserved in Escherichia coli K-12); protoheme IX biogenesis protein 4781522 915180 ECs4732 Escherichia coli O157:H7 str. Sakai protoheme IX biogenesis protein NP_312759.1 4780326 R 386585 CDS NP_312760.1 15833987 915182 complement(4781525..4782724) 1 NC_002695.1 similar to HEMX_ECOLI gi|1790235; uroporphyrinogen III C-methyltransferase 4782724 915182 ECs4733 Escherichia coli O157:H7 str. Sakai uroporphyrinogen III C-methyltransferase NP_312760.1 4781525 R 386585 CDS NP_312761.1 15833988 915187 complement(4782746..4783486) 1 NC_002695.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4783486 hemD 915187 hemD Escherichia coli O157:H7 str. Sakai uroporphyrinogen-III synthase NP_312761.1 4782746 R 386585 CDS NP_312762.1 15833989 915188 complement(4783483..4784445) 1 NC_002695.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4784445 hemC 915188 hemC Escherichia coli O157:H7 str. Sakai porphobilinogen deaminase NP_312762.1 4783483 R 386585 CDS NP_312763.1 15833990 915191 4784811..4787357 1 NC_002695.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4787357 cyaA 915191 cyaA Escherichia coli O157:H7 str. Sakai adenylate cyclase NP_312763.1 4784811 D 386585 CDS NP_312764.1 15833991 915190 complement(4787397..4787717) 1 NC_002695.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4787717 cyaY 915190 cyaY Escherichia coli O157:H7 str. Sakai frataxin-like protein NP_312764.1 4787397 R 386585 CDS NP_312765.1 15833992 915189 4787508..4787993 1 NC_002695.1 similar to B3808_ECOLI gi|1790240 (conserved in Escherichia coli K-12); hypothetical protein 4787993 915189 ECs4737 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312765.1 4787508 D 386585 CDS NP_944574.1 38704203 2693762 4788180..4788383 1 NC_002695.1 hypothetical protein 4788383 2693762 ECs5556 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944574.1 4788180 D 386585 CDS NP_312766.2 162139740 915186 4788420..4789244 1 NC_002695.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4789244 dapF 915186 dapF Escherichia coli O157:H7 str. Sakai diaminopimelate epimerase NP_312766.2 4788420 D 386585 CDS NP_312767.1 15833994 915185 4789241..4789948 1 NC_002695.1 similar to YIGA_ECOLI gi|1790243 (conserved in Escherichia coli K-12); hypothetical protein 4789948 915185 ECs4740 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312767.1 4789241 D 386585 CDS NP_312768.1 15833995 912638 4789945..4790841 1 NC_002695.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4790841 xerC 912638 xerC Escherichia coli O157:H7 str. Sakai site-specific tyrosine recombinase XerC NP_312768.1 4789945 D 386585 CDS NP_312769.1 15833996 912640 4790841..4791557 1 NC_002695.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4791557 912640 ECs4742 Escherichia coli O157:H7 str. Sakai flavin mononucleotide phosphatase NP_312769.1 4790841 D 386585 CDS NP_312770.1 15833997 915330 4791641..4793803 1 NC_002695.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4793803 uvrD 915330 uvrD Escherichia coli O157:H7 str. Sakai DNA-dependent helicase II NP_312770.1 4791641 D 386585 CDS NP_312771.1 15833998 915184 complement(4793848..4794750) 1 NC_002695.1 similar to conserved hypothetical proteins e.g. HP0709 [Helicobacter pylori 26695] gi|7463979|pir||E64608; hypothetical protein 4794750 915184 ECs4744 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312771.1 4793848 R 386585 CDS NP_312772.1 15833999 915183 complement(4794833..4795597) 1 NC_002695.1 similar to YIGE_ECOLI gi|1790248, B3814_ECOLI gi|1790247; hypothetical protein 4795597 915183 ECs4745 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312772.1 4794833 R 386585 CDS NP_312773.1 15834000 915181 4795967..4796917 1 NC_002695.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4796917 915181 ECs4746 Escherichia coli O157:H7 str. Sakai magnesium/nickel/cobalt transporter CorA NP_312773.1 4795967 D 386585 CDS NP_312774.1 15834001 915174 complement(4797447..4798295) 1 NC_002695.1 similar to hypothetical protein [Xylella fastidiosa] gi|9104946|gb|AAF82968.1|AE003869_5; hypothetical protein 4798295 915174 ECs4747 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312774.1 4797447 R 386585 CDS NP_312775.1 15834002 915352 4799255..4799554 1 NC_002695.1 hypothetical protein 4799554 915352 ECs4748 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312775.1 4799255 D 386585 CDS NP_312776.1 15834003 915312 complement(4799601..4800488) 1 NC_002695.1 similar to RARD_ECOLI gi|1790252 (conserved in Escherichia coli K-12); hypothetical protein 4800488 915312 ECs4749 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312776.1 4799601 R 386585 CDS NP_312777.2 38704204 915155 complement(4800540..4801007) 1 NC_002695.1 similar to YIGI_ECOLI gi|2367298 (conserved in Escherichia coli K-12); hypothetical protein 4801007 915155 ECs4750 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312777.2 4800540 R 386585 CDS NP_312778.1 15834005 915153 4801172..4802041 1 NC_002695.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4802041 915153 ECs4751 Escherichia coli O157:H7 str. Sakai phospholipase A NP_312778.1 4801172 D 386585 CDS NP_312779.1 15834006 915152 4802168..4804003 1 NC_002695.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4804003 915152 ECs4752 Escherichia coli O157:H7 str. Sakai ATP-dependent DNA helicase RecQ NP_312779.1 4802168 D 386585 CDS NP_312780.1 15834007 915151 4804067..4804687 1 NC_002695.1 similar to RHTC_ECOLI gi|2851443|sp|P27846 (conserved in Escherichia coli K-12); threonine efflux system 4804687 915151 ECs4753 Escherichia coli O157:H7 str. Sakai threonine efflux system NP_312780.1 4804067 D 386585 CDS NP_312781.1 15834008 915150 complement(4804749..4805369) 1 NC_002695.1 similar to RHTB_ECOLI gi|6093972|sp|P27847 (conserved in Escherichia coli K-12); homoserine/homoserine lactone efflux protein 4805369 rhtB 915150 rhtB Escherichia coli O157:H7 str. Sakai homoserine/homoserine lactone efflux protein NP_312781.1 4804749 R 386585 CDS NP_312782.1 15834009 915149 4805480..4806502 1 NC_002695.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4806502 915149 ECs4755 Escherichia coli O157:H7 str. Sakai lysophospholipase L2 NP_312782.1 4805480 D 386585 CDS NP_312783.1 15834010 915148 4806510..4807310 1 NC_002695.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4807310 915148 ECs4756 Escherichia coli O157:H7 str. Sakai sugar phosphatase NP_312783.1 4806510 D 386585 CDS NP_312784.1 15834011 915147 4807386..4808285 1 NC_002695.1 similar to YIGM_ECOLI gi|1790261 (conserved in Escherichia coli K-12); hypothetical protein 4808285 915147 ECs4757 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312784.1 4807386 D 386585 CDS NP_312785.1 15834012 915146 complement(4808173..4809126) 1 NC_002695.1 similar to METR_ECOLI gi|1790262 (conserved in Escherichia coli K-12); regulator for metE and metH 4809126 915146 ECs4758 Escherichia coli O157:H7 str. Sakai regulator for metE and metH NP_312785.1 4808173 R 386585 CDS NP_312786.1 15834013 915145 4809362..4811623 1 NC_002695.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 4811623 915145 ECs4759 Escherichia coli O157:H7 str. Sakai 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase NP_312786.1 4809362 D 386585 CDS NP_312787.1 15834014 915144 complement(4811663..4812544) 1 NC_002695.1 similar to YSGA_ECOLI gi|2367305; hypothetical protein 4812544 915144 ECs4760 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312787.1 4811663 R 386585 CDS NP_312788.1 15834015 915143 4812740..4813501 1 NC_002695.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4813501 915143 ECs4761 Escherichia coli O157:H7 str. Sakai uridine phosphorylase NP_312788.1 4812740 D 386585 CDS NP_312789.1 15834016 915142 4813642..4815069 1 NC_002695.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4815069 915142 ECs4762 Escherichia coli O157:H7 str. Sakai DNA recombination protein RmuC NP_312789.1 4813642 D 386585 CDS NP_312790.1 15834017 915141 4815164..4815919 1 NC_002695.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4815919 ubiE 915141 ubiE Escherichia coli O157:H7 str. Sakai ubiquinone/menaquinone biosynthesis methyltransferase NP_312790.1 4815164 D 386585 CDS NP_312791.1 15834018 915140 4815933..4816538 1 NC_002695.1 similar to YIGP_ECOLI gi|2367308 (conserved in Escherichia coli K-12); hypothetical protein 4816538 915140 ECs4764 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312791.1 4815933 D 386585 CDS NP_312792.1 15834019 915139 4816535..4818175 1 NC_002695.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4818175 ubiB 915139 ubiB Escherichia coli O157:H7 str. Sakai ubiquinone biosynthesis protein UbiB NP_312792.1 4816535 D 386585 CDS NP_312793.1 15834020 915138 4818254..4818523 1 NC_002695.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 4818523 tatA 915138 tatA Escherichia coli O157:H7 str. Sakai twin arginine translocase A NP_312793.1 4818254 D 386585 CDS NP_312794.1 15834021 915137 4818527..4819042 1 NC_002695.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4819042 915137 ECs4767 Escherichia coli O157:H7 str. Sakai sec-independent translocase NP_312794.1 4818527 D 386585 CDS NP_312795.1 15834022 915136 4819045..4819821 1 NC_002695.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4819821 915136 ECs4768 Escherichia coli O157:H7 str. Sakai twin-arginine protein translocation system subunit TatC NP_312795.1 4819045 D 386585 CDS NP_312796.1 15834023 915135 4819863..4820645 1 NC_002695.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4820645 915135 ECs4769 Escherichia coli O157:H7 str. Sakai DNase TatD NP_312796.1 4819863 D 386585 CDS NP_312797.1 15834024 915134 complement(4820642..4821130) 1 NC_002695.1 transcriptional activator; similar to RFAH_ECOLI gi|1790276 (conserved in Escherichia coli K-12); transcriptional activator RfaH 4821130 rfaH 915134 rfaH Escherichia coli O157:H7 str. Sakai transcriptional activator RfaH NP_312797.1 4820642 R 386585 CDS NP_312798.1 15834025 915132 4821297..4822790 1 NC_002695.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4822790 915132 ECs4771 Escherichia coli O157:H7 str. Sakai 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_312798.1 4821297 D 386585 CDS NP_312799.1 15834026 915131 4822836..4823537 1 NC_002695.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4823537 fre 915131 fre Escherichia coli O157:H7 str. Sakai FMN reductase NP_312799.1 4822836 D 386585 CDS NP_312800.1 15834027 915130 complement(4823729..4824892) 1 NC_002695.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4824892 fadA 915130 fadA Escherichia coli O157:H7 str. Sakai 3-ketoacyl-CoA thiolase NP_312800.1 4823729 R 386585 CDS NP_312801.1 15834028 915128 complement(4824902..4827091) 1 NC_002695.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4827091 fadB 915128 fadB Escherichia coli O157:H7 str. Sakai multifunctional fatty acid oxidation complex subunit alpha NP_312801.1 4824902 R 386585 CDS NP_312802.1 15834029 915127 4827281..4828612 1 NC_002695.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4828612 915127 ECs4775 Escherichia coli O157:H7 str. Sakai proline dipeptidase NP_312802.1 4827281 D 386585 CDS NP_312803.2 38704205 916139 4828612..4829226 1 NC_002695.1 similar to YIGZ_ECOLI gi|1790283 (conserved in Escherichia coli K-12); hypothetical protein 4829226 916139 ECs4776 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312803.2 4828612 D 386585 CDS NP_312804.1 15834031 915125 4829265..4830716 1 NC_002695.1 similar to TRKH_ECOLI gi|2367317, TRKH_ECOLI SW: P21166 (conserved in Escherichia coli K-12); potassium transporter 4830716 915125 ECs4777 Escherichia coli O157:H7 str. Sakai potassium transporter NP_312804.1 4829265 D 386585 CDS NP_312805.1 15834032 915124 4830728..4831273 1 NC_002695.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4831273 hemG 915124 hemG Escherichia coli O157:H7 str. Sakai protoporphyrinogen oxidase NP_312805.1 4830728 D 386585 CDS NP_312806.1 15834033 915118 complement(4836858..4837370) 1 NC_002695.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4837370 915118 ECs4779 Escherichia coli O157:H7 str. Sakai molybdopterin-guanine dinucleotide biosynthesis protein B NP_312806.1 4836858 R 386585 CDS NP_312807.1 15834034 915117 complement(4837367..4837951) 1 NC_002695.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4837951 mobA 915117 mobA Escherichia coli O157:H7 str. Sakai molybdopterin-guanine dinucleotide biosynthesis protein MobA NP_312807.1 4837367 R 386585 CDS NP_312808.1 15834035 915116 4838021..4838290 1 NC_002695.1 similar to YIHD_ECOLI gi|1790289 (conserved in Escherichia coli K-12); hypothetical protein 4838290 915116 ECs4781 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312808.1 4838021 D 386585 CDS NP_312809.1 15834036 915109 4838367..4839353 1 NC_002695.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4839353 915109 ECs4782 Escherichia coli O157:H7 str. Sakai serine/threonine protein kinase NP_312809.1 4838367 D 386585 CDS NP_312810.1 15834037 915115 4839370..4839996 1 NC_002695.1 similar to DSBA_ECOLI gi|1790291 (conserved in Escherichia coli K-12); protein disulfide isomerase I 4839996 915115 ECs4783 Escherichia coli O157:H7 str. Sakai protein disulfide isomerase I NP_312810.1 4839370 D 386585 CDS NP_312811.2 38704206 915113 4840151..4841581 1 NC_002695.1 similar to YIHF_ECOLI gi|2367319 (conserved in Escherichia coli K-12); hypothetical protein 4841581 915113 ECs4784 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312811.2 4840151 D 386585 CDS NP_312812.1 15834039 915112 complement(4841622..4842554) 1 NC_002695.1 similar to YIHG_ECOLI gi|1790293 (conserved in Escherichia coli K-12); acyltransferase 4842554 915112 ECs4785 Escherichia coli O157:H7 str. Sakai acyltransferase NP_312812.1 4841622 R 386585 CDS NP_944575.1 38704207 2693763 complement(4842674..4842916) 1 NC_002695.1 hypothetical protein 4842916 2693763 ECs5562 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944575.1 4842674 R 386585 CDS NP_312813.1 15834040 915111 4842918..4845704 1 NC_002695.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4845704 915111 ECs4786 Escherichia coli O157:H7 str. Sakai DNA polymerase I NP_312813.1 4842918 D 386585 CDS NP_312814.1 15834041 915108 complement(4846086..4846718) 1 NC_002695.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4846718 engB 915108 engB Escherichia coli O157:H7 str. Sakai ribosome biogenesis GTP-binding protein YsxC NP_312814.1 4846086 R 386585 CDS NP_312815.1 15834042 915107 4847300..4847806 1 NC_002695.1 similar to YIHI_ECOLI gi|1790297 (conserved in Escherichia coli K-12); hypothetical protein 4847806 915107 ECs4788 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312815.1 4847300 D 386585 CDS NP_312816.2 38704208 915106 4847995..4849368 1 NC_002695.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4849368 915106 ECs4789 Escherichia coli O157:H7 str. Sakai coproporphyrinogen III oxidase NP_312816.2 4847995 D 386585 CDS NP_312817.1 15834044 915105 complement(4849780..4851189) 1 NC_002695.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4851189 glnG 915105 glnG Escherichia coli O157:H7 str. Sakai nitrogen regulation protein NR(I) NP_312817.1 4849780 R 386585 CDS NP_312818.1 15834045 915104 complement(4851201..4852250) 1 NC_002695.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4852250 glnL 915104 glnL Escherichia coli O157:H7 str. Sakai nitrogen regulation protein NR(II) NP_312818.1 4851201 R 386585 CDS NP_312819.1 15834046 915103 complement(4852424..4853833) 1 NC_002695.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4853833 glnA 915103 glnA Escherichia coli O157:H7 str. Sakai glutamine synthetase NP_312819.1 4852424 R 386585 CDS NP_312820.1 15834047 915102 4854206..4856029 1 NC_002695.1 similar to YIHK_ECOLI gi|1790302 (conserved in Escherichia coli K-12); GTP-binding protein 4856029 915102 ECs4793 Escherichia coli O157:H7 str. Sakai GTP-binding protein NP_312820.1 4854206 D 386585 CDS NP_312821.1 15834048 915101 4856246..4856956 1 NC_002695.1 similar to YIHL_ECOLI gi|1790304 (conserved in Escherichia coli K-12); transcriptional regulator 4856956 915101 ECs4794 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_312821.1 4856246 D 386585 CDS NP_312822.1 15834049 915100 4856964..4857944 1 NC_002695.1 similar to YIHM_ECOLI gi|1790305 (conserved in Escherichia coli K-12); hypothetical protein 4857944 915100 ECs4795 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312822.1 4856964 D 386585 CDS NP_312823.1 15834050 915099 4858046..4859311 1 NC_002695.1 similar to YIHN_ECOLI gi|1790306 (conserved in Escherichia coli K-12); resistance protein 4859311 915099 ECs4796 Escherichia coli O157:H7 str. Sakai resistance protein NP_312823.1 4858046 D 386585 CDS NP_312824.2 229544778 915088 complement(4859402..4860094) 1 NC_002695.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 4860094 ompL 915088 ompL Escherichia coli O157:H7 str. Sakai outer membrane porin L NP_312824.2 4859402 R 386585 CDS NP_312825.1 15834052 915093 complement(4860161..4861564) 1 NC_002695.1 similar to YIHO_ECOLI gi|2367321 (conserved in Escherichia coli K-12); permease 4861564 915093 ECs4798 Escherichia coli O157:H7 str. Sakai permease NP_312825.1 4860161 R 386585 CDS NP_312826.1 15834053 915096 complement(4861607..4862992) 1 NC_002695.1 similar to YIHP_ECOLI gi|2367322 (conserved in Escherichia coli K-12); permease 4862992 915096 ECs4799 Escherichia coli O157:H7 str. Sakai permease NP_312826.1 4861607 R 386585 CDS NP_312827.1 15834054 915098 complement(4863038..4865074) 1 NC_002695.1 similar to YIHQ_ECOLI gi|2367323 (conserved in Escherichia coli K-12); alpha-glucosidase 4865074 915098 ECs4800 Escherichia coli O157:H7 str. Sakai alpha-glucosidase NP_312827.1 4863038 R 386585 CDS NP_312828.1 15834055 915097 complement(4865182..4866057) 1 NC_002695.1 similar to membrane protein [Staphylococcus aureus] gi|3676428|gb|AAC61946.1; hypothetical protein 4866057 915097 ECs4801 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312828.1 4865182 R 386585 CDS NP_312829.1 15834056 915089 complement(4866118..4867020) 1 NC_002695.1 similar to YIHR_ECOLI gi|1790311 (conserved in Escherichia coli K-12); aldose-1-epimerase 4867020 915089 ECs4802 Escherichia coli O157:H7 str. Sakai aldose-1-epimerase NP_312829.1 4866118 R 386585 CDS NP_312830.1 15834057 915091 complement(4867087..4868328) 1 NC_002695.1 similar to YIHS_ECOLI gi|1790313 (conserved in Escherichia coli K-12); hypothetical protein 4868328 915091 ECs4803 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312830.1 4867087 R 386585 CDS NP_312831.1 15834058 915094 complement(4868344..4869222) 1 NC_002695.1 similar to YIHT_ECOLI gi|1790314 (conserved in Escherichia coli K-12); aldolase 4869222 915094 ECs4804 Escherichia coli O157:H7 str. Sakai aldolase NP_312831.1 4868344 R 386585 CDS NP_312832.1 15834059 915095 complement(4869246..4870142) 1 NC_002695.1 similar to YIHU_ECOLI gi|1790315 (conserved in Escherichia coli K-12); dehydrogenase 4870142 915095 ECs4805 Escherichia coli O157:H7 str. Sakai dehydrogenase NP_312832.1 4869246 R 386585 CDS NP_312833.1 15834060 916219 4870304..4871206 1 NC_002695.1 similar to YIHV_ECOLI gi|1790316 (conserved in Escherichia coli K-12); kinase 4871206 916219 ECs4806 Escherichia coli O157:H7 str. Sakai kinase NP_312833.1 4870304 D 386585 CDS NP_312834.1 15834061 915075 4871216..4872025 1 NC_002695.1 similar to YIHW_ECOLI gi|1790317 (conserved in Escherichia coli K-12); DeoR family transcriptional regulator 4872025 915075 ECs4807 Escherichia coli O157:H7 str. Sakai DeoR family transcriptional regulator NP_312834.1 4871216 D 386585 CDS NP_312835.2 38704209 915090 4872124..4872723 1 NC_002695.1 similar to YIHX_ECOLI gi|1790318 (conserved in Escherichia coli K-12); phosphatase 4872723 915090 ECs4808 Escherichia coli O157:H7 str. Sakai phosphatase NP_312835.2 4872124 D 386585 CDS NP_312836.1 15834063 915086 4872717..4873589 1 NC_002695.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4873589 rbn 915086 rbn Escherichia coli O157:H7 str. Sakai ribonuclease BN NP_312836.1 4872717 D 386585 CDS NP_312837.1 15834064 915087 4873586..4874023 1 NC_002695.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4874023 915087 ECs4810 Escherichia coli O157:H7 str. Sakai D-tyrosyl-tRNA(Tyr) deacylase NP_312837.1 4873586 D 386585 CDS NP_312838.1 15834065 915092 4874020..4875009 1 NC_002695.1 similar to YIID_ECOLI gi|1790321 (conserved in Escherichia coli K-12); acetyltransferase 4875009 915092 ECs4811 Escherichia coli O157:H7 str. Sakai acetyltransferase NP_312838.1 4874020 D 386585 CDS NP_312839.1 15834066 915081 4875420..4876313 1 NC_002695.1 hypothetical protein 4876313 915081 ECs4812 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312839.1 4875420 D 386585 CDS NP_312840.1 15834067 915082 4876320..4877234 1 NC_002695.1 hypothetical protein 4877234 915082 ECs4813 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312840.1 4876320 D 386585 CDS NP_312841.1 15834068 915083 complement(4877407..4877625) 1 NC_002695.1 hypothetical protein 4877625 915083 ECs4814 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312841.1 4877407 R 386585 CDS NP_312842.1 15834069 915084 4877901..4878146 1 NC_002695.1 similar to YIIE_ECOLI gi|1790322 (conserved in Escherichia coli K-12); hypothetical protein 4878146 915084 ECs4815 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312842.1 4877901 D 386585 CDS NP_312843.1 15834070 915076 4878363..4878605 1 NC_002695.1 similar to YIIF_ECOLI gi|1790323 (conserved in Escherichia coli K-12); hypothetical protein 4878605 915076 ECs4816 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312843.1 4878363 D 386585 CDS NP_312844.1 15834071 915077 complement(4878935..4879864) 1 NC_002695.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4879864 915077 ECs4817 Escherichia coli O157:H7 str. Sakai formate dehydrogenase accessory protein FdhE NP_312844.1 4878935 R 386585 CDS NP_312845.1 15834072 915078 complement(4879861..4880496) 1 NC_002695.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4880496 915078 ECs4818 Escherichia coli O157:H7 str. Sakai formate dehydrogenase-O subunit gamma NP_312845.1 4879861 R 386585 CDS NP_312846.1 15834073 915080 complement(4880493..4881395) 1 NC_002695.1 similar to FDOH_ECOLI gi|1790326 (conserved in Escherichia coli K-12); formate dehydrogenase-O iron-sulfur subunit 4881395 915080 ECs4819 Escherichia coli O157:H7 str. Sakai formate dehydrogenase-O iron-sulfur subunit NP_312846.1 4880493 R 386585 CDS NP_312847.1 15834074 915079 complement(4881408..4884458) 1 NC_002695.1 similar to FDOG_ECOLI gi|3868719 (conserved in Escherichia coli K-12); formate dehydrogenase-O major subunit 4884458 915079 ECs4820 Escherichia coli O157:H7 str. Sakai formate dehydrogenase-O major subunit NP_312847.1 4881408 R 386585 CDS NP_312848.1 15834075 915071 4884652..4885485 1 NC_002695.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4885485 915071 ECs4821 Escherichia coli O157:H7 str. Sakai formate dehydrogenase accessory protein NP_312848.1 4884652 D 386585 CDS NP_312849.1 15834076 915072 4885638..4886693 1 NC_002695.1 similar to YIIG_ECOLI gi|1790330 (conserved in Escherichia coli K-12); hypothetical protein 4886693 915072 ECs4822 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312849.1 4885638 D 386585 CDS NP_312850.1 15834077 915073 complement(4886743..4888491) 1 NC_002695.1 repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein 4888491 915073 ECs4823 Escherichia coli O157:H7 str. Sakai frv operon regulatory protein NP_312850.1 4886743 R 386585 CDS NP_312851.1 15834078 915074 complement(4888491..4889561) 1 NC_002695.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 4889561 915074 ECs4824 Escherichia coli O157:H7 str. Sakai fructose-specific phosphotransferase system protein FrvX NP_312851.1 4888491 R 386585 CDS NP_312852.1 15834079 915066 complement(4889551..4890990) 1 NC_002695.1 similar to PTVB_ECOLI gi|1790333 (conserved in Escherichia coli K-12); PTS system transporter subunits IIBC 4890990 915066 ECs4825 Escherichia coli O157:H7 str. Sakai PTS system transporter subunits IIBC NP_312852.1 4889551 R 386585 CDS NP_312853.1 15834080 915068 complement(4891001..4891447) 1 NC_002695.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 4891447 915068 ECs4826 Escherichia coli O157:H7 str. Sakai fructose-like phosphotransferase system subunit EIIA NP_312853.1 4891001 R 386585 CDS NP_312854.1 15834081 915069 4891925..4893319 1 NC_002695.1 similar to RafY [Escherichia coli plasmid pRSD2] gi|1773072|gb|AAB71432.1; glycoprotein 4893319 915069 ECs4827 Escherichia coli O157:H7 str. Sakai glycoprotein NP_312854.1 4891925 D 386585 CDS NP_312855.1 15834082 915070 complement(4893360..4893674) 1 NC_002695.1 similar to YIIL_ECOLI gi|1790335 (conserved in Escherichia coli K-12); hypothetical protein 4893674 915070 ECs4828 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312855.1 4893360 R 386585 CDS NP_312856.1 15834083 915067 complement(4893684..4894508) 1 NC_002695.1 similar to RHAD_ECOLI gi|1790336 (conserved in Escherichia coli K-12); rhamnulose-1-phosphate aldolase 4894508 915067 ECs4829 Escherichia coli O157:H7 str. Sakai rhamnulose-1-phosphate aldolase NP_312856.1 4893684 R 386585 CDS NP_312857.1 15834084 915061 complement(4894683..4895942) 1 NC_002695.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4895942 915061 ECs4830 Escherichia coli O157:H7 str. Sakai L-rhamnose isomerase NP_312857.1 4894683 R 386585 CDS NP_312858.1 15834085 915063 complement(4895939..4897408) 1 NC_002695.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4897408 rhaB 915063 rhaB Escherichia coli O157:H7 str. Sakai rhamnulokinase NP_312858.1 4895939 R 386585 CDS NP_312859.1 15834086 915064 4897696..4898532 1 NC_002695.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4898532 915064 ECs4832 Escherichia coli O157:H7 str. Sakai transcriptional activator RhaS NP_312859.1 4897696 D 386585 CDS NP_312860.1 15834087 915065 4898516..4899454 1 NC_002695.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4899454 915065 ECs4833 Escherichia coli O157:H7 str. Sakai transcriptional activator RhaR NP_312860.1 4898516 D 386585 CDS NP_312861.2 38704210 916147 4900764..4901390 1 NC_002695.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4901390 916147 ECs4834 Escherichia coli O157:H7 str. Sakai superoxide dismutase NP_312861.2 4900764 D 386585 CDS NP_312862.2 162139739 914956 4901650..4902633 1 NC_002695.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4902633 914956 ECs4835 Escherichia coli O157:H7 str. Sakai 2-keto-3-deoxygluconate permease NP_312862.2 4901650 D 386585 CDS NP_312863.2 162139738 915037 4902782..4903456 1 NC_002695.1 similar to YIIM_ECOLI gi|1790345 (conserved in Escherichia coli K-12); hypothetical protein 4903456 915037 ECs4836 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312863.2 4902782 D 386585 CDS NP_312864.1 15834091 914983 complement(4903562..4904935) 1 NC_002695.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4904935 cpxA 914983 cpxA Escherichia coli O157:H7 str. Sakai two-component sensor protein NP_312864.1 4903562 R 386585 CDS NP_312865.1 15834092 915041 complement(4904932..4905630) 1 NC_002695.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; CpxR family transcriptional regulator 4905630 915041 ECs4838 Escherichia coli O157:H7 str. Sakai CpxR family transcriptional regulator NP_312865.1 4904932 R 386585 CDS NP_312866.2 162139737 915059 4905780..4906280 1 NC_002695.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4906280 cpxP 915059 cpxP Escherichia coli O157:H7 str. Sakai repressor CpxP NP_312866.2 4905780 D 386585 CDS NP_312867.1 15834094 915062 4906429..4907331 1 NC_002695.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4907331 fieF 915062 fieF Escherichia coli O157:H7 str. Sakai ferrous iron efflux protein F NP_312867.1 4906429 D 386585 CDS NP_312868.1 15834095 915060 4907512..4908474 1 NC_002695.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4908474 pfkA 915060 pfkA Escherichia coli O157:H7 str. Sakai 6-phosphofructokinase NP_312868.1 4907512 D 386585 CDS NP_944576.1 38704211 2693828 complement(4908583..4908765) 1 NC_002695.1 hypothetical protein 4908765 2693828 ECs5564 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944576.1 4908583 R 386585 CDS NP_312869.1 15834096 915053 4908793..4909782 1 NC_002695.1 similar to SBP_ECOLI gi|1790351 (conserved in Escherichia coli K-12); sulfate transporter subunit 4909782 915053 ECs4842 Escherichia coli O157:H7 str. Sakai sulfate transporter subunit NP_312869.1 4908793 D 386585 CDS NP_312870.1 15834097 915054 4909889..4910644 1 NC_002695.1 similar to CDH_ECOLI gi|1790352 (conserved in Escherichia coli K-12); CDP-diacylglycerol pyrophosphatase 4910644 915054 ECs4843 Escherichia coli O157:H7 str. Sakai CDP-diacylglycerol pyrophosphatase NP_312870.1 4909889 D 386585 CDS NP_312871.1 15834098 915057 complement(4910699..4911466) 1 NC_002695.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4911466 tpiA 915057 tpiA Escherichia coli O157:H7 str. Sakai triosephosphate isomerase NP_312871.1 4910699 R 386585 CDS NP_312872.1 15834099 915058 complement(4911574..4912173) 1 NC_002695.1 similar to YIIQ_ECOLI gi|1790354 (conserved in Escherichia coli K-12); hypothetical protein 4912173 915058 ECs4845 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312872.1 4911574 R 386585 CDS NP_312873.1 15834100 915056 4912274..4912714 1 NC_002695.1 similar to YIIR_ECOLI gi|1790355 (conserved in Escherichia coli K-12); hypothetical protein 4912714 915056 ECs4846 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312873.1 4912274 D 386585 CDS NP_312874.1 15834101 915047 4912926..4913225 1 NC_002695.1 similar to YIIS_ECOLI gi|1790357 (conserved in Escherichia coli K-12); hypothetical protein 4913225 915047 ECs4847 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312874.1 4912926 D 386585 CDS NP_312875.1 15834102 915045 4913252..4913680 1 NC_002695.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4913680 915045 ECs4848 Escherichia coli O157:H7 str. Sakai universal stress protein UspD NP_312875.1 4913252 D 386585 CDS NP_312876.1 15834103 915048 complement(4913685..4914431) 1 NC_002695.1 similar to FPR_ECOLI gi|1790359 (conserved in Escherichia coli K-12); ferredoxin-NADP reductase 4914431 915048 ECs4849 Escherichia coli O157:H7 str. Sakai ferredoxin-NADP reductase NP_312876.1 4913685 R 386585 CDS NP_312877.1 15834104 915049 complement(4914528..4915538) 1 NC_002695.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4915538 glpX 915049 glpX Escherichia coli O157:H7 str. Sakai fructose 1,6-bisphosphatase II NP_312877.1 4914528 R 386585 CDS NP_312878.1 15834105 915050 complement(4915768..4917276) 1 NC_002695.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4917276 glpK 915050 glpK Escherichia coli O157:H7 str. Sakai glycerol kinase NP_312878.1 4915768 R 386585 CDS NP_312879.1 15834106 915039 complement(4917299..4918144) 1 NC_002695.1 similar to GLPF_ECOLI gi|1790362 (conserved in Escherichia coli K-12); glycerol facilitator protein 4918144 915039 ECs4852 Escherichia coli O157:H7 str. Sakai glycerol facilitator protein NP_312879.1 4917299 R 386585 CDS NP_312880.2 38704212 915040 4918576..4918815 1 NC_002695.1 similar to YIIU_ECOLI gi|1790363 (conserved in Escherichia coli K-12); hypothetical protein 4918815 915040 ECs4853 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312880.2 4918576 D 386585 CDS NP_312881.1 15834108 915043 complement(4918854..4919570) 1 NC_002695.1 hypothetical protein 4919570 915043 ECs4854 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312881.1 4918854 R 386585 CDS NP_312882.1 15834109 915044 complement(4919603..4920277) 1 NC_002695.1 hypothetical protein 4920277 915044 ECs4855 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312882.1 4919603 R 386585 CDS NP_312883.1 15834110 915029 complement(4920337..4920822) 1 NC_002695.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4920822 915029 ECs4856 Escherichia coli O157:H7 str. Sakai ribonuclease activity regulator protein RraA NP_312883.1 4920337 R 386585 CDS NP_312884.1 15834111 915030 complement(4920915..4921841) 1 NC_002695.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4921841 915030 ECs4857 Escherichia coli O157:H7 str. Sakai 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_312884.1 4920915 R 386585 CDS NP_312885.1 15834112 915031 complement(4921908..4923239) 1 NC_002695.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding protein HslU 4923239 hslU 915031 hslU Escherichia coli O157:H7 str. Sakai ATP-dependent protease ATP-binding protein HslU NP_312885.1 4921908 R 386585 CDS NP_312886.1 15834113 915032 complement(4923249..4923779) 1 NC_002695.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4923779 915032 ECs4859 Escherichia coli O157:H7 str. Sakai ATP-dependent protease peptidase subunit NP_312886.1 4923249 R 386585 CDS NP_312887.1 15834114 915034 complement(4923872..4924831) 1 NC_002695.1 similar to FTSN_ECOLI gi|1790368 (conserved in Escherichia coli K-12); cell division protein FtsN 4924831 915034 ECs4860 Escherichia coli O157:H7 str. Sakai cell division protein FtsN NP_312887.1 4923872 R 386585 CDS NP_312888.1 15834115 915035 complement(4924923..4925948) 1 NC_002695.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4925948 915035 ECs4861 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator CytR NP_312888.1 4924923 R 386585 CDS NP_312889.1 15834116 915025 complement(4926104..4928302) 1 NC_002695.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4928302 915025 ECs4862 Escherichia coli O157:H7 str. Sakai primosome assembly protein PriA NP_312889.1 4926104 R 386585 CDS NP_312890.1 15834117 915027 4928505..4928717 1 NC_002695.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4928717 rpmE 915027 rpmE Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L31 NP_312890.1 4928505 D 386585 CDS NP_312891.1 15834118 915028 4928877..4933061 1 NC_002695.1 RhsH core protein with extension; similar to Rhs proteins e.g. RhsF [Escherichia coli] gi|2920637|gb|AAC32473.1|; protein RhsH 4933061 915028 ECs4864 Escherichia coli O157:H7 str. Sakai protein RhsH NP_312891.1 4928877 D 386585 CDS NP_944577.1 38704213 2693829 4933352..4933630 1 NC_002695.1 hypothetical protein 4933630 2693829 ECs5565 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944577.1 4933352 D 386585 CDS NP_312892.1 15834119 915022 4934070..4934363 1 NC_002695.1 hypothetical protein 4934363 915022 ECs4865 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312892.1 4934070 D 386585 CDS NP_312893.1 15834120 915023 complement(4934292..4934900) 1 NC_002695.1 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 4934900 915023 ECs4866 Escherichia coli O157:H7 str. Sakai peptidoglycan peptidase NP_312893.1 4934292 R 386585 CDS NP_312894.1 15834121 915024 complement(4934960..4935277) 1 NC_002695.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4935277 915024 ECs4867 Escherichia coli O157:H7 str. Sakai transcriptional repressor protein MetJ NP_312894.1 4934960 R 386585 CDS NP_312895.1 15834122 915015 4935554..4936714 1 NC_002695.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4936714 915015 ECs4868 Escherichia coli O157:H7 str. Sakai cystathionine gamma-synthase NP_312895.1 4935554 D 386585 CDS NP_312896.1 15834123 915016 4936717..4939149 1 NC_002695.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4939149 metL 915016 metL Escherichia coli O157:H7 str. Sakai bifunctional aspartate kinase II/homoserine dehydrogenase II NP_312896.1 4936717 D 386585 CDS NP_312897.1 15834124 915018 4939498..4940388 1 NC_002695.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4940388 metF 915018 metF Escherichia coli O157:H7 str. Sakai 5,10-methylenetetrahydrofolate reductase NP_312897.1 4939498 D 386585 CDS NP_312898.1 15834125 915019 4940717..4942897 1 NC_002695.1 similar to KATG_ECOLI gi|1790378 (conserved in Escherichia coli K-12); hydroperoxidase HPI(I) 4942897 915019 ECs4871 Escherichia coli O157:H7 str. Sakai hydroperoxidase HPI(I) NP_312898.1 4940717 D 386585 CDS NP_312899.2 38704214 915008 4942991..4943896 1 NC_002695.1 similar to YIJE_ECOLI gi|1790379 (conserved in Escherichia coli K-12); hypothetical protein 4943896 915008 ECs4872 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312899.2 4942991 D 386585 CDS NP_312900.1 15834127 915009 complement(4943923..4944540) 1 NC_002695.1 similar to YIJF_ECOLI gi|1790380 (conserved in Escherichia coli K-12); hypothetical protein 4944540 915009 ECs4873 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312900.1 4943923 R 386585 CDS NP_312901.2 38704215 915010 complement(4944814..4945917) 1 NC_002695.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4945917 gldA 915010 gldA Escherichia coli O157:H7 str. Sakai glycerol dehydrogenase NP_312901.2 4944814 R 386585 CDS NP_312902.1 15834129 915012 complement(4945928..4946590) 1 NC_002695.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4946590 915012 ECs4875 Escherichia coli O157:H7 str. Sakai fructose-6-phosphate aldolase NP_312902.1 4945928 R 386585 CDS NP_312903.2 38704216 915013 complement(4946602..4949103) 1 NC_002695.1 similar to PTSA_ECOLI gi|1790383 (conserved in Escherichia coli K-12); PEP-protein phosphotransferase system enzyme I 4949103 915013 ECs4877 Escherichia coli O157:H7 str. Sakai PEP-protein phosphotransferase system enzyme I NP_312903.2 4946602 R 386585 CDS NP_312904.1 15834131 915003 4948712..4949203 1 NC_002695.1 similar to YIJI_ECOLI gi|1790384; hypothetical protein 4949203 915003 ECs4876 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312904.1 4948712 D 386585 CDS NP_312906.1 15834133 915006 4950506..4950826 1 NC_002695.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 4950826 915006 ECs4879 Escherichia coli O157:H7 str. Sakai PTS system fructose-like transporter subunit EIIB NP_312906.1 4950506 D 386585 CDS NP_312907.1 15834134 915007 4950877..4953174 1 NC_002695.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4953174 pflD 915007 pflD Escherichia coli O157:H7 str. Sakai formate acetyltransferase 2 NP_312907.1 4950877 D 386585 CDS NP_312908.2 38704217 914995 4953179..4954018 1 NC_002695.1 similar to PFLC_ECOLI gi|1790389 (conserved in Escherichia coli K-12); pyruvate formate lyase II activase 4954018 914995 ECs4881 Escherichia coli O157:H7 str. Sakai pyruvate formate lyase II activase NP_312908.2 4953179 D 386585 CDS NP_312909.1 15834136 914996 4954020..4954361 1 NC_002695.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4954361 914996 ECs4882 Escherichia coli O157:H7 str. Sakai fructose-like phosphotransferase EIIB subunit 3 NP_312909.1 4954020 D 386585 CDS NP_312910.1 15834137 914997 complement(4954348..4955199) 1 NC_002695.1 similar to YIJO_ECOLI gi|1790391 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 4955199 914997 ECs4883 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_312910.1 4954348 R 386585 CDS NP_312911.1 15834138 915000 complement(4955414..4957147) 1 NC_002695.1 similar to YIJP_ECOLI gi|4741821|gb|AAD28716.1|AF112861_1 (conserved in Escherichia coli K-12); hypothetical protein 4957147 915000 ECs4884 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312911.1 4955414 R 386585 CDS NP_312912.1 15834139 915001 complement(4957330..4959981) 1 NC_002695.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4959981 915001 ECs4885 Escherichia coli O157:H7 str. Sakai phosphoenolpyruvate carboxylase NP_312912.1 4957330 R 386585 CDS NP_312913.1 15834140 914989 complement(4960333..4961484) 1 NC_002695.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4961484 914989 ECs4886 Escherichia coli O157:H7 str. Sakai acetylornithine deacetylase NP_312913.1 4960333 R 386585 CDS NP_312914.1 15834141 914990 4961638..4962642 1 NC_002695.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4962642 argC 914990 argC Escherichia coli O157:H7 str. Sakai N-acetyl-gamma-glutamyl-phosphate reductase NP_312914.1 4961638 D 386585 CDS NP_312915.2 162139736 914992 4962653..4963426 1 NC_002695.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4963426 914992 ECs4888 Escherichia coli O157:H7 str. Sakai acetylglutamate kinase NP_312915.2 4962653 D 386585 CDS NP_312916.1 15834143 914993 4963487..4964860 1 NC_002695.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4964860 914993 ECs4889 Escherichia coli O157:H7 str. Sakai argininosuccinate lyase NP_312916.1 4963487 D 386585 CDS NP_312917.1 15834144 914984 4965127..4966044 1 NC_002695.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4966044 914984 ECs4890 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator OxyR NP_312917.1 4965127 D 386585 CDS NP_312918.2 162139735 914986 complement(4966027..4967427) 1 NC_002695.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4967427 914986 ECs4891 Escherichia coli O157:H7 str. Sakai soluble pyridine nucleotide transhydrogenase NP_312918.2 4966027 R 386585 CDS NP_312919.1 15834146 914987 4967757..4968923 1 NC_002695.1 similar to amino acid amidohydrolases e.g. benzoylglycine amidohydrolase (Hippuricase) [Campylobacter jejuni] gi|1170277|spP45493|HIPO_CAMJE; amino acid amidohydrolase 4968923 914987 ECs4892 Escherichia coli O157:H7 str. Sakai amino acid amidohydrolase NP_312919.1 4967757 D 386585 CDS NP_312920.1 15834147 914976 4968966..4970282 1 NC_002695.1 similar to membrane transport proteins e.g. citrate-proton symporter [Klebsiella pneumoniae] gi|116482|sp|P16482|CIT1_KLEPN; membrane transport/symporter protein 4970282 914976 ECs4893 Escherichia coli O157:H7 str. Sakai membrane transport/symporter protein NP_312920.1 4968966 D 386585 CDS NP_312921.1 15834148 914977 4970332..4971036 1 NC_002695.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4971036 914977 ECs4894 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor FabR NP_312921.1 4970332 D 386585 CDS NP_312922.1 15834149 914979 4971036..4971395 1 NC_002695.1 similar to YIJD_ECOLI gi|1790402 (conserved in Escherichia coli K-12); hypothetical protein 4971395 914979 ECs4895 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312922.1 4971036 D 386585 CDS NP_312923.1 15834150 914980 complement(4971435..4972535) 1 NC_002695.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4972535 914980 ECs4896 Escherichia coli O157:H7 str. Sakai tRNA (uracil-5-)-methyltransferase NP_312923.1 4971435 R 386585 CDS NP_312924.1 15834151 914972 4972904..4974748 1 NC_002695.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4974748 btuB 914972 btuB Escherichia coli O157:H7 str. Sakai vitamin B12/cobalamin outer membrane transporter NP_312924.1 4972904 D 386585 CDS NP_312925.2 162139734 914973 4974693..4975550 1 NC_002695.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4975550 914973 ECs4898 Escherichia coli O157:H7 str. Sakai glutamate racemase NP_312925.2 4974693 D 386585 CDS NP_312926.1 15834153 914964 4981074..4982102 1 NC_002695.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4982102 murB 914964 murB Escherichia coli O157:H7 str. Sakai UDP-N-acetylenolpyruvoylglucosamine reductase NP_312926.1 4981074 D 386585 CDS NP_312927.1 15834154 914965 4982099..4983064 1 NC_002695.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4983064 birA 914965 birA Escherichia coli O157:H7 str. Sakai biotin--protein ligase NP_312927.1 4982099 D 386585 CDS NP_312928.1 15834155 914967 complement(4983093..4984043) 1 NC_002695.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4984043 914967 ECs4901 Escherichia coli O157:H7 str. Sakai pantothenate kinase NP_312928.1 4983093 R 386585 CDS NP_312929.1 15834156 914968 complement(4984230..4984385) 1 NC_002695.1 similar to B3975_ECOLI gi|1790411; hypothetical protein 4984385 914968 ECs4902 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312929.1 4984230 R 386585 CDS NP_312930.1 15834157 914959 4984961..4986145 1 NC_002695.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4986145 tuf 914959 tuf Escherichia coli O157:H7 str. Sakai elongation factor Tu NP_312930.1 4984961 D 386585 CDS NP_312931.1 15834158 914948 4986375..4986758 1 NC_002695.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4986758 secE 914948 secE Escherichia coli O157:H7 str. Sakai preprotein translocase subunit SecE NP_312931.1 4986375 D 386585 CDS NP_312932.1 15834159 914947 4986760..4987305 1 NC_002695.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4987305 nusG 914947 nusG Escherichia coli O157:H7 str. Sakai transcription antitermination protein NusG NP_312932.1 4986760 D 386585 CDS NP_312933.1 15834160 914950 4987464..4987892 1 NC_002695.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4987892 rplK 914950 rplK Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L11 NP_312933.1 4987464 D 386585 CDS NP_312934.1 15834161 914949 4987896..4988600 1 NC_002695.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4988600 rplA 914949 rplA Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L1 NP_312934.1 4987896 D 386585 CDS NP_312935.1 15834162 914951 4988892..4989389 1 NC_002695.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4989389 rplJ 914951 rplJ Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L10 NP_312935.1 4988892 D 386585 CDS NP_312936.1 15834163 914954 4989456..4989821 1 NC_002695.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4989821 rplL 914954 rplL Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L7/L12 NP_312936.1 4989456 D 386585 CDS NP_312937.1 15834164 914942 4990141..4994169 1 NC_002695.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4994169 rpoB 914942 rpoB Escherichia coli O157:H7 str. Sakai DNA-directed RNA polymerase subunit beta NP_312937.1 4990141 D 386585 CDS NP_312938.1 15834165 914941 4994246..4998469 1 NC_002695.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4998469 914941 ECs4911 Escherichia coli O157:H7 str. Sakai DNA-directed RNA polymerase subunit beta' NP_312938.1 4994246 D 386585 CDS NP_312939.1 15834166 914944 4998682..4999125 1 NC_002695.1 heat shock protein; similar to HTRC_ECOLI gi|1790422; protein HtrC 4999125 914944 ECs4912 Escherichia coli O157:H7 str. Sakai protein HtrC NP_312939.1 4998682 D 386585 CDS NP_312940.1 15834167 914943 complement(4999560..5000693) 1 NC_002695.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 5000693 thiH 914943 thiH Escherichia coli O157:H7 str. Sakai thiamine biosynthesis protein ThiH NP_312940.1 4999560 R 386585 CDS NP_312941.2 38704218 914945 complement(5000690..5001460) 1 NC_002695.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 5001460 thiG 914945 thiG Escherichia coli O157:H7 str. Sakai thiazole synthase NP_312941.2 5000690 R 386585 CDS NP_944578.1 38704219 2693800 complement(5001462..5001662) 1 NC_002695.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 5001662 2693800 ECs5575 Escherichia coli O157:H7 str. Sakai sulfur carrier protein ThiS NP_944578.1 5001462 R 386585 CDS NP_312942.2 38704220 914934 complement(5001646..5002401) 1 NC_002695.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 5002401 thiF 914934 thiF Escherichia coli O157:H7 str. Sakai thiamine biosynthesis protein ThiF NP_312942.2 5001646 R 386585 CDS NP_312943.1 15834170 914936 complement(5002394..5003029) 1 NC_002695.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 5003029 thiE 914936 thiE Escherichia coli O157:H7 str. Sakai thiamine-phosphate pyrophosphorylase NP_312943.1 5002394 R 386585 CDS NP_312944.1 15834171 914937 complement(5003029..5004924) 1 NC_002695.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 5004924 thiC 914937 thiC Escherichia coli O157:H7 str. Sakai thiamine biosynthesis protein ThiC NP_312944.1 5003029 R 386585 CDS NP_312945.1 15834172 914938 complement(5005157..5005633) 1 NC_002695.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 5005633 914938 ECs4918 Escherichia coli O157:H7 str. Sakai anti-RNA polymerase sigma 70 factor NP_312945.1 5005157 R 386585 CDS NP_312946.1 15834173 914939 5005728..5006501 1 NC_002695.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 5006501 nudC 914939 nudC Escherichia coli O157:H7 str. Sakai NADH pyrophosphatase NP_312946.1 5005728 D 386585 CDS NP_312947.1 15834174 914940 5006541..5007605 1 NC_002695.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 5007605 hemE 914940 hemE Escherichia coli O157:H7 str. Sakai uroporphyrinogen decarboxylase NP_312947.1 5006541 D 386585 CDS NP_312948.1 15834175 914931 5007615..5008286 1 NC_002695.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 5008286 914931 ECs4921 Escherichia coli O157:H7 str. Sakai endonuclease V NP_312948.1 5007615 D 386585 CDS NP_312949.1 15834176 914932 5008329..5008919 1 NC_002695.1 similar to YJAG_ECOLI gi|1790432 (conserved in Escherichia coli K-12); hypothetical protein 5008919 914932 ECs4922 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312949.1 5008329 D 386585 CDS NP_312950.1 15834177 914933 5009106..5009378 1 NC_002695.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 5009378 914933 ECs4923 Escherichia coli O157:H7 str. Sakai transcriptional regulator HU subunit alpha NP_312950.1 5009106 D 386585 CDS NP_312951.1 15834178 914935 5009391..5010086 1 NC_002695.1 similar to YJAH_ECOLI gi|1790434 (conserved in Escherichia coli K-12); hypothetical protein 5010086 914935 ECs4924 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312951.1 5009391 D 386585 CDS NP_312952.2 38704221 915713 complement(5010088..5010513) 1 NC_002695.1 similar to YJAI_ECOLI gi|1790435 (conserved in Escherichia coli K-12); zinc resistance protein 5010513 zraP 915713 zraP Escherichia coli O157:H7 str. Sakai zinc resistance protein NP_312952.2 5010088 R 386585 CDS NP_312953.1 15834180 916224 5010751..5012127 1 NC_002695.1 sensor kinase; similar to HYDH_ECOLI gi|1790436 (conserved in Escherichia coli K-12); sensor protein ZraS 5012127 916224 ECs4926 Escherichia coli O157:H7 str. Sakai sensor protein ZraS NP_312953.1 5010751 D 386585 CDS NP_312954.1 15834181 916250 5012124..5013449 1 NC_002695.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 5013449 916250 ECs4927 Escherichia coli O157:H7 str. Sakai transcriptional regulatory protein ZraR NP_312954.1 5012124 D 386585 CDS NP_312955.1 15834182 914922 complement(5013446..5014735) 1 NC_002695.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 5014735 914922 ECs4928 Escherichia coli O157:H7 str. Sakai phosphoribosylamine--glycine ligase NP_312955.1 5013446 R 386585 CDS NP_312956.1 15834183 914853 complement(5014747..5016336) 1 NC_002695.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 5016336 purH 914853 purH Escherichia coli O157:H7 str. Sakai bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_312956.1 5014747 R 386585 CDS NP_312957.1 15834184 916435 complement(5022080..5022523) 1 NC_002695.1 similar to YJAB_ECOLI gi|1790442 (conserved in Escherichia coli K-12); hypothetical protein 5022523 916435 ECs4930 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312957.1 5022080 R 386585 CDS NP_312958.1 15834185 914846 5022680..5023609 1 NC_002695.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 5023609 914846 ECs4931 Escherichia coli O157:H7 str. Sakai homoserine O-succinyltransferase NP_312958.1 5022680 D 386585 CDS NP_312959.1 15834186 914847 5023878..5025479 1 NC_002695.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 5025479 914847 ECs4932 Escherichia coli O157:H7 str. Sakai malate synthase NP_312959.1 5023878 D 386585 CDS NP_312960.1 15834187 914848 5025509..5026813 1 NC_002695.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 5026813 914848 ECs4933 Escherichia coli O157:H7 str. Sakai isocitrate lyase NP_312960.1 5025509 D 386585 CDS NP_312961.1 15834188 914849 5026997..5028733 1 NC_002695.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 5028733 aceK 914849 aceK Escherichia coli O157:H7 str. Sakai bifunctional isocitrate dehydrogenase kinase/phosphatase NP_312961.1 5026997 D 386585 CDS NP_312962.1 15834189 914850 complement(5028702..5030888) 1 NC_002695.1 similar to ARP_ECOLI gi|1790447 (conserved in Escherichia coli K-12); regulator of acetyl CoA synthetase 5030888 914850 ECs4935 Escherichia coli O157:H7 str. Sakai regulator of acetyl CoA synthetase NP_312962.1 5028702 R 386585 CDS NP_312963.2 162139733 914851 complement(5031205..5032029) 1 NC_002695.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 5032029 914851 ECs4936 Escherichia coli O157:H7 str. Sakai IclR family transcriptional regulator NP_312963.2 5031205 R 386585 CDS NP_312964.1 15834191 914852 5032229..5035912 1 NC_002695.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 5035912 metH 914852 metH Escherichia coli O157:H7 str. Sakai B12-dependent methionine synthase NP_312964.1 5032229 D 386585 CDS NP_312965.1 15834192 914841 5036132..5037763 1 NC_002695.1 similar to YJBB_ECOLI gi|1790451 (conserved in Escherichia coli K-12); hypothetical protein 5037763 914841 ECs4938 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312965.1 5036132 D 386585 CDS NP_312966.1 15834193 914842 complement(5037854..5038543) 1 NC_002695.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 5038543 914842 ECs4939 Escherichia coli O157:H7 str. Sakai peptidase E NP_312966.1 5037854 R 386585 CDS NP_312967.1 15834194 914843 5038651..5038806 1 NC_002695.1 similar to hypothetical protein b3122 [Escherichia coli (strain K-12)] gi|7466507|pir||G65101; hypothetical protein 5038806 914843 ECs4940 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312967.1 5038651 D 386585 CDS NP_312968.1 15834195 914844 complement(5038926..5040155) 1 NC_002695.1 similar to L-sorbose 1-phosphate dehydrogenases, e.g. [Klebsiella pneumoniae] gi|586014|sp|P37084|SORE_KLEPN; L-sorbose 1-phosphate dehydrogenase 5040155 914844 ECs4941 Escherichia coli O157:H7 str. Sakai L-sorbose 1-phosphate dehydrogenase NP_312968.1 5038926 R 386585 CDS NP_312970.1 15834197 914837 complement(5041093..5041623) 1 NC_002695.1 repressor; similar to hypothetical protein HI1476 [Haemophilus influenzae] gi|1175815|sp|P44207|YE76_HAEIN, probable repressor protein [Bacteriophage D1]; regulatory protein 5041623 914837 ECs4943 Escherichia coli O157:H7 str. Sakai regulatory protein NP_312970.1 5041093 R 386585 CDS NP_312971.1 15834198 914838 5041814..5042062 1 NC_002695.1 similar to Ner-like DNA-binding proteins e.g. gi|6900348|emb|CAB71960.1|; DNA-binding protein 5042062 914838 ECs4944 Escherichia coli O157:H7 str. Sakai DNA-binding protein NP_312971.1 5041814 D 386585 CDS NP_312972.1 15834199 914839 5042064..5044154 1 NC_002695.1 similar to transposases e.g. [Neisseria meningitidis] gi|7379960|emb|CAB84536.1|; phage transposase 5044154 914839 ECs4945 Escherichia coli O157:H7 str. Sakai phage transposase NP_312972.1 5042064 D 386585 CDS NP_312973.1 15834200 914840 5044225..5045157 1 NC_002695.1 similar to DNA transposition protein B [Bacteriophage Mu] gi|139318|sp|P03763|VPB_BPMU; DNA transposition protein 5045157 914840 ECs4946 Escherichia coli O157:H7 str. Sakai DNA transposition protein NP_312973.1 5044225 D 386585 CDS NP_312974.1 15834201 914833 5045160..5045381 1 NC_002695.1 similar to phosphoserine phosphatase [Neisseria meningitidis MC58] gi|7226221|gb|AAF41385.1|; hypothetical protein 5045381 914833 ECs4947 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312974.1 5045160 D 386585 CDS NP_312975.1 15834202 914834 5045394..5045648 1 NC_002695.1 hypothetical protein 5045648 914834 ECs4948 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312975.1 5045394 D 386585 CDS NP_312976.1 15834203 914835 5045650..5045931 1 NC_002695.1 hypothetical protein 5045931 914835 ECs4949 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312976.1 5045650 D 386585 CDS NP_312977.1 15834204 914836 5045928..5046200 1 NC_002695.1 hypothetical protein 5046200 914836 ECs4950 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312977.1 5045928 D 386585 CDS NP_312978.1 15834205 914827 5046205..5046498 1 NC_002695.1 hypothetical protein 5046498 914827 ECs4951 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312978.1 5046205 D 386585 CDS NP_312979.1 15834206 914828 5046510..5047040 1 NC_002695.1 similar to host-nuclease inhibitor proteins (Gam) e.g. [Bacteriophage Mu] gi|138127|sp|P06023|VGAM_BPMU; host-nuclease inhibitor protein 5047040 914828 ECs4952 Escherichia coli O157:H7 str. Sakai host-nuclease inhibitor protein NP_312979.1 5046510 D 386585 CDS NP_312980.1 15834207 914830 5047138..5047680 1 NC_002695.1 hypothetical protein 5047680 914830 ECs4953 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312980.1 5047138 D 386585 CDS NP_312981.1 15834208 914831 5047684..5048217 1 NC_002695.1 similar to Gp11 [Bacteriophage Mu] gi|6010385|gb|AAF01088.1|AF083977_7; hypothetical protein 5048217 914831 ECs4954 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312981.1 5047684 D 386585 CDS NP_312982.1 15834209 914832 5048217..5048732 1 NC_002695.1 similar to gp12 [Bacteriophage Mu] gi|215568|gb|AAA32400.1|; hypothetical protein 5048732 914832 ECs4955 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312982.1 5048217 D 386585 CDS NP_312983.1 15834210 914821 5048997..5049287 1 NC_002695.1 similar to gp9 [Bacteriophage Mu] gi|6010430|gb|AAF01133.1|AF083977_54; hypothetical protein 5049287 914821 ECs4956 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312983.1 5048997 D 386585 CDS NP_944579.1 38704222 2693801 5049284..5049469 1 NC_002695.1 hypothetical protein 5049469 2693801 ECs5580 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944579.1 5049284 D 386585 CDS NP_312984.1 15834211 914823 5049466..5049840 1 NC_002695.1 hypothetical protein 5049840 914823 ECs4957 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312984.1 5049466 D 386585 CDS NP_312985.1 15834212 914825 5049833..5050030 1 NC_002695.1 similar to zinc finger proteins e.g. [Rattus norvegicus] gi|141712|sp|P18745|ZO22_XENLA; hypothetical protein 5050030 914825 ECs4958 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312985.1 5049833 D 386585 CDS NP_312986.1 15834213 914826 5050020..5050316 1 NC_002695.1 hypothetical protein 5050316 914826 ECs4959 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312986.1 5050020 D 386585 CDS NP_312987.1 15834214 914329 5050313..5050822 1 NC_002695.1 similar to hypothetical proteins e.g. gp16 [Bacteriophage Mu] gi|6010390|gb|AAF01093.1|AF083977_12; hypothetical protein 5050822 914329 ECs4960 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312987.1 5050313 D 386585 CDS NP_312988.1 15834215 914606 5050892..5051317 1 NC_002695.1 probable positive regulator of late transcription; similar to transcription regulators e.g. positive regulator of late transcription (protein C) [Bacteriophage Mu] gi|139320|sp|P06022|VPC_BPMU; transcriptional regulator 5051317 914606 ECs4961 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_312988.1 5050892 D 386585 CDS NP_312989.1 15834216 914735 5051389..5051889 1 NC_002695.1 endolysin (host cell lysis); similar to endolysins e.g. Lys [Bacteriophage Mu] |126600|sp|P27359|LYCV_BPP21; endolysin 5051889 914735 ECs4962 Escherichia coli O157:H7 str. Sakai endolysin NP_312989.1 5051389 D 386585 CDS NP_312991.1 15834218 914994 5052108..5052554 1 NC_002695.1 similar to P16 [Bacteriophage APSE-1] gi|6118011|gb|AAF03959.1|AF157835_16; hypothetical protein 5052554 914994 ECs4964 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312991.1 5052108 D 386585 CDS NP_312992.1 15834219 914966 5052564..5052791 1 NC_002695.1 similar to traR family, e.g. Orf82 [Bacteriophage P2] gi|732223|sp|Q06424|YO82_BPP2; C4-type zinc finger TraR 5052791 914966 ECs4965 Escherichia coli O157:H7 str. Sakai C4-type zinc finger TraR NP_312992.1 5052564 D 386585 CDS NP_312993.1 15834220 914969 5052772..5053080 1 NC_002695.1 similar to gp25 [Bacteriophage Mu] gi|6010400|gb|AAF01103.1|AF083977_22; hypothetical protein 5053080 914969 ECs4966 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312993.1 5052772 D 386585 CDS NP_312994.1 15834221 914988 5053077..5053367 1 NC_002695.1 similar to hypothetical proteins e.g. gp26 [Bacteriophage Mu] gi|6010401|gb|AAF01104.1|AF083977_23; hypothetical protein 5053367 914988 ECs4967 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312994.1 5053077 D 386585 CDS NP_312995.1 15834222 914975 5053370..5053951 1 NC_002695.1 similar to hypothetical proteins e.g. gp27 [Bacteriophage Mu] gi|6010402|gb|AAF01105.1|AF083977_24; hypothetical protein 5053951 914975 ECs4968 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312995.1 5053370 D 386585 CDS NP_312996.1 15834223 914978 5053951..5055615 1 NC_002695.1 similar to hypothetical proteins e.g. gp28 (possible portal protein H) [Bacteriophage Mu] gi|6010403|gb|AAF01106.1|AF083977_25; portal protein 5055615 914978 ECs4969 Escherichia coli O157:H7 str. Sakai portal protein NP_312996.1 5053951 D 386585 CDS NP_312997.1 15834224 914981 5055678..5057204 1 NC_002695.1 similar to hypothetical proteins e.g. gp29 [Bacteriophage Mu] gi|6010404|gb|AAF01107.1|AF083977_26; hypothetical protein 5057204 914981 ECs4970 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312997.1 5055678 D 386585 CDS NP_312998.1 15834225 914985 5057188..5058513 1 NC_002695.1 similar to hypothetical proteins e.g. gp30 [Bacteriophage Mu] gi|6010405|gb|AAF01108.1|AF083977_27; hypothetical protein 5058513 914985 ECs4971 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_312998.1 5057188 D 386585 CDS NP_312999.1 15834226 914960 5058632..5059105 1 NC_002695.1 similar to G protein [Bacteriophage Mu] gi|267389|sp|Q01261|VPG_BPMU; virion morphogenesis protein 5059105 914960 ECs4972 Escherichia coli O157:H7 str. Sakai virion morphogenesis protein NP_312999.1 5058632 D 386585 CDS NP_313000.1 15834227 914962 5059282..5060406 1 NC_002695.1 similar to gpI [Bacteriophage Mu] gi|7226336|gb|AAF41489.1|; contains potential internal start site for homologue of p20 (Z)- the postulated scaffold protein; protease 5060406 914962 ECs4973 Escherichia coli O157:H7 str. Sakai protease NP_313000.1 5059282 D 386585 CDS NP_313001.1 15834228 914958 5060406..5061353 1 NC_002695.1 similar to protein T [Bacteriophage Mu] gi|6010409|gb|AAF01112.1|AF083977_31, hypothetical proteins e.g. [Neisseria meningitidis] gi|6900377|emb|CAB71989.1|; major head subunit 5061353 914958 ECs4974 Escherichia coli O157:H7 str. Sakai major head subunit NP_313001.1 5060406 D 386585 CDS NP_313002.1 15834229 915717 5061397..5061783 1 NC_002695.1 similar to gp35 [Bacteriophage Mu] gi|6010410|gb|AAF01113.1|AF083977_32; hypothetical protein 5061783 915717 ECs4975 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313002.1 5061397 D 386585 CDS NP_313003.1 15834230 915728 5061780..5062199 1 NC_002695.1 similar to hypothetical proteins e.g. gp36 [Bacteriophage Mu] gi|6010411|gb|AAF01114.1|AF083977_33; hypothetical protein 5062199 915728 ECs4976 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313003.1 5061780 D 386585 CDS NP_313004.1 15834231 914946 5062196..5062756 1 NC_002695.1 similar to hypothetical proteins e.g. gp37 [Bacteriophage Mu] gi|1175870|sp|P44231|YF09_HAEIN; hypothetical protein 5062756 914946 ECs4977 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313004.1 5062196 D 386585 CDS NP_313005.1 15834232 914952 5062757..5063002 1 NC_002695.1 similar to hypothetical proteins e.g. gp38 [Bacteriophage Mu] gi|6010413|gb|AAF01116.1|AF083977_35; hypothetical protein 5063002 914952 ECs4978 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313005.1 5062757 D 386585 CDS NP_313006.1 15834233 914953 5062999..5064501 1 NC_002695.1 similar to sheath protein GpL [Bacteriophage Mu] gi|1834291|dbj|BAA19195.1|, hypothetical proteins e.g. [Haemophilus influenzae Rd] gi|1175872|sp|P44233|YF11_HAEIN; tail sheath protein 5064501 914953 ECs4979 Escherichia coli O157:H7 str. Sakai tail sheath protein NP_313006.1 5062999 D 386585 CDS NP_313007.1 15834234 914998 5064510..5064875 1 NC_002695.1 similar to hypothetical proteins e.g. GpM [Bacteriophage Mu] gi|1834292|dbj|BAA19196.1|; hypothetical protein 5064875 914998 ECs4980 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313007.1 5064510 D 386585 CDS NP_313008.1 15834235 915002 5064890..5065366 1 NC_002695.1 similar to hypothetical proteins e.g. ORF3 [Bacteriophage Mu] gi|1834293|dbj|BAA19197.1|; hypothetical protein 5065366 915002 ECs4981 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313008.1 5064890 D 386585 CDS NP_313009.1 15834236 915014 5065493..5067568 1 NC_002695.1 similar to hypothetical proteins e.g. Gp42 (probable tape measure protein) [Bacteriophage Mu] gi|6010417|gb|AAF01120.1|AF083977_39; tape measure protein 5067568 915014 ECs4982 Escherichia coli O157:H7 str. Sakai tape measure protein NP_313009.1 5065493 D 386585 CDS NP_313010.1 15834237 915011 5067534..5068904 1 NC_002695.1 similar to DNA circulation proteins e.g. protein N? [Bacteriophage Mu] gi|6010418|gb|AAF01121.1|AF083977_40; DNA circulation protein 5068904 915011 ECs4983 Escherichia coli O157:H7 str. Sakai DNA circulation protein NP_313010.1 5067534 D 386585 CDS NP_313011.1 15834238 915017 5068888..5070012 1 NC_002695.1 similar to tail proteins e.g. P protein [Bacteriophage Mu] gi|139353|sp|P08558|VPP_BPMU; tail protein 5070012 915017 ECs4984 Escherichia coli O157:H7 str. Sakai tail protein NP_313011.1 5068888 D 386585 CDS NP_313012.1 15834239 915020 5070002..5070616 1 NC_002695.1 similar to hypothetical proteins e.g. gp45 [Bacteriophage Mu] gi|6010420|gb|AAF01123.1|AF083977_42; may be involved in base plate assemblyy; hypothetical protein 5070616 915020 ECs4985 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313012.1 5070002 D 386585 CDS NP_313013.1 15834240 916542 5070609..5071046 1 NC_002695.1 similar to hypothetical proteins e.g. Gp46 [Bacteriophage Mu] gi|6010421|gb|AAF01124.1|AF083977_43; hypothetical protein 5071046 916542 ECs4986 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313013.1 5070609 D 386585 CDS NP_313014.1 15834241 916556 5071043..5072128 1 NC_002695.1 similar to hypothetical proteins e.g. Gp47 [Bacteriophage Mu] gi|6010422|gb|AAF01125.1|AF083977_44; hypothetical protein 5072128 916556 ECs4987 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313014.1 5071043 D 386585 CDS NP_313015.1 15834242 916560 5072119..5072679 1 NC_002695.1 similar to hypothetical proteins e.g. Gp48 [Bacteriophage Mu] gi|6010423|gb|AAF01126.1|AF083977_45; hypothetical protein 5072679 916560 ECs4988 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313015.1 5072119 D 386585 CDS NP_313016.1 15834243 916096 5072679..5073590 1 NC_002695.1 similar to S protein [Bacteriophage Mu] gi|6010424|gb|AAF01127.1|AF083977_46, hypothetical proteins e.g. Bcv [Shigella boydii] gi|96900|pir||A42463; tail fiber 5073590 916096 ECs4989 Escherichia coli O157:H7 str. Sakai tail fiber NP_313016.1 5072679 D 386585 CDS NP_313017.1 15834244 916086 complement(5073625..5074146) 1 NC_002695.1 similar to [Bacteriophage 186] gi|3522882|gb|AAC34165.1|, tail fiber assembly proteins e.g. U protein [Bacteriophage Mu] gi|6010425|gb|AAF01128.1; tail fiber assembly protein 5074146 916086 ECs4990 Escherichia coli O157:H7 str. Sakai tail fiber assembly protein NP_313017.1 5073625 R 386585 CDS NP_313018.1 15834245 914360 complement(5074226..5074429) 1 NC_002695.1 similar to carboxyl terminal part of tail fiber proteins e.g. S [Bacteriophage Mu] gi|6010424|gb|AAF01127.1|AF083977_46; tail fiber protein 5074429 914360 ECs4991 Escherichia coli O157:H7 str. Sakai tail fiber protein NP_313018.1 5074226 R 386585 CDS NP_313019.1 15834246 914359 5074651..5075211 1 NC_002695.1 similar to site-specific recombinases e.g. DNA-invertase Gin [Bacteriophage Mu] gi|6010426|gb|AAF01129.1|AF083977_50; DNA-invertase 5075211 914359 ECs4992 Escherichia coli O157:H7 str. Sakai DNA-invertase NP_313019.1 5074651 D 386585 CDS NP_313020.1 15834247 914356 5075311..5077350 1 NC_002695.1 similar to hypothetical proteins e.g. L0105 [Bacteriophage 933W] gi|4585419|gb|AAD25447.1|AF125520_42; hypothetical protein 5077350 914356 ECs4993 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313020.1 5075311 D 386585 CDS NP_313021.1 15834248 915036 5077497..5077679 1 NC_002695.1 similar to orf25 [Bacteriophage 933W] gi|4499806|emb|CAB39305.1|; hypothetical protein 5077679 915036 ECs4994 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313021.1 5077497 D 386585 CDS NP_313022.1 15834249 915042 5077715..5077960 1 NC_002695.1 similar to hypothetical proteins e.g. L0106 [Bacteriophage 933W] gi|4585420|gb|AAD25448.1|AF125520_43; hypothetical protein 5077960 915042 ECs4995 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313022.1 5077715 D 386585 CDS NP_313023.1 15834250 914351 complement(5077999..5078310) 1 NC_002695.1 hypothetical protein 5078310 914351 ECs4996 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313023.1 5077999 R 386585 CDS NP_313024.1 15834251 916446 5078578..5078778 1 NC_002695.1 similar to translational regulators e.g. Com protein (translational regulator of Mom) [Bacteriophage Mu] gi|7388376|sp|Q53979|VCOM_SHIDY; translational regulator 5078778 916446 ECs4997 Escherichia coli O157:H7 str. Sakai translational regulator NP_313024.1 5078578 D 386585 CDS NP_944580.1 38704223 2693779 complement(5078681..5078917) 1 NC_002695.1 hypothetical protein 5078917 2693779 ECs5581 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944580.1 5078681 R 386585 CDS NP_313025.1 15834252 916307 5078732..5079469 1 NC_002695.1 similar to DNA modification proteins e.g. Mom protein [Bacteriophage Mu] gi|138782|sp|P06018|VMOM_BPMU; DNA modification protein 5079469 916307 ECs4998 Escherichia coli O157:H7 str. Sakai DNA modification protein NP_313025.1 5078732 D 386585 CDS NP_313027.1 15834254 914348 complement(5079801..5080598) 1 NC_002695.1 similar to sorbose-permease IIC components e.g. [Klebsiella pneumoniae] gi|548633|sp|P37082|PTRC_KLEPN; sorbose-permease PTS system IIC component 5080598 914348 ECs5000 Escherichia coli O157:H7 str. Sakai sorbose-permease PTS system IIC component NP_313027.1 5079801 R 386585 CDS NP_313028.1 15834255 914345 complement(5080664..5081158) 1 NC_002695.1 similar to sorbose-permease IIB components e.g. [Klebsiella pneumoniae] gi|1142714|gb|AAB04152.1|; sorbose-permease PTS system IIB component 5081158 914345 ECs5001 Escherichia coli O157:H7 str. Sakai sorbose-permease PTS system IIB component NP_313028.1 5080664 R 386585 CDS NP_313029.1 15834256 915026 complement(5081158..5081565) 1 NC_002695.1 similar to sorbose-permease IIA components, e.g. [Klebsiella pneumoniae] gi|548631|sp|P37080|PTRA_KLEPN; sorbose-permease PTS system IIA component 5081565 915026 ECs5002 Escherichia coli O157:H7 str. Sakai sorbose-permease PTS system IIA component NP_313029.1 5081158 R 386585 CDS NP_313030.1 15834257 914342 complement(5081575..5082381) 1 NC_002695.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 5082381 914342 ECs5003 Escherichia coli O157:H7 str. Sakai sorbitol-6-phosphate 2-dehydrogenase NP_313030.1 5081575 R 386585 CDS NP_313031.2 38704224 914341 complement(5082451..5083419) 1 NC_002695.1 similar to sor-operon regulators (SorC family) [Klebsiella pneumoniae] gi|548950|sp|P37078|SORC_KLEPN; sor-operon regulator 5083419 914341 ECs5004 Escherichia coli O157:H7 str. Sakai sor-operon regulator NP_313031.2 5082451 R 386585 CDS NP_313032.1 15834259 914336 5083746..5084618 1 NC_002695.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 5084618 914336 ECs5005 Escherichia coli O157:H7 str. Sakai 23S rRNA pseudouridine synthase F NP_313032.1 5083746 D 386585 CDS NP_313033.1 15834260 914332 complement(5084619..5084891) 1 NC_002695.1 similar to YJBD_ECOLI gi|1790454 (conserved in Escherichia coli K-12); hypothetical protein 5084891 914332 ECs5006 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313033.1 5084619 R 386585 CDS NP_313034.1 15834261 914331 complement(5085144..5086493) 1 NC_002695.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 5086493 914331 ECs5007 Escherichia coli O157:H7 str. Sakai aspartate kinase NP_313034.1 5085144 R 386585 CDS NP_313035.1 15834262 914328 5087018..5088667 1 NC_002695.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 5088667 pgi 914328 pgi Escherichia coli O157:H7 str. Sakai glucose-6-phosphate isomerase NP_313035.1 5087018 D 386585 CDS NP_313036.1 15834263 914327 5089180..5089422 1 NC_002695.1 similar to YJBE_ECOLI gi|1790458 (conserved in Escherichia coli K-12); hypothetical protein 5089422 914327 ECs5009 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313036.1 5089180 D 386585 CDS NP_313037.2 38704225 914326 5089536..5090174 1 NC_002695.1 similar to YJBF_ECOLI gi|1790459 (conserved in Escherichia coli K-12); hypothetical protein 5090174 914326 ECs5010 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313037.2 5089536 D 386585 CDS NP_313038.1 15834265 914325 5090171..5090908 1 NC_002695.1 similar to YJBG_ECOLI gi|1790460 (conserved in Escherichia coli K-12); hypothetical protein 5090908 914325 ECs5011 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313038.1 5090171 D 386585 CDS NP_313039.1 15834266 914323 5090908..5093004 1 NC_002695.1 similar to YJBH_ECOLI gi|1790461 (conserved in Escherichia coli K-12); hypothetical protein 5093004 914323 ECs5012 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313039.1 5090908 D 386585 CDS NP_313040.1 15834267 914322 5093599..5094009 1 NC_002695.1 similar to YJBA_ECOLI gi|1790462 (conserved in Escherichia coli K-12); phosphate-starvation-inducible protein PsiE 5094009 914322 ECs5013 Escherichia coli O157:H7 str. Sakai phosphate-starvation-inducible protein PsiE NP_313040.1 5093599 D 386585 CDS NP_313041.1 15834268 914320 complement(5094053..5095528) 1 NC_002695.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 5095528 xylE 914320 xylE Escherichia coli O157:H7 str. Sakai D-xylose transporter XylE NP_313041.1 5094053 R 386585 CDS NP_313042.1 15834269 914319 complement(5095900..5096790) 1 NC_002695.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 5096790 malG 914319 malG Escherichia coli O157:H7 str. Sakai maltose transporter permease NP_313042.1 5095900 R 386585 CDS NP_313043.1 15834270 914318 complement(5096805..5098349) 1 NC_002695.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 5098349 malF 914318 malF Escherichia coli O157:H7 str. Sakai maltose transporter membrane protein NP_313043.1 5096805 R 386585 CDS NP_313044.1 15834271 914317 complement(5098503..5099693) 1 NC_002695.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 5099693 malE 914317 malE Escherichia coli O157:H7 str. Sakai maltose ABC transporter periplasmic protein NP_313044.1 5098503 R 386585 CDS NP_313045.1 15834272 914316 5100058..5101173 1 NC_002695.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 5101173 914316 ECs5018 Escherichia coli O157:H7 str. Sakai maltose/maltodextrin transporter ATP-binding protein NP_313045.1 5100058 D 386585 CDS NP_313046.1 15834273 914315 5101245..5102585 1 NC_002695.1 porin involved in the transport of maltose and maltodextrins; maltoporin 5102585 lamB 914315 lamB Escherichia coli O157:H7 str. Sakai maltoporin NP_313046.1 5101245 D 386585 CDS NP_313047.1 15834274 914314 5102736..5103656 1 NC_002695.1 similar to MALM_ECOLI gi|1790470 (conserved in Escherichia coli K-12); maltose regulon periplasmic protein 5103656 914314 ECs5020 Escherichia coli O157:H7 str. Sakai maltose regulon periplasmic protein NP_313047.1 5102736 D 386585 CDS NP_313048.1 15834275 914313 5103885..5105465 1 NC_002695.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 5105465 914313 ECs5021 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313048.1 5103885 D 386585 CDS NP_313049.2 38704226 914312 5105688..5106185 1 NC_002695.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 5106185 ubiC 914312 ubiC Escherichia coli O157:H7 str. Sakai chorismate pyruvate lyase NP_313049.2 5105688 D 386585 CDS NP_313050.1 15834277 915051 5106198..5107070 1 NC_002695.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 5107070 ubiA 915051 ubiA Escherichia coli O157:H7 str. Sakai 4-hydroxybenzoate octaprenyltransferase NP_313050.1 5106198 D 386585 CDS NP_313051.2 162139732 915055 complement(5107225..5109648) 1 NC_002695.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 5109648 915055 ECs5024 Escherichia coli O157:H7 str. Sakai glycerol-3-phosphate acyltransferase NP_313051.2 5107225 R 386585 CDS NP_313052.1 15834279 914310 5109819..5110187 1 NC_002695.1 similar to DGKA_ECOLI gi|1790475 (conserved in Escherichia coli K-12); diacylglycerol kinase 5110187 914310 ECs5025 Escherichia coli O157:H7 str. Sakai diacylglycerol kinase NP_313052.1 5109819 D 386585 CDS NP_313053.1 15834280 914309 5110297..5110905 1 NC_002695.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 5110905 914309 ECs5026 Escherichia coli O157:H7 str. Sakai LexA repressor NP_313053.1 5110297 D 386585 CDS NP_313054.2 162139731 914308 5110978..5112303 1 NC_002695.1 similar to DINF_ECOLI gi|1790477 (conserved in Escherichia coli K-12); DNA-damage-inducible SOS response protein 5112303 914308 ECs5027 Escherichia coli O157:H7 str. Sakai DNA-damage-inducible SOS response protein NP_313054.2 5110978 D 386585 CDS NP_313055.1 15834282 914307 5112419..5112628 1 NC_002695.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 5112628 914307 ECs5028 Escherichia coli O157:H7 str. Sakai stress-response protein NP_313055.1 5112419 D 386585 CDS NP_313056.2 38704227 914306 complement(5112670..5113185) 1 NC_002695.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 5113185 914306 ECs5029 Escherichia coli O157:H7 str. Sakai zinc uptake transcriptional repressor NP_313056.2 5112670 R 386585 CDS NP_313057.1 15834284 914305 5113504..5114400 1 NC_002695.1 similar to YJBL_ECOLI gi|1790481, YJBM_ECOLI gi|1790482; hypothetical protein 5114400 914305 ECs5030 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313057.1 5113504 D 386585 CDS NP_313058.1 15834285 914304 5114823..5115860 1 NC_002695.1 similar to YJBN_ECOLI gi|1790483 (conserved in Escherichia coli K-12); tRNA-dihydrouridine synthase A 5115860 914304 ECs5031 Escherichia coli O157:H7 str. Sakai tRNA-dihydrouridine synthase A NP_313058.1 5114823 D 386585 CDS NP_313059.2 38704228 914303 5115994..5116236 1 NC_002695.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 5116236 pspG 914303 pspG Escherichia coli O157:H7 str. Sakai phage shock protein G NP_313059.2 5115994 D 386585 CDS NP_313060.1 15834287 914302 complement(5116402..5117385) 1 NC_002695.1 similar to QOR_ECOLI gi|1790485 (conserved in Escherichia coli K-12); quinone oxidoreductase 5117385 914302 ECs5033 Escherichia coli O157:H7 str. Sakai quinone oxidoreductase NP_313060.1 5116402 R 386585 CDS NP_313061.1 15834288 914301 5117468..5118883 1 NC_002695.1 unwinds double stranded DNA; replicative DNA helicase 5118883 914301 ECs5034 Escherichia coli O157:H7 str. Sakai replicative DNA helicase NP_313061.1 5117468 D 386585 CDS NP_313062.1 15834289 914300 5118936..5120015 1 NC_002695.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 5120015 alr 914300 alr Escherichia coli O157:H7 str. Sakai alanine racemase NP_313062.1 5118936 D 386585 CDS NP_313063.1 15834290 914299 5120268..5121461 1 NC_002695.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 5121461 914299 ECs5036 Escherichia coli O157:H7 str. Sakai aromatic amino acid aminotransferase NP_313063.1 5120268 D 386585 CDS NP_944581.1 38704229 2693780 complement(5121800..5122198) 1 NC_002695.1 hypothetical protein 5122198 2693780 ECs5582 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944581.1 5121800 R 386585 CDS NP_313064.1 15834291 914298 5122560..5123273 1 NC_002695.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 5123273 aphA 914298 aphA Escherichia coli O157:H7 str. Sakai acid phosphatase/phosphotransferase NP_313064.1 5122560 D 386585 CDS NP_313065.1 15834292 914297 5123384..5123800 1 NC_002695.1 similar to YJBQ_ECOLI gi|1790491 (conserved in Escherichia coli K-12); hypothetical protein 5123800 914297 ECs5038 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313065.1 5123384 D 386585 CDS NP_313066.1 15834293 914296 5123804..5124160 1 NC_002695.1 similar to YJBR_ECOLI gi|2367342 (conserved in Escherichia coli K-12); hypothetical protein 5124160 914296 ECs5039 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313066.1 5123804 D 386585 CDS NP_313067.1 15834294 914295 complement(5124195..5127017) 1 NC_002695.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 5127017 uvrA 914295 uvrA Escherichia coli O157:H7 str. Sakai excinuclease ABC subunit A NP_313067.1 5124195 R 386585 CDS NP_313068.1 15834295 914294 5127272..5127808 1 NC_002695.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 5127808 914294 ECs5041 Escherichia coli O157:H7 str. Sakai single-stranded DNA-binding protein NP_313068.1 5127272 D 386585 CDS NP_313069.2 38704230 916230 complement(5127907..5128188) 1 NC_002695.1 similar to YJCB_ECOLI gi|1790495 (conserved in Escherichia coli K-12); hypothetical protein 5128188 916230 ECs5042 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313069.2 5127907 R 386585 CDS NP_313070.1 15834297 916287 5128617..5130203 1 NC_002695.1 similar to YJCC_ECOLI gi|1790496 (conserved in Escherichia coli K-12); hypothetical protein 5130203 916287 ECs5043 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313070.1 5128617 D 386585 CDS NP_313071.1 15834298 914293 complement(5130206..5130529) 1 NC_002695.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 5130529 914293 ECs5044 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator SoxS NP_313071.1 5130206 R 386585 CDS NP_313072.1 15834299 914292 5130615..5131079 1 NC_002695.1 similar to SOXR_ECOLI gi|1790498 (conserved in Escherichia coli K-12); redox-sensitive transcriptional activator SoxR 5131079 914292 ECs5045 Escherichia coli O157:H7 str. Sakai redox-sensitive transcriptional activator SoxR NP_313072.1 5130615 D 386585 CDS NP_313073.1 15834300 914291 5131625..5132974 1 NC_002695.1 similar to YJCD_ECOLI gi|1790499 (conserved in Escherichia coli K-12); hypothetical protein 5132974 914291 ECs5046 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313073.1 5131625 D 386585 CDS NP_313074.1 15834301 914279 5133125..5134774 1 NC_002695.1 similar to YJCE_ECOLI gi|1790501 (conserved in Escherichia coli K-12); hypothetical protein 5134774 914279 ECs5047 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313074.1 5133125 D 386585 CDS NP_313075.1 15834302 914280 complement(5134928..5136220) 1 NC_002695.1 similar to YJCF_ECOLI gi|1790502 (conserved in Escherichia coli K-12); hypothetical protein 5136220 914280 ECs5048 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313075.1 5134928 R 386585 CDS NP_313076.1 15834303 914281 complement(5136401..5138050) 1 NC_002695.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 5138050 actP 914281 actP Escherichia coli O157:H7 str. Sakai acetate permease NP_313076.1 5136401 R 386585 CDS NP_313077.1 15834304 914283 complement(5138047..5138361) 1 NC_002695.1 similar to YJCH_ECOLI gi|1790504 (conserved in Escherichia coli K-12); hypothetical protein 5138361 914283 ECs5050 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313077.1 5138047 R 386585 CDS NP_313078.1 15834305 914284 complement(5138562..5140520) 1 NC_002695.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 5140520 914284 ECs5051 Escherichia coli O157:H7 str. Sakai acetyl-CoA synthetase NP_313078.1 5138562 R 386585 CDS NP_313079.1 15834306 914290 5140913..5142349 1 NC_002695.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 5142349 nrfA 914290 nrfA Escherichia coli O157:H7 str. Sakai cytochrome c552 NP_313079.1 5140913 D 386585 CDS NP_313080.1 15834307 914289 5142388..5142960 1 NC_002695.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 5142960 914289 ECs5053 Escherichia coli O157:H7 str. Sakai cytochrome c nitrite reductase pentaheme subunit NP_313080.1 5142388 D 386585 CDS NP_313081.1 15834308 914288 5142957..5143628 1 NC_002695.1 similar to NRFC_ECOLI gi|2367345 (conserved in Escherichia coli K-12); formate-dependent nitrite reductase; NrfC 5143628 914288 ECs5054 Escherichia coli O157:H7 str. Sakai NrfC NP_313081.1 5142957 D 386585 CDS NP_313082.1 15834309 914287 5143625..5144581 1 NC_002695.1 similar to NRFD_ECOLI gi|1790509 (conserved in Escherichia coli K-12); hypothetical protein 5144581 914287 ECs5055 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313082.1 5143625 D 386585 CDS NP_313083.1 15834310 914286 5144661..5146319 1 NC_002695.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 5146319 914286 ECs5056 Escherichia coli O157:H7 str. Sakai heme lyase subunit NrfE NP_313083.1 5144661 D 386585 CDS NP_313084.1 15834311 914285 5146312..5146695 1 NC_002695.1 similar to NRFF_ECOLI gi|1790512 (conserved in Escherichia coli K-12); formate-dependent nitrite reductase complex subunit NrfF 5146695 914285 ECs5057 Escherichia coli O157:H7 str. Sakai formate-dependent nitrite reductase complex subunit NrfF NP_313084.1 5146312 D 386585 CDS NP_313085.1 15834312 914282 5146692..5147288 1 NC_002695.1 component of formate-dependent nitrite reductase complex; similar to NRFG_ECOLI gi|1790513 (conserved in Escherichia coli K-12); formate-dependent nitrite reductase complex subunit NrfG 5147288 914282 ECs5058 Escherichia coli O157:H7 str. Sakai formate-dependent nitrite reductase complex subunit NrfG NP_313085.1 5146692 D 386585 CDS NP_313086.1 15834313 914266 5147630..5148943 1 NC_002695.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 5148943 gltP 914266 gltP Escherichia coli O157:H7 str. Sakai glutamate/aspartate:proton symporter NP_313086.1 5147630 D 386585 CDS NP_313087.1 15834314 914267 complement(5149121..5149810) 1 NC_002695.1 similar to YJCO_ECOLI gi|1790515 (conserved in Escherichia coli K-12); hypothetical protein 5149810 914267 ECs5060 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313087.1 5149121 R 386585 CDS NP_313088.1 15834315 914271 complement(5149904..5152051) 1 NC_002695.1 similar to FDHF_ECOLI gi|3868721 (conserved in Escherichia coli K-12); selenopolypeptide subunit of formate dehydrogenase H 5152051 914271 ECs5061 Escherichia coli O157:H7 str. Sakai selenopolypeptide subunit of formate dehydrogenase H NP_313088.1 5149904 R 386585 CDS NP_313089.1 15834316 914272 complement(5152249..5153715) 1 NC_002695.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 5153715 914272 ECs5062 Escherichia coli O157:H7 str. Sakai outer membrane efflux protein MdtP NP_313089.1 5152249 R 386585 CDS NP_313090.2 38704231 914278 complement(5153712..5155763) 1 NC_002695.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 5155763 914278 ECs5063 Escherichia coli O157:H7 str. Sakai multidrug efflux system protein MdtO NP_313090.2 5153712 R 386585 CDS NP_313091.1 15834318 914275 complement(5155763..5156794) 1 NC_002695.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 5156794 914275 ECs5064 Escherichia coli O157:H7 str. Sakai multidrug resistance protein MdtN NP_313091.1 5155763 R 386585 CDS NP_313092.1 15834319 916213 complement(5156813..5157088) 1 NC_002695.1 hypothetical protein 5157088 916213 ECs5065 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313092.1 5156813 R 386585 CDS NP_313093.1 15834320 914274 complement(5157297..5159294) 1 NC_002695.1 similar to YJCS_ECOLI gi|2367350 (conserved in Escherichia coli K-12); hypothetical protein 5159294 914274 ECs5066 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313093.1 5157297 R 386585 CDS NP_313094.1 15834321 914270 5159573..5160280 1 NC_002695.1 similar to regulatory proteins e.g. aerobic respiration control protein [Zymomonas mobilis] gi|4511977|gb|AAD21537.1|; regulatory protein 5160280 914270 ECs5067 Escherichia coli O157:H7 str. Sakai regulatory protein NP_313094.1 5159573 D 386585 CDS NP_313095.1 15834322 914268 complement(5160277..5161278) 1 NC_002695.1 similar to sugar kinases e.g. fructokinase homolog ydjE [Bacillus subtilis] gi|3915420|sp|O34768|YDJE_BACSU; sugar kinase 5161278 914268 ECs5068 Escherichia coli O157:H7 str. Sakai sugar kinase NP_313095.1 5160277 R 386585 CDS NP_313096.1 15834323 914259 complement(5161275..5162135) 1 NC_002695.1 similar to aldolases e.g. fructose-bisphosphate aldolase (EC 4.1.2.13) FbaA [Bacillus subtilis] gi|543796|sp|P13243|ALF1_BACSU; hypothetical protein 5162135 914259 ECs5069 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313096.1 5161275 R 386585 CDS NP_313097.1 15834324 914261 complement(5162150..5162833) 1 NC_002695.1 similar to hypothetical protein ydaE [Bacillus subtilis] gi|7474928|pir||E69768; hypothetical protein 5162833 914261 ECs5070 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313097.1 5162150 R 386585 CDS NP_313098.1 15834325 914260 complement(5162888..5163829) 1 NC_002695.1 similar to carbohydrate binding protein, C-terminal part of bifunctional carbohydrate binding and transport protein Streptomyces coelicolor A3(2) CAB66286; carbohydrate binding protein 5163829 914260 ECs5071 Escherichia coli O157:H7 str. Sakai carbohydrate binding protein NP_313098.1 5162888 R 386585 CDS NP_313099.1 15834326 914263 complement(5163848..5164822) 1 NC_002695.1 similar to carbohydrate ABC transporters (permease) e.g. ribose ABC transporter (permease) rbsC [Bacillus subtilis] gi|7446897|pir||B69690; carbohydrate ABC transporter permease 5164822 914263 ECs5072 Escherichia coli O157:H7 str. Sakai carbohydrate ABC transporter permease NP_313099.1 5163848 R 386585 CDS NP_313100.1 15834327 914265 complement(5164819..5166339) 1 NC_002695.1 similar to sugar ABC transporter, ATP-binding proteins e.g. ribose ABC transporter (ATP-binding protein) rbsA [Bacillus subtilis] gi|7404442|sp|P36947|RBSA_BACSU; sugar ABC transporter ATP-binding protein 5166339 914265 ECs5073 Escherichia coli O157:H7 str. Sakai sugar ABC transporter ATP-binding protein NP_313100.1 5164819 R 386585 CDS NP_313101.1 15834328 914264 5166453..5168723 1 NC_002695.1 similar to histidine protein kinases e.g. histidine protein kinase-response regulator hybrid protein CvgSY [Pseudomonas syringae pv. syringae] gi|5019771|gb|AAD37857.1|AF133263_2; histidine protein kinase 5168723 914264 ECs5074 Escherichia coli O157:H7 str. Sakai histidine protein kinase NP_313101.1 5166453 D 386585 CDS NP_944582.1 38704232 2693816 5168792..5169121 1 NC_002695.1 hypothetical protein 5169121 2693816 ECs5584 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944582.1 5168792 D 386585 CDS NP_313102.1 15834329 912306 complement(5169198..5169956) 1 NC_002695.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 5169956 phnP 912306 phnP Escherichia coli O157:H7 str. Sakai carbon-phosphorus lyase complex accessory protein NP_313102.1 5169198 R 386585 CDS NP_313103.1 15834330 916349 complement(5169958..5170383) 1 NC_002695.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 5170383 916349 ECs5076 Escherichia coli O157:H7 str. Sakai aminoalkylphosphonic acid N-acetyltransferase NP_313103.1 5169958 R 386585 CDS NP_313104.1 15834331 914257 complement(5170380..5170937) 1 NC_002695.1 similar to PHNN_ECOLI gi|1790532 (conserved in Escherichia coli K-12); ribose 1,5-bisphosphokinase 5170937 914257 ECs5077 Escherichia coli O157:H7 str. Sakai ribose 1,5-bisphosphokinase NP_313104.1 5170380 R 386585 CDS NP_313105.1 15834332 916538 complement(5170937..5172073) 1 NC_002695.1 similar to PHNM_ECOLI gi|1790533 (conserved in Escherichia coli K-12); protein PhnM 5172073 916538 ECs5078 Escherichia coli O157:H7 str. Sakai protein PhnM NP_313105.1 5170937 R 386585 CDS NP_313106.1 15834333 916548 complement(5172070..5172750) 1 NC_002695.1 similar to PHNL_ECOLI gi|1790534 (conserved in Escherichia coli K-12); phosphonate ABC transporter ATP-binding protein 5172750 916548 ECs5079 Escherichia coli O157:H7 str. Sakai phosphonate ABC transporter ATP-binding protein NP_313106.1 5172070 R 386585 CDS NP_313107.1 15834334 914255 complement(5172861..5173619) 1 NC_002695.1 similar to PHNK_ECOLI gi|1790535 (conserved in Escherichia coli K-12); phosphonate C-P lyase system protein PhnK 5173619 phnK 914255 phnK Escherichia coli O157:H7 str. Sakai phosphonate C-P lyase system protein PhnK NP_313107.1 5172861 R 386585 CDS NP_313108.1 15834335 914256 complement(5173616..5174461) 1 NC_002695.1 similar to PHNJ_ECOLI gi|1790536 (conserved in Escherichia coli K-12); protein PhnJ 5174461 914256 ECs5081 Escherichia coli O157:H7 str. Sakai protein PhnJ NP_313108.1 5173616 R 386585 CDS NP_313109.1 15834336 914254 complement(5174454..5175518) 1 NC_002695.1 similar to PHNI_ECOLI gi|1790537 (conserved in Escherichia coli K-12); protein PhnI 5175518 914254 ECs5082 Escherichia coli O157:H7 str. Sakai protein PhnI NP_313109.1 5174454 R 386585 CDS NP_313110.1 15834337 914253 complement(5175518..5176102) 1 NC_002695.1 similar to PHNH_ECOLI gi|1790538 (conserved in Escherichia coli K-12); carbon-phosphorus lyase complex subunit 5176102 phnH 914253 phnH Escherichia coli O157:H7 str. Sakai carbon-phosphorus lyase complex subunit NP_313110.1 5175518 R 386585 CDS NP_313111.1 15834338 914252 complement(5176099..5176551) 1 NC_002695.1 similar to PHNG_ECOLI gi|1790539 (conserved in Escherichia coli K-12); protein PhnG 5176551 914252 ECs5084 Escherichia coli O157:H7 str. Sakai protein PhnG NP_313111.1 5176099 R 386585 CDS NP_313112.1 15834339 914249 complement(5176552..5177277) 1 NC_002695.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 5177277 914249 ECs5085 Escherichia coli O157:H7 str. Sakai phosphonate metabolism transcriptional regulator PhnF NP_313112.1 5176552 R 386585 CDS NP_313113.1 15834340 914246 complement(5177298..5178128) 1 NC_002695.1 similar to PHNE_ECOLI (Strain B) SW: P16683, PHNE_ECOLI (strain K-12) gi|1790542, b4103_ECOLI (strain K-12) gi|179054; membrane channel protein component of Pn transporter 5178128 914246 ECs5086 Escherichia coli O157:H7 str. Sakai membrane channel protein component of Pn transporter NP_313113.1 5177298 R 386585 CDS NP_313114.1 15834341 914245 complement(5178183..5179199) 1 NC_002695.1 similar to PHND_ECOLI gi|1790543 (conserved in Escherichia coli K-12); periplasmic binding protein component of Pn transporter 5179199 914245 ECs5087 Escherichia coli O157:H7 str. Sakai periplasmic binding protein component of Pn transporter NP_313114.1 5178183 R 386585 CDS NP_313115.1 15834342 914244 complement(5179224..5180012) 1 NC_002695.1 similar to PHNC_ECOLI gi|1790544 (conserved in Escherichia coli K-12); phosphonate/organophosphate ester transporter subunit 5180012 914244 ECs5088 Escherichia coli O157:H7 str. Sakai phosphonate/organophosphate ester transporter subunit NP_313115.1 5179224 R 386585 CDS NP_313116.1 15834343 914243 complement(5180145..5180588) 1 NC_002695.1 similar to PHNB_ECOLI gi|1790546 (conserved in Escherichia coli K-12); hypothetical protein 5180588 914243 ECs5089 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313116.1 5180145 R 386585 CDS NP_313117.1 15834344 914242 complement(5180847..5181182) 1 NC_002695.1 similar to PHNA_ECOLI gi|1790547 (conserved in Escherichia coli K-12); hypothetical protein 5181182 914242 ECs5090 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313117.1 5180847 R 386585 CDS NP_313118.1 15834345 914241 5181584..5183812 1 NC_002695.1 similar to YJDA_ECOLI gi|1790548 (conserved in Escherichia coli K-12); hypothetical protein 5183812 914241 ECs5091 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313118.1 5181584 D 386585 CDS NP_313119.2 38704233 914240 5183809..5184687 1 NC_002695.1 similar to YJCZ_ECOLI gi|1790549 (conserved in Escherichia coli K-12); hypothetical protein 5184687 914240 ECs5092 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313119.2 5183809 D 386585 CDS NP_313120.1 15834347 914238 5184951..5186453 1 NC_002695.1 similar to PROP_ECOLI gi|1790550 (conserved in Escherichia coli K-12); proline/glycine betaine transporter 5186453 914238 ECs5093 Escherichia coli O157:H7 str. Sakai proline/glycine betaine transporter NP_313120.1 5184951 D 386585 CDS NP_313121.1 15834348 914237 complement(5186630..5187721) 1 NC_002695.1 similar to BASS_ECOLI gi|1790551 (conserved in Escherichia coli K-12); sensor protein BasS/PmrB 5187721 914237 ECs5094 Escherichia coli O157:H7 str. Sakai sensor protein BasS/PmrB NP_313121.1 5186630 R 386585 CDS NP_313122.1 15834349 913995 complement(5187731..5188399) 1 NC_002695.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 5188399 913995 ECs5095 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator BasR NP_313122.1 5187731 R 386585 CDS NP_313123.1 15834350 914018 complement(5188396..5190069) 1 NC_002695.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 5190069 914018 ECs5096 Escherichia coli O157:H7 str. Sakai cell division protein NP_313123.1 5188396 R 386585 CDS NP_313124.1 15834351 914204 complement(5190143..5191480) 1 NC_002695.1 similar to YJDE_ECOLI gi|2367353 (conserved in Escherichia coli K-12); arginine:agmatin antiporter 5191480 914204 ECs5097 Escherichia coli O157:H7 str. Sakai arginine:agmatin antiporter NP_313124.1 5190143 R 386585 CDS NP_313125.1 15834352 914236 complement(5191617..5192378) 1 NC_002695.1 similar to ADIY_ECOLI gi|1790557 (conserved in Escherichia coli K-12); AraC family transcriptional regulator 5192378 914236 ECs5098 Escherichia coli O157:H7 str. Sakai AraC family transcriptional regulator NP_313125.1 5191617 R 386585 CDS NP_313126.1 15834353 914235 complement(5192703..5194973) 1 NC_002695.1 similar to ADIA_ECOLI gi|1790558 (conserved in Escherichia coli K-12); biodegradative arginine decarboxylase 5194973 914235 ECs5099 Escherichia coli O157:H7 str. Sakai biodegradative arginine decarboxylase NP_313126.1 5192703 R 386585 CDS NP_313127.1 15834354 914234 complement(5195169..5196077) 1 NC_002695.1 similar to MELR_ECOLI gi|1790559 (conserved in Escherichia coli K-12); DNA-binding transcriptional regulator MelR 5196077 914234 ECs5100 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional regulator MelR NP_313127.1 5195169 R 386585 CDS NP_313128.1 15834355 914230 5196360..5197715 1 NC_002695.1 similar to MELA_ECOLI gi|1790560 (conserved in Escherichia coli K-12); alpha-galactosidase 5197715 914230 ECs5101 Escherichia coli O157:H7 str. Sakai alpha-galactosidase NP_313128.1 5196360 D 386585 CDS NP_313129.1 15834356 914229 5197830..5199239 1 NC_002695.1 similar to MELB_ECOLI gi|1790561 (conserved in Escherichia coli K-12); melibiose:sodium symporter 5199239 914229 ECs5102 Escherichia coli O157:H7 str. Sakai melibiose:sodium symporter NP_313129.1 5197830 D 386585 CDS NP_313130.1 15834357 914227 complement(5199378..5200007) 1 NC_002695.1 similar to YJDF_ECOLI gi|1790562 (conserved in Escherichia coli K-12); hypothetical protein 5200007 914227 ECs5103 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313130.1 5199378 R 386585 CDS NP_313131.1 15834358 914223 complement(5200130..5201776) 1 NC_002695.1 similar to FUMA_ECOLI gi|1787897 (conserved in Escherichia coli K-12); fumarase B 5201776 914223 ECs5104 Escherichia coli O157:H7 str. Sakai fumarase B NP_313131.1 5200130 R 386585 CDS NP_313132.1 15834359 914219 complement(5201854..5203194) 1 NC_002695.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 5203194 914219 ECs5105 Escherichia coli O157:H7 str. Sakai anaerobic C4-dicarboxylate transporter NP_313132.1 5201854 R 386585 CDS NP_313133.1 15834360 914216 complement(5203765..5204484) 1 NC_002695.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DcuR family transcriptional regulator 5204484 914216 ECs5106 Escherichia coli O157:H7 str. Sakai DcuR family transcriptional regulator NP_313133.1 5203765 R 386585 CDS NP_313134.1 15834361 914212 complement(5204481..5206112) 1 NC_002695.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 5206112 914212 ECs5107 Escherichia coli O157:H7 str. Sakai sensory histidine kinase DcuS NP_313134.1 5204481 R 386585 CDS NP_313135.1 15834362 914209 5206293..5206523 1 NC_002695.1 similar to YJDI_ECOLI gi|1790568 (conserved in Escherichia coli K-12); hypothetical protein 5206523 914209 ECs5108 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313135.1 5206293 D 386585 CDS NP_313136.1 15834363 914201 5206535..5206807 1 NC_002695.1 similar to YJDJ_ECOLI gi|1790569 (conserved in Escherichia coli K-12); hypothetical protein 5206807 914201 ECs5109 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313136.1 5206535 D 386585 CDS NP_313137.1 15834364 914192 5207034..5207330 1 NC_002695.1 similar to YJDK_ECOLI gi|1790570 (conserved in Escherichia coli K-12); hypothetical protein 5207330 914192 ECs5110 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313137.1 5207034 D 386585 CDS NP_313138.1 15834365 914181 complement(5207650..5209167) 1 NC_002695.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 5209167 lysS 914181 lysS Escherichia coli O157:H7 str. Sakai lysyl-tRNA synthetase NP_313138.1 5207650 R 386585 CDS NP_313139.1 15834366 914180 complement(5209404..5210861) 1 NC_002695.1 similar to YJDL_ECOLI gi|1790572 (conserved in Escherichia coli K-12); peptide transporter 5210861 914180 ECs5112 Escherichia coli O157:H7 str. Sakai peptide transporter NP_313139.1 5209404 R 386585 CDS NP_313140.1 15834367 914175 complement(5210920..5213067) 1 NC_002695.1 similar to CADA_ECOLI gi|1790573 (conserved in Escherichia coli K-12); lysine decarboxylase 1 5213067 914175 ECs5113 Escherichia coli O157:H7 str. Sakai lysine decarboxylase 1 NP_313140.1 5210920 R 386585 CDS NP_313141.1 15834368 914165 complement(5213147..5214481) 1 NC_002695.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 5214481 cadB 914165 cadB Escherichia coli O157:H7 str. Sakai lysine/cadaverine antiporter NP_313141.1 5213147 R 386585 CDS NP_313142.1 15834369 914155 complement(5214847..5216385) 1 NC_002695.1 regulates the cadBA operon; CadC family transcriptional regulator 5216385 914155 ECs5115 Escherichia coli O157:H7 str. Sakai CadC family transcriptional regulator NP_313142.1 5214847 R 386585 CDS NP_313143.1 15834370 914146 complement(5217184..5217783) 1 NC_002695.1 similar to YJDC_ECOLI gi|1790577 (conserved in Escherichia coli K-12); transcriptional regulator 5217783 914146 ECs5116 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_313143.1 5217184 R 386585 CDS NP_313144.1 15834371 914141 complement(5217796..5219493) 1 NC_002695.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 5219493 dipZ 914141 dipZ Escherichia coli O157:H7 str. Sakai thiol:disulfide interchange protein NP_313144.1 5217796 R 386585 CDS NP_313145.1 15834372 914138 complement(5219469..5219807) 1 NC_002695.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 5219807 914138 ECs5118 Escherichia coli O157:H7 str. Sakai divalent-cation tolerance protein CutA NP_313145.1 5219469 R 386585 CDS NP_313146.1 15834373 914130 complement(5219923..5221224) 1 NC_002695.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 5221224 914130 ECs5119 Escherichia coli O157:H7 str. Sakai anaerobic C4-dicarboxylate transporter NP_313146.1 5219923 R 386585 CDS NP_313147.2 38704234 914128 complement(5221342..5222778) 1 NC_002695.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 5222778 aspA 914128 aspA Escherichia coli O157:H7 str. Sakai aspartate ammonia-lyase NP_313147.2 5221342 R 386585 CDS NP_313148.1 15834375 914126 5223115..5223591 1 NC_002695.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 5223591 fxsA 914126 fxsA Escherichia coli O157:H7 str. Sakai FxsA protein NP_313148.1 5223115 D 386585 CDS NP_313149.1 15834376 912533 complement(5223607..5224863) 1 NC_002695.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 5224863 912533 ECs5122 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313149.1 5223607 R 386585 CDS NP_313150.1 15834377 913836 5225139..5225432 1 NC_002695.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 5225432 groES 913836 groES Escherichia coli O157:H7 str. Sakai co-chaperonin GroES NP_313150.1 5225139 D 386585 CDS NP_313151.1 15834378 913705 5225476..5227122 1 NC_002695.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 5227122 groEL 913705 groEL Escherichia coli O157:H7 str. Sakai molecular chaperone GroEL NP_313151.1 5225476 D 386585 CDS NP_313152.1 15834379 914086 5227227..5227613 1 NC_002695.1 similar to YJEI_ECOLI gi|1790587 (conserved in Escherichia coli K-12); hypothetical protein 5227613 914086 ECs5125 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313152.1 5227227 D 386585 CDS NP_313153.1 15834380 914122 complement(5227806..5228675) 1 NC_002695.1 similar to YJEJ_ECOLI gi|1790588 (conserved in Escherichia coli K-12); hypothetical protein 5228675 914122 ECs5126 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313153.1 5227806 R 386585 CDS NP_313154.1 15834381 914115 complement(5228910..5229938) 1 NC_002695.1 similar to YJEK_ECOLI gi|1790589 (conserved in Escherichia coli K-12); hypothetical protein 5229938 914115 ECs5127 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313154.1 5228910 R 386585 CDS NP_313155.1 15834382 913175 5229980..5230546 1 NC_002695.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 5230546 913175 ECs5128 Escherichia coli O157:H7 str. Sakai elongation factor P NP_313155.1 5229980 D 386585 CDS NP_944583.1 38704235 2693764 5230834..5230980 1 NC_002695.1 entericidin B membrane lipoprotein 5230980 2693764 ECs5586 Escherichia coli O157:H7 str. Sakai entericidin B membrane lipoprotein NP_944583.1 5230834 D 386585 CDS NP_313156.1 15834383 913177 5231006..5231473 1 NC_002695.1 similar to SUGE_ECOLI gi|1790591 (conserved in Escherichia coli K-12); suppressor of groEL 5231473 913177 ECs5129 Escherichia coli O157:H7 str. Sakai suppressor of groEL NP_313156.1 5231006 D 386585 CDS NP_313157.1 15834384 913180 complement(5231470..5232003) 1 NC_002695.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 5232003 913180 ECs5130 Escherichia coli O157:H7 str. Sakai outer membrane lipoprotein Blc NP_313157.1 5231470 R 386585 CDS NP_313158.1 15834385 914045 complement(5232091..5233224) 1 NC_002695.1 similar to AMPC_ECOLI gi|1790593 (conserved in Escherichia coli K-12); beta-lactamase 5233224 ampC 914045 ampC Escherichia coli O157:H7 str. Sakai beta-lactamase NP_313158.1 5232091 R 386585 CDS NP_313159.1 15834386 913185 complement(5233287..5233646) 1 NC_002695.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 5233646 913185 ECs5132 Escherichia coli O157:H7 str. Sakai fumarate reductase subunit D NP_313159.1 5233287 R 386585 CDS NP_313160.1 15834387 914102 complement(5233657..5234052) 1 NC_002695.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 5234052 914102 ECs5133 Escherichia coli O157:H7 str. Sakai fumarate reductase subunit C NP_313160.1 5233657 R 386585 CDS NP_313161.1 15834388 914097 complement(5234063..5234797) 1 NC_002695.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 5234797 914097 ECs5134 Escherichia coli O157:H7 str. Sakai fumarate reductase iron-sulfur subunit NP_313161.1 5234063 R 386585 CDS NP_313162.1 15834389 915745 complement(5234790..5236598) 1 NC_002695.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 5236598 915745 ECs5135 Escherichia coli O157:H7 str. Sakai fumarate reductase flavoprotein subunit NP_313162.1 5234790 R 386585 CDS NP_313163.2 38704236 915739 5236923..5237900 1 NC_002695.1 lysine--tRNA ligase subunit beta; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 5237900 915739 ECs5136 Escherichia coli O157:H7 str. Sakai lysyl-tRNA synthetase NP_313163.2 5236923 D 386585 CDS NP_313164.1 15834391 915769 5238077..5239621 1 NC_002695.1 similar to YJEM_ECOLI gi|1790600 (conserved in Escherichia coli K-12); transport 5239621 915769 ECs5137 Escherichia coli O157:H7 str. Sakai transport NP_313164.1 5238077 D 386585 CDS NP_313165.1 15834392 915767 complement(5239772..5243095) 1 NC_002695.1 similar to YJEP_ECOLI gi|2367355 (conserved in Escherichia coli K-12); hypothetical protein 5243095 915767 ECs5138 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313165.1 5239772 R 386585 CDS NP_313166.1 15834393 915779 complement(5243117..5244085) 1 NC_002695.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 5244085 psd 915779 psd Escherichia coli O157:H7 str. Sakai phosphatidylserine decarboxylase NP_313166.1 5243117 R 386585 CDS NP_313167.2 38704237 915785 complement(5244182..5245234) 1 NC_002695.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 5245234 915785 ECs5140 Escherichia coli O157:H7 str. Sakai ribosome-associated GTPase NP_313167.2 5244182 R 386585 CDS NP_313168.2 38704238 915776 5245329..5245874 1 NC_002695.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 5245874 915776 ECs5141 Escherichia coli O157:H7 str. Sakai oligoribonuclease NP_313168.2 5245329 D 386585 CDS NP_313169.1 15834396 914085 complement(5246653..5247792) 1 NC_002695.1 similar to YJES_ECOLI gi|1790608 (conserved in Escherichia coli K-12); hypothetical protein 5247792 914085 ECs5143 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313169.1 5246653 R 386585 CDS NP_313170.1 15834397 914083 5247791..5249338 1 NC_002695.1 similar to YJEF_ECOLI gi|1790609 (conserved in Escherichia coli K-12); hypothetical protein 5249338 914083 ECs5142 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313170.1 5247791 D 386585 CDS NP_313171.1 15834398 914082 5249310..5249771 1 NC_002695.1 possibly involved in cell wall synthesis; ATPase 5249771 914082 ECs5144 Escherichia coli O157:H7 str. Sakai ATPase NP_313171.1 5249310 D 386585 CDS NP_313172.1 15834399 914078 5249790..5251127 1 NC_002695.1 similar to AMIB_ECOLI gi|1790611 (conserved in Escherichia coli K-12); N-acetylmuramoyl-l-alanine amidase II 5251127 914078 ECs5145 Escherichia coli O157:H7 str. Sakai N-acetylmuramoyl-l-alanine amidase II NP_313172.1 5249790 D 386585 CDS NP_313173.1 15834400 914075 5251137..5252984 1 NC_002695.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 5252984 mutL 914075 mutL Escherichia coli O157:H7 str. Sakai DNA mismatch repair protein NP_313173.1 5251137 D 386585 CDS NP_313174.1 15834401 914072 5252977..5253927 1 NC_002695.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 5253927 miaA 914072 miaA Escherichia coli O157:H7 str. Sakai tRNA delta(2)-isopentenylpyrophosphate transferase NP_313174.1 5252977 D 386585 CDS NP_313175.1 15834402 914061 5254013..5254321 1 NC_002695.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 5254321 hfq 914061 hfq Escherichia coli O157:H7 str. Sakai RNA-binding protein Hfq NP_313175.1 5254013 D 386585 CDS NP_313176.1 15834403 914058 5254398..5255678 1 NC_002695.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 5255678 914058 ECs5149 Escherichia coli O157:H7 str. Sakai GTPase HflX NP_313176.1 5254398 D 386585 CDS NP_313177.1 15834404 914055 5255764..5257023 1 NC_002695.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 5257023 914055 ECs5150 Escherichia coli O157:H7 str. Sakai FtsH protease regulator HflK NP_313177.1 5255764 D 386585 CDS NP_313178.1 15834405 914054 5257026..5258030 1 NC_002695.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 5258030 914054 ECs5151 Escherichia coli O157:H7 str. Sakai FtsH protease regulator HflC NP_313178.1 5257026 D 386585 CDS NP_313179.1 15834406 914051 5258112..5258309 1 NC_002695.1 similar to YJET_ECOLI gi|1790619 (conserved in Escherichia coli K-12); hypothetical protein 5258309 914051 ECs5152 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313179.1 5258112 D 386585 CDS NP_313180.1 15834407 914042 5258413..5259711 1 NC_002695.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 5259711 914042 ECs5153 Escherichia coli O157:H7 str. Sakai adenylosuccinate synthetase NP_313180.1 5258413 D 386585 CDS NP_313181.1 15834408 914030 5259916..5260341 1 NC_002695.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 5260341 914030 ECs5154 Escherichia coli O157:H7 str. Sakai transcriptional repressor NsrR NP_313181.1 5259916 D 386585 CDS NP_313182.2 38704239 913825 5260380..5262821 1 NC_002695.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 5262821 913825 ECs5155 Escherichia coli O157:H7 str. Sakai exoribonuclease R NP_313182.2 5260380 D 386585 CDS NP_313183.1 15834410 913444 5263002..5263733 1 NC_002695.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 5263733 913444 ECs5156 Escherichia coli O157:H7 str. Sakai 23S rRNA (guanosine-2'-O-)-methyltransferase NP_313183.1 5263002 D 386585 CDS NP_313184.1 15834411 913858 5263860..5264261 1 NC_002695.1 similar to YJFI_ECOLI gi|1790624 (conserved in Escherichia coli K-12); hypothetical protein 5264261 913858 ECs5157 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313184.1 5263860 D 386585 CDS NP_313185.1 15834412 913989 5264280..5264978 1 NC_002695.1 similar to YJFJ_ECOLI gi|1790625 (conserved in Escherichia coli K-12); hypothetical protein 5264978 913989 ECs5158 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313185.1 5264280 D 386585 CDS NP_313186.1 15834413 913851 5265029..5265688 1 NC_002695.1 similar to YJFK_ECOLI gi|1790626 (conserved in Escherichia coli K-12); hypothetical protein 5265688 913851 ECs5159 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313186.1 5265029 D 386585 CDS NP_313187.1 15834414 913304 5265706..5266104 1 NC_002695.1 similar to YJFL_ECOLI gi|1790627 (conserved in Escherichia coli K-12); hypothetical protein 5266104 913304 ECs5160 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313187.1 5265706 D 386585 CDS NP_313188.1 15834415 914025 5266114..5266752 1 NC_002695.1 similar to YJFM_ECOLI gi|1790628 (conserved in Escherichia coli K-12); hypothetical protein 5266752 914025 ECs5161 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313188.1 5266114 D 386585 CDS NP_313189.1 15834416 914024 5266755..5267918 1 NC_002695.1 similar to YJFC_ECOLI gi|1790629 (conserved in Escherichia coli K-12); synthetase/amidase 5267918 914024 ECs5162 Escherichia coli O157:H7 str. Sakai synthetase/amidase NP_313189.1 5266755 D 386585 CDS NP_313190.3 162139725 914022 5267987..5269627 1 NC_002695.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 5269627 914022 ECs5163 Escherichia coli O157:H7 str. Sakai isovaleryl CoA dehydrogenase NP_313190.3 5267987 D 386585 CDS NP_313191.2 38704241 914015 complement(5269744..5270031) 1 NC_002695.1 similar to YJFN_ECOLI gi|1790631 (conserved in Escherichia coli K-12); hypothetical protein 5270031 914015 ECs5164 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313191.2 5269744 R 386585 CDS NP_313192.2 38704242 914014 complement(5270168..5270497) 1 NC_002695.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A 5270497 914014 ECs5165 Escherichia coli O157:H7 str. Sakai biofilm stress and motility protein A NP_313192.2 5270168 R 386585 CDS NP_313193.1 15834420 914013 5270679..5271428 1 NC_002695.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 5271428 914013 ECs5166 Escherichia coli O157:H7 str. Sakai esterase NP_313193.1 5270679 D 386585 CDS NP_313194.1 15834421 914012 complement(5271425..5272180) 1 NC_002695.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 5272180 914012 ECs5167 Escherichia coli O157:H7 str. Sakai transcriptional repressor UlaR NP_313194.1 5271425 R 386585 CDS NP_313195.1 15834422 914011 complement(5272288..5273358) 1 NC_002695.1 similar to YJFR_ECOLI gi|1790636 (conserved in Escherichia coli K-12); L-ascorbate 6-phosphate lactonase 5273358 914011 ECs5168 Escherichia coli O157:H7 str. Sakai L-ascorbate 6-phosphate lactonase NP_313195.1 5272288 R 386585 CDS NP_313196.2 38704243 914004 5273707..5275104 1 NC_002695.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 5275104 ulaA 914004 ulaA Escherichia coli O157:H7 str. Sakai PTS system ascorbate-specific transporter subunit IIC NP_313196.2 5273707 D 386585 CDS NP_313197.1 15834424 914003 5275120..5275425 1 NC_002695.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 5275425 914003 ECs5170 Escherichia coli O157:H7 str. Sakai PTS system L-ascorbate-specific transporter subunit IIB NP_313197.1 5275120 D 386585 CDS NP_313198.1 15834425 914001 5275435..5275899 1 NC_002695.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 5275899 914001 ECs5171 Escherichia coli O157:H7 str. Sakai PTS system L-ascorbate-specific transporter subunit IIA NP_313198.1 5275435 D 386585 CDS NP_313199.1 15834426 913999 5275913..5276563 1 NC_002695.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 5276563 ulaD 913999 ulaD Escherichia coli O157:H7 str. Sakai 3-keto-L-gulonate-6-phosphate decarboxylase NP_313199.1 5275913 D 386585 CDS NP_313200.1 15834427 913998 5276573..5277427 1 NC_002695.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 5277427 913998 ECs5173 Escherichia coli O157:H7 str. Sakai L-xylulose 5-phosphate 3-epimerase NP_313200.1 5276573 D 386585 CDS NP_313201.1 15834428 913993 5277427..5278113 1 NC_002695.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 5278113 sgaE 913993 sgaE Escherichia coli O157:H7 str. Sakai L-ribulose-5-phosphate 4-epimerase NP_313201.1 5277427 D 386585 CDS NP_313202.1 15834429 913992 complement(5278242..5278517) 1 NC_002695.1 similar to YJFY_ECOLI gi|1790643 (conserved in Escherichia coli K-12); hypothetical protein 5278517 913992 ECs5175 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313202.1 5278242 R 386585 CDS NP_313203.1 15834430 913987 5278844..5279239 1 NC_002695.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 5279239 rpsF 913987 rpsF Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S6 NP_313203.1 5278844 D 386585 CDS NP_313204.1 15834431 913985 5279246..5279560 1 NC_002695.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 5279560 913985 ECs5177 Escherichia coli O157:H7 str. Sakai primosomal replication protein N NP_313204.1 5279246 D 386585 CDS NP_313205.1 15834432 913982 5279565..5279792 1 NC_002695.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5279792 rpsR 913982 rpsR Escherichia coli O157:H7 str. Sakai 30S ribosomal protein S18 NP_313205.1 5279565 D 386585 CDS NP_313206.1 15834433 913978 5279834..5280283 1 NC_002695.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 5280283 rplI 913978 rplI Escherichia coli O157:H7 str. Sakai 50S ribosomal protein L9 NP_313206.1 5279834 D 386585 CDS NP_313207.1 15834434 913976 complement(5280354..5281148) 1 NC_002695.1 similar to YJFZ_ECOLI gi|1790648 (conserved in Escherichia coli K-12); hypothetical protein 5281148 913976 ECs5180 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313207.1 5280354 R 386585 CDS NP_313208.1 15834435 913973 5281522..5281917 1 NC_002695.1 similar to YTFA_ECOLI gi|1790650; hypothetical protein 5281917 913973 ECs5181 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313208.1 5281522 D 386585 CDS NP_313209.1 15834436 913967 complement(5281771..5282202) 1 NC_002695.1 TnpA of insertion sequence IS609; similar to transposase homolog A [Helicobacter pylori] gi|2114470|gb|AAD11513.1; transposase 5282202 913967 ECs5182 Escherichia coli O157:H7 str. Sakai transposase NP_313209.1 5281771 R 386585 CDS NP_313210.2 38704244 913966 5282210..5283418 1 NC_002695.1 TnpB of insertion sequence IS609; similar to B1432_ECOLI gi|1787702, transposases Xylella fastidiosa AAF83346; transposase 5283418 913966 ECs5183 Escherichia coli O157:H7 str. Sakai transposase NP_313210.2 5282210 D 386585 CDS NP_313211.1 15834438 913964 complement(5283553..5284227) 1 NC_002695.1 similar to YTFB_ECOLI gi|1790651 (conserved in Escherichia coli K-12); hypothetical protein 5284227 913964 ECs5184 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313211.1 5283553 R 386585 CDS NP_313212.2 38704245 913963 5284409..5285029 1 NC_002695.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 5285029 913963 ECs5185 Escherichia coli O157:H7 str. Sakai peptidyl-prolyl cis-trans isomerase NP_313212.2 5284409 D 386585 CDS NP_313213.1 15834440 913962 5285338..5286750 1 NC_002695.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 5286750 913962 ECs5186 Escherichia coli O157:H7 str. Sakai D-alanine/D-serine/glycine permease NP_313213.1 5285338 D 386585 CDS NP_313214.1 15834441 913956 complement(5286795..5287457) 1 NC_002695.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 5287457 913956 ECs5187 Escherichia coli O157:H7 str. Sakai iron-sulfur cluster repair di-iron protein NP_313214.1 5286795 R 386585 CDS NP_313215.1 15834442 913955 complement(5287565..5288539) 1 NC_002695.1 similar to YTFF_ECOLI gi|1790655 (conserved in Escherichia coli K-12); transmembrane subunit 5288539 913955 ECs5188 Escherichia coli O157:H7 str. Sakai transmembrane subunit NP_313215.1 5287565 R 386585 CDS NP_313216.1 15834443 913947 complement(5288638..5289498) 1 NC_002695.1 similar to YTFG_ECOLI gi|1790656 (conserved in Escherichia coli K-12); oxidoreductase 5289498 913947 ECs5190 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_313216.1 5288638 R 386585 CDS NP_313217.2 38704246 913946 5289587..5289967 1 NC_002695.1 similar to YTFH_ECOLI gi|1790657 (conserved in Escherichia coli K-12); hypothetical protein 5289967 913946 ECs5189 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313217.2 5289587 D 386585 CDS NP_313218.1 15834445 913944 complement(5290085..5292028) 1 NC_002695.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 5292028 cpdB 913944 cpdB Escherichia coli O157:H7 str. Sakai bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein NP_313218.1 5290085 R 386585 CDS NP_313219.1 15834446 913943 5292218..5292958 1 NC_002695.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 5292958 913943 ECs5192 Escherichia coli O157:H7 str. Sakai adenosine-3'(2'),5'-bisphosphate nucleotidase NP_313219.1 5292218 D 386585 CDS NP_313220.1 15834447 913942 5293170..5294108 1 NC_002695.1 similar to YTFI_ECOLI gi|1790661; hypothetical protein 5294108 913942 ECs5193 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313220.1 5293170 D 386585 CDS NP_313221.1 15834448 913940 complement(5294171..5294725) 1 NC_002695.1 similar to YTFJ_ECOLI gi|1790662 (conserved in Escherichia coli K-12); hypothetical protein 5294725 913940 ECs5194 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313221.1 5294171 R 386585 CDS NP_313222.1 15834449 913816 5295011..5295256 1 NC_002695.1 similar to YTFK_ECOLI gi|1790663 (conserved in Escherichia coli K-12); hypothetical protein 5295256 913816 ECs5195 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313222.1 5295011 D 386585 CDS NP_313223.1 15834450 913900 complement(5295352..5296695) 1 NC_002695.1 similar to YTFL_ECOLI gi|1790664 (conserved in Escherichia coli K-12); transporter 5296695 913900 ECs5196 Escherichia coli O157:H7 str. Sakai transporter NP_313223.1 5295352 R 386585 CDS NP_313224.1 15834451 913935 complement(5297018..5297656) 1 NC_002695.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 5297656 913935 ECs5197 Escherichia coli O157:H7 str. Sakai methionine sulfoxide reductase A NP_313224.1 5297018 R 386585 CDS NP_313225.1 15834452 913933 5297862..5299595 1 NC_002695.1 similar to YTFM_ECOLI gi|1790666 (conserved in Escherichia coli K-12); hypothetical protein 5299595 913933 ECs5198 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313225.1 5297862 D 386585 CDS NP_313226.1 15834453 913926 5299592..5303371 1 NC_002695.1 similar to YTFN_ECOLI gi|1790667 (conserved in Escherichia coli K-12); hypothetical protein 5303371 913926 ECs5199 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313226.1 5299592 D 386585 CDS NP_313227.1 15834454 913921 5303374..5303715 1 NC_002695.1 similar to YTFP_ECOLI gi|1790668 (conserved in Escherichia coli K-12); hypothetical protein 5303715 913921 ECs5200 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313227.1 5303374 D 386585 CDS NP_313228.1 15834455 913915 complement(5303456..5303725) 1 NC_002695.1 similar to YJFA_ECOLI gi|1790669 (conserved in Escherichia coli K-12); hypothetical protein 5303725 913915 ECs5201 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313228.1 5303456 R 386585 CDS NP_313229.1 15834456 913912 5303921..5304178 1 NC_002695.1 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 5304178 913912 ECs5202 Escherichia coli O157:H7 str. Sakai antitoxin ChpS NP_313229.1 5303921 D 386585 CDS NP_313230.1 15834457 913901 5304172..5304522 1 NC_002695.1 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 5304522 913901 ECs5203 Escherichia coli O157:H7 str. Sakai toxin ChpB NP_313230.1 5304172 D 386585 CDS NP_313231.1 15834458 913899 complement(5304602..5305132) 1 NC_002695.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 5305132 913899 ECs5204 Escherichia coli O157:H7 str. Sakai inorganic pyrophosphatase NP_313231.1 5304602 R 386585 CDS NP_313232.1 15834459 913898 5305442..5306398 1 NC_002695.1 similar to YTFQ_ECOLI gi|1790674 (conserved in Escherichia coli K-12); LACI-type transcriptional regulator 5306398 913898 ECs5205 Escherichia coli O157:H7 str. Sakai LACI-type transcriptional regulator NP_313232.1 5305442 D 386585 CDS NP_313233.1 15834460 913896 5306538..5308040 1 NC_002695.1 similar to YTFR_ECOLI gi|1790675, YTFS_ECOLI gi|1790676; ABC transporter ATP-binding protein 5308040 913896 ECs5206 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_313233.1 5306538 D 386585 CDS NP_313234.1 15834461 913880 5308051..5309076 1 NC_002695.1 similar to YTFT_ECOLI gi|1790677 (conserved in Escherichia coli K-12); transport system permease 5309076 913880 ECs5207 Escherichia coli O157:H7 str. Sakai transport system permease NP_313234.1 5308051 D 386585 CDS NP_313235.1 15834462 913878 5309087..5310058 1 NC_002695.1 membrane component of a sugar ABC transporter system; ABC transporter permease 5310058 913878 ECs5208 Escherichia coli O157:H7 str. Sakai ABC transporter permease NP_313235.1 5309087 D 386585 CDS NP_313236.1 15834463 913877 complement(5310091..5311089) 1 NC_002695.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 5311089 913877 ECs5209 Escherichia coli O157:H7 str. Sakai fructose-1,6-bisphosphatase NP_313236.1 5310091 R 386585 CDS NP_313237.1 15834464 913873 5311265..5312638 1 NC_002695.1 similar to YJFG_ECOLI gi|1790680 (conserved in Escherichia coli K-12); UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 5312638 913873 ECs5210 Escherichia coli O157:H7 str. Sakai UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase NP_313237.1 5311265 D 386585 CDS NP_313238.1 15834465 913871 complement(5312794..5313345) 1 NC_002695.1 similar to YJGA_ECOLI gi|1790681 (conserved in Escherichia coli K-12); hypothetical protein 5313345 913871 ECs5211 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313238.1 5312794 R 386585 CDS NP_313239.1 15834466 913868 5313439..5314791 1 NC_002695.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 5314791 913868 ECs5212 Escherichia coli O157:H7 str. Sakai peptidase PmbA NP_313239.1 5313439 D 386585 CDS NP_313240.2 38704247 913867 5314975..5315361 1 NC_002695.1 similar to CYBC_ECOLI gi|1790684 (conserved in Escherichia coli K-12); cytochrome b(562) 5315361 913867 ECs5213 Escherichia coli O157:H7 str. Sakai cytochrome b(562) NP_313240.2 5314975 D 386585 CDS NP_313241.1 15834468 913866 complement(5315406..5315870) 1 NC_002695.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 5315870 nrdG 913866 nrdG Escherichia coli O157:H7 str. Sakai anaerobic ribonucleotide reductase-activating protein NP_313241.1 5315406 R 386585 CDS NP_313242.1 15834469 913864 complement(5316060..5318198) 1 NC_002695.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 5318198 913864 ECs5215 Escherichia coli O157:H7 str. Sakai anaerobic ribonucleoside triphosphate reductase NP_313242.1 5316060 R 386585 CDS NP_313243.1 15834470 913860 complement(5318592..5320247) 1 NC_002695.1 similar to TREC_ECOLI gi|1790687 (conserved in Escherichia coli K-12); trehalose-6-phosphate hydrolase 5320247 913860 ECs5216 Escherichia coli O157:H7 str. Sakai trehalose-6-phosphate hydrolase NP_313243.1 5318592 R 386585 CDS NP_313244.1 15834471 913859 complement(5320297..5321718) 1 NC_002695.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC 5321718 913859 ECs5217 Escherichia coli O157:H7 str. Sakai PTS system trehalose(maltose)-specific transporter subunit IIBC NP_313244.1 5320297 R 386585 CDS NP_313245.1 15834472 913856 complement(5321837..5322784) 1 NC_002695.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 5322784 treR 913856 treR Escherichia coli O157:H7 str. Sakai trehalose repressor NP_313245.1 5321837 R 386585 CDS NP_313246.1 15834473 913855 5323163..5325859 1 NC_002695.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 5325859 913855 ECs5219 Escherichia coli O157:H7 str. Sakai magnesium-transporting ATPase MgtA NP_313246.1 5323163 D 386585 CDS NP_313247.1 15834474 913846 complement(5326065..5326490) 1 NC_002695.1 similar to YJGF_ECOLI gi|1790691 (conserved in Escherichia coli K-12); hypothetical protein 5326490 913846 ECs5220 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313247.1 5326065 R 386585 CDS NP_313248.1 15834475 913844 complement(5326524..5326985) 1 NC_002695.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 5326985 913844 ECs5221 Escherichia coli O157:H7 str. Sakai aspartate carbamoyltransferase NP_313248.1 5326524 R 386585 CDS NP_313249.1 15834476 913842 complement(5326998..5327933) 1 NC_002695.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 5327933 pyrB 913842 pyrB Escherichia coli O157:H7 str. Sakai aspartate carbamoyltransferase NP_313249.1 5326998 R 386585 CDS NP_313250.1 15834477 913838 complement(5327937..5328071) 1 NC_002695.1 similar to PYRL_ECOLI gi|1790694 (conserved in Escherichia coli K-12); pyrBI operon leader peptide 5328071 913838 ECs5224 Escherichia coli O157:H7 str. Sakai pyrBI operon leader peptide NP_313250.1 5327937 R 386585 CDS NP_313252.1 15834479 913830 complement(5328352..5328747) 1 NC_002695.1 similar to YJGH_ECOLI gi|1790696 (conserved in Escherichia coli K-12); hypothetical protein 5328747 913830 ECs5225 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313252.1 5328352 R 386585 CDS NP_313253.1 15834480 913828 complement(5328878..5329591) 1 NC_002695.1 similar to YJGI_ECOLI gi|2367365 (conserved in Escherichia coli K-12); oxidoreductase 5329591 913828 ECs5226 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_313253.1 5328878 R 386585 CDS NP_313255.2 38704248 913818 5329662..5330255 1 NC_002695.1 similar to YJGJ_ECOLI gi|1790700 (conserved in Escherichia coli K-12); hypothetical protein 5330255 913818 ECs5228 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313255.2 5329662 D 386585 CDS NP_313256.2 38704249 913815 5330400..5330852 1 NC_002695.1 similar to YJGK_ECOLI gi|1790701 (conserved in Escherichia coli K-12); hypothetical protein 5330852 913815 ECs5229 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313256.2 5330400 D 386585 CDS NP_313257.1 15834484 913810 5330975..5332747 1 NC_002695.1 similar to YJGL_ECOLI gi|1790702; hypothetical protein 5332747 913810 ECs5230 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313257.1 5330975 D 386585 CDS NP_313258.1 15834485 913389 complement(5332804..5333808) 1 NC_002695.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 5333808 913389 ECs5231 Escherichia coli O157:H7 str. Sakai ornithine carbamoyltransferase subunit I NP_313258.1 5332804 R 386585 CDS NP_313259.1 15834486 913392 5333970..5334386 1 NC_002695.1 similar to YJGD_ECOLI gi|1790704 (conserved in Escherichia coli K-12); hypothetical protein 5334386 913392 ECs5232 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313259.1 5333970 D 386585 CDS NP_313260.2 38704250 913397 complement(5334432..5334935) 1 NC_002695.1 similar to B4256_ECOLI gi|1790705 (conserved in Escherichia coli K-12); hypothetical protein 5334935 913397 ECs5233 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313260.2 5334432 R 386585 CDS NP_313261.1 15834488 913808 5335128..5336324 1 NC_002695.1 similar to YJGN_ECOLI gi|2367367 (conserved in Escherichia coli K-12); hypothetical protein 5336324 913808 ECs5234 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313261.1 5335128 D 386585 CDS NP_313262.1 15834489 913806 complement(5336379..5339234) 1 NC_002695.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 5339234 valS 913806 valS Escherichia coli O157:H7 str. Sakai valyl-tRNA synthetase NP_313262.1 5336379 R 386585 CDS NP_313263.1 15834490 913805 complement(5339234..5339677) 1 NC_002695.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 5339677 913805 ECs5236 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit chi NP_313263.1 5339234 R 386585 CDS NP_313264.1 15834491 913804 complement(5340031..5341542) 1 NC_002695.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 5341542 913804 ECs5237 Escherichia coli O157:H7 str. Sakai leucyl aminopeptidase NP_313264.1 5340031 R 386585 CDS NP_313265.1 15834492 913803 5341809..5342909 1 NC_002695.1 similar to YJGP_ECOLI gi|1790712 (conserved in Escherichia coli K-12); hypothetical protein 5342909 913803 ECs5238 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313265.1 5341809 D 386585 CDS NP_313266.2 38704251 913802 5342909..5343991 1 NC_002695.1 similar to YJGQ_ECOLI gi|1790713 (conserved in Escherichia coli K-12); hypothetical protein 5343991 913802 ECs5239 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313266.2 5342909 D 386585 CDS NP_313267.1 15834494 913800 complement(5344152..5345654) 1 NC_002695.1 similar to YJGR_ECOLI gi|1790714 (conserved in Escherichia coli K-12); hypothetical protein 5345654 913800 ECs5240 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313267.1 5344152 R 386585 CDS NP_313268.2 38704252 913797 complement(5345784..5346803) 1 NC_002695.1 similar to YJGB_ECOLI gi|1790720 (conserved in Escherichia coli K-12); oxidoreductase 5346803 913797 ECs5241 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_313268.2 5345784 R 386585 CDS NP_313269.1 15834496 913791 5347174..5349123 1 NC_002695.1 similar to integrases e.g. integrase [Bacteriophage TPW22] gi|6465906|gb|AAF12706.1|AF066865_4; integrase 5349123 913791 ECs5242 Escherichia coli O157:H7 str. Sakai integrase NP_313269.1 5347174 D 386585 CDS NP_313270.1 15834497 913773 5349323..5349649 1 NC_002695.1 OrfA protein of insertion sequence IS629; similar to gi|7444868|pir||T00241; transposase 5349649 913773 ECs5243 Escherichia coli O157:H7 str. Sakai transposase NP_313270.1 5349323 D 386585 CDS NP_313271.1 15834498 913771 5349646..5350536 1 NC_002695.1 OrfB protein of insertion sequence IS629; similar to [Escherichia coli plasmid pO157] gi|7443862|pir||T00240; transposase 5350536 913771 ECs5244 Escherichia coli O157:H7 str. Sakai transposase NP_313271.1 5349646 D 386585 CDS NP_313272.1 15834499 913770 complement(5350719..5351003) 1 NC_002695.1 hypothetical protein 5351003 913770 ECs5245 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313272.1 5350719 R 386585 CDS NP_313273.1 15834500 913768 complement(5351218..5351550) 1 NC_002695.1 hypothetical protein 5351550 913768 ECs5246 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313273.1 5351218 R 386585 CDS NP_313274.1 15834501 913767 complement(5352114..5352290) 1 NC_002695.1 hypothetical protein 5352290 913767 ECs5247 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313274.1 5352114 R 386585 CDS NP_313275.1 15834502 912719 complement(5352554..5353021) 1 NC_002695.1 similar to hypothetical proteins [Staphylococcus aureus] e.g. gi|7594765|dbj|BAA94663.1|, hypothetical proteins [Neisseria meningitidis] gi|5051461|emb|CAB44981.1|; hypothetical protein 5353021 912719 ECs5248 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313275.1 5352554 R 386585 CDS NP_313276.1 15834503 912720 5353208..5353783 1 NC_002695.1 similar to resolvases e.g. resolvase [Escherichia coli transposon Tn2501] gi|135944|sp|P05823|TNP0_ECOLI; resolvase 5353783 912720 ECs5249 Escherichia coli O157:H7 str. Sakai resolvase NP_313276.1 5353208 D 386585 CDS NP_313277.1 15834504 912726 complement(5353982..5355298) 1 NC_002695.1 hypothetical protein 5355298 912726 ECs5250 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313277.1 5353982 R 386585 CDS NP_313278.1 15834505 912567 complement(5355450..5356223) 1 NC_002695.1 hypothetical protein 5356223 912567 ECs5251 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313278.1 5355450 R 386585 CDS NP_313279.1 15834506 913764 5356340..5356804 1 NC_002695.1 similar to transcription regulators e.g. BamH I control element [Bacillus amyloliquefaciens] gi|116073|sp|P23939|CEBA_BACAM; transcriptional regulator 5356804 913764 ECs5252 Escherichia coli O157:H7 str. Sakai transcriptional regulator NP_313279.1 5356340 D 386585 CDS NP_313280.1 15834507 913757 5357520..5358347 1 NC_002695.1 similar to integrases e.g. [prophage P4] gi|732036|sp|P39347|INTB_ECOLI; integrase 5358347 913757 ECs5253 Escherichia coli O157:H7 str. Sakai integrase NP_313280.1 5357520 D 386585 CDS NP_944584.1 38704253 2693750 5358407..5358574 1 NC_002695.1 hypothetical protein 5358574 2693750 ECs5591 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944584.1 5358407 D 386585 CDS NP_313281.1 15834508 913753 complement(5358807..5359658) 1 NC_002695.1 hypothetical protein 5359658 913753 ECs5254 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313281.1 5358807 R 386585 CDS NP_313282.1 15834509 913747 complement(5359645..5359971) 1 NC_002695.1 similar to hypothetical proteins e.g. YjH [Escherichia coli] gi|7404491|sp|P39371|YJHT_ECOLI; hypothetical protein 5359971 913747 ECs5255 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313282.1 5359645 R 386585 CDS NP_313283.1 15834510 913745 complement(5360199..5361302) 1 NC_002695.1 hypothetical protein 5361302 913745 ECs5256 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313283.1 5360199 R 386585 CDS NP_313284.1 15834511 913743 complement(5361306..5362013) 1 NC_002695.1 similar to periplasmic protein [Campylobacter jejuni]gi|6968066|emb|CAB75235.1|; hypothetical protein 5362013 913743 ECs5257 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313284.1 5361306 R 386585 CDS NP_313285.1 15834512 913741 complement(5362020..5363672) 1 NC_002695.1 similar to myosin heavy chains e.g. [Cyprinus carpio] gi|2351223|dbj|BAA22069.1|; hypothetical protein 5363672 913741 ECs5258 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313285.1 5362020 R 386585 CDS NP_313286.1 15834513 913738 5363890..5367243 1 NC_002695.1 similar to YjiT [Escherichia coli] gi|732099|sp|P39391|YJIT_ECOLI; hypothetical protein 5367243 913738 ECs5259 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313286.1 5363890 D 386585 CDS NP_313287.1 15834514 913735 5367243..5373557 1 NC_002695.1 similar to probable RNA helicase Deinococcus radiodurans strain R1 B75633, hypothetical YjiV protein Escherichia coli; hypothetical protein 5373557 913735 ECs5260 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313287.1 5367243 D 386585 CDS NP_313288.1 15834515 913733 5373808..5376639 1 NC_002695.1 similar to ATP-dependent helicases e.g. [Halobacterium sp. (strain NRC-1) plasmid pNRC100] gi|7484100|pir||T08316; ATP-dependent helicase 5376639 913733 ECs5261 Escherichia coli O157:H7 str. Sakai ATP-dependent helicase NP_313288.1 5373808 D 386585 CDS NP_313289.1 15834516 913725 5376642..5381576 1 NC_002695.1 similar to hypothetical proteins e.g. H1130 [Halobacterium sp. (strain NRC-1) plasmid pNRC100] gi|7484076|pir||T08313, restriction /modification enzyme [Campylobacter jejuni] gi|6968147|e; hypothetical protein 5381576 913725 ECs5262 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313289.1 5376642 D 386585 CDS NP_313290.1 15834517 913721 5381576..5387917 1 NC_002695.1 probable RNA helicase, similar to probable RNA helicases e.g. [Deinococcus radiodurans (strain R1)] gi|7473663|pir||B75633; RNA helicase 5387917 913721 ECs5263 Escherichia coli O157:H7 str. Sakai RNA helicase NP_313290.1 5381576 D 386585 CDS NP_313291.1 15834518 913716 5387914..5390028 1 NC_002695.1 similar to DNA helicases e.g. probable DNA helicase H91_ORF529 [Mycoplasma pneumoniae] gi|2495150|sp|P75438|YH91_MYCPN, helicase IV [Escherichia coli] gi|146328|gb|AAA23952.1|; DNA helicase 5390028 913716 ECs5264 Escherichia coli O157:H7 str. Sakai DNA helicase NP_313291.1 5387914 D 386585 CDS NP_313292.1 15834519 913594 complement(5390793..5390975) 1 NC_002695.1 similar to hypothetical protein YchG [Escherichia coli] gi|267475|sp|P30192|YCHG_ECOLI; hypothetical protein 5390975 913594 ECs5265 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313292.1 5390793 R 386585 CDS NP_313293.1 15834520 913668 complement(5390981..5391211) 1 NC_002695.1 similar to hypothetical proteins e.g. YchG [Escherichia coli] gi|267475|sp|P30192|YCHG_ECOLI; hypothetical protein 5391211 913668 ECs5266 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313293.1 5390981 R 386585 CDS NP_313294.1 15834521 913702 complement(5391157..5391399) 1 NC_002695.1 similar to hypothetical protein b1240 [Escherichia coli] gi|7466155|pir||C64871; hypothetical protein 5391399 913702 ECs5267 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313294.1 5391157 R 386585 CDS NP_944585.1 38704254 2693751 5391319..5391504 1 NC_002695.1 hypothetical protein 5391504 2693751 ECs5592 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944585.1 5391319 D 386585 CDS NP_313295.1 15834522 913701 complement(5391522..5392502) 1 NC_002695.1 similar to YJHS_ECOLI gi|1790763 (conserved in Escherichia coli K-12); hypothetical protein 5392502 913701 ECs5268 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313295.1 5391522 R 386585 CDS NP_313296.1 15834523 913698 complement(5392567..5393781) 1 NC_002695.1 similar to YJHT_ECOLI gi|1790764 (conserved in Escherichia coli K-12); N-acetylneuraminic acid mutarotase 5393781 913698 ECs5269 Escherichia coli O157:H7 str. Sakai N-acetylneuraminic acid mutarotase NP_313296.1 5392567 R 386585 CDS NP_313297.2 38704255 913696 complement(5393693..5394409) 1 NC_002695.1 similar to YJHA_ECOLI gi|1790765 (conserved in Escherichia coli K-12); hypothetical protein 5394409 913696 ECs5270 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313297.2 5393693 R 386585 CDS NP_313298.1 15834525 913695 5395865..5396467 1 NC_002695.1 inversion of on/off regulator of fimA; tyrosine recombinase 5396467 913695 ECs5271 Escherichia coli O157:H7 str. Sakai tyrosine recombinase NP_313298.1 5395865 D 386585 CDS NP_313299.1 15834526 913692 5396945..5397541 1 NC_002695.1 inversion of on/off regulator of fimA; tyrosine recombinase 5397541 913692 ECs5272 Escherichia coli O157:H7 str. Sakai tyrosine recombinase NP_313299.1 5396945 D 386585 CDS NP_313300.1 15834527 913688 5398006..5398554 1 NC_002695.1 similar to FIMA_ECOLI gi|1790769 (conserved in Escherichia coli K-12); major type 1 subunit fimbrin; FimA 5398554 913688 ECs5273 Escherichia coli O157:H7 str. Sakai FimA NP_313300.1 5398006 D 386585 CDS NP_313301.1 15834528 913687 5398511..5399158 1 NC_002695.1 fimbrial protein; similar to FIMI_ECOLI gi|1790770 (conserved in Escherichia coli K-12); protein FimI 5399158 913687 ECs5274 Escherichia coli O157:H7 str. Sakai protein FimI NP_313301.1 5398511 D 386585 CDS NP_313302.2 38704256 913685 5399246..5399920 1 NC_002695.1 periplasmic chaperone required for type 1 fimbriae; similar to FIMC_ECOLI gi|1790771 (conserved in Escherichia coli K-12); protein FimC 5399920 913685 ECs5275 Escherichia coli O157:H7 str. Sakai protein FimC NP_313302.2 5399246 D 386585 CDS NP_313303.1 15834530 913683 5399987..5402623 1 NC_002695.1 similar to FIMD_ECOLI gi|1790772 (conserved in Escherichia coli K-12); protein FimD 5402623 913683 ECs5276 Escherichia coli O157:H7 str. Sakai protein FimD NP_313303.1 5399987 D 386585 CDS NP_313304.1 15834531 913682 5402633..5403163 1 NC_002695.1 similar to FIMF_ECOLI gi|1790773 (conserved in Escherichia coli K-12); protein FimF 5403163 913682 ECs5277 Escherichia coli O157:H7 str. Sakai protein FimF NP_313304.1 5402633 D 386585 CDS NP_313305.1 15834532 913678 5403176..5403679 1 NC_002695.1 similar to FIMG_ECOLI gi|1790774 (conserved in Escherichia coli K-12); protein FimG 5403679 913678 ECs5278 Escherichia coli O157:H7 str. Sakai protein FimG NP_313305.1 5403176 D 386585 CDS NP_313306.1 15834533 913676 5403699..5404601 1 NC_002695.1 similar to FIMH_ECOLI gi|1790775 (conserved in Escherichia coli K-12); FimH; minor fimbrial subunit; D-mannose specific adhesin 5404601 913676 ECs5279 Escherichia coli O157:H7 str. Sakai D-mannose specific adhesin NP_313306.1 5403699 D 386585 CDS NP_313307.1 15834534 913673 complement(5404775..5406118) 1 NC_002695.1 similar to GNTP_ECOLI gi|1790776 (conserved in Escherichia coli K-12); fructuronate transporter 5406118 913673 ECs5280 Escherichia coli O157:H7 str. Sakai fructuronate transporter NP_313307.1 5404775 R 386585 CDS NP_313308.1 15834535 913672 5406458..5407642 1 NC_002695.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5407642 913672 ECs5281 Escherichia coli O157:H7 str. Sakai mannonate dehydratase NP_313308.1 5406458 D 386585 CDS NP_313309.1 15834536 913669 5407723..5409183 1 NC_002695.1 similar to UXUB_ECOLI gi|1790779 (conserved in Escherichia coli K-12); D-mannonate oxidoreductase 5409183 913669 ECs5282 Escherichia coli O157:H7 str. Sakai D-mannonate oxidoreductase NP_313309.1 5407723 D 386585 CDS NP_313310.1 15834537 913667 5409398..5410171 1 NC_002695.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5410171 913667 ECs5283 Escherichia coli O157:H7 str. Sakai DNA-binding transcriptional repressor UxuR NP_313310.1 5409398 D 386585 CDS NP_313311.2 38704257 913664 complement(5410312..5411136) 1 NC_002695.1 similar to YJIC_ECOLI gi|1790781 (conserved in Escherichia coli K-12); hypothetical protein 5411136 913664 ECs5284 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313311.2 5410312 R 386585 CDS NP_313312.2 38704258 913663 5411815..5412207 1 NC_002695.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5412207 iraD 913663 iraD Escherichia coli O157:H7 str. Sakai DNA replication/recombination/repair protein NP_313312.2 5411815 D 386585 CDS NP_313313.1 15834540 913661 complement(5413176..5414348) 1 NC_002695.1 similar to IADA_ECOLI gi|1790784 (conserved in Escherichia coli K-12); isoaspartyl dipeptidase 5414348 913661 ECs5286 Escherichia coli O157:H7 str. Sakai isoaspartyl dipeptidase NP_313313.1 5413176 R 386585 CDS NP_313314.1 15834541 913654 complement(5414361..5414822) 1 NC_002695.1 similar to YJIG_ECOLI gi|1790785 (conserved in Escherichia coli K-12); hypothetical protein 5414822 913654 ECs5287 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313314.1 5414361 R 386585 CDS NP_313315.1 15834542 913652 complement(5414819..5415514) 1 NC_002695.1 similar to YJIH_ECOLI gi|1790786 (conserved in Escherichia coli K-12); hypothetical protein 5415514 913652 ECs5288 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313315.1 5414819 R 386585 CDS NP_313316.2 38704259 913651 5415707..5416096 1 NC_002695.1 similar to N-terminal part of YJII_ECOLI gi|1790787; hypothetical protein 5416096 913651 ECs5289 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313316.2 5415707 D 386585 CDS NP_313317.1 15834544 913650 complement(5416459..5421198) 1 NC_002695.1 similar toinvasin [Yersinia pseudotuberculosis] gi|79202|pir||A29646, probable membrane protein b1978 [Escherichia coli K-12] gi|1736642|dbj|BAA15799.1|; invasin 5421198 913650 ECs5290 Escherichia coli O157:H7 str. Sakai invasin NP_313317.1 5416459 R 386585 CDS NP_313318.1 15834545 913649 complement(5421264..5421455) 1 NC_002695.1 hypothetical protein 5421455 913649 ECs5291 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313318.1 5421264 R 386585 CDS NP_313319.1 15834546 913648 complement(5421500..5421700) 1 NC_002695.1 similar to probable membrane protein b1978 [Escherichia coli K-12] gi|1736642|dbj|BAA15799.1|; hypothetical protein 5421700 913648 ECs5292 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313319.1 5421500 R 386585 CDS NP_313320.1 15834547 913647 complement(5421911..5423089) 1 NC_002695.1 similar to YJIJ_ECOLI gi|1790788 (conserved in Escherichia coli K-12); transporter 5423089 913647 ECs5293 Escherichia coli O157:H7 str. Sakai transporter NP_313320.1 5421911 R 386585 CDS NP_313321.1 15834548 913645 complement(5423157..5424146) 1 NC_002695.1 similar to YJIK_ECOLI gi|1790790 (conserved in Escherichia coli K-12); hypothetical protein 5424146 913645 ECs5294 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313321.1 5423157 R 386585 CDS NP_313322.1 15834549 913644 complement(5424265..5426472) 1 NC_002695.1 hypothetical protein 5426472 913644 ECs5295 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313322.1 5424265 R 386585 CDS NP_313323.1 15834550 913634 complement(5426784..5427050) 1 NC_002695.1 hypothetical protein 5427050 913634 ECs5296 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313323.1 5426784 R 386585 CDS NP_313324.1 15834551 913632 complement(5427047..5427814) 1 NC_002695.1 similar to YJIL_ECOLI gi|1790791 (conserved in Escherichia coli K-12); hypothetical protein 5427814 913632 ECs5297 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313324.1 5427047 R 386585 CDS NP_313325.2 38704260 913628 complement(5427824..5428975) 1 NC_002695.1 similar to YJIM_ECOLI gi|1790792 (conserved in Escherichia coli K-12); hypothetical protein 5428975 913628 ECs5298 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313325.2 5427824 R 386585 CDS NP_313326.1 15834553 913627 complement(5429091..5430362) 1 NC_002695.1 similar to YJIN_ECOLI gi|1790793 (conserved in Escherichia coli K-12); hypothetical protein 5430362 913627 ECs5299 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313326.1 5429091 R 386585 CDS NP_313327.1 15834554 913623 complement(5430403..5431635) 1 NC_002695.1 similar to YJIO_ECOLI gi|1790794 (conserved in Escherichia coli K-12); transporter 5431635 913623 ECs5300 Escherichia coli O157:H7 str. Sakai transporter NP_313327.1 5430403 R 386585 CDS NP_313328.1 15834555 913622 5432102..5432884 1 NC_002695.1 similar to YJIP_ECOLI gi|1790795, YJIQ_ECOLI gi|1790796; hypothetical protein 5432884 913622 ECs5301 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313328.1 5432102 D 386585 CDS NP_313329.1 15834556 913616 complement(5433302..5434714) 1 NC_002695.1 similar to YJIR_ECOLI gi|1790797 (conserved in Escherichia coli K-12); regulator 5434714 913616 ECs5302 Escherichia coli O157:H7 str. Sakai regulator NP_313329.1 5433302 R 386585 CDS NP_313330.1 15834557 913613 5434891..5435055 1 NC_002695.1 similar to YJIS_ECOLI gi|1790798 (conserved in Escherichia coli K-12); hypothetical protein 5435055 913613 ECs5303 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313330.1 5434891 D 386585 CDS NP_313331.1 15834558 913612 5435152..5436033 1 NC_002695.1 similar to hypothetical proteins e.g. jhp0462 [Helicobacter pylori (strain J99)] gi|7464730|pir||C71929, jhp0572 [Helicobacter pylori (strain J99)] gi|7464757|pir||H71914; hypothetical protein 5436033 913612 ECs5304 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313331.1 5435152 D 386585 CDS NP_313332.1 15834559 913610 5436081..5437244 1 NC_002695.1 similar to hypothetical protein e.g. jhp0462 [Helicobacter pylori (strain J99)] gi|7464730|pir||C71929, HP0513 [Helicobacter pylori (strain 26695)] gi|7464291|pir||A64584; hypothetical protein 5437244 913610 ECs5305 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313332.1 5436081 D 386585 CDS NP_944586.1 38704261 2693775 complement(5437291..5437632) 1 NC_002695.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 5437632 2693775 ECs5593 Escherichia coli O157:H7 str. Sakai endoribonuclease SymE NP_944586.1 5437291 R 386585 CDS NP_313333.1 15834560 913608 complement(5437853..5439607) 1 NC_002695.1 type I restriction-modification enzyme S subunits e.g. [Citrobacter freundii] pir|S06097|; type I restriction-modification enzyme S subunit 5439607 913608 ECs5306 Escherichia coli O157:H7 str. Sakai type I restriction-modification enzyme S subunit NP_313333.1 5437853 R 386585 CDS NP_313334.1 15834561 913607 complement(5439607..5441088) 1 NC_002695.1 similar to type I restriction modification enzyme M subunits e.g. [EcoA system] gi|421016|pir||A47200; type I restriction modification enzyme M subunit 5441088 913607 ECs5307 Escherichia coli O157:H7 str. Sakai type I restriction modification enzyme M subunit NP_313334.1 5439607 R 386585 CDS NP_313335.1 15834562 913604 complement(5441143..5443575) 1 NC_002695.1 similar to type I restriction-modification enzyme R subunits e.g. [EcoA] gi|2121113|pir||I41291; type I restriction-modification enzyme R subunit 5443575 913604 ECs5308 Escherichia coli O157:H7 str. Sakai type I restriction-modification enzyme R subunit NP_313335.1 5441143 R 386585 CDS NP_313336.1 15834563 913602 5443853..5444137 1 NC_002695.1 similar to hypothetical proteins e.g. [Helicobacter pylori] gi|7464531|pir||E64694; hypothetical protein 5444137 913602 ECs5309 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313336.1 5443853 D 386585 CDS NP_313337.1 15834564 913601 5444146..5445504 1 NC_002695.1 similar to hypothetical protein [Streptomyces coelicolor A3(2)] gi|7479715|pir||T35601; hypothetical protein 5445504 913601 ECs5310 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313337.1 5444146 D 386585 CDS NP_313338.2 38704262 913598 complement(5445573..5446529) 1 NC_002695.1 similar to YJIA_ECOLI gi|1790812 (conserved in Escherichia coli K-12); GTP-binding protein YjiA 5446529 913598 ECs5311 Escherichia coli O157:H7 str. Sakai GTP-binding protein YjiA NP_313338.2 5445573 R 386585 CDS NP_313339.1 15834566 913597 complement(5446540..5446743) 1 NC_002695.1 similar to YJIX_ECOLI gi|1790813 (conserved in Escherichia coli K-12); hypothetical protein 5446743 913597 ECs5312 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313339.1 5446540 R 386585 CDS NP_313340.1 15834567 913596 complement(5446793..5448958) 1 NC_002695.1 similar to YJIY_ECOLI gi|1790814 (conserved in Escherichia coli K-12); carbon starvation protein 5448958 913596 ECs5313 Escherichia coli O157:H7 str. Sakai carbon starvation protein NP_313340.1 5446793 R 386585 CDS NP_313341.1 15834568 913593 complement(5449236..5449778) 1 NC_002695.1 hypothetical protein 5449778 913593 ECs5314 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313341.1 5449236 R 386585 CDS NP_313342.1 15834569 913592 5450007..5451671 1 NC_002695.1 similar to TSR_ECOLI gi|2367378 (conserved in Escherichia coli K-12); methyl-accepting chemotaxis protein I 5451671 913592 ECs5315 Escherichia coli O157:H7 str. Sakai methyl-accepting chemotaxis protein I NP_313342.1 5450007 D 386585 CDS NP_313343.1 15834570 913589 complement(5451720..5453081) 1 NC_002695.1 similar to YJIZ_ECOLI gi|2367379 (conserved in Escherichia coli K-12); transporter 5453081 913589 ECs5316 Escherichia coli O157:H7 str. Sakai transporter NP_313343.1 5451720 R 386585 CDS NP_313344.1 15834571 913586 complement(5453296..5454102) 1 NC_002695.1 similar to YJJM_ECOLI gi|1790818 (conserved in Escherichia coli K-12); hypothetical protein 5454102 913586 ECs5317 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313344.1 5453296 R 386585 CDS NP_313345.1 15834572 913585 5454334..5455371 1 NC_002695.1 similar to YJJN_ECOLI gi|1790819 (conserved in Escherichia coli K-12); oxidoreductase 5455371 913585 ECs5318 Escherichia coli O157:H7 str. Sakai oxidoreductase NP_313345.1 5454334 D 386585 CDS NP_313346.2 162139730 913581 complement(5455508..5457799) 1 NC_002695.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 5457799 913581 ECs5319 Escherichia coli O157:H7 str. Sakai phosphoglycerol transferase I NP_313346.2 5455508 R 386585 CDS NP_313347.1 15834574 915005 complement(5458053..5458550) 1 NC_002695.1 similar to YJJA_ECOLI gi|1790822 (conserved in Escherichia coli K-12); hypothetical protein 5458550 915005 ECs5320 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313347.1 5458053 R 386585 CDS NP_313348.1 15834575 913577 complement(5458596..5459333) 1 NC_002695.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 5459333 913577 ECs5321 Escherichia coli O157:H7 str. Sakai DNA replication protein DnaC NP_313348.1 5458596 R 386585 CDS NP_313349.1 15834576 913487 complement(5459336..5459875) 1 NC_002695.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 5459875 913487 ECs5322 Escherichia coli O157:H7 str. Sakai primosomal protein DnaI NP_313349.1 5459336 R 386585 CDS NP_313350.2 229544777 913526 complement(5459982..5460455) 1 NC_002695.1 similar to YJJB_ECOLI gi|1790825 (conserved in Escherichia coli K-12); hypothetical protein 5460455 913526 ECs5323 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313350.2 5459982 R 386585 CDS NP_313351.2 38704263 913576 complement(5460446..5461270) 1 NC_002695.1 similar to YJJP_ECOLI gi|1790826 (conserved in Escherichia coli K-12); structural protein 5461270 913576 ECs5324 Escherichia coli O157:H7 str. Sakai structural protein NP_313351.2 5460446 R 386585 CDS NP_313352.1 15834579 913573 5461837..5462562 1 NC_002695.1 similar to YJJQ_ECOLI gi|1790827 (conserved in Escherichia coli K-12); regulator 5462562 913573 ECs5325 Escherichia coli O157:H7 str. Sakai regulator NP_313352.1 5461837 D 386585 CDS NP_313353.2 162139729 913571 5462574..5463197 1 NC_002695.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; BglJ family transcriptional regulator 5463197 913571 ECs5326 Escherichia coli O157:H7 str. Sakai BglJ family transcriptional regulator NP_313353.2 5462574 D 386585 CDS NP_313354.1 15834581 913570 complement(5463235..5464023) 1 NC_002695.1 similar to FHUF_ECOLI gi|1790829 (conserved in Escherichia coli K-12); ferric hydroximate transport ferric iron reductase 5464023 913570 ECs5327 Escherichia coli O157:H7 str. Sakai ferric hydroximate transport ferric iron reductase NP_313354.1 5463235 R 386585 CDS NP_313355.2 38704264 913561 5464125..5464400 1 NC_002695.1 similar to YJJZ_ECOLI gi|2495668|sp|P55914 (conserved in Escherichia coli K-12); hypothetical protein 5464400 913561 ECs5328 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313355.2 5464125 D 386585 CDS NP_313356.1 15834583 913556 complement(5464715..5465746) 1 NC_002695.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 5465746 rsmC 913556 rsmC Escherichia coli O157:H7 str. Sakai 16S ribosomal RNA m2G1207 methyltransferase NP_313356.1 5464715 R 386585 CDS NP_313357.1 15834584 913550 5465849..5466262 1 NC_002695.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5466262 913550 ECs5330 Escherichia coli O157:H7 str. Sakai DNA polymerase III subunit psi NP_313357.1 5465849 D 386585 CDS NP_313358.1 15834585 913548 5466231..5466677 1 NC_002695.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5466677 rimI 913548 rimI Escherichia coli O157:H7 str. Sakai ribosomal-protein-alanine N-acetyltransferase NP_313358.1 5466231 D 386585 CDS NP_313359.1 15834586 913547 5466692..5467369 1 NC_002695.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5467369 913547 ECs5332 Escherichia coli O157:H7 str. Sakai nucleotidase NP_313359.1 5466692 D 386585 CDS NP_313360.1 15834587 913543 5467460..5469049 1 NC_002695.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5469049 prfC 913543 prfC Escherichia coli O157:H7 str. Sakai peptide chain release factor 3 NP_313360.1 5467460 D 386585 CDS NP_313361.1 15834588 913532 5469442..5470047 1 NC_002695.1 similar to OSMY_ECOLI gi|1790836 (conserved in Escherichia coli K-12); hypothetical protein 5470047 913532 ECs5334 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313361.1 5469442 D 386585 CDS NP_313362.1 15834589 913522 5470457..5471530 1 NC_002695.1 similar to YJJU_ECOLI gi|1790837 (conserved in Escherichia coli K-12); hypothetical protein 5471530 913522 ECs5335 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313362.1 5470457 D 386585 CDS NP_313363.1 15834590 913519 5471671..5472309 1 NC_002695.1 similar to YJJV_ECOLI gi|1790838; hypothetical protein 5472309 913519 ECs5336 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313363.1 5471671 D 386585 CDS NP_313364.1 15834591 913512 complement(5472523..5473386) 1 NC_002695.1 similar to YJJW_ECOLI gi|1790839 (conserved in Escherichia coli K-12); activating enzyme 5473386 913512 ECs5337 Escherichia coli O157:H7 str. Sakai activating enzyme NP_313364.1 5472523 R 386585 CDS NP_313367.1 15834594 913508 5475165..5475944 1 NC_002695.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5475944 913508 ECs5340 Escherichia coli O157:H7 str. Sakai deoxyribose-phosphate aldolase NP_313367.1 5475165 D 386585 CDS NP_944587.1 38704265 2693797 5476071..5476202 1 NC_002695.1 hypothetical protein 5476202 2693797 ECs5595 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_944587.1 5476071 D 386585 CDS NP_313368.1 15834595 913506 5476199..5477392 1 NC_002695.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5477392 deoA 913506 deoA Escherichia coli O157:H7 str. Sakai thymidine phosphorylase NP_313368.1 5476199 D 386585 CDS NP_313369.1 15834596 913501 5477444..5478667 1 NC_002695.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5478667 913501 ECs5342 Escherichia coli O157:H7 str. Sakai phosphopentomutase NP_313369.1 5477444 D 386585 CDS NP_313370.1 15834597 913500 5478724..5479443 1 NC_002695.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5479443 deoD 913500 deoD Escherichia coli O157:H7 str. Sakai purine nucleoside phosphorylase NP_313370.1 5478724 D 386585 CDS NP_313371.1 15834598 913499 complement(5479604..5479867) 1 NC_002695.1 hypothetical protein 5479867 913499 ECs5344 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313371.1 5479604 R 386585 CDS NP_313372.1 15834599 913498 complement(5479899..5481587) 1 NC_002695.1 in E. coli the lipoate ligase A catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes; creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; unknown domain/lipoate-protein ligase A fusion protein 5481587 913498 ECs5345 Escherichia coli O157:H7 str. Sakai unknown domain/lipoate-protein ligase A fusion protein NP_313372.1 5479899 R 386585 CDS NP_313373.1 15834600 913496 5481693..5482661 1 NC_002695.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5482661 serB 913496 serB Escherichia coli O157:H7 str. Sakai phosphoserine phosphatase NP_313373.1 5481693 D 386585 CDS NP_313374.1 15834601 913495 5482710..5484092 1 NC_002695.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5484092 913495 ECs5347 Escherichia coli O157:H7 str. Sakai DNA repair protein RadA NP_313374.1 5482710 D 386585 CDS NP_313375.2 162139728 913494 5484113..5485345 1 NC_002695.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5485345 913494 ECs5348 Escherichia coli O157:H7 str. Sakai nicotinamide-nucleotide adenylyltransferase NP_313375.2 5484113 D 386585 CDS NP_313376.1 15834603 913493 complement(5485653..5487320) 1 NC_002695.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 5487320 913493 ECs5349 Escherichia coli O157:H7 str. Sakai ABC transporter ATP-binding protein NP_313376.1 5485653 R 386585 CDS NP_313377.2 162139727 913492 5487531..5489468 1 NC_002695.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5489468 913492 ECs5350 Escherichia coli O157:H7 str. Sakai lytic murein transglycosylase NP_313377.2 5487531 D 386585 CDS NP_313378.1 15834605 913491 5489558..5489884 1 NC_002695.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5489884 913491 ECs5351 Escherichia coli O157:H7 str. Sakai Trp operon repressor NP_313378.1 5489558 D 386585 CDS NP_313379.2 162139726 913489 complement(5490031..5490543) 1 NC_002695.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 5490543 913489 ECs5352 Escherichia coli O157:H7 str. Sakai NTPase NP_313379.2 5490031 R 386585 CDS NP_313380.1 15834607 913488 5490595..5491242 1 NC_002695.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5491242 913488 ECs5353 Escherichia coli O157:H7 str. Sakai phosphoglycerate mutase NP_313380.1 5490595 D 386585 CDS NP_313381.1 15834608 913486 complement(5491239..5492108) 1 NC_002695.1 similar to ROB_ECOLI gi|1790857 (conserved in Escherichia coli K-12); right origin-binding protein 5492108 913486 ECs5354 Escherichia coli O157:H7 str. Sakai right origin-binding protein NP_313381.1 5491239 R 386585 CDS NP_313382.1 15834609 913485 5492319..5492792 1 NC_002695.1 similar to CREA_ECOLI gi|1790859 (conserved in Escherichia coli K-12); hypothetical protein 5492792 913485 ECs5355 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313382.1 5492319 D 386585 CDS NP_313383.1 15834610 913483 5492805..5493494 1 NC_002695.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5493494 913483 ECs5356 Escherichia coli O157:H7 str. Sakai DNA-binding response regulator CreB NP_313383.1 5492805 D 386585 CDS NP_313384.1 15834611 913481 5493494..5494918 1 NC_002695.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5494918 913481 ECs5357 Escherichia coli O157:H7 str. Sakai sensory histidine kinase CreC NP_313384.1 5493494 D 386585 CDS NP_313385.1 15834612 913480 5494976..5496328 1 NC_002695.1 similar to CRED_ECOLI gi|1790862 (conserved in Escherichia coli K-12); hypothetical protein 5496328 913480 ECs5358 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313385.1 5494976 D 386585 CDS NP_313386.1 15834613 913476 complement(5496388..5497104) 1 NC_002695.1 similar to ARCA_ECOLI gi|1790863 (conserved in Escherichia coli K-12); two-component response regulator 5497104 913476 ECs5359 Escherichia coli O157:H7 str. Sakai two-component response regulator NP_313386.1 5496388 R 386585 CDS NP_313387.1 15834614 913475 5497200..5497340 1 NC_002695.1 similar to YJJY_ECOLI gi|1790864 (conserved in Escherichia coli K-12); hypothetical protein 5497340 913475 ECs5360 Escherichia coli O157:H7 str. Sakai hypothetical protein NP_313387.1 5497200 D 386585 CDS NP_313388.1 15834615 913472 5497740..5498426 1 NC_002695.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 5498426 913472 ECs5361 Escherichia coli O157:H7 str. Sakai RNA methyltransferase NP_313388.1 5497740 D 386585 CDS